Recent activities of the Seismology Division Early Career Representative(s)

NASA Astrophysics Data System (ADS)

Agius, Matthew; Van Noten, Koen; Ermert, Laura; Mai, P. Martin; Krawczyk, CharLotte

2016-04-01

The European Geosciences Union is a bottom-up-organisation, in which its members are represented by their respective scientific divisions, committees and council. In recent years, EGU has embarked on a mission to reach out for its numerous 'younger' members by giving awards to outstanding young scientists and the setting up of Early Career Scientists (ECS) representatives. The division representative's role is to engage in discussions that concern students and early career scientists. Several meetings between all the division representatives are held throughout the year to discuss ideas and Union-wide issues. One important impact ECS representatives have had on EGU is the increased number of short courses and workshops run by ECS during the annual General Assembly. Another important contribution of ECS representatives was redefining 'Young Scientist' to 'Early Career Scientist', which avoids discrimination due to age. Since 2014, the Seismology Division has its own ECS representative. In an effort to more effectively reach out for young seismologists, a blog and a social media page dedicated to seismology have been set up online. With this dedicated blog, we'd like to give more depth to the average browsing experience by enabling young researchers to explore various seismology topics in one place while making the field more exciting and accessible to the broader community. These pages are used to promote the latest research especially of young seismologists and to share interesting seismo-news. Over the months the pages proved to be popular, with hundreds of views every week and an increased number of followers. An online survey was conducted to learn more about the activities and needs of early career seismologists. We present the results from this survey, and the work that has been carried out over the last two years, including detail of what has been achieved so far, and what we would like the ECS representation for Seismology to achieve. Young seismologists are continuously encouraged to voice their ideas and contribute to the Seismology Division.

Aerospace Human Factors

NASA Technical Reports Server (NTRS)

Jordan, Kevin

1999-01-01

The following contains the final report on the activities related to the Cooperative Agreement between the human factors research group at NASA Ames Research Center and the Psychology Department at San Jose State University. The participating NASA Ames division has been, as the organization has changed, the Aerospace Human Factors Research Division (ASHFRD and Code FL), the Flight Management and Human Factors Research Division (Code AF), and the Human Factors Research and Technology Division (Code IH). The inclusive dates for the report are November 1, 1984 to January 31, 1999. Throughout the years, approximately 170 persons worked on the cooperative agreements in one capacity or another. The Cooperative Agreement provided for research personnel to collaborate with senior scientists in ongoing NASA ARC research. Finally, many post-MA/MS and post-doctoral personnel contributed to the projects. It is worth noting that 10 former cooperative agreement personnel were hired into civil service positions directly from the agreements.

Honors

NASA Astrophysics Data System (ADS)

Anonymous

2013-07-01

The Geological Society of America's (GSA) new class of medal and award recipients and fellows includes many AGU members. Medal and award recipients are Stephen G. Pollock, University of Southern Maine: GSA Distinguished Service Award; John R. Wheaton, Montana Bureau of Mines and Geology: John C. Frye Award; Clifford A. Jacobs, National Science Foundation (NSF): Outstanding Contributions Award, Geoinformatics Division; Peter Bird, University of California, Los Angeles (emeritus): George P. Woollard Award, Geophysics Division; Chunmiao Zheng, University of Alabama: O. E. Meinzer Award, Hydrogeology Division; Gerhard Wörner, Georg August Universität Göttingen: Distinguished Geologic Career Award, Mineralogy, Geochemistry, Petrology, and Volcanology Division; Alan D. Howard, University of Virginia: G. K. Gilbert Award, Planetary Geology Division; Michael E. Perkins, University of Utah: Kirk Bryan Award for Research Excellence, Quaternary Geology and Geomorphology Division; and Peter J. Hudleston, University of Minnesota: Career Contribution Award, Structural Geology and Tectonics Division.

Reading and Writing Journals: Balancing Skills and Humanities in the English Classroom.

ERIC Educational Resources Information Center

Pezzulich, Evelyn

Interdepartmental rivalries between literature instruction and composition instruction have contributed to viewing reading and writing as disconnected activities. One solution to this divisiveness is a course in "the journal as a literary tradition," which combines reading and writing in equal portions. Students first learn about the…

Cell growth, division, and death in cohesive tissues: A thermodynamic approach

NASA Astrophysics Data System (ADS)

Yabunaka, Shunsuke; Marcq, Philippe

2017-08-01

Cell growth, division, and death are defining features of biological tissues that contribute to morphogenesis. In hydrodynamic descriptions of cohesive tissues, their occurrence implies a nonzero rate of variation of cell density. We show how linear nonequilibrium thermodynamics allows us to express this rate as a combination of relevant thermodynamic forces: chemical potential, velocity divergence, and activity. We illustrate the resulting effects of the nonconservation of cell density on simple examples inspired by recent experiments on cell monolayers, considering first the velocity of a spreading front, and second an instability leading to mechanical waves.

YneA, an SOS-Induced Inhibitor of Cell Division in Bacillus subtilis, Is Regulated Posttranslationally and Requires the Transmembrane Region for Activity▿ †

PubMed Central

Mo, Allison H.; Burkholder, William F.

2010-01-01

Cell viability depends on the stable transmission of genetic information to each successive generation. Therefore, in the event of intrinsic or extrinsic DNA damage, it is important that cell division be delayed until DNA repair has been completed. In Bacillus subtilis, this is accomplished in part by YneA, an inhibitor of division that is induced as part of the SOS response. We sought to gain insight into the mechanism by which YneA blocks cell division and the processes involved in shutting off YneA activity. Our data suggest that YneA is able to inhibit daughter cell separation as well as septum formation. YneA contains a LysM peptidoglycan binding domain and is predicted to be exported. We established that the YneA signal peptide is rapidly cleaved, resulting in secretion of YneA into the medium. Mutations within YneA affect both the rate of signal sequence cleavage and the activity of YneA. YneA does not stably associate with the cell wall and is rapidly degraded by extracellular proteases. Based on these results, we hypothesize that exported YneA is active prior to signal peptide cleavage and that proteolysis contributes to the inactivation of YneA. Finally, we identified mutations in the transmembrane segment of YneA that abolish the ability of YneA to inhibit cell division, while having little or no effect on YneA export or stability. These data suggest that protein-protein interactions mediated by the transmembrane region may be required for YneA activity. PMID:20400548

Division of Adolescent and School Health School Health Programs, 2008. At a Glance

ERIC Educational Resources Information Center

Centers for Disease Control and Prevention, 2008

2008-01-01

Six priority health risk behaviors contribute to the leading causes of death, disability, and social problems in the United States. These behaviors are often established during childhood and adolescence. They include tobacco use; unhealthy dietary behaviors; inadequate physical activity; alcohol and other drug use; sexual behaviors that may result…

Selected Aquatic Articles. Sports Articles Reprint Series. Second Edition.

ERIC Educational Resources Information Center

Clement, Annie, Ed.

This is a collection of articles from the "DGWS (Division for Girls and Women's Sports) Aquatic Guides" from 1963-1969. All articles, with one exception, were revised to present the most important contributions for that time period in aquatic activity beyond simple swimming. Included in the selection are articles on fear and the…

NMR Studies of Structure-Reactivity Relationships in Carbonyl Reduction: A Collaborative Advanced Laboratory Experiment

ERIC Educational Resources Information Center

Marincean, Simona; Smith, Sheila R.; Fritz, Michael; Lee, Byung Joo; Rizk, Zeinab

2012-01-01

An upper-division laboratory project has been developed as a collaborative investigation of a reaction routinely taught in organic chemistry courses: the reduction of carbonyl compounds by borohydride reagents. Determination of several trends regarding structure-activity relationship was possible because each student contributed his or her results…

Water for the Nation: An overview of the USGS Water Resources Division

USGS Publications Warehouse

,

1998-01-01

The Water Resources Division (WRD) of the U.S. Geological Survey (USGS) provides reliable, impartial, timely information needed to understand the Nation's water resources. WRD actively promotes the use of this information by decisionmakers to: * Minimize the loss of life and property as a result of water-related hazards such as floods, droughts, and land movement. * Effectively manage ground-water and surface-water resources for domestic, agricultural, commercial, industrial, recreational, and ecological uses. * Protect and enhance water resources for human health, aquatic health, and environmental quality. * Contribute to wise physical and economic development of the Nation's resources for the benefit of present and future generations.

Coordination of peptidoglycan synthesis and outer membrane constriction during Escherichia coli cell division

PubMed Central

Gray, Andrew N; Egan, Alexander JF; van't Veer, Inge L; Verheul, Jolanda; Colavin, Alexandre; Koumoutsi, Alexandra; Biboy, Jacob; Altelaar, A F Maarten; Damen, Mirjam J; Huang, Kerwyn Casey; Simorre, Jean-Pierre; Breukink, Eefjan; den Blaauwen, Tanneke; Typas, Athanasios; Gross, Carol A; Vollmer, Waldemar

2015-01-01

To maintain cellular structure and integrity during division, Gram-negative bacteria must carefully coordinate constriction of a tripartite cell envelope of inner membrane, peptidoglycan (PG), and outer membrane (OM). It has remained enigmatic how this is accomplished. Here, we show that envelope machines facilitating septal PG synthesis (PBP1B-LpoB complex) and OM constriction (Tol system) are physically and functionally coordinated via YbgF, renamed CpoB (Coordinator of PG synthesis and OM constriction, associated with PBP1B). CpoB localizes to the septum concurrent with PBP1B-LpoB and Tol at the onset of constriction, interacts with both complexes, and regulates PBP1B activity in response to Tol energy state. This coordination links PG synthesis with OM invagination and imparts a unique mode of bifunctional PG synthase regulation by selectively modulating PBP1B cross-linking activity. Coordination of the PBP1B and Tol machines by CpoB contributes to effective PBP1B function in vivo and maintenance of cell envelope integrity during division. DOI: http://dx.doi.org/10.7554/eLife.07118.001 PMID:25951518

Therapeutic approach to Class II, Division 1 malocclusion with maxillary functional orthopedics

PubMed Central

de Bittencourt, Aristeu Corrêa; Saga, Armando Yukio; Pacheco, Ariel Adriano Reyes; Tanaka, Orlando

2015-01-01

INTRODUCTION: Interceptive treatment of Class II, Division 1 malocclusion is a challenge orthodontists commonly face due to the different growth patterns they come across and the different treatment strategies they have available. OBJECTIVE: To report five cases of interceptive orthodontics performed with the aid of Klammt's elastic open activator (KEOA) to treat Class II, Division 1 malocclusion. METHODS: Treatment comprehends one or two phases; and the use of functional orthopedic appliances, whenever properly recommended, is able to minimize dentoskeletal discrepancies with consequent improvement in facial esthetics during the first stage of mixed dentition. The triad of diagnosis, correct appliance manufacture and patient's compliance is imperative to allow KEOA to contribute to Class II malocclusion treatment. RESULTS: Cases reported herein showed significant improvement in skeletal, dental and profile aspects, as evinced by cephalometric analysis and clinical photographs taken before, during and after interceptive orthodontics. PMID:26352852

New insights from a high-resolution look at gastrulation in the sea urchin, Lytechinus variegatus.

PubMed

Martik, Megan L; McClay, David R

2017-12-01

Gastrulation is a complex orchestration of movements by cells that are specified early in development. Until now, classical convergent extension was considered to be the main contributor to sea urchin archenteron extension, and the relative contributions of cell divisions were unknown. Active migration of cells along the axis of extension was also not considered as a major factor in invagination. Cell transplantations plus live imaging were used to examine endoderm cell morphogenesis during gastrulation at high-resolution in the optically clear sea urchin embryo. The invagination sequence was imaged throughout gastrulation. One of the eight macromeres was replaced by a fluorescently labeled macromere at the 32 cell stage. At gastrulation those patches of fluorescent endoderm cell progeny initially about 4 cells wide, released a column of cells about 2 cells wide early in gastrulation and then often this column narrowed to one cell wide by the end of archenteron lengthening. The primary movement of the column of cells was in the direction of elongation of the archenteron with the narrowing (convergence) occurring as one of the two cells moved ahead of its neighbor. As the column narrowed, the labeled endoderm cells generally remained as a contiguous population of cells, rarely separated by intrusion of a lateral unlabeled cell. This longitudinal cell migration mechanism was assessed quantitatively and accounted for almost 90% of the elongation process. Much of the extension was the contribution of Veg2 endoderm with a minor contribution late in gastrulation by Veg1 endoderm cells. We also analyzed the contribution of cell divisions to elongation. Endoderm cells in Lytechinus variagatus were determined to go through approximately one cell doubling during gastrulation. That doubling occurs without a net increase in cell mass, but the question remained as to whether oriented divisions might contribute to archenteron elongation. We learned that indeed there was a biased orientation of cell divisions along the plane of archenteron elongation, but when the impact of that bias was analyzed quantitatively, it contributed a maximum 15% to the total elongation of the gut. The major driver of archenteron elongation in the sea urchin, Lytechinus variagatus, is directed movement of Veg2 endoderm cells as a narrowing column along the plane of elongation. The narrowing occurs as cells in the column converge as they migrate, so that the combination of migration and the angular convergence provide the major component of the lengthening. A minor contributor to elongation is oriented cell divisions that contribute to the lengthening but no more than about 15%. Copyright © 2017 Elsevier B.V. All rights reserved.

Evolutionary dynamics of division of labor games with selfish agents

NASA Astrophysics Data System (ADS)

Zhang, Jianlei; Li, Qiaoyu; Zhang, Chunyan

2017-11-01

The division of labor is one of the most basic and widely studied aspects of collective behavior in natural systems. Studies of division of labor are concerned with the integration of the individual worker behavior into a colony level task organization and with the question of how the regulation of the division of labor may contribute to the colony efficiency. This paper investigates the evolution of the division of labor with three strategies by employing the evolutionary game theory. Thus, these available strategies are, respectively, strategy A (performing task A), strategy B (performing task B), and strategy D (not performing any task but only free riding others' contributions). And, two typical networks (i.e., BA scale-free network and lattice network) are employed here for describing the interaction structure among agents. The theoretical analysis together with simulation results reveal that the division of labor can evolve and leads to players that differ in their tendency to take on a given task. The conditions under which the division of labor evolves depend on the costs for performing the task, the benefits led by performing the task, and the interaction structures among the players who are involved with division of labor games.

Biology Division progress report, October 1, 1993--September 30, 1995

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1995-10-01

This Progress Report summarizes the research endeavors of the Biology Division of the Oak Ridge National Laboratory during the period October 1, 1993, through September 30, 1995. The report is structured to provide descriptions of current activities and accomplishments in each of the Division`s major organizational units. Lists of information to convey the entire scope of the Division`s activities are compiled at the end of the report. Attention is focused on the following research activities: molecular, cellular, and cancer biology; mammalian genetics and development; genome mapping program; and educational activities.

Exposure of Human CD8+ T Cells to Type-2 Cytokines Impairs Division and Differentiation and Induces Limited Polarization.

PubMed

Fox, Annette; Harland, Kim L; Kedzierska, Katherine; Kelso, Anne

2018-01-01

Effector CD8 + T cells generally produce type-1 cytokines and mediators of the perforin/granzyme cytolytic pathway, yet type-2-polarized CD8 + cells (Tc2) are detected in type-2 (T2) cytokine-driven diseases such as asthma. It is unclear whether T2 cytokine exposure during activation is sufficient to polarize human CD8 + T cells. To address this question, a protocol was developed for high-efficiency activation of human CD8 + T cells in which purified single cells or populations were stimulated with plate-bound anti-CD3 and anti-CD11a mAb for up to 8 days in T2 polarizing or neutral conditions, before functional analysis. Activation of CD8 + naïve T cells (T N ) in T2 compared with neutral conditions decreased the size of single-cell clones, although early division kinetics were equivalent, indicating an effect on overall division number. Activation of T N in T2 conditions followed by brief anti-CD3 mAb restimulation favored expression of T2 cytokines, GATA3 and Eomes , and lowered expression of type-1 cytokines, Prf1 , Gzmb, T-BET, and Prdm1 . However, IL-4 was only weakly expressed, and PMA and ionomycin restimulation favored IFN-γ over IL-4 expression. Activation of T N in T2 compared with neutral conditions prevented downregulation of costimulatory (CD27, CD28) and lymph-node homing receptors (CCR7) and CD95 acquisition, which typically occur during differentiation into effector phenotypes. CD3 was rapidly and substantially induced after activation in neutral, but not T2 conditions, potentially contributing to greater division and differentiation in neutral conditions. CD8 + central memory T cells (T CM ) were less able to enter division upon reactivation in T2 compared with neutral conditions, and were more refractory to modulating IFN-γ and IL-4 production than CD8 + T N. In summary, while activation of T N in T2 conditions can generate T2 cytokine-biased cells, IL-4 expression is weak, T2 bias is lost upon strong restimulation, differentiation, and division are arrested, and reactivation of T CM is reduced in T2 conditions. Taken together, this suggests that exposure to T2 cytokines during activation may not be sufficient to generate and retain human Tc2 cells.

A Survey of Approaches Used in Teaching Reading in Early Childhood Classes in Dagoretti and Westlands Divisions, Nairobi County, Kenya

ERIC Educational Resources Information Center

Marima, Esther Wairimu

2016-01-01

Reading proficiency has been identified as one of the most reliable indicators of whether a learner will attain the competence needed to achieve academic success and contribute actively to society. Research findings in Kenyan primary and secondary schools reveal inadequate reading skills among the students. There are different approaches in…

Has the Educational System in Lebanon Contributed to the Growing Sectarian Divisions?

ERIC Educational Resources Information Center

Baytiyeh, Hoda

2017-01-01

The sectarian structure of the Lebanese political system has contributed to periods of sectarian violence and wars over the past four decades. This article highlights the origin of sectarianism in Lebanon and discusses how public and religious schools in the country have reinforced sectarian divisions in the Lebanese society. This is a conceptual…

Coordinating cell proliferation and differentiation: Antagonism between cell cycle regulators and cell type-specific gene expression

PubMed Central

Ruijtenberg, Suzan; van den Heuvel, Sander

2016-01-01

ABSTRACT Cell proliferation and differentiation show a remarkable inverse relationship. Precursor cells continue division before acquiring a fully differentiated state, while terminal differentiation usually coincides with proliferation arrest and permanent exit from the division cycle. Mechanistic insight in the temporal coordination between cell cycle exit and differentiation has come from studies of cells in culture and genetic animal models. As initially described for skeletal muscle differentiation, temporal coordination involves mutual antagonism between cyclin-dependent kinases that promote cell cycle entry and transcription factors that induce tissue-specific gene expression. Recent insights highlight the contribution of chromatin-regulating complexes that act in conjunction with the transcription factors and determine their activity. In particular SWI/SNF chromatin remodelers contribute to dual regulation of cell cycle and tissue-specific gene expression during terminal differentiation. We review the concerted regulation of the cell cycle and cell type-specific transcription, and discuss common mutations in human cancer that emphasize the clinical importance of proliferation versus differentiation control. PMID:26825227

Academic Persistence of International Student-Athletes at NCAA Division I Institutions

ERIC Educational Resources Information Center

Kitsos, Jayne M.

2012-01-01

This study examined academic support programs and personnel that contributed to international student-athlete academic persistence at the National Collegiate Athletics Association (NCAA) Division I level. The purpose of the study was to identify athletic academic personnel's explanations for the academic persistence of NCAA Division I…

Physics and Advanced Technologies 2003 Annual Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hazi, A; Sketchley, J

2005-01-20

The Physics and Advanced Technologies (PAT) Directorate overcame significant challenges in 2003 to deliver a wealth of scientific and programmatic milestones, and move toward closer alignment with programs at Lawrence Livermore National Laboratory. We acted aggressively in enabling the PAT Directorate to contribute to future, growing Lawrence Livermore missions in homeland security and at the National Ignition Facility (NIF). We made heavy investments to bring new capabilities to the Laboratory, to initiate collaborations with major Laboratory programs, and to align with future Laboratory directions. Consistent with our mission, we sought to ensure that Livermore programs have access to the bestmore » science and technology, today and tomorrow. For example, in a move aimed at revitalizing the Laboratory's expertise in nuclear and radiation detection, we brought the talented Measurement Sciences Group to Livermore from Lawrence Berkeley National Laboratory, after its mission there had diminished. The transfer to our I Division entailed significant investment by PAT in equipment and infrastructure required by the group. In addition, the move occurred at a time when homeland security funding was expected, but not yet available. By the end of the year, though, the group was making crucial contributions to the radiation detection program at Livermore, and nearly every member was fully engaged in programmatic activities. Our V Division made a move of a different sort, relocating en masse from Building 121 to the NIF complex. This move was designed to enhance interaction and collaboration among high-energy-density experimental scientists at the Laboratory, a goal that is essential to the effective use of NIF in the future. Since then, V Division has become increasingly integrated with NIF activities. Division scientists are heavily involved in diagnostic development and fielding and are poised to perform equation-of-state and high-temperature hohlraum experiments in 2004 as part of the NIF Early Light program.« less

American Chemical Society division of fuel chemistry Henry H. Storch award.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chemistry

American Chemical Society Division of Fuel Chemistry Henry H. Storch Award ... The purpose of the Henry H. Storch Award is to recognize distinguished contributions worldwide to fundamental or engineering research on the chemistry and utilization of all hydrocarbon fuels, with the exception of petroleum. ... The award was established in 1964 by the American Chemical Society Division of Fuel Chemistry and administered by the Division until 1985.

Overview of Workplace Issues in the 2002 Status of the Armed Forces Survey

DTIC Science & Technology

2003-11-01

Metropolitan Area (American University and George Mason University) Defense Manpower Data Center Survey & Program Evaluation Division 1600 Wilson...Research Fellows Program contributed to the production of this report. A team including Elizabeth Willis, Rachel Lipari, and Eric Wetzel from DMDC, and...members took more active steps related to leaving the military, including: preparing a resume (23%), attending programs that prepare for civilian

Factors Related to Annual Fund-Raising Contributions from Individual Donors to NCAA Division I-A Institutions

ERIC Educational Resources Information Center

Wells, Douglas E.; Southall, Richard M.; Stotlar, David; Mundfrom, Daniel J.

2005-01-01

The purpose of this study was to identify selected factors related to annual fundraising program contributions at National Collegiate Athletic Association (NCAA) Division I-A (D I-A) institutions and develop an equation for estimating an annual fund-raising goal. Based on a review of the literature, 15 potential predictor variables were selected…

Cell division plane orientation based on tensile stress in Arabidopsis thaliana

PubMed Central

Louveaux, Marion; Julien, Jean-Daniel; Mirabet, Vincent; Boudaoud, Arezki; Hamant, Olivier

2016-01-01

Cell geometry has long been proposed to play a key role in the orientation of symmetric cell division planes. In particular, the recently proposed Besson–Dumais rule generalizes Errera’s rule and predicts that cells divide along one of the local minima of plane area. However, this rule has been tested only on tissues with rather local spherical shape and homogeneous growth. Here, we tested the application of the Besson–Dumais rule to the divisions occurring in the Arabidopsis shoot apex, which contains domains with anisotropic curvature and differential growth. We found that the Besson–Dumais rule works well in the central part of the apex, but fails to account for cell division planes in the saddle-shaped boundary region. Because curvature anisotropy and differential growth prescribe directional tensile stress in that region, we tested the putative contribution of anisotropic stress fields to cell division plane orientation at the shoot apex. To do so, we compared two division rules: geometrical (new plane along the shortest path) and mechanical (new plane along maximal tension). The mechanical division rule reproduced the enrichment of long planes observed in the boundary region. Experimental perturbation of mechanical stress pattern further supported a contribution of anisotropic tensile stress in division plane orientation. Importantly, simulations of tissues growing in an isotropic stress field, and dividing along maximal tension, provided division plane distributions comparable to those obtained with the geometrical rule. We thus propose that division plane orientation by tensile stress offers a general rule for symmetric cell division in plants. PMID:27436908

The SPOR Domain, a Widely Conserved Peptidoglycan Binding Domain That Targets Proteins to the Site of Cell Division.

PubMed

Yahashiri, Atsushi; Jorgenson, Matthew A; Weiss, David S

2017-07-15

Sporulation-related repeat (SPOR) domains are small peptidoglycan (PG) binding domains found in thousands of bacterial proteins. The name "SPOR domain" stems from the fact that several early examples came from proteins involved in sporulation, but SPOR domain proteins are quite diverse and contribute to a variety of processes that involve remodeling of the PG sacculus, especially with respect to cell division. SPOR domains target proteins to the division site by binding to regions of PG devoid of stem peptides ("denuded" glycans), which in turn are enriched in septal PG by the intense, localized activity of cell wall amidases involved in daughter cell separation. This targeting mechanism sets SPOR domain proteins apart from most other septal ring proteins, which localize via protein-protein interactions. In addition to SPOR domains, bacteria contain several other PG-binding domains that can exploit features of the cell wall to target proteins to specific subcellular sites. Copyright © 2017 American Society for Microbiology.

Biology Division progress report, October 1, 1991--September 30, 1993

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hartman, F.C.; Cook, J.S.

This Progress Report summarizes the research endeavors of the Biology Division of the Oak Ridge National Laboratory during the period October 1, 1991, through September 30, 1993. The report is structured to provide descriptions of current activities and accomplishments in each of the Division`s major organizational units. Lists of information to convey the entire scope of the Division`s activities are compiled at the end of the report.

Recent advances in understanding oogenesis: interactions with the cytoskeleton, microtubule organization, and meiotic spindle assembly in oocytes

PubMed Central

Marlow, Florence L.

2018-01-01

Maternal control of development begins with production of the oocyte during oogenesis. All of the factors necessary to complete oocyte maturation, meiosis, fertilization, and early development are produced in the transcriptionally active early oocyte. Active transcription of the maternal genome is a mechanism to ensure that the oocyte and development of the early embryo begin with all of the factors needed for successful embryonic development. To achieve the maximum maternal store, only one functional cell is produced from the meiotic divisions that produce the oocyte. The oocyte receives the bulk of the maternal cytoplasm and thus is significantly larger than its sister cells, the tiny polar bodies, which receive a copy of the maternal genome but essentially none of the maternal cytoplasm. This asymmetric division is accomplished by an enormous cell that is depleted of centrosomes in early oogenesis; thus, meiotic divisions in oocytes are distinct from those of mitotic cells. Therefore, these cells must partition the chromosomes faithfully to ensure euploidy by using mechanisms that do not rely on a conventional centrosome-based mitotic spindle. Several mechanisms that contribute to assembly and maintenance of the meiotic spindle in oocytes have been identified; however, none is fully understood. In recent years, there have been many exciting and significant advances in oogenesis, contributed by studies using a myriad of systems. Regrettably, I cannot adequately cover all of the important advances here and so I apologize to those whose beautiful work has not been included. This review focuses on a few of the most recent studies, conducted by several groups, using invertebrate and vertebrate systems, that have provided mechanistic insight into how microtubule assembly and meiotic spindle morphogenesis are controlled in the absence of centrosomes.

Engineering physics and mathematics division

NASA Astrophysics Data System (ADS)

Sincovec, R. F.

1995-07-01

This report provides a record of the research activities of the Engineering Physics and Mathematics Division for the period 1 Jan. 1993 - 31 Dec. 1994. This report is the final archival record of the EPM Division. On 1 Oct. 1994, ORELA was transferred to Physics Division and on 1 Jan. 1995, the Engineering Physics and Mathematics Division and the Computer Applications Division reorganized to form the Computer Science and Mathematics Division and the Computational Physics and Engineering Division. Earlier reports in this series are identified on the previous pages, along with the progress reports describing ORNL's research in the mathematical sciences prior to 1984 when those activities moved into the Engineering Physics and Mathematics Division.

Division Quilts: A Measurement Model

ERIC Educational Resources Information Center

Pratt, Sarah S.; Lupton, Tina M.; Richardson, Kerri

2015-01-01

As teachers seek activities to assist students in understanding division as more than just the algorithm, they find many examples of division as fair sharing. However, teachers have few activities to engage students in a quotative (measurement) model of division. Efraim Fischbein and his colleagues (1985) defined two types of whole-number…

The impact of corporate social responsibility and employees' perception on participating and contributing to charitable programs

NASA Astrophysics Data System (ADS)

Allen, Belinda A.

The goal for this research was to understand the perceptions of employees regarding a company's corporate social responsibility (CSR). The specific goal was to discover and understand the level of employee giving to corporate CSR initiatives. In this instance, the fund was a corporate fund for community development program. A qualitative, single-case-study was conducted at a specific division of an aerospace corporation. The topic was explored through an analysis of employee perceptions about advertisement, trust, campaigns, and CSR engagement. Data collection included a pilot study, one-on-one private interviews, and a focus group. The results indicated that (a) the corporation can be a model company for CSR programs, and (b) employees at the specific division under study want to become aware and play their part in bringing about social change. However, the findings indicated that the division must become more visible with its CSR activities. It is through CSR commitment and strategies that the corporation seeks to be a good corporate citizen, which is carried out in collaboration with its employees. The results indicated that employees felt that increased awareness through annual campaign drives and advertisement throughout the year would strengthen giving to the CFCD program and would allow employees to be more engaged in CSR activities.

Asymmetric segregation and self-renewal of hematopoietic stem and progenitor cells with endocytic Ap2a2.

PubMed

Ting, Stephen B; Deneault, Eric; Hope, Kristin; Cellot, Sonia; Chagraoui, Jalila; Mayotte, Nadine; Dorn, Jonas F; Laverdure, Jean-Philippe; Harvey, Michael; Hawkins, Edwin D; Russell, Sarah M; Maddox, Paul S; Iscove, Norman N; Sauvageau, Guy

2012-03-15

The stem cell-intrinsic model of self-renewal via asymmetric cell division (ACD) posits that fate determinants be partitioned unequally between daughter cells to either activate or suppress the stemness state. ACD is a purported mechanism by which hematopoietic stem cells (HSCs) self-renew, but definitive evidence for this cellular process remains open to conjecture. To address this issue, we chose 73 candidate genes that function within the cell polarity network to identify potential determinants that may concomitantly alter HSC fate while also exhibiting asymmetric segregation at cell division. Initial gene-expression profiles of polarity candidates showed high and differential expression in both HSCs and leukemia stem cells. Altered HSC fate was assessed by our established in vitro to in vivo screen on a subcohort of candidate polarity genes, which revealed 6 novel positive regulators of HSC function: Ap2a2, Gpsm2, Tmod1, Kif3a, Racgap1, and Ccnb1. Interestingly, live-cell videomicroscopy of the endocytic protein AP2A2 shows instances of asymmetric segregation during HSC/progenitor cell cytokinesis. These results contribute further evidence that ACD is functional in HSC self-renewal, suggest a role for Ap2a2 in HSC activity, and provide a unique opportunity to prospectively analyze progeny from HSC asymmetric divisions.

IFLA General Conference 1988. Division of Special Libraries. Section on Science and Technology Libraries; Section on Art Libraries; Section on Social Science Libraries; Section on Geography and Map Libraries; Division of Contributed Papers.

ERIC Educational Resources Information Center

International Federation of Library Associations, The Hague (Netherlands).

The 23 papers in this collection include papers on special libraries and miscellaneous contributed papers: (1) "Networking Potentialities and Limitations--Special Library Networks in Socialist Countries--An Overview, and the Main Ways of Perestroika in the Work of Scientific and Technical Libraries at the Present Stage" (D. Schmidmaier…

Intra-lineage Fate Decisions Involve Activation of Notch Receptors Basal to the Midbody in Drosophila Sensory Organ Precursor Cells.

PubMed

Trylinski, Mateusz; Mazouni, Khalil; Schweisguth, François

2017-08-07

Notch receptors regulate cell fate decisions during embryogenesis and throughout adult life. In many cell lineages, binary fate decisions are mediated by directional Notch signaling between the two sister cells produced by cell division. How Notch signaling is restricted to sister cells after division to regulate intra-lineage decision is poorly understood. More generally, where ligand-dependent activation of Notch occurs at the cell surface is not known, as methods to detect receptor activation in vivo are lacking. In Drosophila pupae, Notch signals during cytokinesis to regulate the intra-lineage pIIa/pIIb decision in the sensory organ lineage. Here, we identify two pools of Notch along the pIIa-pIIb interface, apical and basal to the midbody. Analysis of the dynamics of Notch, Delta, and Neuralized distribution in living pupae suggests that ligand endocytosis and receptor activation occur basal to the midbody. Using selective photo-bleaching of GFP-tagged Notch and photo-tracking of photo-convertible Notch, we show that nuclear Notch is indeed produced by receptors located basal to the midbody. Thus, only a specific subset of receptors, located basal to the midbody, contributes to signaling in pIIa. This is the first in vivo characterization of the pool of Notch contributing to signaling. We propose a simple mechanism of cell fate decision based on intra-lineage signaling: ligands and receptors localize during cytokinesis to the new cell-cell interface, thereby ensuring signaling between sister cells, hence intra-lineage fate decision. Copyright © 2017 Elsevier Ltd. All rights reserved.

Differential impacts of FtsZ proteins on plastid division in the shoot apex of Arabidopsis.

PubMed

Swid, Neora; Nevo, Reinat; Kiss, Vladimir; Kapon, Ruti; Dagan, Shlomi; Snir, Orli; Adam, Zach; Falconet, Denis; Reich, Ziv; Charuvi, Dana

2018-06-16

FtsZ proteins of the FtsZ1 and FtsZ2 families play important roles in the initiation and progression of plastid division in plants and green algae. Arabidopsis possesses a single FTSZ1 member and two FTSZ2 members, FTSZ2-1 and FTSZ2-2. The contribution of these to chloroplast division and partitioning has been mostly investigated in leaf mesophyll tissues. Here, we assessed the involvement of the three FtsZs in plastid division at earlier stages of chloroplast differentiation. To this end, we studied the effect of the absence of specific FtsZ proteins on plastids in the vegetative shoot apex, where the proplastid-to-chloroplast transition takes place. We found that the relative contribution of the two major leaf FtsZ isoforms, FtsZ1 and FtsZ2-1, to the division process varies with cell lineage and position within the shoot apex. While FtsZ2-1 dominates division in the L1 and L3 layers of the shoot apical meristem (SAM), in the L2 layer, FtsZ1 and FtsZ2-1 contribute equally toward the process. Depletion of the third isoform, FtsZ2-2, generally resulted in stronger effects in the shoot apex than those observed in mature leaves. The implications of these findings, along with additional observations made in this work, to our understanding of the mechanisms and regulation of plastid proliferation in the shoot apex are discussed. Copyright © 2018. Published by Elsevier Inc.

GREENHOUSE GASES (ATMOSPHERIC PROTECTION BRANCH, AIR POLLUTION PREVENTION AND CONTROL DIVISION, NRMRL)

EPA Science Inventory

Greenhouse gas (GHG) emissions are projected for various scenarios and the most appropriate approaches and technologies for mitigation are identified by NRMRL's Air Pollution Prevention and Control Division's Atmospheric Protection Branch (APB). These methods contribute to reduct...

Auxin-Dependent Cell Division and Cell Elongation. 1-Naphthaleneacetic Acid and 2,4-Dichlorophenoxyacetic Acid Activate Different Pathways1

PubMed Central

Campanoni, Prisca; Nick, Peter

2005-01-01

During exponential phase, the tobacco (Nicotiana tabacum) cell line cv Virginia Bright Italia-0 divides axially to produce linear cell files of distinct polarity. This axial division is controlled by exogenous auxin. We used exponential tobacco cv Virginia Bright Italia-0 cells to dissect early auxin signaling, with cell division and cell elongation as physiological markers. Experiments with 1-naphthaleneacetic acid (NAA) and 2,4-dichlorophenoxyacetic acid (2,4-D) demonstrated that these 2 auxin species affect cell division and cell elongation differentially; NAA stimulates cell elongation at concentrations that are much lower than those required to stimulate cell division. In contrast, 2,4-D promotes cell division but not cell elongation. Pertussis toxin, a blocker of heterotrimeric G-proteins, inhibits the stimulation of cell division by 2,4-D but does not affect cell elongation. Aluminum tetrafluoride, an activator of the G-proteins, can induce cell division at NAA concentrations that are not permissive for division and even in the absence of any exogenous auxin. The data are discussed in a model where the two different auxins activate two different pathways for the control of cell division and cell elongation. PMID:15734918

Mechanical stretch triggers rapid epithelial cell division through Piezo1.

PubMed

Gudipaty, S A; Lindblom, J; Loftus, P D; Redd, M J; Edes, K; Davey, C F; Krishnegowda, V; Rosenblatt, J

2017-03-02

Despite acting as a barrier for the organs they encase, epithelial cells turn over at some of the fastest rates in the body. However, epithelial cell division must be tightly linked to cell death to preserve barrier function and prevent tumour formation. How does the number of dying cells match those dividing to maintain constant numbers? When epithelial cells become too crowded, they activate the stretch-activated channel Piezo1 to trigger extrusion of cells that later die. However, it is unclear how epithelial cell division is controlled to balance cell death at the steady state. Here we show that mammalian epithelial cell division occurs in regions of low cell density where cells are stretched. By experimentally stretching epithelia, we find that mechanical stretch itself rapidly stimulates cell division through activation of the Piezo1 channel. To stimulate cell division, stretch triggers cells that are paused in early G2 phase to activate calcium-dependent phosphorylation of ERK1/2, thereby activating the cyclin B transcription that is necessary to drive cells into mitosis. Although both epithelial cell division and cell extrusion require Piezo1 at the steady state, the type of mechanical force controls the outcome: stretch induces cell division, whereas crowding induces extrusion. How Piezo1-dependent calcium transients activate two opposing processes may depend on where and how Piezo1 is activated, as it accumulates in different subcellular sites with increasing cell density. In sparse epithelial regions in which cells divide, Piezo1 localizes to the plasma membrane and cytoplasm, whereas in dense regions in which cells extrude, it forms large cytoplasmic aggregates. Because Piezo1 senses both mechanical crowding and stretch, it may act as a homeostatic sensor to control epithelial cell numbers, triggering extrusion and apoptosis in crowded regions and cell division in sparse regions.

What Contributes to the (Im)Balanced Division of Family Work Between the Sexes?

PubMed Central

Lothaller, Harald; Mikula, Gerold; Schoebi, Dominik

2011-01-01

This study examines a comprehensive set of variables that have been proposed as explaining the imbalance of the division of family work between the sexes. The analyses use survey data of 735 dual-earner couples from Austria, the Netherlands, and Portugal. The results support theoretical explanations referring to time availability, gender ideology, relative resources, and the importance of characteristics of the family system. No support was obtained for the doing-gender perspective. Additional findings suggest that increased consideration of psychological concepts adds to the understanding of why women do more family work than men. The analyses revealed similarities, but also differences between the factors that contribute to the division of household labor and childcare. PMID:22318972

Counting women's work in the agricultural census of Nepal: a report.

PubMed

Joshi, S

2000-01-01

Like many national statistical surveys, the Agricultural Census of Nepal does not reflect the actual contribution of women's work in agriculture. Inadequacies in conceptualization, definition of terms and data gathering methods result in undervaluation and underrepresentation of women's work. This study of 124 Newar households in the Lubhu Village Development Committee, Kathmandu Valley, provides a statistical representation of women's roles in agricultural operations and household activities by assessing the actual extent of their work. After analyzing the gender division of labor, the study concludes that women's work in agriculture and household activities is significantly higher than men's work.

Division of labour between Myc and G1 cyclins in cell cycle commitment and pace control.

PubMed

Dong, Peng; Maddali, Manoj V; Srimani, Jaydeep K; Thélot, François; Nevins, Joseph R; Mathey-Prevot, Bernard; You, Lingchong

2014-09-01

A body of evidence has shown that the control of E2F transcription factor activity is critical for determining cell cycle entry and cell proliferation. However, an understanding of the precise determinants of this control, including the role of other cell-cycle regulatory activities, has not been clearly defined. Here, recognizing that the contributions of individual regulatory components could be masked by heterogeneity in populations of cells, we model the potential roles of individual components together with the use of an integrated system to follow E2F dynamics at the single-cell level and in real time. These analyses reveal that crossing a threshold amplitude of E2F accumulation determines cell cycle commitment. Importantly, we find that Myc is critical in modulating the amplitude, whereas cyclin D/E activities have little effect on amplitude but do contribute to the modulation of duration of E2F activation, thereby affecting the pace of cell cycle progression.

75 FR 45154 - National Security Division; Agency Information Collection Activities:

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-02

... DEPARTMENT OF JUSTICE [OMB Number 1124-0003] National Security Division; Agency Information Collection Activities: Proposed Collection; Comments Requested ACTION: 60-Day Notice of Information...), National Security Division (NSD), will be submitting the following information collection request to the...

Instrumentation and Controls Division progress report, July 1, 1990--June 30, 1992. Volume 2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1993-01-01

This report contains the following information from the Instrumentation and Controls Division of Oak Ridge National Laboratory: supplementary activities; seminars; publications and presentations; scientific and professional activities, achievements, and awards; and division organization charts.

75 FR 2878 - National Cancer Institute; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-19

..., Resources and Training Review Branch, Division of Extramural Activities, National Cancer Institute, 6116... Officer, Research Programs Review Branch, Division of Extramural Activities, National Cancer Institute... Ahmad, PhD, Scientific Review Officer, Research Programs Review Branch, Division of Extramural...

75 FR 10295 - National Cancer Institute; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-05

... G. Lovinger, PhD, Scientific Review Administrator, Special Review and Logistics Branch, Division of... Branch, Division of Extramural Activities, National Cancer Institute, 6116 Executive Boulevard, Room 7142... and Referral Branch, Division of Extramural Activities, National Cancer Institute, NIH, 6116 Executive...

From centriole biogenesis to cellular function: centrioles are essential for cell division at critical developmental stages.

PubMed

Rodrigues-Martins, Ana; Riparbelli, Maria; Callaini, Giuliano; Glover, David M; Bettencourt-Dias, Monica

2008-01-01

Centrioles are essential for the formation of cilia, flagella and centrosome organization. Abnormalities in centrosome structure and number in many cancers can be associated with aberrant cell division and genomic instability.(1,2) Canonical centriole duplication occurs in coordination with the cell division cycle, such that a single new "daughter" centriole arises next to each "mother" centriole. If destroyed, or eliminated during development, centrioles can form de novo.(3-5) Here we discuss our recent data demonstrating a molecular pathway that operates in both de novo and canonical centriole biogenesis involving SAK/PLK4, SAS-6 and SAS-4.(6) We showed that centriole biogenesis is a self-assembly process locally triggered by high SAK/PLK4 activity that may or not be associated with an existing centriole. SAS-6 acts downstream of SAK/PLK4 to organize nine precentriolar units, which we call here enatosomes, fitting together laterally and longitudinally, specifying a tube-like centriole precursor.(7,8) The identification of mutants impaired in centriole biogenesis has permitted the study of the physiological consequences of their absence in the whole organism. In Drosophila, centrioles are not necessary for somatic cell divisions.(9,10) However, we show here that mitotic abnormalities arise in syncytial SAK/PLK4-derived mutant embryos resulting in lethality. Moreover male meiosis fails in both SAK/PLK4 and DSAS-4 mutant spermatids that have no centrioles. These results show diversity in the need for centrioles in cell division. This suggests that tissue specific constraints selected for different contributions of centrosome-independent and dependent mechanisms in spindle function. This heterogeneity should be taken into account both in reaching an understanding of spindle function and when designing drugs that target cell division.

Competing Biases in Mental Arithmetic: When Division Is More and Multiplication Is Less.

PubMed

Shaki, Samuel; Fischer, Martin H

2017-01-01

Mental arithmetic exhibits various biases. Among those is a tendency to overestimate addition and to underestimate subtraction outcomes. Does such "operational momentum" (OM) also affect multiplication and division? Twenty-six adults produced lines whose lengths corresponded to the correct outcomes of multiplication and division problems shown in symbolic format. We found a reliable tendency to over-estimate division outcomes, i.e., reverse OM. We suggest that anchoring on the first operand (a tendency to use this number as a reference for further quantitative reasoning) contributes to cognitive biases in mental arithmetic.

Metals and Ceramics Division progress report for period ending December 31, 1993

DOE Office of Scientific and Technical Information (OSTI.GOV)

Craig, D.F.; Bradley, R.A.; Weir, J.R. Jr.

1994-07-01

This report provides an overview of activities and accomplishsments of the division from October 1992 through December 1993; the division is organized to provide technical support, mainly in the area of high-temperature materials, for technologies being developed by DOE. Activities span the range from basic research to industrial interactions (cooperative research and technology transfer). Sections 1-5 describe the different functional groups (engineering materials, high-temperature materials, materials science, ceramics, nuclear fuel materials). Sect. 6 provides an alternative view of the division in terms of the major programs, most of which cross group lines. Sect. 7 summarizes external interactions including cooperative Rmore » and D programs and technology transfer functions. Finally, Sect. 8 briefly describes the division`s involvement in educational activities. Several organizational changes were effected during this period.« less

Pre-Activity and Post-Activity Stretching Perceptions and Practices in NCAA Division I Volleyball Programs

ERIC Educational Resources Information Center

Judge, Lawrence W.; Bodey, Kimberly J.; Bellar, David; Bottone, Adam; Wanless, Elizabeth

2010-01-01

The purpose of this study was to determine if NCAA Division I women's volleyball programs were in compliance with suggested current pre- and post-activity stretching protocols. Questionnaires were sent to NCAA division I women's volleyball programs in the United States. Fifty six coaches (23 males & 33 females) participated in the study. Some…

Lewis materials research and technology: An overview

NASA Technical Reports Server (NTRS)

Grisaffe, Salvatore J.

1987-01-01

The Materials Division at the Lewis Research Center has a long record of contributions to both materials and process technology as well as to the understanding of key high-temperature phenomena. An overview of the division staff, facilities, past history, recent progress, and future interests is presented.

NASA. Lewis Research Center materials research and technology: An overview

NASA Technical Reports Server (NTRS)

Grisaffe, Salvatore J.

1990-01-01

The Materials Division at the Lewis Research Center has a long record of contributions to both materials and process technology as well as to the understanding of key high-temperature phenomena. This paper overviews the division staff, facilities, past history, recent progress, and future interests.

Dissecting hemisphere-specific contributions to visual spatial imagery using parametric brain mapping.

PubMed

Bien, Nina; Sack, Alexander T

2014-07-01

In the current study we aimed to empirically test previously proposed accounts of a division of labour between the left and right posterior parietal cortices during visuospatial mental imagery. The representation of mental images in the brain has been a topic of debate for several decades. Although the posterior parietal cortex is involved bilaterally, previous studies have postulated that hemispheric specialisation might result in a division of labour between the left and right parietal cortices. In the current fMRI study, we used an elaborated version of a behaviourally-controlled spatial imagery paradigm, the mental clock task, which involves mental image generation and a subsequent spatial comparison between two angles. By systematically varying the difference between the two angles that are mentally compared, we induced a symbolic distance effect: smaller differences between the two angles result in higher task difficulty. We employed parametrically weighed brain imaging to reveal brain areas showing a graded activation pattern in accordance with the induced distance effect. The parametric difficulty manipulation influenced behavioural data and brain activation patterns in a similar matter. Moreover, since this difficulty manipulation only starts to play a role from the angle comparison phase onwards, it allows for a top-down dissociation between the initial mental image formation, and the subsequent angle comparison phase of the spatial imagery task. Employing parametrically weighed fMRI analysis enabled us to top-down disentangle brain activation related to mental image formation, and activation reflecting spatial angle comparison. The results provide first empirical evidence for the repeatedly proposed division of labour between the left and right posterior parietal cortices during spatial imagery. Copyright © 2014 Elsevier Inc. All rights reserved.

Activities of the United States Geological Survey in Pennsylvania

USGS Publications Warehouse

Wood, Charles R.

1997-01-01

Since the late 1800's, when the U.S. Geological Survey first established a presence in Pennsylvania, the focus of our work has changed from general hydrologic and geologic appraisals to issue-oriented investigations; from predominantly data collection to a balanced program of data collection, interpretation, and research; and from traditional, hand-drawn mapping to digitally produced coverages with specialized themes. Yet our basic mission has not changed. It is as relevant to the resource issues of today as it was when our geologists first arrived in western Pennsylvania in 1884. Continuing in this proud heritage and tradition, the U.S. Geological Survey is moving confidently toward the next century, evolving organizationally and technologically to better meet the needs of our many constituencies. One major organizational change is the recent accession of employees from the former National Biological Service, who now form the Survey's fourth program division, the Biological Resources Division. These employees join forces with colleagues in our other three divisions: Water Resources, Geologic, and National Mapping. More than any other change in decades, the addition of this biological expertise creates new and exciting opportunities for scientific research and public service. This report provides an overview of recent activities in Pennsylvania conducted by the four program divisions and is intended to inform those interested in U.S. Geological Survey products and services. Additional information is available on our home page (at http://wwwpah2o.er.usgs.gov/). Together with numerous Federal, State, and local agencies and organizations who are our customers and partners, we at the U.S. Geological Survey look forward to providing continued scientific contributions and public service to Pennsylvania and the Nation.

Introduction to the special issue: 50th anniversary of APA Division 28: The past, present, and future of psychopharmacology and substance abuse.

PubMed

Stoops, William W; Sigmon, Stacey C; Evans, Suzette M

2016-08-01

This is an introduction to the special issue "50th Anniversary of APA Division 28: The Past, Present, and Future of Psychopharmacology and Substance Abuse." Taken together, the scholarly contributions included in this special issue serve as a testament to the important work conducted by our colleagues over the past five decades. Division 28 and its members have advanced and disseminated knowledge on the behavioral effects of drugs, informed efforts to prevent and treat substance abuse, and influenced education and policy issues more generally. As past and current leaders of the division, we are excited to celebrate 50 years of Division 28 and look forward to many more successful decades for our division and its members. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

Alaska Division of Retirement and Benefits

Science.gov Websites

Enrollment Retiree News View All Headlines Legislation Programs Defined Contribution Defined Benefit Health ; Brochures Division Headlines Get My RIN ADA Accessibility Retiree Health Plan Advisory Board Welcome to and TRS CAFRs are now available online. 2017 CAFR Health and Wellness Services The Coalition Health

Control of the mitotic exit network during meiosis

PubMed Central

Attner, Michelle A.; Amon, Angelika

2012-01-01

The mitotic exit network (MEN) is an essential GTPase signaling pathway that triggers exit from mitosis in budding yeast. We show here that during meiosis, the MEN is dispensable for exit from meiosis I but contributes to the timely exit from meiosis II. Consistent with a role for the MEN during meiosis II, we find that the signaling pathway is active only during meiosis II. Our analysis further shows that MEN signaling is modulated during meiosis in several key ways. Whereas binding of MEN components to spindle pole bodies (SPBs) is necessary for MEN signaling during mitosis, during meiosis MEN signaling occurs off SPBs and does not require the SPB recruitment factor Nud1. Furthermore, unlike during mitosis, MEN signaling is controlled through the regulated interaction between the MEN kinase Dbf20 and its activating subunit Mob1. Our data lead to the conclusion that a pathway essential for vegetative growth is largely dispensable for the specialized meiotic divisions and provide insights into how cell cycle regulatory pathways are modulated to accommodate different modes of cell division. PMID:22718910

A cytokinesis checkpoint requiring the yeast homologue of an APC-binding protein

PubMed Central

Muhua, Li; Adames, Neil R.; Murphy, Michael D.; Shields, Colleen R.; Cooper, John A.

2008-01-01

Checkpoint controls ensure that events of the cell-division cycle are completed with fidelity and in the correct order. In budding yeast with a mutation in the motor protein dynein, the mitotic spindle is often misaligned and therefore slow to enter the neck between mother cell and budding daughter cell. When this occurs, cytokinesis (division of the cytoplasm into two) is delayed until the spindle is properly positioned1. Here we describe mutations that abolish this delay, indicating the existence of a new checkpoint mechanism. One mutation lies in the gene encoding the yeast homologue of EB1, a human protein that binds the adenomatous polyposis coli (APC) protein, a tumour suppressor. EB1 is located on microtubules of the mitotic spindle and is important in spindle assembly. EB1 may therefore, by associating with microtubules, contribute to the sensor mechanism that activates the checkpoint. Another mutation affects Stt4, a phosphatidylinositol-4-OH kinase. Cold temperature is an environmental stimulus that causes misalignment of the mitotic spindle in yeast and appears to activate this checkpoint mechanism. PMID:9624007

The putative hydrolase YycJ (WalJ) affects the coordination of cell division with DNA replication in Bacillus subtilis and may play a conserved role in cell wall metabolism.

PubMed

Biller, Steven J; Wayne, Kyle J; Winkler, Malcolm E; Burkholder, William F

2011-02-01

Bacteria must accurately replicate and segregate their genetic information to ensure the production of viable daughter cells. The high fidelity of chromosome partitioning is achieved through mechanisms that coordinate cell division with DNA replication. We report that YycJ (WalJ), a predicted member of the metallo-β-lactamase superfamily found in most low-G+C Gram-positive bacteria, contributes to the fidelity of cell division in Bacillus subtilis. B. subtilis ΔwalJ (ΔwalJ(Bsu)) mutants divide over unsegregated chromosomes more frequently than wild-type cells, and this phenotype is exacerbated when DNA replication is inhibited. Two lines of evidence suggest that WalJ(Bsu) and its ortholog in the Gram-positive pathogen Streptococcus pneumoniae, WalJ(Spn) (VicX), play a role in cell wall metabolism: (i) strains of B. subtilis and S. pneumoniae lacking walJ exhibit increased sensitivity to a narrow spectrum of cephalosporin antibiotics, and (ii) reducing the expression of a two-component system that regulates genes involved in cell wall metabolism, WalRK (YycFG), renders walJ essential for growth in B. subtilis, as observed previously with S. pneumoniae. Together, these results suggest that the enzymatic activity of WalJ directly or indirectly affects cell wall metabolism and is required for accurate coordination of cell division with DNA replication.

GSFC Heliophysics Science Division FY2010 Annual Report

NASA Technical Reports Server (NTRS)

Gilbert, Holly R.; Strong, Keith T.; Saba, Julia L. R.; Clark, Judith B.; Kilgore, Robert W.; Strong, Yvonne M.

2010-01-01

This report is intended to record and communicate to our colleagues, stakeholders, and the public at large about heliophysics scientific and flight program achievements and milestones for 2010, for which NASA Goddard Space Flight Center's Heliophysics Science Division (HSD) made important contributions. HSD comprises approximately 323 scientists, technologists, and administrative personnel dedicated to the goal of advancing our knowledge and understanding of the Sun and the wide variety of domains that its variability influences. Our activities include: Leading science investigations involving flight hardware, theory, and data analysis and modeling that will answer the strategic questions posed in the Heliophysics Roadmap; Leading the development of new solar and space physics mission concepts and support their implementation as Project Scientists; Providing access to measurements from the Heliophysics Great Observatory through our Science Information Systems; and Communicating science results to the public and inspiring the next generation of scientists and explorers.

GSFC Heliophysics Science Division 2008 Science Highlights

NASA Technical Reports Server (NTRS)

Gilbert, Holly R.; Strong, Keith T.; Saba, Julia L. R.; Firestone, Elaine R.

2009-01-01

This report is intended to record and communicate to our colleagues, stakeholders, and the public at large about heliophysics scientific and flight program achievements and milestones for 2008, for which NASA Goddard Space Flight Center's Heliophysics Science Division (HSD) made important contributions. HSD comprises approximately 261 scientists, technologists, and administrative personnel dedicated to the goal of advancing our knowledge and understanding of the Sun and the wide variety of domains that its variability influences. Our activities include Lead science investigations involving flight hardware, theory, and data analysis and modeling that will answer the strategic questions posed in the Heliophysics Roadmap; Lead the development of new solar and space physics mission concepts and support their implementation as Project Scientists; Provide access to measurements from the Heliophysics Great Observatory through our Science Information Systems, and Communicate science results to the public and inspire the next generation of scientists and explorers.

GSFC Heliophysics Science Division 2009 Science Highlights

NASA Technical Reports Server (NTRS)

Strong, Keith T.; Saba, Julia L. R.; Strong, Yvonne M.

2009-01-01

This report is intended to record and communicate to our colleagues, stakeholders, and the public at large about heliophysics scientific and flight program achievements and milestones for 2009, for which NASA Goddard Space Flight Center's Heliophysics Science Division (HSD) made important contributions. HSD comprises approximately 299 scientists, technologists, and administrative personnel dedicated to the goal of advancing our knowledge and understanding of the Sun and the wide variety of domains that its variability influences. Our activities include: Leading science investigations involving flight hardware, theory, and data analysis and modeling that will answer the strategic questions posed in the Heliophysics Roadmap; Leading the development of new solar and space physics mission concepts and support their implementation as Project Scientists; Providing access to measurements from the Heliophysics Great Observatory through our Science Information Systems; and Communicating science results to the public and inspiring the next generation of scientists and explorers.

Some Words about John Hall

NASA Astrophysics Data System (ADS)

Faller, James E.

Jan, whose 70th birthday and scientific contributions we celebrate today, was a founding (charter) member of the Joint Institute for Laboratory Astrophysics (now JILA). He came in July of 1961 as a National Research Council Postdoctoral Fellow to the National Bureau of Standards (jointing the Atomic Physics Division) in Washington. A year later he came to Boulder with the contingency from that Division who constituted the bulk of the Federal Government's scientific staff contribution to the Joint Institute. Midway during Jan's first year at JILA he was made a regular NBS employee…

Urban sprawl and you: how sprawl adversely affects worker health.

PubMed

Pohanka, Mary; Fitzgerald, Sheila

2004-06-01

Urban sprawl, once thought of as just an environmental issue, is currently gaining momentum as an emerging public health issue worthy of research and political attention. Characteristics seen in sprawling communities include increasing traffic volumes; inadequate public transportation; pedestrian unfriendly streets; and the division of businesses, shops, and homes. These characteristics can affect health in many ways. Greater air pollution contributes to higher asthma and other lung disorder rates. An increased dependence on the automobile encourages a more sedentary lifestyle and can potentially contribute to obesity. The increased danger and stress of long commutes can lead to more accidents, anxiety, and social isolation. Occupational health nurses can become involved by promoting physical activity in the workplace, creating programs for injury prevention and stress management, becoming involved in political smart growth measures, and educating and encouraging colleagues to become active in addressing this issue.

Myc/Mycn-mediated glycolysis enhances mouse spermatogonial stem cell self-renewal

PubMed Central

Kanatsu-Shinohara, Mito; Tanaka, Takashi; Ogonuki, Narumi; Ogura, Atsuo; Morimoto, Hiroko; Cheng, Pei Feng; Eisenman, Robert N.; Trumpp, Andreas; Shinohara, Takashi

2016-01-01

Myc plays critical roles in the self-renewal division of various stem cell types. In spermatogonial stem cells (SSCs), Myc controls SSC fate decisions because Myc overexpression induces enhanced self-renewal division, while depletion of Max, a Myc-binding partner, leads to meiotic induction. However, the mechanism by which Myc acts on SSC fate is unclear. Here we demonstrate a critical link between Myc/Mycn gene activity and glycolysis in SSC self-renewal. In SSCs, Myc/Mycn are regulated by Foxo1, whose deficiency impairs SSC self-renewal. Myc/Mycn-deficient SSCs not only undergo limited self-renewal division but also display diminished glycolytic activity. While inhibition of glycolysis decreased SSC activity, chemical stimulation of glycolysis or transfection of active Akt1 or Pdpk1 (phosphoinositide-dependent protein kinase 1 ) augmented self-renewal division, and long-term SSC cultures were derived from a nonpermissive strain that showed limited self-renewal division. These results suggested that Myc-mediated glycolysis is an important factor that increases the frequency of SSC self-renewal division. PMID:28007786

Myc/Mycn-mediated glycolysis enhances mouse spermatogonial stem cell self-renewal.

PubMed

Kanatsu-Shinohara, Mito; Tanaka, Takashi; Ogonuki, Narumi; Ogura, Atsuo; Morimoto, Hiroko; Cheng, Pei Feng; Eisenman, Robert N; Trumpp, Andreas; Shinohara, Takashi

2016-12-01

Myc plays critical roles in the self-renewal division of various stem cell types. In spermatogonial stem cells (SSCs), Myc controls SSC fate decisions because Myc overexpression induces enhanced self-renewal division, while depletion of Max, a Myc-binding partner, leads to meiotic induction. However, the mechanism by which Myc acts on SSC fate is unclear. Here we demonstrate a critical link between Myc/Mycn gene activity and glycolysis in SSC self-renewal. In SSCs, Myc/Mycn are regulated by Foxo1, whose deficiency impairs SSC self-renewal. Myc/Mycn-deficient SSCs not only undergo limited self-renewal division but also display diminished glycolytic activity. While inhibition of glycolysis decreased SSC activity, chemical stimulation of glycolysis or transfection of active Akt1 or Pdpk1 (phosphoinositide-dependent protein kinase 1 ) augmented self-renewal division, and long-term SSC cultures were derived from a nonpermissive strain that showed limited self-renewal division. These results suggested that Myc-mediated glycolysis is an important factor that increases the frequency of SSC self-renewal division. © 2016 Kanatsu-Shinohara et al.; Published by Cold Spring Harbor Laboratory Press.

NCI Designated Cancer Centers

MedlinePlus

... NCI NCI Overview History Contributing to Cancer Research Leadership Director's Page Deputy Director's Page Previous NCI Directors ... History of NCI Contributing to Cancer Research Senior Leadership Director Previous Directors NCI Organization Divisions, Offices & Centers ...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mann, Reinhold C.

This is the first formal progress report issued by the ORNL Life Sciences Division. It covers the period from February 1997 through December 1998, which has been critical in the formation of our new division. The legacy of 50 years of excellence in biological research at ORNL has been an important driver for everyone in the division to do their part so that this new research division can realize the potential it has to make seminal contributions to the life sciences for years to come. This reporting period is characterized by intense assessment and planning efforts. They included thorough scrutinymore » of our strengths and weaknesses, analyses of our situation with respect to comparative research organizations, and identification of major thrust areas leading to core research efforts that take advantage of our special facilities and expertise. Our goal is to develop significant research and development (R&D) programs in selected important areas to which we can make significant contributions by combining our distinctive expertise and resources in the biological sciences with those in the physical, engineering, and computational sciences. Significant facilities in mouse genomics, mass spectrometry, neutron science, bioanalytical technologies, and high performance computing are critical to the success of our programs. Research and development efforts in the division are organized in six sections. These cluster into two broad areas of R&D: systems biology and technology applications. The systems biology part of the division encompasses our core biological research programs. It includes the Mammalian Genetics and Development Section, the Biochemistry and Biophysics Section, and the Computational Biosciences Section. The technology applications part of the division encompasses the Assessment Technology Section, the Environmental Technology Section, and the Toxicology and Risk Analysis Section. These sections are the stewards of the division's core competencies. The common mission of the division is to advance science and technology to understand complex biological systems and their relationship with human health and the environment.« less

David L. Parkhurst as the recipient of the 2012 O.E. Meinzer Award of the Hydrogeology Division of the Geological Society of America

USGS Publications Warehouse

Glynn, Pierre D.

2012-01-01

Describes the impact of USGS scientist David Parkhurst's influential contributions to the fields of aqueous geochemistry and hydrogeology. Parkhurst is the recipient of the 2012 O.E. Meinzer award of the Geological Society of America's Hydrogeology Division.

Contribution of Resistance-Nodulation-Division Efflux Pump Operon smeU1-V-W-U2-X to Multidrug Resistance of Stenotrophomonas maltophilia ▿

PubMed Central

Chen, Chao-Hsien; Huang, Chiang-Ching; Chung, Tsao-Chuen; Hu, Rouh-Mei; Huang, Yi-Wei; Yang, Tsuey-Ching

2011-01-01

KJ09C, a multidrug-resistant mutant of Stenotrophomonas maltophilia KJ, was generated by in vitro selection with chloramphenicol. The multidrug-resistant phenotype of KJ09C was attributed to overexpression of a resistance nodulation division (RND)-type efflux system encoded by an operon consisting of five genes: smeU1, smeV, smeW, smeU2, and smeX. Proteins encoded by smeV, smeW, and smeX were similar to the membrane fusion protein, RND transporter, and outer membrane protein, respectively, of known RND-type systems. The proteins encoded by smeU1 and smeU2 were found to belong to the family of short-chain dehydrogenases/reductases. Mutant KJ09C exhibited increased resistance to chloramphenicol, quinolones, and tetracyclines and susceptibility to aminoglycosides; susceptibility to β-lactams and erythromycin was not affected. The expression of the smeU1-V-W-U2-X operon was regulated by the divergently transcribed LysR-type regulator gene smeRv. Overexpression of the SmeVWX pump contributed to the acquired resistance to chloramphenicol, quinolones, and tetracyclines. Inactivation of smeV and smeW completely abolished the activity of the SmeVWX pump, whereas inactivation of smeX alone decreased the activity of the SmeVWX pump. The enhanced aminoglycoside susceptibility observed in KJ09C resulted from SmeX overexpression. PMID:21930878

Solid State Division progress report for period ending March 31, 1997

DOE Office of Scientific and Technical Information (OSTI.GOV)

Green, P.H.; Hinton, L.W.

1997-12-01

This report covers research progress in the Solid State Division from April 1, 1995, through March 31, 1997. During this period, the division conducted a broad, interdisciplinary materials research program in support of Department of Energy science and technology missions. The report includes brief summaries of research activities in condensed matter theory, neutron scattering, synthesis and characterization of materials, ion beam and laser processing, and the structure of solids and surfaces. An addendum includes listings of division publications and professional activities.

Evolution of functional specialization and division of labor.

PubMed

Rueffler, Claus; Hermisson, Joachim; Wagner, Günter P

2012-02-07

Division of labor among functionally specialized modules occurs at all levels of biological organization in both animals and plants. Well-known examples include the evolution of specialized enzymes after gene duplication, the evolution of specialized cell types, limb diversification in arthropods, and the evolution of specialized colony members in many taxa of marine invertebrates and social insects. Here, we identify conditions favoring the evolution of division of labor by means of a general mathematical model. Our starting point is the assumption that modules contribute to two different biological tasks and that the potential of modules to contribute to these tasks is traded off. Our results are phrased in terms of properties of performance functions that map the phenotype of modules to measures of performance. We show that division of labor is favored by three factors: positional effects that predispose modules for one of the tasks, accelerating performance functions, and synergistic interactions between modules. If modules can be lost or damaged, selection for robustness can counteract selection for functional specialization. To illustrate our theory we apply it to the evolution of specialized enzymes coded by duplicated genes.

The activation of the G protein-coupled estrogen receptor (GPER) inhibits the proliferation of mouse melanoma K1735-M2 cells.

PubMed

Ribeiro, Mariana P C; Santos, Armanda E; Custódio, José B A

2017-11-01

The activation of the G protein-coupled estrogen receptor (GPER) by its specific agonist G-1 inhibits prostate cancer and 17β-estradiol-stimulated breast cancer cell proliferation. Tamoxifen (TAM), which also activates the GPER, decreases melanoma cell proliferation, but its action mechanism remains controversial. Here we investigated the expression and the effects of GPER activation by G-1, TAM and its key metabolite endoxifen (EDX) on melanoma cells. Mouse melanoma K1735-M2 cells expressed GPER and G-1 reduced cell biomass, and the number of viable cells, without increasing cell death. Rather, G-1 decreased cell division by blocking cell cycle progression in G2. Likewise, TAM and EDX exhibited an antiproliferative activity in melanoma cells due to decreased cell division. Both G-1 and the antiestrogens showed a trend to decrease the levels of phosphorylated ERK 1/2 after 1 h treatment, although only EDX, the most potent antiproliferative antiestrogen, induced significant effects. Importantly, the targeting of GPER with siRNA abolished the cytostatic activity of both G-1 and antiestrogens, suggesting that the antitumor actions of antiestrogens in melanoma cells involve GPER activation. Our results unveil a new target for melanoma therapy and identify GPER as a key mediator of antiestrogen antiproliferative effects, which may contribute to select the patients that benefit from an antiestrogen-containing regimen. Copyright © 2017 Elsevier B.V. All rights reserved.

75 FR 45153 - National Security Division; Agency Information Collection Activities: Proposed Collection...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-02

... DEPARTMENT OF JUSTICE [OMB Number 1124-0001] National Security Division; Agency Information..., 10th & Constitution Avenue, NW., National Security Division, Counterespionage Section/Registration Unit... Justice sponsoring the collection: Form Number: NSD- 1. National Security Division, U.S. Department of...

75 FR 45151 - National Security Division; Agency Information Collection Activities: Proposed Collection...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-02

... DEPARTMENT OF JUSTICE [OMB Number 1124-0006] National Security Division; Agency Information...), National Security Division (NSD), will be submitting the following information collection request to the..., 10th & Constitution Avenue, NW., National Security Division, Counterespionage Section/Registration Unit...

Photodamage: all signs lead to actinic keratosis and early squamous cell carcinoma.

PubMed

Wei, Jerry; Kok, Lai Fong; Byrne, Scott N; Halliday, Gary M

2015-01-01

Ultraviolet (UV) radiation is likely to drive the initiation and progression of skin cancer from actinic keratosis to squamous cell carcinoma. Signs of photodamage occur at multiple steps. UV radiation damages many cellular constituents, including lipids, proteins and DNA, all of which are likely to contribute to UV-induced skin cancer. Two biological events culminating from photodamage are mutations in the genes critical to the control of cell division, differentiation and invasion and immunosuppression. DNA photodamage, if unrepaired prior to cell division, can result in the incorporation of an incorrect nucleotide into newly synthesised DNA. Mutations in critical genes contribute to carcinogenesis. Photodamage to proteins such as those involved in DNA repair or proteins or lipids involved in cellular signalling can interfere with this repair process and contribute to mutagenesis. Mutations in key genes, including TP53, BRM, PTCH1, and HRAS, contribute to skin carcinogenesis. UV also damages immunity. Photodamage to DNA and signalling lipids as well as other molecular changes are detrimental to the key cells that regulate immunity. Photodamaged dendritic cells and altered responses by mast cells lead to the activation of T and B regulatory cells that suppress immunity to the protein products of UV-mutated genes. This stops the immune response from its protective function of destroying mutated cells, enabling the transformed cells to progress to skin cancer. UV appears to play a pivotal role at each of these steps, and therefore, signs of photodamage point to the development of skin cancer. © 2015 S. Karger AG, Basel.

Design, synthesis and antibacterial activity of cinnamaldehyde derivatives as inhibitors of the bacterial cell division protein FtsZ.

PubMed

Li, Xin; Sheng, Juzheng; Huang, Guihua; Ma, Ruixin; Yin, Fengxin; Song, Di; Zhao, Can; Ma, Shutao

2015-06-05

In an attempt to discover potential antibacterial agents against the increasing bacterial resistance, novel cinnamaldehyde derivatives as FtsZ inhibitors were designed, synthesized and evaluated for their antibacterial activity against nine significant pathogens using broth microdilution method, and their cell division inhibitory activity against four representative strains. In the in vitro antibacterial activity, the newly synthesized compounds generally displayed better efficacy against Staphylococcus aureus ATCC25923 than the others. In particular, compounds 3, 8 and 10 exerted superior or comparable activity to all the reference drugs. In the cell division inhibitory activity, all the compounds showed the same trend as their in vitro antibacterial activity, exhibiting better activity against S. aureus ATCC25923 than the other strains. Additionally, compounds 3, 6, 7 and 8 displayed potent cell division inhibitory activity with an MIC value of below 1 μg/mL, over 256-fold better than all the reference drugs. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

Cigar Smoking and Cancer

MedlinePlus

... About NCI NCI Overview History Contributing to Cancer Research Leadership Director's Page Deputy Director's Page Previous NCI Directors ... Overview & Mission History of NCI Contributing to Cancer Research Senior Leadership Director Deputy Director Previous Directors NCI Organization Divisions, ...

Drosophila Sulf1 is required for the termination of intestinal stem cell division during regeneration.

PubMed

Takemura, Masahiko; Nakato, Hiroshi

2017-01-15

Stem cell division is activated to trigger regeneration in response to tissue damage. The molecular mechanisms by which this stem cell mitotic activity is properly repressed at the end of regeneration are poorly understood. Here, we show that a specific modification of heparan sulfate is crucial for regulating Drosophila intestinal stem cell (ISC) division during normal midgut homeostasis and regeneration. Loss of the extracellular heparan sulfate endosulfatase Sulf1 resulted in increased ISC division during normal homeostasis, which was caused by upregulation of mitogenic signaling including the JAK-STAT, EGFR and Hedgehog pathways. Using a regeneration model, we found that ISCs failed to properly halt division at the termination stage in Sulf1 mutants, showing that Sulf1 is required for terminating ISC division at the end of regeneration. We propose that post-transcriptional regulation of mitogen signaling by heparan sulfate structural modifications provides a new regulatory step for precise temporal control of stem cell activity during regeneration. © 2017. Published by The Company of Biologists Ltd.

CDC-25.2, a C. elegans ortholog of cdc25, is essential for the progression of intestinal divisions.

PubMed

Lee, Yong-Uk; Son, Miseol; Kim, Jiyoung; Shim, Yhong-Hee; Kawasaki, Ichiro

2016-01-01

Intestinal divisions in Caenorhabditis elegans take place in 3 stages: (1) cell divisions during embryogenesis, (2) binucleations at the L1 stage, and (3) endoreduplications at the end of each larval stage. Here, we report that CDC-25.2, a C. elegans ortholog of Cdc25, is required for these specialized division cycles between the 16E cell stage and the onset of endoreduplication. Results of our genetic analyses suggest that CDC-25.2 regulates intestinal cell divisions and binucleations by counteracting WEE-1.3 and by activating the CDK-1/CYB-1 complex. CDC-25.2 activity is then repressed by LIN-23 E3 ubiquitin ligase before the onset of intestinal endoreduplication, and this repression is maintained by LIN-35, the C. elegans ortholog of Retinoblastoma (Rb). These findings indicate that timely regulation of CDC-25.2 activity is essential for the progression of specialized division cycles and development of the C. elegans intestine.

CDC-25.2, a C. elegans ortholog of cdc25, is essential for the progression of intestinal divisions

PubMed Central

Lee, Yong-Uk; Son, Miseol; Kim, Jiyoung; Shim, Yhong-Hee; Kawasaki, Ichiro

2016-01-01

ABSTRACT Intestinal divisions in Caenorhabditis elegans take place in 3 stages: (1) cell divisions during embryogenesis, (2) binucleations at the L1 stage, and (3) endoreduplications at the end of each larval stage. Here, we report that CDC-25.2, a C. elegans ortholog of Cdc25, is required for these specialized division cycles between the 16E cell stage and the onset of endoreduplication. Results of our genetic analyses suggest that CDC-25.2 regulates intestinal cell divisions and binucleations by counteracting WEE-1.3 and by activating the CDK-1/CYB-1 complex. CDC-25.2 activity is then repressed by LIN-23 E3 ubiquitin ligase before the onset of intestinal endoreduplication, and this repression is maintained by LIN-35, the C. elegans ortholog of Retinoblastoma (Rb). These findings indicate that timely regulation of CDC-25.2 activity is essential for the progression of specialized division cycles and development of the C. elegans intestine. PMID:27104746

Drosophila Sulf1 is required for the termination of intestinal stem cell division during regeneration

PubMed Central

2017-01-01

ABSTRACT Stem cell division is activated to trigger regeneration in response to tissue damage. The molecular mechanisms by which this stem cell mitotic activity is properly repressed at the end of regeneration are poorly understood. Here, we show that a specific modification of heparan sulfate is crucial for regulating Drosophila intestinal stem cell (ISC) division during normal midgut homeostasis and regeneration. Loss of the extracellular heparan sulfate endosulfatase Sulf1 resulted in increased ISC division during normal homeostasis, which was caused by upregulation of mitogenic signaling including the JAK-STAT, EGFR and Hedgehog pathways. Using a regeneration model, we found that ISCs failed to properly halt division at the termination stage in Sulf1 mutants, showing that Sulf1 is required for terminating ISC division at the end of regeneration. We propose that post-transcriptional regulation of mitogen signaling by heparan sulfate structural modifications provides a new regulatory step for precise temporal control of stem cell activity during regeneration. PMID:27888216

75 FR 45152 - National Security Division: Agency Information Collection Activities: Proposed Collection...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-02

... DEPARTMENT OF JUSTICE [OMB Number 1124-0004] National Security Division: Agency Information...), National Security Division (NSD), will be submitting the following information collection request to the... write to U.S. Department of Justice, 10th & Constitution Avenue, NW., National Security Division...

Waste minimization/pollution prevention study of high-priority waste streams

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ogle, R.B.

1994-03-01

Although waste minimization has been practiced by the Metals and Ceramics (M&C) Division in the past, the effort has not been uniform or formalized. To establish the groundwork for continuous improvement, the Division Director initiated a more formalized waste minimization and pollution prevention program. Formalization of the division`s pollution prevention efforts in fiscal year (FY) 1993 was initiated by a more concerted effort to determine the status of waste generation from division activities. The goal for this effort was to reduce or minimize the wastes identified as having the greatest impact on human health, the environment, and costs. Two broadmore » categories of division wastes were identified as solid/liquid wastes and those relating to energy use (primarily electricity and steam). This report presents information on the nonradioactive solid and liquid wastes generated by division activities. More specifically, the information presented was generated by teams of M&C staff members empowered by the Division Director to study specific waste streams.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

This report contains the following information from the Instrumentation and Controls Division of Oak Ridge National Laboratory: supplementary activities; seminars; publications and presentations; scientific and professional activities, achievements, and awards; and division organization charts.

Promoting youth physical activity in rural southern communities: practitioner perceptions of environmental opportunities and barriers.

PubMed

Edwards, Michael B; Theriault, Daniel S; Shores, Kindal A; Melton, Karen M

2014-01-01

Research on youth physical activity has focused on urban areas. Rural adolescents are more likely to be physically inactive than urban youth, contributing to higher risk of obesity and chronic diseases. Study objectives were to: (1) identify perceived opportunities and barriers to youth physical activity within a rural area and (2) identify rural community characteristics that facilitate or inhibit efforts to promote youth physical activity. Thirty in-depth interviews were conducted with expert informants in 2 rural southern US counties. Interviewees were recruited from diverse positions across multiple sectors based on their expert knowledge of community policies and programs for youth physical activity. Informants saw ball fields, natural amenities, and school sports as primary resources for youth physical activity, but they were divided on whether opportunities were abundant or scarce. Physical distance, social isolation, lack of community offerings, and transportation were identified as key barriers. Local social networks facilitated political action and volunteer recruitment to support programs. However, communities often lacked human capital to sustain initiatives. Racial divisions influenced perceptions of opportunities. Despite divisions, there were also examples of pooling resources to create and sustain physical activity opportunities. Developing partnerships and leveraging local resources may be essential to overcoming barriers for physical activity promotion in rural areas. Involvement of church leaders, school officials, health care workers, and cooperative extension is likely needed to establish and sustain youth rural physical activity programs. Allocating resources to existing community personnel and volunteers for continuing education may be valuable. © 2014 National Rural Health Association.

Substantial contribution of extrinsic risk factors to cancer development

PubMed Central

Wu, Song; Powers, Scott; Zhu, Wei; Hannun, Yusuf A

2015-01-01

Summary Recent research has highlighted a strong correlation between tissue-specific cancer risk and the lifetime number of tissue-specific stem cell divisions. Whether such correlation implies a high unavoidable intrinsic cancer risk has become a key public health debate with dissemination of the ‘bad luck’ hypothesis. Here we provide evidence that intrinsic risk factors contribute only modestly (<10~30%) to cancer development. First, we demonstrate that the correlation between stem-cell division and cancer risk does not distinguish between the effects of intrinsic and extrinsic factors. Next, we show that intrinsic risk is better estimated by the lower bound risk controlling for total stem cell divisions. Finally, we show that the rates of endogenous mutation accumulation by intrinsic processes are not sufficient to account for the observed cancer risks. Collectively, we conclude that cancer risk is heavily influenced by extrinsic factors. These results carry immense consequences for strategizing cancer prevention, research, and public health. PMID:26675728

AMPKα1 controls hepatocyte proliferation independently of energy balance by regulating Cyclin A2 expression.

PubMed

Merlen, Grégory; Gentric, Géraldine; Celton-Morizur, Séverine; Foretz, Marc; Guidotti, Jacques-Emmanuel; Fauveau, Véronique; Leclerc, Jocelyne; Viollet, Benoit; Desdouets, Chantal

2014-01-01

AMP-activated protein kinase (AMPK) is an evolutionarily conserved sensor of cellular energy status that contributes to restoration of energy homeostasis by slowing down ATP-consuming pathways and activating ATP-producing pathways. Unexpectedly, in different systems, AMPK is also required for proper cell division. In the current study, we evaluated the potential effect of the AMPK catalytic subunit, AMPKα1, on hepatocyte proliferation. Hepatocyte proliferation was determined in AMPKα1 knockout and wild-type mice in vivo after two thirds partial hepatectomy, and in vitro in primary hepatocyte cultures. The activities of metabolic and cell cycle-related signaling pathways were measured. After partial hepatectomy, hepatocytes proliferated rapidly, correlating with increased AMPK phosphorylation. Deletion of AMPKα1 delayed liver regeneration by impacting on G1/S transition phase. The proliferative defect of AMPKα1-deficient hepatocytes was cell autonomous, and independent of energy balance. The priming phase, lipid droplet accumulation, protein anabolic responses and growth factor activation after partial hepatectomy occurred normally in the absence of AMPKα1 activity. By contrast, mRNA and protein expression of cyclin A2, a key driver of S phase progression, were compromised in the absence of AMPK activity. Importantly, AMPKα1 controlled cyclin A2 transcription mainly through the ATF/CREB element. Our study highlights a novel role for AMPKα1 as a positive regulator of hepatocyte division occurring independently of energy balance. Copyright © 2013 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

The Gender Division of Labor and the Reproduction of Female Disadvantage: Toward an Integrated Theory.

ERIC Educational Resources Information Center

Chafetz, Janet Saltzman

1988-01-01

Presents a theory of mechanisms sustaining and reproducing systems of gender stratification, central amongst which is gender division of labor, within both the family and the wider society. Asserts men create dominant social functions which contribute further to gender stratification. Maintains women then choose that which they would otherwise be…

Feminist Knowledge Claims, Local Knowledge, and Gender Divisions of Agricultural Labor: Constructing a Successor Science.

ERIC Educational Resources Information Center

Feldman, Shelley; Welsh, Rick

1995-01-01

Issues raised by feminist epistemic critiques of social science are used to examine local (farmer-based) knowledge of agriculture and its contribution to analyses of agricultural sustainability. Focuses on the on-farm gender division of labor as critical in constituting the family farm, and elaborates how different experiences of men and women…

Informal Care and the Division of End-of-Life Transfers

ERIC Educational Resources Information Center

Brown, Meta

2006-01-01

Unmarried parents in the AHEAD study derive the majority of their long-term care hours from their children, and child caregivers are generally unpaid. This paper examines the extent to which the division of end-of-life transfers compensates caregiving children. In a model of siblings' altruistic contribution of care to a shared parent, the…

Proceedings of the Annual Meeting of the Association for Education in Journalism and Mass Communication (85th, Miami, Florida, August 5-8, 2002). Advertising Division.

ERIC Educational Resources Information Center

2002

The Advertising Division of the proceedings contains the following 20 papers: "Business and Communication Programs' Contribution in Advertising Education and Research: A Comparison" (Tien-tsung Lee); "Attributions of Advertising Influence Via Third-Person Perceptions: A Review and Synthesis" (Don Umphrey); "Advertising…

75 FR 45166 - Jeld-Wen, Inc., Hawkins Window Division, Including On-Site Leased Workers of Nicolet Staffing...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-02

... Window Division, Including On-Site Leased Workers of Nicolet Staffing, Hawkins, WI; Notice of Negative... imports of wood- and aluminum- clad windows and patio doors did not contribute to worker group separations... of wood- and aluminum-clad windows and patio doors during 2007, 2008, January through April 2008, and...

Role of asymmetric cell division in lifespan control in Saccharomyces cerevisiae

PubMed Central

Higuchi-Sanabria, Ryo; Pernice, Wolfgang M A; Vevea, Jason D; Alessi Wolken, Dana M; Boldogh, Istvan R; Pon, Liza A

2014-01-01

Aging determinants are asymmetrically distributed during cell division in S. cerevisiae, which leads to production of an immaculate, age-free daughter cell. During this process, damaged components are sequestered and retained in the mother cell, and higher functioning organelles and rejuvenating factors are transported to and/or enriched in the bud. Here, we will describe the key quality control mechanisms in budding yeast that contribute to asymmetric cell division of aging determinants including mitochondria, endoplasmic reticulum (ER), vacuoles, extrachromosomal rDNA circles (ERCs), and protein aggregates. PMID:25263578

Tumor suppressor Lzap regulates cell cycle progression, doming and zebrafish epiboly

PubMed Central

Liu, Dan; Wang, Wen-Der; Melville, David B.; Cha, Yong I.; Yin, Zhirong; Issaeva, Natalia; Knapik, Ela W.; Yarbrough, Wendell G.

2012-01-01

Initial stages of embryonic development rely on rapid, synchronized cell divisions of the fertilized egg followed by a set of morphogenetic movements collectively called epiboly and gastrulation. Lzap is a putative tumor suppressor whose expression is lost in 30% of head and neck squamous cell carcinomas. Lzap activities include regulation of cell cycle progression and response to therapeutic agents. Here we explore developmental roles of the lzap gene during zebrafish morphogenesis. Lzap is highly conserved among vertebrates and is maternally deposited. Expression is initially ubiquitous during gastrulation, and later becomes more prominent in the pharyngeal arches, digestive tract and brain. Antisense morpholino-mediated depletion of Lzap resulted in delayed cell divisions and apoptosis during blastomere formation, resulting in fewer, larger cells. Cell cycle analysis suggested that Lzap loss in early embryonic cells resulted in a G2/M arrest. Furthermore, the Lzap-deficient embryos failed to initiate epiboly – the earliest morphogenetic movement in animal development – which has been shown to be dependent on cell adhesion and migration of epithelial sheets. Our results strongly implicate Lzap in regulation of cell cycle progression, adhesion and migratory activity of epithelial cell sheets during early development. These functions provide further insight into Lzap activity that may contribute not only to development, but also to tumor formation. PMID:21523853

The EGU Seismology Division Early Career Scientist Representative team and its initiatives

NASA Astrophysics Data System (ADS)

Parisi, Laura; Ermert, Laura; Gualtieri, Lucia; Spieker, Kathrin; Van Noten, Koen; Agius, Matthew R.; Mai, P. Martin

2017-04-01

Since 2014, the Seismology Division (SM) of the European Geosciences Union (EGU) has its Early Career Scientist (ECS) representative to reach out to its numerous 'younger' members. In April 2016, a new team of representatives joined the Division. We are a vivid team of early career scientists, representing both (either) PhD students and post-doctoral researchers working in different seismological disciplines and different countries. The initiatives of the SM ECS-rep team have various aims: (1) to motivate the ECSs to get involved in activities and initiatives of the EGU and the Seismology Division, (2) to promote the research of ECSs, (3) to discuss issues concerning seismologists during this particular stage of their career, (4) to share ideas on how to promote equality between scientists and (5) to improve on the public dissemination of scientific knowledge. In an effort to reach out to experienced and ECS seismologists more effectively and to continuously encourage to voice their ideas by contributing and following our initiatives, a blog and social media pages dedicated to seismology and earthquake trivia are run by the team. Weekly posts are published on the blog and shared on the social media regarding scientific and social aspects of seismology. One of the major contributions recently introduced to the blog is the "Paper of the Month" series where experienced seismologists write about recent or classical - must read - seismology articles. We also aim to organise and promote social and scientific events. During the EGU General Assembly 2016 a social event was held in Vienna allowing ECS to network with peers in an informal environment. Given the success of this event, a similar event will be organized during the General Assembly 2017. Also, similar to previous years, a short course on basic seismology for non seismologists will be requested and offered to all ECSs attending the General Assembly. Finally, a workshop dedicated entirely to ECSs seismologists will take place in summer 2017. This event, which is co-funded by EGU, will focus on enhancing ECS skills and granting strategies to progress their careers. We present the work that has been carried out since the election of the new team, including details of what has been achieved so far, and what our goals are to achieve in the next year. USEFUL LINKS Blog http://blogs.egu.eu/divisions/sm/ Facebook page https://www.facebook.com/EGUSeismologyDivision/ Twitter account https://twitter.com/EGU_Seismo

Metals and Ceramics Division progress report for period ending December 31, 1992

DOE Office of Scientific and Technical Information (OSTI.GOV)

Craig, D.F.; Weir, J.R. Jr.

1993-04-01

This report provides a brief overview of the activities and accomplishments of the division, whose purpose is to provide technical support, primarily in the area of high-temperature materials, for the various technologies being developed by US DOE. Activities range from basic research to industrial research and technology transfer. The division (and the report) is divided into the following: Engineering materials, high-temperature materials, materials science, ceramics, nuclear fuel materials, program activities, collaborative research facilities and technology transfer, and educational programs.

Calculations of binding affinity between C8-substituted GTP analogs and the bacterial cell-division protein FtsZ

PubMed Central

Hritz, Jozef; Läppchen, Tilman

2010-01-01

The FtsZ protein is a self-polymerizing GTPase that plays a central role in bacterial cell division. Several C8-substituted GTP analogs are known to inhibit the polymerization of FtsZ by competing for the same binding site as its endogenous activating ligand GTP. Free energy calculations of the relative binding affinities to FtsZ for a set of five C8-substituted GTP analogs were performed. The calculated values agree well with the available experimental data, and the main contribution to the free energy differences is determined to be the conformational restriction of the ligands. The dihedral angle distributions around the glycosidic bond of these compounds in water are known to vary considerably depending on the physicochemical properties of the substituent at C8. However, within the FtsZ protein, this substitution has a negligible influence on the dihedral angle distributions, which fall within the narrow range of −140° to −90° for all investigated compounds. The corresponding ensemble average of the coupling constants 3J(C4,H1′) is calculated to be 2.95 ± 0.1 Hz. The contribution of the conformational selection of the GTP analogs upon binding was quantified from the corresponding populations. The obtained restraining free energy values follow the same trend as the relative binding affinities to FtsZ, indicating their dominant contribution. PMID:20559630

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

The primary purpose of this report is to provide an archival record of the activities of the Engineering Physics and Mathematics Division during the period September 1, 1989 through March 31, 1991. Earlier reports in this series are identified on the previous pages, along with the progress reports describing ORNL's research on the mathematical sciences prior to 1984 when those activities moved into the division. As in previous reports, our research is described through abstracts of journal articles, technical reports, and presentations. Summary lists of publications and presentations, staff additions and departures, scientific and professional activities of division staff, andmore » technical conferences organized and sponsored by the division are included as appendices. The report is organized following the division of our research among four sections and information centers. These research areas are: Mathematical Sciences; Nuclear Data Measurement and Evaluations; Intelligent Systems; Nuclear Analysis and Shielding; and Engineering Physics Information Center.« less

Fission yeast APC/C activators Slp1 and Fzr1 sequentially trigger two consecutive nuclear divisions during meiosis.

PubMed

Chikashige, Yuji; Yamane, Miho; Okamasa, Kasumi; Osakada, Hiroko; Tsutsumi, Chihiro; Nagahama, Yuki; Fukuta, Noriko; Haraguchi, Tokuko; Hiraoka, Yasushi

2017-04-01

In meiosis, two rounds of nuclear division occur consecutively without DNA replication between the divisions. We isolated a fission yeast mutant in which the nucleus divides only once to generate two spores, as opposed to four, in meiosis. In this mutant, we found that the initiation codon of the slp1 + gene is converted to ATA, producing a reduced amount of Slp1. As a member of the Fizzy family of anaphase-promoting complex/cyclosome (APC/C) activators, Slp1 is essential for vegetative growth; however, the mutant allele shows a phenotype only in meiosis. Slp1 insufficiency delays degradation of maturation-promoting factor at the first meiotic division, and another APC/C activator, Fzr1, which acts late in meiosis, terminates meiosis immediately after the delayed first division to produce two viable spores. © 2017 Federation of European Biochemical Societies.

77 FR 12600 - National Cancer Institute; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-01

... Extramural Activities, National Cancer Institute, NIH, 6116 Executive Boulevard, Room 8055B, Bethesda, MD..., Division of Extramural Activities, National Cancer Institute, NIH, 6116 Executive Blvd., Room 8101... Review Officer, Special Review and Logistics Branch, Division of Extramural Activities, National Cancer...

33 CFR 211.7 - Rights which may be granted by Division and District Engineers.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Division and District Engineers. 211.7 Section 211.7 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE REAL ESTATE ACTIVITIES OF THE CORPS OF ENGINEERS IN CONNECTION... be granted by Division and District Engineers. (a) Authority of Division and District Engineers...

Cell division and turgor mediate enhanced plant growth in Arabidopsis plants treated with the bacterial signalling molecule lumichrome.

PubMed

Pholo, Motlalepula; Coetzee, Beatrix; Maree, Hans J; Young, Philip R; Lloyd, James R; Kossmann, Jens; Hills, Paul N

2018-05-17

Transcriptomic analysis indicates that the bacterial signalling molecule lumichrome enhances plant growth through a combination of enhanced cell division and cell enlargement, and possibly enhances photosynthesis. Lumichrome (7,8 dimethylalloxazine), a novel multitrophic signal molecule produced by Sinorhizobium meliloti bacteria, has previously been shown to elicit growth promotion in different plant species (Phillips et al. in Proc Natl Acad Sci USA 96:12275-12280, https://doi.org/10.1073/pnas.96.22.12275 , 1999). However, the molecular mechanisms that underlie this plant growth promotion remain obscure. Global transcript profiling using RNA-seq suggests that lumichrome enhances growth by inducing genes impacting on turgor driven growth and mitotic cell cycle that ensures the integration of cell division and expansion of developing leaves. The abundance of XTH9 and XPA4 transcripts was attributed to improved mediation of cell-wall loosening to allow turgor-driven cell enlargement. Mitotic CYCD3.3, CYCA1.1, SP1L3, RSW7 and PDF1 transcripts were increased in lumichrome-treated Arabidopsis thaliana plants, suggesting enhanced growth was underpinned by increased cell differentiation and expansion with a consequential increase in biomass. Synergistic ethylene-auxin cross-talk was also observed through reciprocal over-expression of ACO1 and SAUR54, in which ethylene activates the auxin signalling pathway and regulates Arabidopsis growth by both stimulating auxin biosynthesis and modulating the auxin transport machinery to the leaves. Decreased transcription of jasmonate biosynthesis and responsive-related transcripts (LOX2; LOX3; LOX6; JAL34; JR1) might contribute towards suppression of the negative effects of methyl jasmonate (MeJa) such as chlorophyll loss and decreases in RuBisCO and photosynthesis. This work contributes towards a deeper understanding of how lumichrome enhances plant growth and development.

Examining Factors That Influence Donor Motivation among Former Student-Athletes and NCAA DI Classification

ERIC Educational Resources Information Center

Burchette, Brett M.

2013-01-01

The purpose of this study was to identify motivational factors that contribute to the philanthropic decision making of the former NCAA Division I student-athlete. A 47-item survey instrument was modified from a prior study and distributed electronically to 8,461 male and female former student-athletes at three participating NCAA Division I…

Proceedings of the frst joint american chemical society agricultural and food chemistry division – american chemical society international chemical sciences chapter in Thailand symposium on agricultural and food chemistry

USDA-ARS?s Scientific Manuscript database

This Proceedings is a compilation of papers from contributed oral and poster presentations presented at the first joint symposium organized by the American Chemical Society Agricultural and Food Chemistry Division and the American Chemical Society International Chemical Sciences Chapter in Thailand ...

Two Outstanding Investigator Awards Go to Division of Cancer Prevention Grantees | Division of Cancer Prevention

Cancer.gov

NCI's Outstanding Investigator Award supports accomplished leaders in cancer research, who are providing significant contributions toward understanding cancer and developing applications that may lead to a breakthrough in biomedical, behavioral, or clinical cancer research. The Award provides up to $600,000 in direct costs per year for 7 years, allowing substantial time for

Contextual factors affecting task distribution in two participatory ergonomic interventions: a qualitative study.

PubMed

Dixon, Shane Michael; Theberge, Nancy

2011-11-01

This article provides an analysis of the evolution of the division of labour in participatory ergonomics (PE) programmes in two worksites. The analysis is based on interviews and field observations in the worksites. In both settings there was meaningful participation by both worker and management members of ergonomic change teams (ECTs) in the hazard assessment and solution identification stages, but as the teams moved to the implementation stage, worker representatives were marginalised and the participatory nature of the programmes was severely curtailed. The removal of workers from the process was the outcome of the interplay among the type of activities pursued in the implementation stage, the skills and knowledge required to carry out those activities, and workers' limited influence in the organisational hierarchies. Findings highlight the salience of the social context in which participatory programmes are located and the importance of examining participatory programmes as they evolve over time. STATEMENT OF RELEVANCE: This article contributes to a growing literature on the process and implementation of PE programmes. The article's focus on social and organisational factors that affect the division of labour and attention to the evolution of involvement over time extend current understandings of participation in ergonomics programmes.

The Ampere and Electrical Standards

PubMed Central

Elmquist, Randolph E.; Cage, Marvin E.; Tang, Yi-hua; Jeffery, Anne-Marie; Kinard, Joseph R.; Dziuba, Ronald F.; Oldham, Nile M.; Williams, Edwin R.

2001-01-01

This paper describes some of the major contributions to metrology and physics made by the NIST Electricity Division, which has existed since 1901. It was one of the six original divisions of the National Bureau of Standards. The Electricity Division provides dc and low-frequency calibrations for industrial, scientific, and research organizations, and conducts research on topics related to electrical metrology and fundamental constants. The early work of the Electricity Division staff included the development of precision standards, such as Rosa and Thomas standard resistors and the ac-dc thermal converter. Research contributions helped define the early international system of measurement units and bring about the transition to absolute units based on fundamental principles and physical and dimensional measurements. NIST research has helped to develop and refine electrical standards using the quantum Hall effect and the Josephson effect, which are both based on quantum physics. Four projects covering a number of voltage and impedance measurements are described in detail. Several other areas of current research at NIST are described, including the use of the Internet for international compatibility in metrology, determination of the fine-structure and Planck constants, and construction of the electronic kilogram. PMID:27500018

Improving Student Engagement in a Lower-Division Botany Course

ERIC Educational Resources Information Center

Goldberg, Nisse A.; Ingram, Kathleen W.

2011-01-01

Active-learning techniques have been advocated as a means to promote student engagement in lower-division biology courses. In this case study, mini-lectures in combination with active-learning activities were evaluated as strategies to promote a culture of learning and participation in a required botany course. These activities were designed to…

Environmental Sciences Division annual progress report for period ending September 30, 1994

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1994-12-31

This progress report summarizes the research and development activities conducted in the Environmental Sciences Division (ESD) of Oak Ridge National Laboratory during fiscal year (FY) 1994, which extended from October 1, 1993, through September 30, 1994. The report is structured to provide descriptions of current activities and accomplishments in each of the division`s major organizational units. Following the sections describing the organizational units are sections highlighting ESD Scientific, Technical, and Administrative Achievement awards and listing information necessary to covey the scope of the work in the division. An organizational chart of staff and long-term guests who wee in ESD atmore » the end of FY 1994 is located in the final section of the report.« less

Arabidopsis  SABRE and CLASP interact to stabilize cell division plane orientation and planar polarity.

PubMed

Pietra, Stefano; Gustavsson, Anna; Kiefer, Christian; Kalmbach, Lothar; Hörstedt, Per; Ikeda, Yoshihisa; Stepanova, Anna N; Alonso, Jose M; Grebe, Markus

2013-01-01

The orientation of cell division and the coordination of cell polarity within the plane of the tissue layer (planar polarity) contribute to shape diverse multicellular organisms. The root of Arabidopsis thaliana displays regularly oriented cell divisions, cell elongation and planar polarity providing a plant model system to study these processes. Here we report that the SABRE protein, which shares similarity with proteins of unknown function throughout eukaryotes, has important roles in orienting cell division and planar polarity. SABRE localizes at the plasma membrane, endomembranes, mitotic spindle and cell plate. SABRE stabilizes the orientation of CLASP-labelled preprophase band microtubules predicting the cell division plane, and of cortical microtubules driving cell elongation. During planar polarity establishment, sabre is epistatic to clasp at directing polar membrane domains of Rho-of-plant GTPases. Our findings mechanistically link SABRE to CLASP-dependent microtubule organization, shedding new light on the function of SABRE-related proteins in eukaryotes.

75 FR 9432 - Civil Rights Division, Disability Rights Section; Agency Information Collection Activities Under...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-02

... Division, by calling (800) 514-0301 (Voice) or (800) 514- 0383 (TTY) (the Division's ADA Information Line... to evaluate their current services, policies, and practices for compliance with the ADA. Under...

Competitive Advantage in Intercollegiate Athletics: Role of Intangible Resources.

PubMed

Won, Doyeon; Chelladurai, Packianathan

2016-01-01

The present research explored the dynamics of competitive advantages in intercollegiate athletics by investigating the contribution of intangible resources (i.e., athletic and academic reputations) on the generation of more tangible resources (i.e., human and financial resources), which in turn influence the athletic performance (i.e., winning record) and academic performance (i.e., graduation rates), and gender equity. The research was based entirely on archival data of 324 NCAA Division I member institutions. The results of the SEM supported the study's basic arguments that tangible resources are the sources of competitive advantages in Division I intercollegiate athletics, and that intangible resources contribute to the generation of tangible resources.

ABI domain containing proteins contribute to surface protein display and cell division in Staphylococcus aureus

PubMed Central

Frankel, Matthew B.; Wojcik, Brandon; DeDent, Andrea C.; Missiakas, Dominique M.; Schneewind, Olaf

2012-01-01

Summary The human pathogen Staphyloccocus aureus requires cell wall anchored surface proteins to cause disease. During cell division, surface proteins with YSIRK signal peptides are secreted into the cross wall, a layer of newly synthesized peptidoglycan between separating daughter cells. The molecular determinants for the trafficking of surface proteins are, however, still unknown. We screened mutants with non-redundant transposon insertions by fluorescence-activated cell sorting for reduced deposition of protein A (SpA) into the staphylococcal envelope. Three mutants, each of which harbored transposon insertions in genes for transmembrane proteins, displayed greatly reduced envelope abundance of SpA and surface proteins with YSIRK signal peptides. Characterization of the corresponding mutations identified three transmembrane proteins with abortive infectivity (ABI) domains, elements first described in lactococci for their role in phage exclusion. Mutations in genes for ABI domain proteins, designated spdA, spdB and spdC (surface protein display), diminish the expression of surface proteins with YSIRK signal peptides, but not of precursor proteins with conventional signal peptides. spdA, spdB and spdC mutants display an increase in the thickness of cross walls and in the relative abundance of staphylococci with cross walls, suggesting that spd mutations may represent a possible link between staphylococcal cell division and protein secretion. PMID:20923422

ABI domain-containing proteins contribute to surface protein display and cell division in Staphylococcus aureus.

PubMed

Frankel, Matthew B; Wojcik, Brandon M; DeDent, Andrea C; Missiakas, Dominique M; Schneewind, Olaf

2010-10-01

The human pathogen Staphylococcus aureus requires cell wall anchored surface proteins to cause disease. During cell division, surface proteins with YSIRK signal peptides are secreted into the cross-wall, a layer of newly synthesized peptidoglycan between separating daughter cells. The molecular determinants for the trafficking of surface proteins are, however, still unknown. We screened mutants with non-redundant transposon insertions by fluorescence-activated cell sorting for reduced deposition of protein A (SpA) into the staphylococcal envelope. Three mutants, each of which harboured transposon insertions in genes for transmembrane proteins, displayed greatly reduced envelope abundance of SpA and surface proteins with YSIRK signal peptides. Characterization of the corresponding mutations identified three transmembrane proteins with abortive infectivity (ABI) domains, elements first described in lactococci for their role in phage exclusion. Mutations in genes for ABI domain proteins, designated spdA, spdB and spdC (surface protein display), diminish the expression of surface proteins with YSIRK signal peptides, but not of precursor proteins with conventional signal peptides. spdA, spdB and spdC mutants display an increase in the thickness of cross-walls and in the relative abundance of staphylococci with cross-walls, suggesting that spd mutations may represent a possible link between staphylococcal cell division and protein secretion. © 2010 Blackwell Publishing Ltd.

15 years in promoting the use of isotopic and nuclear technique for combating land degradation and soil erosion: the contribution of the Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture

NASA Astrophysics Data System (ADS)

Mabit, Lionel; Toloza, Arsenio; Heng, Lee

2017-04-01

The world population will exceed 9 billion by the year 2050 and food production will need to be approximately doubled to meet this crucial demand. Most of this increase will occur in developing countries, where the majority of the population depends on agriculture and their land for their livelihoods. Reports from the Intergovernmental Panel on Climate Change (IPCC) predicted negative impact of climate change, threatening global food security. In addition, the intensification of agricultural activities has increased pressure on land and water resources, resulting in different forms of soil degradation, of which soil erosion and associated sedimentation are worsening. Worldwide economic costs of agricultural soil loss and associated sedimentation downstream have been estimated at US 400 billion per year. As a result of climate change, world average soil erosion is expected to further increase significantly. Adapting to climate change requires agricultural soil and water management practices that make agricultural production systems resilient to drought, floods and land degradation, to enhance the conservation of the natural resource base for sustainable upland farming. These current concerns with ensuring sustainable use and management of agroecosystems create an urgent need for reliable quantitative data on the extent and magnitude of soil resource degradation over several spatial and time scales to formulate sound policies and management measures. Integrated isotopic approaches can help in targeting adapted and effective soil-water conservation measures to control soil degradation and therefore contribute to positive feedback mechanisms to mitigate climate change impact on soil and water resources. Set up 60 years ago as the world's centre for cooperation in the nuclear field, the International Atomic Energy Agency (IAEA) promotes the safe, secure and peaceful use of nuclear technologies. Since the end of the 1990s, the Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture has developed research and development activities and capacity building to combat soil degradation (especially soil erosion) and to foster climate smart agriculture. More than 70 FAO/IAEA Member States have benefitted from the technical support and guidance in using fallout radionuclides (FRNs) and Compound-Specific Stable Isotope (CSSI) techniques to trace soil movement and assess soil erosion at different spatial and temporal scales, and to evaluate the effectiveness of soil conservation strategies to ensure sustainable land management. This contribution summarizes the historical background and the latest innovative activities conducted by the Joint FAO/IAEA Division, as well as the main advantages and complementarity of stable and radioisotopic tracers to conventional techniques when investigating land degradation. As examples of the significant role played by the Joint FAO/IAEA Division, two major outcomes achieved in Africa (i.e. Madagascar and Morocco) through the use of isotopic and nuclear techniques will be elaborated. The authors will also report on a new 5-year Co-ordinated Research Project (CRP) funded by the IAEA on "Nuclear Techniques for a Better Understanding of the Impact of Climate Change on Soil Erosion in Upland Agro-ecosystems" which involves key research institutions from 12 participating countries.

NASA University Program Management Information System

NASA Technical Reports Server (NTRS)

Gans, Gary

1997-01-01

As basic policy, NASA believes that colleges and universities should be encouraged to participate in the nation's space and aeronautics program to the maximum extent practicable. Indeed, universities are considered as partners with government and industry in the nation's aerospace program. NASA's objective is to have them bring their scientific, engineering, and social research competence to bear on aerospace problems and on the broader social, economic, and international implications of NASA's technical and scientific programs. It is expected that, in so doing, universities will strengthen both their research and their educational capabilities to contribute more effectively to the national well-being. NASA field codes and certain Headquarters program offices provide funds for those activities in universities which contribute to the mission needs of that particular NASA element. Although NASA has no predetermined amount of money to devote to university activities, the effort funded each year is substantial. This annual report is one means of documenting the NASA-university relationship, frequently denoted, collectively, as NASA's University Program. This report is consistent with agency accounting records, as the data is obtained from NASA's Financial and Contractual Status (FACS) System, operated by the Financial Management Division and the Procurement Office. However, in accordance with interagency agreements, the orientation differs from that required for financial or procurement purposes. Any apparent discrepancies between this report and other NASA procurement or financial reports stem from the selection criteria for the data. This report was prepared by the Education Division/FE, Office of Human Resources and Education, using a management information system which was modernized during FY 1993.

NASA University Program Management Information System

NASA Technical Reports Server (NTRS)

2000-01-01

As basic policy, NASA believes that colleges and universities should be encouraged to participate in the nation's space and aeronautics program to the maximum extent practicable. Indeed, universities are considered as partners with government and industry in the nation's aerospace program. NASA:s objective is to have them bring their scientific, engineering, and social research competence to bear on aerospace problems and on the broader social, economic, and international implications of NASA's technical and scientific programs. It is expected that, in so doing, universities will strengthen both their research and their educational capabilities to contribute more effectively to the national well-being. NASA field codes and certain Headquarters program offices provide funds for those activities in universities which contribute to the mission needs of that particular NASA element. Although NASA has no predetermined amount of money to devote to university activities, the effort funded each year is substantial. This annual report is one means of documenting the NASA-university relationship, frequently denoted, collectively, as NASA's University Program. This report is consistent with agency accounting records, as the data is obtained from NASA:s Financial and Contractual Status (FACS) System, operated by the Financial Management Division and the Procurement Office. However, in accordance with interagency agreements, the orientation differs from that required for financial or procurement purposes. Any apparent discrepancies between this report and other NASA procurement or financial reports stem from the selection criteria for the data.* This report was prepared by the Education Division/FE, Office of Human Resources and Education, using a management information system which was modernized during FY 1993.

Nonmedially assembled F-actin cables incorporate into the actomyosin ring in fission yeast

PubMed Central

Huang, Junqi; Huang, Yinyi; Yu, Haochen; Subramanian, Dhivya; Padmanabhan, Anup; Thadani, Rahul; Tao, Yaqiong; Tang, Xie; Wedlich-Soldner, Roland

2012-01-01

In many eukaryotes, cytokinesis requires the assembly and constriction of an actomyosin-based contractile ring. Despite the central role of this ring in cytokinesis, the mechanism of F-actin assembly and accumulation in the ring is not fully understood. In this paper, we investigate the mechanism of F-actin assembly during cytokinesis in Schizosaccharomyces pombe using lifeact as a probe to monitor actin dynamics. Previous work has shown that F-actin in the actomyosin ring is assembled de novo at the division site. Surprisingly, we find that a significant fraction of F-actin in the ring was recruited from formin-Cdc12p nucleated long actin cables that were generated at multiple nonmedial locations and incorporated into the ring by a combination of myosin II and myosin V activities. Our results, together with findings in animal cells, suggest that de novo F-actin assembly at the division site and directed transport of F-actin cables assembled elsewhere can contribute to ring assembly. PMID:23185032

Integrin trafficking regulated by Rab21 is necessary for cytokinesis.

PubMed

Pellinen, Teijo; Tuomi, Saara; Arjonen, Antti; Wolf, Maija; Edgren, Henrik; Meyer, Hannelore; Grosse, Robert; Kitzing, Thomas; Rantala, Juha K; Kallioniemi, Olli; Fässler, Reinhard; Kallio, Marko; Ivaska, Johanna

2008-09-01

Adherent cells undergo remarkable changes in shape during cell division. However, the functional interplay between cell adhesion turnover and the mitotic machinery is poorly understood. The endo/exocytic trafficking of integrins is regulated by the small GTPase Rab21, which associates with several integrin alpha subunits. Here, we show that targeted trafficking of integrins to and from the cleavage furrow is required for successful cytokinesis, and that this is regulated by Rab21. Rab21 activity, integrin-Rab21 association, and integrin endocytosis are all necessary for normal cytokinesis, which becomes impaired when integrin-mediated adhesion at the cleavage furrow fails. We also describe a chromosomal deletion and loss of Rab21 gene expression in human cancer, which leads to the accumulation of multinucleate cells. Importantly, reintroduction of Rab21 rescued this phenotype. In conclusion, Rab21-regulated integrin trafficking is essential for normal cell division, and its defects may contribute to multinucleation and genomic instability, which are hallmarks of cancer.

Paulette Gray, Ph.D.

Cancer.gov

Paulette S. Gray, Ph.D. is the Director for the Division of Extramural Activities (DEA). As the director of the division, she is responsible for the overall scientific, fiscal, and administrative management of the division, including broad strategic planning, development, implementation, and evaluation.

Montana Department of Transportation Guide to Public Involvement

DOT National Transportation Integrated Search

1996-01-01

This guide describes the various methods the Transportation Planning Division of the MDOT uses to involve the public in Division activities, and also includes a chart that provides the names of staff people responsible for various Division programs. ...

High Antioxidant Activity Facilitates Maintenance of Cell Division in Leaves of Drought Tolerant Maize Hybrids

PubMed Central

Avramova, Viktoriya; AbdElgawad, Hamada; Vasileva, Ivanina; Petrova, Alexandra S.; Holek, Anna; Mariën, Joachim; Asard, Han; Beemster, Gerrit T. S.

2017-01-01

We studied the impact of drought on growth regulation in leaves of 13 maize varieties with different drought sensitivity and geographic origins (Western Europe, Egypt, South Africa) and the inbred line B73. Combining kinematic analysis of the maize leaf growth zone with biochemical measurements at a high spatial resolution allowed us to examine the correlation between the regulation of the cellular processes cell division and elongation, and the molecular redox-regulation in response to drought. Moreover, we demonstrated differences in the response of the maize lines to mild and severe levels of water deficit. Kinematic analysis indicated that drought tolerant lines experienced less impact on leaf elongation rate due to a smaller reduction of cell production, which, in turn, was due to a smaller decrease of meristem size and number of cells in the leaf meristem. Clear differences in growth responses between the groups of lines with different geographic origin were observed in response to drought. The difference in drought tolerance between the Egyptian hybrids was significantly larger than between the European and South-African hybrids. Through biochemical analyses, we investigated whether antioxidant activity in the growth zone, contributes to the drought sensitivity differences. We used a hierarchical clustering to visualize the patterns of lipid peroxidation, H2O2 and antioxidant concentrations, and enzyme activities throughout the growth zone, in response to stress. The results showed that the lines with different geographic region used different molecular strategies to cope with the stress, with the Egyptian hybrids responding more at the metabolite level and African and the European hybrids at the enzyme level. However, drought tolerance correlated with both, higher antioxidant levels throughout the growth zone and higher activities of the redox-regulating enzymes CAT, POX, APX, and GR specifically in leaf meristems. These findings provide evidence for a link between antioxidant regulation in the leaf meristem, cell division, and drought tolerance. PMID:28210264

Publications - SR 67 | Alaska Division of Geological & Geophysical Surveys

Science.gov Websites

DGGS SR 67 Publication Details Title: Alaska's mineral industry 2011 - exploration activity Authors the mineral industry. Please take time to fill out the current mining and mineral activity - exploration activity: Alaska Division of Geological & Geophysical Surveys Special Report 67, 10 p. http

Metals and Ceramics Division progress report for period ending June 30, 1984

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brogden, I.

1984-09-01

This progress report covers the research and development activities of the Metals and Ceramics Division from January 1, 1983, through June 30, 1984. The format of the report follows the organizational structure of the division. Short summaries of technical work in progress in the various experimental groups are presented in six parts. Chapter 1 deals with the research and development activities of the Engineering Materials Section, Chapter 2 with the Processing Science and Technology Section, Chapter 3 with the Materials Science Section, Chapter 4 with Project Activities, Chapter 5 with Specialized Research Facilities and Equipment, and Chapter 6 with Miscellaneousmore » Activities.« less

Instrumentation and Controls Division Overview: Sensors Development for Harsh Environments at Glenn Research Center

NASA Technical Reports Server (NTRS)

Zeller, Mary V.; Lei, Jih-Fen

2002-01-01

The Instrumentation and Controls Division is responsible for planning, conducting and directing basic and applied research on advanced instrumentation and controls technologies for aerospace propulsion and power applications. The Division's advanced research in harsh environment sensors, high temperature high power electronics, MEMS (microelectromechanical systems), nanotechnology, high data rate optical instrumentation, active and intelligent controls, and health monitoring and management will enable self-feeling, self-thinking, self-reconfiguring and self-healing Aerospace Propulsion Systems. These research areas address Agency challenges to deliver aerospace systems with reduced size and weight, and increased functionality and intelligence for future NASA missions in advanced aeronautics, economical space transportation, and pioneering space exploration. The Division also actively supports educational and technology transfer activities aimed at benefiting all humankind.

Integrative Physical and Cognitive Training Development to Better Meet Airman Mission Requirements

DTIC Science & Technology

2015-07-26

Warfighter Interface Division Applied Neuroscience Branch Wright-Patterson AFB OH 45433 711 HPW/RHCP 11. SPONSOR/MONITOR’S REPORT NUMBER(S...Interface Division) and Erica Johnson (AFRL, Applied Neuroscience Branch) for their contributions in technical development and manuscript editing that...Liston C. Hobson J. Stickgold, R. Cognitive flexibility across the sleep–wake cycle: REM-sleep enhancement of anagram problem solving. Cogn Brain

Ethnic Division in Cyprus and a Policy Initiative on Promoting Peaceful Coexistence: Toward an Agonistic Democracy for Citizenship Education

ERIC Educational Resources Information Center

Zembylas, Michalinos

2011-01-01

This article uses as a point of departure for its analysis a recent educational policy initiative to promote peaceful coexistence in the context of ongoing ethnic division in Cyprus. It is argued that, although it seems as if the teaching of peaceful coexistence is a laudable initiative that can contribute toward unity and democratic…

Review of travel data issues in VDOT's Transportation Planning Division.

DOT National Transportation Integrated Search

1991-01-01

The Transportation Planning Division (TPD) of the Virginia Department of Transportation uses an extensive amount of travel data in both its routine planning activities and its provision of data forecasts to other divisions. Travel data consist of suc...

Lightning Talks 2015: Theoretical Division

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shlachter, Jack S.

2015-11-25

This document is a compilation of slides from a number of student presentations given to LANL Theoretical Division members. The subjects cover the range of activities of the Division, including plasma physics, environmental issues, materials research, bacterial resistance to antibiotics, and computational methods.

How-to-Do-It: Hands-on Activities that Relate Mendelian Genetics to Cell Division.

ERIC Educational Resources Information Center

McKean, Heather R.; Gibson, Linda S.

1989-01-01

Presented is an activity designed to connect Mendelian laws with the physical processes of cell division. Included are materials production, procedures and worksheets for the meiosis-mitosis game and a genetics game. (CW)

Auxin as an inducer of asymmetrical division generating the subsidiary cells in stomatal complexes of Zea mays.

PubMed

Livanos, Pantelis; Giannoutsou, Eleni; Apostolakos, Panagiotis; Galatis, Basil

2015-01-01

The data presented in this work revealed that in Zea mays the exogenously added auxins indole-3-acetic acid (IAA) and 1-napthaleneacetic acid (NAA), promoted the establishment of subsidiary cell mother cell (SMC) polarity and the subsequent subsidiary cell formation, while treatment with auxin transport inhibitors 2,3,5-triiodobenzoic acid (TIBA) and 1-napthoxyacetic acid (NOA) specifically blocked SMC polarization and asymmetrical division. Furthermore, in young guard cell mother cells (GMCs) the PIN1 auxin efflux carriers were mainly localized in the transverse GMC faces, while in the advanced GMCs they appeared both in the transverse and the lateral ones adjacent to SMCs. Considering that phosphatidyl-inositol-3-kinase (PI3K) is an active component of auxin signal transduction and that phospholipid signaling contributes in the establishment of polarity, treatments with the specific inhibitor of the PI3K LY294002 were carried out. The presence of LY294002 suppressed polarization of SMCs and prevented their asymmetrical division, whereas combined treatment with exogenously added NAA and LY294002 restricted the promotional auxin influence on subsidiary cell formation. These findings support the view that auxin is involved in Z. mays subsidiary cell formation, probably functioning as inducer of the asymmetrical SMC division. Collectively, the results obtained from treatments with auxin transport inhibitors and the appearance of PIN1 proteins in the lateral GMC faces indicate a local transfer of auxin from GMCs to SMCs. Moreover, auxin signal transduction seems to be mediated by the catalytic function of PI3K.

Auxin as an inducer of asymmetrical division generating the subsidiary cells in stomatal complexes of Zea mays

PubMed Central

Livanos, Pantelis; Giannoutsou, Eleni; Apostolakos, Panagiotis; Galatis, Basil

2015-01-01

The data presented in this work revealed that in Zea mays the exogenously added auxins indole-3-acetic acid (IAA) and 1-napthaleneacetic acid (NAA), promoted the establishment of subsidiary cell mother cell (SMC) polarity and the subsequent subsidiary cell formation, while treatment with auxin transport inhibitors 2,3,5-triiodobenzoic acid (TIBA) and 1-napthoxyacetic acid (NOA) specifically blocked SMC polarization and asymmetrical division. Furthermore, in young guard cell mother cells (GMCs) the PIN1 auxin efflux carriers were mainly localized in the transverse GMC faces, while in the advanced GMCs they appeared both in the transverse and the lateral ones adjacent to SMCs. Considering that phosphatidyl-inositol-3-kinase (PI3K) is an active component of auxin signal transduction and that phospholipid signaling contributes in the establishment of polarity, treatments with the specific inhibitor of the PI3K LY294002 were carried out. The presence of LY294002 suppressed polarization of SMCs and prevented their asymmetrical division, whereas combined treatment with exogenously added NAA and LY294002 restricted the promotional auxin influence on subsidiary cell formation. These findings support the view that auxin is involved in Z. mays subsidiary cell formation, probably functioning as inducer of the asymmetrical SMC division. Collectively, the results obtained from treatments with auxin transport inhibitors and the appearance of PIN1 proteins in the lateral GMC faces indicate a local transfer of auxin from GMCs to SMCs. Moreover, auxin signal transduction seems to be mediated by the catalytic function of PI3K. PMID:25831267

A computational perspective on autism

PubMed Central

Rosenberg, Ari; Patterson, Jaclyn Sky; Angelaki, Dora E.

2015-01-01

Autism is a neurodevelopmental disorder that manifests as a heterogeneous set of social, cognitive, motor, and perceptual symptoms. This system-wide pervasiveness suggests that, rather than narrowly impacting individual systems such as affection or vision, autism may broadly alter neural computation. Here, we propose that alterations in nonlinear, canonical computations occurring throughout the brain may underlie the behavioral characteristics of autism. One such computation, called divisive normalization, balances a neuron’s net excitation with inhibition reflecting the overall activity of the neuronal population. Through neural network simulations, we investigate how alterations in divisive normalization may give rise to autism symptomatology. Our findings show that a reduction in the amount of inhibition that occurs through divisive normalization can account for perceptual consequences of autism, consistent with the hypothesis of an increased ratio of neural excitation to inhibition (E/I) in the disorder. These results thus establish a bridge between an E/I imbalance and behavioral data on autism that is currently absent. Interestingly, our findings implicate the context-dependent, neuronal milieu as a key factor in autism symptomatology, with autism reflecting a less “social” neuronal population. Through a broader discussion of perceptual data, we further examine how altered divisive normalization may contribute to a wide array of the disorder’s behavioral consequences. These analyses show how a computational framework can provide insights into the neural basis of autism and facilitate the generation of falsifiable hypotheses. A computational perspective on autism may help resolve debates within the field and aid in identifying physiological pathways to target in the treatment of the disorder. PMID:26170299

77 FR 56215 - National Cancer Institute; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-12

... evaluate grant applications. Place: Bethesda North Marriott Hotel & Conference Center, 5701 Marinelli Road... & Logistics Branch, Division of Extramural Activities, National Cancer Institute, NIH, 6116 Executive Blvd... Review & Logistics Branch, Division of Extramural Activities, 6116 Executive Boulevard, Room 8146...

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Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-14

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75 FR 30858 - Justice Management Division; Agency Information Collection Activities: Proposed Collection...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-02

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Equality in the division of household labor: a comparative study of Jewish women and Arab Muslim women in Israel.

PubMed

Kulik, Liat

2007-08-01

In this study, the author compared perceptions of gender-based equality in the division of household labor among Jewish women (n = 60) and Arab Muslim women (n = 62) from dual-earner families in Israel. Guided by theories regarding the division of household labor, the author also explored the impact of 3 sets of variables--resources, gender-role attitudes, and job flexibility (flextime)--on perceived equality in the division of household labor. The findings revealed that the Jewish women tended to perceive the division of household labor as more egalitarian than did their Arab Muslim counterparts. Furthermore, the Jewish women had more egalitarian gender-role attitudes and more job flexibility than did the Arab Muslim women. However, all 3 sets of variables predicted perceived equality in the division of household labor to the same extent for both groups of women. Moreover, for both groups, education level correlated with attitudes toward household labor and with extent of job flexibility. Overall, the findings suggest that education may contribute to improving women's quality of life in both traditional and modem sociocultural contexts.

Validity of consumer-grade activity monitor to identify manual wheelchair propulsion in standardized activities of daily living.

PubMed

Leving, Marika T; Horemans, Henricus L D; Vegter, Riemer J K; de Groot, Sonja; Bussmann, Johannes B J; van der Woude, Lucas H V

2018-01-01

Hypoactive lifestyle contributes to the development of secondary complications and lower quality of life in wheelchair users. There is a need for objective and user-friendly physical activity monitors for wheelchair-dependent individuals in order to increase physical activity through self-monitoring, goal setting, and feedback provision. To determine the validity of Activ8 Activity Monitors to 1) distinguish two classes of activities: independent wheelchair propulsion from other non-propulsive wheelchair-related activities 2) distinguish five wheelchair-related classes of activities differing by the movement intensity level: sitting in a wheelchair (hands may be moving but wheelchair remains stationary), maneuvering, and normal, high speed or assisted wheelchair propulsion. Sixteen able-bodied individuals performed sixteen various standardized 60s-activities of daily living. Each participant was equipped with a set of two Activ8 Professional Activity Monitors, one at the right forearm and one at the right wheel. Task classification by the Active8 Monitors was validated using video recordings. For the overall agreement, sensitivity and positive predictive value, outcomes above 90% are considered excellent, between 70 and 90% good, and below 70% unsatisfactory. Division in two classes resulted in overall agreement of 82.1%, sensitivity of 77.7% and positive predictive value of 78.2%. 84.5% of total duration of all tasks was classified identically by Activ8 and based on the video material. Division in five classes resulted in overall agreement of 56.6%, sensitivity of 52.8% and positive predictive value of 51.9%. 59.8% of total duration of all tasks was classified identically by Activ8 and based on the video material. Activ8 system proved to be suitable for distinguishing between active wheelchair propulsion and other non-propulsive wheelchair-related activities. The ability of the current system and algorithms to distinguish five various wheelchair-related activities is unsatisfactory.

Validity of consumer-grade activity monitor to identify manual wheelchair propulsion in standardized activities of daily living

PubMed Central

Horemans, Henricus L. D.; Vegter, Riemer J. K.; de Groot, Sonja; Bussmann, Johannes B. J.; van der Woude, Lucas H. V.

2018-01-01

Background Hypoactive lifestyle contributes to the development of secondary complications and lower quality of life in wheelchair users. There is a need for objective and user-friendly physical activity monitors for wheelchair-dependent individuals in order to increase physical activity through self-monitoring, goal setting, and feedback provision. Objective To determine the validity of Activ8 Activity Monitors to 1) distinguish two classes of activities: independent wheelchair propulsion from other non-propulsive wheelchair-related activities 2) distinguish five wheelchair-related classes of activities differing by the movement intensity level: sitting in a wheelchair (hands may be moving but wheelchair remains stationary), maneuvering, and normal, high speed or assisted wheelchair propulsion. Methods Sixteen able-bodied individuals performed sixteen various standardized 60s-activities of daily living. Each participant was equipped with a set of two Activ8 Professional Activity Monitors, one at the right forearm and one at the right wheel. Task classification by the Active8 Monitors was validated using video recordings. For the overall agreement, sensitivity and positive predictive value, outcomes above 90% are considered excellent, between 70 and 90% good, and below 70% unsatisfactory. Results Division in two classes resulted in overall agreement of 82.1%, sensitivity of 77.7% and positive predictive value of 78.2%. 84.5% of total duration of all tasks was classified identically by Activ8 and based on the video material. Division in five classes resulted in overall agreement of 56.6%, sensitivity of 52.8% and positive predictive value of 51.9%. 59.8% of total duration of all tasks was classified identically by Activ8 and based on the video material. Conclusions Activ8 system proved to be suitable for distinguishing between active wheelchair propulsion and other non-propulsive wheelchair-related activities. The ability of the current system and algorithms to distinguish five various wheelchair-related activities is unsatisfactory. PMID:29641582

77 FR 28476 - Political Contributions by Certain Investment Advisers

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2012-05-15

...] Political Contributions by Certain Investment Advisers AGENCY: Securities and Exchange Commission. ACTION... Investment Advisers Act of 1940 (``Advisers Act'') to correct an inadvertent error in the rule as published...-6787 or [email protected] , Office of Investment Adviser Regulation, Division of Investment Management, U...

Competitive Advantage in Intercollegiate Athletics: Role of Intangible Resources

PubMed Central

Won, Doyeon; Chelladurai, Packianathan

2016-01-01

The present research explored the dynamics of competitive advantages in intercollegiate athletics by investigating the contribution of intangible resources (i.e., athletic and academic reputations) on the generation of more tangible resources (i.e., human and financial resources), which in turn influence the athletic performance (i.e., winning record) and academic performance (i.e., graduation rates), and gender equity. The research was based entirely on archival data of 324 NCAA Division I member institutions. The results of the SEM supported the study’s basic arguments that tangible resources are the sources of competitive advantages in Division I intercollegiate athletics, and that intangible resources contribute to the generation of tangible resources. PMID:26731118

76 FR 27354 - Agency Information Collection Activities; Existing Collection, Comments Requested: Approval of an...

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Proceedings of the Annual Meeting of the Association for Education in Journalism and Mass Communication (85th, Miami, Florida, August 5-8, 2002). Commission on the Status of Women Division.

ERIC Educational Resources Information Center

2002

The Commission on the Status of Women Division of the proceedings contains the following 6 papers: "Relationship Content in Four Men's and Women's Magazines" (Alexis Zachary and Bryan Denham); "Mind the Gender Gap: Gender Differences in Motivation to Contribute Online Content" (Cindy Royal); "Peering through the Glass…

The Significance of Family, Environment, and College Preparation: A Study of Factors Influencing Graduation and Persistence Rates of African American Males Playing Division I Basketball

ERIC Educational Resources Information Center

Mitchell, Enzley, IV

2017-01-01

The purpose of this study was to identify specific external factors including family composition, pre-college environment, and college preparation that contribute to why some African American males playing basketball at the NCAA Division I level graduate and persist while others do not. Despite an aggressive advertising campaign from the NCAA…

78 FR 36200 - National Cancer Institute; Notice of Closed Meetings

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2013-06-17

... personal privacy. Name of Committee: National Cancer Institute Special Emphasis Panel; Cancer Biology and... Logistics Branch, Division of Extramural Activities, National Cancer Institute, NIH, 9609 Medical Center... Branch, Division of Extramural Activities, National Cancer Institute, NIH, 9609 Medical Center Drive...

Thematic Synthesis of Post Activity Reviews: Lessons Relating to Management of the Simulation Environment Supporting Activity Vital Fire in May 2014

DTIC Science & Technology

2015-03-01

Supporting Activity Vital Fire in May 2014 Glen Pearce Land Division Defence Science and Technology Organisation DSTO-TN-1408...UNCLASSIFIED Published by Land Division DSTO Defence Science and Technology Organisation 506 Lorimer St Fishermans Bend Victoria 3207 Australia...REQUIREMENTS .............................................................................. 1 2.1 Cognitive and metacognitive performance

77 FR 66636 - Agency Information Collection Activities; Existing Collection, Comments Requested: Approval of an...

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... (FBI), Criminal Justice Information Services (CJIS) Division's NICS Section will be submitting the... Program Analyst, Federal Bureau of Investigation, Criminal Justice Information Services Division, National... Information Services (CJIS) Division of the Federal Bureau of Investigation (FBI), Department of Justice (DOJ...

Teaching Cell Division: Basics and Recommendations.

ERIC Educational Resources Information Center

Smith, Mike U.; Kindfield, Ann C. H.

1999-01-01

Presents a concise overview of cell division that includes only the essential concepts necessary for understanding genetics and evolution. Makes recommendations based on published research and teaching experiences that can be used to judge the merits of potential activities and materials for teaching cell division. Makes suggestions regarding the…

Research and technology, 1990

NASA Technical Reports Server (NTRS)

1990-01-01

Selected research and technology activities at Ames Research Center, including the Moffett Field site and the Dryden Flight Research Facility, are summarized. These accomplishments exemplify the Center's varied and highly productive research efforts for 1990. The activities addressed are under the directories of: (1) aerospace systems which contains aircraft technology, full-scale aerodynamics research, information sciences, aerospace human factors research, and flight systems and simulation research divisions; (2) Dryden flight research facility which contains research engineering division; (3) aerophysics which contains aerodynamics, fluid dynamics, and thermosciences divisions; and (4) space research which contains advanced life support, space projects, earth system science, life science, and space science divisions, and search for extraterrestrial intelligence and space life sciences payloads offices.

Arabidopsis  SABRE and CLASP interact to stabilize cell division plane orientation and planar polarity

PubMed Central

Pietra, Stefano; Gustavsson, Anna; Kiefer, Christian; Kalmbach, Lothar; Hörstedt, Per; Ikeda, Yoshihisa; Stepanova, Anna N.; Alonso, Jose M.; Grebe, Markus

2013-01-01

The orientation of cell division and the coordination of cell polarity within the plane of the tissue layer (planar polarity) contribute to shape diverse multicellular organisms. The root of Arabidopsis thaliana displays regularly oriented cell divisions, cell elongation and planar polarity providing a plant model system to study these processes. Here we report that the SABRE protein, which shares similarity with proteins of unknown function throughout eukaryotes, has important roles in orienting cell division and planar polarity. SABRE localizes at the plasma membrane, endomembranes, mitotic spindle and cell plate. SABRE stabilizes the orientation of CLASP-labelled preprophase band microtubules predicting the cell division plane, and of cortical microtubules driving cell elongation. During planar polarity establishment, sabre is epistatic to clasp at directing polar membrane domains of Rho-of-plant GTPases. Our findings mechanistically link SABRE to CLASP-dependent microtubule organization, shedding new light on the function of SABRE-related proteins in eukaryotes. PMID:24240534

Hunting the mechanisms of self-renewal of immortal cell populations by means of real-time imaging of living cells.

PubMed

Kvitko, O V; Koneva, I I; Sheiko, Y I; Anisovich, M V

2005-12-01

The causes of the indefinite propagation of immortalized cell populations remain insufficiently understood, that hinders the research of such fundamental processes as ageing and cancer. In this study the interrelations between clonal proliferation and abnormalities of mitotic divisions in the immortalized cell line established from the mouse embryo were investigated with the aid of computerized microscopy of living cells. 3 mitoses with three daughter cells and 7 asymmetric mitoses which generated two daughter cells of conspicuously different sizes were registered among 71 mitotic divisions in the individual cell genealogy. Abnormal mitotic divisions either did not slow the proliferation in cell clones compared with progenies of cells that divided by means of normal mitoses or were followed by the acceleration of divisions in consecutive cell generations. These data suggest that abnormal mitotic divisions may contribute to the maintenance of the immortalized state of cell populations by means of generating chromosomal instability.

78 FR 53154 - National Cancer Institute; Notice of Closed Meetings

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2013-08-28

... Logistics Branch, Division of Extramural Activities, National Cancer Institute, NIH, 9609 Medical Center... Logistics Branch, Division of Extramural Activities, National Cancer Institute, NIH, 9609 Medical Center... applications. Place: National Cancer Institute Shady Grove, 9609 Medical Center Drive, Room 7W034, Rockville...

77 FR 65694 - Statement of Organization, Functions and Delegations of Authority

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2012-10-30

... public relations and media communications, as well as activities related to congressional inquiries, and...) updates the functional statement for the Division of Public Health and Interdisciplinary Education (RPF... Health Service Corps (RU5); (4) Division of Nursing and Public Health (RU6); (5) Division of External...

77 FR 19718 - Ford Motor Company Twin Cities Assembly Plant Vehicle Operations Division Including On-Site...

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... Cities Assembly Plant Vehicle Operations Division Including On-Site Leased Workers From AEROTEK, Albers... Industries, Waste Management, VMX, Nascote Industries, Delphi Electronics & Safety, Unicomm, And Pacer... Operations Division, St. Paul, Minnesota. The workers are engaged in activities related to the production of...

What's counted as a reindeer herder? Gender and the adaptive capacity of Sami reindeer herding communities in Sweden.

PubMed

Buchanan, Astri; Reed, Maureen G; Lidestav, Gun

2016-12-01

Researchers of adaptive capacity and sustainable livelihoods have frequently used social, cultural, human, economic and institutional capitals to better understand how rural and resource-dependent communities address environmental, social and economic stresses. Yet few studies have considered how men and women contribute differently to these capitals to support community resilience overall. Our research sought to understand the differential contributions of Sami men and women to the adaptive capacity of reindeer husbandry and reindeer herding communities in northern Sweden. Our focus revealed a gendered division of labour in reindeer herding as an economic enterprise as well as gendered contributions to a broader conceptualization of reindeer husbandry as a family and community-based practice, and as a livelihood and cultural tradition. Based on our results, we recommend that community resilience be enhanced by generating more opportunities for men to achieve higher levels of human and economic capital (particularly outside of herding activities) and encouraging women to contribute more directly to institutional capital by participating in the formation and implementation of legislation, policies and plans.

RESEARCH ACTIVITIES AT THE US EPA'S GULF ECOLOGY DIVISION

EPA Science Inventory

The purpose of this talk was to present an overview of research activities at the US EPA's Office of Research and Development, Gulf Ecology Division located on Pensacola Beach, Florida. The talk was organized into three major sections. The first section covered my educational b...

Solutions Network Formulation Report. The Potential Contribution of the International GPM Program to the NOAA Estuarine Reserves Division's System-wide Monitoring Program

NASA Technical Reports Server (NTRS)

Hilbert, Kent; Anderson, Daniel; Lewis, David

2007-01-01

Data collected via the International GPM Program could be used to provide a solution for the NOAA Estuarine Reserves Division s System-wide Monitoring Program by augmenting in situ rainfall measurements with data acquired via future satellite-acquired precipitation data. This Candidate Solution is in alignment with the Coastal Management National Application and will benefit society by assisting in estuary preservation.

The zebrafish maternal-effect gene cellular atoll encodes the centriolar component sas-6 and defects in its paternal function promote whole genome duplication.

PubMed

Yabe, Taijiro; Ge, Xiaoyan; Pelegri, Francisco

2007-12-01

A female-sterile zebrafish maternal-effect mutation in cellular atoll (cea) results in defects in the initiation of cell division starting at the second cell division cycle. This phenomenon is caused by defects in centrosome duplication, which in turn affect the formation of a bipolar spindle. We show that cea encodes the centriolar coiled-coil protein Sas-6, and that zebrafish Cea/Sas-6 protein localizes to centrosomes. cea also has a genetic paternal contribution, which when mutated results in an arrested first cell division followed by normal cleavage. Our data supports the idea that, in zebrafish, paternally inherited centrosomes are required for the first cell division while maternally derived factors are required for centrosomal duplication and cell divisions in subsequent cell cycles. DNA synthesis ensues in the absence of centrosome duplication, and the one-cycle delay in the first cell division caused by cea mutant sperm leads to whole genome duplication. We discuss the potential implications of these findings with regards to the origin of polyploidization in animal species. In addition, the uncoupling of developmental time and cell division count caused by the cea mutation suggests the presence of a time window, normally corresponding to the first two cell cycles, which is permissive for germ plasm recruitment.

Timely Endocytosis of Cytokinetic Enzymes Prevents Premature Spindle Breakage during Mitotic Exit

PubMed Central

Onishi, Masayuki; Yeong, Foong May

2016-01-01

Cytokinesis requires the spatio-temporal coordination of membrane deposition and primary septum (PS) formation at the division site to drive acto-myosin ring (AMR) constriction. It has been demonstrated that AMR constriction invariably occurs only after the mitotic spindle disassembly. It has also been established that Chitin Synthase II (Chs2p) neck localization precedes mitotic spindle disassembly during mitotic exit. As AMR constriction depends upon PS formation, the question arises as to how chitin deposition is regulated so as to prevent premature AMR constriction and mitotic spindle breakage. In this study, we propose that cells regulate the coordination between spindle disassembly and AMR constriction via timely endocytosis of cytokinetic enzymes, Chs2p, Chs3p, and Fks1p. Inhibition of endocytosis leads to over accumulation of cytokinetic enzymes during mitotic exit, which accelerates the constriction of the AMR, and causes spindle breakage that eventually could contribute to monopolar spindle formation in the subsequent round of cell division. Intriguingly, the mitotic spindle breakage observed in endocytosis mutants can be rescued either by deleting or inhibiting the activities of, CHS2, CHS3 and FKS1, which are involved in septum formation. The findings from our study highlight the importance of timely endocytosis of cytokinetic enzymes at the division site in safeguarding mitotic spindle integrity during mitotic exit. PMID:27447488

Bottom sediments and nutrients in the tidal Potomac system, Maryland and Virginia

USGS Publications Warehouse

Glenn, Jerry L.

1988-01-01

The characteristics and distributions of near-surface bottom sediments and of nutrients in the sediments provide information on modern sediment and nutrient sources, sedimentation environments, and geochemical reactions in the tidal Potomac system, Maryland and Virginia. This information is fundamental to an improved understanding of sedimentation and eutrophication problems in the tidal Potomac system. The tidal Potomac system consists of 1,230 square kilometers of intertidal to subtidal Potomac mainstem and tributary streambed from the heads-of-tides to Chesapeake Bay. Tidal Potomac sediments are dominantly silt and clay except in local areas. An average sediment sample is about two-thirds silt and clay (fine) particles and one-third sand (coarse) particles. The mean of the median size of all samples is 6.60 phi, or 0.010 millimeters. Sorting generally is poor and the average sediment is skewed toward the fine tail of the size-distribution curve. Mean particle-size measures have large standard deviations. Among geomorphic units, two distinctly different size populations are found; fine (median phi about 9), and poorly sorted (sorting about 3) sediments in the channel and the smooth flat, and coarse (median phi about 2), and well sorted (sorting about 1) sediments in the shoreline flat and the irregular slope. Among mainstem hydrologic divisions, an average sediment from the river and the estuary division is coarser and more variable than an average sediment from the transition division. Substantial concentrations of total carbon, total nitrogen, and total phosphorus, and limited amounts of inorganic carbon, ammonia nitrogen and nitrite plus nitrate nitrogen occur in tidal Potomac sediments. An average tidal Potomac sediment sample weighing 1 kilogram contains about 21,000 milligrams of total carbon, 2,400 milligrams of total nitrogen, 1,200 milligrams of total phosphorus, 600 milligrams of inorganic carbon, 170 milligrams of ammonia nitrogen, and 2 milligrams of nitrite plus nitrate nitrogen. Total carbon, nitrogen, and phosphorus have an average ratio by weight of 18:2:1 and an average ratio by atoms of 94:8:1. Nutrient concentrations and nutrient ratios have large ranges and standard deviations. Nutrient concentrations usually are closely related to particle size; large concentrations are characteristic of fine sediments in the channel and the smooth flat, and small concentrations are typical of coarse sediments in the shoreline flat and the irregular slope. Concentrations typically decrease from the river division to the estuary division. Mainstem and tributaries show no statistically significant difference in mean particle-size measures or mean nutrient concentrations. Tributaries do not contribute large quantities of sediment with diverse texture or nutrient content to the Potomac mainstem. Particle-size measures and nutrient concentrations in the mainstem are significantly related to hydrologic divisions and geomorphic units; that is, particle size and nutrients vary significantly along and across the Potomac mainstem. Lateral variations in particle size and nutrient content are more pronounced and contribute more to significant relations than longitudinal variations contribute. The mean values for the median particle size and for the percentage of sand indicate significant variations among hydrologic divisions for samples from a geomorphic unit, and among geomorphic units, for samples from a hydrologic division. Sediments of channels and smooth flats in the river division commonly are coarser than sediments of channels and smooth flats in the transition and the estuary divisions. Shoreline flats in the estuary division are coarser than shoreline flats in the river division. Shoreline flats and irregular slopes in each hydrologic division generally are significantly coarser than channels and smooth flats. Relations between particle-size measures and geomorphic units show progressively larger cor

77 FR 42501 - Agency Information Collection Activities; Submission for Office of Management and Budget Review...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-19

...] Agency Information Collection Activities; Submission for Office of Management and Budget Review; Comment Request; Guidance for Industry on Formal Dispute Resolution; Appeals Above the Division Level AGENCY: Food... the Division Level--(OMB Control Number 0910-0430)--(Extension) This information collection approval...

Publications - GMC 381 | Alaska Division of Geological & Geophysical

Science.gov Websites

DGGS GMC 381 Publication Details Title: 1974 summary report of exploration activities, Orange Hill information. Quadrangle(s): Nabesna Bibliographic Reference Trautwein, C.M., 2010, 1974 summary report of exploration activities, Orange Hill, Alaska: Alaska Division of Geological & Geophysical Surveys Geologic

75 FR 39546 - National Cancer Institute; Notice of Closed Meetings

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2010-07-09

...; Integrative Cancer Biology in the Tumor Microenvironment (U01). Date: July 22, 2010. Time: 8 a.m. to 5 p.m..., Special Review and Logistics Branch, Division of Extramural Activities, National Cancer Institute, 6116... Review and Logistic Branch, Division of Extramural Activities, NCI, National Institutes of Health, 6116...

78 FR 8155 - National Cancer Institute; Notice of Closed Meetings

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2013-02-05

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Publications - DDS 6 | Alaska Division of Geological & Geophysical Surveys

Science.gov Websites

Publications Geologic Materials Center General Information Inventory Monthly Report Hours and Location Policy DGGS DDS 6 Publication Details Title: Historically active volcanoes of Alaska Authors: Cameron, C.E , C.E., and Schaefer, J.R., 2016, Historically active volcanoes of Alaska: Alaska Division of Geological

Dynamin-related protein 1 mediates mitochondria-dependent apoptosis in chlorpyrifos-treated SH-SY5Y cells.

PubMed

Park, Jae Hyeon; Ko, Juyeon; Hwang, Jungwook; Koh, Hyun Chul

2015-12-01

Recent studies have demonstrated that dynamin-related protein 1 (Drp1), a mitochondrial fission protein, mediates mitochondria-dependent apoptosis through mitochondrial division. However, little is known about the mechanism by which Drp1 modulates apoptosis in response to chlorpyrifos (CPF)-induced toxicity. In this study, we determined that CPF-induced mitochondrial apoptosis is mediated by Drp1 translocation in SH-SY5Y human neuroblastoma cells. Our results showed that CPF treatment induced intrinsic apoptosis by activating caspase-9, caspase-3, and cytochrome c release in SH-SY5Y cells. Cytosolic Drp1 translocated to the mitochondria in CPF-treated cells and was phosphorylated at Ser616. Treating cells with CPF induced the generation of reactive oxygen species (ROS) and activation of mitogen-activated protein kinases (MAPKs). Inhibiting this ROS generation and MAPK activation abolished CPF-induced expression of phospho-Drp1. Furthermore, Drp1 was required for p53 to translocate to the mitochondria under CPF-induced oxidative stress. Treating cells with mitochondrial-division inhibitor-1 (mdivi-1), which blocks Drp1 translocation, increased the viability of CPF-treated cells by abrogating Drp1 translocation and caspase-3 activation. Specifically, pretreating cells with mdivi-1 inhibited Bax translocation to the mitochondria by blocking p53 signaling. Taken together, these data reveal a novel mechanism by which Drp1 activates mitochondrial-dependent apoptosis and indicate that inhibiting Dpr1 function can protect against CPF-induced cytotoxicity. We propose that inhibiting Drp1 is a possible therapeutic approach for pesticide-induced toxicity when hyperactivated Drp1 contributes to pathology. Crown Copyright © 2015. Published by Elsevier B.V. All rights reserved.

Technology Development, Evaluation, and Application (TDEA) FY 2001 Progress Report Environment, Safety, and Health (ESH) Division

DOE Office of Scientific and Technical Information (OSTI.GOV)

L.G. Hoffman; K. Alvar; T. Buhl

2002-05-01

This progress report presents the results of 11 projects funded ($500K) in FY01 by the Technology Development, Evaluation, and Application (TDEA) Committee of the Environment, Safety, and Health Division (ESH). Five projects fit into the Health Physics discipline, 5 projects are environmental science and one is industrial hygiene/safety. As a result of their TDEA-funded projects, investigators have published sixteen papers in professional journals, proceedings, or Los Alamos reports and presented their work at professional meetings. Supplement funds and in-kind contributions, such as staff time, instrument use, and workspace, were also provided to TDEA-funded projects by organizations external to ESH Divisions.

Cell division is dispensable but not irrelevant in Streptomyces.

PubMed

McCormick, Joseph R

2009-12-01

In part, members of the genus Streptomyces have been studied because they produce many important secondary metabolites with antibiotic activity and for the interest in their relatively elaborate life cycle. These sporulating filamentous bacteria are remarkably synchronous for division and genome segregation in specialized aerial hyphae. Streptomycetes share some, but not all, of the division genes identified in the historic model rod-shaped organisms. Curiously, normally essential cell division genes are dispensable for growth and viability of Streptomyces coelicolor. Mainly, cell division plays a more important role in the developmental phase of life than during vegetative growth. Dispensability provides an advantageous genetic system to probe the mechanisms of division proteins, especially those with functions that are poorly understood.

Contribution of the Staphylococcus aureus Atl AM and GL murein hydrolase activities in cell division, autolysis, and biofilm formation.

PubMed

Bose, Jeffrey L; Lehman, McKenzie K; Fey, Paul D; Bayles, Kenneth W

2012-01-01

The most prominent murein hydrolase of Staphylococcus aureus, AtlA, is a bifunctional enzyme that undergoes proteolytic cleavage to yield two catalytically active proteins, an amidase (AM) and a glucosaminidase (GL). Although the bifunctional nature of AtlA has long been recognized, most studies have focused on the combined functions of this protein in cell wall metabolism and biofilm development. In this study, we generated mutant derivatives of the clinical S. aureus isolate, UAMS-1, in which one or both of the AM and GL domains of AtlA have been deleted. Examination of these strains revealed that each mutant exhibited growth rates comparable to the parental strain, but showed clumping phenotypes and lysis profiles that were distinct from the parental strain and each other, suggesting distinct roles in cell wall metabolism. Given the known function of autolysis in the release of genomic DNA for use as a biofilm matrix molecule, we also tested the mutants in biofilm assays and found both AM and GL necessary for biofilm development. Furthermore, the use of enzymatically inactive point mutations revealed that both AM and GL must be catalytically active for S. aureus to form a biofilm. The results of this study provide insight into the relative contributions of AM and GL in S. aureus and demonstrate the contribution of Atl-mediated lysis in biofilm development.

Environmental Sciences Division annual progress report for period ending September 30, 1991

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1992-04-01

This progress report summarizes the research and development activities conducted in the Environmental Sciences Division of Oak Ridge National Laboratory during the period October 1, 1990, through September 30, 1991. The report is structured to provide descriptions of current activities and accomplishments in each of the division`s major organizational units. Following the sections describing the organizational units is a section devoted to lists of information necessary to convey the scope of the work in the division. The Environmental Sciences Division (ESD) at Oak Ridge National Laboratory (ORNL) conducts environmental research and analyses associated with both energy technology development and themore » interactions between people and the environment. The division engages in basic and applied research for a diverse list of sponsors. While the US Department of Energy (DOE) is the primary sponsor ESD staff also perform research for other federal agencies, state agencies, and private industry. The division works collaboratively with federal agencies, universities, and private organizations in achieving its research objectives and hosts a large number of visiting investigators from these organizations. Given the diverse interdisciplinary specialization of its staff, ESD provides technical expertise on complex environmental problems and renders technical leadership for major environmental issues of national and local concern. This progress report highlights many of ESD`s accomplishment in these and other areas in FY 1991.« less

Panta rhei: The APC/C at steady state

PubMed Central

2013-01-01

The anaphase-promoting complex or cyclosome (APC/C) is a conserved, multisubunit E3 ubiquitin (Ub) ligase that is active both in dividing and in postmitotic cells. Its contributions to life are especially well studied in the domain of cell division, in which the APC/C lies at the epicenter of a regulatory network that controls the directionality and timing of cell cycle events. Biochemical and structural work is shedding light on the overall organization of APC/C subunits and on the mechanism of substrate recognition and Ub chain initiation and extension as well as on the molecular mechanisms of a checkpoint that seizes control of APC/C activity during mitosis. Here, we review how these recent advancements are modifying our understanding of the APC/C. PMID:23589490

Sustainable production of wood and non-wood forest products: Proceedings of IUFRO Division 5 Research Groups 5.11 and 5.12, Rotorua, New Zealand, March 11–15, 2003.

Treesearch

E.M. Donoghue; G.L. Benson; J.L. Chamberlain

2004-01-01

This proceedings is a collection of 18 papers and extended abstracts based on talks presented at the International Union of Forest Research Organizations (IUFRO) All Division 5 Conference, held in Rotorua, New Zealand, March 11–15, 2003. This conference emphasized the many ways that forest products research can contribute to sustainable choices in forest management....

Spontaneous Division and Motility in Active Nematic Droplets

NASA Astrophysics Data System (ADS)

Giomi, Luca; DeSimone, Antonio

2014-04-01

We investigate the mechanics of an active droplet endowed with internal nematic order and surrounded by an isotropic Newtonian fluid. Using numerical simulations we demonstrate that, due to the interplay between the active stresses and the defective geometry of the nematic director, this system exhibits two of the fundamental functions of living cells: spontaneous division and motility, by means of self-generated hydrodynamic flows. These behaviors can be selectively activated by controlling a single physical parameter, namely, an active variant of the capillary number.

Deconstructing Interocular Suppression: Attention and Divisive Normalization

PubMed Central

Li, Hsin-Hung; Carrasco, Marisa; Heeger, David J.

2015-01-01

In interocular suppression, a suprathreshold monocular target can be rendered invisible by a salient competitor stimulus presented in the other eye. Despite decades of research on interocular suppression and related phenomena (e.g., binocular rivalry, flash suppression, continuous flash suppression), the neural processing underlying interocular suppression is still unknown. We developed and tested a computational model of interocular suppression. The model included two processes that contributed to the strength of interocular suppression: divisive normalization and attentional modulation. According to the model, the salient competitor induced a stimulus-driven attentional modulation selective for the location and orientation of the competitor, thereby increasing the gain of neural responses to the competitor and reducing the gain of neural responses to the target. Additional suppression was induced by divisive normalization in the model, similar to other forms of visual masking. To test the model, we conducted psychophysics experiments in which both the size and the eye-of-origin of the competitor were manipulated. For small and medium competitors, behavioral performance was consonant with a change in the response gain of neurons that responded to the target. But large competitors induced a contrast-gain change, even when the competitor was split between the two eyes. The model correctly predicted these results and outperformed an alternative model in which the attentional modulation was eye specific. We conclude that both stimulus-driven attention (selective for location and feature) and divisive normalization contribute to interocular suppression. PMID:26517321

Deconstructing Interocular Suppression: Attention and Divisive Normalization.

PubMed

Li, Hsin-Hung; Carrasco, Marisa; Heeger, David J

2015-10-01

In interocular suppression, a suprathreshold monocular target can be rendered invisible by a salient competitor stimulus presented in the other eye. Despite decades of research on interocular suppression and related phenomena (e.g., binocular rivalry, flash suppression, continuous flash suppression), the neural processing underlying interocular suppression is still unknown. We developed and tested a computational model of interocular suppression. The model included two processes that contributed to the strength of interocular suppression: divisive normalization and attentional modulation. According to the model, the salient competitor induced a stimulus-driven attentional modulation selective for the location and orientation of the competitor, thereby increasing the gain of neural responses to the competitor and reducing the gain of neural responses to the target. Additional suppression was induced by divisive normalization in the model, similar to other forms of visual masking. To test the model, we conducted psychophysics experiments in which both the size and the eye-of-origin of the competitor were manipulated. For small and medium competitors, behavioral performance was consonant with a change in the response gain of neurons that responded to the target. But large competitors induced a contrast-gain change, even when the competitor was split between the two eyes. The model correctly predicted these results and outperformed an alternative model in which the attentional modulation was eye specific. We conclude that both stimulus-driven attention (selective for location and feature) and divisive normalization contribute to interocular suppression.

Diverse behaviors of outer radial glia in developing ferret and human cortex.

PubMed

Gertz, Caitlyn C; Lui, Jan H; LaMonica, Bridget E; Wang, Xiaoqun; Kriegstein, Arnold R

2014-02-12

The dramatic increase in neocortical size and folding during mammalian brain evolution has been attributed to the elaboration of the subventricular zone (SVZ) and the associated increase in neural progenitors. However, recent studies have shown that SVZ size and the abundance of resident progenitors do not directly predict cortical topography, suggesting that complex behaviors of the progenitors themselves may contribute to the overall size and shape of the adult cortex. Using time-lapse imaging, we examined the dynamic behaviors of SVZ progenitors in the ferret, a gyrencephalic carnivore, focusing our analysis on outer radial glial cells (oRGs). We identified a substantial population of oRGs by marker expression and their unique mode of division, termed mitotic somal translocation (MST). Ferret oRGs exhibited diverse behaviors in terms of division location, cleavage angle, and MST distance, as well as fiber orientation and dynamics. We then examined the human fetal cortex and found that a subset of human oRGs displayed similar characteristics, suggesting that diversity in oRG behavior may be a general feature. Similar to the human, ferret oRGs underwent multiple rounds of self-renewing divisions but were more likely to undergo symmetric divisions that expanded the oRG population, as opposed to producing intermediate progenitor cells (IPCs). Differences in oRG behaviors, including proliferative potential and daughter cell fates, may contribute to variations in cortical structure between mammalian species.

The ORNL Chemical Technology Division, 1950-1994

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jolley, R.L.; Genung, R.K.; McNeese, L.E.

1994-10-01

This document attempts to reconstruct the role played by the Chemical Technology Division (Chem Tech) of the Oak Ridge National Laboratory (ORNL) in the atomic era since the 1940`s related to the development and production of nuclear weapons and power reactors. Chem Tech`s early contributions were landmark pioneering studies. Unknown and dimly perceived problems like chemical hazards, radioactivity, and criticality had to be dealt with. New chemical concepts and processes had to be developed to test the new theories being developed by physicists. New engineering concepts had to be developed and demonstrated in order to build facilities and equipment thatmore » had never before been attempted. Chem Tech`s role was chemical separations, especially uranium and plutonium, and nuclear fuel reprocessing. With diversification of national and ORNL missions, Chem Tech undertook R&D studies in many areas including biotechnology; clinical and environmental chemistry; nuclear reactors; safety regulations; effective and safe waste management and disposal; computer modeling and informational databases; isotope production; and environmental control. The changing mission of Chem Tech are encapsulated in the evolving activities.« less

EVALUATED NUCLEAR STRUCTURE DATA FILE AND RELATED PRODUCTS.

DOE Office of Scientific and Technical Information (OSTI.GOV)

TULI,J.K.

The Evaluated Nuclear Structure Data File (ENSDF) is a leading resource for the experimental nuclear data. It is maintained and distributed by the National Nuclear Data Center, Brookhaven National Laboratory. The file is mainly contributed to by an international network of evaluators under the auspice of the International Atomic Energy Agency. The ENSDF is updated, generally by mass number, i.e., evaluating together all isobars for a given mass number. If, however, experimental activity in an isobaric chain is limited to a particular nuclide then only that nuclide is updated. The evaluations are published in the journal Nuclear Data Sheets, Academicmore » Press, a division of Elsevier.« less

76 FR 62812 - Agency Information Collection Activities; Submission for Office of Management and Budget Review...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-11

... information to OMB for review and clearance. Appeals of Science-Based Decisions Above the Division Level at...] Agency Information Collection Activities; Submission for Office of Management and Budget Review; Comment Request; Appeals of Science- Based Decisions Above the Division Level at the Center for Veterinary...

75 FR 1082 - Civil Rights Division; Agency Information Collection Activities: Proposed Collection; Comments...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-08

... DEPARTMENT OF JUSTICE [OMB Number 1190-0001] Civil Rights Division; Agency Information Collection Activities: Proposed Collection; Comments Requested ACTION: 60[dash]Day Notice of Information Collection Under Review: Procedures for the Administration of Section 5 of the Voting Rights Act of 1965. The Department of Justice (DOJ), CRT will be...

75 FR 11916 - Chrysler LLC, Manufacturing Truck and Activity Division, Jefferson North Assembly Plant...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-12

..., Manufacturing Truck and Activity Division, Jefferson North Assembly Plant, Including On-Site Leased Workers From..., Jefferson North Assembly Plant, Detroit, Michigan. The notice was published in the Federal Register on April... substantial portion of which are shipped to an affiliated plant where they are used in the assembly of...

NRCL-70, Review of the Activities of the Laboratories 1970.

ERIC Educational Resources Information Center

National Research Council of Canada, Ottawa (Ontario).

Included are descriptions of activities of each of the 12 laboratories in the National Research Council of Canada, including background information and a summary of the studies (research) and results. The 12 laboratories in the NRCL are the following: Atlantic Regional Laboratory, Biochemistry Laboratory, Division of Biology, Division of Building…

Geometric Reasoning in an Active-Engagement Upper-Division E&M Classroom

ERIC Educational Resources Information Center

Cerny, Leonard Thomas

2012-01-01

A combination of theoretical perspectives is used to create a rich description of student reasoning when facing a highly-geometric electricity and magnetism problem in an upper-division active-engagement physics classroom at Oregon State University. Geometric reasoning as students encounter problem situations ranging from familiar to novel is…

Cell division cycle 45 promotes papillary thyroid cancer progression via regulating cell cycle.

PubMed

Sun, Jing; Shi, Run; Zhao, Sha; Li, Xiaona; Lu, Shan; Bu, Hemei; Ma, Xianghua

2017-05-01

Cell division cycle 45 was reported to be overexpressed in some cancer-derived cell lines and was predicted to be a candidate oncogene in cervical cancer. However, the clinical and biological significance of cell division cycle 45 in papillary thyroid cancer has never been investigated. We determined the expression level and clinical significance of cell division cycle 45 using The Cancer Genome Atlas, quantitative real-time polymerase chain reaction, and immunohistochemistry. A great upregulation of cell division cycle 45 was observed in papillary thyroid cancer tissues compared with adjacent normal tissues. Furthermore, overexpression of cell division cycle 45 positively correlates with more advanced clinical characteristics. Silence of cell division cycle 45 suppressed proliferation of papillary thyroid cancer cells via G1-phase arrest and inducing apoptosis. The oncogenic activity of cell division cycle 45 was also confirmed in vivo. In conclusion, cell division cycle 45 may serve as a novel biomarker and a potential therapeutic target for papillary thyroid cancer.

Partnerships in global health and collaborative governance: lessons learnt from the Division of Tropical and Humanitarian Medicine at the Geneva University Hospitals.

PubMed

Beran, David; Aebischer Perone, Sigiriya; Alcoba, Gabriel; Bischoff, Alexandre; Bussien, Claire-Lise; Eperon, Gilles; Hagon, Olivier; Heller, Olivia; Jacquerioz Bausch, Frédérique; Perone, Nicolas; Vogel, Thomas; Chappuis, François

2016-04-29

In 2007 the "Crisp Report" on international partnerships increased interest in Northern countries on the way their links with Southern partners operated. Since its establishment in 2007 the Division of Tropical and Humanitarian Medicine at the Geneva University Hospitals has developed a variety of partnerships. Frameworks to assess these partnerships are needed and recent attention in the field of public management on collaborative governance may provide a useful approach for analyzing international collaborations. Projects of the Division of Tropical and Humanitarian Medicine were analyzed by collaborators within the Division using the model proposed by Emerson and colleagues for collaborative governance, which comprises different components that assess the collaborative process. International projects within the Division of Tropical and Humanitarian Medicine can be divided into four categories: Human resource development; Humanitarian response; Neglected Tropical Diseases and Noncommunicable diseases. For each of these projects there was a clear leader from the Division of Tropical and Humanitarian Medicine as well as a local counterpart. These individuals were seen as leaders both due to their role in establishing the collaboration as well as their technical expertise. Across these projects the actual partners vary greatly. This diversity means a wide range of contributions to the collaboration, but also complexity in managing different interests. A common definition of the collaborative aims in each of the projects is both a formal and informal process. Legal, financial and administrative aspects of the collaboration are the formal elements. These can be a challenge based on different administrative requirements. Friendship is part of the informal aspects and helps contribute to a relationship that is not exclusively professional. Using collaborative governance allows the complexity of managing partnerships to be presented. The framework used highlights the process of establishing collaborations, which is an element often negated by other more traditional models used in international partnerships. Applying the framework to the projects of the Division of Tropical and Humanitarian Medicine highlights the importance of shared values and interests, credibility of partners, formal and informal methods of management as well as friendship.

The Division of Household Labor: Longitudinal Changes and Within-Couple Variation

ERIC Educational Resources Information Center

Lam, Chun Bun; McHale, Susan M.; Crouter, Ann C.

2012-01-01

This study examined how the division of household labor changed as a function of marital duration and whether within-couple variation in spouses' relative power and availability were linked to within-couple variation in the division of labor. On 4 occasions over 7 years, 188 stably married couples reported on their housework activities using daily…

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

This eighth annual report of the Division covers work done during FY 1981 (October 1, 1980, through September 30, 1981). As with these documents in the past, the format follows approximately the organizational structure of the Energy Division. Chapters 2 through 6 summarize the activities of the sections of the Division: Environmental Impact Section, headed by H.E. Zittel; Regional and Urban Studies Section, R.M. Davis; Economic Analysis Section, R.B. Shelton; Data and Analysis Section, A.S. Loebl; and Efficiency and Renewables Research Section, J.W. Michel. In addition, work on a variety of projects which cut across section lines is reported inmore » Chapter 7, Integrated Programs. These activities are under the supervision of T.J. Wilbanks, Associate Director for the Division. Separate abstracts are included for individual projects.« less

The Astrophysics Science Division Annual Report 2008

NASA Technical Reports Server (NTRS)

Oegerle, William; Reddy, Francis; Tyler, Pat

2009-01-01

The Astrophysics Science Division (ASD) at Goddard Space Flight Center (GSFC) is one of the largest and most diverse astrophysical organizations in the world, with activities spanning a broad range of topics in theory, observation, and mission and technology development. Scientific research is carried out over the entire electromagnetic spectrum from gamma rays to radio wavelengths as well as particle physics and gravitational radiation. Members of ASD also provide the scientific operations for three orbiting astrophysics missions WMAP, RXTE, and Swift, as well as the Science Support Center for the Fermi Gamma-ray Space Telescope. A number of key technologies for future missions are also under development in the Division, including X-ray mirrors, and new detectors operating at gamma-ray, X-ray, ultraviolet, infrared, and radio wavelengths. This report includes the Division's activities during 2008.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

The body of this report provides summaries of the aims, scope and progress of the research by groups of investigators in the Division during the period of October 1, 1984, through September 30, 1985. At the end of each summary is a list of publications covering the same period. For convenience, the summaries are assembled under Sections in accordance with the current organizational structure of the Biology Division; each Section begins with an overview. It will be apparent, however, tha crosscurrents run throughout the Division and that the various programs support and interact with each other. In addition, this reportmore » includes information on the Division's educational activities, Advisory Committee, seminar program, and international interactions, as well as extramural activities of staff members, abstracts for technical meetings, and funding and personnel levels.« less

Receptor-mediated Drp1 oligomerization on endoplasmic reticulum

PubMed Central

Ji, Wei-Ke; Fan, Xintao; Strack, Stefan

2017-01-01

Drp1 is a dynamin guanosine triphosphatase important for mitochondrial and peroxisomal division. Drp1 oligomerization and mitochondrial recruitment are regulated by multiple factors, including interaction with mitochondrial receptors such as Mff, MiD49, MiD51, and Fis. In addition, both endoplasmic reticulum (ER) and actin filaments play positive roles in mitochondrial division, but mechanisms for their roles are poorly defined. Here, we find that a population of Drp1 oligomers is associated with ER in mammalian cells and is distinct from mitochondrial or peroxisomal Drp1 populations. Subpopulations of Mff and Fis1, which are tail-anchored proteins, also localize to ER. Drp1 oligomers assemble on ER, from which they can transfer to mitochondria. Suppression of Mff or inhibition of actin polymerization through the formin INF2 significantly reduces all Drp1 oligomer populations (mitochondrial, peroxisomal, and ER bound) and mitochondrial division, whereas Mff targeting to ER has a stimulatory effect on division. Our results suggest that ER can function as a platform for Drp1 oligomerization, and that ER-associated Drp1 contributes to mitochondrial division. PMID:29158231

Muscle Activation During Side-Step Cutting Maneuvers in Male and Female Soccer Athletes

PubMed Central

Hanson, Ashley M; Padua, Darin A; Troy Blackburn, J; Prentice, William E; Hirth, Christopher J

2008-01-01

Context: Female soccer athletes are at greater risk of anterior cruciate ligament (ACL) injury than males. Sex differences in muscle activation may contribute to the increased incidence of ACL injuries in female soccer athletes. Objective: To examine sex differences in lower extremity muscle activation between male and female soccer athletes at the National Collegiate Athletic Association Division I level during 2 side-step cutting maneuvers. Design: Cross-sectional with 1 between-subjects factor (sex) and 2 within-subjects factors (cutting task and phase of contact). Setting: Sports medicine research laboratory. Patients or Other Participants: Twenty males (age = 19.4 ± 1.4 years, height = 176.5 ± 5.5 cm, mass = 74.6 ± 6.0 kg) and 20 females (age = 19.8 ± 1.1 years, height = 165.7 ± 4.3 cm, mass = 62.2 ± 7.2 kg). Intervention(s): In a single testing session, participants performed the running-approach side-step cut and the box-jump side-step cut tasks. Main Outcome Measure(s): Surface electromyographic activity of the rectus femoris, vastus lateralis, medial hamstrings, lateral hamstrings, gluteus medius, and gluteus maximus was recorded for each subject. Separate mixed-model, repeated-measures analysis of variance tests were used to compare the dependent variables across sex during the preparatory and loading contact phases of each cutting task. Results: Females displayed greater vastus lateralis activity and quadriceps to hamstrings coactivation ratios during the preparatory and loading phases, as well as greater gluteus medius activation during the preparatory phase only. No significant differences were noted between the sexes for muscle activation in the other muscles analyzed during each task. Conclusions: The quadriceps-dominant muscle activation pattern observed in recreationally active females is also present in female soccer athletes at the Division I level when compared with similarly trained male soccer athletes. The relationship between increased quadriceps activation and greater incidence of noncontact ACL injury in female soccer athletes versus males requires further study. PMID:18345337

Visible-Light Resin Curing Units.

DTIC Science & Technology

1984-03-01

dental unit’s pilot or drive air pressure, and is activated via the foot control that also operates the high-speed and low-speed handpieces . For all...the Dental Investigation Sqtc* kvmtc)b Cini’cal Sciences Division, USAF School of Aerospace 114,~e Ameoae ~dical Division, APSC, Brooks Air force... Dental curing units White light activation II Visible-light activation 19. AISTRACT (Continue on ,werse if necenawy and identify by

A New Approach for the Design and Evaluation of Land Defense Concepts,

DTIC Science & Technology

1991-01-01

18. Theater-strategic situation in southern USSR, December 1942 ............. 84 19. 11th Panzer division’s activities in the Chir River battles...early December 1942 ................................................. 85 20. 11th Panzer division’s activities in the Chir River battles, mid-December...activity distributions in mind. Such reference values might come from historical studies (such as the Chir River example described below), map studies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

In 1988 the Atmospheric and Geophysical Sciences Division began its 15th year as a division. As the Division has grown over the years, its modeling capabilities have expanded to include a broad range of time and space scales ranging from hours to years, and from kilometers to global, respectively. For this report, we have chosen to show a subset of results from several projects to illustrate the breadth, depth, and diversity of the modeling activities that are a major part of the Division's research, development, and application efforts. In addition, the recent reorganization of the Division, including the merger ofmore » another group with the Division, is described, and the budget, personnel, models, and publications are reviewed. 95 refs., 26 figs., 2 tabs.« less

Activity and Accumulation of Cell Division-Promoting Phenolics in Tobacco Tissue Cultures 1

PubMed Central

Teutonico, Rita A.; Dudley, Matthew W.; Orr, John D.; Lynn, David G.; Binns, Andrew N.

1991-01-01

Dehydrodiconiferyl alcohol glucosides (DCGs) are derivatives of the phenylpropanoid pathway that have been isolated from Catharansus roseus L. (Vinca rosea) crown gall tumors. Fractions containing purified DCGs have been shown previously to promote the growth of cytokinin-requiring tissues of tobacco in the absence of exogenous cytokinins. In this study, we utilized synthetic DCG isomers to confirm the cell division-promoting activity of DCG isomers A and B and show that they neither promote shoot meristem initiation on Nicotiana tabacum L., cv Havana 425, leaf explants nor induce betacyanin synthesis in amaranth seedlings. Analysis of cultured tobacco pith tissue demonstrated that DCG accumulation was stimulated by cytokinin treatment and correlated with cytokinin-induced cell division. Thus, the accumulation of metabolites that could replace cytokinin in cell division bioassays is stimulated by cytokinins. These data support the model that DCGs are a component of a cytokinin-mediated regulatory circuit controlling cell division. ImagesFigure 2 PMID:16668384

Occludin Independently Regulates Permeability under Hydrostatic Pressure and Cell Division in Retinal Pigment Epithelial Cells

PubMed Central

Phillips, Brett E.; Cancel, Limary; Tarbell, John M.; Antonetti, David A.

2008-01-01

Purpose The aim of this study was to determine the function of the tight junction protein occludin in the control of permeability, under diffusive and hydrostatic pressures, and its contribution to the control of cell division in retinal pigment epithelium. Methods Occludin expression was inhibited in the human retinal pigment epithelial cell line ARPE-19 by siRNA. Depletion of occludin was confirmed by Western blot, confocal microscopy, and RT-PCR. Paracellular permeability of cell monolayers to fluorescently labeled 70 kDa dextran, 10 kDa dextran, and 467 Da tetramethylrhodamine (TAMRA) was examined under diffusive conditions or after the application of 10 cm H2O transmural pressure. Cell division rates were determined by tritiated thymidine incorporation and Ki67 immunoreactivity. Cell cycle inhibitors were used to determine whether changes in cell division affected permeability. Results Occludin depletion increased diffusive paracellular permeability to 467 Da TAMRA by 15%, and permeability under hydrostatic pressure was increased 50% compared with control. Conversely, depletion of occludin protein with siRNA did not alter diffusive permeability to 70 kDa and 10 kDa RITC-dextran, and permeability to 70 kDa dextran was twofold lower in occludin-depleted cells under hydrostatic pressure conditions. Occludin depletion also increased thymidine incorporation by 90% and Ki67-positive cells by 50%. Finally, cell cycle inhibitors did not alter the effect of occludin siRNA on paracellular permeability. Conclusions The data suggest that occludin regulates tight junction permeability in response to changes in hydrostatic pressure. Furthermore, these data suggest that occludin also contributes to the control of cell division, demonstrating a novel function for this tight junction protein. PMID:18263810

Intercellular Variability in Protein Levels from Stochastic Expression and Noisy Cell Cycle Processes

PubMed Central

Soltani, Mohammad; Vargas-Garcia, Cesar A.; Antunes, Duarte; Singh, Abhyudai

2016-01-01

Inside individual cells, expression of genes is inherently stochastic and manifests as cell-to-cell variability or noise in protein copy numbers. Since proteins half-lives can be comparable to the cell-cycle length, randomness in cell-division times generates additional intercellular variability in protein levels. Moreover, as many mRNA/protein species are expressed at low-copy numbers, errors incurred in partitioning of molecules between two daughter cells are significant. We derive analytical formulas for the total noise in protein levels when the cell-cycle duration follows a general class of probability distributions. Using a novel hybrid approach the total noise is decomposed into components arising from i) stochastic expression; ii) partitioning errors at the time of cell division and iii) random cell-division events. These formulas reveal that random cell-division times not only generate additional extrinsic noise, but also critically affect the mean protein copy numbers and intrinsic noise components. Counter intuitively, in some parameter regimes, noise in protein levels can decrease as cell-division times become more stochastic. Computations are extended to consider genome duplication, where transcription rate is increased at a random point in the cell cycle. We systematically investigate how the timing of genome duplication influences different protein noise components. Intriguingly, results show that noise contribution from stochastic expression is minimized at an optimal genome-duplication time. Our theoretical results motivate new experimental methods for decomposing protein noise levels from synchronized and asynchronized single-cell expression data. Characterizing the contributions of individual noise mechanisms will lead to precise estimates of gene expression parameters and techniques for altering stochasticity to change phenotype of individual cells. PMID:27536771

Women of the Solar Physics Division

NASA Astrophysics Data System (ADS)

Dupree, Andrea K.

2007-05-01

In 1970, when the Solar Physics Division was established, the invitation to become a founding member of the Division was extended by the Organizing Committee to a group of 61 solar scientists of which 4 were women (6.6%). At the first SPD meeting in Huntsville AL (1970), 11% of the papers were given by women. Near that time (1973), women accounted for 8% of all AAS members. The representation of women in the SPD has more than doubled in percentage since the first years. Currently, women comprise about 15.5% of SPD members which, however, is less than the percentage in the AAS general membership (18%) in March 2007. In the 37 years that the SPD has existed, women have frequently held the office of Treasurer and Secretary of the Division and made notable contributions. Elske V.P. Smith was elected the first Treasurer of the SPD and that began a long tradition. Women appear to be considered exceptionally trustworthy since they have been reelected and occupied the position of Treasurer for 75% of the available terms. The Office of SPD Secretary has seen a woman for 13% of the terms. Yet women are practically absent among those in the top leadership positions and in the lists of prize winners of the SPD. Among the 21 SPD Chairs, only 1 woman, Judith T. Karpen, has held that office. The Hale Prize has been awarded 19 times in almost 3 decades, and all of the awardees have been men. Several aspects of the participation of women and their contributions to the Solar Physics Division of the AAS will be reviewed, and compared to that of the AAS and astronomy in general.

Time to Stabilization of Anterior Cruciate Ligament–Reconstructed Versus Healthy Knees in National Collegiate Athletic Association Division I Female Athletes

PubMed Central

Webster, Kathryn A.; Gribble, Phillip A.

2010-01-01

Abstract Context: Jump landing is a common activity in collegiate activities, such as women's basketball, volleyball, and soccer, and is a common mechanism for anterior cruciate ligament (ACL) injury. It is important to better understand how athletes returning to competition after ACL reconstruction are able to maintain dynamic postural control during a jump landing. Objective: To use time to stabilization (TTS) to measure differences in dynamic postural control during jump landing in ACL-reconstructed (ACLR) knees compared with healthy knees among National Collegiate Athletic Association Division I female athletes. Design: Case-control study. Setting: University athletic training research laboratory. Patients or Other Participants: Twenty-four Division I female basketball, volleyball, and soccer players volunteered and were assigned to the healthy control group (n  =  12) or the ACLR knee group (n  =  12). Participants with ACLR knees were matched to participants with healthy knees by sport and by similar age, height, and mass. Intervention(s): At 1 session, participants performed a single-leg landing task for both limbs. They were instructed to stabilize as quickly as possible in a single-limb stance and remain as motionless as possible for 10 seconds. Main Outcome Measure(s): The anterior-posterior TTS and medial-lateral TTS ground reaction force data were used to calculate resultant vector of the TTS (RVTTS) during a jump landing. A 1-way analysis of variance was used to determine group differences on RVTTS. The means and SDs from the participants' 10 trials in each leg were used for the analyses. Results: The ACLR group (2.01 ± 0.15 seconds, 95% confidence interval [CI]  =  1.91, 2.10) took longer to stabilize than the control group (1.90 ± 0.07 seconds, 95% CI  =  1.86, 1.95) (F1,22  =  4.28, P  =  .05). This result was associated with a large effect size and a 95% CI that did not cross zero (Cohen d  =  1.0, 95% CI  =  0.91, 1.09). Conclusions: Although they were Division I female athletes at an average of 2.5 years after ACL reconstruction, participants with ACLR knees demonstrated dynamic postural-control deficits as evidenced by their difficulty in controlling ground reaction forces. This increased TTS measurement might contribute to the established literature reflecting differences in single-limb dynamic control. Clinicians might need to focus rehabilitation efforts on stabilization after jump landing. Further research is needed to determine if TTS is a contributing factor in future injury. PMID:21062181

Does NATO need a New Conventional Operational Strategy?

DTIC Science & Technology

1980-05-29

conducts an annual Defense Review to see how each nation is contributing to the Long Term Defense Program. 1 Steve Canby reminds us that the conventional...rather than add more divisions. The problem of how to guard the whole line of the Iron Curtain with such limited numbers of divisions was also discussed...at present . . . and some restationing; is needed.6 It is clear from the beginning of MkTO that forward defense was an important goal but how far

ADP Analysis project for the Human Resources Management Division

NASA Technical Reports Server (NTRS)

Tureman, Robert L., Jr.

1993-01-01

The ADP (Automated Data Processing) Analysis Project was conducted for the Human Resources Management Division (HRMD) of NASA's Langley Research Center. The three major areas of work in the project were computer support, automated inventory analysis, and an ADP study for the Division. The goal of the computer support work was to determine automation needs of Division personnel and help them solve computing problems. The goal of automated inventory analysis was to find a way to analyze installed software and usage on a Macintosh. Finally, the ADP functional systems study for the Division was designed to assess future HRMD needs concerning ADP organization and activities.

Aurora A kinase contributes to a pole-based error correction pathway

PubMed Central

Ye, Anna A.; Deretic, Jovana; Hoel, Christopher M.; Hinman, Albert W.; Cimini, Daniela; Welburn, Julie P.; Maresca, Thomas J.

2015-01-01

Summary Chromosome biorientation, where sister kinetochores attach to microtubules (MTs) from opposing spindle poles, is the configuration that best ensures equal partitioning of the genome during cell division. Erroneous kinetochore-microtubule (kt-MT) attachments are commonplace but often corrected prior to anaphase [1, 2]. Error correction, thought to be mediated primarily by the centromere-enriched Aurora B kinase (ABK) [3-5], typically occurs near spindle poles [6]; albeit, the relevance of this locale is unclear. Furthermore, polar ejection forces (PEFs), highest near poles [7], can stabilize improper attachments by pushing mal-oriented chromosome arms away from spindle poles [8, 9]. Hence, a conundrum: erroneous kt-MT attachments are weakened where PEFs are most likely to strengthen them. Here, we report that Aurora A kinase (AAK) opposes the stabilizing effect of PEFs. AAK activity contributes to phosphorylation of kinetochore substrates near poles and its inhibition results in chromosome mis-alignment and an increased incidence of erroneous kt-MT attachments. Furthermore, AAK directly phosphorylates a site in the N-terminal tail of Ndc80/Hec1 that has been implicated in reducing the affinity of the Ndc80 complex for MTs when phosphorylated [10-12]. We propose that an AAK activity gradient contributes to correcting mal-oriented kt-MT attachments in the vicinity of spindle poles. PMID:26166783

Suggestions for Teaching Mathematics Using Laboratory Approaches in Grades 1-3. 7. The Metric System.

ERIC Educational Resources Information Center

New York State Education Dept., Albany. Bureau of General Education Curriculum Development.

This guide is the seventh teachers' guide developed by the Division for Curricular Services and the Bureau of Mathematics Education in cooperation with the Division of Federal Education Opportunity Programs, ESEA Title I. It contains 100 mathematics activities within 37 pages for primary students. The activities are planned for teachers to use…

Seismology program; California Division of Mines and Geology

USGS Publications Warehouse

Sherburne, R. W.

1981-01-01

The year 1980 marked the centennial of the California Division of Mines and Geology (CDMG) and a decade of the Division's involvement in seismology. Factors which contributed to the formation of a Seismology Group within CDMG included increased concerns for environmental and earthquake safety, interest in earthquake prediction, the 1971 San Fernando earthquake and the 1973 publication by CDMG of an urban geology master plan for California. Reasons to be concerned about California's earthquake problem are demonstrated by the accompanying table and the figures. Recent seismicity in California, the Southern California uplift reflecting changes in crustal strain, and other possible earthquake precursors have heightened concern among scientific and governmental groups about the possible occurrence of a major damaging earthquake )M>7) in California. 

United States Army Medical Materiel Development Activity: 1997 Annual Report.

DTIC Science & Technology

1997-01-01

business planning and execution information management system (Project Management Division Database ( PMDD ) and Product Management Database System (PMDS...MANAGEMENT • Project Management Division Database ( PMDD ), Product Management Database System (PMDS), and Special Users Database System:The existing...System (FMS), were investigated. New Product Managers and Project Managers were added into PMDS and PMDD . A separate division, Support, was

The cell wall hydrolase Pmp23 is important for assembly and stability of the division ring in Streptococcus pneumoniae.

PubMed

Jacq, Maxime; Arthaud, Christopher; Manuse, Sylvie; Mercy, Chryslène; Bellard, Laure; Peters, Katharina; Gallet, Benoit; Galindo, Jennifer; Doan, Thierry; Vollmer, Waldemar; Brun, Yves V; VanNieuwenhze, Michael S; Di Guilmi, Anne Marie; Vernet, Thierry; Grangeasse, Christophe; Morlot, Cecile

2018-05-15

Bacterial division is intimately linked to synthesis and remodeling of the peptidoglycan, a cage-like polymer that surrounds the bacterial cell, providing shape and mechanical resistance. The bacterial division machinery, which is scaffolded by the cytoskeleton protein FtsZ, includes proteins with enzymatic, structural or regulatory functions. These proteins establish a complex network of transient functional and/or physical interactions which preserve cell shape and cell integrity. Cell wall hydrolases required for peptidoglycan remodeling are major contributors to this mechanism. Consistent with this, their deletion or depletion often results in morphological and/or division defects. However, the exact function of most of them remains elusive. In this work, we show that the putative lysozyme activity of the cell wall hydrolase Pmp23 is important for proper morphology and cell division in the opportunistic human pathogen Streptococcus pneumoniae. Our data indicate that active Pmp23 is required for proper localization of the Z-ring and the FtsZ-positioning protein MapZ. In addition, Pmp23 localizes to the division site and interacts directly with the essential peptidoglycan synthase PBP2x. Altogether, our data reveal a new regulatory function for peptidoglycan hydrolases.

The Arf GAP CNT-2 regulates the apoptotic fate in C. elegans asymmetric neuroblast divisions.

PubMed

Singhvi, Aakanksha; Teuliere, Jerome; Talavera, Karla; Cordes, Shaun; Ou, Guangshuo; Vale, Ronald D; Prasad, Brinda C; Clark, Scott G; Garriga, Gian

2011-06-07

During development, all cells make the decision to live or die. Although the molecular mechanisms that execute the apoptotic program are well defined, less is known about how cells decide whether to live or die. In C. elegans, this decision is linked to how cells divide asymmetrically [1, 2]. Several classes of molecules are known to regulate asymmetric cell divisions in metazoans, yet these molecules do not appear to control C. elegans divisions that produce apoptotic cells [3]. We identified CNT-2, an Arf GTPase-activating protein (GAP) of the AGAP family, as a novel regulator of this type of neuroblast division. Loss of CNT-2 alters daughter cell size and causes the apoptotic cell to adopt the fate of its sister cell, resulting in extra neurons. CNT-2's Arf GAP activity is essential for its function in these divisions. The N terminus of CNT-2, which contains a GTPase-like domain that defines the AGAP class of Arf GAPs, negatively regulates CNT-2's function. We provide evidence that CNT-2 regulates receptor-mediated endocytosis and consider the implications of its role in asymmetric cell divisions. Copyright © 2011 Elsevier Ltd. All rights reserved.

Functional redundancy of division specific penicillin-binding proteins in Bacillus subtilis.

PubMed

Sassine, Jad; Xu, Meizhu; Sidiq, Karzan R; Emmins, Robyn; Errington, Jeff; Daniel, Richard A

2017-10-01

Bacterial cell division involves the dynamic assembly of a diverse set of proteins that coordinate the invagination of the cell membrane and synthesis of cell wall material to create the new cell poles of the separated daughter cells. Penicillin-binding protein PBP 2B is a key cell division protein in Bacillus subtilis proposed to have a specific catalytic role in septal wall synthesis. Unexpectedly, we find that a catalytically inactive mutant of PBP 2B supports cell division, but in this background the normally dispensable PBP 3 becomes essential. Phenotypic analysis of pbpC mutants (encoding PBP 3) shows that PBP 2B has a crucial structural role in assembly of the division complex, independent of catalysis, and that its biochemical activity in septum formation can be provided by PBP 3. Bioinformatic analysis revealed a close sequence relationship between PBP 3 and Staphylococcus aureus PBP 2A, which is responsible for methicillin resistance. These findings suggest that mechanisms for rescuing cell division when the biochemical activity of PBP 2B is perturbed evolved prior to the clinical use of β-lactams. © 2017 The Authors. Molecular Microbiology published by John Wiley & Sons Ltd.

INTRINSIC NEURONAL PLASTICITY IN THE JUXTACAPSULAR NUCLEUS OF THE BED NUCLEI OF THE STRIA TERMINALIS (jcBNST)

PubMed Central

Francesconi, Walter; Berton, Fulvia; Koob, George F.; Sanna, Pietro Paolo

2010-01-01

The juxtacapsular nucleus of the anterior division of the BNST (jcBNST) receives robust glutamatergic projections from the basolateral nucleus of the amygdala (BLA), the postpiriform transition area, and the insular cortex as well as dopamine (DA) inputs from the midbrain. In turn the jcBNST sends GABAergic projections to the medial division of the central nucleus of the amygdala (CEAm) as well as other brain regions. We recently described a form of long-term potentiation of the intrinsic excitability (LTP-IE) of neurons of the juxtacapsular nucleus of BNST (jcBNST) in response to high-frequency stimulation (HFS) of the stria terminalis that was impaired during protracted withdrawal from alcohol, cocaine, and heroin and in rats chronically treated with corticotropin releasing factor (CRF) intracerebroventricularly. Here we show that DAergic neurotransmission is required for the induction of LTP-IE of jcBNTS neurons through dopamine (DA) D1 receptors. Thus, activation of the central CRF stress system and altered DAergic neurotransmission during protracted withdrawal from alcohol and drugs of abuse may contribute to the disruption of LTP-IE in the jcBNST. Impairment of this form of intrinsic neuronal plasticity in the jcBNST could result in inadequate neuronal integration and reduced inhibition of the CEA, contributing to the negative affective state that characterizes protracted abstinence in post-dependent individuals. These results provide a novel neurobiological target for vulnerability to alcohol and drug dependence. PMID:19683025

Chemical Engineering Division Activities

ERIC Educational Resources Information Center

Chemical Engineering Education, 1978

1978-01-01

The 1978 ASEE Chemical Engineering Division Lecturer was Theodore Vermeulen of the University of California at Berkeley. Other chemical engineers who received awards or special recognition at a recent ASEE annual conference are mentioned. (BB)

Contacts in the Office of Pesticide Programs, Biopesticides and Pollution Prevention Division

EPA Pesticide Factsheets

Contact the Biopesticides and Pollution Prevention Division (BPPD) about regulatory activities associated with biologically-based pesticides, implementation of integrated pest management and the Pesticide Environmental Stewardship Program.

Contacts in the Office of Pesticide Programs, Pesticide Re-Evaluation Division

EPA Pesticide Factsheets

Contact the Pesticide Re-Evaluation Division (PRD) about registration review and reregistration follow up (including post-RED activities, product reregistration, and implementing certain tolerance reassessment decisions) for conventional pesticides.

Lessons Learned, Headquarters, 2d Infantry Division

DTIC Science & Technology

responsibilities under the Armistice Agreement of 1953 in sector; (2) conduct anti-infiltration, anti-raiding, counter-espionage, and counter-sabotage activities; and (3) implement 2d Infantry Division portion of EUSA Cold War program.

MONTHLY HIGHLIGHTS (SUBSURFACE PROTECTION AND REMEDIATION DIVISION)

EPA Science Inventory

The Subsurface Protection and Remediation Division (SPRD) produces monthly highlights describing research accomplishments, involvement in current technical assistance activities, and staff participation in scientific meetings and conferences. Announcements of the release and avai...

Program report for FY 1984 and 1985 Atmospheric and Geophysical Sciences Division of the Physics Department

DOE Office of Scientific and Technical Information (OSTI.GOV)

Knox, J.B.; MacCracken, M.C.; Dickerson, M.H.

1986-08-01

This annual report for the Atmospheric and Geophysical Sciences Division (G-Division) summarizes the activities and highlights of the past three years, with emphasis on significant research findings in two major program areas: the Atmospheric Release Advisory Capability (ARAC), with its recent involvement in assessing the effects of the Chernobyl reactor accident, and new findings on the environmental consequences of nuclear war. The technical highlights of the many other research projects are also briefly reported, along with the Division's organization, budget, and publications.

Environmental Sciences Division annual progress report for period ending September 30, 1991

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1992-04-01

This progress report summarizes the research and development activities conducted in the Environmental Sciences Division of Oak Ridge National Laboratory during the period October 1, 1990, through September 30, 1991. The report is structured to provide descriptions of current activities and accomplishments in each of the division's major organizational units. Following the sections describing the organizational units is a section devoted to lists of information necessary to convey the scope of the work in the division. The Environmental Sciences Division (ESD) at Oak Ridge National Laboratory (ORNL) conducts environmental research and analyses associated with both energy technology development and themore » interactions between people and the environment. The division engages in basic and applied research for a diverse list of sponsors. While the US Department of Energy (DOE) is the primary sponsor ESD staff also perform research for other federal agencies, state agencies, and private industry. The division works collaboratively with federal agencies, universities, and private organizations in achieving its research objectives and hosts a large number of visiting investigators from these organizations. Given the diverse interdisciplinary specialization of its staff, ESD provides technical expertise on complex environmental problems and renders technical leadership for major environmental issues of national and local concern. This progress report highlights many of ESD's accomplishment in these and other areas in FY 1991.« less

Entheseal changes and sexual division of labor in a North-African population: The case of the pre-Hispanic period of the Gran Canaria Island (11th-15th c. CE).

PubMed

Santana-Cabrera, J; Velasco-Vázquez, J; Rodríguez-Rodríguez, A

2015-04-01

The aim of this paper is to investigate the relationship between entheseal changes and sexual division of labor in the pre-Hispanic population of Gran Canaria Island (Spain). Ethnohistorical records from the period of contact between Europeans and the Canarian indigenous population provide rich information about the different activities performed by men and women. For this purpose, entheseal changes in a sample of 138 individuals (82 males and 56 females) buried in ten pre-Hispanic cemeteries (11th and 15th centuries cal. CE) were analyzed. Forty-one entheses located in the clavicle, humerus, ulna and radius were analyzed (fibrous and fibro-cartilaginous attachment sites). Entheses were graded using a visual and descriptive standard which summarized the entheseal changes. This method interprets the changes as a sign of robustness on a scale from low to high development and includes enthesopathies. The intra- and inter-observer error of this method was minimal. Sex differences in the degree of robustness, bilateral asymmetry, sexual dimorphism and principal components analyses were tested in this sample. The results indicate significant variance in the entheseal robustness between males and females. They also suggest the impact of certain biomechanical chains (pronosupination, shoulder rotation, etc.) in entheseal changes. These results contribute to an interdisciplinary approach to the study of the sexual division of labor in the pre-Hispanic society of Gran Canaria. Copyright © 2015 Elsevier GmbH. All rights reserved.

Using "WeBWorK," a Web-Based Homework Delivery and Grading System, to Help Prepare Students for Active Learning

ERIC Educational Resources Information Center

Lucas, Adam R.

2012-01-01

"WeBWorK," an online homework system, can be be used to deliver daily reading questions to students. The author studied its use for this purpose with a lower division Introduction to Programming course and an upper division Probability and Statistics course. In the lower division course, "WeBWorK" significantly improved peer…

Calibration of hydrometers

NASA Astrophysics Data System (ADS)

Lorefice, Salvatore; Malengo, Andrea

2006-10-01

After a brief description of the different methods employed in periodic calibration of hydrometers used in most cases to measure the density of liquids in the range between 500 kg m-3 and 2000 kg m-3, particular emphasis is given to the multipoint procedure based on hydrostatic weighing, known as well as Cuckow's method. The features of the calibration apparatus and the procedure used at the INRiM (formerly IMGC-CNR) density laboratory have been considered to assess all relevant contributions involved in the calibration of different kinds of hydrometers. The uncertainty is strongly dependent on the kind of hydrometer; in particular, the results highlight the importance of the density of the reference buoyant liquid, the temperature of calibration and the skill of operator in the reading of the scale in the whole assessment of the uncertainty. It is also interesting to realize that for high-resolution hydrometers (division of 0.1 kg m-3), the uncertainty contribution of the density of the reference liquid is the main source of the total uncertainty, but its importance falls under about 50% for hydrometers with a division of 0.5 kg m-3 and becomes somewhat negligible for hydrometers with a division of 1 kg m-3, for which the reading uncertainty is the predominant part of the total uncertainty. At present the best INRiM result is obtained with commercially available hydrometers having a scale division of 0.1 kg m-3, for which the relative uncertainty is about 12 × 10-6.

Sandalwood: current interest and activity by the Hawaii Division of Forestry and Wildlife

Treesearch

Mark Scheffel

1990-01-01

The State of Hawaii Department of Land & Natural Resources (DLNR) protects native species growing on State land, but has no official program funding for growing sandalwood. Part of the DLNR, the Division of Forestry and Wildlife forest and nursery managers maintain exuberant activity in attempting to establish their nursery stock of sandalwood in the field out of...

[The Ethics and Deontology division of the French National Council of Medical Doctors, eight years of activity, 1993-2001].

PubMed

Hoerni, Bernard

2011-01-01

The activity of the division of Ethics and deontology of the French National council of medical doctors is analysed by its former president (1993-2001). Among a lot of topics, a new version of the professionnal Code of deontology and patients' information were the main subjects of reflection and action.

Investigating Quantum Mechanical Tunneling at the Nanoscale via Analogy: Development and Assessment of a Teaching Tool for Upper-Division Chemistry

ERIC Educational Resources Information Center

Muniz, Marc N.; Oliver-Hoyo, Maria T.

2014-01-01

We report a novel educational activity designed to teach quantum mechanical tunneling to upper-division undergraduate students in the context of nanochemistry. The activity is based on a theoretical framework for analogy and is split into three parts that are linked pedagogically through the framework: classical ball-and-ramp system, tunneling…

76 FR 39091 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-05

...: Betsy Metcalf, Enforcement Targeting & Data Division, Office of Compliance, 2222A, Environmental... agencies. Dated: June 28, 2011. Joseph A. Sierra, Acting Director, Collection Strategies Division. [FR Doc...

75 FR 82142 - Information Collection Activities

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-29

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket No... Foster, Standards and Rulemaking Division (PHH-12), Pipeline and Hazardous Materials Safety... Division (PHH-12), Pipeline and Hazardous Materials Safety Administration, 1200 New Jersey Avenue, SE...

Contacts in the Office of Pesticide Programs, Field and External Affairs Division

EPA Pesticide Factsheets

Contact the Field and External Affairs Division (FEAD) about program policies and regulations; legislation and congressional interaction; regional, state, and tribal coordination and assistance; international and field programs; and communication activity.

What Determines the Perception of Fairness Regarding Household Division of Labor between Spouses?

PubMed

Nakamura, Mayumi; Akiyoshi, Mito

2015-01-01

Married women often undertake a larger share of housework in many countries and yet they do not always perceive the inequitable division of household labor to be "unfair." Several theories have been proposed to explain the pervasive perception of fairness that is incongruent with the observed inequity in household tasks. These theories include 1) economic resource theory, 2) time constraint theory, 3) gender value theory, and 4) relative deprivation theory. This paper re-examines these theories with newly available data collected on Japanese married women in 2014 in order to achieve a new understanding of the gendered nature of housework. It finds that social comparison with others is a key mechanism that explains women's perception of fairness. The finding is compatible with relative deprivation theory. In addition to confirming the validity of the theory of relative deprivation, it further uncovers that a woman's reference groups tend to be people with similar life circumstances rather than non-specific others. The perceived fairness is also found to contribute to the sense of overall happiness. The significant contribution of this paper is to explicate how this seeming contradiction of inequity in the division of housework and the perception of fairness endures.

Control of the proportion of inner cells by asymmetric divisions and the ensuing resilience of cloned rabbit embryos

PubMed Central

Duranthon, Véronique

2018-01-01

ABSTRACT Mammalian embryo cloning by nuclear transfer has a low success rate. This is hypothesized to correlate with a high variability of early developmental steps that segregate outer cells, which are fated to extra-embryonic tissues, from inner cells, which give rise to the embryo proper. Exploring the cell lineage of wild-type embryos and clones, imaged in toto until hatching, highlights the respective contributions of cell proliferation, death and asymmetric divisions to phenotypic variability. Preferential cell death of inner cells in clones, probably pertaining to the epigenetic plasticity of the transferred nucleus, is identified as a major difference with effects on the proportion of inner cell. In wild type and clones, similar patterns of outer cell asymmetric divisions are shown to be essential to the robust proportion of inner cells observed in wild type. Asymmetric inner cell division, which is not described in mice, is identified as a regulator of the proportion of inner cells and likely gives rise to resilient clones. PMID:29567671

How autophagy eats large mitochondria: Autophagosome formation coupled with mitochondrial fragmentation.

PubMed

Yamashita, Shun-Ichi; Kanki, Tomotake

2017-05-04

Mitochondrial autophagy (mitophagy) is thought to be a multi-step pathway wherein mitochondria are first divided into small fragments, which are subsequently recognized by the phagophore. DNM1L (dynamin 1 like) plays a pivotal role in mitochondrial division; however, its role in mitophagy remains controversial. In our recent study, we examined the contribution of DNM1L to mitophagy and showed that mitophagy and mitochondrial division occur even in DNM1L-defective cells. Furthermore, time-lapse imaging of mitophagy showed that DNM1L-independent mitochondrial division occurs concomitantly with autophagosome formation. Upstream factors of autophagosome formation, i.e., RB1CC1/FIP200, ATG14, and WIPIs, are required for mitochondrial division, whereas ATG5 and ATG3 are dispensable. These results indicate that a portion of the tubular mitochondria is first recognized and then divided into small fragments by a phagophore-mediated event, independently of DNM1L. This autophagic process suggests that autophagy has the potential to degrade substrates larger than autophagosomes.

Workshop on Research for Space Exploration: Physical Sciences and Process Technology

NASA Technical Reports Server (NTRS)

Singh, Bhim S.

1998-01-01

This report summarizes the results of a workshop sponsored by the Microgravity Research Division of NASA to define contributions the microgravity research community can provide to advance the human exploration of space. Invited speakers and attendees participated in an exchange of ideas to identify issues of interest in physical sciences and process technologies. This workshop was part of a continuing effort to broaden the contribution of the microgravity research community toward achieving the goals of the space agency in human exploration, as identified in the NASA Human Exploration and Development of Space (HEDS) strategic plan. The Microgravity program is one of NASA'a major links to academic and industrial basic research in the physical and engineering sciences. At present, it supports close to 400 principal investigators, who represent many of the nation's leading researchers in the physical and engineering sciences and biotechnology. The intent of the workshop provided a dialogue between NASA and this large, influential research community, mission planners and industry technical experts with the goal of defining enabling research for the Human Exploration and Development of Space activities to which the microgravity research community can contribute.

Cytokinesis-Based Constraints on Polarized Cell Growth in Fission Yeast

PubMed Central

Bohnert, K. Adam; Gould, Kathleen L.

2012-01-01

The rod-shaped fission yeast Schizosaccharomyces pombe, which undergoes cycles of monopolar-to-bipolar tip growth, is an attractive organism for studying cell-cycle regulation of polarity establishment. While previous research has described factors mediating this process from interphase cell tips, we found that division site signaling also impacts the re-establishment of bipolar cell growth in the ensuing cell cycle. Complete loss or targeted disruption of the non-essential cytokinesis protein Fic1 at the division site, but not at interphase cell tips, resulted in many cells failing to grow at new ends created by cell division. This appeared due to faulty disassembly and abnormal persistence of the cell division machinery at new ends of fic1Δ cells. Moreover, additional mutants defective in the final stages of cytokinesis exhibited analogous growth polarity defects, supporting that robust completion of cell division contributes to new end-growth competency. To test this model, we genetically manipulated S. pombe cells to undergo new end take-off immediately after cell division. Intriguingly, such cells elongated constitutively at new ends unless cytokinesis was perturbed. Thus, cell division imposes constraints that partially override positive controls on growth. We posit that such constraints facilitate invasive fungal growth, as cytokinesis mutants displaying bipolar growth defects formed numerous pseudohyphae. Collectively, these data highlight a role for previous cell cycles in defining a cell's capacity to polarize at specific sites, and they additionally provide insight into how a unicellular yeast can transition into a quasi-multicellular state. PMID:23093943

The Arabidopsis minE mutation causes new plastid and FtsZ1 localization phenotypes in the leaf epidermis

PubMed Central

Fujiwara, Makoto T.; Kojo, Kei H.; Kazama, Yusuke; Sasaki, Shun; Abe, Tomoko; Itoh, Ryuuichi D.

2015-01-01

Plastids in the leaf epidermal cells of plants are regarded as immature chloroplasts that, like mesophyll chloroplasts, undergo binary fission. While mesophyll chloroplasts have generally been used to study plastid division, recent studies have suggested the presence of tissue- or plastid type-dependent regulation of plastid division. Here, we report the detailed morphology of plastids and their stromules, and the intraplastidic localization of the chloroplast division-related protein AtFtsZ1-1, in the leaf epidermis of an Arabidopsis mutant that harbors a mutation in the chloroplast division site determinant gene AtMinE1. In atminE1, the size and shape of epidermal plastids varied widely, which contrasts with the plastid phenotype observed in atminE1 mesophyll cells. In particular, atminE1 epidermal plastids occasionally displayed grape-like morphology, a novel phenotype induced by a plastid division mutation. Observation of an atminE1 transgenic line harboring an AtMinE1 promoter::AtMinE1-yellow fluorescent protein fusion gene confirmed the expression and plastidic localization of AtMinE1 in the leaf epidermis. Further examination revealed that constriction of plastids and stromules mediated by the FtsZ1 ring contributed to the plastid pleomorphism in the atminE1 epidermis. These results illustrate that a single plastid division mutation can have dramatic consequences for epidermal plastid morphology, thereby implying that plastid division and morphogenesis are differentially regulated in epidermal and mesophyll plastids. PMID:26500667

Strasburger's legacy to mitosis and cytokinesis and its relevance for the Cell Theory.

PubMed

Baluška, František; Volkmann, Dieter; Menzel, Diedrik; Barlow, Peter

2012-10-01

Eduard Strasburger was one of the most prominent biologists contributing to the development of the Cell Theory during the nineteenth century. His major contribution related to the characterization of mitosis and cytokinesis and especially to the discovery of the discrete stages of mitosis, which he termed prophase, metaphase and anaphase. Besides his observations on uninucleate plant and animal cells, he also investigated division processes in multinucleate cells. Here, he emphasised the independent nature of mitosis and cytokinesis. We discuss these issues from the perspective of new discoveries in the field of cell division and conclude that Strasburger's legacy will in the future lead to a reformulation of the Cell Theory and that this will accommodate the independent and primary nature of the nucleus, together with its complement of perinuclear microtubules, for the organisation of the eukaryotic cell.

[Progress in epidermal stem cells].

PubMed

Wang, Li-Juan; Wang, You-Liang; Yang, Xiao

2010-03-01

Mammalian skin epidermis contains different epidermal stem cell pools which contribute to the homeostasis and repair of skin epithelium. Epidermal stem cells possess two essential features common to all stem cells: self-renewal and differentiation. Disturbing the balance between self-renewal and differentiation of epidermal stem cell often causes tumors or other skin diseases. Epidermal stem cell niches provide a special microenvironment that maintains a balance of stem cell quiescence and activity. This review primarily concentrates on the following points of the epidermal stem cells: the existing evidences, the self-renewal and differentiation, the division pattern, the signal pathways regulating self-renewal and differentiation, and the microenvironment (niche) and macroenvironment maintaining the homeostasis of stem cells.

Analysis of cell division patterns in the Arabidopsis shoot apical meristem

DOE PAGES

Shapiro, Bruce E.; Tobin, Cory; Mjolsness, Eric; ...

2015-03-30

The stereotypic pattern of cell shapes in the Arabidopsis shoot apical meristem (SAM) suggests that strict rules govern the placement of new walls during cell division. When a cell in the SAM divides, a new wall is built that connects existing walls and divides the cytoplasm of the daughter cells. Because features that are determined by the placement of new walls such as cell size, shape, and number of neighbors are highly regular, rules must exist for maintaining such order. Here in this paper we present a quantitative model of these rules that incorporates different observed features of cell division.more » Each feature is incorporated into a "potential function" that contributes a single term to a total analog of potential energy. New cell walls are predicted to occur at locations where the potential function is minimized. Quantitative terms that represent the well-known historical rules of plant cell division, such as those given by Hofmeister, Errera, and Sachs are developed and evaluated against observed cell divisions in the epidermal layer (L1) of Arabidopsis thaliana SAM. The method is general enough to allow additional terms for nongeometric properties such as internal concentration gradients and mechanical tensile forces.« less

Analytical Chemistry Division annual progress report for period ending December 31, 1985

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shultz, W.D.

1986-05-01

Progress reports are presented for the four major sections of the division: analytical spectroscopy, radioactive materials laboratories, inorganic chemistry, and organic chemistry. A brief discussion of the division's role in the Laboratory's Environmental Restoration and Facilities Upgrade is given. Information about quality assurance and safety programs is presented, along with a tabulation of analyses rendered. Publications, oral presentations, professional activities, educational programs, and seminars are cited.

Mitochondrial Division Inhibitor 1 (mdivi-1) Protects Neurons against Excitotoxicity through the Modulation of Mitochondrial Function and Intracellular Ca2+ Signaling.

PubMed

Ruiz, Asier; Alberdi, Elena; Matute, Carlos

2018-01-01

Excessive dynamin related protein 1 (Drp1)-triggered mitochondrial fission contributes to apoptosis under pathological conditions and therefore it has emerged as a promising therapeutic target. Mitochondrial division inhibitor 1 (mdivi-1) inhibits Drp1-dependent mitochondrial fission and is neuroprotective in several models of brain ischemia and neurodegeneration. However, mdivi-1 also modulates mitochondrial function and oxidative stress independently of Drp1, and consequently the mechanisms through which it protects against neuronal injury are more complex than previously foreseen. In this study, we have analyzed the effects of mdivi-1 on mitochondrial dynamics, Ca 2+ signaling, mitochondrial bioenergetics and cell viability during neuronal excitotoxicity in vitro . Time-lapse fluorescence microscopy revealed that mdivi-1 blocked NMDA-induced mitochondrial fission but not that triggered by sustained AMPA receptor activation, showing that mdivi-1 inhibits excitotoxic mitochondrial fragmentation in a source specific manner. Similarly, mdivi-1 strongly reduced NMDA-triggered necrotic-like neuronal death and, to a lesser extent, AMPA-induced toxicity. Interestingly, neuroprotection provided by mdivi-1 against NMDA, but not AMPA, correlated with a reduction in cytosolic Ca 2+ ([Ca 2+ ] cyt ) overload and calpain activation indicating additional cytoprotective mechanisms. Indeed, mdivi-1 depolarized mitochondrial membrane and depleted ER Ca 2+ content, leading to attenuation of mitochondrial [Ca 2+ ] increase and enhancement of the integrated stress response (ISR) during NMDA receptor activation. Finally, lentiviral knockdown of Drp1 did not rescue NMDA-induced mitochondrial fission and toxicity, indicating that neuroprotective activity of mdivi-1 is Drp1-independent. Together, these results suggest that mdivi-1 induces a Drp1-independent protective phenotype that prevents predominantly NMDA receptor-mediated excitotoxicity through the modulation of mitochondrial function and intracellular Ca 2+ signaling.

Spatial Control of Gene Expression by miR319-Regulated TCP Transcription Factors in Leaf Development.

PubMed

Bresso, Edgardo G; Chorostecki, Uciel; Rodriguez, Ramiro E; Palatnik, Javier F; Schommer, Carla

2018-02-01

The characteristic leaf shapes we see in all plants are in good part the outcome of the combined action of several transcription factor networks that translate into cell division activity during the early development of the organ. We show here that wild-type leaves have distinct transcriptomic profiles in center and marginal regions. Certain transcripts are enriched in margins, including those of CINCINNATA -like TCPs ( TEOSINTE BRANCHED, CYCLOIDEA and PCF1/2 ) and members of the NGATHA and STYLISH gene families. We study in detail the contribution of microRNA319 (miR319)-regulated TCP transcription factors to the development of the center and marginal regions of Arabidopsis ( Arabidopsis thaliana ) leaves. We compare in molecular analyses the wild type, the tcp2 tcp4 mutant that has enlarged flat leaves, and the tcp2 tcp3 tcp4 tcp10 mutant with strongly crinkled leaves. The different leaf domains of the tcp mutants show changed expression patterns for many photosynthesis-related genes, indicating delayed differentiation, especially in the marginal parts of the organ. At the same time, we found an up-regulation of cyclin genes and other genes that are known to participate in cell division, specifically in the marginal regions of tcp2 tcp3 tcp4 tcp10 Using GUS reporter constructs, we confirmed extended mitotic activity in the tcp2 tcp3 tcp4 tcp10 leaf, which persisted in small defined foci in the margins when the mitotic activity had already ceased in wild-type leaves. Our results describe the role of miR319-regulated TCP transcription factors in the coordination of activities in different leaf domains during organ development. © 2018 American Society of Plant Biologists. All Rights Reserved.

Nano Let‑7b sensitization of eliminating esophageal cancer stem‑like cells is dependent on blockade of Wnt activation of symmetric division.

PubMed

Pang, Yamei; Liu, Jian; Li, Xiang; Zhang, Yiwen; Zhang, Boxiang; Zhang, Jing; Du, Ning; Xu, Chongwen; Liang, Rui; Ren, Hong; Tang, Shou-Ching; Sun, Xin

2017-10-01

The poor therapy response and poor prognosis of esophageal cancer has made it one of the most malignant carcinoma, and the complicated multidisciplinary treatment failed to achieve a long-term disease-free survival. To diagnose esophageal cancer at an earlier stage, and to improve the effect of anticancer therapy would improve the therapeutic efficacy. After retrospective analysis of the cancer samples of patients who received esophagectomy, we found the relevance between ratio of either ALDH1 or CD133-positive cancer stem cells and 2-year recurrence. Higher ratios of cancer stem cells indicated later clinical stages, and Wnt signaling activation was more frequent in later esophageal carcinoma. Further in bench studies, we explored the suppressive roles and the mechanisms involved in Let‑7 on self-renewal in ECA‑109 and ECA‑9706 esophageal cancer stem cells. Isolated cancer stem cells naturally divide symmetrically and are therapy resistant. Therapy of fluorouracil and docetaxel both enriched the stem cells, proving the resistant characteristics of cancer stem cells. Wnt activation stimulated more symmetric division of stem cells, resulting in self-renewal promotion, which could be blocked by Let‑7 overexpression. Furthermore, enforced Let‑7 sensitized the stem cells to chemotherapies in a Wnt pathway inhibition-dependent manner, contributing to Let‑7 sensitization of chemotherapeutic response. Wnt activation weakened the suppressive Let‑7b through the sponge functions of CCAT-1, forming the negative feedback loop of Let‑7b/Wnt/CCAT1. These results identified the crucial participation of stem cells in esophageal cancer occurrence and progression as the potent indicator, and also indicate the potential powerful agent of Let‑7 nano-particles in treatment of cancer.

CedA is a novel Escherichia coli protein that activates the cell division inhibited by chromosomal DNA over-replication.

PubMed

Katayama, T; Takata, M; Sekimizu, K

1997-11-01

We isolated and characterized a new gene related to the control of cell division regulation in Escherichia coli. At 30 degrees C, the dnaAcos mutant causes over-replication of the chromosome, and colony formation is inhibited. We found that, at this temperature, the dnaAcos cells form filaments; therefore, septum formation is inhibited. This inhibition was independent of SfiA, an inhibitor of the septum-forming protein, FtsZ. To identify factors involved in this pathway of inhibition, we isolated seven multicopy suppressors for the cold-sensitive phenotype of the dnaAcos mutant. One of these proved to be a previously unknown gene, which we named cedA. This gene encoded a 12 kDa protein and resided at 38.9min on the E. coli genome map. A multicopy supply of the cedA gene to the dnaAcos cells did not repress over-replication of the chromosome but did stimulate cell division of the host, the result being growth of cells with an abnormally elevated chromosomal copy number. Therefore, the expression level of the cedA gene seems to be important for inhibiting cell division of the dnaAcos mutant at 30 degrees C. We propose that over-replication of the chromosome activates a pathway for inhibiting cell division and that the cedA gene modulates this division control. In the dnaA+ background, cedA also seems to affect cell division.

Features and News: Professional Biological Societies and Environmental Problems

ERIC Educational Resources Information Center

Granholm, Nels H.

1973-01-01

Presents concrete suggestions regarding the role of individuals and groups within the Division of Invertebrate Zoology (DIZ) of the American Society of Zoologists (ASZ) regarding their contributions toward constructive environmental action. (Author/EB)

Unusual extraction treatment in Class II division 1 using C-orthodontic mini-implants.

PubMed

Chung, Kyu-Rhim; Cho, Jae-Hee; Kim, Seong-Hun; Kook, Yoon-Ah; Cozzani, Mauro

2007-01-01

This paper describes the treatment of a female patient, aged 23 years and 5 months, with a Class II division 1 malocclusion, who showed severe anterior protrusion and lower anterior crowding. Specially-designed orthodontic mini-implants were placed bilaterally in the interdental space between both the upper and the lower posterior teeth. Both lower first molars showed severe apical lesions. Therefore, the treatment plan consisted of extraction of both upper first premolars and lower first molars, en masse retraction of the upper six anterior teeth, lower anterior alignment, and protraction of all the lower molars. C-implants(R) were used as substitutes for maxillary posterior anchorage teeth during anterior retraction and as hooks for mandibular molar protraction. The correct overbite and overjet were obtained by intruding and retracting the upper six anterior teeth into their proper positions. The dentition was detailed using conventional orthodontic appliances. The upper C-implants contributed to an improvement in facial balance, and the lower C-implants made it possible to protract the lower second and third molars with less effect on the axis of the lower anterior teeth. The active treatment period was 29 months and the patient's teeth continued to be stable 11 months after debonding.

A possible role of actin in the mechanical control of the cell cycle.

PubMed

Tripathi, S C

1989-01-01

Sail-sheet Cultures (SSC) are those in which the cells are i) grown within the meshes of inert grids ii) exposed to nutrients from most sides iii) attached to one another only at the edges like sail of a yacht (hence, the name 'sail-sheet') and iv) have the advantage of three-dimensional structure similar to an in vivo situation. We grew fibroblasts from chicken heart explants as SSC and studied the effect of mechanical stretching on the F-actin content of these cells. This study was designed to investigate the hypothesis that the effect of tension on the cell cycle may be channeled through the microfilaments. Data from this preliminary study suggested that short-term mechanical stretching of sail-sheets, using low frequency tension (1.0 Hz), diminishes F-actin. Thus, it may be possible to relate the decrease in the F-actin content of these cells to the slowing down of their locomotory activity, possible rounding up, and division. This study might contribute to the understanding of the mechanical control of the cell cycle and be of relevance in the phenomena such as healing of wounds and control of the cell division in tumors.

Wavelength-stepped, actively mode-locked fiber laser based on wavelength-division-multiplexed optical delay lines

NASA Astrophysics Data System (ADS)

Lee, Eunjoo; Kim, Byoung Yoon

2017-12-01

We propose a new scheme for an actively mode-locked wavelength-swept fiber laser that produces a train of discretely wavelength-stepped pulses from a short fiber cavity. Pulses with different wavelengths are split and combined by standard wavelength division multiplexers with fiber delay lines. As a proof of concept, we demonstrate a laser using an erbium doped fiber amplifier and commercially available wavelength-division multiplexers with wavelength spacing of 0.8 nm. The results show simultaneous mode-locking at three different wavelengths. Laser output parameters in time domain, optical and radio frequency spectral domain, and the noise characteristics are presented. Suggestions for the improved design are discussed.

Exploration: Past and Future Contributions of the Vertical Lift Community and the Flight Vehicle Research and Technology Division

NASA Technical Reports Server (NTRS)

Young, Larry A.; Aiken, Edwin W.

2005-01-01

Fulfillment of the exploration vision will require new cross-mission directorate and multi-technical discipline synergies in order to achieve the necessary long-term sustainability. In part, lessons from the Apollo-era, as well as more recent research efforts, suggest that the aeronautics and specifically the vertical lift research community can and will make significant contributions to the exploration effort. A number of notional concepts and associated technologies for such contributions are outlined.

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Malaise Turns into Determination

ERIC Educational Resources Information Center

American Vocational Journal, 1976

1976-01-01

Activities of the Home Economics Division at the American Vocational Association's 1975 Convention are summarized; addressed were the field's identity and image crises engendered by women's liberation and male chauvinism, and threats to significant Federal legislation in divisiveness, consequent exclusion from vocational education definitions, and…

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The poorest first: WHO's activities to help the people in greatest need.

PubMed

Jancloes, M

1998-01-01

Through its Division of Intensified Cooperation with Countries and Peoples in Greatest Need, WHO is giving special attention to the relationship between poverty and ill-health. The work of the Division is outlined in the present article.

Instrumentation and Controls Division progress report for the period July 1, 1986 to June 30, 1988

DOE Office of Scientific and Technical Information (OSTI.GOV)

Klobe, L.E.

1988-12-01

The Instrumentation and Controls (IandC) Division of Oak Ridge National Laboratory (ORNL) performs basic and applied instrumentation and controls research, development and design engineering, specialized instrument design and fabrication, and maintenance services for instruments, electronics, and computers. The IandC Division is one of the largest RandD organizations of its type among government laboratories, and it exists as the result of an organizational strategy to integrate ORNL's instrumentation and controls-related disciplines into one dedicated functional organization to increase the Laboratory's expertise and capabilities in these rapidly expanding, innovative areas of technology. The Division participates in the programs and projects of ORNLmore » by applying its expertise and capabilities in concert with other divisions to perform basic research and mission-oriented technology development. Many of the Division's RandD tasks that are a part of a larger ORNL program are of sufficient scope that the IandC effort constitutes a separate program element with direct funding and management responsibility within the Division. The activities of IandC include performance of an RandD task in IandC facilities, the participation of from one of many IandC engineers and scientists in a multidisciplinary team working in a specific research area or development project, design and fabrication of a special instrument or instrumentation system, or a few hours of maintenance service. In its support and maintenance work, the role of the IandC Division is to provide a level of expertise appropriate to complete a job successfully at minimum overall cost and time schedule---a role which involves IandC in almost all ORNL activities.« less

IFLA General Conference 1991. Division of Regional Activities: Section of Africa; Section of Asia and Oceania; Section of Latin America and the Carribean. Booklet 8.

ERIC Educational Resources Information Center

International Federation of Library Associations and Institutions, The Hague (Netherlands).

The six papers in this collection were presented at three sections of the Division of Regional Activities: (1) "A la recherche d'Approches adaptees aux Besoins en Documentation des Africains (In Search of an Approach Adapted to the Information Needs of Africans)" (Touria Temsamani Haji, Morocco); (2) "People's Libraries: An African…

A Process of Amplification of the Contributions of the Interfaith Ministry in the Student Affairs Division of Union College

ERIC Educational Resources Information Center

Brooks, Victoria J.

2009-01-01

This project examines the contributions of Interfaith Ministry to Union College with the hope of amplifying, or "turning up the volume" of this work in this ministry setting. Grounded in the historical realities of a small liberal arts college, the work explores models of chaplaincy in higher education on this specific campus and beyond.…

Phenotypes Associated with the Essential Diadenylate Cyclase CdaA and Its Potential Regulator CdaR in the Human Pathogen Listeria monocytogenes

PubMed Central

Rismondo, Jeanine; Gibhardt, Johannes; Rosenberg, Jonathan; Kaever, Volkhard

2015-01-01

ABSTRACT Cyclic diadenylate monophosphate (c-di-AMP) is a second messenger utilized by diverse bacteria. In many species, including the Gram-positive human pathogen Listeria monocytogenes, c-di-AMP is essential for growth. Here we show that the single diadenylate cyclase of L. monocytogenes, CdaA, is an integral membrane protein that interacts with its potential regulatory protein, CdaR, via the transmembrane protein domain. The presence of the CdaR protein is not required for the membrane localization and abundance of CdaA. We have also found that CdaR negatively influences CdaA activity in L. monocytogenes and that the role of CdaR is most evident at a high growth temperature. Interestingly, a cdaR mutant strain is less susceptible to lysozyme. Moreover, CdaA contributes to cell division, and cells depleted of CdaA are prone to lysis. The observation that the growth defect of a CdaA depletion strain can be partially restored by increasing the osmolarity of the growth medium suggests that c-di-AMP is important for maintaining the integrity of the protective cell envelope. Overall, this work provides new insights into the relationship between CdaA and CdaR. IMPORTANCE Cyclic diadenylate monophosphate (c-di-AMP) is a recently identified second messenger that is utilized by the Gram-positive human pathogen Listeria monocytogenes. Here we show that the single diadenylate cyclase of L. monocytogenes, CdaA, is an integral membrane protein that interacts with CdaR, its potential regulatory protein. We show that CdaR is not required for membrane localization or abundance of the diadenylate cyclase, but modulates its activity. Moreover, CdaA seems to contribute to cell division. Overall, this work provides new insights into the relationship between CdaA and CdaR and their involvement in cell growth. PMID:26527648

Mapping individuals' earthquake preparedness in China

NASA Astrophysics Data System (ADS)

Wu, Guochun; Han, Ziqiang; Xu, Weijin; Gong, Yue

2018-05-01

Disaster preparedness is critical for reducing potential impact. This paper contributes to current knowledge of disaster preparedness using representative national sample data from China, which faces high earthquake risks in many areas of the country. The adoption of earthquake preparedness activities by the general public, including five indicators of material preparedness and five indicators of awareness preparedness, were surveyed and 3245 respondents from all 31 provinces of Mainland China participated in the survey. Linear regression models and logit regression models were used to analyze the effects of potential influencing factors. Overall, the preparedness levels are not satisfied, with a material preparation score of 3.02 (1-5), and awareness preparation score of 2.79 (1-5), nationally. Meanwhile, residents from western China, which has higher earthquake risk, have higher degrees of preparedness. The concern for disaster risk reduction (DRR) and the concern for building safety and participation in public affairs are consistent positive predictors of both material and awareness preparedness. The demographic and socioeconomic variables' effects, such as gender, age, education, income, urban/rural division, and building size, vary according to different preparedness activities. Finally, the paper concludes with a discussion of the theoretical contribution and potential implementation.

Alternative Ways to Think about Cellular Internal Ribosome Entry*

PubMed Central

Gilbert, Wendy V.

2010-01-01

Internal ribosome entry sites (IRESs) are specialized mRNA elements that allow recruitment of eukaryotic ribosomes to naturally uncapped mRNAs or to capped mRNAs under conditions in which cap-dependent translation is inhibited. Putative cellular IRESs have been proposed to play crucial roles in stress responses, development, apoptosis, cell cycle control, and neuronal function. However, most of the evidence for cellular IRES activity rests on bicistronic reporter assays, the reliability of which has been questioned. Here, the mechanisms underlying cap-independent translation of cellular mRNAs and the contributions of such translation to cellular protein synthesis are discussed. I suggest that the division of cellular mRNAs into mutually exclusive categories of “cap-dependent” and “IRES-dependent” should be reconsidered and that the implications of cellular IRES activity need to be incorporated into our models of cap-dependent initiation. PMID:20576611

3rd Annual NASA Ames Space Science and Astrobiology Jamboree

NASA Technical Reports Server (NTRS)

Dotson, Jessie

2015-01-01

The Space Science and Astrobiology Division at NASA Ames Research Center consists of over 50 civil servants and more than 110 contractors, co-­-ops, post-­-docs and associates. Researchers in the division are pursuing investigations in a variety of fields including exoplanets, planetary science, astrobiology and astrophysics. In addition, division personnel support a wide variety of NASA missions including (but not limited to) Kepler, SOFIA, LADEE, JWST, and New Horizons. With such a wide variety of interesting research going on, distributed among three branches in at least 5 different buildings, it can be difficult to stay abreast of what one's fellow researchers are doing. Our goal in organizing this symposium is to facilitate communication and collaboration among the scientists within the division, and to give center management and other ARC researchers and engineers an opportunity to see what scientific research and science mission work is being done in the division. We are also continuing the tradition within the Space Science and Astrobiology Division to honor one senior and one early career scientist with the Pollack Lecture and the Early Career Lecture, respectively. With the Pollack Lecture, our intent is to select a senior researcher who has made significant contributions to any area of research within the space sciences, and we are pleased to honor Dr. William Borucki this year. With the Early Career Lecture, our intent is to select a young researcher within the division who, by their published scientific papers, shows great promise for the future in any area of space science research, and we are pleased to honor Dr. Melinda Kahre this year

Transcription and ncRNAs: at the cent(rome)re of kinetochore assembly and maintenance.

PubMed

Scott, Kristin C

2013-12-01

Centromeres are sites of chromosomal spindle attachment during mitosis and meiosis. Centromeres are defined, in part, by a distinct chromatin landscape in which histone H3 is replaced by the conserved histone H3 variant, CENP-A. Sequences competent for centromere formation and function vary among organisms and are typically composed of repetitive DNA. It is unclear how such diverse genomic signals are integrated with the epigenetic mechanisms that govern CENP-A incorporation at a single locus on each chromosome. Recent work highlights the intriguing possibility that the transcriptional properties of centromeric core DNA contribute to centromere identity and maintenance through cell division. Moreover, core-derived noncoding RNAs (ncRNAs) have emerged as active participants in the regulation and control of centromere activity in plants and mammals. This paper reviews the transcriptional properties of eukaryotic centromeres and discusses the known roles of core-derived ncRNAs in chromatin integrity, kinetochore assembly, and centromere activity.

76 FR 11513 - Agency Information Collection Activities; Existing Collection; Comments Requested

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76 FR 8775 - Agency Information Collection Activities: Proposed Collection; Comments Requested: Drug...

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2011-02-15

..., Human Resources Division, Drug Enforcement Administration, 8701 Morrissette Drive, Springfield, VA 22152... Administrator, Human Resources Division, Drug Enforcement Administration, 8701 Morrissette Drive, Springfield... Administration (DEA) will be submitting the following information collection request to the Office of Management...

Division of Labor in Colonies of the Eusocial Wasp, Mischocyttarus consimilis

PubMed Central

Torres, Viviana O.; Montagna, Thiago S.; Raizer, Josué; Antonialli-Junior, William F.

2012-01-01

The division of labor between castes and the division of labor in workers according to age (temporal polyethism) in social wasps are crucial for maintaining social organization. This study evaluated the division of labor between castes, and the temporal polyethism in workers of Mischocyttarus consimilis Zikán (Hymenoptera: Vespidae). To describe the behavioral repertory of this species, observations were made of 21 colonies, with 100 hours of observations. In order to observe temporal polyethism, each newly emerged wasp was marked with colored dots on the upper area of the thorax. This allowed the observation of behavioral acts performed by each worker from the time of emergence to its death. Through hybrid multidimensional scaling, a clear division between queens and workers could be identified, in which the behaviors of physical dominance and food solicitation characterized the queen caste; while behaviors such as adult—adult trophallaxis, destruction of cells, alarm, foraging for prey, foraging for nectar, and unsuccessful foraging characterized the worker caste. Hybrid multidimensional scaling characterized two groups, with intra—nest activities preferentially accomplished by younger workers, while extra—nest activities such as foraging were executed more frequently by older workers. PMID:22954231

Instrumentation and Controls Division Progress Report for the Period of July 1, 1994 to December 31, 1997: Publications, Presentations, Activities, and Awards

DOE Office of Scientific and Technical Information (OSTI.GOV)

McDonald, D.W.

This report contains a record of publishing and other activities in the Oak Ridge National Laboratory (ORNL) Instrumentation and Controls (I&C) Division for the period of July 1, 1994, to December31, 1997. It is a companion volume to Working Together on New Horizons: Instrumentation and Controls Division Progress Report for the Period of July 1, 1994, to December 31, 1997 (OR.NLA4-6530). Working Together on New Horizons contains illustrated summaries of some of the projects under way in I&C Division. Both books can be obtained by contacting C. R. Brittain (brittain@ornl. gov), P.O. Box 2008, Oak Ridge, TN 37831-6005. l&C Divisionmore » Mission and Vision I&C Division develops and maintains techniques, instruments, and systems that lead to a better understanding of nature and harnessing of natural phenomena for the benefit of humankind. We have dedicated ourselves to accelerating the advancement of science and the transfer of those advancements into products and processes that benefit U.S. industry and enhance the security of our citizens.« less

Physics division annual report 2006.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Glover, J.; Physics

2008-02-28

This report highlights the activities of the Physics Division of Argonne National Laboratory in 2006. The Division's programs include the operation as a national user facility of ATLAS, the Argonne Tandem Linear Accelerator System, research in nuclear structure and reactions, nuclear astrophysics, nuclear theory, investigations in medium-energy nuclear physics as well as research and development in accelerator technology. The mission of nuclear physics is to understand the origin, evolution and structure of baryonic matter in the universe--the core of matter, the fuel of stars, and the basic constituent of life itself. The Division's research focuses on innovative new ways tomore » address this mission.« less

What Determines the Perception of Fairness Regarding Household Division of Labor between Spouses?

PubMed Central

2015-01-01

Married women often undertake a larger share of housework in many countries and yet they do not always perceive the inequitable division of household labor to be “unfair.” Several theories have been proposed to explain the pervasive perception of fairness that is incongruent with the observed inequity in household tasks. These theories include 1) economic resource theory, 2) time constraint theory, 3) gender value theory, and 4) relative deprivation theory. This paper re-examines these theories with newly available data collected on Japanese married women in 2014 in order to achieve a new understanding of the gendered nature of housework. It finds that social comparison with others is a key mechanism that explains women’s perception of fairness. The finding is compatible with relative deprivation theory. In addition to confirming the validity of the theory of relative deprivation, it further uncovers that a woman’s reference groups tend to be people with similar life circumstances rather than non-specific others. The perceived fairness is also found to contribute to the sense of overall happiness. The significant contribution of this paper is to explicate how this seeming contradiction of inequity in the division of housework and the perception of fairness endures. PMID:26147921

PREFACE: 14th General Conference of the Condensed Matter Division

NASA Astrophysics Data System (ADS)

de Segovia, José L.; Flores, F.; García-Moliner, F.

1994-01-01

This volume contains the proceedings of the 14th General Conference of the Condensed Matter Division, GCCMD-14, held on 28-31 March 1994, at the Faculty of Civil Engineering of the Polytechnical University of Madrid. The publication contains the Plenary and Invited Lectures of those authors who agreed to publish their presentations. The meeting was organized by the Spanish Vacuum Society, ASEVA, under the auspices of the Condensed Matter Division of the European Physical Society, CMD-EPS. The Conference was attended by 466 participants mostly from Europe. The emphasis of the Conference was mainly on: Semiconductors and Insulators Surfaces and Interfaces Liquids and Statistical Mechanics Magnetism and Metals Macromolecules and Chemical Physics The 554 contributions were presented as 6 plenary lectures, 67 invited lectures, 140 oral presentation and 341 poster presentation, in five parallel sessions. The guest Editors are grateful to those authors who sent their contribution for the publication, to the Organizing Committee, to the International Advisory and Programme Committee and to the Local Committee for their excellent work. We also wish to thank those colleagues who took on the hard task of helping in refereeing the papers. It is also a pleasure to thank the Physica Scripta Editor and Editorial Board of Physica Scripta.

Converging social classes through humanized urban edges

NASA Astrophysics Data System (ADS)

Abuan, M. V.; Galingan, Z. D.

2017-10-01

Urban open spaces are created to be used by people. It is a place of convergence and social activity. However, these places have transformed into places of divergence. When spaces become dehumanized, it separates social classes. As a result, underused spaces contribute to urban decay. Particularly an urban edge, the JP Rizal Makati Waterfront Area is the center of this paper. The JP Rizal Makati Waterfront Area is a waterfront development situated along the banks of one of Metro Manila’s major water thoroughfare --- Pasig River. The park and its physical form, urban design and landscape tend to deteriorate over time --- creating a further division of social convergence. Social hostility, crime, negligent maintenance and poor urban design are contributing factors to this sprawling decay in what used to be spaces of bringing people together. Amidst attempts to beautify and renew this portion of Makati City’s edge, the urban area still remains misspent.This paper attempts to re-humanize the waterfront development. It uses the responsive environment design principles to be able to achieve this goal.

Contributorship and division of labor in knowledge production.

PubMed

Larivière, Vincent; Desrochers, Nadine; Macaluso, Benoît; Mongeon, Philippe; Paul-Hus, Adèle; Sugimoto, Cassidy R

2016-06-01

Scientific authorship has been increasingly complemented with contributorship statements. While such statements are said to ensure more equitable credit and responsibility attribution, they also provide an opportunity to examine the roles and functions that authors play in the construction of knowledge and the relationship between these roles and authorship order. Drawing on a comprehensive and multidisciplinary dataset of 87,002 documents in which contributorship statements are found, this article examines the forms that division of labor takes across disciplines, the relationships between various types of contributions, as well as the relationships between the contribution types and various indicators of authors' seniority. It shows that scientific work is more highly divided in medical disciplines than in mathematics, physics, and disciplines of the social sciences, and that, with the exception of medicine, the writing of the paper is the task most often associated with authorship. The results suggest a clear distinction between contributions that could be labeled as 'technical' and those that could be considered 'conceptual': While conceptual tasks are typically associated with authors with higher seniority, technical tasks are more often performed by younger scholars. Finally, results provide evidence of a U-shaped relationship between extent of contribution and author order: In all disciplines, first and last authors typically contribute to more tasks than middle authors. The paper concludes with a discussion of the implications of the results for the reward system of science.

76 FR 56766 - Agency Information Collection Activities: Proposed Collection; Comment Request

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RESEARCH AND TECHNOLOGY DIVISION REPORT FOR 1966.

ERIC Educational Resources Information Center

BAUM, C.

THE WORK OF THE RESEARCH AND TECHNOLOGY DIVISION OF SYSTEM DEVELOPMENT CORPORATION DURING 1966 IS REPORTED. THE PROGRESS OF VARIOUS STUDIES AND ACTIVITIES DISCUSSED IN THE REPORT WERE ADVANCED PROGRAMING, INFORMATION PROCESSING RESEARCH, PROGRAMING SYSTEMS, DATA BASE SYSTEMS. LANGUAGE PROCESSING AND RETRIEVAL, BEHAVIORAL GAMING AND SIMULATION…

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34 CFR 421.3 - What activities may the Secretary fund?

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2011-07-01

... VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION BUSINESS AND EDUCATION STANDARDS PROGRAM General... for projects that organize and operate business-labor-education technical committees that propose... in those divisions or specialty areas; (c) Minimum tools and equipment required in those divisions or...

34 CFR 421.3 - What activities may the Secretary fund?

Code of Federal Regulations, 2010 CFR

2010-07-01

... VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION BUSINESS AND EDUCATION STANDARDS PROGRAM General... for projects that organize and operate business-labor-education technical committees that propose... in those divisions or specialty areas; (c) Minimum tools and equipment required in those divisions or...

Day-night cycles and the sleep-promoting factor, Sleepless, affect stem cell activity in the Drosophila testis.

PubMed

Tulina, Natalia M; Chen, Wen-Feng; Chen, Jung Hsuan; Sowcik, Mallory; Sehgal, Amita

2014-02-25

Adult stem cells maintain tissue integrity and function by renewing cellular content of the organism through regulated mitotic divisions. Previous studies showed that stem cell activity is affected by local, systemic, and environmental cues. Here, we explore a role of environmental day-night cycles in modulating cell cycle progression in populations of adult stem cells. Using a classic stem cell system, the Drosophila spermatogonial stem cell niche, we reveal daily rhythms in division frequencies of germ-line and somatic stem cells that act cooperatively to produce male gametes. We also examine whether behavioral sleep-wake cycles, which are driven by the environmental day-night cycles, regulate stem cell function. We find that flies lacking the sleep-promoting factor Sleepless, which maintains normal sleep in Drosophila, have increased germ-line stem cell (GSC) division rates, and this effect is mediated, in part, through a GABAergic signaling pathway. We suggest that alterations in sleep can influence the daily dynamics of GSC divisions.

The Yeast Cyclin-Dependent Kinase Routes Carbon Fluxes to Fuel Cell Cycle Progression.

PubMed

Ewald, Jennifer C; Kuehne, Andreas; Zamboni, Nicola; Skotheim, Jan M

2016-05-19

Cell division entails a sequence of processes whose specific demands for biosynthetic precursors and energy place dynamic requirements on metabolism. However, little is known about how metabolic fluxes are coordinated with the cell division cycle. Here, we examine budding yeast to show that more than half of all measured metabolites change significantly through the cell division cycle. Cell cycle-dependent changes in central carbon metabolism are controlled by the cyclin-dependent kinase (Cdk1), a major cell cycle regulator, and the metabolic regulator protein kinase A. At the G1/S transition, Cdk1 phosphorylates and activates the enzyme Nth1, which funnels the storage carbohydrate trehalose into central carbon metabolism. Trehalose utilization fuels anabolic processes required to reliably complete cell division. Thus, the cell cycle entrains carbon metabolism to fuel biosynthesis. Because the oscillation of Cdk activity is a conserved feature of the eukaryotic cell cycle, we anticipate its frequent use in dynamically regulating metabolism for efficient proliferation. Copyright © 2016 Elsevier Inc. All rights reserved.

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[Sanitary and epidemiological conditions in the Lodz region during the period of the second Polish Republic in the XIX and XX centuries].

PubMed

Sadowska, Jolanta

2005-01-01

Throughout history of European agglomerations in the nineteenth and twentieth century the relation between expanding industry and worsening sanitary and epidemiological conditions was seen. These changes, having great impact on public health, were investigated in the present study. Problems related to sanitary and epidemiological conditions in Lodz first emerged during the Russian occupation of Poland in the XIX century. The Russian Governing Council was not overseeing sanitary conditions of the city, and transferred this responsibility to the industrial bourgeoisie of Lodz. In this situation, uncontrolled development of the industry led to serious deterioration in natural environment and increase of risk for acute and chronic infectious diseases. Improvement of the sanitary situation in Lodz commenced in the period of the Second Polish Republic (1918-1939). Sanitary Divisions were created at the Lodz Department of Public Health. Activities in this Department involved, among others, detailed epidemiological examination of potable water, the investigation of manufacturing processes, retail and wholesale groceries, hygienic conditions of public housing. The activity and interventions of Sanitary Divisions contributed substantially to a decrease of incidence of various diseases and improvement of living conditions of the Lodz populations. The improvement of sanitary and epidemiological conditions in Lodz after 1918 was mainly related to the construction of water supply and sewage systems. This led to an approximation of the urban standards of this 500,000 population agglomeration to European standards.

Substrate-specific regulation of ubiquitination by the anaphase-promoting complex

PubMed Central

Song, Ling

2011-01-01

By orchestrating the sequential degradation of a large number of cell cycle regulators, the ubiquitin ligase anaphase-promoting complex (APC/C) is essential for proliferation in all eukaryotes. The correct timing of APC/C-dependent substrate degradation, a critical feature of progression through mitosis, was long known to be controlled by mechanisms targeting the core APC/C-machinery. Recent experiments, however have revealed an important contribution of substrate-specific regulation of the APC/C to achieve accurate cell division. In this perspective, we describe different mechanisms of substrate-specific APC/C-regulation and discuss their importance for cell division. PMID:21191176

Quorum Sensing: A Transcriptional Regulatory System Involved in the Pathogenicity of Burkholderia mallei

DTIC Science & Technology

2004-11-01

contributes to the pathogenicity of B. mallei in vivo. Burkholderia mallei , the etiologic agent of glanders , is a Many gram-negative bacteria possess...A Transcriptional Regulatory System that Contributes to the Virulence of Burkholderia mallei and Burkholderia pseudomallei. Submission Information... Burkholderia mallei Ricky L. Ulrich,’* David DeShazer,1 Harry B. lines,2 and Jeffrey A. Jeddelohi* Bacteriology Division’ and ToxinoloSy/Aerobiology

Environmental Effects on the Adhesion of Entermorpha clathrata.

DTIC Science & Technology

1979-04-18

rhizoidal outgrowth (holdfast) at the base (Figure 1). The cells of the thallus are rectangular and in distinct longitudi- nal series. There is a single...parthenogenetic gametes differentiate into a thalli cell and a rhizoidal cell after the first cellular division. All cells which originate from the... rhizoidal cell contribute to the holdfast attachment system while cells which developed from the thalli cell contribute to the erect, photosynthetic

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kennedy, W.S.; Kovacic, S.M.; Rea, E.C.

The development of ballistic missiles and particularly intercontinental ballistic missiles (ICBMs) by the U.S. space technology manufacturer is examined. Collaboration by the company with the U.S. Air Force is described which began in the 1950s and combined systems engineering and technical assistance. Missile products reviewed in this paper include Atlas, Thor, Titans I and II, Minuteman I, II, III, the Peacekeeper, and the small ICBM. The company developed facilities and programs to support the R and D activities for the missile products, and descriptions are given of the Space Technologies Laboratory and the Ballistic Missiles Division. Contributions to ICBM technologiesmore » by the concern include carbon-carbon nozzle materials, propellant formulation data, movable nozzles, casting techniques for large volumes of propellants, and studies of fracture mechanics. 41 refs.« less

Biomedical wellness challenges and opportunities

NASA Astrophysics Data System (ADS)

Tangney, John F.

2012-06-01

The mission of ONR's Human and Bioengineered Systems Division is to direct, plan, foster, and encourage Science and Technology in cognitive science, computational neuroscience, bioscience and bio-mimetic technology, social/organizational science, training, human factors, and decision making as related to future Naval needs. This paper highlights current programs that contribute to future biomedical wellness needs in context of humanitarian assistance and disaster relief. ONR supports fundamental research and related technology demonstrations in several related areas, including biometrics and human activity recognition; cognitive sciences; computational neurosciences and bio-robotics; human factors, organizational design and decision research; social, cultural and behavioral modeling; and training, education and human performance. In context of a possible future with automated casualty evacuation, elements of current science and technology programs are illustrated.

Does telomere elongation lead to a longer lifespan if cancer is considered?

NASA Astrophysics Data System (ADS)

Masa, Michael; Cebrat, Stanisław; Stauffer, Dietrich

2006-05-01

As cell proliferation is limited due to the loss of telomere repeats in DNA of normal somatic cells during division, telomere attrition can possibly play an important role in determining the maximum life span of organisms as well as contribute to the process of biological ageing. With computer simulations of cell culture development in organisms, which consist of tissues of normal somatic cells with finite growth, we obtain an increase of life span and life expectancy for longer telomeric DNA in the zygote. By additionally considering a two-mutation model for carcinogenesis and indefinite proliferation by the activation of telomerase, we demonstrate that the risk of dying due to cancer can outweigh the positive effect of longer telomeres on the longevity.

The Biological and Chemical Oceanography Data Management Office

NASA Astrophysics Data System (ADS)

Allison, M. D.; Chandler, C. L.; Groman, R. C.; Wiebe, P. H.; Glover, D. M.; Gegg, S. R.

2011-12-01

Oceanography and marine ecosystem research are inherently interdisciplinary fields of study that generate and require access to a wide variety of measurements. In late 2006 the Biological and Chemical Oceanography Sections of the National Science Foundation (NSF) Geosciences Directorate Division of Ocean Sciences (OCE) funded the Biological and Chemical Oceanography Data Management Office (BCO-DMO). In late 2010 additional funding was contributed to support management of research data from the NSF Office of Polar Programs Antarctic Organisms & Ecosystems Program. The BCO-DMO is recognized in the 2011 Division of Ocean Sciences Sample and Data Policy as one of several program specific data offices that support NSF OCE funded researchers. BCO-DMO staff members offer data management support throughout the project life cycle to investigators from large national programs and medium-sized collaborative research projects, as well as researchers from single investigator awards. The office manages and serves all types of oceanographic data and information generated during the research process and contributed by the originating investigators. BCO-DMO has built a data system that includes the legacy data from several large ocean research programs (e.g. United States Joint Global Ocean Flux Study and United States GLOBal Ocean ECosystems Dynamics), to which data have been contributed from recently granted NSF OCE and OPP awards. The BCO-DMO data system can accommodate many different types of data including: in situ and experimental biological, chemical, and physical measurements; modeling results and synthesis data products. The system enables reuse of oceanographic data for new research endeavors, supports synthesis and modeling activities, provides availability of "real data" for K-12 and college level use, and provides decision-support field data for policy-relevant investigations. We will present an overview of the data management system capabilities including: map-based and text-based data discovery and access systems; recent enhancements to data search tools; data export and download utilities; and strategic use of controlled vocabularies to facilitate data integration and to improve data system interoperability.

Studies in Illumination. 1. The Hygienic Conditions of Illumination in Certain Post Offices, Especially Relating to Visual Defects and Efficiency

DTIC Science & Technology

1924-07-01

OFFICE. The primary function of the Postal Service is to transfer mail from the sender to the addressee. The major. activities at all post offices in...points. These two divisions are officially designated as the delivery and dispatching divisions, re- spectively. The four other official divisions of...class mail is separated for distribution .outside New York City, it is transported by chute or truck to the pouching department. The work required here

Life Sciences Division annual report, 1988

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marrone, B.L.; Cram, L.S.

1989-04-01

This report summarizes the research and development activities of Los Alamos National Laboratory's Life Sciences Division for the calendar year 1988. Technical reports related to the current status of projects are presented in sufficient detail to permit the informed reader to assess their scope and significance. Summaries useful to the casual reader desiring general information have been prepared by the Group Leaders and appear in each group overview. Investigators on the staff of the Life Sciences Division will be pleased to provide further information.

Tomato leaf curl Yunnan virus-encoded C4 induces cell division through enhancing stability of Cyclin D 1.1 via impairing NbSKη -mediated phosphorylation in Nicotiana benthamiana

PubMed Central

Mei, Yuzhen; Yang, Xiuling; Huang, Changjun

2018-01-01

The whitefly-transmitted geminiviruses induce severe developmental abnormalities in plants. Geminivirus-encoded C4 protein functions as one of viral symptom determinants that could induce abnormal cell division. However, the molecular mechanism by which C4 contributes to cell division induction remains unclear. Here we report that tomato leaf curl Yunnan virus (TLCYnV) C4 interacts with a glycogen synthase kinase 3 (GSK3)/SHAGGY-like kinase, designed NbSKη, in Nicotiana benthamiana. Pro32, Asn34 and Thr35 of TLCYnV C4 are critical for its interaction with NbSKη and required for C4-induced typical symptoms. Interestingly, TLCYnV C4 directs NbSKη to the membrane and reduces the nuclear-accumulation of NbSKη. The relocalization of NbSKη impairs phosphorylation dependent degradation on its substrate-Cyclin D1.1 (NbCycD1;1), thereby increasing the accumulation level of NbCycD1;1 and inducing the cell division. Moreover, NbSKη-RNAi, 35S::NbCycD1;1 transgenic N. benthamiana plants have the similar phenotype as 35S::C4 transgenic N. benthamiana plants on callus-like tissue formation resulted from abnormal cell division induction. Thus, this study provides new insights into mechanism of how a viral protein hijacks NbSKη to induce abnormal cell division in plants. PMID:29293689

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Staff - Simone Montayne | Alaska Division of Geological & Geophysical

Science.gov Websites

Alaska's Mineral Industry Reports AKGeology.info Rare Earth Elements WebGeochem Engineering Geology Alaska Preservation Workshop Professional Experience Metadata - Simone compiles all of the division's metadata files Professional Activities Website and database administrator for the Association of American State Geologists

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A Conserved RhoGAP Limits M-phase Contractility and Coordinates with Microtubule Asters to Restrict Active RhoA to the Cell Equator During Cytokinesis

PubMed Central

Zanin, Esther; Desai, Arshad; Poser, Ina; Toyoda, Yusuke; Andree, Cordula; Moebius, Claudia; Bickle, Marc; Conradt, Barbara; Piekny, Alisa; Oegema, Karen

2014-01-01

SUMMARY During animal cell cytokinesis, the spindle directs contractile ring assembly by activating RhoA in a narrow equatorial zone. Rapid GTPase activating protein (GAP)-mediated inactivation (RhoA flux) is proposed to limit RhoA zone dimensions. Testing the significance of RhoA flux has been hampered by the fact that the GAP targeting RhoA is not known. Here, we identify M-phase GAP (MP-GAP) as the primary GAP targeting RhoA during mitosis/cytokinesis. MP-GAP inhibition caused excessive RhoA activation in M-phase leading to the uncontrolled formation of large cortical protrusions and late cytokinesis failure. RhoA zone width was broadened by attenuation of the centrosomal asters but was not affected by MP-GAP inhibition alone. Simultaneous aster attenuation and MP-GAP inhibition led to RhoA accumulation around the entire cell periphery. These results identify the major GAP restraining RhoA during cell division and delineate the relative contributions of RhoA flux and centrosomal asters in controlling RhoA zone dimensions. PMID:24012485

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

The Chemical Technology (CMT) Division is a diverse technical organization with principal emphases in environmental management and development of advanced energy sources. The Division conducts research and development in three general areas: (1) development of advanced power sources for stationary and transportation applications and for consumer electronics, (2) management of high-level and low-level nuclear wastes and hazardous wastes, and (3) electrometallurgical treatment of spent nuclear fuel. The Division also performs basic research in catalytic chemistry involving molecular energy resources, mechanisms of ion transport in lithium battery electrolytes, and the chemistry of technology-relevant materials and electrified interfaces. In addition, the Divisionmore » operates the Analytical Chemistry Laboratory, which conducts research in analytical chemistry and provides analytical services for programs at Argonne National Laboratory (ANL) and other organizations. Technical highlights of the Division`s activities during 1997 are presented.« less

Cyclin D regulation of a sexually dimorphic asymmetric cell division

PubMed Central

Tilmann, Christopher; Kimble, Judith

2006-01-01

SUMMARY The C. elegans somatic gonadal precursor cell (SGP) divides asymmetrically to establish gonad-specific coordinates in both sexes. In addition, the SGP division is sexually dimorphic and initiates sex-specific programs of gonadogenesis. Wnt/MAPK signaling determines the gonadal axes, and the FKH-6 transcription factor specifies the male mode of SGP division. In this paper, we demonstrate that C. elegans cyclin D controls POP-1/TCF asymmetry in the SGP daughters as well as fkh-6 and rnr expression in the SGPs. Although cyclin D mutants have delayed SGP divisions, the cyclin D defects are not mimicked by other methods of retarding the SGP division. We find that EFL-1/E2F has an antagonistic effect on fkh-6 expression and gonadogenesis, which is relieved by cyclin D activity. We propose that cyclin D and other canonical regulators of the G1/S transition coordinate key regulators of axis formation and sex determination with cell cycle progression to achieve the sexually dimorphic SGP asymmetric division. PMID:16198291

Clinical Trials Reference Materials and Related Links | Division of Cancer Prevention

Cancer.gov

Agreements Clinical Trials Agreement Confidential Disclosure Agreements Cooperative Research and Development Agreement (CRADA) - Research Plan Financial and Staffing Contribution of the Parties Exception or Modifications to the CRADA Human Subject Protection/Informed Consent Tutorials (or Education) |

Genes and the Microenvironment: Two Faces of Breast Cancer (LBNL Science at the Theater)

ScienceCinema

Gray, Joe; Love, Susan M.; Bissell, Min; Barcellos-Hoff, Mary Helen

2018-05-24

In this April 21, 2008 Berkeley Lab event, a dynamic panel of Berkeley Lab scientists highlight breast cancer research advances related to susceptibility, early detection, prevention, and therapy - a biological systems approach to tackling the disease from the molecular and cellular levels, to tissues and organs, and ultimately the whole individual. Joe Gray, Berkeley Lab Life Sciences Division Director, explores how chromosomal abnormalities contribute to cancer and respond to gene-targeted therapies. Mina Bissell, former Life Sciences Division Director, approaches the challenge of breast cancer from the breast's three dimensional tissue microenvironment and how the intracellular ''conversation'' triggers malignancies. Mary Helen Barcellos-Hoff, Deputy Director, Life Sciences Division, identifies what exposure to ionizing radiation can tell us about how normal tissues suppress carcinogenesis. The panel is moderated by Susan M. Love, breast cancer research pioneer, author, President and Medical Director of the Dr. Susan Love Research Foundation.

Genes and the Microenvironment: Two Faces of Breast Cancer (LBNL Science at the Theater)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gray, Joe; Love, Susan M.; Bissell, Min

In this April 21, 2008 Berkeley Lab event, a dynamic panel of Berkeley Lab scientists highlight breast cancer research advances related to susceptibility, early detection, prevention, and therapy - a biological systems approach to tackling the disease from the molecular and cellular levels, to tissues and organs, and ultimately the whole individual. Joe Gray, Berkeley Lab Life Sciences Division Director, explores how chromosomal abnormalities contribute to cancer and respond to gene-targeted therapies. Mina Bissell, former Life Sciences Division Director, approaches the challenge of breast cancer from the breast's three dimensional tissue microenvironment and how the intracellular ''conversation'' triggers malignancies. Marymore » Helen Barcellos-Hoff, Deputy Director, Life Sciences Division, identifies what exposure to ionizing radiation can tell us about how normal tissues suppress carcinogenesis. The panel is moderated by Susan M. Love, breast cancer research pioneer, author, President and Medical Director of the Dr. Susan Love Research Foundation.« less

Symmetric vs. Asymmetric Stem Cell Divisions: An Adaptation against Cancer?

PubMed Central

Shahriyari, Leili; Komarova, Natalia L.

2013-01-01

Traditionally, it has been held that a central characteristic of stem cells is their ability to divide asymmetrically. Recent advances in inducible genetic labeling provided ample evidence that symmetric stem cell divisions play an important role in adult mammalian homeostasis. It is well understood that the two types of cell divisions differ in terms of the stem cells' flexibility to expand when needed. On the contrary, the implications of symmetric and asymmetric divisions for mutation accumulation are still poorly understood. In this paper we study a stochastic model of a renewing tissue, and address the optimization problem of tissue architecture in the context of mutant production. Specifically, we study the process of tumor suppressor gene inactivation which usually takes place as a consequence of two “hits”, and which is one of the most common patterns in carcinogenesis. We compare and contrast symmetric and asymmetric (and mixed) stem cell divisions, and focus on the rate at which double-hit mutants are generated. It turns out that symmetrically-dividing cells generate such mutants at a rate which is significantly lower than that of asymmetrically-dividing cells. This result holds whether single-hit (intermediate) mutants are disadvantageous, neutral, or advantageous. It is also independent on whether the carcinogenic double-hit mutants are produced only among the stem cells or also among more specialized cells. We argue that symmetric stem cell divisions in mammals could be an adaptation which helps delay the onset of cancers. We further investigate the question of the optimal fraction of stem cells in the tissue, and quantify the contribution of non-stem cells in mutant production. Our work provides a hypothesis to explain the observation that in mammalian cells, symmetric patterns of stem cell division seem to be very common. PMID:24204602

76 FR 6460 - Agency Information Collection Activities; Proposed Collection; Comment Request; Reporting and...

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17 CFR 200.735-4 - Outside employment and activities.

Code of Federal Regulations, 2010 CFR

2010-04-01

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Divisions of geologic time (Bookmark)

USGS Publications Warehouse

,

2012-05-03

DescriptionThis bookmark, designed for use with U.S. Geological Survey activities at the second USA Science and Engineering Festival (April 26–29, 2012), is adapted from the more detailed Fact Sheet 2010–3059 "Divisions of Geologic Time." The information that it presents is widely sought by educators and students.

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33 CFR 211.24 - Disposition of claims.

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2010-07-01

... Section 211.24 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE REAL ESTATE ACTIVITIES OF THE CORPS OF ENGINEERS IN CONNECTION WITH CIVIL WORKS PROJECTS Real... damages not exceeding $1,000 may be settled by the Division Engineer. If the Division Engineer allows the...

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Physics Division annual review, 1 April 1975--31 March 1976. [ANL

DOE Office of Scientific and Technical Information (OSTI.GOV)

Garvey, G. T.

1976-01-01

An overview is given of Physics Division activities in the following areas: the heavy-ion booster; medium-energy physics; heavy-ion physics; low-energy charged-particle physics; accelerator operations; neutron physics; theoretical nuclear physics, and atomic and molecular physics. A bibliography of publications amounts to 27 pages. (RWR)

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The North Carolina Division of Public Health's vision for healthy and sustainable communities.

PubMed

Thomas, Cathy; Rhew, Lori K; Petersen, Ruth

2012-01-01

The North Carolina Division of Public Health is working to improve access to physical activity through changes in the built environment by participating in the Healthy Environments Collaborative and by leading the state's Communities Putting Prevention to Work project and the Shape Your World movement.

Cultural Relevance and Educational Issues: Readings in Anthropology and Education.

ERIC Educational Resources Information Center

Ianni, Francis A. J., Ed.; Storey, Edward, Ed.

The recent activity of anthropologists whose primary interest are in education and of educators whose orientation is anthropological suggests this division of labor: The first division, "anthropology and education," is the most expansive and the least specific. A second, "anthropology in education," concerns the anthropological presence, whether…

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The Association for Educational Communications and Technology: Division of School Media Specialists.

ERIC Educational Resources Information Center

Miller, Mary Mock

1993-01-01

Reports on the Division of School Media Specialists of the Association for Educational Communications and Technology (AECT). Highlights include the mission statement; publications; board members and committee chairs; activities at the AECT conferences; and future concerns, including public relations and marketing plans for media specialists and…

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30 CFR 910.817 - Performance standards-underground mining activities.

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... with the Georgia Safe Dams Act and Rules for Safety of the Natural Resources, Environmental Protection Division; the Solid Waste Management Rules of the Georgia Department of Natural Resources, Environmental Protection Division, Chapter 391-3-4; and the Georgia Seed Laws and Regulation 4. [47 FR 36399, Aug. 19, 1982...

30 CFR 910.817 - Performance standards-underground mining activities.

Code of Federal Regulations, 2012 CFR

2012-07-01

... with the Georgia Safe Dams Act and Rules for Safety of the Natural Resources, Environmental Protection Division; the Solid Waste Management Rules of the Georgia Department of Natural Resources, Environmental Protection Division, Chapter 391-3-4; and the Georgia Seed Laws and Regulation 4. [47 FR 36399, Aug. 19, 1982...

30 CFR 910.816 - Performance standards-surface mining activities.

Code of Federal Regulations, 2012 CFR

2012-07-01

... except in compliance with the Georgia Safe Dams Act and Rules for Safety of the Natural Resources, Environmental Protection Division; the Solid Waste Management Rules of the Georgia Department of Natural Resources, Environmental Protection Division, Chapter 391-3-4; and the Georgia Seed Laws and Regulation 4...

30 CFR 910.816 - Performance standards-surface mining activities.

Code of Federal Regulations, 2014 CFR

2014-07-01

... except in compliance with the Georgia Safe Dams Act and Rules for Safety of the Natural Resources, Environmental Protection Division; the Solid Waste Management Rules of the Georgia Department of Natural Resources, Environmental Protection Division, Chapter 391-3-4; and the Georgia Seed Laws and Regulation 4...

Active Grants | Division of Cancer Prevention

Cancer.gov

The Division of Cancer Prevention (DCP) conducts and supports research to determine a person's risk of cancer and to find ways to reduce the risk. This knowledge is critical to making progress against cancer because risk varies over the lifespan as genetic and epigenetic changes can transform healthy tissue into invasive cancer.

75 FR 9433 - Civil Rights Division, Disability Rights Section; Agency Information Collection Activities Under...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-02

... DEPARTMENT OF JUSTICE OMB Number 1190-0004] Civil Rights Division, Disability Rights Section... be directed to John Wodatch (phone number and address listed below). If you have additional comments... Basis of Disability in State and Local Government Services (Transition Plan). (3) The agency form number...

78 FR 26379 - National Cancer Institute; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-06

... Methodological Research for Cancer Epidemiology Cohorts. Date: June 25, 2013. Time: 11:00 a.m. to 4:00 p.m... Officer, Research Programs Review Branch, Division of Extramural Activities, National Cancer Institute... Person: David G. Ransom, Ph.D., Scientific Review Officer, Research Programs Review Branch, Division of...

75 FR 66422 - Agency Information Collection Activities: Requests for Comments; Clearance of Renewed Approval of...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-28

... Enterprises Business Services Division, AES-200, 800 Independence Ave., SW., Washington, DC 20591. Public... Information Collection Clearance Officer, IT Enterprises Business Services Division, AES-200. [FR Doc. 2010... about our intention to request the Office of Management and Budget (OMB) approval to renew an...

76 FR 13267 - Agency Information Collection Activities: Requests for Comments; Clearance of Renewed Approval of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-10

..., IT Enterprises Business Services Division, AES-200, 800 Independence Ave., SW., Washington, DC 20591... Information Collection Clearance Officer, IT Enterprises Business Services Division, AES-200. [FR Doc. 2011... about our intention to request the Office of Management and Budget (OMB) approval to renew an...

76 FR 13265 - Agency Information Collection Activities: Requests for Comments; Clearance of Renewed Approval of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-10

... Administration, IT Enterprises Business Services Division, AES-200, 800 Independence Ave., SW., Washington, DC.... Carla Scott, FAA Information Collection Clearance Officer, IT Enterprises Business Services Division... invites public comments about our intention to request the Office of Management and Budget (OMB) approval...

76 FR 13266 - Agency Information Collection Activities: Requests for Comments; Clearance of Renewed Approval of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-10

..., IT Enterprises Business Services Division, AES-200, 800 Independence Ave., SW., Washington, DC 20591... Information Collection Clearance Officer, IT Enterprises Business Services Division, AES-200. [FR Doc. 2011... about our intention to request the Office of Management and Budget (OMB) approval to renew an...

Activation of Rho GTPase Cdc42 promotes adhesion and invasion in colorectal cancer cells.

PubMed

Gao, Lei; Bai, Lan; Nan, Qing zhen

2013-07-25

The purpose of this study was to investigate the role of activated Rho GTPase cell division control protein 42 homolog (Cdc42) in colorectal cancer cell adhesion, migration, and invasion. The constitutively active form of Cdc42 (GFP-Cdc42L61) or control vector was overexpressed in the colorectal cancer cell line SW480. The localization of active Cdc42 was monitored by immunofluorescence staining, and the effects of active Cdc42 on cell migration and invasion were examined using an attachment assay, a wound healing assay, and a Matrigel migration assay in vitro. Immunofluorescence staining revealed that constitutively active Cdc42 predominately localized to the plasma membrane. Compared to SW480 cells transfected with the control vector, overexpression of constitutively active Cdc42 in SW480 cells promoted filopodia formation and cell stretch and dramatically enhanced cell adhesion to the coated plates. The wound healing assay revealed a significant increase of migration capability in SW480 cells expressing active Cdc42 compared to the control cells. Additionally, the Matrigel invasion assay demonstrated that active Cdc42 significantly promoted SW480 cell migration through the chamber. Our results suggest that active Rho GTPase Cdc42 can greatly enhance colorectal cancer cell SW480 to spread, migrate, and invade, which may contribute to colorectal cancer metastasis.

Lead from the center. How to manage divisions dynamically.

PubMed

Raynor, M E; Bower, J L

2001-05-01

Conventional wisdom holds that a company's divisions should be given almost total autonomy--especially under conditions of uncertainty--because they are closer to emerging technologies, customers, and competitors than corporate headquarters could ever be. But research from Michael Raynor and Joseph Bower suggests that the corporate office should be more, not less, directive in turbulent markets. Rapid changes in an industry make it difficult to predict where and when synergies among divisions might emerge. With so many possibilities and such uncertainty, companies can't afford to sacrifice their ability to flexibly execute business strategy. Corporate headquarters must play an active role in defining the scope of division-level strategy, the authors say, so that divisions do not act in ways that undermine opportunities to collaborate in the future. But neither can companies afford to sacrifice the competitiveness of their divisions as stand-alone businesses. In creating corporate-level strategic flexibility, a corporate office must balance the need for divisional autonomy now with the potential need for cooperation in the future. Through an examination of four corporations--Sprint, WPP, Teradyne, and Viacom--the authors challenge traditional approaches to diversification in which a company's divisions are either related (they share resources and collaborate) or unrelated (they compete for resources and operate as stand-alone businesses). They argue that companies should adopt a dynamic approach to cooperation among divisions, enabling varying degrees of relatedness between divisions depending on strategic circumstances. The authors offer four tactics to help executives manage divisions dynamically.

Psychologists conducting Psychotherapy in 2012: current practices and historical trends among Division 29 members.

PubMed

Norcross, John C; Rogan, Jessica D

2013-12-01

This study updates three similar investigations conducted in 1981, 1991, and 2001 on APA Division of Psychotherapy members in order to paint a contemporary portrait of psychologists conducting psychotherapy and to chronicle historical trends among Division 29 members. Four hundred twenty-eight psychologists (43% response) completed a questionnaire in 2012 regarding their demographic characteristics, professional activities, theoretical orientations, employment settings, and career experiences. The results point to an increasingly female and aging membership, which continues to be employed primarily in private practices and universities. Psychodynamic (27%), integrative (25%), and cognitive (17%) orientations continue to prevail. Professional activities have remained quite similar across the past 30 years with the exception of declines in projective testing and growth in neuropsychological and health testing. Training and career satisfactions remain high as well.

Substantial contribution of extrinsic risk factors to cancer development | Office of Cancer Genomics

Cancer.gov

Recent research has highlighted a strong correlation between tissue-specific cancer risk and the lifetime number of tissue-specific stem-cell divisions. Whether such correlation implies a high unavoidable intrinsic cancer risk has become a key public health debate with the dissemination of the 'bad luck' hypothesis. Here we provide evidence that intrinsic risk factors contribute only modestly (less than ~10-30% of lifetime risk) to cancer development.

DoD Veterinary Service Activity Role in DoD Food Safety.

DTIC Science & Technology

1998-01-01

medical research and development; zoonotic disease prevention and control; and food safety and quality assurance. The latter mission is not all encompassing...within DoD. This paper reviews the division of responsibilities, within DoD, for food safety and quality assurance. The complexity of the division...and the problem it causes joint operations planners are explored. A proposal for integrating overall strategic responsibility for food safety and quality assurance into the DoD Veterinary Service Activity is developed.

Biomedical Research Group, Health Division annual report 1954

DOE Office of Scientific and Technical Information (OSTI.GOV)

Langham, W.H.; Storer, J.B.

1955-12-31

This report covers the activities of the Biomedical Research Group (H-4) of the Health Division during the period January 1 through December 31, 1954. Organizationally, Group H-4 is divided into five sections, namely, Biochemistry, Radiobiology, Radiopathology, Biophysics, and Organic Chemistry. The activities of the Group are summarized under the headings of the various sections. The general nature of each section`s program, publications, documents and reports originating from its members, and abstracts and summaries of the projects pursued during the year are presented.

Scientific Goals of the Human Genome Project.

ERIC Educational Resources Information Center

Wills, Christopher

1993-01-01

The Human Genome Project, an effort to sequence all the DNA of a human cell, is needed to better understand the behavior of chromosomes during cell division, with the ultimate goal of understanding the specific genes contributing to specific diseases and disabilities. (MSE)

Comparison of Concussion Rates Between NCAA Division I and Division III Men's and Women's Ice Hockey Players.

PubMed

Rosene, John M; Raksnis, Bryan; Silva, Brie; Woefel, Tyler; Visich, Paul S; Dompier, Thomas P; Kerr, Zachary Y

2017-09-01

Examinations related to divisional differences in the incidence of sports-related concussions (SRC) in collegiate ice hockey are limited. To compare the epidemiologic patterns of concussion in National Collegiate Athletic Association (NCAA) ice hockey by sex and division. Descriptive epidemiology study. A convenience sample of men's and women's ice hockey teams in Divisions I and III provided SRC data via the NCAA Injury Surveillance Program during the 2009-2010 to 2014-2015 academic years. Concussion counts, rates, and distributions were examined by factors including injury activity and position. Injury rate ratios (IRRs) and injury proportion ratios (IPRs) with 95% confidence intervals (CIs) were used to compare concussion rates and distributions, respectively. Overall, 415 concussions were reported for men's and women's ice hockey combined. The highest concussion rate was found in Division I men (0.83 per 1000 athlete-exposures [AEs]), followed by Division III women (0.78/1000 AEs), Division I women (0.65/1000 AEs), and Division III men (0.64/1000 AEs). However, the only significant IRR was that the concussion rate was higher in Division I men than Division III men (IRR = 1.29; 95% CI, 1.02-1.65). The proportion of concussions from checking was higher in men than women (28.5% vs 9.4%; IPR = 3.02; 95% CI, 1.63-5.59); however, this proportion was higher in Division I women than Division III women (18.4% vs 1.8%; IPR = 10.47; 95% CI, 1.37-79.75). The proportion of concussions sustained by goalkeepers was higher in women than men (14.2% vs 2.9%; IPR = 4.86; 95% CI, 2.19-10.77), with findings consistent within each division. Concussion rates did not vary by sex but differed by division among men. Checking-related concussions were less common in women than men overall but more common in Division I women than Division III women. Findings highlight the need to better understand the reasons underlying divisional differences within men's and women's ice hockey and the need to develop concussion prevention strategies specific to each athlete population.

Distinct temporal requirements for autophagy and the proteasome in yeast meiosis

PubMed Central

Wen, Fu-Ping; Guo, Yue-Shuai; Hu, Yang; Liu, Wei-Xiao; Wang, Qian; Wang, Yuan-Ting; Yu, Hai-Yan; Tang, Chao-Ming; Yang, Jun; Zhou, Tao; Xie, Zhi-Ping; Sha, Jia-Hao; Guo, Xuejiang; Li, Wei

2016-01-01

ABSTRACT Meiosis is a special type of cellular renovation that involves 2 successive cell divisions and a single round of DNA replication. Two major degradation systems, the autophagy-lysosome and the ubiquitin-proteasome, are involved in meiosis, but their roles have yet to be elucidated. Here we show that autophagy mainly affects the initiation of meiosis but not the nuclear division. Autophagy works not only by serving as a dynamic recycling system but also by eliminating some negative meiotic regulators such as Ego4 (Ynr034w-a). In a quantitative proteomics study, the proteasome was found to be significantly upregulated during meiotic divisions. We found that proteasomal activity is essential to the 2 successive meiotic nuclear divisions but not for the initiation of meiosis. Our study defines the roles of autophagy and the proteasome in meiosis: Autophagy mainly affects the initiation of meiosis, whereas the proteasome mainly affects the 2 successive meiotic divisions. PMID:27050457

Distinct temporal requirements for autophagy and the proteasome in yeast meiosis.

PubMed

Wen, Fu-ping; Guo, Yue-shuai; Hu, Yang; Liu, Wei-xiao; Wang, Qian; Wang, Yuan-ting; Yu, Hai-Yan; Tang, Chao-ming; Yang, Jun; Zhou, Tao; Xie, Zhi-ping; Sha, Jia-hao; Guo, Xuejiang; Li, Wei

2016-01-01

Meiosis is a special type of cellular renovation that involves 2 successive cell divisions and a single round of DNA replication. Two major degradation systems, the autophagy-lysosome and the ubiquitin-proteasome, are involved in meiosis, but their roles have yet to be elucidated. Here we show that autophagy mainly affects the initiation of meiosis but not the nuclear division. Autophagy works not only by serving as a dynamic recycling system but also by eliminating some negative meiotic regulators such as Ego4 (Ynr034w-a). In a quantitative proteomics study, the proteasome was found to be significantly upregulated during meiotic divisions. We found that proteasomal activity is essential to the 2 successive meiotic nuclear divisions but not for the initiation of meiosis. Our study defines the roles of autophagy and the proteasome in meiosis: Autophagy mainly affects the initiation of meiosis, whereas the proteasome mainly affects the 2 successive meiotic divisions.

Functional requirements of computer systems for the U.S. Geological Survey, Water Resources Division, 1988-97

USGS Publications Warehouse

Hathaway, R.M.; McNellis, J.M.

1989-01-01

Investigating the occurrence, quantity, quality, distribution, and movement of the Nation 's water resources is the principal mission of the U.S. Geological Survey 's Water Resources Division. Reports of these investigations are published and available to the public. To accomplish this mission, the Division requires substantial computer technology to process, store, and analyze data from more than 57,000 hydrologic sites. The Division 's computer resources are organized through the Distributed Information System Program Office that manages the nationwide network of computers. The contract that provides the major computer components for the Water Resources Division 's Distributed information System expires in 1991. Five work groups were organized to collect the information needed to procure a new generation of computer systems for the U. S. Geological Survey, Water Resources Division. Each group was assigned a major Division activity and asked to describe its functional requirements of computer systems for the next decade. The work groups and major activities are: (1) hydrologic information; (2) hydrologic applications; (3) geographic information systems; (4) reports and electronic publishing; and (5) administrative. The work groups identified 42 functions and described their functional requirements for 1988, 1992, and 1997. A few new functions such as Decision Support Systems and Executive Information Systems, were identified, but most are the same as performed today. Although the number of functions will remain about the same, steady growth in the size, complexity, and frequency of many functions is predicted for the next decade. No compensating increase in the Division 's staff is anticipated during this period. To handle the increased workload and perform these functions, new approaches will be developed that use advanced computer technology. The advanced technology is required in a unified, tightly coupled system that will support all functions simultaneously. The new approaches and expanded use of computers will require substantial increases in the quantity and sophistication of the Division 's computer resources. The requirements presented in this report will be used to develop technical specifications that describe the computer resources needed during the 1990's. (USGS)

A genetic screen for temperature-sensitive cell-division mutants of Caenorhabditis elegans.

PubMed Central

O'Connell, K F; Leys, C M; White, J G

1998-01-01

A novel screen to isolate conditional cell-division mutants in Caenorhabditis elegans has been developed. The screen is based on the phenotypes associated with existing cell-division mutations: some disrupt postembryonic divisions and affect formation of the gonad and ventral nerve cord-resulting in sterile, uncoordinated animals-while others affect embryonic divisions and result in lethality. We obtained 19 conditional mutants that displayed these phenotypes when shifted to the restrictive temperature at the appropriate developmental stage. Eighteen of these mutations have been mapped; 17 proved to be single alleles of newly identified genes, while 1 proved to be an allele of a previously identified gene. Genetic tests on the embryonic lethal phenotypes indicated that for 13 genes, embryogenesis required maternal expression, while for 6, zygotic expression could suffice. In all cases, maternal expression of wild-type activity was found to be largely sufficient for embryogenesis. Cytological analysis revealed that 10 mutants possessed embryonic cell-division defects, including failure to properly segregate DNA, failure to assemble a mitotic spindle, late cytokinesis defects, prolonged cell cycles, and improperly oriented mitotic spindles. We conclude that this approach can be used to identify mutations that affect various aspects of the cell-division cycle. PMID:9649522

An Equatorial Contractile Mechanism Drives Cell Elongation but not Cell Division

PubMed Central

Denker, Elsa; Bhattachan, Punit; Deng, Wei; Mathiesen, Birthe T.; Jiang, Di

2014-01-01

Cell shape changes and proliferation are two fundamental strategies for morphogenesis in animal development. During embryogenesis of the simple chordate Ciona intestinalis, elongation of individual notochord cells constitutes a crucial stage of notochord growth, which contributes to the establishment of the larval body plan. The mechanism of cell elongation is elusive. Here we show that although notochord cells do not divide, they use a cytokinesis-like actomyosin mechanism to drive cell elongation. The actomyosin network forming at the equator of each notochord cell includes phosphorylated myosin regulatory light chain, α-actinin, cofilin, tropomyosin, and talin. We demonstrate that cofilin and α-actinin are two crucial components for cell elongation. Cortical flow contributes to the assembly of the actomyosin ring. Similar to cytokinetic cells, membrane blebs that cause local contractions form at the basal cortex next to the equator and participate in force generation. We present a model in which the cooperation of equatorial actomyosin ring-based constriction and bleb-associated contractions at the basal cortex promotes cell elongation. Our results demonstrate that a cytokinesis-like contractile mechanism is co-opted in a completely different developmental scenario to achieve cell shape change instead of cell division. We discuss the occurrences of actomyosin rings aside from cell division, suggesting that circumferential contraction is an evolutionally conserved mechanism to drive cell or tissue elongation. PMID:24503569

Active Chemopreventive Agent Development Grants | Division of Cancer Prevention

Cancer.gov

The Division of Cancer Prevention (DCP) conducts and supports research to determine a person's risk of cancer and to find ways to reduce the risk. This knowledge is critical to making progress against cancer because risk varies over the lifespan as genetic and epigenetic changes can transform healthy tissue into invasive cancer.

Active Supportive and Palliative Care Research Grants | Division of Cancer Prevention

Cancer.gov

The Division of Cancer Prevention (DCP) conducts and supports research to determine a person's risk of cancer and to find ways to reduce the risk. This knowledge is critical to making progress against cancer because risk varies over the lifespan as genetic and epigenetic changes can transform healthy tissue into invasive cancer.

Active Gastrointestinal and Other Cancers Grants | Division of Cancer Prevention

Cancer.gov

The Division of Cancer Prevention (DCP) conducts and supports research to determine a person's risk of cancer and to find ways to reduce the risk. This knowledge is critical to making progress against cancer because risk varies over the lifespan as genetic and epigenetic changes can transform healthy tissue into invasive cancer.

Active Early Detection Grants | Division of Cancer Prevention

Cancer.gov

The Division of Cancer Prevention (DCP) conducts and supports research to determine a person's risk of cancer and to find ways to reduce the risk. This knowledge is critical to making progress against cancer because risk varies over the lifespan as genetic and epigenetic changes can transform healthy tissue into invasive cancer.

Active Prostate and Urologic Cancer Grants | Division of Cancer Prevention

Cancer.gov

The Division of Cancer Prevention (DCP) conducts and supports research to determine a person's risk of cancer and to find ways to reduce the risk. This knowledge is critical to making progress against cancer because risk varies over the lifespan as genetic and epigenetic changes can transform healthy tissue into invasive cancer.

Active NCI Community Oncology Research Program Grants | Division of Cancer Prevention

Cancer.gov

The Division of Cancer Prevention (DCP) conducts and supports research to determine a person's risk of cancer and to find ways to reduce the risk. This knowledge is critical to making progress against cancer because risk varies over the lifespan as genetic and epigenetic changes can transform healthy tissue into invasive cancer.

Active Community Oncology and Prevention Trials Grants | Division of Cancer Prevention

Cancer.gov

The Division of Cancer Prevention (DCP) conducts and supports research to determine a person's risk of cancer and to find ways to reduce the risk. This knowledge is critical to making progress against cancer because risk varies over the lifespan as genetic and epigenetic changes can transform healthy tissue into invasive cancer.

Comparison of CDMA and FDMA for the MobileStar(sm) system

NASA Technical Reports Server (NTRS)

Jacobs, I. M.; Gilhousen, K. S.; Weaver, L. A.; Renshaw, K.; Murphy, T.

1988-01-01

Spread-spectrum code division multiple access (CDMA) and single channel per carrier frequency division multiple access (FDMA) systems are compared for spectrum efficiency. CDMA is shown to have greater maximum throughput than FDMA for the MobileStar(sm) system which uses digital voice activated carriers and directive circularly polarized satellite antennas.

75 FR 54464 - Delegation of Authority to the Director of Its Division of Enforcement

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-08

... Division of Enforcement, in connection with the collection of delinquent debts arising from actions to enforce the federal securities laws, to terminate collection activity or discharge debts, to accept or reject offers to compromise debts, and to accept or reject offers to enter into payment plans. This...

78 FR 63971 - Notice of Availability of Record of Decision for Outdoor Research, Development, Test and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-25

... Outdoor Research, Development, Test and Evaluation Activities at Naval Surface Warfare Center, Dahlgren Division, Dahlgren, VA AGENCY: Department of the Navy, DoD. ACTION: Notice. SUMMARY: The Department of the... proposed action, announces its decision to expand the Naval Surface Warfare Center, Dahlgren Division's...

28 CFR 0.52 - Certifications under 18 U.S.C. 3503.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Rights Division § 0.52 Certifications under 18 U.S.C. 3503. The Assistant Attorney General in charge of the Civil Rights Division and his Deputy Assistant Attorney Generals are each authorized to exercise... made, is against a person who is believed to have participated in an organized criminal activity, where...

Active Nutritional Science Grants | Division of Cancer Prevention

Cancer.gov

The Division of Cancer Prevention (DCP) conducts and supports research to determine a person's risk of cancer and to find ways to reduce the risk. This knowledge is critical to making progress against cancer because risk varies over the lifespan as genetic and epigenetic changes can transform healthy tissue into invasive cancer.

77 FR 70482 - Notice of Establishment of a NASA Federal Advisory Committee; Applied Sciences Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-26

... Analysis Group (ASAG) as a task group under the auspices of the Earth Science Subcommittee of the NASA... and prioritizing the Earth Science Division's Applied Sciences Program activities and has served as a... recommendations to the Director, Earth Science Division, Science Mission Directorate, NASA Headquarters, on...

Making Connections in Math: Activating a Prior Knowledge Analogue Matters for Learning

ERIC Educational Resources Information Center

Sidney, Pooja G.; Alibali, Martha W.

2015-01-01

This study investigated analogical transfer of conceptual structure from a prior-knowledge domain to support learning in a new domain of mathematics: division by fractions. Before a procedural lesson on division by fractions, fifth and sixth graders practiced with a surface analogue (other operations on fractions) or a structural analogue (whole…

Active Cancer Biomarkers Grants | Division of Cancer Prevention

Cancer.gov

The Division of Cancer Prevention (DCP) conducts and supports research to determine a person's risk of cancer and to find ways to reduce the risk. This knowledge is critical to making progress against cancer because risk varies over the lifespan as genetic and epigenetic changes can transform healthy tissue into invasive cancer.

IFLA General Conference, 1985. Division on Collections and Services. Section on Interlending and Document Delivery. Papers.

ERIC Educational Resources Information Center

International Federation of Library Associations, The Hague (Netherlands).

Papers on interlibrary loans and document delivery which were presented at the 1985 International Federation of Library Associations (IFLA) conference include: (1) "The Activities of the IFLA Office for International Lending" (Richard J. Bennett, British Library Lending Division, United Kingdom); (2) "Electronic Networking for…

Active Lung and Upper Aerodigestive Cancer Grants | Division of Cancer Prevention

Cancer.gov

The Division of Cancer Prevention (DCP) conducts and supports research to determine a person's risk of cancer and to find ways to reduce the risk. This knowledge is critical to making progress against cancer because risk varies over the lifespan as genetic and epigenetic changes can transform healthy tissue into invasive cancer.

A Case Study on TRICARE Online Web-enabled Appointing: Improving Utilization Rates at Navy Medical Treatment Facilities

DTIC Science & Technology

2009-10-20

Low usage volume raised concerns about the effectiveness of TOL. In 2004, the eHealth Division of TMA Information Management conducted a study to...Case Study 31 (Version 15.8). Falls Church, VA: Department of Defense, TRICARE Management Activity, Information Management eHealth Division

Can Peer Instruction Be Effective in Upper-Division Computer Science Courses?

ERIC Educational Resources Information Center

Bailey Lee, Cynthia; Garcia, Saturnino; Porter, Leo

2013-01-01

Peer Instruction (PI) is an active learning pedagogical technique. PI lectures present students with a series of multiple-choice questions, which they respond to both individually and in groups. PI has been widely successful in the physical sciences and, recently, has been successfully adopted by computer science instructors in lower-division,…

Active Breast and Gynecologic Cancer Grants | Division of Cancer Prevention

Cancer.gov

The Division of Cancer Prevention (DCP) conducts and supports research to determine a person's risk of cancer and to find ways to reduce the risk. This knowledge is critical to making progress against cancer because risk varies over the lifespan as genetic and epigenetic changes can transform healthy tissue into invasive cancer.

75 FR 9434 - Civil Rights Division, Disability Rights Section; Agency Information Collection Activities Under...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-02

... Rights (or his or her designee) may certify that a State or local building code or similar ordinance that establishes accessibility requirements (Code) meets or exceeds the minimum requirements of the ADA for..., Policy and Planning Staff, Justice Management Division, Patrick Henry Building, Suite 1600, 601 D Street...

75 FR 27816 - Civil Rights Division, Disability Rights Section; Agency Information Collection Activities Under...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-18

... certify that a State or local building code or similar ordinance that establishes accessibility requirements (Code) meets or exceeds the minimum requirements of the ADA for accessibility and usability of... Management Division, Patrick Henry Building, Suite 1600, 601 D Street, NW., Washington, DC 20530. Dated: May...

77 FR 57569 - Science Advisory Board to the National Center for Toxicological Research; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-18

... overview of research activities from the NCTR Division of Bioinformatics and Computational Biology and the Division of Systems Biology. The SAB will also receive and update from the subcommittee on Immunotoxicology... advisory committee meetings and will make every effort to accommodate persons with physical disabilities or...

Active Early Detection Research Network Grants | Division of Cancer Prevention

Cancer.gov

The Division of Cancer Prevention (DCP) conducts and supports research to determine a person's risk of cancer and to find ways to reduce the risk. This knowledge is critical to making progress against cancer because risk varies over the lifespan as genetic and epigenetic changes can transform healthy tissue into invasive cancer.

Active Barrett's Esophagus Translational Research Network Grants | Division of Cancer Prevention

Cancer.gov

The Division of Cancer Prevention (DCP) conducts and supports research to determine a person's risk of cancer and to find ways to reduce the risk. This knowledge is critical to making progress against cancer because risk varies over the lifespan as genetic and epigenetic changes can transform healthy tissue into invasive cancer.

Foreword to special issue: Papers from the 57th Annual Meeting of the APS Division of Plasma Physics, November 16–20, 2015, Savannah, Georgia, USA

DOE PAGES

Meyerhofer, D. D.; Mauel, M. E.

2016-05-18

The 57th annual meeting of the APS Division of Plasma Physics (DPP) was held November 16–20, 2015 in Savannah, Georgia. The meeting brings together researchers (undergraduate students through retirees) from all areas of plasma physics. 1887 abstracts were included in the program, approximately 200 more than the previous year. The presentations included five invited review talks, 97 invited talks, three invited postdeadline talks, and four tutorials. Furthermore, there were approximately 1780 contributed presentations, with about 40% oral and 60% poster. Three mini-conferences were held concurrently.

Coherent UDWDM PON with joint subcarrier reception at OLT.

PubMed

Kottke, Christoph; Fischer, Johannes Karl; Elschner, Robert; Frey, Felix; Hilt, Jonas; Schubert, Colja; Schmidt, Daniel; Wu, Zifeng; Lankl, Berthold

2014-07-14

In this contribution, we report on the experimental investigation of an ultra-dense wavelength-division multiplexing (UDWDM) upstream link with up to 700 × 2.488 Gb/s polarization-division multiplexing differential quadrature phase-shift keying parallel upstream user channels transmitted over 80 km of standard single-mode fiber. We discuss challenges of the digital signal processing in the optical line terminal arising from the joint reception of several upstream user channels. We present solutions for resource and cost-efficient realization of the required channel separation, matched filtering, down-conversion and decimation as well as realization of the clock recovery and polarization demultiplexing for each individual channel.

Foreword to special issue: Papers from the 57th Annual Meeting of the APS Division of Plasma Physics, November 16–20, 2015, Savannah, Georgia, USA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Meyerhofer, D. D.; Mauel, M. E.

The 57th annual meeting of the APS Division of Plasma Physics (DPP) was held November 16–20, 2015 in Savannah, Georgia. The meeting brings together researchers (undergraduate students through retirees) from all areas of plasma physics. 1887 abstracts were included in the program, approximately 200 more than the previous year. The presentations included five invited review talks, 97 invited talks, three invited postdeadline talks, and four tutorials. Furthermore, there were approximately 1780 contributed presentations, with about 40% oral and 60% poster. Three mini-conferences were held concurrently.

Dnmt1-dependent Chk1 pathway suppression is protective against neuron division.

PubMed

Oshikawa, Mio; Okada, Kei; Tabata, Hidenori; Nagata, Koh-Ichi; Ajioka, Itsuki

2017-09-15

Neuronal differentiation and cell-cycle exit are tightly coordinated, even in pathological situations. When pathological neurons re-enter the cell cycle and progress through the S phase, they undergo cell death instead of division. However, the mechanisms underlying mitotic resistance are mostly unknown. Here, we have found that acute inactivation of retinoblastoma (Rb) family proteins (Rb, p107 and p130) in mouse postmitotic neurons leads to cell death after S-phase progression. Checkpoint kinase 1 (Chk1) pathway activation during the S phase prevented the cell death, and allowed the division of cortical neurons that had undergone acute Rb family inactivation, oxygen-glucose deprivation (OGD) or in vivo hypoxia-ischemia. During neurogenesis, cortical neurons became protected from S-phase Chk1 pathway activation by the DNA methyltransferase Dnmt1, and underwent cell death after S-phase progression. Our results indicate that Chk1 pathway activation overrides mitotic safeguards and uncouples neuronal differentiation from mitotic resistance. © 2017. Published by The Company of Biologists Ltd.

Model-based analysis of Arabidopsis leaf epidermal cells reveals distinct division and expansion patterns for pavement and guard cells.

PubMed

Asl, Leila Kheibarshekan; Dhondt, Stijn; Boudolf, Véronique; Beemster, Gerrit T S; Beeckman, Tom; Inzé, Dirk; Govaerts, Willy; De Veylder, Lieven

2011-08-01

To efficiently capture sunlight for photosynthesis, leaves typically develop into a flat and thin structure. This development is driven by cell division and expansion, but the individual contribution of these processes is currently unknown, mainly because of the experimental difficulties to disentangle them in a developing organ, due to their tight interconnection. To circumvent this problem, we built a mathematic model that describes the possible division patterns and expansion rates for individual epidermal cells. This model was used to fit experimental data on cell numbers and sizes obtained over time intervals of 1 d throughout the development of the first leaf pair of Arabidopsis (Arabidopsis thaliana). The parameters were obtained by a derivative-free optimization method that minimizes the differences between the predicted and experimentally observed cell size distributions. The model allowed us to calculate probabilities for a cell to divide into guard or pavement cells, the maximum size at which it can divide, and its average cell division and expansion rates at each point during the leaf developmental process. Surprisingly, average cell cycle duration remained constant throughout leaf development, whereas no evidence for a maximum cell size threshold for cell division of pavement cells was found. Furthermore, the model predicted that neighboring cells of different sizes within the epidermis expand at distinctly different relative rates, which could be verified by direct observations. We conclude that cell division seems to occur independently from the status of cell expansion, whereas the cell cycle might act as a timer rather than as a size-regulated machinery.

The simulation model of growth and cell divisions for the root apex with an apical cell in application to Azolla pinnata.

PubMed

Piekarska-Stachowiak, Anna; Nakielski, Jerzy

2013-12-01

In contrast to seed plants, the roots of most ferns have a single apical cell which is the ultimate source of all cells in the root. The apical cell has a tetrahedral shape and divides asymmetrically. The root cap derives from the distal division face, while merophytes derived from three proximal division faces contribute to the root proper. The merophytes are produced sequentially forming three sectors along a helix around the root axis. During development, they divide and differentiate in a predictable pattern. Such growth causes cell pattern of the root apex to be remarkably regular and self-perpetuating. The nature of this regularity remains unknown. This paper shows the 2D simulation model for growth of the root apex with the apical cell in application to Azolla pinnata. The field of growth rates of the organ, prescribed by the model, is of a tensor type (symplastic growth) and cells divide taking principal growth directions into account. The simulations show how the cell pattern in a longitudinal section of the apex develops in time. The virtual root apex grows realistically and its cell pattern is similar to that observed in anatomical sections. The simulations indicate that the cell pattern regularity results from cell divisions which are oriented with respect to principal growth directions. Such divisions are essential for maintenance of peri-anticlinal arrangement of cell walls and coordinated growth of merophytes during the development. The highly specific division program that takes place in merophytes prior to differentiation seems to be regulated at the cellular level.

Model-Based Analysis of Arabidopsis Leaf Epidermal Cells Reveals Distinct Division and Expansion Patterns for Pavement and Guard Cells1[W][OA

PubMed Central

Asl, Leila Kheibarshekan; Dhondt, Stijn; Boudolf, Véronique; Beemster, Gerrit T.S.; Beeckman, Tom; Inzé, Dirk; Govaerts, Willy; De Veylder, Lieven

2011-01-01

To efficiently capture sunlight for photosynthesis, leaves typically develop into a flat and thin structure. This development is driven by cell division and expansion, but the individual contribution of these processes is currently unknown, mainly because of the experimental difficulties to disentangle them in a developing organ, due to their tight interconnection. To circumvent this problem, we built a mathematic model that describes the possible division patterns and expansion rates for individual epidermal cells. This model was used to fit experimental data on cell numbers and sizes obtained over time intervals of 1 d throughout the development of the first leaf pair of Arabidopsis (Arabidopsis thaliana). The parameters were obtained by a derivative-free optimization method that minimizes the differences between the predicted and experimentally observed cell size distributions. The model allowed us to calculate probabilities for a cell to divide into guard or pavement cells, the maximum size at which it can divide, and its average cell division and expansion rates at each point during the leaf developmental process. Surprisingly, average cell cycle duration remained constant throughout leaf development, whereas no evidence for a maximum cell size threshold for cell division of pavement cells was found. Furthermore, the model predicted that neighboring cells of different sizes within the epidermis expand at distinctly different relative rates, which could be verified by direct observations. We conclude that cell division seems to occur independently from the status of cell expansion, whereas the cell cycle might act as a timer rather than as a size-regulated machinery. PMID:21693673

Control of cleavage spindle orientation in Caenorhabditis elegans: The role of the genes par-2 and par-3

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cheng, N.N.; Kirby, C.M.; Kemphues, K.J.

1995-02-01

Polarized asymmetric divisions play important roles in the development of plants and animals. The first two embryonic cleavages of Caenorhabditis elegans provide an opportunity to study the mechanisms controlling polarized asymmetric divisions. The first cleavage is unequal, producing daughters with different sizes and fates. The daughter blastomeres divide with different orientations at the second cleavage; the anterior blastomere divides equally across the long axis of the egg, whereas the posterior blastomere divides unequally along the long axis. We report here the results of our analysis of the genes par-2 and par-3 with respect to their contribution to the polarity ofmore » these divisions. Strong loss-of-function mutations in both genes lead to an equal first cleavage and an altered second cleavage. Interestingly, the mutations exhibit striking gene-specific differences at the second cleavage. The par-2 mutations lead to transverse spindle orientations in both blastomeres, whereas par-3 mutations lead to longitudinal spindle orientations in both blastomeres. The spindle orientation defects correlate with defects in centrosome movements during both the first and the second cell cycle. Temperature shift experiments with par-2 (it5ts) indicate that the par-2(+) activity is not required after the two-cell stage. Analysis of double mutants shows that par-3 is epistatic to par-2. We propose a model wherein par-2(+) and par-3(+) act in concert during the first cell cycle to affect asymmetric modification of the cytoskeleton. This polar modification leads to different behaviors of centrosomes in the anterior and posterior and leads ultimately to blastomere-specific spindle orientations at the second cleavage. 44 refs., 5 figs., 5 tabs.« less

How to reduce your inventory: a real world case study.

PubMed

Mack, J A; Jordan, H H

1994-08-01

This case study describes the use of a performance analysis system at the Safety Products Division of Mine Safety Appliances Company, which contributed to the reduction of excess inventories by more than $8,000,000 during the first two years of implementation.

48 CFR 2035.71 - Broad agency announcements.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., approaches, or concepts demonstrated by the proposal. (2) Overall scientific, technical, or economic merits... personnel who are critical in achieving the proposal objectives. (5) Potential contribution of the effort to... clarification purposes only and must be coordinated through the Division of Contracts and Property Management...

Contributions to North American Ethnology, Volume VII: A Dakota-English dictionary

USGS Publications Warehouse

Riggs, Stephen Return; Dorsey, James Owen; Powell, John Wesley

1890-01-01

This volume consists of a Dakota-English dictionary. The Dakota, commonly known as the Sioux, forms the leading and best known division of the Siouan linguistic family. The Dakota language now consists of three well defined dialects, the Santee, Yankton and Teton.

Dads Doing Diapers: Individual and Relational Outcomes Associated with the Division of Childcare across the Transition to Parenthood

PubMed Central

Fillo, Jennifer; Simpson, Jeffry A.; Rholes, W. Steven; Kohn, Jamie L.

2015-01-01

This longitudinal study examined how relative contributions to the division of childcare are related to individual and relational outcomes across the first two years of the transition to parenthood. Data were collected from a large sample of first-time parents 6 weeks before the birth of their child and then at 6, 12, 18, and 24 months postpartum. The results revealed that certain individual differences—especially gender and attachment avoidance—shape individual reactions to childcare, above and beyond the proportion of childcare tasks that partners report completing. Women and less avoidantly attached new parents handle the introduction of childcare tasks better than most men, especially those who are more avoidantly attached. In addition, certain reactions to childcare, such as childcare self-efficacy and perceptions of work-family conflict, moderate the relation between childcare contributions and relationship satisfaction over the course of the transition. We also discuss the need for more research on men’s adjustment during this particularly stressful transition. PMID:25603377

Functional Genomic Analysis of the let-7 Regulatory Network in Caenorhabditis elegans

PubMed Central

Zisoulis, Dimitrios G.; Lovci, Michael T.; Melnik-Martinez, Katya V.; Yeo, Gene W.; Pasquinelli, Amy E.

2013-01-01

The let-7 microRNA (miRNA) regulates cellular differentiation across many animal species. Loss of let-7 activity causes abnormal development in Caenorhabditis elegans and unchecked cellular proliferation in human cells, which contributes to tumorigenesis. These defects are due to improper expression of protein-coding genes normally under let-7 regulation. While some direct targets of let-7 have been identified, the genome-wide effect of let-7 insufficiency in a developing animal has not been fully investigated. Here we report the results of molecular and genetic assays aimed at determining the global network of genes regulated by let-7 in C. elegans. By screening for mis-regulated genes that also contribute to let-7 mutant phenotypes, we derived a list of physiologically relevant potential targets of let-7 regulation. Twenty new suppressors of the rupturing vulva or extra seam cell division phenotypes characteristic of let-7 mutants emerged. Three of these genes, opt-2, prmt-1, and T27D12.1, were found to associate with Argonaute in a let-7–dependent manner and are likely novel direct targets of this miRNA. Overall, a complex network of genes with various activities is subject to let-7 regulation to coordinate developmental timing across tissues during worm development. PMID:23516374

Diverse mitotic functions of the cytoskeletal cross-linking protein Shortstop suggest a role in Dynein/Dynactin activity

PubMed Central

Dewey, Evan B.; Johnston, Christopher A.

2017-01-01

Proper assembly and orientation of the bipolar mitotic spindle is critical to the fidelity of cell division. Mitotic precision fundamentally contributes to cell fate specification, tissue development and homeostasis, and chromosome distribution within daughter cells. Defects in these events are thought to contribute to several human diseases. The underlying mechanisms that function in spindle morphogenesis and positioning remain incompletely defined, however. Here we describe diverse roles for the actin-microtubule cross-linker Shortstop (Shot) in mitotic spindle function in Drosophila. Shot localizes to mitotic spindle poles, and its knockdown results in an unfocused spindle pole morphology and a disruption of proper spindle orientation. Loss of Shot also leads to chromosome congression defects, cell cycle progression delay, and defective chromosome segregation during anaphase. These mitotic errors trigger apoptosis in Drosophila epithelial tissue, and blocking this apoptotic response results in a marked induction of the epithelial–mesenchymal transition marker MMP-1. The actin-binding domain of Shot directly interacts with Actin-related protein-1 (Arp-1), a key component of the Dynein/Dynactin complex. Knockdown of Arp-1 phenocopies Shot loss universally, whereas chemical disruption of F-actin does so selectively. Our work highlights novel roles for Shot in mitosis and suggests a mechanism involving Dynein/Dynactin activation. PMID:28747439

U.S. Geological Survey activities, fiscal year 1981

USGS Publications Warehouse

,

1982-01-01

This U.S. Geological Survey Activities report for fiscal year 1981 presents a summary of the work performed between October 1, 1980 and September 30, 1981. The main sections of this report are: (1) The Year in Review; a brief overview of the significant events of the Geological Survey during fiscal year 1980; (2) Perspectives; essays focusing on specific events (rather than scientific topics) and programs involving multi-Division participation; (3) Missions, Organization, and Budget; a description of the Geological Survey 's major duties and assignments and of the organizational structure that supports its missions; and (4) Division Chapters; a description of the significant accomplishments (rather than a comprehensive program by program discussion) of each of the eight operating Divisions and Offices. Also included are supplementary information regarding key personnel, cooperators, and selected summary budgetary tables. (USGS)

A new class of cyclin dependent kinase in Chlamydomonas is required for coupling cell size to cell division

PubMed Central

Li, Yubing; Liu, Dianyi; López-Paz, Cristina; Olson, Bradley JSC; Umen, James G

2016-01-01

Proliferating cells actively control their size by mechanisms that are poorly understood. The unicellular green alga Chlamydomonas reinhardtii divides by multiple fission, wherein a ‘counting’ mechanism couples mother cell-size to cell division number allowing production of uniform-sized daughters. We identified a sizer protein, CDKG1, that acts through the retinoblastoma (RB) tumor suppressor pathway as a D-cyclin-dependent RB kinase to regulate mitotic counting. Loss of CDKG1 leads to fewer mitotic divisions and large daughters, while mis-expression of CDKG1 causes supernumerous mitotic divisions and small daughters. The concentration of nuclear-localized CDKG1 in pre-mitotic cells is set by mother cell size, and its progressive dilution and degradation with each round of cell division may provide a link between mother cell-size and mitotic division number. Cell-size-dependent accumulation of limiting cell cycle regulators such as CDKG1 is a potentially general mechanism for size control. DOI: http://dx.doi.org/10.7554/eLife.10767.001 PMID:27015111

Domain-swapping analysis of FtsI, FtsL, and FtsQ, bitopic membrane proteins essential for cell division in Escherichia coli.

PubMed Central

Guzman, L M; Weiss, D S; Beckwith, J

1997-01-01

FtsI, FtsL, and FtsQ are three membrane proteins required for assembly of the division septum in the bacterium Escherichia coli. Cells lacking any of these three proteins form long, aseptate filaments that eventually lyse. FtsI, FtsL, and FtsQ are not homologous but have similar overall structures: a small cytoplasmic domain, a single membrane-spanning segment (MSS), and a large periplasmic domain that probably encodes the primary functional activities of these proteins. The periplasmic domain of FtsI catalyzes transpeptidation and is involved in the synthesis of septal peptidoglycan. The precise functions of FtsL and FtsQ are not known. To ask whether the cytoplasmic domain and MSS of each protein serve only as a membrane anchor or have instead a more sophisticated function, we have used molecular genetic techniques to swap these domains among the three Fts proteins and one membrane protein not involved in cell division, MalF. In the cases of FtsI and FtsL, replacement of the cytoplasmic domain and/or MSS resulted in the loss of the ability to support cell division. For FtsQ, MSS swaps supported cell division but cytoplasmic domain swaps did not. We discuss several potential interpretations of these results, including that the essential domains of FtsI, FtsL, and FtsQ have a role in regulating the localization and/or activity of these proteins to ensure that septum formation occurs at the right place in the cell and at the right time during the division cycle. PMID:9260951

PKG in honey bees: spatial expression, Amfor gene expression, sucrose responsiveness, and division of labor.

PubMed

Thamm, Markus; Scheiner, Ricarda

2014-06-01

Division of labor is a hallmark of social insects. In honey bees, division of labor involves transition of female workers from one task to the next. The most distinct tasks are nursing (providing food for the brood) and foraging (collecting pollen and nectar). The brain mechanisms regulating this form of behavioral plasticity have largely remained elusive. Recently, it was suggested that division of labor is based on nutrition-associated signaling pathways. One highly conserved gene associated with food-related behavior across species is the foraging gene, which encodes a cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG). Our analysis of this gene reveals the presence of alternative splicing in the honey bee. One isoform is expressed in the brain. Expression of this isoform is most pronounced in the mushroom bodies, the subesophageal ganglion, and the corpora allata. Division of labor and sucrose responsiveness in honey bees correlate significantly with foraging gene expression in distinct brain regions. Activating PKG selectively increases sucrose responsiveness in nurse bees to the level of foragers, whereas the same treatment does not affect responsiveness to light. These findings demonstrate a direct link between PKG signaling in distinct brain areas and division of labor. Furthermore, they demonstrate that the difference in sensory responsiveness between nurse bees and foragers can be compensated for by activating PKG. Our findings on the function of PKG in regulating specific sensory responsiveness and social organization offer valuable indications for the function of the cGMP/PKG pathway in many other insects and vertebrates. Copyright © 2013 Wiley Periodicals, Inc.

The Microanatomic Segregation of Selection by Apoptosis in the Germinal Center

PubMed Central

Mayer, Christian T.; Gazumyan, Anna; Kara, Ervin E.; Gitlin, Alexander D.; Golijanin, Jovana; Viant, Charlotte; Pai, Joy; Oliveira, Thiago Y.; Wang, Qiao; Escolano, Amelia; Medina-Ramirez, Max; Sanders, Rogier W.; Nussenzweig, Michel C.

2018-01-01

B cells undergo rapid cell division and affinity maturation in anatomically distinct sites in lymphoid organs called germinal centers (GCs). Homeostasis is maintained in part by B-cell apoptosis. However, the precise contribution of apoptosis to GC biology and selection is not well defined. We developed apoptosis-indicator mice and used them to visualize, purify, and characterize dying GC B cells. Apoptosis is prevalent in the GC with up to half of all GC B cells dying every 6h. Moreover, programmed cell death is differentially regulated in the light zone (LZ) and the dark zone (DZ): LZ B cells die by default if they are not positively selected, whereas DZ cells die when their antigen receptors are damaged by activation-induced cytidine deaminase (AID). PMID:28935768

Spacelab - Ten years of international cooperation

NASA Technical Reports Server (NTRS)

Bignier, M.; Harrington, J. C.; Sander, M. J.

1983-01-01

The history, current status, and future plans of the Spacelab program are reviewed, with a focus on the cooperative relationship between ESA and NASA. The initial decision to undertake the program and the three agreements signed to begin its implementation are examined, and the division of responsibilities and financial contributions is discussed insofar as it affected the management structure. Consideration is given to the major facilities, the 50-mission operational cycle, communications, the currently scheduled activities (through 1985), the prospective later uses, and the ten dedicated discipline laboratories. The importance of continuous mutual support during the planning and development phases is stressed. The program so far is considered a success, in terms of the goals set by the participants and in terms of the resolution of the problems inherent in international technological endeavors.

Osteoarthritis, labour division, and occupational specialization of the Late Shang China - insights from Yinxu (ca. 1250 - 1046 B.C.).

PubMed

Zhang, Hua; Merrett, Deborah C; Jing, Zhichun; Tang, Jigen; He, Yuling; Yue, Hongbin; Yue, Zhanwei; Yang, Dongya Y

2017-01-01

This research investigates the prevalence of human osteoarthritis at Yinxu, the last capital of the Late Shang dynasty (ca. 1250-1046 B.C.), to gain insights about lifeways of early urban populations in ancient China. A total of 167 skeletal remains from two sites (Xiaomintun and Xin'anzhuang) were analyzed to examine osteoarthritis at eight appendicular joints and through three spinal osseous indicators. High osteoarthritis frequencies were found in the remains with males showing significantly higher osteoarthritis on the upper body (compared to that of the females). This distinctive pattern becomes more obvious for males from Xiaomintun. Furthermore, Xiaomintun people showed significantly higher osteoarthritis in both sexes than those from Xin'anzhuang. Higher upper body osteoarthritis is speculated to be caused by repetitive lifting and carrying heavy-weight objects, disproportionately adding more stress and thus more osseous changes to the upper than the lower body. Such lifting-carrying could be derived from intensified physical activities in general and specialized occupations in particular. Higher osteoarthritis in males may reveal a gendered division of labour, with higher osteoarthritis in Xiaomintun strongly indicating an occupational difference between the two sites. The latter speculation can be supported by the recovery of substantially more bronze-casting artifacts in Xiaomintun. It is also intriguing that relatively higher osteoarthritis was noticed in Xiaomintun females, which seems to suggest that those women might have also participated in bronze-casting activities as a "family business." Such a family-involved occupation, if it existed, may have contributed to establishment of occupation-oriented neighborhoods as proposed by many Shang archaeologists.

Ethnic Minority Psychological Associations and the Society of Counseling Psychology: Greater Connections

ERIC Educational Resources Information Center

Lau, Michael Y.; Forrest, Linda; Delgado-Romero, Edward A.

2012-01-01

This article provides a summary of the Major Contribution on the Ethnic Minority Psychological Associations (Asian American Psychological Association, The Association of Black Psychologists, National Latina/o Psychological Association, Society of Indian Psychologists, and American Psychological Association Division 45) and their connections to…

Educations in Ethnic Violence: Identity, Educational Bubbles, and Resource Mobilization

ERIC Educational Resources Information Center

Lange, Matthew

2011-01-01

In "Educations in Ethnic Violence", Matthew Lange explores the effects education has on ethnic violence. Lange contradicts the widely-held belief that education promotes peace and tolerance. Rather, Lange finds that education commonly contributes to aggression, especially in environments with ethnic divisions, limited resources, and…

CONTRIBUTIONS OF ESTUARINE HABITAT TYPES TO THE ECOLOGICAL INTEGRITY OF A SMALL COVE

EPA Science Inventory

The U.S. EPA, NHEERL, Atlantic Ecology Division, is investigating ecosystem-level approaches to evaluate ecological integrity at multiple scales. The ultimate goal of our project is to develop an ecosystem-level tool to examine impacts of nitrogen pollution on biological integrit...

Young People's Political Participation in the 2011 Parliamentary Elections

ERIC Educational Resources Information Center

Loginova, K.

2014-01-01

Characteristics political behavior among Russian youth can be seen as part of a broader trend toward the erosion of the classical divisions in Russian society. Research shows division between those who support and those who condemn the authorities, and between those who are active users of the Internet and who take part in discussions, and those…

77 FR 27080 - Agency Information Collection Activities; Submission for OMB Review; Comment Request; 2012 Wage...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-08

... for OMB Review; Comment Request; 2012 Wage and Hour Division and Occupational Safety and Health... submitting the information collection request (ICR) proposal titled, ``2012 Wage and Hour Division and... (PRA) of 1995 (44 U.S.C. 3501 et seq.). DATES: Submit comments on or before June 7, 2012. ADDRESSES: A...

33 CFR 211.17 - Authority of Division Engineers, Corps of Engineers to settle claims.

Code of Federal Regulations, 2012 CFR

2012-07-01

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33 CFR 211.17 - Authority of Division Engineers, Corps of Engineers to settle claims.

Code of Federal Regulations, 2013 CFR

2013-07-01

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33 CFR 211.17 - Authority of Division Engineers, Corps of Engineers to settle claims.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Authority of Division Engineers, Corps of Engineers to settle claims. 211.17 Section 211.17 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE REAL ESTATE ACTIVITIES OF THE CORPS OF ENGINEERS IN...

33 CFR 211.17 - Authority of Division Engineers, Corps of Engineers to settle claims.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false Authority of Division Engineers, Corps of Engineers to settle claims. 211.17 Section 211.17 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE REAL ESTATE ACTIVITIES OF THE CORPS OF ENGINEERS IN...

Regulation of DNA synthesis and cell division by polyamines in Catharanthus roseus suspension cultures

Treesearch

R. Minocha; S.C. Minocha; A. Komamine; W.C. Shortle

1991-01-01

Various inhibitors of polyamine biosynthesis were used to study the role of polyamines in DNA synthesis and cell division in suspension cultures of Catharanthus roseus (L) G. Don. Arginine decarboxylase (ADC; EC 4.1.1.19) was the major enzyme responsible for putrescine production. DL α-difluoromethylarginine inhibited ADC activity, cellular...

Division of Labor in German Dual-Earner Families: Testing Equity Theoretical Hypotheses

ERIC Educational Resources Information Center

Klumb, Petra; Hoppmann, Christiane; Staats, Melanie

2006-01-01

On the basis of 52 German dual-earner couples with at least 1 child younger than 5 years, we tested the effects of an unequal division of labor on relationship satisfaction. We analyzed diary reports of time allocated to productive activities according to the actor-partner-interdependence model. Hierarchical linear models showed that rather than…

Active Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial Grants | Division of Cancer Prevention

Cancer.gov

The Division of Cancer Prevention (DCP) conducts and supports research to determine a person's risk of cancer and to find ways to reduce the risk. This knowledge is critical to making progress against cancer because risk varies over the lifespan as genetic and epigenetic changes can transform healthy tissue into invasive cancer.

Organizing. MAS-108. Waste Isolation Division (WID). Management and Supervisor Training (MAST) Program.

ERIC Educational Resources Information Center

Westinghouse Electric Corp., Carlsbad, NM.

This module is part of a set of management and supervisor training (MAST) materials developed by the Department of Energy for the Waste Isolation Division. Its stated purpose is to enable trainees to organize work activities efficiently and effectively. The first section of the module is an introduction that includes a terminal objective and…

Backboards and Browsers: A Qualitative Examination of Division I Student-Athlete Experiences in Online Learning Environments

ERIC Educational Resources Information Center

Healy, Jonathan

2013-01-01

This research explored the experiences of student-athletes in online education. Interviews were conducted with scholarship student-athletes enrolled at a Bowl Championship Series level, Division I institution. Participants had completed at least one online course while actively participating in their sport. A conceptual framework was developed to…

76 FR 5209 - Agency Information Collection Activities; Submission for OMB Review; Comment Request; Information...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-28

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Federal Register 2010, 2011, 2012, 2013, 2014

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Active Alliance of Glycobiologists for Detection of Cancer Grants | Division of Cancer Prevention

Cancer.gov

The Division of Cancer Prevention (DCP) conducts and supports research to determine a person's risk of cancer and to find ways to reduce the risk. This knowledge is critical to making progress against cancer because risk varies over the lifespan as genetic and epigenetic changes can transform healthy tissue into invasive cancer.

Earth Sciences Division annual report 1990

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1991-06-01

This Annual Report presents summaries of selected representative research activities grouped according to the principal disciplines of the Earth Sciences Division: Reservoir Engineering and Hydrogeology, Geology and Geochemistry, and Geophysics and Geomechanics. Much of the Division`s research deals with the physical and chemical properties and processes in the earth`s crust, from the partially saturated, low-temperature near-surface environment to the high-temperature environments characteristic of regions where magmatic-hydrothermal processes are active. Strengths in laboratory and field instrumentation, numerical modeling, and in situ measurement allow study of the transport of mass and heat through geologic media -- studies that now include the appropriatemore » chemical reactions and the hydraulic-mechanical complexities of fractured rock systems. Of particular note are three major Division efforts addressing problems in the discovery and recovery of petroleum, the application of isotope geochemistry to the study of geodynamic processes and earth history, and the development of borehole methods for high-resolution imaging of the subsurface using seismic and electromagnetic waves. In 1989 a major DOE-wide effort was launched in the areas of Environmental Restoration and Waste Management. Many of the methods previously developed for and applied to deeper regions of the earth will in the coming years be turned toward process definition and characterization of the very shallow subsurface, where man-induced contaminants now intrude and where remedial action is required.« less

Two msh/msx-related genes, Djmsh1 and Djmsh2, contribute to the early blastema growth during planarian head regeneration.

PubMed

Mannini, Linda; Deri, Paolo; Gremigni, Vittorio; Rossi, Leonardo; Salvetti, Alessandra; Batistoni, Renata

2008-01-01

Regeneration in planarians is an intriguing phenomenon, based on the presence of pluripotent stem cells, known as neoblasts. Following amputation, these cells activate mitotic divisions, migrate distally and undergo differentiation, giving rise to the regeneration blastema. We have identified two msh/msx-related genes, Djmsh1 and Djmsh2, which are expressed in distinct cell populations of the planarian Dugesia japonica and activated, with different patterns, during head regeneration. We demonstrate that RNA interference of Djmsh1 or Djmsh2 generates a delay in the growth of cephalic blastema, interfering with the dynamics of mitoses during its initial formation. Our data also reveal that the activity of the two planarian msh genes is required to regulate Djbmp expression during head regeneration. This study identifies, for the first time, a functional association between muscle segment homeobox (MSH) homeoproteins and BMP signaling during stem cell-based regeneration of the planarian head and provides a functional analysis of how msh genes may regulate in vivo the regenerative response of planarian stem cells.

Comparison of FDMA and CDMA for second generation land-mobile satellite communications

NASA Technical Reports Server (NTRS)

Yongacoglu, A.; Lyons, R. G.; Mazur, B. A.

1990-01-01

Code Division Multiple Access (CDMA) and Frequency Division Multiple Access (FDMA) (both analog and digital) systems capacities are compared on the basis of identical link availabilities and physical propagation models. Parameters are optimized for a bandwidth limited, multibeam environment. For CDMA, the benefits of voice activated carriers, antenna discrimination, polarization reuse, return link power control and multipath suppression are included in the analysis. For FDMA, the advantages of bandwidth efficient modulation/coding combinations, voice activated carriers, polarization reuse, beam placement, and frequency staggering were taken into account.

Image Sciences Division activities in bldg 8 and 424 for presentation

NASA Image and Video Library

1994-01-25

Views of Image Sciences Division activities in bldg 8 and 424 for use in presentation by George Abbey, Deputy Center Director. Views include Taft Broadcasting employee Dexter Herbert in television editing suite in bldg 8 (26624); RMS Photographic Services employee Kelly St. Germaine at IAMS viewing station in the lobby of bldg 8 (26625); RMS employee Irene Jenkins standing in front of automated files used for negative storage in bldg 424 (26626); RMS employee Irma Rodriguez at barcoding and checkout station in bldg 424 (26627).

Multi-carrier mobile TDMA system with active array antenna

NASA Technical Reports Server (NTRS)

Suzuki, Ryutaro; Matsumoto, Yasushi; Hamamoto, Naokazu

1990-01-01

A multi-carrier time division multiple access (TDMA) is proposed for the future mobile satellite communications systems that include a multi-satellite system. This TDMA system employs the active array antenna in which the digital beam forming technique is adopted to control the antenna beam direction. The antenna beam forming is carried out at the base band frequency by using the digital signal processing technique. The time division duplex technique is applied for the TDM/TDMA burst format, in order not to overlap transmit and receive timing.

CoMIC, the hidden dynamics of mitochondrial inner compartments

PubMed Central

Cho, Bongki; Sun, Woong

2017-01-01

Mitochondria have evolutionarily, functionally and structurally distinct outer- (OMM) and inner-membranes (IMM). Thus, mitochondrial morphology is controlled by independent but coordinated activity of fission and fusion of the OMM and IMM. Constriction and division of the OMM are mediated by endocytosis-like machineries, which include dynamin-related protein 1 with additional cytosolic vesicle scissoring machineries such as actin filament and Dynamin 2. However, structural alteration of the IMM during mitochondrial division has been poorly understood. Recently, we found that the IMM and the inner compartments undergo transient and reversible constriction prior to the OMM division, which we termed CoMIC, Constriction of Mitochondrial Inner Compartment. In this short review, we further discuss the evolutionary perspective and the regulatory mechanism of CoMIC during mitochondrial division. PMID:28803609

CoMIC, the hidden dynamics of mitochondrial inner compartments.

PubMed

Cho, Bongki; Sun, Woong

2017-12-01

Mitochondria have evolutionarily, functionally and structurally distinct outer- (OMM) and inner-membranes (IMM). Thus, mitochondrial morphology is controlled by independent but coordinated activity of fission and fusion of the OMM and IMM. Constriction and division of the OMM are mediated by endocytosis-like machineries, which include dynamin-related protein 1 with additional cytosolic vesicle scissoring machineries such as actin filament and Dynamin 2. However, structural alteration of the IMM during mitochondrial division has been poorly understood. Recently, we found that the IMM and the inner compartments undergo transient and reversible constriction prior to the OMM division, which we termed CoMIC, Constriction of Mitochondrial Inner Compartment. In this short review, we further discuss the evolutionary perspective and the regulatory mechanism of CoMIC during mitochondrial division. [BMB Reports 2017; 50(12): 597-598].

Mothers' perceptions of child care assistance: the impact of a child's disability.

PubMed

Crowe, T K; VanLeit, B; Berghmans, K K

2000-01-01

This study examined and compared mothers' perceptions of child care assistance provided by fathers and other caregivers. Awareness of child care division of labor will assist occupational therapists in addressing the needs of children with disabilities within the family context. One hundred and thirty-five mothers living in two-parent households kept a time diary of their daily activities for 7 consecutive days using the Caregiver's Activity and Recording of Events Inventory and estimated the percentage of child care their partners performed, the amount of child care their partners performed, and their satisfaction with this division of labor. One third of the women had children with multiple disabilities, one third had children with Down syndrome, and one third had children who were typically developing. The majority of mothers in all three groups perceived that they were responsible for the majority of child care. There were no significant differences between groups in terms of mothers' perceptions of the amount of child care provided by fathers and other caregivers, including relatives, childsitters, nurses, school personnel, and neighbors. However, there were wide variations among families concerning child care arrangements and division of labor. Seventy-five percent of mothers indicated that they were satisfied with the division of child care labor between mothers and fathers, and no significant correlation was found between perceived percentage of child care performed and satisfaction with the division of labor. Mothers in this study were responsible for the majority of child care whether their child had a disability. The variation in number of hours that others spent performing child care activities within individual families suggests that there is no "best" or typical pattern. Occupational therapists need to collaborate with families to determine a system of accommodations to manage their daily routine that most effectively meets the family's needs.

Does rational selection of training and test sets improve the outcome of QSAR modeling?

PubMed

Martin, Todd M; Harten, Paul; Young, Douglas M; Muratov, Eugene N; Golbraikh, Alexander; Zhu, Hao; Tropsha, Alexander

2012-10-22

Prior to using a quantitative structure activity relationship (QSAR) model for external predictions, its predictive power should be established and validated. In the absence of a true external data set, the best way to validate the predictive ability of a model is to perform its statistical external validation. In statistical external validation, the overall data set is divided into training and test sets. Commonly, this splitting is performed using random division. Rational splitting methods can divide data sets into training and test sets in an intelligent fashion. The purpose of this study was to determine whether rational division methods lead to more predictive models compared to random division. A special data splitting procedure was used to facilitate the comparison between random and rational division methods. For each toxicity end point, the overall data set was divided into a modeling set (80% of the overall set) and an external evaluation set (20% of the overall set) using random division. The modeling set was then subdivided into a training set (80% of the modeling set) and a test set (20% of the modeling set) using rational division methods and by using random division. The Kennard-Stone, minimal test set dissimilarity, and sphere exclusion algorithms were used as the rational division methods. The hierarchical clustering, random forest, and k-nearest neighbor (kNN) methods were used to develop QSAR models based on the training sets. For kNN QSAR, multiple training and test sets were generated, and multiple QSAR models were built. The results of this study indicate that models based on rational division methods generate better statistical results for the test sets than models based on random division, but the predictive power of both types of models are comparable.

Marking cell lineages in living tissues.

PubMed

Kurup, Smita; Runions, John; Köhler, Uwe; Laplaze, Laurent; Hodge, Sarah; Haseloff, Jim

2005-05-01

We have generated a novel genetic system to visualize cell lineages in living tissues at high resolution. Heat shock was used to trigger the excision of a specific transposon and activation of a fluorescent marker gene. A histone-YFP marker was used to allow identification of cell lineages and easy counting of cells. Constitutive expression of a green fluorescent membrane protein was used to provide a precise outline of all surrounding cells. Marked lineages can be induced from specific cells within the organism by targeted laser irradiation, and the fate of the marked cells can be followed non-invasively. We have used the system to map cell lineages originating from the initials of primary and lateral roots in Arabidopsis. The lineage marking technique enabled us to measure the differential contribution of primary root pericycle cell files to developing lateral root primordia. The majority of cells in an emerging lateral root primordium derive from the central file of pericycle founder cells while off-centre founder cells contribute only a minor proliferation of tissue near the base of the root. The system shows great promise for the detailed study of cell division during morphogenesis.

Electrocatalytic Oxidation of Formate with Nickel Diphosphane Dipeptide Complexes. Effect of Ligands Modified with Amino Acids

DOE Office of Scientific and Technical Information (OSTI.GOV)

Galan, Brandon R.; Reback, Matthew L.; Jain, Avijita

2013-09-03

A series of nickel bis-diphosphine complexes with dipeptides appended to the ligands were investigated for the catalytic oxidation of formate. Typical rates of ~7 s -1 were found, similar to the parent complex (~8 s -1), with amino acid size and positioning contributing very little to rate or operating potential. Hydroxyl functionalities did result in lower rates, which were recovered by protecting the hydroxyl group. The results suggest that the overall dielectric introduced by the dipeptides does not play an important role in catalysis, but free hydroxyl groups do influence activity suggesting contributions from intra- or intermolecular interactions. These observationsmore » are important in developing a fundamental understanding of the affect that an enzyme-like outer coordination sphere can have upon molecular catalysts. This work was funded by the US DOE Basic Energy Sciences, Chemical Sciences, Geoscience and Biosciences Division (BRG, AJ, AMA, WJS), the US DOE Basic Energy Sciences, Physical Bioscience program (MLR). Pacific Northwest National Laboratory is operated by Battelle for the U.S. Department of Energy.« less

Building research and evaluation capacity in population health: the NSW Health approach.

PubMed

Edwards, Barry; Stickney, Beth; Milat, Andrew; Campbell, Danielle; Thackway, Sarah

2016-02-01

Issue addressed An organisational culture that values and uses research and evaluation (R&E) evidence to inform policy and practice is fundamental to improving health outcomes. The 2016 NSW Government Program Evaluation Guidelines recommend investment in training and development to improve evaluation capacity. The purpose of this paper is to outline the approaches taken by the NSW Ministry of Health to develop R&E capacity and assess these against existing models of practice. Method The Ministry of Health's Centre for Epidemiology and Evidence (CEE) takes an evidence-based approach to building R&E capacity in population health. Strategies are informed by: the NSW Population Health Research Strategy, R&E communities of practice across the Ministry and health Pillar agencies and a review of the published evidence on evaluation capacity building (ECB). An internal survey is conducted biennially to monitor research activity within the Ministry's Population and Public Health Division. One representative from each of the six centres that make up the Division coordinates completion of the survey by relevant staff members for their centre. Results The review identified several ECB success factors including: implementing a tailored multifaceted approach; an organisational commitment to R&E; and offering experiential training and ongoing technical support to the workforce. The survey of research activity found that the Division funded a mix of research assets, research funding schemes, research centres and commissioned R&E projects. CEE provides technical advice and support services for staff involved in R&E and in 2015, 22 program evaluations were supported. R&E capacity building also includes a series of guides to assist policy makers, practitioners and researchers to commission, undertake and use policy-relevant R&E. Staff training includes workshops on critical appraisal, program logic and evaluation methods. From January 2013 to June 2014 divisional staff published 84 peer-reviewed papers and one book chapter. Conclusion A strategic approach to R&E capacity building compares favourably with organisational dimensions of ECB and has facilitated the generation of high quality population health R&E in NSW. So what? An evidence-based multistrategy approach to population health R&E can result in substantial contributions to the population-health evidence base.

Technology Development, Evaluation, and Application (TDEA) FY 1998 Progress Report Environment, Safety, and Health (ESH) Division

DOE Office of Scientific and Technical Information (OSTI.GOV)

Larry G. Hoffman; Kenneth Alvar; Thomas Buhl

1999-06-01

This progress report presents the results of 10 projects funded ($504K) in FY98 by the Technology Development, Evaluation, and Application (TDEA) Committee of the Environment, Safety, and Health Division. Nine projects are new for this year; two projects were completed in their third and final TDEA-funded year. As a result of their TDEA-funded projects, investigators have published 19 papers in professional journals, proceedings, or Los Alamos reports and presented their work at professional meetings. Supplemental funds and in-kind contributions, such as staff time, instrument use, and work space were also provided to the TDEA-funded projects by organizations external to ESHmore » Division. Products generated from the projects funded in FY98 included a new extremity dosimeter that replaced the previously used finger-ring dosimeters, a light and easy-to-use detector to measure energy deposited by neutron interactions, and a device that will allow workers to determine the severity of a hazard.« less

Fine Collimator Grids Using Silicon Metering Structure

NASA Technical Reports Server (NTRS)

Eberhard, Carol

1998-01-01

The project Fine Collimator Grids Using Silicon Metering Structure was managed by Dr. Carol Eberhard of the Electromagnetic Systems & Technology Department (Space & Technology Division) of TRW who also wrote this final report. The KOH chemical etching of the silicon wafers was primarily done by Dr. Simon Prussin of the Electrical Engineering Department of UCLA at the laboratory on campus. Moshe Sergant of the Superconductor Electronics Technology Department (Electronics Systems & Technology Division) of TRW and Dr. Prussin were instrumental in developing the low temperature silicon etching processes. Moshe Sergant and George G. Pinneo of the Microelectronics Production Department (Electronics Systems & Technology Division) of TRW were instrumental in developing the processes for filling the slots etched in the silicon wafers with metal-filled materials. Their work was carried out in the laboratories at the Space Park facility. Moshe Sergant is also responsible for the impressive array of Scanning Electron Microscope images with which the various processes were monitored. Many others also contributed their time and expertise to the project. I wish to thank them all.

LGN plays distinct roles in oral epithelial stratification, filiform papilla morphogenesis and hair follicle development

PubMed Central

Lough, Kendall J.; Patel, Jeet H.; Descovich, Carlos Patiño; Curtis, T. Anthony

2016-01-01

Oral epithelia protect against constant challenges by bacteria, viruses, toxins and injury while also contributing to the formation of ectodermal appendages such as teeth, salivary glands and lingual papillae. Despite increasing evidence that differentiation pathway genes are frequently mutated in oral cancers, comparatively little is known about the mechanisms that regulate normal oral epithelial development. Here, we characterize oral epithelial stratification and describe multiple distinct functions for the mitotic spindle orientation gene LGN (Gpsm2) in promoting differentiation and tissue patterning in the mouse oral cavity. Similar to its function in epidermis, apically localized LGN directs perpendicular divisions that promote stratification of the palatal, buccogingival and ventral tongue epithelia. Surprisingly, however, in dorsal tongue LGN is predominantly localized basally, circumferentially or bilaterally and promotes planar divisions. Loss of LGN disrupts the organization and morphogenesis of filiform papillae but appears to be dispensable for embryonic hair follicle development. Thus, LGN has crucial tissue-specific functions in patterning surface ectoderm and its appendages by controlling division orientation. PMID:27317810

Producing 'internal suspect bodies': divisive effects of UK counter-terrorism measures on Muslim communities in Leeds and Bradford.

PubMed

Abbas, Madeline-Sophie

2018-04-06

Research on UK government counter-terrorism measures has claimed that Muslims are treated as a 'suspect community'. However, there is limited research exploring the divisive effects that membership of a 'suspect community' has on relations within Muslim communities. Drawing from interviews with British Muslims living in Leeds or Bradford, I address this gap by explicating how co-option of Muslim community members to counter extremism fractures relations within Muslim communities. I reveal how community members internalize fears of state targeting which precipitates internal disciplinary measures. I contribute the category of 'internal suspect body' which is materialized through two intersecting conditions within preventative counter-terrorism: the suspected extremist for Muslims to look out for and suspected informer who might report fellow Muslims. I argue that the suspect community operates through a network of relations by which terrors of counter-terrorism are reproduced within Muslim communities with divisive effects. © London School of Economics and Political Science 2018.

[The aging process and work: a case study in the maintenance engineering division of a public hospital in the city of São Paulo, Brazil].

PubMed

Sato, Andrea Toshye; Barros, Juliana de Oliveira; Jardim, Tatiana de Andrade; Ratier, Ana Paula Pelegrini; Lancman, Selma

2017-11-06

This study aimed to identify and analyze the relations between aging and work. This was a case study in the maintenance engineering division of a high-complexity hospital in the city of São Paulo, Brazil. In September and October 2015, 16 semi-structured interviews were held with the division heads and other workers with a minimum age of 50 years. The data were analyzed with thematic content analysis. Although the workers experienced difficulties resulting from the aging process, these did not prevent them from performing their work activities, since they developed strategies through their knowhow to compensate for their functional losses and/or declines. Still, they felt limited and demotivated due to the poor working conditions, outsourcing of the division, and the prevailing workload organization. Thus, in this division, the working conditions and organization had more impact than the aging process on the individuals' daily work routine.

MANTECH project book

NASA Astrophysics Data System (ADS)

The effective integration of processes, systems, and procedures used in the production of aerospace systems using computer technology is managed by the Integration Technology Division (MTI). Under its auspices are the Information Management Branch, which is actively involved with information management, information sciences and integration, and the Implementation Branch, whose technology areas include computer integrated manufacturing, engineering design, operations research, and material handling and assembly. The Integration Technology Division combines design, manufacturing, and supportability functions within the same organization. The Processing and Fabrication Division manages programs to improve structural and nonstructural materials processing and fabrication. Within this division, the Metals Branch directs the manufacturing methods program for metals and metal matrix composites processing and fabrication. The Nonmetals Branch directs the manufacturing methods programs, which include all manufacturing processes for producing and utilizing propellants, plastics, resins, fibers, composites, fluid elastomers, ceramics, glasses, and coatings. The objective of the Industrial Base Analysis Division is to act as focal point for the USAF industrial base program for productivity, responsiveness, and preparedness planning.

Cortical PAR polarity proteins promote robust cytokinesis during asymmetric cell division

PubMed Central

Jordan, Shawn N.; Davies, Tim; Zhuravlev, Yelena; Dumont, Julien; Shirasu-Hiza, Mimi

2016-01-01

Cytokinesis, the physical division of one cell into two, is thought to be fundamentally similar in most animal cell divisions and driven by the constriction of a contractile ring positioned and controlled solely by the mitotic spindle. During asymmetric cell divisions, the core polarity machinery (partitioning defective [PAR] proteins) controls the unequal inheritance of key cell fate determinants. Here, we show that in asymmetrically dividing Caenorhabditis elegans embryos, the cortical PAR proteins (including the small guanosine triphosphatase CDC-42) have an active role in regulating recruitment of a critical component of the contractile ring, filamentous actin (F-actin). We found that the cortical PAR proteins are required for the retention of anillin and septin in the anterior pole, which are cytokinesis proteins that our genetic data suggest act as inhibitors of F-actin at the contractile ring. Collectively, our results suggest that the cortical PAR proteins coordinate the establishment of cell polarity with the physical process of cytokinesis during asymmetric cell division to ensure the fidelity of daughter cell formation. PMID:26728855

Polarity, cell division, and out-of-equilibrium dynamics control the growth of epithelial structures

PubMed Central

Cerruti, Benedetta; Puliafito, Alberto; Shewan, Annette M.; Yu, Wei; Combes, Alexander N.; Little, Melissa H.; Chianale, Federica; Primo, Luca; Serini, Guido; Mostov, Keith E.; Celani, Antonio

2013-01-01

The growth of a well-formed epithelial structure is governed by mechanical constraints, cellular apico-basal polarity, and spatially controlled cell division. Here we compared the predictions of a mathematical model of epithelial growth with the morphological analysis of 3D epithelial structures. In both in vitro cyst models and in developing epithelial structures in vivo, epithelial growth could take place close to or far from mechanical equilibrium, and was determined by the hierarchy of time-scales of cell division, cell–cell rearrangements, and lumen dynamics. Equilibrium properties could be inferred by the analysis of cell–cell contact topologies, and the nonequilibrium phenotype was altered by inhibiting ROCK activity. The occurrence of an aberrant multilumen phenotype was linked to fast nonequilibrium growth, even when geometric control of cell division was correctly enforced. We predicted and verified experimentally that slowing down cell division partially rescued a multilumen phenotype induced by altered polarity. These results improve our understanding of the development of epithelial organs and, ultimately, of carcinogenesis. PMID:24145168

Regulation of Asymmetric Division and CD8+ T Lymphocyte Fate Specification by PKCζ and PKCλ/ι

PubMed Central

Metz, Patrick J.; Arsenio, Janilyn; Kakaradov, Boyko; Kim, Stephanie H.; Remedios, Kelly A.; Oakley, Katherine; Akimoto, Kazunori; Ohno, Shigeo; Yeo, Gene W.; Chang, John T.

2015-01-01

During an immune response against a microbial pathogen, activated naïve T lymphocytes give rise to effector cells that provide acute host defense and memory cells that provide long-lived immunity. It has been shown that T lymphocytes can undergo asymmetric division, enabling the daughter cells to inherit unequal amounts of fate-determining proteins and thereby acquire distinct fates from their inception. Here, we show that the absence of the atypical protein kinase C (aPKC) isoforms, PKCζ and PKCλ/ι, disrupts asymmetric CD8+ T lymphocyte division. These alterations were associated with aberrant acquisition of a ‘pre-effector’ transcriptional program, detected by single-cell gene expression analyses, in lymphocytes that had undergone their first division in vivo and enhanced differentiation toward effector fates at the expense of memory fates. Together, these results demonstrate a role for aPKC in regulating asymmetric division and the specification of divergent CD8+ T lymphocyte fates early during an immune response. PMID:25617472

The Contribution of IUPAC to Polymer Science Education

ERIC Educational Resources Information Center

Chan, Chin Han; Fellows, Christopher M.; Hess, Michael; Hiorns, Roger; Hoven, Voravee P.; Russell, Gregory T.; dos Santos, Cla´udio G.; S?turcova´, Adriana; Theato, Patrick

2017-01-01

Polymer education relies on generally agreed terminology and nomenclature rules. The Polymer Division of the International Union of Pure and Applied Chemistry (IUPAC) generates and recommends such rules for naming processes and materials in polymer science. It is the goal of IUPAC that these recommendations be applied in polymer science curricula…

76 FR 4588 - Approval and Promulgation of Air Quality Implementation Plan; Alabama; Disapproval of Interstate...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-26

... Department of Environmental Management (ADEM), provided a letter to EPA with certification that Alabama's... significantly contributing to nonattainment or interfering with the maintenance of the NAAQS in any other state... Branch, Air, Pesticides and Toxics Management Division, U.S. Environmental Protection Agency, Region 4...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Roberto, Jim

The International Union of Pure and Applied Chemistry (IUPAC) Inorganic Chemistry Division has published a Provisional Recommendation for the names and symbols of the recently discovered superheavy elements 113, 115, 117, and 118. Tennessine (Ts) is proposed for element 117, recognizing the contribution of Tennessee research centers ORNL, Vanderbilt and the University of Tennessee to superheavy element research.

Landmark Trials | Division of Cancer Prevention

Cancer.gov

The studies listed below represent the first major clinical trials to evaluate risk reduction for people at high risk of breast, prostate, lung, colorectal, ovarian, cervical, and lung cancer. Analysis of the data gathered from these large trials continues to contribute valuable understanding about related issues, including screening, patient-reported symptoms, quality of

Folate Metabolism and the Risk of Down Syndrome

ERIC Educational Resources Information Center

Patterson, David

2008-01-01

Folate is an important vitamin that contributes to cell division and growth and is therefore of particular importance during infancy and pregnancy. Folate deficiency has been associated with slowed growth, anaemia, weight loss, digestive disorders and some behavioural issues. Adequate folate intake around the time of conception and early pregnancy…

Industry Takes the Initiative.

ERIC Educational Resources Information Center

VocEd, 1983

1983-01-01

The Blackhawk automotive division of Applied Power, Inc. has pioneered a comprehensive nationwide program to train vocational instructors in the new science of unibody auto repair. By training the teachers of auto body technicians, the company increases the value of its equipment while making a contribution to the quality of vocational education.…

Transforming a fourth year modern optics course using a deliberate practice framework

NASA Astrophysics Data System (ADS)

Jones, David J.; Madison, Kirk W.; Wieman, Carl E.

2015-12-01

[This paper is part of the Focused Collection on Upper Division Physics Courses.] We present a study of active learning pedagogies in an upper-division physics course. This work was guided by the principle of deliberate practice for the development of expertise, and this principle was used in the design of the materials and the orchestration of the classroom activities of the students. We present our process for efficiently converting a traditional lecture course based on instructor notes into activities for such a course with active learning methods. Ninety percent of the same material was covered and scores on common exam problems showed a 15% improvement with an effect size greater than 1 after the transformation. We observe that the improvement and the associated effect size is sustained after handing off the materials to a second instructor. Because the improvement on exam questions was independent of specific problem topics and because the material tested was so mathematically advanced and broad (including linear algebra, Fourier transforms, partial differential equations, and vector calculus), we expect the transformation process could be applied to most upper-division physics courses having a similar mathematical base.

Contributions of Academic Emergency Medicine Programs to U.S. Health Care: Summary of the AAAEM-AACEM Benchmarking Data.

PubMed

Reznek, Martin A; Scheulen, James J; Harbertson, Cathi A; Kotkowski, Kevin A; Kelen, Gabor D; Volturo, Gregory A

2018-04-01

The societal contribution of emergency care in the United States has been described. The role and impact of academic emergency departments (EDs) has been less clear. Our report summarizes the results of a benchmarking effort specifically focused on academic emergency medicine (EM) practices. From October through December 2016, the Academy of Academic Administrators of Emergency Medicine (AAAEM) and the Association of Academic Chairs of Emergency Medicine (AACEM) jointly administered a benchmarking survey to allopathic, academic departments and divisions of emergency medicine. Participation was voluntary and nonanonymous. The survey queried various aspects of the three components of the tripartite academic mission: clinical care, education and research, and faculty effort and compensation. Responses reflected a calendar year from July 1, 2015, to June 30, 2016. Of 107 eligible U.S. allopathic, academic departments and divisions of emergency medicine, 79 (74%) responded to the survey overall, although individual questions were not always answered by all responding programs. The 79 responding programs reported 6,876,189 patient visits at 97 primary and affiliated academic clinical sites. A number of clinical operations metrics related to the care of these patients at these sites are reported in this study. All responding programs had active educational programs for EM residents, with a median of 37 residents per program. Nearly half of the overall respondents reported responsibility for teaching medical students in mandatory EM clerkships. Fifty-two programs reported research and publication activity, with a total of $129,494,676 of grant funding and 3,059 publications. Median faculty effort distribution was clinical effort, 66.9%; education effort, 12.7%; administrative effort, 12.0%; and research effort, 6.9%. Median faculty salary was $277,045. Academic EM programs are characterized by significant productivity in clinical operations, education, and research. The survey results reported in this investigation provide appropriate benchmarking for academic EM programs because they allow for comparison of academic programs to each other, rather than nonacademic programs that do not necessarily share the additional missions of research and education and may have dissimilar working environments. © 2017 by the Society for Academic Emergency Medicine.

Regularized two-step brain activity reconstruction from spatiotemporal EEG data

NASA Astrophysics Data System (ADS)

Alecu, Teodor I.; Voloshynovskiy, Sviatoslav; Pun, Thierry

2004-10-01

We are aiming at using EEG source localization in the framework of a Brain Computer Interface project. We propose here a new reconstruction procedure, targeting source (or equivalently mental task) differentiation. EEG data can be thought of as a collection of time continuous streams from sparse locations. The measured electric potential on one electrode is the result of the superposition of synchronized synaptic activity from sources in all the brain volume. Consequently, the EEG inverse problem is a highly underdetermined (and ill-posed) problem. Moreover, each source contribution is linear with respect to its amplitude but non-linear with respect to its localization and orientation. In order to overcome these drawbacks we propose a novel two-step inversion procedure. The solution is based on a double scale division of the solution space. The first step uses a coarse discretization and has the sole purpose of globally identifying the active regions, via a sparse approximation algorithm. The second step is applied only on the retained regions and makes use of a fine discretization of the space, aiming at detailing the brain activity. The local configuration of sources is recovered using an iterative stochastic estimator with adaptive joint minimum energy and directional consistency constraints.

The origins of thalamic inputs to grasp zones in frontal cortex of macaque monkeys

PubMed Central

Stepniewska, Iwona; Kaas, Jon H.

2015-01-01

The hand representation in primary motor cortex (M1) is instrumental to manual dexterity in primates. In Old World monkeys, rostral and caudal aspects of the hand representation are located in the precentral gyrus and the anterior bank of the central sulcus, respectively. We previously reported the organization of the cortico-cortical connections of the grasp zone in rostral M1. Here we describe the organization of thalamocortical connections that were labeled from the same tracer injections. Thalamocortical connections of a grasp zone in ventral premotor cortex (PMv) and the M1 orofacial representation are included for direct comparison. The M1 grasp zone was primarily connected with ventral lateral divisions of motor thalamus. The largest proportion of inputs originated in the posterior division (VLp) followed by the medial and the anterior divisions. Thalamic inputs to the M1 grasp zone originated in more lateral aspects of VLp as compared to the origins of thalamic inputs to the M1 orofacial representation. Inputs to M1 from thalamic divisions connected with cerebellum constituted three fold the density of inputs from divisions connected with basal ganglia, whereas the ratio of inputs was more balanced for the grasp zone in PMv. Privileged access of the cerebellothalamic pathway to the grasp zone in rostral M1 is consistent with the connection patterns previously reported for the precentral gyrus. Thus, cerebellar nuclei are likely more involved than basal ganglia nuclei with the contributions of rostral M1 to manual dexterity. PMID:26254903

The origins of thalamic inputs to grasp zones in frontal cortex of macaque monkeys.

PubMed

Gharbawie, Omar A; Stepniewska, Iwona; Kaas, Jon H

2016-07-01

The hand representation in primary motor cortex (M1) is instrumental to manual dexterity in primates. In Old World monkeys, rostral and caudal aspects of the hand representation are located in the precentral gyrus and the anterior bank of the central sulcus, respectively. We previously reported the organization of the cortico-cortical connections of the grasp zone in rostral M1. Here we describe the organization of thalamocortical connections that were labeled from the same tracer injections. Thalamocortical connections of a grasp zone in ventral premotor cortex (PMv) and the M1 orofacial representation are included for direct comparison. The M1 grasp zone was primarily connected with ventral lateral divisions of motor thalamus. The largest proportion of inputs originated in the posterior division (VLp) followed by the medial and the anterior divisions. Thalamic inputs to the M1 grasp zone originated in more lateral aspects of VLp as compared to the origins of thalamic inputs to the M1 orofacial representation. Inputs to M1 from thalamic divisions connected with cerebellum constituted three fold the density of inputs from divisions connected with basal ganglia, whereas the ratio of inputs was more balanced for the grasp zone in PMv. Privileged access of the cerebellothalamic pathway to the grasp zone in rostral M1 is consistent with the connection patterns previously reported for the precentral gyrus. Thus, cerebellar nuclei are likely more involved than basal ganglia nuclei with the contributions of rostral M1 to manual dexterity.

Grade-related differences in strategy use in multidigit division in two instructional settings.

PubMed

Hickendorff, Marian; Torbeyns, Joke; Verschaffel, Lieven

2017-11-23

We aimed to investigate upper elementary children's strategy use in the domain of multidigit division in two instructional settings: the Netherlands and Flanders (Belgium). A cross-sectional sample of 119 Dutch and 122 Flemish fourth to sixth graders solved a varied set of multidigit division problems. With latent class analysis, three distinct strategy profiles were identified: children consistently using number-based strategies, children combining the use of column-based and number-based strategies, and children combining the use of digit-based and number-based strategies. The relation between children's strategy profiles and their instructional setting (country) and grade were generally in line with instructional differences, but large individual differences remained. Furthermore, Dutch children more frequently made adaptive strategy choices and realistic solutions than their Flemish peers. These results complement and refine previous findings on children's strategy use in relation to mathematics instruction. Statement of contribution What is already known? Mathematics education reform emphasizes variety, adaptivity, and insight in arithmetic strategies. Countries have different instructional trajectories for multidigit division. Mixed results on the impact of instruction on children's strategy use in multidigit division. What does this study add? Latent class analysis identified three meaningful strategy profiles in children from grades 4-6. These strategy profiles substantially differed between children. Dutch and Flemish children's strategy use is related to their instructional trajectory. © 2017 The Authors. British Journal of Developmental Psychology published by John Wiley & Sons Ltd on behalf of British Psychological Society.

Overview of the CERT Resilience Management Model (CERT-RMM)

DTIC Science & Technology

2014-01-23

Management Model (CERT®-RMM) Jim Cebula Technical Manager - Cyber Risk Management , CERT® Division Jim Cebula is the Technical Manager of the...Cyber Risk Management team in the Cyber Security Solutions Directorate of the CERT Division at the Software Engineering Institute (SEI), a unit of...Carnegie Mellon University. Cebula’s current activities include risk management methods along with assessment and management of operational

International Federation of Library Associations Annual Conference Papers. Bibliographic Control Division: Bibliography and Cataloguing Sections (47th, Leipzig, East Germany, August 17-22, 1981).

ERIC Educational Resources Information Center

Vita, Susan H.; And Others

This set of papers delivered to the Bibliographic Control Division of the International Federation of Library Associations (IFLA) during its 47th annual conference (1981) includes: "Cataloging in Publication in the United States--Problems and Prospects," by Susan H. Vita; "Development and Coordination of Bibliographic Activities:…

Fraction Multiplication and Division Word Problems Posed by Different Years of Pre-Service Elementary Mathematics Teachers

ERIC Educational Resources Information Center

Aydogdu Iskenderoglu, Tuba

2018-01-01

It is important for pre-service teachers to know the conceptual difficulties they have experienced regarding the concepts of multiplication and division in fractions and problem posing is a way to learn these conceptual difficulties. Problem posing is a synthetic activity that fundamentally has multiple answers. The purpose of this study is to…

A Guide for Recertification of Ground Based Pressure Vessels and Liquid Holding Tanks

DTIC Science & Technology

1987-12-15

Boiler and Pressure Vessel Code , Section...Requirements 202 Calculate Vessel MAWP Using ASME Boiler and Pressure Vessel Code Section VUI, Division 1. 203 Assess Vessel MAWP Using ASME Boiler and Pressure Vessel Code Section...Engineers (ASME) Boiler and Pressure Vessel Code (B&PV) Section VIll, Division 1, or other applicable standard. This activity involves the

Lawrence A. Oxley and Social Services for Blacks in North Carolina's Appalachian Counties.

ERIC Educational Resources Information Center

Bell, John L.

This paper examines the history of the organization of statewide social services and activities of the Division of Work among Negroes in the Appalachian counties. From 1925-1934--its first 9 years--North Carolina's Division of Work among Negroes was directed by Lawrence Oxley. This agency was established to study black social problems and to help…

A method to generate the surface cell layer of the 3D virtual shoot apex from apical initials.

PubMed

Kucypera, Krzysztof; Lipowczan, Marcin; Piekarska-Stachowiak, Anna; Nakielski, Jerzy

2017-01-01

The development of cell pattern in the surface cell layer of the shoot apex can be investigated in vivo by use of a time-lapse confocal images, showing naked meristem in 3D in successive times. However, how this layer is originated from apical initials and develops as a result of growth and divisions of their descendants, remains unknown. This is an open area for computer modelling. A method to generate the surface cell layer is presented on the example of the 3D paraboloidal shoot apical dome. In the used model the layer originates from three apical initials that meet at the dome summit and develops through growth and cell divisions under the isotropic surface growth, defined by the growth tensor. The cells, which are described by polyhedrons, divide anticlinally with the smallest division plane that passes depending on the used mode through the cell center, or the point found randomly near this center. The formation of the surface cell pattern is described with the attention being paid to activity of the apical initials and fates of their descendants. The computer generated surface layer that included about 350 cells required about 1200 divisions of the apical initials and their derivatives. The derivatives were arranged into three more or less equal clonal sectors composed of cellular clones at different age. Each apical initial renewed itself 7-8 times to produce the sector. In the shape and location and the cellular clones the following divisions of the initial were manifested. The application of the random factor resulted in more realistic cell pattern in comparison to the pure mode. The cell divisions were analyzed statistically on the top view. When all of the division walls were considered, their angular distribution was uniform, whereas in the distribution that was limited to apical initials only, some preferences related to their arrangement at the dome summit were observed. The realistic surface cell pattern was obtained. The present method is a useful tool to generate surface cell layer, study activity of initial cells and their derivatives, and how cell expansion and division are coordinated during growth. We expect its further application to clarify the question of a number and permanence or impermanence of initial cells, and possible relationship between their shape and oriented divisions, both on the ground of the growth tensor approach.

Modeling Mitigation Activities in North Carolina Watersheds

NASA Astrophysics Data System (ADS)

Garcia, A. M.

2017-12-01

Nutrient enrichment and excessive sediment loadings have contributed to the degradation of rivers, lakes and estuaries in North Carolina. The North Carolina Department of Environmental Quality (NCDEQ) has implemented several basin-wide nutrient and sediment management strategies, yet gaps remain in understanding the impact of these strategies given the complexities in quantifying the processes that govern the transport of nutrient and sediment. In particular, improved assessment of the status of nutrient and sediment loadings to lakes and estuaries throughout the state is needed, including characterizing their sources and describing the relative contributions of different areas. The NCDEQ Division of Mitigation Services (DMS) uses watershed planning to identify and prioritize the best locations to implement stream, wetland, and riparian-buffer restoration to improve water quality. To support better decision-making for watershed restoration activities we are developing a SPARROW (SPAtially Referenced Regressions On Watershed attributes) model framework specifically for North Carolina. The SPARROW analysis (developed by the U.S. Geological Survey) relates water-quality monitoring data to better understand the effects of human activities and natural processes on surface-water quality. The core of the model consists of using a nonlinear-regression equation to describe the non-conservative transport of contaminants from point and nonpoint sources on land to rivers, lakes and estuaries through the stream and river network. In this presentation, preliminary total Nitrogen, total Phosphorus, and Total Suspended Solids (TSS) NC-SPARROW models are described that illustrate the SPARROW modeling framework incorporating specific restoration datasets and activity metrics, such as extent of riparian buffer and easements.

LANSCE Activity Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Amy Robinson; Audrey Archuleta; Barbara Maes

1999-02-01

The Los Alamos Neutron Science Center Activity Report describes scientific and technological progress and achievements in LANSCE Division during the period of 1995 to 1998. This report includes a message from the Division Director, an overview of LANSCE, sponsor overviews, research highlights, advanced projects and facility upgrades achievements, experimental and user program accomplishments, news and events, and a list of publications. The research highlights cover the areas of condensed-matter science and engineering, accelerator science, nuclear science, and radiography. This report also contains a compact disk that includes an overview, the Activity Report itself, LANSCE operations progress reports for 1996 andmore » 1997, experiment reports from LANSCE users, as well as a search capability.« less

NOAA's Role in Sustaining Global Ocean Observations: Future Plans for OAR's Ocean Observing and Monitoring Division

NASA Astrophysics Data System (ADS)

Todd, James; Legler, David; Piotrowicz, Stephen; Raymond, Megan; Smith, Emily; Tedesco, Kathy; Thurston, Sidney

2017-04-01

The Ocean Observing and Monitoring Division (OOMD, formerly the Climate Observation Division) of the National Oceanic and Atmospheric Administration (NOAA) Climate Program Office provides long-term, high-quality global observations, climate information and products for researchers, forecasters, assessments and other users of environmental information. In this context, OOMD-supported activities serve a foundational role in an enterprise that aims to advance 1) scientific understanding, 2) monitoring and prediction of climate and 3) understanding of potential impacts to enable a climate resilient society. Leveraging approximately 50% of the Global Ocean Observing System, OOMD employs an internationally-coordinated, multi-institution global strategy that brings together data from multiple platforms including surface drifting buoys, Argo profiling floats, flux/transport moorings (RAMA, PIRATA, OceanSITES), GLOSS tide gauges, SOOP-XBT and SOOP-CO2, ocean gliders and repeat hydrographic sections (GO-SHIP). OOMD also engages in outreach, education and capacity development activities to deliver training on the social-economic applications of ocean data. This presentation will highlight recent activities and plans for 2017 and beyond.

A Model Lightning Safety Policy for Athletics

PubMed Central

Bennett, Brian L.

1997-01-01

Objective: The purpose of this paper is to present a model policy on lightning safety for athletic trainers. Background: Among college athletic programs in the United States there is a serious lack of written policy on lightning safety. Available evidence shows that most National Collegiate Athletic Association (NCAA) Division I institutions, even though they are located in high lightning activity areas of the country, do not have formal, written lightning safety policies. Clinical Advantages/ Recommendations: The policy presented herein, which is at the forefront of such policies, is the lightning safety policy written as part of a policies and procedures manual for the division of sports medicine at a public NCAA Division I university. This is a policy based on practicality that utilizes the “flash-to- bang” method for determining the distance of lightning activity from the observer. The policy begins with the importance of prevention, including the daily monitoring of weather reports. The policy defines a “safe shelter” and specifies the chain of command for determining who removes a team or individuals from an athletic site in the event of dangerous lightning activity. PMID:16558459

The 10th Joint Meeting on Medicinal Chemistry (JMMC 2017) Held in Dubrovnik, Croatia.

PubMed

Perković, Ivana; Stepanić, Višnja; Marković, Vesna Gabelica

2018-01-08

The Croatian Chemical Society was established in 1926 and has developed over the decades into a society that actively supports all chemical activities in Croatia. The Society has eight divisions, the youngest of which, the Division of Medicinal and Pharmaceutical Chemistry, was established in 2012 and immediately became a member of the European Federation of Medicinal Chemistry (EFMC). The mission of the Medicinal and Pharmaceutical Chemistry Division is the promotion and development of scientific, professional, and educational activities within the medicinal chemistry community in Croatia, as well as to build partnerships and collaborations with other primarily EU-based medicinal chemistry societies. In Croatia, medicinal chemistry research is ongoing at several institutes, including the University of Zagreb (Faculty of Science, Faculty of Pharmacy and Biochemistry, and Faculty of Chemical Engineering and Technology), national institutes of science (Ruđer Bošković Institute), and private-sector drug discovery companies (CRO Fidelta Ltd.). In order to effectively exchange knowledge, ideas, and scientific results, Croatian medicinal chemists meet twice annually. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

RanGAP1 is a continuous marker of the Arabidopsis cell division plane

PubMed Central

Xu, Xianfeng Morgan; Zhao, Qiao; Rodrigo-Peiris, Thushani; Brkljacic, Jelena; He, Chao Sylvia; Müller, Sabine; Meier, Iris

2008-01-01

In higher plants, the plane of cell division is faithfully predicted by the preprophase band (PPB). The PPB, a cortical ring of microtubules and F-actin, disassembles upon nuclear-envelope breakdown. During cytokinesis, the expanding cell plate fuses with the plasma membrane at the cortical division site, the site of the former PPB. The nature of the “molecular memory” that is left behind by the PPB and is proposed to guide the cell plate to the cortical division site is unknown. RanGAP is the GTPase activating protein of the small GTPase Ran, which provides spatial information for nucleocytoplasmic transport and various mitotic processes in animals. Here, we show that, in dividing root cells, Arabidopsis RanGAP1 concentrates at the PPB and remains associated with the cortical division site during mitosis and cytokinesis, requiring its N-terminal targeting domain. In a fass/ton2 mutant, which affects PPB formation, RanGAP1 recruitment to the PPB site is lost, while its PPB retention is microtubule-independent. RanGAP1 persistence at the cortical division site, but not its initial accumulation at the PPB requires the 2 cytokinesis-regulating kinesins POK1 and POK2. Depletion of RanGAP by inducible RNAi leads to oblique cell walls and cell-wall stubs in root cell files, consistent with cytokinesis defects. We propose that Arabidopsis RanGAP, a continuous positive protein marker of the plant division plane, has a role in spatial signaling during plant cell division. PMID:19011093

Myosin‑II heavy chain and formin mediate the targeting of myosin essential light chain to the division site before and during cytokinesis

PubMed Central

Feng, Zhonghui; Okada, Satoshi; Cai, Guoping; Zhou, Bing; Bi, Erfei

2015-01-01

MLC1 is a haploinsufficient gene encoding the essential light chain for Myo1, the sole myosin‑II heavy chain in the budding yeast Saccharomyces cerevisiae. Mlc1 defines an essential hub that coordinates actomyosin ring function, membrane trafficking, and septum formation during cytokinesis by binding to IQGAP, myosin‑II, and myosin‑V. However, the mechanism of how Mlc1 is targeted to the division site during the cell cycle remains unsolved. By constructing a GFP‑tagged MLC1 under its own promoter control and using quantitative live‑cell imaging coupled with yeast mutants, we found that septin ring and actin filaments mediate the targeting of Mlc1 to the division site before and during cytokinesis, respectively. Both mechanisms contribute to and are collectively required for the accumulation of Mlc1 at the division site during cytokinesis. We also found that Myo1 plays a major role in the septin‑dependent Mlc1 localization before cytokinesis, whereas the formin Bni1 plays a major role in the actin filament–dependent Mlc1 localization during cytokinesis. Such a two‑tiered mechanism for Mlc1 localization is presumably required for the ordered assembly and robustness of cytokinesis machinery and is likely conserved across species. PMID:25631819

Coordinating Council. Third Meeting: STI Strategic Plans

NASA Technical Reports Server (NTRS)

1990-01-01

The NASA Scientific and Technical Information Program Coordinating Council conducts meetings after which both modified transcripts of presentations and interactive discussions are published. The theme for the November 1990 meeting was 'STI Strategic Plans'. This theme was the focus of recorded discussions by members of the council. The last section of the report presents visuals on strategic goals for the STI Information Division. NASA's vision is to be at the forefront of advancements in aeronautics, space science, and exploration. More specific NASA goals are listed followed by the STI Division mission statement. The Strategic Goals for the STI Division are outlined as follows: Implement effective management strategies, Accomplish rapid deployment of the NASA STI Network, Seek out and develop cooperative partnerships, Establish the STI Program as an integral part of the NASA R&D effort, Enhance the quality of our products and services through a focus on the customer, Build an attitude of quality throughout the enterprise, Expand the existing participant community, Assert a NASA leadership role for STI policy, and Develop a program for information science R&D. The STI division mission statement appears on the document cover as follows 'The mission of the NASA STI Program is to advance aerospace knowledge, contribute to U.S. competitiveness, and become an integral partner in NASA R&D programs to support NASA goals.'

The influence of institutional discourses on the work of informal carers: an institutional ethnography from the perspective of informal carers.

PubMed

Øydgard, Guro Wisth

2017-09-07

The growing numbers of seniors worldwide and the need for support and services that follow from a higher standard of living have led to an increased focus on scarce benefits and limited human resources. At the same time, many western countries have had to make welfare cuts to balance budgets. This has brought the contributions of informal carers to the fore. Thus far, the focus has generally been on the need for the informal carers to receive information and support; to enable them to contribute. The study is designed as an institutional ethnography. The article describes the social processes of informal caregiving and how it interacts with formal caregiving, from the perspective of informal carers. The research question for the study is How do institutional discourses on the work of informal carers influence informal carework? Data for the article comes from qualitative semi-structured interviews with 26 informal carers caring for persons with dementia in Norway, and with 7 administrators working in the allocation divisions of five different municipalities. The results demonstrate how three institutional discourses of informal carers' work influence the allocation divisions' practices and the work of informal carers in caring for their next of kin. The three discourses are categorised as moral and family obligation, shared care and task specificity. The informal carers want to contribute, as they feel a family and moral obligation to their next of kin. In the interaction with the allocation division, they find that the expectation that they will share in the carework and perform specific tasks forces them to perform care within a framework set by the public services. The findings suggest that further research should challenge how services are distributed and allocated rather than focus on how to enable informal carers to fulfil their role better. Because of their moral and family obligation, the informal carers do not have to be forced to perform certain tasks or parts of the shared care. To maintain the informal carers' carework and to fully utilise their contributions, public services would benefit from collaborating with the informal carers to fulfil the total care need of the person with dementia.

Bulletin of the Division of Electrical Engineering, 1987-1988, volume 3, number 2

NASA Astrophysics Data System (ADS)

1988-05-01

A report is provided on the activities of the Division of Electrical Engineering of the National Research Council of Canada. The Division engages in the development of standards and test procedures, and undertakes applied research in support of Canadian industry, government departments, and universities. Technology transfer and collaborative research continue to grow in importance as focuses of Division activities. The Division is comprised of three sections: the Laboratory for Biomedical Engineering, the Laboratory for Electromagnetic and Power Engineering, and the Laboratory for Intelligent Systems. An agreement has been reached to commercially exploit the realtime multiprocessor operating system Harmony. The dielectrics group has made contract research agreements with industry from both Canada and the United States. The possibility of employing a new advanced laser vision camera, which can be mounted on a robot arm in a variety of industrial applications is being explored. Potential short-term spinoffs related to intelligent wheelchairs are being sought as part of the new interlaboratory program which has as its long-term objective the development of a mobile robot for health care applications. A program in applied artificial intelligence has been established. Initiatives in collaboration with outside groups include proposals for major institutes in areas ranging from police and security research to rehabilitation research, programs to enhance Canadian industrial competence working with the Canadian Manufacturers' Association and other government departments, and approaches to the utilization of existing facilities which will make them more valuable without significant financial expenditures.

Fusion Energy Division progress report, 1 January 1990--31 December 1991

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sheffield, J.; Baker, C.C.; Saltmarsh, M.J.

1994-03-01

The Fusion Program of the Oak Ridge National Laboratory (ORNL), a major part of the national fusion program, encompasses nearly all areas of magnetic fusion research. The program is directed toward the development of fusion as an economical and environmentally attractive energy source for the future. The program involves staff from ORNL, Martin Marietta Energy systems, Inc., private industry, the academic community, and other fusion laboratories, in the US and abroad. Achievements resulting from this collaboration are documented in this report, which is issued as the progress report of the ORNL Fusion Energy Division; it also contains information from componentsmore » for the Fusion Program that are external to the division (about 15% of the program effort). The areas addressed by the Fusion Program include the following: experimental and theoretical research on magnetic confinement concepts; engineering and physics of existing and planned devices, including remote handling; development and testing of diagnostic tools and techniques in support of experiments; assembly and distribution to the fusion community of databases on atomic physics and radiation effects; development and testing of technologies for heating and fueling fusion plasmas; development and testing of superconducting magnets for containing fusion plasmas; development and testing of materials for fusion devices; and exploration of opportunities to apply the unique skills, technology, and techniques developed in the course of this work to other areas (about 15% of the Division`s activities). Highlights from program activities during 1990 and 1991 are presented.« less

Neural division of labor in reading is constrained by culture: A training study of reading Chinese characters

PubMed Central

Zhao, Jingjing; Wang, Xiaoyi; Frost, Stephen J.; Sun, Wan; Fang, Shin-Yi; Mencl, W. Einar; Pugh, Kenneth R.; Shu, Hua; Rueckl, Jay G.

2014-01-01

Word reading in alphabetic language involves a cortical system with multiple components whose division of labor depends on the transparency of the writing system. To gain insight about the division of labor between phonology and semantics subserving word reading in Chinese, a deep non-alphabetic writing system, fMRI was used to investigate the effects of phonological and semantic training on the cortical circuitry for oral naming of Chinese characters. In a training study, we examined whether a training task that differentially focused readers' attention on the phonological or semantic properties of a Chinese character changes the patterns of cortical activation that was evoked by that character in a subsequent naming task. Our imaging results corroborate that the cortical regions underlying reading in Chinese largely overlaps the left-hemisphere reading system responsible for reading in alphabetic languages, with some cortical regions in the left-hemisphere uniquely recruited for reading in Chinese. However, in contrast to findings from studies of English word naming, we observed considerable overlap in the neural activation patterns associated with phonological and semantic training on naming Chinese characters, which we suggest may reflect a balanced neural division of labor between phonology and semantics in Chinese character reading. The equitable division of labor for Chinese reading might be driven by the special statistical structure of the writing system, which includes equally systematic mappings in the correspondences between written forms and their pronunciations and meanings. PMID:24607883

Mechanization of Library Procedures in the Medium-sized Medical Library: IX. Holding Statements in PHILSOM: a Study of their Activity *

PubMed Central

Beckwith, Helen K.

1970-01-01

A study was made of the serial holding statements in PHILSOM over a six-month period, in order to determine the desirability of printing the complete serial holding statements monthly. Attention was given to the frequency of internal and update changes in both active and dead entries. The results indicate that while sufficient activity is observed in active serial entries to warrant their monthly updating, dead serial entries remain constant over this period. This indicates that a large group of PHILSOM entries can be easily identified and isolated, facilitating division and independent updating of the resultant lists. The desirability of such a division, however, must also take into consideration the user's ease in handling such a segmented listing. Images PMID:5439902

Mathematics Pentathlon. A Manual of Directions and Official Tournament Rules. Division III. Grades 4-5.

ERIC Educational Resources Information Center

del Regato, John C.; And Others

The Mathematics Pentathlon is a tournament of mathematics games held each spring since 1979 to promote the development of mathematical concepts and skills while fostering interaction among the educational community. There are five games in each of four divisions, for grades K-1, 2-3, 4-5, and 6-7. The focus is on active problem solving and…

Division of Biological and Medical Research annual report, 1979. [Lead abstract

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rosenthal, M.W.

1979-01-01

Separate abstracts were prepared for 14 of the 20 sections included in this progress report. The other 6 sections include: introductory statements by the division director; descriptions of the animal, computer, electron microscope, and radiation support facilities; a listing of the educational activities, divisional seminars, and oral presentations by staff members; and divisional staff publications. An author index to the report is included. (ERB)

Library Development and You. Your Guide to the Programs and Services of the Division of Library Development of the New York State Library.

ERIC Educational Resources Information Center

New York State Library, Albany. Div. of Library Development.

This guide describes the major purposes and activities of the Division of Library Development of the New York State Library. Brief descriptions of the following programs and projects are provided: (1) adult literacy services; (2) central library aid; (3) certification of public librarians; (4) chartering and registration of libraries; (5)…

PDV2 has a dosage effect on chloroplast division in Arabidopsis.

PubMed

Chang, Ning; Sun, Qingqing; Li, Yiqiong; Mu, Yajuan; Hu, Jinglei; Feng, Yue; Liu, Xiaomin; Gao, Hongbo

2017-03-01

PDV2 has a dosage effect on chloroplast division in Arabidopsis thaliana , but this effect may vary in different plants. Chloroplasts have to be divided as plants grow to maintain an optimized number in the cell. Chloroplasts are divided by protein complexes across the double membranes from the stroma side to the cytosolic side. PDV2 is a chloroplast division protein on the chloroplast outer membrane. It recruits the dynamin-related GTPase ARC5 to the division site. The C-terminus of PDV2 and the C-terminus of ARC6 interact in the intermembrane space, which is important for the localization of PDV2. Previously, it was shown that overexpression of PDV2 can increase the division of chloroplasts in Arabidopsis and moss, so the authors concluded that PDV2 determines the rate of chloroplast division in land plants. PDV2 was also shown to inhibit the GTPase activity of ARC5 by in vitro experiment. These results look to be contradictory. Here, we identified a null allele of PDV2 in Arabidopsis and studied plants with different levels of PDV2. Our results suggested that the chloroplast division phenotype in Arabidopsis is sensitive to the level of PDV2, while this is not the case for ARC6. The level of PDV2 protein is reduced sharply in fast-growing leaves, while the level of ARC6 is not. The levels of PDV2 and ARC6 in several other plant species at different developmental stages were also investigated. The results indicated that their expression pattern varies in different species. Thus, PDV2 is an important positive factor of chloroplast division with an apparent dosage effect in Arabidopsis, but this effect for different chloroplast division proteins in different plants may vary.

Timing of Tissue-specific Cell Division Requires a Differential Onset of Zygotic Transcription during Metazoan Embryogenesis*

PubMed Central

Wong, Ming-Kin; Guan, Daogang; Ng, Kaoru Hon Chun; Ho, Vincy Wing Sze; An, Xiaomeng; Li, Runsheng; Ren, Xiaoliang

2016-01-01

Metazoan development demands not only precise cell fate differentiation but also accurate timing of cell division to ensure proper development. How cell divisions are temporally coordinated during development is poorly understood. Caenorhabditis elegans embryogenesis provides an excellent opportunity to study this coordination due to its invariant development and widespread division asynchronies. One of the most pronounced asynchronies is a significant delay of cell division in two endoderm progenitor cells, Ea and Ep, hereafter referred to as E2, relative to its cousins that mainly develop into mesoderm organs and tissues. To unravel the genetic control over the endoderm-specific E2 division timing, a total of 822 essential and conserved genes were knocked down using RNAi followed by quantification of cell cycle lengths using in toto imaging of C. elegans embryogenesis and automated lineage. Intriguingly, knockdown of numerous genes encoding the components of general transcription pathway or its regulatory factors leads to a significant reduction in the E2 cell cycle length but an increase in cell cycle length of the remaining cells, indicating a differential requirement of transcription for division timing between the two. Analysis of lineage-specific RNA-seq data demonstrates an earlier onset of transcription in endoderm than in other germ layers, the timing of which coincides with the birth of E2, supporting the notion that the endoderm-specific delay in E2 division timing demands robust zygotic transcription. The reduction in E2 cell cycle length is frequently associated with cell migration defect and gastrulation failure. The results suggest that a tissue-specific transcriptional activation is required to coordinate fate differentiation, division timing, and cell migration to ensure proper development. PMID:27056332

Arabidopsis ANGUSTIFOLIA3 (AN3) is associated with the promoter of CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1) to regulate light-mediated stomatal development.

PubMed

Meng, Lai-Sheng; Li, Cong; Xu, Meng-Ke; Sun, Xu-Dong; Wan, Wen; Cao, Xiao-Ying; Zhang, Jin-Lin; Chen, Kun-Ming

2018-04-12

Light signals are perceived by multiple photoreceptors that converge to suppress the RING E3 ubiquitin ligase CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1) for the regulation of stomatal development. Thus, COP1 is a point of integration between light signaling and stomatal patterning. However, how light signaling is collected into COP1 for the production and spacing of stomata is still unknown. Here, we report that the loss-of-function mutant of ANGUSTIFOLIA3 (AN3) delays asymmetric cell division, which leads to decreased stomatal index. Furthermore, overexpression of AN3 accelerates asymmetric cell division, which results in clusters of stomata. In addition, the stomatal development through AN3 regulation is mediated by light signaling. Finally, we find that an3 is a light-signaling mutant, and that AN3 protein is light regulated. Self-activation by AN3 contributes to the control of AN3 expression. Thus, AN3 is a point of collection between light signaling and stomatal patterning. Target-gene analysis indicates that AN3 is associated with COP1 promoter for the regulation of light-controlling stomatal development. Together, these components for regulating stomatal development form an AN3-COP1-E3 ubiquitin ligase complex, allowing the integration of light signaling into the production and spacing of stomata. © 2018 John Wiley & Sons Ltd.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

The purpose of this report is to summarize the activities of the Analytical Chemistry Laboratory (ACL) at Argonne National Laboratory (ANL) for Fiscal Year (FY) 1993 (October 1992 through September 1993). This annual report is the tenth for the ACL and describes continuing effort on projects, work on new projects, and contributions of the ACL staff to various programs at ANL. The Analytical Chemistry Laboratory is a full-cost-recovery service center, with the primary mission of providing a broad range of analytical chemistry support services to the scientific and engineering programs at ANL. The ACL also has research programs in analyticalmore » chemistry, conducts instrumental and methods development, and provides analytical services for governmental, educational, and industrial organizations. The ACL handles a wide range of analytical problems. Some routine or standard analyses are done, but it is common for the Argonne programs to generate unique problems that require development or modification of methods and adaption of techniques to obtain useful analytical data. The ACL is administratively within the Chemical Technology Division (CMT), its principal ANL client, but provides technical support for many of the technical divisions and programs at ANL. The ACL has four technical groups--Chemical Analysis, Instrumental Analysis, Organic Analysis, and Environmental Analysis--which together include about 45 technical staff members. Talents and interests of staff members cross the group lines, as do many projects within the ACL.« less

Quantifying T Lymphocyte Turnover

PubMed Central

De Boer, Rob J.; Perelson, Alan S.

2013-01-01

Peripheral T cell populations are maintained by production of naive T cells in the thymus, clonal expansion of activated cells, cellular self-renewal (or homeostatic proliferation), and density dependent cell life spans. A variety of experimental techniques have been employed to quantify the relative contributions of these processes. In modern studies lymphocytes are typically labeled with 5-bromo-2′-deoxyuridine (BrdU), deuterium, or the fluorescent dye carboxy-fluorescein diacetate succinimidyl ester (CFSE), their division history has been studied by monitoring telomere shortening and the dilution of T cell receptor excision circles (TRECs) or the dye CFSE, and clonal expansion has been documented by recording changes in the population densities of antigen specific cells. Proper interpretation of such data in terms of the underlying rates of T cell production, division, and death has proven to be notoriously difficult and involves mathematical modeling. We review the various models that have been developed for each of these techniques, discuss which models seem most appropriate for what type of data, reveal open problems that require better models, and pinpoint how the assumptions underlying a mathematical model may influence the interpretation of data. Elaborating various successful cases where modeling has delivered new insights in T cell population dynamics, this review provides quantitative estimates of several processes involved in the maintenance of naive and memory, CD4+ and CD8+ T cell pools in mice and men. PMID:23313150