SERVING EPA'S MISSION: POTENTIAL ROLES OF ENGERETIC TOOLS

EPA Science Inventory

Effective environmental protection requires an understanding of environmental systems dynamics that includes socioeconomic activity along with its interactions with environmental processes. Some forms of scientific analysis, such as emergy analysis, do seek to account for the ...

76 FR 5802 - Agency Information Collection Activities; Proposed Collection; Comment Request; Cross-Media...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-02

... characters, any form of encryption, and be free of any defects or viruses. For additional information about..., which is designed to: Allow EPA to comply with the Government Paperwork Elimination Act of 1998; provide...

78 FR 13872 - Proposed Information Collection Request; Comment Request; EPA's WaterSense Program (Renewal); EPA...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-01

... profanity, threats, information claimed to be Confidential Business Information (CBI) or other information...-efficient products and use water-efficient practices. As part of strategic planning efforts, EPA encourages... Reporting Form Promotional partners 6100-09 Manufacturers (separate forms for plumbing and non- plumbing...

2002 Toxic Chemical Release Inventory Report for the Emergency Planning and Community Right-to-Know Act of 1986, Title III, Section 313

DOE Office of Scientific and Technical Information (OSTI.GOV)

M. Stockton

2003-11-01

For reporting year 2002, Los Alamos National Laboratory (LANL or the Laboratory) submitted Form R reports for lead compounds and mercury as required under the Emergency Planning and Community Right-to-Know Act (EPCRA), Section 313. No other EPCRA Section 313 chemicals were used in 2002 above the reportable thresholds. This document was prepared to provide a description of the evaluation of EPCRA Section 313 chemical usage and threshold determinations for LANL for calendar year 2002 as well as provide background information about the data included on the Form R reports. Section 313 of EPCRA specifically requires facilities to submit a Toxicmore » Chemical Release Inventory report (Form R) to the U.S. Environmental Protection Agency (EPA) and state agencies if the owners and operators manufacture, process, or otherwise use any of the listed toxic chemicals above listed threshold quantities. EPA compiles this data in the Toxic Release Inventory database. Form R reports for each chemical over threshold quantities must be submitted on or before July 1 each year and must cover activities that occurred at the facility during the previous year. In 1999 EPA promulgated a final rule on Persistent Bioaccumulative Toxics (PBTs). This rule added several chemicals to the EPCRA Section 313 list of toxic chemicals and established lower reporting thresholds for these and other PBT chemicals that were already reportable under EPCRA Section 313. These lower thresholds became applicable in reporting year 2000. In 2001, EPA expanded the PBT rule to include a lower reporting threshold for lead and lead compounds. Facilities that manufacture, process, or otherwise use more than 100 lb of lead or lead compounds must submit a Form R.« less

2006 Toxic Chemical Release Inventory Report for the Emergency Planning and Community Right-to-Know Act of 1986, Title III, Section 313

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ecology and Air Quality Group

2007-12-12

For reporting year 2006, Los Alamos National Laboratory (LANL or the Laboratory) submitted Form R reports for lead as required under the Emergency Planning and Community Right-to-Know Act (EPCRA) Section 313. No other EPCRA Section 313 chemicals were used in 2006 above the reportable thresholds. This document was prepared to provide a description of the evaluation of EPCRA Section 313 chemical use and threshold determinations for LANL for calendar year 2006, as well as to provide background information about data included on the Form R reports. Section 313 of EPCRA specifically requires facilities to submit a Toxic Chemical Release Inventorymore » Report (Form R) to the U.S. Environmental Protection Agency (EPA) and state agencies if the owners and operators manufacture, process, or otherwise use any of the listed toxic chemicals above listed threshold quantities. EPA compiles this data in the Toxic Release Inventory database. Form R reports for each chemical over threshold quantities must be submitted on or before July 1 each year and must cover activities that occurred at the facility during the previous year. In 1999, EPA promulgated a final rule on persistent bioaccumulative toxics (PBTs). This rule added several chemicals to the EPCRA Section 313 list of toxic chemicals and established lower reporting thresholds for these and other PBT chemicals that were already reportable. These lower thresholds became applicable in reporting year 2000. In 2001, EPA expanded the PBT rule to include a lower reporting threshold for lead and lead compounds. Facilities that manufacture, process, or otherwise use more than 100 lb of lead or lead compounds must submit a Form R.« less

2008 Toxic Chemical Release Inventory 2008 Toxic Chemical Release Inventory Community Right-to-Know Act of 1986, Title III, Section 313

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ecology and Air Quality Group

2009-10-01

For reporting year 2008, Los Alamos National Laboratory (LANL) submitted a Form R report for lead as required under the Emergency Planning and Community Right-to- Know Act (EPCRA) Section 313. No other EPCRA Section 313 chemicals were used in 2008 above the reportable thresholds. This document was prepared to provide a description of the evaluation of EPCRA Section 313 chemical use and threshold determinations for LANL for calendar year 2008, as well as to provide background information about data included on the Form R reports. Section 313 of EPCRA specifically requires facilities to submit a Toxic Chemical Release Inventory Reportmore » (Form R) to the U.S. Environmental Protection Agency (EPA) and state agencies if the owners and operators manufacture, process, or otherwise use any of the listed toxic chemicals above listed threshold quantities. EPA compiles this data in the Toxic Release Inventory database. Form R reports for each chemical over threshold quantities must be submitted on or before July 1 each year and must cover activities that occurred at the facility during the previous year. In 1999, EPA promulgated a final rule on persistent bioaccumulative toxics (PBTs). This rule added several chemicals to the EPCRA Section 313 list of toxic chemicals and established lower reporting thresholds for these and other PBT chemicals that were already reportable. These lower thresholds became applicable in reporting year 2000. In 2001, EPA expanded the PBT rule to include a lower reporting threshold for lead and lead compounds. Facilities that manufacture, process, or otherwise use more than 100 lb of lead or lead compounds must submit a Form R.« less

PRN 98-5: New Forms for the Certification with Respect to Citation of Data

EPA Pesticide Factsheets

In 1998, EPA established new forms for citation of data to support the registration or reregistration of pesticide products. These forms are EPA Form 8570-34 (“Certification with Respect to Citation of Data”) and 8570-35 (“Data Matrix”).

48 CFR 1553.209-71 - EPA Form 1900-27, Project Officer's Evaluation of Contractor Performance.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Officer's Evaluation of Contractor Performance. 1553.209-71 Section 1553.209-71 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY CLAUSES AND FORMS FORMS Prescription of Forms 1553.209-71 EPA Form 1900-27, Project Officer's Evaluation of Contractor Performance. As prescribed in 1509.170-4...

Tribal Minor NSR Synthetic Minor Limit Application Form in EPA's South Central Region

EPA Pesticide Factsheets

This Tribal Minor NSR application form should be used to notify the EPA Region 6 Tribal NSR Permitting Program of requested synthetic minor emission limits associated with a new source general application form.

40 CFR 51.40 - In what form and format should my state report the data to EPA?

Code of Federal Regulations, 2011 CFR

2011-07-01

... report the data to EPA? 51.40 Section 51.40 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS REQUIREMENTS FOR PREPARATION, ADOPTION, AND SUBMITTAL OF IMPLEMENTATION PLANS Air... state report the data to EPA? (a) You must report your emission inventory data to us in electronic form...

40 CFR 51.40 - In what form and format should my state report the data to EPA?

Code of Federal Regulations, 2010 CFR

2010-07-01

... report the data to EPA? 51.40 Section 51.40 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS REQUIREMENTS FOR PREPARATION, ADOPTION, AND SUBMITTAL OF IMPLEMENTATION PLANS Air... state report the data to EPA? (a) You must report your emission inventory data to us in electronic form...

Radiation From Solar Activity | Radiation Protection | US EPA

EPA Pesticide Factsheets

2017-08-07

Solar flares, coronal mass ejections (CMEs) and geomagnetic storms from the sun can send extreme bursts of ionizing radiation and magnetic energy toward Earth. Some of this energy is in the form ionizing radiation and some of the energy is magnetic energy.

Confidential Financial Disclosure Form for Environmental Protection Agency Special Government Employees (EPA Form 3110-48)

EPA Pesticide Factsheets

EPA uses the Confidential Financial Disclosure Form to determine whether there is a conflict of interest or the appearance of a lack of impartiality with regard to the topic under review by the FIFRA Scientific Advisory Panel.

Nutritional agents with anti-inflammatory properties in chemoprevention of colorectal neoplasia.

PubMed

Hull, Mark A

2013-01-01

The strong link between inflammation and colorectal carcinogenesis provides the rationale for using anti-inflammatory agents for chemoprevention of colorectal cancer (CRC). Several naturally occurring substances with anti-inflammatory properties, used in a purified 'nutraceutical' form, including omega-3 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic acid (EPA) and polyphenols such as curcumin and resveratrol, have been demonstrated to have anti-CRC activity in preclinical models. As expected, these agents have an excellent safety and tolerability profile in Phase II clinical trials. Phase III randomized clinical trials of these naturally occurring substances are now beginning to be reported. The omega-3 polyunsaturated fatty acid EPA, in the free fatty acid (FFA) form, has been demonstrated to reduce adenomatous polyp number and size in patients with familial adenomatous polyposis (FAP), a finding which has prompted evaluation of this formulation of EPA for prevention of 'sporadic' colorectal neoplasia. Anti-inflammatory 'nutraceuticals' require further clinical evaluation in polyp prevention trials as they exhibit many of the characteristics of the ideal cancer chemoprevention agent, including safety, tolerability and patient acceptability.

40 CFR 7.80 - Applicants.

Code of Federal Regulations, 2011 CFR

2011-07-01

... assistance being provided at the time of the application; and (3) A statement describing any civil rights... assurance with their applications stating that, with respect to their programs or activities that receive... assurance—(i) Real property. When EPA awards assistance in the form of real property, or assistance to...

Formulation of dark chocolate as a carrier to deliver eicosapentaenoic and docosahexaenoic acids: Effects on product quality.

PubMed

Toker, Omer Said; Konar, Nevzat; Palabiyik, Ibrahim; Rasouli Pirouzian, Haniyeh; Oba, Sirin; Polat, Derya Genc; Poyrazoglu, Ender Sinan; Sagdic, Osman

2018-07-15

In this study, dark chocolate enriched with EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) was developed using various forms and origins. Quality characteristics such as physical, thermo-gravimetric, rheological, textural and sensory properties of chocolates were investigated. The highest EPA/DHA stability was determined in samples prepared by free-flowing powder and microencapsulated forms of omega-3 fatty acids (FA). The L ∗ and C ∗ values varied from 32.16-33.37 and 7.45-8.09, respectively for the all samples. Hardness values ranged between 6422 and 8367 N and the use of EPA/DHA in the triglyceride form caused softer chocolate whereas control sample was the hardest sample. Melting and rheological properties were not significantly affected by the studied EPA/DHA sources (P < 0.05). Microencapsulated EPA/DHA added chocolate was the most preferred source whereas sample with algae oil showed the lowest acceptability. According to the results, dark chocolate can be used for delivering omega-3 FA by considering their origin and physical form. Copyright © 2018 Elsevier Ltd. All rights reserved.

Communications Stylebook: Touchpoints

EPA Pesticide Factsheets

A clearly visible EPA logo is the identifier for all forms of media or communications products. Logos and templates for various products can be found on the EPA Graphics Workgroup QuickPlace http://epaquickplace1.rtp.epa.gov/

40 CFR 761.205 - Notification of PCB waste activity (EPA Form 7710-53).

Code of Federal Regulations, 2010 CFR

2010-07-01

... that notifies. (2) All generators (other than generators exempt from notification under paragraph (c)(1... Protection Agency, 1200 Pennsylvania Ave., NW., Washington, DC 20460-0001. Descriptive information and...) Generators (other than those generators exempt from notification under paragraph (c)(1) of this section...

77 FR 73736 - Reports, Forms, and Recordkeeping Requirements: Agency Information Collection Activity Under OMB...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-11

... Fuel Economy (CAFE) standards for light vehicles since 1978 under the statutory authority of the Energy... 19, 2007, amended EPCA and mandated that NHTSA, in consultation with EPA, set fuel economy standards... agency to implement test methods, measurement metrics, fuel economy standards, and compliance and...

78 FR 74127 - Agency Information Collection Activities; Proposed Collection; Comment Request; Land Disposal...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-10

... respond, including through the use of appropriate automated electronic, mechanical, or other technological... necessary to protect human health and the environment. Subsections 3004(d), (e), and (g) require EPA to... its congressional mandate to protect human health and the environment. Form Numbers: None. Respondents...

The activities of acyl-CoA:1-acyl-lysophospholipid acyltransferase(s) in human platelets.

PubMed Central

Bakken, A M; Farstad, M

1992-01-01

The activities of acyl-CoA:1-acyl-lysophospholipid acyltransferases (EC 2.3.1.23) have been studied in human platelet lysates by using endogenously formed [14C]acyl-CoA from [14C]fatty acid, ATP and CoA in the presence of 1-acyl-lysophosphatidyl-choline (lysoPC), -ethanolamine (lysoPE), -serine (lysoPS) or -inositol (lysoPI). Linoleic acid as fatty acid substrate had the highest affinity to acyl-CoA:1-acyl-lysophospholipid acyltransferase with lysoPC as variable substrate, followed by eicosapentaenoic acid (EPA) and arachidonic acid (AA). The activity at optimal conditions was 7.4, 7.3 and 7.2 nmol/min per 10(9) platelets with lysoPC as substrate, with linoleic acid, AA and EPA respectively. EPA and AA were incorporated into all lyso-forms. Linoleic acid was also incorporated into lysoPE at a high rate, but less into lysoPS and lysoPI. DHA was incorporated into lysoPC and lysoPE, but only slightly into lysoPI and lysoPS. Whereas incorporation of all fatty acids tested was maximal for lysoPC and lysoPI at 200 and 80 microM respectively, maximal incorporation needed over 500 microM for lysoPE and lysoPS. The optimal concentration for [14C]fatty acid substrates was in the range 15-150 microM for all lysophospholipids. Competition experiments with equimolar concentrations of either lysoPC and lysoPI or lysoPE resulted in formation of [14C]PC almost as if lysoPI or lysoPE were not added to the assay medium. PMID:1471991

48 CFR 1553.209-70 - EPA Form 1900-26, Contracting Officer's Evaluation of Contractor Performance.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., Contracting Officer's Evaluation of Contractor Performance. 1553.209-70 Section 1553.209-70 Federal... 1553.209-70 EPA Form 1900-26, Contracting Officer's Evaluation of Contractor Performance. As prescribed... evaluation of Contractor performance. ...

Constructing a Shared Mental Model for Faculty Development for the Core Entrustable Professional Activities for Entering Residency.

PubMed

Favreau, Michele A; Tewksbury, Linda; Lupi, Carla; Cutrer, William B; Jokela, Janet A; Yarris, Lalena M

2017-06-01

In 2014, the Association of American Medical Colleges identified 13 Core Entrustable Professional Activities for Entering Residency (Core EPAs), which are activities that entering residents might be expected to perform without direct supervision. This work included the creation of an interinstitutional concept group focused on faculty development efforts, as the processes and tools for teaching and assessing entrustability in undergraduate medical education (UME) are still evolving. In this article, the authors describe a conceptual framework for entrustment that they developed to better prepare all educators involved in entrustment decision making in UME. This framework applies to faculty with limited or longitudinal contact with medical students and to those who contribute to entrustment development or render summative entrustment decisions.The authors describe a shared mental model for entrustment that they developed, based on a critical synthesis of the EPA literature, to serve as a guide for UME faculty development efforts. This model includes four dimensions for Core EPA faculty development: (1) observation skills in authentic settings (workplace-based assessments), (2) coaching and feedback skills, (3) self-assessment and reflection skills, and (4) peer guidance skills developed through a community of practice. These dimensions form a conceptual foundation for meaningful faculty participation in entrustment decision making.The authors also differentiate between the UME learning environment and the graduate medical education learning environment to highlight distinct challenges and opportunities for faculty development in UME settings. They conclude with recommendations and research questions for future Core EPA faculty development efforts.

Update on U.S.EPA Cookstove Research Activities

EPA Science Inventory

The presentation includes background information on EPA's stove research, focuses on cookstove testing for air pollutant emissions and energy efficiency, and briefly describes current research activities. Ongoing activities are highlighted, and EPA contacts are provided.

Using a Curricular Vision to Define Entrustable Professional Activities for Medical Student Assessment.

PubMed

Hauer, Karen E; Boscardin, Christy; Fulton, Tracy B; Lucey, Catherine; Oza, Sandra; Teherani, Arianne

2015-09-01

The new UCSF Bridges Curriculum aims to prepare students to succeed in today's health care system while simultaneously improving it. Curriculum redesign requires assessment strategies that ensure that graduates achieve competence in enduring and emerging skills for clinical practice. To design entrustable professional activities (EPAs) for assessment in a new curriculum and gather evidence of content validity. University of California, San Francisco, School of Medicine. Nineteen medical educators participated; 14 completed both rounds of a Delphi survey. Authors describe 5 steps for defining EPAs that encompass a curricular vision including refining the vision, defining draft EPAs, developing EPAs and assessment strategies, defining competencies and milestones, and mapping milestones to EPAs. A Q-sort activity and Delphi survey involving local medical educators created consensus and prioritization for milestones for each EPA. For 4 EPAs, most milestones had content validity indices (CVIs) of at least 78 %. For 2 EPAs, 2 to 4 milestones did not achieve CVIs of 78 %. We demonstrate a stepwise procedure for developing EPAs that capture essential physician work activities defined by a curricular vision. Structured procedures for soliciting faculty feedback and mapping milestones to EPAs provide content validity.

WASTE REDUCTION ACTIVITIES AND OPTIONS AT A PRINTER OF FORMS AND SUPPLIES FOR THE LEGAL PROFESSION

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) funded a project with the New Jersey Department of Environmental Protection and Energy (NJDEPE) to assist in conducting waste minimization assessments at thirty small-to medium-sized businesses in the state of New Jersey. One of the ...

Tox21: Putting a Lens on the Vision of Toxicity Testing in the 21st Century

EPA Science Inventory

In response to the release of the NRC report on "Toxicity Testing in the 21st Century, a Vision and Strategy" (NRC, 2007), two NIH institutes and EPA formed a collaboration (Tox21) to 1) identify mechanisms of chemically induced biological activity, 2) prioritize chemicals for mo...

Selected Analytical Methods for Environmental Remediation ...

EPA Pesticide Factsheets

The US Environmental Protection Agency’s Office of Research and Development (ORD) conducts cutting-edge research that provides the underpinning of science and technology for public health and environmental policies and decisions made by federal, state and other governmental organizations. ORD’s six research programs identify the pressing research needs with input from EPA offices and stakeholders. Research is conducted by ORD’s 3 labs, 4 centers, and 2 offices located in 14 facilities. The EPA booth at APHL will have several resources available to attendees, mostly in the form of print materials, that showcase our research labs, case studies of research activities, and descriptions of specific research projects. The Selected Analytical Methods for Environmental Remediation and Recovery (SAM), a library of selected methods that are helping to increase the nation's laboratory capacity to support large-scale emergency response operations, will be demoed by EPA scientists at the APHL Experience booth in the Exhibit Hall on Tuesday during the morning break. Please come to the EPA booth #309 for more information! To be on a loop at our ORD booth demo during APHL.

Eicosapentaenoic and docosahexaenoic acid ethyl esters differentially enhance B-cell activity in murine obesity[S

PubMed Central

Teague, Heather; Harris, Mitchel; Fenton, Jenifer; Lallemand, Perrine; Shewchuk, Brian M.; Shaikh, Saame Raza

2014-01-01

EPA and DHA are not biologically equivalent; however, their individual activity on B cells is unknown. We previously reported fish oil enhanced murine B-cell activity in obesity. To distinguish between the effects of EPA and DHA, we studied the ethyl esters of EPA and DHA on murine B-cell function as a function of time. We first demonstrate that EPA and DHA maintained the obese phenotype, with no improvements in fat mass, adipose inflammatory cytokines, fasting insulin, or glucose clearance. We then tested the hypothesis that EPA and DHA would increase the frequency of splenic B cells. EPA and DHA differentially enhanced the frequency and/or percentage of select B-cell subsets, correlating with increased natural serum IgM and cecal IgA. We next determined the activities of EPA and DHA on ex vivo production of cytokines upon lipopolysaccharide stimulation of B cells. EPA and DHA, in a time-dependent manner, enhanced B-cell cytokines with DHA notably increasing IL-10. At the molecular level, EPA and DHA differentially enhanced the formation of ordered microdomains but had no effect on Toll-like receptor 4 mobility. Overall, the results establish differential effects of EPA and DHA in a time-dependent manner on B-cell activity in obesity, which has implications for future clinical studies. PMID:24837990

Analysis of EPA and DHA in the viscera of marine fish using gas chromatography.

PubMed

Zhang, De-Yong; Xu, Xiao-Lu; Shen, Xiu-Ying; Mei, Yu; Xu, Hui-Ying

2016-03-01

The viscera of 10 kinds of marine fishes were collected for fish oil extraction and detection of DHA and EPA, two most important polyunsaturated fatty acids. The fish oil extraction ratio for the evaluated fishes varied from 0.95% to 10.18% (wt%). Pseudosciaena crocea presented the highest fish oil yield, followed by Mustelus manazo, Hippoglossus and Sciaenopsocellatus. A gas chromatography method was then established for analysis of EPA/DHA. The EPA concentration (in methyl ester form) in the fish oil varied from 1.39 to 10.65(mg/g). Epinephelus awoara presented the highest EPA concentration (p<0.05), followed by Epinephelussp, Sciaenopsocellatus and Hippoglossus. The DHA concentration (in methyl ester form) in the fish oil varied from 0.58 to 37.02 (mg/g). Epinephelus awoara presented the highest DHA concentration (p<0.05), followed by Sciaenopsocellatus, Pseudosciaena crocea and Hippoglossus. No strict positive correlation between the EPA/DHA concentration and the sea depth where the fish live was observed. The fishes living in middle depth presented highest EPA/DHA concentration.

EPA Project Updates: DSSTox and ToxCast Generating New ...

EPA Pesticide Factsheets

EPAs National Center for Computational Toxicology is building capabilities to support a new paradigm for toxicity screening and prediction. The DSSTox project is improving public access to quality structure-annotated chemical toxicity information in less summarized forms than traditionally employed in SAR modeling, and in ways that facilitate data-mining, and data read-across. The DSSTox Structure-Browser, launched in September 2007, provides structure searchability across all published DSSTox toxicity-related inventory, and is enabling linkages between previously isolated toxicity data resources. As of early March 2008, the public DSSTox inventory as been integrated into PubChem, allowing a user to take full advantage of PubChem structure-activity and bioassay clustering features. The most recent DSSTox version of Carcinogenic Potency Database file (CPDBAS) illustrates ways in which various summary definitions of carcinogenic activity can be employed in modeling and data mining. Phase I of the ToxCast project is generating high-throughput screening data from several hundred biochemical and cell-based assays for a set of 320 chemicals, mostly pesticide actives, with rich toxicology profiles. Incorporating and expanding traditional SAR Concepts into this new high-throughput and data-rich would pose conceptual and practical challenges, but also holds great promise for improving predictive capabilities. EPA's National Center for Computational Toxicology is bu

DOE Office of Scientific and Technical Information (OSTI.GOV)

Serne, R. Jeffrey; Westsik, Joseph H.; Williams, Benjamin D.

This report describes the results from long-term laboratory leach tests performed at Pacific Northwest National Laboratory (PNNL) for Washington River Protection Solutions (WRPS) to evaluate the release of key constituents from monoliths of Cast Stone prepared with four simulated low-activity waste (LAW) liquid waste streams. Specific objectives of the Cast Stone long-term leach tests described in this report focused on four activities: 1. Extending the leaching times for selected ongoing EPA-1315 tests on monoliths made with LAW simulants beyond the conventional 63-day time period up to 609 days reported herein (with some tests continuing that will be documented later) inmore » an effort to evaluate long-term leaching properties of Cast Stone to support future performance assessment activities. 2. Starting new EPA-1315 leach tests on archived Cast Stone monoliths made with four LAW simulants using two leachants (deionized water [DIW] and simulated Hanford Integrated Disposal Facility (IDF) Site vadose zone pore water [VZP]). 3. Evaluating the impacts of varying the iodide loading (starting iodide concentrations) in one LAW simulant (7.8 M Na Hanford Tank Waste Operations Simulator (HTWOS) Average) by manufacturing new Cast Stone monoliths and repeating the EPA-1315 leach tests using DIW and the VZP leachants. 4. Evaluating the impacts of using a non-pertechnetate form of Tc that is present in some Hanford tanks. In this activity one LAW simulant (7.8 M Na HTWOS Average) was spiked with a Tc(I)-tricarbonyl gluconate species and then solidified into Cast Stone monoliths. Cured monoliths were leached using the EPA-1315 leach protocol with DIW and VZP. The leach results for the Tc-Gluconate Cast Stone monoliths were compared to Cast Stone monoliths pertechnetate.« less

40 CFR 33.205 - How does an entity become certified by EPA?

Code of Federal Regulations, 2010 CFR

2010-07-01

... further information and required application forms to any entity interested in MBE or WBE certification. The applicant must attest to the accuracy and truthfulness of the information on the application form..., if applicable. (b) Application processing. EPA OSDBU will advise each applicant within 15 days...

48 CFR 1553.216-71 - EPA Form 1900-41B, CPAF Contract Individual Performance Event.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Contract Individual Performance Event. 1553.216-71 Section 1553.216-71 Federal Acquisition Regulations... 1900-41B, CPAF Contract Individual Performance Event. As prescribed in 1516.404-278, EPA Form 1900-41B shall be used to document individual performance events under CPAF contracts. ...

Activation of the AMP-Activated Protein Kinase by Eicosapentaenoic Acid (EPA, 20:5 n-3) Improves Endothelial Function In Vivo

PubMed Central

Wu, Yong; Zhang, Cheng; Dong, Yunzhou; Wang, Shuangxi; Song, Ping; Viollet, Benoit; Zou, Ming-Hui

2012-01-01

The aim of the present study was to test the hypothesis that the cardiovascular-protective effects of eicosapentaenoic acid (EPA) may be due, in part, to its ability to stimulate the AMP-activated protein kinase (AMPK)-induced endothelial nitric oxide synthase (eNOS) activation. The role of AMPK in EPA-induced eNOS phosphorylation was investigated in bovine aortic endothelial cells (BAEC), in mice deficient of either AMPKα1 or AMPKα2, in eNOS knockout (KO) mice, or in Apo-E/AMPKα1 dual KO mice. EPA-treatment of BAEC increased both AMPK-Thr172 phosphorylation and AMPK activity, which was accompanied by increased eNOS phosphorylation, NO release, and upregulation of mitochondrial uncoupling protein-2 (UCP-2). Pharmacologic or genetic inhibition of AMPK abolished EPA-enhanced NO release and eNOS phosphorylation in HUVEC. This effect of EPA was absent in the aortas isolated from either eNOS KO mice or AMPKα1 KO mice fed a high-fat, high-cholesterol (HFHC) diet. EPA via upregulation of UCP-2 activates AMPKα1 resulting in increased eNOS phosphorylation and consequent improvement of endothelial function in vivo. PMID:22532857

Eicosapentaenoic acid prevents arterial calcification in klotho mutant mice.

PubMed

Nakamura, Kazufumi; Miura, Daiji; Saito, Yukihiro; Yunoki, Kei; Koyama, Yasushi; Satoh, Minoru; Kondo, Megumi; Osawa, Kazuhiro; Hatipoglu, Omer F; Miyoshi, Toru; Yoshida, Masashi; Morita, Hiroshi; Ito, Hiroshi

2017-01-01

The klotho gene was identified as an "aging-suppressor" gene that accelerates arterial calcification when disrupted. Serum and vascular klotho levels are reduced in patients with chronic kidney disease, and the reduced levels are associated with arterial calcification. Intake of eicosapentaenoic acid (EPA), an n-3 fatty acid, reduces the risk of fatal coronary artery disease. However, the effects of EPA on arterial calcification have not been fully elucidated. The aim of this study was to determine the effect of EPA on arterial calcification in klotho mutant mice. Four-week-old klotho mutant mice and wild-type (WT) mice were given a diet containing 5% EPA (EPA food, klotho and WT: n = 12, each) or not containing EPA (control food, klotho and WT: n = 12, each) for 4 weeks. Calcium volume scores of thoracic and abdominal aortas assessed by computed tomography were significantly elevated in klotho mice after 4 weeks of control food, but they were not elevated in klotho mice after EPA food or in WT mice. Serum levels of EPA and resolvin E1, an active metabolite of EPA, in EPA food-fed mice were significantly increased compared to those in control food-fed mice. An oxidative stress PCR array followed by quantitative PCR revealed that NADPH oxidase-4 (NOX4), an enzyme that generates superoxide, gene expression was up-regulated in arterial smooth muscle cells (SMCs) of klotho mice. Activity of NOX was also significantly higher in SMCs of klotho mice than in those of WT mice. EPA decreased expression levels of the NOX4 gene and NOX activity. GPR120, a receptor of n-3 fatty acids, gene knockdown by siRNA canceled effects of EPA on NOX4 gene expression and NOX activity in arterial SMCs of klotho mice. EPA prevents arterial calcification together with reduction of NOX gene expression and activity via GPR120 in klotho mutant mice.

U.S. EPA'S IRIS ASSESSMENT OF 2-BUTOXYETHANOL: THE RELATIONSHIP OF NONCANCER TO CANCER EFFECTS

EPA Science Inventory

U.S. EPA's current IRIS (Integrated Risk Information System; www.epa.gov/IRIS) assessment of 2-butoxyethanol (EGBE; CASRN 11-76-2) identifies hemolytic effects in laboratory exposed animals as the critical noncancer endpoint. This noncancer (and nonlinear) endpoint forms the b...

2004 Toxic Chemical Release Inventory Report for the Emergency Planning and Community Right-to-Know Act of 1986, Title III, Section 313

DOE Office of Scientific and Technical Information (OSTI.GOV)

M. Stockton

2006-01-15

Section 313 of Emergency Planning and Community Right-to-Know Act (EPCRA) specifically requires facilities to submit a Toxic Chemical Release Inventory Report (Form R) to the U.S. Environmental Protection Agency (EPA) and state agencies if the owners and operators manufacture, process, or otherwise use any of the listed toxic chemicals above listed threshold quantities. EPA compiles this data in the Toxic Release Inventory database. Form R reports for each chemical over threshold quantities must be submitted on or before July 1 each year and must cover activities that occurred at the facility during the previous year. For reporting year 2004, Losmore » Alamos National Laboratory (LANL or the Laboratory) submitted Form R reports for lead compounds, nitric acid, and nitrate compounds as required under the EPCRA Section 313. No other EPCRA Section 313 chemicals were used in 2004 above the reportable thresholds. This document provides a description of the evaluation of EPCRA Section 313 chemical use and threshold determinations for LANL for calendar year 2004, as well as background information about data included on the Form R reports.« less

EPA Form 5700‑52A: United States Environmental Protection Agency Minority Business Enterprise/Woman Business Enterprise Utilization under Federal Grants and Cooperative Agreements

EPA Pesticide Factsheets

MBE/WBE utilization is based on 40 CFR Part 33. EPA Form 5700-52A must be completed by recipients of Federal grants, cooperative agreements, or other Federal financial assistance which involve procurement of supplies, equipment, construction, etc.

40 CFR 60.2235 - In what form can I submit my reports?

Code of Federal Regulations, 2012 CFR

2012-07-01

... opacity data, electronically to EPA's Central Data Exchange (CDX) by using the Electronic Reporting Tool (ERT) (see http://www.epa.gov/ttn/chief/ert/ert tool.html/) or other compatible electronic spreadsheet... Recordkeeping and Reporting § 60.2235 In what form can I submit my reports? Submit initial, annual, and...

40 CFR 60.2235 - In what form can I submit my reports?

Code of Federal Regulations, 2011 CFR

2011-07-01

... opacity data, electronically to EPA's Central Data Exchange (CDX) by using the Electronic Reporting Tool (ERT) (see http://www.epa.gov/ttn/chief/ert/ert tool.html/) or other compatible electronic spreadsheet... Recordkeeping and Reporting § 60.2235 In what form can I submit my reports? Submit initial, annual, and...

75 FR 43520 - Agency Information Collection Activities: Proposed Collection; Comment Request; Information...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-26

...); EPA ICR No. 2400.01 AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: In... numbers: EPA ICR No. 2400.01. ICR status: This ICR is for a new information collection activity. An Agency...

Notification: Review on the Effectiveness of EPA's Environmental Education Activities

EPA Pesticide Factsheets

Project #OPE-FY15-0050, October 16, 2014. The U.S. Environmental Protection Agency (EPA) Office of Inspector General (OIG) plans to begin preliminary research on the effectiveness of the EPA's Environmental Education activities.

Protein kinase A is activated by the n–3 polyunsaturated fatty acid eicosapentaenoic acid in rat ventricular muscle

PubMed Central

Szentandrássy, Norbert; Pérez-Bido, M R; Alonzo, E; Negretti, N; O'Neill, Stephen C

2007-01-01

During cardiac ischaemia antiarrhythmic n–3 polyunsaturated fatty acids (PUFAs) are released following activation of phospholipase A2, if they are in the diet prior to ischaemia. Here we show a positive lusitropic effect of one such PUFA, eicosapentaenoic acid (EPA) in the antiarrhythmic concentration range in Langendorff hearts and isolated rat ventricular myocytes due to activation of protein kinase A (PKA). Several different approaches indicated activation of PKA by EPA (5–10 μmol l−1): the time constant of decay of the systolic Ca2+ transient decreased to 65.3 ± 5.0% of control, Western blot analysis showed a fourfold increase in phospholamban phosphorylation, and PKA activity increased by 21.0 ± 7.3%. In addition myofilament Ca2+ sensitivity was reduced in EPA; this too may have resulted from PKA activation. We also found that EPA inhibited L-type Ca2+ current by 38.7 ± 3.9% but this increased to 63.3 ± 3.4% in 10 μmol l−1 H89 (to inhibit PKA), providing further evidence of activation of PKA by EPA. PKA inhibition also prevented the lusitropic effect of EPA on the systolic Ca2+ transient and contraction. Our measurements show, however, PKA activation in EPA cannot be explained by increased cAMP levels and alternative mechanisms for PKA activation are discussed. The combined lusitropic effect and inhibition of contraction by EPA may, respectively, combat diastolic dysfunction in ischaemic cardiac muscle and promote cell survival by preserving ATP. This is a further level of protection for the heart in addition to the well-documented antiarrhythmic qualities of these fatty acids. PMID:17510185

Redox-Sensitive Induction of Src/PI3-kinase/Akt and MAPKs Pathways Activate eNOS in Response to EPA:DHA 6:1

PubMed Central

Zgheel, Faraj; Alhosin, Mahmoud; Rashid, Sherzad; Burban, Mélanie; Auger, Cyril; Schini-Kerth, Valérie B.

2014-01-01

Aims Omega-3 fatty acid products containing eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have vasoprotective effects, in part, by stimulating the endothelial formation of nitric oxide (NO). This study determined the role of the EPA:DHA ratio and amount, and characterized the mechanism leading to endothelial NO synthase (eNOS) activation. Methods and Results EPA:DHA 6∶1 and 9∶1 caused significantly greater endothelium-dependent relaxations in porcine coronary artery rings than EPA:DHA 3∶1, 1∶1, 1∶3, 1∶6, 1∶9, EPA and DHA alone, and EPA:DHA 6∶1 with a reduced EPA + DHA amount, which were inhibited by an eNOS inhibitor. Relaxations to EPA:DHA 6∶1 were insensitive to cyclooxygenase inhibition, and reduced by inhibitors of either oxidative stress, Src kinase, PI3-kinase, p38 MAPK, MEK, or JNK. EPA:DHA 6∶1 induced phosphorylation of Src, Akt, p38 MAPK, ERK, JNK and eNOS; these effects were inhibited by MnTMPyP. EPA:DHA 6∶1 induced the endothelial formation of ROS in coronary artery sections as assessed by dihydroethidium, and of superoxide anions and hydrogen peroxide in cultured endothelial cells as assessed by electron spin resonance with the spin probe CMH, and the Amplex Red based assay, respectively. Conclusion Omega-3 fatty acids cause endothelium-dependent NO-mediated relaxations in coronary artery rings, which are dependent on the EPA:DHA ratio and amount, and involve an intracellular activation of the redox-sensitive PI3-kinase/Akt and MAPKs pathways to activate eNOS. PMID:25133540

Redox-sensitive induction of Src/PI3-kinase/Akt and MAPKs pathways activate eNOS in response to EPA:DHA 6:1.

PubMed

Zgheel, Faraj; Alhosin, Mahmoud; Rashid, Sherzad; Burban, Mélanie; Auger, Cyril; Schini-Kerth, Valérie B

2014-01-01

Omega-3 fatty acid products containing eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have vasoprotective effects, in part, by stimulating the endothelial formation of nitric oxide (NO). This study determined the role of the EPA:DHA ratio and amount, and characterized the mechanism leading to endothelial NO synthase (eNOS) activation. EPA:DHA 6∶1 and 9∶1 caused significantly greater endothelium-dependent relaxations in porcine coronary artery rings than EPA:DHA 3∶1, 1∶1, 1∶3, 1∶6, 1∶9, EPA and DHA alone, and EPA:DHA 6∶1 with a reduced EPA + DHA amount, which were inhibited by an eNOS inhibitor. Relaxations to EPA:DHA 6∶1 were insensitive to cyclooxygenase inhibition, and reduced by inhibitors of either oxidative stress, Src kinase, PI3-kinase, p38 MAPK, MEK, or JNK. EPA:DHA 6∶1 induced phosphorylation of Src, Akt, p38 MAPK, ERK, JNK and eNOS; these effects were inhibited by MnTMPyP. EPA:DHA 6∶1 induced the endothelial formation of ROS in coronary artery sections as assessed by dihydroethidium, and of superoxide anions and hydrogen peroxide in cultured endothelial cells as assessed by electron spin resonance with the spin probe CMH, and the Amplex Red based assay, respectively. Omega-3 fatty acids cause endothelium-dependent NO-mediated relaxations in coronary artery rings, which are dependent on the EPA:DHA ratio and amount, and involve an intracellular activation of the redox-sensitive PI3-kinase/Akt and MAPKs pathways to activate eNOS.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Evans, V.; Foltz, D.

In 1990, the Clean Air Act was amended amidst a flurry of lobbying. One of the special provisions added was Section 404(d) (see also 40 CFR 72.42) to extend the deadline for compliance under Title IV from 1995 to 1997 for units that committed to install high-efficiency SO{sub 2} scrubbers. Title IV created the Acid Rain Program to reduce emissions of SO{sub 2} and NO{sub x} from electric utility boilers. Section 404(d) was added as a result of the efforts to encourage the continued use of high sulfur coal. Congress allocated 3.5 million allowances for EPA to award under thesemore » provisions. To reduce the uncertainty of being selected to receive extension allowances through EPA`s lottery system, utilities interested in participating in the Program formed the Extension Allowance Pool. The Extension Allowance Pooling Agreement was executed as of March 1992 by 16 utilities. The underlying principle of the Pool is that those utilities whose control units were selected to receive extension allowances would share a portion of those allowances with those Pool participants that were not chosen by EPA. The Pool also provided for the various activities required to implement these arrangements.« less

76 FR 74053 - Agency Information Collection Activities; Proposed Collection; Comment Request; Reporting...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-30

... Activities; Proposed Collection; Comment Request; Reporting Requirements Under EPA's Climate Leaders...: John Sottong, Climate Protection Partnerships Division, Office of Atmospheric Programs, (6202J... Inventory Pilot started during EPA's Climate Leaders Program. Title: Reporting Requirements Under EPA's...

Index to Print Version of EPA Stylebook

EPA Pesticide Factsheets

This EPA Communication Product Standards index provides page numbers for topics such as Ampersands, Bitmapped Graphics, Exhibits and Displays, Podium Signage, Proofing, Sentence Length, Title Page, and Web Forms.

DEVELOPMENT OF AN ETD SURVEILLANCE CHECKLIST FOR MONITORING EPA RESEARCH ACTIVITIES

EPA Science Inventory

DEVELOPMENT OF AN ETD SURVEILLANCE CHECKLIST FOR MONITORING EPA RESEARCH ACTIVITIES, Thomas J. Hughes, National Health and Environmental Effects Research Laboratory (NHEERL), ORD, U.S. EPA, Experimental Toxicology Division (ETD), MD 66, RTP, NC 27711

Research studies condu...

Sample EPA Biotech Form

EPA Pesticide Factsheets

This sample “EPA Biotech Form” is a header sheet that will accompany all biotechnology submission choices, including MCANs, TERAs, Tier I and Tier II exemption, and biotechnology Test Market Exemption Applications (TMEAs).

49 CFR 592.6 - Duties of a registered importer.

Code of Federal Regulations, 2014 CFR

2014-10-01

... insofar as the vehicle has been imported by an Independent Commercial Importer (ICI) who holds a current certificate of conformity with the EPA, the ICI has imported the vehicle under an EPA Declaration form 3520-1 on which Code J is checked, and the EPA has granted the ICI written permission to operate the vehicle...

49 CFR 592.6 - Duties of a registered importer.

Code of Federal Regulations, 2012 CFR

2012-10-01

... conformity, but only insofar as the vehicle has been imported by an Independent Commercial Importer (ICI) who holds a current certificate of conformity with the EPA, the ICI has imported the vehicle under an EPA Declaration form 3520-1 on which Code J is checked, and the EPA has granted the ICI written permission to...

76 FR 43963 - Regional Haze State Implementation Plan; State of Nevada; Extension of Comment Period

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-22

... deadline for written comments on the proposed approval of the Regional Haze SIP by 30 days to August 22... technical materials that form the basis of Nevada's Regional Haze SIP and EPA's proposed approval. The EPA...'s proposed approval of the technical analyses presented in Nevada's plan. DATES: The comment period...

40 CFR 710.59 - Availability of reporting form and instructions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... page. (2) By phone. Call the EPA TSCA Hotline at (202) 554-1404. (3) By e-mail. Send an e-mail request for this information to the EPA TSCA Hotline at TSCA-Hotline@epa.gov. (4) By mail. Send a written request for this information to the following address: TSCA Hotline, Mail Code 7408M, ATTN: Inventory...

Leptin alone and in combination with interleukin-1-beta induced cartilage degradation potentially inhibited by EPA and DHA.

PubMed

Phitak, Thanyaluck; Boonmaleerat, Kanchanit; Pothacharoen, Peraphan; Pruksakorn, Dumnoensun; Kongtawelert, Prachya

2017-09-28

Osteoarthritis (OA) is the most common form of arthritis. Obesity has been believed to be an important risk factor for OA development and the progression of not only load-bearing joints, but low-load-bearing joints as well. Increased leptin has been the focus of a link between obesity and OA. In this study, the effects of pathological (100ng/ml) or supra-pathological (10μg/ml) concentrations of leptin alone or in combination with IL1β on cartilage metabolisms were studied in porcine cartilage explant. The involved mechanisms were examined in human articular chondrocytes (HACs). Moreover, the protective effect of omega-3 polyunsaturated acids, eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) was also investigated. Leptin (10μg/ml) alone or in combination with IL1β could induce cartilage destruction, although lower concentrations had no effect. Leptin activated NFκB, ERK, JNK and p38 in HACs, which led to the induction of MMP3, MMP13 and ADAMTS4 secretions. The combined effect could further induce those enzymes through the additive effect on activation of NFκB and JNK. Interestingly, both EPA and DHA could inhibit cartilage damage induced by leptin plus IL1β by reducing the activation of NFκB and JNK, which led to the decrease of ADAMTS4 secretion. Altogether, only a supra-pathological concentration of leptin alone or in combination with IL1β could induce cartilage destruction, whereas a pathological one could not. This effect could be inhibited by EPA and DHA. To gain greater understanding of the link between leptin and OA, the effect of different levels of leptin on several states of OA cartilage requires further investigation.

77 FR 38051 - EPA Activities To Promote Environmental Justice in the Permit Application Process

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-26

... (EPA). In 2011, EPA published Plan EJ 2014, the Agency's overarching strategy for advancing... robust community engagement strategies that recognize the value of community outreach. Pursuant to these strategies, facilities engage actively with the community through environmental initiatives, neighborhood...

Overview of EPA activities and research related to black carbon

EPA Science Inventory

The purpose of this international presentation is to give an overview of EPA activities related to black carbon (BC). This overview includes some summary information on how EPA defines BC, current knowledge on United States emissions and forecasted emission reductions, and ongoin...

76 FR 81488 - Agency Information Collection Activities; Proposed Collection; Comment Request; National...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-28

... Activities; Proposed Collection; Comment Request; National Pollutant Discharge Elimination System (NPDES... viruses. For additional information about EPA's public docket, visit the EPA Docket Center homepage at... Pollutant Discharge Elimination System (NPDES) Program (Renewal). ICR Number: EPA ICR No. 0229.20, OMB...

EPA Scientific Knowledge Management Assessment and Needs

EPA Science Inventory

A series of activities have been conducted by a core group of EPA scientists from across the Agency. The activities were initiated in 2012 and the focus was to increase the reuse and interoperability of science software at EPA. The need for increased reuse and interoperability ...

76 FR 60020 - Agency Information Collection Activities: Proposed Collection; Comment Request; Ambient Air...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-28

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OAR-2002-0091, FRL-9472-8] Agency Information Collection Activities: Proposed Collection; Comment Request; Ambient Air Quality Surveillance AGENCY: Environmental... . Fax: (202) 566-1741. Mail: Environmental Protection Agency, EPA Docket Center (EPA/DC), Air and...

76 FR 50726 - Agency Information Collection Activities; Proposed Collection; Comment Request; EPA Strategic...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-16

... Activities; Proposed Collection; Comment Request; EPA Strategic Plan Information on Source Water Protection... submitting comments. E-mail: [email protected] . Mail: Water Docket, Environmental Protection Agency, EPA.../epahome/dockets.htm . FOR FURTHER INFORMATION CONTACT: Beth Hall, Drinking Water Protection Division...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, Hyeon Ho; Lee, Youngae; Laboratory of Cutaneous Aging Research, Department of Dermatology, Clinical Research Institutes, Seoul National University Hospital, 28 Yongon-dong, Jongno-gu, Seoul 110-744

Eicosapentaenoic acid (EPA) is an omega-3 ({omega}-3) polyunsaturated fatty acid (PUFA), which has anti-inflammatory and anti-cancer properties. Some reports have demonstrated that EPA inhibits NF-{kappa}B activation induced by tumor necrosis factor (TNF)-{alpha} or lipopolysaccharide (LPS) in various cells. However, its detailed mode of action is unclear. In this report, we investigated whether EPA inhibits the expression of TNF-{alpha}-induced matrix metalloproteinases (MMP)-9 in human immortalized keratinocytes (HaCaT). TNF-{alpha} induced MMP-9 expression by NF-{kappa}B-dependent pathway. Pretreatment of EPA inhibited TNF-{alpha}-induced MMP-9 expression and p65 phosphorylation. However, EPA could not affect I{kappa}B-{alpha} phosphorylation, nuclear translocation of p65, and DNA binding activity of NF-{kappa}B.more » EPA inhibited TNF-{alpha}-induced p65 phosphorylation through p38 and Akt inhibition and this inhibition was IKK{alpha}-dependent event. Taken together, we demonstrate that EPA inhibits TNF-{alpha}-induced MMP-9 expression through inhibition of p38 and Akt activation.« less

EPA Region 9 Targeted Brownfields Assessment (TBA) Application

EPA Pesticide Factsheets

EPA provides contractor assistance for property assessment to determine eligibility for up to $100,000 worth of technical assistance. Use this assessment form for properties in Arizona, California, Nevada, and Hawaii.

75 FR 14150 - Agency Information Collection Activities; Proposed Collection; Comment Request; Request for...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-24

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPPT-2009-0929; FRL-8806-1] Agency Information Collection Activities; Proposed Collection; Comment Request; Request for Contractor Access to TSCA CBI; EPA ICR No. 1250.09, OMB Control No. 2070-0075 AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY...

75 FR 8694 - Agency Information Collection Activities; Proposed Collection; Comment Request; Animal Sectors...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-25

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OW-2008-0719, FRL-9118-2] Agency Information Collection Activities; Proposed Collection; Comment Request; Animal Sectors; EPA ICR No. 1989.07; OMB Control No. 2040-0250 AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: In compliance with the...

78 FR 73522 - Agency Information Collection Activities: Submission to OMB for Review and Approval; State Review...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-06

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OECA-2010-0291; FRL- 9903-87-OEI] Agency Information Collection Activities: Submission to OMB for Review and Approval; State Review Framework; EPA ICR Number 2185.05 AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: In compliance with the...

77 FR 4297 - Agency Information Collection Activities; Proposed Collection; Comment Request; Reporting Under...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-27

... Activities; Proposed Collection; Comment Request; Reporting Under EPA's Landfill Methane Outreach Program...; and other landfill gas energy stakeholders. Title: Reporting Under EPA's Landfill Methane Outreach... Landfill Methane Outreach Program (LMOP), created by EPA as part of the Climate Change Action Plan, is a...

76 FR 20661 - Agency Information Collection Activities; Proposed Collection; Comment Request; Contractor...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-13

... Activities; Proposed Collection; Comment Request; Contractor Conflicts of Interest AGENCY: Environmental....regulations.gov . Title: Contractor Conflicts of Interest. ICR numbers: EPA ICR No. 1550.09, OMB Control No... control numbers in certain EPA regulations is consolidated in 40 CFR part 9. Abstract: EPA contractors...

A comparative study: In vitro effects of EPA and DHA on immune functions of head-kidney macrophages isolated from large yellow croaker (Larmichthys crocea).

PubMed

Li, Qingfei; Ai, Qinghui; Mai, Kangsen; Xu, Wei; Zheng, Yuefu

2013-09-01

Comparative effects of different concentrations of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on immune responses of head-kidney macrophages isolated from large yellow croaker were studied in vitro. After exposing to serum-free medium for 1 day, cultured cells were incubated in medium supplemented with graded levels of EPA or DHA (0, 5, 25, 100, 200 and 1000 μM, respectively) in the form of fatty acid bovine serum albumin (FA-BSA) complex for 12 h, 24 h and 36 h, respectively. Control samples were incubated in the absence of EPA or DHA (2% bovine serum albumin, BSA). Following stimulation, cell viability, lipid peroxidation, secretary phopholipase A2 (sPLA2) and prostaglandin E2 (PGE2) production as well as some immune parameters including phagocytosis, respiratory burst activity and interleukin 1β (IL-1β) production were determined. Results showed that EPA and DHA affected cell viability in dose-dependent and time-dependent manners. In particular, cell viability was significantly decreased after 24 h and 36 h incubation with 1000 μM EPA or DHA (P < 0.05). Higher levels of EPA (200 and 1000 μM) caused a significant increase in the production of malondialdehyde (MDA) (P < 0.05), while DHA did not significantly affect the MDA production. EPA significantly increased the intracellular superoxide anion synthesis which, on the contrary, was significantly reduced by DHA. Phagocytosis percentage (PP) values were significantly higher in treatments with 5 μM DHA (P < 0.05), but significantly decreased by 200 and 1000 μM EPA and DHA compared to the control group (P < 0.05). Decreased PGE2 production was produced by cells treated with relatively low doses of EPA or DHA. When high levels of stimulants (1000 μM EPA or DHA) were used, PGE2 levels were elevated and reached a significant level (P < 0.05). Both EPA and DHA significantly inhibited the production of sPLA2, where DHA exerted the more potent inhibitory effects than EPA. No pronounced effect was observed on IL-1β production among all the treatments, and IL-1β level in cell culture supernatant was fairly low (only approximately 6 pg/ml). Those findings suggested that EPA and DHA could influence the immunity and physiological conditions of macrophages from head kidney of large yellow croaker in vitro. Copyright © 2013. Published by Elsevier Ltd.

Mechanism of Growth Inhibition of Human Cancer Cells by Conjugated Eicosapentaenoic Acid, an Inhibitor of DNA Polymerase and Topoisomerase

PubMed Central

Yonezawa, Yuko; Yoshida, Hiromi; Mizushina, Yoshiyuki

2007-01-01

DNA topoisomerases (topos) and DNA polymerases (pols) are involved in many aspects of DNA metabolism such as replication reactions. We found that long chain unsaturated fatty acids such as polyunsaturated fatty acids (PUFA) (i.e., eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)) inhibited the activities of eukaryotic pols and topos in vitro, and the inhibitory effect of conjugated fatty acids converted from EPA and DHA (cEPA and cDHA) on pols and topos was stronger than that of normal EPA and DHA. cEPA and cDHA did not affect the activities of plant and prokaryotic pols or other DNA metabolic enzymes tested. cEPA was a stronger inhibitor than cDHA with IC50 values for mammalian pols and human topos of 11.0 – 31.8 and 0.5 – 2.5 μM, respectively. cEPA inhibited the proliferation of two human leukemia cell lines, NALM-6, which is a p53-wild type, and HL-60, which is a p53-null mutant, and the inhibitory effect was stronger than that of normal EPA. In both cell lines, cEPA arrested in the G1 phase, and increased cyclin E protein levels, indicating that it blocks the primary step of in vivo DNA replication by inhibiting the activity of replicative pols rather than topos. DNA replication-related proteins, such as RPA70, ATR and phosphorylated-Chk1/2, were increased by cEPA treatment in the cell lines, suggesting that cEPA led to DNA replication fork stress inhibiting the activities of pols and topos, and the ATR-dependent DNA damage response pathway could respond to the inhibitor of DNA replication. The compound induced cell apoptosis through both p53-dependent and p53-independent pathways in cell lines NALM-6 and HL-60, respectively. These results suggested the therapeutic potential of conjugated PUFA, such as cEPA, as a leading anti-cancer compound that inhibited pols and topos activities.

75 FR 51434 - Hazardous and Solid Waste Management System; Identification and Listing of Special Wastes...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-20

... characters, any form of encryption, and be free of any defects or viruses. For additional information about... hearings can be found on EPA's Web site at: http://www.epa.gov/epawaste/nonhaz/industrial/special/fossil... information on the Web site: http://www.epa.gov/osw/nonhaz/industrial/special/fossil/ccr-rule/ccr-webinar.htm...

77 FR 15753 - Request for Nominations of Experts for a Science Advisory Board Panel To Review EPA's Web-Based...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-16

... Advisory Board Panel To Review EPA's Web-Based Report on the Environment AGENCY: Environmental Protection... nominations of technical experts to form an SAB panel to review the Agency's Web-based Report on the... procedural policies. EPA's Web-based Report on the Environment (ROE) has been developed to provide a...

40 CFR 1027.130 - How do I make a fee payment?

Code of Federal Regulations, 2013 CFR

2013-07-01

... method available for payment online at www.Pay.gov., or as specified in EPA guidance. (b) Send a... www.Pay.gov., or as provided in EPA guidance. These forms are available on the Internet at http://www.epa.gov/otaq/guidance.htm. (c) You must pay the fee amount due before we will start to process an...

40 CFR 1027.130 - How do I make a fee payment?

Code of Federal Regulations, 2010 CFR

2010-07-01

... method available for payment online at www.Pay.gov., or as specified in EPA guidance. (b) Send a... www.Pay.gov., or as provided in EPA guidance. These forms are available on the Internet at http://www.epa.gov/otaq/guidance.htm. (c) You must pay the fee amount due before we will start to process an...

A comparative study of EPA-enriched ethanolamine plasmalogen and EPA-enriched phosphatidylethanolamine on Aβ42 induced cognitive deficiency in a rat model of Alzheimer's disease.

PubMed

Che, Hongxia; Li, Qian; Zhang, Tiantian; Ding, Lin; Zhang, Lingyu; Shi, Haohao; Yanagita, Teruyoshi; Xue, Changhu; Chang, Yaoguang; Wang, Yuming

2018-05-23

Ethanolamine plasmalogen (pPE), a major phospholipid in neuronal membranes, is specifically reduced in postmortem brains from patients with Alzheimer's disease (AD). The purpose of the present study was to compare the effects of EPA-enriched ethanolamine plasmalogen (EPA-pPE) and EPA-enriched phosphatidylethanolamine (EPA-PE) on cognitive deficiency and illustrate the possible underlying mechanisms. SD rats were divided into four groups including the sham group injected with 0.9% saline and three amyloid-β (Aβ) infusion groups, Aβ42 group, EPA-pPE group and EPA-PE group. EPA-pPE and EPA-PE were administered by gavage (150 mg kg-1 day-1), respectively, once a day for 26 days. Administration of EPA-pPE exerted better effects than EPA-PE in improving Aβ-induced cognitive deficiency in a rat model of Alzheimer's disease. Further mechanical research indicated that EPA-pPE was superior to EPA-PE in regulating oxidative stress via increasing SOD activity and decreasing MDA level, as well as reducing GSK-3β and tau phosphorylation. Moreover, EPA-PE was more effective than EPA-pPE at inhibiting the protein expressions of Bax and caspase 9. The results of neuro-inflammation and inflammasome activation showed that EPA-pPE exerted more significant effects than EPA-PE in inhibiting the expressions of TNF-α and IL-1β, and decreasing NLRP3, pro-caspase 1 and caspase 1 levels. EPA-pPE alleviated Aβ-induced neurotoxicity by inhibiting oxidative stress, neuronal injury, apoptosis and neuro-inflammation, which might depend on the vinyl ether linkage at the sn-1 position.

78 FR 36775 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-19

... EPA-HQ-OECA-2012-0660, which is available for either public viewing online at http://www.regulations.gov , or in person viewing at the Enforcement and Compliance Docket in the EPA Docket Center (EPA/ DC), EPA West, Room 3334, 1301 Constitution Avenue NW., Washington, DC. The EPA Docket Center Public...

Everyday Physical Activity as a Predictor of Late-Life Mortality

ERIC Educational Resources Information Center

Chipperfield, Judith G.

2008-01-01

Purpose: The present study hypothesized that simple, everyday physical activity (EPA) would decline with advancing age; that women would have a more favorable EPA profile than would men; and that EPA would have a survival benefit. Design and Methods: Community-dwelling participants (aged 80-98 years, n = 198) wore mechanical actigraphs in order…

76 FR 62400 - Agency Information Collection Activities; Proposed Collection; Comment Request; Focus Groups as...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-07

... Activities; Proposed Collection; Comment Request; Focus Groups as Used by EPA for Economics Projects (Renewal... used by EPA for Economics Projects (Renewal). ICR numbers: EPA ICR No. 2205.07, OMB Control No. 2090... interviews (hereafter jointly referred to as focus groups) related to economics projects. Over the next three...

75 FR 44944 - Agency Information Collection Activities; Proposed Collection; Comment Request; Environmental...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-30

... Nongovernmental Activities in Antarctica; EPA ICR No. 1808.06, OMB Control No. 2020- 0007 AGENCY: Environmental..., which means EPA will not know your identity or contact information unless you provide it in the body of... ``search,'' then key in the docket ID number identified in this document. What information is EPA...

76 FR 59696 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-27

... Activities; Submission to OMB for Review and Approval; Comment Request; Exchange Network Grants Progress...: Exchange Network Grants Progress Reports (Renewal). ICR Numbers: EPA ICR No. 2207.04, OMB Control No. 2025... Network (NEIEN) Grant Program. The EPA Office of Environmental Information provides funding to EPA's...

Eicosapentaenoic acid abolishes inhibition of insulin-induced mTOR phosphorylation by LPS via PTP1B downregulation in skeletal muscle.

PubMed

Wei, Hong-Kui; Deng, Zhao; Jiang, Shu-Zhong; Song, Tong-Xing; Zhou, Yuan-Fei; Peng, Jian; Tao, Ya-Xiong

2017-01-05

Dietary n-3 polyunsaturated fatty acids (n-3 PUFAs) increase insulin signaling in skeletal muscle. In the current study, we investigated the effect of eicosapentaenoic acid (EPA) on insulin-induced mammalian target of rapamycin (mTOR) phosphorylation in myotubes. We showed that EPA did not affect basal and insulin-induced mTOR phosphorylation in myotubes. However, EPA abolished lipopolysaccharide (LPS) -induced deficiency in insulin signaling (P < 0.05). Pre-incubation of nuclear factor κB (NF-κΒ) and c-Jun N-terminal kinases (JNK) inhibitors prevented the decreased insulin-induced mTOR phosphorylation elicited by LPS (P < 0.05). In addition, in protein tyrosine phosphatase-1B (PTP1B) knockdown myotubes, LPS failed to decrease insulin-induced mammalian target of rapamycin (mTOR) phosphorylation in myotubes (P > 0.05). In myotubes, LPS stimulated PTP1B expression via NF-κB and activation protein-1 (AP1). Pre-incubation of 50 μM EPA prevented the LPS-induced activation of AP1 and NF-κΒ as well as PTP1B expression (P < 0.05). Interestingly, incubation of peroxisome proliferator-activated receptor γ (PPARγ) antagonist (GW9662) prior to EPA treatment, the effect of EPA on insulin-induced mTOR phosphorylation was blocked. Accordingly, EPA did not inhibit the LPS-induced activation of AP1 or NF-κΒ as well as PTP1B expression when incubation of GW9662 prior to EPA treatment. The in vivo study showed that EPA prevented LPS-induced PTPT1B expression and a decrease in insulin-induced mTOR phosphorylation in muscle of mice. In summary, EPA abolished LPS inhibition of insulin-induced mTOR phosphorylation in myotubes, and one of the key mechanisms was to inhibit AP1 and NF-κB activation and PTP1B transcription. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

MAG-EPA reduces severity of DSS-induced colitis in rats.

PubMed

Morin, Caroline; Blier, Pierre U; Fortin, Samuel

2016-05-15

Ulcerative colitis (UC) is a chronic disease characterized by diffuse inflammation of the intestinal mucosa of the large bowel. Omega-3 (ω3) fatty acid supplementation has been associated with a decreased production of inflammatory cytokines involved in UC pathogenesis. The aim of this study was to determine the preventive and therapeutic potential of eicosapentaenoic acid monoglyceride (MAG-EPA) in an in vivo rats model of UC induced by dextran sulfate sodium (DSS). DSS rats were untreated or treated per os with MAG-EPA. Morphological, histological, and biochemical analyses were performed following MAG-EPA administrations. Morphological and histological analyses revealed that MAG-EPA pretreatment (12 days pre-DSS) and treatment (6 days post-DSS) exhibited strong activity in reducing severity of disease in DSS rats. Following MAG-EPA administrations, tissue levels of the proinflammatory cytokines TNF-α, IL-1β, and IL-6 were markedly lower compared with rats treated only with DSS. MAG-EPA per os administration decrease neutrophil infiltration in colon tissues, as depicted by myelohyperoxidase activity. Results also revealed a reduced activation of NF-κB pathways correlated with a decreased expression of COX-2 in colon homogenates derived from MAG-EPA-pretreated and treated rats. Tension measurements performed on colon tissues revealed that contractile responses to methacholine and relaxing effect induced by sodium nitroprusside were largely increased following MAG-EPA treatment. The combined treatment of MAG-EPA and vitamin E displayed an antagonistic effect on anti-inflammatory properties of MAG-EPA in DSS rats. Copyright © 2016 the American Physiological Society.

Computational Toxicology as Implemented by the US EPA ...

EPA Pesticide Factsheets

Computational toxicology is the application of mathematical and computer models to help assess chemical hazards and risks to human health and the environment. Supported by advances in informatics, high-throughput screening (HTS) technologies, and systems biology, the U.S. Environmental Protection Agency EPA is developing robust and flexible computational tools that can be applied to the thousands of chemicals in commerce, and contaminant mixtures found in air, water, and hazardous-waste sites. The Office of Research and Development (ORD) Computational Toxicology Research Program (CTRP) is composed of three main elements. The largest component is the National Center for Computational Toxicology (NCCT), which was established in 2005 to coordinate research on chemical screening and prioritization, informatics, and systems modeling. The second element consists of related activities in the National Health and Environmental Effects Research Laboratory (NHEERL) and the National Exposure Research Laboratory (NERL). The third and final component consists of academic centers working on various aspects of computational toxicology and funded by the U.S. EPA Science to Achieve Results (STAR) program. Together these elements form the key components in the implementation of both the initial strategy, A Framework for a Computational Toxicology Research Program (U.S. EPA, 2003), and the newly released The U.S. Environmental Protection Agency's Strategic Plan for Evaluating the T

EPA Web Training Classes

EPA Pesticide Factsheets

Scheduled webinars can help you better manage EPA web content. Class topics include Drupal basics, creating different types of pages in the WebCMS such as document pages and forms, using Google Analytics, and best practices for metadata and accessibility.

76 FR 38150 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-29

... ID No. EPA-HQ-OEI- 2011-0096, to (1) EPA online using http://www.regulations.gov (our preferred... a public docket for this ICR under Docket ID No. EPA-HQ-OEI-2011-0096, which is available for online..., technology-neutral framework for electronic reporting across all EPA programs; allow EPA programs to offer...

77 FR 22777 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-17

... Docket ID No. EPA-HQ-RCRA-2011-0890, which is available for online viewing at www.regulations.gov , or in person viewing at the Resource Conservation and Recovery Act (RCRA) Docket at the EPA Docket Center (EPA/DC), EPA West, Room 3334, 1301 Constitution Ave. NW., Washington, DC. The EPA/DC Public Reading Room...

77 FR 3262 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-23

... Docket ID No EPA-HQ-RCRA-2011-0624, which is available for online viewing at www.regulations.gov , or in person viewing at the Resource Conservation and Recovery Act (RCRA) Docket in the EPA Docket Center (EPA/DC), EPA West, Room 3334, 1301 Constitution Ave. NW., Washington, DC. The EPA/DC Public Reading Room...

77 FR 66832 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-07

... ICR under docket ID number EPA-HQ-OECA-2012-0505, which is available for public viewing online at http://www.regulations.gov , or in person viewing at the Enforcement and Compliance Docket in the EPA Docket Center (EPA/DC), EPA West, Room 3334, 1301 Constitution Avenue NW., Washington, DC. The EPA Docket Center...

77 FR 22571 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-16

... Docket ID No EPA-HQ-RCRA-2011-0890, which is available for online viewing at www.regulations.gov , or in person viewing at the Resource Conservation and Recovery Act (RCRA) Docket at the EPA Docket Center (EPA/DC), EPA West, Room 3334, 1301 Constitution Ave. NW., Washington, DC. The EPA/DC Public Reading Room...

78 FR 75343 - Pesticide Products; Registration Applications for New Active Ingredients

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-11

...; Registration Applications for New Active Ingredients AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: EPA has received several applications to register pesticide products containing active... products containing active ingredients not included in any currently registered pesticide products...

76 FR 4659 - Science Advisory Board Staff Office; Notification of a Public Teleconference of the Science...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-26

...://yosemite.epa.gov/sab/ sabproduct.nsf/fedrgstr--activities/ FL%20Estuaries%20TSD?OpenDocument'' should read ``http:// yosemite.epa.gov/sab/sabproduct.nsf/fedrgstr--activites/ FL%20Estuaries%20TSD?OpenDocument.'' 2.../sabproduct.nsf/fedrgstr--activities/ FL%20Estuaries%20TSD?OpenDocument'' should read ``http:// yosemite.epa...

Restructuring of Enterococcus faecalis biofilm architecture in response to antibiotic-induced stress

DOE PAGES

Dale, Jennifer L.; Nilson, Jennifer L.; Barnes, Aaron M. T.; ...

2017-06-30

Bacterial biofilms are intrinsically resistant to antimicrobial treatment, which contributes to microbial persistence in clinical infections. Enterococcus faecalis is an opportunistic pathogen that readily forms biofilms and is the most prevalent enterococcal species identified in healthcare-associated infections. Since intrinsic resistance to multiple antibiotics is common for enterococci, and antibiotic resistance is elevated in biofilm populations, it is imperative to understand the mechanisms involved. Previously, we identified two glycosyltransferase genes whose disruption resulted in impaired nascent biofilm formation in the presence of antibiotic concentrations subinhibitory for parent growth and biofilm formation. The glycosyltransferases are involved in synthesis of the cell-wall-associated rhamnopolysaccharidemore » Epa. Here we examined the effect of epa mutations on the temporal development of E. faecalis biofilms, and on the effects of antibiotics on pre-formed biofilms using scanning electron microscopy. We show that ΔepaOX mutant cells arrange into complex multidimensional biofilms independent of antibiotic exposure, while parent cells form biofilms that are monolayers in the absence of antibiotics. Remarkably, upon exposure to antibiotics parent biofilm cells restructure into complex three-dimensional biofilms resembling those of the ΔepaOX mutant without antibiotics. All biofilms exhibiting complex cellular architectures were less structurally stable than monolayer biofilms, with the biofilm cells exhibiting increased detachment. Our results indicate that E. faecalis biofilms restructure in response to cellular stress whether induced by antibiotics in the case of parent cells, or by deficiencies in Epa composition for the ΔepaOX strain. The data demonstrate a link between cellular architecture and antibiotic resistance of E. faecalis biofilms.« less

Restructuring of Enterococcus faecalis biofilm architecture in response to antibiotic-induced stress

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dale, Jennifer L.; Nilson, Jennifer L.; Barnes, Aaron M. T.

Bacterial biofilms are intrinsically resistant to antimicrobial treatment, which contributes to microbial persistence in clinical infections. Enterococcus faecalis is an opportunistic pathogen that readily forms biofilms and is the most prevalent enterococcal species identified in healthcare-associated infections. Since intrinsic resistance to multiple antibiotics is common for enterococci, and antibiotic resistance is elevated in biofilm populations, it is imperative to understand the mechanisms involved. Previously, we identified two glycosyltransferase genes whose disruption resulted in impaired nascent biofilm formation in the presence of antibiotic concentrations subinhibitory for parent growth and biofilm formation. The glycosyltransferases are involved in synthesis of the cell-wall-associated rhamnopolysaccharidemore » Epa. Here we examined the effect of epa mutations on the temporal development of E. faecalis biofilms, and on the effects of antibiotics on pre-formed biofilms using scanning electron microscopy. We show that ΔepaOX mutant cells arrange into complex multidimensional biofilms independent of antibiotic exposure, while parent cells form biofilms that are monolayers in the absence of antibiotics. Remarkably, upon exposure to antibiotics parent biofilm cells restructure into complex three-dimensional biofilms resembling those of the ΔepaOX mutant without antibiotics. All biofilms exhibiting complex cellular architectures were less structurally stable than monolayer biofilms, with the biofilm cells exhibiting increased detachment. Our results indicate that E. faecalis biofilms restructure in response to cellular stress whether induced by antibiotics in the case of parent cells, or by deficiencies in Epa composition for the ΔepaOX strain. The data demonstrate a link between cellular architecture and antibiotic resistance of E. faecalis biofilms.« less

Critical Thoughts About the Core Entrustable Professional Activities in Undergraduate Medical Education.

PubMed

Krupat, Edward

2018-03-01

The Core Entrustable Professional Activities for Entering Residency (Core EPAs) have taken a strong hold on undergraduate medical education (UME). This Perspective questions their value added and considers the utility of the Core EPAs along two separate dimensions: (1) the ways they change the content and focus of the goals of UME; and (2) the extent to which entrustable professional activity (EPA)-based assessment conforms to basic principles of measurement theory as practiced in the social sciences. Concerning content and focus, the author asks whether the 13 Core EPAs frame UME too narrowly, putting competencies into the background and overlooking certain aspirational, but important and measurable, objectives of UME. The author also discusses the unevenness of EPAs in terms of their breadth and their developmental status as core activities. Regarding measurement and assessment, the author raises concerns that the EPA metric introduces layers of inference that may cause distortions and hinder accuracy and rater agreement. In addition, the use of weak anchors and multidimensional scales is also of concern. The author concludes with a proposal for reframing the Core EPAs and Accreditation Council for Graduate Medical Education competencies into broadly defined sets of behaviors, referred to as "Tasks of Medicine," and calls for the development of a systematic and longitudinal research agenda. The author asserts that "slowing down when you should" applies to medical education as well as patient care, and calls for a reevaluation of the Core EPAs before further commitment to them.

75 FR 22786 - Proposed Consent Decree, Clean Air Act Citizen Suit

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-30

..., avoiding the use of special characters and any form of encryption, and may be mailed to the mailing address... comment. Use of the http://www.regulations.gov website to submit comments to EPA electronically is EPA's...

75 FR 16461 - Proposed Settlement Agreement, Clean Air Act Citizen Suit

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-01

... or ASCII file, avoiding the use of special characters and any form of encryption, and may be mailed... comment. Use of the http://www.regulations.gov website to submit comments to EPA electronically is EPA's...

USDA-EPA Collaborative Ammonia Research

EPA Science Inventory

In 2014, a work group was formed between USDA and EPA to facilitate information exchange on ammonia emissions from agriculture, air quality impacts and emission mitigation options and to identify opportunities for collaboration. This document provides background on the work grou...

FY2014 National Clean Diesel Funding Assistance (Diesel Emissions Reduction Act) Programmatic Terms and Conditions

EPA Pesticide Factsheets

EPA will provide substantial involvement in the form of technical assistance, development ofoutputs, and oversight. EPA and the recipient in program content, review of project progress, and quantification and reporting of results.

Biennial reporting system (BRS) data: Generation and management of hazardous waste, 1997 final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1999-05-01

The product contains data compiled by the Biennial Reporting System (BRS) for the ``National Biennial RCRA Hazardous Waste Report (Based on 1997 data).'' The data were collected by states using the ``1997 National Hazardous Waste Report Instructions and Forms'' (EPA Form 8700-13-A/B), or the state's equivalent information source. Data submitted by states prior to December 31, 1997 are included. Data for reports protected by RCRA Confidential Business Information (CBI) claims are not included. These data are preliminary and will be replaced by the final data. The data contain information describing the RCRA wastes generated and/or managed during 1997 by RCRAmore » Treatment, Storage and Disposal Facilities (TSDFs) and RCRA Large Quantity Generators (LQGs). Data are reported by sites meeting the LQG and/or TSDF definitions. Sites are identified by their EPA/RCRA identification number. Response codes match those of the ``1997 Hazardous Waste Report: Instructions and Forms'' (EPA Form 8700-13-A/B).« less

Biennial Reporting System (BRS) data: Generation and management of hazardous waste, 1997 (preliminary)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1999-05-01

The product contains data compiled by the Biennial Reporting System (BRS) for the National Biennial RCRA Hazardous Waste Report (Based on 1997 data). The data were collected by states using the 1997 National Hazardous Waste Report Instructions and Forms (EPA Form 8700-13-A/B), or the state's equivalent information source. Data submitted by states prior to December 31, 1997 are included. Data for reports protected by RCRA Confidential Business Information (CBI) claims are not included. These data are preliminary and will be replaced by the final data. The data contain information describing the RCRA wastes generated and/or managed during 1997 by RCRAmore » Treatment, Storage and Disposal Facilities (TSDFs) and RCRA Large Quantity Generators (LQGs). Data are reported by sites meeting the LQG and/or TSDF definitions. Sites are identified by their EPA/RCRA identification number. Response codes match those of the 1997 Hazardous Waste Report: Instructions and Forms (EPA Form 8700-13-A/B).« less

40 CFR 761.202 - EPA identification numbers.

Code of Federal Regulations, 2010 CFR

2010-07-01

... PROHIBITIONS PCB Waste Disposal Records and Reports § 761.202 EPA identification numbers. (a) General. Any generator, commercial storer, transporter, or disposer of PCB waste who is required to have an EPA identification number under this subpart must notify EPA of his/her PCB waste handling activities, using the...

40 CFR 725.370 - EPA review of the TME application.

Code of Federal Regulations, 2010 CFR

2010-07-01

... unreasonable risk of injury to health and the environment as a result of test marketing. ... Marketing § 725.370 EPA review of the TME application. General procedures for review of all submissions... with test marketing activities after receipt of EPA approval. (c) In approving a TME application, EPA...

EPA eXcats

EPA Pesticide Factsheets

The EPA eXcats is an enterprise-level data tracking application that provides management complaint tracking information for the EPA's Office of Civil Rights (OCR) External Compliance Program. EPA's OCR is responsible for enforcing several federal civil rights laws that together prohibit discrimination on the bases of race, color, national origin (including limited English proficiency), disability, sex and age in programs or activities that receive federal financial assistance from the EPA.

77 FR 12051 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-28

... under Docket ID number EPA-HQ-OARM-2011-0748, which is available for public viewing at www.regulations.gov , or in person viewing at the EPA Docket Center (EPA/DC), EPA West, Room 3334, 1301 Constitution Ave. NW., Washington, DC. The EPA/DC Public Reading Room is open from 8 a.m. to 4:30 p.m., Monday...

Comparative Study of EPA-enriched Phosphatidylcholine and EPA-enriched Phosphatidylserine on Lipid Metabolism in Mice.

PubMed

Ding, Lin; Wang, Dan; Zhou, Miaomiao; Du, Lei; Xu, Jie; Xue, Changhu; Wang, Yuming

2016-07-01

Recent studies have shown that EPA enriched PLs have beneficial effects on lipid metabolism. Our previous study has demonstrated that the anti-obesity and hypolipidemic effects of EPA-PL were superior to DHA-PL. In the present study, we comparatively evaluated the effects of EPA-enriched phosphatidylcholine (EPA-PC) and EPA-enriched phosphatidylserine (EPA-PS) on lipid metabolism in mice. Both 2% dietary EPA-PC and EPA-PS significantly improved serum and hepatic lipid levels in mice. The HDL-c level in mice on EPA-PC diet was significantly higher than the other two groups. The level of DHA in hepatic TG and PL were significantly increased in both EPA-PC and EPA-PS fed groups (98.3 and 117.8%, respectively; p < 0.05). Notably, the proportion of DHA in EPA-PS group was significantly higher than the EPA-PC group. EPA-PC and EPA-PS suppressed hepatic SREBP-1c mediated lipogenesis and activated PPARα mediated fatty acid β-oxidation in the liver. These data are the first to indicate that EPA-PS has beneficial effects on lipid metabolism.

EPA Prevents the Development of Abdominal Aortic Aneurysms through Gpr-120/Ffar-4.

PubMed

Kamata, Ryo; Bumdelger, Batmunkh; Kokubo, Hiroki; Fujii, Masayuki; Yoshimura, Koichi; Ishida, Takafumi; Ishida, Mari; Yoshizumi, Masao

2016-01-01

Abdominal aortic aneurysms (AAAs), which commonly occur among elderly individuals, are accompanied by a risk of rupture with a high mortality rate. Although eicosapentaenoic acid (EPA) has been reported to prevent AAA formation, the mechanism by which EPA works on vascular smooth muscle cells is unknown. This study aimed to investigate the mechanism by which orally-administered EPA prevents the formation of severe AAAs that develop in Osteoprotegerin (Opg) knockout (KO) mice. In the CaCl2-induced AAA model, EPA attenuated the enhanced progression of AAAs in Opg-KO mice, including the increase in aortic diameter with destruction of elastic fibers in the media. Immunohistochemical analyses showed that EPA reduced the phosphorylation of transforming growth factor beta-activated kinase-1/Map3k7 (Tak-1) and c-Jun NH2-terminal kinase (JNK), as well as the expression of Matrix metalloproteinase-9 (Mmp-9) in the media of the aorta. In smooth muscle cell cultures, rh-TRAIL-induced activation of the Tak-1-JNK pathway and increase in Mmp-9 expression were inhibited by EPA. Moreover, GW9508, a specific ligand for G-protein coupled receptor (Gpr)-120/Free fatty acid receptor (Ffar)-4, mimicked the effects of EPA. The effects of EPA were abrogated by knockdown of the Gpr-120/Ffar-4 receptor gene. Our data demonstrate that the Trail-Tak-1-JNK-Mmp-9 pathway is responsible for the enhancement of AAAs in Opg-KO mice, and that EPA inhibits the Tak-1-JNK pathway by activating Gpr-120/Ffar-4, which results in the attenuation of AAA development.

EPA Prevents the Development of Abdominal Aortic Aneurysms through Gpr-120/Ffar-4

PubMed Central

Kamata, Ryo; Bumdelger, Batmunkh; Kokubo, Hiroki; Fujii, Masayuki; Yoshimura, Koichi; Ishida, Takafumi; Ishida, Mari; Yoshizumi, Masao

2016-01-01

Abdominal aortic aneurysms (AAAs), which commonly occur among elderly individuals, are accompanied by a risk of rupture with a high mortality rate. Although eicosapentaenoic acid (EPA) has been reported to prevent AAA formation, the mechanism by which EPA works on vascular smooth muscle cells is unknown. This study aimed to investigate the mechanism by which orally-administered EPA prevents the formation of severe AAAs that develop in Osteoprotegerin (Opg) knockout (KO) mice. In the CaCl2-induced AAA model, EPA attenuated the enhanced progression of AAAs in Opg-KO mice, including the increase in aortic diameter with destruction of elastic fibers in the media. Immunohistochemical analyses showed that EPA reduced the phosphorylation of transforming growth factor beta-activated kinase-1/Map3k7 (Tak-1) and c-Jun NH2-terminal kinase (JNK), as well as the expression of Matrix metalloproteinase-9 (Mmp-9) in the media of the aorta. In smooth muscle cell cultures, rh-TRAIL-induced activation of the Tak-1-JNK pathway and increase in Mmp-9 expression were inhibited by EPA. Moreover, GW9508, a specific ligand for G-protein coupled receptor (Gpr)-120/Free fatty acid receptor (Ffar)-4, mimicked the effects of EPA. The effects of EPA were abrogated by knockdown of the Gpr-120/Ffar-4 receptor gene. Our data demonstrate that the Trail-Tak-1-JNK-Mmp-9 pathway is responsible for the enhancement of AAAs in Opg-KO mice, and that EPA inhibits the Tak-1-JNK pathway by activating Gpr-120/Ffar-4, which results in the attenuation of AAA development. PMID:27764222

77 FR 65683 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-30

... Activities; Submission to OMB for Review and Approval; Comment Request; EPA's Design for the Environment (DfE... Budget (OMB) for review and approval: EPA's Design for the Environment (DfE) Partner of the Year Awards... . Title: EPA's Design for the Environment (DfE) Partner of the Year Awards Program. ICR Status: This is a...

78 FR 10167 - Pesticide Products; Registration Applications for a New Active Ingredient

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-13

...; Registration Applications for a New Active Ingredient AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: EPA has received applications to register pesticide products containing an active... applications to register pesticide products containing an active ingredient not included in any currently...

FY2014 National Clean Diesel Funding Assistance (Diesel Emissions Reduction Act) Programmatic Terms and Conditions

EPA Pesticide Factsheets

Substantial federal involvement will take the form of monitoring the project by EPA, participation and collaboration between EPA and the recipient in program content, review of project progress, and quantification and reporting ofresults.

77 FR 61117 - Significant New Use Rules on Certain Chemical Substances

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-05

...EPA is promulgating significant new use rules (SNURs) under the Toxic Substances Control Act (TSCA) for 78 chemical substances which were the subject of premanufacture notices (PMNs). Seven of these chemical substances are subject to TSCA section 5(e) consent orders issued by EPA. This action requires persons who intend to manufacture, import, or process any of these 78 chemical substances for an activity that is designated as a significant new use by this rule to notify EPA at least 90 days before commencing that activity. The required notification will provide EPA with the opportunity to evaluate the intended use and, if necessary, to prohibit or limit that activity before it occurs.

Metabolic Effects of n-3 PUFA as Phospholipids Are Superior to Triglycerides in Mice Fed a High-Fat Diet: Possible Role of Endocannabinoids

PubMed Central

Rossmeisl, Martin; Macek Jilkova, Zuzana; Kuda, Ondrej; Jelenik, Tomas; Medrikova, Dasa; Stankova, Barbora; Kristinsson, Björn; Haraldsson, Gudmundur G.; Svensen, Harald; Stoknes, Iren; Sjövall, Peter; Magnusson, Ylva; Balvers, Michiel G. J.; Verhoeckx, Kitty C. M.; Tvrzicka, Eva; Bryhn, Morten; Kopecky, Jan

2012-01-01

Background n-3 polyunsaturated fatty acids, namely docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), reduce the risk of cardiovascular disease and can ameliorate many of obesity-associated disorders. We hypothesised that the latter effect will be more pronounced when DHA/EPA is supplemented as phospholipids rather than as triglycerides. Methodology/Principal Findings In a ‘prevention study’, C57BL/6J mice were fed for 9 weeks on either a corn oil-based high-fat obesogenic diet (cHF; lipids ∼35% wt/wt), or cHF-based diets in which corn oil was partially replaced by DHA/EPA, admixed either as phospholipids or triglycerides from marine fish. The reversal of obesity was studied in mice subjected to the preceding cHF-feeding for 4 months. DHA/EPA administered as phospholipids prevented glucose intolerance and tended to reduce obesity better than triglycerides. Lipemia and hepatosteatosis were suppressed more in response to dietary phospholipids, in correlation with better bioavailability of DHA and EPA, and a higher DHA accumulation in the liver, white adipose tissue (WAT), and muscle phospholipids. In dietary obese mice, both DHA/EPA concentrates prevented a further weight gain, reduced plasma lipid levels to a similar extent, and tended to improve glucose tolerance. Importantly, only the phospholipid form reduced plasma insulin and adipocyte hypertrophy, while being more effective in reducing hepatic steatosis and low-grade inflammation of WAT. These beneficial effects were correlated with changes of endocannabinoid metabolome in WAT, where phospholipids reduced 2-arachidonoylglycerol, and were more effective in increasing anti-inflammatory lipids such as N-docosahexaenoylethanolamine. Conclusions/Significance Compared with triglycerides, dietary DHA/EPA administered as phospholipids are superior in preserving a healthy metabolic profile under obesogenic conditions, possibly reflecting better bioavalability and improved modulation of the endocannabinoid system activity in WAT. PMID:22701720

40 CFR 725.270 - EPA review of the TERA.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 30 2010-07-01 2010-07-01 false EPA review of the TERA. 725.270... Development Activities § 725.270 EPA review of the TERA. General procedures for review of all submissions... to EPA review of applications submitted under this subpart: (a) Length of the review period. (1) The...

75 FR 71430 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-23

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-RCRA-2010-0512, FRL- 9230-5] Agency Information Collection...), EPA ICR Number 1442.21, OMB Control Number 2050-0085 AGENCY: Environmental Protection Agency. ACTION.... ADDRESSES: Submit your comments, referencing Docket ID No. EPA-HQ-RCRA- 2010-0512, to (1) EPA, either online...

75 FR 3723 - Agency Information Collection Activities; Proposed Collections; Comment Requests; Information...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-22

...; Information Requirements for Importation of Nonconforming Vehicles; EPA ICR No. 0010.12, OMB Control No. 2060... Certification Program, EPA ICR No. 116.09, OMB Control No. 2060-0060; and Motor Vehicle and Engine Compliance Program Fees, EPA ICR 2080.04, OMB Control No. 2060-0545 AGENCY: Environmental Protection Agency (EPA...

AVOIDING PITFALLS IN THE DETERMINATION OF HALOCARBOXYLIC ACIDS: THE PHOTOCHEMISTRY OF METHYLATION

EPA Science Inventory

Haloethanoic (haloacetic) acids are formed during chlorination of drinking water and are regulated by the Environmental Protection Agency (EPA). These compounds are normally quantified by gas chromatography with electron capture detection (GC-ECD) ad the methyl esters. EPA Meth...

Eicosapentaenoic acid (EPA) induced apoptosis in HepG2 cells through ROS–Ca{sup 2+}–JNK mitochondrial pathways

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Yuanyuan; Han, Lirong; Qi, Wentao

Highlights: • EPA evoked ROS formation, [Ca{sup 2+}]{sub c} accumulation, the opening of MPTP and the phosphorylation of JNK. • EPA-induced [Ca{sup 2+}]{sub c} elevation was depended on production of ROS. • EPA-induced ROS generation, [Ca{sup 2+}]{sub c} increase, and JNK activated caused MPTP opening. • The apoptosis induced by EPA was related to release of cytochrome C through the MPTP. • EPA induced HepG2 cells apoptosis through ROS–Ca{sup 2+}–JNK mitochondrial pathways. - Abstract: Eicosapentaenoic acid (EPA), a well-known dietary n−3 PUFAS, has been considered to inhibit proliferation of tumor cells. However, the molecular mechanism related to EPA-induced liver cancermore » cells apoptosis has not been reported. In this study, we investigated the effect of EPA on HepG2 cells proliferation and apoptosis mechanism through mitochondrial pathways. EPA inhibited proliferation of HepG2 cells in a dose-dependent manner and had no significant effect on the cell viability of humor normal liver L-02 cells. It was found that EPA initially evoked ROS formation, leading to [Ca{sup 2+}]{sub c} accumulation and the mitochondrial permeability transition pore (MPTP) opening; EPA-induced HepG2 cells apoptosis was inhibited by N-acetylcysteine (NAC, an inhibitor of ROS), 1,2-bis (2-aminophenoxy) ethane-N,N,N′,N′-tetraacetic acid (BAPTA-AM, a chelator of calcium) and CsA (inhibitor of MPTP). The relationship between ROS production, the increase of cytoplasmic Ca and MPTP opening was detected. It seems that ROS may act as an upstream regulator of EPA-induced [Ca{sup 2+}]{sub c} generation, moreover, generation of ROS, overload of mitochondrial [Ca{sup 2+}]{sub c}, and JNK activated cause the opening of MPTP. Western blotting results showed that EPA elevated the phosphorylation status of JNK, processes associated with the ROS generation. Simultaneously, the apoptosis induced by EPA was related to release of cytochrome C from mitochondria to cytoplasm through the MPTP and activation of caspase-9 and caspase-3. These results suggest that EPA induces apoptosis through ROS–Ca{sup 2+}–JNK mitochondrial pathways.« less

Comparative analysis of effects of dietary arachidonic acid and EPA on growth, tissue fatty acid composition, antioxidant response and lipid metabolism in juvenile grass carp, Ctenopharyngodon idellus.

PubMed

Tian, Jing-Jing; Lei, Cai-Xia; Ji, Hong; Kaneko, Gen; Zhou, Ji-Shu; Yu, Hai-Bo; Li, Yang; Yu, Er-Meng; Xie, Jun

2017-09-01

Four isonitrogenous and isoenergetic purified diets containing free arachidonic acid (ARA) or EPA (control group), 0·30 % ARA, 0·30 % EPA and 0·30 % ARA+EPA (equivalent) were designed to feed juvenile grass carp (10·21 (sd 0·10) g) for 10 weeks. Only the EPA group presented better growth performance compared with the control group (P<0·05). Dietary ARA and EPA were incorporated into polar lipids more than non-polar lipids in hepatopancreas but not intraperitoneal fat (IPF) tissue. Fish fed ARA and EPA showed an increase of serum superoxide dismutase and catalase activities, and decrease of glutathione peroxidase activity and malondialdehyde contents (P<0·05). The hepatopancreatic TAG levels decreased both in ARA and EPA groups (P<0·05), accompanied by the decrease of lipoprotein lipase (LPL) activity in the ARA group (P<0·05). Fatty acid synthase (FAS), diacylglycerol O-acyltransferase and apoE gene expression in the hepatopancreas decreased in fish fed ARA and EPA, but only the ARA group exhibited increased mRNA level of adipose TAG lipase (ATGL) (P<0·05). Decreased IPF index and adipocyte sizes were found in the ARA group (P<0·05). Meanwhile, the ARA group showed decreased expression levels of adipogenic genes CCAAT enhancer-binding protein α, LPL and FAS, and increased levels of the lipid catabolic genes PPAR α, ATGL, hormone-sensitive lipase and carnitine palmitoyltransferase 1 (CPT-1) in IPF, whereas the EPA group only increased PPAR α and CPT-1 mRNA expression and showed less levels than the ARA group. Overall, dietary EPA is beneficial to the growth performance, whereas ARA is more potent in inducing lipolysis and inhibiting adipogenesis, especially in IPF. Meanwhile, dietary ARA and EPA showed the similar preference in esterification and the improvement in antioxidant response.

Omega-3 fatty acids, EPA and DHA induce apoptosis and enhance drug sensitivity in multiple myeloma cells but not in normal peripheral mononuclear cells.

PubMed

Abdi, J; Garssen, J; Faber, J; Redegeld, F A

2014-12-01

The n-3 polyunsaturated fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been shown to enhance the effect of chemotherapeutic drugs in clinical studies in cancer patients and to induce apoptotic tumor cell death in vitro. Until now, EPA and DHA have never been investigated in multiple myeloma (MM). Human myeloma cells (L363, OPM-1, OPM-2 and U266) and normal peripheral blood mononuclear cells were exposed to EPA and DHA, and effects on mitochondrial function and apoptosis, caspase-3 activation, gene expression and drug toxicity were measured. Exposure to EPA and DHA induced apoptosis and increased sensitivity to bortezomib in MM cells. Importantly, they did not affect viability of normal human peripheral mononuclear cells. Messenger RNA expression arrays showed that EPA and DHA modulated genes involved in multiple signaling pathways including nuclear factor (NF) κB, Notch, Hedgehog, oxidative stress and Wnt. EPA and DHA inhibited NFκB activity and induced apoptosis through mitochondrial perturbation and caspase-3 activation. Our study suggests that EPA and DHA induce selective cytotoxic effects in MM and increase sensitivity to bortezomib and calls for further exploration into a potential application of these n-3 polyunsaturated fatty acids in the therapy of MM. Copyright © 2014 Elsevier Inc. All rights reserved.

78 FR 70043 - Pesticide Product Registration; Receipt of an Application for a New Active Ingredient

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-22

...; Receipt of an Application for a New Active Ingredient AGENCY: Environmental Protection Agency (EPA... active ingredient not included in any previously registered pesticide product. Pursuant to the Federal... Application EPA has received an application to register a pesticide product containing an active ingredient...

Inhibitory effects of omega-3 fatty acids on injury-induced epidermal growth factor receptor transactivation contribute to delayed wound healing

PubMed Central

Turk, Harmony F.; Monk, Jennifer M.; Fan, Yang-Yi; Callaway, Evelyn S.; Weeks, Brad

2013-01-01

Epidermal growth factor receptor (EGFR)-mediated signaling is required for optimal intestinal wound healing. Since n-3 polyunsaturated fatty acids (PUFA), specifically docosahexaenoic acid (DHA), alter EGFR signaling and suppress downstream activation of key signaling pathways, we hypothesized that DHA would be detrimental to the process of intestinal wound healing. Using a mouse immortalized colonocyte model, DHA uniquely reduced EGFR ligand-induced receptor activation, whereas DHA and its metabolic precursor eicosapentaenoic acid (EPA) reduced wound-induced EGFR transactivation compared with control (no fatty acid or linoleic acid). Under wounding conditions, the suppression of EGFR activation was associated with a reduction in downstream activation of cytoskeletal remodeling proteins (PLCγ1, Rac1, and Cdc42). Subsequently, DHA and EPA reduced cell migration in response to wounding. Mice were fed a corn oil-, DHA-, or EPA-enriched diet prior to intestinal wounding (2.5% dextran sodium sulfate for 5 days followed by termination after 0, 3, or 6 days of recovery). Mortality was increased in EPA-fed mice and colonic histological injury scores were increased in EPA- and DHA-fed mice compared with corn oil-fed (control) mice. Although kinetics of colonic EGFR activation and downstream signaling (PLCγ1, Rac1, and Cdc42) were delayed by both n-3 PUFA, colonic repair was increased in EPA- relative to DHA-fed mice. These results indicate that, during the early response to intestinal wounding, DHA and EPA uniquely delay the activation of key wound-healing processes in the colon. This effect is mediated, at least in part, via suppression of EGFR-mediated signaling and downstream cytoskeletal remodeling. PMID:23426968

EPA Regulation of Bed Bug Pesticides

EPA Pesticide Factsheets

All pesticides must be registered by EPA before being sold and used in the U.S., other than those that rely on a limited set of active ingredients (so-called minimum risk pesticides). EPA reviews for safety and effectiveness.

Report: EPA Should Timely Deobligate Unneeded Contract, Purchase and Miscellaneous Funds

EPA Pesticide Factsheets

Report #16-P-0135, April 11, 2016. When the EPA does not deobligate unliquidated obligations timely, the funds cannot be used for other EPA environmental activities that would benefit human health and the environment.

PM: RESEARCH METHODS FOR PM TOXIC COMPOUNDS - PARTICLE METHODS EVALUATION AND DEVELOPMENT

EPA Science Inventory

The Federal Reference Method (FRM) for Particulate Matter (PM) developed by EPA's National Exposure Research Laboratory (NERL) forms the backbone of the EPA's national monitoring strategy. It is the measurement that defines attainment of the National Ambient Air Quality Standard...

Updates on the EPA Study of Lead Scavengers (EDB and DCA)

EPA Science Inventory

In response to continued concerns about the concentrations of 1,2-dibromoethane (EDB) in ground water from spills of leaded gasoline, OUST formed a Lead Scavengers Team with assistance from ASTSWMO. ASTSWMO and EPA Regions solicited participation from state agencies. Analysis w...

77 FR 38624 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

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2010-12-07

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78 FR 37804 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

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Omega-3 supplementation improves cognition and modifies brain activation in young adults.

PubMed

Bauer, Isabelle; Hughes, Matthew; Rowsell, Renee; Cockerell, Robyn; Pipingas, Andrew; Crewther, Sheila; Crewther, David

2014-03-01

The current study aimed to investigate the effects of eicosapentaenoic acid (EPA)-rich and docosahexaenoic acid (DHA)-rich supplementations on cognitive performance and functional brain activation. A double-blind, counterbalanced, crossover design, with a 30-day washout period between two supplementation periods (EPA-rich and DHA-rich) was employed. Functional magnetic resonance imaging scans were obtained during performance of Stroop and Spatial Working Memory tasks prior to supplementation and after each 30-day supplementation period. Both supplementations resulted in reduced ratio of arachidonic acid to EPA levels. Following the EPA-rich supplementation, there was a reduction in functional activation in the left anterior cingulate cortex and an increase in activation in the right precentral gyrus coupled with a reduction in reaction times on the colour-word Stroop task. By contrast, the DHA-rich supplementation led to a significant increase in functional activation in the right precentral gyrus during the Stroop and Spatial Working Memory tasks, but there was no change in behavioural performance. By extending the theory of neural efficiency to the within-subject neurocognitive effects of supplementation, we concluded that following the EPA-rich supplementation, participants' brains worked 'less hard' and achieved a better cognitive performance than prior to supplementation. Conversely, the increase in functional activation and lack of improvement in time or accuracy of cognitive performance following DHA-rich supplementation may indicate that DHA-rich supplementation is less effective than EPA-rich supplementation in enhancing neurocognitive functioning after a 30-day supplementation period in the same group of individuals.

1990 Environmental monitoring report, Tonopah Test Range, Tonopah, Nevada

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hwang, A.; Phelan, J.; Wolff, T.

1991-05-01

There is no routine radioactive emission from Sandia National Laboratories, Tonopah Test Range (SNL, TTR). However, based on the types of test activities such as air drops, gun firings, ground- launched rockets, air-launched rockets, and other explosive tests, possibilities exist that small amounts of depleted uranium (DU) (as part of weapon components) may be released to the air or to the ground because of unusual circumstances (failures) during testing. Four major monitoring programs were used in 1990 to assess radiological impact on the public. The EPA Air Surveillance Network (ASN) found that the only gamma ({gamma}) emitting radionuclide on themore » prefilters was beryllium-7 ({sup 7}Be), a naturally-occurring spallation product formed by the interaction of cosmic radiation with atmospheric oxygen and nitrogen. The weighted average results were consistent with the area background concentrations. The EPA Thermoluminescent Dosimetry (TLD) Network and Pressurized Ion Chamber (PIC) reported normal results. In the EPA Long-Term Hydrological Monitoring Program (LTHMP), analytical results for tritium ({sup 3}H) in well water were reported and were well below DOE-derived concentration guides (DCGs). In the Reynolds Electrical and Engineering Company (REECo) Drinking Water Sampling Program, analytical results for {sup 3}H, gross alpha ({alpha}), beta ({beta}), and {gamma} scan, strontium-90 ({sup 90}Sr) and plutonium-239 ({sup 239}Pu) were within the EPA's primary drinking water standards. 29 refs., 5 figs., 15 tabs.« less

Biological activity of the azlactone derivative EPA-35 against Trypanosoma cruzi.

PubMed

de Azeredo, Camila Maria Oliveira; Ávila, Eloah Pereira; Pinheiro, Danielle Lobo Justo; Amarante, Giovanni Wilson; Soares, Maurilio José

2017-02-01

Chagas disease, caused by Trypanosoma cruzi, affects six to seven million people worldwide. Treatment is based on benznidazole, producing several side effects and debatable efficacy, highlighting the need for new alternative drugs. We investigated the activity of four C-4 functionalized azlactone derivatives (EPA-27, EPA-35, EPA-63 and EPA-91) as potential T. cruzi inhibitors. Screening with epimastigotes indicated EPA-35 as the best compound (IC50/24 h: 33 μM). This compound was 14.1 times more potent against intracellular amastigotes (IC50/24 h: 2.34 μM). Treatment of infected Vero cells for 72 h (up to 30 μM EPA-35) resulted in a dose-dependent decrease in number of trypomastigotes and amastigotes released in the supernatant, but the amastigote/trypomastigote ratio remained constant, indicating that amastigote growth was disturbed, but cell differentiation was unaffected. Analysis of treated epimastigotes by flow cytometry indicated that the plasma membrane remained intact, but there was a significant decrease in mitochondrial membrane potential. The pattern of cell distribution in the cell cycle stages (G1, G2, M) was unaltered in treated epimastigotes, indicating a trypanocidal rather than a trypanostatic activity. Scanning electron microscopy and flow cytometry showed epimastigotes with a round shape and decrease in cell size. Taken together, our data indicate that the EPA-35 is effective against T. cruzi. Synthetic transformation of EPA-35 into other derivatives may provide promising compounds for further evaluation against this parasite. © FEMS 2017. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

R6 FIFRA e-Notice of Arrival

EPA Pesticide Factsheets

This database processes approximately 3,000 Notice of Arrival (NOA) reporting forms from importers and exporters of pesticide products. This is an electronic version of the EPA Form 3540-1. The external user fills out the NOA and submits it electronically. The form is then processed by the Pesticides section and either approved or disapproved. The system then generates an Adobe PDF version of the EPA Form 3540-1 with signature or disapproval and emailed to the external user. The e-filing system eliminates the need for the Region to invest in paper, copying, storage and mailing expenses, while at the same time allowing the regulated community to conduct its business with us in a more expeditious manner.

77 FR 3766 - Agency Information Collection Activities; Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-25

... Constitution Ave. NW., Washington, DC. Attention: Docket ID Number EPA-HQ-OPPT-2011-0777. The DCO is open from..., and submit this information to EPA. EPA uses this information to construct a complete picture of the...

Forms Management Policy

EPA Pesticide Factsheets

To establish EPA’s Forms Management Program; to describe the requisite roles, responsibilities, and procedures necessary for the successful management of EPA forms; and to more clearly fulfill EPA’s obligations in this regard.

An entrustable professional activity (EPA) for handoffs as a model for EPA assessment development.

PubMed

Aylward, Michael; Nixon, James; Gladding, Sophia

2014-10-01

Medical education is moving toward assessment of educational outcomes rather than educational processes. The American Board of Internal Medicine and American Board of Pediatrics milestones and the concept of entrustable professional activities (EPA)--skills essential to the practice of medicine that educators progressively entrust learners to perform--provide new approaches to assessing outcomes. Although some defined EPAs exist for internal medicine and pediatrics, the continued development and implementation of EPAs remains challenging. As residency programs are expected to begin reporting milestone-based performance, however, they will need examples of how to overcome these challenges. The authors describe a model for the development and implementation of an EPA using the resident handoff as an example. The model includes nine steps: selecting the EPA, determining where skills are practiced and assessed, addressing barriers to assessment, determining components of the EPA, determining needed assessment tools, developing new assessments if needed, determining criteria for advancement through entrustment levels, mapping milestones to the EPA, and faculty development. Following implementation, 78% of interns at the University of Minnesota Medical School were observed giving handoffs and provided feedback. The authors suggest that this model of EPA development--which includes engaging stakeholders, an iterative process to describing the behavioral characteristics of each domain at each level of entrustment, and the development of specific assessment tools that support both formative feedback and summative decisions about entrustment--can serve as a model for EPA development for other clinical skills and specialty areas.

78 FR 37806 - Information Collection Request Submitted to OMB for Review and Approval; Comment Request; EPA's...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-24

... profanity, threats, information claimed to be Confidential Business Information (CBI) or other information... strategic planning efforts, EPA encourages programs to develop meaningful performance measures, set...), Licensed Certification Providers (6100-20), Licensed Certifying Body (6100-13) Annual Reporting Form...

Decreased eicosapentaenoic acid levels in acne vulgaris reveals the presence of a proinflammatory state.

PubMed

Aslan, İbrahim; Özcan, Filiz; Karaarslan, Taner; Kıraç, Ebru; Aslan, Mutay

2017-01-01

This study aimed to determine circulating levels of polyunsaturated fatty acids (PUFAs), secretory phospholipase A2 (sPLA2), lipoprotein lipase (LPL) and measure circulating protein levels of angiopoietin-like protein 3 (ANGPTL3), ANGPTL4, cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2) in patients with acne vulgaris. Serum from 21 control subjects and 31 acne vulgaris patients were evaluated for levels of arachidonic acid (AA, C20:4n- 6), dihomo-gamma-linolenic acid (DGLA, C20:3n-6), eicosapentaenoic acid (EPA, C20:5n-3) and docosahexaenoic acid (DHA, C22:6n-3). PUFA levels were determined by an optimized multiple reaction monitoring (MRM) method using ultra fast-liquid chromatography (UFLC) coupled with tandem mass spectrometry (MS/MS). Lipid profile, routine biochemical and hormone parameters were assayed by standard kit methods Serum EPA levels were significantly decreased while AA/EPA and DGLA/EPA ratio were significantly increased in acne vulgaris patients compared to controls. Serum levels of AA, DGLA and DHA showed no significant difference while activity of sPLA2 and LPL were significantly increased in acne vulgaris compared to controls. Results of this study reveal the presence of a proinflammatory state in acne vulgaris as shown by significantly decreased serum EPA levels and increased activity of sPLA2, AA/EPA and DGLA/EPA ratio. Increased LPL activity in the serum of acne vulgaris patients can be protective through its anti-dyslipidemic actions. This is the first study reporting altered EPA levels and increased sPLA2 activity in acne vulgaris and supports the use of omega-3 fatty acids as adjuvant treatment for acne patients. Copyright © 2016 Elsevier Inc. All rights reserved.

77 FR 35331 - Trichoderma reesei; Proposed Significant New Use Rule

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-13

... biological activities and have antifungal, antibacterial, sometimes antiviral, antiparasitic, and neurotoxic... (T. reesei). This microorganism was the subject of a Microbial Commercial Activity Notice (MCAN). EPA... activity before it occurs, if EPA determines it may be hazardous. DATES: Comments must be received on or...

77 FR 72342 - Notice of Receipt of Pesticide Products; Registration Applications

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2012-12-05

...: EPA has received applications to register pesticide products containing an active ingredient not... applications to register pesticide products containing an active ingredient not included in any currently... containing an active ingredient not included in any currently registered products: 1. EPA File Symbol: 43808...

PHYSICAL ACTIVITY INDEX FOR CHILDREN: A COMPARISON OF LITERATURE VALUES AND EPA'S CHAD

EPA Science Inventory

The physical activity index (PAI) is a measure of an individual's energy expenditure level (and thus oxygen consumption) calculated as a time-weighted average of metabolic equivalents (METS) over the individual's activities. Many exposure models rely upon EPA's CHAD data base to ...

76 FR 58493 - Agency Information Collection Activities; Proposed Collection; Comment Request; Requirements for...

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2011-09-21

..., which means EPA will not know your identity or contact information unless you provide it in the body of....regulations.gov , or in person viewing at the RCRA Docket in the EPA Docket Center (EPA/DC), EPA West, Room... Agency may not conduct or sponsor, and a person is not required to respond to, a collection of...

77 FR 74000 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-12

... public viewing online at http://www.regulations.gov , or in person viewing at the Enforcement and Compliance Docket in the EPA Docket Center (EPA/ DC), EPA West, Room 3334, 1301 Constitution Avenue NW., Washington, DC. The EPA Docket Center Public Reading Room is open from 8:30 a.m. to 4:30 p.m., Monday through...

77 FR 37671 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-22

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78 FR 77672 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

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2013-12-24

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78 FR 29368 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

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2013-05-20

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77 FR 39704 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-05

...-0263, which is available for public viewing online at http://www.regulations.gov , or in person viewing at the Enforcement and Compliance Docket in the EPA Docket Center (EPA/DC), EPA West, Room 3334, 1301 Constitution Avenue NW., Washington, DC. The EPA Docket Center Public Reading Room is open from 8:30 a.m. to 4...

Long-chain n-3 PUFA supplementation decreases physical activity during class time in iron-deficient South African school children.

PubMed

Smuts, Cornelius M; Greeff, Jani; Kvalsvig, Jane; Zimmermann, Michael B; Baumgartner, Jeannine

2015-01-28

Both Fe deficiency and poor n-3 fatty acid status have been associated with behavioural changes in children. In the present study, we investigated the effects of Fe and DHA+EPA supplementation, alone or in combination, on physical activity during school days and on teacher-rated behaviour in healthy Fe-deficient school children. In a 2 × 2 factorial design, children (n 98, 6-11 years) were randomly assigned to receive (1) Fe (50 mg) plus DHA (420 mg)+EPA (80 mg), (2) Fe plus placebo, (3) placebo plus DHA+EPA or (4) placebo plus placebo as oral supplements (4 d/week) for 8.5 months. Physical activity was measured during four school days at baseline and endpoint using accelerometers, and data were stratified into morning class time (08.00-10.29 hours), break time (10.30-11.00 hours) and after-break class time (11.01-12.00 hours) for analysis. Classroom behaviour was assessed at endpoint using Conners' Teacher Rating Scales. DHA+EPA supplementation decreased physical activity counts during morning class time, increased sedentary physical activity, and decreased light- and moderate-intensity physical activities. Consistently, DHA+EPA supplementation increased sedentary physical activity and decreased light-intensity physical activity during after-break class time. Even though there were no treatment effects found on teacher-rated behaviour, lower physical activity during morning class time was associated with lower levels of teacher-rated hyperactivity and oppositional behaviour at endpoint. Despite a positive association between Fe status and physical activity during break time at baseline, Fe supplementation did not affect physical activity during break time and class time. Our findings suggest that DHA+EPA supplementation may decrease physical activity levels during class time, and further indicate that accelerometry might be a useful tool to assess classroom behaviour in healthy children.

40 CFR 6.401 - Applicability.

Code of Federal Regulations, 2010 CFR

2010-07-01

... ENVIRONMENTAL POLICY ACT AND ASSESSING THE ENVIRONMENTAL EFFECTS ABROAD OF EPA ACTIONS Assessing the Environmental Effects Abroad of EPA Actions § 6.401 Applicability. (a) Administrative actions requiring... addressed in the facility plan would have environmental effects abroad. (5) Other EPA activities as...

75 FR 5581 - Agency Information Collection Activities; Proposed Collection; Comment Request; Registration of...

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2010-02-03

... Manufacturers; EPA ICR No. 0309.13, OMB Control No. 2060-0150 AGENCY: Environmental Protection Agency (EPA... numbers: EPA ICR No. 0309.13, OMB Control No. 2060-0150. ICR status: This ICR is currently scheduled to...

77 FR 42304 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

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2012-07-18

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EPA SCIENCE FORUM - EPA'S TOXICOGENOMICS PARTNERSHIPS ACROSS GOVERNMENT, ACADEMIA AND INDUSTRY

EPA Science Inventory

Over the past decade genomics, proteomics and metabonomics technologies have transformed the science of toxicology, and concurrent advances in computing and informatics have provided management and analysis solutions for this onslaught of toxicogenomic data. EPA has been actively...

EPA Presentation Regarding the Advanced Light-Duty Powertrain and Hybrid Analysis (ALPHA) Tool

EPA Pesticide Factsheets

This page contains a selection of the presentations that EPA has publicly presented about our work on the Midterm Evaluation (MTE). It highlights EPA's benchmarking and modeling activities relating to light duty greenhouse gas (GHG) emissions.

EPA Perspectives on Nanoinformatics for Prioritization and Toxicity Testing

EPA Science Inventory

The U.S. Environmental Protection Agency’s (EPA) Office of Research and Development is investigating the environmental health and safety implications of engineered nanomaterials. Research activities as outlined in ORD’s Nanomaterial Strategy (http://www.epa.gov/nanoscience/files/...

Potential Application of Eicosapentaenoic Acid Monoacylglyceride in the Management of Colorectal Cancer

PubMed Central

Morin, Caroline; Rodríguez, Enrique; Blier, Pierre U.; Fortin, Samuel

2017-01-01

Background: There is increasing evidence that marine omega-3 oils are involved in the reduction of cancer risk and progression. However, the anticancer effect of omega-3 monoglyceride on colorectal cancer has yet to be assessed. The goal of this study was to evaluate the anti-cancer effects of eicosapentaenoic acid monoglyceride (MAG-EPA) in HCT116 colorectal carcinoma cells. Methods: The effect of MAG-EPA was evaluated in vitro on HCT116 cells and in vivo on mouse model of HCT116 xenograft. Results: Our data reveal that MAG-EPA decreased cell proliferation and induced apoptosis in HCT116 cells. In a xenograft mouse model, daily per os administration of MAG-EPA reduced tumor growth. Furthermore, MAG-EPA treatments decreased EGFR, VEGFR, and AKT activation pathways and reduced VEGF and HIF1α expression levels in tumors. Conclusion: MAG-EPA may promote apoptosis and inhibit growth of tumors by suppressing EGFR and VEGFR activation pathways. Altogether, these data provide new evidence regarding the mode of action of MAG-EPA in colorectal cancer cells. PMID:28869531

75 FR 38068 - Public Meeting With Interested Stakeholders for National Pollutant Discharge Elimination System...

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2010-07-01

... states to report to EPA. Expected benefits include lower processing costs for facilities and states... efficiencies should provide significant benefits, including reduced costs of processing paper forms, improved... biosolids) could be adapted into electronic reporting, costs and benefits to the states, permittees, EPA and...

EPA Project Updates: DSSTox and ToxCast Generating New Data and Data Linkages for Use in Predictive Modeling

EPA Science Inventory

EPAs National Center for Computational Toxicology is building capabilities to support a new paradigm for toxicity screening and prediction. The DSSTox project is improving public access to quality structure-annotated chemical toxicity information in less summarized forms than tr...

78 FR 46940 - Hazardous and Solid Waste Management System: Identification and Listing of Special Wastes...

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2013-08-02

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Data Report On Ecosystem Monitoring For The Ashtabula River Environmental Dredging Project

EPA Science Inventory

A partnership was formed in 2006 between the National Risk Management Research Laboratory (NRMRL) and the National Exposure Research Laboratory (NERL) of the U.S. Environmental Protection Agency's (U.S. EPA's) Office of Research and Development (ORD) and the U.S. EPA's Great Lake...

Field Study on Environmental Dredging Residuals: Ashtabula River; Volume I. Final Report

EPA Science Inventory

A partnership was formed in 2006 between the National Risk Management Research Laboratory (NRMRL) and the National Exposure Research Laboratory (NERL) of the U.S. Environmental Protection Agency's (U.S. EPA's) Office of Research and Development (ORD) and U.S. EPA's Great Lakes Na...

40 CFR 46.170 - Fellowship agreement.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Fellowship agreement. 46.170 Section 46... FELLOWSHIPS Award § 46.170 Fellowship agreement. (a) The “Fellowship Agreement” (EPA Form 5770-8) is the written agreement, including amendments, between EPA and you. The fellowship agreement will state the...

40 CFR 46.170 - Fellowship agreement.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Fellowship agreement. 46.170 Section 46... FELLOWSHIPS Award § 46.170 Fellowship agreement. (a) The “Fellowship Agreement” (EPA Form 5770-8) is the written agreement, including amendments, between EPA and you. The fellowship agreement will state the...

Ecosystem Services - An Emerging Direction for the U.S.EPA

EPA Science Inventory

Forty years ago the United States Environmental Protection Agency (U.S.EPA) was formed to “protect human health and the environment”. In those days the environment was being severely, and obviously, degraded by any number of pollution inputs, and it was clear that a healthy envi...

48 CFR 1552.211-79 - Compliance with EPA Policies for Information Resources Management.

Code of Federal Regulations, 2011 CFR

2011-10-01

... developing systems which will be operating on the Agency's national platforms must comply with procedures... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Compliance with EPA... Regulations System ENVIRONMENTAL PROTECTION AGENCY CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT...

75 FR 44790 - Second Draft Document Related to the Review of the National Ambient Air Quality Standards for...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-29

... characters, any form of encryption, and be free of any defects or viruses. Docket: All documents in the... EPA's TTN website at: http://www.epa.gov/ttn/naaqs/standards/pm/s_pm_2007_pa.html . The draft document...

77 FR 13061 - Electronic Reporting of Toxics Release Inventory Data

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-05

...--Reporting Year SIC--Standard Industrial Code TRI--Toxics Release Inventory TRI-ME--TRI-Made Easy Desktop... EPA to ``publish a uniform toxic chemical release form for facilities covered'' by the TRI Program. 42... practicable. Similarly, EPA's Cross-Media Electronic Reporting Regulation (CROMERR) (40 CFR Part 3), published...

77 FR 31610 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-29

... online viewing at http://www.regulations.gov , or in person viewing at the Air and Radiation Docket, in the EPA Docket Center (EPA/DC), EPA West, Room 3334, 1301 Constitution Ave. NW., Washington, DC. Joe...

77 FR 55470 - Agency Information Collection Activities; Proposed Collection; Comment Request; Reporting and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-10

....regulations.gov Web site is an ``anonymous access'' system, which means EPA will not know your identity or... , or in person at the Air and Radiation Docket in the EPA Docket Center (EPA/DC), EPA West, Room 3334...: This ICR will expire on 02/28/2013. An agency may not conduct or sponsor, and a person is not required...

78 FR 36777 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-19

... either public viewing online at http://www.regulations.gov , or in person viewing at the Enforcement and Compliance Docket in the EPA Docket Center (EPA/ DC), EPA West, Room 3334, 1301 Constitution Avenue NW, Washington, DC. The EPA Docket Center Public Reading Room is open from 8:30 a.m. to 4:30 p.m., Monday through...

77 FR 18245 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-27

..., which is available for online viewing at www.regulations.gov , or in person viewing at the OEI Docket in the EPA Docket Center (EPA/DC), EPA West, Room 3334, 1301 Constitution Ave. NW., Washington, DC. The EPA/DC Public Reading Room is open from 8:30 a.m. to 4:30 p.m., Monday through Friday, excluding legal...

76 FR 26720 - Science Advisory Board Staff Office; Notification of a Public Teleconference of the Chartered...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-09

... contact Dr. Stallworth preferably at least ten days prior to the teleconference to give EPA as much time... information concerning the EPA Science Advisory Board can be found on the EPA Web site at http://www.epa.gov... report. Background information about this SAB advisory activity can be found on the SAB Web site at http...

Notification: Oversight of Superfund State Contracts for Remedial Activities

EPA Pesticide Factsheets

Project #OA-FY15-0054, December 30, 2014. The Office of Inspector General (OIG) for the U.S. Environmental Protection Agency (EPA) is beginning an audit of the EPA's oversight of Superfund State Contracts (SSCs) for remedial activities.

EPA blocks TNF-α-induced inhibition of sugar uptake in Caco-2 cells via GPR120 and AMPK.

PubMed

Castilla-Madrigal, Rosa; Barrenetxe, Jaione; Moreno-Aliaga, María J; Lostao, María Pilar

2018-03-01

The aim of the present work was to investigate in Caco-2 cells whether eicosapentaenoic acid (EPA), an omega-3 polyunsaturated fatty acid, could block the inhibitory effect of tumor necrosis factor-α (TNF-α) on sugar transport, and identify the intracellular signaling pathways involved. After pre-incubation of the Caco-2 cells with TNF-α and EPA for 1 hr, EPA prevented the inhibitory effect of the cytokine on α-methyl-d-glucose (αMG) uptake (15 min) and on SGLT1 expression at the brush border membrane, measured by Western blot. The ERK1/2 inhibitor PD98059 and the AMPK activator AICAR also prevented the inhibitory effect of TNF-α on both αMG uptake and SGLT1 expression. Interestingly, the AMPK inhibitor, Compound C, abolished the ability of EPA to prevent TNF-α-induced reduction of sugar uptake and transporter expression. The GPR120 antagonist, AH7614, also blocked the preventive effect of EPA on TNF-α-induced decrease of αMG uptake and AMPK phosphorylation. In summary, TNF-α inhibits αMG uptake by decreasing SGLT1 expression in the brush border membrane through the activation of ERK1/2 pathway. EPA prevents the inhibitory effect of TNF-α through the involvement of GPR120 and AMPK activation. © 2017 Wiley Periodicals, Inc.

Amphibian (Xenopus sp.) iodothyronine deiodinase ...

EPA Pesticide Factsheets

The U.S. EPA-MED amphibian thyroid group is currently screening chemicals for inhibition of human iodothyronine deiodinase activity as components of the thyroid system important in human development. Amphibians are a bellwether taxonomic group to gauge toxicity of chemicals in the environment. Amphibian thyroid function is not only important in development but also metamorphosis. Xenopus sp. have been used extensively as model organisms and are well characterized genetically. We propose to screen a list of chemicals (selected from the human DIO screening results) to test for inhibition of Xenopus deiodinases. Large quantities of the enzymes will be produced using an adenovirus system. Our preliminary results show that there may be catalytic differences between human and Xenopus deiodinases. The Twin Ports Early Career Scientists is a new group formed within the Duluth-Superior scientific community. This presentation will provide a basic introduction to my research and our mission at EPA, and help to establish networking and collaboration relationships across disciplines and institutions.

Developing End-of-Training Entrustable Professional Activities for Psychiatry: Results and Methodological Lessons.

PubMed

Young, John Q; Hasser, Caitlin; Hung, Erick K; Kusz, Martin; O'Sullivan, Patricia S; Stewart, Colin; Weiss, Andrea; Williams, Nancy

2018-07-01

To develop entrustable professional activities (EPAs) for psychiatry and to demonstrate an innovative, validity-enhancing methodology that may be relevant to other specialties. A national task force employed a three-stage process from May 2014 to February 2017 to develop EPAs for psychiatry. In stage 1, the task force used an iterative consensus-driven process to construct proposed EPAs. Each included a title, full description, and relevant competencies. In stage 2, the task force interviewed four nonpsychiatric experts in EPAs and further revised the EPAs. In stage 3, the task force performed a Delphi study of national experts in psychiatric education and assessment. All survey participants completed a brief training program on EPAs. Quantitative and qualitative analysis led to further modifications. Essentialness was measured on a five-point scale. EPAs were included if the content validity index was at least 0.8 and the lower end of the asymmetric confidence interval was not lower than 4.0. Stages 1 and 2 yielded 24 and 14 EPAs, respectively. In stage 3, 31 of the 39 invited experts participated in both rounds of the Delphi study. Round 1 reduced the proposed EPAs to 13. Ten EPAs met the inclusion criteria in Round 2. The final EPAs provide a strong foundation for competency-based assessment in psychiatry. Methodological features such as critique by nonpsychiatry experts, a national Delphi study with frame-of-reference training, and stringent inclusion criteria strengthen the content validity of the findings and may serve as a model for future efforts in other specialties.

USE OF QSPRS IN IMPROVING CARBON ADSORPTION MODELING OF EPA CONTAMINANT CANDIDATE COMPOUNDS

EPA Science Inventory

Activated carbon adsorption of EPA contaminant candidate list (CCL) compounds is under investigation as a treatment technology for contaminated drinking water. Historically, EPA, in support of drinking water regulations, has used a number of techniques to calculate field-scale c...

The Effects of EPA, DHA, and Aspirin Ingestion on Plasma Lysophospholipids and Autotaxin

PubMed Central

Block, RC; Duff, R; Lawrence, P; Kakinami, L; Brenna, JT; Shearer, GC; Meednu, N; Mousa, S; Friedman, A; Harris, WS; Larson, Mark; Georas, S

2010-01-01

SUMMARY Lysophophatidylcholine (LPC) and lysophosphatidic acid (LPA) are potent lysolipid mediators increasingly linked with atherosclerosis and inflammation. A current model proposing that plasma LPA is produced when LPC is hydrolyzed by the enzyme autotaxin has not been rigorously investigated in human subjects. We conducted a clinical trial of eicosapentaenoic acid/docosahexaenoic acid (EPA/DHA) and aspirin ingestion in normal volunteers. Fasting blood samples were drawn at baseline and after 4-week supplementation with EPA/DHA (3.4 g/d) with and without aspirin (650 mg). Plasma LPC and LPA species and autotaxin activity were measured. EPA-LPC and DHA-LPC concentrations increased significantly with EPA/DHA supplementation whereas EPA- and DHA-LPA did not. Autotaxin activity was unaffected by any treatment, and aspirin had no effect on any endpoint. Taken together, our data demonstrate that plasma LPC, but not LPA, species can be dynamically regulated by dietary supplementation, and argue against a simple model of LPA generation via LPC hydrolysis. PMID:20106646

EnviroAtlas - Austin, TX - Demographics by Block Group Web Service

EPA Pesticide Factsheets

This EnviroAtlas web service supports research and online mapping activities related to EnviroAtlas (https://enviroatlas.epa.gov/EnviroAtlas). This EnviroAtlas dataset is a summary of key demographic groups for the EnviroAtlas community. This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can be found in its associated EnviroAtlas Fact Sheet (https://www.epa.gov/enviroatlas/enviroatlas-fact-sheets).

EnviroAtlas National Layers Master Web Service

EPA Pesticide Factsheets

This EnviroAtlas web service supports research and online mapping activities related to EnviroAtlas (https://www.epa.gov/enviroatlas). This web service includes layers depicting EnviroAtlas national metrics mapped at the 12-digit HUC within the conterminous United States. This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can be found in its associated EnviroAtlas Fact Sheet (https://www.epa.gov/enviroatlas/enviroatlas-fact-sheets).

Transfer Student Success: Educationally Purposeful Activities Predictive of Undergraduate GPA

ERIC Educational Resources Information Center

Fauria, Renee M.; Fuller, Matthew B.

2015-01-01

Researchers evaluated the effects of Educationally Purposeful Activities (EPAs) on transfer and nontransfer students' cumulative GPAs. Hierarchical, linear, and multiple regression models yielded seven statistically significant educationally purposeful items that influenced undergraduate student GPAs. Statistically significant positive EPAs for…

Cumulative Risk Assessment: Overview of Agency Guidance, Practice and Current Major Research Activities

EPA Science Inventory

Powerpoint presentation that includes the EPA's definition of CRA, relevant publications already in existence, the CRA Guidelines effort, science issues where research is still needed, program office practices related to CRA, and EPA research activities.

75 FR 9407 - Agency Information Collection Activities; Proposed Collection; Comment Request; Implementation of...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-02

... Participation Survey; EPA ICR No. 2375.01 OMB Control No. 2060-New AGENCY: Environmental Protection Agency (EPA... No. 2060-New. ICR status: This ICR is for a new information collection activity. An Agency may not...

75 FR 5785 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-04

... Activities; Submission to OMB for Review and Approval; Comment Request; NESHAP for Site Remediation, EPA ICR... electronic docket, go to http://www.regulations.gov . Title: NESHAP for Site Remediation. ICR Numbers: EPA.... Abstract: 40 CFR part 63, subpart GGGGG, applies to site remediation activities to cleanup materials...

Validity of Level of Supervision Scales for Assessing Pediatric Fellows on the Common Pediatric Subspecialty Entrustable Professional Activities.

PubMed

Mink, Richard B; Schwartz, Alan; Herman, Bruce E; Turner, David A; Curran, Megan L; Myers, Angela; Hsu, Deborah C; Kesselheim, Jennifer C; Carraccio, Carol L

2018-02-01

Entrustable professional activities (EPAs) represent the routine and essential activities that physicians perform in practice. Although some level of supervision scales have been proposed, they have not been validated. In this study, the investigators created level of supervision scales for EPAs common to the pediatric subspecialties and then examined their validity in a study conducted by the Subspecialty Pediatrics Investigator Network (SPIN). SPIN Steering Committee members used a modified Delphi process to develop unique scales for six of the seven common EPAs. The investigators sought validity evidence in a multisubspecialty study in which pediatric fellowship program directors and Clinical Competency Committees used the scales to evaluate fellows in fall 2014 and spring 2015. Separate scales for the six EPAs, each with five levels of progressive entrustment, were created. In both fall and spring, more than 300 fellows in each year of training from over 200 programs were assessed. In both periods and for each EPA, there was a progressive increase in entrustment levels, with second-year fellows rated higher than first-year fellows (P < .001) and third-year fellows rated higher than second-year fellows (P < .001). For each EPA, spring ratings were higher (P < .001) than those in the fall. Interrater reliability was high (Janson and Olsson's iota = 0.73). The supervision scales developed for these six common pediatric subspecialty EPAs demonstrated strong validity evidence for use in EPA-based assessment of pediatric fellows. They may also inform the development of scales in other specialties.

78 FR 13051 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-26

... purposes of collecting, validating, and verifying information, processing and maintaining information, and... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OECA-2012-0693; FRL-9528-5] Agency Information Collection... Processing (Renewal), EPA ICR Number 2050.05 AGENCY: Environmental Protection Agency (EPA). ACTION: Notice...

Report of the CIRRPC Executive Committee regarding EPA NESHAP regulations on radionuclides for medical research institutions and radiopharmaceutical manufacturers

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1990-06-01

There appears to be no compelling public health protection reason for EPA`s promulgation of NESHAP regulations to control air emissions of radioactive materials from NRC-licensed facilities engaged in activities associated with the practice and development of nuclear medicine. The NRC`s existing regulations provide the necessary controls for protection and EPA`s regulations would only add burdensome reporting requirements at substantial cost to medical treatment and diagnosis. Availability of nuclear medicine practice could be impacted and advancements through research delayed.

DOE Office of Scientific and Technical Information (OSTI.GOV)

McLing, Travis; Carpenter, Michael; Brandon, William

The Environmental Protection Agency (EPA) has teamed with Battelle Energy Alliance, LLC (BEA) at Idaho National Laboratory (INL) to facilitate further testing of geologic-fracture-identification methodology at a field site near the Monsanto Superfund Site located in Soda Springs, Idaho. INL has the necessary testing and technological expertise to perform this work. Battelle Memorial Institute (BMI) has engaged INL to perform this work through a Work for Others (WFO) Agreement. This study continues a multi-year collaborative effort between INL and EPA to test the efficacy of using field deployed Cr-39 radon in soil portals. This research enables identification of active fracturesmore » capable of transporting contaminants at sites where fractures are suspected pathways into the subsurface. Current state of the art methods for mapping fracture networks are exceedingly expensive and notoriously inaccurate. The proposed WFO will evaluate the applicability of using cheap, readily available, passive radon detectors to identify conductive geologic structures (i.e. fractures, and fracture networks) in the subsurface that control the transport of contaminants at fracture-dominated sites. The proposed WFO utilizes proven off-the-shelf technology in the form of CR-39 radon detectors, which have been widely deployed to detect radon levels in homes and businesses. In an existing collaborative EPA/INL study outside of this workscope,. CR-39 detectors are being utilized to determine the location of active transport fractures in a fractured granitic upland adjacent to a landfill site at the Fort Devens, MA that EPA-designated as National Priorities List (NPL) site. The innovative concept of using an easily deployed port that allows the CR-39 to measure the Rn-222 in the soil or alluvium above the fractured rock, while restricting atmospheric Rn-222 and soil sourced Ra from contaminating the detector is unique to INL and EPA approach previously developed. By deploying a series of these inexpensive detector-casing combinations statistical samples of the Rn-222 flux can be measured, elucidating the most communicative fractures (i.e. fractures that are actively transporting water and gasses). The Rn-222 measurements can then be used as an input to create a more accurate conceptual model to be used for transport modeling and related cleanup activities. If the team’s approach is demonstrated to be applicable to a wide variety of rock types and soil conditions it might potentially offer significant cost saving without a reduction in data quality at Monsanto Superfund and other sites underlain by fracture-dominated bedrock.« less

EPA ASSESSMENT OF TECHNOLOGIES FOR CONTROLLING EMISSIONS FROM MUNICIPAL WASTE COMBUSTION

EPA Science Inventory

The article examines EPA technical activities relating to the development of regulations pertaining to the control of both new and existing municipal waste combustion facilities (MWCs). The activities include: (1) assessing combustion and flue gas cleaning technologies, (2) colle...

2017 Correspondence between EPA and Oil and Gas Associations about EPA Compliance Assurance Activities

EPA Pesticide Factsheets

In April 2017, various oil and gas industry associations in the western U.S. expressed their concerns to us about our compliance assurance activities. View their letters and memos to us, and our July 2017 responses.

76 FR 6782 - Agency Information Collection Activities; Proposed Collection; Comment Request; Information...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-08

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-SFUND-2011-0052; FRL-9263-6] Agency Information Collection Activities; Proposed Collection; Comment Request; Information Collection Request for Superfund Site Evaluation and Hazard Ranking System AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY...

Entrustable professional activity (EPA) reshapes the practice of specialist training.

PubMed

Niemi-Murola, Leila

In addition to medical expertise, competence-based medical training comprises communication and collaboration skills, professionalism, and leadership skills. Continuous feedback is essential for learning and development, and feedback only from the medical specialist examination taken in the end of training does not ensure thorough specialist training. Entrustable professional activity (EPA) is a unit of professional practice, defined as tasks or responsibilities typical of the specialty. EPA translates competence-based training into manageable and meaningful entities and provides tools for the evaluation of medical competence.

Update on the management of severe hypertriglyceridemia--focus on free fatty acid forms of omega-3.

PubMed

Pirillo, Angela; Catapano, Alberico Luigi

2015-01-01

High levels of plasma triglycerides (TG) are a risk factor for cardiovascular diseases, often associated with anomalies in other lipids or lipoproteins. Hypertriglyceridemia (HTG), particularly at very high levels, significantly increases also the risk of acute pancreatitis. Thus, interventions to lower TG levels are required to reduce the risk of pancreatitis and cardiovascular disease. Several strategies may be adopted for TG reduction, including lifestyle changes and pharmacological interventions. Among the available drugs, the most commonly used for HTG are fibrates, nicotinic acid, and omega-3 polyunsaturated fatty acids (usually a mixture of eicosapentaenoic acid, or EPA, and docosahexaenoic acid, or DHA). These last are available under different concentrated formulations containing high amounts of omega-3 fatty acids, including a mixture of EPA and DHA or pure EPA. The most recent formulation contains a free fatty acid (FFA) form of EPA and DHA, and exhibits a significantly higher bioavailability compared with the ethyl ester forms contained in the other formulations. This is due to the fact that the ethyl ester forms, to be absorbed, need to be hydrolyzed by the pancreatic enzymes that are secreted in response to fat intake, while the FFA do not. This higher bioavailability translates into a higher TG-lowering efficacy compared with the ethyl ester forms at equivalent doses. Omega-3 FFA are effective in reducing TG levels and other lipids in hypertriglyceridemic patients as well as in high cardiovascular risk patients treated with statins and residual HTG. Currently, omega-3 FFA formulation is under evaluation to establish whether, in high cardiovascular risk subjects, the addition of omega-3 to statin therapy may prevent or reduce major cardiovascular events.

40 CFR 147.1651 - EPA-administered program.

Code of Federal Regulations, 2010 CFR

2010-07-01

... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS New York § 147.1651 EPA-administered program. (a) Contents. The UIC program for the State of New York, including all... effective date of the UIC program for New York for all injection activities except those on lands of the...

75 FR 43974 - Agency Information Collection Activities; Proposed Collection; Comment Request; Procedures for...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-27

... Policy Act and Assessing the Environmental Effects Abroad of EPA Actions (Renewal); EPA ICR No. 2243.06... National Environmental Policy Act and Assessing the Environmental Effects Abroad of EPA Actions (Renewal... ``Procedures for Implementing the National Environmental Policy Act and Assessing the Environmental Effects...

75 FR 2535 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-15

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OW-2006-0394; FRL-9103-7; EPA ICR No. 1569.07; OMB Control...; Comment Request; Approval of State Coastal Nonpoint Pollution Control Programs (Renewal) AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: In compliance with the Paperwork Reduction Act...

75 FR 4064 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-26

...., Washington, DC 20503. FOR FURTHER INFORMATION CONTACT: Nell Orscheln, Oceans and Coastal Protection Division... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OW-2006-0369; FRL-9107-1] Agency Information Collection...); EPA ICR No. 1500.07, OMB Control No. 2040-0138 AGENCY: Environmental Protection Agency (EPA). ACTION...

Report: EPA Has Implemented Corrective Actions to Improve Conditions at Asheville, North Carolina Superfund Site

EPA Pesticide Factsheets

Report #12-P-0362, March 21, 2012. Region 4 took actions to implement all recommendations made in EPA OIG Report No. 10-P-0130, EPA Activities Provide Limited Assurance of the Extent of Contamination and Risk at a North Carolina Hazardous Waste Site.

76 FR 9776 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-22

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OAR-2007-0069; FRL-9269-2] Agency Information Collection...: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: In compliance with the Paperwork Reduction [email protected] , or by mail to: EPA Docket Center, Environmental Protection Agency, Air and...

76 FR 67182 - Agency Information Collection Activities; Proposed Collection; Comment Request; Background Checks...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-31

... Employees (Renewal) and Drug Testing for Contract Employees (Renewal) AGENCY: Environmental Protection...: EPA-HQ-OARM-2-11-0804, Drug Testing for Contractor Employees. Hand Delivery: EPA Docket Center... provide qualified personnel that meet the background check and drug testing requirements developed by EPA...

Research Funding Set for NSF, NASA, EPA.

ERIC Educational Resources Information Center

Chemical and Engineering News, 1982

1982-01-01

Funds (1983) for National Science Foundation (NSF), National Aeronautics and Space Administration (NASA), and Environmental Protection Agency (EPA) research programs include $1,092,200,000 (NSF), $5.5 billion (NASA), and $119 million (EPA). NSF's science education activities were raised to $30 million in spite of the Administration's plan to phase…

76 FR 80932 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-27

... Source Water Protection (Renewal) AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY... and cost. DATES: Additional comments may be submitted on or before January 26, 2012. ADDRESSES: Submit..., Environmental Protection Agency, Water Docket, Environmental Protection Agency, EPA Docket Center (EPA/DC...

Proteolytic and Trypsin Inhibitor Activity in Germinating Jojoba Seeds (Simmondsia chinensis).

PubMed

Samac, D; Storey, R

1981-12-01

Changes in proteolytic activity (aminopeptidase, carboxypeptidase, endopeptidase) were followed during germination (imbibition through seedling development) in extracts from cotyledons of jojoba seeds (Simmondsia chinensis). After imbibition, the cotyledons contained high levels of sulfhydryl aminopeptidase activity (APA) but low levels of serine carboxypeptidase activity (CPA). CPA increased with germination through the apparent loss of a CPA inhibitor substance in the seed. Curves showing changes in endopeptidase activity (EPA) assayed at pH 4, 5, 6, 7, and 8 during germination were distinctly different. EPA at pH 4, 5, 6, and 7 showed characteristics of sulfhydryl enzymes while activity at pH 8 was probably due to a serine type enzyme. EPA at pH 6 was inhibited early in germination by one or more substances in the seed. Activities at pH 5 and later at pH 6 were the highest of all EPA throughout germination and increases in these activities were associated with a rapid loss of protein from the cotyledons of the developing seedling.Jojoba cotyledonary extracts were found to inhibit the enzymic activity of trypsin, chymotrypsin, and pepsin but not the protease from Aspergillus saotoi. The heat-labile trypsin inhibitor substance(s) was found in commercially processed jojoba seed meal and the albumin fraction of seed proteins. Trypsin inhibitor activity decreased with germination.

Proteolytic and Trypsin Inhibitor Activity in Germinating Jojoba Seeds (Simmondsia chinensis) 1

PubMed Central

Samac, Deborah; Storey, Richard

1981-01-01

Changes in proteolytic activity (aminopeptidase, carboxypeptidase, endopeptidase) were followed during germination (imbibition through seedling development) in extracts from cotyledons of jojoba seeds (Simmondsia chinensis). After imbibition, the cotyledons contained high levels of sulfhydryl aminopeptidase activity (APA) but low levels of serine carboxypeptidase activity (CPA). CPA increased with germination through the apparent loss of a CPA inhibitor substance in the seed. Curves showing changes in endopeptidase activity (EPA) assayed at pH 4, 5, 6, 7, and 8 during germination were distinctly different. EPA at pH 4, 5, 6, and 7 showed characteristics of sulfhydryl enzymes while activity at pH 8 was probably due to a serine type enzyme. EPA at pH 6 was inhibited early in germination by one or more substances in the seed. Activities at pH 5 and later at pH 6 were the highest of all EPA throughout germination and increases in these activities were associated with a rapid loss of protein from the cotyledons of the developing seedling. Jojoba cotyledonary extracts were found to inhibit the enzymic activity of trypsin, chymotrypsin, and pepsin but not the protease from Aspergillus saotoi. The heat-labile trypsin inhibitor substance(s) was found in commercially processed jojoba seed meal and the albumin fraction of seed proteins. Trypsin inhibitor activity decreased with germination. PMID:16662104

Comparison of polyunsaturated fatty acids content in filets of anadromous and landlocked sockeye salmon Oncorhynchus nerka.

PubMed

Gladyshev, Michail I; Lepskaya, Ekaterina V; Sushchik, Nadezhda N; Makhutova, Olesia N; Kalachova, Galina S; Malyshevskaya, Kseniya K; Markevich, Grigory N

2012-12-01

Fatty acid composition and content of 2 forms of sockeye salmon Oncorhynchus nerka from lakes in Kamchatka Peninsula (Russia) were compared. One form of sockeye salmon was anadromous ("marine"), that is, adult fish migrated in ocean to feed and grow and than return in the lake to breed. Fish of another form, kokanee, never migrate in the ocean. Per cent levels of the main indicators of nutritive value, eicosapentaenoic acid (EPA, 20:5n-3), and docosahexaenoic acid (DHA, 22:6n-3), were significantly higher in the landlocked O. nerka. However, concentrations of EPA and DHA per wet weight of filets were higher in the marine form, because of the relatively higher content of sum of fatty acids in their muscle tissue. As concluded, fish fed in marine environment had higher contents of long-chain n-3 fatty acids per wet weight than fish of the same species, fed in fresh waters. In general, both the anadromous sockeye salmon and the landlocked kokanee salmon can be recommended for human diet as a valuable product concerning contents of EPA and DHA. © 2012 Institute of Food Technologists®

Eicosapentaenoic acid inhibits oxidation of high density lipoprotein particles in a manner distinct from docosahexaenoic acid.

PubMed

Sherratt, Samuel C R; Mason, R Preston

2018-02-05

The omega-3 fatty acid eicosapentaenoic acid (EPA) reduces oxidation of ApoB-containing particles in vitro and in patients with hypertriglyceridemia. EPA may produce these effects through a potent antioxidant mechanism, which may facilitate LDL clearance and slow plaque progression. We hypothesize that EPA antioxidant effects may extend to ApoA-containing particles like HDL, potentially preserving certain atheroprotective functions. HDL was isolated from human plasma and incubated at 37 °C in the absence (vehicle) or presence of EPA and/or DHA; 5.0 or 10.0 μM each. Samples were then subjected to copper-induced oxidation (10 μM). HDL oxidation was inhibited similarly by EPA and DHA up to 1 h. EPA (10 μM) maintained significant HDL oxidation inhibition of 89% (0.622 ± 0.066 μM MDA; p < .001) at 4 h, with continued inhibition of 64% at 14 h, vs. vehicle (5.65 ± 0.06 to 2.01 ± 0.10 μM MDA; p < .001). Conversely, DHA (10 μM) antioxidant benefit was lost by 4 h. At a lower concentration (5 μM), EPA antioxidant activity remained at 81% (5.53 ± 0.15 to 1.03 ± 0.10 μM MDA; p < .001) at 6 h, while DHA lost all antioxidant activity by 4 h. The antioxidant activity of EPA was preserved when combined with an equimolar concentration of DHA (5 μM each). EPA pretreatment prevented HDL oxidation in a dose-dependent manner that was preserved over time. These results suggest unique lipophilic and electron stabilization properties for EPA as compared to DHA with respect to inhibition of HDL oxidation. These antioxidant effects of EPA may enhance certain atheroprotective functions for HDL. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

Waste Acceptance Testing of Secondary Waste Forms: Cast Stone, Ceramicrete and DuraLith

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mattigod, Shas V.; Westsik, Joseph H.; Chung, Chul-Woo

2011-08-12

To support the selection of a waste form for the liquid secondary wastes from WTP, Washington River Protection Solutions has initiated secondary-waste-form testing work at Pacific Northwest National Laboratory (PNNL). In anticipation of a down-selection process for a waste form for the Solidification Treatment Unit to be added to the ETF, PNNL is conducting tests on four candidate waste forms to evaluate their ability to meet potential waste acceptance criteria for immobilized secondary wastes that would be placed in the IDF. All three waste forms demonstrated compressive strengths above the minimum 3.45 MPa (500 psi) set as a target formore » cement-based waste forms. Further, none of the waste forms showed any significant degradation in compressive strength after undergoing thermal cycling (30 cycles in a 10 day period) between -40 C and 60 C or water immersion for 90 days. The three leach test methods are intended to measure the diffusion rates of contaminants from the waste forms. Results are reported in terms of diffusion coefficients and a leachability index (LI) calculated based on the diffusion coefficients. A smaller diffusion coefficient and a larger LI are desired. The NRC, in its Waste Form Technical Position (NRC 1991), provides recommendations and guidance regarding methods to demonstrate waste stability for land disposal of radioactive waste. Included is a recommendation to conduct leach tests using the ANS 16.1 method. The resulting leachability index (LI) should be greater than 6.0. For Hanford secondary wastes, the LI > 6.0 criterion applies to sodium leached from the waste form. For technetium and iodine, higher targets of LI > 9 for Tc and LI > 11 for iodine have been set based on early waste-disposal risk and performance assessment analyses. The results of these three leach tests conducted for a total time between 11days (ASTM C1308) to 90 days (ANS 16.1) showed: (1) Technetium diffusivity: ANSI/ANS 16.1, ASTM C1308, and EPA 1315 tests indicated that all the waste forms had leachability indices better than the target LI > 9 for technetium; (2) Rhenium diffusivity: Cast Stone 2M specimens, when tested using EPA 1315 protocol, had leachability indices better than the target LI > 9 for technetium based on rhenium as a surrogate for technetium. All other waste forms tested by ANSI/ANS 16.1, ASTM C1308, and EPA 1315 test methods had leachability indices that were below the target LI > 9 for Tc based on rhenium release. These studies indicated that use of Re(VII) as a surrogate for 99Tc(VII) in low temperature secondary waste forms containing reductants will provide overestimated diffusivity values for 99Tc. Therefore, it is not appropriate to use Re as a surrogate 99Tc in future low temperature waste form studies. (3) Iodine diffusivity: ANSI/ANS 16.1, ASTM C1308, and EPA 1315 tests indicated that the three waste forms had leachability indices that were below the target LI > 11 for iodine. Therefore, it may be necessary to use a more effective sequestering material than silver zeolite used in two of the waste forms (Ceramicrete and DuraLith); (4) Sodium diffusivity: All the waste form specimens tested by the three leach methods (ANSI/ANS 16.1, ASTM C1308, and EPA 1315) exceeded the target LI value of 6; (5) All three leach methods (ANS 16.1, ASTM C1308 and EPA 1315) provided similar 99Tc diffusivity values for both short-time transient diffusivity effects as well as long-term ({approx}90 days) steady diffusivity from each of the three tested waste forms (Cast Stone 2M, Ceramicrete and DuraLith). Therefore, any one of the three methods can be used to determine the contaminant diffusivities from a selected waste form.« less

Eicosapentaenoic acid (EPA) induced apoptosis in HepG2 cells through ROS-Ca(2+)-JNK mitochondrial pathways.

PubMed

Zhang, Yuanyuan; Han, Lirong; Qi, Wentao; Cheng, Dai; Ma, Xiaolei; Hou, Lihua; Cao, Xiaohong; Wang, Chunling

2015-01-24

Eicosapentaenoic acid (EPA), a well-known dietary n-3 PUFAS, has been considered to inhibit proliferation of tumor cells. However, the molecular mechanism related to EPA-induced liver cancer cells apoptosis has not been reported. In this study, we investigated the effect of EPA on HepG2 cells proliferation and apoptosis mechanism through mitochondrial pathways. EPA inhibited proliferation of HepG2 cells in a dose-dependent manner and had no significant effect on the cell viability of humor normal liver L-02 cells. It was found that EPA initially evoked ROS formation, leading to [Ca(2+)]c accumulation and the mitochondrial permeability transition pore (MPTP) opening; EPA-induced HepG2 cells apoptosis was inhibited by N-acetylcysteine (NAC, an inhibitor of ROS), 1,2-bis (2-aminophenoxy) ethane-N,N,N',N'-tetraacetic acid (BAPTA-AM, a chelator of calcium) and CsA (inhibitor of MPTP). The relationship between ROS production, the increase of cytoplasmic Ca and MPTP opening was detected. It seems that ROS may act as an upstream regulator of EPA-induced [Ca(2+)]c generation, moreover, generation of ROS, overload of mitochondrial [Ca(2+)]c, and JNK activated cause the opening of MPTP. Western blotting results showed that EPA elevated the phosphorylation status of JNK, processes associated with the ROS generation. Simultaneously, the apoptosis induced by EPA was related to release of cytochrome C from mitochondria to cytoplasm through the MPTP and activation of caspase-9 and caspase-3. These results suggest that EPA induces apoptosis through ROS-Ca(2+)-JNK mitochondrial pathways. Copyright © 2014 Elsevier Inc. All rights reserved.

Evaluation of suppressive and pro-resolving effects of EPA and DHA in human primary monocytes and T-helper cells[S

PubMed Central

Jaudszus, Anke; Gruen, Michael; Watzl, Bernhard; Ness, Christina; Roth, Alexander; Lochner, Alfred; Barz, Dagmar; Gabriel, Holger; Rothe, Michael; Jahreis, Gerhard

2013-01-01

Despite their beneficial anti-inflammatory properties, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) may increase the infection risk at high doses, likely by generating an immune-depressed state. To assess the contribution of different immune cell populations to the immunomodulatory fatty acid effect, we comparatively investigated several aspects of inflammation in human T-helper (Th) cells and monocytes. Both fatty acids, but DHA to a lesser extent compared with EPA, selectively and dose-dependently reduced the percentage of cytokine-expressing Th cells in a peroxisome proliferator-activated receptor (PPAR)γ-dependent fashion, whereas the expression of the cell surface marker CD69 was unaltered on activated T cells. In monocytes, both EPA and DHA increased interleukin (IL)-10 without affecting tumor necrosis factor (TNF)-α and IL-6. Cellular incorporation of EPA and DHA occurred mainly at the expense of arachidonic acid. Concomitantly, thromboxane B (TXB)2 and leukotriene B (LTB)4 in supernatants decreased, while levels of TXB3 and LTB5 increased. This increase was independent of activation and in accordance with cyclooxygenase expression patterns in monocytes. Moreover, EPA and DHA gave rise to a variety of mono- and trihydroxy derivatives of highly anti-inflammatory potential, such as resolvins and their precursors. Our results suggest that EPA and DHA do not generally affect immune cell functions in an inhibitory manner but rather promote pro-resolving responses. PMID:23349208

EPA or DHA enhanced oxidative stress and aging protein expression in brain of d-galactose treated mice.

PubMed

Hsu, Yuan-Man; Yin, Mei-Chin

2016-06-01

Effects of eicosapentaenoic acid (EPA, 20:5) and docosahexaenoic acid (DHA, 22:6) upon fatty acid composition, oxidative and inflammatory factors and aging proteins in brain of d-galactose (DG) treated aging mice were examined. Each fatty acid at 7 mg/kg BW/week was supplied for 8 weeks. Brain aging was induced by DG treatment (100 mg/kg body weight) via daily subcutaneous injection for 8 weeks. DG, EPA and DHA treatments changed brain fatty acid composition. DG down-regulated brain Bcl-2 expression and up-regulated Bax expression. Compared with DG groups, EPA and DHA further enhanced Bax expression. DG decreased glutathione content, increased reactive oxygen species (ROS) and oxidized glutathione (GSSG) production, the intake of EPA or DHA caused greater ROS and GSSG formation. DG treatments up-regulated the protein expression of p47(phox) and gp91(phox), and the intake of EPA or DHA led to greater p47(phox) and gp91(phox) expression. DG increased brain prostaglandin E2 (PGE2) levels, and cyclooxygenase (COX)-2 expression and activity, the intake of EPA or DHA reduced brain COX-2 activity and PGE2 formation. DG enhanced brain p53, p16 and p21 expression. EPA and DHA intake led to greater p21 expression, and EPA only caused greater p53 and p16 expression. These findings suggest that these two PUFAs have toxic effects toward aging brain.

Overview of EPA Superfund human health research program.

PubMed

Kowalski, Lorelei; Denne, Jane; Dyer, Robert; Garrahan, Kevin; Wentsel, Randall S

2002-03-01

This paper presents major research needs for the Superfund program, and provides an overview of the EPA Office of Research and Development's (ORDs) current human health research program designed to fill some of those data gaps. Research is presented in terms of the risk paradigm and covers exposure, effects, and assessment activities directly funded by Superfund, as well as research not funded by Superfund but directly applicable to Superfund research needs. Research on risk management is not covered. Current research activities conducted by the Superfund program office are also included to provide a full picture of Superfund human health research activities being conducted by EPA.

40 CFR 710.59 - Availability of reporting form and instructions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... § 710.59 Availability of reporting form and instructions. (a) Use the proper EPA form. You must use the... for the 2006 Partial Updating of the TSCA Chemical Inventory Database,” are available as described in...

75 FR 61486 - Review of the Secondary National Ambient Air Quality Standards for Oxides of Nitrogen and Oxides...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-05

... EPA cannot read your comment due to technical difficulties and cannot contact you for clarification... comments, remember to: Identify the rulemaking by docket number and other identifying information (subject... pollutants in forming the scientific basis for the NAAQS, EPA has decided to jointly assess the science...

40 CFR 60.2235 - In what form can I submit my reports?

Code of Federal Regulations, 2013 CFR

2013-07-01

... with ERT are subject to this requirement to be submitted electronically into EPA's WebFIRE database... tests required by this subpart to EPA's WebFIRE database by using the Compliance and Emissions Data...FIRE Administrator, MD C404-02, 4930 Old Page Rd., Durham, NC 27703. The same ERT file with the CBI...

Highly purified eicosapentaenoic acid ameliorates cardiac injury and adipose tissue inflammation in a rat model of metabolic syndrome

PubMed Central

Ito, S.; Sano, Y.; Nagasawa, K.; Matsuura, N.; Yamada, Y.; Uchinaka, A.; Murohara, T.

2016-01-01

Summary Introduction n‐3 Polyunsaturated fatty acids such as eicosapentaenoic acid (EPA), which are abundant in fish oil, have been shown to delay the onset of cardiovascular events. We previously established DahlS.Z‐Lepr fa/Lepr fa (DS/obese) rats, which are derived from a cross between Dahl salt‐sensitive and Zucker rats, as a model of metabolic syndrome. This study has now explored the influence of highly purified EPA on cardiac and adipose tissue pathophysiology in this animal model. Materials and methods DS/obese rats were administered EPA (300 or 1,000 mg kg−1 d−1, per os) or vehicle from age 9 to 13 weeks. Homozygous lean (DahlS.Z‐Lepr +/Lepr +, or DS/lean) littermates were studied as controls. Results Whereas EPA had no effect on body weight, food intake or systolic blood pressure in DS/obese rats, it attenuated cardiac fibrosis, diastolic dysfunction, oxidative stress and inflammation in these animals. In addition, EPA did not affect insulin resistance but reduced adipocyte hypertrophy and inflammation in visceral fat of DS/obese rats. Moreover, EPA increased circulating levels of adiponectin as well as attenuated both the down‐regulation of AMP‐activated protein kinase phosphorylation and the up‐regulation of phosphorylation of the p65 subunit of nuclear factor‐kB in the heart of DS/obese rats. Conclusions Treatment of DS/obese rats with EPA did not affect hypertension but reduced cardiac fibrosis and diastolic dysfunction, with the latter effects being accompanied by AMP‐activated protein kinase activation and inactivation of nuclear factor‐kB signalling in the heart, possibly as a result of an increase in adiponectin secretion. EPA may be suitable for the treatment of cardiac injury associated with metabolic syndrome. PMID:27708849

Final Project Report for the Development of an Active Soil Gas Sampling Method

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) is charged by Congress with protecting the nation's natural resources. Under the mandate of national environmental laws, the EPA strives to formulate and implement actions leading to a compatible balance between human activities and ...

EPA ACTIVITIES TO PREPARE FOR REGULATORY AND RISK ASSESSMENT APPLICATIONS OF GENOMICS INFORMATION

EPA Science Inventory

Genomics will have significant implications for risk assessment and regulatory decision making. Since 2002, the U.S. EPA has undertaken a number of cross-Agency activities to further prepare itself to receive,interpret and apply genomics information for risk assessment and regul...

AN OVERVIEW OF OECD AND EPA/ORD ACTIVITIES RELATED TO AMPHIBIAN TESTING

EPA Science Inventory

There has been significant recent activity related to testing amphibians in a regulatory setting. Much of this has emanated from interest by the US Environmental Protection Agency (EPA) and the Office of Economic Cooperation and Development (OECD) in utilizing amphibians in scree...

RESEARCH ACTIVITIES AT THE US EPA'S GULF ECOLOGY DIVISION

EPA Science Inventory

The purpose of this talk was to present an overview of research activities at the US EPA's Office of Research and Development, Gulf Ecology Division located on Pensacola Beach, Florida. The talk was organized into three major sections. The first section covered my educational b...

76 FR 4343 - Agency Information Collection Activities; Proposed Collection; Comment Request; Contractor...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-25

...; Contractor Conflicts of Interest AGENCY: Environmental Protection Agency. ACTION: Notice. SUMMARY: In... control numbers in certain EPA regulations is consolidated in 40 CFR part 9. Abstract: EPA contractors... cleanup and enforcement and because its contractors are often involved in both activities, it is...

Comparative Study of Different Polar Groups of EPA-Enriched Phospholipids on Ameliorating Memory Loss and Cognitive Deficiency in Aged SAMP8 Mice.

PubMed

Zhou, Miao-Miao; Che, Hong-Xia; Huang, Jia-Qi; Zhang, Tian-Tian; Xu, Jie; Xue, Chang-Hu; Wang, Yu-Ming

2018-04-01

Recent studies have shown that omega-3 PUFAs enriched phospholipids (n-3 PUFA-PLs) have beneficial effects on memory and cognition. However, most reports only attribute the benefit to docosahexaenoic acid (DHA) and pay little attention to eicosapentaenoic acid (EPA). We investigate the effect of EPA-enriched phospholipids on cognitive deficiency in senescence-accelerated prone 8 (SAMP8) mouse. Ten-month-old SAMP8 mice are fed with 2% (w/w) EPA-enriched phosphatidylcholine/phosphatidyl ethanolamine (EPA-PC/PE; EPA:DHA = 46.8:3.01) or 2% EPA-enriched phosphatidylserine (EPA-PS; biosynthesized from EPA-PC/PE) for 8 weeks; we then test the behavioral performances in the Barnes maze test and Morris maze test; the changes of oxidative stress, apoptosis, neurotrophic factors, tau phosphorylation, and Aβ pathology are also measured. The results of behavior tests indicate that both EPA-PC/PE and EPA-PS significantly improve memory and cognitive deficiency. It is found that remarkable amelioration of oxidative stress and apoptosis occurs in both EPA-PC/PE and EPA-PS groups. EPA-PS shows more ameliorative effects than EPA-PC/PE on neurotrophic activity by decreasing hyper-phosphorylation of tau and depressing the generation and accumulation of β-amyloid peptide (Aβ). These data suggest that EPA-PS exhibits better effects than EPA-PC/PE on ameliorating memory and cognitive function, which might be attributed to the phospholipid polar groups. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

77 FR 27451 - Permitting Guidance for Oil and Gas Hydraulic Fracturing Activities Using Diesel Fuels-Draft...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-10

... authority. The draft guidance includes EPA's interpretation of the Safe Drinking Water Act (SDWA) and...., Washington, DC 20460. Hand Delivery: Office of Water (OW) Docket, EPA/DC, EPA West, Room 3334, 1301... Injection Control Program, Drinking Water Protection Division, Office of Ground Water and Drinking Water (MC...

76 FR 5800 - Agency Information Collection Activities: Proposed Collection; Comment Request

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2011-02-02

....regulations.gov Web site is an ``anonymous access'' system, which means EPA will not know your identity or... renew an existing approved Information Collection Request (ICR) 2258.02-- Implementation of the 1997 and...-566-1741 Mail: Attention Docket ID No. EPA-HQ-OAR-2007-0265, U.S. Environmental Protection Agency, EPA...

77 FR 16831 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

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2012-03-22

...) Greenhouse Gas Inventory Pilot (Renewal) AGENCY: Environmental Protection Agency (EPA). ACTION: Notice... Management and Budget (OMB), Attention: Desk Officer for EPA, 725 17th Street NW., Washington, DC 20503. FOR... (Small Business) Greenhouse Gas Inventory Pilot (Renewal) ICR numbers: EPA ICR No. 2100.05, OMB Control...

75 FR 8055 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

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75 FR 6023 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

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2010-02-05

... Support of EPA's Third Six-Year Review of National Primary Drinking Water Regulations (Renewal); EPA ICR..., Office of Ground Water and Drinking Water, Standards and Risk Management Division (MC 4607M...: Contaminant Occurrence Data in Support of EPA's Third Six- Year Review of National Primary Drinking Water...

7 CFR 650.21 - Working relations with the U.S. Environmental Protection Agency (EPA) and related State...

Code of Federal Regulations, 2010 CFR

2010-01-01

... standards. (iii) Consider EPA needs in soil survey and land, inventory, and monitoring activities. (iv... EIS's. (v) Advise EPA regarding soils, plant materials, and soil and water conservation techniques..., transport of pesticides, organic matter and fertilizers, and burning of residues or clearing debris. (2) The...

7 CFR 650.21 - Working relations with the U.S. Environmental Protection Agency (EPA) and related State...

Code of Federal Regulations, 2012 CFR

2012-01-01

... standards. (iii) Consider EPA needs in soil survey and land, inventory, and monitoring activities. (iv... EIS's. (v) Advise EPA regarding soils, plant materials, and soil and water conservation techniques..., transport of pesticides, organic matter and fertilizers, and burning of residues or clearing debris. (2) The...

7 CFR 650.21 - Working relations with the U.S. Environmental Protection Agency (EPA) and related State...

Code of Federal Regulations, 2011 CFR

2011-01-01

... standards. (iii) Consider EPA needs in soil survey and land, inventory, and monitoring activities. (iv... EIS's. (v) Advise EPA regarding soils, plant materials, and soil and water conservation techniques..., transport of pesticides, organic matter and fertilizers, and burning of residues or clearing debris. (2) The...

7 CFR 650.21 - Working relations with the U.S. Environmental Protection Agency (EPA) and related State...

Code of Federal Regulations, 2014 CFR

2014-01-01

... standards. (iii) Consider EPA needs in soil survey and land, inventory, and monitoring activities. (iv... EIS's. (v) Advise EPA regarding soils, plant materials, and soil and water conservation techniques..., transport of pesticides, organic matter and fertilizers, and burning of residues or clearing debris. (2) The...

7 CFR 650.21 - Working relations with the U.S. Environmental Protection Agency (EPA) and related State...

Code of Federal Regulations, 2013 CFR

2013-01-01

... standards. (iii) Consider EPA needs in soil survey and land, inventory, and monitoring activities. (iv... EIS's. (v) Advise EPA regarding soils, plant materials, and soil and water conservation techniques..., transport of pesticides, organic matter and fertilizers, and burning of residues or clearing debris. (2) The...

40 CFR 721.30 - EPA approval of alternative control measures.

Code of Federal Regulations, 2014 CFR

2014-07-01

... determination of equivalency to EPA under this part must submit the request to EPA via CDX using e-PMN software... to obtain e-PMN software. Support documents related to these requests must be submitted in the manner... submitted. (4) A detailed description of the activities involved. (5) The specifications of the alternative...

Entrustable Professional Activities for Entering Residency: Establishing Common Osteopathic Performance Standards in the Transition From Medical School to Residency.

PubMed

Basehore, Pamela M; Mortensen, Luke H; Katsaros, Emmanuel; Linsenmeyer, Machelle; McClain, Elizabeth K; Sexton, Patricia S; Wadsworth, Nicole

2017-11-01

Entrustable professional activities (EPAs) are measurable units of observable professional practice that can be entrusted to an unsupervised trainee. They were first introduced as a method of operationalizing competency-based medical education in graduate medical education. The American Association of Medical Colleges subsequently used EPAs to establish the core skills that medical students must be able to perform before they enter residency training. A recently published guide provides descriptions, guidelines, and rationale for implementing and assessing the core EPAs from an osteopathic approach. These osteopathically informed EPAs can allow schools to more appropriately assess a learner's whole-person approach to a patient, in alignment with the philosophy of the profession. As the single accreditation system for graduate medical education moves forward, it will be critical to integrate EPAs into osteopathic medical education to demonstrate entrustment of medical school graduates. The authors describe the collaborative process used to establish the osteopathic considerations added to EPAs and explores the challenges and opportunities for undergraduate osteopathic medical education.

Inflammation increases NOTCH1 activity via MMP9 and is counteracted by Eicosapentaenoic Acid-free fatty acid in colon cancer cells

PubMed Central

Fazio, Chiara; Piazzi, Giulia; Vitaglione, Paola; Fogliano, Vincenzo; Munarini, Alessandra; Prossomariti, Anna; Milazzo, Maddalena; D’Angelo, Leonarda; Napolitano, Manuela; Chieco, Pasquale; Belluzzi, Andrea; Bazzoli, Franco; Ricciardiello, Luigi

2016-01-01

Aberrant NOTCH1 signalling is critically involved in multiple models of colorectal cancer (CRC) and a prominent role of NOTCH1 activity during inflammation has emerged. Epithelial to Mesenchymal Transition (EMT), a crucial event promoting malignant transformation, is regulated by inflammation and Metalloproteinase-9 (MMP9) plays an important role in this process. Eicosapentaenoic Acid (EPA), an omega-3 polyunsaturated fatty acid, was shown to prevent colonic tumors in different settings. We recently found that an extra-pure formulation of EPA as Free Fatty Acid (EPA-FFA) protects from colon cancer development in a mouse model of Colitis-Associated Cancer (CAC) through modulation of NOTCH1 signalling. In this study, we exposed colon cancer cells to an inflammatory stimulus represented by a cytokine-enriched Conditioned Medium (CM), obtained from THP1-differentiated macrophages. We found, for the first time, that CM strongly up-regulated NOTCH1 signalling and EMT markers, leading to increased invasiveness. Importantly, NOTCH1 signalling was dependent on MMP9 activity, upon CM exposure. We show that a non-cytotoxic pre-treatment with EPA-FFA antagonizes the effect of inflammation on NOTCH1 signalling, with reduction of MMP9 activity and invasiveness. In conclusion, our data suggest that, in CRC cells, inflammation induces NOTCH1 activity through MMP9 up-regulation and that this mechanism can be counteracted by EPA-FFA. PMID:26864323

Inflammation increases NOTCH1 activity via MMP9 and is counteracted by Eicosapentaenoic Acid-free fatty acid in colon cancer cells.

PubMed

Fazio, Chiara; Piazzi, Giulia; Vitaglione, Paola; Fogliano, Vincenzo; Munarini, Alessandra; Prossomariti, Anna; Milazzo, Maddalena; D'Angelo, Leonarda; Napolitano, Manuela; Chieco, Pasquale; Belluzzi, Andrea; Bazzoli, Franco; Ricciardiello, Luigi

2016-02-11

Aberrant NOTCH1 signalling is critically involved in multiple models of colorectal cancer (CRC) and a prominent role of NOTCH1 activity during inflammation has emerged. Epithelial to Mesenchymal Transition (EMT), a crucial event promoting malignant transformation, is regulated by inflammation and Metalloproteinase-9 (MMP9) plays an important role in this process. Eicosapentaenoic Acid (EPA), an omega-3 polyunsaturated fatty acid, was shown to prevent colonic tumors in different settings. We recently found that an extra-pure formulation of EPA as Free Fatty Acid (EPA-FFA) protects from colon cancer development in a mouse model of Colitis-Associated Cancer (CAC) through modulation of NOTCH1 signalling. In this study, we exposed colon cancer cells to an inflammatory stimulus represented by a cytokine-enriched Conditioned Medium (CM), obtained from THP1-differentiated macrophages. We found, for the first time, that CM strongly up-regulated NOTCH1 signalling and EMT markers, leading to increased invasiveness. Importantly, NOTCH1 signalling was dependent on MMP9 activity, upon CM exposure. We show that a non-cytotoxic pre-treatment with EPA-FFA antagonizes the effect of inflammation on NOTCH1 signalling, with reduction of MMP9 activity and invasiveness. In conclusion, our data suggest that, in CRC cells, inflammation induces NOTCH1 activity through MMP9 up-regulation and that this mechanism can be counteracted by EPA-FFA.

Compliance program data management system for The Idaho National Engineering Laboratory/Environmental Protection Agency

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hertzler, C.L.; Poloski, J.P.; Bates, R.A.

1988-01-01

The Compliance Program Data Management System (DMS) developed at the Idaho National Engineering Laboratory (INEL) validates and maintains the integrity of data collected to support the Consent Order and Compliance Agreement (COCA) between the INEL and the Environmental Protection Agency (EPA). The system uses dBase III Plus programs and dBase III Plus in an interactive mode to enter, store, validate, manage, and retrieve analytical information provided on EPA Contract Laboratory Program (CLP) forms and CLP forms modified to accommodate 40 CFR 264 Appendix IX constituent analyses. Data analysis and presentation is performed utilizing SAS, a statistical analysis software program. Archivingmore » of data and results is performed at appropriate stages of data management. The DMS is useful for sampling and analysis programs where adherence to EPA CLP protocol, along with maintenance and retrieval of waste site investigation sampling results is desired or requested. 3 refs.« less

Report: Decline In EPA Particulate Matter Methods Development Activities May Hamper Timely Achievement of Program Goals

EPA Pesticide Factsheets

Report #2003-P-00016, September 30, 2003. EPA has not supported PM2.5 methods development activities to the extent necessary to fully achieve the short- and long-range goals of the PM2.5 program in a timely manner.

Predictive Toxicology: Current Status and Future Outlook (EBI ...

EPA Pesticide Factsheets

Slide presentation at the EBI-EMBL Industry Programme Workshop on Predictive Toxicology and the currently status of Computational Toxicology activities at the US EPA. Slide presentation at the EBI-EMBL Industry Programme Workshop on Predictive Toxicology and the currently status of Computational Toxicology activities at the US EPA.

76 FR 6780 - Agency Information Collection Activities OMB Responses

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-08

... Action Plan/Activity Integration Plan (CAP/AIP) Reporting System; was approved on 01/06/2011; OMB Number... without change. EPA ICR Number 1445.09; Continuous Release Reporting Regulations (CRRR) under CERCLA; 40... change. EPA ICR Number 1445.10; Continuous Release Reporting Regulations (CRRR) under CERCLA; 40 CFR 302...

75 FR 4809 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-29

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OECA-2009-0494; FRL-9108-2] Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment Request; Tips and Complaints Regarding Environmental Violations; EPA ICR No. 2219.03, OMB Control No. 2020- 0032 AGENCY: Environmental Protection...

76 FR 22891 - Modification to 2008 National Pollutant Discharge Elimination System (NPDES) General Permit for...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-25

... Construction Activities AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: EPA Regions 1... System (NPDES) general permits for stormwater discharges associated with construction activity in order... permits will be referred to as ``permit'' or ``2008 construction general permit'' or ``2008 CGP.'' This...

76 FR 40355 - Modification to 2008 National Pollutant Discharge Elimination System (NPDES) General Permit for...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-08

... Construction Activities AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: EPA Regions 1... (NPDES) general permits for stormwater discharges associated with construction activity in order to... permits will be referred to as ``permit'' or ``2008 construction general permit'' or ``2008 CGP.'' This...

75 FR 4554 - Modification to 2008 National Pollutant Discharge Elimination System (NPDES) General Permit for...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-28

... Construction Activities AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: EPA Regions 1... System (NPDES) general permits for stormwater discharges associated with construction activity in order... will be referred to as ``permit'' or ``2008 construction general permit'' or ``2008 CGP.'' The 2008 CGP...

Recent Developments in Toxico-Cheminformatics; Supporting ...

EPA Pesticide Factsheets

EPA's National Center for Computational Toxicology is building capabilities to support a new paradigm for toxicity screening and prediction through the harnessing of legacy toxicity data, creation of data linkages, and generation of new high-content and high-thoughput screening data. In association with EPA's ToxCast, ToxRefDB, and ACToR projects, the DSSTox project provides cheminformatics support and, in addition, is improving public access to quality structure-annotated chemical toxicity information in less summarized forms than traditionally employed in SAR modeling, and in ways that facilitate data-mining and data read-across. The latest DSSTox version of the Carcinogenic Potency Database file (CPDBAS) illustrates ways in which various summary definitions of carcinogenic activity can be employed in modeling and data mining. DSSTox Structure-Browser provides structure searchability across all published DSSTox toxicity-related inventory, and is enabling linkages between previously isolated toxicity data resources associated with environmental and industrial chemicals. The public DSSTox inventory also has been integrated into PubChem, allowing a user to take full advantage of PubChem structure-activity and bioassay clustering features. Phase I of the ToxCast project is generating high-throughput screening data from several hundred biochemical and cell-based assays for a set of 320 chemicals, mostly pesticide actives with rich toxicology profiles. Incorporating

40 CFR 350.27 - Substantiation form to accompany claims of trade secrecy, instructions to substantiation form.

Code of Federal Regulations, 2010 CFR

2010-07-01

... TRADE SECRET DISCLOSURES TO HEALTH PROFESSIONALS Trade Secrecy Claims § 350.27 Substantiation form to... Secret Substantiation Form General Information EPA requires that the information requested in a trade secret substantiation be completed using this substantiation form in order to ensure that all facility...

40 CFR 350.27 - Substantiation form to accompany claims of trade secrecy, instructions to substantiation form.

Code of Federal Regulations, 2014 CFR

2014-07-01

... TRADE SECRET DISCLOSURES TO HEALTH PROFESSIONALS Trade Secrecy Claims § 350.27 Substantiation form to... Secret Substantiation Form General Information EPA requires that the information requested in a trade secret substantiation be completed using this substantiation form in order to ensure that all facility...

40 CFR 350.27 - Substantiation form to accompany claims of trade secrecy, instructions to substantiation form.

Code of Federal Regulations, 2011 CFR

2011-07-01

... TRADE SECRET DISCLOSURES TO HEALTH PROFESSIONALS Trade Secrecy Claims § 350.27 Substantiation form to... Secret Substantiation Form General Information EPA requires that the information requested in a trade secret substantiation be completed using this substantiation form in order to ensure that all facility...

40 CFR 350.27 - Substantiation form to accompany claims of trade secrecy, instructions to substantiation form.

Code of Federal Regulations, 2012 CFR

2012-07-01

... TRADE SECRET DISCLOSURES TO HEALTH PROFESSIONALS Trade Secrecy Claims § 350.27 Substantiation form to... Secret Substantiation Form General Information EPA requires that the information requested in a trade secret substantiation be completed using this substantiation form in order to ensure that all facility...

40 CFR 350.27 - Substantiation form to accompany claims of trade secrecy, instructions to substantiation form.

Code of Federal Regulations, 2013 CFR

2013-07-01

... TRADE SECRET DISCLOSURES TO HEALTH PROFESSIONALS Trade Secrecy Claims § 350.27 Substantiation form to... Secret Substantiation Form General Information EPA requires that the information requested in a trade secret substantiation be completed using this substantiation form in order to ensure that all facility...

The Omega-3 Fatty Acid Eicosapentaenoic Acid Accelerates Disease Progression in a Model of Amyotrophic Lateral Sclerosis

PubMed Central

Gladman, Stacy; Biggio, Maria Luigia; Marino, Marianna; Jayasinghe, Maduka; Ullah, Farhan; Dyall, Simon C.; Malaspina, Andrea; Bendotti, Caterina; Michael-Titus, Adina

2013-01-01

Amyotrophic lateral sclerosis (ALS) is a progressive fatal neurodegenerative disease characterised by loss of motor neurons that currently has no cure. Omega-3 polyunsaturated fatty acids, such as eicosapentaenoic acid (EPA), have many health benefits including neuroprotective and myoprotective potential. We tested the hypothesis that a high level of dietary EPA could exert beneficial effects in ALS. The dietary exposure to EPA (300 mg/kg/day) in a well-established mouse model of ALS expressing the G93A superoxide dismutase 1 (SOD1) mutation was initiated at a pre-symptomatic or symptomatic stage, and the disease progression was monitored until the end stage. Daily dietary EPA exposure initiated at the disease onset did not significantly alter disease presentation and progression. In contrast, EPA treatment initiated at the pre-symptomatic stage induced a significantly shorter lifespan. In a separate group of animals sacrificed before the end stage, the tissue analysis showed that the vacuolisation detected in G93A-SOD1 mice was significantly increased by exposure to EPA. Although EPA did not alter motor neurone loss, EPA reversed the significant increase in activated microglia and the astrocytic activation seen in G93A-SOD1 mice. The microglia in the spinal cord of G93A-SOD1 mice treated with EPA showed a significant increase in 4-hydroxy-2-hexenal, a highly toxic aldehydic oxidation product of omega-3 fatty acids. These data show that dietary EPA supplementation in ALS has the potential to worsen the condition and accelerate the disease progression. This suggests that great caution should be exerted when considering dietary omega-3 fatty acid supplements in ALS patients. PMID:23620776

Eicosapentaenoic Acid (EPA) Induced Macrophages Activation through GPR120-Mediated Raf-ERK1/2-IKKβ-NF-κB p65 Signaling Pathways

PubMed Central

Han, Lirong; Song, Shumin; Niu, Yabing; Meng, Meng; Wang, Chunling

2017-01-01

Objectives: To investigate the immunomodulatory effect and molecular mechanisms of Eicosapentaenoic acid (EPA, a typical kind of n-3PUFAs) on RAW264.7 cells. Methods: A variety of research methods, including the RAW264.7 cells culture, cell proliferation assays, morphologic observations, measurements of NO production, cytokine assays, nuclear protein extractions, western blot analyses and NF-κB p65 immunofluorescence assays were used in this study. Results: The results showed that EPA could increase the proliferation index and enhance the release of nitric oxide (NO) and cytokines in RAW264.7 cells. Western blotting results revealed that the protein level of GPR120 increased significantly in RAW264.7 cells after EPA treatment. Meanwhile, EPA elevated the phosphorylation status of Raf, which may act as an upstream regulator of EPA-induced phosphorylated ERK1/2. In addition, the phosphorylated ERK1/2 may then promote IKKβ in endochylema and translocate the NF-κB p65 subunit into the nucleus, thus regulating the production of inducible nitric oxide synthase (iNOS) and cytokines. Conclusions: EPA (0.6–3.0 μmol) activates RAW264.7 cells through GPR120-mediated Raf-ERK1/2-IKKβ-NF-κB p65 signaling pathways. PMID:28841192

Eicosapentaenoic Acid (EPA) Induced Macrophages Activation through GPR120-Mediated Raf-ERK1/2-IKKβ-NF-κB p65 Signaling Pathways.

PubMed

Han, Lirong; Song, Shumin; Niu, Yabing; Meng, Meng; Wang, Chunling

2017-08-25

Objectives: To investigate the immunomodulatory effect and molecular mechanisms of Eicosapentaenoic acid (EPA, a typical kind of n-3PUFAs) on RAW264.7 cells. Methods: A variety of research methods, including the RAW264.7 cells culture, cell proliferation assays, morphologic observations, measurements of NO production, cytokine assays, nuclear protein extractions, western blot analyses and NF-κB p65 immunofluorescence assays were used in this study. Results: The results showed that EPA could increase the proliferation index and enhance the release of nitric oxide (NO) and cytokines in RAW264.7 cells. Western blotting results revealed that the protein level of GPR120 increased significantly in RAW264.7 cells after EPA treatment. Meanwhile, EPA elevated the phosphorylation status of Raf, which may act as an upstream regulator of EPA-induced phosphorylated ERK1/2. In addition, the phosphorylated ERK1/2 may then promote IKKβ in endochylema and translocate the NF-κB p65 subunit into the nucleus, thus regulating the production of inducible nitric oxide synthase (iNOS) and cytokines. Conclusions: EPA (0.6-3.0 μmol) activates RAW264.7 cells through GPR120-mediated Raf-ERK1/2-IKKβ-NF-κB p65 signaling pathways.

75 FR 28803 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-24

... INFORMATION CONTACT: Charles M. Petko, Office of Radiation and Indoor Air (ORIA), National Air and Radiation... Protection Agency, Air and Radiation Docket, Mail Code 28221T, 1200 Pennsylvania Ave., NW., Washington, DC... viewing at the Office of Air and Radiation Docket in the EPA Docket Center (EPA/DC), EPA West, Room 3334...

75 FR 47589 - Agency Information Collection Activities; Proposed Collection; Comment Request; Correction of...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-06

... Inventory; EPA ICR No. 1741.06, OMB Control No. 2070-0145 AGENCY: Environmental Protection Agency (EPA... Control Act (TSCA) Inventory and regulated under TSCA section 8, who had reported to the initial effort to...: ``Correction of Misreported Chemical Substances on the TSCA Inventory'' and identified by EPA ICR No. 1741.06...

Operational Range Assessment Program (ORAP) Phase II Overview for Active Installations

DTIC Science & Technology

2011-05-01

Dissolved Metals by EPA 1638M • Isotopic Uranium by EML A-01-R Mod  Sediment Analysis • None  Benthic Macroinvertebrates • Diversity Indices...Metals by EPA 200.8 • Dissolved Metals by EPA 200.8 (if turbid) • Isotopic Uranium by EML A-01- R Mod (if total U is > action limit) Groundwater

Tire Crumb Research Study Literature Review / Gap ...

EPA Pesticide Factsheets

In order to more fully understand data gaps in human exposure and toxicity to tire crumb materials, ATSDR, CPSC and EPA undertook a collaborative effort in the form of a scientific literature review and subsequent gaps analysis. The first objective of the Literature Review and Gap Analysis (LRGA) collaboration was to identify the existing body of literature related specifically to human exposure to tire crumb materials through the use of synthetic turf athletic fields and playgrounds. The second objective was to characterize and summarize the relevant data from the scientific literature. The final objective was to review the summary information and identify data gaps to build on the current understanding of the state-of-the-science and inform the development of specific research efforts that would be most impactful in the near-term. Because of the need for additional information, the U.S. Environmental Protection Agency (EPA), the Centers for Disease Control and Prevention/Agency for Toxic Substances and Disease Registry (ATSDR), and the U.S. Consumer Product Safety Commission (CPSC) launched a multi-agency action plan to study key environmental human health questions. The Federal Research Action Plan includes numerous activities, including research studies (U.S. EPA, 2016). A key objective of the Action Plan is to identify key knowledge gaps.

Meeting Materials for the 4th NRC Meeting on the Guidance for and the Review of EPA's Toxicological Assessment of Inorganic Arsenic

EPA Science Inventory

On December 2-3, 2015, the National Research Council (NRC) hosted the 4th meeting of the committee formed to peer review the draft IRIS assessment of inorganic arsenic. EPA presented background and overview materials during the public session on December 2nd. This information co...

An Examination of the Relationship between Enjoyment, Physical Education, Physical Activity and Health in Irish Adolescents

ERIC Educational Resources Information Center

Woods, Catherine B.; Tannehill, Deborah; Walsh, Julia

2012-01-01

Enjoyment of physical activity (EPA) is positively correlated with activity, yet little is known of its relationship with enjoyment of physical education (EPE). This study's purpose was to explore EPE and its relationship to EPA. Cross-sectional data (N = 4122, average age 14.5 plus or minus 1.7 years, 48% male) were collected as part of the CSPPA…

ChemRad Sample Form Instructions

EPA Pesticide Factsheets

These instructons are intended to assist registered users of the EPA Region 8 Drinking Water Watch website who would like to create ChemRad Sample Forms for monitoring that is required during the current year.

Application Forms for Forestry and Silvicultural Burning Tribal Permits Under the FARR

EPA Pesticide Factsheets

Application form for forestry and silvicultural burning on the Nez Perce Indian Reservation and the Confederated Tribes of the Umatilla Indian Reservation under EPA's Federal Air Rules for Reservations.

76 FR 5366 - Agency Information Collection Activities; Proposed Collection; Comment Request; Significant New...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-31

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OAR-2004-0077; FRL-9259-4] Agency Information Collection Activities; Proposed Collection; Comment Request; Significant New Alternatives Policy (SNAP) Program Final Rulemaking Under Title VI of the Clean Air Act Amendments of 1990; EPA ICR No. 1596.08, OMB Control No. 2060...

75 FR 144 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-04

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OECA-2009-0536; FRL-9100-2] Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment Request; Emission Guidelines and Compliance Times for Municipal Solid Waste Landfills (Renewal); EPA ICR No. 1893.05, OMB Control No. 2060-0430...

Active Ingredient - AZ

EPA Pesticide Factsheets

EPA Pesticide Chemical Search allows a user to easily find the pesticide chemical or active ingredient that they are interested in by using an array of simple to advanced search options. Chemical Search provides a single point of reference for easy access to information previously published in a variety of locations, including various EPA web pages and Regulations.gov.

33 CFR 165.125 - Regulated Navigation Area; EPA Superfund Site, New Bedford Harbor, Massachusetts.

Code of Federal Regulations, 2011 CFR

2011-07-01

... undue risk to environmental remediation efforts. Requests for waivers should be submitted in writing to... vessels or persons engaged in activities associated with remediation efforts in the New Bedford Harbor... advance notice of those activities by the U.S. Environmental Protection Agency (EPA). (c) Waivers. The...

33 CFR 165.125 - Regulated Navigation Area; EPA Superfund Site, New Bedford Harbor, Massachusetts.

Code of Federal Regulations, 2014 CFR

2014-07-01

... undue risk to environmental remediation efforts. Requests for waivers should be submitted in writing to... vessels or persons engaged in activities associated with remediation efforts in the New Bedford Harbor... advance notice of those activities by the U.S. Environmental Protection Agency (EPA). (c) Waivers. The...

33 CFR 165.125 - Regulated Navigation Area; EPA Superfund Site, New Bedford Harbor, Massachusetts.

Code of Federal Regulations, 2013 CFR

2013-07-01

... undue risk to environmental remediation efforts. Requests for waivers should be submitted in writing to... vessels or persons engaged in activities associated with remediation efforts in the New Bedford Harbor... advance notice of those activities by the U.S. Environmental Protection Agency (EPA). (c) Waivers. The...

33 CFR 165.125 - Regulated Navigation Area; EPA Superfund Site, New Bedford Harbor, Massachusetts.

Code of Federal Regulations, 2012 CFR

2012-07-01

... undue risk to environmental remediation efforts. Requests for waivers should be submitted in writing to... vessels or persons engaged in activities associated with remediation efforts in the New Bedford Harbor... advance notice of those activities by the U.S. Environmental Protection Agency (EPA). (c) Waivers. The...

76 FR 33273 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-08

... of Qualitative Feedback on Agency Service Delivery (New) AGENCY: Environmental Protection Agency (EPA... Qualitative Feedback on Agency Service Delivery (New). ICR numbers: EPA ICR Nos. 2434.01 and 2435.01, OMB... in 40 CFR part 9. Abstract: The information collection activity will garner qualitative customer and...

Evaluation of the antimicrobial properties of different parts of Citrus aurantifolia (lime fruit) as used locally.

PubMed

Aibinu, Ibukun; Adenipekun, Tayo; Adelowotan, Toyin; Ogunsanya, Tolu; Odugbemi, Tolu

2006-11-13

We investigated the potency of Citrus aurantifolia (Lime fruit), against pathogens, in the different forms in which this fruit plant is used locally (juice of the fruit, burnt rind of the fruit commonly known as "epa-ijebu" in the Yoruba dialect) and the oil obtained from steam distillation of the fruit. The antimicrobial activity of "epa-ijebu" in different solvents was also compared. The solvents include palm-wine (a local alcoholic drink tapped from palm trees), Seaman's Schnapps 40% alcoholic drink, water, ethanol and fermented water from 3 days soaked milled maize known as "ekan-ogi" or "omidun" in the Yoruba dialect. Antimicrobial activity was carried out by the agar well diffusion. The clinical isolates used included Anaerobic facultative bacteria, namely: Staphylococcus aureus ATCC 25213, Staphylococcus aureus, Salmonella paratyphi, Shigella flexnerii, Streptococcus faecalis, Citrobacter spp, Serratia spp, Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli ATCC 25922, and Escherichia coli; Fungi such as Aspergillus niger and Candida albicans; and Anaerobes which includes Bacteroides spp, Porphyromonas spp, and Clostridium spp. Crude extracts of all solvents used varied in zones of inhibition. The anaerobes and the gram-positive bacteria were susceptible to all the extracts with minimum inhibitory concentration (MIC) ranging from 32 mg/ml-128 g/ml. The activity against the fungi showed only the oil extract potent for A. niger, while Candida albicans was susceptible to all the extracts with MIC ranging from 256 mg/ml-512 mg/ml. The gram-negatives have MIC ranging from 64 mg/ml-512 mg/ml. Minimum bactericidal concentration (MBC) ranged between 32 mg/ml to 512 mg/ml depending on isolates and extracting solvent. The oil and palm-wine extract of "epa-ijebu" showed greater activity than the other extracts. The killing rate of the schnapps extract on S. aureus and E. coli was 1 and 3.5 hours respectively.

EPA's Draft 2017 Construction General Permit (CGP)

EPA Pesticide Factsheets

EPA is preparing to reissue the Construction General Permit (CGP). The general permit, issued under the Clean Water Act's National Pollutant Discharge Elimination System, authorizes stormwater discharges from construction activities.

Chemopreventive Effects of Dietary Eicosapentaenoic Acid Supplementation in Experimental Myeloid Leukemia.

PubMed

Finch, Emily R; Kudva, Avinash K; Quickel, Michael D; Goodfield, Laura L; Kennett, Mary J; Whelan, Jay; Paulson, Robert F; Prabhu, K Sandeep

2015-10-01

Current therapies for treatment of myeloid leukemia do not eliminate leukemia stem cells (LSC), leading to disease relapse. In this study, we supplemented mice with eicosapentaenoic acid (EPA, C20:5), a polyunsaturated omega-3 fatty acid, at pharmacologic levels, to examine whether the endogenous metabolite, cyclopentenone prostaglandin delta-12 PGJ3 (Δ(12)-PGJ3), was effective in targeting LSCs in experimental leukemia. EPA supplementation for 8 weeks resulted in enhanced endogenous production of Δ(12)-PGJ3 that was blocked by indomethacin, a cyclooxygenase (COX) inhibitor. Using a murine model of chronic myelogenous leukemia (CML) induced by bone marrow transplantation of BCR-ABL-expressing hematopoietic stem cells, mice supplemented with EPA showed a decrease in the LSC population, and reduced splenomegaly and leukocytosis, when compared with mice on an oleic acid diet. Supplementation of CML mice carrying the T315I mutation (in BCR-ABL) with EPA resulted in a similar effect. Indomethacin blocked the EPA effect and increased the severity of BCR-ABL-induced CML and decreased apoptosis. Δ(12)-PGJ3 rescued indomethacin-treated BCR-ABL mice and decreased LSCs. Inhibition of hematopoietic-prostaglandin D synthase (H-PGDS) by HQL-79 in EPA-supplemented CML mice also blocked the effect of EPA. In addition, EPA supplementation was effective in a murine model of acute myeloid leukemia. EPA-supplemented mice exhibited a decrease in leukemia burden and a decrease in the LSC colony-forming unit (LSC-CFU). The decrease in LSCs was confirmed through serial transplantation assays in all disease models. The results support a chemopreventive role for EPA in myeloid leukemia, which is dependent on the ability to efficiently convert EPA to endogenous COX-derived prostanoids, including Δ(12)-PGJ3. ©2015 American Association for Cancer Research.

Two-Stage Enzymatic Preparation of Eicosapentaenoic Acid (EPA) And Docosahexaenoic Acid (DHA) Enriched Fish Oil Triacylglycerols.

PubMed

Zhang, Zhen; Liu, Fang; Ma, Xiang; Huang, Huihua; Wang, Yong

2018-01-10

Fish oil products in the form of triacylglycerols generally have relatively low contents of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and so it is of potential research and industrial interest to enrich the related contents in commercial products. Thereby an economical and efficient two-stage preparation of EPA and DHA enriched fish oil triacylglycerols is proposed in this study. The first stage was the partial hydrolysis of fish oil by only 0.2 wt.‰ AY "Amano" 400SD which led to increases of EPA and DHA contents in acylglycerols from 19.30 and 13.09 wt % to 25.95 and 22.06 wt %, respectively. Subsequently, products of the first stage were subjected to transesterification with EPA and DHA enriched fatty acid ethyl esters (EDEE) as the second stage to afford EPA and DHA enriched fish oil triacylglycerols by using as low as 2 wt % Novozyme 435. EDEEs prepared from fish oil ethyl ester, and recycled DHA and EPA, respectively, were applied in this stage. Final products prepared with two different sources of EDEEs were composed of 97.62 and 95.92 wt % of triacylglycerols, respectively, with EPA and DHA contents of 28.20 and 21.41 wt % for the former and 25.61 and 17.40 wt % for the latter. Results not only demonstrate this two-stage process's capability and industrial value for enriching EPA and DHA in fish oil products, but also offer new opportunities for the development of fortified fish oil products.

EPA attenuates ultraviolet radiation-induced downregulation of aquaporin-3 in human keratinocytes.

PubMed

Jeon, Byoung-Kook; Kang, Moon-Kyung; Lee, Ghang-Tai; Lee, Kun-Kuk; Lee, Ho-Sub; Woo, Won-Hong; Mun, Yeun-Ja

2015-08-01

Eicosapentaenoic acid (EPA) is an omega-3 polyunsaturated fatty acid (ω-3 PUFA) that protects against photodamage and photocarcinogenesis in mammals. Aquaporin-3 (AQP3) is a water/glycerol transport protein that is found in basal layer keratinocytes. In this study, we have investigated the protective effect of EPA against ultraviolet B (UVB)-induced AQP3 downregulation in human keratinocytes. EPA treatment was found to increase AQP3 gene and protein expression in human epidermal keratinocytes (HaCaT). Using a specific inhibitor, we observed that the effect of EPA on AQP3 expression was mediated by extracellular signal-regulated kinase (ERK) activation. UVB radiation induced AQP3 downregulation in HaCaT cells, and it was found that EPA treatment attenuated UVB-induced AQP3 reduction and the associated cell death. UVB-induced downregulation of AQP3 was blocked by EPA and p38 inhibitor SB203580. Collectively, the present results show that EPA increased AQP3 expression and that this led to a reduction UVB-induced photodamage.

ENVIRONMENTAL TECHNOLOGY VERIFICATION: JOINT (NSF-EPA) VERIFICATION STATEMENT AND REPORT FOR TREATMENT OF WASTEWATER GENERATED DURING DECONTAMINATION ACTIVITIES - ULTRASTRIP SYSTEMS, INC., MOBILE EMERGENCY FILTRATION SYSTEM (MEFS) - 04/14/WQPC-HS

EPA Science Inventory

Performance verification testing of the UltraStrip Systems, Inc., Mobile Emergency Filtration System (MEFS) was conducted under EPA's Environmental Technology Verification (ETV) Program at the EPA Test and Evaluation (T&E) Facility in Cincinnati, Ohio, during November, 2003, thr...

75 FR 52734 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Cooling...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-27

... Facilities (Renewal), EPA ICR No. 2060.04, OMB Control No. 2040-0257 AGENCY: Environmental Protection Agency...: Cooling Water Intake Structure Phase II Existing Facilities (Renewal). ICR Numbers: EPA ICR No. 2060.04... (EPA ICR No. 2060.03) covers the last 2 years of the permit approval period (i.e., years 4 and 5 after...

75 FR 57941 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-23

... FURTHER INFORMATION CONTACT: Karen VanSickle, Clean Air Markets Division, Office of Air and Radiation... Docket Center (EPA/DC), EPA West, Room 3334, 1301 Constitution Ave., NW., Washington, DC. The EPA/DC Public Reading Room is open from 8:30 a.m. to 4:30 p.m., Monday through Friday, excluding legal holidays...

EPA Facility Registry Service (FRS): ICIS

EPA Pesticide Factsheets

This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link to the Integrated Compliance Information System (ICIS). When complete, ICIS will provide a database that will contain integrated enforcement and compliance information across most of EPA's programs. The vision for ICIS is to replace EPA's independent databases that contain enforcement data with a single repository for that information. Currently, ICIS contains all Federal Administrative and Judicial enforcement actions and a subset of the Permit Compliance System (PCS), which supports the National Pollutant Discharge Elimination System (NPDES). ICIS exchanges non-sensitive enforcement/compliance activities, non-sensitive formal enforcement actions and NPDES information with FRS. This web feature service contains the enforcement/compliance activities and formal enforcement action related facilities; the NPDES facilities are contained in the PCS_NPDES web feature service. FRS identifies and geospatially locates facilities, sites or places subject to environmental regulations or of environmental interest. Using vigorous verification and data management procedures, FRS integrates facility data from EPA's national program systems, other federal agencies, and State and tribal master facility records and provides EPA with a centrally managed, single source of comprehensive and authoritative information on f

EPA Community Activities

EPA Pesticide Factsheets

EPA supports community-based problem solving through grants and assistance to address health threats posed by a range of environmental hazards in San Joaquin Valley, including drinking water contamination and revitalization plans for downtown Fresno.

Quality Management Plan for EPA Region 1

EPA Pesticide Factsheets

The QMP describes policies, procedures & management systems within EPA NE that govern quality assurance & quality control activities supporting the transparency & scientific defensibility of environmental data collected, used & disseminated by the Region.

Essentials of PEM Fellowship Part 2: The Profession in Entrustable Professional Activities.

PubMed

Hsu, Deborah; Nypaver, Michele; Fein, Daniel M; McAneney, Constance; Santen, Sally; Nagler, Joshua; Zuckerbraun, Noel; Roskind, Cindy Ganis; Reynolds, Stacy; Zaveri, Pavan; Stankovic, Curt; House, Joseph B; Langhan, Melissa; Titus, M Olivia; Dahl-Grove, Deanna; Klasner, Ann E; Ramirez, Jose; Chang, Todd; Jacobs, Elizabeth; Chapman, Jennifer; Lumba-Brown, Angela; Thompson, Tonya; Mittiga, Matthew; Eldridge, Charles; Heffner, Viday; Herman, Bruce E; Kennedy, Christopher; Madhok, Manu; Kou, Maybelle

2016-06-01

This article is the second in a 7-part series that aims to comprehensively describe the current state and future directions of pediatric emergency medicine (PEM) fellowship training from the essential requirements to considerations for successfully administering and managing a program to the careers that may be anticipated upon program completion. This article describes the development of PEM entrustable professional activities (EPAs) and the relationship of these EPAs with existing taxonomies of assessment and learning within PEM fellowship. It summarizes the field in concepts that can be taught and assessed, packaging the PEM subspecialty into EPAs.

Cheminformatics Analysis of EPA ToxCast Chemical Libraries ...

EPA Pesticide Factsheets

An important goal of toxicology research is the development of robust methods that use in vitro and chemical structure information to predict in vivo toxicity endpoints. The US EPA ToxCast program is addressing this goal using ~600 in vitro assays to create bioactivity profiles on a set of 320 compounds, mostly pesticide actives, that have well characterized in vivo toxicity. These 320 compounds (EPA-320 set evaluated in Phase I of ToxCast) are a subset of a much larger set of ~10,000 candidates that are of interest to the EPA (called here EPA-10K). Predictive models of in vivo toxicity are being constructed from the in vitro assay data on the EPA-320 chemical set. These models require validation on additional chemicals prior to wide acceptance, and this will be carried out by evaluating compounds from EPA-10K in Phase II of ToxCast. We have used cheminformatics approaches including clustering, data visualization, and QSAR to develop models for EPA-320 that could help prioritizing EPA-10K validation chemicals. Both chemical descriptors, as well as calculated physicochemical properties have been used. Compounds from EPA-10K are prioritized based on their similarity to EPA-320 using different similarity metrics, with similarity thresholds defining the domain of applicability for the predictive models built for EPA-320 set. In addition, prioritized lists of compounds of increasing dissimilarity from the EPA-320 have been produced, to test the ability of the EPA-320

Long-chain n-3 PUFA in vegetarian women: a metabolic perspective.

PubMed

Burdge, Graham C; Tan, Sze-Yen; Henry, Christiani Jeyakumar

2017-01-01

Vegetarian diets have been associated with health benefits, but paradoxically are low in EPA and DHA which are important for development, particularly of the central nervous system, and for health. Humans have limited capacity for synthesis of EPA and DHA from α-linolenic acid, although this is greater in women than men. Oily fish and, to a lesser extent, dairy foods and meat are the primary sources of EPA and DHA in the diet. Exclusion of these foods from the diet by vegetarians is associated consistently with lower EPA and DHA status in vegetarian women compared with omnivores. The purpose of the present review was to assess the impact of low EPA and DHA status in vegetarian pregnancies on the development and health of children. EPA and DHA status was lower in breast milk and in infants of vegetarian mothers than those born to omnivore mothers, which suggests that in the absence of pre-formed dietary EPA and DHA, synthesis from α-linolenic acid is an important process in determining maternal EPA and DHA status in pregnancy. However, there have been no studies that have investigated the effect of low maternal DHA status in vegetarians on cognitive function in children. It is important to address this gap in knowledge in order to be confident that vegetarian and vegan diets during pregnancy are safe in the context of child development.

75 FR 6030 - EPA Science Advisory Board Staff Office Request for Nominations of Experts for the SAB Lead (Pb...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-05

... requesting public nominations of experts to form an SAB Ad Hoc Panel to review EPA's draft technical analyses... residential dust. OPPT is developing draft technical analyses that will be used to support: (a) Possible... that the SAB conduct a review of these draft technical analyses. The SAB was established by 42 U.S.C...

77 FR 29581 - Approval and Promulgation of Implementation Plans; Florida; Section 128 and 110(a)(2)(E)(ii) and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-18

... ID No. EPA-R04- OAR-2011-0809, by one of the following methods: 1. www.regulations.gov : Follow the... available on the Internet. If you submit an electronic comment, EPA recommends that you include your name... the Internet and will be publicly available only in hard copy form. Publicly available docket [[Page...

EPA at the National Science Teachers Association STEM Forum

EPA Pesticide Factsheets

EPA staff will be sharing educational resources, materials, information and STEM (Science, Technology, Engineering, and Mathematics) hands-on activities at the National Science Teachers Association's STEM Forum in Philadelphia, PA

Eicosapentaenoic Acid-Enriched Phosphatidylcholine Attenuated Hepatic Steatosis Through Regulation of Cholesterol Metabolism in Rats with Nonalcoholic Fatty Liver Disease.

PubMed

Liu, Yanjun; Shi, Di; Tian, Yingying; Liu, Yuntao; Zhan, Qiping; Xu, Jie; Wang, Jingfeng; Xue, Changhu

2017-02-01

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the world. Disturbed cholesterol metabolism plays a crucial role in the development of NAFLD. The present study was conducted to evaluate the effects of EPA-PC extracted from sea cucumber on liver steatosis and cholesterol metabolism in NAFLD. Male Wistar rats were randomly divided into seven groups (normal control group, model group, lovastatin group, low- and high-dose EPA groups, and low- and high-dose EPA-PC groups). Model rats were established by administering a diet containing 1% orotic acid. To determine the possible cholesterol metabolism promoting mechanism of EPA-PC, we analyzed the transcription of key genes and transcriptional factors involved in hepatic cholesterol metabolism. EPA-PC dramatically alleviated hepatic lipid accumulation, reduced the serum TC concentration, and elevated HDLC levels in NAFLD rats. Fecal neutral cholesterol excretion was also promoted by EPA-PC administration. Additionally, EPA-PC decreased the mRNA expression of hydroxymethyl glutaric acid acyl (HMGR) and cholesterol 7α-hydroxylase (CYP7A), and increased the transcription of sterol carrying protein 2 (SCP2). Moreover, EPA-PC stimulated the transcription of peroxisome proliferators-activated receptor α (PPARα) and adenosine monophosphate activated protein kinase (AMPK) as well as its modulators, liver kinase B1 (LKB1) and Ca 2+ /calmodulin-dependent kinase kinase (CAMKK). Based on the results, the promoting effects of EPA-PC on NAFLD may be partly associated with the suppression of cholesterol synthesis via HMGR inhibition and the enhancement of fecal cholesterol excretion through increased SCP2 transcription. The underlying mechanism may involve stimulation of PPARα and AMPK.

Potential benefits of eicosapentaenoic acid on atherosclerotic plaques.

PubMed

Nelson, J R; Wani, O; May, H T; Budoff, M

2017-04-01

Residual cardiovascular (CV) risk remains in some patients despite optimized statin therapy and may necessitate add-on therapy to reduce this risk. Eicosapentaenoic acid (EPA), an omega-3 polyunsaturated fatty acid, lowers plasma triglyceride levels without raising low-density lipoprotein cholesterol levels and has potential beneficial effects on atherosclerotic plaques. Animal studies have shown that EPA reduces levels of pro-inflammatory cytokines and chemokines. In clinical trials utilizing a wide spectrum of plaque imaging modalities, EPA has shown beneficial effects on plaque characteristics. Studies of patients with coronary artery disease receiving statin therapy suggest that EPA may decrease plaque vulnerability and prevent plaque progression. EPA also decreased pentraxin-3 and macrophage accumulation. A large, randomized, Japanese study reported that EPA plus a statin resulted in a 19% relative reduction in major coronary events at 5years versus a statin alone in patients with hypercholesterolemia (P=0.011). Icosapent ethyl, a high-purity prescription form of EPA ethyl ester, has been shown to reduce triglyceride levels and markers of atherosclerotic inflammation. Results of an ongoing CV outcomes study will further define the potential clinical benefits of icosapent ethyl in reducing CV risk in high-risk patients receiving statin therapy. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

76 FR 33274 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-08

... Activities; Submission to OMB for Review and Approval; Comment Request; NESHAP for Area Sources: Electric Arc... preferred method), or by e-mail to [email protected] , or by mail to: EPA Docket Center (EPA/DC..., 1200 Pennsylvania Avenue, NW., Washington, DC 20460, and (2) OMB at: Office of Information and...

77 FR 37901 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-25

... Activities; Submission to OMB for Review and Approval; Comment Request; NESHAP for Flexible Polyurethane Foam... Constitution Avenue NW., Washington, DC. The EPA Docket Center Public Reading Room is open from 8:30 a.m. to 4... Flexible Polyurethane Foam Fabrication (Renewal). ICR Numbers: EPA ICR Number 2027.05, OMB Control Number...

Other EPA Initiatives to Protect the Ozone Layer

EPA Pesticide Factsheets

Access information on EPA's efforts to address ozone layer depletion through voluntary partnerships with the private sector and activities aimed at educating the public about the health effects of ozone layer depletion.

Notification: Evaluate EPA’s Progress Under Plan EJ 2014

EPA Pesticide Factsheets

Project #OPE-FY14-0040, June 9, 2014. The U.S. Environmental Protection Agency's (EPA's) Office of Inspector General (OIG) is starting preliminary research on the EPA's oversight of environmental justice activities.

75 FR 39244 - Agency Information Collection Activities OMB Responses

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-08

.... EPA ICR Number 2098.05; NESHAP for Primary Magnesium Refining; 40 CFR part 63, subparts A and TTTTT.... EPA ICR Number 1666.08; NESHAP for Commercial Ethylene Oxide Sterilization and Fumigation Operations...

EPA New England Environmental Data Review Supplement

EPA Pesticide Factsheets

This document provides Region 1-specific implementation guidance for reviewing and reporting sample results generated for data collection activities and is used in conjunction with the EPA New England Environmental Data Review Program Guidance.

Supporting Priority State Activities in the Bay Delta

EPA Pesticide Factsheets

EPA written comments on the Bay Delta Strategic Workplan and EPA comments at SWRCB March 19, 2008 public workshop on development of San Francisco Bay/Sacramento-San Joaquin River Delta Strategic Workplan.

Stimulation of glycerol kinase in grass carp preadipocytes by EPA.

PubMed

Lei, Caixia; Tian, Jingjing; Ji, Hong

2017-06-01

This study was conducted to assess the effect of eicosapentaenoic acid (EPA) on grass carp preadipocyte glycerol kinase (GyK) expression, as well as to explore the mechanism. Here, we cloned partial sequence of grass carp GyK gene and analyzed its tissue distribution. The result showed that GyK gene expressed most in the liver, followed by adipose tissue and the kidney. Besides, 400 μM oleic acid (18:1n-9, OA) was used to establish a hypertrophic preadipocyte model. GyK gene expression and enzyme activity were significantly enhanced after model cells were treated with 100 μM eicosapentaenoic acid (20:5n-3, EPA) for 6, 12, and 24 h. Meanwhile, peroxisome proliferative-activated receptor (PPAR)γ, adipose triglyceride lipase (ATGL), and the two isoforms of grass carp HSL gene were first identified by Sun et al (2016), and they defined the two isoforms as HSLa and HSLb. Therefore, maybe HSLa and HSLb are appropriate.. The content of triglyceride was dramatically increased by EPA treatment for 24 h. Further, a competitive ATGL antagonist, HY-15859, attenuated the increase in GyK induced by EPA at 12 h. Surprisingly, the enhanced lipolysis and PPARγ gene expression induced by serum deprivation were paralleled by an increase in GyK gene expression, whereas a stabilization in GyK enzyme activity. Other fatty acids, including docosahexaenoic acid, alpha-linolenic acid, linoleic acid, and OA also promoted GyK gene expression. Moreover, an irreversible PPARγ antagonist, GW9662, was used to investigate the role of PPARγ in GyK induction. Data showed that GW9662 abolished the induction of GyK by EPA at 12 h. Together, these data suggested that EPA elevated grass carp preadipocytes GyK expression. ATGL and PPARγ contributed to the induction of GyK. PPARγ may be a key regulator in response to GyK expression induced by EPA.

Exogenous modification of platelet membranes with the omega-3 fatty acids EPA and DHA reduces platelet procoagulant activity and thrombus formation.

PubMed

Larson, Mark K; Tormoen, Garth W; Weaver, Lucinda J; Luepke, Kristen J; Patel, Ishan A; Hjelmen, Carl E; Ensz, Nicole M; McComas, Leah S; McCarty, Owen J T

2013-02-01

Several studies have implicated the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in inhibition of normal platelet function, suggesting a role for platelets in EPA- and DHA-mediated cardioprotection. However, it is unclear whether the cardioprotective mechanisms arise from alterations to platelet-platelet, platelet-matrix, or platelet-coagulation factor interactions. Our previous results led us to hypothesize that EPA and DHA alter the ability of platelets to catalyze the generation of thrombin. We tested this hypothesis by exogenously modifying platelet membranes with EPA and DHA, which resulted in compositional changes analogous to increased dietary EPA and DHA intake. Platelets treated with EPA and DHA showed reductions in the rate of thrombin generation and exposure of platelet phosphatidylserine. In addition, treatment of platelets with EPA and DHA decreased thrombus formation and altered the processing of thrombin precursor proteins. Furthermore, treatment of whole blood with EPA and DHA resulted in increased occlusion time and a sharply reduced accumulation of fibrin under flow conditions. These results demonstrate that EPA and DHA inhibit, but do not eliminate, the ability of platelets to catalyze thrombin generation in vitro. The ability of EPA and DHA to reduce the procoagulant function of platelets provides a possible mechanism behind the cardioprotective phenotype in individuals consuming high levels of EPA and DHA.

EPA Enviropod. A summary of the use of the Enviropod under a Memorandum of Understanding among EPA Region 8, the State of Utah, and the University of Utah Research Institute

NASA Technical Reports Server (NTRS)

Ridd, M. K.

1984-01-01

Twenty-three missions were flown using the EPA's panoramic camera to obtain color and color infrared photographs of landslide and flood damage in Utah. From the state's point of view, there were many successes. The biggest single obstacle to smooth and continued performance was unavailable aircraft. The Memorandum of Understanding between the State of Utah, the Environmental Protection Agency, and the Center for Remote Sensing and Cartography is included along with forms for planning enviropod missions, for requesting flights, and for obtaining feedback from participating agencies.

Report: Management of Overtime Improved at EPA’s Immediate Office of Air and Radiation

EPA Pesticide Factsheets

Report #16-P-0111, March 24, 2016. An OAR employee may have incurred unnecessary overtime costs, and incurred improper administrative leave charges, Request for Overtime Authorization forms (EPA Form 2560-7)

75 FR 30812 - Agency Information Collection Activities: Request for Comments on Thirty-One Proposed Information...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-02

... 264, Subpart CC and 40 CFR Part 265). ICR Numbers: EPA ICR Number 1593.08, OMB Control Number 2060... ICR Number 1593.08, OMB Control Number 2060-0318; expiration date October 31, 2010. (6) NESHAP for..., subpart CC and 40 CFR part 265), Docket ID Number: EPA-HQ-OECA-2010-0370, EPA ICR Number 1593.08, OMB...

78 FR 66916 - Alaskan Seafood Processing Effluent Limitations Guidelines

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-07

... discharges which EPA is considering whether to promulgate in final form. DATES: Comments on this Notice, as... consider your comment. Electronic files should avoid the use of special characters, any form of encryption... data took the form of a questionnaire that included the following topics: general information about the...

SINKEX 2014- Determination and Agreement between Navy and EPA

EPA Pesticide Factsheets

EPA determined that the activity authorized under the ocean dumping general permit for the SINKEX program conducted by Navy does not pose an unreasonable risk of injury to human health or the environment.

75 FR 42438 - Agency Information Collection Activities; Proposed Collection; Comment Request; Willingness To...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-21

... Facilities Cooling Water Intake Structures: Instrument, Pre-test, and Implementation (New). ICR numbers: EPA... test for and ameliorate survey non-response bias. EPA will follow standard practice in stated...

National Tribal Air Association Operations Grant - Closed Announcement FY 2013

EPA Pesticide Factsheets

EPA cooperative agreement to strengthen tribal air programs in order to enhance communication and coordination on policy and regulatory activities between federally recognized tribes, EPA, and Indian tribes and Alaska Native Villages.

Regulatory basis for the Waste Isolation Pilot Plant performance assessment

DOE Office of Scientific and Technical Information (OSTI.GOV)

HOWARD,BRYAN A.; CRAWFORD,M.B.; GALSON,D.A.

2000-05-22

The Waste Isolation Pilot Plant (WIPP) is the first operational repository designed for the safe disposal of transuranic (TRU) radioactive waste from the defense programs of the US Department of Energy (DOE). The US Environmental Protection Agency (EPA) is responsible for certifications and regulation of the WIPP facility for the radioactive components of the waste. The EPA has promulgated general radioactive waste disposal standards at 40 CFR Part 191. and WIPP-specific criteria to implement and interpret the generic disposal standards at 40 CFR Part 194. In October 1996. the DOE submitted its Compliance Certification Application (CCA) to the EPA tomore » demonstrate compliance with the disposal standards at Subparts B and C of 40 CFR Part 191. This paper summarizes the development of the overall legal framework for radioactive waste disposal at the WIPP, the parallel development of the WIPP performance assessment (PA), and how the EPA disposal standards and implementing criteria formed the basis for the CCA WIPP PA. The CCA resulted in a certification in May 1998 by the EPA of the WIPP'S compliance with the EPA's disposal standard, thus enabling the WIPP to begin radioactive waste disposal.« less

Meet EPA Chemical Engineer Deborah Luecken

EPA Pesticide Factsheets

Deborah Luecken is a research scientist who develops descriptions of the chemistry that occurs in the atmosphere to form ozone and other air pollutants. She works with a group developing a computer model that can predict how air pollution is formed

EPCRA Instructions to the Tier II Emergency and Hazardous Chemical Inventory Form

EPA Pesticide Factsheets

The form is required for Tier Two reporting of hazardous chemicals in quantities equal to or greater than established threshold amounts. Sections include chemical description, hazard categories from both EPA and OSHA, and storage details.

Temporary Authorization Form for Personally Owned Equipment

EPA Pesticide Factsheets

All visitors bringing a personal laptop into EPA-RTP’s facilities must complete a “Temporary Authorization for Personally Owned Equipment” form and submit it to campus security upon their departure (last day of visit if more than one day).

40 CFR 60.2795 - In what form can I submit my reports?

Code of Federal Regulations, 2011 CFR

2011-07-01

... using the Electronic Reporting Tool (ERT) (see http://www.epa.gov/ttn/chief/ert/ert_tool.html). ... or Before November 30, 1999 Model Rule-Recordkeeping and Reporting § 60.2795 In what form can I...

EPA's Report on the Environment (Roe) (2008 Final Report) ...

EPA Pesticide Factsheets

EPA released the final report, EPA's 2008 Report on the Environment (EPA 2008 ROE), a science-based report that answers questions about recent trends in human health and the environment. This report aids the American people with an important resource from which they can better understand trends in the condition of the air, water, land, and human health of the United States. This report uses scientifically sound measures, called indicators, to address fundamental questions relevant to the EPA's mission to protect the environment and human health. To accomplish its mission to protect human health and the environment, EPA must pay close attention to trends in the condition of the Nation's environment. This kind of information, which is captured in EPA's 2008 ROE, can help EPA to prioritize its work and to focus on human health and ecological activities that can lead to improvements in the conditions of the Nation's environment. The purpose of EPA’s ROE 2007 is to compile the most reliable indicators currently available that help answer a series of questions about trends in the environment and human health that EPA believes are of critical importance to its mission and to the national interest.

75 FR 43970 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-27

....07, OMB Control Number 2060-0327 AGENCY: Environmental Protection Agency (EPA). ACTION: Notice... Anodizing Tanks (Renewal). ICR Numbers: EPA ICR Number 1611.07, OMB Control Number 2060-0327. ICR Status...

75 FR 64722 - Agency Information Collection Activities; Proposed Collection; Comment Request; Application...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-20

... Control No. 2060-0264 AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: In... Tribal Agencies. ICR numbers: EPA ICR No. 1643.07, OMB Control No. 2060-0264. ICR status: This ICR is...

75 FR 8333 - Agency Information Collection Activities: Proposed Collection; Comment Request; Compliance...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-24

....07, OMB Control No. 2060-0376 AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY...). ICR numbers: EPA ICR No. 1663.07, OMB Control No.: 2060-0376. ICR status: This ICR is currently...

EPA'S TOXICOGENOMICS PARTNERSHIPS ACROSS GOVERNMENT, ACADEMIA AND INDUSTRY

EPA Science Inventory

Genomics, proteomics and metabonomics technologies are transforming the science of toxicology, and concurrent advances in computing and informatics are providing management and analysis solutions for this onslaught of toxicogenomic data. EPA has been actively developing an intra...

75 FR 19383 - Agency Information Collection Activities: Proposed Collection; Comment Request; State Review...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-14

... No. 2020-0031 AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: In compliance.... ICR numbers: EPA ICR No. 2185.04, OMB Control No. 2020-0031. ICR status: This ICR is currently...

Citizen Science Air Monitoring in the Ironbound Community

EPA Science Inventory

The Environmental Protection Agency’s (EPA) mission is to protect human health and the environment. To move toward achieving this goal, EPA is facilitating identification of potential environmental concerns, particularly in vulnerable communities. This includes actively supportin...

MyEnviroMapper

EPA Pesticide Factsheets

EnviroMapper for Envirofacts is a single point of access to select U.S. EPA environmental data. This Web site provides access to several EPA databases to provide you with information about environmental activities that may affect air, water, and l

Effects of eicosapentaenoic acid on hepatic dyslipidemia and oxidative stress in high fat diet-induced steatosis.

PubMed

Hirotani, Yoshihiko; Ozaki, Nozomi; Tsuji, Yoshihiro; Urashima, Yoko; Myotoku, Michiaki

2015-01-01

We investigated the ability of eicosapentaenoic acid (EPA) to prevent high-fat diet (HFD)-induced obesity and non-alcoholic fatty liver disease (NAFLD). Male C57BL/6J mice were fed standard chow (5.3% fat content), an HFD (32.0% fat content) or an HFD + EPA (1 g/kg/day EPA for the last 6 weeks) for 12 weeks. Serum total cholesterol, hepatic triglyceride and total cholesterol levels were significantly increased in the HFD group, in comparison with those of normal mice (p < 0.01). In contrast, hepatic triglyceride and total cholesterol levels were significantly decreased in the HFD + EPA group, in comparison with those of the HFD group (p < 0.05). In addition, EPA decreased the body weight of obese mice and improved hepatic function. Hepatic superoxide dismutase activity and glutathione levels were significantly decreased in obese mice, but increased with EPA administration. Our data suggest that EPA supplementation has a beneficial effect on NAFLD progression.

Milestones and entrustable professional activities: The key to practically translating competencies for interprofessional education?

PubMed

Wagner, Susan J; Reeves, Scott

2015-01-01

Competency-based education and practice have become foundational for developing interprofessional education (IPE) and interprofessional collaboration. There has been a plethora of competencies developed in these areas recently, both at individual institutions and nationally; however, their effective integration and thus potential has not been fully realized educationally. Milestones and entrustable professional activities (EPAs) are new concepts and assessment approaches from medical education that provide a way to functionally use and maximize competencies to ensure that competency is attained. They are applicable to learning activities both within the classroom and the clinic, as well as to lifelong learning. This paper defines and describes milestones and EPAs, considers the importance of their application to IPE, and summarizes a future research project that will identify EPAs for an IPE curriculum.

Effect of n-3 PUFA supplementation at different EPA:DHA ratios on the spontaneously hypertensive obese rat model of the metabolic syndrome.

PubMed

Molinar-Toribio, Eunice; Pérez-Jiménez, Jara; Ramos-Romero, Sara; Romeu, Marta; Giralt, Montserrat; Taltavull, Núria; Muñoz-Cortes, Mònica; Jáuregui, Olga; Méndez, Lucía; Medina, Isabel; Torres, Josep Lluís

2015-03-28

The increasing incidence of the metabolic syndrome (MetS), a combination of risk factors before the onset of CVD and type 2 diabetes, encourages studies on the role of functional food components such as long-chain n-3 PUFA as preventive agents. In the present study, we explore the effect of EPA and DHA supplementation in different proportions on spontaneously hypertensive obese (SHROB) rats, a model for the MetS in a prediabetic state with mild oxidative stress. SHROB rats were randomised into four groups (n 7), each supplemented with EPA/DHA at ratios of 1:1, 2:1 and 1:2, or soyabean oil as the control for 13 weeks. The results showed that in all the proportions tested, EPA/DHA supplementation significantly lowered total and LDL-cholesterol concentrations, compared with those of the control group. EPA/DHA supplementation at the ratios of 1:1 and 2:1 significantly decreased inflammation (C-reactive protein levels) and lowered oxidative stress (decreased excretion of urinary isoprostanes), mainly at the ratio of 1:2. The activity of antioxidant enzymes increased in erythrocytes, abdominal fat and kidneys, with magnitudes depending on the EPA:DHA ratio. PUFA mixtures from fish affected different MetS markers of CVD risk factors in SHROB rats, depending on the ratios of EPA/DHA supplementation. The activation of endogenous defence systems may be related to the reduction of inflammation and oxidative stress.

Mapping the Demand for Serious Games in Postgraduate Medical Education Using the Entrustable Professional Activities Framework.

PubMed

Graafland, Maurits; Ten Cate, Olle; van Seventer, Jan-Pieter; Schraagen, Jan Maarten C; Schijven, Marlies P

2015-10-01

Serious games are potentially powerful tools for residency training and increasingly attract attention from medical educators. At present, serious games have little evidence-based relations with competency-based medical education, which may impede their incorporation into residency training programs. The aim of this study was to identify highly valued entrustable professional activities (EPAs) to support designers in the development of new, serious games built on a valid needs-assessment. All 149 licensed medical specialists from seven specialties in one academic hospital participated in seven different Delphi expert panels. They filled out a two-round Delphi survey, aimed at identifying the most valuable EPAs in their respective curricula. Specialists were asked to name the most highly valued EPA in their area in the first Delphi round. In the second round, the generated responses were presented and ranked according to priority by the medical specialists. Sixty-two EPAs were identified as valuable training subjects throughout five specialties. Eleven EPAs--"management of trauma patient," "chest tube placement," "laparoscopic cholecystectomy," "assessment of vital signs," "airway management," "induction of general anesthesia," "assessment of suicidal patient," "psychiatric assessment," "gastroscopy," "colonoscopy," and "resuscitation of emergency patients"--were consistently given a high score. The future medical specialist is an active learner, comfortable with digital techniques and learning strategies such as serious gaming. In order to maximize the impact and acceptance of new serious games, it is vital to select the most relevant training subjects. Although some serious games have already targeted top-priority EPAs, plenty of opportunities remain.

Auto Emission Testing

NASA Technical Reports Server (NTRS)

1979-01-01

The photos show automobile engines being tested for nitrous oxide emissions, as required by the Environmental Protection Agency (EPA), at the Research and Engineering Division of Ford Motor Company, Dearborn. Michigan. NASA technical information helped the company develop a means of calculating emissions test results. Nitrous oxide emission readings vary with relative humidity in the test facility. EPA uses a standard humidity measurement, but the agency allows manufacturers to test under different humidity conditions, then apply a correction factor to adjust the results to the EPA standard. NASA's Dryden Flight Research Center developed analytic equations which provide a simple, computer-programmable method of correcting for humidity variations. A Ford engineer read a NASA Tech Brief describing the Dryden development and requested more detailed information in the form of a technical support package, which NASA routinely supplies to industry on request. Ford's Emissions Test Laboratory now uses the Dryden equations for humidity-adjusted emissions data reported to EPA.

Frequent Questions about the Manifest Registry

EPA Pesticide Factsheets

FAQs Including Can I submit multiple form samples to the EPA Registry for approval? Must I submit a continuation sheet sample to the Manifest Registry under section 262.21(d)? Can I typeset the form after I am approved to print the manifest?

40 CFR 60.2795 - In what form can I submit my reports?

Code of Federal Regulations, 2012 CFR

2012-07-01

... (CDX) by using the Electronic Reporting Tool (ERT) (see http://www.epa.gov/ttn/chief/ert/ert_tool.html). ... Reporting § 60.2795 In what form can I submit my reports? Submit initial, annual, and deviation reports...

A Transgenic Camelina sativa Seed Oil Effectively Replaces Fish Oil as a Dietary Source of Eicosapentaenoic Acid in Mice123

PubMed Central

Tejera, Noemi; Vauzour, David; Betancor, Monica B; Sayanova, Olga; Usher, Sarah; Cochard, Marianne; Rigby, Neil; Ruiz-Lopez, Noemi; Menoyo, David; Tocher, Douglas R; Napier, Johnathan A; Minihane, Anne Marie

2016-01-01

Background: Fish currently supplies only 40% of the eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) required to allow all individuals globally to meet the minimum intake recommendation of 500 mg/d. Therefore, alternative sustainable sources are needed. Objective: The main objective was to investigate the ability of genetically engineered Camelina sativa (20% EPA) oil (CO) to enrich tissue EPA and DHA relative to an EPA-rich fish oil (FO) in mammals. Methods: Six-week-old male C57BL/6J mice were fed for 10 wk either a palm oil–containing control (C) diet or diets supplemented with EPA-CO or FO, with the C, low-EPA CO (COL), high-EPA CO (COH), low-EPA FO (FOL), and high-EPA FO (FOH) diets providing 0, 0.4, 3.4, 0.3, and 2.9 g EPA/kg diet, respectively. Liver, muscle, and brain were collected for fatty acid analysis, and blood glucose and serum lipids were quantified. The expression of selected hepatic genes involved in EPA and DHA biosynthesis and in modulating their cellular impact was determined. Results: The oils were well tolerated, with significantly greater weight gain in the COH and FOH groups relative to the C group (P < 0.001). Significantly lower (36–38%) blood glucose concentrations were evident in the FOH and COH mice relative to C mice (P < 0.01). Hepatic EPA concentrations were higher in all EPA groups relative to the C group (P < 0.001), with concentrations of 0.0, 0.4, 2.9, 0.2, and 3.6 g/100 g liver total lipids in the C, COL, COH, FOL, and FOH groups, respectively. Comparable dose-independent enrichments of liver DHA were observed in mice fed CO and FO diets (P < 0.001). Relative to the C group, lower fatty acid desaturase 1 (Fads1) expression (P < 0.005) was observed in the COH and FOH groups. Higher fatty acid desaturase 2 (Fads2), peroxisome proliferator–activated receptor α (Ppara), and peroxisome proliferator–activated receptor γ (Pparg) (P < 0.005) expressions were induced by CO. No impact of treatment on liver X receptor α (Lxra) or sterol regulatory element-binding protein 1c (Srebp1c) was evident. Conclusions: Oil from transgenic Camelina is a bioavailable source of EPA in mice. These data provide support for the future assessment of this oil in a human feeding trial. PMID:26791554

Divergent shifts in lipid mediator profile following supplementation with n-3 docosapentaenoic acid and eicosapentaenoic acid.

PubMed

Markworth, James F; Kaur, Gunveen; Miller, Eliza G; Larsen, Amy E; Sinclair, Andrew J; Maddipati, Krishna Rao; Cameron-Smith, David

2016-11-01

In contrast to the well-characterized effects of specialized proresolving lipid mediators (SPMs) derived from eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), little is known about the metabolic fate of the intermediary long-chain (LC) n-3 polyunsaturated fatty acid (PUFA) docosapentaenoic acid (DPA). In this double blind crossover study, shifts in circulating levels of n-3 and n-6 PUFA-derived bioactive lipid mediators were quantified by an unbiased liquid chromatography-tandem mass spectrometry lipidomic approach. Plasma was obtained from human subjects before and after 7 d of supplementation with pure n-3 DPA, n-3 EPA or placebo (olive oil). DPA supplementation increased the SPM resolvin D5 n -3DPA (RvD5 n -3DPA ) and maresin (MaR)-1, the DHA vicinal diol 19,20-dihydroxy-DPA and n-6 PUFA derived 15-keto-PG E 2 (15-keto-PGE 2 ). EPA supplementation had no effect on any plasma DPA or DHA derived mediators, but markedly elevated monohydroxy-eicosapentaenoic acids (HEPEs), including the e-series resolvin (RvE) precursor 18-HEPE; effects not observed with DPA supplementation. These data show that dietary n-3 DPA and EPA have highly divergent effects on human lipid mediator profile, with no overlap in PUFA metabolites formed. The recently uncovered biologic activity of n-3 DPA docosanoids and their marked modulation by dietary DPA intake reveals a unique and specific role of n-3 DPA in human physiology.-Markworth, J. F., Kaur, G., Miller, E. G., Larsen, A. E., Sinclair, A. J., Maddipati, K. R., Cameron-Smith, D. Divergent shifts in lipid mediator profile following supplementation with n-3 docosapentaenoic acid and eicosapentaenoic acid. © FASEB.

Icosapent ethyl: Eicosapentaenoic acid concentration and triglyceride-lowering effects across clinical studies.

PubMed

Bays, Harold E; Ballantyne, Christie M; Doyle, Ralph T; Juliano, Rebecca A; Philip, Sephy

2016-09-01

Icosapent ethyl is a high-purity prescription form of eicosapentaenoic acid (EPA) ethyl ester approved at a dose of 4g/day as an adjunct to diet to reduce triglyceride (TG) levels in adult patients with severe (≥500mg/dL) hypertriglyceridemia. This post-hoc exploratory analysis examined the relationship of icosapent ethyl dose with EPA concentrations in plasma and red blood cells (RBCs) across 3 clinical studies-a phase 1 pharmacokinetic study in healthy adult volunteers and 2 pivotal phase 3 studies (MARINE and ANCHOR) in adult patients with hypertriglyceridemia-and examined the relationship between EPA levels and TG-lowering effects in MARINE and ANCHOR. In all 3 studies, icosapent ethyl produced dose-dependent increases in the concentrations of EPA in plasma and RBCs. In both MARINE and ANCHOR, these dose-dependent EPA increases correlated with the degree of TG level lowering (all P<0.01). In patients with high TG levels (≥200mg/dL) and treated with icosapent ethyl 4g/day, the end-of-treatment plasma and RBC EPA concentrations were >170μg/mL and>70μg/mL, respectively. These studies support icosapent ethyl as producing predictable dose-dependent pharmacokinetics/pharmacodynamics, with TG level lowering dependent upon icosapent ethyl dose and EPA concentrations in plasma and RBCs. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

ENVIRONMENTAL SAMPLING AND ANALYSIS IN THE AFTERMATH OF HURRICANE KATRINA

EPA Science Inventory

This presentation describes the environmental sampling completed by EPA in southeastern Louisiana after Hurricane Katrina caused major catastrophic damage. Presentation also describes EPA's Environmental Unit activities in Baton Rouge and New Orleans, LA, and Dallas, TX.

78 FR 68053 - Agency Information Collection Activities OMB Responses

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-13

... Effects Abroad of EPA Actions (Renewal); 40 CFR 6.301; was approved on 10/18/ 2013; OMB Number 2020-0033...- 0095; expires on 10/31/2016; Approved without change. Comment Filed EPA ICR Number 2300.12; Greenhouse...

National Enforcement Initiative: Keeping Industrial Pollutants Out of the Nation’s Waters

EPA Pesticide Factsheets

This page describes EPA's enforcement activities on water pollution from raw sewage and contaminated stormwater. This is one of EPA's National Enforcement Initiatives. Both enforcement cases, and a map of enforcement actions are provided.

Special Appropriation Act Projects

EPA Pesticide Factsheets

EPA is sometimes directed to provide funding to a specific entity for study, purpose, or activity.This information will be of interest to a community or other entity that has been identified in one of EPA's appropriations acts to receive such funding.

Managing the Quality of Environmental Data in EPA Region 9

EPA Pesticide Factsheets

EPA Pacific Southwest, Region 9's Quality Assurance (QA) section's primary mission is to effectively oversee and carry out the Quality System and Quality Management Plan, and project-level quality assurance and quality control (QA/QC) activities.

Report: EPA Needs to Reexamine How It Defines Its Payment Recapture Audit Program

EPA Pesticide Factsheets

Report #11-P-0362, July 19, 2011. EPA makes numerous efforts to recapture improper payments, but does not consider its activities to be a formal payment recapture audit program, as defined by OMB guidance.

Insights from the Development of HiveScience

EPA Science Inventory

The National Advisory Council for Environmental Policy and Technology (NACEPT) recently assessed EPA's approach to citizen science. The Council concluded that integration of citizen science into EPA's structure will accelerate virtually every Agency activity. HiveScience is a n...

75 FR 29752 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-27

... Surface Coating (Renewal), EPA ICR Number 2079.04, OMB Control Number 2060-0541 AGENCY: Environmental... Manufacturing Surface Coating (Renewal). ICR Numbers: EPA ICR Number 2079.04, OMB Control Number 2060-0541. ICR...

75 FR 22776 - Agency Information Collection Activities; Proposed Collection; Comment Request; Engine Emission...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-30

... Emission Recall Reports; EPA ICR No. 0282.15, OMB Control No. 2060-0048 AGENCY: Environmental Protection... Recall Reports (Renewal). ICR numbers: EPA ICR No. 0282.15, OMB Control No. 2060-0048. ICR status: This...

75 FR 76980 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-10

... ICR Number 0193.10, OMB Control Number 2060-0092 AGENCY: Environmental Protection Agency (EPA). ACTION... . Title: NESHAP for Beryllium (Renewal). ICR Numbers: EPA ICR Number 0193.10, OMB Control Number 2060-0092...

76 FR 3627 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-20

... (Renewal), EPA ICR Number 1643.07, OMB Control Number 2060-0264 AGENCY: Environmental Protection Agency..., Local, and Tribal Agencies (Renewal). ICR Numbers: EPA ICR Number 1643.07, OMB Control Number 2060-0264...

75 FR 25854 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-10

... 2060-0451 AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: In compliance with... Numbers: EPA ICR Number 1927.05, OMB Control Number 2060-0451. ICR Status: This ICR is scheduled to expire...

75 FR 2537 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-15

... Nonferrous Metals--Zinc, Cadmium, and Beryllium (Renewal); EPA ICR Number 2240.03, OMB Control Number 2060...--Zinc, Cadmium, and Beryllium (Renewal). ICR Numbers: EPA ICR Number 2240.03, OMB Control Number 2060...

75 FR 17915 - Agency Information Collection Activities; Proposed Collection; Comment Request; 8-Hour Ozone...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-08

... No. 2236.03, OMB Control No. 2060-0594 AGENCY: Environmental Protection Agency (EPA). ACTION: Notice... Standard Implementation Rule. ICR numbers: EPA ICR No. 2236.03, OMB Control No. 2060-0594. ICR status: This...

75 FR 5787 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-04

... (Renewal), EPA ICR Number 2098.05, OMB Control Number 2060- 0536 AGENCY: Environmental Protection Agency... Magnesium Refining (Renewal). ICR Numbers: EPA ICR Number 2098.05, OMB Control Number 2060-0536. ICR Status...

75 FR 35792 - Agency Information Collection Activities: Proposed Collection; Comment Request; Information...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-23

... Risk and Technology Review; EPA ICR No. 2393.01, OMB Control Number 2060-NEW AGENCY: Environmental...) Residual Risk and Technology Review (RTR). ICR numbers: EPA ICR Number 2393.01, OMB Control Number 2060-NEW...

Meet EPA Ecologist Caroline Ridley, Ph.D.

EPA Pesticide Factsheets

EPA ecologist Caroline Ridley assesses the impact of human activities on the environment.Her recent work includes examining the impacts of mining on salmon in Alaska and the impacts of hydraulic fracturing for oil and gas on drinking water nationwide.

Considering Traditional Ecological Knowledge (TEK) During the Cleanup Process

EPA Pesticide Factsheets

This memorandum provides direction to improve the decision-making process as it relates to site assessment, characterization, and cleanup activities, to ensure EPA's Office of Land and Emergency Management is considering TEK when tribes provide it to EPA.

75 FR 71695 - Pesticide Products; Registration Applications

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-24

...; Registration Applications AGENCY: Environmental Protection Agency ACTION: Notice. SUMMARY: EPA has received applications to register new uses for pesticide products containing previously registered active ingredients... (FIFRA), EPA is hereby providing notice of receipt and opportunity to comment on these applications...

Children’s Environmental Health 2005 - A Summary of EPA Activities

EPA Pesticide Factsheets

Children may not be sufficiently protected by regulatory standards set based on risks to adults. EPA has forged partnerships and taken steps to protect children's health from contaminants and pollutants in air, drinking water, and food.

REPORTING OF SELECTED EPA-SPONSORED FORM EIA-767 DATA FOR 1985-1987

EPA Science Inventory

The report is a compilation of 1985-87 data based on the Energy Information Administration's (ElA's) Form 767, "Steam-Electric Plant Operation and Design Report," an annual data collection form whose major output to date has been an annual data tape which is released to the publi...

OFFICE OF RESEARCH AND DEVELOPMENT'S FOUR LAB STUDY: TOXICOLOGICCAL AND CHEMICAL EVALUATION OF COMPLEX MIXTURES OF DISINFECTION BY-PRODUCTS (DBPS) AND QUALITY ASSURANCE ACTIVITIES FOR A LARGE U. S. EPA MULTILABORATORY STUDY

EPA Science Inventory

Office of Research and Development's Four Lab Study: Toxicological and Chemical Evaluation of Complex Mixtures of Disinfection By-Products (DBPs), and Quality Assurance Activities for a Large U.S. EPA Multilaboratoty Study

Thomas J. Hughes, Project and QA Manager, Expe...

Comparative study of the effects of phosphatidylcholine rich in DHA and EPA on Alzheimer's disease and the possible mechanisms in CHO-APP/PS1 cells and SAMP8 mice.

PubMed

Che, Hongxia; Zhou, Miaomiao; Zhang, Tiantian; Zhang, Lingyu; Ding, Lin; Yanagita, Teruyoshi; Xu, Jie; Xue, Changhu; Wang, Yuming

2018-01-24

Metabolic stress induced by a high-fat (HF) diet leads to cognitive dysfunction and aging. In the present study, Chinese hamster ovary cells stably transfected with amyloid precursor protein (APP) and presenilin 1 (PS1) (CHO-APP/PS1 cells) and SAMP8 mice fed with an HF diet were used to study the effects of docosahexaenoic acid (DHA)-enriched phosphatidylcholine (DHA-PC) and eicosapentaenoic acid (EPA)-enriched phosphatidylcholine (EPA-PC) on Alzheimer's disease (AD) and the possible mechanisms involved in these effects. Behavior test results indicated that DHA-PC exerted better effects than EPA-PC on improving memory and cognitive deficiency. Further analysis showed that DHA-PC and EPA-PC could significantly decrease β-amyloid (Aβ) concentrations in CHO-APP/PS1 cells and SAMP8 mice by inhibiting APP, PS1, and BACE1 expression. Moreover, both DHA-PC and EPA-PC can increase the activities of the antioxidant index, including SOD, T-AOC, GSH, and GSH-PX, and inhibit levels of MDA, NO, and NOS. In addition, the expressions of inflammatory factors (TNF-α, IL-1β) and apoptosis were significantly suppressed via improving the ratio of Bcl-2/Bax and decreasing the expression of pro-apoptosis factors. Interestingly, only DHA-PC could improve the expression of neurotrophic factors, including BDNF, synaptophysin, and growth associated protein 43. DHA-PC and EPA-PC could ameliorate memory and cognitive function of HF diet-fed SAMP8 mice via inhibiting Aβ generation, suppressing oxidative stress and apoptosis, down-regulating inflammatory response, and improving neurotrophic activity. Therefore, DHA-PC and EPA-PC may be applied as food supplements and/or functional ingredients to relieve neurodegenerative disease.

EPA issues ANPR on significant new uses of lead

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bergeson, L.L.

1994-12-01

The US Environmental Protection Agency (EPA) signed off on an Advance Notice of Proposed Rulemaking (ANPR) for significant new uses of lead. The Significant New Use Rule (SNUR) would require people to notify EPA at least 90 days before commencing the manufacture, import or processing of lead and lead compounds for new uses. Section 5(a) of the Toxic Substances Control Act (TSCA) provides EPA with authority to screen new uses of a chemical substance to determine whether these uses should be regulated. The screening function is accomplished through the SNUR process. EPA may issue a SNUR for chemical substances aftermore » considering relevant factors including: the projected volume of manufacturing and processing of a chemical substance; the extent to which a use changes the type or form of human or environmental exposure to a chemical substance; the extent to which a new use increases the magnitude and duration of a human or environmental exposure to a chemical substance; and the reasonably anticipated manner and methods of manufacturing, processing, distribution in commerce and disposal of the chemical substance.« less

77 FR 75152 - Notice of Receipt of Pesticide Products; Registration Applications

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-19

... Products; Registration Applications AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: EPA has received applications to register pesticide products containing an active ingredient not included in any currently registered pesticide products. Pursuant to the Federal Insecticide, Fungicide...

National Enforcement Initiative: Keeping Raw Sewage and Contaminated Stormwater Out of Our Nation's Waters

EPA Pesticide Factsheets

This page describes EPA's enforcement activities on water pollution from raw sewage and contaminated stormwater. This is one of EPA's National Enforcement Initiatives. Both enforcement cases, and a map of enforcement actions are provided.

Laser Detection of Nanoparticles In the Environment

EPA Science Inventory

The United States Environmental Protection Agency (EPA) is charged by Congress to protect the nation’s natural resources. Under the mandate of national environmental laws, the EPA strives to formulate and implement actions leading to a compatible balance between human activities ...

75 FR 28606 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-21

... Recovery Operations (Renewal), EPA ICR Number 1717.07, OMB Control Number 2060-0313 AGENCY: Environmental... Operations (Renewal). ICR Numbers: EPA ICR Number 1717.07, OMB Control Number 2060-0313. ICR Status: This ICR...

75 FR 35453 - Agency Information Collection Activities; Submission To OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-22

... New and In-Use Portable Gasoline Containers (Renewal), EPA ICR 2213.03, OMB Control No. 2060-0597...-Use Portable Gasoline Containers (Renewal). ICR Numbers: EPA ICR No. 2213.03, OMB Control No. 2060...

75 FR 6200 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-08

... Production; EPA ICR Number 1788.09, OMB Control Number 2060-0417 AGENCY: Environmental Protection Agency (EPA... Control Number 2060-0388. ICR Status: This ICR is schedule to expire on February 28, 2010. Under OMB...

75 FR 35795 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-23

... Importation of Nonconforming Vehicles (Renewal); EPA ICR No. 0010.12, OMB Control No. 2060-0095 AGENCY... (Renewal). ICR Numbers: EPA ICR Number 0010.12, OMB Control No. 2060-0095. ICR Status: This ICR is...

75 FR 76978 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-10

... (Renewal), EPA ICR Number 1078.09, OMB Control Number 2060-0111 AGENCY: Environmental Protection Agency... Numbers: EPA ICR Number 1078.09, OMB Control Number 2060-0111. ICR Status: This ICR is scheduled to expire...

75 FR 43972 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-27

... Plant Incineration (Renewal), EPA ICR Number 1063.11, OMB Control Number 2060-0035 AGENCY: Environmental... Incineration (Renewal). ICR Numbers: EPA ICR Number 1063.11, OMB Control Number 2060-0035. ICR Status: This ICR...

75 FR 26955 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-13

... ICR Number 1058.10, OMB Control Number 2060-0040 AGENCY: Environmental Protection Agency (EPA). ACTION...: EPA ICR Number 1058.10, OMB Control Number 2060-0040. ICR Status: This ICR is scheduled to expire on...

75 FR 360 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-05

... Commercial and Industrial Sectors; EPA ICR No. 1772.05, OMB Control No. 2060-0347 AGENCY: Environmental... in the Commercial and Industrial Sectors. ICR Numbers: EPA ICR No. 1772.05, OMB Control No. 2060-0347...

75 FR 39250 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-08

... Protocol Gas Verification Program; EPA ICR No. 2375.01, OMB Control Number 2060-NEW AGENCY: Environmental... Air Protocol Gas Verification Program. ICR numbers: EPA ICR No. 2375.01, OMB Control No. 2060-NEW. ICR...

75 FR 1054 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-08

... (Renewal); EPA ICR Number 1128.09, OMB Control Number 2060-0080 AGENCY: Environmental Protection Agency... Numbers: EPA ICR Number 1128.09, OMB Control Number 2060-0080. ICR Status: This ICR is scheduled to expire...

75 FR 25851 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-10

... Manufacturing (Renewal), EPA ICR Number 2115.03, OMB Control Number 2060-0535 AGENCY: Environmental Protection... (Renewal) ICR Numbers: EPA ICR Number 2115.03, OMB Control Number 2060-0535. ICR Status: This ICR is...

77 FR 1930 - Agency Information Collection Activities; Proposed Collection; Comment Request; Clean Air...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-12

... Fine Particle Matter and Ozone (Renewal); EPA ICR No. 2152.05, OMB Control No. 2060-0570 AGENCY... Matter and Ozone (Renewal). ICR number: EPA ICR No. 2152.05, OMB Control No. 2060-0570. ICR Status: This...

75 FR 39247 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-08

... Plants, and Ferroalloy Production Facilities, (Renewal) EPA ICR Number 1604.09, OMB Control Number 2060... (Renewal) ICR Numbers: EPA ICR Number 1604.09, OMB Control Number 2060-0110. ICR Status: This ICR is...

75 FR 77867 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-14

... (Renewal), EPA ICR Number 1158.10, OMB Control Number 2060-0156 AGENCY: Environmental Protection Agency... Manufacturing (Renewal). ICR Numbers: EPA ICR Number 1158.10, OMB Control Number 2060-0156. ICR Status: This ICR...

75 FR 1053 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-08

... Parts for Business Machines, EPA ICR Number 1093.09, OMB Control Number 2060-0162 AGENCY: Environmental... Machines ICR Numbers: EPA ICR Number 1093.09, OMB Control Number 2060-0162. ICR Status: This ICR is...

75 FR 19382 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-14

... Cleaners (Renewal), EPA ICR Number 1652.07, OMB Control Number 2060- 0273 AGENCY: Environmental Protection...). ICR Numbers: EPA ICR Number 1652.07, OMB Control Number 2060-0273. ICR Status: This ICR is scheduled...

75 FR 19966 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-16

... Product (Renewal), EPA ICR Number 1783.05, OMB Control Number 2060-0357 AGENCY: Environmental Protection... (Renewal). ICR Numbers: EPA ICR Number 1783.05, OMB Control Number 2060-0357. ICR Status: This ICR is...

75 FR 7584 - Agency Information Collection Activities; Proposed Collection; Comment Request; EPA-ICR No. 1774...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-22

... Program, OMB Control No. 2060-0350 AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY.... 1774.05, OMB Control No. 2060-0350. ICR status: This ICR is currently scheduled to expire on July 31...

77 FR 26750 - Agency Information Collection Activities; Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-07

... identification, pass through a metal detector, and sign the EPA visitor log. All visitor bags are processed through an X-ray machine and subject to search. Visitors will be provided an EPA/DC badge that must be...

77 FR 71417 - Agency Information Collection Activities; Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-30

... identification, pass through a metal detector, and sign the EPA visitor log. All visitor bags are processed through an X-ray machine and subject to search. Visitors will be provided an EPA/DC badge that must be...

Semiannual Report: Oct 1, 2004 - Mar 31, 2005

EPA Pesticide Factsheets

Semiannual Report #EPA-350-R-05-002, April, 2005. During this semiannual reporting period, two of our more important activities focused on the efforts of the EPA to make air safe and healthy to breathe, and to help improve homeland security.

Report: EPA Needs to Conduct Environmental Justice Reviews of Its Programs, Policies, and Activities

EPA Pesticide Factsheets

Report #2006-P-00034, September 18, 2006. Our survey results showed that EPA senior management has not sufficiently directed program and regional offices to conduct environment justice reviews in accordance with Executive Order 12898.

77 FR 24486 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-24

... for Assistance Programs (Renewal); EPA ICR No. 0938.18 AGENCY: Environmental Protection Agency. ACTION...: EPA ICR No. 0938.18, OMB Control Number 2030-0020. ICR Status: This ICR is scheduled to expire on...

78 FR 26776 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-08

... number EPA-HQ- OECA-2012-0657, to: (1) EPA online, using www.regulations.gov (our preferred method), or... estimates that are attributed to the correction of mathematical discrepancies identified in the previous ICR...

ORAL PRESENTATION:EPA'S ENVIRONMENTAL PHOTOGRAPHIC INTERPRETATION CENTER (EPIC)

EPA Science Inventory

This presentation provides an overview of the remote sensing technical support and research and development activities of the Environmental Photographic Interprettion Center (EPIC). It is the basis for a presentation given at the EPA's Office of Acquisition Management's Annual C...

Earth Day Poster

EPA Science Inventory

In 1970, President Richard Nixon and Congress established the U.S. EPA in response to the growing public demand for cleaner water, air, and land. EPA was tasked with monitoring, standard-setting ,and enforcement activities to help protect our environment and to help Americans mak...

The Differential Effects of Eicosapentaenoic Acid and Docosahexaenoic Acid on Cardiometabolic Risk Factors: A Systematic Review

PubMed Central

Innes, Jacqueline K.; Calder, Philip C.

2018-01-01

A large body of evidence supports the cardioprotective effects of the long-chain omega-3 polyunsaturated fatty acids (PUFAs), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). There is increasing interest in the independent effects of EPA and DHA in the modulation of cardiometabolic risk factors. This systematic review aims to appraise the latest available evidence of the differential effects of EPA and DHA on such risk factors. A systematic literature review was conducted up to May 2017. Randomised controlled trials were included if they met strict eligibility criteria, including EPA or DHA > 2 g/day and purity ≥ 90%. Eighteen identified articles were included, corresponding to six unique studies involving 527 participants. Both EPA and DHA lowered triglyceride concentration, with DHA having a greater triglyceride-lowering effect. Whilst total cholesterol levels were largely unchanged by EPA and DHA, DHA increased high-density lipoprotein (HDL) cholesterol concentration, particularly HDL2, and increased low-density lipoprotein (LDL) cholesterol concentration and LDL particle size. Both EPA and DHA inhibited platelet activity, whilst DHA improved vascular function and lowered heart rate and blood pressure to a greater extent than EPA. The effects of EPA and DHA on inflammatory markers and glycaemic control were inconclusive; however both lowered oxidative stress. Thus, EPA and DHA appear to have differential effects on cardiometabolic risk factors, but these need to be confirmed by larger clinical studies. PMID:29425187

History of EPI Suite™ and future perspectives on chemical property estimation in US Toxic Substances Control Act new chemical risk assessments.

PubMed

Card, Marcella L; Gomez-Alvarez, Vicente; Lee, Wen-Hsiung; Lynch, David G; Orentas, Nerija S; Lee, Mari Titcombe; Wong, Edmund M; Boethling, Robert S

2017-03-22

Chemical property estimation is a key component in many industrial, academic, and regulatory activities, including in the risk assessment associated with the approximately 1000 new chemical pre-manufacture notices the United States Environmental Protection Agency (US EPA) receives annually. The US EPA evaluates fate, exposure and toxicity under the 1976 Toxic Substances Control Act (amended by the 2016 Frank R. Lautenberg Chemical Safety for the 21 st Century Act), which does not require test data with new chemical applications. Though the submission of data is not required, the US EPA has, over the past 40 years, occasionally received chemical-specific data with pre-manufacture notices. The US EPA has been actively using this and publicly available data to develop and refine predictive computerized models, most of which are housed in EPI Suite™, to estimate chemical properties used in the risk assessment of new chemicals. The US EPA develops and uses models based on (quantitative) structure-activity relationships ([Q]SARs) to estimate critical parameters. As in any evolving field, (Q)SARs have experienced successes, suffered failures, and responded to emerging trends. Correlations of a chemical structure with its properties or biological activity were first demonstrated in the late 19 th century and today have been encapsulated in a myriad of quantitative and qualitative SARs. The development and proliferation of the personal computer in the late 20 th century gave rise to a quickly increasing number of property estimation models, and continually improved computing power and connectivity among researchers via the internet are enabling the development of increasingly complex models.

Report of the 2016-17 Academic Affairs Standing Committee: Entrustable Professional Activities Implementation Roadmap.

PubMed

Pittenger, Amy L; Copeland, Debra A; Lacroix, Matthew M; Masuda, Quamrun N; Mbi, Peter; Medina, Melissa S; Miller, Susan M; Stolte, Scott K; Plaza, Cecilia M

2017-06-01

The purpose of this report is to: 1) Identify linkages across the EPA statements, Center for the Advancement of Pharmacy Education 2013 Educational Outcomes (CAPE 2013) and the Joint Commission of Pharmacy Practitioners' Pharmacist Patient Care Process (PPCP); 2) Provide ways EPA statements can be used to communicate core skills that are part of the entry-level pharmacist identity; 3) Suggest a potential roadmap for AACP members on how to implement EPA statements.

Statement of Intent between EPA and the European Chemicals Agency (ECHA)

EPA Pesticide Factsheets

This page contains a Statement of Intent between EPA and the European Chemicals Agency (ECHA) to exchange information, training and experience on chemical safety and the 2015-2016 Rolling Work Plan of activities to implement the Statement of Intent.

Notification: Review of Inspections and Evaluations of Clean Air Act Sources

EPA Pesticide Factsheets

Project #OPE-FY15-0015, March 12, 2015. The EPA OIG plans to begin preliminary research of the Office of Enforcement and Compliance Assurance (OECA) and selected EPA region's oversight of compliance assurance activities for major Clean Air Act sources.

LINKING WATERFOWL WITH CONTAMINANT SPECIATION IN RIPARIAN SOILS

EPA Science Inventory

This report summarizes the results of Mine Waste Technology Program (MWTP) Activity III, Project 38, Linking Waterfowl with Contaminant Speciation in Riparian Soils, implemented and funded by the U.S. Environmental Protection Agency (EPA) and jointly administered by EPA and the U...

76 FR 55905 - Agency Information Collection Activities; Proposed Collection; Comment Request; Requirements for...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-09

... submitting comments. E-mail: a-and-r[email protected] , Attention Docket ID No. EPA-HQ-OAR-2004-0073. Fax: (202... as CBI only to the following address: Mr. Roberto Morales, OAQPS Document Control Officer, U.S. EPA...

Do-It-Yourself Air Sensors – Exploring the Atmosphere and Turning on Light Bulbs!?

EPA Science Inventory

These are educational slides that will be presented in a webinar to the National Science Teachers Association. Topics covered include general air quality, current EPA research, and EPA's particle sensor kit that is a classroom activity.

Integrated Passive Biological Treatment System/ Mine Waste Technology Program Report #16

EPA Science Inventory

This report summarizes the results of the Mine Waste Technology Program (MWTP) Activity III, Project 16, Integrated, Passive Biological Treatment System, funded by the United States Environmental Protection Agency (EPA) and jointly administered by EPA and the United States Depar...

75 FR 67087 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-01

... Production Residual Risk and Technology Review (RTR); EPA ICR No. 2400.01, OMB Control Number 2060--NEW...: EPA ICR No. 2400.01, OMB Control No. 2060--New. ICR Status: This ICR is for a new information...

75 FR 9408 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-02

... Part 63, Subpart LLL), EPA ICR Number 1801.08, OMB Control Number 2060-0416 AGENCY: Environmental... Numbers: EPA ICR Number 1801.08, OMB Control Number 2060-0416. ICR Status: This ICR is scheduled to expire...

75 FR 76977 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-10

...-Institutional Steam Generating Units (Renewal), EPA ICR Number 1564.08, OMB Control Number 2060-0202 AGENCY...: EPA ICR Number 1564.08, OMB Control Number 2060-0202. ICR Status: This ICR is scheduled to expire on...

75 FR 13536 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-22

... Provisions (Renewal); EPA ICR No. 2228.03, OMB Control No. 2060-0587 AGENCY: Environmental Protection Agency... (Renewal). ICR Numbers: EPA ICR No. 2228.03, OMB Control No. 2060-0566. ICR Status: This ICR is scheduled...

75 FR 69659 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-15

... and other Agricultural Chemical Manufacturing), 9641 (Regulation of Agricultural Marketing and...) EPA online using http://www.regulations.gov (our preferred method), or by mail to: Office of Pesticide... under Docket ID No. EPA- [[Page 69660

77 FR 46089 - Agency Information Collection Activities; Proposed Collection; Comment Request; EPA's ENERGY STAR...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-02

[email protected] . Fax: (202) 566-9744. Mail: U.S. Environmental Protection Agency, EPA Docket Center, Air and Radiation Docket, Mail Code 28221T, 1200 Pennsylvania Avenue NW., Washington, DC 20460. Hand Delivery: Air... [[Page 46090

UPDATE ON EPA'S URBAN WATERSHED MANAGEMENT BRANCH MODELING ACTIVITIES

EPA Science Inventory

This paper provides the Stormwater Management Model (SWMM) user community with a description of the Environmental Protection Agency (EPA's) Office of Research and Development (ORD) approach to urban watershed modeling research and provides an update on current ORD SWMM-related pr...

LIMITED-USE CHEMICAL PROTECTIVE CLOTHING FOR EPA SUPERFUND ACTIVITIES

EPA Science Inventory

Because contractor field personnel complained about the poor durability and fit of limited-use chemical protective clothing (CPC) most commonly used at hazardous waste site operations, the U.S. Environmental Protection Agency (EPA) initiated a study to characterize use of CPC; de...

PERMEABLE TREATMENT WALL EFFECTIVENESS MONITORING PROJECT, NEVADA STEWART MINE

EPA Science Inventory

This report summarizes the results of Mine Waste Technology Program (MWTP) Activity III, Project 39, Permeable Treatment Wall Effectiveness Monitoring Project, implemented and funded by the U.S. Environmental Protection Agency (EPA) and jointly administered by EPA and the U.S. De...

Mine Waste Technology Program Electrochemical Tailings Cover

EPA Science Inventory

This report summarizes the results of Mine Waste Technology Program (MWTP) Activity III, Project 40, Electrochemical Tailings Cover, funded by the U.S. Environmental Protection Agency (EPA) and jointly administered by EPA and the U.S. Department of Energy (DOE). MSE Technology A...

PRN 97-5: Use of Common Names for Active Ingredients on Pesticide Labeling

EPA Pesticide Factsheets

This notice announces EPA policy to expand the use of common names on pesticide labeling. EPA will permit the use of common names approved by ANSI in the label ingredients statement without the accompanying scientific chemical name.

Legislative and Regulatory Authority for Reviewing New Chemicals under TSCA

EPA Pesticide Factsheets

Section 5 of the Toxic Substances Control Act (TSCA) gives EPA the authority to require anyone who plans to manufacture a new chemical substance for a non-exempt commercial purpose to provide EPA with notice 90 days before initiating the activity.

78 FR 18977 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-28

... preferred method), or by email to: [email protected] , or by mail to: EPA Docket Center (EPA/DC... in Agency burden is related to a mathematical error in the calculations, which led to double counting...

LIMITED-USE CHEMICAL PROTECTIVE CLOTHING FOR EPA SUPERFUND ACTIVITIES

EPA Science Inventory

Because contractor field personnel complained about the poor durability and fit of limited-use chemical protective clothing (CPC) most commonly used at hazardous waste site operations, the U.S. Environmental Protection Agency (EPA) initiated a study to • characterize use of CPC...

Civil Penalty Policies

EPA Pesticide Factsheets

The Environmental Protection Agency's Enforcement and Compliance History Online (ECHO) website provides customizable and downloadable information about environmental inspections, violations, and enforcement actions for EPA-regulated facilities, like power plants and factories. ECHO advances public information by sharing data related to facility compliance with and regulatory agency activity related to air, hazardous waste, clean water, and drinking water regulations. ECHO offers many user-friendly options to explore data, including:1. Facility Search (http://echo.epa.gov/facilities/facility-search?mediaSelected=all): ECHO information is searchable by varied criteria, including location, facility type, and compliance status related to the Clean Air Act, Clean Water Act, Resource Conservation and Recovery Act, and Safe Drinking Water Act. Search results are customizable and downloadable.2. Comparative Maps (http://echo.epa.gov/maps/state-comparative-maps) and State Dashboards (http://echo.epa.gov/trends/comparative-maps-dashboards/state-air-dashboard): These tools offer aggregated information about facility compliance status and regulatory agency compliance monitoring and enforcement activity at the national and state level.3. Bulk Data Downloads (http://echo.epa.gov/resources/echo-data/data-downloads): One of ECHO's most popular features is the ability to work offline by downloading large data sets. Users can take advantage of the ECHO Exporter, which provides su

EnviroAtlas - Austin, TX - Tree Cover Configuration and Connectivity, Water Background Web Service

EPA Pesticide Factsheets

This EnviroAtlas web service supports research and online mapping activities related to EnviroAtlas (https://enviroatlas.epa.gov/EnviroAtlas). The EnviroAtlas Austin, TX tree cover configuration and connectivity map categorizes forest land cover into structural elements (e.g. core, edge, connector, etc.). In this community, Forest is defined as Trees & Forest (Trees & Forest - 40 = 1; All Else = 0). Water was considered background (value 129) during the analysis to create this dataset, however it has been converted into value 10 to distinguish it from land area background. This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can be found in its associated EnviroAtlas Fact Sheet (https://www.epa.gov/enviroatlas/enviroatlas-fact-sheets).

EPA Facility Registry Service (FRS): TRI

EPA Pesticide Factsheets

This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link to the Toxic Release Inventory (TRI) System. TRI is a publicly available EPA database reported annually by certain covered industry groups, as well as federal facilities. It contains information about more than 650 toxic chemicals that are being used, manufactured, treated, transported, or released into the environment, and includes information about waste management and pollution prevention activities. FRS identifies and geospatially locates facilities, sites or places subject to environmental regulations or of environmental interest. Using vigorous verification and data management procedures, FRS integrates facility data from EPA's national program systems, other federal agencies, and State and tribal master facility records and provides EPA with a centrally managed, single source of comprehensive and authoritative information on facilities. This data set contains the subset of FRS integrated facilities that link to TRI facilities once the TRI data has been integrated into the FRS database. Additional information on FRS is available at the EPA website https://www.epa.gov/enviro/facility-registry-service-frs.

Differential effects of eicosapentaenoic acid and docosahexaenoic acid on human skin fibroblasts.

PubMed

Brown, E R; Subbaiah, P V

1994-12-01

To better understand the mode of action of omega 3 fatty acids in cell membranes, human foreskin fibroblasts were grown in serum-free medium supplemented with 50 microM oleic acid linoleic acid, eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA), and the effects on membrane composition, fluorescence polarization and enzyme activities were followed. The cells were enriched with EPA and DHA up to 7 and 13% of total lipids, respectively, of which > 95% was associated with phospholipids. In addition, the concentration of 22:5n-3 increased with both EPA and DHA to 7.5, and 2.1% of the total fatty acids, respectively. When compared to controls (oleic acid), cells treated with DHA showed a decrease in cholesterol, phospholipids, arachidonic acid (AA) and free cholesterol/phospholipid ratio (P < 0.05). In the presence of EPA, only decreases in AA and cholesterol were significant (P < 0.05). Membrane fluidity, assessed by fluorescence anisotropy, was increased 16% in cells enriched with DHA (P < 0.05), but showed no change with EPA or linoleic acid. There was an increase in membrane-associated 5'-nucleotidase (+27%) and adenylate cyclase (+19%) activities (P < 0.05), in DHA-enriched, but not in EPA-enriched cells, when compared with oleate controls. The studies show that incorporation of DHA, but not EPA, into cell membranes of fibroblasts alters membrane biophysical characteristics and function. We suggest that these two major n-3 fatty acids of fish oils have differential effects on cell membranes, and this may be related to the known differences in their physiological effects.

Region 9 Tribal Minor NSR: New Source General Application (Form NEW)

EPA Pesticide Factsheets

This form should be used to register New or Modified Minor Sources (except Oil and Gas Industry Sources until March 2, 2016) with proposed construction or modifications that are subject to minor NSR with the EPA Region 9 Tribal NSR Permitting Program.

Omega-3 fatty acids and inflammatory processes: from molecules to man.

PubMed

Calder, Philip C

2017-10-15

Inappropriate, excessive or uncontrolled inflammation contributes to a range of human diseases. Inflammation involves a multitude of cell types, chemical mediators and interactions. The present article will describe nutritional and metabolic aspects of omega-6 (n-6) and omega-3 (n-3) fatty acids and explain the roles of bioactive members of those fatty acid families in inflammatory processes. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are n-3 fatty acids found in oily fish and fish oil supplements. These fatty acids are capable of partly inhibiting many aspects of inflammation including leucocyte chemotaxis, adhesion molecule expression and leucocyte-endothelial adhesive interactions, production of eicosanoids like prostaglandins and leukotrienes from the n-6 fatty acid arachidonic acid and production of pro-inflammatory cytokines. In addition, EPA gives rise to eicosanoids that often have lower biological potency than those produced from arachidonic acid, and EPA and DHA give rise to anti-inflammatory and inflammation resolving mediators called resolvins, protectins and maresins. Mechanisms underlying the anti-inflammatory actions of EPA and DHA include altered cell membrane phospholipid fatty acid composition, disruption of lipid rafts, inhibition of activation of the pro-inflammatory transcription factor nuclear factor κB so reducing expression of inflammatory genes and activation of the anti-inflammatory transcription factor peroxisome proliferator-activated receptor γ. Animal experiments demonstrate benefit from EPA and DHA in a range of models of inflammatory conditions. Human trials demonstrate benefit of oral n-3 fatty acids in rheumatoid arthritis and in stabilizing advanced atherosclerotic plaques. Intravenous n-3 fatty acids may have benefits in critically ill patients through reduced inflammation. The anti-inflammatory and inflammation resolving actions of EPA, DHA and their derivatives are of clinical relevance. © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.

Omega-3 polyunsaturated fatty acids selectively inhibit growth in neoplastic oral keratinocytes by differentially activating ERK1/2

PubMed Central

Parkinson, Eric Kenneth

2013-01-01

The long-chain omega-3 polyunsaturated fatty acids (n-3 PUFAs)—eicosapentaenoic acid (EPA) and its metabolite docosahexaenoic acid (DHA)—inhibit cancer formation in vivo, but their mechanism of action is unclear. Extracellular signal-regulated kinase 1/2 (ERK1/2) activation and inhibition have both been associated with the induction of tumour cell apoptosis by n-3 PUFAs. We show here that low doses of EPA, in particular, inhibited the growth of premalignant and malignant keratinocytes more than the growth of normal counterparts by a combination of cell cycle arrest and apoptosis. The growth inhibition of the oral squamous cell carcinoma (SCC) lines, but not normal keratinocytes, by both n-3 PUFAs was associated with epidermal growth factor receptor (EGFR) autophosphorylation, a sustained phosphorylation of ERK1/2 and its downstream target p90RSK but not with phosphorylation of the PI3 kinase target Akt. Inhibition of EGFR with either the EGFR kinase inhibitor AG1478 or an EGFR-blocking antibody inhibited ERK1/2 phosphorylation, and the blocking antibody partially antagonized growth inhibition by EPA but not by DHA. DHA generated more reactive oxygen species and activated more c-jun N-terminal kinase than EPA, potentially explaining its increased toxicity to normal keratinocytes. Our results show that, in part, EPA specifically inhibits SCC growth and development by creating a sustained signalling imbalance to amplify the EGFR/ERK/p90RSK pathway in neoplastic keratinocytes to a supraoptimal level, supporting the chemopreventive potential of EPA, whose toxicity to normal cells might be reduced further by blocking its metabolism to DHA. Furthermore, ERK1/2 phosphorylation may have potential as a biomarker of n-3 PUFA function in vivo. PMID:23892603

Minimal food effect for eicosapentaenoic acid and docosahexaenoic acid bioavailability from omega-3-acid ethyl esters with an Advanced Lipid TechnologiesTM (ALT®)-based formulation.

PubMed

Lopez-Toledano, Miguel A; Thorsteinsson, Thorsteinn; Daak, Ahmed A; Maki, Kevin C; Johns, Colleen; Rabinowicz, Adrian L; Sancilio, Frederick D

The absorption of eicosapentaenoic acid (EPA; 20:5n-3) and docosahexaenoic acid (DHA; 22:6n-3) omega-3-acid ethyl esters (EEs) is influenced by food. There is a need for a formulation of EE that is less impacted by food effect. SC401 is a novel Advanced Lipid Technologies-based formulation of EPA-EE and DHA-EE. In the presence of an aqueous medium, Advanced Lipid Technologies forms stable micelles in situ independent of bile salt secretion. This effect is hypothesized to improve EPA-EE and DHA-EE bioavailability while it helps mitigate the food effect associated with their consumption. The aim of the article was to assess the effect of food on the bioavailability of DHA and EPA after a single oral dose of 1530 mg omega-3 fatty acids EE (SC401) in 24 healthy subjects under fasted and low-fat (9% of total calories from fat) and high-fat (50% of total calories from fat) meal conditions. This was a randomized, open-label, single-dose, 3-period, 3-way crossover study. Blood samples for pharmacokinetic analyses were taken at predose and at 0.5, 1, 2, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5, 7, 8, 10, 12 and 24 hours postdose. To assess the safety of the intervention, active monitoring of adverse events, physical examinations, vital signs, clinical laboratory assessments (chemistry, hematology, and urinalysis), and 12-lead electrocardiograms were conducted. SC401 showed high bioavailability of both EPA and DHA in fasted, low-fat meal, and high-fat meal conditions. No differences were found in SC401 DHA AUC 0-t (t = 24 hours) among the 3 conditions (91.69% high-fat/fasted, 97.12% low-fat/fasted, and 105.92% low-fat/high-fat; P > .05 in all cases). In contrast, SC401 EPA AUC 0-t was affected by food intake (179.06% high-fat/fasted, P < .0001; 150.05% low-fat/fasted, P < .0001) and the amount of fat taken with SC401 (83.80% low-fat/high-fat; P = .0009). SC401 was safe and well tolerated. A single dose of SC401 resulted in high levels of EPA and DHA total lipids in plasma in fasting and fed conditions. SC401 overcame the food effect for DHA and partially ameliorated it for EPA. SC401 represents a convenient option for treatment of severe hypertriglyceridemia, especially for patients under a restricted intake of dietary fat. Copyright © 2017 National Lipid Association. Published by Elsevier Inc. All rights reserved.

Computational toxicology as implemented by the U.S. EPA: providing high throughput decision support tools for screening and assessing chemical exposure, hazard and risk.

PubMed

Kavlock, Robert; Dix, David

2010-02-01

Computational toxicology is the application of mathematical and computer models to help assess chemical hazards and risks to human health and the environment. Supported by advances in informatics, high-throughput screening (HTS) technologies, and systems biology, the U.S. Environmental Protection Agency EPA is developing robust and flexible computational tools that can be applied to the thousands of chemicals in commerce, and contaminant mixtures found in air, water, and hazardous-waste sites. The Office of Research and Development (ORD) Computational Toxicology Research Program (CTRP) is composed of three main elements. The largest component is the National Center for Computational Toxicology (NCCT), which was established in 2005 to coordinate research on chemical screening and prioritization, informatics, and systems modeling. The second element consists of related activities in the National Health and Environmental Effects Research Laboratory (NHEERL) and the National Exposure Research Laboratory (NERL). The third and final component consists of academic centers working on various aspects of computational toxicology and funded by the U.S. EPA Science to Achieve Results (STAR) program. Together these elements form the key components in the implementation of both the initial strategy, A Framework for a Computational Toxicology Research Program (U.S. EPA, 2003), and the newly released The U.S. Environmental Protection Agency's Strategic Plan for Evaluating the Toxicity of Chemicals (U.S. EPA, 2009a). Key intramural projects of the CTRP include digitizing legacy toxicity testing information toxicity reference database (ToxRefDB), predicting toxicity (ToxCast) and exposure (ExpoCast), and creating virtual liver (v-Liver) and virtual embryo (v-Embryo) systems models. U.S. EPA-funded STAR centers are also providing bioinformatics, computational toxicology data and models, and developmental toxicity data and models. The models and underlying data are being made publicly available through the Aggregated Computational Toxicology Resource (ACToR), the Distributed Structure-Searchable Toxicity (DSSTox) Database Network, and other U.S. EPA websites. While initially focused on improving the hazard identification process, the CTRP is placing increasing emphasis on using high-throughput bioactivity profiling data in systems modeling to support quantitative risk assessments, and in developing complementary higher throughput exposure models. This integrated approach will enable analysis of life-stage susceptibility, and understanding of the exposures, pathways, and key events by which chemicals exert their toxicity in developing systems (e.g., endocrine-related pathways). The CTRP will be a critical component in next-generation risk assessments utilizing quantitative high-throughput data and providing a much higher capacity for assessing chemical toxicity than is currently available.

Industrial Hygiene Issues

NASA Technical Reports Server (NTRS)

Brisbin, Steven G.

1999-01-01

This breakout session is a traditional conference instrument used by the NASA industrial hygiene personnel as a method to convene personnel across the Agency with common interests. This particular session focused on two key topics, training systems and automation of industrial hygiene data. During the FY 98 NASA Occupational Health Benchmarking study, the training system under development by the U.S. Environmental Protection Agency (EPA) was deemed to represent a "best business practice." The EPA has invested extensively in the development of computer based training covering a broad range of safety, health and environmental topics. Currently, five compact disks have been developed covering the topics listed: Safety, Health and Environmental Management Training for Field Inspection Activities; EPA Basic Radiation Training Safety Course; The OSHA 600 Collateral Duty Safety and Health Course; and Key program topics in environmental compliance, health and safety. Mr. Chris Johnson presented an overview of the EPA compact disk-based training system and answered questions on its deployment and use across the EPA. This training system has also recently been broadly distributed across other Federal Agencies. The EPA training system is considered "public domain" and, as such, is available to NASA at no cost in its current form. Copies of the five CD set of training programs were distributed to each NASA Center represented in the breakout session. Mr. Brisbin requested that each NASA Center review the training materials and determine whether there is interest in using the materials as it is or requesting that EPA tailor the training modules to suit NASA's training program needs. The Safety, Health and Medical Services organization at Ames Research Center has completed automation of several key program areas. Mr. Patrick Hogan, Safety Program Manager for Ames Research Center, presented a demonstration of the automated systems, which are described by the following: (1) Safety, Health and Environmental Training. This system includes an assessment of training needs for every NASA Center organization, course descriptions, schedules and automated course scheduling, and presentation of training program metrics; (2) Safety and Health Inspection Information. This system documents the findings from each facility inspection, tracks abatement status on those findings and presents metrics on each department for senior management review; (3) Safety Performance Evaluation Profile. The survey system used by NASA to evaluate employee and supervisory perceptions of safety programs is automated in this system; and (4) Documentation Tracking System. Electronic archive and retrieval of all correspondence and technical reports generated by the Safety, Health and Medical Services Office are provided by this system.

77 FR 39699 - Agency Information Collection Activities; Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-05

... Budget (OMB). Before submitting the ICR, titled: ``Soil Fumigant Risk Mitigation'' and identified by EPA..., soil fumigant registrants, state and tribal lead agencies, and EPA. Title: Soil Fumigant Risk... ensure that risk mitigation measures necessary for reregistration eligibility for certain soil fumigant...

76 FR 7193 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-09

... purposes of collecting, validating, and verifying information, processing and maintaining information, and... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OECA-2010-0363; FRL-9265-1] Agency Information Collection... Processing Plants (Renewal) AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: In...

DATA QUALITY OBJECTIVES IN RESEARCH PLANNING AT MED: THREE CASE STUDIES

EPA Science Inventory

This course will give a quality assurance perspective to research planning by describing the Data Quality Objective Process....Written plans are mandatory for all EPA environmental data collection activities according to EPA Order 5360.1 CHG 1 and Federal Acquisition Regulations,...

76 FR 45553 - Agency Information Collection Activities: Proposed Collection; Comment Request; Establishing No...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-29

.../epahome/dockets.htm . FOR FURTHER INFORMATION CONTACT: Chris Laabs, Oceans and Coastal Protection Division... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OW-2011-0150; FRL-9446-4] Agency Information Collection... Section 312 (Renewal) AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: In...

STATUS OF EPA/DOE MOU TECHNICAL WORKGROUP ACTIVITIES: HG WASTE TREATMENT

EPA Science Inventory

EPA's Land Disposal Restrictions program currently has technology-specific treatment standards for hazardous wastes containing greater than or equal to 260ppm total mercury (Hg) (i.e., high Hg subcategory wastes). The treatment standards specify RMERC for high Hg subcategory wast...

Mine Waste Technology Program. Passive Treatment for Reducing Metal Loading

EPA Science Inventory

This report summarizes the results of Mine Waste Technology Program (MWTP) Activity III, Project 48, Passive Treatment Technology Evaluation for Reducing Metal Loading, funded by the U.S. Environmental Protection Agency (EPA) and jointly administered by EPA and the U.S. Departmen...

77 FR 37670 - Agency Information Collection Activities OMB Responses

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-22

... Generators, Transporters, and Waste Management Facilities under the RCRA Hazardous Waste Manifest System... without change. EPA ICR Number 1695.12; Emissions Certification and Compliance Requirements for Marine and... change. Withdrawn and Continue EPA ICR Number 2127.02; Conditional Exclusions from Solid Waste and...

MINE WASTE TECHNOLOGY PROGRAM - UNDERGROUND MINE SOURCE CONTROL DEMONSTRATION PROJECT

EPA Science Inventory

This report presents results of the Mine Waste Technology Program Activity III, Project 8, Underground Mine Source Control Demonstration Project implemented and funded by the U. S. Environmental Protection Agency (EPA) and jointly administered by EPA and the U. S. Department of E...

75 FR 43973 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-27

... Quality Standard Implementation Rule (Renewal), EPA ICR No. 2236.03, OMB Control No. 2060-0594 AGENCY...: EPA ICR No. 2236.03, OMB Control No. 2060-0594. ICR status: This ICR is scheduled to expire on July 31...

Envirofacts Data Warehouse

EPA Pesticide Factsheets

The Envirofacts Data Warehouse contains information from select EPA Environmental program office databases and provides access about environmental activities that may affect air, water, and land anywhere in the United States. The Envirofacts Warehouse supports its own web enabled tools as well as a host of other EPA applications.

EPA Settlement with UConn Resolves Improper PCB Disposal Activity

EPA Pesticide Factsheets

The University of Connecticut has taken steps to ensure its PCB waste is properly disposed of in the future to settle claims by the U.S. Environmental Protection Agency (EPA) that it improperly disposed of PCBs during a 2013 renovation project at its Storr

76 FR 62405 - Environmental Impacts Statements; Notice of Availability

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-07

... ENVIRONMENTAL PROTECTION AGENCY [ER-FRL-8999-4] Environmental Impacts Statements; Notice of Availability AGENCY: Office of Federal Activities, EPA. General Information (202) 564-1399 or http://www.epa.gov/compliance/nepa/ . Weekly receipt of Environmental Impact Statements Filed 09/26/2011 Through 09...

SUMMARY OF EPA'S RADON REDUCTION RESEARCH IN SCHOOLS DURING 1989-90

EPA Science Inventory

The report details radon mitigation research in schools conducted by EPA during 1989 and part of 1990. The major objective was to evaluate the potential of active subslab depressurization (ASD) in various geologic and climatic regions. The different geographic regions also pres...

SUMMARY OF EPA'S RADON REDUCTION RESEARCH IN SCHOOLS DURING 1989-90

EPA Science Inventory

The report details radon mitigation research in schools conducted by EPA during 1989 and part of 1990. he major objective was to evaluate the potential of active subslab depressurization (ASD) in various geologic and climatic regions. he different geographic regions also presente...

National Enforcement Initiatives for Fiscal Years 2014-2016: Keeping Raw Sewage and Contaminated Stormwater Out of Our Nation's Waters

EPA Pesticide Factsheets

This page describes EPA's enforcement activities on water pollution from raw sewage and contaminated stormwater. This is one of EPA's National Enforcement Initiatives. Both enforcement cases, and a map of enforcement actions are provided.

Application of active learning modalities to achieve medical genetics competencies and their learning outcome assessments

PubMed Central

Hagiwara, Nobuko

2017-01-01

The steadily falling costs of genome sequencing, coupled with the growing number of genetic tests with proven clinical validity, have made the use of genetic testing more common in clinical practice. This development has necessitated nongeneticist physicians, especially primary care physicians, to become more responsible for assessing genetic risks for their patients. Providing undergraduate medical students a solid foundation in genomic medicine, therefore, has become all the more important to ensure the readiness of future physicians in applying genomic medicine to their patient care. In order to further enhance the effectiveness of instructing practical skills in medical genetics, the emphasis of active learning modules in genetics curriculum at medical schools has increased in recent years. This is because of the general acceptance of a better efficacy of active learner-centered pedagogy over passive lecturer-centered pedagogy. However, an objective standard to evaluate students’ skill levels in genomic medicine achieved by active learning is currently missing. Recently, entrustable professional activities (EPAs) in genomic medicine have been proposed as a framework for developing physician competencies in genomic medicine. EPAs in genomic medicine provide a convenient guideline for not only developing genomic medicine curriculum but also assessing students’ competency levels in practicing genomic medicine. In this review, the efficacy of different types of active learning modules reported for medical genetics curricula is discussed using EPAs in genomic medicine as a common evaluation standard for modules’ learning outcomes. The utility of the EPAs in genomic medicine for designing active learning modules in undergraduate medical genetics curricula is also discussed. PMID:29276425

Defining a new diagnostic assessment parameter for wound care: Elevated protease activity, an indicator of nonhealing, for targeted protease-modulating treatment.

PubMed

Serena, Thomas E; Cullen, Breda M; Bayliff, Simon W; Gibson, Molly C; Carter, Marissa J; Chen, Lingyun; Yaakov, Raphael A; Samies, John; Sabo, Matthew; DeMarco, Daniel; Le, Namchi; Galbraith, James

2016-05-01

It is widely accepted that elevated protease activity (EPA) in chronic wounds impedes healing. However, little progress has occurred in quantifying the level of protease activity that is detrimental for healing. The aim of this study was to determine the relationship between inflammatory protease activity and wound healing status, and to establish the level of EPA above which human neutrophil-derived elastase (HNE) and matrix metalloproteases (MMP) activities correlate with nonhealing wounds. Chronic wound swab samples (n = 290) were collected from four wound centers across the USA to measure HNE and MMP activity. Healing status was determined according to percentage reduction in wound area over the previous 2-4 weeks; this was available for 211 wounds. Association between protease activity and nonhealing wounds was determined by receiver operating characteristic analysis (ROC), a statistical technique used for visualizing and analyzing the performance of diagnostic tests. ROC analysis showed that area under the curve (AUC) for HNE were 0.69 for all wounds and 0.78 for wounds with the most reliable wound trajectory information, respectively. For MMP, the corresponding AUC values were 0.70 and 0.82. Analysis suggested that chronic wounds having values of HNE >5 and/or MMP ≥13, should be considered wound healing impaired. EPA is indicative of nonhealing wounds. Use of a diagnostic test to detect EPA in clinical practice could enable clinicians to identify wounds that are nonhealing, thus enabling targeted treatment with protease modulating therapies. © 2016 by the Wound Healing Society.

Application of active learning modalities to achieve medical genetics competencies and their learning outcome assessments.

PubMed

Hagiwara, Nobuko

2017-01-01

The steadily falling costs of genome sequencing, coupled with the growing number of genetic tests with proven clinical validity, have made the use of genetic testing more common in clinical practice. This development has necessitated nongeneticist physicians, especially primary care physicians, to become more responsible for assessing genetic risks for their patients. Providing undergraduate medical students a solid foundation in genomic medicine, therefore, has become all the more important to ensure the readiness of future physicians in applying genomic medicine to their patient care. In order to further enhance the effectiveness of instructing practical skills in medical genetics, the emphasis of active learning modules in genetics curriculum at medical schools has increased in recent years. This is because of the general acceptance of a better efficacy of active learner-centered pedagogy over passive lecturer-centered pedagogy. However, an objective standard to evaluate students' skill levels in genomic medicine achieved by active learning is currently missing. Recently, entrustable professional activities (EPAs) in genomic medicine have been proposed as a framework for developing physician competencies in genomic medicine. EPAs in genomic medicine provide a convenient guideline for not only developing genomic medicine curriculum but also assessing students' competency levels in practicing genomic medicine. In this review, the efficacy of different types of active learning modules reported for medical genetics curricula is discussed using EPAs in genomic medicine as a common evaluation standard for modules' learning outcomes. The utility of the EPAs in genomic medicine for designing active learning modules in undergraduate medical genetics curricula is also discussed.

Impact of EPA ingestion on COX- and LOX-mediated eicosanoid synthesis in skin with and without a pro-inflammatory UVR challenge – Report of a randomised controlled study in humans

PubMed Central

Pilkington, Suzanne M; Rhodes, Lesley E; Al-Aasswad, Naser M I; Massey, Karen A; Nicolaou, Anna

2014-01-01

Scope Eicosapentaenoic acid (EPA), abundant in oily fish, is reported to reduce skin inflammation and provide photoprotection, potential mechanisms include competition with arachidonic acid (AA) for metabolism by cyclooxygenases/lipoxygenases to less pro-inflammatory mediators. We thus examine impact of EPA intake on levels of AA, EPA and their resulting eicosanoids in human skin with or without ultraviolet radiation (UVR) challenge. Methods and results In a double-blind randomised controlled study, 79 females took 5 g EPA-rich or control lipid for 12 wk. Pre- and post-supplementation, red blood cell and skin polyunsaturated fatty acids were assessed by GC, and eicosanoids from unexposed and UVR-exposed skin by LC-MS/MS. Active supplementation increased red blood cell and dermal EPA versus control (both p < 0.001), lowering relative AA:EPA content (4:1 versus 15:1 and 5:1 versus 11:1, respectively; both p < 0.001). Pre-supplementation, UVR increased PGE2, 12-hydroxyeicosatetraenoic acids, 12-HEPE (all p < 0.001) and PGE3 (p < 0.05). Post-EPA, PGE2 was reduced in unchallenged skin (p < 0.05) while EPA-derived PGE3 (non-sign) and 12-HEPE (p < 0.01) were elevated post-UVR. Thus, post-EPA, PGE2:PGE3 was lower in unchallenged (12:1 versus 28:1; p < 0.05) and UVR exposed (12:1 versus 54:1; p < 0.01) skin; 12-hydroxyeicosatetraenoic acids:12-HEPE was lower in UVR-exposed skin (3:1 versus 11:1; p < 0.001). Conclusion Dietary EPA augments skin EPA:AA content, shifting eicosanoid synthesis towards less pro-inflammatory species, and promoting a regulatory milieu under basal conditions and in response to inflammatory insult. PMID:24311515

Highly Purified Eicosapentaenoic Acid Increases Interleukin-10 Levels of Peripheral Blood Monocytes in Obese Patients With Dyslipidemia

PubMed Central

Satoh-Asahara, Noriko; Shimatsu, Akira; Sasaki, Yousuke; Nakaoka, Hidenori; Himeno, Akihiro; Tochiya, Mayu; Kono, Shigeo; Takaya, Tomohide; Ono, Koh; Wada, Hiromichi; Suganami, Takayoshi; Hasegawa, Koji; Ogawa, Yoshihiro

2012-01-01

OBJECTIVE It has recently been highlighted that proinflammatory (M1) macrophages predominate over anti-inflammatory (M2) macrophages in obesity, thereby contributing to obesity-induced adipose inflammation and insulin resistance. A recent clinical trial revealed that highly purified eicosapentaenoic acid (EPA) reduces the incidence of major coronary events. In this study, we examined the effect of EPA on M1/M2-like phenotypes of peripheral blood monocytes in obese dyslipidemic patients. RESEARCH DESIGN AND METHODS Peripheral blood monocytes were prepared from 26 obese patients without and 90 obese patients with dyslipidemia. Of the latter 90 obese patients with dyslipidemia, 82 patients were treated with or without EPA treatment (1.8 g daily) for 3 months. RESULTS Monocytes in obese patients with dyslipidemia showed a significantly lower expression of interleukin-10 (IL-10), an M2 marker, than those without dyslipidemia. EPA significantly increased serum IL-10 and EPA levels, the EPA/arachidonic acid (AA) ratio, and monocyte IL-10 expression and decreased the pulse wave velocity (PWV), an index of arterial stiffness, compared with the control group. After EPA treatment, the serum EPA/AA ratio was significantly correlated with monocyte IL-10 expression. Only increases in monocyte IL-10 expression and serum adiponectin were independent determinants of a decreased PWV by EPA. Furthermore, EPA significantly increased the expression and secretion of IL-10 in human monocytic THP-1 cells through a peroxisome proliferator–activated receptor (PPAR)γ-dependent pathway. CONCLUSIONS This study is the first to show that EPA increases the monocyte IL-10 expression in parallel with decrease of arterial stiffness, which may contribute to the antiatherogenic effect of EPA in obese dyslipidemic patients. PMID:22912426

RCRA/UST, Superfund, and EPCRA hotline training module. Introduction to superfund community involvement. Directive

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1996-03-01

This module covers EPA`s Superfund community involvement program, a set of requirements under the National Contingency Plan (NCP) designed to ensure that public is informed about site conditions and given the opportunity to comment on the proposed remedy of a Superfund site. The NCP serves to uphold the public`s right to voice opinions and express concerns about Superfund site activities. EPA must involve communities throughout Superfund process - particularly at critical decision-making steps in the process.

E-configuration structures of EPA and DHA derived from Euphausia superba and their significant inhibitive effects on growth of human cancer cell lines in vitro.

PubMed

Zheng, Weilong; Wang, Xudong; Cao, Wenjing; Yang, Bowen; Mu, Ying; Dong, Yuesheng; Xiu, Zhilong

2017-02-01

Many bioactive components such as poly-unsaturated fatty acids (e.g. EPA and DHA), phospholipids and astaxanthin are known in Antarctic krill (Euphausia superba) oil. The krill DHA and EPA are generally considered to be similar to natural ones. However, two chemical compounds which were separated from Antarctic krill oil and identified as EPA and DHA by HRESIMS and NMR acted much more effective inhibitive activities on growth of several cell lines (U937, K562, SMMC-7721, PC-3, MDA-MB-231, HL60 and MCF-7) than those from sturgeon liver and commercial fish oil. Taking MCF-7 as an example, the IC 50 values of Antarctic krill EPA and DHA were 14.01 and 19.94μM，while the IC 50 values of sturgeon liver and commercial fish EPA and DHA were 81.45, 73.13, 82.11 and 75.31μM, respectively. Raman spectra revealed that the Antarctic krill EPA and DHA have E-configuration structures, which were different from those in commercial fish oil. Additionally, the Antarctic krill EPA and DHA had no effects on human normal liver cell line HL7702. These results indicated that the Antarctic krill E-EPA and E-DHA had a great prospect in cancer therapy. Copyright © 2017 Elsevier Ltd. All rights reserved.

Toward Defining the Foundation of the MD Degree: Core Entrustable Professional Activities for Entering Residency.

PubMed

Englander, Robert; Flynn, Timothy; Call, Stephanie; Carraccio, Carol; Cleary, Lynn; Fulton, Tracy B; Garrity, Maureen J; Lieberman, Steven A; Lindeman, Brenessa; Lypson, Monica L; Minter, Rebecca M; Rosenfield, Jay; Thomas, Joe; Wilson, Mark C; Aschenbrener, Carol A

2016-10-01

Currently, no standard defines the clinical skills that medical students must demonstrate upon graduation. The Liaison Committee on Medical Education bases its standards on required subject matter and student experiences rather than on observable educational outcomes. The absence of such established outcomes for MD graduates contributes to the gap between program directors' expectations and new residents' performance.In response, in 2013, the Association of American Medical Colleges convened a panel of experts from undergraduate and graduate medical education to define the professional activities that every resident should be able to do without direct supervision on day one of residency, regardless of specialty. Using a conceptual framework of entrustable professional activities (EPAs), this Drafting Panel reviewed the literature and sought input from the health professions education community. The result of this process was the publication of 13 core EPAs for entering residency in 2014. Each EPA includes a description, a list of key functions, links to critical competencies and milestones, and narrative descriptions of expected behaviors and clinical vignettes for both novice learners and learners ready for entrustment.The medical education community has already begun to develop the curricula, assessment tools, faculty development resources, and pathways to entrustment for each of the 13 EPAs. Adoption of these core EPAs could significantly narrow the gap between program directors' expectations and new residents' performance, enhancing patient safety and increasing residents', educators', and patients' confidence in the care these learners provide in the first months of their residency training.

EnviroAtlas - Austin, TX - Demographics by Block Group

EPA Pesticide Factsheets

This EnviroAtlas dataset is a summary of key demographic groups for the EnviroAtlas community. This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can be found in its associated EnviroAtlas Fact Sheet (https://www.epa.gov/enviroatlas/enviroatlas-fact-sheets).

75 FR 33712 - Withdrawal of the Emission-Comparable Fuel Exclusion Under RCRA

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-15

...) directs EPA to use voluntary consensus standards in its regulatory activities unless to do so would be inconsistent with applicable law or otherwise impractical. Voluntary consensus standards are technical... are developed or adopted by voluntary consensus standards bodies. NTTAA directs EPA to provide...

ACTIVE AND SEMI-PASSIVE LIME TREATMENT OF ACID MINE DRAINAGE AT LEVIATHAN MINE, CALIFORNIA CAPSULE

EPA Science Inventory

As part of the Superfund Innovative Technology Evaluation (SITE) program, U.S. Environmental Protection Agency (EPA), National Risk Management Research Laboratory (NRMRL), in cooperation with EPA Region IX, the state of California, and the Atlantic Richfield Company (ARCO) evalua...

ACTIVE AND SEMI-PASSIVE LIME TREATMENT OF ACID MINE DRAINAGE AT LEVIATHAN MINE, CALIFORNIA BULLETIN

EPA Science Inventory

As part of the Superfund Innovative Technology Evaluation (SITE) program, U.S. Environmental Protection Agency (EPA) National Risk Management Research Laboratory (NRMRL), in cooperation with EPA Region IX, the state of California, and the Atlantic Richfield Company (ARCO) evaluat...

ACTIVE AND SEMI-PASSIVE LIME TREATMENT OF ACID MINE DRAINAGE AT LEVIATHAN MINE, CALIFORNIA ITER

EPA Science Inventory

As part of the Superfund Innovative Tecbnology Evaluation (SITE) program, U.S. Environmental Protection Agency (EPA), National Risk Management Research Laboratory (NRMRL), in cooperation with EPA Region IX, the state of California, and the Atlantic Richfield Company (ARCO) evalua...

78 FR 6091 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-29

... purposes of collecting, validating, and verifying information, processing and maintaining information, and... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OECA-2012-0496; FRL-9527-1] Agency Information Collection... Processing and Asphalt Roofing Manufacturing (Renewal), EPA ICR Number 2352.03 AGENCY: Environmental...

Glossary | STORET Legacy Data Center | US EPA

EPA Pesticide Factsheets

2014-06-06

The U.S. Environmental Protection Agency (EPA) maintains two data management systems containing water quality information for the nation's waters: the Legacy Data Center (LDC), and STORET. The LDC is a static, archived database and STORET is an operational system actively being populated with water quality data.

77 FR 37899 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-25

... Large Household and Commercial Appliances (Renewal) AGENCY: Environmental Protection Agency (EPA... Commercial Appliances (Renewal). ICR Numbers: EPA ICR Number 1954.05, OMB Control Number 2060-0457. ICR... household and commercial appliances facilities. Estimated Number of Respondents: 102. Frequency of Response...

1997 SOUTH CAROLINA EPA/EPSCOR PROGRAM—STRATEGIC IMPROVEMENT PLAN (SIP) AND MANAGEMENT

EPA Science Inventory

The SIP of the 1997 South Carolina EPA/EPSCoR Program encompasses the educational programs and management components.  The educational activities are addressed in terms of pre-college, undergraduate, graduate, and public science programs.  These results are summarized bel...

76 FR 80360 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-23

..., Oceans and Coastal Protection Division, (4504T), Environmental Protection Agency, 1200 Pennsylvania Ave... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OW-2008-0150; FRL-9508-9] Agency Information Collection... Clean Water Act (Renewal) AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: In...

Report: EPA Needs Accurate Data on Results of Pollution Prevention Grants to Maintain Program Integrity and Measure Effectiveness of Grants

EPA Pesticide Factsheets

Report #15-P-0276, September 4, 2015. Inaccurate reporting of results misrepresents the impacts of pollution prevention activities provided to the public, and misinforms EPA management on the effectiveness of its investment in the program.

Bibliography of Water Quality Research Reports.

ERIC Educational Resources Information Center

Environmental Protection Agency, Washington, DC. Office of Research and Development.

Prepared for the Environmental Protection Agency (EPA), this bibliography of published reports covers information concerning the advancement of water pollution control technology and knowledge. The reports provide a central source of information on the research, development, and demonstration activities in the water research program of the EPA,…

Organizations - I | STORET Legacy Data Center | US EPA

EPA Pesticide Factsheets

2007-05-16

The U.S. Environmental Protection Agency (EPA) maintains two data management systems containing water quality information for the nation's waters: the Legacy Data Center (LDC), and STORET. The LDC is a static, archived database and STORET is an operational system actively being populated with water quality data.

EVALUATION OF THE POTENTIAL CARCINOGENICITY OF ELECTROMAGNETIC FIELDS (EXTERNAL REVIEW DRAFT)

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA or Agency) is posting on this web site a draft document related to the potential adverse human health effects resulting from exposure to electromagnetic fields (EMF). This document was never finalized after EPA activities were discon...

EMERGENCY RESPONSE EQUIPMENT TO CLEAN UP HAZARDOUS CHEMICAL RELEASES AT SPILLS AND UNCONTROLLED WASTE SITES

EPA Science Inventory

This paper reviews some of the research activities of the U.S. Environmental Protection Agency (EPA) regarding the development of emergency response equipment to control hazardous chemical releases. Several devices and systems have been developed by EPA for environmental emergenc...

77 FR 37904 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-25

... Composites Production (Renewal) AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: In...: NESHAP for Reinforced Plastic Composites Production (Renewal) ICR Numbers: EPA ICR Number 1976.05, OMB...: Owners or operators of reinforced plastic composites production facilities. Estimated Number of...

Temporal Variation of VOCs in Soils from Groundwater to the Surface/Subslab

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) is charged by Congress with protecting the nation’s natural resources. Under the mandate of national environmental laws, the EPA strives to formulate and implement actions leading to a compatible balance between human activities and ...

77 FR 38623 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-28

... Other Solid Waste Incineration Units (Renewal) AGENCY: Environmental Protection Agency (EPA). ACTION...: Emission Guidelines for Existing Other Solid Waste Incineration Units (Renewal). ICR Numbers: EPA ICR... disclose the information. Respondents/Affected Entities: Owners or operators of other existing solid waste...

Vertical Distribution of VOCs in Soils from Groundwater to the Surface/Subslab

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) is charged by ongress with protecting the nation’s natural resources. Under the mandate of national environmental laws, the EPA strives to formulate and implement actions leading to a compatible balance between human activities and ...

Methods for Measuring Occurrence and Exposure From Viruses in Drinking and Recreational Water

EPA Science Inventory

The United States Environmental Protection Agency (EPA) has an active research program to develop and improve methods for detecting human enteric viruses in recreational, source, and drinking waters. EPA is also developing methods to measure exposure to waterborne viruses and ap...

THE EPA'S EMERGING FOCUS ON LIFE CYCLE ASSESSMENT

EPA Science Inventory

EPA has been actively engaged in LCA research since 1990 to help advance the methodology and application of life cycle thinking in decision making. Across the Agency consideration of the life cycle concept is increasing in the development of policies and programs. A major force i...

76 FR 37349 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-27

... Vegetable Oil Production (Renewal) AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY... for Solvent Extraction for Vegetable Oil Production (Renewal). ICR Numbers: EPA ICR Number 1947.05... disclose the information. Respondents/Affected Entities: Owners or operators of vegetable oil production...

Glossary | STORET Legacy Data Center | US EPA

EPA Pesticide Factsheets

2011-02-14

The U.S. Environmental Protection Agency (EPA) maintains two data management systems containing water quality information for the nation's waters: the Legacy Data Center (LDC), and STORET. The LDC is a static, archived database and STORET is an operational system actively being populated with water quality data.

Contacts | STORET Legacy Data Center | US EPA

EPA Pesticide Factsheets

2007-05-16

The U.S. Environmental Protection Agency (EPA) maintains two data management systems containing water quality information for the nation's waters: the Legacy Data Center (LDC), and STORET. The LDC is a static, archived database and STORET is an operational system actively being populated with water quality data.

Remedial Investigation Report for USATHAMA - RATSS Lake City Army Ammunition Plant, Independence, Missouri. Volume 2

DTIC Science & Technology

1990-06-01

Antimony is a metal which occurs both in the trivalent and pentavalent oxidation states (EPA 1980). Absorption of this metal via oral and inhalation...routes of exposure is low (EPA 1980). Humans and animals exposed acutely orally or through inhalation to either trivalent or pentavalent forms of...kg/day (Heywood et al. 1979); an uncertainty factor of 1,000 was used to derive the RfD. Chromium Chromium was detected in the monitoring well within

EnviroAtlas - Metrics for Austin, TX

EPA Pesticide Factsheets

This EnviroAtlas web service supports research and online mapping activities related to EnviroAtlas (https://enviroatlas.epa.gov/EnviroAtlas). The layers in this web service depict ecosystem services at the census block group level for the community of Austin, Texas. These layers illustrate the ecosystems and natural resources that are associated with clean air (https://enviroatlas.epa.gov/arcgis/rest/services/Communities/ESC_ATX_CleanAir/MapServer); clean and plentiful water (https://enviroatlas.epa.gov/arcgis/rest/services/Communities/ESC_ATX_CleanPlentifulWater/MapServer); natural hazard mitigation (https://enviroatlas.epa.gov/arcgis/rest/services/Communities/ESC_ATX_NaturalHazardMitigation/MapServer); climate stabilization (https://enviroatlas.epa.gov/arcgis/rest/services/Communities/ESC_ATX_ClimateStabilization/MapServer); food, fuel, and materials (https://enviroatlas.epa.gov/arcgis/rest/services/Communities/ESC_ATX_FoodFuelMaterials/MapServer); recreation, culture, and aesthetics (https://enviroatlas.epa.gov/arcgis/rest/services/Communities/ESC_ATX_RecreationCultureAesthetics/MapServer); and biodiversity conservation (https://enviroatlas.epa.gov/arcgis/rest/services/Communities/ESC_ATX_BiodiversityConservation/MapServer), and factors that place stress on those resources. EnviroAtlas allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the conterminous United States as well as de

Synthesis of docosahexaenoic acid from eicosapentaenoic acid in retina neurons protects photoreceptors from oxidative stress

PubMed Central

Simón, María Victoria; Agnolazza, Daniela L.; German, Olga Lorena; Garelli, Andrés; Politi, Luis E.; Agbaga, Martin-Paul; Anderson, Robert E.; Rotstein, Nora P.

2015-01-01

Oxidative stress is involved in activating photoreceptor death in several retinal degenerations. Docosahexaenoic acid (DHA), the major polyunsaturated fatty acid in the retina, protects cultured retina photoreceptors from apoptosis induced by oxidative stress and promotes photoreceptor differentiation. Here we investigated whether eicosapentaenoic acid (EPA), a metabolic precursor to DHA, had similar effects and whether retinal neurons could metabolize EPA to DHA. Adding EPA to rat retina neuronal cultures increased opsin expression and protected photoreceptors from apoptosis induced by the oxidants paraquat (PQ) and hydrogen peroxide (H2O2). Palmitic, oleic, and arachidonic acids had no protective effect, showing the specificity for DHA. We found that EPA supplementation significantly increased DHA percentage in retinal neurons, but not EPA percentage. Photoreceptors and glial cells expressed Δ6 desaturase (FADS2), which introduces the last double bond in DHA biosynthetic pathway. Pre-treatment of neuronal cultures with CP-24879 hydrochloride, a Δ5/Δ6 desaturase inhibitor, prevented EPA-induced increase in DHA percentage and completely blocked EPA protection and its effect on photoreceptor differentiation. These results suggest that EPA promoted photoreceptor differentiation and rescued photoreceptors from oxidative stress-induced apoptosis through its elongation and desaturation to DHA. Our data show, for the first time, that isolated retinal neurons can synthesize DHA in culture. PMID:26662863

Determination of the Relative Efficacy of Eicosapentaenoic Acid and Docosahexaenoic Acid for Anti-Cancer Effects in Human Breast Cancer Models

PubMed Central

Mazurak, Vera C.; Damaraju, Sambasivarao

2017-01-01

Epidemiological studies have associated high fish oil consumption with decreased risk of breast cancer (BC). n-3 long chain polyunsaturated fatty acids (n-3 LCPUFA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) found in fish and fish oils exert anti-cancer effects. However, few studies have examined the relative efficacy of EPA and DHA alone and in mixtures on BC subtypes. This was the objective of the present review, as this research is a necessity for the translation of findings to human health and disease. The literature suggests that DHA has a greater anti-cancer effect in triple negative BC (TNBC). In estrogen positive (ER+) BC, DHA has a greater effect on cell viability, while both fatty acids have similar effects on apoptosis and proliferation. These effects are associated with preferential uptake of DHA into TNBC lipid rafts and EPA in ER+ BC. EPA:DHA mixtures have anti-cancer activity; however, the ratio of EPA:DHA does not predict the relative incorporation of these two fatty acids into membrane lipids as EPA appears to be preferentially incorporated. In summary, DHA and EPA should be considered separately in the context of BC prevention. The elucidation of optimal EPA:DHA ratios will be important for designing targeted n-3 LCPUFA treatments. PMID:29207553

The Environmental Protection Agency in the Early Trump Administration: Prelude to Regulatory Capture.

PubMed

Dillon, Lindsey; Sellers, Christopher; Underhill, Vivian; Shapiro, Nicholas; Ohayon, Jennifer Liss; Sullivan, Marianne; Brown, Phil; Harrison, Jill; Wylie, Sara

2018-04-01

We explore and contextualize changes at the Environmental Protection Agency (EPA) over the first 6 months of the Trump administration, arguing that its pro-business direction is enabling a form of regulatory capture. We draw on news articles, public documents, and a rapid response, multisited interview study of current and retired EPA employees to (1) document changes associated with the new administration, (2) contextualize and compare the current pro-business makeover with previous ones, and (3) publicly convey findings in a timely manner. The lengthy, combined experience of interviewees with previous Republican and Democratic administrations made them valuable analysts for assessing recent shifts at the Scott Pruitt-led EPA and the extent to which these shifts steer the EPA away from its stated mission to "protect human and environmental health." Considering the extent of its pro-business leanings in the absence of mitigating power from the legislative branch, we conclude that its regulatory capture has become likely-more so than at similar moments in the agency's 47-year history. The public and environmental health consequences of regulatory capture of the EPA will probably be severe and far-reaching.

The Environmental Protection Agency in the Early Trump Administration: Prelude to Regulatory Capture

PubMed Central

Sellers, Christopher; Underhill, Vivian; Shapiro, Nicholas; Ohayon, Jennifer Liss; Sullivan, Marianne; Brown, Phil; Harrison, Jill; Wylie, Sara

2018-01-01

We explore and contextualize changes at the Environmental Protection Agency (EPA) over the first 6 months of the Trump administration, arguing that its pro-business direction is enabling a form of regulatory capture. We draw on news articles, public documents, and a rapid response, multisited interview study of current and retired EPA employees to (1) document changes associated with the new administration, (2) contextualize and compare the current pro-business makeover with previous ones, and (3) publicly convey findings in a timely manner. The lengthy, combined experience of interviewees with previous Republican and Democratic administrations made them valuable analysts for assessing recent shifts at the Scott Pruitt–led EPA and the extent to which these shifts steer the EPA away from its stated mission to “protect human and environmental health.” Considering the extent of its pro-business leanings in the absence of mitigating power from the legislative branch, we conclude that its regulatory capture has become likely—more so than at similar moments in the agency’s 47-year history. The public and environmental health consequences of regulatory capture of the EPA will probably be severe and far-reaching. PMID:29698086

The Effects of an Oral Supplement Enriched With Fish Oil, Prebiotics, and Antioxidants on Nutrition Status in Crohn’s Disease Patients

PubMed Central

Wiese, Dawn M.; Lashner, Bret A.; Lerner, Edith; DeMichele, Stephen J.; Seidner, Douglas L.

2015-01-01

Background Research in the treatment of Crohn’s disease (CD) supports anti-inflammatory benefits of n-3 fatty acids from fish oil, prebiotics, and antioxidants. A nutritionally balanced inflammatory bowel disease nutrition formula (IBDNF) enriched with these compounds has the potential to improve nutrition status and disease activity in CD. Methods This is an open-label pilot study investigating the effects of IBDNF on nutrition status in CD patients. Twenty-eight patients with active CD on stable medication were asked to consume 16 oz of IBDNF/d for 4 months. Nutrition status was assessed with dual-energy X-ray absorptiometry scans and serum micronutrient levels. Disease activity and quality of life were measured using the Crohn’s Disease Activity Index (CDAI) and the Inflammatory Bowel Disease Questionnaire (IBDQ). Results Twenty patients completed the final visit. After 4 months, there was a significant decrease in plasma phospholipid levels of arachidonic acid with increases in eicosapentaenoic acid (EPA) and docosahexaenoic acid. Ten patients had a final EPA concentration of >2%. There was improvement in fat-free and fat mass in patients with final EPA >2% (P = .014 and P = .05). Vitamin D (25-OH) levels improved in all patients (18.5–25.9 ng/mL, P < .001). Those with EPA >2% had significantly lower CDAI (116 ± 94.5 vs 261.8 ± 86.5; P = .005) and higher IBDQ (179.1 ± 26.6 vs 114.6 ± 35.9, P < .001) compared to those with EPA <2%. Conclusions IBDNF has the potential to deposit fat-free and fat mass, improve vitamin D status, and improve quality of life in CD patients. PMID:21775642

40 CFR 30.12 - Forms for applying for Federal assistance.

Code of Federal Regulations, 2012 CFR

2012-07-01

... particular State can be obtained from EPA or the Catalog of Federal Domestic Assistance. The SPOC shall... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Forms for applying for Federal assistance. 30.12 Section 30.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER...

40 CFR 30.12 - Forms for applying for Federal assistance.

Code of Federal Regulations, 2014 CFR

2014-07-01

... particular State can be obtained from EPA or the Catalog of Federal Domestic Assistance. The SPOC shall... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Forms for applying for Federal assistance. 30.12 Section 30.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER...

40 CFR 30.12 - Forms for applying for Federal assistance.

Code of Federal Regulations, 2011 CFR

2011-07-01

... particular State can be obtained from EPA or the Catalog of Federal Domestic Assistance. The SPOC shall... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Forms for applying for Federal assistance. 30.12 Section 30.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER...

40 CFR 30.12 - Forms for applying for Federal assistance.

Code of Federal Regulations, 2010 CFR

2010-07-01

... particular State can be obtained from EPA or the Catalog of Federal Domestic Assistance. The SPOC shall... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Forms for applying for Federal assistance. 30.12 Section 30.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER...

40 CFR 30.12 - Forms for applying for Federal assistance.

Code of Federal Regulations, 2013 CFR

2013-07-01

... particular State can be obtained from EPA or the Catalog of Federal Domestic Assistance. The SPOC shall... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Forms for applying for Federal assistance. 30.12 Section 30.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER...

Deconstruction Rapid Assessment Tool

EPA Pesticide Factsheets

Deconstruction Rapid Assessment Tool (EPA 905-F-15-001) instructions, form and spreadsheet for assessing and triaging structures being considered for deconstruction. Promote environmental stewardship and economic revitalization through deconstruction.

Using the Entrustable Professional Activities Framework in the Assessment of Procedural Skills.

PubMed

Pugh, Debra; Cavalcanti, Rodrigo B; Halman, Samantha; Ma, Irene W Y; Mylopoulos, Maria; Shanks, David; Stroud, Lynfa

2017-04-01

The entrustable professional activity (EPA) framework has been identified as a useful approach to assessment in competency-based education. To apply an EPA framework for assessment, essential skills necessary for entrustment to occur must first be identified. Using an EPA framework, our study sought to (1) define the essential skills required for entrustment for 7 bedside procedures expected of graduates of Canadian internal medicine (IM) residency programs, and (2) develop rubrics for the assessment of these procedural skills. An initial list of essential skills was defined for each procedural EPA by focus groups of experts at 4 academic centers using the nominal group technique. These lists were subsequently vetted by representatives from all Canadian IM training programs through a web-based survey. Consensus (more than 80% agreement) about inclusion of each item was sought using a modified Delphi exercise. Qualitative survey data were analyzed using a framework approach to inform final assessment rubrics for each procedure. Initial lists of essential skills for procedural EPAs ranged from 10 to 24 items. A total of 111 experts completed the national survey. After 2 iterations, consensus was reached on all items. Following qualitative analysis, final rubrics were created, which included 6 to 10 items per procedure. These EPA-based assessment rubrics represent a national consensus by Canadian IM clinician educators. They provide a practical guide for the assessment of procedural skills in a competency-based education model, and a robust foundation for future research on their implementation and evaluation.

Eicosapentaenoic acid membrane incorporation impairs ABCA1-dependent cholesterol efflux via a protein kinase A signaling pathway in primary human macrophages.

PubMed

Fournier, Natalie; Tardivel, Sylviane; Benoist, Jean-François; Vedie, Benoît; Rousseau-Ralliard, Delphine; Nowak, Maxime; Allaoui, Fatima; Paul, Jean-Louis

2016-04-01

A diet rich in n-3/n-6 polyunsaturated fatty acids (PUFAs) is cardioprotective. Dietary PUFAs affect the cellular phospholipids composition, which may influence the function of membrane proteins. We investigated the impact of the membrane incorporation of several PUFAs on ABCA1-mediated cholesterol efflux, a key antiatherogenic pathway. Arachidonic acid (AA) (C20:4 n-6) and docosahexaenoic acid (DHA) (C22:6 n-3) decreased or increased cholesterol efflux from J774 mouse macrophages, respectively, whereas they had no effect on efflux from human monocyte-derived macrophages (HMDM). Importantly, eicosapentaenoic acid (EPA) (C20:5 n-3) induced a dose-dependent reduction of ABCA1 functionality in both cellular models (-28% for 70μM of EPA in HMDM), without any alterations in ABCA1 expression. These results show that PUFA membrane incorporation does not have the same consequences on cholesterol efflux from mouse and human macrophages. The EPA-treated HMDM exhibited strong phospholipid composition changes, with high levels of both EPA and its elongation product docosapentaenoic acid (DPA) (C22:5 n-3), which is associated with a decreased level of AA. In HMDM, EPA reduced the ATPase activity of the membrane transporter. Moreover, the activation of adenylate cyclase by forskolin and the inhibition of cAMP phosphodiesterase by isobutylmethylxanthine restored ABCA1 cholesterol efflux in EPA-treated human macrophages. In conclusion, EPA membrane incorporation reduces ABCA1 functionality in mouse macrophages as well as in primary human macrophages and this effect seems to be PKA-dependent in human macrophages. Copyright © 2016 Elsevier B.V. All rights reserved.

Translating exercise interventions to an in-home setting for seniors: preliminary impact on physical activity and function.

PubMed

Dondzila, Christopher J; Swartz, Ann M; Keenan, Kevin G; Harley, Amy E; Azen, Razia; Strath, Scott J

2016-12-01

The purpose of this study is to investigate whether an in-home, individually tailored intervention is efficacious in promoting increases in physical activity (PA) and improvements in physical functioning (PF) in low-active older adults. Participants were randomized to two groups for the 8-week intervention. The enhanced physical activity (EPA) group received individualized exercise programming, including personalized step goals and a resistance band training program, and the standard of care (SoC) group received a general activity goal. Pre- and post-intervention PF measures included choice step reaction time, knee extension/flexion strength, hand grip strength, and 8 ft up and go test completion time. Thirty-nine subjects completed this study (74.6 ± 6.4 years). Significant increases in steps/day were observed for both the EPA and SoC groups, although the improvements in the EPA group were significantly higher when including only those who adhered to weekly step goals. Both groups experienced significant PF improvements, albeit greater in the EPA group for the 8 ft up and go test and knee extension strength. A low cost, in-home intervention elicited improvements in both PA and PF. Future research is warranted to expand upon the size and scope of this study, exploring dose thresholds (and time frames) for PA to improve PF and strategies to further bolster adherence rates to maximize intervention benefits.

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