Science.gov

Sample records for activity guide includes

  1. ZOOMsci Activity Guide.

    ERIC Educational Resources Information Center

    Wade, Meredith

    This activity guide is based on the Public Broadcasting System's (PBS) program "ZOOM." It is designed for educators with activities that are categorized into three themes: (1) Things That Go, which includes "Air" which explores air pressure, "Rubber Bands" which discovers the potential energy of rubber bands, "Baking Soda and Vinegar" which…

  2. Woodsy Owl Activity Guide.

    ERIC Educational Resources Information Center

    Forest Service (USDA), Washington, DC.

    This guide offers teachers and after-school group leaders 12 fun and engaging activities. Activities feature lessons on trees, water, wind, the earth, food, and waste. The activities are designed to help children aged 5-8 become more aware of the natural environment and fundamental conservation principles. Titles of children's books are embedded…

  3. A Guide to Running a Recycling Project. [Includes Recycling Handbook].

    ERIC Educational Resources Information Center

    Oregon Recycling Information and Organizing Network, Portland.

    This guide, designed for both students and adults, is intended for individuals who feel they might be interested in establishing a recycling depot. The guide includes such pertinent information as deciding how to set up a depot, markets and transportation, preparation of materials, where to place the depot and when to operate it, publicity and…

  4. 4-H Horticulture Project Activity Guides. Leader's Guide and Units 1-3.

    ERIC Educational Resources Information Center

    Illinois Univ., Urbana. Cooperative Extension Service.

    This document, concerning the 4-H horticulture project, includes a leader's guide and three youth activity guides. The leader's guide can be used to plan group project meetings that are both fun and educational. Activities can be adapted to various age groups. The leader's guide includes basic information for growing plants indoors and outdoors,…

  5. Building Big with David Macaulay. Activity Guide.

    ERIC Educational Resources Information Center

    Sammons, James; Sammons, Fran Lyons; Curtis, Paul

    This activity guide is designed for educators and features suggestions for possible activity paths for different amounts of available time and survival tips for activity leaders. Each activity is divided into two sections--educator ideas and activity handouts. Activity sections include: (1) Foundations; (2) Bridges; (3) Domes; (4) Skyscrapers; (5)…

  6. Parents Who Care: A Step-by-Step Guide for Families with Teens. [Video Included].

    ERIC Educational Resources Information Center

    Hawkins, J. David; Catalano, Richard F.

    The world can be a risky place for teenagers in the 1990s. This guide and videotape provide skills for parents who want to help teens move successfully through the steps from childhood to adulthood. Based on extensive research, each of the seven units in the guide includes advice, strategies, and activities for both parents and teens to improve…

  7. Special Effects Activity Guide.

    ERIC Educational Resources Information Center

    Boxer, Jennifer; Valenta, Carol

    This guide accompanies "Special Effects," a 40-minute IMAX film and "Special Effects II", a multimedia, interactive traveling exhibit designed by the California Museum of Science and Industry. The exhibit focuses on the underlying scientific and technical processes of special effects from the earliest motion picture to state-of-the-art digital…

  8. Solar Energy Education. Home economics: teacher's guide. Field test edition. [Includes glossary

    SciTech Connect

    Not Available

    1981-06-01

    An instructional aid is provided for home economics teachers who wish to integrate the subject of solar energy into their classroom activities. This teacher's guide was produced along with the student activities book for home economics by the US Department of Energy Solar Energy Education. A glossary of solar energy terms is included. (BCS)

  9. Office Reprographics. Instructor's Guide. Student Activity Packet. Office Occupations.

    ERIC Educational Resources Information Center

    Johnson, Diane E.

    This training package, one in a series of instructional modules consisting of an instructor's guide and a student activity packet, deals with office reprographics. Included in the instructor's guide are general directions for implementing the presentation; a detailed guide for teaching the lesson that includes performance objectives, suggestions…

  10. Selected Technology Lab Activities Implementation Guide.

    ERIC Educational Resources Information Center

    Portland Public Schools, OR.

    These materials supplement state guides for junior high or middle school technology education programs. The materials show instructors how to implement 81 hours of new technology-related activities into existing programs. Introductory materials include a rationale, philosophy, and goals for technology education. Areas of instruction are as…

  11. Simple electron beam guiding system including automatic capture circuitry

    NASA Astrophysics Data System (ADS)

    Stein, W.; Schulenburg, M.; Freund, F.

    1980-08-01

    The spatial stability of the point of impact of an electron beam is a stringent requirement in some experiments such as soft x-ray spectroscopy using a focussing curved crystal spectrometer. The occasinally poor design of moderately priced electron guns, thermal instabilities, electromagnetic stray fields and so on, make spot stabilization an arduous task. The problem can be solved to some extent by a simple electron beam guiding system: a small fraction of the electron beam is captured by a metal wire mounted in the vicinity of the target. The beam position is fixed, if this fraction is controlled by a feedback loop via the deflection plates of the gun.

  12. Rockets: Physical science teacher's guide with activities

    NASA Technical Reports Server (NTRS)

    Vogt, Gregory L.; Rosenberg, Carla R. (Editor)

    1993-01-01

    This guide begins with background information sections on the history of rocketry, scientific principles, and practical rocketry. The sections on scientific principles and practical rocketry are based on Isaac Newton's three laws of motion. These laws explain why rockets work and how to make them more efficient. The background sections are followed with a series of physical science activities that demonstrate the basic science of rocketry. Each activity is designed to be simple and take advantage of inexpensive materials. Construction diagrams, materials and tools lists, and instructions are included. A brief discussion elaborates on the concepts covered in the activities and is followed with teaching notes and discussion questions. The guide concludes with a glossary of terms, suggested reading list, NASA educational resources, and an evaluation questionnaire with a mailer.

  13. Ball Screw Actuator Including a Stop with an Integral Guide

    NASA Technical Reports Server (NTRS)

    Wingett, Paul T. (Inventor); Perek, John (Inventor); Geck, Kellan (Inventor)

    2015-01-01

    An actuator includes a housing assembly, a ball nut, a ball screw, and a ball screw stop. The ball nut is rotationally mounted in the housing assembly, is adapted to receive an input torque, and is configured, upon receipt thereof, to rotate and supply a drive force. The ball screw is mounted within the housing assembly and extends through the ball nut. The ball screw has a first end and a second end, and is coupled to receive the drive force from the ball nut. The ball screw is configured, upon receipt of the drive force, to selectively translate between a stow position and a deploy position. The ball screw stop is mounted on the ball screw to translate therewith and is configured to at selectively engage the housing assembly while the ball screw is translating, and engage the ball nut when the ball screw is in the deploy position.

  14. Canada's physical activity guides: background, process, and development.

    PubMed

    Sharratt, Michael T; Hearst, William E

    2007-01-01

    This historical background paper chronicles the major events leading to the development of Canada's physical activity guides (for children, youth, adults, and older adults). The paper outlines the process and the steps used, including information (where applicable) regarding national partners, project administration, Health Canada communications, product development, endorsement, distribution and implementation, collateral activities, media relations and evaluation framework. Brief summaries of the science that led to the recommended guidelines are included. The paper also summarizes the various physical activity guide assessment and evaluation projects and their findings, particularly as they relate to research carried out on Canada's physical activity guides for children and youth (and the associated support resources). PMID:18213939

  15. Student Activity Guide for "Business in an Information Economy."

    ERIC Educational Resources Information Center

    Graf, David; And Others

    The 20 chapters of this student activity guide provide study guides (key terms and concepts reviews), projects, cases for analyses, and self-assessment exercises for business and career education classes. Topics covered include the following: business winners (entrepreneurship); growth of the U.S. economy, the basics of economics, comparing…

  16. Tornadoes: Nature's Most Violent Storms. A Preparedness Guide Including Safety Information for Schools.

    ERIC Educational Resources Information Center

    American National Red Cross, Washington, DC.

    This preparedness guide explains and describes tornadoes, and includes safety information for schools. A tornado is defined as a violently rotating column of air extending from a thunderstorm to the ground. The guide explains the cause of tornadoes, provides diagrams of how they form, describes variations of tornadoes, and classifies tornadoes by…

  17. Space based astronomy: Teacher's guide with activities

    NASA Technical Reports Server (NTRS)

    Rosenberg, Carla B. (Editor); Weiler, Edward; Morrow, Cherilyn; Bacon, Pamela M.; Thorne, Muriel; Blanchard, Paul A.; Howard, Sethane; Pengra, Patricia R.; Brown, Deborah A.; Winrich, Ralph

    1994-01-01

    This curriculum guide uses hands-on activities to help students and teachers understand the significance of space-based astronomy - astronomical observations made from outer space. The guide contains few of the traditional activities found in many astronomy guides such as constellation studies, lunar phases, and planetary orbits. Instead, it tells the story of why it is important to observe celestial objects from outer space and how to study the entire electromagnetic spectrum. The guide begins with a survey of astronomy related NASA spacecraft. This is followed by a collection of activities in four units: (1) the atmospheric filter; (2) the electromagnetic spectrum; (3) collecting electromagnetic radiation; and (4) down to Earth. A curriculum index identifies the curriculum areas each activity addresses. The guide concludes with a glossary, reference list, a NASA Resources list, and an evaluation card. It is designed for students in grades 5 through 8.

  18. Education: Guide to European Organizations and Programmes. A Guide to European Organizations Involved in Education, including Individual Programmes and Projects.

    ERIC Educational Resources Information Center

    Hayes, Heledd

    This report presents a guide to European organizations involved in education, including individual programs and projects. Entries are brief as they are intended as simple outlines of the organizations or programs, but full addresses and telephone numbers are provided. Divided into four categories, the organizations listed are as follows: (1)…

  19. Project WET: Curriculum & Activity Guide. K-12.

    ERIC Educational Resources Information Center

    Nelson, Dennis; And Others

    Project WET (Water Education for Teachers) is a nonprofit water education program for educators and young people. This curriculum and activity guide for kindergarten through twelfth grades is a collection of innovative, water-related activities that are hands-on, easy to use, and fun. The activities incorporate a variety of formats such as large…

  20. Energy and Man's Environment: Activity Guide. An Interdisciplinary Teacher's Guide to Energy and Environmental Activities.

    ERIC Educational Resources Information Center

    Jones, John, Ed.

    This publication provides the goals, concepts, objectives, and rationale for the six activity guides in this series of energy education materials. The organization of this series, as presented in this publication, centers around six goals which correspond to the activity guides. Under each goal are several concepts, which in turn, have several…

  1. Community Service-Learning: A Guide to Including Service in the Public School Curriculum.

    ERIC Educational Resources Information Center

    Wade, Rahima C., Ed.

    This book provides a comprehensive guide to help educators in K-12 service learning programs. Each of the book's four parts provides a different scope and purpose. Part 1, "Community Service-Learning," addresses the components of quality service learning programs and includes the chapters (all written by Rahima C. Wade) : (1) "Community…

  2. Math Skills for Business. Instructor's Guide. Student Activity Packet. Office Occupations.

    ERIC Educational Resources Information Center

    Johnson, Diane E.

    This training package, one in a series of instructional modules consisting of an instructor's guide and a student activity packet, deals with math skills for business. Included in the instructor's guide are general directions for implementing the presentation; a detailed guide for teaching the lesson that includes performance objectives,…

  3. Managing the Office Employee. Instructor's Guide. Student Activity Packet. Office Occupations.

    ERIC Educational Resources Information Center

    Johnson, Diane E.

    This training package, one in a series of instructional modules consisting of an instructor's guide and a student activity packet, deals with managing the office employee. Included in the instructor's guide are general directions for implementing the presentation; a detailed guide for teaching the lesson that includes performance objectives,…

  4. Developing specialized guided worksheets for active learning in physics lectures

    NASA Astrophysics Data System (ADS)

    Sujarittham, T.; Emarat, N.; Arayathanitkul, K.; Sharma, M. D.; Johnston, I.; Tanamatayarat, J.

    2016-03-01

    As universities attempt to integrate active learning into their lectures, a range of strategies is emerging. Amongst the strategies is pre-prepared worksheets which students work through, facilitated by the lecturer. Despite the fact that worksheets have not yet been the subject of much research activity, there are instances of their use. Once such instance is by a pair of physics lecturers at Mahidol University, Thailand. The worksheets, called guided worksheets as they provide structure for students to take notes as the content in the lectures progresses, are prepared by the lecturers and have been in use since 2004. Evaluations showed that the guided worksheets met their intent but there were issues around certain topics which students found challenging. Concerted effort lead to the development of research based specialized guided worksheets for those topics that had issues. These specialized guided worksheets requiring substantially more interactions and student problem solving in line with active learning strategies, have been in use since 2012. This paper aims to describe the design of the specialized guided worksheets for the topic of electric field, and its evaluation. Pre- and post-tests were implemented over 2 years. The first was with guided worksheets with 260 students in 2011, and the second included specialized guided worksheets with 163 students in 2012. Gains on student understanding were higher in 2012 and students who were interviewed indicated that they found the specialized guided worksheets helpful for learning. The results indicate that the specialized guided worksheets made a difference in topics that students find challenging.

  5. Guide to Nonsexist Teaching Activities (K-12).

    ERIC Educational Resources Information Center

    Stone, Karen; And Others

    Designed to offset the effect of sexually biased texts and materials, this annotated bibliography lists available nonsexist instructional resource material for students in kindergarten through twelfth grades. The majority of items focus on activities teachers can use in classroom settings. The guide is organized into the following eight subject…

  6. Human Development Program: Level VI Activity Guide.

    ERIC Educational Resources Information Center

    Ball, Geraldine

    The curriculum guide presents the activities component of the Human Development Program for grade 6. The Human Development Program (HDP) is an affective curricular approach developed by psychologists to aid teachers in instilling responsibility and self-confidence in children. The nucleus of the Human Development Program is a circle session…

  7. Human Development Program: Level III Activity Guide.

    ERIC Educational Resources Information Center

    Bessell, Harold

    The curriculum guide presents the activities component of the Human Development Program for the third grade. The Human Development Program (HDP) is an affective curricular approach developed by psychologists to help teachers instill responsibility and self-confidence in children. Following a brief overview of the HDP and explanation of the Magic…

  8. Activated Sludge. Instructor's Guide. Biological Treatment Process Control.

    ERIC Educational Resources Information Center

    Boe, Owen K.

    This instructor's guide contains the materials needed to teach a seven-lesson unit on activated sludge. These materials include an overview of the unit, lesson plans, lecture outlines (keyed to slides designed for use with the lessons), student worksheets for each of the seven lessons (with answers), and two copies of a final quiz (with and…

  9. Made in USA: Project Ethnic Heritage: Activity and Discussion Guide.

    ERIC Educational Resources Information Center

    Smith, Gary R.

    The teaching guide suggests a variety of discussion and activity strategies relating to ethnicity for secondary and continuing education students. Objectives include helping people understand the nature and significance of their own heritage as well as that of each ethnic group, and encouraging participants to realize and deal with the impact…

  10. Microgravity: Teacher's Guide with Activities for Physical Science.

    ERIC Educational Resources Information Center

    Vogt, Gregory L.; Wargo, Michael J.

    This teacher's guide to microgravity contains 16 student science activities with full background information to facilitate an understanding of the concepts of microgravity for teachers and students. Topics covered in the background sections include the definitions of gravity and microgravity, creating microgravity, the fluid state, combustion…

  11. Project WET Curriculum and Activity Guide 2.0

    ERIC Educational Resources Information Center

    Project WET Foundation, 2011

    2011-01-01

    The "Project WET Curriculum and Activity Guide 2.0" continues Project WET's dedication to 21st-century, cutting-edge water education. Now in full color, Guide 2.0 offers new activities on topics such as National Parks and storm water, fully revised and updated activities from the original Guide and the very best activities gathered from all of…

  12. Education & Recycling: Educator's Waste Management Resource and Activity Guide 1994.

    ERIC Educational Resources Information Center

    California State Dept. of Conservation. Sacramento. Div. of Recycling.

    This activity guide for grades K-12 reinforces the concepts of recycling, reducing, and reusing through a series of youth-oriented activities. The guide incorporates a video-based activity, multiple session classroom activities, and activities requiring group participation and student conducted research. Constructivist learning theory was…

  13. Coping with Fears and Stress. An Activity Guide: Grades K-8.

    ERIC Educational Resources Information Center

    Robinson, Edward H.; And Others

    This guide consists of a set of activities to help elementary school students cope with fears and stress. Each activity includes the curricular areas in which it would fit (i.e., language arts, social studies, etc.), the grade level and group size for which it is suitable, and the approximate time necessary for its completion. The guide is divided…

  14. Design guide for predicting nonlinear random response (including snap-through) of buckled plates

    NASA Technical Reports Server (NTRS)

    Ng, Chung Fai

    1989-01-01

    This design guide describes a method for predicting the random response of flat and curved plates which is based on theoretical analyses and experimental results. The plate curvature can be due to postbuckling, in-plane mechanical or thermal stresses. Based on a single mode formula, root mean square values of the strain response to broadband excitation are evaluated for different static buckled configurations using the equivalent linearization technique. The effects on the overall strain response due to instability motion of snap-through are included. Panel parameters include clamped and simply-supported boundaries, aspect ratio, thickness and length. Analytical results are compared with experimental results from tests with 12 in. x 15 in. aluminum plates under thermal loading in a progressive wave facility. Comparisons are also made with results from tests with a 2 in. x 15 in. x 0.032 in. aluminum beam under base mechanical excitation. The comparisons help to assess the accuracy of the theory and the conditions under which deviations from the theory due to effects of imperfection and higher modes are significant.

  15. Workshop Physics Activity Guide, Module 4: Electricity and Magnetism

    NASA Astrophysics Data System (ADS)

    Laws, Priscilla W.

    2004-05-01

    The Workshop Physics Activity Guide is a set of student workbooks designed to serve as the foundation for a two-semester calculus-based introductory physics course. It consists of 28 units that interweave text materials with activities that include prediction, qualitative observation, explanation, equation derivation, mathematical modeling, quantitative experiments, and problem solving. Students use a powerful set of computer tools to record, display, and analyze data, as well as to develop mathematical models of physical phenomena. The design of many of the activities is based on the outcomes of physics education research. The Workshop Physics Activity Guide is supported by an Instructor's Website that: (1) describes the history and philosophy of the Workshop Physics Project; (2) provides advice on how to integrate the Guide into a variety of educational settings; (3) provides information on computer tools (hardware and software) and apparatus; and (4) includes suggested homework assignments for each unit. Log on to the Workshop Physics Project website at http://physics.dickinson.edu/ Workshop Physics is a component of the Physics Suite--a collection of materials created by a group of educational reformers known as the Activity Based Physics Group. The Physics Suite contains a broad array of curricular materials that are based on physics education research, including:

      Understanding Physics, by Cummings, Laws, Redish and Cooney (an introductory textbook based on the best-selling text by Halliday/Resnick/Walker) RealTime Physics Laboratory Modules Physics by Inquiry (intended for use in a workshop setting) Interactive Lecture Demonstration Tutorials in Introductory Physics Activity Based Tutorials (designed primarily for use in recitations)

    • Microgravity: a Teacher's Guide with Activities, Secondary Level

      NASA Technical Reports Server (NTRS)

      Vogt, Gregory L. (Editor); Wargo, Michael J. (Editor)

      1992-01-01

      This NASA Educational Publication is a teacher's guide that focuses on microgravity for the secondary level student. The introduction answers the question 'What is microgravity?', as well as describing gravity and creating microgravity. Following the introduction is a microgravity primer which covers such topics as the fluid state, combustion science, materials science, biotechnology, as well as microgravity and space flight. Seven different activities are described in the activities section and are written by authors prominent in the field. The concluding sections of the book include a glossary, microgravity references, and NASA educational resources.

    • Track and Field Guide including Cross Country, Pentathlon Scoring Tables and Rules for Intercollegiate Meets and Championships with Official Rules. Janauary 1974-January 1976.

      ERIC Educational Resources Information Center

      Thompson, Donnis H., Ed.

      This guide includes information on cross country running, pentathlon scoring tables, and rules for intercollegiate meets and championships, following an introductory portion on the organization's credo and standards. The first section covers track activities for children, coaching techniques, the benefits of weight training, and some practical…

    • RBDMS user`s guide which includes the RBDMS administrative guide, Version 4.0. Appendix A

      SciTech Connect

      1995-03-01

      RBDMS (Risk Based Data Management System) is an oil and gas electronic data management system which stems from the idea developed from four previous projects conducted by the American Petroleum Institute (API) and the Ground Water Protection Council (GWPC). The first study studied oil and gas industry injection well corrosion. It included a methodology for assessing the probability of contaminating underground sources of drinking water (USDWs) via Class 2 injection well operations. A feasibility study was conducted to investigate if an electronic data management system could incorporate the methodology. A second feasibility study was conducted to test the methodology on a much small basis. The RBDMS effort then continued through a grant from DOE with a multi-task project consisting of an inventory and needs assessment of 25 oil and gas producing states pertaining to oil and gas production/regulatory activities, state geological/hydrogeological considerations, Class 2 underground injection activities, electronic data management needs and functional requirements, environmental risk assessment and management objectives, resultant benefit of a RBDMS, and various information and data required for the design and development of a RBDMS in individual states. This appendix contains the documentation for the use of the RBDMS.

    • Everglades National Park Including Biscayne National Park. Activity Book.

      ERIC Educational Resources Information Center

      Ruehrwein, Dick

      Intended to help elementary school children learn about the resources of the Everglades and Biscayne National Parks, this activity book includes information, puzzles, games, and quizzes. The booklet deals with concepts related to: (1) the seasons; (2) fire ecology; (3) water; (4) fish; (5) mammals; (6) mosquitos; (7) birds; (8) venomous snakes;…

    • So What's It to Me? Sexual Assault Information for Guys: Activity Guide.

      ERIC Educational Resources Information Center

      Stringer, Gayle M.; Rants-Rodriguez, Deanna

      This document is a group leader activity guide to accompany a sexual assault prevention program focusing on information for male teenagers. Background information, large group activities, comments for small group leaders, extension activities, activity sheets, and transparency masters are included for 15 group activities. These topics are covered…

  1. How High Is It? An Educator's Guide with Activities Focused on Scale Models of Distances.

    ERIC Educational Resources Information Center

    Rosenberg, Carla B.; Rogers, Melissa J. B.

    This guide focuses on scale models of distances. Activities also incorporate mathematics but can be used in science and technology grades 5-8 classes. The content of the book is divided into three sections: (1) Introductory Activities; (2) Core Activities; and (3) Activity/Assessment. Activities include: (1) KWL Chart; (2) Ball and String…

  2. A Guided Inquiry Activity for Teaching Ligand Field Theory

    ERIC Educational Resources Information Center

    Johnson, Brian J.; Graham, Kate J.

    2015-01-01

    This paper will describe a guided inquiry activity for teaching ligand field theory. Previous research suggests the guided inquiry approach is highly effective for student learning. This activity familiarizes students with the key concepts of molecular orbital theory applied to coordination complexes. Students will learn to identify factors that…

  3. Human Development Program: Level IV Activity Guide, Revised 1976.

    ERIC Educational Resources Information Center

    Bessell, Harold; Ball, Geraldine

    The curriculum guide presents the activities component of the Human Development Program for grade four. The Human Development Program (HDP) is an affective curricular approach developed by psychologists to help teachers instill responsibility and self-confidence in children. The activity guide presents topics and directions for 180 sequential…

  4. A Curriculum Activities Guide to Watershed Investigations and Environmental Studies, Volume 6. Revised.

    ERIC Educational Resources Information Center

    Gail, Peter A.; And Others

    This curriculum activities guide provides the teacher with a model for a comprehensive program in watershed studies. With increased concern over water pollution, a study of the watershed is important to complete an understanding of water drainage problems. This guide includes a rationale for the study of watersheds and develops methods of…

  5. The Farkleberry Cookbook in Environmental Education. An Activity Guide for Creative Teachers.

    ERIC Educational Resources Information Center

    Fulton, William L., Ed.

    This interdisciplinary environmental education guide, developed by teachers, focuses on the creative teacher, presenting him/her an approach for involving all types of students in junior and senior high schools in activities which would cause them to evaluate values and give them an opportunity to express their own thoughts. The guide includes six…

  6. On Campus Activity Guide. Environmental Education.

    ERIC Educational Resources Information Center

    Pinellas County School Board, Clearwater, FL.

    Descriptions of about 100 secondary-level activities that can be done on the school grounds are presented. Among the lessons included are a study of life in sidewalk cracks, methods of estimating animal populations, soil testing, constructing and using triangulation instruments to map the school area, and creative writing exercises. Although most…

  7. Guide to Technical, Trade, & Business Schools, Including All Community Colleges, 1998-2000. Northeast Edition.

    ERIC Educational Resources Information Center

    Decker, Cory, Ed.

    This regional 1998-2000 guide (one of four--Northeast, Southeast, Midwest, and West) lists community colleges and technical, trade, and business schools in the Northeast United States. School listings are arranged alphabetically by state, and within each state, alphabetically by the school's name. At the end of the volume is a regional index…

  8. Guide to Technical, Trade, & Business Schools, Including All Community Colleges, 1998-2000. West Edition.

    ERIC Educational Resources Information Center

    Decker, Cory, Ed.

    This regional 1998-2000 guide (one of four--Northeast, Southeast, Midwest, and West) lists community colleges and technical, trade, and business schools in the Western United States. School listings are arranged alphabetically by state, and within each state, alphabetically by the school's name. At the end of each volume is a regional index…

  9. Guide to Technical, Trade, & Business Schools, Including All Community Colleges, 1998-2000. Southeast Edition.

    ERIC Educational Resources Information Center

    Decker, Corey, Ed.

    This regional 1998-2000 guide (one of four--Northeast, Southeast, Midwest, and West) lists community colleges and technical, trade, and business schools in the Southeast United States. School listings are arranged alphabetically by state, and within each state, alphabetically by the school's name. At the end of each volume is a regional index…

  10. Plate-guided distraction osteogenesis to recreate two-thirds of the mandible including symphysis.

    PubMed

    Mohammed-Ali, Ricardo I; Henry, Alastair M; Khurram, Syed A; Yousefpour, Afshin

    2012-12-01

    We report a case of plate-guided distraction osteogenesis to reconstruct a large mandibular defect caused by recurrence of an ameloblastoma in a 17-year-old male patient who had previously had reconstruction using a fibula bone graft. PMID:22726522

  11. A Teacher's Guide to Including Students with Disabilities in General Physical Education, Third Edition

    ERIC Educational Resources Information Center

    Block, Martin E.

    2007-01-01

    This book, provides a comprehensive guide to making phys. ed. inclusion work for students of all ages. In this new edition of the trusted bestseller, renowned expert Martin E. Block and a select group of highly respected contributors provide: (1) new information reflecting all the latest updates to IDEA, other disability-related legislation, and…

  12. A Teacher's Guide to Including Students with Disabilities in Regular Physical Education.

    ERIC Educational Resources Information Center

    Block, Martin E.

    This guide provides guidance on the inclusion of students with disabilities in regular physical education classes. Section 1 comprises three chapters which focus on philosophy, beliefs, and attitudes in relation to physical education, inclusion, and team assessment and programming. The development of a collaborative Physical Education Inclusion…

  13. Rivers at Risk: An Activity Based Study Guide for the Colorado River Basin.

    ERIC Educational Resources Information Center

    Samples, Bob, Ed.

    This activity guide is intended to increase student awareness and understanding about the Colorado River Basin. Each activity includes objectives, procedures, materials list, related activities, questions for students, and related information. The activities are varied to appeal to a wide range of learning styles and modalities and are…

  14. A Social Studies Activities Guide for Students in Special Education.

    ERIC Educational Resources Information Center

    New York City Board of Education, Brooklyn, NY. Div. of Special Education.

    The guide uses an activities-based approach to reinforce both social studies content and skills for special education elementary students. The guide has been designed to correspond with the scope and sequence of New York City's Minimum Teaching Essentials. Six themes are examined: (1) developing individuality and a sense of self (social/emotional…

  15. Economics and Entrepreneurship: Student Activities. Master Curriculum Guide.

    ERIC Educational Resources Information Center

    National Council on Economic Education, New York, NY.

    Correlated to the Economics and Entrepreneurship Teaching Strategies Master Curriculum Guide, this book features 66 student activities, case studies, comprehension quizzes, and lessons related to economic concepts. Designed for high school students of economics, social studies, and business education, this curriculum guide combines study of basic…

  16. Space-Based Astronomy: A Teacher's Guide with Activities.

    ERIC Educational Resources Information Center

    National Aeronautics and Space Administration, Washington, DC.

    This curriculum guide uses hands-on activities to help grade 5-8 students and teachers understand the significance of space-based astronomy--astronomical observations made from outside the Earth's atmosphere. The guide begins with a survey of astronomy-related spacecraft that the National Aeronautics and Space Administration (NASA) has sent into…

  17. NASTRAN thermal analyzer: Theory and application including a guide to modeling engineering problems, volume 2. [sample problem library guide

    NASA Technical Reports Server (NTRS)

    Jackson, C. E., Jr.

    1977-01-01

    A sample problem library containing 20 problems covering most facets of Nastran Thermal Analyzer modeling is presented. Areas discussed include radiative interchange, arbitrary nonlinear loads, transient temperature and steady-state structural plots, temperature-dependent conductivities, simulated multi-layer insulation, and constraint techniques. The use of the major control options and important DMAP alters is demonstrated.

  18. Essential Laboratory Activities Guide. Secondary Science.

    ERIC Educational Resources Information Center

    Duval County Schools, Jacksonville, FL.

    This teacher's guide was developed for use in junior and senior high schools in Duval County, Jacksonville, Florida, for the purpose of identifying those secondary science laboratory experiences which are essential to the development of science content knowledge and competency in handling science laboratory equipment and consumables. The guide…

  19. Career Pathways Skill-Building Activities Guide.

    ERIC Educational Resources Information Center

    Community Coll. of Rhode Island, Warwick.

    In an effort to relate academic skills with workplace skills and facilitate the transition from school to work, the Community College of Rhode Island developed a skill-based instructional model targeted at 9th through 12th graders and consisting of 6 instructional areas, or strands, and 31 related skills. This guide provides suggested activities…

  20. Rockets: Physical Science Teacher's Guide with Activities.

    ERIC Educational Resources Information Center

    Vogt, Gregory L.; Rosenberg, Carla R., Ed.

    Rockets have evolved from simple tubes filled with black powder into mighty vehicles capable of launching a spacecraft out into the galaxy. The guide begins with background information sections on the history of rocketry, scientific principles, and practical rocketry. The sections on scientific principles and practical rocketry are based on Isaac…

  1. Classroom Archaeology: An Archaeology Activity Guide for Teachers. Third Edition.

    ERIC Educational Resources Information Center

    Hawkins, Nancy W.

    This guide describes archaeology activities appropriate for middle school students, but some activities can be used in intermediate and primary grades or high school and college classes. The activities range in length from less than one hour to 15 hours. A sequence of activities may be used together as a unit on archaeology, or individual…

  2. A Curriculum Activities Guide to Water Pollution and Environmental Studies.

    ERIC Educational Resources Information Center

    Hershey, John T.; And Others

    This activity oriented environmental guide is the result of cooperative efforts of high school teachers, students, scientists, and technicians. The activities are divided into four chapters: Hydrologic Cycle; Human Activities; Ecological Perspectives; and Social and Political Factors. Each activity contains seven parts: an introduction; questions…

  3. Adventures in Peacemaking: A Conflict Resolution Activity Guide for School-Age Programs.

    ERIC Educational Resources Information Center

    Kreidler, William J.; Furlong, Lisa

    This guide includes hundreds of hands-on, engaging activities designed to meet the unique needs of after-school programs, camps, and recreation centers. The activities teach the skills of creative conflict resolution to school-age children through games, cooperative team challenges, drama, crafts, music, and cooking. It includes easy-to-implement…

  4. Litter Control Achievement - Ohio 4-H Club Score Sheet [and] Activity Guides 1 through 7. 4-H Pilot Program 918.

    ERIC Educational Resources Information Center

    Ohio State Univ., Columbus. Cooperative Extension Service.

    Seven activity guides, evaluation sheet, and club scoresheet have been prepared for Ohio 4-H clubs' litter education program. Topics of the seven activity guides include: (1) general guidelines and types of activities; (2) little known facts about waste/litter; (3) guidelines for a walking tour; (4) fact sheet (questionnaire) related to garbage;…

  5. Guide to good practices for line and training manager activities

    SciTech Connect

    1998-06-01

    The purpose of this guide is to provide direction for line and training managers in carrying out their responsibilities for training and qualifying personnel and to verify that existing training activities are effective.

  6. Brain in Space: A Teacher's Guide with Activities for Neuroscience

    NASA Technical Reports Server (NTRS)

    Sullivan, Walter W., Jr.

    1998-01-01

    The lessons and activities in this guide will engage your students in the excitement of space life science investigations after the Neurolab Spacelab mission. It is the authors' goal that the information in this guide will inspire both you and your students to become interested and active participants in this space mission. Few experiences can compare with the excitement and thrill of watching a Shuttle launch. This guide provides an opportunity for you and your students to go one step further by conducting the experiments on Earth that are relevent to the research conducted in space.

  7. Energy and Man's Environment Activity Guide: An Interdisciplinary Teacher's Guide to Energy and Environmental Activities, Section Three - Conversion of Energy.

    ERIC Educational Resources Information Center

    Jones, John, Ed.

    This publication presents the activities pertaining to the third goal of this activity guide series. The activities in this publication focus on understanding conservation processes, efficiencies, socioeconomic costs, and personal decision-making. These materials are appropriate for middle school and junior high school students. These activities,…

  8. Microgravity: Teacher's guide with activities for physical science

    NASA Technical Reports Server (NTRS)

    Vogt, Gregory L.; Wargo, Michael J.; Rosenberg, Carla B. (Editor)

    1995-01-01

    This guide is an educational tool for teachers of grades 5 through 12. It is an introduction to microgravity and its application to spaceborne laboratory experiments. Specific payloads and missions are mentioned with limited detail, including Spacelab, the International Microgravity Laboratory, and the United States Microgravity Laboratory. Activities for students demonstrate chemistry, mathematics, and physics applications of microgravity. Activity objectives include: modeling how satellites orbit Earth; demonstrating that free fall eliminates the local effects of gravity; measuring the acceleration environments created by different motions; using a plasma sheet to observe acceleration forces that are experienced on board a space vehicle; demonstrating how mass can be measured in microgravity; feeling how inertia affects acceleration; observing the gravity-driven fluid flow that is caused by differences in solution density; studying surface tension and the fluid flows caused by differences in surface tension; illustrating the effects of gravity on the burning rate of candles; observing candle flame properties in free fall; measuring the contact angle of a fluid; illustrating the effects of gravity and surface tension on fiber pulling; observing crystal growth phenomena in a 1-g environment; investigating temperature effects on crystal growth; and observing crystal nucleation and growth rate during directional solidification. Each activity includes a background section, procedure, and follow-up questions.

  9. Do You Read Me? Industrial Supplement: Reading Development Activities Guide.

    ERIC Educational Resources Information Center

    Kendall, Elizabeth L.; Chenoweth, Roberta

    This activity guide is one of four supplements to be used with "Do You Read Me? Prevocational-Vocational Reading Development Activities" (ED 210 454). Each supplement deals with a different occupational category. Games, puzzles, and other activities are offered to aid in developing the word recognition, vocabulary, and comprehension skills of…

  10. Agricultural Science Lab Activities. Instructor Guide. Volume 27, Number 2.

    ERIC Educational Resources Information Center

    Thompson, Gregory W.; And Others

    This instructor guide contains 20 laboratory activities for grades 9-10 Agricultural Science I-II classes. The activities are cross-referenced to Missouri Core Competencies and Key Skills. The activities are organized into the following areas: introductory (microscope use); animal nutrition (absorption of nutrients, bacteria and disease, enzyme…

  11. Intentional Development: A Model to Guide Lifelong Physical Activity

    ERIC Educational Resources Information Center

    Cherubini, Jeffrey M.

    2009-01-01

    Framed in the context of researching influences on physical activity and actually working with individuals and groups seeking to initiate, increase or maintain physical activity, the purpose of this review is to present the model of Intentional Development as a multi-theoretical approach to guide research and applied work in physical activity.…

  12. Teacher's Activity Guide to Coastal Awareness. Marine Bulletin No. 23.

    ERIC Educational Resources Information Center

    Callaghan, Sara S.

    This teacher's guide was prepared for use with "Down Where the Water Is: A Coastal Awareness Activity Book," as part of the Rhode Island Coastal Resources Management Council's public education program. Contained are instructions on the use of the Activity Book, page-by-page, with glossaries, activity ideas, resources, places to visit, and notes…

  13. Project WILD K-12 Curriculum and Activity Guide

    ERIC Educational Resources Information Center

    Council for Environmental Education, 2011

    2011-01-01

    The "Project WILD K-12 Curriculum and Activity Guide" focuses on wildlife and habitat. It is organized in topic units and is based on the Project WILD conceptual framework. Because these activities are designed for integration into existing courses of study, instructors may use one or many Project WILD activities or the entire set of activities…

  14. Do You Read Me? Service Supplement: Reading Development Activities Guide.

    ERIC Educational Resources Information Center

    Kendall, Elizabeth L.; Chenoweth, Roberta

    This activity guide is one of four supplements to be used with "Do You Read Me? Prevocational-Vocational Reading Development Activities" (ED 210 454). Each supplement deals with a different occupational category. Games, puzzles, and other activities are offered to aid in developing the word recognition, vocabulary, and comprehension skills of…

  15. Do You Read Me? Environmental Supplement: Reading Development Activities Guide.

    ERIC Educational Resources Information Center

    Kendall, Elizabeth L.; Chenoweth, Roberta

    This activity guide is one of four supplements to be used with "Do You Read Me? Prevocational-Vocational Reading Development Activities" (ED 210 454). Each supplement deals with a different occupational category. Games, puzzles, and other activities are offered to aid in developing the word recognition, vocabulary, and comprehension skills of…

  16. Energy and Man's Environment Activity Guide: An Interdisciplinary Teacher's Guide to Energy and Environmental Activities, Section Four - Impacts of Energy.

    ERIC Educational Resources Information Center

    Jones, John, Ed.

    This publication presents the activities pertaining to the fourth goal of this activity guide series. The activities in this publication focus on the socioeconomic effects of energy uses and crises and the understandings needed to assess those effects. These materials are appropriate for middle school and junior high school students. These…

  17. Energy and Man's Environment Activity Guide: An Interdisciplinary Teacher's Guide to Energy and Environmental Activities, Section One - Sources of Energy.

    ERIC Educational Resources Information Center

    Jones, John, Ed.

    This publication presents the activities pertaining to the first goal of this activity guide series. The activities in this publication focus primarily on the availability of resources, forms of energy, natural laws, and socioeconomic considerations. These materials are appropriate for middle school and junior high school students. These…

  18. Vibration and Instability of Plate-Assemblies including Shear and Anisotropy (VIPASA) user's guide, addendum

    NASA Technical Reports Server (NTRS)

    Anderson, M. S.; Hennessy, K. W.; Heard, W. L., Jr.

    1976-01-01

    Extensions developed at Langley Research Center to the VIPASA computer program are described including a procedure for simple thermal stress analysis and options for graphical display of output. Input requirements for operation of the modified program are given in detail.

  19. Do government brochures affect physical activity cognition? A pilot study of Canada's physical activity guide to healthy active living.

    PubMed

    Kliman, Aviva M; Rhodes, Ryan

    2008-08-01

    Health Canada has published national physical activity (PA) guidelines, which are included in their 26-page Physical Activity Guide to Healthy Active Living (CPAG). To date, the use of CPAG as a motivational instrument for PA promotion has not been evaluated. The purpose of this study was to determine whether reading CPAG 1) increased motivational antecedents to engage in regular PA, and 2) increased regular PA intention and behaviour over 1 month. Participants included 130 randomly sampled Canadian adults (18 years or older) who were randomly mailed pack ages consisting of either 1) a questionnaire and a copy of CPAG, or 2) a questionnaire. Questionnaire items pertained to participants' sociodemographics, previous PA behaviours (Godin Leisure-Time Questionnaire) and PA motivation (theory of planned behaviour). Participants were then sent a follow-up questionnaire pertaining to their PA behaviours throughout the previous month. Results revealed significant interactions between the guide condition and previous activity status on instrumental behavioural beliefs about strength activities and subjective norms about endurance activities (p < 0.05), but all other factors were not significantly different. It was concluded that among previously inactive people, receiving this guide may change some informational/motivational constructs, but key motivational antecedents (affective attitude, perceived behavioural control) and outcomes (intention, behaviour) seem unaffected. PMID:18825580

  20. Measuring and Reducing Off-Target Activities of Programmable Nucleases Including CRISPR-Cas9.

    PubMed

    Koo, Taeyoung; Lee, Jungjoon; Kim, Jin-Soo

    2015-06-01

    Programmable nucleases, which include zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and RNA-guided engineered nucleases (RGENs) repurposed from the type II clustered, regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (Cas9) system are now widely used for genome editing in higher eukaryotic cells and whole organisms, revolutionising almost every discipline in biological research, medicine, and biotechnology. All of these nucleases, however, induce off-target mutations at sites homologous in sequence with on-target sites, limiting their utility in many applications including gene or cell therapy. In this review, we compare methods for detecting nuclease off-target mutations. We also review methods for profiling genome-wide off-target effects and discuss how to reduce or avoid off-target mutations. PMID:25985872

  1. Evaluating Metacognitive Scaffolding in Guided Invention Activities

    ERIC Educational Resources Information Center

    Roll, Ido; Holmes, Natasha G.; Day, James; Bonn, Doug

    2012-01-01

    Invention and Productive Failure activities ask students to generate methods that capture the important properties of some given data (e.g., uncertainty) before being taught the expert solution. Invention and Productive Failure activities are a class of scientific inquiry activities in that students create, implement, and evaluate mathematical…

  2. The Brain in Space: A Teacher's Guide with Activities for Neuroscience.

    ERIC Educational Resources Information Center

    MacLeish, Marlene Y.; McLean, Bernice R.

    This educators guide discusses the brain and contains activities on neuroscience. Activities include: (1) "The Space Life Sciences"; (2) "Space Neuroscience: A Special Area within the Space Life Sciences"; (3) "Space Life Sciences Research"; (4) "Neurolab: A Special Space Mission to Study the Nervous System"; (5) "The Nervous System"; (6)…

  3. Planetary Geology: A Teacher's Guide with Activities in Physical and Earth Sciences.

    ERIC Educational Resources Information Center

    National Aeronautics and Space Administration, Washington, DC.

    This educator's guide discusses planetary geology. Exercises are grouped into five units: (1) introduction to geologic processes; (2) impact cratering activities; (3) planetary atmospheres; (4) planetary surfaces; and (5) geologic mapping. Suggested introductory exercises are noted at the beginning of each exercise. Each activity includes an…

  4. Recycle Alaska: Reduce, Reuse, Recycle. Activities Handbook, Teacher's Guide, and Student Worksheets.

    ERIC Educational Resources Information Center

    Alaska State Dept. of Education, Juneau.

    Recycling is a very important aspect of conserving the environment for future generations. This guide addresses the topic of litter prevention for the Alaskan environment and contains 42 activities. Activity topics covered include Natural Cycles, Human Interruption of Natural Cycles, Reduce, Reuse, Recycle and Recycled Classroom. Grade level,…

  5. Curriculum Resources for Environmental Progress, Vol. 1: Curriculum Outline and Activities Guide.

    ERIC Educational Resources Information Center

    Kalamazoo Nature Center, Inc., MI.

    This publication is the first volume of curriculum resources published by the Kalamazoo Nature Center. It contains directions for using the curriculum activities guide and suggests ways of implementing the activities in the classroom. Also included is an outline of the material that could be covered in an environmental education program, with…

  6. Off to Adventure: 24 Guided Activities for K-3 Children.

    ERIC Educational Resources Information Center

    Knothe, Carol; Lang, Karen; Lange, Pauline; Most, JoAnn; Palmer, Terry; Sorte, Joanne

    This book contains 24 guided environmental education activities for K-3 children that offer young children opportunities to explore and learn about their world in a positive environment. The activities encourage the children to gain confidence and develop a positive self-image; develop important life skills; learn about science, literature, and…

  7. Illinois State Bar Association Law Day Activities Guide. 2001 Edition.

    ERIC Educational Resources Information Center

    Illinois State Bar Association, Springfield.

    These law-related lessons and activities can facilitate participation in a Law Day program. Following an introduction, this activities guide is divided into these sections: "Tips for Teachers" ("What Can a Lawyer Add to the Classroom?"; "So You Have Been Asked to Speak to Kids about the Law"; "A Checklist for Lawyers and Judges in the Classroom");…

  8. Project WILD Aquatic K-12 Curriculum and Activity Guide

    ERIC Educational Resources Information Center

    Council for Environmental Education, 2011

    2011-01-01

    The "Project WILD Aquatic K-12 Curriculum and Activity Guide" emphasizes aquatic wildlife and aquatic ecosystems. It is organized in topic units and is based on the Project WILD conceptual framework. Because these activities are designed for integration into existing courses of study, instructors may use one or many Project WILD Aquatic activities…

  9. Career Motivation Activities Guide, 4th through 6th Grade.

    ERIC Educational Resources Information Center

    Toledo Public Schools, OH.

    The activities guide is intended primarily to assist teachers in grades 4-7 in teaching career awareness concepts. Instructional activities correlate basic skill and career education objectives. The 29 units cover topics related to social studies (self-awareness, the community, the school, transportation, the environment, family roles, economic…

  10. Kanienkehaka Tiontenientenstakwa [Mohawk Guide Book]. Activities and Games.

    ERIC Educational Resources Information Center

    Steele, Catherine; And Others

    This collection of activities and games is a supplement to "The Language Guide for Elementary Mohawk." These activities and games provide additional classroom practice for the topical language components in the companion book. The vocabulary encompasses names, singular commands, colors, numbers, foods, animals, clothing, household, money, seasons,…

  11. Growing Together with the Treetures. Activity Guide. Series 1.

    ERIC Educational Resources Information Center

    Schnell, Bobbi; Blau, Judith H.; Hinrichs, Jennifer Judd

    This activity guide is designed to be used with the Growing Together program. Tree-related activities are correlated to the Benchmarks for Scientific Literacy, the recommended standards for mathematics, science, and technology suggested by the American Association for the Advancement of Science (AAAS). The Treature Educational Program is dedicated…

  12. Teacher's Guide to Aviation Education Resources. Including: Career Information, Audiovisuals, Publications, Periodicals.

    ERIC Educational Resources Information Center

    Federal Aviation Administration (DOT), Washington, DC. Office of Public Affairs.

    Currently available aviation education resource materials are listed alphabetically by title under four headings: (1) career information; (2) audiovisual materials; (3) publications; and (4) periodicals. Each entry includes: title; format (16mm film, slides, slide/tape presentation, VHS/Beta videotape, book, booklet, newsletter, pamphlet, poster,…

  13. Pilot's Guide to an Airline Career, Including Sample Pre-Employment Tests.

    ERIC Educational Resources Information Center

    Traylor, W.L.

    Occupational information for persons considering a career as an airline pilot includes a detailed description of the pilot's duties and material concerning preparation for occupational entry and determining the relative merits of available jobs. The book consists of four parts: Part I, The Job, provides an overview of a pilot's duties in his daily…

  14. Spacecraft materials guide. [including: encapsulants and conformal coatings; optical materials; lubrication; and, bonding and joining processes

    NASA Technical Reports Server (NTRS)

    Staugaitis, C. L. (Editor)

    1975-01-01

    Materials which have demonstrated their suitability for space application are summarized. Common, recurring problems in encapsulants and conformal coatings, optical materials, lubrication, and bonding and joining are noted. The subjects discussed include: low density and syntactic foams, electrical encapsulants; optical glasses, interference filter, mirrors; oils, greases, lamillar lubricants; and, soldering and brazing processes.

  15. Suited for spacewalking: A teacher's guide with activities

    NASA Technical Reports Server (NTRS)

    Vogt, Gregory L. (Editor); Manning, Cheryl A. (Editor)

    1992-01-01

    This publication is an activity guide for teachers on spacesuits and spacewalking. It uses the intensive interest many children have in space exploration as a launching point for hands-on-opportunities. The guide begins with brief discussions of the space environment, the history of space walking, the Space Shuttle spacesuit, and working in space. These are followed by a series of activities that enable children to explore the space environment as well as the science and technology behind the functions of spacesuits. The activities are not rated for specific grade levels because they can be adapted for students of many ages. The guide concludes with a brief glossary as well as references and resources.

  16. Activity Guide for Career Education. Middle.

    ERIC Educational Resources Information Center

    Festus School District R-6, MO.

    The suggestions for learning activities in career education at the middle level (Grades 6-7) are presented with the aim of establishing career awareness related to five occupational clusters: environmental control, manufacturing, business office, fine arts and humanities, and marine science. The activities are presented under the headings of four…

  17. Wise Water Ways. Teaching Guide. Activity Book.

    ERIC Educational Resources Information Center

    Crites, Alice; And Others

    To increase student's awareness of the need to conserve water and ways they can become personally involved in developing water-saving habits, a water conservation education program was established. The program described contains a series of activities to be presented in the form of discussions, games, and puzzles. Each activity involves the…

  18. Getting Acquainted: An Induction Training Guide for First-Year Extension Agents. Suggestions for Completing Certain Learning Experiences Included in the Induction Training Guide; a Supplement to "Getting Acquainted."

    ERIC Educational Resources Information Center

    Collings, Mary Louise; Gassie, Edward W.

    An induction guide to help the extension agent get acquainted with his role and suggestions for completing learning experiences that are included in the guide comprise this two-part publication. The training guide learning experiences, a total of 25, are made up of: Objectives of the New Worker; When Completed; Learning Experiences; Person(s)…

  19. Including Microbial Acclimation in Carbon Cycle Models: Letting Data Guide Model Development (Invited)

    NASA Astrophysics Data System (ADS)

    Mayes, M. A.; Wang, G.; Tang, G.; Xu, X.; Jagadamma, S.

    2013-12-01

    Carbon cycle models are traditionally parameterized with ad hoc soil pools, empirical decay constants and first-order decomposition as a function of substrate supply. Decomposition of vegetative and faunal inputs, however, involves enzymatically-facilitated depolymerization by the microbial community. Traditional soil models are calibrated to match existing distribution of soil carbon, but they are not parameterized to predict the response of soil carbon to climate change due to microbial community shifts or physiological changes, i.e., acclimation. As an example, we will show how the temperature sensitivity of carbon use efficiency can influence the decomposition of different substrates and affect the release of CO2 from soil organic matter. Acclimation to warmer conditions could also involve shifts in microbial community composition or function, e.g., fungi: bacteria ratio shift. Experimental data is needed to decide how to parameterize models to accommodate functional or compositional changes. We will explore documented cases of microbial acclimation to warming, discuss methods to include microbial acclimation in carbon cycle models, and explore the need for additional experimental data to validate the next generation of microbially-facilitated carbon cycle models.

  20. The American Indian Social Studies Curriculum Activity Guide, Grades 7-8.

    ERIC Educational Resources Information Center

    Stutzman, Esther

    An attempt to add substance to history, the curriculum guide for grades 7-8 presents in 12 culture guides information on American Indians for teachers to use as supplement materials to social studies texts. Each culture guide is accompanied with a teacher guide offering activities or discussion/quiz questions. Topics of culture guides encompass…

  1. Ripples: A Big Sweep Elementary Activity Guide.

    ERIC Educational Resources Information Center

    Burgess, Carla B., Ed.

    Littering is a careless act indicating lack of respect for the environment, other people, and wildlife. Through education people can learn the consequences of littering and how to stop doing it. This book, designed for elementary children, presents a collection of 16 activities, ideas and resources concerning litter in the aquatic and marine…

  2. Branching Out: The North Carolina Forest Stewardship Activity Guide.

    ERIC Educational Resources Information Center

    Chesson, Gail

    Stewardship is the responsibility of individuals to maintain and improve their natural resources and surroundings. The Forest Stewardship Program (FSP) in North Carolina aims at enhancing the management of all forest resources on private lands. This activity guide is designed to help youth appreciate and understand forests and natural…

  3. A Curriculum Activities Guide to In-Depth Environmental Studies.

    ERIC Educational Resources Information Center

    Hershey, John T., Ed.; And Others

    This guide is the fourth in a series of four books emphasizing student-oriented problem solving related to environmental matters. It utilizes a three-level activity approach: awareness, transitional, and operational. The intent is to provide investigations that will motivate students to pursue in-depth studies, thus encouraging them to generate…

  4. Nutrition Activities Guide for Students in Special Education: Citywide Programs.

    ERIC Educational Resources Information Center

    New York City Board of Education, Brooklyn, NY. Div. of Special Education.

    The guide is designed to provide special education students with nutrition education in terms of daily living skills. Activities are organized according to five themes: what we eat (awareness of the physical and sensory characteristics of food, identification of food eaten at various meals); how we eat (identification of cutlery, manners, use of…

  5. Atmospheric Detectives. Atlas 2 Teacher's Guide with Activities.

    ERIC Educational Resources Information Center

    National Aeronautics and Space Administration, Washington, DC. Educational Affairs Div.

    As part of the National Aeronautics and Space Administration Mission to Planet Earth, ATLAS 2 will help develop a thorough picture of the Sun's output, its interaction with the atmosphere, and the well-being of Earth's middle atmosphere. This middle school level guide probes the connection between the activities of scientists and the observable…

  6. Community Guide to Evaluating Aboriginal Healing Foundation Activity.

    ERIC Educational Resources Information Center

    Aboriginal Healing Foundation, Ottawa (Ontario).

    The Aboriginal Healing Foundation (AHF), based in Ottawa (Ontario), works with Canada Native communities to reduce incidents of physical and sexual abuse, children in care, suicide, and incarceration among residential school survivors and their families. This guide has been prepared to help communities evaluate their AHF-funded activities in the…

  7. Teacher's Resource Guide on Acidic Precipitation with Laboratory Activities.

    ERIC Educational Resources Information Center

    Barrow, Lloyd H.

    The purpose of this teacher's resource guide is to help science teachers incorporate the topic of acidic precipitation into their curricula. A survey of recent junior high school science textbooks found a maximum of one paragraph devoted to the subject; in addition, none of these books had any related laboratory activities. It was on the basis of…

  8. Thinking Science: Classroom Activities in Secondary Science. Teacher's Guide.

    ERIC Educational Resources Information Center

    Adey, Philip; And Others

    This teacher's guide is part of a program of activities that help secondary-level students develop the complex thinking skills needed to succeed in science. This program can be used with current curriculum materials. It is designed to help students integrate ideas and develop concepts that demonstrate higher level thinking. A rich environment of…

  9. MRI-Guided Vascular Access with an Active Visualization Needle

    PubMed Central

    Saikus, Christina E.; Ratnayaka, Kanishka; Barbash, Israel M.; Colyer, Jessica H.; Kocaturk, Ozgur; Faranesh, Anthony Z.; Lederman, Robert J.

    2011-01-01

    Purpose To develop an approach to vascular access under MRI, as a component of comprehensive MRI-guided cardiovascular catheterization and intervention. Materials and Methods We attempted jugular vein access in healthy pigs as a model of “difficult” vascular access. Procedures were performed under real-time MRI guidance using reduced field of view imaging. We developed an “active” MRI antenna-needle having an open-lumen, distinct tip appearance and indicators of depth and trajectory, in order to enhance MRI visibility during the procedure. We compared performance of the active needle against an unmodified commercial passively-visualized needle, measured by procedure success among operators with different levels of experience. Results MRI-guided central vein access was feasible using both the active needle and the unmodified passive needle. The active needle required less time (88 vs. 244 sec, p=0.022) and fewer needle passes (4.5 vs. 9.1, p=0.028), irrespective of operator experience. Conclusion MRI-guided access to central veins is feasible in our animal model. When image guidance is necessary for vascular access, performing this component under MRI will allow wholly MRI-guided catheterization procedures that do not require adjunctive imaging facilities such as X-ray or ultrasound. The active needle design showed enhanced visibility, as expected. These capabilities may permit more complex catheter-based cardiovascular interventional procedures enabled by enhanced image guidance. PMID:22006552

  10. Activity Guide for Nutrition Education, Grades K-3.

    ERIC Educational Resources Information Center

    Chula Vista City School District, CA.

    This activity guide for foods and nutrition education at the primary level is divided into two sections: lesson plans and resource materials. Five concepts are outlined in the lesson plan: food choices, factors influencing choices, consumer competencies, food related careers, and food protection. Each lesson plan provides information on…

  11. Ecosystem Matters: Activity and Resource Guide for Environmental Educators.

    ERIC Educational Resources Information Center

    Adams, Mary; And Others

    An ecological approach involved making conscious decisions which result in actions that responsibly contribute to the long-term stewardship of natural resources. This activity and resource guide was designed for use by both educators and resource managers to supplement existing courses and programs concerning ecological matters. These…

  12. Forestry Activities. A Guide for Youth Group Leaders.

    ERIC Educational Resources Information Center

    Forest Service (USDA), Washington, DC.

    Twenty-six activities related to forestry, conservation, and outdoor education comprise the content of this leader's guide. Designed for use with youth groups, ideas and techniques range from forest conservation mobiles, locating forest fires, and Christmas tree uses to litterbug campaigns, watershed experiments, and crossword puzzles. Activities…

  13. Energy Conservation Activity Guide, Grades 9-12. Bulletin 1602.

    ERIC Educational Resources Information Center

    Fraser, Mollie; And Others

    As an interdisciplinary, non-sequential teaching guide, this publication was developed to increase awareness and understanding of the energy situation and to encourage individuals to become energy conservationists. Sections provide background information for the teacher followed by a variety of student activities using different subject areas for…

  14. Sports Medicine. Instructor's Guide, Student's Manual, Student Learning Activities.

    ERIC Educational Resources Information Center

    Fair, Helena J.

    The instructor's guide, the first of three documents in this package, is for a course designed for students investigating the activities within the sports medicine department or considering any of the areas of kinesiology as a career. The material is designed for individualized study and is competency based with educational outcomes stated for…

  15. Heat dissipation guides activation in signaling proteins

    PubMed Central

    Weber, Jeffrey K.; Shukla, Diwakar; Pande, Vijay S.

    2015-01-01

    Life is fundamentally a nonequilibrium phenomenon. At the expense of dissipated energy, living things perform irreversible processes that allow them to propagate and reproduce. Within cells, evolution has designed nanoscale machines to do meaningful work with energy harnessed from a continuous flux of heat and particles. As dictated by the Second Law of Thermodynamics and its fluctuation theorem corollaries, irreversibility in nonequilibrium processes can be quantified in terms of how much entropy such dynamics produce. In this work, we seek to address a fundamental question linking biology and nonequilibrium physics: can the evolved dissipative pathways that facilitate biomolecular function be identified by their extent of entropy production in general relaxation processes? We here synthesize massive molecular dynamics simulations, Markov state models (MSMs), and nonequilibrium statistical mechanical theory to probe dissipation in two key classes of signaling proteins: kinases and G-protein–coupled receptors (GPCRs). Applying machinery from large deviation theory, we use MSMs constructed from protein simulations to generate dynamics conforming to positive levels of entropy production. We note the emergence of an array of peaks in the dynamical response (transient analogs of phase transitions) that draw the proteins between distinct levels of dissipation, and we see that the binding of ATP and agonist molecules modifies the observed dissipative landscapes. Overall, we find that dissipation is tightly coupled to activation in these signaling systems: dominant entropy-producing trajectories become localized near important barriers along known biological activation pathways. We go on to classify an array of equilibrium and nonequilibrium molecular switches that harmonize to promote functional dynamics. PMID:26240354

  16. Heat dissipation guides activation in signaling proteins.

    PubMed

    Weber, Jeffrey K; Shukla, Diwakar; Pande, Vijay S

    2015-08-18

    Life is fundamentally a nonequilibrium phenomenon. At the expense of dissipated energy, living things perform irreversible processes that allow them to propagate and reproduce. Within cells, evolution has designed nanoscale machines to do meaningful work with energy harnessed from a continuous flux of heat and particles. As dictated by the Second Law of Thermodynamics and its fluctuation theorem corollaries, irreversibility in nonequilibrium processes can be quantified in terms of how much entropy such dynamics produce. In this work, we seek to address a fundamental question linking biology and nonequilibrium physics: can the evolved dissipative pathways that facilitate biomolecular function be identified by their extent of entropy production in general relaxation processes? We here synthesize massive molecular dynamics simulations, Markov state models (MSMs), and nonequilibrium statistical mechanical theory to probe dissipation in two key classes of signaling proteins: kinases and G-protein-coupled receptors (GPCRs). Applying machinery from large deviation theory, we use MSMs constructed from protein simulations to generate dynamics conforming to positive levels of entropy production. We note the emergence of an array of peaks in the dynamical response (transient analogs of phase transitions) that draw the proteins between distinct levels of dissipation, and we see that the binding of ATP and agonist molecules modifies the observed dissipative landscapes. Overall, we find that dissipation is tightly coupled to activation in these signaling systems: dominant entropy-producing trajectories become localized near important barriers along known biological activation pathways. We go on to classify an array of equilibrium and nonequilibrium molecular switches that harmonize to promote functional dynamics. PMID:26240354

  17. Rockets: An Educator's Guide with Activities in Science, Mathematics, and Technology.

    ERIC Educational Resources Information Center

    National Aeronautics and Space Administration, Washington, DC.

    This educational guide discusses rockets and includes activities in science, mathematics, and technology. It begins with background information on the history of rocketry, scientific principles, and practical rocketry. The sections on scientific principles and practical rocketry focus on Sir Isaac Newton's Three Laws of Motion. These laws explain…

  18. Living with a Star: An Educator Guide with Activities in Sun-Earth Sciences.

    ERIC Educational Resources Information Center

    National Aeronautics and Space Administration, Washington, DC.

    This educator guide is designed to provide references and resource materials to K-12 educators about the connection between the sun and the earth. Chapters include: (1) "Common Questions and Answers"; (2) "Sun-Earth Connection Missions"; (3) "Website Resources"; (4) "NASA CORE Materials"; (5) "Activities"; (6) "NASA Educator Workshop Resources";…

  19. Rare & Endangered Species: Understanding Our Disappearing Plants and Animals. Activities Guide.

    ERIC Educational Resources Information Center

    American Gas Association, Arlington, VA. Educational Services.

    About 464 plants and animals found in the United States and its territories are listed by the U.S. Fish and Wildlife Service as threatened or endangered. Another 3900 are candidates for protection. The activities in this guide are designed to help teachers and students understand the issue of endangered species. It includes ideas for several…

  20. Acid Rain. Activities for Grades 4 to 12. A Teacher's Guide.

    ERIC Educational Resources Information Center

    Wood, David; Bryant, Jeannette

    This teacher's guide on acid rain is divided into three study areas to explain: (1) what causes acid rain; (2) what problems acid rain has created; and (3) what teachers and students can do to help combat acid rain. Instructions for activities within the study areas include suggested grade levels, objectives, materials needed, and directions for…

  1. Activities for Learning about Conservation of Forest Resources: A Guide for Leaders of Youth Groups.

    ERIC Educational Resources Information Center

    Forest Service (USDA), Washington, DC.

    This guide is intended to support the leader of a youth group in increasing the awareness of members of the need for good forest conservation practices. Sections include: (1) science fundamentals; (2) making informative exhibits; (3) gaining community involvement; (4) Christmas activities; (5) games and crafts; and (6) a list of resources and…

  2. Optics: Light, Color, and Their Uses. An Educator's Guide with Activities in Science and Mathematics.

    ERIC Educational Resources Information Center

    National Aeronautics and Space Administration, Huntsville, AL. George C. Marshall Space Flight Center.

    This educator's guide from discusses optics, light, color and their uses. Activities include: (1) "Reflection of Light with a Plane (Flat) Mirror--Trace a Star"; (2) "Reflection of Light with Two Plane Mirrors--Double Mirrors Placed at a 90-Degree Angle"; (3) "Reflection of Light with Two Plane Mirrors--Double Mirrors Placed at a Number of…

  3. Bubble Festival: Presenting Bubble Activities in a Learning Station Format. Teacher's Guide.

    ERIC Educational Resources Information Center

    Barber, Jacqueline; Willard, Carolyn

    This learning station guide adapts the Bubble Festival, an all-school event, for individual classrooms. It presents students with a variety of different challenges at learning stations set up around the classroom. The activities are student-centered and involve open-ended investigations. Also included are ways to extend students' experiences at…

  4. For Spacious Skies Activity Guide. An Interdisciplinary Approach to the Sky.

    ERIC Educational Resources Information Center

    Ward, C. Whitney; Borden, Jack

    Despite the fact that the sky is the most dominant feature of our surroundings, it plays the role of an unseen background for may objects. It is the intent of this guide to bring about an awareness of the sky to young people. Topics for activities include: (1) "Sky Awareness"; (2) "Compass"; (3) "Hand Lens"; (4) "Prism"; (5) "Binoculars"; (6)…

  5. An active lighting module with natural light guiding system and solid state source for indoor illumination

    NASA Astrophysics Data System (ADS)

    Chen, Chi-An; Chen, Yi-Yung; Whang, Allen Jong-Woei

    2009-08-01

    Recently, many researches focus on healthy lighting with sunlight. A Natural Light Guiding System includes collecting, transmitting, and lighting parts. In general, the lighting module of the Natural Light Guiding System only uses scattering element, such as diffuser, to achieve uniform illumination. With the passive lighting module, the application of the Natural Light Guiding System is limited because sunlight is dynamic source. When the sunlight is weak at morning, at evening, or on cloudy day, the illumination system is fail. In this paper, we provide an active lighting module that includes the lighting part of Natural Light Guiding System, LED auxiliary sources, optical elements, and optical detector. We use optical simulation tool to design and simulate the efficiency of the active module. The optical element can redistribute the sunlight only, LED light only, or sunlight with LED light to achieve uniform illumination. With the feedback of the detector, the active lighting module will adjust the intensity of LED to provide a steady illumination. Moreover, the module could replace the backlight module of LCD TV when the house has Natural Light Guiding System for saving energy and higher performance of image.

  6. A hitchhiker's guide to assessing young people's physical activity: Deciding what method to use.

    PubMed

    Dollman, James; Okely, Anthony D; Hardy, Louise; Timperio, Anna; Salmon, Jo; Hills, Andrew P

    2009-09-01

    Researchers and practitioners interested in assessing physical activity in children are often faced with the dilemma of what instrument to use. While there is a plethora of physical activity instruments to choose from, there is currently no guide regarding the suitability of common assessment instruments. The purpose of this paper is to provide a user's guide for selecting physical activity assessment instruments appropriate for use with children and adolescents. While recommendations regarding specific instruments are not provided, the guide offers information about key attributes and considerations for the use of eight physical activity assessment approaches: heart rate monitoring; accelerometry; pedometry; direct observation; self-report; parent report; teacher report; and diaries/logs. Attributes of instruments and other factors to be considered in the selection of assessment instruments include: population (age); sample size; respondent burden; method/delivery mode; assessment time frame; physical activity information required (data output); data management; measurement error; cost (instrument and administration) and other limitations. A decision flow chart has been developed to assist researchers and practitioners to select an appropriate method of assessing physical activity. Five real-life scenarios are presented to illustrate this process in light of key instrument attributes. It is important that researchers, practitioners and policy makers understand the strengths and limitations of different methods of assessing physical activity, and are guided on selection of the most appropriate instrument/s to suit their needs. PMID:19038579

  7. Driver Performance Measurement Research. Volume 2: Guide for Training Observer/Raters in the Driver Performance Measurements Procedure. (Including Course and Content).

    ERIC Educational Resources Information Center

    Nolan, R. O.; And Others

    The Final Report, Volume 1, covers research results of the Michigan State University Driver Performance Measurement Project. This volume (Volume 2) constitutes a guide for training observers/raters in the driver performance measurement procedures developed in this research by MSU. The guide includes a training course plan and content materials…

  8. Optimal design of active and semi-active suspensions including time delays and preview

    NASA Astrophysics Data System (ADS)

    Hac', A.; Youn, I.

    1993-10-01

    Several control laws for active and semi-active suspension based on a linear half car model are derived and investigated. The strategies proposed take full advantage of the fact that the road input to the rear wheels is a delayed version of that to the front wheels, which in turn can be obtained either from the measurements of the front wheels and body motions or by direct preview of road irregularities if preview sensors are available. The suspension systems are optimized with respect to ride comfort, road holding and suspension rattle space as expressed by the mean-square-values of body acceleration (including effects of heave and pitch), tire deflections and front and rear suspension travels. The optimal control laws that minimize the given performance index and include passivity constraints in the semi-active case are derived using calculus of variation. The optimal semi-active suspension becomes piecewise linear, varying between passive and fully active systems and combinations of them. The performances of active and semi-active systems with and without preview were evaluated by numerical simulation in the time and frequency domains. The results show that incorporation of time delay between the front and rear axles in controller design improves the dynamic behavior of the rear axle and control of body pitch motion, while additional preview improves front wheel dynamics and body heave.

  9. Backyards and Butterflies: Ways to Include Children with Disabilities in Outdoor Activities.

    ERIC Educational Resources Information Center

    Greenstein, Doreen; And Others

    This sourcebook is designed for children, parents, and families, detailing ideas for outdoor play and learning activities, with emphasis on involving children with disabilities in outdoor play. A rural perspective permeates the guide, although each chapter contains ideas for making outdoor environments more accessible and safer for all children,…

  10. Ute Unit: Study Guide and Follow Up Activities.

    ERIC Educational Resources Information Center

    North Conejos School District, Capulin, CO.

    The study guide and follow-up activities were designed primarily to give students a feeling of Ute life in the San Luis Valley in Colorado. The unit begins with six Southern Ute stories about the wolf and coyote, the race between the skunk and the coyote, the frog and the eagle, why the frog croaks, the bear (Que Ye Qat), and the two Indian…

  11. Be Active Your Way: A Guide for Adults

    MedlinePlus

    ... aerobic activities include things like brisk walking, running, dancing, swimming, and playing basketball. Also include strengthening activities ... the ones you will try): ❑ Biking slowly ❑ Canoeing ❑ Dancing ❑ General gardening (raking, trimming shrubs) ❑ Tennis (doubles) ❑ Using ...

  12. A Study of Image-Guided Intensity-Modulated Radiotherapy With Fiducials for Localized Prostate Cancer Including Pelvic Lymph Nodes

    SciTech Connect

    Hsu, Annie; Pawlicki, Todd; Luxton, Gary; Hara, Wendy; King, Christopher R. . E-mail: crking@stanford.edu

    2007-07-01

    Purpose: To study the impact on nodal coverage and dose to fixed organs at risk when using daily fiducial localization of the prostate to deliver intensity-modulated radiotherapy (IMRT). Methods and Materials: Five patients with prostate cancer in whom prostate and pelvic nodes were irradiated with IMRT were studied. Dose was prescribed such that 95% of the prostate planning target volume (PTV) and 90% of the nodal PTV were covered. Random and systematic prostate displacements in the anterior-posterior, superior-inferior, and left-right directions were simulated to shift the original isocenter of the IMRT plan. The composite dose during the course of treatment was calculated. Results: Compared with a static setup, simulating random shifts reduced dose by less than 1.5% for nodal hotspot (i.e., dose to 1 cm{sup 3}), by less than 1% for the 90% nodal PTV coverage, and by less than 0.5% for the nodal mean dose. Bowel and femoral head hotspots were reduced by less than 1.5% and 2%, respectively. A 10-mm systematic offset reduced nodal coverage by up to 10%. Conclusion: The use of prostate fiducials for daily localization during IMRT treatment results in negligible changes in dose coverage of pelvic nodes or normal tissue sparing in the absence of a significant systematic offset. This offers a simple and practical solution to the problem of image-guided radiotherapy for prostate cancer when including pelvic nodes.

  13. A novel, variable angle guide grid for neuronal activity studies

    PubMed Central

    Talbot, Thomas; Ide, David; Liu, Ning; Turchi, Janita

    2011-01-01

    Introduction: Surgically implanted chambers with removable grids are routinely used for studying patterns of neuronal activity in primate brains; however, accessing target tissues is significantly constrained by standard grid designs. Typically, grids are configured with a series of guide holes drilled vertically, parallel to the walls of the chamber, thus targeted sites are limited to those in line vertically with one of the guide holes. Methods: By using the three-dimensional modeling software, a novel grid was designed to reach the targeted sites far beyond the standard reach of the chamber. The grid was fabricated using conventional machining techniques and three-dimensional printing. Results: A pilot study involving microinjection of the magnetic resonance (MR) contrast agent gadolinium into the discrete regions of interest (ROIs) in the temporal cortex of an awake, behaving monkey demonstrated the effectiveness of this new design of the guide grid. Using multiple different angles of approach, we were readily able to access 10 injection sites, which were up to 5 mm outside the traditional, orthogonal reach of the chamber. PMID:22319479

  14. Structure Guided Optimization, in Vitro Activity, and in Vivo Activity of Pan-PIM Kinase Inhibitors.

    PubMed

    Burger, Matthew T; Han, Wooseok; Lan, Jiong; Nishiguchi, Gisele; Bellamacina, Cornelia; Lindval, Mika; Atallah, Gordana; Ding, Yu; Mathur, Michelle; McBride, Chris; Beans, Elizabeth L; Muller, Kristine; Tamez, Victoriano; Zhang, Yanchen; Huh, Kay; Feucht, Paul; Zavorotinskaya, Tatiana; Dai, Yumin; Holash, Jocelyn; Castillo, Joseph; Langowski, John; Wang, Yingyun; Chen, Min Y; Garcia, Pablo D

    2013-12-12

    Proviral insertion of Moloney virus (PIM) 1, 2, and 3 kinases are serine/threonine kinases that normally function in survival and proliferation of hematopoietic cells. As high expression of PIM1, 2, and 3 is frequently observed in many human malignancies, including multiple myeloma, non-Hodgkins lymphoma, and myeloid leukemias, there is interest in determining whether selective PIM inhibition can improve outcomes of these human cancers. Herein, we describe our efforts toward this goal. The structure guided optimization of a singleton high throughput screening hit in which the potency against all three PIM isoforms was increased >10,000-fold to yield compounds with pan PIM K is < 10 pM, nanomolar cellular potency, and in vivo activity in an acute myeloid leukemia Pim-dependent tumor model is described. PMID:24900629

  15. Space-Based Astronomy: An Educator Guide with Activities for Science, Mathematics, and Technology Education.

    ERIC Educational Resources Information Center

    Vogt, Gregory L.

    This educator's guide features activities for science, mathematics, and technology education. The activities in this curriculum guide were developed based on the hands-on approach. The guide starts with introductory information and is followed by five units: (1) "The Atmospheric Filter"; (2) "The Electromagnetic Spectrum"; (3) "Collecting…

  16. Energy Storage. Teachers Guide. Science Activities in Energy.

    ERIC Educational Resources Information Center

    Jacobs, Mary Lynn, Ed.

    Included in this science activities energy package for students in grades 4-10 are 12 activities related to energy storage. Each activity is outlined on the front and back of a single sheet and is introduced by a key question. Most of the activities can be completed in the classroom with materials readily available in any community. Among the…

  17. Development of Active Catheter,Active Guide Wire and Micro Sensor Systems

    PubMed Central

    Haga, Y.; Mineta, T.; Totsu, K.; Makishi, W.; Esashi, M.

    2001-01-01

    Summary Active catheters and active guide wires which move like a snake have been developed for catheter-based minimally invasive diagnosis and therapy. Communication and control IC chips in the active catheter reduce the number of lead wires for control. The active catheter can be not only bent but also torsioned and extended. An ultra minature fiber-optic pressure sensor; a forward-looking ultrasonic probe and a magnetic position and orientation sensor have been developed for catheters and guide wires. These moving mechanisms and several sensors which are fitted near the tip of the catheter and the guide wire will provide detailed information near the tip and enable delicate and effective catheter intervention. PMID:20663389

  18. Assessment of visiting activities for young children using the UNAWE Evaluation Guide

    NASA Astrophysics Data System (ADS)

    Tomita, Akihiko

    2015-08-01

    When the target is young children and the activity type is play, the assessment of the activity is not easy. The table of domains of active learning shown in the EU Universe Awareness Programme Evaluation Guide is useful for the assessment; the Guide shows the four domains; motivation, scientific skills, universe knowledge, and intercultural attitudes, and many items of objectives in each domains. The Guide can be a basic format and the items can be modified so as to fit each activity. Taking my activity as an example, I will present an assessment using the Guide. The activity I will present is "Uchu no O-hanashi," a visiting activity which includeds slide show, story telling, and enjoying pictures on large sheets for children at nursery, kindergarten, preschool and other sites. In order to obtain the data, I have recorded the voice of children. The analysis method is a kind of qualitative one. I picked up "motivation" and "scientific skills" words from the record when they muttered about and asked each other what they felt, what they found, and what they got excited about. Among the items in the "scientific skills domain," looking at carefully, asking, exchanging opinions, interpreting or trying to interpret, and trying were frequently appeared. Other skills such as devising and confirming were not frequently appeared but they would sometimes appear later at home or at school after the activity. I also picked up the words of children obtaining scientific way of view and attitude through the activity. One example is "It seems that stars float in the sky and do not move. Do they really set like the Sun, our nearest star? I never saw stars set!" A boy was trying to make a new framework for his understanding. This kind of thinking will enrich his or her future "universe knowledge" and "intercultural attitudes."

  19. Closed-loop and activity-guided optogenetic control.

    PubMed

    Grosenick, Logan; Marshel, James H; Deisseroth, Karl

    2015-04-01

    Advances in optical manipulation and observation of neural activity have set the stage for widespread implementation of closed-loop and activity-guided optical control of neural circuit dynamics. Closing the loop optogenetically (i.e., basing optogenetic stimulation on simultaneously observed dynamics in a principled way) is a powerful strategy for causal investigation of neural circuitry. In particular, observing and feeding back the effects of circuit interventions on physiologically relevant timescales is valuable for directly testing whether inferred models of dynamics, connectivity, and causation are accurate in vivo. Here we highlight technical and theoretical foundations as well as recent advances and opportunities in this area, and we review in detail the known caveats and limitations of optogenetic experimentation in the context of addressing these challenges with closed-loop optogenetic control in behaving animals. PMID:25856490

  20. Active constraint control for image-guided robotic surgery.

    PubMed

    Yen, P-L; Davies, B L

    2010-01-01

    The concept of active constraint control for image-guided robotic surgery is introduced, together with its benefits and a short outline of its history. The clinical use of active constraint control in orthopaedic surgery is discussed, together with the outcomes of a clinical trial for unicondylar knee replacement surgery. The evolution of the robotic design from large costly structures towards simpler, more cost-effective systems is also presented, leading to the design of the Acrobot 'Sculptor' system. A new approach to the achievement of robotic total knee replacement is also presented, in which a high-speed rotary cutter is used to slice through the bone to achieve a speedy resection. The control concept is presented, together with the results of trials on animal bones and a cadaver, showing that it is possible to remove large quantities of bone both quickly and accurately. PMID:20718267

  1. Closed-Loop and Activity-Guided Optogenetic Control

    PubMed Central

    Grosenick, Logan; Marshel, James H.; Deisseroth, Karl

    2016-01-01

    Advances in optical manipulation and observation of neural activity have set the stage for widespread implementation of closed-loop and activity-guided optical control of neural circuit dynamics. Closing the loop optogenetically (i.e., basing optogenetic stimulation on simultaneously observed dynamics in a principled way) is a powerful strategy for causal investigation of neural circuitry. In particular, observing and feeding back the effects of circuit interventions on physiologically relevant timescales is valuable for directly testing whether inferred models of dynamics, connectivity, and causation are accurate in vivo. Here we highlight technical and theoretical foundations as well as recent advances and opportunities in this area, and we review in detail the known caveats and limitations of optogenetic experimentation in the context of addressing these challenges with closed-loop optogenetic control in behaving animals. PMID:25856490

  2. Guided cobalamin biosynthesis supports Dehalococcoides mccartyi reductive dechlorination activity

    PubMed Central

    Yan, Jun; Im, Jeongdae; Yang, Yi; Löffler, Frank E.

    2013-01-01

    Dehalococcoides mccartyi strains are corrinoid-auxotrophic Bacteria and axenic cultures that require vitamin B12 (CN-Cbl) to conserve energy via organohalide respiration. Cultures of D. mccartyi strains BAV1, GT and FL2 grown with limiting amounts of 1 µg l−1 CN-Cbl quickly depleted CN-Cbl, and reductive dechlorination of polychlorinated ethenes was incomplete leading to vinyl chloride (VC) accumulation. In contrast, the same cultures amended with 25 µg l−1 CN-Cbl exhibited up to 2.3-fold higher dechlorination rates, 2.8–9.1-fold increased growth yields, and completely consumed growth-supporting chlorinated ethenes. To explore whether known cobamide-producing microbes supply Dehalococcoides with the required corrinoid cofactor, co-culture experiments were performed with the methanogen Methanosarcina barkeri strain Fusaro and two acetogens, Sporomusa ovata and Sporomusa sp. strain KB-1, as Dehalococcoides partner populations. During growth with H2/CO2, M. barkeri axenic cultures produced 4.2 ± 0.1 µg l−1 extracellular cobamide (factor III), whereas the Sporomusa cultures produced phenolyl- and p-cresolyl-cobamides. Neither factor III nor the phenolic cobamides supported Dehalococcoides reductive dechlorination activity suggesting that M. barkeri and the Sporomusa sp. cannot fulfil Dehalococcoides' nutritional requirements. Dehalococcoides dechlorination activity and growth occurred in M. barkeri and Sporomusa sp. co-cultures amended with 10 µM 5′,6′-dimethylbenzimidazole (DMB), indicating that a cobalamin is a preferred corrinoid cofactor of strains BAV1, GT and FL2 when grown with chlorinated ethenes as electron acceptors. Even though the methanogen and acetogen populations tested did not produce cobalamin, the addition of DMB enabled guided biosynthesis and generated a cobalamin that supported Dehalococcoides' activity and growth. Guided cobalamin biosynthesis may offer opportunities to sustain and enhance Dehalococcoides activity in contaminated

  3. Quick Reference Guide: Working with Stakeholders to Identify Potential Improvement Strategies for Program Improvement (Including the SSIP)

    ERIC Educational Resources Information Center

    Center for IDEA Early Childhood Data Systems (DaSy), 2015

    2015-01-01

    This 2015 quick reference guide is designed to assist states in understanding what information needs to be available in order for stakeholders to assist in selecting potential improvement strategies that will increase capacity of Local Education Agencies (LEAs), Early Intervention Services (EIS) programs, and practitioners to improve results for…

  4. Practical Nursing Curriculum Guide. Including the Expanded Functions of I.V. Therapy and LPN Management. Invest in Success.

    ERIC Educational Resources Information Center

    Idaho State Dept. of Education, Boise. Div. of Vocational Education.

    Under the Idaho state system for curriculum development in vocational education, Technical Committees made up solely of industry personnel are responsible for drawing up task lists for each program. The first part of this guide contains a curriculum for instruction of practical nurses who are eligible to sit for the license examination upon…

  5. EULAR Sjögren's syndrome disease activity index (ESSDAI): a user guide

    PubMed Central

    Seror, Raphaèle; Bowman, Simon J; Brito-Zeron, Pilar; Theander, Elke; Bootsma, Hendrika; Tzioufas, Athanasios; Gottenberg, Jacques-Eric; Ramos-Casals, Manel; Dörner, Thomas; Ravaud, Philippe; Vitali, Claudio; Mariette, Xavier

    2015-01-01

    The EULAR Sjögren's syndrome (SS) disease activity index (ESSDAI) is a systemic disease activity index that was designed to measure disease activity in patients with primary SS. With the growing use of the ESSDAI, some domains appear to be more challenging to rate than others. The ESSDAI is now in use as a gold standard to measure disease activity in clinical studies, and as an outcome measure, even a primary outcome measure, in current randomised clinical trials. Therefore, ensuring an accurate and reproducible rating of each domain, by providing a more detailed definition of each domain, has emerged as an urgent need. The purpose of the present article is to provide a user guide for the ESSDAI. This guide provides definitions and precisions on the rating of each domain. It also includes some minor improvement of the score to integrate advance in knowledge of disease manifestations. This user guide may help clinicians to use the ESSDAI, and increase the reliability of rating and consequently of the ability to detect true changes over time. This better appraisal of ESSDAI items, along with the recent definition of disease activity levels and minimal clinically important change, will improve the assessment of patients with primary SS and facilitate the demonstration of effectiveness of treatment for patients with primary SS. PMID:26509054

  6. Creative Environmental Education Activities for Children. Environmental Education Curriculum Guide.

    ERIC Educational Resources Information Center

    Tennessee Valley Authority (Land Between the Lakes), Golden Pond, KY.

    Twenty-seven activities have been compiled to assist teachers in incorporating environmental methods and techniques into their preschool curricula. These activities are designed to complement the classroom curriculum and heighten participant awareness and appreciation of environmental resources and relationships. Each activity includes: (1)…

  7. Learning to Fly: The Wright Brothers' Adventure. A Guide for Educators and Students with Activities in Aeronautics

    ERIC Educational Resources Information Center

    Storm, Roger; Benson, Thomas; Galica, Carol; McCredie, Patty

    2003-01-01

    This educator guide provides background information on Wilbur and Orville Wright. It also presents activities on aeronautics that provide templates for building the 1900, 1901, and 1902 Gliders and the 1903 Flyer. Activities include: (1) Early Aviation; (2) Your First Interview; (3) Your First Report; (4) Build a Model of the 1900 Glider; (5)…

  8. A Curriculum Activities Guide to Selected Environmental Topics for Use With Elementary and Junior High School Students.

    ERIC Educational Resources Information Center

    Sexton, Alan D., Ed.

    This guide contains learning activities in environmental education developed by teachers and intended for use at the elementary or junior high school levels. Topics covered include: water, esthetics, air, soil and sediment, solid waste, energy, noise, population, and transportation. Generally, each activity contains an introduction, a listing of…

  9. A novel self-guided approach to alpha activity training.

    PubMed

    van Boxtel, Geert J M; Denissen, Ad J M; Jäger, Mark; Vernon, David; Dekker, Marian K J; Mihajlović, Vojkan; Sitskoorn, Margriet M

    2012-03-01

    Fifty healthy participants took part in a double-blind placebo-controlled study in which they were either given auditory alpha activity (8-12Hz) training (N=18), random beta training (N=12), or no training at all (N=20). A novel wireless electrode system was used for training without instructions, involving water-based electrodes mounted in an audio headset. Training was applied approximately at central electrodes. Post-training measurement using a conventional full-cap EEG system revealed a 10% increase in alpha activity at posterior sites compared to pre-training levels, when using the conventional index of alpha activity and a non-linear regression fit intended to model individual alpha frequency. This statistically significant increase was present only in the group that received the alpha training, and remained evident at a 3 month follow-up session, especially under eyes open conditions where an additional 10% increase was found. In an exit interview, approximately twice as many participants in the alpha training group (53%) mentioned that the training was relaxing, compared to those in either the beta (20%) or no training (21%) control groups. Behavioural measures of stress and relaxation were indicative of effects of alpha activity training but failed to reach statistical significance. These results are discussed in terms of a lack of statistical power. Overall, results suggest that self-guided alpha activity training using this novel system is feasible and represents a step forward in the ease of instrumental conditioning of brain rhythms. PMID:22119661

  10. Task Rotation: Strategies for Differentiating Activities and Assessments by Learning Style. A Strategic Teacher PLC Guide

    ERIC Educational Resources Information Center

    Silver, Harvey; Moirao, Daniel; Jackson, Joyce

    2011-01-01

    One of the hardest jobs in teaching is to differentiate learning activities and assessments to your students' learning styles. But you and your colleagues can learn how to do this together when each of you has this guide to the Task Rotation strategy from our ultimate guide to teaching strategies, "The Strategic Teacher". Use the guide in your…

  11. Learning to Fly: The Wright Brothers' Adventure. A Guide for Educators and Students with Activities in Aeronautics

    NASA Technical Reports Server (NTRS)

    Storm, R.; Benson, T.; Galica, C.; McCredie, P.

    2003-01-01

    This guide was produced by the NASA Glenn Research Center Office of Educational Programs in Cleveland, OH, and the NASA Aerospace Educational Coordinating Committee. It includes activity modules for students, including the history of the Wright Brothers and their family in Dayton, Ohio and flight experimentation in Kitty Hawk, North Carolina. Student activities such as building models of the Wright Brothers glider and writing press releases of the initial flight are included.

  12. Popullution or Conservival: A Guide to Activities and Strategies in Environmental Education, Grades 6-8.

    ERIC Educational Resources Information Center

    Graham, Phyllis; And Others

    This teaching guide contains a variety of environmental education activities divided by grade level. A general objective is stated, followed by as many as 25 related activities. Each activity is short, and many are followed by discussion questions. This guide should prepare students for critical appraisal and responsible decision-making in…

  13. Anticipation Guides: Ready-to-Use Guides & Fun Activities to Boost Reading Comprehension

    ERIC Educational Resources Information Center

    Hines, Joanne I; Vincent, Pamela J.

    2004-01-01

    Anticipation guides--work sheets that students complete before reading a book--can be invaluable tools for building prediction skills and helping students learn where to focus their attention. In this book, veteran teachers Joanne I. Hines and Pamela J. Vincent offer classroom-tested anticipation guides for a variety of trade books sure to engage…

  14. Continuing German in Grade Five: MLA Teacher's Guide. A Course of Study Including Methods, Materials, and Aids for Teaching German to Fifth-Grade Pupils.

    ERIC Educational Resources Information Center

    Memming, Agnes K.; And Others

    This teacher's guide, for use in a fifth-grade German course, contains 12 units of instructional materials which concentrate on the development of basic audiolingual skills. Each of the units consists of conversational skits, dialogue adaptation, directed dialogue review, and classroom drills. Units include: (1) Das Aufstehen und das Fruhstuck,…

  15. Continuing French in Grade Four: MLA Teacher's Guide. A Course of Study Including Methods, Materials, and Aids for Teaching French to Fourth-Grade Children.

    ERIC Educational Resources Information Center

    Thompson, Mary P.; And Others

    This teacher's guide for use in a fourth-grade French course concentrates on the development of basic audiolingual skills. Twelve lessons, each containing an exposition, dialogue, teaching procedures, and dialogue adaptation, emphasize the use of French during classroom instruction. Lessons include: (1) a review unit, (2) "La chemise neuve," (3)…

  16. Active beam shaping in multiple laser guide stars

    NASA Astrophysics Data System (ADS)

    Jones, Katharine J.

    2012-10-01

    Adaptive beam shaping is a critical part of multiple Laser Guide Stars (LGS) for Multiple Conjugate Adaptive Optics (MCAO) for ground-based astronomical telescopes. There are two kinds of Laser Guide Stars: Na Laser Guide Stars (at 589 nm and 92 km altitude) and Rayleigh Laser Guide Stars (at 532 nm and 20 km altitude). Multiple Conjugate Adaptive Optics (MCAO) corrects for each "layer" of atmosphere independently. Multiple Laser Guide Stars are being developed to achieve a measure of tilt and increase the isoplanatic patch. Multiple Laser Guide Stars are being combined with Multiple Conjugate Optics in the Large Binocular Telescope (LBT): more than one Laser Guide Star (4-5) and two different wavelengths: 589 nm and 532 nm. Other observatories have multiple Laser Guide Stars but only one wavelength: 589 nm or 532 nm. Because Laser Guide Stars are launched into the atmosphere, adaptive beam shaping will be carried out before the laser is launched and will be different depending on which laser is being used, presumably to effect the tightest beam which can be achieved at the power level which is required to provide the requisite return to gound-based wavefront sensors. A complete range of devices are used. Beam attenuation and divergnece will take place. Multiple Laser Guide Stars of major observatories (SOR, LBT, MMT, ESO VLT and Gemini South) will be evaluated for effective adaptive beam shaping and impact on performance

  17. Looking at Earth from Space: Teacher's Guide with Activities for Earth and Space Science

    NASA Technical Reports Server (NTRS)

    Steele, Colleen (Editor); Steele, Colleen; Ryan, William F.

    1995-01-01

    The Maryland Pilot Earth Science and Technology Education Network (MAPS-NET) project was sponsored by the National Aeronautics and Space Administration (NASA) to enrich teacher preparation and classroom learning in the area of Earth system science. This publication includes a teacher's guide that replicates material taught during a graduate-level course of the project and activities developed by the teachers. The publication was developed to provide teachers with a comprehensive approach to using satellite imagery to enhance science education. The teacher's guide is divided into topical chapters and enables teachers to expand their knowledge of the atmosphere, common weather patterns, and remote sensing. Topics include: weather systems and satellite imagery including mid-latitude weather systems; wave motion and the general circulation; cyclonic disturbances and baroclinic instability; clouds; additional common weather patterns; satellite images and the internet; environmental satellites; orbits; and ground station set-up. Activities are listed by suggested grade level and include the following topics: using weather symbols; forecasting the weather; cloud families and identification; classification of cloud types through infrared Automatic Picture Transmission (APT) imagery; comparison of visible and infrared imagery; cold fronts; to ski or not to ski (imagery as a decision making tool), infrared and visible satellite images; thunderstorms; looping satellite images; hurricanes; intertropical convergence zone; and using weather satellite images to enhance a study of the Chesapeake Bay. A list of resources is also included.

  18. 7 CFR 981.441 - Credit for market promotion activities, including paid advertising.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... promotion activities, including paid advertising. (a) In order for a handler to receive credit for his/her own promotional activities from his/her pro rata portion of advertising assessment payments, pursuant... professional practices and rates for the type of activity conducted. In the case of claims for...

  19. 7 CFR 981.441 - Credit for market promotion activities, including paid advertising.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... promotion activities, including paid advertising. (a) In order for a handler to receive credit for his/her own promotional activities from his/her pro rata portion of advertising assessment payments, pursuant... professional practices and rates for the type of activity conducted. In the case of claims for...

  20. 7 CFR 981.441 - Credit for market promotion activities, including paid advertising.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... promotion activities, including paid advertising. (a) In order for a handler to receive credit for his/her own promotional activities from his/her pro rata portion of advertising assessment payments, pursuant... professional practices and rates for the type of activity conducted. In the case of claims for...

  1. 7 CFR 981.441 - Credit for market promotion activities, including paid advertising.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... promotion activities, including paid advertising. (a) In order for a handler to receive credit for his/her own promotional activities from his/her pro rata portion of advertising assessment payments, pursuant... professional practices and rates for the type of activity conducted. In the case of claims for...

  2. Internet Activities Using Scientific Data. A Self-Guided Exploration.

    ERIC Educational Resources Information Center

    Froseth, Stan; Poppe, Barbara

    This guide is intended for the secondary school teacher (especially math or science) or the student who wants to access and learn about scientific data on the Internet. It is organized as a self-guided exploration. Nine exercises enable the user to access and analyze on-line information from the National Oceanic and Atmospheric Administration…

  3. Homesteading: The Free Land Idea. An Activity Guide for Teachers Grades 4 through 6.

    ERIC Educational Resources Information Center

    Lamberson, Wesley; Lange, L. S.; Sutter, Jason; Sutter, Gail

    This curriculum/activity guide is designed for use by teachers and other educators who live within trip distance of Homestead National Monument of America in Nebraska. However, some activities in the guide are designed for the classroom, and some are more effective if they are conducted outdoors; but many can be completed at school. The activity…

  4. Printing & Publishing from the Classroom to Careers. An Activity Guide for Teachers.

    ERIC Educational Resources Information Center

    Bulen, Robert

    This activity guide was developed in Oregon using the theme of the 150th anniversary of the Oregon Trail to help teachers conduct classroom activities that make use of the skills involved in printing and publishing. It was written by a classroom teacher and designed and published by the printing industry. The guide has the following six purposes:…

  5. Guide to federal export assistance activities applicable to the US coal and coal technologies industry

    SciTech Connect

    Not Available

    1989-09-01

    The federal government provides a complete range of programs and services that can assist United States (US) coal and coal-technology firms as they expand into the foreign marketplace. These programs cover the spectrum of business export needs, which include: providing assistance in identifying target markets, locating specific business opportunities and foreign joint-venture partners, arranging business appointments, organizing trade missions, sponsoring feasibility studies, conducting trade analyses, providing financing, insuring investments, and providing in-country training and assistance. Under the sponsorship of the Department of Energy's (DOE) Office of Fossil Energy (FE), this Guide has been developed to address this problem. It is intended to provide coal and coal technology firms with a single reference source for identifying US government agencies, programs, and contacts that might aid in exporting. The Guide contains an in-depth discussion of the eight major agencies offering export assistance: the Agency for International Development (AID), the Departments of Commerce (DOC) and State (DOS), the Export-Import Bank (Eximbank), the Overseas Private Investment Corporation (OPIC), the Small Business Administration (SBA), the Trade and Development Program (TDP), and the Office of the US Trade Representative (USTR). In addition, this guide identifies pertinent activities performed by other federal agencies that might assist coal and coal-technologies exporters, including the Departments of Defense (DOD), Education, Energy (DOE), and Labor (DOL).

  6. PARK-IT! Elementary School Land Laboratories in Toledo City Parks. Curriculum Activity Guide, Grades K-1.

    ERIC Educational Resources Information Center

    DuFour, Marilyn Berry; Courter, Linda Kothera; Garvin, Dennis M.

    The project PARK-IT! represents a unique partnership between a public elementary school and a city park in which students and teachers utilize a small naturalized area of the park as a Land Laboratory, and in return become its stewards. The project also includes this curriculum activity guide which can assist teachers in using the Land Lab with…

  7. PARK-IT! Elementary School Land Laboratories in Toledo City Parks. Curriculum Activity Guide, Grades 2-3.

    ERIC Educational Resources Information Center

    DuFour, Marilyn Berry; Courter, Linda Kothera; Garvin, Dennis M.

    The project PARK-IT! represents a unique partnership between a public elementary school and a city park in which students and teachers utilize a small naturalized area of the park as a Land Laboratory, and in return become its stewards. The project also includes this curriculum activity guide which can assist teachers in using the Land Lab with…

  8. Hoppergrass and Stickerbush: A Beginning. A Guide to Activities and Strategies in Environmental Education, Grades K-5.

    ERIC Educational Resources Information Center

    Abbott, Cleo; And Others

    This publication serves as a guide to activities and strategies in environmental education. Lesson plans include objectives and suggested procedures in dealing with the following environmental concepts: (1) The earth is a vast but limited natural system; (2) The total environment is in constant change; (3) A living thing is the product of its…

  9. PARK-IT! Elementary School Land Laboratories in Toledo City Parks. Curriculum Activity Guide, Grades 4-6.

    ERIC Educational Resources Information Center

    DuFour, Marilyn Berry; Courter, Linda Kothera; Garvin, Dennis M.

    The project PARK-IT! represents a unique partnership between a public elementary school and a city park in which students and teachers utilize a small naturalized area of the park as a Land Laboratory, and in return become its stewards. The project also includes this curriculum activity guide which can assist teachers in using the Land Lab with…

  10. Recycling Study Guide.

    ERIC Educational Resources Information Center

    Hallowell, Anne; And Others

    This study guide was designed to help teachers and students understand the problems surrounding solid wastes. It includes an overview of solid waste and recycling, a glossary, suggested activities and a list of resource publications, audiovisual materials and organizations. There are 19 activity suggestions included in this guide designed for use…

  11. Improvements to the FATOLA computer program including added actively controlled landing gear subroutines

    NASA Technical Reports Server (NTRS)

    Mall, G. H.

    1983-01-01

    Modifications to a multi-degree-of-freedom flexible aircraft take-off and landing analysis (FATOLA) computer program, including a provision for actively controlled landing gears to expand the programs simulation capabilities, are presented. Supplemental instructions for preparation of data and for use of the modified program are included.

  12. Let's Meet Famous Women Artists. A Creative Art Activity Book. A Teacher's Guide Featuring 19 Famous Women Artists' Biographies and Enrichment/Research Activities.

    ERIC Educational Resources Information Center

    Badman, Jacqueline; Lewis-Spicer, Lisa

    This activity guide showcases the work of 19 women artists who have made outstanding contributions to the world of art in spite of the incredible obstacles society placed upon them. Artists, alphabetically presented, include: Sofonisba Anguissola, Rosa Bonheur, Deborah Butterfield, Rosalba Carriera, Janet Fish, Helen Frankenthaler, Giovanna…

  13. A Curriculum Activities Guide to Environment Studies with Students with Special Education Needs.

    ERIC Educational Resources Information Center

    Tully, Randolph R., Jr., Ed.

    Developed by teachers, the curriculum guide provides information on environmental studies activities for use with handicapped students. Activities are divided into three areas: awareness level activities (aesthetics, cemeteries, water, soil, air, noise, and miscellaneous activities); transition level activities (playgrounds, cemeteries, wildlife,…

  14. A Guide to Films, Filmstrips, Maps and Globes, Records on Asia. [and] Supplement, Including a New Section on Slides.

    ERIC Educational Resources Information Center

    Bell, Violet M., Comp.; And Others

    This third edition bibliography identifies and annotates selected films, filmstrips, maps and globes, and records which will contribute to increased knowledge and understanding of Asian peoples and cultures. (Asia is defined as including all countries from Afghanistan to Japan). A separate supplement, designed to be used with the third edition,…

  15. NASTRAN thermal analyzer: Theory and application including a guide to modeling engineering problems, volume 1. [thermal analyzer manual

    NASA Technical Reports Server (NTRS)

    Lee, H. P.

    1977-01-01

    The NASTRAN Thermal Analyzer Manual describes the fundamental and theoretical treatment of the finite element method, with emphasis on the derivations of the constituent matrices of different elements and solution algorithms. Necessary information and data relating to the practical applications of engineering modeling are included.

  16. That's Not Fair! A Teacher's Guide to Activism with Young Children.

    ERIC Educational Resources Information Center

    Pelo, Ann; Davidson, Fran

    Noting that young children have a natural sense of what is and is not fair, this guide is intended to help teachers develop an anti-bias curriculum using children's sense of fairness to guide them toward social activism. The book provides stories of children's experiences as activists, coupled with first-person accounts of teachers' experiences…

  17. Readings and Activities for Character Education: A Resource Guide for Teachers and Students.

    ERIC Educational Resources Information Center

    Brooks, Diane L.

    This resource guide, for teachers and students in the upper elementary and middle school grades, has been developed in response to the nationwide interest in asking schools to play an active role in preparing students to become informed and responsible citizens. The guide is divided into seven sections, one for each character trait: Caring, Civic…

  18. The mysterious atmosphere of the Earth. ATLAS: Instruction guide with activities

    NASA Technical Reports Server (NTRS)

    1993-01-01

    This teacher's guide presents lesson plans addressing various aspects of atmospheric physics and chemistry; the interactions between land, air, and sea; air pollution; and the mechanisms of climate change. The science concepts in this guide have been designed to complement the middle school curriculum. However, many activities can be used with younger or older students.

  19. Only One Ocean: Marine Science Activities for Grades 5-8. Teacher's Guide.

    ERIC Educational Resources Information Center

    Halversen, Catherine; Strang, Craig

    This guide was designed by the Marine Activities, Resources & Education (MARE) Program through the Great Explorations in Math and Science (GEMS) ongoing curriculum development program for middle school students. This GEMS guide addresses the concepts of the interconnectedness of the ocean basins, respect for organisms, oceanography, physical…

  20. Animals Alive! An Ecological Guide to Animal Activities. Revised Edition.

    ERIC Educational Resources Information Center

    Holley, Dennis

    This guide is designed to help teachers develop an inquiry-oriented program for studying the animal kingdom in which live animals are collected locally, studied, observed, and then released completely unharmed back into their natural habitats. This book addresses such concerns of life science teachers as the environmental soundness of methods and…

  1. A Guide for Perceptual-Motor Training Activities.

    ERIC Educational Resources Information Center

    South Euclid - Lyndhurst City Schools, Lyndhurst, OH.

    This document has been prepared as part of a kindergarten perceptual-training program of the South Euclid-Lyndhurst City School District near Cleveland, Ohio. The guide contains information on training and procedures related to perceptual-motor learning. This information is structured primarily into 150 lesson plans, devised as 30-minute sessions…

  2. Earth's Mysterious Atmosphere: Atlas 1 Teacher's Guide with Activities.

    ERIC Educational Resources Information Center

    Essex Corp., Huntsville, AL.

    This atmospheric studies teacher's guide for use with middle school students blends lessons in chemistry, physics, and the life, earth, and space sciences in an attempt to accomplish the following: to nurture students' natural curiosity and excitement about science, mathematics, and technology; to encourage career exploration in science,…

  3. Microgravity: A Teacher's Guide with Activities. Secondary Level.

    ERIC Educational Resources Information Center

    Vogt, Gregory L., Ed.; Wargo, Michael J., Ed.

    A microgravity environment is one that will impart to an object a net acceleration that is small compared with that produced by Earth at its surface. In practice, such acceleration will range from about one percent of Earth's gravitational acceleration to better than one part in a million. this teacher's guide presents an introduction to…

  4. A Curriculum Activities Guide to Water Pollution and Environmental Studies: Activities. Appendices, Volume 1 and Volume 2.

    ERIC Educational Resources Information Center

    Hershey, John T.; And Others

    This activity oriented guide is divided into four sections dealing with the Hydrologic Cycle; Human Activities; Ecological Perspectives; and Social and Political Factors. Each activity contains seven parts: (1) an introduction; (2) questions about the activity; (3) necessary equipment; (4) procedures; (5) results obtained by using the study; (6)…

  5. Solar sail attitude control including active nutation damping in a fixed-momentum wheel satellite

    NASA Technical Reports Server (NTRS)

    Azor, Ruth

    1992-01-01

    In geostationary cruise of a momentum biased satellite, it is necessary to stabilize the roll/yaw attitude due to disturbances, caused mainly by solar radiation pressure. This work presents a roll/yaw control which is obtained by the use of solar arrays and fixed flaps as actuators, with a horizon sensor for roll measurement. The design also includes an active nutation damping.

  6. Population and Human Development: A Course Curriculum Including Lesson Plans, Activities, and Bibliography. Revised.

    ERIC Educational Resources Information Center

    Murphy, Elaine M.; Long, Alison T.

    This course outline suggests materials and learning activities on the interrelated causes and consequences of population growth and other population matters. The document describes 15 class sessions which integrate information for sociology, anthropology, psychology, biology, animal behavior, and education. Topics include the history of human…

  7. A guide to modelling cardiac electrical activity in anatomically detailed ventricles.

    PubMed

    Clayton, R H; Panfilov, A V

    2008-01-01

    One of the most recent trends in cardiac electrophysiology is the development of integrative anatomically accurate models of the heart, which include description of cardiac activity from sub-cellular and cellular level to the level of the whole organ. In order to construct this type of model, a researcher needs to collect a wide range of information from books and journal articles on various aspects of biology, physiology, electrophysiology, numerical mathematics and computer programming. The aim of this methodological article is to survey recent developments in integrative modelling of electrical activity in the ventricles of the heart, and to provide a practical guide to the resources and tools that are available for work in this exciting and challenging area. PMID:17825362

  8. Design of Protease Activated Optical Contrast Agents That Exploit a Latent Lysosomotropic Effect for Use in Fluorescence-Guided Surgery

    PubMed Central

    2015-01-01

    There is a need for new molecular-guided contrast agents to enhance surgical procedures such as tumor resection that require a high degree of precision. Cysteine cathepsins are highly up-regulated in a wide variety of cancers, both in tumor cells and in the tumor-supporting cells of the surrounding stroma. Therefore, tools that can be used to dynamically monitor their activity in vivo could be used as imaging contrast agents for intraoperative fluorescence image guided surgery (FGS). Although multiple classes of cathepsin-targeted substrate probes have been reported, most suffer from overall fast clearance from sites of protease activation, leading to reduced signal intensity and duration in vivo. Here we describe the design and synthesis of a series of near-infrared fluorogenic probes that exploit a latent cationic lysosomotropic effect (LLE) to promote cellular retention upon protease activation. These probes show tumor-specific retention, fast activation kinetics, and rapid systemic distribution. We demonstrate that they are suitable for detection of diverse cancer types including breast, colon and lung tumors. Most importantly, the agents are compatible with the existing, FDA approved, da Vinci surgical system for fluorescence guided tumor resection. Therefore, our data suggest that the probes reported here can be used with existing clinical instrumentation to detect tumors and potentially other types of inflammatory lesions to guide surgical decision making in real time. PMID:26039341

  9. Disparity in Physical Activity among Urban Youth: An Ecologically Guided Assessment

    ERIC Educational Resources Information Center

    Lenhart, Clare M.; Patterson, Freda; Brown, Michael D.; O'Brien, Matthew J.; Nelson, Deborah B.

    2014-01-01

    Background: Insufficient physical activity among urban youth increases risk of chronic disease.Purpose:This study assessed reported physical activity to determine when disparities in participation emerge and what ecologically guided factors are linked with high activity. Methods:We administered a cross-sectional survey to a diverse sample of 321…

  10. Agriculture--Floriculture. Kit No. 104. Instructor's Manual and Student Learning Activity Guide.

    ERIC Educational Resources Information Center

    Huffman, Tommy

    Designed for use in a secondary agricultural education class, this activity kit on floriculture consists of an instructor's manual and a student learning guide. The instructor's manual contains this information: duration, goals, a list of instructional objectives, the vocational clusters to which this activity is related, activity implementation…

  11. ΔPK oncolytic activity includes modulation of the tumour cell milieu.

    PubMed

    Bollino, Dominique; Colunga, Aric; Li, Baiquan; Aurelian, Laure

    2016-02-01

    Oncolytic virotherapy is a unique cancer therapeutic that encompasses tumour cell lysis through both virus replication and programmed cell death (PCD) pathways. Nonetheless, clinical efficacy is relatively modest, likely related to the immunosuppressive tumour milieu. Our studies use the herpes simplex virus type 2 (HSV-2)-based oncolytic virus ΔPK that has documented anti-tumour activity associated with virus replication, PCD and cancer stem cell lysis. They are designed to examine whether ΔPK-mediated oncolysis includes the ability to reverse the immunosuppressive tumour microenvironment by altering the balance of cytokines directly secreted by the melanoma cells and to define its mechanism. Here, we show that melanoma cells secreted the immunosuppressive cytokine IL-10, and that secretion was inhibited by ΔPK through virus replication and c-Jun N-terminal kinase/c-Jun activation. ΔPK-induced IL-10 inhibition upregulated surface expression of MHC class I chain-related protein A, the ligand for the activating NKG2D receptor expressed on NK- and cytotoxic T-cells. Concomitantly, ΔPK also upregulated the secretion of inflammatory cytokines TNF-α, granulocyte macrophage colony-stimulating factor and IL-1β through autophagy-mediated activation of Toll-like receptor 2 pathways and pyroptosis, and it inhibited the expression of the negative immune checkpoint regulator cytotoxic T-lymphocyte antigen 4. Pharmacologic inhibition of these processes significantly reduces the oncolytic activity of ΔPK. PMID:26602205

  12. Active optics: variable curvature mirrors for ELT laser guide star refocusing systems

    NASA Astrophysics Data System (ADS)

    Challita, Zalpha; Hugot, Emmanuel; Madec, Fabrice; Ferrari, Marc; Le Mignant, David; Vivès, Sébastien; Cuby, Jean-Gabriel

    2011-10-01

    The future generation of Extremely Large Telescopes will require a complex combination of technologies for adaptive optics (AO) systems assisted by laser guide stars (LGS). In this context, the distance from the LGS spot to the telescope pupil ranges from about 80 to 200 km, depending on the Sodium layer altitude and the elevation of the telescope. This variation leads to a defocusing effect on the LGS wave-front sensor which needs to be compensated. We propose an active mirror able to compensate for this variation, based on an original optical design including this active optics component. This LGS Variable Curvature Mirror (LGS-VCM) is a 120 mm spherical active mirror able to achieve 820 μm deflection sag with an optical quality better than 150 nm RMS, allowing the radius of curvature variation from F/12 to F/2. Based on elasticity theory, the deformation of the metallic mirror is provided by an air pressure applied on a thin meniscus with a variable thickness distribution. In this article, we detail the analytical development leading to the specific geometry of the active component, the results of finite element analysis and the expected performances in terms of surface error versus the range of refocalisation. Three prototypes have been manufactured to compare the real behavior of the mirror and the simulations data. Results obtained on the prototypes are detailed, showing that the deformation of the VCM is very close to the simulation, and leads to a realistic active concept.

  13. Simple ray-tracing model for a rough surface of an ink layer including internal scattering particles printed on a light guide plate.

    PubMed

    Sekiguchi, Yoshifumi; Kaneko, Hiroki

    2016-02-01

    For simulating light guide lighting systems, we have developed a ray-tracing model for an ink layer extracting light from a light guide. The model consists of the volume and the rough surface scattering calculated on the basis of Mie theory and the facet model, respectively. The model of an ink layer was required to conserve energy for analyzing how much light loss occurs in each component in the lighting system. Though a single-scattering rough surface model with a shadowing/masking function successfully describes the scattering distribution, shadowing light violates the energy conservation law because of a lack of multiple scattering. We developed the rough surface ray-tracing model (RSRT model), which includes the multiple scattering instead of the shadowing/masking effect. We investigated the applicability of the RSRT model for an ink layer by comparing the RSRT model with recent physical and facet models. Finally, we compared the calculated and measured scattering distributions of an ink layer, applied the developed ink layer model to the lighting system, and confirmed the developed model to be valid. PMID:26836100

  14. Active seat suspension for a small vehicle: considerations for control system including observer

    NASA Astrophysics Data System (ADS)

    Katsumata, Hiroyuki; Shiino, Hiroshi; Oshinoya, Yasuo; Ishibashi, Kazuhisa; Ozaki, Koichi; Ogino, Hirohiko

    2007-12-01

    We have examined the improvement of ride quality and the reduction of riding fatigue brought about by the active control of the seat suspension of small vehicles such as one-seater electric automobiles. A small active seat suspension, which is easy to install, was designed and manufactured for one-seater electric automobiles. For the actuator, a maintenance-free voice coil motor used as a direct drive was adopted. For fundamental considerations, we designed a one-degree-of-freedom model for the active seat suspension system. Then, we designed a disturbance cancellation control system that includes the observer for a two-degree-of-freedom model. In an actual driving test, a test road, in which the concavity and convexity of an actual road surface were simulated using hard rubber, was prepared and the control performance of vertical vibrations of the seat surface during driving was examined. As a result, in comparison with the one-degree-of-freedom control system, it was confirmed that the control performance was improved by the two-degree-of-freedom control system that includes the observer.

  15. Workshop Physics Activity Guide, The Core Volume with Module 1: Mechanics I: Kinematics and Newtonian Dynamics (Units 1-7)

    NASA Astrophysics Data System (ADS)

    Laws, Priscilla W.

    2004-02-01

    The Workshop Physics Activity Guide is a set of student workbooks designed to serve as the foundation for a two-semester calculus-based introductory physics course. It consists of 28 units that interweave text materials with activities that include prediction, qualitative observation, explanation, equation derivation, mathematical modeling, quantitative experiments, and problem solving. Students use a powerful set of computer tools to record, display, and analyze data, as well as to develop mathematical models of physical phenomena. The design of many of the activities is based on the outcomes of physics education research.

  16. Are language-based activities in science effective for all students, including low achievers?

    NASA Astrophysics Data System (ADS)

    Rivard, Léonard P.

    2004-05-01

    The study investigated achievement status as a factor determining the use of language-based activities for learning science. A total of 154 eighth-grade students were randomly assigned to four groups, all stratified for gender and achievement level. The treatments involved various combinations of talk and writing, and descriptive and explanatory tasks. The dependent measures included scores on multiple choice tests obtained at three times during the study. Records of student talk and writing were also analyzed to identify patterns of differences between groups of achievers. The findings suggested that low achievers complete more problems, and develop better understanding and comprehension of ecology concepts when they have engaged in peer discussions of explanatory tasks. In comparison, high achievers benefit more from writing than talking, and writing explanations enhances comprehension more than restricted writing activities.

  17. Space-Based Astronomy: An Educator Guide with Activities for Science, Mathematics, and Technology Education

    NASA Technical Reports Server (NTRS)

    Vogt, Gregory L.

    2001-01-01

    If you go to the country, far from city lights, you can see about 3,000 stars on a clear night. If your eyes were bigger, you could see many more stars. With a pair of binoculars, an optical device that effectively enlarges the pupil of your eye by about 30 times, the number of stars you can see increases to the tens of thousands. With a medium-sized telescope with a light-collecting mirror 30 centimeters in diameter, you can see hundreds of thousands of stars. With a large observatory telescope, millions of stars become visible. This curriculum guide uses hands-on activities to help students and teachers understand the significance of space-based astronomy--astronomical observations made from outer space. It is not intended to serve as a curriculum. Instead, teachers should select activities from this guide that support and extend existing study. The guide contains few of the traditional activities found in many astronomy guides such as constellation studies, lunar phases, and planetary orbits. It tells, rather, the story of why it is important to observe celestial objects from outer space and how to study the entire electromagnetic spectrum. Teachers are encouraged to adapt these activities for the particular needs of their students. When selected activities from this guide are used in conjunction with traditional astronomy curricula, students benefit from a more complete experience.

  18. San Diego City Schools Speech Arts League Participation Guide: Rules and Regulations for Operation of Co-Curricular Speech Arts Activities. Fourth Edition.

    ERIC Educational Resources Information Center

    San Diego City Schools, CA.

    The fourth edition of a guide originally prepared in 1964, this publication is designed to meet the need for active competition among students of varying levels of experience in the areas of speech and drama. The co-curricular program outlined is designed for use as a supplement to senior high school instruction and activities. Included in the…

  19. Aeronautics: An Educator's Guide with Activities in Science, Mathematics, and Technology Education.

    ERIC Educational Resources Information Center

    National Aeronautics and Space Administration, Washington, DC.

    This educator's guide, developed for students in grades 2-4, discusses the field of aeronautics. It begins with education standards and skill matrices for the classroom activities, a description of the National Aeronautics and Space Administration (NASA) aeronautics mission, and a brief history of aeronautics. Activities are written for the…

  20. The Universal House: Energy, Shelter & The California Indian. Activity Guide, 4th/5th Grade.

    ERIC Educational Resources Information Center

    California Energy Extension Service, Sacramento.

    This activity guide links energy awareness with resource management and traditional California Indian cultures for the 3rd-6th grade span. The materials combine cooperative, hands-on activities with background information and learning extensions. The interdisciplinary lessons are built upon themes, concepts, and learning processes outlined in…

  1. A Guide to Staff Development Activities, Using a Florida Conference as a Model.

    ERIC Educational Resources Information Center

    Tuttle, Lester E., Jr., Ed.; Ciccone, Russell A., Ed.

    Staff development activities are the subject of a resource guide directed at educators of migrant children. One county participating in the Florida Migratory Child Compensatory Program was selected to serve as a model. Planning for activities should be individually-based, problem-oriented, goal-directed, time-factored, and participant-controlled.…

  2. Ocean Currents: Marine Science Activities for Grades 5-8. Teacher's Guide.

    ERIC Educational Resources Information Center

    Halversen, Catherine; Beals, Kevin; Strang, Craig

    This teacher's guide attempts to answer questions such as: What causes ocean currents? What impact do they have on Earth's environment? and How have they influenced human history? Seven innovative activities are provided in which students can gain fascinating insights into the earth as the ocean planet. Activities focus on how wind, temperature,…

  3. A Curriculum Activities Guide to Electric Power Generation and the Environment.

    ERIC Educational Resources Information Center

    Tully, Randolph R., Jr., Ed.

    This guide was developed by teachers involved in a workshop on "Electric Power Generation and the Environment." Activity topics are: (1) Energy and the Consumer; (2) Energy and Water Pollution; and (3) Energy and Air Pollution. Within these topics, the activities are classified as awareness level, transitional level, or operational level. Each…

  4. Rockets: A Teacher's Guide with Activities in Science, Mathematics, and Technology. Grades K-12.

    ERIC Educational Resources Information Center

    Shearer, Deborah A.; Vogt, Gregory L.

    This guide contains activities that emphasize hands-on involvement, prediction, data collection and interpretation, teamwork, and problem solving. It begins with background information on the history of rocketry, scientific principles, and practical rocketry. Following the background sections are a series of activities that demonstrate the basic…

  5. Environmental Resource Guide: Air Quality. A Series of Classroom Activities for Grades 6-8.

    ERIC Educational Resources Information Center

    Reed, Elizabeth W., Ed.

    Many different types of air quality can be studied in middle school science classes using available supplies. This grade 6-8 activity guide was developed to provide opportunities for children to learn about the issue of air quality. Sixteen hands-on activities integrate the issue into middle school science classes. A chart categorizes the…

  6. An Activities Supplement to the Curriculum Guide for Speech Communication--Grades 8-12.

    ERIC Educational Resources Information Center

    Lieb-Brilhart, Barbara, Comp.

    This curriculum activities supplement is the result of a graduate seminar at the University of Nebraska (Omaha), held in 1972. It is an addition to "A Curriculum Guide for Speech Communication--Grades 8-12," developed in 1971 (ED 066 776). The activities are structured according to the contract system, whereby each student selects his own projects…

  7. All "Trashed" Out: An Activity Guide to Solid Waste Management for Grades K-6.

    ERIC Educational Resources Information Center

    Illinois Univ., Springfield. Center for Solid Waste Management and Research, Springfield.

    This activity guide, specifically designed for Illinois classrooms but adaptable for other states, seeks to encourage primary students to make their own personal statement and responses to the environment through increased awareness of reducing, reusing, recycling, and composting of solid waste materials. The activities incorporate environmental…

  8. Green Thumbs: A Kid's Activity Guide to Indoor and Outdoor Gardening.

    ERIC Educational Resources Information Center

    Carlson, Laurie

    This guide contains indoor and outdoor gardening activities for children. The activities teach children how plants live and grow; how the weather, temperature, and seasons affect all living things; how living things come out of seeds and soil; how the birds, earthworms, bees, and toads help in the garden; and how the whole environment works…

  9. The Effectiveness of WhatsApp Mobile Learning Activities Guided by Activity Theory on Students' Knowledge Management

    ERIC Educational Resources Information Center

    Barhoumi, Chokri

    2015-01-01

    This research paper explores the effectiveness of using mobile technologies to support a blended learning course titled Scientific Research Methods in Information Science. Specifically, it discusses the effects of WhatsApp mobile learning activities guided by activity theory on students' knowledge Management (KM). During the 2014 academic year,…

  10. Should Cost-Effectiveness Analysis Include the Cost of Consumption Activities? AN Empirical Investigation.

    PubMed

    Adarkwah, Charles Christian; Sadoghi, Amirhossein; Gandjour, Afschin

    2016-02-01

    There has been a debate on whether cost-effectiveness analysis should consider the cost of consumption and leisure time activities when using the quality-adjusted life year as a measure of health outcome under a societal perspective. The purpose of this study was to investigate whether the effects of ill health on consumptive activities are spontaneously considered in a health state valuation exercise and how much this matters. The survey enrolled patients with inflammatory bowel disease in Germany (n = 104). Patients were randomized to explicit and no explicit instruction for the consideration of consumption and leisure effects in a time trade-off (TTO) exercise. Explicit instruction to consider non-health-related utility in TTO exercises did not influence TTO scores. However, spontaneous consideration of non-health-related utility in patients without explicit instruction (60% of respondents) led to significantly lower TTO scores. Results suggest an inclusion of consumption costs in the numerator of the cost-effectiveness ratio, at least for those respondents who spontaneously consider non-health-related utility from treatment. Results also suggest that exercises eliciting health valuations from the general public may include a description of the impact of disease on consumptive activities. PMID:25684073

  11. Antiviral activity of 1-docosanol, an inhibitor of lipid-enveloped viruses including herpes simplex.

    PubMed Central

    Katz, D H; Marcelletti, J F; Khalil, M H; Pope, L E; Katz, L R

    1991-01-01

    This article reports that 1-docosanol, a 22-carbon-long saturated alcohol, exerts a substantial inhibitory effect on replication of certain viruses (e.g., herpes simplex virus and respiratory syncytial virus) within primary target cells in vitro. To study the basis for its viral inhibitory activity, a suspension of 1-docosanol was formulated in an inert and nontoxic surfactant, Pluronic F-68; this suspension exerted potent inhibitory activity on the ability of susceptible viruses to infect cultured target cells. Susceptible viruses included wild-type herpes simplex viruses 1 and 2 as well as acyclovir-resistant herpes simplex virus 2 and also respiratory syncytial virus--all of which are lipid-enveloped. In contrast, nonenveloped poliovirus was not susceptible to the inhibitory action of 1-docosanol. Although the precise mechanism has yet to be defined, current evidence suggests that 1-docosanol inhibits viral replication by interfering with the early intracellular events surrounding viral entry into target cells. It is possible that interaction between the highly lipophilic compound and components of target cell membranes renders such target cells less susceptible to viral fusion and/or entry. If this mechanism proves to be correct, 1-docosanol may provide a broad spectrum activity against many different viruses, especially those with lipid-containing envelopes. Images PMID:1660151

  12. A Guide to Microsoft Active Directory (AD) Design

    SciTech Connect

    Dias, J

    2002-04-29

    The goal of this paper is to facilitate the design process for those DOE sites that are currently engaged in designing their Active Directory (AD) network. It is a roadmap to enable analysis of the complicated design tradeoffs associated with Active Directory Design. By providing discussion of Active Directory design elements which are permanent and costly to change once deployed, the hope is to minimize the risks of sponsoring failed designs, or joining existing infrastructures not suitable to programmatic needs. Specifically, most Active Directory structures will fall under one of three common designs: Single Domain, Single Forest with Multiple Domains, or Multiple Forests. Each has benefits and concerns, depending on programmatic and organizational structures. The comparison of these three approaches will facilitate almost any Active Directory design effort. Finally, this paper describes some best practices to consider when designing Active Directory based on three years of research and experience.

  13. 25 CFR 170.137 - What types of activities can a recreation, tourism, and trails program include?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... interpretative signs; (4) Provision for non-motorized trail activities including pedestrians and bicycles; (5) Provision for motorized trail activities including all terrain vehicles, motorcycles, snowmobiles, etc.; (6...; (8) Maintenance and restoration of existing recreational trails; (9) Development and...

  14. 25 CFR 170.137 - What types of activities can a recreation, tourism, and trails program include?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... interpretative signs; (4) Provision for non-motorized trail activities including pedestrians and bicycles; (5) Provision for motorized trail activities including all terrain vehicles, motorcycles, snowmobiles, etc.; (6...; (8) Maintenance and restoration of existing recreational trails; (9) Development and...

  15. 25 CFR 170.137 - What types of activities can a recreation, tourism, and trails program include?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... interpretative signs; (4) Provision for non-motorized trail activities including pedestrians and bicycles; (5) Provision for motorized trail activities including all terrain vehicles, motorcycles, snowmobiles, etc.; (6...; (8) Maintenance and restoration of existing recreational trails; (9) Development and...

  16. 25 CFR 170.137 - What types of activities can a recreation, tourism, and trails program include?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... interpretative signs; (4) Provision for non-motorized trail activities including pedestrians and bicycles; (5) Provision for motorized trail activities including all terrain vehicles, motorcycles, snowmobiles, etc.; (6...; (8) Maintenance and restoration of existing recreational trails; (9) Development and...

  17. Cell Cycle Regulators Guide Mitochondrial Activity in Radiation-Induced Adaptive Response

    PubMed Central

    Alexandrou, Aris T.

    2014-01-01

    Abstract Significance: There are accruing concerns on potential genotoxic agents present in the environment including low-dose ionizing radiation (LDIR) that naturally exists on earth's surface and atmosphere and is frequently used in medical diagnosis and nuclear industry. Although its long-term health risk is being evaluated and remains controversial, LDIR is shown to induce temporary but significant adaptive responses in mammalian cells and animals. The mechanisms guiding the mitochondrial function in LDIR-induced adaptive response represent a unique communication between DNA damage and cellular metabolism. Elucidation of the LDIR-regulated mitochondrial activity may reveal new mechanisms adjusting cellular function to cope with hazardous environmental stress. Recent Advances: Key cell cycle regulators, including Cyclin D1/CDK4 and Cyclin B1/cyclin-dependent kinase 1 (CDK1) complexes, are actively involved in the regulation of mitochondrial functions via phosphorylation of their mitochondrial targets. Accumulating new evidence supports a concept that the Cyclin B1/CDK1 complex acts as a mediator in the cross talk between radiation-induced DNA damage and mitochondrial functions to coordinate cellular responses to low-level genotoxic stresses. Critical Issues: The LDIR-mediated mitochondrial activity via Cyclin B1/CDK1 regulation is an irreplaceable network that is able to harmonize vital cellular functions with adjusted mitochondrial metabolism to enhance cellular homeostasis. Future Directions: Further investigation of the coordinative mechanism that regulates mitochondrial activities in sublethal stress conditions, including LDIR, will reveal new insights of how cells cope with genotoxic injury and will be vital for future targeted therapeutic interventions that reduce environmental injury and cancer risk. Antioxid. Redox Signal. 20, 1463–1480. PMID:24180340

  18. Earth's mysterious atmosphere. ATLAS 1: Teachers guide with activities

    NASA Technical Reports Server (NTRS)

    1991-01-01

    One of our mission's primary goals is to better understand the physics and chemistry of our atmosphere, the thin envelope of air that provides for human life and shields us from the harshness of space. The Space Shuttle Atlantis will carry the ATLAS 1 science instruments 296 km above Earth, so that they can look down into and through the various layers of the atmosphere. Five solar radiometers will precisely measure the amount of energy the Sun injects into Earth's environment. The chemistry at different altitudes will be measured very accurately by five other instruments called spectrometers. Much of our time in the cockpit of Atlantis will be devoted to two very exciting instruments that measure the auroras and the atmosphere's electrical characteristics. Finally, our ultraviolet telescope will probe the secrets of fascinating celestial objects. This Teacher's Guide is designed as a detective story to help you appreciate some of the many questions currently studied by scientists around the world. Many complex factors affect our atmosphere today, possibly even changing the course of global climate. All of us who live on Earth must recognize that we play an ever-growing role in causing some of these changes. We must solve this great atmospheric mystery if we are to understand all these changes and know what to do about them.

  19. Earth's mysterious atmosphere. ATLAS 1: Teachers guide with activities

    NASA Astrophysics Data System (ADS)

    1991-11-01

    One of our mission's primary goals is to better understand the physics and chemistry of our atmosphere, the thin envelope of air that provides for human life and shields us from the harshness of space. The Space Shuttle Atlantis will carry the ATLAS 1 science instruments 296 km above Earth, so that they can look down into and through the various layers of the atmosphere. Five solar radiometers will precisely measure the amount of energy the Sun injects into Earth's environment. The chemistry at different altitudes will be measured very accurately by five other instruments called spectrometers. Much of our time in the cockpit of Atlantis will be devoted to two very exciting instruments that measure the auroras and the atmosphere's electrical characteristics. Finally, our ultraviolet telescope will probe the secrets of fascinating celestial objects. This Teacher's Guide is designed as a detective story to help you appreciate some of the many questions currently studied by scientists around the world. Many complex factors affect our atmosphere today, possibly even changing the course of global climate. All of us who live on Earth must recognize that we play an ever-growing role in causing some of these changes. We must solve this great atmospheric mystery if we are to understand all these changes and know what to do about them.

  20. Earth's mysterious atmosphere. ATLAS 1: Teachers guide with activities

    SciTech Connect

    Not Available

    1991-11-01

    One of our mission's primary goals is to better understand the physics and chemistry of our atmosphere, the thin envelope of air that provides for human life and shields us from the harshness of space. The Space Shuttle Atlantis will carry the ATLAS 1 science instruments 296 km above Earth, so that they can look down into and through the various layers of the atmosphere. Five solar radiometers will precisely measure the amount of energy the Sun injects into Earth's environment. The chemistry at different altitudes will be measured very accurately by five other instruments called spectrometers. Much of our time in the cockpit of Atlantis will be devoted to two very exciting instruments that measure the auroras and the atmosphere's electrical characteristics. Finally, our ultraviolet telescope will probe the secrets of fascinating celestial objects. This Teacher's Guide is designed as a detective story to help you appreciate some of the many questions currently studied by scientists around the world. Many complex factors affect our atmosphere today, possibly even changing the course of global climate. All who live on Earth must recognize that they play an ever-growing role in causing some of these changes. People must solve this great atmospheric mystery if they are to understand all these changes and know what to do about them.

  1. Prostate segmentation with local binary patterns guided active appearance models

    NASA Astrophysics Data System (ADS)

    Ghose, Soumya; Oliver, Arnau; Martí, Robert; Lladó, Xavier; Freixenet, Jordi; Vilanova, Joan C.; Meriaudeau, Fabrice

    2011-03-01

    Real-time fusion of Magnetic Resonance (MR) and Trans Rectal Ultra Sound (TRUS) images aid in the localization of malignant tissues in TRUS guided prostate biopsy. Registration performed on segmented contours of the prostate reduces computational complexity and improves the multimodal registration accuracy. However, accurate and computationally efficient segmentation of the prostate in TRUS images could be challenging in the presence of heterogeneous intensity distribution inside the prostate gland, and other imaging artifacts like speckle noise, shadow regions and low Signal to Noise Ratio (SNR). In this work, we propose to enhance the texture features of the prostate region using Local Binary Patterns (LBP) for the propagation of a shape and appearance based statistical model to segment the prostate in a multi-resolution framework. A parametric model of the propagating contour is derived from Principal Component Analysis (PCA) of the prior shape and texture information of the prostate from the training data. The estimated parameters are then modified with the prior knowledge of the optimization space to achieve an optimal segmentation. The proposed method achieves a mean Dice Similarity Coefficient (DSC) value of 0.94+/-0.01 and a mean segmentation time of 0.68+/-0.02 seconds when validated with 70 TRUS images of 7 datasets in a leave-one-patient-out validation framework. Our method performs computationally efficient and accurate prostate segmentation in the presence of intensity heterogeneities and imaging artifacts.

  2. Conservation II. Science Activities in Energy. [Student's and] Teacher's Guide.

    ERIC Educational Resources Information Center

    Oak Ridge Associated Universities, TN.

    Designed for science students in fourth, fifth, and sixth grades, the activities in this unit illustrate principles and problems related to the conservation of energy. Eleven student activities using art, economics, arithmetic, and other skills and disciplines help teachers directly involve students in exploring scientific questions and making…

  3. A Curriculum Activities Guide to Solid Waste and Environmental Studies.

    ERIC Educational Resources Information Center

    Hershey, John T., Ed.; And Others

    This book is the first in a series of four books emphasizing student-oriented problem solving related to environmental matters. It is divided into three activity levels: awareness, transitional, and operational. The activity sequence is designed to motivate students toward a concern for environmental quality, take action related to particular…

  4. Biomass I. Science Activities in Energy [and] Teacher's Guide.

    ERIC Educational Resources Information Center

    Oak Ridge Associated Universities, TN.

    Designed for science students in fourth, fifth, and sixth grades, the activities in this unit illustrate principles and problems related to biomass as a form of energy. (The word biomass is used to describe all solid material of animal or vegetable origin from which energy may be extracted.) Twelve student activities using art, economics,…

  5. A Curriculum Activities Guide to Population and Environmental Studies.

    ERIC Educational Resources Information Center

    Hershey, John T., Ed.; And Others

    This book is the second in a series of four books emphasizing student-oriented problem solving related to environmental matters. It is divided into three activity levels: awareness, transitional, and operational. The activity sequence is designed to motivate students toward a concern for environmental quality, take action related to particular…

  6. Workshop Physics Activity Guide, Module 2: Mechanics II, Momentum, Energy, Rotational and Harmonic Motion, and Chaos (Units 8 - 15)

    NASA Astrophysics Data System (ADS)

    Laws, Priscilla W.

    2004-05-01

    The Workshop Physics Activity Guide is a set of student workbooks designed to serve as the foundation for a two-semester calculus-based introductory physics course. It consists of 28 units that interweave text materials with activities that include prediction, qualitative observation, explanation, equation derivation, mathematical modeling, quantitative experiments, and problem solving. Students use a powerful set of computer tools to record, display, and analyze data, as well as to develop mathematical models of physical phenomena. The design of many of the activities is based on the outcomes of physics education research. The Workshop Physics Activity Guide is supported by an Instructor's Website that: (1) describes the history and philosophy of the Workshop Physics Project; (2) provides advice on how to integrate the Guide into a variety of educational settings; (3) provides information on computer tools (hardware and software) and apparatus; and (4) includes suggested homework assignments for each unit. Log on to the Workshop Physics Project website at http://physics.dickinson.edu/ Workshop Physics is a component of the Physics Suite--a collection of materials created by a group of educational reformers known as the Activity Based Physics Group. The Physics Suite contains a broad array of curricular materials that are based on physics education research, including:

      Understanding Physics, by Cummings, Laws, Redish and Cooney (an introductory textbook based on the best-selling text by Halliday/Resnick/Walker) RealTime Physics Laboratory Modules Physics by Inquiry (intended for use in a workshop setting) Interactive Lecture Demonstration Tutorials in Introductory Physics Activity Based Tutorials (designed primarily for use in recitations)

    • Exploring the Moon: A teacher's guide with activities for Earth and space sciences

      NASA Technical Reports Server (NTRS)

      Taylor, G. Jeffrey; Martel, Linda M. V.; Bays, Brooks G., Jr.

      1994-01-01

      This guide contains educational materials designed for use in upper elementary through high schools with the Lunar Sample Disk. A set of thirty-six 35-mm slides complements the activities in this guidebook. The book contains: (1) information on the Lunar Sample Disk; (2) a curriculum content matrix; (3) a teacher's guide; (4) moon ABC's fact sheet; (5) rock ABC's fact sheet; (6) progress in Lunar Science chart; (7) seventeen activities; (8) a resource section for each unit; (9) a glossary; and (10) a list of NASA educational resources.

    • Monitoring active volcanoes and mitigating volcanic hazards: the case for including simple approaches

      NASA Astrophysics Data System (ADS)

      Stoiber, Richard E.; Williams, Stanley N.

      1990-07-01

      Simple approaches to problems brought about eruptions and their ensuing hazardous effects should be advocated and used by volcanologists while awaiting more sophisticated remedies. The expedients we advocate have all or many of the following attributes: only locally available materials are required; no extensive training of operators or installation is necessary; they are affordable and do not require foreign aid or exports; they are often labor intensive and are sustainable without outside assistance. Where appropriate, the involvement of local residents is advocated. Examples of simple expedients which can be used in forecasting or mitigating the effects of crises emphasize the relative ease and the less elaborate requirements with which simple approaches can be activated. Emphasis is on visual observations often by untrained observers, simple meteorogical measurements, observations of water level in lakes, temperature and chemistry of springs and fumaroles, new springs and collapse areas and observations of volcanic plumes. Simple methods are suggested which can be applied to mitigating damage from mudflows, nuées ardentes, tephra falls and gas discharge. A review in hindsight at Ruiz includes the use of both chemical indicators and simple mudflow alarms. Simple expedients are sufficiently effective that any expert volcanologist called to aid in a crisis must include them in the package of advice offered. Simple approaches are a critical and logical complement to highly technical solutions to hazardous situations.

    • Your Guide to Physical Activity and Your Heart

      MedlinePlus

      ... Physical Activity Calories Burned per Hour Hiking Light gardening/yard work Dancing Golf (walking and carrying clubs) ... Bicycling (less than 10 mph) Downhill skiing Dancing Gardening Golf (on foot) Hiking (flat ground) Horseback riding ...

    • Which Book and Why: Using Book Bands and Book Levels for Guided Reading in Key Stage 1 [Includes CD-ROM

      ERIC Educational Resources Information Center

      Bodman, Sue, Ed.; Franklin, Glen, Ed.

      2014-01-01

      We want all children to love reading, and Which Book and Why demonstrates how effective guided reading for children in Foundation Stage and Key Stage 1 can help teachers make this happen. Balancing theory and practice, this book explores how schools and teachers can implement guided reading more confidently and more effectively. Which Book and Why…

    • Trypanocidal Activity of Smallanthus sonchifolius: Identification of Active Sesquiterpene Lactones by Bioassay-Guided Fractionation

      PubMed Central

      Frank, F. M.; Ulloa, J.; Cazorla, S. I.; Maravilla, G.; Malchiodi, E. L.; Grau, A.; Martino, V.; Catalán, C.; Muschietti, L. V.

      2013-01-01

      In order to find novel plant-derived biologically active compounds against Trypanosoma cruzi, we isolated, from the organic extract of Smallanthus sonchifolius, the sesquiterpene lactones enhydrin (1), uvedalin (2), and polymatin B (3) by bioassay-guided fractionation technique. These compounds showed a significant trypanocidal activity against the epimastigote forms of the parasite with IC50 values of 0.84 μM (1), 1.09 μM (2), and 4.90 μM (3). After a 24 h treatment with 10 μg/mL of enhydrin or uvedalin, parasites were not able to recover their replication rate. Compounds 1 and 2 showed IC50 values of 33.4 μM and 25.0 μM against T. cruzi trypomastigotes, while polymatin B was not active. When the three compounds were tested against the intracellular forms of T. cruzi, they were able to inhibit the amastigote replication with IC50 of 5.17 μM, 3.34 μM, and 9.02 μM for 1, 2, and 3, respectively. The cytotoxicity of the compounds was evaluated in Vero cells obtaining CC50 values of 46.5 μM (1), 46.8 μM (2), and 147.3 μM (3) and the selectivity index calculated. According to these results, enhydrin and uvedalin might have potentials as agents against Chagas disease and could serve as lead molecules to develop new drugs. PMID:23840260

    • Be BOLD: Encouraging Girls to Include Unstructured Bouts of Physical Activity into Daily Routines

      ERIC Educational Resources Information Center

      Hill, Kory; Williams, Gwynne M.

      2014-01-01

      Adolescent girls are less active than their male counterparts and physical activity levels tend to decline as one ages. One of the goals of concerned physical educators is to promote a physically active lifestyle and to teach skills and promote behaviors that will allow students to be active both in and out of school. This article presents a…

    • Social competence and collaborative guided inquiry science activities: Experiences of students with learning disabilities

      NASA Astrophysics Data System (ADS)

      Taylor, Jennifer Anne

      This thesis presents a qualitative investigation of the effects of social competence on the participation of students with learning disabilities (LD) in the science learning processes associated with collaborative, guided inquiry learning. An inclusive Grade 2 classroom provided the setting for the study. Detailed classroom observations were the primary source of data. In addition, the researcher conducted two interviews with the teacher, and collected samples of students' written work. The purpose of the research was to investigate: (a) How do teachers and peers mediate the participation of students with LD in collaborative, guided inquiry science activities, (b) What learning processes do students with LD participate in during collaborative, guided inquiry science activities, and (c) What components of social competence support and constrain the participation of students with LD during collaborative, guided inquiry science activities? The findings of the study suggest five key ideas for research and teaching in collaborative, guided inquiry science in inclusive classrooms. First, using a variety of collaborative learning formats (whole-class, small-group, and pairs) creates more opportunities for the successful participation of diverse students with LD. Second, creating an inclusive community where students feel accepted and valued may enhance the academic and social success of students with LD. Third, careful selection of partners for students with LD is important for a positive learning experience. Students with LD should be partnered with academically successful, socially competent peers; also, this study suggested that students with LD experience more success working collaboratively in pairs rather than in small groups. Fourth, a variety of strategies are needed to promote active participation and positive social interactions for students with and without LD during collaborative, guided inquiry learning. Fifth, adopting a general approach to teaching

    • An Art Activity Guide for Teachers of Severely Handicapped.

      ERIC Educational Resources Information Center

      Burst, Judy; And Others

      This manual presents 48 visual art activities developed for severely disabled elementary and secondary school students. Brief explanations are presented for several handicapping conditions (cerebral palsy, Down's Syndrome, microcephaly, hydrocephaly, and communication handicaps), and information is given for positioning of students and…

    • Using Guided, Corpus-Aided Discovery to Generate Active Learning

      ERIC Educational Resources Information Center

      Huang, Li-Shih

      2008-01-01

      Over the years, educators have proposed a variety of active learning pedagogical approaches that focus on encouraging students to discover for themselves the principles and solutions that will engage them in learning and enhance their educational outcomes. Among these approaches are problem-based, inquiry-based, experiential, and discovery…

    • Animals Alive! An Ecological Guide to Animal Activities.

      ERIC Educational Resources Information Center

      Holley, Dennis

      Animals Alive! is designed to help teachers develop an inquiry-oriented program for studying the animal kingdom in which, whenever possible, live animals are collected locally, studied, observed, and then released completely unharmed back into their natural habitats. By careful selection and modification of the chapter questions, activities, and…

    • Be Active Your Way: A Guide for Adults

      MedlinePlus

      ... you will try): ❑ Biking slowly ❑ Canoeing ❑ Dancing ❑ General gardening (raking, trimming shrubs) ❑ Tennis (doubles) ❑ Using your manual ... activities a couple of days a week: • Heavy gardening (digging,shoveling) • Lifting weights • Push-ups on the ...

    • Measurement for Work. Teaching Guide and Sample Learning Activities.

      ERIC Educational Resources Information Center

      Angel, Margo; Bolton, Chris

      This document is intended to help Australian technical and further education instructors in New South Wales (TAFE NSW) identify teaching principles and learning activities that they can use to help adult learners master the mathematics processes, knowledge, and skills needed to perform basic measurement tasks in today's workplace. The materials…

    • Activities for Teaching Positive Psychology: A Guide for Instructors

      ERIC Educational Resources Information Center

      Froh, Jeffrey J., Ed.; Parks, Acacia C., Ed.

      2012-01-01

      Positive psychology is a rapidly expanding area of study that is of great interest to students at the graduate, undergraduate, and high school levels. But the field is so broad that teachers who want to cover all the bases when designing a positive psychology course may have difficulty locating and selecting materials. "Activities for Teaching…

    • Wilbur and Orville Wright. Curriculum Guide [and] Activity Booklet.

      ERIC Educational Resources Information Center

      Federal Aviation Administration (DOT), Washington, DC.

      This learning packet contains information about the Wright Brothers, Wilbur and Orville. The packet highlights certain facts that will help students understand the Wright Brothers' contributions in the field of manned flight in a heavier-than-air machine. It includes poster sheets (artwork) and task cards to be used by students and a booklet to…

  1. ENGAGE: Guided Activity-Based Gaming in Neurorehabilitation after Stroke: A Pilot Study

    PubMed Central

    Reinthal, Ann; Szirony, Kathy; Clark, Cindy; Swiers, Jeffrey; Kellicker, Michelle; Linder, Susan

    2012-01-01

    Introduction. Stroke is a leading cause of disability in healthy adults. The purpose of this pilot study was to assess the feasibility and outcomes of a novel video gaming repetitive practice paradigm, (ENGAGE) enhanced neurorehabilitation: guided activity-based gaming exercise. Methods. Sixteen individuals at least three months after stroke served as participants. All participants received concurrent outpatient therapy or took part in a stroke exercise class and completed at least 500 minutes of gaming. Primary baseline and posttest outcome measures included the Wolf motor function test (WMFT) and the Fugl-Meyer assessment (FMA). ENGAGE uses a game selection algorithm providing focused, graded activity-based repetitive practice that is highly individualized and directed. The Wilcoxon signed ranks test was used to determine statistical significance. Results. There were improvements in the WMFT (P = 0.003) and the FMA (P = 0.002) that exceeded established values of minimal clinically important difference. Conclusions. ENGAGE was feasible and an effective adjunct to concurrent therapy after stroke. PMID:22593835

  2. T & I--Small Appliance Repair. Kit No. 30. Instructor's Manual [and] Student Learning Activity Guide.

    ERIC Educational Resources Information Center

    Peterson, Ken

    An instructor's manual and student activity guide on small appliance repair are provided in this set of prevocational education materials which focuses on the vocational area of trade and industry. (This set of materials is one of ninety-two prevocational education sets arranged around a cluster of seven vocational offerings: agriculture, home…

  3. Microgravity: A Teacher's Guide with Activities in Science, Mathematics, and Technology. Grades 5-12.

    ERIC Educational Resources Information Center

    Rogers, Melissa J. B.; Vogt, Gregory L.; Wargo, Michael J.

    This teacher's guide explains microgravity, provides information on the history of microgravity, the domains of microgravity research and introduces classroom activities. Among the contents are the following: (1) "First, What Is Gravity?"; (2) "What Is Microgravity?"; (3) "Creating Microgravity"; (4) "The Microgravity Environment of Orbiting…

  4. Partners against Hate Program Activity Guide: Helping Children Resist Bias and Hate.

    ERIC Educational Resources Information Center

    Wotorson, Michael

    This guide provides parents, educators, and other adults with tools and strategies to engage in constructive discussions and activities about the causes and effects of prejudice and bias-motivated behavior and to intervene when needed with children who engage in such behavior. Though it targets elementary school, much of the material is relevant…

  5. Health Occupations--Operating Room Technician. Kit No. 63. Instructor's Manual [and] Student Learning Activity Guide.

    ERIC Educational Resources Information Center

    Jackson, Janette

    An instructor's manual and student activity guide on the operating room technician are provided in this set of prevocational education materials which focuses on the vocational area of health occupations. (This set of materials is one of ninety-two prevocational education sets arranged around a cluster of seven vocational offerings: agriculture,…

  6. An Activity Guide for Teachers: Everglades National Park. Grades 4-6.

    ERIC Educational Resources Information Center

    De Jong, Neil, Comp.

    Everglades National Park is recognized as one of the most threatened National Parks in the country. Human and technological intervention has affected the park's water resources, fauna and flora through the introduction of foreign species. This curriculum-based activity guide is intended for intermediate grade students. It has been designed from a…

  7. Health Occupations--Nursing Assistant, Wheelchair. Kit No. 58. Instructor's Manual [and] Student Learning Activity Guide.

    ERIC Educational Resources Information Center

    Brown, Annie T.

    An instructor's manual and student activity guide on the nursing assistant--assisting patients in using the wheelchair are provided in this set of prevocational education materials which focuses on the vocational area of health occupations. (This set of materials is one of ninety-two prevocational education sets arranged around a cluster of seven…

  8. Health Occupations--Practical Nurse. Kit No. 45. Instructor's Manual [and] Student Learning Activity Guide.

    ERIC Educational Resources Information Center

    Jackson, Janette

    An instructor's manual and student activity guide on practical nursing are provided in this set of prevocational education materials which focuses on the vocational area of health occupations. (This set of materials is one of ninety-two prevocational education sets arranged around a cluster of seven vocational offerings: agriculture, home…

  9. T & I--Masonry. Kit No. 10. Instructor's Manual [and] Student Learning Activity Guide.

    ERIC Educational Resources Information Center

    Poston, Paul

    An instructor's manual and student activity guide on masonry are provided in this set of prevocational education materials which focuses on the vocational area of trade and industry. (This set of materials is one of ninety-two prevocational education sets arranged around a cluster of seven vocational offerings: agriculture, home economics,…

  10. T & I--Cosmetology, Skin Care. Kit No. 77. Instructor's Manual [and] Student Learning Activity Guide.

    ERIC Educational Resources Information Center

    Terry, Carolyn

    An instructor's manual and student activity guide on skin care are provided in this set of prevocational education materials which focuses on the vocational area of trade and industry (cosmetology). (This set of materials is one of ninety-two prevocational education sets arranged around a cluster of seven vocational offerings: agriculture, home…

  11. Office Occupations--Business Communications. Kit No. 20. Instructor's Manual [and] Student Learning Activity Guide.

    ERIC Educational Resources Information Center

    Campbell, Creola S.

    An instructor's manual and student activity guide on business communications are provided in this set of prevocational education materials which focuses on the vocational area of office occupations. (This set of materials is one of ninety-two prevocational education sets arranged around a cluster of seven vocational offerings: agriculture, home…

  12. Exploring the Moon: A Teacher's Guide with Activities for Earth and Space Sciences.

    ERIC Educational Resources Information Center

    National Aeronautics and Space Administration, Washington, DC.

    This educational guide concerns exploring the moon. Activities are divided into three units: Pre-Apollo, Learning from Apollo, and The Future. These correspond, at least roughly, to exercises that can be done before the Lunar Sample Disk (available from NASA) arrives to the school (Pre-Apollo), while it is there (Learning from Apollo), and after…

  13. Acid Rain: A Teacher's Guide. Activities for Grades 4 to 12.

    ERIC Educational Resources Information Center

    National Wildlife Federation, Washington, DC.

    This guide on acid rain for elementary and secondary students is divided into three study areas: (1) What Causes Acid Rain; (2) What Problems Acid Rain Has Created; (3) How You and Your Students Can Help Combat Acid Rain. Each section presents background information and a series of lessons pertaining to the section topic. Activities include…

  14. CHAD USER’S GUIDE: Extracting Human Activity Information from CHAD on the PC

    EPA Science Inventory

    The Consolidated Human Activity Database (CHAD) User Guide offers a short tutorial about CHAD Access; background on the CHAD Databases; background on individual studies in CHAD; and information about using CHAD data, caveats, known problems, notes, and database design and develop...

  15. Agriculture--Horticulture. Kit No. 36. Instructor's Manual [and] Student Learning Activity Guide.

    ERIC Educational Resources Information Center

    Smith, Claudia

    An instructor's manual and student activity guide on horticulture are provided in this set of prevocational education materials which focus on the vocational area of agriculture. (This set of materials is one of ninety-two prevocational education sets arranged around a cluster of seven vocational offerings: agriculture, home economics,…

  16. Home Economics--Child Care Services. Kit No. 24. Instructor's Manual [and] Student Learning Activity Guide.

    ERIC Educational Resources Information Center

    Underwood, Earl

    An instructor's manual and student activity guide on child care services are provided in this set of prevocational education materials which focuses on the vocational area of home economics. (This set of materials is one of ninety-two prevocational education sets arranged around a cluster of seven vocational offerings: agriculture, home economics,…

  17. A Teacher's Activities Guide for Chinese New Year - Gung Hei Fat Choy.

    ERIC Educational Resources Information Center

    Sonoma County Superintendent of Schools, Santa Rosa, CA.

    This teacher's guide is designed to provide information and activities on the Chinese New Year and on aspects of the culture and heritage of the Chinese-American. Background material is given on the history of Chinese immigration to America, the lunar calendar, the Chinese cycle of years, the Chinese zodiac, the philosophical concept of yin and…

  18. Suited for Spacewalking. Teacher's Guide with Activities for Physical and Life Science. Revised.

    ERIC Educational Resources Information Center

    Vogt, Gregory L.

    This activity guide for teachers interested in using the intense interest many children have in space exploration as a launching point for exciting hands-on learning opportunities begins with brief discussions of the space environment, the history of spacewalking, the Space Shuttle spacesuit, and working in space. These are followed by a series of…

  19. Office Occupations--General Clerical. Kit No. 12. Instructor's Manual [and] Student Learning Activity Guide.

    ERIC Educational Resources Information Center

    Campbell, Creola S.

    An instructor's manual and student activity guide on general clerical work are provided in this set of prevocational education materials which focuses on the vocational area of office occupations. (This set of materials is one of ninety-two prevocational education sets arranged around a cluster of seven vocational offerings: agriculture, home…

  20. T & I--Gas Welding. Kit No. 68. Instructor's Manual [and] Student Learning Activity Guide.

    ERIC Educational Resources Information Center

    Lanford, Frank

    An instructor's manual and student activity guide on gas welding are provided in this set of prevocational education materials which focuses on the occupational cluster of trade and industry. (This set of materials is one of ninety-two prevocational education sets arranged around a cluster of seven vocational offerings: agriculture, home…

  1. T & I--Plumbing. Kit No. 67. Instructor's Manual [and] Student Learning Activity Guide.

    ERIC Educational Resources Information Center

    Lanford, Frank

    An instructor's manual and student activity guide on plumbing are provided in this set of prevocational education materials which focuses on the vocational area of trade and industry. (This set of materials is one of ninety-two prevocational education sets arranged around a cluster of seven vocational offerings: agriculture, home economics,…

  2. T & I--Electricity. Power. Kit No. 52. Instructor's Manual [and] Student Learning Activity Guide.

    ERIC Educational Resources Information Center

    Jones, Phillip

    An instructor's manual and student activity guide on electrical power are provided in this set of prevocational education materials which focuses on the vocational area of trade and industry. (This set of materials is one of ninety-two prevocational education sets arranged around a cluster of seven vocational offerings: agriculture, home…

  3. Comet Kohoutek, 1973-1974, A Teachers' Guide with Student Activities.

    ERIC Educational Resources Information Center

    Chapman, Robert D.

    This teacher's guide provides background information, curriculum source materials, and suggested class activities for class discussion and study. Information related to the discovery of the comet is presented as well as photographic and schematic pictures showing the sky through which the comet travels. Historical data regarding comets of the past…

  4. T & I--Painting and Decorating. Kit No. 5. Instructor's Manual [and] Student Learning Activity Guide.

    ERIC Educational Resources Information Center

    Lanford, Frank

    An instructor's manual and student activity guide on painting and decorating are provided in this set of prevocational education materials which focuses on the vocational area of trade and industry. (This set of materials is one of ninety-two prevocational education sets arranged around a cluster of seven vocational offerings: agriculture, home…

  5. T & I--Brick Masonry II. Kit No. 80. Instructor's Manual [and] Student Learning Activity Guide.

    ERIC Educational Resources Information Center

    Steele, Lloyd

    An instructor's manual and student activity guide on brick masonry II are provided in this set of prevocational education materials which focuses on the vocational area of trade and industry. (This set of materials is one of ninety-two prevocational education sets arranged around a cluster of seven vocational offerings: agriculture, home…

  6. Health Occupations--Dental Assistant. Kit No. 62. Instructor's Manual [and] Student Learning Activity Guide.

    ERIC Educational Resources Information Center

    Jackson, Janette

    An instructor's manual and student activity guide on a dental assistant are provided in this set of prevocational education materials which focuses on the vocational area of health occupations. (This set of materials is one of ninety-two prevocational education sets arranged around a cluster of seven vocational offerings: agriculture, home…

  7. Cosmetology. Kit No. 3. Instructor's Manual [and] Student Learning Activity Guide.

    ERIC Educational Resources Information Center

    Wilkins, Thelma

    An instructor's manual and student activity guide on cosmetology are provided in this set of prevocational education materials which focuses on the vocational area of trade and industry. (This set of materials is one of ninety-two prevocational education sets arranged around a cluster of seven vocational offerings: agriculture, home economics,…

  8. Laser active imaging-guided anti-tank missile system small-scale integration design

    NASA Astrophysics Data System (ADS)

    Yan, Mingliang; Shan, Xiangqian; Qu, Zhou

    2010-10-01

    At present, the domestic and international third-generation anti-tank missiles, laser-guided missiles are mostly divided into active laser-guided and laser semi-active guidance, this guidance system, there are vulnerable to electronic interference, can not be fully realized after launching deficiencies. Article based on this, an in-depth understanding of imaging-guided laser-active working principle, based on the pairs of third-generation anti-tank missile guidance system, boldly proposed to improve the anti-tank missiles, laser-active small-scale integration of imaging guidance system design, the main purpose is to improve a certain type of The optical target missile, TV angle measurement, laser-guided instruction transmission means, so that anti-tank missiles to achieve forward-looking, the next obstacle avoidance TV and multi-functional integration of the entire after launching smart missiles, and in theory be able to study the new antitank missiles play a certain reference.

  9. Agriculture--Agricultural Sales and Service. Kit No. 21. Instructor's Manual [and] Student Learning Activity Guide.

    ERIC Educational Resources Information Center

    Caines, Royce

    An instructor's manual and student activity guide on agricultural sales and service are provided in this set of prevocational education materials which focuses on the vocational area of agriculture. (This set of materials is one of ninety-two prevocational education sets arranged around a cluster of seven vocational offerings: agriculture, home…

  10. Using Activity Theory and its Principle of Contradictions to Guide Research in Educational Technology

    ERIC Educational Resources Information Center

    Murphy, Elizabeth; Rodriguez-Manzanares, Maria A.

    2008-01-01

    This paper describes how activity theory (AT) and its principle of contradictions may be relied on to guide research in educational technology. The paper begins with a theoretical overview of AT and of its principle of contradictions. It follows with a synthesis of studies that have used AT as a lens to study information and communication…

  11. Earth Science Activities: A Guide to Effective Elementary School Science Teaching.

    ERIC Educational Resources Information Center

    Kanis, Ira B.; Yasso, Warren E.

    The primary emphasis of this book is on new or revised earth science activities that promote concept development rather than mere verification of concepts learned by passive means. Chapter 2 describes philosophies, strategies, methods, and techniques to guide preservice and inservice teachers, school building administrators, and curriculum…

  12. Health Occupations--Respiration Therapy Technician. Kit No. 66. Instructor's Manual [and] Student Learning Activity Guide.

    ERIC Educational Resources Information Center

    Jackson, Janette

    An instructor's manual and student activity guide on respiration therapy technician are provided in this set of prevocational education materials which focuses on the vocational area of health occupations. (This set of materials is one of ninety-two prevocational education sets arranged around a cluster of seven vocational offerings: agriculture,…

  13. Assisting in the Medical Laboratory. Instructor's Guide, Students' Manual, and Student Learning Activities.

    ERIC Educational Resources Information Center

    Fair, Helena J.

    The instructor's guide, the first of three documents in this package, is for a course to help students who are investigating the activities within a hospital, clinic, or physician's office. The material is designed to relate training experience to information studied in the classroom. The course is intended for individualized study and is…

  14. Office Occupations--Clerical--Calculators. Kit No. 75. Instructor's Manual [and] Student Learning Activity Guide.

    ERIC Educational Resources Information Center

    Stewart, Ada

    An instructor's manual and student activity guide on the clerical use of calculators are provided in this set of prevocational education materials which focuses on the vocational area of office occupations. (This set of materials is one of ninety-two prevocational education sets arranged around a cluster of seven vocational offerings: agriculture,…

  15. Working in Pharmacies. Instructor's Guide. Student's Manual. Student Learning Activities. Second Revised Edition.

    ERIC Educational Resources Information Center

    Driever, Carl W.; And Others

    This document combines three separately bound volumes, a student manual, an instructor's guide, and student learning activities designed for students who are either in beginning-level pharmacy technician courses or considering careers in pharmacy. The material is intended to relate training experience to information studied in the classroom. The…

  16. Cabinetmaking. Kit No. 13. Instructor's Manual [and] Student Learning Activity Guide.

    ERIC Educational Resources Information Center

    Gull, Gaynell

    An instructor's manual and student activity guide on cabinetmaking are provided in this set of prevocational education materials which focuses on the vocational area of trade and industry. (This set of materials is one of ninety-two prevocational education sets arranged around a cluster of seven vocational offerings: agriculture, home economics,…

  17. Marketing Education Assessment Guide. Performance-Based Activities with Authentic Assessments Instruments.

    ERIC Educational Resources Information Center

    Everett, Donna R.

    This guide presents performance-based authentic assessment ideas, samples, and suggestions to help marketing teachers and students respond to changes and pressures from outside the classroom. It contains 21 activities, each accompanied by a method of authentic assessment. In most cases, the authentic assessment method is a scoring device. The…

  18. T & I, Power Mechanics. Kit No. 35. Instructor's Manual [and] Student Learning Activity Guide.

    ERIC Educational Resources Information Center

    Underwood, Earl

    An instructor's manual and student activity guide on power mechanics are provided in this set of prevocational education materials which focuses on the vocational area of trade and industry. (This set of materials is one of ninety-two prevocational education sets arranged around a cluster of seven vocational offerings: agriculture, home economics,…

  19. A Curriculum Activities Guide to Water Pollution Equipment and Environmental Studies, Volume 3.

    ERIC Educational Resources Information Center

    Hershey, John T., Ed.; And Others

    The purpose of this guidebook is to present instructions for constructing low-cost instruments for environmental studies. The instruments discussed were either adopted or designed by students who were presented with the problem of producing low-cost environmental monitoring equipment. This book is a sequel to A Curriculum Activities Guide to Water…

  20. The Dynamic Density Bottle: A Make-and-Take, Guided Inquiry Activity on Density

    ERIC Educational Resources Information Center

    Kuntzleman, Thomas S.

    2015-01-01

    An activity is described wherein students observe dynamic floating and sinking behavior of plastic pieces in various liquids. The liquids and solids are all contained within a plastic bottle; the entire assembly is called a "density bottle". After completing a series of experiments that guides students to think about the relative…

  1. T & I--Auto Service Repair. Kit No. 14. Instructor's Manual [and] Student Learning Activity Guide.

    ERIC Educational Resources Information Center

    Jones, Phillip

    An instructor's manual and student activity guide on auto service repair are provided in this set of prevocational education materials which focuses on the vocational area of trade and industry. (This set of materials is one of ninety-two prevocational education sets arranged around a cluster of seven vocational offerings: agriculture, home…

  2. T & I--Graphics, Rubber Stamp. Kit No. 90. Instructor's Manual [and] Student Learning Activity Guide.

    ERIC Educational Resources Information Center

    Lake, Robert J.

    An instructor's manual and student activity guide on making a rubber stamp are provided in this set of prevocational education materials which focuses on the vocational area of trade and industry (graphics). (This set of materials is one of ninety-two prevocational education sets arranged around a cluster of seven vocational offerings:…

  3. Team Nutrition School Activity Planner. A How-To Guide for Team Nutrition Schools and Supporters.

    ERIC Educational Resources Information Center

    Food and Consumer Service (USDA), Washington, DC.

    This "how-to" guide for Team Nutrition fairs and tasting activities helps Team Nutrition supporters and schools understand how to work together to improve the health and education of children. Team Nutrition is the implementation tool for the U.S. Department of Agriculture's School Meals Initiative for Healthy Children. Section 1 of the guide…

  4. T & I--Basic Electricity. Kit No. 4. Instructor's Manual [and] Student Learning Activity Guide.

    ERIC Educational Resources Information Center

    Underwood, Earl

    An instructor's manual and student activity guide on basic electricity are provided in this set of prevocational education materials which focuses on the vocational area of trade and industry. (This set of materials is one of ninety-two prevocational education sets arranged around a cluster of seven vocational offerings: agriculture, home…

  5. T & I--Building Construction, Safety. Kit No. 1. Instructor's Manual [and] Student Learning Activity Guide.

    ERIC Educational Resources Information Center

    Howard, John

    An instructor's manual and student activity guide on building construction safety are provided in this set of prevocational education materials which focuses on the vocational area of trade and industry. (This set of materials is one of ninety-two prevocational education sets arranged around a cluster of seven vocational offerings: agriculture,…

  6. Developing Critical Thinking Skills through the Use of Guided Laboratory Activities

    ERIC Educational Resources Information Center

    Croner, Patrick

    2003-01-01

    In a study to evaluate an approach for improving the critical thinking skills of middle school science students, 60 students were given the assignment of completing three guided laboratory activities and writing a report for each. In writing their reports, students were expected to identify the manipulated variable, identify the responding…

  7. Assisting in Radiology/Imaging. Instructor's Guide, Student's Manual, and Student Learning Activities.

    ERIC Educational Resources Information Center

    Fair, Helena J.

    The instructor's guide, the first of three documents in this package, is designed for a course to help students who are investigating the activities within a radiology department or considering any of the imaging technologies as a career. The material is designed to relate training experience to information studied in the classroom. This…

  8. Distributive Education--Shadow Box Display. Kit No. 72. Instructor's Manual [and] Student Learning Activity Guide.

    ERIC Educational Resources Information Center

    Rankin, Louise

    An instructor's manual and student activity guide on shadow box display are provided in this set of prevocational education materials which focuses on the vocational area of distributive education. (This set of materials is one of ninety-two prevocational education sets arranged around a cluster of seven vocational offerings: agriculture, home…

  9. Health Occupations--Thermometer. Kit No. 2. Instructor's Manual [and] Student Learning Activity Guide.

    ERIC Educational Resources Information Center

    Jackson, Janette

    An instructor's manual and student activity guide on the oral thermometer are provided in this set of prevocational education materials which focuses on the vocational area of health occupations. (This set of materials is one of ninety-two prevocational education sets arranged around a cluster of seven vocational offerings: agriculture, home…

  10. A Networking Guide on Teenage Pregnancy & Parenting in Maryland. Local Activities and Contact People.

    ERIC Educational Resources Information Center

    Interdepartmental Committee on Teenage Pregnancy and Parenting in Maryland, Baltimore.

    This networking guide is intended to encourage public agencies and the private sector throughout Maryland to share information, concerns, and strategies with one another regarding teenage pregnancy and parenting. The first section, a summary of local-level activities regarding teenage pregnancy and parenting, emphasizes efforts undertaken in…

  11. Minds-On Audio-Guided Activities (MAGA): More than Hearing and Better than Seeing

    ERIC Educational Resources Information Center

    Hancock, James Brian, II; Fornari, Marco

    2012-01-01

    Minds-On Audio-Guided Activities (MAGA) are podcast-delivered instruction designed to facilitate learning through all-body experiments. Instruction by MAGA has undergone preliminary testing in an introductory physics course at Central Michigan University. Topics are currently focused on mechanics and range from discovering the differences between…

  12. Medical Asepsis. Kit No. 302. Instructor's Manual [and] Student Learning Activity Guide. Health Occupations.

    ERIC Educational Resources Information Center

    Edwards, Gloria

    This instructor's manual and student learning guide comprise a module on medical asepsis for a secondary-level health occupations program. The six activities in the module cover medical asepsis terms; ways organisms spread; types of medical asepsis; aseptic equipment care; proper handwashing; and procedures for using masks, gloves, and gowns.…

  13. Suited for Spacewalking: A Teacher's Guide with Activities for Technology Education, Mathematics, and Science

    NASA Technical Reports Server (NTRS)

    Vogt, Gregory L.; George, Jane A. (Editor)

    1998-01-01

    A Teacher's Guide with Activities for Technology Education, Mathematics, and Science National Aeronautics and Space Administration Office of Human Resources and Education Education Division Washington, DC Education Working Group NASA Johnson Space Center Houston, Texas This publication is in the Public Domain and is not protected by copyright. Permission is not required for duplication.

  14. Agriculture--Forestry. Kit No. 31. Instructor's Manual [and] Student Learning Activity Guide.

    ERIC Educational Resources Information Center

    Sloan, Lee

    An instructor's manual and student activity guide on forestry are provided in this set of prevocational education materials which focuses on the vocational area of agriculture. (This set of materials is one of ninety-two prevocational education sets arranged around a cluster of seven vocational offerings: agriculture, home economics, distributive…

  15. Agriculture--Forestry Seedlings. Kit No. 53. Instructor's Manual [and] Student Learning Activity Guide.

    ERIC Educational Resources Information Center

    Walker, Larkin V., Jr.

    An instructor's manual and student activity guide on forestry seedlings are provided in this set of prevocational education materials which focuses on the vocational area of agriculture. (This set of materials is one of ninety-two prevocational education sets arranged around a cluster of seven vocational offerings: agriculture, home economics,…

  16. Distributive Education--Fashion Show. Kit No. 88. Instructor's Manual [and] Student Learning Activity Guide.

    ERIC Educational Resources Information Center

    Walters, Brenda B.

    An instructor's manual and student activity guide on fashion shows are provided in this set of prevocational education materials which focuses on the vocational area of distributive education. (This set of materials is one of ninety-two prevocational education sets arranged around a cluster of seven vocational offerings: agriculture, home…

  17. T & I--Metalworking, Forging. Kit No. 55. Instructor's Manual [and] Student Learning Activity Guide.

    ERIC Educational Resources Information Center

    Lake, Robert J.

    An instructor's manual and student activity guide on forging are provided in this set of prevocational education materials which focuses on the vocational area of trade and industry (metalworking). (This set of materials is one of ninety-two prevocational education sets arranged around a cluster of seven vocational offerings: agriculture, home…

  18. D.E.--Fashion Merchandising. Kit No. 43. Instructor's Manual [and] Student Learning Activity Guide.

    ERIC Educational Resources Information Center

    Walters, Brenda B.

    An instructor's manual and student activity guide on fashion merchandising are provided in this set of prevocational education materials which focuses on the vocational area of distributive education. (This set of materials is one of ninety-two prevocational education sets arranged around a cluster of seven vocational offerings: agriculture, home…

  19. Human Development Program: Pre-School and Kindergarten Activity Guide, Revised 1972.

    ERIC Educational Resources Information Center

    Bessell, Harold; Ball, Geraldine

    The curriculum guide presents the activities component of the Human Development Program for preschool and kindergarten students. The Human Development Program (HDP) is an affective curricular approach developed by psychologists. Major objectives of this program are to help children assume responsibility and build self-confidence. After a brief…

  20. Folklife and the Federal Government. A Guide to Activities, Resources, Funds, and Services.

    ERIC Educational Resources Information Center

    Coe, Linda C., Comp.

    The guide describes fifty-four diverse federal programs and activities which are potential sources of financial and other assistance to those interested in various aspects of folklife. Potential users are folk artists; folklorists; researchers in linguistics, anthropology, and ethnology; members of ethnic or regional groups involved in presenting…

  1. Office Occupations--Accounting, Payroll. Kit No. 64. Instructor's Manual [and] Student Learning Activity Guide.

    ERIC Educational Resources Information Center

    Conner, Connie

    An instructor's manual and student activity guide on payroll management are provided in this set of prevocational education materials which focuses on the vocational area of office occupations (accounting). (This set of materials is one of ninety-two prevocational education sets arranged around a cluster of seven vocational offerings: agriculture,…

  2. Self-Regulating Activity: Use of Metacognitive Guides in the Interpreting Classroom

    ERIC Educational Resources Information Center

    Canada, Maria Dolors; Arumi, Marta

    2012-01-01

    This research studies the development of metacognitive skills in students of consecutive interpreting from German into Spanish. The purpose is to discover which self-regulating processes appear after introducing a specific pedagogical action based on metacognitive guides. Our hypothesis is that self-regulating activity will increase as work with…

  3. Let's Meet Famous Artists. A Creative Art Activity Book. A Teacher's Guide Featuring 19 Famous Artists and Art Activities.

    ERIC Educational Resources Information Center

    Kinghorn, Harriet; And Others

    By studying the lives, important achievements, and works of famous artists, students may come to understand what those artists hoped to communicate to the world. By participating in art activities that are related to these artists' styles, students practice skills of observing, analyzing, and creating. This instructional guide provides…

  4. Classic to Contemporary: Famous Artists and Activities. A Teacher's Guide Featuring 19 Famous Artists' Biographies and Enrichment/Research Activities.

    ERIC Educational Resources Information Center

    Kinghorn, Harriet; Lewis-Spicer, Lisa

    By studying the lives, important achievements, and works of famous artists, students may come to understand what those artists hoped to communicate to the world. By participating in art activities that are related to these artists' styles, students practice skills of observing, analyzing, and creating. This instructional guide provides…

  5. Using activity-based costing and theory of constraints to guide continuous improvement in managed care.

    PubMed

    Roybal, H; Baxendale, S J; Gupta, M

    1999-01-01

    Activity-based costing and the theory of constraints have been applied successfully in many manufacturing organizations. Recently, those concepts have been applied in service organizations. This article describes the application of activity-based costing and the theory of constraints in a managed care mental health and substance abuse organization. One of the unique aspects of this particular application was the integration of activity-based costing and the theory of constraints to guide process improvement efforts. This article describes the activity-based costing model and the application of the theory of constraint's focusing steps with an emphasis on unused capacities of activities in the organization. PMID:10350791

  6. Using activity-based costing to guide strategic decision making.

    PubMed

    Dowless, R M

    1997-06-01

    Activity-based costing (ABC) is not widely used in the healthcare industry. Some healthcare provider organizations are considering ABC, however, because of its potential to improve resource management and thereby maximize efficiency. ABC supports better pricing practices through more accurate costing and can be used to identify underutilized resources as well as associated costs that can be reduced. ABC can be a useful tool for determining the cost of unused capacity and for making strategic management decisions that will reduce costs. PMID:10167847

  7. Suited for spacewalking: Teacher's guide with activities for physical and life science

    NASA Technical Reports Server (NTRS)

    Vogt, Gregory L.; Manning, Cheryl A.; Rosenberg, Carla B.

    1994-01-01

    Space walking has captured the imagination of generations of children and adults since science-fiction authors first placed their characters on the Moon. This publication is an activity guide for teachers interested in using the intense interest many children have in space exploration as a launching point for exciting hands-on learning opportunities. The guide begins with brief discussions of the space environment, the history of space walking, the Space Shuttle spacesuit, and working in space. These are followed by a series of activities that enable children to explore the space environment as well as the science and technology behind the functions of spacesuits. The activities are not rated for specific grade levels because they can be adapted for students of many ages. The chart on curriculum application at the back of the book is designed to help teachers incorporate activities into various subject areas.

  8. Guiding Catalytically Active Particles with Chemically Patterned Surfaces

    NASA Astrophysics Data System (ADS)

    Uspal, W. E.; Popescu, M. N.; Dietrich, S.; Tasinkevych, M.

    2016-07-01

    Catalytically active Janus particles suspended in solution create gradients in the chemical composition of the solution along their surfaces, as well as along any nearby container walls. The former leads to self-phoresis, while the latter gives rise to chemiosmosis, providing an additional contribution to self-motility. Chemiosmosis strongly depends on the molecular interactions between the diffusing chemical species and the wall. We show analytically, using an approximate "point-particle" approach, that by chemically patterning a planar substrate one can direct the motion of Janus particles: the induced chemiosmotic flows can cause particles to either "dock" at the chemical step between the two materials or follow a chemical stripe. These theoretical predictions are confirmed by full numerical calculations. Generically, docking occurs for particles which tend to move away from their catalytic caps, while stripe following occurs in the opposite case. Our analysis reveals the physical mechanisms governing this behavior.

  9. Gravity Probe B: Examining Einstein's Spacetime with Gyroscopes. An Educator's Guide with Activities in Space Science.

    ERIC Educational Resources Information Center

    Range, Shannon K'doah; Mullins, Jennifer

    This teaching guide introduces a relativity gyroscope experiment aiming to test two unverified predictions of Albert Einstein's general theory of relativity. An introduction to the theory includes the following sections: (1) "Spacetime, Curved Spacetime, and Frame-Dragging"; (2) "'Seeing' Spacetime with Gyroscopes"; (3) "The Gravity Probe B…

  10. Hospitality Services. Curriculum Guide [and] Student Activity Book [and] Reference Book.

    ERIC Educational Resources Information Center

    Texas Tech Univ., Lubbock. Curriculum Center for Family and Consumer Sciences.

    These three publications comprise a course that provides occupationally specific training designed to develop knowledge and skills for employment in the multifaceted hospitality services industry. The curriculum guide is the teacher component of the series. Contents include the Texas Essential Knowledge and Skills (TEKS); sample course outlines;…

  11. Looking at Earth from Space: Teacher's Guide with Activities for Earth and Space Science.

    ERIC Educational Resources Information Center

    National Aeronautics and Space Administration, Washington, DC.

    The Maryland Pilot Earth Science and Technology Education Network (MAPS-NET) project was sponsored by the National Aeronautics and Space Administration (NASA) to enrich teacher preparation and classroom learning in the area of Earth system science. This publication includes a teacher's guide that replicates material taught during a graduate-level…

  12. Activity Supplement for Puedo Leer: Teacher's Guide and Use of Charts. Program for Initial Reading in Spanish for Bilingual Children.

    ERIC Educational Resources Information Center

    Lopez, Sara

    This activity supplement is intended to accompany the Puedo Leer/I Can Read Teacher's Guide for initial reading in Spanish for bilingual children. The supplement, which consists of a teacher's guide and a set of charts on card stock, provides suggestions for a wide variety of pre-reading activities and approaches, which expand on the activities…

  13. Guiding catalytically active particles with chemically patterned surfaces

    NASA Astrophysics Data System (ADS)

    Uspal, William; Popescu, Mihail; Dietrich, Siegfried; Tasinkevych, Mykola

    Catalytically active Janus particles in solution create gradients in the chemical composition of the solution along their surfaces, as well as along any nearby container walls. The former leads to self-phoresis, while the latter gives rise to chemi-osmosis, providing an additional contribution to self-motility. Chemi-osmosis strongly depends on the molecular interactions between the diffusing chemical species and the wall. We show analytically, using an approximate ``point-particle'' approach, that by chemically patterning a planar substrate (e.g., by adsorbing two different materials) one can direct the motion of Janus particles: the induced chemi-osmotic flows can cause particles to either ``dock'' at a chemical step between the two materials, or to follow a chemical stripe. These theoretical predictions are confirmed by full numerical calculations. Generically, docking occurs for particles which tend to move away from their catalytic caps, while stripe-following occurs in the opposite case. Our analysis reveals the physical mechanisms governing this behavior.

  14. Using Assistive Technology Adaptations To Include Students with Learning Disabilities in Cooperative Learning Activities.

    ERIC Educational Resources Information Center

    Bryant, Diane Pedrotty; Bryant, Brian R.

    1998-01-01

    Discusses a process for integrating technology adaptations for students with learning disabilities into cooperative-learning activities in terms of three components: (1) selecting adaptations; (2) monitoring use of adaptations during cooperative-learning activities; and (3) evaluating the adaptations' effectiveness. Barriers to and support systems…

  15. Interest Inventory. [Includes Academic Interest Measure, Pupil Activity Inventory, and Semantic Differential].

    ERIC Educational Resources Information Center

    Harvard Univ., Cambridge, MA. Harvard Project Physics.

    This Interest Inventory contains three inventories: Academic Interest Measure (AIM), Pupil Activity Inventory (PAI), and Semantic Differential test (SD). The AIM measures six subscales of academic interests; the PAI measures non-school activities in science; and the SD measures attitudes toward science and physics. The inventories are designed for…

  16. Microgravity: A Teacher's Guide With Activities in Science, Mathematics, and Technology

    NASA Technical Reports Server (NTRS)

    Rogers, Melissa J. B.; Vogt, Gregory L.; Wargo, Michael J.

    1997-01-01

    The purpose of this curriculum supplement guide is to define and explain microgravity and show how microgravity can help us learn about the phenomena of our world. The front section of the guide is designed to provide teachers of science, mathematics, and technology at many levels with a foundation in microgravity science and applications. It begins with background information for the teacher on what microgravity is and how it is created. This is followed with information on the domains of microgravity science research; biotechnology, combustion science, fluid physics, fundamental physics, materials science, and microgravity research geared toward exploration. The background section concludes with a history of microgravity research and the expectations microgravity scientists have for research on the International Space Station. Finally, the guide concludes with a suggested reading list, NASA educational resources including electronic resources, and an evaluation questionnaire.

  17. Guide for Operational Configuration Management Program including the adjunct programs of design reconstitution and material condition and aging management. Part 1

    SciTech Connect

    Not Available

    1993-11-01

    This standard presents program criteria and implementation guidance for an operational configuration management program for DOE nuclear and non-nuclear facilities in the operational phase. Portions of this standard are also useful for other DOE processes, activities, and programs. This Part 1 contains foreword, glossary, acronyms, bibliography, and Chapter 1 on operational configuration management program principles. Appendices are included on configuration management program interfaces, and background material and concepts for operational configuration management.

  18. Activity-guided isolation of antioxidants from the leaves of Terminalia arjuna.

    PubMed

    Singh, Pradeep Pratap; Chauhan, S M S

    2014-01-01

    An activity-guided isolation and purification process was used to identify the l,l-diphenyl-2-picrylhydrazyl (DPPH) free radical-scavenging components of the food plant (Terminalia arjuna) of Antheraea mylitta. Dry leaves of T. arjuna were extracted with different solvents and tested for their antioxidant activity against DPPH(•). The acetone-water (8:2) extract expressed strong DPPH radical-scavenging activity, and was subjected to column chromatography over silica gel. Gallic acid, apigenin, luteolin, quercetin, epicatechin, ellagic acid and 1-O-β-galloyl glucose were isolated as active components and characterised by using different spectroscopic techniques. PMID:24484080

  19. MiDAS: the field guide to the microbes of activated sludge

    PubMed Central

    McIlroy, Simon Jon; Saunders, Aaron Marc; Albertsen, Mads; Nierychlo, Marta; McIlroy, Bianca; Hansen, Aviaja Anna; Karst, Søren Michael; Nielsen, Jeppe Lund; Nielsen, Per Halkjær

    2015-01-01

    The Microbial Database for Activated Sludge (MiDAS) field guide is a freely available online resource linking the identity of abundant and process critical microorganisms in activated sludge wastewater treatment systems to available data related to their functional importance. Phenotypic properties of some of these genera are described, but most are known only from sequence data. The MiDAS taxonomy is a manual curation of the SILVA taxonomy that proposes a name for all genus-level taxa observed to be abundant by large-scale 16 S rRNA gene amplicon sequencing of full-scale activated sludge communities. The taxonomy can be used to classify unknown sequences, and the online MiDAS field guide links the identity to the available information about their morphology, diversity, physiology and distribution. The use of a common taxonomy across the field will provide a solid foundation for the study of microbial ecology of the activated sludge process and related treatment processes. The online MiDAS field guide is a collaborative workspace intended to facilitate a better understanding of the ecology of activated sludge and related treatment processes—knowledge that will be an invaluable resource for the optimal design and operation of these systems. Database URL: http://www.midasfieldguide.org PMID:26120139

  20. MiDAS: the field guide to the microbes of activated sludge.

    PubMed

    McIlroy, Simon Jon; Saunders, Aaron Marc; Albertsen, Mads; Nierychlo, Marta; McIlroy, Bianca; Hansen, Aviaja Anna; Karst, Søren Michael; Nielsen, Jeppe Lund; Nielsen, Per Halkjær

    2015-01-01

    The Microbial Database for Activated Sludge (MiDAS) field guide is a freely available online resource linking the identity of abundant and process critical microorganisms in activated sludge wastewater treatment systems to available data related to their functional importance. Phenotypic properties of some of these genera are described, but most are known only from sequence data. The MiDAS taxonomy is a manual curation of the SILVA taxonomy that proposes a name for all genus-level taxa observed to be abundant by large-scale 16 S rRNA gene amplicon sequencing of full-scale activated sludge communities. The taxonomy can be used to classify unknown sequences, and the online MiDAS field guide links the identity to the available information about their morphology, diversity, physiology and distribution. The use of a common taxonomy across the field will provide a solid foundation for the study of microbial ecology of the activated sludge process and related treatment processes. The online MiDAS field guide is a collaborative workspace intended to facilitate a better understanding of the ecology of activated sludge and related treatment processes--knowledge that will be an invaluable resource for the optimal design and operation of these systems. PMID:26120139

  1. Intracellular activity of clinical concentrations of phenothiazines including thioridiazine against phagocytosed Staphylococcus aureus.

    PubMed

    Ordway, Diane; Viveiros, Miguel; Leandro, Clara; Arroz, Maria Jorge; Amaral, Leonard

    2002-07-01

    The effect of thioridazine (TZ) was studied on the killing activity of human peripheral blood monocyte derived macrophages (HPBMDM) and of human macrophage cell line THP-1 at extracellular concentrations below those achievable clinically. These macrophages have nominal killing activity against bacteria and therefore, would not influence any activity that the compounds may have against intracellular localised Staphylococcus aureus. The results indicated that whereas TZ has an in vitro minimum inhibitory concentration (MIC) against the strains of S. aureus of 18, 0.1 mg/l of TZ in the medium completely inhibits the growth of S. aureus that has been phagocytosed by macrophages. The latter concentration was non-toxic to macrophages, did not cause cellular expression of activation marker CD69 nor induction of CD3+ T cell production of IFN-gamma, but blocked cellular proliferation and down-regulated the production of T cell-derived cytokines (IFN-gamma, IL-5). These results suggest that TZ induces intracellular bactericidal activities independent of the capacity to generate Type 1 responses against S. aureus. PMID:12127709

  2. Diffractive laser beam homogenizer including a photo-active material and method of fabricating the same

    DOEpatents

    Bayramian, Andy J; Ebbers, Christopher A; Chen, Diana C

    2014-05-20

    A method of manufacturing a plurality of diffractive optical elements includes providing a partially transmissive slide, providing a first piece of PTR glass, and directing first UV radiation through the partially transmissive slide to impinge on the first piece of PTR glass. The method also includes exposing predetermined portions of the first piece of PTR glass to the first UV radiation and thermally treating the exposed first piece of PTR glass. The method further includes providing a second piece of PTR glass and directing second UV radiation through the thermally treated first piece of PTR glass to impinge on the second piece of PTR glass. The method additionally includes exposing predetermined portions of the second piece of PTR glass to the second UV radiation, thermally treating the exposed second piece of PTR glass, and repeating providing and processing of the second piece of PTR glass using additional pieces of PTR glass.

  3. Electrode including porous particles with embedded active material for use in a secondary electrochemical cell

    DOEpatents

    Vissers, Donald R.; Nelson, Paul A.; Kaun, Thomas D.; Tomczuk, Zygmunt

    1978-04-25

    Particles of carbonaceous matrices containing embedded electrode active material are prepared for vibratory loading within a porous electrically conductive substrate. In preparing the particles, active materials such as metal chalcogenides, solid alloys of alkali or alkaline earth metals along with other metals and their oxides in powdered or particulate form are blended with a thermosetting resin and particles of a volatile to form a paste mixture. The paste is heated to a temperature at which the volatile transforms into vapor to impart porosity at about the same time as the resin begins to cure into a rigid, solid structure. The solid structure is then comminuted into porous, carbonaceous particles with the embedded active material.

  4. Sixty Minutes of Physical Activity per Day Included within Preschool Academic Lessons Improves Early Literacy

    ERIC Educational Resources Information Center

    Kirk, Stacie M.; Kirk, Erik P.

    2016-01-01

    Background: The effects of increases in physical activity (PA) on early literacy skills in preschool children are not known. Methods: Fifty-four African-American preschool children from a low socioeconomic urban Head Start participated over 8 months. A 2-group, quasi-experimental design was used with one preschool site participating in the PA…

  5. 7 CFR 981.441 - Credit for market promotion activities, including paid advertising.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... AGRICULTURE ALMONDS GROWN IN CALIFORNIA Administrative Rules and Regulations § 981.441 Credit for market... each activity shall be to promote the sale, consumption or use of California almonds, and nothing... in California almond growing counties with more than 1,000 bearing acres: Provided, That...

  6. Observing a fictitious stressful event: haematological changes, including circulating leukocyte activation.

    PubMed

    Mian, Rubina; Shelton-Rayner, Graham; Harkin, Brendan; Williams, Paul

    2003-03-01

    The aim of this study was to assess the effect of watching a psychological stressful event on the activation of leukocytes in healthy human volunteers. Blood samples were obtained from 32 healthy male and female subjects aged between 20 and 26 years before, during and after either watching an 83-minute horror film that none of the subjects had previously seen (The Texas Chainsaw Massacre, 1974) or by sitting quietly in a room (control group). Total differential cell counts, leukocyte activation as measured by the nitroblue tetrazolium (NBT) test, heart rate and blood pressure (BP) measurements were taken at defined time points. There were significant increases in peripheral circulating leukocytes, the number of activated circulating leukocytes, haemoglobin (Hb) concentration and haematocrit (Hct) in response to the stressor. These were accompanied by significant increases in heart rate, systolic and diastolic BP (P<0.05 from baseline). This is the first reported study on the effects of observing a psychologically stressful, albeit fictitious event on circulating leukocyte numbers and the state of leukocyte activation as determined by the nitrotetrazolium test. PMID:12637206

  7. Beyond Right or Wrong: Challenges of Including Creative Design Activities in the Classroom

    ERIC Educational Resources Information Center

    Brennan, Karen

    2015-01-01

    In this article, we explore challenges encountered by K-12 educators in establishing classroom cultures that support creative learning activities with the Scratch programming language. Providing opportunities for students to understand and to build capacities for creative work was described by many of the teachers that we interviewed as a central…

  8. Physical Activity Programs in Higher Education: Modifying Net/Wall Games to Include Individuals with Disabilities

    ERIC Educational Resources Information Center

    Braga, Luciana; Tracy, Julia F.; Taliaferro, Andrea R.

    2015-01-01

    The growing number of students with disabilities in higher education settings has presented challenges for instructors with regards to appropriate inclusion. Concerning physical activity courses in higher education, instructors may not have the knowledge or resources to make modifications and accommodations that will ultimately result in…

  9. Population and Human Development: A Course Curriculum Including Lesson Plans, Activities and Bibliography.

    ERIC Educational Resources Information Center

    Murphy, Elaine M.

    This course outline suggests materials and learning activities on the interrelated causes and consequences of population growth and other population concerns. Designed to educate general college audiences, it is also intended for use as a preservice course for teachers. In addition, the course can be modified for high school students. The course…

  10. A novel peptide inhibitor of classical and lectin complement activation including ABO incompatibility

    PubMed Central

    Mauriello, Clifford T.; Pallera, Haree K.; Sharp, Julia A.; Woltmann, Jon L.; Qian, Shizhi; Hair, Pamela S.; van der Pol, Pieter; van Kooten, Cees; Thielens, Nicole M.; Lattanzio, Frank A.; Cunnion, Kenji M.; Krishna, Neel K.

    2012-01-01

    Previous experiments from our laboratories have identified peptides derived from the human astrovirus coat protein (CP) that bind C1q and mannose binding lectin (MBL) inhibiting activation of the classical and lectin pathways of complement, respectively. The purpose of this study was to evaluate the function of these coat protein peptides (CPPs) in an in vitro model of complement-mediated disease (ABO incompatibility), preliminarily assess their in vivo complement suppression profile and develop more highly potent derivatives of these molecules. E23A, a 30 amino acid CPP derivative previously demonstrated to inhibit classical pathway activation was able to dose-dependently inhibit lysis of AB erythrocytes treated with mismatched human O serum. Additionally, when injected into rats, E23A inhibited the animals’ serum from lysing antibody-sensitized erythrocytes, providing preliminary in vivo functional evidence that this CPP can cross the species barrier to inhibit serum complement activity in rodents. A rational drug design approach was implemented to identify more potent CPP derivatives, resulting in the identification and characterization of a 15 residue peptide (Polar Assortant (PA)), which demonstrated both superior inhibition of classical complement pathway activation and robust binding to C1q collagen-like tails. PA also inhibited ABO incompatibility in vitro and demonstrated in vivo complement suppression up to 24 hours post-injection. CPP’s ability to inhibit ABO incompatibility in vitro, proof of concept in vivo inhibitory activity in rats and the development of the highly potent PA derivative set the stage for preclinical testing of this molecule in small animal models of complement-mediated disease. PMID:22906481

  11. An Updated Review of Interventions that Include Promotion of Physical Activity for Adult Men.

    PubMed

    Bottorff, Joan L; Seaton, Cherisse L; Johnson, Steve T; Caperchione, Cristina M; Oliffe, John L; More, Kimberly; Jaffer-Hirji, Haleema; Tillotson, Sherri M

    2015-06-01

    The marked disparity in life expectancy between men and women suggests men are a vulnerable group requiring targeted health promotion programs. As such, there is an increasing need for health promotion strategies that effectively engage men with their health and/or illness management. Programs that promote physical activity could significantly improve the health of men. Although George et al. (Sports Med 42(3):281, 30) reviewed physical activity programs involving adult males published between 1990 and 2010, developments in men's health have prompted the emergence of new sex- and gender-specific approaches targeting men. The purpose of this review was to: (1) extend and update the review undertaken by George et al. (Sports Med 42(3):281, 30) concerning the effectiveness of physical activity programs in males, and (2) evaluate the integration of gender-specific influences in the content, design, and delivery of men's health promotion programs. A search of MEDLINE, CINAHL, ScienceDirect, Web of Science, PsycINFO, the Cochrane Library, and the SPORTDiscus databases for articles published between January 2010 and August 2014 was conducted. In total, 35 studies, involving evaluations of 31 programs, were identified. Findings revealed that a variety of techniques and modes of delivery could effectively promote physical activity among men. Though the majority of programs were offered exclusively to men, 12 programs explicitly integrated gender-related influences in male-specific programs in ways that recognized men's interests and preferences. Innovations in male-only programs that focus on masculine ideals and gender influences to engage men in increasing their physical activity hold potential for informing strategies to promote other areas of men's health. PMID:25430599

  12. Guidelines for Communicable Disease Control Policies in Montana Schools: A Guide and Model Policy for Communicable Diseases Including HIV Infected Students and Staff.

    ERIC Educational Resources Information Center

    Montana State Dept. of Public Instruction, Helena.

    This guide was developed to help local school districts review existing policies or establish new policies to address communicable diseases. Based on current scientific and medical information about the safety in allowing human immunodeficiency virus (HIV) infected students and staff to remain at school, it contains a suggested policy for local…

  13. Improving Indonesia's Cities: A Case Study of Economic Development, Including a Teaching Guide and An Economic Summary of Indonesia. Toward a Better World Series, Learning Kit No. 5.

    ERIC Educational Resources Information Center

    Baldwin, Harriet, Ed.; Rosen, Carol, Ed.

    This World Bank (Washington, D.C.) kit is designed to teach secondary school social studies students the impact of rapid urbanization on Jakarta, the capital city of Indonesia. The kit contains a pamphlet, a booklet, a filmstrip, and a teacher's guide. The pamphlet, "An Economic Summary of Indonesia" provides students with the structure, recent…

  14. The stepwise multi-photon activation fluorescence guided ablation of melanin

    NASA Astrophysics Data System (ADS)

    Lai, Zhenhua; Gu, Zetong; DiMarzio, Charles

    2015-02-01

    Previous research has shown that the stepwise multi-photon activation fluorescence (SMPAF) of melanin, activated and excited by a continuous-wave (CW) mode near infrared (NIR) laser, is a low-cost and reliable method for detecting melanin. We have developed a device utilizing the melanin SMPAF to guide the ablation of melanin with a 975 nm CW laser. This method provides the ability of targeting individual melanin particles with micrometer resolution, and enables localized melanin ablation to be performed without collateral damage. Compared to the traditional selective photothermolysis, which uses pulsed lasers for melanin ablation, this method demonstrates higher precision and lower cost. Therefore, the SMPAF guided selective ablation of melanin is a promising tool of melanin ablation for both medical and cosmetic purposes.

  15. Space Resources for Teachers: Biology, Including Suggestions for Classroom Activities and Laboratory Experiments.

    ERIC Educational Resources Information Center

    Lee, Tom E.; And Others

    This compilation of resource units concerns the latest developments in space biology. Some of the topics included are oxygen consumption, temperature, radiation, rhythms, weightlessness, acceleration and vibration stress, toxicity, and sensory and perceptual problems. Many of the topics are interdisciplinary and relate biology, physiology,…

  16. Seeing in a new light: Astro-1 teacher's guide with activities

    NASA Technical Reports Server (NTRS)

    1990-01-01

    A teacher's guide that concentrates on the electromagnetic spectrum is presented. The subject was chosen because it is part of the middle school curriculum and because an understanding of the different ranges of energy is crucial to an understanding of the high energy astronomy performed by the Astro-1 telescopes to be carried on the Space Shuttle's first astrophysics mission. Various learning activities are outlined.

  17. Activity of faropenem tested against Neisseria gonorrhoeae isolates including fluoroquinolone-resistant strains.

    PubMed

    Jones, Ronald N; Critchley, Ian A; Whittington, William L H; Janjic, Nebojsa; Pottumarthy, Sudha

    2005-12-01

    We evaluated the anti-gonococcal potency of faropenem along with 7 comparator reference antimicrobials against a preselected collection of clinical isolates. The 265 isolates were inclusive of 2 subsets: 1) 76 well-characterized resistant phenotypes of gonococcal strains (53 quinolone-resistant strains--31 with documented quinolone resistance-determining region changes from Japan, 15 strains resistant to penicillin and tetracycline, and 8 strains with intermediate susceptibility to penicillin) and 2) 189 recent isolates from clinical specimens in 2004 from 6 states across the United States where quinolone resistance is prevalent. Activity of faropenem was adversely affected by l-cysteine hydrochloride in IsoVitaleX (4-fold increase in [minimal inhibitory concentration] MIC50; 0.06 versus 0.25 microg/mL). The rank order of potency of the antimicrobials for the entire collection was ceftriaxone (MIC90, 0.06 microg/mL) > faropenem (0.25 microg/mL) > azithromycin (0.5 microg/mL) > cefuroxime (1 microg/mL) > tetracycline (2 microg/mL) > penicillin = ciprofloxacin = levofloxacin (4 microg/mL). Using MIC90 for comparison, faropenem was 4-fold more potent than cefuroxime (0.25 versus 1 microg/mL), but was 4-fold less active than ceftriaxone (0.25 versus 0.06 microg/mL). Although the activity of faropenem was not affected by either penicillinase production (MIC90, 0.12 microg/mL, penicillinase-positive) or increasing ciprofloxacin MIC (0.25 microg/mL, ciprofloxacin-resistant), increasing penicillin MIC was associated with an increase in MIC90 values (0.016 microg/mL for penicillin-susceptible to 0.25 microg/mL for penicillin-resistant strains). Among the recent (2004) clinical gonococcal isolates tested, reduced susceptibility to penicillins, tetracycline, and fluoroquinolones was high (28.0-94.2%). Geographic distribution of the endemic resistance rates of gonococci varied considerably, with 16.7-66.7% of the gonococcal isolates being ciprofloxacin-resistant in Oregon

  18. Phytophthora infestans Has a Plethora of Phospholipase D Enzymes Including a Subclass That Has Extracellular Activity

    PubMed Central

    Meijer, Harold J. G.; Hassen, Hussen Harrun; Govers, Francine

    2011-01-01

    In eukaryotes phospholipase D (PLD) is involved in many cellular processes. Currently little is known about PLDs in oomycetes. Here we report that the oomycete plant pathogen Phytophthora infestans has a large repertoire of PLDs divided over six subfamilies: PXPH-PLD, PXTM-PLD, TM-PLD, PLD-likes, and type A and B sPLD-likes. Since the latter have signal peptides we developed a method using metabolically labelled phospholipids to monitor if P. infestans secretes PLD. In extracellular medium of ten P. infestans strains PLD activity was detected as demonstrated by the production of phosphatidic acid and the PLD specific marker phosphatidylalcohol. PMID:21423760

  19. The Big Jump: A Classroom Guide for Teaching Insurance to Teenagers and Young Adults through Creative Activities.

    ERIC Educational Resources Information Center

    Credit Union National Association, Inc., Madison, WI.

    This kit contains a teaching guide with objectives, answers, and instructions for each activity and spirit masters color coded to correspond with the appropriate chapter in the teaching guide. Five program segments are presented: (1) introduction to insurance; (2) homeowners/renters insurance; (3) automobile and motorcycle insurance; (4) health…

  20. Evaluation of school-based dental health activities including fluoride mouth-rinsing in Hiraizumi, Japan.

    PubMed

    Ohara, S; Kawaguchi, Y; Shinada, K; Sasaki, Y

    2000-06-01

    School-based dental health activities conducted in Hiraizumi over the past 20 years have remarkably improved the dental health status of schoolchildren. For example, DMFT index of 12-year-old children decreased to 1.5 in 1998, one-half that of the national average. School dental health activities, which were focused on dental health education, resulted in an increase of filled teeth rates, a decrease in the number of missing teeth, and a decline in incisor caries (1979-1986). In addition, the introduction of a school-based fluoride mouth-rinsing program (1986 - ) showed a positive effect on the prevention of dental caries; a significant decrease was observed in the overall prevalence of dental caries, particularly in the molars. In Japan it seems advantageous to promote the dental health of schoolchildren by school-based programs that combine dental health examination, dental health education and fluoride mouth-rinsing program. Especially, to prevent dental caries in the mandibular first molars more effectively, it is recommended to start fluoride mouth-rinsing at age 5. PMID:12160185

  1. A Teacher's Guide to Resource - Use Outdoor Education Center.

    ERIC Educational Resources Information Center

    Taylor County Board of Public Instruction, Perry, FL.

    Included in this guide are ideas on evaluation and conduct of outdoor education classes and unit guides and lesson plans. An interdisciplinary approach is emphasized and the unit guides and lesson plans present activities related to science, mathematics, social studies, art, and music relevant to outdoor education in general. Unit guides for soil,…

  2. A Methodology for Post Operational Clean Out of a Highly Active Facility Including Solids Behaviour - 12386

    SciTech Connect

    Edmondson, Michael J.; Ward, Tracy R.; Maxwell, Lisa J.

    2012-07-01

    The Highly Active Liquor Evaporation and Storage (HALES) plant at Sellafield handles acidic fission product containing liquor with typical activities of the order of 18x10{sup 9} Bq/ml. A strategy experimental feedback approach has been used to establish a wash regime for the Post Operational Clean Out (POCO) of the oldest storage tanks for this liquor. Two different wash reagents have been identified as being potentially suitable for removal of acid insoluble fission product precipitates. Ammonium carbamate and sodium carbonate yield similar products during the proposed wash cycle. The proposed wash reagents provide dissolution of caesium phosphomolybdate (CPM) and zirconium molybdate (ZM) solid phases but yields a fine, mobile precipitate of metal carbonates from the Highly Active Liquor (HAL) supernate. Addition of nitric acid to the wash effluent can cause CPM to precipitate where there is sufficient caesium and phosphorous available. Where they are not present (from ZM dissolution) the nitric acid addition initially produces a nitrate precipitate which then re-dissolves, along with the metal carbonates, to give a solid-free solution. The different behaviour of the two solids during the wash cycle has led to the proposal for an amended flowsheet. Additional studies on the potential to change the morphology of crystallising ZM have presented opportunities for changing the rheology of ZM sediments through doping with tellurium or particular organic acids. Two different wash reagents have been identified as being potentially suitable for the POCO of HALES Oldside HASTs. AC and SC both yield similar products during the proposed wash cycle. However, the different behaviour of the two principle HAL solids, CPM and ZM, during the wash cycle has led to the proposal for an amended flowsheet. Additional studies on the potential to change the morphology of crystallising ZM have presented opportunities for changing its rheology through doping with tellurium or certain

  3. Microgravity: A Teacher's Guide with Activities in Science, Mathematics, and Technology

    NASA Technical Reports Server (NTRS)

    Rogers, Melissa J.B.; Vogt, Gregory L.; Wargo, Michael J.

    1997-01-01

    Microgravity is the subject of this teacher's guide. This publication identifies the underlying mathematics, physics, and technology principles that apply to microgravity. The topics included in this publication are: 1) Microgravity Science Primer; 2) The Microgravity Environment of Orbiting Spacecraft; 3) Biotechnology; 4) Combustion Science; 5) Fluid Physics; 6) Fundamental Physics; and 7) Materials Science; 8) Microgravity Research and Exploration; and 9) Microgravity Science Space Flights. This publication also contains a glossary of selected terms.

  4. Curriculum Guide for Fashion Merchandising (Fashion Salesperson).

    ERIC Educational Resources Information Center

    Gregory, Margaret R.

    This curriculum guide is designed to help teachers teach a course in fashion merchandising to high school students. The guide contains eight performance-based learning modules, each consisting of one to seven units. Each unit teaches a job-relevant task, and includes performance objectives, performance guides, resources, learning activities,…

  5. Steady-state analysis of activated sludge processes with a settler model including sludge compression.

    PubMed

    Diehl, S; Zambrano, J; Carlsson, B

    2016-01-01

    A reduced model of a completely stirred-tank bioreactor coupled to a settling tank with recycle is analyzed in its steady states. In the reactor, the concentrations of one dominant particulate biomass and one soluble substrate component are modelled. While the biomass decay rate is assumed to be constant, growth kinetics can depend on both substrate and biomass concentrations, and optionally model substrate inhibition. Compressive and hindered settling phenomena are included using the Bürger-Diehl settler model, which consists of a partial differential equation. Steady-state solutions of this partial differential equation are obtained from an ordinary differential equation, making steady-state analysis of the entire plant difficult. A key result showing that the ordinary differential equation can be replaced with an approximate algebraic equation simplifies model analysis. This algebraic equation takes the location of the sludge-blanket during normal operation into account, allowing for the limiting flux capacity caused by compressive settling to easily be included in the steady-state mass balance equations for the entire plant system. This novel approach grants the possibility of more realistic solutions than other previously published reduced models, comprised of yet simpler settler assumptions. The steady-state concentrations, solids residence time, and the wastage flow ratio are functions of the recycle ratio. Solutions are shown for various growth kinetics; with different values of biomass decay rate, influent volumetric flow, and substrate concentration. PMID:26476681

  6. Nuclear Rocket Test Facility Decommissioning Including Controlled Explosive Demolition of a Neutron-Activated Shield Wall

    SciTech Connect

    Michael Kruzic

    2007-09-01

    Located in Area 25 of the Nevada Test Site, the Test Cell A Facility was used in the 1960s for the testing of nuclear rocket engines, as part of the Nuclear Rocket Development Program. The facility was decontaminated and decommissioned (D&D) in 2005 using the Streamlined Approach For Environmental Restoration (SAFER) process, under the Federal Facilities Agreement and Consent Order (FFACO). Utilities and process piping were verified void of contents, hazardous materials were removed, concrete with removable contamination decontaminated, large sections mechanically demolished, and the remaining five-foot, five-inch thick radiologically-activated reinforced concrete shield wall demolished using open-air controlled explosive demolition (CED). CED of the shield wall was closely monitored and resulted in no radiological exposure or atmospheric release.

  7. Quasielastic neutron scattering experiments including activation energies and mathematical modeling of methyl halide dynamics

    NASA Astrophysics Data System (ADS)

    Kirstein, O.; Prager, M.; Grimm, H.; Buchsteiner, A.; Wischnewski, A.

    2007-09-01

    Quasielastic neutron scattering experiments were carried out using the multichopper time-of-flight spectrometer V3 at the Hahn-Meitner Institut, Germany and the backscattering spectrometer at Forschungszentrum Jülich, Germany. Activation energies for CH3X, X =F, Cl, Br, and I, were obtained. In combination with results from previous inelastic neutron scattering experiments the data were taken to describe the dynamics of the halides in terms of two different models, the single particle model and the coupling model. Coupled motions of methyl groups seem to explain the dynamics of the methyl fluoride and chloride; however, the coupling vanishes with the increase of the mass of the halide atom in CH3Br and CH3I.

  8. LIPID PEROXIDATION GENERATES BIOLOGICALLY ACTIVE PHOSPHOLIPIDS INCLUDING OXIDATIVELY N-MODIFIED PHOSPHOLIPIDS

    PubMed Central

    Davies, Sean S.; Guo, Lilu

    2014-01-01

    Peroxidation of membranes and lipoproteins converts “inert” phospholipids into a plethora of oxidatively modified phospholipids (oxPL) that can act as signaling molecules. In this review, we will discuss four major classes of oxPL: mildly oxygenated phospholipids, phospholipids with oxidatively truncated acyl chains, phospholipids with cyclized acyl chains, and phospholipids that have been oxidatively N-modified on their headgroups by reactive lipid species. For each class of oxPL we will review the chemical mechanisms of their formation, the evidence for their formation in biological samples, the biological activities and signaling pathways associated with them, and the catabolic pathways for their elimination. We will end by briefly highlighting some of the critical questions that remain about the role of oxPL in physiology and disease. PMID:24704586

  9. Patient Activated Care for Rural Elderly. A Program Development and Teaching Guide for Planners, Facilitators, and Coordinators.

    ERIC Educational Resources Information Center

    Gaarder, Lorin R.; Cohen, Saul

    This guide is an outline for developing and presenting programs in self health care for senior citizens. The guide is presented in two sections. The first section provides background information about elderly self-care and tips on teaching it and developing a program. Sample letters to prospective enrollees and sample news releases are included.…

  10. Fatty acid-releasing activities in Sinorhizobium meliloti include unusual diacylglycerol lipase.

    PubMed

    Sahonero-Canavesi, Diana X; Sohlenkamp, Christian; Sandoval-Calderón, Mario; Lamsa, Anne; Pogliano, Kit; López-Lara, Isabel M; Geiger, Otto

    2015-09-01

    Phospholipids are well known for their membrane-forming properties and thereby delimit any cell from the exterior world. In addition, membrane phospholipids can act as precursors for signals and other biomolecules during their turnover. Little is known about phospholipid signalling, turnover and remodelling in bacteria. Recently, we showed that a FadD-deficient mutant of Sinorhizobium meliloti, unable to convert free fatty acids to their coenzyme A derivatives, accumulates free fatty acids during the stationary phase of growth. Enzymatic activities responsible for the generation of these free fatty acids were unknown in rhizobia. Searching the genome of S. meliloti, we identified a potential lysophospholipase (SMc04041) and two predicted patatin-like phospholipases A (SMc00930, SMc01003). Although SMc00930 as well as SMc01003 contribute to the release of free fatty acids in S. meliloti, neither one can use phospholipids as substrates. Here we show that SMc01003 converts diacylglycerol to monoacylglycerol and a fatty acid, and that monoacylglycerol can be further degraded by SMc01003 to another fatty acid and glycerol. A SMc01003-deficient mutant of S. meliloti transiently accumulates diacylglycerol, suggesting that SMc01003 also acts as diacylglycerol lipase (DglA) in its native background. Expression of the DglA lipase in Escherichia coli causes lysis of cells in stationary phase of growth. PMID:25711932

  11. Ozone control of biological activity during Earth's history, including the KT catastrophe

    NASA Technical Reports Server (NTRS)

    Sheldon, W. R.

    1994-01-01

    There have been brief periods since the beginning of the Cambrian some 600 m.y. ago when mass extinctions destroyed a significant fraction of living species. The most widely studied of these events is the catastrophe at the KT boundary that ended the long dominance of the dinosaurs. In addition to mass extinctions, there is another profound discontinuity in the history of Earth's biota, the explosion of life at the end of the Precambrian era which is an episode that is not explained well at all. For some 3 b.y. before the Cambrian, life had been present on Earth, but maintained a low level of activity which is an aspect of the biota that is puzzling, especially during the last two-thirds of that period. During the last 2 b.y. before the Cambrian, conditions at the Earth's surface were suitable for a burgeoning of the biota, according to most criteria: the oceans neither boiled nor were fozen solid during this time, and the atmosphere contained sufficient O for the development of animals. The purpose of this paper is to suggest that mass extinctions and the lackluster behavior of the Precambrian biota share a common cause: an inadequate amount of ozone in the atmosphere.

  12. Design of a high-lift experiment in water including active flow control

    NASA Astrophysics Data System (ADS)

    Beutel, T.; Sattler, S.; El Sayed, Y.; Schwerter, M.; Zander, M.; Büttgenbach, S.; Leester-Schädel, M.; Radespiel, R.; Sinapius, M.; Wierach, P.

    2014-07-01

    This paper describes the structural design of an active flow-control experiment. The aim of the experiment is to investigate the increase in efficiency of an internally blown Coanda flap using unsteady blowing. The system uses tailor-made microelectromechanical (MEMS) pressure sensors to determine the state of the oncoming flow and an actuated lip to regulate the mass flow and velocity of a stream near a wall over the internally blown flap. Sensors and actuators are integrated into a highly loaded system that is extremely compact. The sensors are connected to a bus system that feeds the data into a real-time control system. The piezoelectric actuators using the d 33 effect at a comparable low voltage of 120 V are integrated into a lip that controls the blowout slot height. The system is designed for closed-loop control that efficiently avoids flow separation on the Coanda flap. The setup is designed for water-tunnel experiments in order to reduce the free-stream velocity and the system’s control frequency by a factor of 10 compared with that in air. This paper outlines the function and verification of the system’s main components and their development.

  13. Teaching reactions and stoichiometry: A comparison of guided inquiry and traditional laboratory activities

    NASA Astrophysics Data System (ADS)

    Meister Thomas, Lynn

    There is a major movement in science education towards the inclusion of science inquiry and process. Guided-inquiry instruction is expected to have a positive impact on students' concrete and conceptual knowledge along with their ability to engage in the practices of science. This study examined the impact of inquiry-based teaching on student achievement. The topics of reactions and stoichiometry were taught in two different periods of first-year secondary honors chemistry. Both classes received the same lectures and assignments for this curriculum and both classes performed the same laboratory activities. However, one class received traditional, step-by-step (often called "cookbook") laboratory instructions while the other class developed their own procedures and made decisions about data to complete the laboratory activities. Pre- and post-tests were given to each class, followed by a test of retention after ten weeks. The results of this study indicate that inquiry-based instruction has a positive impact on student achievement. A significant increase between pre- and post- test scores for the experimental group as opposed to the scores for the control group suggests that achievement was correlated with guided inquiry instruction methods. Additionally, a notable trend suggested that guided inquiry instruction has a positive effect on learning retention.

  14. Differences in Lifestyles Including Physical Activity According to Sexual Orientation among Korean Adolescents

    PubMed Central

    YOON, Jin-Ho; SO, Wi-Young

    2013-01-01

    Abstract Background The purpose of the present study was to examine differences in lifestyle factors such as physical activity among homosexual (gay or lesbian), bisexual, and heterosexual Korean adolescents. Methods The sample consisted of 74,186 adolescents from grades 7—12 (ages 12—18) who participated in the 8th annual Korea Youth Risk Behavior Web-based Survey in 2012. Of this sample, only 11,829 provided enough information regarding their romantic and sexual experiences to define them as gay, lesbian, bisexual, or heterosexual. From this information, males were divided into gay (n = 323), bisexual (n = 243), and heterosexual (n = 6,501) groups, and females were divided into lesbian (n = 208), bisexual (n = 113), and heterosexual (n = 4,441) groups. Differences in lifestyle factors according to sexual orientation were analyzed using one-way analysis of variance. Results Males showed significant differences by sexual orientation group in terms of frequency of smoking (P = 0.029), alcohol consumption (P < 0.001), muscular strength exercises (P = 0.020), and walking for at least 10 minutes per week (P < 0.001). Females showed significant differences by sexual orientation group in terms of frequency of smoking (P < 0.001), alcohol consumption (P < 0.001), vigorous physical exercise (P < 0.001), moderate physical exercise (P < 0.001), and muscular strength exercises (P < 0.001), as well as for self-reported mental stress (P < 0.001). Conclusion We concluded those gay and bisexual males and lesbian and bisexual females had significant lifestyle differences as compared with heterosexual adolescents. This effect was stronger for females than for males. PMID:26060636

  15. RADIO PROPERTIES OF LOW-REDSHIFT BROAD-LINE ACTIVE GALACTIC NUCLEI INCLUDING EXTENDED RADIO SOURCES

    SciTech Connect

    Rafter, Stephen E.; Crenshaw, D. Michael; Wiita, Paul J.

    2011-03-15

    We present a study of the extended radio emission in a sample of 8434 low-redshift (z < 0.35) broad-line active galactic nuclei (AGNs) from the Sloan Digital Sky Survey. To calculate the jet and lobe contributions to the total radio luminosity, we have taken the 846 radio core sources detected in our previous study of this sample and performed a systematic search in the FIRST database for extended radio emission that is likely associated with the optical counterparts. We found that 51 out of 846 radio core sources have extended emission (>4'' from the optical AGN) that is positively associated with the AGN, and we have identified an additional 12 AGNs with extended radio emission but no detectable radio core emission. Among these 63 AGNs, we found 6 giant radio galaxies, with projected emission exceeding 750 kpc in length, and several other AGNs with unusual radio morphologies also seen in higher redshift surveys. The optical spectra of many of the extended sources are similar to those of typical broad-line radio galaxy spectra, having broad H{alpha} emission lines with boxy profiles and large M{sub BH}. With extended emission taken into account, we find strong evidence for a bimodal distribution in the radio-loudness parameter R ({identical_to}{nu}{sub radio} L{sub radio}/{nu}{sub opt} L{sub opt}), where the lower radio luminosity core-only sources appear as a population separate from the extended sources, with a dividing line at log(R) {approx}1.75. This dividing line ensures that these are indeed the most radio-loud AGNs, which may have different or extreme physical conditions in their central engines when compared to the more numerous radio-quiet AGNs.

  16. 45 CFR 287.130 - Can NEW Program activities include job market assessments, job creation and economic development...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... assessments, job creation and economic development activities? 287.130 Section 287.130 Public Welfare... creation and economic development activities? (a) A Tribe may conduct job market assessments within its NEW Program. These might include the following: (1) Consultation with the Tribe's economic development...

  17. 45 CFR 287.130 - Can NEW Program activities include job market assessments, job creation and economic development...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... assessments, job creation and economic development activities? 287.130 Section 287.130 Public Welfare... creation and economic development activities? (a) A Tribe may conduct job market assessments within its NEW Program. These might include the following: (1) Consultation with the Tribe's economic development...

  18. 45 CFR 287.130 - Can NEW Program activities include job market assessments, job creation and economic development...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... assessments, job creation and economic development activities? 287.130 Section 287.130 Public Welfare... creation and economic development activities? (a) A Tribe may conduct job market assessments within its NEW Program. These might include the following: (1) Consultation with the Tribe's economic development...

  19. 45 CFR 287.130 - Can NEW Program activities include job market assessments, job creation and economic development...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... assessments, job creation and economic development activities? 287.130 Section 287.130 Public Welfare... creation and economic development activities? (a) A Tribe may conduct job market assessments within its NEW Program. These might include the following: (1) Consultation with the Tribe's economic development...

  20. 45 CFR 287.130 - Can NEW Program activities include job market assessments, job creation and economic development...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... assessments, job creation and economic development activities? 287.130 Section 287.130 Public Welfare... creation and economic development activities? (a) A Tribe may conduct job market assessments within its NEW Program. These might include the following: (1) Consultation with the Tribe's economic development...

  1. Activity of tigecycline tested against a global collection of Enterobacteriaceae, including tetracycline-resistant isolates.

    PubMed

    Fritsche, Thomas R; Strabala, Patty A; Sader, Helio S; Dowzicky, Michael J; Jones, Ronald N

    2005-07-01

    Steadily increasing resistance among the Enterobacteriaceae to beta-lactams, fluoroquinolones, aminoglycosides, tetracyclines, and trimethoprim/sulfamethoxazole has compromised the utility of these commonly used antimicrobial classes for many community- or hospital-acquired infections. The development of tigecycline, the sentinel representative of a novel class of broad-spectrum agents (the glycylcyclines), represents an important milestone in addressing this critical need. Resistance to tigecycline might be expected to occur via the same mechanisms that produce tetracycline resistance; however, tigecycline remains stable and largely unaffected by the commonly occurring efflux and ribosomal protection resistance mechanisms. In this study, an international collection of Enterobacteriaceae (11327 isolates; 32.8% tetracycline-resistant) from global surveillance studies (2000-2004) were evaluated against tigecycline and other comparator antimicrobials. Although the most active agents were the carbapenems and aminoglycosides (97.5-99.7% susceptible), tigecycline displayed high potency (MIC50 and MIC90, 0.25 and 1 microg/mL) with 95.7% of all strains being inhibited at < or =2 microg/mL. Despite higher MIC values observed with Serratia spp. and Proteae, between 90.5% and 97.5% of isolates were inhibited by < or =4 microg/mL of tigecycline. Tetracycline-resistant populations demonstrated only modest decreases in potency to tigecycline, which appeared to be species-dependent (up to 2-fold only for Escherichia coli, Salmonella spp., Shigella spp., and Panteoa agglomerans; and up to 4-fold for Klebsiella spp., Enterobacter spp., and Citrobacter spp.). Among E. coli (263 isolates) and Klebsiella spp. (356) that meet recognized screening definitions for extended-spectrum beta-lactamase production, 100.0% and 94.4% were inhibited by tigecycline at 2 microg/mL, respectively. These findings confirm that tigecycline exhibits potency, breadth of spectrum, and stability to the

  2. Guiding Learners to near Native Fluency in English through an Adaptive Programme of Activities Which Includes Phoneme and Prosody Analysis

    ERIC Educational Resources Information Center

    Lawson, Alistair; Attridge, Ann; Lapok, Paul

    2014-01-01

    Many students of English language find pronunciation difficult to master. This work in progress paper discusses an incremental and iterative approach towards developing requirements for software applications to assist learners with the perception and production of English pronunciation in terms of phonemes and prosody. It was found that prompts…

  3. Successful Approaches to Helping Students--Including English Learners--Succeed in Elementary School. Parent Guide = Enfoques exitosos para ayudar a los estudiantes--incluyendo a los que aprenden ingles--a triunfar en la escuela primaria. Guia de padres

    ERIC Educational Resources Information Center

    EdSource, 2007

    2007-01-01

    This guide informs parents about some instructional practices that work well for all elementary school students, in particular English learners. It includes questions parents can ask teachers and principals to help them understand how their children's school approaches teaching and learning. Both English and Spanish versions of the document are…

  4. Welder's Helper. Coordinator's Guide. Individualized Study Guide. General Metal Trades.

    ERIC Educational Resources Information Center

    Dean, James W.

    This guide provides information to enable coordinators to direct learning activities for students using an individualized study guide on being a welder's helper. The study material is designed for students enrolled in cooperative part-time training and employed, or desiring to be employed, as welders' helpers. Contents include a sample progress…

  5. Lathe Operator. Coordinator's Guide. Individualized Study Guide. General Metal Trades.

    ERIC Educational Resources Information Center

    East Texas State Univ., Commerce. Occupational Curriculum Lab.

    This guide provides information to enable coordinators to direct learning activities for students using an individualized study guide on operating a lathe. The study material is designed for students enrolled in cooperative part-time training and employed, or desiring to be employed, as lathe operators. Contents include a sample progress chart,…

  6. Should Physical Activity Be Included in Nutrition Education? A Comparison of Nutrition Outcomes with and without In-Class Activities

    ERIC Educational Resources Information Center

    Palmer-Keenan, Debra M.; Corda, Kirsten

    2014-01-01

    Limited-resource adults' dietary intakes and nutrition behaviors improve as a result of Expanded Food and Nutrition Education Program (EFNEP)/Supplemental Nutrition Assistance Program Education (SNAP-Ed) participation; however, physical activity education is needed for improved health. The experimental study reported here assessed if spending…

  7. An image-intensive ePR for image-guided minimally invasive spine surgery applications including real-time intra-operative image acquisition, archival, and display

    NASA Astrophysics Data System (ADS)

    Documet, Jorge R.; Le, Anh; Liu, Brent; Huang, H. K.; Chiu, John

    2009-02-01

    Recent developments in medical imaging informatics have improved clinical workflow in Radiology enterprise but gaps remain in the clinical workflow from diagnosis to surgical treatment through post-operative follow-up. One solution to bridge this gap is the development of an electronic patient record (ePR) that integrates key imaging and informatics data during the pre, intra, and post-operative phases of clinical workflow. We present an ePR system based on standards and tailored to the clinical application for image-guided minimally invasive spinal surgery (MISS). The ePR system has been implemented in a clinical environment for a half-year.

  8. Wind Energy Teachers Guide

    SciTech Connect

    anon.

    2003-01-01

    This guide, created by the American Wind Association, with support from the U.S. Department of Energy, is a learning tool about wind energy targeted toward grades K-12. The guide provides teacher information, ideas for sparking children's and students' interest, suggestions for activities to undertake in and outside the classroom, and research tools for both teachers and students. Also included is an additional resources section.

  9. DragonflyTV Teacher's Guides.

    ERIC Educational Resources Information Center

    Twin Cities Public Television, St. Paul, MN.

    This teacher's guide is based on "DragonflyTV" investigations which focus on real kids doing inquiry-based science investigations. Activities include: (1) "Investigation To Explore Skateboards"; (2) "Investigations To Explore Otters"; and (3) "Investigations To Explore Waterslides." (YDS)

  10. IK-guided PP2A suppresses Aurora B activity in the interphase of tumor cells.

    PubMed

    Lee, Sunyi; Jeong, Ae Lee; Park, Jeong Su; Han, Sora; Jang, Chang-Young; Kim, Keun Il; Kim, Yonghwan; Park, Jong Hoon; Lim, Jong-Seok; Lee, Myung Sok; Yang, Young

    2016-09-01

    Aurora B activation is triggered at the mitotic entry and required for proper microtubule-kinetochore attachment at mitotic phase. Therefore, Aurora B should be in inactive form in interphase to prevent aberrant cell cycle progression. However, it is unclear how the inactivation of Aurora B is sustained during interphase. In this study, we find that IK depletion-induced mitotic arrest leads to G2 arrest by Aurora B inhibition, indicating that IK depletion enhances Aurora B activation before mitotic entry. IK binds to Aurora B, and colocalizes on the nuclear foci during interphase. Our data further show that IK inhibits Aurora B activation through recruiting PP2A into IK and Aurora B complex. It is thus believed that IK, as a scaffold protein, guides PP2A into Aurora B to suppress its activity in interphase until mitotic entry. PMID:26906715

  11. Taoscore Teacher's Guides: Phase 4.

    ERIC Educational Resources Information Center

    Taos Municipal Schools, NM.

    A teacher's guide to six career education units--one for each of the elementary grades--has been compiled from a series of complete guides for each grade. Each of the six representative units includes step-by-step instructions for teacher activities in preparing and carrying out a simulated career experience; related curriculum concepts in math,…

  12. Ehanna Woyakapi (History). [Supplementary Guide].

    ERIC Educational Resources Information Center

    Sisseton-Wahpeton Sioux Tribe, Inc., SD.

    Designed as a supplementary guide to "History of the Sisseton-Wahpeton Sioux Tribe of the Lake Traverse Reservation" (1972 edition), this curriculum guide presents 12 elementary/secondary education units. Among the major items included in most units are concepts; behavioral objectives; vocabulary lists; activities and the materials needed for the…

  13. "Oliver Twist": A Teacher's Guide.

    ERIC Educational Resources Information Center

    Cashion, Carol; Fischer, Diana

    This teacher's guide for public television's 3-part adaptation of Charles Dickens's "Oliver Twist" provides information that will help enrich students' viewing of the series, whether or not they read the novel. The guide includes a wide range of discussion and activity ideas; there is also a series Web site and a list of Web resources.…

  14. Destination: Paraguay. Study Guide.

    ERIC Educational Resources Information Center

    Rhoades, Roxanne

    This guide offers a closer look at Paraguay as a landlocked republic in the heart of South America. The activities emphasize the interaction between the people and their land and pertain to three academic levels. Activities for grades 3-5 include: (1) "Packing for Paraguay"; (2) "Where in the World Are We Going and How in the World Will We Get…

  15. Westside Outdoor Teacher's Guide, Grades K-6.

    ERIC Educational Resources Information Center

    Brainard, Lynn; And Others

    This illustrated guide includes activities in Creative Arts, Language Arts, Math, Science, and Social Studies. Activities progress from an animal rhyme quiz for lower grades, to projects for upper level students on soil testing, relative humidity, and solar heat collection. The guide emphasizes activities selected to motivate students to…

  16. A Curriculum Activities Guide to Water Pollution and Environmental Studies, Volume I - Activities.

    ERIC Educational Resources Information Center

    Hershey, John T., Ed.; And Others

    This publication, Volume I of a two volume set, consists of many tested water pollution study activities. The activities are grouped into four headings: (1) Hydrologic Cycle, (2) Human Activities, (3) Ecological Perspectives, and (4) Social and Political Factors. Three levels of activities are provided: (1) those which increase awareness, (2)…

  17. Teacher's Guide for Earthworms.

    ERIC Educational Resources Information Center

    Bruno, Merle S.; And Others

    This teacher's guide on earthworms includes four major sections: (1) introduction, (2) caring for earthworms in the classroom, (3) classroom activities, and (4) the appendix. The introduction includes information concerning grade level, scheduling, materials, obtaining earthworms, field study, classroom clean-up, and records. Caring for earthworms…

  18. Nogales Dropout Prevention Guide.

    ERIC Educational Resources Information Center

    Nogales High School District 10, AZ.

    Descriptions of the Nogales dropout prevention program, including activities of the career counseling center and causes for dropping out of school, introduce the guide. The goals and objectives of the independent study center for potential dropouts include giving assistance to students so they may complete their high school education and guidance…

  19. Electrician's Helper. Coordinator's Guide. Individualized Study Guide.

    ERIC Educational Resources Information Center

    Stotts, Danny

    This guide is designed to assist teacher-coordinators supervising cooperative education programs for electrician's helpers in helping students complete a set of individualized, competency-based training activities dealing with electricity and electrical circuits and equipment. The first part of the manual includes a progress chart, a study guide…

  20. Guided inquiry activities for learning about the macro- and micronutrients in introductory nutrition courses.

    PubMed

    Smith, Andri L; Purcell, Rebecca J; Vaughan, Joel M

    2015-01-01

    Most students enroll in general education introductory nutrition classes because they want to improve their diets in order to lose weight or enhance athletic performance. These nonscience majors are often less interested in learning about the fundamental biochemical principles underlying nutrition or are surprised that this foundational knowledge of biochemistry is essential for appropriate diet planning. Furthermore, nonscience majors sometimes find traditional, lecture-oriented science classes that encourage competition rather than collaboration to be uninviting and unappealing. For these reasons, we have developed a set of guided inquiry activities about macronutrients (carbohydrates, lipids, and proteins) and micronutrients (vitamins and minerals) for use in introductory nutrition courses for nonscience majors. In our first study (Spring 2012), we divided students into two groups with two different approaches for learning about the macronutrients: (1) a traditional, lecture-based approach and (2) an active learning approach with guided inquiry activities. We showed through the use of embedded common exam questions that students mastered concepts related to the macronutrients equally well using either approach. Due to positive student and faculty feedback from the first study, we decided to have all students use the guided inquiry approach in a subsequent study the following year (Spring 2013). In our second study we used pre/post survey data to evaluate both students' concept mastery and confidence in answering questions about the macro- and micronutrients. We found that (1) students showed gains in both concept mastery and confidence and (2) as students' confidence increased, post-test concept scores also increased. PMID:26444445

  1. Activation of Visuomotor Systems during Visually Guided Movements: A Functional MRI Study

    NASA Astrophysics Data System (ADS)

    Ellermann, Jutta M.; Siegal, Joel D.; Strupp, John P.; Ebner, Timothy J.; Ugurbil, Kâmil

    1998-04-01

    The dorsal stream is a dominant visuomotor pathway that connects the striate and extrastriate cortices to posterior parietal areas. In turn, the posterior parietal areas send projections to the frontal primary motor and premotor areas. This cortical pathway is hypothesized to be involved in the transformation of a visual input into the appropriate motor output. In this study we used functional magnetic resonance imaging (fMRI) of the entire brain to determine the patterns of activation that occurred while subjects performed a visually guided motor task. In nine human subjects, fMRI data were acquired on a 4-T whole-body MR system equipped with a head gradient coil and a birdcage RF coil using aT*2-weighted EPI sequence. Functional activation was determined for three different tasks: (1) a visuomotor task consisting of moving a cursor on a screen with a joystick in relation to various targets, (2) a hand movement task consisting of moving the joystick without visual input, and (3) a eye movement task consisting of moving the eyes alone without visual input. Blood oxygenation level-dependent (BOLD) contrast-based activation maps of each subject were generated using period cross-correlation statistics. Subsequently, each subject's brain was normalized to Talairach coordinates, and the individual maps were compared on a pixel by pixel basis. Significantly activated pixels common to at least four out of six subjects were retained to construct the final functional image. The pattern of activation during visually guided movements was consistent with the flow of information from striate and extrastriate visual areas, to the posterior parietal complex, and then to frontal motor areas. The extensive activation of this network and the reproducibility among subjects is consistent with a role for the dorsal stream in transforming visual information into motor behavior. Also extensively activated were the medial and lateral cerebellar structures, implicating the cortico

  2. Simple control-theoretic models of human steering activity in visually guided vehicle control

    NASA Technical Reports Server (NTRS)

    Hess, Ronald A.

    1991-01-01

    A simple control theoretic model of human steering or control activity in the lateral-directional control of vehicles such as automobiles and rotorcraft is discussed. The term 'control theoretic' is used to emphasize the fact that the model is derived from a consideration of well-known control system design principles as opposed to psychological theories regarding egomotion, etc. The model is employed to emphasize the 'closed-loop' nature of tasks involving the visually guided control of vehicles upon, or in close proximity to, the earth and to hypothesize how changes in vehicle dynamics can significantly alter the nature of the visual cues which a human might use in such tasks.

  3. Activity-guided isolation of cytotoxic bis-bibenzyl constituents from Dumortiera hirsuta.

    PubMed

    Toyota, Masao; Ikeda, Risa; Kenmoku, Hiromichi; Asakawa, Yoshinori

    2013-01-01

    Activity-guided fractionation of the ether extract of Dumortiera hirsute (Japanese liverwort), using cytotoxicity testing with cultured HL 60 and KB cells, resulted in the isolation of a new cytotoxic bis-bibenzyl compound, along with the two known bis-bibenzyls: isomarchantin C and isoriccardin C. The structural determination of the new bis-bibenzyl through extensive NMR spectral data indicated a derivative of marchantin A, which has been isolated from the liverwort Marchantia polymorpha. The cytotoxicity of the bis-bibenzyls was evaluated by the MTT (3-(4,5-di-methylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay using cultured HL 60 and KB cells. PMID:23391534

  4. Real-time active MR-tracking of metallic stylets in MR-guided radiation therapy

    PubMed Central

    Wang, Wei; Dumoulin, Charles L.; Viswanathan, Akila N.; Tse, Zion T. H.; Mehrtash, Alireza; Loew, Wolfgang; Norton, Isaiah; Tokuda, Junichi; Seethamraju, Ravi T.; Kapur, Tina; Damato, Antonio L.; Cormack, Robert A.; Schmidt, Ehud J.

    2014-01-01

    Purpose To develop an active MR-tracking system to guide placement of metallic devices for radiation therapy. Methods An actively tracked metallic stylet for brachytherapy was constructed by adding printed-circuit micro-coils to a commercial stylet. The coil design was optimized by electromagnetic simulation, and has a radio-frequency lobe pattern extending ~5 mm beyond the strong B0 inhomogeneity region near the metal surface. An MR-tracking sequence with phase-field dithering was used to overcome residual effects of B0 and B1 inhomogeneities caused by the metal, as well as from inductive coupling to surrounding metallic stylets. The tracking system was integrated with a graphical workstation for real-time visualization. 3T MRI catheter-insertion procedures were tested in phantoms and ex-vivo animal tissue, and then performed in three patients during interstitial brachytherapy. Results The tracking system provided high-resolution (0.6 × 0.6 × 0.6 mm3) and rapid (16 to 40 frames per second, with three to one phase-field dithering directions) catheter localization in phantoms, animals, and three gynecologic cancer patients. Conclusion This is the first demonstration of active tracking of the shaft of metallic stylet in MR-guided brachytherapy. It holds the promise of assisting physicians to achieve better targeting and improving outcomes in interstitial brachytherapy. PMID:24903165

  5. Graphic Arts--Offset Press Operator/Duplicating Machine. TI-622. Instructor's Manual and Student Learning Activity Guide.

    ERIC Educational Resources Information Center

    Michelsen, Robert F.

    This instructor's manual and student learning activity guide comprise a kit for a graphic arts activity on offset press operator/duplicating machine. Purpose stated for the activity is to provide the student with an understanding of the basic operation involved in the production of printed matter in the graphic communications industry through the…

  6. Alcohol and Alcohol Safety. Volume II of II. A Curriculum Manual for Elementary Level. A Teacher's Activities Guide.

    ERIC Educational Resources Information Center

    Finn, Peter; Platt, Judith

    This curriculum manual for the elementary school level is the first in a series on alcohol and alcohol safety and is designed as a teacher's activities guide. Each activity provided is a self-contained learning experience which requires varying numbers of class period and focuses on one or more objectives. Activities are numbered consecutively and…

  7. Agriculture--Forestry, Biltmore Stick. Kit No. AG-107. Instructor's Manual and Student Learning Activity Guide. Revised.

    ERIC Educational Resources Information Center

    Simms, Barron; Johnson, Boston

    This two-volume set, consisting of an instructor's manual and a student learning activity guide, is designed for use in teaching vocational agriculture students basic forestry skills. Provided in the instructor's manual are guidelines concerning the duration of the activity; activity goals; a list of instructional objectives; a list of vocational…

  8. Bioassay-Guided Isolation of Compounds from Datura stramonium with TRAIL-Resistance Overcoming Activity.

    PubMed

    Karmakar, Utpal K; Toume, Kazufumi; Ishikawa, Naoki; Arai, Midori A; Sadhu, Samir K; Ahmed, Firoj; Ishibashi, Masami

    2016-02-01

    TRAIL is a potent inducer of apoptosis in most cancer cells, but not in normal cells, and therefore has deserved intense interest as a promising agent for cancer therapy. In the search for bioactive natural products for overcoming TRAIL-resistance, we previously reported a number of active compounds. In our screening program on natural resources targeting overcoming TRAIL-resistance, activity-guided fractionation of the MeOH extract of Datura stramonium leaves led to the isolation of three alkaloids--scopolamine (1), trigonelline (2), and tyramine (3). Compounds 1, 2, and 3 exhibited TRAIL-resistance overcoming activity at 50, 150, and 100 µM, respectively in TRAIL-resistant AGS cells. PMID:27032197

  9. Multiple Active Contours Guided by Differential Evolution for Medical Image Segmentation

    PubMed Central

    Cruz-Aceves, I.; Avina-Cervantes, J. G.; Lopez-Hernandez, J. M.; Rostro-Gonzalez, H.; Garcia-Capulin, C. H.; Torres-Cisneros, M.; Guzman-Cabrera, R.

    2013-01-01

    This paper presents a new image segmentation method based on multiple active contours guided by differential evolution, called MACDE. The segmentation method uses differential evolution over a polar coordinate system to increase the exploration and exploitation capabilities regarding the classical active contour model. To evaluate the performance of the proposed method, a set of synthetic images with complex objects, Gaussian noise, and deep concavities is introduced. Subsequently, MACDE is applied on datasets of sequential computed tomography and magnetic resonance images which contain the human heart and the human left ventricle, respectively. Finally, to obtain a quantitative and qualitative evaluation of the medical image segmentations compared to regions outlined by experts, a set of distance and similarity metrics has been adopted. According to the experimental results, MACDE outperforms the classical active contour model and the interactive Tseng method in terms of efficiency and robustness for obtaining the optimal control points and attains a high accuracy segmentation. PMID:23983809

  10. Astrocytic Ca2+ Waves Guide CNS Growth Cones to Remote Regions of Neuronal Activity

    PubMed Central

    Hung, Johanna; Colicos, Michael A.

    2008-01-01

    Activity plays a critical role in network formation during developmental, experience-dependent, and injury related remodeling. Here we report a mechanism by which axon trajectory can be altered in response to remote neuronal activity. Using photoconductive stimulation to trigger high frequency action potentials in rat hippocampal neurons in vitro, we find that activity functions as an attractive cue for growth cones in the local environment. The underlying guidance mechanism involves astrocyte Ca2+ waves, as the connexin-43 antagonist carbenoxolone abolishes the attraction when activity is initiated at a distance greater than 120 µm. The asymmetric growth cone filopodia extension that precedes turning can be blocked with CNQX (10 µM), but not with the ATP and adenosine receptor antagonists suramin (100 µM) and alloxazine (4 µM), suggesting non-NMDA glutamate receptors on the growth cone mediate the interaction with astrocytes. These results define a potential long-range signalling pathway for activity-dependent axon guidance in which growth cones turn towards directional, temporally coordinated astrocyte Ca2+ waves that are triggered by neuronal activity. To assess the viability of the guidance effect in an injury paradigm, we performed the assay in the presence of conditioned media from lipopolysaccharide (LPS) activated purified microglial cultures, as well as directly activating the glia present in our co-cultures. Growth cone attraction was not inhibited under these conditions, suggesting this mechanism could be used to guide regeneration following axonal injury. PMID:19002247

  11. Astrocytic Ca(2+) waves guide CNS growth cones to remote regions of neuronal activity.

    PubMed

    Hung, Johanna; Colicos, Michael A

    2008-01-01

    Activity plays a critical role in network formation during developmental, experience-dependent, and injury related remodeling. Here we report a mechanism by which axon trajectory can be altered in response to remote neuronal activity. Using photoconductive stimulation to trigger high frequency action potentials in rat hippocampal neurons in vitro, we find that activity functions as an attractive cue for growth cones in the local environment. The underlying guidance mechanism involves astrocyte Ca(2+) waves, as the connexin-43 antagonist carbenoxolone abolishes the attraction when activity is initiated at a distance greater than 120 microm. The asymmetric growth cone filopodia extension that precedes turning can be blocked with CNQX (10 microM), but not with the ATP and adenosine receptor antagonists suramin (100 microM) and alloxazine (4 microM), suggesting non-NMDA glutamate receptors on the growth cone mediate the interaction with astrocytes. These results define a potential long-range signalling pathway for activity-dependent axon guidance in which growth cones turn towards directional, temporally coordinated astrocyte Ca(2+) waves that are triggered by neuronal activity. To assess the viability of the guidance effect in an injury paradigm, we performed the assay in the presence of conditioned media from lipopolysaccharide (LPS) activated purified microglial cultures, as well as directly activating the glia present in our co-cultures. Growth cone attraction was not inhibited under these conditions, suggesting this mechanism could be used to guide regeneration following axonal injury. PMID:19002247

  12. Recycling Study Guide [and] The Fourth "R": An Action Booklet for Recycling in the Classroom and School [and] Nature's Recyclers: Activity Guide [and] K-3 Supplement to the Recycling Study Guide.

    ERIC Educational Resources Information Center

    Hallowell, Anne, Ed.; And Others

    Educators and educational institutions are frequently called upon to address issues when behavioral changes are needed. Solid waste is no exception. These four study guides contain activities and resources intended to help instructors and students understand what solid waste is, where it comes from, why it's a problem, and what can be done about…

  13. 25 CFR 170.623 - How are IRR Program projects and activities included in a self-governance agreement?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... other information required under 25 CFR 1000 subpart K. ... self-governance agreement? 170.623 Section 170.623 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE... self-governance agreement? To include an IRR Program project or activity in a self-governance...

  14. Effects of Leisure Education Programme Including Sportive Activities on Perceived Freedom in Leisure of Adolescents with Intellectual Disabilities

    ERIC Educational Resources Information Center

    Ertuzun, Ezgi

    2015-01-01

    The objective of this experimental study is to determine the effect of leisure education programme including sportive activities on the perceived freedom in leisure of adolescents with mild intellectual disabilities. The research was designed with an experimental group (n = 37) and a control group (n = 34), and was conducted among a total of 71…

  15. 25 CFR 170.137 - What types of activities can a recreation, tourism, and trails program include?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false What types of activities can a recreation, tourism, and trails program include? 170.137 Section 170.137 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN RESERVATION ROADS PROGRAM Indian Reservation Roads Program Policy and Eligibility Recreation, Tourism and Trails...

  16. 25 CFR 170.623 - How are IRR Program projects and activities included in a self-governance agreement?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... other information required under 25 CFR 1000 subpart K. ... self-governance agreement? 170.623 Section 170.623 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE... self-governance agreement? To include an IRR Program project or activity in a self-governance...

  17. 25 CFR 170.623 - How are IRR Program projects and activities included in a self-governance agreement?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... other information required under 25 CFR 1000 subpart K. ... self-governance agreement? 170.623 Section 170.623 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE... self-governance agreement? To include an IRR Program project or activity in a self-governance...

  18. 25 CFR 170.623 - How are IRR Program projects and activities included in a self-governance agreement?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... other information required under 25 CFR 1000 subpart K. ... self-governance agreement? 170.623 Section 170.623 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE... self-governance agreement? To include an IRR Program project or activity in a self-governance...

  19. 25 CFR 170.623 - How are IRR Program projects and activities included in a self-governance agreement?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... other information required under 25 CFR 1000 subpart K. ... self-governance agreement? 170.623 Section 170.623 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE... self-governance agreement? To include an IRR Program project or activity in a self-governance...

  20. Bioassay-Guided Isolation of Two Flavonoids from Derris scandens with Topoisomerase II Poison Activity.

    PubMed

    Sangmalee, Suphattra; Laorpaksa, Areerat; Sritularak, Boonchoo; Sukrong, Suchada

    2016-04-01

    Derris scandens (ROXB.) BENTH. (Fabaceae) is used as an alternative treatment for cancer in Thai traditional medicine. Investigation of the topoisomerase II (Top2) poison of compounds isolated from this plant may reveal new drug leads for the treatment of cancer. Bioassay-guided isolation was performed on an extract of D. scandens stems using a yeast cell-based assay. A yeast strain expressing the top2-1 temperature-sensitive mutant was used to assay Top2 activity. At the permissive temperature of 25°C, yeast cells were highly sensitive to Top2 poison agents. At the semi-permissive temperature of 30°C, where enzyme activity was present but greatly diminished, cells displayed only marginal sensitivity. The bioassay-guided fractionation of the extract led to the isolation of two known isoflavones: 5,7,4'-trihydroxy-6,8-diprenylisoflavone (1) and lupalbigenin (2). These two compounds also displayed cytotoxicity against three different cancer cell lines, KB, MCF-7 and NCI-H187. In conclusion, Top2 poison agents from D. scandens are reported for the first time, substantiating the use of D. scandens in Thai traditional medicine for cancer treatment. PMID:26754253

  1. Ceftaroline versus isolates from animal bite wounds: comparative in vitro activities against 243 isolates, including 156 Pasteurella species isolates.

    PubMed

    Goldstein, Ellie J C; Citron, Diane M; Merriam, C Vreni; Tyrrell, Kerin L

    2012-12-01

    More than 5 million Americans are bitten by animals, usually dogs, annually. Bite patients comprise ∼1% of all patients who visit emergency departments (300,000/year), and approximately 10,000 require hospitalization and intravenous antibiotics. Ceftaroline is the bioactive component of the prodrug ceftaroline fosamil, which is FDA approved for the treatment of acute bacterial skin and skin structure infections (ABSSSIs), including those containing methicillin-resistant Staphylococcus aureus (MRSA). There are no in vitro data about the activity of ceftaroline against Pasteurella multocida subsp. multocida and Pasteurella multocida subsp. septica, other Pasteurella spp., or other bite wound isolates. We therefore studied the in vitro activity of ceftaroline against 243 animal bite isolates. MICs were determined using the broth microdilution method according to CLSI guidelines. Comparator drugs included cefazolin, ceftriaxone, ertapenem, ampicillin-sulbactam, azithromycin, doxycycline, and sulfamethoxazole-trimethoprim (SMX-TMP). Ceftaroline was the most active agent against all 5 Pasteurella species, including P. multocida subsp. multocida and P. multocida subsp. septica, with a maximum MIC of ≤0.008 μg/ml; more active than ceftriaxone and ertapenem (MIC(90)s, ≤0.015 μg/ml); and more active than cefazolin (MIC(90), 0.5 μg/ml) doxycycline (MIC(90), 0.125 μg/ml), azithromycin (MIC(90), 0.5 μg/ml), ampicillin-sulbactam (MIC(90), 0.125 μg/ml), and SMX-TMP (MIC(90), 0.125 μg/ml). Ceftaroline was also very active against all S. aureus isolates (MIC(90), 0.125 μg/ml) and other Staphylococcus and Streptococcus species, with a maximum MIC of 0.125 μg/ml against all bite isolates tested. Ceftaroline has potential clinical utility against infections involving P. multocida, other Pasteurella species, and aerobic Gram-positive isolates, including S. aureus. PMID:23027193

  2. Ceftaroline versus Isolates from Animal Bite Wounds: Comparative In Vitro Activities against 243 Isolates, Including 156 Pasteurella Species Isolates

    PubMed Central

    Citron, Diane M.; Merriam, C. Vreni; Tyrrell, Kerin L.

    2012-01-01

    More than 5 million Americans are bitten by animals, usually dogs, annually. Bite patients comprise ∼1% of all patients who visit emergency departments (300,000/year), and approximately 10,000 require hospitalization and intravenous antibiotics. Ceftaroline is the bioactive component of the prodrug ceftaroline fosamil, which is FDA approved for the treatment of acute bacterial skin and skin structure infections (ABSSSIs), including those containing methicillin-resistant Staphylococcus aureus (MRSA). There are no in vitro data about the activity of ceftaroline against Pasteurella multocida subsp. multocida and Pasteurella multocida subsp. septica, other Pasteurella spp., or other bite wound isolates. We therefore studied the in vitro activity of ceftaroline against 243 animal bite isolates. MICs were determined using the broth microdilution method according to CLSI guidelines. Comparator drugs included cefazolin, ceftriaxone, ertapenem, ampicillin-sulbactam, azithromycin, doxycycline, and sulfamethoxazole-trimethoprim (SMX-TMP). Ceftaroline was the most active agent against all 5 Pasteurella species, including P. multocida subsp. multocida and P. multocida subsp. septica, with a maximum MIC of ≤0.008 μg/ml; more active than ceftriaxone and ertapenem (MIC90s, ≤0.015 μg/ml); and more active than cefazolin (MIC90, 0.5 μg/ml) doxycycline (MIC90, 0.125 μg/ml), azithromycin (MIC90, 0.5 μg/ml), ampicillin-sulbactam (MIC90, 0.125 μg/ml), and SMX-TMP (MIC90, 0.125 μg/ml). Ceftaroline was also very active against all S. aureus isolates (MIC90, 0.125 μg/ml) and other Staphylococcus and Streptococcus species, with a maximum MIC of 0.125 μg/ml against all bite isolates tested. Ceftaroline has potential clinical utility against infections involving P. multocida, other Pasteurella species, and aerobic Gram-positive isolates, including S. aureus. PMID:23027193

  3. Immunocontraceptive activity guided fractionation and characterization of active constituents of neem (Azadirachta indica) seed extracts.

    PubMed

    Garg, S; Talwar, G P; Upadhyay, S N

    1998-04-01

    A novel approach for immunocontraception by intervention of local cell mediated immunity in the reproductive system by using single intrauterine application of neem oil has been described earlier. The reversible block in fertility was reported to last for 107-180 days in female Wistar rats (Upadhyay et al., 1990. Antifertility effects of neem oil by single intrauterine administration: A novel method of contraception. Proceedings Of The Royal Society Of London B 242, 175-180) and 7-11 months in monkeys (Upadhyay et al., 1994. Long term contraceptive effects of intrauterine neem treatment (IUNT) in bonnet monkeys: An alternative to intrauterine contraceptive devices. Contraception 49, 161-167). The present study, describes the identification and characterization of the biologically active fraction from neem seeds (Azadirachta indica A. Juss. Family Meliaceae), responsible for the above activity in adult female Wistar rats. Initial studies with the mechanically extracted oil and solvent extracts of neem seeds have revealed that the antifertility activity was present in constituents of low to intermediate polarity. A hexane extract of neem seeds was reported to be biologically active (Garg et al., 1994. Comparison of extraction procedures on the immunocontraceptive activity of neem seed extracts. Journal of Ethnopharmacology 22, 87-92). Subsequently, hexane extract was sequentially fractionated through the last active fraction using various separation techniques and tested for antifertility activity at each step. Preparative HPLC was used for isolating individual components of the active fraction in quantities, sufficient for characterization. An analytical HPLC method was developed for standardization of the fraction. The active fraction was identified to be a mixture of six components, which comprises of saturated, mono and di-unsaturated free fatty acids and their methyl esters. Dose response study was performed with the last active fractions. The antifertility

  4. Colors of Competence in Competition: A Guide for Active Learning in Competitive Activities

    ERIC Educational Resources Information Center

    Bernstein, Eve; Rasmussen, Jennifer F.

    2013-01-01

    The idea of actively involving children in the learning process can be beneficial for both teacher and student on a number of levels. Allowing students in physical education class to make choices has been incorporated into elementary-age teaching successfully. As a way to invite students to become more active participants in their learning,…

  5. Teachers' Curriculum Guide to the Hayward Shoreline, K-12.

    ERIC Educational Resources Information Center

    Bachle, Leo; And Others

    This teaching guide gives environmental education ideas for grades K-12. The field trips and activities all relate to the Hayward shoreline of the San Francisco, California, Bay. Included in the guide are 44 science activities, 15 social science activities, and 18 humanities activities. Each activity description gives the experience level, site…

  6. Columbia County Kindergarten Center Environmental Study Area Guide.

    ERIC Educational Resources Information Center

    Florida State Dept. of Education, Tallahassee. Office of Environment Education.

    The guide lists seven program objectives and 15 activities guides for meeting the objectives. Included in each activity is an introduction, outdoor activity, classroom activity, and evaluation. Sample activities are: Animals Use Natural Materials to Provide Food and Shelter, Differences in Soil, Decomposition, Man-made or Natural Objects, Food…

  7. Move with Science: Energy, Force, & Motion. An Activities-Based Teacher's Guide.

    ERIC Educational Resources Information Center

    Beven, Roy Q.

    The secondary school level activities contained in this book use the subject of transportation to teach the basic concepts of physics and several areas of human biology. The material is organized into sections including curriculum design, activities, background readings, and resources. Activities focus on such topics as notions of motion stability…

  8. Island of the Sharks Activity Guide To Accompany the Large-Format Film.

    ERIC Educational Resources Information Center

    Gowell, Elizabeth Tayntor

    This document targets upper elementary and middle school students and provides activities to understand what the ocean floor looks like, the interactions of ocean communities, and the true nature of sharks. The activities are developed at three levels: beginner, intermediate, and advanced. The twelve activities include: (1) "Ocean Detectives"; (2)…

  9. Pond and Stream Safari: A Guide to the Ecology of Aquatic Invertebrates.

    ERIC Educational Resources Information Center

    Edelstein, Karen

    This packet includes a leader's guide, a quick reference guide to aquatic invertebrates, a checklist of common aquatic invertebrates, and activity sheets. The leader's guide includes four sections on background information and seven activities. Background sections include: Understanding Aquatic Insects; Growing Up: Aquatic Insect Forms; Adapting…

  10. Colostomy Guide

    MedlinePlus

    ... window. My Saved Articles » My ACS » Colostomy: A Guide Download Printable Version [PDF] » ( En español ) Colostomy surgery ... the activities you enjoyed in the past. This guide will help you better understand colostomy – what it ...

  11. 3...2...1...Liftoff!: An Educator's Guide with Activities in Science, Mathematics, Technology, and Language Arts.

    ERIC Educational Resources Information Center

    National Aeronautics and Space Administration, Washington, DC.

    This curriculum supplement introduces students in the early childhood classroom to the International Space Station and the role rockets play in its construction. The guide uses these topics as the basis for interdisciplinary activities for the early learner. Each activity features objectives, a material list, educator information, procedures, and…

  12. Geometry and Algebra: The Future Flight Equation. A Lesson Guide with Activities in Mathematics, Science, and Technology. NASA CONNECT.

    ERIC Educational Resources Information Center

    National Aeronautics and Space Administration, Hampton, VA. Langley Research Center.

    This activity, part of the NASA CONNECT Series, is designed to help students in grades 6-8 learn how NASA engineers develop experimental aircraft. It consists of an overview of the program, details of the hands-on activity, a series of blackline master student worksheets, teacher materials, and a guide to further resources. (MM)

  13. Feasibility and acceptability of remotely monitored pedometer-guided physical activity.

    PubMed

    Darvall, J N; Parker, A; Story, D A

    2016-07-01

    Nearly 70% of the Australian adult population are either sedentary, or have low levels of physical activity. There has been interest in addressing this problem by the 'mHealth', or mobile Health, arena, which is concerned with the confluence of mobile technology and health promotion. The newer generation of activity pedometers has the ability to automatically upload information, to enable aggregation and meta-data analysis of individual patient data. We conducted a ten-week pilot trial of the Fitbit Zip® pedometer using a validated tool in ten volunteers, finding it highly acceptable to both participants and investigators. Data synching was ranked as 'very easy' or 'easy' by all participants, and investigators could successfully monitor activity levels remotely. Median (interquartile range) daily step counts of participants over the ten-week trial ranged from 5471 (4591-7026) to 18779 (15031-21505) steps. Sedentary time over the study period ranged from 1.4% to 33.3% of study days. Percentage of days reaching the target activity level of >10,000 steps/day varied markedly between participants from 4.5% to 95.7%. This study demonstrates the feasibility and acceptability of a remotely monitored pedometer-guided physical activity intervention. This technology may be useful to encourage increased exercise as a form of 'prehabilitation' of adequately screened at-risk surgical or obstetric patients. PMID:27456182

  14. Business and Technology Concepts. Teacher's Guide.

    ERIC Educational Resources Information Center

    Illinois State Board of Education, Springfield. Dept. of Adult, Vocational and Technical Education.

    This curriculum guide is one of five developed as part of the Illinois Plan for Business, Marketing, and Management Education for use in 9th and 10th grades. The curriculum guide includes teacher and student activities that can be implemented in many ways. Information on how to integrate the activity objectives of the Illinois Plan into the State…

  15. Keyboarding, Typewriting and Formatting. Teacher's Guide.

    ERIC Educational Resources Information Center

    Illinois State Board of Education, Springfield. Dept. of Adult, Vocational and Technical Education.

    This curriculum guide is one of five developed as part of the Illinois Plan for Business, Marketing, and Management Education for use in 9th and 10th grades. The curriculum guide includes teacher and student activities that can be implemented in many ways. Information on how to integrate the activity objectives of the Illinois Plan into the State…

  16. A California Indian Resource Guide, 2003-2004. Activities and References for Teachers.

    ERIC Educational Resources Information Center

    2003

    This guide is intended for Bay Area (California) teachers who are interested in incorporating information on California Indians into their unit on California state history. The guide's purpose is to list resources in the Bay Area to help this unit come alive for students. Considerable care has been taken in the guide to choose only those resources…

  17. Amazing Soil Stories: Adventure and Activity Book [and] Teacher's Guide to the Activity Book.

    ERIC Educational Resources Information Center

    California Association of Resource Conservation Districts, Sacramento.

    The student activity book offers a variety of written exercises and "hands on" experiments and demonstrations for students at the fourth grade level. The book begins with a cartoon story that follows the adventures of a student investigating a soil erosion crisis and what her community can do to prevent soil erosion. Interspersed within the story…

  18. Active Galaxies Educational Unit: An Educator's Guide with Activities in Science and Mathematics.

    ERIC Educational Resources Information Center

    National Aeronautics and Space Administration, Washington, DC.

    As a part of its educational effort, the National Aeronautics and Space Administration (NASA) Education and Public Outreach group at Sonoma State University (SSU) has put together a series of activities based on the science of one of NASA's exciting space missions, the Gamma-ray Large Area Space Telescope (GLAST). GLAST is a NASA satellite planned…

  19. Continuing Spanish in Grade Four: MLA Teacher's Guide. A Course of Study Including Methods, Materials, and Aids for Teaching Conversational Spanish to Fourth-Grade Children.

    ERIC Educational Resources Information Center

    Thompson, Mary P.; And Others

    This is the second volume in a series of texts in a conversational Spanish course for elementary school children. Fourteen basic units present introductory linguistic patterns and cultural insights into the lives of the Spanish people. They include: (1) Review Unit 1, (2) Review Unit 2, (3) Special Unit A--"Cristobal Colon," (4) Review Unit 3, (5)…

  20. Curriculum Guide for Parent Education Programs (Including Special Sections for Rural Parents, Single Parents, Working Parents, and High Risk Parents). Columbia Basin College Parent Education Program.

    ERIC Educational Resources Information Center

    Hare, Jo Ann; And Others

    This curriculum for parent education through cooperative preschools has a sequential approach, with topics developed for parents with different age children enrolled in the various laboratory settings. Introductory materials include the goals and objectives for community college parent cooperative programs, methods of presentation, and a…

  1. Hydrologic Evaluation of Landfill Performance (HELP) Model: B (Set Includes, A- User's Guide for Version 3 w/disks, B-Engineering Documentation for Version 3

    EPA Science Inventory

    The Hydrologic Evaluation of Landfill Performance (HELP) computer program is a quasi-two-dimensional hydrologic model of water movement across, into, through and out of landfills. The model accepts weather, soil and design data. Landfill systems including various combinations o...

  2. Continuing Spanish in Grade Five: MLA Teacher's Guide. A Course of Study Including Methods, Materials, and Aids for Teaching Conversational Spanish to Fifth-Grade Children.

    ERIC Educational Resources Information Center

    Thompson, Mary P.; And Others

    This is the third volume in a series of texts in a conversational Spanish course for elementary school children. Nine basic units present introductory linguistic patterns and cultural insights into the lives of the Spanish people. They include: (1) Review Unit 1, ("Cristobal Colon"), (2) Review Unit 2, (3) "Un Accidente,""La Navidad," and…

  3. Beginning Spanish in Grade Three: MLA Teacher's Guide. A Course of Study Including Methods, Materials, and Aids for Teaching Conversational Spanish to Third-Grade Children.

    ERIC Educational Resources Information Center

    Thompson, Mary P.; And Others

    This is the first in a series of texts in a conversational Spanish course for elementary school children. Fifteen basic units present introductory linguistic patterns and cultural insights into the lives of Spaniards. They include: (1) Greetings, Identifications, and Farewells, (2) Some Classroom Objects and Instructions, (3) Colors, (4) More…

  4. Antioxidant activity-guided separation of coumarins and lignan from Melicope glabra (Rutaceae).

    PubMed

    Kassim, Nur Kartinee; Rahmani, Mawardi; Ismail, Amin; Sukari, Mohd Aspollah; Ee, Gwendoline Cheng Lian; Nasir, Nadiah Md; Awang, Khalijah

    2013-08-15

    The ethyl acetate and methanol bark extracts of Melicope glabra were evaluated for their antioxidant capacities by 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity and β-carotene bleaching/linoleic acid system. Both extracts exhibited strong inhibition against the DPPH radical (IC50 values of 24.81 and 13.01 μg ml(-1), respectively) and strong antioxidant activity in β-carotene bleaching assay. Both samples were found to have high phenolic content with values of 39 and 44 mg GAE/g as indicated by Follin-Ciocalteau's reagent. Antioxidant TLC assay-guided isolation on the methanol extract led to the isolation of a new pyranocoumarin, glabranin (1), umbelliferone (2), scopoletin (3) and sesamin (4), and their structures were determined by spectroscopy. Compounds (1-3) showed significant activities on DPPH free radical with the IC50 of 240.20, 810.02 and 413.19 μg ml(-1), respectively. However, in β-carotene bleaching assay, sesamin (4) showed higher inhibitory activity (1 mg ml(-1), 95%) than glabranin (1) (1 mg ml(-1), 74%), whilst umbelliferone (2) and scopoletin (3) were slightly pro-oxidant. PMID:23561082

  5. An active system for visually-guided reaching in 3D across binocular fixations.

    PubMed

    Martinez-Martin, Ester; del Pobil, Angel P; Chessa, Manuela; Solari, Fabio; Sabatini, Silvio P

    2014-01-01

    Based on the importance of relative disparity between objects for accurate hand-eye coordination, this paper presents a biological approach inspired by the cortical neural architecture. So, the motor information is coded in egocentric coordinates obtained from the allocentric representation of the space (in terms of disparity) generated from the egocentric representation of the visual information (image coordinates). In that way, the different aspects of the visuomotor coordination are integrated: an active vision system, composed of two vergent cameras; a module for the 2D binocular disparity estimation based on a local estimation of phase differences performed through a bank of Gabor filters; and a robotic actuator to perform the corresponding tasks (visually-guided reaching). The approach's performance is evaluated through experiments on both simulated and real data. PMID:24672295

  6. An Active System for Visually-Guided Reaching in 3D across Binocular Fixations

    PubMed Central

    2014-01-01

    Based on the importance of relative disparity between objects for accurate hand-eye coordination, this paper presents a biological approach inspired by the cortical neural architecture. So, the motor information is coded in egocentric coordinates obtained from the allocentric representation of the space (in terms of disparity) generated from the egocentric representation of the visual information (image coordinates). In that way, the different aspects of the visuomotor coordination are integrated: an active vision system, composed of two vergent cameras; a module for the 2D binocular disparity estimation based on a local estimation of phase differences performed through a bank of Gabor filters; and a robotic actuator to perform the corresponding tasks (visually-guided reaching). The approach's performance is evaluated through experiments on both simulated and real data. PMID:24672295

  7. Bioassay-guided isolation of proanthocyanidins with antioxidant activity from peanut (Arachis hypogaea) skin by combination of chromatography techniques.

    PubMed

    Oldoni, Tatiane L C; Melo, Priscilla S; Massarioli, Adna P; Moreno, Ivani A M; Bezerra, Rosângela M N; Rosalen, Pedro L; da Silva, Gil V J; Nascimento, Andréa M; Alencar, Severino M

    2016-02-01

    Purification and bioassay-guided fractionation were employed to isolate proanthocyanidins with antioxidant activity from peanut skin (Arachis hypogaea Runner 886). The crude extract was prepared with acetone (60% v/v) and purified using chromatographic methods, including a semipreparative HPLC technique. As a result, two proanthocyanidins were isolated and identified using NMR, epicatechin-(2 β → O → 7, 4 β → 8)-catechin (proanthocyanidin A1) and epicatechin-(β → 2 O → 7, 4 β → 8)-epicatechin (proanthocyanidin A2). Despite the structural similarity, differences were observed in their antioxidant activity. Proanthocyanidin A1 proved to be more active, with EC50 value for DPPH radical scavenging of 18.25 μg/mL and reduction of Fe(3+)-TPTZ complex of 7.59 mmol/g, higher than that of synthetic antioxidant BHT. This compound evaluated by ABTS(+) was similar to that of natural quercetin. Therefore, peanut skin is an important source of bioactive compounds that may be used as a mild antioxidant for food preservation. PMID:26304352

  8. Turtle Geometry. Teacher's Guide.

    ERIC Educational Resources Information Center

    San Francisco State Univ., CA.

    This document is the sixth of seven units developed by the Math Network Curriculum Project. Each unit, designed to be a 2-week module, is a teacher's guide which includes detailed directions along with the courseware and software needed. Teacher intervention in the non-computer activities that begin each unit is required, and the consistent use of…

  9. Data Analysis. Teacher's Guide.

    ERIC Educational Resources Information Center

    San Francisco State Univ., CA.

    This document is the fifth of seven units developed by the Math Network Curriculum Project. Each unit, designed to be a 2-week module, is a teacher's guide which includes detailed directions along with the courseware and software needed. Teacher intervention in the non-computer activities that begin each unit is required, and the consistent use of…

  10. Business. Teacher's Guide.

    ERIC Educational Resources Information Center

    San Francisco State Univ., CA.

    This document is the third of seven units developed by the Math Network Curriculum Project. Each unit, designed to be a 2-week module, is a teacher's guide which includes detailed directions along with the courseware and software needed. Teacher intervention in the non-computer activities that begin each unit is required, and the consistent use of…

  11. Energy Sources, Teacher's Guide.

    ERIC Educational Resources Information Center

    Karplus, Robert

    The unit presented in this teacher's guide is the first of two developed for the fifth year in the Science Curriculum Improvement Study (SCIS) curriculum. Attention is focused on energy transfers involved in the interaction of matter in solid, liquid, and gaseous forms. The chapters are presented in six parts which include activities for reviewing…

  12. TRAHC Folklife Study Guides.

    ERIC Educational Resources Information Center

    Texarkana Regional Arts and Humanities Council, Inc., TX.

    Each of the seven study guides combined in this packet provides a lesson that includes a reading or descriptive narrative of the topic, along with teaching objectives, questions to consider, and suggested classroom activities. Topics covered are: (1) "Introduction to the Concept of Folklife"; (2) "Southern Gospel Music and Song"; (3) "No Brag,…

  13. Destination: Kyrgyzstan. Study Guide.

    ERIC Educational Resources Information Center

    Amundson, Kristen J.

    This guide offers a closer look at the newly-independent nation of Kyrgyzstan. The teaching materials focus on the history and culture of the nation, emphasize the influence of physical geography on culture, and explore the diversity found in this small country. Each lesson includes the geography standards linked to the activity, objectives,…

  14. Strategies. Teacher's Guide.

    ERIC Educational Resources Information Center

    San Francisco State Univ., CA.

    This document is the second of seven units developed by the Math Network Curriculum Project. Each unit, designed to be a 2-week module, is a teacher's guide which includes detailed directions along with the courseware and software needed. Teacher intervention in the non-computer activities that begin each unit is required, and the consistent use…

  15. The Living Ocean. SeaWiFS: Studying Ocean Color from Space. Teacher's Guide with Activities

    NASA Technical Reports Server (NTRS)

    1994-01-01

    This educational document, designed for grades 9 to 10, discusses the observation of oceans from space. Topics covered include ocean color, the role of phytoplankton, the carbon cycle, and the greenhouse effect. Activities and discussion questions are presented.

  16. Activity of Eravacycline against Enterobacteriaceae and Acinetobacter baumannii, Including Multidrug-Resistant Isolates, from New York City

    PubMed Central

    Abdallah, Marie; Olafisoye, Olawole; Cortes, Christopher; Urban, Carl; Landman, David

    2014-01-01

    Eravacycline demonstrated in vitro activity against a contemporary collection of more than 4,000 Gram-negative pathogens from New York City hospitals, with MIC50/MIC90 values, respectively, for Escherichia coli of 0.12/0.5 μg/ml, Klebsiella pneumoniae of 0.25/1 μg/ml, Enterobacter aerogenes of 0.25/1 μg/ml, Enterobacter cloacae 0.5/1 μg/ml, and Acinetobacter baumannii of 0.5/1 μg/ml. Activity was retained against multidrug-resistant isolates, including those expressing KPC and OXA carbapenemases. For A. baumannii, eravacycline MICs correlated with increased expression of the adeB gene. PMID:25534744

  17. Monolithic crystalline cladding microstructures for efficient light guiding and beam manipulation in passive and active regimes

    PubMed Central

    Jia, Yuechen; Cheng, Chen; Vázquez de Aldana, Javier R.; Castillo, Gabriel R.; Rabes, Blanca del Rosal; Tan, Yang; Jaque, Daniel; Chen, Feng

    2014-01-01

    Miniature laser sources with on-demand beam features are desirable devices for a broad range of photonic applications. Lasing based on direct-pump of miniaturized waveguiding active structures offers a low-cost but intriguing solution for compact light-emitting devices. In this work, we demonstrate a novel family of three dimensional (3D) photonic microstructures monolithically integrated in a Nd:YAG laser crystal wafer. They are produced by the femtosecond laser writing, capable of simultaneous light waveguiding and beam manipulation. In these guiding systems, tailoring of laser modes by both passive/active beam splitting and ring-shaped transformation are achieved by an appropriate design of refractive index patterns. Integration of graphene thin-layer as saturable absorber in the 3D laser structures allows for efficient passive Q-switching of tailored laser radiations which may enable miniature waveguiding lasers for broader applications. Our results pave a way to construct complex integrated passive and active laser circuits in dielectric crystals by using femtosecond laser written monolithic photonic chips. PMID:25100561

  18. Minds-On Audio-Guided Activities (MAGA): More Than Hearing and Better Than Seeing

    NASA Astrophysics Data System (ADS)

    Hancock, James Brian; Fornari, Marco

    2012-05-01

    Minds-On Audio-Guided Activities (MAGA) are podcast-delivered instruction designed to facilitate learning through all-body experiments. Instruction by MAGA has undergone preliminary testing in an introductory physics course at Central Michigan University. Topics are currently focused on mechanics and range from discovering the differences between distance and displacement to momentum to the Coriolis effect (see Table I). MAGA instruction emphasizes physical activity, encouraging learners to engage their bodies and minds simultaneously. It targets a combination of learning styles, stimulating group discussion by using technology familiar to the learners. MAGA should be used as either an introductory activity or as a supplemental experience for students, compared with creating an entire class around MAGA-style instruction. Average learning gain for the trial semesters shows certain MAGA-covered topics are more effective than others. Oral interviews designed to probe the effectiveness of MAGA as well as student attitudes indicate that MAGA may foster longer-term retention of concepts.

  19. Monolithic crystalline cladding microstructures for efficient light guiding and beam manipulation in passive and active regimes.

    PubMed

    Jia, Yuechen; Cheng, Chen; Vázquez de Aldana, Javier R; Castillo, Gabriel R; Rabes, Blanca del Rosal; Tan, Yang; Jaque, Daniel; Chen, Feng

    2014-01-01

    Miniature laser sources with on-demand beam features are desirable devices for a broad range of photonic applications. Lasing based on direct-pump of miniaturized waveguiding active structures offers a low-cost but intriguing solution for compact light-emitting devices. In this work, we demonstrate a novel family of three dimensional (3D) photonic microstructures monolithically integrated in a Nd:YAG laser crystal wafer. They are produced by the femtosecond laser writing, capable of simultaneous light waveguiding and beam manipulation. In these guiding systems, tailoring of laser modes by both passive/active beam splitting and ring-shaped transformation are achieved by an appropriate design of refractive index patterns. Integration of graphene thin-layer as saturable absorber in the 3D laser structures allows for efficient passive Q-switching of tailored laser radiations which may enable miniature waveguiding lasers for broader applications. Our results pave a way to construct complex integrated passive and active laser circuits in dielectric crystals by using femtosecond laser written monolithic photonic chips. PMID:25100561

  20. Healing Touch with Guided Imagery for PTSD in returning active duty military: a randomized controlled trial.

    PubMed

    Jain, Shamini; McMahon, George F; Hasen, Patricia; Kozub, Madelyn P; Porter, Valencia; King, Rauni; Guarneri, Erminia M

    2012-09-01

    Post-traumatic stress disorder (PTSD) remains a significant problem in returning military and warrants swift and effective treatment. We conducted a randomized controlled trial to determine whether a complementary medicine intervention (Healing Touch with Guided Imagery [HT+GI]) reduced PTSD symptoms as compared to treatment as usual (TAU) returning combat-exposed active duty military with significant PTSD symptoms. Active duty military (n = 123) were randomized to 6 sessions (within 3 weeks) of HT+GI vs. TAU. The primary outcome was PTSD symptoms; secondary outcomes were depression, quality of life, and hostility. Repeated measures analysis of covariance with intent-to-treat analyses revealed statistically and clinically significant reduction in PTSD symptoms (p < 0.0005, Cohen's d = 0.85) as well as depression (p < 0.0005, Cohen's d = 0.70) for HT+GI vs. TAU. HT+GI also showed significant improvements in mental quality of life (p = 0.002, Cohen's d = 0.58) and cynicism (p = 0.001, Cohen's d = 0.49) vs. TAU. Participation in a complementary medicine intervention resulted in a clinically significant reduction in PTSD and related symptoms in a returning, combat-exposed active duty military population. Further investigation of GT and biofield therapy approaches for mitigating PTSD in military populations is warranted. PMID:23025129

  1. Solar Energy Education. Humanities: activities and teacher's guide. Field test edition

    SciTech Connect

    Not Available

    1982-01-01

    Activities are outlined to introduce students to information on solar energy while performing ordinary classroom work. In this teaching manual solar energy is integrated with the humanities. The activities include such things as stories, newspapers, writing assignments, and art and musical presentations all filled with energy related terms. An energy glossary is provided. (BCS)

  2. Modified agar dilution susceptibility testing method for determining in vitro activities of antifungal agents, including azole compounds.

    PubMed Central

    Yoshida, T; Jono, K; Okonogi, K

    1997-01-01

    In vitro activities of antifungal agents, including azole compounds, against yeasts were easily determined by using RPMI-1640 agar medium and by incubating the plates in the presence of 20% CO2. The end point of inhibition was clear by this method, even in the case of azole compounds, because of the almost complete inhibition of yeast growth at high concentrations which permitted weak growth of some Candida strains by traditional methods. MICs obtained by the agar dilution method were similar to those obtained by the broth dilution method proposed by the National Committee for Clinical Laboratory Standards. PMID:9174197

  3. Optics: Light, Color, and Their Uses. An Educator's Guide With Activities In Science and Mathematics

    NASA Technical Reports Server (NTRS)

    2000-01-01

    This document includes information on the Chandra X-Ray Observatory, the Hubble Space Telescope, the Next Generation Space Telescope, Soft X-Ray Imager, and the Lightning Imaging System. Classroom activities from grades K-12 are included, focusing on light and color, using mirrors, lenses, prisms, and filters.

  4. A taxonomic guide to the fanworms (Sabellidae, Annelida) of Lizard Island, Great Barrier Reef, Australia, including new species and new records.

    PubMed

    Capa, María; Murray, Anna

    2015-01-01

    This comprehensive taxonomic work is the result of the study of fan worms (Sabellidae, Annelida) collected over the last 40 years from around the Lizard Island Archipelago, Great Barrier Reef, Australia. Some species described herein are commonly found in Lizard Island waters but had not previously been formally reported in the literature. Most species appear to be not particularly abundant, and few specimens have been collected despite the sampling effort in the area over this time period. After this study, the overall sabellid diversity of the archipelago has been greatly increased (by more than 650%). Before this revision, only four sabellid species had been recorded for Lizard Island, and in this paper we report 31 species, 13 of which belong to nominal species, six are formally described as new species (Euchone danieloi n. sp., Euchone glennoi n. sp., Jasmineira gustavoi n. sp., Megalomma jubata n. sp., Myxicola nana n. sp., and Paradialychone ambigua n. sp.), and the identity of 12 species is still unknown (those referred as cf. or sp.). Two species are newly recorded in Australia and two in Queensland. The invasive species Branchiomma bairdi is reported for the first time at Lizard Island. The genus Paradialychone is reported for Australia for the first time. Standardised descriptions, general photographs of live and/or preserved specimens and distribution data are provided for all species. New species descriptions are accompanied by detailed illustrations and exhaustive morphological information. A dichotomous key for sabellid identification is also included. PMID:26624068

  5. Increasing resource allocation and research into tobacco control activities: a comprehensive approach including primary prevention, treatment and brief intervention.

    PubMed

    Richmond, R

    1993-01-01

    The range of tobacco control activities should be viewed as essential parts of a complex multi-component puzzle. Intervention strategies designed to address tobacco control should be comprehensive and include both primary and secondary prevention activities and be multi-faceted and capable of bringing about change at both the individual and broader social and cultural levels. In this paper I argue for a mutually inclusive framework in which the various components contribute in important and different ways. I examine the prevalence of smoking and identify the high risk groups, then I examine the range of available strategies and present the evidence for their success. I discuss the primary prevention approaches such as warning labels, taxes, price increases, workplace bans, education in schools, mass media and self-help materials, as well as brief interventions and treatment strategies which are conducted at the worksite, general practice and specialized cessation clinics. The areas for future research are delineated for increased resource allocation and include: the best ways to disseminate brief interventions to smokers, methods to motivate smokers; training of health professionals to deliver brief interventions; enhancing quitting and access to existing treatment resources among specific disadvantaged minority groups, e.g. migrants, unemployed youth, the effect on smoking prevalence of warning labels on cigarette packets and price rises on cigarettes. PMID:16818330

  6. An Antimicrobial Metabolite from Bacillus sp.: Significant Activity Against Pathogenic Bacteria Including Multidrug-Resistant Clinical Strains

    PubMed Central

    Chalasani, Ajay G.; Dhanarajan, Gunaseelan; Nema, Sushma; Sen, Ramkrishna; Roy, Utpal

    2015-01-01

    In this study, the cell free modified tryptone soya broth (pH 7.4 ± 0.2) of Bacillus subtilis URID 12.1 showed significant antimicrobial activity against multidrug-resistant strains of Staphylococcus aureus, S. epidermidis, Streptococcus pyogenes and Enterococcus faecalis. The partially purified antimicrobial molecule was found to be resistant to extremes of pH and temperatures and also to higher concentrations of trypsin and proteinase K. The antimicrobial molecule was purified by a three-step method that included reversed-phase high performance liquid chromatography (RP-HPLC). The minimum inhibitory concentration (MIC) values were determined for 14 species of bacteria using a microbroth dilution technique. The HPLC-purified fraction showed the MICs ranging from 0.5 to 16 μg/ml for methicillin and vancomycin-resistant Staphylococcus aureus (MVRSA) and methicillin-resistant Staphylococcus epidermidis (MRSE) strains. The molecular mass of the antimicrobial compound was determined to be 842.37 Da. The same antimicrobial fraction showed negligible haemolytic activity against human red blood cells even at a concentration as high as 100 μg/ml. Because of its significant antimicrobial activity at low MIC values coupled with its non-haemolytic property, it may prove to be a novel antimicrobial lead molecule. PMID:26696963

  7. A Revised Guide for Improving Teacher Education in Human Rights.

    ERIC Educational Resources Information Center

    Phi Delta Kappa, Bloomington, IN. Commission of Education, Human Rights, and Responsibilities.

    This document serves as a guide for teacher education institutions and programs designed to prepare educators for meeting their responsibilities in the area of human rights and human relations. This second edition of the guide represents a substantial modification of the original guide, and includes many activities, experiences, and suggestions…

  8. A Young Person's Guide to Laumeier Sculpture Park.

    ERIC Educational Resources Information Center

    Lander, Janie Birdsall

    1988-01-01

    Discusses EXPLORER'S GUIDE: A YOUNG PERSON'S GUIDE TO LAUMEIER SCULPTURE PARK, a book written to introduce children and adults to the artwork displayed in this St. Louis, Missouri park. Describes activities included in the book and assesses the guide's instructional value for young people. (GEA)

  9. Office Occupations--General Clerical, Consumer. Kit No. 25. Instructor's Manual [and] Student Learning Activity Guide--Group Interaction.

    ERIC Educational Resources Information Center

    Campbell, Creola S.

    An instructor's manual and student activity guide on general clerical work related to the consumer market are provided in this set of prevocational education materials which focuses on the vocational area of office occupations. (This set of materials is one of ninety-two prevocational education sets arranged around a cluster of seven vocational…

  10. T & I--Graphic Arts, Silk Screen Printing. Kit No. 60. Instructor's Manual [and] Student Learning Activity Guide.

    ERIC Educational Resources Information Center

    Cope, George

    An instructor's manual and student activity guide on silk screen printing are provided in this set of prevocational education materials which focuses on the vocational area of trade and industry (graphic arts). (This set of materials is one of ninety-two prevocational sets arranged around a cluster of seven vocational offerings: agriculture, home…

  11. Agriculture--Agricultural Production 1, Seed Bed. Kit No. 6. Instructor's Manual [and] Student Learning Activity Guide.

    ERIC Educational Resources Information Center

    Sloan, Lee

    An instructor's manual and student activity guide on the seed bed are provided in this set of prevocational education materials which focuses on the vocational area of agriculture. (This set of materials is one of ninety-two prevocational education sets arranged around a cluster of seven vocational offerings: agriculture, home economics,…

  12. Energy Use and the Environment. Concepts & Activities for the Classroom: Mathematics Module. Environmental Education Supplementary Instructional Guide.

    ERIC Educational Resources Information Center

    Hawaii State Dept. of Education, Honolulu. Office of Instructional Services.

    As part of a comprehensive, interdisciplinary environmental education program for elementary and secondary education in Hawaii, this teaching guide provides a variety of energy education activities for secondary school mathematics. An extensive introduction outlines the total program and how it fits into the general education program and explains…

  13. A Curriculum Activities Guide to Birds, Bugs, Dogs, and Weather and Environmental Studies. Volume 5. 2nd Edition.

    ERIC Educational Resources Information Center

    Hershey, John T.; And Others

    This material is one publication of a series of documents available from the Institute for Environmental Education (Cleveland) and consists of a curriculum activities guide to birds, bugs, dogs, and weather and environmental studies. The first edition of this material was prepared by the Documentation Task Force of Project KARE, Philadelphia, and…

  14. Qualifying Work Activities in Louisiana: A Recruiter's Guide To Documenting Eligibility for Migrant Education. Louisiana Migrant Education Program.

    ERIC Educational Resources Information Center

    Louisiana State Dept. of Education, Baton Rouge. Bureau of Migrant Education.

    This manual was written as a guide for state migrant education recruiters who need to be familiar with the nature of seasonal and temporary work performed by Louisiana's migrating agricultural workers and fishing industry laborers. It is intended to teach recruiters about the agricultural and fishing activities necessary for raising and harvesting…

  15. Agriculture--Agriculture Science--Seed Germination. Kit No. 51. Instructor's Manual [and] Student Learning Activity Guide.

    ERIC Educational Resources Information Center

    Cooper, Samuel

    An instructor's manual and student activity guide on seed germination are provided in this set of prevocational education materials which focuses on the vocational area of agriculture. (This set of materials is one of ninety-two prevocational education sets arranged around a cluster of seven vocational offerings: agriculture, home economics,…

  16. 47 CFR 79.110 - Complaint procedures for user interfaces, menus and guides, and activating accessibility features...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 4 2014-10-01 2014-10-01 false Complaint procedures for user interfaces, menus and guides, and activating accessibility features on digital apparatus and navigation devices. 79.110... ACCESSIBILITY OF VIDEO PROGRAMMING Apparatus § 79.110 Complaint procedures for user interfaces, menus and...

  17. T & I--Small Engine Repair, the Ignition System. Kit No. 7. Instructor's Manual [and] Student Learning Activity Guide.

    ERIC Educational Resources Information Center

    Underwood, Earl

    An instructor's manual and student activity guide on the ignition system of small engines are provided in this set of prevocational education materials which focuses on the vocational area of trade and industry. (This set of materials is one of ninety-two prevocational education sets arranged around a cluster of seven vocational offerings:…

  18. Any Way You Cut It! Molehills Out of Mountains. A Resource and Activity Guide for the Developmentally Disabled.

    ERIC Educational Resources Information Center

    Barringer, M. D.; Kosal-Smither, C.

    A resource and activity guide for the developmentally disabled that focuses on fine motor skills is presented. Attention is directed to fine motor behavior during the first year (vision, grasp, and release and reaching), and behaviors developing at 13 months (the interaction of fine motor and cognitive skills). An introductory section considers…

  19. T & I--Drafting, Reading the Architect's Scale. Kit No. 16. Instructor's Manual [and] Student Learning Activity Guide.

    ERIC Educational Resources Information Center

    Jones, Philip

    An instructor's manual and student activity guide on reading the architect's scale and the metric scale are provided in this set of prevocational education materials which focuses on the vocational area of trade and industry (drafting). (This set of materials is one of ninety-two prevocational education sets arranged around a cluster of seven…

  20. SNAC: San Mateo Nutrition Activity Curriculum. "Swing Into Nutrition" (Staff In-Service Guide and Staff Workbook).

    ERIC Educational Resources Information Center

    San Mateo City Elementary School District, CA.

    This inservice training guide on nutrition activities for preschool and elementary school teachers consists of 14 lesson plans for two workshops and more than 20 related instructional handouts that can be copied for teachers. The first workshop for teachers provides a rationale for nutrition education ine elementary curriculum as well as…

  1. Mars Exploration: Is There Water on Mars? An Educator's Guide with Activities for Physical and Earth and Space Science.

    ERIC Educational Resources Information Center

    TERC, Cambridge, MA.

    This educator's guide discusses whether there is water on the planet Mars. The activities, written for grades 9-12, concern physical, earth, and space sciences. By experimenting with water as it changes state and investigating some effects of air pressure, students not only learn core ideas in physical science but can also deduce the water…

  2. Language, Ecology, and Families (L.E.A.F.): A Guide to K-3 Language/Ecology Activities.

    ERIC Educational Resources Information Center

    Janesville Joint District 1, WI.

    This Project L.E.A.F. guide to ecology and language development activities for the primary grades consists of separate sections for kindergarten and grade 1 and a combined section for grades 2 and 3. Project L.E.A.F.--Language, Environment (Ecology) and Families--involved 270 Wisconsin primary school students in a model program with three main…

  3. Home Economics--Food Services, Basic Cake Decorating. Kit No. 57. Instructor's Manual [and] Student Learning Activity Guide.

    ERIC Educational Resources Information Center

    Brevard, Eddie, Jr.

    An instructor's manual and student activity guide on basic cake decorating are provided in this set of prevocational education materials which focuses on the vocational area of home economics (food services). (This set of materials is one of ninety-two prevocational sets arranged around a cluster of seven vocational offerings: agriculture, home…

  4. The Clubbers' Guide: A Treasure Trove of Science Activities/A Treasure Hunt through Time and Space

    ERIC Educational Resources Information Center

    Howarth, Sue; Scott, Linda; Carter, Liz

    2013-01-01

    This issue of Clubbers' Guide contains an article written by Liz Carter, Senior Science Technician at the Warwick School, Redhill, Surrey (UK), describing some of the wide variety of science, technology, engineering and mathematics (STEM) based activities that her school puts on during an eight-day summer school in the holidays for…

  5. The NASA "Why?" Files: The Case of the "Wright" Invention. A Lesson Guide with Activities in Mathematics, Science, and Technology.

    ERIC Educational Resources Information Center

    National Aeronautics and Space Administration, Hampton, VA. Langley Research Center.

    This lesson guide for instruction of students in grades 3-5 contains activities in mathematics, science, and technology. The NASA "Why?" Files is a series of instructional programs consisting of broadcast, print, and online elements. Emphasizing standards-based instruction, Problem-Based Learning, and science as inquiry, the series seeks to…

  6. MainXchange in the Classroom: The New Internet Stock Market Game. Teacher's Guide and Student Activities.

    ERIC Educational Resources Information Center

    1998

    This teaching guide/student activities booklet, for grades 6-9 and 7-11, outlines an Internet-based stock exchange simulation that allows students to learn about the stock market in a fun format. The simulation (the "MainXchange") described in the booklet offers students the opportunity to engage in "real-life" investing, while exploring and…

  7. Identification of novel, in vivo active Chk1 inhibitors utilizing structure guided drug design

    PubMed Central

    Massey, Andrew J.; Stokes, Stephen; Browne, Helen; Foloppe, Nicolas; Fiumana, Andreá; Scrace, Simon; Fallowfield, Mandy; Bedford, Simon; Webb, Paul; Baker, Lisa; Christie, Mark; Drysdale, Martin J.; Wood, Mike

    2015-01-01

    Chk1 kinase is a critical component of the DNA damage response checkpoint especially in cancer cells and targeting Chk1 is a potential therapeutic opportunity for potentiating the anti-tumor activity of DNA damaging chemotherapy drugs. Fragment elaboration by structure guided design was utilized to identify and develop a novel series of Chk1 inhibitors culminating in the identification of V158411, a potent ATP-competitive inhibitor of the Chk1 and Chk2 kinases. V158411 abrogated gemcitabine and camptothecin induced cell cycle checkpoints, resulting in the expected modulation of cell cycle proteins and increased cell death in cancer cells. V158411 potentiated the cytotoxicity of gemcitabine, cisplatin, SN38 and camptothecin in a variety of p53 deficient human tumor cell lines in vitro, p53 proficient cells were unaffected. In nude mice, V158411 showed minimal toxicity as a single agent and in combination with irinotecan. In tumor bearing animals, V158411 was detected at high levels in the tumor with a long elimination half-life; no pharmacologically significant in vivo drug-drug interactions with irinotecan were identified through analysis of the pharmacokinetic profiles. V158411 potentiated the anti-tumor activity of irinotecan in a variety of human colon tumor xenograft models without additional systemic toxicity. These results demonstrate the opportunity for combining V158411 with standard of care chemotherapeutic agents to potentiate the therapeutic efficacy of these agents without increasing their toxicity to normal cells. Thus, V158411 would warrant further clinical evaluation. PMID:26437226

  8. Identification of novel, in vivo active Chk1 inhibitors utilizing structure guided drug design.

    PubMed

    Massey, Andrew J; Stokes, Stephen; Browne, Helen; Foloppe, Nicolas; Fiumana, Andreá; Scrace, Simon; Fallowfield, Mandy; Bedford, Simon; Webb, Paul; Baker, Lisa; Christie, Mark; Drysdale, Martin J; Wood, Mike

    2015-11-01

    Chk1 kinase is a critical component of the DNA damage response checkpoint especially in cancer cells and targeting Chk1 is a potential therapeutic opportunity for potentiating the anti-tumor activity of DNA damaging chemotherapy drugs. Fragment elaboration by structure guided design was utilized to identify and develop a novel series of Chk1 inhibitors culminating in the identification of V158411, a potent ATP-competitive inhibitor of the Chk1 and Chk2 kinases. V158411 abrogated gemcitabine and camptothecin induced cell cycle checkpoints, resulting in the expected modulation of cell cycle proteins and increased cell death in cancer cells. V158411 potentiated the cytotoxicity of gemcitabine, cisplatin, SN38 and camptothecin in a variety of p53 deficient human tumor cell lines in vitro, p53 proficient cells were unaffected. In nude mice, V158411 showed minimal toxicity as a single agent and in combination with irinotecan. In tumor bearing animals, V158411 was detected at high levels in the tumor with a long elimination half-life; no pharmacologically significant in vivo drug-drug interactions with irinotecan were identified through analysis of the pharmacokinetic profiles. V158411 potentiated the anti-tumor activity of irinotecan in a variety of human colon tumor xenograft models without additional systemic toxicity. These results demonstrate the opportunity for combining V158411 with standard of care chemotherapeutic agents to potentiate the therapeutic efficacy of these agents without increasing their toxicity to normal cells. Thus, V158411 would warrant further clinical evaluation. PMID:26437226

  9. Tracking Epithelial Cell Junctions in C. elegans Embryogenesis With Active Contours Guided by SIFT Flow

    PubMed Central

    Lee, Chen-Yu; Gonçalves, Monira; Chisholm, Andrew D.; Cosman, Pamela C.

    2015-01-01

    Quantitative analysis of cell shape in live samples is an important goal in developmental biology. Automated or semiautomated segmentation and tracking of cell nuclei has been successfully implemented in several biological systems. Segmentation and tracking of cell surfaces has been more challenging. Here, we present a new approach to tracking cell junctions in the developing epidermis of C. elegans embryos. Epithelial junctions as visualized with DLG-1::GFP form lines at the subapical circumference of differentiated epidermal cells and delineate changes in epidermal cell shape and position. We develop and compare two approaches for junction segmentation. For the first method (projection approach), 3-D cell boundaries are projected into 2D for segmentation using active contours with a nonintersecting force, and subsequently tracked using scale-invariant feature transform (SIFT) flow. The resulting 2-D tracked boundaries are then back-projected into 3-D space. The second method (volumetric approach) uses a 3-D extended version of active contours guided by SIFT flow in 3-D space. In both methods, cell junctions are manually located at the first time point and tracked in a fully automated way for the remainder of the video. Using these methods, we have generated the first quantitative description of ventral epidermal cell movements and shape changes during epidermal enclosure. PMID:24771564

  10. Water Worlds. 4-H Member's Guide M-5-18; 4-H Leaders Guide L-5-18.

    ERIC Educational Resources Information Center

    Hawkes, Janet E.; And Others

    This pocket folder of materials is designed to provide children aged 9 to 12 with an opportunity to explore and observe aquatic environments. The package includes a 4-H Leader's guide, member's guide, and supplementary materials. The leader's guide contains safety considerations, tips and techniques, and additional activities for getting started…

  11. Causes of Hunger: A User's Guide for Christian Congregations. Companion Guide to Causes of Hunger: Hunger 1995.

    ERIC Educational Resources Information Center

    Park, Susan Kay; Simmons, Jim

    This document is an interactive, intergenerational guide designed to help organize group or individual study of "Causes of Hunger." The guide includes activities, worship aids, Bible studies, and a resource list--all adapted for classes, weekend retreats, and evening meetings. The guide is divided into nine sessions to be used with a variety of…

  12. PITBUL: a physics-based modeling package for imaging and tracking of airborne targets for HEL applications including active illumination

    NASA Astrophysics Data System (ADS)

    Van Zandt, Noah R.; McCrae, Jack E.; Fiorino, Steven T.

    2013-05-01

    Aimpoint acquisition and maintenance is critical to high energy laser (HEL) system performance. This study demonstrates the development by the AFIT/CDE of a physics-based modeling package, PITBUL, for tracking airborne targets for HEL applications, including atmospheric and sensor effects and active illumination, which is a focus of this work. High-resolution simulated imagery of the 3D airborne target in-flight as seen from the laser position is generated using the HELSEEM model, and includes solar illumination, laser illumination, and thermal emission. Both CW and pulsed laser illumination are modeled, including the effects of illuminator scintillation, atmospheric backscatter, and speckle, which are treated at a first-principles level. Realistic vertical profiles of molecular and aerosol absorption and scattering, as well as optical turbulence, are generated using AFIT/CDE's Laser Environmental Effects Definition and Reference (LEEDR) model. The spatially and temporally varying effects of turbulence are calculated and applied via a fast-running wave optical method known as light tunneling. Sensor effects, for example blur, sampling, read-out noise, and random photon arrival, are applied to the imagery. Track algorithms, including centroid and Fitts correlation, as a part of a closed loop tracker are applied to the degraded imagery and scored, to provide an estimate of overall system performance. To gauge performance of a laser system against a UAV target, tracking results are presented as a function of signal to noise ratio. Additionally, validation efforts to date involving comparisons between simulated and experimental tracking of UAVs are presented.

  13. Antimicrobial characterisation of CEM-101 activity against respiratory tract pathogens, including multidrug-resistant pneumococcal serogroup 19A isolates.

    PubMed

    Farrell, David J; Sader, Helio S; Castanheira, Mariana; Biedenbach, Douglas J; Rhomberg, Paul R; Jones, Ronald N

    2010-06-01

    CEM-101 is a novel fluorinated macrolide-ketolide with potent activity against bacterial pathogens that are susceptible or resistant to other macrolide-lincosamide-streptogramin B (MLS(B))-ketolide agents. CEM-101 is being developed for oral and parenteral use in moderate to moderately severe community-acquired bacterial pneumonia. The objective of this study was to assess the activity of CEM-101 and comparators against contemporary respiratory tract infection (RTI) isolates. A worldwide sample of organisms was used, including Streptococcus pneumoniae [n=168; 59.3% erythromycin-resistant and 18 multidrug-resistant (MDR) serogroup 19A strains], Moraxella catarrhalis (n=21; 11 beta-lactamase positive), Haemophilus influenzae (n=100; 48 beta-lactamase positive), Haemophilus parainfluenzae and Haemophilus haemolyticus (n=12), and Legionella pneumophila (n=30). Testing and interpretation were performed using reference Clinical and Laboratory Standards Institute methods. CEM-101 was very potent against S. pneumoniae [minimum inhibitory concentration for 90% of the organisms (MIC90)=0.25 mg/L; highest MIC at 0.5 mg/L] and was 2- and > or =32-fold more active than telithromycin and clindamycin, respectively. CEM-101 also demonstrated potent activity against S. pneumoniae MDR-19A strains (MIC90=0.5 mg/L). CEM-101 was the most potent antimicrobial agent tested against L. pneumophila, with all MIC values at < or = 0.015 mg/L (telithromycin MIC90=0.03 mg/L). CEM-101 was as potent as azithromycin against Haemophilus spp. RTI pathogens (MIC90=2 mg/L), with no variations for beta-lactamase production. CEM-101 MIC values against M. catarrhalis were all at < or =0.5mg/L. Interestingly, CEM-101 potency was ca. 6 log(2) dilutions greater than telithromycin MIC results among 44 beta-haemolytic streptococci having telithromycin MICs > or = 2 mg/L. CEM-101 exhibited the greatest potency and widest spectrum of activity against RTI pathogens among the tested MLS(B)-ketolide agents

  14. Activities Using Process-Oriented Guided Inquiry Learning (POGIL) in the Foreign Language Classroom

    ERIC Educational Resources Information Center

    Johnson, Catherine

    2011-01-01

    Process-Oriented Guided Inquiry Learning (POGIL) is a method that requires students to work in small groups, view models or diagrams, and answer carefully designed questions that guide them to an understanding of the subject matter on their own, with minimal direction from the instructor. Several studies show that the method has been highly…

  15. Helping Children and Families through Legislative Activism: A Guide to the Legislative Process.

    ERIC Educational Resources Information Center

    Douglass, Adele; Winterfeld, Amy

    This guide to the legislative process provides information on how to work within the legislative process for changes benefiting children and families. The guide is divided into 5 major sections: (1) know the issues and know the state and congressional legislative systems; (2) know how to express an opinion; (3) communications from non-profit…

  16. Intermountain West Military Training Lands Planting Guide: Selecting Seed Mixtures for Actively Used Military Lands

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This guide provides recommendations on plant materials for Department of Defense (DoD) training land restoration at military facilities in the Intermountain West of the United States. These guidelines fill a gap in knowledge in the science of military land management; there are no other guides for ...

  17. Speech Activities in the Elementary School. Michigan Speech Association Curriculum Guide Series, No. 5.

    ERIC Educational Resources Information Center

    Heinig, Ruth M.

    The purpose of this guide is to aid teachers in elementary schools to incorporate speech instruction into the daily classroom schedule. Each of the 12 units in the guide contains lesson objectives, lesson topics, suggested learning experiences, a bibliography, a list of audiovisual materials, and suggestions for the development of the teacher's…

  18. Rockets: Educator's Guide with Activities in Science, Technology, Engineering and Mathematics

    ERIC Educational Resources Information Center

    Shearer, Deborah A.; Vogt, Gregory L.

    2008-01-01

    This guide provides teachers and students many opportunities. Chapters within the guide present the history of rocketry, National Aeronautics and Space Administration's (NASA's) 21st Century Space Exploration Policy, rocketry principles, and practical rocketry. These topics lay the foundation for what follows--a wealth of dynamic rocket science…

  19. Language: A Theme Guide to K-12 Curricular Resources, Activities, and Processes.

    ERIC Educational Resources Information Center

    Stanford Univ., CA. Stanford Program on International and Cross Cultural Education.

    This guide is for educators who wish to improve existing curricular frameworks about teaching about language. The guide is anchored by five goal statements for student learning: (1) to investigate the origin and early development of human communication systems; (2) to gain an appreciation for the rich variety of ways in which humans convey…

  20. Space Resources for Teachers, Space Science, A Guide Outlining Understandings, Fundamental Concepts, and Activities.

    ERIC Educational Resources Information Center

    Thompson, Malcolm

    This instructional and resource guide is designed so that it may be used in the secondary school or in the first two years of college to present a series of units in space science, or to supplement existing science and mathematics courses. The guide consists of six units: (1) measurement, distance, and size in astronomy, (2) atoms, spectra, and…

  1. Locating an active fault zone in Coso geothermal field by analyzing seismic guided waves from microearthquake data

    SciTech Connect

    SGP-TR-150-16

    1995-01-26

    Active fault systems usually provide high-permeability channels for hydrothermal outflow in geothermal fields. Locating such fault systems is of a vital importance to plan geothermal production and injection drilling, since an active fault zone often acts as a fracture-extensive low-velocity wave guide to seismic waves. We have located an active fault zone in the Coso geothermal field, California, by identifying and analyzing a fault-zone trapped Rayleigh-type guided wave from microearthquake data. The wavelet transform is employed to characterize guided-wave's velocity-frequency dispersion, and numerical methods are used to simulate the guided-wave propagation. The modeling calculation suggests that the fault zone is {approx} 200m wide, and has a P wave velocity of 4.80 km/s and a S wave velocity of 3.00 km/s, which is sandwiched between two half spaces with relatively higher velocities (P wave velocity 5.60 km/s, and S wave velocity 3.20 km/s). zones having vertical or nearly vertical dipping fault planes.

  2. Protrusive Activity Guides Changes in Cell-Cell Tension during Epithelial Cell Scattering

    PubMed Central

    Maruthamuthu, Venkat; Gardel, Margaret L.

    2014-01-01

    Knowing how epithelial cells regulate cell-matrix and cell-cell adhesions is essential to understand key events in morphogenesis as well as pathological events such as metastasis. During epithelial cell scattering, epithelial cell islands rupture their cell-cell contacts and migrate away as single cells on the extracellular matrix (ECM) within hours of growth factor stimulation, even as adhesion molecules such as E-cadherin are present at the cell-cell contact. How the stability of cell-cell contacts is modulated to effect such morphological transitions is still unclear. Here, we report that in the absence of ECM, E-cadherin adhesions continue to sustain substantial cell-generated forces upon hepatocyte growth factor (HGF) stimulation, consistent with undiminished adhesion strength. In the presence of focal adhesions, constraints that preclude the spreading and movement of cells at free island edges also prevent HGF-mediated contact rupture. To explore the role of cell motion and cell-cell contact rupture, we examine the biophysical changes that occur during the scattering of cell pairs. We show that the direction of cell movement with respect to the cell-cell contact is correlated with changes in the average intercellular force as well as the initial direction of cell-cell contact rupture. Our results suggest an important role for protrusive activity resulting in cell displacement and force redistribution in guiding cell-cell contact rupture during scattering. PMID:25099795

  3. Cell spreading analysis with directed edge profile-guided level set active contours.

    PubMed

    Ersoy, I; Bunyak, F; Palaniappan, K; Sun, M; Forgacs, G

    2008-01-01

    Cell adhesion and spreading within the extracellular matrix (ECM) plays an important role in cell motility, cell growth and tissue organization. Measuring cell spreading dynamics enables the investigation of cell mechanosensitivity to external mechanical stimuli, such as substrate rigidity. A common approach to measure cell spreading dynamics is to take time lapse images and quantify cell size and perimeter as a function of time. In our experiments, differences in cell characteristics between different treatments are subtle and require accurate measurements of cell parameters across a large population of cells to ensure an adequate sample size for statistical hypothesis testing. This paper presents a new approach to estimate accurate cell boundaries with complex shapes by applying a modified geodesic active contour level set method that directly utilizes the halo effect typically seen in phase contrast microscopy. Contour evolution is guided by edge profiles in a perpendicular direction to ensure convergence to the correct cell boundary. The proposed approach is tested on bovine aortic endothelial cell images under different treatments, and demonstrates accurate segmentation for a wide range of cell sizes and shapes compared to manual ground truth. PMID:18979769

  4. Event-related power modulations of brain activity preceding visually guided saccades.

    PubMed

    Brignani, Debora; Maioli, Claudio; Maria Rossini, Paolo; Miniussi, Carlo

    2007-03-01

    To analyze the characteristics of the event-related desynchronization (ERD) and synchronization (ERS) of cortical rhythms during the preparation and execution of a lateralized eye movement, EEG was recorded in normal subjects during a visually guided task. Alpha and beta bands were investigated in three temporal intervals: a sensory period, a delay period and a saccade preparation period time locked with saccade onset. Modulations of ERD/ERS power, coupled with the task, reached the largest amplitudes over the frontal and parieto-occipital regions. Differences of oscillatory activity in the alpha bands revealed an intriguing pattern of asymmetry in parieto-occipital areas. Rightward saccades induced a larger desynchronization with respect to the leftward saccades in the left hemisphere, but not in the right. If representative, these findings are congruent to the established right-hemisphere dominance of the brain areas that direct attention. Moreover differences between the two alpha types emerged in the frontal areas before and during the saccade preparation periods, indicative of differential engagement of these areas depending on the task demands. In conclusion, the present approach shows that planning eye movements is linked with covert orienting of spatial attention and may supply a useful method for studying eye movements and selective attention-related processes. PMID:17196943

  5. Texas Almanac Teacher's Guide, 1998-99.

    ERIC Educational Resources Information Center

    Dallas Morning News, TX.

    This teacher's guide utilizes the subject matter in the 1998-99 Texas Almanac in a variety of interdisciplinary student activities for grades 3-8. The guide includes a grade-by-grade curriculum chart detailing which lessons correspond to specific Texas Assessment of Academic Skills (TAAS) objectives and Essential Element requirements. The 45…

  6. Direct Loan Overview Workshop. Participant's Guide.

    ERIC Educational Resources Information Center

    Department of Education, Washington, DC.

    This training guide for a one-day workshop provides an introduction to the William D. Ford Federal Direct Loan Program for administrative personnel at higher educations institutions. The seven sections of the guide, each corresponding to a single workshop session, include activity sheets, questions for participants to answer, and space for notes.…

  7. CNN Newsroom Classroom Guides. October 1995.

    ERIC Educational Resources Information Center

    Cable News Network, Atlanta, GA.

    These classroom guides, designed to accompany the daily CNN (Cable News Network) Newsroom broadcasts for the month of October, provide program rundowns, suggestions for class activities and discussion, student handouts, and a list of related news terms. Topics covered by the guides include: bedroom community business, freedom of expression and…

  8. Aviation & Space Curriculum Guide K-3. Revised.

    ERIC Educational Resources Information Center

    Alabama State Dept. of Education, Montgomery.

    This guide is designed for teachers of grades K-3 who have little or no experience in the area of aviation or space. The purpose of this guide is to provide an array of aviation and space activities which may be used by teachers to enrich locally-designed programs. Units in this book include: (1) History of Aerospace; (2) Kinds and Uses of…

  9. The Worm Guide: A Vericomposting Guide for Teachers.

    ERIC Educational Resources Information Center

    California Integrated Waste Management Board, Sacramento.

    This guide focuses on vermicomposting of food waste. Contents include: (1) "Integrated Waste Management"; (2) "Basics of Vermicomposting"; (3) "Other Worm Bin Residents"; (4) "The Garden Connection"; (5) "Closing the Food Loop at Your School"; (6) "Fundraising"; (7) "Activities for Classroom"; and (8) "Case Studies". Appendices include educational…

  10. Indiana Reading Diagnostic Assessment: Resource & Intervention Guide, First Grade. Additional Activities and Assessments

    ERIC Educational Resources Information Center

    Indiana Department of Education, 2006

    2006-01-01

    The materials included in this manual are organized according to the Indiana Grade 1 Academic Standards for English/Language Arts. In each section teachers will find: (1) Indiana Grade 1 Academic Standards for English/Language Arts; (2) Assessments: diagnostic/practice pages for skill areas, checklists, and rubrics; (3) Classroom Activities:…

  11. Strategies for integrating computer-based activities into your educational environment: a practical guide.

    PubMed Central

    Miller, J G; Wolf, F M

    1996-01-01

    Strategies for implementing instructional technology are based on recent experiences at the University of Michigan Medical Center. The issues covered include 1) addressing facilities, hardware, and staffing needs, 2) determining learners' skill requirements and appropriate training activities, and 3) selecting and customizing educational software. Many examples are provided, and nine key points for success are emphasized. PMID:8653447

  12. Activated Biological Filters (ABF Towers). Instructor's Guide. Biological Treatment Process Control.

    ERIC Educational Resources Information Center

    Wooley, John F.

    This instructor's manual contains materials needed to teach a two-lesson unit on activated bio-filters (ABF). These materials include: (1) an overview of the two lessons; (2) lesson plans; (3) lecture outlines (keyed to a set of slides designed for use with the lessons); (4) overhead transparency masters; (5) worksheets for each lesson (with…

  13. Solar Energy Education. Social studies: activities and teacher's guide. Field test edition

    SciTech Connect

    Not Available

    1982-01-01

    Solar energy information is made available to students through classroom instruction by way of the Solar Energy Education teaching manuals. In this manual solar energy, as well as other energy sources like wind power, is introduced by performing school activities in the area of social studies. A glossary of energy related terms is included. (BCS)

  14. Patient Selection and Activity Planning Guide for Selective Internal Radiotherapy With Yttrium-90 Resin Microspheres

    SciTech Connect

    Lau, Wan-Yee; Kennedy, Andrew S.; Kim, Yun Hwan; Lai, Hee Kit; Lee, Rheun-Chuan; Leung, Thomas W.T.; Liu, Ching-Sheng; Salem, Riad; Sangro, Bruno; Shuter, Borys; Wang, Shih-Chang

    2012-01-01

    Purpose: Selective internal radiotherapy (SIRT) with yttrium-90 ({sup 90}Y) resin microspheres can improve the clinical outcomes for selected patients with inoperable liver cancer. This technique involves intra-arterial delivery of {beta}-emitting microspheres into hepatocellular carcinomas or liver metastases while sparing uninvolved structures. Its unique mode of action, including both {sup 90}Y brachytherapy and embolization of neoplastic microvasculature, necessitates activity planning methods specific to SIRT. Methods and Materials: A panel of clinicians experienced in {sup 90}Y resin microsphere SIRT was convened to integrate clinical experience with the published data to propose an activity planning pathway for radioembolization. Results: Accurate planning is essential to minimize potentially fatal sequelae such as radiation-induced liver disease while delivering tumoricidal {sup 90}Y activity. Planning methods have included empiric dosing according to degree of tumor involvement, empiric dosing adjusted for the body surface area, and partition model calculations using Medical Internal Radiation Dose principles. It has been recommended that at least two of these methods be compared when calculating the microsphere activity for each patient. Conclusions: Many factors inform {sup 90}Y resin microsphere SIRT activity planning, including the therapeutic intent, tissue and vasculature imaging, tumor and uninvolved liver characteristics, previous therapies, and localization of the microsphere infusion. The influence of each of these factors has been discussed.

  15. Our Mother Corn. Teacher's Guide.

    ERIC Educational Resources Information Center

    Mathers, Sherry; And Others

    Designed to accompany the preceding student text (which deals with the role of corn in the Seneca, Pawnee, and Hopi tribes), the teaching guide contains a suggested sequence of activities and needed supplementary information along with an indication of the student text they follow. Sections include: farming notes; basic needs activities; house…

  16. NOVA[R] Fall 2001 Teacher's Guide.

    ERIC Educational Resources Information Center

    WGBH-TV, Boston, MA.

    This teacher guide includes activity information for the program NOVA, Fall 2001. Background for each activity is provided along with its correlation to the national science standards. Activities include: (1) "Search for a Safe Cigarette"; (2) "18 Ways To Make a Baby"; (3) "Secrets of Mind"; (4) "Neanderthals on Trial"; (5) "Life's Greatest…

  17. Development and flight evaluation of active controls in the L-1011. [including wing load alleviation and stability augmentation

    NASA Technical Reports Server (NTRS)

    Johnston, J. F.; Urie, D. M.

    1978-01-01

    Active controls in the Lockheed L-1011 for increased energy efficiency are discussed. Active wing load alleviation for extended span, increased aspect ratio, and active stability augmentation with a smaller tail for reduced drag and weight are among the topics considered. Flight tests of active wing load alleviation on the baseline aircraft and moving-base piloted simulation developing criteria for stability augmentation are described.

  18. EGFR activating mutations correlate with a Fanconi anemia-like cellular phenotype that includes PARP inhibitor sensitivity

    PubMed Central

    Pfäffle, Heike N.; Wang, Meng; Gheorghiu, Liliana; Ferraiolo, Natalie; Greninger, Patricia; Borgmann, Kerstin; Settleman, Jeffrey; Benes, Cyril H.; Sequist, Lecia V.; Zou, Lee; Willers, Henning

    2013-01-01

    In lung cancer patients whose tumors harbor activating mutations in the epidermal growth factor receptor (EGFR), increased responses to platinum-based chemotherapies are seen compared to wild-type cancers. However, the mechanisms underlying this association have remained elusive. Here, we describe a cellular phenotype of crosslinker sensitivity in a subset of EGFR-mutant lung cancer cell lines that is reminiscent of the defects seen in cells impaired in the Fanconi Anemia pathway, including a pronounced G2/M cell-cycle arrest and chromosomal radial formation. We identified a defect downstream of FANCD2 at the level of recruitment of FAN1 nuclease and DNA interstrand crosslink (ICL) unhooking. The effect of EGFR mutation was epistatic with FANCD2. Consistent with the known role of FANCD2 in promoting RAD51 foci formation and homologous recombination repair (HRR), EGFR-mutant cells also exhibited an impaired RAD51 foci response to ICLs, but not to DNA double-strand breaks. EGFR kinase inhibition affected RAD51 foci formation neither in EGFR mutant nor wild-type cells. In contrast, EGFR depletion or overexpression of mutant EGFR in wild-type cells suppressed RAD51 foci, suggesting an EGFR kinase-independent regulation of DNA repair. Interestingly, EGFR-mutant cells treated with the PARP inhibitor olaparib also displayed decreased FAN1 foci induction, coupled with a putative block in a late HRR step. As a result, EGFR-mutant lung cancer cells exhibited olaparib sensitivity in-vitro and in-vivo. Our findings provide insight into the mechanisms of cisplatin and PARP inhibitor sensitivity of EGFR-mutant cells, yielding potential therapeutic opportunities for further treatment individualization in this genetically defined subset of lung cancer. PMID:23966292

  19. Discovery of novel polyamine analogs with anti-protozoal activity by computer guided drug repositioning.

    PubMed

    Alberca, Lucas N; Sbaraglini, María L; Balcazar, Darío; Fraccaroli, Laura; Carrillo, Carolina; Medeiros, Andrea; Benitez, Diego; Comini, Marcelo; Talevi, Alan

    2016-04-01

    Chagas disease is a parasitic infection caused by the protozoa Trypanosoma cruzi that affects about 6 million people in Latin America. Despite its sanitary importance, there are currently only two drugs available for treatment: benznidazole and nifurtimox, both exhibiting serious adverse effects and limited efficacy in the chronic stage of the disease. Polyamines are ubiquitous to all living organisms where they participate in multiple basic functions such as biosynthesis of nucleic acids and proteins, proliferation and cell differentiation. T. cruzi is auxotroph for polyamines, which are taken up from the extracellular medium by efficient transporters and, to a large extent, incorporated into trypanothione (bis-glutathionylspermidine), the major redox cosubstrate of trypanosomatids. From a 268-compound database containing polyamine analogs with and without inhibitory effect on T. cruzi we have inferred classificatory models that were later applied in a virtual screening campaign to identify anti-trypanosomal compounds among drugs already used for other therapeutic indications (i.e. computer-guided drug repositioning) compiled in the DrugBank and Sweetlead databases. Five of the candidates identified with this strategy were evaluated in cellular models from different pathogenic trypanosomatids (T. cruzi wt, T. cruzi PAT12, T. brucei and Leishmania infantum), and in vitro models of aminoacid/polyamine transport assays and trypanothione synthetase inhibition assay. Triclabendazole, sertaconazole and paroxetine displayed inhibitory effects on the proliferation of T. cruzi (epimastigotes) and the uptake of putrescine by the parasite. They also interfered with the uptake of others aminoacids and the proliferation of infective T. brucei and L. infantum (promastigotes). Trypanothione synthetase was ruled out as molecular target for the anti-parasitic activity of these compounds. PMID:26891837

  20. Activity of Debio1452, a FabI Inhibitor with Potent Activity against Staphylococcus aureus and Coagulase-Negative Staphylococcus spp., Including Multidrug-Resistant Strains

    PubMed Central

    Rhomberg, Paul R.; Kaplan, Nachum; Jones, Ronald N.; Farrell, David J.

    2015-01-01

    Staphylococcus aureus and coagulase-negative staphylococci (CoNS) are responsible for a wide variety of human infections. The investigational antibacterial Debio1450 (previously AFN-1720), a prodrug of Debio1452 (previously AFN-1252), specifically targets staphylococci without significant activity against other Gram-positive or Gram-negative species. Debio1452 inhibits FabI, an enzyme critical to fatty acid biosynthesis in staphylococci. The activity of Debio1452 against CoNS, methicillin-susceptible S. aureus (MSSA), and methicillin-resistant S. aureus (MRSA), including significant clones, was determined. A globally diverse collection of 574 patient isolates from 35 countries was tested that included CoNS (6 species, 103 strains), MSSA (154 strains), MRSA (163 strains), and molecularly characterized strains (including spa-typed MRSA clones; 154 strains). The isolates were tested for susceptibility by CLSI broth microdilution methods against Debio1452 and 10 comparators. The susceptibility rates for the comparators were determined using CLSI and EUCAST breakpoint criteria. All S. aureus and CoNS strains were inhibited by Debio1452 concentrations of ≤0.12 and ≤0.5 μg/ml, respectively. The MIC50s for MSSA, MRSA, and molecularly characterized MRSA strains were 0.004 μg/ml, and the MIC90s ranged from 0.008 to 0.03 μg/ml. The MICs were higher for the CoNS isolates (MIC50/90, 0.015/0.12 μg/ml). Among S. aureus strains, resistance was common for erythromycin (61.6%), levofloxacin (49.0%), clindamycin (27.6%), tetracycline (15.7%), and trimethoprim-sulfamethoxazole (7.0%). Debio1452 demonstrated potent activity against MSSA, MRSA, and CoNS. Debio1452 showed significantly greater activity overall (MIC50, 0.004 μg/ml) than the other agents tested against these staphylococcal species, which included dominant MRSA clones and strains resistant to currently utilized antimicrobial agents. PMID:25691627