22 CFR 216.2 - Applicability of procedures.

Code of Federal Regulations, 2011 CFR

2011-04-01

... confined to small areas and carefully monitored; (iii) Analyses, studies, academic or research workshops... details of the specific activities conducted by the PVO; (xiv) Studies, projects or programs intended to...

40 CFR 52.73 - Approval of plans.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Strategies (Section III.B.5), Modeling and Projections (Section III.B.6), Contingency Plan (Section III.B.7...), Modeling and Projections (Section III.C.6), and Air Quality Conformity Procedures (Section III.C.10); and...

77 FR 13316 - FFP Project 91, LLC, Riverbank Hydro No. 23, LLC, Lock+ Hydro Friends Fund III; Notice Announcing...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-06

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project Nos. 14275-000, 14279-000, 14282-000] FFP Project 91, LLC, Riverbank Hydro No. 23, LLC, Lock+ Hydro Friends Fund III; Notice.... 2. Riverbank Hydro No. 23, LLC: Project No. 14279-000. 3. Lock+ Hydro Friends Fund III: Project No...

FOSPA Program Description. Parent-Child Programs: District 742 Community Education's Early Childhood Family Education Project [Revised].

ERIC Educational Resources Information Center

Hoodecheck, Jeanne; Kearns, Ellen

The Family Oriented Structured Preschool Activity (FOSPA) program, an Early Childhood/Family Education program for parents and their 4-year-old children, is described. FOSPA is a nationally validated Title III, Elementary and Secondary Education Act demonstration project in the St. Cloud Community Schools district of Minnesota. Based on research…

75 FR 63187 - Agency Information Collection Activities: Submission for OMB Review Comment Request: Supplemental...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-14

...: Heather Wiley, 202-357-3437. SUPPLEMENTARY INFORMATION: In compliance with 44 U.S.C. 3507, AoA has... projects funded by the Older Americans Act are being administered by grantees, in conformance with... Federal oversight of Title III Projects. AoA estimates the burden of this collection of information as...

Project Success for the SLD Child, Motor-Perception Activities.

ERIC Educational Resources Information Center

Wayne - Carroll Public Schools, Wayne, NE.

Presented is a curriculum guide for a perceptual motor program which was developed by Project Success (Nebraska) through a Title III grant for language learning disabled elementary level students in kindergarten through grade 3. The program is said to be arranged in a hierarchy of skills ranging from simple to complex and to be written so that the…

Pennsylvania Turnpike Commission's advanced traveler information system (ATIS) phase III project

DOT National Transportation Integrated Search

2006-02-14

In October 1998, the Pennsylvania Turnpike Commission (Commission) submitted a Partnership Agreement to the Federal Highway Administration (FHWA) for specific Intelligent Transportation Systems (ITS) activities, and to maximize the involvement of the...

Project Real World: Economic Living Skills for High School Students. Module III, Resource Management Skills--What Money Can't Buy.

ERIC Educational Resources Information Center

Federal/Provincial Consumer Education and Plain Language Task Force (Canada).

Project Real World, a self-contained, activity-based Canadian consumer science program, provides students with systematic instruction in economic living skills. It gives students in grades 10-12 an orientation to the economic realities and opportunities in society. The program helps students function effectively within the rapidly changing…

E-3A EMP Evaluation Program.

DTIC Science & Technology

1980-01-01

34OGRAh~g"NT. PROJECT, TASI( AREA & YRIC UIT NUMBERS EG&G, Inc. 9733 Coors Road NW 67I/7Z~i Albuqueroue,_NM_87114 _____________ 11. CONTROLLING OFFICE...Report) III. SUPPLEMENTARY NOTES III. KCy WORDS (Centingnpo r. everse wooe Ii noeew ayE ~Eeatly by’ b1euk nuabr) E- 3A Airborne Warning and Control ... CONTROL PROCEDURE ANALYSIS . 73 1 L -.... TABLE OF CONTENTS (Continued) Page SECTION V TEST ACTIVITIES .... .............. . 81 1. PRE-PULSE

III-V/Active-Silicon Integration for Low-Cost High-Performance Concentrator Photovoltaics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ringel, Steven

This FPACE project was motivated by the need to establish the foundational pathway to achieve concentrator solar cell efficiencies greater than 50%. At such an efficiency, DOE modeling projected that a III-V CPV module cost of $0.50/W or better could be achieved. Therefore, the goal of this project was to investigate, develop and advance a III-V/Si mulitjunction (MJ) CPV technology that can simultaneously address the primary cost barrier for III-V MJ solar cells while enabling nearly ideal MJ bandgap profiles that can yield efficiencies in excess of 50% under concentrated sunlight. The proposed methodology was based on use of ourmore » recently developed GaAsP metamorphic graded buffer as a pathway to integrate unique GaAsP and Ga-rich GaInP middle and top junctions having bandgaps that are adjustable between 1.45 – 1.65 eV and 1.9 – 2.1 eV, respectively, with an underlying, 1.1 eV active Si subcell/substrate. With this design, the Si can be an active component sub-cell due to the semi-transparent nature of the GaAsP buffer with respect to Si as well as a low-cost alternative substrate that is amenable to scaling with existing Si foundry infrastructure, providing a reduction in materials cost and a low cost path to manufacturing at scale. By backside bonding of a SiGe, a path to exceed 50% efficiency is possible. Throughout the course of this effort, an expansive range of new understanding was achieved that has stimulated worldwide efforts in III-V/Si PV R&D that spanned materials development, metamorphic device optimization, and complete III-V/Si monolithic integration. Highlights include the demonstration of the first ideal GaP/Si interfaces grown by industry-standard MOCVD processes, the first high performance metamorphic tunnel junctions designed for III-V/Si integration, record performance of specific metamorphic sub-cell designs, the first fully integrated GaInP/GaAsP/Si double (1.7 eV/1.1 eV) and triple (1.95 eV/1.5 eV/1.1 eV) junction solar cells, the first high performance GaAsP/Si double junction cell, the demonstration of a new method that allow for rapid, quantitative and non-destructive characterization of dislocations (ECCI-electron channeling contrast imaging), the first observation, explanation and solution of the now commonly reported lifetime degradation and recovery phenomena in III-V/Si MOCVD growth, the first demonstration of a high performance SiGe cell with a bandgap of 0.9 eV, amongst other highlights. The impact of the program on the international community has been significant. At the start of our FPACE1 project and for the immediate prior years, 1-2 conference papers/annually were presented at IEEE PVSC. Once FPACE1 commenced in 2011, related efforts sprouted across the US, Europe and Asia and by 2015 there were 26 papers presented on III-V/Si multijunctions in the 2015 PVSC, demonstrating the excitement that was stimulated by the results of this FPACE1 effort.« less

Enhanced Night Visibility Series, Volume XVI : Phase III, Characterization of Experimental Objects

DOT National Transportation Integrated Search

2005-12-01

The Enhanced Night Visibility (ENV) project is a series of experiments undertaken to investigate different visual enhancement systems (VES) for the nighttime driving task. The purpose of this characterization activity is to establish the photometric ...

Development of an improved system for contract time determination : phase III.

DOT National Transportation Integrated Search

2010-09-30

This study developed Daily Work Report (DWR) based prediction models to determine reasonable : production rates of controlling activities of highway projects. The study used available resources such as : DWR, soil data, AADT and other existing projec...

78 FR 72879 - Western Minnesota Municipal Power Agency; Lock+ Hydro Friends Fund III, LLC; Notice Announcing...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-04

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 14540-000; Project No. 14539-000] Western Minnesota Municipal Power Agency; Lock+ Hydro Friends Fund III, LLC; Notice.... 14540-000 2. Lock+ Hydro Friends Fund III, LLC Project No. 14539-000 Dated: November 26, 2013. Nathaniel...

A Guide to Establishing and Directing a Family Oriented Structured Preschool Activity.

ERIC Educational Resources Information Center

Maethner, Judith A.

This is the teacher's manual of the Family Oriented Structured Preschool Activity, a Title III Elementary and Secondary Education Act Developer/Demonstration Project in Saint Cloud, Minnesota. The program attempts to mold the expertise of the parent with the expertise of the professional educator in order to enhance the child's development. It is…

Urban Environmental Education Project, Curriculum Module III: Urban Transportation - Where Are We Going?

ERIC Educational Resources Information Center

Bell, Ellen

Included in this module are five activities dealing with modes of transportation in the urban environment. The activities include: (1) a discussion of transportation considerations in urban areas; (2) discussion of bikeways and their desirability in the urban environment; (3) the bikeway and the environment; (4) designing a bikeway; and (5)…

7 CFR 3407.6 - Categorical exclusions.

Code of Federal Regulations, 2010 CFR

2010-01-01

..., and transfer or reprogramming of funds; (iii) Inventories, research activities and studies, such as... Agriculture Regulations of the Department of Agriculture (Continued) COOPERATIVE STATE RESEARCH, EDUCATION...: (i) The following categories of research programs or projects of limited size and magnitude or with...

An Action Resarch Proposal: Identifying and Addressing Problems Related to RACC's Writing Laboratory. Title III Curriculum Enrichment Activity: Faculty Development Project. Final Report.

ERIC Educational Resources Information Center

Horner, Annette; Jacobson, Karen H.

An action research project was undertaken to understand how the Writing Laboratory at Reading Area Community College (RACC) defines and accomplishes its work, what faculty and students expect of the lab, and how they make use of it. The investigation sought to foster discussion and reflection on the appropriate role and staffing of a college…

76 FR 73615 - FFP Project 91 LLC; Riverbank Hydro No. 23 LLC; Lock Hydro Friends Fund III; Notice of Competing...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-29

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project Nos. 14275-000; 14279-000; 14282-000] FFP Project 91 LLC; Riverbank Hydro No. 23 LLC; Lock Hydro Friends Fund III; Notice of... LLC (Riverbank), and Lock Hydro Friends Fund III (Lock Hydro), filed preliminary permit applications...

Phase III of Early Restoration | NOAA Gulf Spill Restoration

Science.gov Websites

information about this phase of Early Restoration, including fact sheets on each project. The final Phase III 44 projects are documented in a final Record of Decision. Information about Phase III of Early Archive Home Phase III of Early Restoration Phase III of Early Restoration Beach habitat would be restored

LINKING WATERFOWL WITH CONTAMINANT SPECIATION IN RIPARIAN SOILS

EPA Science Inventory

This report summarizes the results of Mine Waste Technology Program (MWTP) Activity III, Project 38, Linking Waterfowl with Contaminant Speciation in Riparian Soils, implemented and funded by the U.S. Environmental Protection Agency (EPA) and jointly administered by EPA and the U...

Integrated Passive Biological Treatment System/ Mine Waste Technology Program Report #16

EPA Science Inventory

This report summarizes the results of the Mine Waste Technology Program (MWTP) Activity III, Project 16, Integrated, Passive Biological Treatment System, funded by the United States Environmental Protection Agency (EPA) and jointly administered by EPA and the United States Depar...

Mine Waste Technology Program Electrochemical Tailings Cover

EPA Science Inventory

This report summarizes the results of Mine Waste Technology Program (MWTP) Activity III, Project 40, Electrochemical Tailings Cover, funded by the U.S. Environmental Protection Agency (EPA) and jointly administered by EPA and the U.S. Department of Energy (DOE). MSE Technology A...

Project ACE Activity Sets. Book III: Grades 8 through 12.

ERIC Educational Resources Information Center

Eden City Schools, NC.

Eleven activity sets for students in grades 8 through 12 are designed to supplement courses in citizenship and U.S. history and government. "The Civil War That Could Have Been" creates a hypothetical situation which requires the participant to analyze the causes of the Civil War. In "History on TV -- Enemy or Ally of the Social Studies Program,"…

Mine Waste Technology Program. Passive Treatment for Reducing Metal Loading

EPA Science Inventory

This report summarizes the results of Mine Waste Technology Program (MWTP) Activity III, Project 48, Passive Treatment Technology Evaluation for Reducing Metal Loading, funded by the U.S. Environmental Protection Agency (EPA) and jointly administered by EPA and the U.S. Departmen...

A survey and photographic inventory of metal truss bridges in Virginia, 1865-1932 : III : the Culpeper construction district.

DOT National Transportation Integrated Search

1975-01-01

Prior to 1932, road maintenance and construction in Virginia were largely the responsibility of the individual county governments. Bridge construction projects formed a natural part of these activities. Local responsibility resulted in a rich variety...

24 CFR 51.106 - Implementation.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Implementation. 51.106 Section 51.106 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development... urbanized areas and on development activity. (iii) Impact on HUD-assisted projects currently in processing...

24 CFR 51.106 - Implementation.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 24 Housing and Urban Development 1 2014-04-01 2014-04-01 false Implementation. 51.106 Section 51.106 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development... urbanized areas and on development activity. (iii) Impact on HUD-assisted projects currently in processing...

24 CFR 51.106 - Implementation.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 24 Housing and Urban Development 1 2013-04-01 2013-04-01 false Implementation. 51.106 Section 51.106 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development... urbanized areas and on development activity. (iii) Impact on HUD-assisted projects currently in processing...

7 CFR 3407.6 - Categorical exclusions.

Code of Federal Regulations, 2012 CFR

2012-01-01

...; (iii) Inventories, research activities and studies, such as resource inventories and routine data... impacts on the quality of the human environment: (i) The following categories of research programs or projects of limited size and magnitude or with only short-term effects on the environment: (A) Research...

7 CFR 3407.6 - Categorical exclusions.

Code of Federal Regulations, 2014 CFR

2014-01-01

...; (iii) Inventories, research activities and studies, such as resource inventories and routine data... impacts on the quality of the human environment: (i) The following categories of research programs or projects of limited size and magnitude or with only short-term effects on the environment: (A) Research...

7 CFR 3407.6 - Categorical exclusions.

Code of Federal Regulations, 2013 CFR

2013-01-01

...; (iii) Inventories, research activities and studies, such as resource inventories and routine data... impacts on the quality of the human environment: (i) The following categories of research programs or projects of limited size and magnitude or with only short-term effects on the environment: (A) Research...

47 CFR 54.705 - Committees of the Administrator's Board of Directors.

Code of Federal Regulations, 2010 CFR

2010-10-01

... decisions concerning: (i) How the Administrator projects demand for the schools and libraries support... libraries support mechanism; (iii) Administration of the application process, including activities to ensure... be applied to services purchased by eligible schools and libraries; (x) Performance of audits of...

76 FR 79675 - Pomperaug Hydro Project Andrew Peklo III; Notice of Site Visit and Technical Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-22

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 12790-001] Pomperaug Hydro Project Andrew Peklo III; Notice of Site Visit and Technical Meeting On January 18, 2012, Office of Energy Projects staff will hold a site visit and technical meeting for the proposed Pomperaug Hydro Project (FERC...

Kindling alters entorhinal cortex-hippocampal interaction by increased efficacy of presynaptic GABA(B) autoreceptors in layer III of the entorhinal cortex.

PubMed

Gloveli, Tengis; Behr, Joachim; Dugladze, Tamar; Kokaia, Zaal; Kokaia, Merab; Heinemann, Uwe

2003-08-01

We studied the effect of kindling, a model of temporal lobe epilepsy, on the frequency-dependent information transfer from the entorhinal cortex to the hippocampus in vitro. In control rats repetitive synaptic activation of layer III projection cells resulted in a frequency dependent depression of the synaptic transfer of action potentials to the hippocampus. One-to-two-days after kindling this effect was strongly reduced. Although no substantial change in synaptic inhibition upon single electrical stimulation was detected in kindled rats, there was a significant depression in the prolonged inhibition following high frequency stimulation. In kindled animals, paired-pulse depression (PPD) of stimulus-evoked IPSCs in layer III neurons was significantly stronger than in control rats. The increase of PPD is most likely caused by an increased presynaptic GABA(B) receptor-mediated autoinhibition. In kindled animals activation of presynaptic GABA(B) receptors by baclofen (10 microM) suppressed monosynaptic IPSCs significantly more than in control rats. In contrast, activation of postsynaptic GABA(B) receptors by baclofen was accompanied by comparable changes of the membrane conductance in both animal groups. Thus, in kindled animals activation of the layer III-CA1 pathway is facilitated by an increased GABA(B) receptor-mediated autoinhibition leading to an enhanced activation of the monosynaptic EC-CA1 pathway.

Community governance of the Kahnawake Schools Diabetes Prevention Project, Kahnawake Territory, Mohawk Nation, Canada.

PubMed

Cargo, Margaret; Lévesque, Lucie; Macaulay, Ann C; McComber, Alex; Desrosiers, Serge; Delormier, Treena; Potvin, Louise

2003-09-01

Health promotion emphasizes the importance of community ownership in the governance of community-based programmes, yet little research has been conducted in this area. This study examined perceptions of community ownership among project partners taking responsibility for decision-making related to the Kahnawake Schools Diabetes Prevention Project (KSDPP). Project partners were surveyed cross-sectionally at 18 months (T1) and 60 months (T2) into the project. The perceived influence of each project partner was assessed at T1 and T2 for three domains: (i) KSDPP activities; (ii) KSDPP operations; and (iii) Community Advisory Board (CAB) activities. Project staff were perceived to have the greatest influence on KSDPP activities, KSDPP operations and CAB activities at both T1 and T2. High mean scores of perceived influence for CAB members and community researchers, however, suggests that project decision-making was a shared responsibility among multiple community partners. Although academic researcher influence was consistently low, they were satisfied with their level of influence. This was unlike community affiliates, who were less satisfied with their lower level of influence. In keeping with Kanien'kehaka (Mohawk) culture, the findings suggest a participatory democracy or shared decision-making as the primary mode of governance of KSDPP.

Chattanooga SmartBus Project : phase III evaluation report

DOT National Transportation Integrated Search

2009-12-01

This report presents the results of Phase III of the national evaluation of the Chattanooga Area Regional Transportation Authoritys (CARTA) SmartBus Project. The SmartBus Project is a comprehensive transit ITS program for the city of Chattanooga, ...

Women Aboard Navy Ships: A Comprehensive Health and Readiness Research Project. Volume 2

DTIC Science & Technology

1996-12-31

strategies in women with and without dysmenorrhea. Health Care for Women Int 1995; 16:167-178. 13. Greene JW. Exercise - induced menstrual irregularities...get enough exercise , lack of recreational activities, the people with whom living space is shared, nutrition or the unavailability of desired foods...enough exercise 13.3 17.2 14.0 11.0 13.2 17.0 11.8 18.9 19iiiiiiiii 151ii!~iii t5iiiiiiiiii4ii $0.0~ iii aboard ship M aintaining •i~~ii~~i

30 CFR 250.201 - What plans and information must I submit before I conduct any activities on my lease or unit?

Code of Federal Regulations, 2010 CFR

2010-07-01

... production from development projects in water depths greater than 1,312 feet (400 meters). (6) EP, DPP, or... greater than 500 feet (152 meters); (ii) It will involve the use of explosives; (iii) The Regional...

Elevating the Importance of Teaching. National Project III. Final Report.

ERIC Educational Resources Information Center

Owens, Richard E.

An in-depth study was conducted of instructional improvement activities at Kansas State University, including a student evaluation instrument of teacher performance, called Instructional Development and Effectiveness Assessment (IDEA). Faculty reactions to the total evaluation system, the use of results for multiple purposes, and the current…

Project Basic Instructional Guide: Volume III, Citizenship.

ERIC Educational Resources Information Center

Maryland State Dept. of Education, Baltimore.

A series of elementary and secondary school learning activities which correlate to citizenship education goals of the Maryland State Board of Education are presented. The five goals are to understand individual and group responsibilities in a democracy, know the functions of law and support a system of justice, value individual, societal, and…

National Project III, Elevating the Importance of Teaching. Fund Associate's Final Report.

ERIC Educational Resources Information Center

Seibert, Warren F.

Purdue University's participation as a fund associate in National Project III (NP III) for elevating the importance of teaching has its origins in a flexible and diagnostic instructional evaluation system called "CAFETERIA." CAFETERIA services include test development, scoring, and analysis; social surveys on topics of importance in…

76 FR 33589 - Standards Improvement Project-Phase III

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-08

... rule: I. Background A. Introduction B. Regulatory History II. Legal Considerations III. Summary and... without diminishing worker protections. B. Regulatory History The Standards Improvement Project (SIP...

[New Retrieval Algorithms for Geophysical Products from GLI and MODIS Data

NASA Technical Reports Server (NTRS)

Dodge, James C.; Simpson, James J.

2004-01-01

Below is the 1st year progress report for NAG5-13435 "New Retrieval Algorithms for Geophysical Products from GLI and MODIS Data". Activity on this project has been coordinated with our NASA DB project NAG5-9604. For your convenience, this report has six sections and an Appendix. Sections I - III discuss specific activities undertaken during the past year to analyze/use MODIS data. Section IV formally states our intention to no longer pursue any research using JAXA's (formerly NASDA's) GLI instrument which catastrophically failed very early after launch (also see the Appendix). Section V provides some indications of directions for second year activities based on our January 2004 telephone discussions and email exchanges. A brief summary is given in Section VI.

77 FR 2968 - Pomperaug Hydro Project, Andrew Peklo III; Notice Establishing Deadline for Comments and Reply...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-20

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 12790-001] Pomperaug Hydro Project, Andrew Peklo III; Notice Establishing Deadline for Comments and Reply Comments On December 15, 2011, the Commission issued notice that Office of Energy Projects staff will hold a site visit and technical meeting on January 18, 2012. The...

Teaching is for Kids. 1972 Edition. [A Documentary of Title III, ESEA Projects in Maine.

ERIC Educational Resources Information Center

Maine State Dept. of Education, Augusta.

In this documentary of Title III projects funded under the Elementary and Secondary Education Act, a 2-page descriptive narrative of each of 10 funded projects in Maine is given. Each project is classified by subject matter and is listed under 1 of the following headings: (1) Professional Improvement, (2) Help for the Educationally Disadvantaged,…

34 CFR 636.21 - What selection criteria does the Secretary use to evaluate an application?

Code of Federal Regulations, 2011 CFR

2011-07-01

...) Agencies of local government. (ii) Public and private elementary and secondary schools. (iii) Business... implementation strategy for each key project component activity is— (i) Comprehensive; (ii) Based on a sound... operation; (5) Describe a time-line chart that relates key evaluation processes and benchmarks to other...

34 CFR 636.21 - What selection criteria does the Secretary use to evaluate an application?

Code of Federal Regulations, 2014 CFR

2014-07-01

...) Agencies of local government. (ii) Public and private elementary and secondary schools. (iii) Business... implementation strategy for each key project component activity is— (i) Comprehensive; (ii) Based on a sound... operation; (5) Describe a time-line chart that relates key evaluation processes and benchmarks to other...

34 CFR 636.21 - What selection criteria does the Secretary use to evaluate an application?

Code of Federal Regulations, 2013 CFR

2013-07-01

...) Agencies of local government. (ii) Public and private elementary and secondary schools. (iii) Business... implementation strategy for each key project component activity is— (i) Comprehensive; (ii) Based on a sound... operation; (5) Describe a time-line chart that relates key evaluation processes and benchmarks to other...

34 CFR 636.21 - What selection criteria does the Secretary use to evaluate an application?

Code of Federal Regulations, 2012 CFR

2012-07-01

...) Agencies of local government. (ii) Public and private elementary and secondary schools. (iii) Business... implementation strategy for each key project component activity is— (i) Comprehensive; (ii) Based on a sound... operation; (5) Describe a time-line chart that relates key evaluation processes and benchmarks to other...

The Mushroom Place. Part III.

ERIC Educational Resources Information Center

Schlichter, Carol

1978-01-01

The final installment of a series of articles on the "Mushroom Place" learning center program, which involves creative thinking activities for young, gifted students, describes "Doing It the Hard Way," a performance task which involves the actual construction of objects from a selected set of materials in the absence of the usual project tools.…

Problem-Based Learning in an Online Course of Health Education

ERIC Educational Resources Information Center

Chagas, Isabel; Faria, Claudia; Mourato, Dulce; Pereira, Goncalo; Santos, Afonso

2012-01-01

The objectives of this project were to: i) describe the experience of implementing Problem-Based Learning in an online course over three consecutive academic years, ii) analyse the learning environment generated, iii) discuss impacts on students' active participation, based on the analysis of their interactions. The participants were 30 students,…

Mine Waste Technology Program. In Situ Source Control Of Acid Generation Using Sulfate-Reducing Bacteria

EPA Science Inventory

This report summarizes the results of the Mine Waste Technology Program (MWTP) Activity III, Project 3, In Situ Source Control of Acid Generation Using Sulfate-Reducing Bacteria, funded by the U.S. Environmental Protection Agency (EPA) and jointly administered by EPA and the U.S....

77 FR 20621 - Pomperaug Hydro Project; Andrew Peklo III; Notice Extending Deadline for Comments

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-05

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 12790-001] Pomperaug Hydro Project; Andrew Peklo III; Notice Extending Deadline for Comments On January 18, 2012, Office of Energy... the Commission's January 12, 2012, notice, the deadline for filing comments is extended to April 13...

76 FR 81927 - Shiloh III Wind Project, LLC; Notice of Petition for Declaratory Order

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-29

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. EL12-15-000] Shiloh III Wind... section 201 of the Federal Power Act, 16 U.S.C. 824, Shiloh III Wind Project, LLC filed a Petition for... over the Owner-Lessor in a structure lease financing transaction for wind powered generation and...

Pacesetters 1973 Evaluation: Idaho Emphasis, Title III ESEA.

ERIC Educational Resources Information Center

Brown, Charles A., Comp.

Twenty-two exemplary and innovative Projects to Advance Creativity in Education (PACE), funded by Title III of the Elementary and Secondary Act of 1965, which serve the role of demonstrating the feasibility of innovations in a local context, are summarized in this evaluation booklet of Title III ESEA Idaho Projects for the 1970 through 1973 school…

A Messaging Infrastructure for WLCG

NASA Astrophysics Data System (ADS)

Casey, James; Cons, Lionel; Lapka, Wojciech; Paladin, Massimo; Skaburskas, Konstantin

2011-12-01

During the EGEE-III project operational tools such as SAM, Nagios, Gridview, the regional Dashboard and GGUS moved to a communication architecture based on ActiveMQ, an open-source enterprise messaging solution. LHC experiments, in particular ATLAS, developed prototypes of systems using the same messaging infrastructure, validating the system for their use-cases. In this paper we describe the WLCG messaging use cases and outline an improved messaging architecture based on the experience gained during the EGEE-III period. We show how this provides a solid basis for many applications, including the grid middleware, to improve their resilience and reliability.

Laterally injected light-emitting diode and laser diode

DOEpatents

Miller, Mary A.; Crawford, Mary H.; Allerman, Andrew A.

2015-06-16

A p-type superlattice is used to laterally inject holes into an III-nitride multiple quantum well active layer, enabling efficient light extraction from the active area. Laterally-injected light-emitting diodes and laser diodes can enable brighter, more efficient devices that impact a wide range of wavelengths and applications. For UV wavelengths, applications include fluorescence-based biological sensing, epoxy curing, and water purification. For visible devices, applications include solid state lighting and projection systems.

Alternatives: A Survey of Title III, ESEA, Projects in New Mexico.

ERIC Educational Resources Information Center

New Mexico State Dept. of Education, Santa Fe.

This survey provides a moderately detailed description of each of 13 projects funded under 1965 Elementary Secondary Education Act Title III. Freedom High School is an alternative school. The Resource Room for Visually Impaired Children was established in 1972. The Remediating Motor Dysfunction project helps elementary school students to enter a…

SPEEDIER Project. Third Annual Report, 1969-70.

ERIC Educational Resources Information Center

Curriculum Study Research and Development Council of South Central Pennsylvania, Palmyra.

This project was funded under ESEA Title III and four subcontracts with Research for Better Schools. The Title III aspect of the project focused on curriculum change in the fields of language arts, social sciences, and teacher training. Complete reports on each of the following have been included: 1) the Social Studies Pilot Programs as described…

Connecticut E.S.E.A. Title III Catalog.

ERIC Educational Resources Information Center

Area Cooperative Educational Services, New Haven, CT. Educational Resources Center.

Title III projects conducted by local education agencies in Connecticut are listed alphabetically by agency and described. Each entry gives project title, amount and term of funding, target population, major objectives, evaluation design, findings to date, and dissemination plan. The agency name and address and the project director for each of the…

7 CFR Exhibit A to Subpart B of... - Grant Agreement-Growth Management and Housing Planning for Approved Designated Energy Impacted Areas

Code of Federal Regulations, 2011 CFR

2011-01-01

... met; (iii) Problems, delays, or adverse conditions which will materially affect attainment of planned... process which will improve local conditions and alleviate problems associated with increased coal or... Grantee programs, projects, related activities, and problems. (b) The Grantee shall inform the Grantor as...

50 CFR 18.27 - Regulations governing small takes of marine mammals incidental to specified activities.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Protection Act may be allowed only if the Director of the Fish and Wildlife Service (1) finds, based on the... Project (Clearance No. 1018-0070), Washington, DC 20503. (c) Definitions. In addition to definitions... the specific geographical region where it will occur; (iii) Based upon the best available scientific...

Title III Project in Outdoor and Conservation Education; School Districts, Town of North Hempstead. Project Summary Report.

ERIC Educational Resources Information Center

Schmierer, Hy

The document contains Part II, Narrative Report for End of Budget Period, and Part III, End of Year Evaluation Report, for the school districts of North Hempstead, New York. During the period from September of 1968 to September of 1969, under funds from Title III of the Elementary and Secondary Education Act, the North Hempstead districts began…

An Evaluation of ESEA Title III Projects, Fiscal Year 1972. Interim Report.

ERIC Educational Resources Information Center

Wilson, Jerusa; And Others

This report contains descriptions and progress of five projects in the District of Columbia partially or wholly funded by ESEA Title III: (1) The Columbia Road Preschool Pilot Project, a second-year experimental effort designed to serve as a model school providing an experimental setting for early childhood educational programs; (2) The Montessori…

Some Effects of Schooling: A Three Year Follow-Up of a Title III Project.

ERIC Educational Resources Information Center

Barclay, James R.; And Others

This paper presents an evaluation of a 3-year Title III project carried out in the Vigo County School Cooperation, Terre Haute, Indiana. The project involved the evaluation of three differing instructional methodologies utilized in three elementary schools which also differed in the socioeconomic background of the students. The Dixie Bee school,…

The Compact Environmental Anomaly Sensor (CEASE) III

NASA Astrophysics Data System (ADS)

Roddy, P.; Hilmer, R. V.; Ballenthin, J.; Lindstrom, C. D.; Barton, D. A.; Ignazio, J. M.; Coombs, J. M.; Johnston, W. R.; Wheelock, A. T.; Quigley, S.

2016-12-01

The Air Force Research Laboratory's Energetic Charged Particle (ECP) sensor project is a comprehensive effort to measure the charged particle environment that causes satellite anomalies. The project includes the Compact Environmental Anomaly Sensor (CEASE) III, building on the flight heritage of prior CEASE designs. CEASE III consists of multiple sensor modules. High energy particles are observed using independent unique silicon detector stacks. In addition CEASE III includes an electrostatic analyzer (ESA) assembly which uses charge multiplication for particle detection. The sensors cover a wide range of proton and electron energies that contribute to satellite anomalies.

Report on Region III's asbestos hotline. Technical report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lubick, L.

1989-01-01

The report is part of the National Network for Environmental Management Studies under the auspices of the Office of Cooperative Environmental Management of the U.S. Environmental Protection Agency. The research project studies the effectiveness of an asbestos hotline that was created by Reg. III in June, 1989 through the cooperative efforts of the Air Enforcement Branch and Toxics and Pesticides Branch in Region III for use in the Annapolis, MD area. The hotline enables public officials to act upon confidential tips provided by citizens who are aware of potential asbestos violations. The major thrust of the NNEMS project focuses onmore » outreach activities-making the public aware of asbestos problems and of the Annapolis hotline as a tool to address their concerns. Diverse groups were targeted through press, radio, Congress and the public school system explaining the role citizens play in the control of asbestos. Subsequent citizen use of the hotline cited violations in public offices and manufacturing buildings, but did not produce reports of violations in school facilities. Apparently, school fliers failed to reach their target audience. Preliminary analysis indicates that the most effective method to publicize the hotline is through public service announcements on radio and in newspapers.« less

Morphology and mechanism of the very large dunes in the tidal reach of the Yangtze River, China

NASA Astrophysics Data System (ADS)

Shuwei, Zheng; Heqin, Cheng; Shuaihu, Wu; Shengyu, Shi; Wei, Xu; Quanping, Zhou; Yuehua, Jiang

2017-05-01

High-resolution multibeam data was used to interpret the surface morphology of very large dunes (VLDs) in the tidal reach of the Yangtze River, China. These VLDs can be divided into three categories according to their surface morphological characteristics. (1) VLDs-I: those with a smooth surface and cross-section; (2) VLDs-II: those accompanied by secondary dunes; (3) VLDs-III: those accompanied by secondary dunes and numerous elliptical pits. Parameters and spatial distribution of VLDs, and bed surface sediment were analyzed in the laboratory. Overall, channel morphology is an important factor affecting the development of VLDs, and channels with narrow and straight and certain water surface slope are facilitating the development of VLDs by constraining stream power. Meanwhile, distribution density of VLDs depicts a decreasing trend from Chizhou towards the estuary, are probably influenced by channel morphology and width. Associated pits in VLDs-III change the 3D dune morphology by distributing in secondary dunes as beads. The Three Gorges Dam project (TGP) leads to the bed surface sediment activity frequently and leads to the riverbed surface sediment coarsens, which promotes the further development of dunes. Moreover, other human activities, such as river regulation project, sand mining and Deep Water Channel Regulation Project have changed the regional river boundary conditions and hydrodynamic conditions are influential on the development of VLDs.

Monterey-Salinas Transit ITS Augmentation Project : Phase III Evaluation Report

DOT National Transportation Integrated Search

2009-12-01

The purpose of this document is to present the findings from Phase II and Phase III of the Evaluation of the Intelligent Transportation Systems (ITS) Augmentation Project that was implemented at the Monterey-Salinas Transit (MST) in Monterey, Califor...

15 CFR Appendix B to Subpart R of... - Minor Projects for Purposes of § 922.193(a)(2)(iii)

Code of Federal Regulations, 2012 CFR

2012-01-01

....193(a)(2)(iii) B Appendix B to Subpart R of Part 922 Commerce and Foreign Trade Regulations Relating... Thunder Bay National Marine Sanctuary and Underwater Preserve Pt. 922, Subpt. R, App. B Appendix B to Subpart R of Part 922—Minor Projects for Purposes of § 922.193(a)(2)(iii) Pursuant to Michigan State...

15 CFR Appendix B to Subpart R of... - Minor Projects for Purposes of § 922.193(a)(2)(iii)

Code of Federal Regulations, 2014 CFR

2014-01-01

....193(a)(2)(iii) B Appendix B to Subpart R of Part 922 Commerce and Foreign Trade Regulations Relating... Thunder Bay National Marine Sanctuary and Underwater Preserve Pt. 922, Subpt. R, App. B Appendix B to Subpart R of Part 922—Minor Projects for Purposes of § 922.193(a)(2)(iii) Pursuant to Michigan State...

15 CFR Appendix B to Subpart R of... - Minor Projects for Purposes of § 922.193(a)(2)(iii)

Code of Federal Regulations, 2013 CFR

2013-01-01

....193(a)(2)(iii) B Appendix B to Subpart R of Part 922 Commerce and Foreign Trade Regulations Relating... Thunder Bay National Marine Sanctuary and Underwater Preserve Pt. 922, Subpt. R, App. B Appendix B to Subpart R of Part 922—Minor Projects for Purposes of § 922.193(a)(2)(iii) Pursuant to Michigan State...

Assimilation thru Cultural Understanding. ESEA III-Project I. Operation Assimilation through Cultural Understanding.

ERIC Educational Resources Information Center

Pennsylvania State Dept. of Public Instruction, Harrisburg. Bureau of General and Academic Education.

Presented is a project proposal for improving the assimilation of Puerto Rican and foreign born students in Hoboken, New Jersey. The project, to be funded by the Elementary and Secondary Education Act, Title III, intends to aid acculturation by giving school staffs an "in-depth experience" in Puerto Rico. It is felt that this field trip…

76 FR 17408 - Combined Notice of Filings #1

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-29

... WDT SERV AG PHOTON SOLAR DOMINGUEZ PV 1 PROJECT to be effective 5/18/2011. Filed Date: 03/18/2011... Company submits tariff filing per 35.13(a)(2)(iii: SGIA WDT SERV AG PHOTON SOLAR MID COUNTIES PV 5 PROJECT...)(2)(iii: SGIA WDT SERV AG PHOTON SOLAR INDUSTRY PV 1 PROJECT to be effective 5/18/2011. Filed Date...

Learning Styles of the Special Needs Student (K-6). Instructor's Manual. Project: Least Restrictive Environment. MCC Inservice Training for Regular Classroom Teachers. Year III, 1980-1981.

ERIC Educational Resources Information Center

Newman, Elizabeth

The instructor's manual considers the inservice training topic of special needs students' learning styles and their implications for regular class teachers. Activities are described to help participants understand modality learning and informal tests to determine modality strengths. Teaching strategies for auditory and visual weaknesses are…

The Healy clean coal project: An overview

DOE Office of Scientific and Technical Information (OSTI.GOV)

Olson, J.B.; McCrohan, D.V.

1997-12-31

The Healy Clean Coal Project, selected by the US Department of Energy under Round III of the Clean Coal Technology Program is currently in construction. The project is owned and financed by the Alaska Industrial Development and Export Authority (AIDEA), and is cofunded by the US Department of Energy. Construction is scheduled to be completed in August of 1997, with startup activity concluding in December of 1997. Demonstration, testing and reporting of the results will take place in 1998, followed by commercial operation of the facility. The emission levels of NOx, SO{sub 2} and particulates from this 50 megawatt plantmore » are expected to be significantly lower than current standards. The project status, its participants, a description of the technology to be demonstrated, and the operational and performance goals of this project are presented.« less

An EGFR wild type-EGFRvIII-HB-EGF feed forward loop regulates the activation of EGFRvIII

PubMed Central

Li, Li; Chakraborty, Sharmistha; Yang, Chin-Rang; Hatanpaa, Kimmo J.; Cipher, Daisha J.; Puliyappadamba, Vineshkumar Thidil; Rehman, Alizeh; Jiwani, Ameena J.; Mickey, Bruce; Madden, Christopher; Raisanen, Jack; Burma, Sandeep; Saha, Debabrata; Wang, Zhixiang; Pingle, Sandeep C.; Kesari, Santosh; Boothman, David A.; Habib, Amyn A.

2014-01-01

EGFRvIII is a key oncogene in glioblastoma (GBM). EGFRvIII results from an in frame deletion in the extracellular domain of EGFR, does not bind ligand, and is thought to be constitutively active. While EGFRvIII dimerization is known to activate EGFRvIII, the factors that drive EGFRvIII dimerization and activation are not well understood. Here we present a new model of EGFRvIII activation and propose that oncogenic activation of EGFRvIII in glioma cells is driven by co-expressed activated EGFR wild type (EGFRwt). Increasing EGFRwt leads to a striking increase in EGFRvIII tyrosine phosphorylation and activation while silencing EGFRwt inhibits EGFRvIII activation. Both the dimerization arm and the kinase activity of EGFRwt are required for EGFRvIII activation. EGFRwt activates EGFRvIII by facilitating EGFRvIII dimerization. We have previously identified HB-EGF, a ligand for EGFRwt, as a gene induced specifically by EGFRvIII. In this study we show that HB-EGF, is induced by EGFRvIII only when EGFRwt is present. Remarkably, altering HB-EGF recapitulates the effect of EGFRwt on EGFRvIII activation. Thus, increasing HB-EGF leads to a striking increase in EGFRvIII tyrosine phosphorylation while silencing HB-EGF attenuates EGFRvIII phosphorylation, suggesting that an EGFRvIII-HB-EGF-EGFRwt feed forward loop regulates EGFRvIII activation. Silencing EGFRwt or HB-EGF leads to a striking inhibition of EGFRvIII induced tumorigenicity, while increasing EGFRwt or HB-EGF levels resulted in accelerated EGFRvIII mediated oncogenicity in an orthotopic mouse model. Furthermore, we demonstrate the existence of this loop in human GBM. Thus, our data demonstrate that oncogenic activation of EGFRvIII in GBM is likely maintained by a continuous EGFRwt-EGFRvIII-HBEGF loop, potentially an attractive target for therapeutic intervention. PMID:24077285

Papers arising from IAEA Coordinated Research Project "Utilization of ion accelerators for studying and modelling of radiation induced defects in semiconductors and insulators" (F11016)

NASA Astrophysics Data System (ADS)

Vittone, Ettore; Breese, Mark; Simon, Aliz

2016-04-01

Within the International Atomic Energy Agency (IAEA) Department of Nuclear Sciences and Applications, activities are carried out to assist and advise IAEA Member States in assessing their needs for capacity building, research and development in nuclear sciences. Support is also provided to Member States' activities geared towards deriving benefits in fields such as (i) advanced materials for nuclear applications, (ii) application of accelerators and associated instrumentation, and (iii) nuclear, atomic and molecular data. One of the means that the IAEA uses to deliver its programme is Coordinated Research Projects (CRPs) which are very effective in stimulating international research and scientific interaction among the Member States.

Interlaminar and lateral excitatory amino acid connections in the striate cortex of monkey.

PubMed

Kisvarday, Z F; Cowey, A; Smith, A D; Somogyi, P

1989-02-01

The intrinsic excitatory amino acid pathways within the striate cortex of monkeys were studied by autoradiographic detection of retrogradely labeled somata following microinjections of D-3H-aspartate (D-3H-Asp) into different layers. The labeled amino acid was selectively accumulated by subpopulations of neurons and, to a small extent, by glial cells, the latter mainly in the supragranular layers. Immunocytochemical detection of neurons containing GABA showed that, apart from a few cells exclusively in layer I, GABAergic neurons do not accumulate D-3H-Asp. Several lines of evidence suggest that D-3H-Asp uptake occurred only at nerve terminals; thus, the pattern of perikaryal labeling allowed the delineation of interlaminar and lateral projections. Neurons in layer I probably project laterally, and layer I receives wide-ranging projections from layer IVB and layer V from cells up to 1300 microns laterally. Some neurons in layer II send a focused projection to lower layer VI. Some neurons in layers II/III project up to 1 mm laterally within their own layer, but relatively few neurons can be labeled in these projections. Similarly, in layers II/III few neurons can be retrogradely labeled from layers V and upper VI, and this projection is organized such that cells closer to the pia project deeper in layer V/VI. The connections of layer IVA could not be revealed separately because of the difficulty of confining injections to this thin sublamina. Neurons in layer IVB project up to 1300 microns within IVB itself. A small number of cells from IVB also project to layers III, IVC-alpha, V, and VI with much more restricted lateral spread. Neurons in upper IVC-alpha send axons to layer IVB with at least 600-800 microns lateral spread. Neurons in lower IVC-alpha/upper IVC-beta project to layer III with at least 300-500 microns lateral spread. The bottom 50-80 microns of layer IVC-beta contains neurons with a very focused projection, apparently exclusively to the layer III/IVA border region. Both layers IVC alpha and beta have rich connections within themselves, the beta sublayer having more restricted lateral connections. Some neurons in layer IVC-beta give a laterally restricted small input to layers IVC-alpha and IVB. Both IVC-alpha and -beta project to layers V and VI, and these projections are spread at least 400 microns laterally. Neurons in layer V project to all layers, but the projection to layers I-III and within layer V itself spread much further laterally than the projections to layers IV and VI.(ABSTRACT TRUNCATED AT 400 WORDS)

Structural Acoustic Characteristics of Aircraft and Active Control of Interior Noise

NASA Technical Reports Server (NTRS)

Fuller, C. R.

1998-01-01

The reduction of aircraft cabin sound levels to acceptable values still remains a topic of much research. The use of conventional passive approaches has been extensively studied and implemented. However performance limits of these techniques have been reached. In this project, new techniques for understanding the structural acoustic behavior of aircraft fuselages and the use of this knowledge in developing advanced new control approaches are investigated. A central feature of the project is the Aircraft Fuselage Test Facility at Va Tech which is based around a full scale Cessna Citation III fuselage. The work is divided into two main parts; the first part investigates the use of an inverse technique for identifying dominant fuselage vibrations. The second part studies the development and implementation of active and active-passive techniques for controlling aircraft interior noise.

1967-1968 Project Reports by Faculty Members of San Joaquin Delta College: A Project under Title III, Higher Education Act of 1965.

ERIC Educational Resources Information Center

Bullard, Richard F., Ed.

These 17 curriculum studies by faculty members of San Joaquin Delta Junior College were funded under Title III of The Higher Education Act of 1965. They were intended to help initiate new courses, improve existing ones, or plan for future ones. Each project report gave its objective(s), the general methods for its development and completion, the…

Jobs and Self-Sufficiency: Goals of the Project, "Technical Support Services to the Developmentally Disabled, Region III." Final Report, October 1976 to September 1979.

ERIC Educational Resources Information Center

Mallik, Kalisankar; Shaver, Elaine M.

The final report of a 3 year project to improve the quality of life of mentally retarded, cerebral palsied, and epileptic persons in Region III is presented. The first section details the efforts of the project staff in providing competitive employment opportunities or sheltered employment for 40 severely disabled persons. Equipment modification…

34 CFR 637.32 - What selection criteria does the Secretary use?

Code of Federal Regulations, 2010 CFR

2010-07-01

... POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION MINORITY SCIENCE AND ENGINEERING IMPROVEMENT PROGRAM How Does... project; (iii) A clear description of how the objectives of the project relate to the purpose of the... specific needs in science; and (iii) Involvement of appropriate individuals, especially science faculty, in...

Learning at a Distance in South Dakota: Description and Evaluation of the Diffusion of a Distance Education.

ERIC Educational Resources Information Center

Simonson, Michael; Bauck, Tamara

One major component of the efforts to promote the use of technology and distance education in South Dakota and specifically of Phase III of the Connecting the Schools Project-an initiative announced in the spring of 1999 by Governor Janklow that built a statewide intranet among all 176 school districts--was a comprehensive evaluation activity. The…

Long Valley Coring Project

USGS Publications Warehouse

Sass, John; Finger, John; McConnel, Vicki

1998-01-01

In December 1997, the California Energy Commission (CEC) agreed to provide funding for Phase III continued drilling of the Long Valley Exploratory Well (LVEW) near Mammoth Lakes, CA, from its present depth. The CEC contribution of $1 million completes a funding package of $2 million from a variety of sources, which will allow the well to be cored continuously to a depth of between 11,500 and 12,500 feet. The core recovered from Phase III will be crucial to understanding the origin and history of the hydrothermal systems responsible for the filling of fractures in the basement rock. The borehole may penetrate the metamorphic roof of the large magmatic complex that has fed the volcanism responsible for the caldera and subsequent activity.

Alteration of Occlusal Plane in Orthognathic Surgery: Clinical Features to Help Treatment Planning on Class III Patients

PubMed Central

Costa, Tony Eduardo; Barbosa, Saulo de Matos; Pereira, Rodrigo Alvitos; Chaves Netto, Henrique Duque de Miranda

2018-01-01

Dentofacial deformities (DFD) presenting mainly as Class III malocclusions that require orthognathic surgery as a part of definitive treatment. Class III patients can have obvious signs such as increasing the chin projection and chin throat length, nasolabial folds, reverse overjet, and lack of upper lip support. However, Class III patients can present different facial patterns depending on the angulation of occlusal plane (OP), and only bite correction does not always lead to the improvement of the facial esthetic. We described two Class III patients with different clinical features and inclination of OP and had undergone different treatment planning based on 6 clinical features: (I) facial type; (II) upper incisor display at rest; (III) dental and gingival display on smile; (IV) soft tissue support; (V) chin projection; and (VI) lower lip projection. These patients were submitted to orthognathic surgery with different treatment plannings: a clockwise rotation and counterclockwise rotation of OP according to their facial features. The clinical features and OP inclination helped to define treatment planning by clockwise and counterclockwise rotations of the maxillomandibular complex, and two patients undergone to bimaxillary orthognathic surgery showed harmonic outcomes and stables after 2 years of follow-up. PMID:29854480

Waveform Design for Multimedia Airborne Networks: Robust Multimedia Data Transmission in Cognitive Radio Networks

DTIC Science & Technology

2011-03-01

at the sensor. According to Candes, Tao and Romberg [1], a small number of random projections of a signal that is compressible is all the...Projection of Signal Transform i. DWT ii. FFT iii. DCT Solve the Minimization problem Reconstruct Signal Channel (AWGN ) De -noise Signal Original...Signal (Noisy) Random Projection of Signal Transform i. DWT ii. FFT iii. DCT Solve the Minimization problem Reconstruct Signal Channel (Noiseless) De

Application of Satellite SAR Imagery in Mapping the Active Layer of Arctic Permafrost

NASA Technical Reports Server (NTRS)

Zhang, Ting-Jun; Li, Shu-Sun

2003-01-01

The objective of this project is to map the spatial variation of the active layer over the arctic permafrost in terms of two parameters: (i) timing and duration of thaw period and (ii) differential frost heave and thaw settlement of the active layer. To achieve this goal, remote sensing, numerical modeling, and related field measurements are required. Tasks for the University of Colorado team are to: (i) determine the timing of snow disappearance in spring through changes in surface albedo (ii) simulate the freezing and thawing processes of the active layer and (iii) simulate the impact of snow cover on permafrost presence.

A combined electrophysiological and morphological study of neuropeptide Y–expressing inhibitory interneurons in the spinal dorsal horn of the mouse

PubMed Central

Iwagaki, Noboru; Ganley, Robert P.; Dickie, Allen C.; Polgár, Erika; Hughes, David I.; Del Rio, Patricia; Revina, Yulia; Watanabe, Masahiko; Todd, Andrew J.; Riddell, John S.

2015-01-01

Abstract The spinal dorsal horn contains numerous inhibitory interneurons that control transmission of somatosensory information. Although these cells have important roles in modulating pain, we still have limited information about how they are incorporated into neuronal circuits, and this is partly due to difficulty in assigning them to functional populations. Around 15% of inhibitory interneurons in laminae I-III express neuropeptide Y (NPY), but little is known about this population. We therefore used a combined electrophysiological/morphological approach to investigate these cells in mice that express green fluorescent protein (GFP) under control of the NPY promoter. We show that GFP is largely restricted to NPY-immunoreactive cells, although it is only expressed by a third of those in lamina I-II. Reconstructions of recorded neurons revealed that they were morphologically heterogeneous, but never islet cells. Many NPY-GFP cells (including cells in lamina III) appeared to be innervated by C fibres that lack transient receptor potential vanilloid-1, and consistent with this, we found that some lamina III NPY-immunoreactive cells were activated by mechanical noxious stimuli. Projection neurons in lamina III are densely innervated by NPY-containing axons. Our results suggest that this input originates from a small subset of NPY-expressing interneurons, with the projection cells representing only a minority of their output. Taken together with results of previous studies, our findings indicate that somatodendritic morphology is of limited value in classifying functional populations among inhibitory interneurons in the dorsal horn. Because many NPY-expressing cells respond to noxious stimuli, these are likely to have a role in attenuating pain and limiting its spread. PMID:26882346

Final project report for NEET pulsed ion beam project

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kucheyev, S. O.

The major goal of this project was to develop and demonstrate a novel experimental approach to access the dynamic regime of radiation damage formation in nuclear materials. In particular, the project exploited a pulsed-ion-beam method in order to gain insight into defect interaction dynamics by measuring effective defect interaction time constants and defect diffusion lengths. This project had the following four major objectives: (i) the demonstration of the pulsed ion beam method for a prototypical nuclear ceramic material, SiC; (ii) the evaluation of the robustness of the pulsed beam method from studies of defect generation rate effects; (iii) the measurementmore » of the temperature dependence of defect dynamics and thermally activated defect-interaction processes by pulsed ion beam techniques; and (iv) the demonstration of alternative characterization techniques to study defect dynamics. As we describe below, all these objectives have been met.« less

Excelsior Mining Arizona, Inc. Gunnison Copper Project Class III UIC Area Permit and Aquifer Exemption

EPA Pesticide Factsheets

UIC Area Permit R9UIC-AZ3-FY16-1 and supporting documents for Class III In-Situ Production of Copper: Gunnison Copper Project, Cochise County, AZ, issued to Excelsior Mining Arizona Inc., Concord Place, Suite 300, 2999 North 44th Street, Phoenix, AZ 85018.

Increasing Efficiency of Recruitment in Early Parkinson's Disease Trials: A Case Study Examination of the STEADY-PD III Trial.

PubMed

Berk, Sarah; Greco, Brittany L; Biglan, Kevin; Kopil, Catherine M; Holloway, Robert G; Meunier, Claire; Simuni, Tanya

2017-01-01

Challenges in clinical trial recruitment threaten the successful development of improved therapies. This is particularly true in Parkinson's disease (PD) studies of disease modification where the population of interest is difficult to find and study design is more complex. This paper seeks to understand how STEADY PD III, a National Institute of Neurological Disorders and Stroke (NINDS) funded phase 3 trial evaluating the efficacy of isradipine as a disease modifying agent for PD, was able to recruit their full target population 6 months ahead of schedule. STEADY PD III aimed to enroll 336 individuals with early stage idiopathic PD within 18 months using 57 sites across the United States and Canada. The study included a 10% NIH minority recruitment goal. Eligible participants agreed to be followed for up to 36 months, complete 12 in-person visits and 4 telephone visits. A Recruitment Committee of key stakeholders was critical in the development of a comprehensive recruitment strategy involving: multi-modal outreach, protocol modifications and comprehensive site selection and activation. Efforts to increase site-specific minority recruitment strategies were encouraged through additional funding. A total of 336 individuals, including 34 minorities, were enrolled within 12 months - 6 months ahead of the projected timeline. Quantitative analysis of recruitment activity questionnaires found that of the sites that completed them (n = 54), (20.4%) met goals, (24.1%) exceeded goals, and (55.6%) fell below projected goals. Referral sources completed at time of screening indicate top four study referral sources as: site personnel (53.8%); neurologists (24%); Fox Trial Finder (10.2%); and communications from The Michael J. Fox Foundation (3.9%). STEADY PD III serves as an important example of methods that can be used to increase clinical trial recruitment. This research highlights a continued need to improve site infrastructure and dedicate more resources to increased participation of minorities in clinical research.

Increasing Efficiency of Recruitment in Early Parkinson’s Disease Trials: A Case Study Examination of the STEADY-PD III Trial

PubMed Central

Berk, Sarah; Greco, Brittany L.; Biglan, Kevin; Kopil, Catherine M.; Holloway, Robert G.; Meunier, Claire; Simuni, Tanya

2017-01-01

Background: Challenges in clinical trial recruitment threaten the successful development of improved therapies. This is particularly true in Parkinson’s disease (PD) studies of disease modification where the population of interest is difficult to find and study design is more complex. Objective: This paper seeks to understand how STEADY PD III, a National Institute of Neurological Disorders and Stroke (NINDS) funded phase 3 trial evaluating the efficacy of isradipine as a disease modifying agent for PD, was able to recruit their full target population 6 months ahead of schedule. Methods: STEADY PD III aimed to enroll 336 individuals with early stage idiopathic PD within 18 months using 57 sites across the United States and Canada. The study included a 10% NIH minority recruitment goal. Eligible participants agreed to be followed for up to 36 months, complete 12 in-person visits and 4 telephone visits. A Recruitment Committee of key stakeholders was critical in the development of a comprehensive recruitment strategy involving: multi-modal outreach, protocol modifications and comprehensive site selection and activation. Efforts to increase site-specific minority recruitment strategies were encouraged through additional funding. Results: A total of 336 individuals, including 34 minorities, were enrolled within 12 months – 6 months ahead of the projected timeline. Quantitative analysis of recruitment activity questionnaires found that of the sites that completed them (n = 54), (20.4%) met goals, (24.1%) exceeded goals, and (55.6%) fell below projected goals. Referral sources completed at time of screening indicate top four study referral sources as: site personnel (53.8%); neurologists (24%); Fox Trial Finder (10.2%); and communications from The Michael J. Fox Foundation (3.9%). Conclusions: STEADY PD III serves as an important example of methods that can be used to increase clinical trial recruitment. This research highlights a continued need to improve site infrastructure and dedicate more resources to increased participation of minorities in clinical research. PMID:29103052

Biomedical Science, Unit III: The Circulatory System in Health and Science. The Heart and Blood Vessels; Blood and Its Properties; The Urinary Tract. Laboratory Manual. Revised Version, 1976.

ERIC Educational Resources Information Center

Biomedical Interdisciplinary Curriculum Project, Berkeley, CA.

This laboratory manual presents activities for a unit of science within the Biomedical Interdisciplinary Curriculum Project (BICP), a two-year interdisciplinary precollege curriculum aimed at preparing high school students for entry into college and vocational programs leading to a career in the health field. These twenty-five laboratory…

Fault-controlled development of shallow hydrothermal systems: Structural and mineralogical insights from the Southern Andes

NASA Astrophysics Data System (ADS)

Roquer, T.; Arancibia, G.; Rowland, J. V.; Iturrieta, P. C.; Morata, D.; Cembrano, J. M.

2017-12-01

Paleofluid-transporting systems can be recognized as meshes of fracture-filled veins in eroded zones of extinct hydrothermal systems. Here we conducted meso-microstructural analysis and mechanical modeling from two exhumed exposures of the faults governing regional tectonics of the Southern Andes: the Liquiñe-Ofqui Fault System (LOFS) and the Andean Transverse Faults (ATF). A total of 107 fractures in both exposures were analyzed. The ATF specific segment shows two tectonic solutions that can be modeled as Andersonian and non-Andersonian tectonic regimes: (1) shear (mode II/III) failure occurs at differential stresses > 28 MPa and fluid pressures < 40-80% lithostatic in the Andersonian regime; and (2) sporadic hybrid extensional + shear (modes I + II/III) failure occurs at differential stresses < 20 MPa and anomalously high fluid pressures > 85-98% lithostatic in the non-Andersonian regime. Additionally, the LOFS exposure cyclically fails in extension (mode I) or extension + shear (modes I + II/III) in the Andersonian regime, at differential stresses < 28 MPa and fluid pressures > 40-80% lithostatic. In areas of spatial interaction between ATF and LOFS, these conditions might favor: (1) the storage of overpressured fluids in hydrothermal systems associated with the ATF faults, and (2) continuous fluid flow through vertical conduits in the LOFS faults. These observations suggest that such intersections are highly probable locations for concentrated hydrothermal activity, which must be taken into consideration for further geothermal exploration. ACKNOWLEDGEMENTS. PhD CONICYT grants, Centro de Excelencia en Geotermia de los Andes (CEGA-FONDAP/CONICYT Project #15090013), FONDECYT Project #1130030 and Project CONICYT REDES #140036.

Evaluation Reports of ESEA, Title III Projects: Final Report, FY 1972.

ERIC Educational Resources Information Center

District of Columbia Public Schools, Washington, DC. Dept. of Research and Evaluation.

Through Title III of the Elementary Secondary Education Act of 1965, six programs were funded in Washington, D.C. public schools to meet the educational needs of handicapped disadvantaged children. One of the programs, the Columbia Road Pre-School Pilot Project was designed to serve as an experimental model for early childhood education for…

Eisenhower Pre-Service Teacher Education Project, Higher Education Consortium Region III. Final Report.

ERIC Educational Resources Information Center

Wozniak, Jacci

The Eisenhower Pre-Service Teacher Education Project was developed by the University of Central Florida, the five community colleges in Region III of the Higher Education Consortium, and the private college and universities in the same region to design curriculum changes to improve the preparation of elementary and secondary math and science…

Discovery: Guidelines for Establishing an Outdoor Education Program in Special Education, ESEA Title III Project.

ERIC Educational Resources Information Center

Bott, Kristine Ann; Bannasch, Donald Max

Funded through the 1965 Elementary and Secondary Education Act (ESEA) Title III, the Project began serving youngsters handicapped either physically, mentally, or emotionally, who qualified for special education services in the fall of 1971. Among its objectives were to: (1) improve these youngsters' achievement in reqular school subjects, their…

Definitions for the "No Child Left Behind Act of 2001": Scientifically-Based Research

ERIC Educational Resources Information Center

Wilde, Judith

2004-01-01

The U.S. Department of Education provides a great deal of support to education each year through formula funding (e.g., Title I, Title III services to students) and discretionary grants (e.g., Title III pro-fessional development grants, Safe Schools/Healthy Students projects). However, because evaluations of these projects, and many educational…

Goldsboro-Wayne County E.S.E.A. Title III. Final Evaluation Report, 1974-1975.

ERIC Educational Resources Information Center

Educational Planning and Evaluation Consultants, Inc., Chapel Hill, NC.

Contained in the final report is evaluation information for the Goldsboro-Wayne County (North Carolina) Elementary and Secondary Education Act Title III Project for 35 moderately, severely, and profoundly retarded children (3-16 years old) during the 1974-75 school year. The project was evaluated through analysis of behavior change data and…

Oregon Small Schools Program: A Title III Project. Independent Evaluation Report, 1972.

ERIC Educational Resources Information Center

Miller, Donald F.

An Elementary and Secondary Education Act (ESEA) Title III project, the 1971-72 Oregon Small Schools Program (OSSP) objectives were (1) to increase member schools receptivity to new and better ideas in education; (2) to implement new programs and apply new techniques consistent with the Oregon Board of Education priority objectives and with the…

High altitude chemical release systems for project BIME (Brazilian Ionospheric Modification Experiments) project IMS (Ionospheric Modification Studies) project PIIE (Polar Ionospheric Irregularities Experiment) project polar arcs

NASA Astrophysics Data System (ADS)

Stokes, Charles S.; Murphy, William J.

1987-07-01

Project BIME, a Spread F observation program involved the launching of two Nike-Black Brant rockets each containing a payload of Ammonium Nitrate Fuel Oil (ANFO). The rockets were launched from Barriera Do Inferno Launch Site in Natal, Brazil in August of 1982. Project IMS, an F-layer modification experiment involved three launch vehicles, a Nike-Tomahawk and two Sonda III rockets. The Nike-Tomahawk carried a sulfur hexafluoride (SF6) payload. One of the Sonda III rockets carried a payload that consisted of an SF6 canister and a samarium/strontium thermite canister. The remaining Sonda III carried a trifluorobromo methane (CF3Br) canister and a samarium thermite canister. The rockets were launched from Wallops Island Launch Facility, Virginia in November of 1984. Project PIIE and Polar Arcs, a program to investigate polar ionospheric irregularities, involved a Nike-Black Brant rocket carrying one samarium thermite canister and six barium canisters. An attempted launch failed when launch criteria could not be met. The rocket was launched successfully from Sondrestrom Air Base, Greenland in March 1987.

Advanced Natural Gas Reciprocating Engines(s)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zurlo, James

The ARES program was initiated in 2001 to improve the overall brake thermal efficiency of stationary, natural gas, reciprocating engines. The ARES program is a joint award that is shared by Dresser, Inc., Caterpillar and Cummins. The ARES program was divided into three phases; ARES I (achieve 44% BTE), ARES II (achieve 47% BTE) and ARES III (achieve 50% BTE). Dresser, Inc. completed ARES I in March 2005 which resulted in the commercialization of the APG1000 product line. ARES II activities were completed in September 2010 and the technology developed is currently being integrated into products. ARES III activities beganmore » in October 2010. The ARES program goal is to improve the efficiency of natural gas reciprocating engines. The ARES project is structured in three phases with higher efficiency goals in each phase. The ARES objectives are as follows: 1. Achieve 44% (ARES I), 47% (ARES II), and 50% brake thermal efficiency (BTE) as a final ARES III objective 2. Achieve 0.1 g/bhp-hr NOx emissions (with after-treatment) 3. Reduce the cost of the produced electricity by 10% 4. Improve or maintain reliability, durability and maintenance costs« less

How much will it cost to eradicate lymphatic filariasis? An analysis of the financial and economic costs of intensified efforts against lymphatic filariasis.

PubMed

Kastner, Randee J; Sicuri, Elisa; Stone, Christopher M; Matwale, Gabriel; Onapa, Ambrose; Tediosi, Fabrizio

2017-09-01

Lymphatic filariasis (LF), a neglected tropical disease (NTD) preventable through mass drug administration (MDA), is one of six diseases deemed possibly eradicable. Previously we developed one LF elimination scenario, which assumes MDA scale-up to continue in all countries that have previously undertaken MDA. In contrast, our three previously developed eradication scenarios assume all LF endemic countries will undertake MDA at an average (eradication I), fast (eradication II), or instantaneous (eradication III) rate of scale-up. In this analysis we use a micro-costing model to project the financial and economic costs of each of these scenarios in order to provide evidence to decision makers about the investment required to eliminate and eradicate LF. Costing was undertaken from a health system perspective, with all results expressed in 2012 US dollars (USD). A discount rate of 3% was applied to calculate the net present value of future costs. Prospective NTD budgets from LF endemic countries were reviewed to preliminarily determine activities and resources necessary to undertake a program to eliminate LF at a country level. In consultation with LF program experts, activities and resources were further reviewed and a refined list of activities and necessary resources, along with their associated quantities and costs, were determined and grouped into the following activities: advocacy and communication, capacity strengthening, coordination and strengthening partnerships, data management, ongoing surveillance, monitoring and supervision, drug delivery, and administration. The costs of mapping and undertaking transmission assessment surveys and the value of donated drugs and volunteer time were also accounted for. Using previously developed scenarios and deterministic estimates of MDA duration, the financial and economic costs of interrupting LF transmission under varying rates of MDA scale-up were then modelled using a micro-costing approach. The elimination scenario, which includes countries that previously undertook MDA, is estimated to cost 929 million USD (95% Credible Interval: 884m-972m). Proceeding to eradication is anticipated to require a higher financial investment, estimated at 1.24 billion USD (1.17bn-1.30bn) in the eradication III scenario (immediate scale-up), with eradication II (intensified scale-up) projected at 1.27 billion USD (1.21bn-1.33bn), and eradication I (slow scale-up) estimated at 1.29 billion USD (1.23bn-1.34bn). The economic costs of the eradication III scenario are estimated at approximately 7.57 billion USD (7.12bn-7.94bn), while the elimination scenario is projected to have an economic cost of 5.21 billion USD (4.91bn-5.45bn). Countries in the AFRO region will require the greatest investment to reach elimination or eradication, but also stand to gain the most in cost savings. Across all scenarios, capacity strengthening and advocacy and communication represent the greatest financial costs, whereas mapping, post-MDA surveillance, and administration comprise the least. Though challenging to implement, our results indicate that financial and economic savings are greatest under the eradication III scenario. Thus, if eradication for LF is the objective, accelerated scale-up is projected to be the best investment.

Contractors Road Heavy Equipment Area SWMU 055 Corrective Measures Implementation Progress Report

NASA Technical Reports Server (NTRS)

Dorman, Lane

2015-01-01

This Corrective Measures Implementation (CMI) Progress Report, Revision 1, for Contractor's Road Heavy Equipment (CRHE) Area Solid Waste Management Unit (SWMU) Number 055 was prepared by Geosyntec Consultants (Geosyntec) for the National Aeronautics and Space Administration (NASA) under contract number NNK09CA02B, Delivery Order NNK09CA62D and Project Number PCN ENV-2324. This CMI Progress Report documents: (i) activities conducted as part of supplemental assessment activities completed from June 2009 through November 2014; (ii) Engineering Evaluation (EE) Advanced Data Packages (ADPs); and (iii) recommendations for future activities related to corrective measures at the Site.

A Process Evaluation of Project Developmental Continuity. Interim Report III, Executive Summary: Preliminary Recommendations for the Study of Child Impact.

ERIC Educational Resources Information Center

Granville, Arthur C.; And Others

This executive summary presents the major findings of Interim Report III, which reports preliminary evaluation of Project Developmental Continuity (PDC). A Head Start demonstration program, PDC is aimed at promoting greater educational and developmental continuity as children make the transition from preschool to school. The report addresses three…

A Sequenced Instructional Program in Physical Education for the Handicapped, Phase III. Producing and Disseminating Demonstration Packages. Final Report.

ERIC Educational Resources Information Center

Carr, Dorothy B.; Avance, Lyonel D.

Presented is a sequenced instructional program in physical education which constitutes the third of a three-phase, 4-year project, funded by Title III, for handicapped children, preschool through high school levels, in the Los Angeles Unified School District. Described are the project setting and the following accomplishments: a curriculum guide…

Harrison Educational Research and Development Center. End of Project Period Evaluation Report ESEA, Title III. FY 1971-1972.

ERIC Educational Resources Information Center

Harrison Educational Research and Development Center, AR.

Evaluated is a 2 year project in Harrison School District 1, Arkansas, funded through Title III, to develop academic and/music based instructional materials in two resource rooms for learning disabled (LD), educationally disadvantaged, and mentally retarded children; and to integrate art and music with social studies in grades 1 through 6.…

Educating for Landpower

DTIC Science & Technology

2009-03-23

UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Captain Albert Lord Department of Military Strategy, Planning, and Operations 8...RESEARCH PROJECT EDUCATING FOR LANDPOWER by Lieutenant Colonel Michael S. Lewis United States Army Captain Albert Lord Project Adviser This SRP is...Napoleon ler; Publiee par ordre de l’empereur Napoleon III, 1858-1869, [Herafter Correspondance.], III, 2392 “Au President de L’Institut National [ Camus

A sense of urgency: Evaluating the link between clinical trial development time and the accrual performance of cancer therapy evaluation program (NCI-CTEP) sponsored studies.

PubMed

Cheng, Steven K; Dietrich, Mary S; Dilts, David M

2010-11-15

Postactivation barriers to oncology clinical trial accruals are well documented; however, potential barriers prior to trial opening are not. We investigate one such barrier: trial development time. National Cancer Institute Cancer Therapy Evaluation Program (CTEP)-sponsored trials for all therapeutic, nonpediatric phase I, I/II, II, and III studies activated between 2000 and 2004 were investigated for an 8-year period (n = 419). Successful trials were those achieving 100% of minimum accrual goal. Time to open a study was the calendar time from initial CTEP submission to trial activation. Multivariate logistic regression analysis was used to calculate unadjusted and adjusted odds ratios (OR), controlling for study phase and size of expected accruals. Among the CTEP-approved oncology trials, 37.9% (n = 221) failed to attain the minimum accrual goals, with 70.8% (n = 14) of phase III trials resulting in poor accrual. A total of 16,474 patients (42.5% of accruals) accrued to those studies were unable to achieve the projected minimum accrual goal. Trials requiring less than 12 months of development were significantly more likely to achieve accrual goals (OR, 2.15; 95% confidence interval, 1.29-3.57, P = 0.003) than trials with the median development times of 12 to 18 months. Trials requiring a development time of greater than 24 months were significantly less likely to achieve accrual goals (OR, 0.40; 95% confidence interval, 0.20-0.78; P = 0.011) than trials with the median development time. A large percentage of oncology clinical trials do not achieve minimum projected accruals. Trial development time appears to be one important predictor of the likelihood of successfully achieving the minimum accrual goals. ©2010 AACR.

Material Science

NASA Image and Video Library

2002-08-06

Khalid Alshibli of Louisiana State University, project scientist for the Mechanics of Granular Materials (MGM-III) experiment, uses a jar of sand and a training model of the MGM apparatus to explain the experiment to two young Virginia students. The activity was part of the Space Research and You education event held by NASA's Office of Biological and Physical Research on June 25, 2002, in Arlington, VA, to highlight the research that will be conducted on STS-107.

Project FARE task III report : urban mass transportation industry reporting system design : interim task III report for November 1972-June 1973 period. Part III - Reporting system forms.

DOT National Transportation Integrated Search

1973-06-01

The report contains a description of the proposed uniform reporting system for the urban mass transit industry. It is presented in four volumes: Part I - Task Summary contains a description of how Task III was accomplished and the conclusions and rec...

Analysis and Evaluation of 137 ESEA Title III Planning and Operational Grants. Report No. 4 of the Second National Study of PACE.

ERIC Educational Resources Information Center

Fairfax County Schools, Baileys Crossroads, VA. Center for Effecting Educational Change.

This report is an assessment of the overall impact and influence on education of 137 terminated Planning and Operational Grants made under the ESEA Title III Projects to Advance Creativity in Education (PACE) program. Analysis and evaluation seek to determine whether (1) individual project objectives were identified and achieved, (2) PACE…

Advertising; Glossary of Key Words. Vocational Reading Power Project, Title III, E.S.E.A.

ERIC Educational Resources Information Center

Tibbetts, Judith

The glossary is one of twenty in various subject areas of vocational education designed to assist the student in vocabulary mastery for particular vocational education courses. They are part of the Vocational Reading Power Project, Title III, E.S.E.A. This glossary is for a course in advertising. It is divided into two parts: one provides the…

Individualized Inservice Teacher Education (Project In-Step). Evaluation Report. Phase III.

ERIC Educational Resources Information Center

Thurber, John C.

This is a report on the third phase of Project IN-STEP, which was intended to develop a viable model for individualized, multi-media in-service teacher education programs. (Phase I and II are reported in ED 033 905, and ED 042 709). The rationale for Phase III was to see if the model could be successfully transferred to an area other than teaching…

Lessons learnt from Volcanoes' Night I-II-III - a Marie Curie Researchers' Night project series dedicated to geosciences

NASA Astrophysics Data System (ADS)

Cseko, Adrienn; Bodo, Balazs; Ortega Rodriguez, Ariadna

2017-04-01

European Researchers' Nights (ERNs) are a pan-European series of events funded by the European Commission, organised on the last Friday of every September since 2005. ERNs mobilise scientific, academic and research organisations with the aim of giving the public the opportunity to meet researchers in an informal setting. The overall objective of ERNs is to achieve better awareness among the general public concerning the importance of science in everyday life and to combat stereotypes about researchers. The longer-term strategic objective of ERNs is to encourage young people to embark on a scientific career. Volcanoes' Night I-II-III has been an ERN project series funded by the EC FP7 and H2020 programmes between 2012-2015 (EC contract No. 316558, 610050, 633310, www.nochedevolcanes.es). The concept of Volcanoes' Night was created by researchers from the Canary Islands, Spain, where both the researchers and the public live in the close vicinity of volcanoes. The objective of the project was to use volcanoes as a background against which the role of geoscientists could be explained to the public. The scope of Volcanoes' Night was exclusively dedicated to geoscience, and in this respect it stands out among all other ERN projects, which are always more general in scope. During its four years of EC funding, the geographical coverage of Volcanoes' Night expanded substantially from a single location in 2012 (Fuencaliente de La Palma, Spain) to a dozen locations in 2015, mobilising multiple scientific organisations, researchers, and public authorities for engagement with the public. The last EC-funded project, Volcanoes' Night III, which was organised in 2014 and 2015, engaged approximately 21,000 visitors through its outreach activities, which included experiments, science cafés, volcano movies, My Day presentations, excursions, science workshops and more. The impact of the project was carefully assessed via surveys and social studies during its lifetime, and an Impact Assessment Report was submitted to the EC after the conclusion of each of the three projects. According to an on-site survey undertaken in 2015, 78.5% of responders reported that their initial understanding of the work of geoscientists improved as a result of the activities organised during the event. The conclusions from the Impact Assessment studies can be used to synthesise methodological recommendations for other organisations that may consider the organisation of similar public outreach actions for geosciences in the future. Scientific experiments are most efficient to raise interest if they are designed for direct engagement with the public so participants can participate in the experiments themselves as opposed to being simple observers. Scientific talks should always include a good level of interaction with the public, for example integrated experiments, quizzes, and real-time surveys. Edutainment options should be finalised in agreement with the audience so that the most interesting ones are selected - this is especially important to create meaningful engagement with young people. The definition of the scope of activities in a way that allows for the inclusion of interdisciplinary subjects (e.g. the intersection of geoscience and robotics) can raise the interest of an even greater public community.

Morphological characterization of rat entorhinal neurons in vivo: soma-dendritic structure and axonal domains.

PubMed

Lingenhöhl, K; Finch, D M

1991-01-01

We used in vivo intracellular labeling with horseradish peroxidase in order to study the soma-dendritic morphology and axonal projections of rat entorhinal neurons. The cells responded to hippocampal stimulation with inhibitory postsynaptic potentials, and thus likely received direct or indirect hippocampal input. All cells (n = 24) showed extensive dendritic domains that extended in some cases for more than 1 mm. The dendrites of layer II neurons were largely restricted to layers I and II or layers I-III, while the dendrites of deeper cells could extend through all cortical layers. Computed 3D rotations showed that the basilar dendrites of deep pyramids extended roughly parallel to the cortical layering, and that they were mostly confined to the layer containing the soma and layers immediately adjacent. Total dendritic lengths averaged 9.8 mm +/- 3.8 (SD), and ranged from 5 mm to more than 18 mm. Axonal processes could be visualized in 21 cells. Most of these showed axonal branching within the entorhinal cortex, sometimes extensive. Efferent axonal domains were reconstructed in detail in 3 layer II stellate cells. All 3 projected axons across the subicular complex to the dentate gyrus. One of these cells showed an extensive net-like axonal domain that also projected to several other structures, including the hippocampus proper, subicular complex, and the amygdalo-piriform transition area. The axons of layer III and IV cells projected to the angular bundle, where they continued in a rostral direction. In contrast to the layer II, III and IV cells, no efferent axonal branches leaving the entorhinal cortex could be visualized in 5 layer V neurons. The data indicate that entorhinal neurons can integrate input from a considerable volume of entorhinal cortex by virtue of their extensive dendritic domains, and provide a further basis for specifying the layers in which cells receive synaptic input. The extensive axonal branching pattern seen in most of the cells would support divergent propagation of their activity.

Supplement Analysis for the Watershed Management Program Final EIS (DOE EIS /SA-156) - Upper Salmon River Anadromous Fish Passage Improvement Projects

DOE Office of Scientific and Technical Information (OSTI.GOV)

Keller, Carl J.

2004-07-13

BPA proposes to fund IDFG to plan and complete construction of fish passage improvements and water conservation activities that are contained within IDFG’s Statement of Work (SOW) for the period 7/1/04 to 6/30/05. The funding request contained in their SOW is part of an ongoing IDFG effort to fund anadromous fish passage projects that fall outside the scope of the Mitchell Act. The proposed SOW activities fall within the following four categories: Phase I-Planning and Design (gather data, perform investigations, and exchange information; perform surveys and assessments to be compliant; survey project sites and perform engineering designs; perform contract andmore » project management); Phase II-Construction and Implementation (procure materials and supplies, prepare contracts and solicit bids, plant native seedlings, complete capital improvements); Phase III-Operation and Maintenance (maintain office operations); and Phase IV- Monitoring and Evaluation (monitor and evaluate post-project effects, reporting). The SOW culminates with proposed construction of 18 capital improvement projects (Table 1 attached). The types of capital improvements include: screening gravity water diversions; consolidating and/or eliminating ditches; evaluating and screening pump diversions; evaluating and implementing water conservation activities; constructing screens along migration routes and rearing areas for hatchery and wild salmon; improving upstream and downstream passage for anadromous fish; and maximize benefits to aquatic habitat. Because each of the proposed projects in the SOW is still in the planning stages, the specifics of each still need to be completed.« less

Observational and Modeling-based Study of Corsica Thunderstorms: Preparation of the EXAEDRE Airborne Campaign

NASA Astrophysics Data System (ADS)

Defer, E.; Coquillat, S.; Lambert, D.; Pinty, J. P.; Prieur, S.; Caumont, O.; Labatut, L.; Nuret, M.; Blanchet, P.; Buguet, M.; Lalande, P.; Labrouche, G.; Pedeboy, S.; Lojou, J. Y.; Schwarzenboeck, A.; Delanoë, J.; Bourdon, A.; Guiraud, L.

2017-12-01

The 4-year EXAEDRE (EXploiting new Atmospheric Electricity Data for Research and the Environment; Oct 2016-Sept 2020) project is sponsored by the French Science Foundation ANR (Agence Nationale de la Recherche). This project is a French contribution to the HyMeX (HYdrological cycle in the Mediterranean EXperiment) program. The EXAEDRE activities rely on innovative multi-disciplinary and state of the art instrumentation and modeling tools to provide a comprehensive description of the electrical activity in thunderstorms. The EXAEDRE observational part is based on i) existing lightning records collected during HyMeX Special Observation Period (SOP1; Sept-Nov 2012), and permanent lightning observations provided by the research Lightning Mapping Array SAETTA and the operational Météorage lightning locating systems, ii) additional lightning observations mapped with a new VHF interferometer especially developed within the EXAEDRE project, and iii) a dedicated airborne campaign over Corsica. The modeling part of the EXAEDRE project exploits the electrification and lightning schemes developed in the cloud resolving model MesoNH and promotes an innovative technique of flash data assimilation in the french operational model AROME of Météo-France. An overview of the EXAEDRE project will be given with an emphasis on the instrumental, observational and modeling activities performed during the 1st year of the project. The preparation of the EXAEDRE airborne campaign scheduled for September 2018 over Corsica will then be discussed. Acknowledgements. The EXAEDRE project is sponsored by grant ANR-16-CE04-0005 with support from the MISTRALS/HyMeX meta program.

Benchmarking the Integration of WAVEWATCH III Results into HAZUS-MH: Preliminary Results

NASA Technical Reports Server (NTRS)

Berglund, Judith; Holland, Donald; McKellip, Rodney; Sciaudone, Jeff; Vickery, Peter; Wang, Zhanxian; Ying, Ken

2005-01-01

The report summarizes the results from the preliminary benchmarking activities associated with the use of WAVEWATCH III (WW3) results in the HAZUS-MH MR1 flood module. Project partner Applied Research Associates (ARA) is integrating the WW3 model into HAZUS. The current version of HAZUS-MH predicts loss estimates from hurricane-related coastal flooding by using values of surge only. Using WW3, wave setup can be included with surge. Loss estimates resulting from the use of surge-only and surge-plus-wave-setup were compared. This benchmarking study is preliminary because the HAZUS-MH MR1 flood module was under development at the time of the study. In addition, WW3 is not scheduled to be fully integrated with HAZUS-MH and available for public release until 2008.

Evidence for a hyperglycaemia-dependent decrease of antithrombin III-thrombin complex formation in humans.

PubMed

Ceriello, A; Giugliano, D; Quatraro, A; Marchi, E; Barbanti, M; Lefèbvre, P

1990-03-01

In the presence of increased levels of fibrinopeptide A, decreased antithrombin III biological activity, and thrombin-antithrombin III complex levels are seen in diabetic patients. Induced-hyperglycaemia in diabetic and normal subjects decreased antithrombin III activity and thrombin-antithrombin III levels, and increased fibrinopeptide A plasma levels, while antithrombin III concentration did not change; heparin was shown to reduced these phenomena. In diabetic patients, euglycaemia induced by insulin infusion restored antithrombin III activity, thrombin-antithrombin III complex and fibrinopeptide A concentrations; heparin administration had the same effects. These data stress the role of a hyperglycaemia-dependent decrease of antithrombin III activity in precipitating thrombin hyperactivity in diabetes mellitus.

III-Nitride Based Optoelectronics

DTIC Science & Technology

2010-01-01

carrier gas67 is known to affect the atomic composition of etched ZnO surface. In our research, we have used x- ray microanalysis to gather...Project (0704-0188.) Washington, DC 20503. 1. AGENCY USE ONLY ( Leave Blank) 2. REPORT DATE 03/2010 3. REPORT TYPE AND DATES COVERED Final...Introduction 2 2.2 Experiment 3 2.2.1 Growth and Material Characterization 3 2.2.2 Preparation of high quality LEO GaN 3 2.2.3 Blue and green active

Analysis of Data for the Development of Density and Composition Models of the Upper Atmosphere.

DTIC Science & Technology

1981-07-01

8217 //( Luigi G.acchia / F19628-78-C-0126 / Jack W./Slowey " _ S. PERFORIONG ORGANIZATION NAME AND ADDRESS 10. PROGRAM ELEMENT. PROJECT, TASK Smithsonian...Variation: Overviev . ......so.*. 6 rIII. Longitudinally Averaged Model ............0 9 IV. Local-time Dependent Model...............o 13 V.* Future Work...are no significant residuals between the observed and computed values at the equator for even the highest levels of geomagnetic activity. The equatorial

Material Science

NASA Image and Video Library

2002-08-06

Khalid Alshibli of Louisiana State University, project scientist for the Mechanics of Granular Materials (MGM-III) experiment, explains the MGM experiment to Kristen Erickson, acting deputy associate administrator in NASA's Office of Biological and Physical Research. A training model of the test cell is at right. The activity was part of the Space Research and You education event held by NASA's Office of Biological and Physical Research on June 25, 2002, in Arlington, VA, to highlight the research that will be conducted on STS-107.

Material Science

NASA Image and Video Library

2002-08-06

Khalid Alshibli of Louisiana State University, project scientist for the Mechanics of Granular Materials (MGM-III) experiment, uses a jar of sand as he explains MGM to NASA Administrator Sean O'Keefe. A training model of an MGM test cell is in the foreground. The activity was part of the Space Research and You education event held by NASA's Office of Biological and Physical Research on June 25, 2002, in Arlington, VA, to highlight the research that will be conducted on STS-107.

Characterizing the stellar population of a sample of star forming galaxies with high emission of both [OIV]25.9um and [NeII]12.8um

NASA Astrophysics Data System (ADS)

Martínez-Paredes, M.; Bruzual, G.; Meléndez, M.; González-Martín, O.

2017-11-01

The optical diagnostic diagram te{BPT81, VO87} allow us to discriminate between the different excitation mechanism, like that produce by young stars and that produce by the AGN during the accretion of matter onto the super massive black hole. This kind of tool are important because allow us to study the connection between starburst and AGN. However, despite the great success, the identification of the most heavily dust-obscured systems remains a challenge for optical diagrams. Mid-infrared diagnostic are more suitable to study dust-enshrouded systems, where the effect of dust obscuration can hamper the interpretation of traditional optical diagnostics, since in this spectral range we have access to low-ionization lines (as [Ne II]12.8μm) typical of star forming regions and high ionization lines typical of active galaxies ([OIV]25.9μm), while intermediate ionization-lines ([Ne III]15.3μm) provide a unique scenario where the AGN coexist with active star formation in the host galaxy. In a previous work te{Melendez14} we have carried out extensive and detailed photoionization modeling to successfully separate the different excitation mechanism in the mid-infrared diagnostic diagrams proposed by te{Weaver10}. We successfully modelled the AGN and starburst galaxies ratios lines of [NeIII]/[NeII] Vs [OIV]/[NeIII]. However, we failed in modelling the observed ratio lines in galaxies with a normal star formation activity ([NeIII]/[NeII]<1 and [OIV]/[NeIII]<1). These results suggest the presence of a more complex excitation mechanism in these galaxies. In this project we are using the update stellar population models from te{BC17} that include massive stars, and the update photoionization models from CLOUDY from te{Ferland17}, to characterize the properties of the stellar population that produce the high ionization conditions in these galaxies.

Integrator element as a promoter of active learning in engineering teaching

NASA Astrophysics Data System (ADS)

Oliveira, Paulo C.; Oliveira, Cristina G.

2014-03-01

In this paper, we present a teaching proposal used in an Introductory Physics course to civil engineering students from Porto's Engineering Institute/Instituto Superior de Engenharia do Porto (ISEP). The proposal was born from the need to change students' perception and motivation for learning physics. It consists in the use of an integrator element, called the physics elevator project. This integrator element allows us to use, in a single project, all the content taught in the course and uses several active learning strategies. In this paper, we analyse this project as: (i) a clarifying element of the contents covered in the course; (ii) a promoter element of motivation and active participation in class and finally and (iii) a link between the contents covered in the course and the 'real world'. The data were collected by a questionnaire and interviews to students. From the data collected, it seems that the integrator element improves students' motivation towards physics and develops several skills that they consider to be important to their professional future. It also acts as a clarifying element and makes the connection between the physics that is taught and the 'real world'.

SENER molten salt tower technology. Ouarzazate NOOR III case

NASA Astrophysics Data System (ADS)

Relloso, Sergio; Gutiérrez, Yolanda

2017-06-01

NOOR III 150 MWe project is the evolution of Gemasolar (19.9 MWe) to large scale Molten Salt Tower plants. With more than 5 years of operational experience, Gemasolar lessons learned have been the starting point for the optimization of this technology, considered the leader of potential cost reduction in CSP. In addition, prototypes of plant key components (heliostat and receiver) were manufactured and thoroughly tested before project launch in order to prove the new engineering solutions adopted. The SENER proprietary technology of NOOR III will be applied in the next Molten Salt Tower plants that will follow in other countries, such as South Africa, Chile and Australia.

Effects of the type III secreted pseudomonal toxin ExoS in the yeast Saccharomyces cerevisiae.

PubMed

Stirling, Fiona R; Evans, Tom J

2006-08-01

Pseudomonas aeruginosa secretes a number of toxins by a type III system, and these are important in virulence. One of them, ExoS, is a bifunctional toxin, with a GTPase-activating protein domain, as well as ADP ribosyltransferase (ADPRT) activity. These two domains have numerous potential cellular targets, but the overall mechanism of ExoS action remains unclear. The effects of ExoS in a simple eukaryotic system, the yeast Saccharomyces cerevisiae, using a tetracycline-regulated expression system were studied. This system allowed controlled expression of ExoS in yeast, which was not possible using a galactose-induced system. ExoS was found to be an extremely potent inhibitor of yeast growth, and to be largely dependent on the activity of its ADPRT domain. ExoS produced a dramatic alteration in actin distribution, with the appearance of large aggregates of cortical actin, and thickened disorganized cables, entirely dependent on the ADPRT domain. This phenotype is suggestive of actin stabilization, which was verified by showing that the cortical aggregates of actin induced by ExoS were resistant to treatment with latrunculin A, an agent that prevents actin polymerization. ExoS increased the numbers of mating projections produced following growth arrest with mating pheromone, and prevented subsequent DNA replication, an effect that is again dependent on the ADPRT domain. Following pheromone removal, ExoS produced altered development of the mating projections, which became elongated with a swollen bud-like tip. These results suggest alternative pathways for ExoS action in eukaryotic cells that may result from activation of small GTPases, and this yeast expression system is well suited to explore these pathways.

7 CFR 3400.6 - Grant awards.

Code of Federal Regulations, 2013 CFR

2013-01-01

... such purpose, the awarding official shall make research project grants to those responsible, eligible... project period shall be no later than September 30 of the Federal fiscal year in which the project is... research project grant under the terms of this part; (ii) Title of project; (iii) Name(s) and address(es...

The Sulcis Storage Project: Status of the First Italian Initiative for Pilot-Scale Geological Sequestration of CO2

NASA Astrophysics Data System (ADS)

Plaisant, A.; Maggio, E.; Pettinau, A.

2016-12-01

The deep aquifer located at a depth of about 1000-1500 m within fractured carbonate in the Sulcis coal basin (South-West Sardinia, Italy) constitutes a potential reservoir to develop a pilot-scale CO2 storage site. The occurrence of several coal mines and the geology of the basin also provide favourable condition to install a permanent infrastructures where advanced CO2 storage technologies can be developed. Overall, the Sulcis project will allow to characterize the Sulcis coal basin (South West Sardinia, Italy) and to develop a permanent infrastructure (know-how, equipment, laboratories, etc.) for advanced international studies on CO2 storage. The research activities are structured in two different phases: (i) site characterization, including the construction of an underground and a fault laboratories and (ii) the installation of a test site for small-scale injection of CO2. In particular, the underground laboratory will host geochemical and geophysical experiments on rocks, taking advantages of the buried environment and the very well confined conditions in the galleries; in parallel, the fault laboratory will be constructed to study CO2 leakage phenomena in a selected fault. The project is currently ongoing and some preliminary results will be presented in this work as well as the structure of the project as a whole. More in detail, preliminary activities comprise: (i) geochemical monitoring; (ii) the minero-petrographycal, physical and geophysical characterization of the rock samples; (iii) the development of both static and dynamic geological models of the reservoir; (iv) the structural geology and fault analysis; (v) the assessment of natural seismicity through a monitoring network (vi) the re-processing and the analysis of the reflection seismic data. Future activities will comprise: (i) the drilling of shallow exploration wells near the faults; (ii) the construction of both the above mentioned laboratories; (iii) drilling of a deep exploration well (1,500 m); (iv) injection tests. Preliminary analyses show that the rocks of the carbonate formation present a low porosity, but the formation is characterized by a good permeability for fractures and karst. The faults are typically sealed and petrophysical properties of caprock and reservoir are spatially heterogeneous.

How much will it cost to eradicate lymphatic filariasis? An analysis of the financial and economic costs of intensified efforts against lymphatic filariasis

PubMed Central

Kastner, Randee J.; Sicuri, Elisa; Stone, Christopher M.; Matwale, Gabriel; Onapa, Ambrose; Tediosi, Fabrizio

2017-01-01

Introduction Lymphatic filariasis (LF), a neglected tropical disease (NTD) preventable through mass drug administration (MDA), is one of six diseases deemed possibly eradicable. Previously we developed one LF elimination scenario, which assumes MDA scale-up to continue in all countries that have previously undertaken MDA. In contrast, our three previously developed eradication scenarios assume all LF endemic countries will undertake MDA at an average (eradication I), fast (eradication II), or instantaneous (eradication III) rate of scale-up. In this analysis we use a micro-costing model to project the financial and economic costs of each of these scenarios in order to provide evidence to decision makers about the investment required to eliminate and eradicate LF. Methodology/Key findings Costing was undertaken from a health system perspective, with all results expressed in 2012 US dollars (USD). A discount rate of 3% was applied to calculate the net present value of future costs. Prospective NTD budgets from LF endemic countries were reviewed to preliminarily determine activities and resources necessary to undertake a program to eliminate LF at a country level. In consultation with LF program experts, activities and resources were further reviewed and a refined list of activities and necessary resources, along with their associated quantities and costs, were determined and grouped into the following activities: advocacy and communication, capacity strengthening, coordination and strengthening partnerships, data management, ongoing surveillance, monitoring and supervision, drug delivery, and administration. The costs of mapping and undertaking transmission assessment surveys and the value of donated drugs and volunteer time were also accounted for. Using previously developed scenarios and deterministic estimates of MDA duration, the financial and economic costs of interrupting LF transmission under varying rates of MDA scale-up were then modelled using a micro-costing approach. The elimination scenario, which includes countries that previously undertook MDA, is estimated to cost 929 million USD (95% Credible Interval: 884m-972m). Proceeding to eradication is anticipated to require a higher financial investment, estimated at 1.24 billion USD (1.17bn-1.30bn) in the eradication III scenario (immediate scale-up), with eradication II (intensified scale-up) projected at 1.27 billion USD (1.21bn-1.33bn), and eradication I (slow scale-up) estimated at 1.29 billion USD (1.23bn-1.34bn). The economic costs of the eradication III scenario are estimated at approximately 7.57 billion USD (7.12bn-7.94bn), while the elimination scenario is projected to have an economic cost of 5.21 billion USD (4.91bn-5.45bn). Countries in the AFRO region will require the greatest investment to reach elimination or eradication, but also stand to gain the most in cost savings. Across all scenarios, capacity strengthening and advocacy and communication represent the greatest financial costs, whereas mapping, post-MDA surveillance, and administration comprise the least. Conclusions/Significance Though challenging to implement, our results indicate that financial and economic savings are greatest under the eradication III scenario. Thus, if eradication for LF is the objective, accelerated scale-up is projected to be the best investment. PMID:28949987

25 CFR 163.40 - Indian and Alaska Native forestry education assistance.

Code of Federal Regulations, 2011 CFR

2011-04-01

... forestry-related field which could include courses on indigenous culture; and (iii) To create an... technologies as well as native indigenous forestry technologies; (iii) Involve students in projects and...

25 CFR 163.40 - Indian and Alaska Native forestry education assistance.

Code of Federal Regulations, 2012 CFR

2012-04-01

... forestry-related field which could include courses on indigenous culture; and (iii) To create an... technologies as well as native indigenous forestry technologies; (iii) Involve students in projects and...

25 CFR 163.40 - Indian and Alaska Native forestry education assistance.

Code of Federal Regulations, 2013 CFR

2013-04-01

... forestry-related field which could include courses on indigenous culture; and (iii) To create an... technologies as well as native indigenous forestry technologies; (iii) Involve students in projects and...

25 CFR 163.40 - Indian and Alaska Native forestry education assistance.

Code of Federal Regulations, 2014 CFR

2014-04-01

... forestry-related field which could include courses on indigenous culture; and (iii) To create an... technologies as well as native indigenous forestry technologies; (iii) Involve students in projects and...

Louisiana SIP: LAC 33:III Ch. 14 Subchap B, 1431 to 1434--Conformity to State or Federal Implementation Plans of Transportation Plans, Programs, and Projects Developed, Funded, or Approved Under Title 23 U.S.C. or the Federal Transit Laws

EPA Pesticide Factsheets

Louisiana SIP: LAC 33:III Ch. 14 Subchap B, 1431 to 1434--Conformity to State or Federal Implementation Plans of Transportation Plans, Programs, and Projects Developed, Funded, or Approved Under Title 23 U.S.C. or the Federal Transit Laws

24 CFR 266.630 - Partial payment of claims.

Code of Federal Regulations, 2010 CFR

2010-04-01

... HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Contract... other resources available to the project are sufficient to restore the financial viability of the project; (iii) The project is or can (at reasonable cost) be made structurally sound; (iv) The management...

Influence of organic substrates on the kinetics of bacterial As(III) oxidation

NASA Astrophysics Data System (ADS)

Lescure, T.; Joulian, C.; Bauda, P.; Hénault, C.; Battaglia-Brunet, F.

2012-04-01

Soil microflora plays a major role on the behavior of metals and metalloids. Arsenic speciation, in particular, is related to the activity of bacteria able to oxidize, reduce or methylate this element, and determines mobility, bioavailability and toxicity of As. Arsenite (AsIII) is more toxic and more mobile than arsenate (AsV). Bacterial As(III)-oxidation tends to reduce the toxicity of arsenic in soils and the risk of transfer toward underlying aquifers, that would affect the quality of water resources. Previous results suggest that organic matter may affect kinetics or efficiency of bacterial As(III)-oxidation in presence of oxygen, thus in conventional physico-chemical conditions of a surface soil. Different hypothesis can be proposed to explain the influence of organic matter on As(III) oxidation. Arsenic is a potential energy source for bacteria. The presence of easily biodegradable organic matter may inhibit the As(III) oxidation process because bacteria would first metabolize these more energetic substrates. A second hypothesis would be that, in presence of organic matter, the Ars system involved in bacterial resistance to arsenic would be more active and would compete with the Aio system of arsenite oxidation, decreasing the global As(III) oxidation rate. In addition, organic matter influences the solubility of iron oxides which often act as the main pitfalls of arsenic in soils. The concentration and nature of organic matter could therefore have a significant influence on the bioavailability of arsenic and hence on its environmental impact. The influence of organic matter on biological As(III) oxidation has not yet been determined in natural soils. In this context, soil amendment with organic matter during operations of phytostabilization or, considering diffuse pollutions, through agricultural practices, may affect the mobility and bio-availability of the toxic metalloid. The objective of the present project is to quantify the influence of organic matter on the bacterial speciation of arsenic in contaminated soils. Moreover, the biogeochemical consequences of this phenomenon on the mobility and ecotoxicity of this metalloid will be studied. The first task of this program is the precise and systematic investigation of the influence of different types and concentrations of organic matters on the activity of As(III)-oxidizing pure strains. Influence of aspartate, succinate (simple substrates) and yeast extract (complex substrate) on As(III)-oxidation kinetics has been studied. For each experiment, the bacterial growth and the expression of genes involved in the speciation of arsenic, i.e. aio and ars genes, has been monitored. A direct perspective of this work will be to perform experiments with humic and fulvic acids (complex organic matter commonly found in soils), and with water-extracted organic matter from polluted soils. Then the As(III)-oxidation activity of bacterial communities extracted from contaminated soils will be followed. These assays should allow the screening of conditions which will be applied in subsequent experiments with several real contaminated soils, including a former mining site, impacted industrial sites, and a forest soil heavily contaminated after arsenical ammunitions storage. This work is co-funded by BRGM and ADEME (convention TEZ 11-16).

Project FARE task III report : urban mass transportation industry reporting system design : interim task III report for November 1972-June 1973 period. Part I - Task summary.

DOT National Transportation Integrated Search

1973-06-01

This report contains a description of the proposed uniform reporting system for the urban mass transit industry. It is presented in four volumes: Part I - Task Summary contains a description of how Task III was accomplished and the conclusions and re...

Electronic construction collaboration system : phase III.

DOT National Transportation Integrated Search

2011-12-01

This phase of the electronic collaboration project involved two major efforts: 1) implementation of AEC Sync (formerly known as Attolist), a web-based project management system (WPMS), on the Broadway Viaduct Bridge Project and the Iowa Falls Arch Br...

Applied Meteorology Unit (AMU)

NASA Technical Reports Server (NTRS)

Bauman, William H., Jr.; Crawford, Winifred; Short, David; Barrett, Joe; Watson, Leela

2008-01-01

This report summarizes the Applied Meteorology Unit (AMU) activities for the second quarter of Fiscal Year 2008 (January - March 2008). Projects described are: (1) Peak Wind Tool for User Launch Commit Criteria (LCC), (2) Peak Wind Tool for General Forecasting, (3) Situational Lightning Climatologies for Central Florida. Phase III, (4) Volume Averaged Height Integrated Radar Reflectivity (VAHIRR), (5) Impact of Local Sensors, (6) Radar Scan Strategies for the PAFB WSR-74C Replacement and (7) WRF Wind Sensitivity Study at Edwards Air Force Base.

European Scientific Notes. Volume 34. Number 5,

DTIC Science & Technology

1980-05-31

rrr--England4s Cold WLnter of 1978-79 N.V. Burt 214 Appleton Lab Looks to the Future P. Fire 216 Ii]i 10 m Allen Clark Research Centre- Plessey Rsearch ...activities range (MTR) facilities, Dr. J.R ’Nor- will continue at Slough in support of bury has designed and begun to operate work which is now going... experimental link at Slough upper-atmosphere balloon projects, has been operated under computer con- about 10 deal with ionospheric propaga- trol at

Khalid Alshibli shows a child MGM apparatus at outreach event

NASA Technical Reports Server (NTRS)

2002-01-01

Khalid Alshibli of Louisiana State University, project scientist for the Mechanics of Granular Materials (MGM-III) experiment, uses a jar of sand and a training model of the MGM apparatus to explain the experiment to two young Virginia students. The activity was part of the Space Research and You education event held by NASA's Office of Biological and Physical Research on June 25, 2002, in Arlington, VA, to highlight the research that will be conducted on STS-107.

Khalid Alshibli explains MGM to Sean O'Keefe

NASA Technical Reports Server (NTRS)

2002-01-01

Khalid Alshibli of Louisiana State University, project scientist for the Mechanics of Granular Materials (MGM-III) experiment, uses a jar of sand as he explains MGM to NASA Administrator Sean O'Keefe. A training model of an MGM test cell is in the foreground. The activity was part of the Space Research and You education event held by NASA's Office of Biological and Physical Research on June 25, 2002, in Arlington, VA, to highlight the research that will be conducted on STS-107.

Development and testing of responder : phase III.

DOT National Transportation Integrated Search

2017-06-28

This report documents the research project Development and Testing of Responder Phase III. Under previous research, a Responder system has been developed to provide relevant and timely information to first responders, allow responders to provid...

Healthy city projects in developing countries: the first evaluation.

PubMed

Harpham, T; Burton, S; Blue, I

2001-06-01

The 'healthy city' concept has only recently been adopted in developing countries. From 1995 to 1999, the World Health Organization (WHO), Geneva, supported healthy city projects (HCPs) in Cox's Bazar (Bangladesh), Dar es Salaam (Tanzania), Fayoum (Egypt), Managua (Nicaragua) and Quetta (Pakistan). The authors evaluated four of these projects, representing the first major evaluation of HCPs in developing countries. Methods used were stakeholder analysis, workshops, document analysis and interviews with 102 managers/implementers and 103 intended beneficiaries. Municipal health plan development (one of the main components of the healthy city strategy) in these cities was limited, which is a similar finding to evaluations of HCPs in Europe. The main activities selected by the projects were awareness raising and environmental improvements, particularly solid waste disposal. Two of the cities effectively used the 'settings' approach of the healthy city concept, whereby places such as markets and schools are targeted. The evaluation found that stakeholder involvement varied in relation to: (i) the level of knowledge of the project; (ii) the project office location; (iii) the project management structure; and (iv) type of activities (ranging from low stakeholder involvement in capital-intensive infrastructure projects, to high in some settings-type activities). There was evidence to suggest that understanding of environment-health links was increased across stakeholders. There was limited political commitment to the healthy city projects, perhaps due to the fact that most of the municipalities had not requested the projects. Consequently, the projects had little influence on written/expressed municipal policies. Some of the projects mobilized considerable resources, and most projects achieved effective intersectoral collaboration. WHO support enabled the project coordinators to network at national and international levels, and the capacity of these individuals (although not necessarily their institutions) was increased by the project. The average annual running cost of the projects was approximately 132,000 US dollars per city, which is close to the costs of the only other HCP for which a cost analysis has been undertaken, Bangkok (115,000 US dollars per year) Recommendations for these and other HCPs are provided.

Identification and Optimization of New Leads for Malaria Vector Control.

PubMed

Hueter, Ottmar F; Hoppé, Mark; Wege, Philip; Maienfisch, Peter

2016-10-01

A significant proportion of the world's population remains at risk from malaria, and whilst great progress has been made in reducing the number of malaria cases globally through the use of vector control insecticides, these gains are under threat from the emergence of insecticide resistance. The spread of resistance in the vector populations, principally to pyrethroids, is driving the need for the development of new tools for malaria vector control. In order to identify new leads 30,000 compounds from the Syngenta corporate chemical collection were tested in a newly developed screening platform. More than 3000 compounds (10%) showed activity at ≤200 mg active ingredient (AI) litre -1 against Anopheles stephensi. Further evaluation resulted in the identification of 12 viable leads for the control of adult mosquitoes, most originating from current or former insecticide projects. Surprisingly, one of these leads emerged from a former PPO herbicide project and one from a former complex III fungicide project. This indicates that representatives of certain herbicide and fungicide projects and modes of action can also represent a valuable source of leads for malaria vector control. Optimization of the diphenyl ether lead 1 resulted in the identification of the cyano-pyridyl compound 31. This compound 31 exhibits good activity against mosquito species including rdl resistant Anopheles. It is only slightly weaker than permethrin and does not show relevant levels of cross-resistance to the organochlorine insecticide dieldrin.

Phase III Archives | NOAA Gulf Spill Restoration

Science.gov Websites

III Early Restoration Plan and Draft Early Restoration PEIS Executive Summary (pdf, 3.4 MB) Project Summary Table (pdf, 80 KB) Public Repositories (pdf, 113 KB) Press Release (pdf, 501 KB) Press Release

Cooperative Electronic Mail: Effective Communication Technology for Introductory Chemistry

NASA Astrophysics Data System (ADS)

Pence, Laura E.

1999-05-01

One drawback to using cooperative learning in the classroom is that it takes up class time and reduces the amount of content that can be covered during a semester. Cooperative electronic mail is an excellent alternate method of using cooperative learning that shifts the medium of interaction to the computer and encourages students to learn to communicate effectively through technology. In this project, three types of exercises were assigned, one prior to each exam. These three assignments were (i) an open-ended question, (ii) a traditional cooperative activity done electronically, and (iii) an exercise to allow students to write exam questions for each other. The average participation rate in the exercises was 90% over four semesters, which indicated that the project was an effective incentive to get students to use email regularly. The evaluations of the project were also extremely positive. One surprising result of the assessment was that female students gave even more favorable responses than men, suggesting that this project was an excellent way to encourage women to use computer technology.

One of the possible mechanisms for the inhibition effect of Tb(III) on peroxidase activity in horseradish (Armoracia rusticana) treated with Tb(III).

PubMed

Guo, Shaofen; Cao, Rui; Lu, Aihua; Zhou, Qing; Lu, Tianhong; Ding, Xiaolan; Li, Chaojun; Huang, Xiaohua

2008-05-01

One of the possible mechanisms for the inhibition effect of Tb(III) on peroxidase activity in horseradish (Armoracia rusticana) treated with Tb(III) was investigated using some biophysical and biochemical methods. Firstly, it was found that a large amount of Tb(III) can be distributed on the cell wall, that some Tb(III) can enter into the horseradish cell, indicating that peroxidase was mainly distributed on cell wall, and thus that Tb(III) would interact with horseradish peroxidase (HRP) in the plant. In addition, peroxidase bioactivity was decreased in the presence of Tb(III). Secondly, a new peroxidase-containing Tb(III) complex (Tb-HRP) was obtained from horseradish after treatment with Tb(III); the molecular mass of Tb-HRP is near 44 kDa and the pI is about 8.80. Thirdly, the electrocatalytic activity of Tb-HRP is much lower than that of HRP obtained from horseradish without treatment with Tb(III). The decrease in the activity of Tb-HRP is due to the destruction (unfolding) of the conformation in Tb-HRP. The planarity of the heme active center in the Tb-HRP molecule was increased and the extent of exposure of Fe(III) in heme was decreased, leading to inhibition of the electron transfer. The microstructure change in Tb-HRP might be the result of the inhibition effect of Tb(III) on peroxidase activity in horseradish.

14 CFR 158.24 - Notice and opportunity for public comment.

Code of Federal Regulations, 2010 CFR

2010-01-01

... TRANSPORTATION (CONTINUED) AIRPORTS PASSENGER FACILITY CHARGES (PFC'S) Application and Approval § 158.24 Notice... project(s) the public agency is considering for funding by PFC's; (ii) A brief justification for each project the public agency is considering for funding by PFC's; (iii) The PFC level for each project; (iv...

14 CFR 158.24 - Notice and opportunity for public comment.

Code of Federal Regulations, 2014 CFR

2014-01-01

... TRANSPORTATION (CONTINUED) AIRPORTS PASSENGER FACILITY CHARGES (PFC'S) Application and Approval § 158.24 Notice... project(s) the public agency is considering for funding by PFC's; (ii) A brief justification for each project the public agency is considering for funding by PFC's; (iii) The PFC level for each project; (iv...

14 CFR 158.24 - Notice and opportunity for public comment.

Code of Federal Regulations, 2013 CFR

2013-01-01

... TRANSPORTATION (CONTINUED) AIRPORTS PASSENGER FACILITY CHARGES (PFC'S) Application and Approval § 158.24 Notice... project(s) the public agency is considering for funding by PFC's; (ii) A brief justification for each project the public agency is considering for funding by PFC's; (iii) The PFC level for each project; (iv...

14 CFR 158.24 - Notice and opportunity for public comment.

Code of Federal Regulations, 2011 CFR

2011-01-01

... TRANSPORTATION (CONTINUED) AIRPORTS PASSENGER FACILITY CHARGES (PFC'S) Application and Approval § 158.24 Notice... project(s) the public agency is considering for funding by PFC's; (ii) A brief justification for each project the public agency is considering for funding by PFC's; (iii) The PFC level for each project; (iv...

14 CFR 158.24 - Notice and opportunity for public comment.

Code of Federal Regulations, 2012 CFR

2012-01-01

... TRANSPORTATION (CONTINUED) AIRPORTS PASSENGER FACILITY CHARGES (PFC'S) Application and Approval § 158.24 Notice... project(s) the public agency is considering for funding by PFC's; (ii) A brief justification for each project the public agency is considering for funding by PFC's; (iii) The PFC level for each project; (iv...

75 FR 11530 - Crystal Lake Wind III, LLC, et al.; Notice of Effectiveness of Exempt Wholesale Generator Status

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-11

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Crystal Lake Wind III, LLC, et al.; Notice of Effectiveness of Exempt Wholesale Generator Status March 4, 2010. Docket Nos. Crystal Lake Wind III, LLC EG10-6-000 GardenGarden Wind, LLC EG10-7-000 Star Point Wind Project LLC EG10-8-000...

Findings from an Evaluation of a Comprehensive Parent Education Program for School-Age Parents.

ERIC Educational Resources Information Center

Braun, Maureen H.; Fuscaldo, Diane P.

This study evaluates the impact of the Parent Linking Project III (PLP III) on its participants. The PLP III is a comprehensive program for teenage mothers which offers workshops in parenting, mother-child interaction, and vocational awareness, and provides day care services that allow teen mothers to take the opportunity to complete their high…

Project FARE task III report : urban mass transportation industry reporting system design : interim task III report for November 1972-June 1973 period. Part IV - Commuter rail reporting.

DOT National Transportation Integrated Search

1973-06-01

This report contains a description of the proposed uniform reporting system for the urban mass transit industry. It is presented in four volumes: Part I - Task Summary contains a description of how Task III was accomplished and the conclusions and re...

Project FARE task III report : urban mass transportation industry reporting system design : interim task III report for November 1972-June 1973 period. Part II - Reporting system instructions.

DOT National Transportation Integrated Search

1973-06-01

This report contains a description of the proposed uniform reporting system for the urban mass transit industry. It is presented in four volumes: Part I - Task Summary contains a description of how Task III was accomplished and the conclusions and re...

"India Population Projects" in Karnataka.

PubMed

Reddy, P H; Badari, V S

1991-12-01

An overview, objectives, implementation, and research and evaluation studies of 2 India Population Projects in Karnataka are presented. The India Population Project I (IPP-I) was conducted in Karnataka and Uttar Pradesh. India Population Project III (IPP-III) took place between 1984-92 in 6 districts of Karnataka: Belgaum, Bijapur, Dharwad, Bidar, Gulbarga, and Raichur, and 4 districts in Kerala. The 6 districts in Karnataka accounted for 36% (13.2 million) of the total national population. The project cost was Rs. 713.1 million which was shared by the World Bank, and the Indian national and regional government. Due to poor past performance, these projects were undertaken to improve health and family welfare status. Specific project objectives are outlined. IPP-I included an urban component, and optimal Government of India program, and an intensive rural initiative. The urban program aimed to improved pre- and postnatal services and facilities, and the family planning (FP) in Bangalore city. The rural program was primarily to provide auxiliary nurse-midwives and hospitals and clinics, and also supplemental feeding program for pregnant and nursing mothers and children up to 2 years. The government program provided FP staff and facilities. IPP-I had 3 units to oversee building construction, to recruit staff and provide supplies and equipment, and to establish a Population Center. IPP-III was concerned with service delivery; information, education, and communication efforts (IEC) and population education; research and evaluation; and project management. Both projects contributed significantly to improving the infrastructure. A brief account of the types and kinds of studies undertaken is given. Studies were grouped into longitudinal studies of fertility, mortality, and FP; management information and evaluation systems for health and family welfare programs; experimental strategies; and other studies. Research and evaluation studies in IPP-III encompassed studies in gaps in knowledge, skills, and practice of health and FP personnel; baseline and endline surveys; and operational evaluation of the management information and evaluation system; factors affecting primary health care in Gulbarga district; evaluation of radio health lessons and the impact of the Kalyana Matha Program; and studies of vaccination and child survival and maternal mortality. Training programs were also undertaken.

SAGE III Educational Outreach and Student's On-Line Atmospheric Research

NASA Astrophysics Data System (ADS)

Woods, D. C.; Moore, S. W.; Walters, S. C.

2002-05-01

Students On-Line Atmospheric Research (SOLAR) is a NASA-sponsored educational outreach program aimed at raising the level of interest in science among elementary, middle, and high school students. SOLAR is supported by, and closely linked to, NASA's Stratospheric Aerosol and Gas Experiment III (SAGE III). SAGE III, launched on a Russian METEOR 3M spacecraft in December 2001, is a key component of NASA's Earth Observing System. It will monitor the quantity and distribution of aerosols, ozone, clouds, and other important trace gases in the upper atmosphere. Early data from SAGE III indicate that the instrument is performing as expected. SAGE III measurements will extend the long-term data record established by its predecessors, SAGE I and SAGE II, which spans from 1979 to the present. In addition, SAGE III's added measurement capabilities will provide more detailed data on certain atmospheric species. SOLAR selects interesting topics related to the science issues addressed by the SAGE III experiments, and develops educational materials and projects to enhance science teaching, and to help students realize the relevance of these issues to our lives on Earth. For example, SOLAR highlights some of the major questions regarding the health of the atmosphere such as possible influences of aerosols on global climate, and atmospheric processes related to ozone depletion. The program features projects to give students hands-on experience with scientific equipment and help develop skills in collecting, analyzing, and reporting science results. SOLAR focuses on helping teachers become familiar with current research in the atmospheric sciences, helping teachers integrate SOLAR developed educational materials into their curriculum. SOLAR gives special presentations at national and regional science teacher conferences and conducts a summer teacher workshop at the NASA Langley Research Center. This poster will highlight some of the key features of the SOLAR program and will present descriptions of student projects, teacher workshops, and SOLAR resources.

Anisotropy of the nitrogen conduction states in the group III nitrides studied by polarized x-ray absorption

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lawniczak-Jablonska, K.; Liliental-Weber, Z.; Gullikson, E.M.

1997-04-01

Group III nitrides (AlN, GaN, and InN) consist of the semiconductors which appear recently as a basic materials for optoelectronic devices active in the visible/ultraviolet spectrum as well as high-temperature and high-power microelectronic devices. However, understanding of the basic physical properties leading to application is still not satisfactory. One of the reasons consists in unsufficient knowledge of the band structure of the considered semiconductors. Several theoretical studies of III-nitrides band structure have been published but relatively few experimental studies have been carried out, particularly with respect to their conduction band structure. This motivated the authors to examine the conduction bandmore » structure projected onto p-states of the nitrogen atoms for AlN, GaN and InN. An additional advantage of their studies is the availability of the studied nitrides in two structures, hexagonal (wurtzite) and cubic (zincblende). This offers an opportunity to gain information about the role of the anisotropy of electronic band states in determining various physical properties.« less

Structural and functional characterization of two unusual endonuclease III enzymes from Deinococcus radiodurans.

PubMed

Sarre, Aili; Ökvist, Mats; Klar, Tobias; Hall, David R; Smalås, Arne O; McSweeney, Sean; Timmins, Joanna; Moe, Elin

2015-08-01

While most bacteria possess a single gene encoding the bifunctional DNA glycosylase Endonuclease III (EndoIII) in their genomes, Deinococcus radiodurans possesses three: DR2438 (DrEndoIII1), DR0289 (DrEndoIII2) and DR0982 (DrEndoIII3). Here we have determined the crystal structures of DrEndoIII1 and an N-terminally truncated form of DrEndoIII3 (DrEndoIII3Δ76). We have also generated a homology model of DrEndoIII2 and measured activity of the three enzymes. All three structures consist of two all α-helical domains, one of which exhibits a [4Fe-4S] cluster and the other a HhH-motif, separated by a DNA binding cleft, similar to previously determined structures of endonuclease III from Escherichia coli and Geobacillus stearothermophilus. However, both DrEndoIII1 and DrEndoIII3 possess an extended HhH motif with extra helical features and an altered electrostatic surface potential. In addition, the DNA binding cleft of DrEndoIII3 seems to be less accessible for DNA interactions, while in DrEndoIII1 it seems to be more open. Analysis of the enzyme activities shows that DrEndoIII2 is most similar to the previously studied enzymes, while DrEndoIII1 seems to be more distant with a weaker activity towards substrate DNA containing either thymine glycol or an abasic site. DrEndoIII3 is the most distantly related enzyme and displays no detectable activity towards these substrates even though the suggested catalytic residues are conserved. Based on a comparative structural analysis, we suggest that the altered surface potential, shape of the substrate-binding pockets and specific amino acid substitutions close to the active site and in the DNA interacting loops may underlie the unexpected differences in activity. Copyright © 2015 Elsevier Inc. All rights reserved.

33 CFR 385.30 - Master Implementation Sequencing Plan.

Code of Federal Regulations, 2010 CFR

2010-07-01

... projects of the Plan, including pilot projects and operational elements, based on the best scientific... Florida Water Management District shall also consult with the South Florida Ecosystem Restoration Task...; (ii) Information obtained from pilot projects; (iii) Updated funding information; (iv) Approved...

Stratospheric Aerosol and Gas Experiment, SAGE III on ISS, An Earth Science Mission on the International Space Station, Schedule Risk Analysis, A Project Perspective

NASA Technical Reports Server (NTRS)

Bonine, Lauren

2015-01-01

The presentation provides insight into the schedule risk analysis process used by the Stratospheric Aerosol and Gas Experiment III on the International Space Station Project. The presentation focuses on the schedule risk analysis process highlighting the methods for identification of risk inputs, the inclusion of generic risks identified outside the traditional continuous risk management process, and the development of tailored analysis products used to improve risk informed decision making.

The perforant path projection to hippocampal area CA1 in the rat hippocampal-entorhinal cortex combined slice.

PubMed

Empson, R M; Heinemann, U

1995-05-01

1. The perforant path projection from layer III of the entorhinal cortex to CA1 of the hippocampus was studied within a hippocampal-entorhinal combined slice preparation. We prevented contamination from the other main hippocampal pathways by removal of CA3 and the dentate gyrus. 2. Initially the projection was mapped using field potential recordings that suggested an excitatory sink in stratum lacunosum moleculare with an associated source in stratum pyramidale. 3. However, recording intracellularly from CA1 cells, stimulation of the perforant path produced prominent fast GABAA and slow GABAB IPSPs often preceded by small EPSPs. In a small number of cells we observed EPSPs only. 4. CNQX blocked excitatory and inhibitory responses. This indicated the presence of an intervening excitatory synapse between the inhibitory interneurone and the pyramidal cell. 5. Focal bicuculline applications revealed that the major site of GABAA inhibitory input was to stratum radiatum of CA1. 6. The inhibition activated by the perforant path was very effective at reducing simultaneously activated Schaffer collateral mediated EPSPs and suprathreshold-stimulated action potentials. 7. Blockade of fast inhibition increased excitability and enhanced slow inhibition. Both increases relied upon the activation of NMDA receptors. 8. Perforant path inputs activated prominent and effective disynaptic inhibition of CA1 cells. This has significance for the output of hippocampal processing during normal behaviour and also under pathological conditions.

Discussions with adults and youth to inform the development of a community-based tobacco control programme

PubMed Central

Arora, Monika; Tewari, Abha; Dhavan, Poonam; Nazar, Gaurang P.; Stigler, Melissa H.; Juneja, Neeru S.; Perry, Cheryl L.; Reddy, K. Srinath

2013-01-01

Project Advancing Cessation of Tobacco in Vulnerable Indian Tobacco Consuming Youth (ACTIVITY) is a community-based group randomized intervention trial focused on disadvantaged youth (aged 10–19 years) residing in 14 low-income communities (slums and resettlement colonies) in Delhi, India. This article discusses the findings of Focus Group Discussions (FGDs) conducted to inform the development and test the appropriateness of Project ACTIVITY’s intervention model. The findings of the FGDs facilitated the understanding of factors contributing to increased tobacco uptake and cessation (both smoking and smokeless tobacco) among youth in this setting. Twenty-two FGDs were conducted with youth (10–19 years) and adults in two urban slums in Delhi. Key findings revealed: (i) youth and adults had limited knowledge about long-term health consequences of tobacco use; (ii) socio-environmental determinants and peer pressure were important variables influencing initiation of tobacco use; (iii) lack of motivation, support and sufficient skills hinder tobacco cessation and (iv) active involvement of community, family, religious leaders, local policy makers and health professionals is important in creating and reinforcing tobacco-free norms. The results of these FGDs aided in finalizing the intervention model for Project ACTIVITY and guided its intervention development. PMID:22824533

46 CFR 298.27 - Advances.

Code of Federal Regulations, 2010 CFR

2010-10-01

... other sources, (iii) The measures that you are taking and have taken to alleviate the situation, (iv) Financial projections, (v) Proposed term of the repayment, (vi) Current and projected market conditions...

Performance Evaluation and Parameter Identification on DROID III

NASA Technical Reports Server (NTRS)

Plumb, Julianna J.

2011-01-01

The DROID III project consisted of two main parts. The former, performance evaluation, focused on the performance characteristics of the aircraft such as lift to drag ratio, thrust required for level flight, and rate of climb. The latter, parameter identification, focused on finding the aerodynamic coefficients for the aircraft using a system that creates a mathematical model to match the flight data of doublet maneuvers and the aircraft s response. Both portions of the project called for flight testing and that data is now available on account of this project. The conclusion of the project is that the performance evaluation data is well-within desired standards but could be improved with a thrust model, and that parameter identification is still in need of more data processing but seems to produce reasonable results thus far.

Intracellular recordings of subnucleus reticularis dorsalis neurones revealed novel electrophysiological properties and windup mechanisms

PubMed Central

Soto, Cristina; Canedo, Antonio

2011-01-01

Abstract Aδ- and/or C-fibre nociceptive inputs drive subnucleus reticularis dorsalis (SRD) neurones projecting to a variety of regions including the spinal cord and the nucleus reticularis gigantocellularis (NRGc), but their electrophysiological properties are largely unknown. Here we intracellularly recorded the SRD neuronal responses to injection of polarising current pulses as well as to electrical stimulation of the cervical spinal posterior quadrant (PQ) and the NRGc. Three different classes of neurones with distinct electrophysiological properties were found: type I were characterised by the absence of a fast postspike hyperpolarisation, type II by the presence of a postspike hyperpolarisation followed by a depolarisation resembling low threshold calcium spikes (LTSs), and type III (lacking LTSs) had a fast postspike hyperpolarisation deinactivating A-like potassium channels leading to enlarged interspike intervals. All three classes generated depolarising sags to hyperpolarising current pulses and showed 3–4.5 Hz subthreshold oscillatory activity leading to windup when intracellularly injecting low-frequency repetitive depolarising pulses as well as in response to 0.5–2 Hz NRGc and PQ electrical stimulation. About half of the 132 sampled neurones responded antidromically to NRGc stimulation with more than 65% of the NRGc-antidromic cells, pertaining to all three types, also responding antidromically to PQ stimulation. NRGc stimulation induced exclusively excitatory first-synaptic-responses whilst PQ stimulation induced first-response excitation in most cases, but inhibitory postsynaptic potentials in a few type II and type III neurones not projecting to the spinal cord that also displayed cumulative inhibitory effects (inverse windup). The results show that SRD cells (i) can actively regulate different temporal firing patterns due to their intrinsic electrophysiological properties, (ii) generate windup upon gradual membrane depolarisation produced by low-frequency intracellular current injection and by C-fibre tonic input, both processes leading subthreshold oscillations to threshold, and (iii) collateralise to the NRGc and the spinal cord, potentially providing simultaneous regulation of ascending noxious information and motor reactions to pain. PMID:21746779

Intracellular recordings of subnucleus reticularis dorsalis neurones revealed novel electrophysiological properties and windup mechanisms.

PubMed

Soto, Cristina; Canedo, Antonio

2011-09-01

Aδ- and/or C-fibre nociceptive inputs drive subnucleus reticularis dorsalis (SRD) neurones projecting to a variety of regions including the spinal cord and the nucleus reticularis gigantocellularis (NRGc), but their electrophysiological properties are largely unknown. Here we intracellularly recorded the SRD neuronal responses to injection of polarising current pulses as well as to electrical stimulation of the cervical spinal posterior quadrant (PQ) and the NRGc. Three different classes of neurones with distinct electrophysiological properties were found: type I were characterised by the absence of a fast postspike hyperpolarisation, type II by the presence of a postspike hyperpolarisation followed by a depolarisation resembling low threshold calcium spikes (LTSs), and type III (lacking LTSs) had a fast postspike hyperpolarisation deinactivating A-like potassium channels leading to enlarged interspike intervals. All three classes generated depolarising sags to hyperpolarising current pulses and showed 3-4.5 Hz subthreshold oscillatory activity leading to windup when intracellularly injecting low-frequency repetitive depolarising pulses as well as in response to 0.5-2 Hz NRGc and PQ electrical stimulation. About half of the 132 sampled neurones responded antidromically to NRGc stimulation with more than 65% of the NRGc-antidromic cells, pertaining to all three types, also responding antidromically to PQ stimulation. NRGc stimulation induced exclusively excitatory first-synaptic-responses whilst PQ stimulation induced first-response excitation in most cases, but inhibitory postsynaptic potentials in a few type II and type III neurones not projecting to the spinal cord that also displayed cumulative inhibitory effects (inverse windup). The results show that SRD cells (i) can actively regulate different temporal firing patterns due to their intrinsic electrophysiological properties, (ii) generate windup upon gradual membrane depolarisation produced by low-frequency intracellular current injection and by C-fibre tonic input, both processes leading subthreshold oscillations to threshold, and (iii) collateralise to the NRGc and the spinal cord, potentially providing simultaneous regulation of ascending noxious information and motor reactions to pain.

North Carolina "Sealed Corridor" Phase I, II, and III Assessment

DOT National Transportation Integrated Search

2009-10-01

The Federal Railroad Administration (FRA) tasked the John A. Volpe National Transportation Systems Center to document the further success of the North Carolina DOT "Sealed Corridor" project through Phases I, II, and III. The Sealed Corridor is the se...

Federal Programs Supporting Educational Change, Vol. 2: Factors Affecting Change Agent Projects.

ERIC Educational Resources Information Center

Berman, Paul; Pauly, Edward W.

This second volume in the change-agent series reports the interim results of an exploratory statistical analysis of a survey of a nationwide sample of 293 change-agent projects funded by four federal demonstration programs--Elementary Secondary Education Act (ESEA) Title III, Innovative Projects; ESEA Title VII, Bilingual Projects; Vocational…

33 CFR 385.26 - Project Implementation Reports.

Code of Federal Regulations, 2014 CFR

2014-07-01

... available science; (iii) Comply with all applicable Federal, State, and Tribal laws; (iv) Contain sufficient... boundary of regional computer models or projects whose effects cannot be captured in regional computer...

33 CFR 385.26 - Project Implementation Reports.

Code of Federal Regulations, 2011 CFR

2011-07-01

... available science; (iii) Comply with all applicable Federal, State, and Tribal laws; (iv) Contain sufficient... boundary of regional computer models or projects whose effects cannot be captured in regional computer...

33 CFR 385.26 - Project Implementation Reports.

Code of Federal Regulations, 2012 CFR

2012-07-01

... available science; (iii) Comply with all applicable Federal, State, and Tribal laws; (iv) Contain sufficient... boundary of regional computer models or projects whose effects cannot be captured in regional computer...

33 CFR 385.26 - Project Implementation Reports.

Code of Federal Regulations, 2013 CFR

2013-07-01

... available science; (iii) Comply with all applicable Federal, State, and Tribal laws; (iv) Contain sufficient... boundary of regional computer models or projects whose effects cannot be captured in regional computer...

Patient-Reported Outcomes in Sentinel Node–Negative Adjuvant Breast Cancer Patients Receiving Sentinel-Node Biopsy or Axillary Dissection: National Surgical Adjuvant Breast and Bowel Project Phase III Protocol B-32

PubMed Central

Land, Stephanie R.; Kopec, Jacek A.; Julian, Thomas B.; Brown, Ann M.; Anderson, Stewart J.; Krag, David N.; Christian, Nicholas J.; Costantino, Joseph P.; Wolmark, Norman; Ganz, Patricia A.

2010-01-01

Purpose Sentinel lymph node resection (SNR) may reduce morbidity while providing the same clinical utility as conventional axillary dissection (AD). National Surgical Adjuvant Breast and Bowel Project (NSABP) B-32 is a randomized phase III trial comparing SNR immediately followed by AD (SNAD) to SNR and subsequent AD if SN is positive. We report the definitive patient-reported outcomes (PRO) comparisons. Patients and Methods Eligible patients had clinically node-negative, operable invasive breast cancer. The PRO substudy included all SN-negative participants enrolled May 2001 to February 2004 at community institutions in the United States (n = 749; 78% age ≥ 50; 87% clinical tumor size ≤ 2.0 cm; 84% lumpectomy; 87% white). They completed questionnaires presurgery, 1 and 2 to 3 weeks postoperatively, and every 6 months through year 3. Arm symptoms, arm use avoidance, activity limitations, and quality of life (QOL) were compared with intent-to-treat two-sample t-tests and repeated measures analyses. Results Arm symptoms were significantly more bothersome for SNAD compared with SNR patients at 6 months (mean, 4.8 v 3.0; P < .001) and at 12 months (3.6 v 2.5; P = .006). Longitudinally, SNAD patients were more likely to experience ipsilateral arm and breast symptoms, restricted work and social activity, and impaired QOL (P ≤ .002 all items). From 12 to 36 months, fewer than 15% of either SNAD or SNR patients reported moderate or greater severity of any given symptom or activity limitation. Conclusion Arm morbidity was greater with SNAD than with SNR. Despite considerable fears about complications from AD for breast cancer, this study demonstrates that initial problems with either surgery resolve over time. PMID:20679600

LEVEL III ECOREGION:ECOREGIONS FOR THE MAIA STUDY REGION

EPA Science Inventory

This data set is a geographic information system (GIS) coverage of aquatic ecoregions for the US Environmental Protection Agency (EPA) Mid-Atlantic Integrated Assessment (MAIA) Project. This coverage was produced from the USEPA Omernik Level III Ecoregions of the Conterminous U...

Ultrasonic irradiation enhanced the ability of Fluorescein-DA-Fe(III) on sonodynamic and sonocatalytic damages of DNA molecules.

PubMed

Wu, Qiong; Chen, Xia; Jia, Lizhen; Wang, Yi; Sun, Ying; Huang, Xingjun; Shen, Yuxiang; Wang, Jun

2017-11-01

The interaction of DNA with Bis [N,N-bis (carboxymethyl) aminomethyl] fluorescein-Ferrous(III) (Fluorescein-DA-Fe(III)) with dual functional (sonodynamic and sonocatalytic) activity was studied by UV-vis spectroscopy, fluorescence spectroscopy, FT-IR spectroscopy, circular dichroism (CD) spectroscopy and viscosity measurements. And then, the damage of DNA caused by Fluorescein-DA-Fe(III) under ultrasonic irradiation (US) was researched by agarose gel electrophoresis and cytotoxicity assay. Meanwhile, some influenced factors such as ultrasonic irradiation time and Fluorescein-DA-Fe(III) concentration on the damage degree of DNA molecules were also examined. As a control, for Bis [N,N-bis (carboxymethyl) aminomethyl] fluorescein (Fluorescein-DA), the same experiments were carried out. The results showed that both Fluorescein-DA-Fe(III) and Fluorescein-DA can interact with DNA molecules. Under ultrasonic irradiation, Fluorescein-DA shows sonodynamic activity, which can damage DNA molecules. While, in the presence of Fe(III) ion, the Fluorescein-DA-Fe(III) displays not only sonodynamic activity but also sonocatalytic activity under ultrasonic irradiation, which injures DNA more serious than Fluorescein-DA. The researches confirmed the dual function (sonodynamic activity and sonocatalytic activity) of Fluorescein-DA-Fe(III) and expanded the usage of Fluorescein-DA-Fe(III) as a sonosensitizer in sonodynamic therapy (SDT). Copyright © 2017 Elsevier B.V. All rights reserved.

5-HT3A -driven green fluorescent protein delineates gustatory fibers innervating sour-responsive taste cells: A labeled line for sour taste?

PubMed

Stratford, J M; Larson, E D; Yang, R; Salcedo, E; Finger, T E

2017-07-01

Taste buds contain multiple cell types with each type expressing receptors and transduction components for a subset of taste qualities. The sour sensing cells, Type III cells, release serotonin (5-HT) in response to the presence of sour (acidic) tastants and this released 5-HT activates 5-HT 3 receptors on the gustatory nerves. We show here, using 5-HT 3A GFP mice, that 5-HT 3 -expressing nerve fibers preferentially contact and receive synaptic contact from Type III taste cells. Further, these 5-HT 3 -expressing nerve fibers terminate in a restricted central-lateral portion of the nucleus of the solitary tract (nTS)-the same area that shows increased c-Fos expression upon presentation of a sour tastant (30 mM citric acid). This acid stimulation also evokes c-Fos in the laterally adjacent mediodorsal spinal trigeminal nucleus (DMSp5), but this trigeminal activation is not associated with the presence of 5-HT 3 -expressing nerve fibers as it is in the nTS. Rather, the neuronal activation in the trigeminal complex likely is attributable to direct depolarization of acid-sensitive trigeminal nerve fibers, for example, polymodal nociceptors, rather than through taste buds. Taken together, these findings suggest that transmission of sour taste information involves communication between Type III taste cells and 5-HT 3 -expressing afferent nerve fibers that project to a restricted portion of the nTS consistent with a crude mapping of taste quality information in the primary gustatory nucleus. © 2017 Wiley Periodicals, Inc.

High temperature process steam application at the Southern Union Refining Company, Hobbs, New Mexico. Solar energy in the oil patch. Final report, Phase III: operation, maintenance, and performance

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wilson, L.E.; McGuire, D.R.

1984-05-01

This final report summarizes the technical reports for Phase III of this project. The third phase included the operation, maintenance, upgrade and performance reporting of a 10,080 square foot Solar Industrial Process Heat System installed at the Famariss Energy Refinery of Southern Union Refining Company near Hobbs, New Mexico. This report contains a description of the upgraded system, and a summary of the overall operation, maintenance and performance of the installed system. The results of the upgrade activities can be seen in the last two months of operational data. Steam production was significantly greater in peak flow and monthly totalmore » than at any previous time. Also monthly total cost savings was greatly improved even though natural gas costs remain much lower than originally anticipated.« less

As(III) oxidation by active chlorine and subsequent removal of As(V) by Al13 polymer coagulation using a novel dual function reagent.

PubMed

Hu, Chengzhi; Liu, Huijuan; Chen, Guixia; Jefferson, William A; Qu, Jiuhui

2012-06-19

An electrochemically prepared water treatment reagent containing a high concentration of Al(13) polymer and active chlorine (PACC) showed promising potential for the removal of As(III) due to the combined function of oxidation and coagulation. The results indicated that PACC was effective for As(III) removal through oxidation by the active chlorine and subsequent removal of As(V) by coagulation with the Al(13) polymer. The As(III) was oxidized to As(V) by active chlorine in PACC, with a stoichiometric rate of 0.99 mg Cl(2)/mg As(III). The Al(13) polymer was the most active Al species responsible for As(V) removal in PACC. To meet As drinking water standards the stoichiometric weight ratio of Cl(2)/Al within PACC was 0.09 for the treatment of As(III). Considering the process of As(III) oxidation and As(V) coagulation together, the optimal pH conditions for the removal of As by PACC was within the neutral range, which facilitated the reaction of As(III) with active chlorine and favored the formation of Al hydroxide flocs. The presence of humic acid reduced the As(III) removal efficiency of PACC due to its negative influence on subsequent As(V) coagulation, and disinfection byproduct yields were very low in the presence of insufficient or stoichiometric active chlorine.

Assessment Of The Effect Of Participation In Zooniverse Projects On Content Knowledge

NASA Astrophysics Data System (ADS)

Cormier, Sebastien; Prather, E. E.; Brissenden, G.; Lintott, C.; Gay, P. L.; Raddick, J.; Collaboration of Astronomy Teaching Scholars CATS

2011-01-01

The citizen science projects developed by Zooniverse afford volunteers the opportunity to contribute to scientific research in a meaningful way by interacting with actual scientific data. We created two surveys to measure the impact that participation in the Galaxy Zoo and Moon Zoo citizen science projects has on user conceptual knowledge. The Zooniverse Astronomy Concept Survey (ZACS) was designed to assess Galaxy Zoo user understanding of concepts related to galaxies and how their understanding changed through participation in classifying galaxies. The Lunar Cratering Concept Inventory (LCCI) was designed to measure the impact of the Moon Zoo activities on user knowledge about lunar craters and cratering history. We describe how the surveys were developed and validated in collaboration with education researchers and astronomers. Both instruments are administered over time to measure changes to user conceptual knowledge as they gain experience with either Galaxy Zoo or Moon Zoo. Data collection has already begun and in the future we will be able to compare survey answers from users who have classified, for example, a thousand galaxies with users who have only classified ten galaxies. This material is based upon work supported by the National Science Foundation under Grant No. 0715517, a CCLI Phase III Grant for the Collaboration of Astronomy Teaching Scholars (CATS). Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the National Science Foundation and the Sloan Digital Sky Survey III Education and Public Outreach Program.

Aids to navigation service force mix 2000 project. Volume 3 : analysis of multi-mission requirements and development of planning factors for the replacement buoy tender fleet

DOT National Transportation Integrated Search

1992-06-01

The Aids to Navigation (ATON) Service Force Mix (SFM) 2000 Project is documented in a Project Overview and three separately bound volumes. This is Volume III. The Project Overview describes the purpose, approach, analysis, and results of the ATON SFM...

Polymerase III transcription factor B activity is reduced in extracts of growth-restricted cells.

PubMed Central

Tower, J; Sollner-Webb, B

1988-01-01

Extracts of cells that are down-regulated for transcription by RNA polymerase I and RNA polymerase III exhibit a reduced in vitro transcriptional capacity. We have recently demonstrated that the down-regulation of polymerase I transcription in extracts of cycloheximide-treated and stationary-phase cells results from a lack of an activated subform of RNA polymerase I which is essential for rDNA transcription. To examine whether polymerase III transcriptional down-regulation occurs by a similar mechanism, the polymerase III transcription factors were isolated and added singly and in pairs to control cell extracts and to extracts of cells that had reduced polymerase III transcriptional activity due to cycloheximide treatment or growth into stationary phase. These down-regulations result from a specific reduction in TFIIIB; TFIIIC and polymerase III activities remain relatively constant. Thus, although transcription by both polymerase III and polymerase I is substantially decreased in extracts of growth-arrested cells, this regulation is brought about by reduction of different kinds of activities: a component of the polymerase III stable transcription complex in the former case and the activated subform of RNA polymerase I in the latter. Images PMID:3352599

Advanced reservoir characterization and evaluation of CO{sub 2} gravity drainage in the naturally fractured Spraberry Trend Area, Class III

DOE Office of Scientific and Technical Information (OSTI.GOV)

Heckman, Tracy; Schechter, David S.

2000-04-11

The overall goal of this project was to assess the economic feasibility of CO{sub 2} flooding the naturally fractured Spraberry Trend Area in West Texas. This objective was accomplished by conducting research in four areas: (1) extensive characterization of the reservoirs, (2) experimental studies of crude oil/brine/rock (COBR) interaction in the reservoirs, (3) analytical and numerical simulation of Spraberry reservoirs, and, (4) experimental investigations on CO{sub 2} gravity drainage in Spraberry whole cores. This report provides results of the fourth year of the five-year project for each of the four areas including a status report of field activities leading upmore » to injection of CO{sub 2}.« less

Applying robotics to HAZMAT

NASA Technical Reports Server (NTRS)

Welch, Richard V.; Edmonds, Gary O.

1994-01-01

The use of robotics in situations involving hazardous materials can significantly reduce the risk of human injuries. The Emergency Response Robotics Project, which began in October 1990 at the Jet Propulsion Laboratory, is developing a teleoperated mobile robot allowing HAZMAT (hazardous materials) teams to remotely respond to incidents involving hazardous materials. The current robot, called HAZBOT III, can assist in locating characterizing, identifying, and mitigating hazardous material incidents without risking entry team personnel. The active involvement of the JPL Fire Department HAZMAT team has been vital in developing a robotic system which enables them to perform remote reconnaissance of a HAZMAT incident site. This paper provides a brief review of the history of the project, discusses the current system in detail, and presents other areas in which robotics can be applied removing people from hazardous environments/operations.

Overview of Edge Simulation Laboratory (ESL)

NASA Astrophysics Data System (ADS)

Cohen, R. H.; Dorr, M.; Hittinger, J.; Rognlien, T.; Umansky, M.; Xiong, A.; Xu, X.; Belli, E.; Candy, J.; Snyder, P.; Colella, P.; Martin, D.; Sternberg, T.; van Straalen, B.; Bodi, K.; Krasheninnikov, S.

2006-10-01

The ESL is a new collaboration to build a full-f electromagnetic gyrokinetic code for tokamak edge plasmas using continuum methods. Target applications are edge turbulence and transport (neoclassical and anomalous), and edge-localized modes. Initially the project has three major threads: (i) verification and validation of TEMPEST, the project's initial (electrostatic) edge code which can be run in 4D (neoclassical and transport-timescale applications) or 5D (turbulence); (ii) design of the next generation code, which will include more complete physics (electromagnetics, fluid equation option, improved collisions) and advanced numerics (fully conservative, high-order discretization, mapped multiblock grids, adaptivity), and (iii) rapid-prototype codes to explore the issues attached to solving fully nonlinear gyrokinetics with steep radial gradiens. We present a brief summary of the status of each of these activities.

Progress Report of the Schools Television Research Project--III

ERIC Educational Resources Information Center

Kemelfield, Graeme

1969-01-01

"This concluding article provides the first published account of a series of psychological experiments which are presently being undertaken by the Schools Television Research Project, examining presentation factors in instructional television. (Editor)

34 CFR 611.32 - What are the program's general selection criteria?

Code of Federal Regulations, 2012 CFR

2012-07-01

... provided by the school of arts and sciences; (iii) Includes well-designed academic and student support... those who would implement the project have important roles in project design, implementation, governance...

34 CFR 611.32 - What are the program's general selection criteria?

Code of Federal Regulations, 2013 CFR

2013-07-01

... provided by the school of arts and sciences; (iii) Includes well-designed academic and student support... those who would implement the project have important roles in project design, implementation, governance...

34 CFR 611.32 - What are the program's general selection criteria?

Code of Federal Regulations, 2014 CFR

2014-07-01

... provided by the school of arts and sciences; (iii) Includes well-designed academic and student support... those who would implement the project have important roles in project design, implementation, governance...

48 CFR 570.105-2 - Two-phase design-build selection procedures.

Code of Federal Regulations, 2010 CFR

2010-10-01

... lease construction projects with options to purchase the real property leased. Use the procedures in.... (iii) The capability and experience of potential contractors. (iv) The suitability of the project for...

VizieR Online Data Catalog: OGLE-III. Magellanic Clouds stellar proper motions (Poleski+, 2012)

NASA Astrophysics Data System (ADS)

Poleski, R.; Soszynski, I.; Udalski, A.; Szymanski, M. K.; Kubiak, M.; Pietrzynski, G.; Wyrzykowski, L.; Ulaczyk, K.

2012-06-01

The OGLE-III project observed the MCs between 2001 and 2009 with 1.3-m Warsaw telescope, which is situated at the Las Campanas Observatory, Chile. The observatory is operated by the Carnegie Institution for Science. (4 data files).

Performance modeling for large database systems

NASA Astrophysics Data System (ADS)

Schaar, Stephen; Hum, Frank; Romano, Joe

1997-02-01

One of the unique approaches Science Applications International Corporation took to meet performance requirements was to start the modeling effort during the proposal phase of the Interstate Identification Index/Federal Bureau of Investigations (III/FBI) project. The III/FBI Performance Model uses analytical modeling techniques to represent the III/FBI system. Inputs to the model include workloads for each transaction type, record size for each record type, number of records for each file, hardware envelope characteristics, engineering margins and estimates for software instructions, memory, and I/O for each transaction type. The model uses queuing theory to calculate the average transaction queue length. The model calculates a response time and the resources needed for each transaction type. Outputs of the model include the total resources needed for the system, a hardware configuration, and projected inherent and operational availability. The III/FBI Performance Model is used to evaluate what-if scenarios and allows a rapid response to engineering change proposals and technical enhancements.

The role of hyperglycaemia-induced alterations of antithrombin III and factor X activation in the thrombin hyperactivity of diabetes mellitus.

PubMed

Ceriello, A; Quatraro, A; Marchi, E; Barbanti, M; Dello Russo, P; Lefebvre, P; Giugliano, D

1990-05-01

Factor X concentration and factor X activation, antithrombin III anti-Xa activity and plasma concentration, and fibrinopeptide A were measured in 20 diabetic patients and 20 normal subjects. Although factor X activation (81.3 +/- 2.2 vs 97.3 +/- 2.1%, p less than 0.01; mean +/- SE) and antithrombin III activity (76.5 +/- 2.2 vs 96.3 +/- 1.8%, p less than 0.01) were reduced in the diabetic patients, fibrinopeptide A concentration was increased (3.7 +/- 0.4 vs 1.7 +/- 0.2 ng ml-1, p less than 0.01). The ratio of factor X activation to antithrombin III anti-factor Xa activity was increased in the diabetic patients (1.10 +/- 0.01 vs 1.01 +/- 0.02, p less than 0.01). Induced hyperglycaemia was able to mimic all these abnormalities, without changing factor X or antithrombin III concentration. The results suggest that in vivo hyperglycaemia produces a decrease of factor X activation, but at the same time increases fibrinopeptide A formation due to a greater decrease of antithrombin III anti-Xa activity.

Oregon regional intelligent transportation systems (ITS) integration program. Final phase III report, I-5/Barbur Boulevard Parallel Corridor Traffic Management Demonstration Project

DOT National Transportation Integrated Search

2005-07-01

This report presents the results of the evaluation of the I-5/Barbur Boulevard Parallel Corridor Traffic Management Demonstration Project, a cooperative project between the Oregon Department of Transportation (ODOT) and the City of Portland to integr...

36 CFR 801.7 - Information requirements.

Code of Federal Regulations, 2010 CFR

2010-07-01

... project; (ii) A description of the proposed project including, as appropriate, photographs, maps, drawings... Criteria exist in the project area, or a brief statement explaining why the Criteria of Effect (See § 801.3... appropriate, photographs, maps, drawings and specifications; (iii) A copy of the National Register form or a...

A Communication Skills Program Model. Rural Isolated Schools Program.

ERIC Educational Resources Information Center

Southeastern Education Lab., Atlanta, GA.

Contents of this report on a fictitiously named (Harold County) project, prepared as a guide in applying for Title III ESEA funding consideration, are in five parts. Part I projects basic ESEA statistical information, including budget, school enrollment, project participation, staff members engaged, personnel for administration and implementation…

GBM heterogeneity as a function of variable epidermal growth factor receptor variant III activity.

PubMed

Lindberg, Olle R; McKinney, Andrew; Engler, Jane R; Koshkakaryan, Gayane; Gong, Henry; Robinson, Aaron E; Ewald, Andrew J; Huillard, Emmanuelle; David James, C; Molinaro, Annette M; Shieh, Joseph T; Phillips, Joanna J

2016-11-29

Abnormal activation of the epidermal growth factor receptor (EGFR) due to a deletion of exons 2-7 of EGFR (EGFRvIII) is a common alteration in glioblastoma (GBM). While this alteration can drive gliomagenesis, tumors harboring EGFRvIII are heterogeneous. To investigate the role for EGFRvIII activation in tumor phenotype we used a neural progenitor cell-based murine model of GBM driven by EGFR signaling and generated tumor progenitor cells with high and low EGFRvIII activation, pEGFRHi and pEGFRLo. In vivo, ex vivo, and in vitro studies suggested a direct association between EGFRvIII activity and increased tumor cell proliferation, decreased tumor cell adhesion to the extracellular matrix, and altered progenitor cell phenotype. Time-lapse confocal imaging of tumor cells in brain slice cultures demonstrated blood vessel co-option by tumor cells and highlighted differences in invasive pattern. Inhibition of EGFR signaling in pEGFRHi promoted cell differentiation and increased cell-matrix adhesion. Conversely, increased EGFRvIII activation in pEGFRLo reduced cell-matrix adhesion. Our study using a murine model for GBM driven by a single genetic driver, suggests differences in EGFR activation contribute to tumor heterogeneity and aggressiveness.

Evaluation of "Autosense-III" laser detection technology for traffic applications on I-4

DOT National Transportation Integrated Search

2001-11-01

The major tasks of this project include procuring the two AUTOSENSE III units; selecting a site on I-4 for installation of the units, installing the units successfully on I-4, establishing a remote communication link through cellular data line to dow...

48 CFR 52.234-1 - Industrial Resources Developed Under Defense Production Act Title III.

Code of Federal Regulations, 2011 CFR

2011-10-01

... materials, services, processes, or manufacturing equipment (including the processes, technologies, and... project contractor for testing and qualification of a Title III industrial resource to the Contracting... Contracting Officer modifies the contract to direct testing pursuant to this clause, the Government will...

Stability of the Osmoregulated Promoter-Derived proP mRNA Is Posttranscriptionally Regulated by RNase III in Escherichia coli

PubMed Central

Lim, Boram

2015-01-01

ABSTRACT The enzymatic activity of Escherichia coli endo-RNase III determines the stability of a subgroup of mRNA species, including bdm, betT, and proU, whose protein products are associated with the cellular response to osmotic stress. Here, we report that the stability of proP mRNA, which encodes a transporter of osmoprotectants, is controlled by RNase III in response to osmotic stress. We observed that steady-state levels of proP mRNA and ProP protein are inversely correlated with cellular RNase III activity and, in turn, affect the proline uptake capacity of the cell. In vitro and in vivo analyses of proP mRNA revealed RNase III cleavage sites in a stem-loop within the 5′ untranslated region present only in proP mRNA species synthesized from the osmoregulated P1 promoter. Introduction of nucleotide substitutions in the cleavage site identified inhibited the ribonucleolytic activity of RNase III on proP mRNA, increasing the steady-state levels and half-life of the mRNA. In addition, decreased RNase III activity coincided with a significant increase in both the half-life and abundance of proP mRNA under hyperosmotic stress conditions. Analysis of the RNA bound to RNase III via in vivo cross-linking and immunoprecipitation indicated that this phenomenon is related to the decreased RNA binding capacity of RNase III. Our findings suggest the existence of an RNase III-mediated osmoregulatory network that rapidly balances the expression levels of factors associated with the cellular response to osmotic stress in E. coli. IMPORTANCE Our results demonstrate that RNase III activity on proP mRNA degradation is downregulated in Escherichia coli cells under osmotic stress. In addition, we show that the downregulation of RNase III activity is associated with decreased RNA binding capacity of RNase III under hyperosmotic conditions. In particular, our findings demonstrate a link between osmotic stress and RNase III activity, underscoring the growing importance of posttranscriptional regulation in modulating rapid physiological adjustment to environmental changes. PMID:25645556

Decommissioning of the TRIGA mark II and III and radioactive waste management

DOE Office of Scientific and Technical Information (OSTI.GOV)

Doo Seong Hwang; Yoon Ji Lee; Gyeong Hwan Chung

2013-07-01

KAERI has carried out decommissioning projects for two research reactors (KRR-1 and 2). The decommissioning project of KRR-1 (TRIGA Mark II) and 2 (TRIGA Mark III) was launched in 1997 with a total budget of 23.25 million US dollars. KRR-2 and all auxiliary facilities were already decommissioned, and KRR-1 is being decommissioned now. Much more dismantled waste is generated than in any other operations of nuclear facilities. Thus, the waste needs to be reduced and stabilized through decontamination or treatment before disposal. This paper introduces the current status of the decommissioning projects and describes the volume reduction and conditioning ofmore » decommissioning waste for final disposal. (authors)« less

Project CHECO Southeast Asia Report. Project RED HORSE

DTIC Science & Technology

1969-09-01

It 0,Il 1IC1I lll Examination of C’urrentI,,,,,,,,[ I prations IIR / IE IP𔃻 0 R IT - PROJECT RED HORSE 1 SEPTEMBER 1969 HQ PACAF Directorate...3 CHAPTER II RED HORSE ORGANIZATIONS IN SOUTHEAST ASIA .................. 5 Introduction...RED HORSE Combat Defense Teams....................... ...... 59 III. 555th CES (HR) Projects...................................... 62 IV. 820th CES

The fusion of gerontology and technology in nursing education: History and demonstration of the Gerontological Informatics Reasoning Project--GRIP.

PubMed

Dreher, H Michael; Cornelius, Fran; Draper, Judy; Pitkar, Harshad; Manco, Janet; Song, Il-Yeol

2006-01-01

Phase I of our Gerontological Reasoning Informatics Project (GRIP) began in the summer of 2002 when all 37 senior undergraduate nursing students in our accelerated BSN nursing program were given PDAs. These students were oriented to use a digitalized geriatric nursing assessment tool embedded into their PDA in a variety of geriatric clinical agencies. This informatics project was developed to make geriatric nursing more technology oriented and focused on seven modules of geriatric assessment: intellect (I), nutrition (N), self-concept (S), physical activity (P), interpersonal functioning (I), restful sleep (R), and elimination (E)--INSPIRE. Through phase II and now phase III, the GRIP Project has become a major collaboration between the College of Nursing & Health Professions and College of Information Science and Technology at Drexel University. The digitalized geriatric nursing health assessment tool has undergone a second round of reliability and validity testing and is now used to conduct a 20 minute comprehensive geriatric health assessment on the PDA, making our undergraduate gerontology course the most high tech clinical course in our nursing curriculum.

Structure-activity studies of lGnRH-III through rational amino acid substitution and NMR conformational studies.

PubMed

Pappa, Eleni V; Zompra, Aikaterini A; Diamantopoulou, Zoi; Spyranti, Zinovia; Pairas, George; Lamari, Fotini N; Katsoris, Panagiotis; Spyroulias, George A; Cordopatis, Paul

2012-01-01

Lamprey gonadotropin-releasing hormone type III (lGnRH-III) is an isoform of GnRH isolated from the sea lamprey (Petromyzon marinus) with negligible endocrine activity in mammalian systems. Data concerning the superior direct anticancer activity of lGnRH-III have been published, raising questions on the structure-activity relationship. We synthesized 21 lGnRH-III analogs with rational amino acid substitutions and studied their effect on PC3 and LNCaP prostate cancer cell proliferation. Our results question the importance of the acidic charge of Asp⁶ for the antiproliferative activity and indicate the significance of the stereochemistry of Trp in positions 3 and 7. Furthermore, conjugation of an acetyl-group to the side chain of Lys⁸ or side chain cyclization of amino acids 1-8 increased the antiproliferative activity of lGnRH-III demonstrating that the proposed salt bridge between Asp⁶ and Lys⁸ is not crucial. Conformational studies of lGnRH-III were performed through NMR spectroscopy, and the solution structure of GnRH-I was solved. In solution, lGnRH-III adopts an extended backbone conformation in contrast to the well-defined β-turn conformation of GnRH-I. Copyright © 2012 Wiley Periodicals, Inc.

77 FR 20637 - Agency Information Collection Activities; Proposed Collection; Comment Request; OAA Title III-C...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-05

... Activities; Proposed Collection; Comment Request; OAA Title III-C Evaluation AGENCY: Administration on Aging... on the information collection requirements relating to OAA Title III-C Evaluation DATES: Submit... caring for grandchildren, who are essential to making community living possible. The OAA Title III-C...

Enhanced Night Visibility Series, Volume XII : Overview of Phase II and Development of Phase III Experimental Plan

DOT National Transportation Integrated Search

2005-12-01

This volume provides an overview of the six studies that compose Phase II of the Enhanced Night Visibility project and the experimental plan for its third and final portion, Phase III. The Phase II studies evaluated up to 12 vision enhancement system...

78 FR 18325 - Defense Transportation Regulation, Part IV

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2013-03-26

... received in connection with the Defense Personal Property Program (DP3) Phase III Direct Procurement Method... at http://www.transcom.mil/dtr/part-iv/phaseiii.cfm (DPM SECTION). All identified changes will be... Defense Personal Property System (DPS) Phase III programming projected for FY17. FOR FURTHER INFORMATION...

76 FR 36095 - Defense Transportation Regulation, Part IV

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-21

... with the Defense Personal Property Program (DP3) Phase III Domestic Small Shipments (dS2) and... Regulation, Part IV Web site at http://www.transcom.mil/dtr/part-iv/phaseiii.cfm . All identified changes... based on completion of Defense Personal Property System (DPS) Phase III programming projected for FY15...

76 FR 56748 - Combined Notice of Filings #2

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-14

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 Take notice...)(2)(iii: Amend Standard LGIA Desert Sunlight Project to be effective 9/7/2011. Filed Date: 09/06/2011...: Wabash Valley Power Association, Inc. submits tariff filing per 35.13(a)(2)(iii: Amendment to add MISO...

Research Staff | Chemistry and Nanoscience Research | NREL

Science.gov Websites

Jeffrey Blackburn Jeffrey Blackburn Group Research Manager III-Materials Science Dr. Blackburn is a Senior Scientist and Group Manager at NREL, leading projects on a variety of fundamental and applied research -Electrical Engineering Guido.Bender@nrel.gov 303-275-3810 Blackburn, Jeffrey Group Research Manager III

24 CFR 201.10 - Loan amounts.

Code of Federal Regulations, 2014 CFR

2014-04-01

... actual cost of the project plus any applicable fees and charges authorized at § 201.25(b), up to the... property improvement loans—$60,000 or an average of $12,000 per dwelling unit, whichever is less. (iii... detailed in the manufacturer's invoice; (iii) The actual dealer's cost of transportation to the homesite...

Sonic Hedgehog Expression in Corticofugal Projection Neurons Directs Cortical Microcircuit Formation

PubMed Central

Harwell, Corey C.; Parker, Philip R.L.; Gee, Steven M.; Okada, Ami; McConnell, Susan K.; Kreitzer, Anatol C.; Kriegstein, Arnold R.

2012-01-01

SUMMARY The precise connectivity of inputs and outputs is critical for cerebral cortex function; however, the cellular mechanisms that establish these connections are poorly understood. Here, we show that the secreted molecule Sonic Hedgehog (Shh) is involved in synapse formation of a specific cortical circuit. Shh is expressed in layer V corticofugal projection neurons and the Shh receptor, Brother of CDO (Boc), is expressed in local and callosal projection neurons of layer II/III that synapse onto the subcortical projection neurons. Layer V neurons of mice lacking functional Shh exhibit decreased synapses. Conversely, the loss of functional Boc leads to a reduction in the strength of synaptic connections onto layer Vb, but not layer II/III, pyramidal neurons. These results demonstrate that Shh is expressed in postsynaptic target cells while Boc is expressed in a complementary population of presynaptic input neurons, and they function to guide the formation of cortical microcircuitry. PMID:22445340

Effects of Pop III to PopII transition on the lowest metallicity stars in dwarf galaxies

NASA Astrophysics Data System (ADS)

Zhang, Yimiao; Keres, Dusan; FIRE Team

2018-01-01

We examine the effects of the enrichments from Population III (Pop III) stars on the formation and properties of the first generation of the Population II (Pop II) stars. Pop III stars begin to transition towards Pop II stars when the metals dispersed in Pop III supernovae pollute the nearby gas. However, details of this transition are still largely unknown. We use dwarf galaxy simulations from the Feedback In Realistic Environments (FIRE) project to identify the star-forming gas that is likely to be pre-enriched by Pop III supernovae and follow the stars that form in such gas. This pre-enrichment will leave the signature in the lowest metallicity stars that can be used to better constrain the details of the Pop III-to-Pop II transition.

Impact assessment of a maternal health project in a megacity, Nigeria: toward a future with more demand for maternal health services.

PubMed

Matsuoka, Sadatoshi; Koga, Sumiko; Suzui, Emiko; Tsukada, Yoshiko; Ohashi, Kazutomo; Johnson, Taiwo

2017-10-01

To improve the quantity and quality of maternal health services in Lagos State, Nigeria having a maternal mortality ratio of 555 per 100 000 live births, a four-year project was implemented since February 2010. The major activity of the project was training for both the service supply and demand sides. This study aimed to examine the impact of the project on coverages and quality of the services in target areas, and guide statewide policies. The Cochran-Armitage test for trend was applied to understand trends in the service coverages during 2009-2013. The same test was performed to analyse trends in the proportions of perineal conditions (i.e. intact or tear) and to evaluate variations in midwives' snkill during 2011-2013. The paired t-test was used to analyse changes in midwives' knowledge. The project interventions contributed to a significant increase in the overall service coverages, including improvements in midwifery knowledge and possibly in their skills. However, the service coverage was still limited as of the termination of the project. To instal the interventions and maximise the effect of them state-wide, it is recommended to undertake five tasks: (i) establishment of public primary health centres offering 24-h maternal health services; (ii) redeployment and recruitment of public health personnel; (iii) expansion of midwifery trainings and continuous education by the local trainers; (iv) review of grass-roots level activities; and (v) scrutiny of barriers to maternal health services. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

78 FR 61996 - Combined Notice of Filings #1

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-10

.../13. Docket Numbers: ER13-2474-000. Applicants: Steele Flats Wind Project, LLC. Description: Steele Flats Wind Project, LLC submits Steele Flats Wind Project, LLC Application for Market-Based Rates to be... Energy Florida, Inc. submits tariff filing per 35.13(a)(2)(iii: OATT Name Change to be effective 7/3/2012...

24 CFR 5.661 - Section 8 project-based assistance programs: Approval for police or other security personnel to...

Code of Federal Regulations, 2010 CFR

2010-04-01

.... (iii) Full disclosure of any family relationship between the owner and any security personnel. For this... with Disabilities: Family Income and Family Payment; Occupancy Requirements for Section 8 Project-Based... 8 families residing in the project. (2) The owner's application must include the following...

Final evaluation Report, 1975-76. ESAA III Pilot Project Assist.

ERIC Educational Resources Information Center

Austin Independent School District, TX. Office of Research and Evaluation.

This evaluation report is presented at the conclusion of the third year of Project Assist, a program funded under the Emergency School Assistant Act (ESAA). The main focus of the project was on improving student reading and mathematics skills primarily through contact with instructional teacher aides and special supplementary instructional…

Mathematics: PROJECT DESIGN. Educational Needs, Fresno, 1968, Number 12.

ERIC Educational Resources Information Center

Smart, James R.

This report examines and summarizes the needs in mathematics of the Fresno City school system. The study is one in a series of needs assessment reports for PROJECT DESIGN, an ESEA Title III project administered by the Fresno City Unified School District. Theoretical concepts, rather than computational drill, would be emphasized in the proposed…

National evaluation of the FY 2003 Earmarked ITS Integration Project : Southern Wyoming, I-80 dynamic message signs, final phase III evaluation report.

DOT National Transportation Integrated Search

2010-12-01

This report presents the results for the national evaluation of the FY 2003 Earmarked ITS Integration Project: Southern Wyoming, I-80 Dynamic Message Signs. The I-80 Dynamic Message Signs project is a rural infrastructure deployment of ITS devices th...

77 FR 51032 - National Cancer Institute; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-23

... personal privacy. Name of Committee: National Cancer Institute Special Emphasis Panel, NCI Program Project... Cancer Institute Special Emphasis Panel, NCI Program Project Meeting III. Date: October 10-11, 2012. Time... Project Meeting IV. Date: October 15-16, 2012. Time: 8:00 a.m. to 5:00 p.m. Agenda: To review and evaluate...

Technology Development of Miniaturized Far-Infrared Sources for Biomolecular Spectroscopy

NASA Technical Reports Server (NTRS)

Kono, Junichiro

2003-01-01

The objective of this project was to develop a purely solid-state based, thus miniaturized, far-infrared (FIR) (also known as terahertz (THz)) wave source using III-V semiconductor nanostructures for biomolecular detection and sensing. Many biomolecules, such as DNA and proteins, have distinct spectroscopic features in the FIR wavelength range as a result of vibration-rotation-tunneling motions and various inter- and intra-molecule collective motions. Spectroscopic characterization of such molecules requires narrow linewidth, sufficiently high power, tunable (in wavelength), and coherent FIR sources. Unfortunately, the FIR frequency is one of the least technologically developed ranges in the electromagnetic spectrum. Currently available FIR sources based on non-solid state technology are bulky, inefficient, and very often incoherent. In this project we investigated antimonide based compound semiconductor (ABCS) nanostructures as the active medium to generate FIR radiation. The final goal of this project was to demonstrate a semiconductor THz source integrated with a pumping diode laser module to achieve a compact system for biomolecular applications.

Two Orangutan Species Have Evolved Different KIR Alleles and Haplotypes1

PubMed Central

Guethlein, Lisbeth A.; Norman, Paul J.; Heijmans, Corinne M. C.; de Groot, Natasja G.; Hilton, Hugo G.; Babrzadeh, Farbod; Abi-Rached, Laurent; Bontrop, Ronald E.; Parham, Peter

2017-01-01

The immune and reproductive functions of human Natural Killer (NK) cells are regulated by interactions of the C1 and C2 epitopes of HLA-C with C1-specific and C2-specific lineage III killer cell immunoglobulin-like receptors (KIR). This rapidly evolving and diverse system of ligands and receptors is restricted to humans and great apes. In this context, the orangutan has particular relevance because it represents an evolutionary intermediate, one having the C1 epitope and corresponding KIR, but lacking the C2 epitope. Through a combination of direct sequencing, KIR genotyping and data mining from the Great Ape Genome Project (GAGP) we characterized the KIR alleles and haplotypes for panels of ten Bornean orangutans and 19 Sumatran orangutans. The orangutan KIR haplotypes have between five and ten KIR genes. The seven orangutan lineage III KIR genes all locate to the centromeric region of the KIR locus, whereas their human counterparts also populate the telomeric region. One lineage III KIR gene is Bornean-specific, one is Sumatran-specific and five are shared. Of twelve KIR gene-content haplotypes five are Bornean-specific, five are Sumatran-specific and two are shared. The haplotypes have different combinations of genes encoding activating and inhibitory C1 receptors that can be of higher or lower affinity. All haplotypes encode an inhibitory C1 receptor, but only some haplotypes encode an activating C1 receptor. Of 130 KIR alleles, 55 are Bornean-specific, 65 are Sumatran specific and ten are shared. PMID:28264973

No evidence for [O III] variability in Mrk 142

NASA Astrophysics Data System (ADS)

Barth, Aaron J.; Bentz, Misty C.

2016-05-01

Using archival data from the 2008 Lick AGN Monitoring Project, Zhang & Feng claimed to find evidence for flux variations in the narrow [O III] emission of the Seyfert 1 galaxy Mrk 142 over a two-month time span. If correct, this would imply a surprisingly compact size for the narrow-line region. We show that the claimed [O III] variations are merely the result of random errors in the overall flux calibration of the spectra. The data do not provide any support for the hypothesis that the [O III] flux was variable during the 2008 monitoring period.

Activity status and future plans for the Optical Laboratory of the National Astronomical Research Institute of Thailand

NASA Astrophysics Data System (ADS)

Buisset, Christophe; Poshyachinda, Saran; Soonthornthum, Boonrucksar; Prasit, Apirat; Alagao, Mary Angelie; Choochalerm, Piyamas; Wanajaroen, Weerapot; Lepine, Thierry; Rabbia, Yves; Aukkaravittayapun, Suparerk; Leckngam, Apichat; Thummasorn, Griangsak; Ngernsujja, Surin; Inpan, Anuphong; Kaewsamoet, Pimon; Lhospice, Esther; Meemon, Panomsak; Artsang, Pornapa; Suwansukho, Kajpanya; Sirichote, Wichit; Paenoi, Jitsupa

2018-03-01

The National Astronomical Research Institute of Thailand (NARIT) has developed since June 2014 an optical laboratory that comprises all the activities and facilities related to the research and development of new instruments in the following areas: telescope design, high dynamic and high resolution imaging systems and spectrographs. The facilities include ZEMAX and Solidwork software for design and simulation activities as well as an optical room with all the equipment required to develop optical setup with cutting-edge performance. The current projects include: i) the development of a focal reducer for the 2.3 m Thai National Telescope (TNT), ii) the development of the Evanescent Wave Coronagraph dedicated to the high contrast observations of star close environment and iii) the development of low resolution spectrographs for the Thai National Telescope and for the 0.7 m telescopes of NARIT regional observatories. In each project, our activities start from the instrument optical and mechanical design to the simulation of the performance, the development of the prototype and finally to the final system integration, alignment and tests. Most of the mechanical parts are manufactured by using the facilities of NARIT precision mechanical workshop that includes a 3-axis Computer Numerical Control (CNC) to machine the mechanical structures and a Coordinate Measuring Machine (CMM) to verify the dimensions. In this paper, we give an overview of the optical laboratory activities and of the associated facilities. We also describe the objective of the current projects, present the specifications and the design of the instruments and establish the status of development and we present our future plans.

Handicapped Children's Nature Study Center: A Cooperative Project in Outdoor Education. End of Project Report.

ERIC Educational Resources Information Center

Lanaghan, David M.

Presented is the end of project report of the handicapped children's nature study center and outdoor education program (funded through Title III), a cooperative science/special education project serving approximately 1,000 children in the Muscatine-Scott County School System in Iowa. A 6 acre land strip bordered by a creek and a river is said to…

Design, synthesis, and herbicidal activity of novel substituted 3-(pyridin-2-yl)benzenesulfonamide derivatives.

PubMed

Xie, Yong; Chi, Hui-Wei; Guan, Ai-Ying; Liu, Chang-Ling; Ma, Hong-Juan; Cui, Dong-Liang

2014-12-31

A series of novel substituted 3-(pyridin-2-yl)benzenesulfonamide derivatives were designed and synthesized using 2-phenylpridines as the lead compound by intermediate derivatization methods in an attempt to obtain novel compound candidates for weed control. The herbicidal activity assay in glasshouse tests showed several compounds (II6, II7, II8, II9, II10, II11, III2, III3, III4, and III5) could efficiently control velvet leaf, youth-and-old age, barnyard grass, and foxtail at the 37.5 g/ha active substance. Especially, the activities of II6, II7, III2, and III4 were proved roughly equivalent to the saflufenacil and better than 95% sulcotrione at the same concentration. The result of the herbicidal activity assay in field tests demonstrated that II7 at 60 g/ha active substance could give the same effect as bentazon at 1440 g/ha active substance to control dayflower and nightshade, meanwhile II7 showed better activity than oxyfluorfen to control arrowhead and security to rice. The present work indicates that II7 may be a novel compound candidate for potential herbicide.

76 FR 36107 - Combined Notice of Filings #2

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-21

... Company submits tariff filing per 35.13(a)(2)(iii: WDT SGIA for CSUEB Fuel Cell Project to be effective 6... for CSUEB Fuel Cell Project to be effective 6/15/2011. Filed Date: 06/14/2011. Accession Number...

7 CFR 2.24 - Assistant Secretary for Administration.

Code of Federal Regulations, 2011 CFR

2011-01-01

... continue, modify, or terminate an information technology program or project. (iii) Provide advice and other... exchange, scheduling, computer conferencing, televideo technologies, and other applications of office... Chief Information Officers and agency major information technology system project managers in accordance...

7 CFR 2.24 - Assistant Secretary for Administration.

Code of Federal Regulations, 2012 CFR

2012-01-01

... continue, modify, or terminate an information technology program or project. (iii) Provide advice and other... exchange, scheduling, computer conferencing, televideo technologies, and other applications of office... Chief Information Officers and agency major information technology system project managers in accordance...

7 CFR 2.24 - Assistant Secretary for Administration.

Code of Federal Regulations, 2014 CFR

2014-01-01

... determining whether to continue, modify, or terminate an information technology program or project. (iii..., computer conferencing, televideo technologies, and other applications of office automation technology which... information technology system project managers in accordance with OMB policies. (D) Providing recommendations...

The International Permafrost Association: current initiatives for cryospheric research

NASA Astrophysics Data System (ADS)

Schollaen, Karina; Lewkowicz, Antoni G.; Christiansen, Hanne H.; Romanovsky, Vladimir E.; Lantuit, Hugues; Schrott, Lothar; Sergeev, Dimitry; Wei, Ma

2015-04-01

The International Permafrost Association (IPA), founded in 1983, has as its objectives to foster the dissemination of knowledge concerning permafrost and to promote cooperation among persons and national or international organizations engaged in scientific investigation and engineering work on permafrost. The IPA's primary responsibilities are convening International Permafrost Conferences, undertaking special projects such as preparing databases, maps, bibliographies, and glossaries, and coordinating international field programs and networks. Membership is through adhering national or multinational organizations or as individuals in countries where no Adhering Body exists. The IPA is governed by its Executive Committee and a Council consisting of representatives from 26 Adhering Bodies having interests in some aspect of theoretical, basic and applied frozen ground research, including permafrost, seasonal frost, artificial freezing and periglacial phenomena. This presentation details the IPA core products, achievements and activities as well as current projects in cryospheric research. One of the most important core products is the circumpolar permafrost map. The IPA also fosters and supports the activities of the Global Terrestrial Network on Permafrost (GTN-P) sponsored by the Global Terrestrial Observing System, GTOS, and the Global Climate Observing System, GCOS, whose long-term goal is to obtain a comprehensive view of the spatial structure, trends, and variability of changes in the active layer thickness and permafrost temperature. A further important initiative of the IPA are the biannually competitively-funded Action Groups which work towards the production of well-defined products over a period of two years. Current IPA Action Groups are working on highly topical and interdisciplinary issues, such as the development of a regional Palaeo-map of Permafrost in Eurasia, the integration of multidisciplinary knowledge about the use of thermokarst and permafrost landscapes, and defining permafrost research priorities - a roadmap for the future. The latter project is a joint effort with the Climate and Cryosphere initiative (CliC) and a contribution to the upcoming International Conference on Arctic Research Planning III (ICARP III). The product stemming from the effort will consist of a journal publication listing permafrost research priorities and putting them into context. In all of these activities, the IPA emphasizes the involvement of young researchers (especially through the Permafrost Young Researchers Network and APECS) as well as its collaboration with international partner organizations such as IASC, SCAR, CliC, IACS, IUGS and WMO.

[Long-term physical activity after a myocardial infarction : a permanent challenge].

PubMed

Tessitore, Elena; Sigaud, Philippe; Meyer, Philippe; Mach, François

2017-05-24

Cardiac rehabilitation is a well-defined multidisciplinary program with the objective to reduce mortality and morbidity, while also improving the exercise capacity and quality of life of the patient following a myocardial infarction. Despite the fact that a cardiovascular rehabilitation program is now recommended by international guidelines for all patients who have suffered from an acute coronary syndrome, only half of all patients actually participate to such a program in Switzerland. Even worse, especially when taking into consideration the population in Geneva, less than 5 % of patients follow a long-term cardiac maintenance program (phase III). Since 2015, our project has been to encourage patients who have completed a phase II cardiac rehabilitation program, to resume regular physical activity in the long term.

Low- and high-threshold primary afferent inputs to spinal lamina III antenna-type neurons.

PubMed

Fernandes, Elisabete C; Santos, Ines C; Kokai, Eva; Luz, Liliana L; Szucs, Peter; Safronov, Boris V

2018-06-21

and non-nociceptive sensory information. Antenna-type neurons with cell bodies located in lamina III and large dendritic trees extending from the superficial lamina I to deep lamina IV are best shaped for the integration of a wide variety of inputs arising from primary afferent fibers and intrinsic spinal circuitries. While the somatodendritic morphology, the hallmark of antenna neurons, has been well studied, little is still known about the axon structure and basic physiological properties of these cells. Here we did whole-cell recordings in a rat (P9-P12) spinal cord preparation with attached dorsal roots to examine the axon course, intrinsic firing properties and primary afferent inputs of antenna cells. Nine antenna cells were identified from a large sample of biocytin-filled lamina III neurons (n = 46). Axon of antenna cells showed intensive branching in laminae III-IV and, in half of the cases, issued dorsally directed collaterals reaching lamina I. Antenna cells exhibited tonic and rhythmic firing patterns; single spikes were followed by hyper- or depolarization. The neurons received monosynaptic inputs from the low-threshold Aβ afferents, Aδ afferents as well as from the high-threshold Aδ and C afferents. When selectively activated, C-fiber-driven mono- and polysynaptic EPSPs were sufficiently strong to evoke firing in the neurons. Thus, lamina III antenna neurons integrate low-threshold and nociceptive high-threshold primary afferent inputs, and can function as wide-dynamic-range neurons able to directly connect deep dorsal horn with the major nociceptive projection area lamina I.

Automated detection and tracking of solar and heliospheric features in the frame of the European project HELIO

NASA Astrophysics Data System (ADS)

Bonnin, X.; Aboudarham, J.; Fuller, N.; Renie, C.; Perez-Suarez, D.; Gallagher, P.; Higgins, P.; Krista, L.; Csillaghy, A.; Bentley, R.

2011-12-01

In the frame of the European project HELIO, the Observatoire de Paris-Meudon is in charge of the Heliophysics Feature Catalogue (HFC), a service which provides access to existing solar and heliospheric feature data. In order to create a catalogue as exhaustive as possible, recognition codes are developed to automatically detect and track features. At the time, HFC contains data of filaments, active regions, coronal holes, sunspots and type III radio bursts for a full solar cycle. The insertion of prominences and type II radio bursts should be done in the short term. We present here an overview of some of the algorithms used to populate HFC. The development of such fast and robust techniques also addresses the needs of the Space Weather community in terms of near real-time monitoring capabilities.

Synthesis, QSAR, and Molecular Dynamics Simulation of Amidino-substituted Benzimidazoles as Dipeptidyl Peptidase III Inhibitors.

PubMed

Rastija, Vesna; Agić, Dejan; Tomiš, Sanja; Nikolič, Sonja; Hranjec, Marijana; Grace, Karminski-Zamola; Abramić, Marija

2015-01-01

A molecular modeling study is performed on series of benzimidazol-based inhibitors of human dipeptidyl peptidase III (DPP III). An eight novel compounds were synthesized in excellent yields using green chemistry approach. This study is aimed to elucidate the structural features of benzimidazole derivatives required for antagonism of human DPP III activity using Quantitative Structure-Activity Relationship (QSAR) analysis, and to understand the mechanism of one of the most potent inhibitor binding into the active site of this enzyme, by molecular dynamics (MD) simulations. The best model obtained includes S3K and RDF045m descriptors which have explained 89.4 % of inhibitory activity. Depicted moiety for strong inhibition activity matches to the structure of most potent compound. MD simulation has revealed importance of imidazolinyl and phenyl groups in the mechanism of binding into the active site of human DPP III.

A study of solar preflare activity using two-dimensional radio and SMM-XRP observations

NASA Technical Reports Server (NTRS)

Kundu, M. R.; Gopalswamy, N.; Saba, J. L. R.; Schmelz, J. T. S.; Strong, K. T.

1987-01-01

A study of type III activity at meter-decameter wavelengths in the preflare phase of the February 3, 1986 flare is presented, using data obtained with the Clark Lake Multifrequency Radioheliograph. This activity is compared with similar type III burst activity during the impulsive phase, and it is found that there is a displacement of burst sources between the onset and end times of the activity. A comparison of this displacement at three frequencies suggests that the type III emitting electrons gain access progressively to diverging and different field lines relative to the initial field lines. The energetics of the type III emitting electrons are inferred from observations and compared with those of the associated hard X-ray emitting electrons. The soft X-ray data from SMM-XRP show enhanced emission measure, density, and temperature in the region associated with the preflare type III activity.

A study of solar preflare activity using two-dimensional radio and SMM-XRP observations

NASA Astrophysics Data System (ADS)

Kundu, M. R.; Gopalswamy, N.; Saba, J. L. R.; Schmelz, J. T. S.; Strong, K. T.

1987-09-01

The authors present a study of type III activity at meter-decameter wavelengths in the preflare phase of the 1986 February 3 flare using data obtained with the Clark Lake Multifrequency Radioheliograph. They compare this activity with similar type III burst activity during the impulsive phase and find that there is a displacement of burst sources between the onset and end times of the activity. A comparison of this displacement at three frequencies suggests that the type III emitting electrons gain access progressively to diverging and different field lines relative to the initial field lines. The energetics of the type III emitting electrons are inferred from observations and compared with those of the associated hard X-ray emitting electrons. The soft X-ray data from SMM-XRP shows enhanced emission measure, density and temperature in the region associated with the preflare type III activity.

Characterization of ribonuclease III from Brucella.

PubMed

Wu, Chang-Xian; Xu, Xian-Jin; Zheng, Ke; Liu, Fang; Yang, Xu-Dong; Chen, Chuang-Fu; Chen, Huan-Chun; Liu, Zheng-Fei

2016-04-01

Bacterial ribonuclease III (RNase III) is a highly conserved endonuclease, which plays pivotal roles in RNA maturation and decay pathways by cleaving double-stranded structure of RNAs. Here we cloned rncS gene from the genomic DNA of Brucella melitensis, and analyzed the cleavage properties of RNase III from Brucella. We identified Brucella-encoding small RNA (sRNA) by high-throughput sequencing and northern blot, and found that sRNA of Brucella and Homo miRNA precursor (pre-miRNA) can be bound and cleaved by B.melitensis ribonuclease III (Bm-RNase III). Cleavage activity of Bm-RNase III is bivalent metal cations- and alkaline buffer-dependent. We constructed several point mutations in Bm-RNase III, whose cleavage activity indicated that the 133th Glutamic acid residue was required for catalytic activity. Western blot revealed that Bm-RNase III was differently expressed in Brucella virulence strain 027 and vaccine strain M5-90. Collectively, our data suggest that Brucella RNase III can efficiently bind and cleave stem-loop structure of small RNA, and might participate in regulation of virulence in Brucella. Copyright © 2016 Elsevier B.V. All rights reserved.

Pyrroloindolone synthesis via a Cp*Co(III)-catalyzed redox-neutral directed C-H alkenylation/annulation sequence.

PubMed

Ikemoto, Hideya; Yoshino, Tatsuhiko; Sakata, Ken; Matsunaga, Shigeki; Kanai, Motomu

2014-04-09

A unique synthetic utility of a Cp*Co(III) catalyst in comparison with related Cp*Rh(III) catalysts is described. A C2-selective indole alkenylation/annulation sequence proceeded smoothly with catalytic amount of a [Cp*Co(III)(C6H6)](PF6)2 complex and KOAc. Intramolecular addition of an alkenyl-Cp*Co species to a carbamoyl moiety gave pyrroloindolones in 58-89% yield in one pot. Clear difference was observed between the catalytic activity of the Cp*Co(III) complex and those of Cp*Rh(III) complexes, highlighting the unique nucleophilic activity of the organocobalt species. The Cp*Co(III) catalysis was also suitable for simple alkenylation process of N-carbamoyl indoles, and broad range of alkynes, including terminal alkynes, were applicable to give C2-alkenylated indoles in 50-99% yield. Mechanistic studies on C-H activation step under Cp*Co(III) catalysis with the aid of an acetate unit as well as evaluation of the difference between organo-Co(III) species and organo-Rh(III) species are also described.

Identifying inaccuracy of MS Project using system analysis

NASA Astrophysics Data System (ADS)

Fachrurrazi; Husin, Saiful; Malahayati, Nurul; Irzaidi

2018-05-01

The problem encountered in project owner’s financial accounting report is the difference in total project costs of MS Project to the Indonesian Standard (Standard Indonesia Standard / Cost Estimating Standard Book of Indonesia). It is one of the MS Project problems concerning to its cost accuracy, so cost data cannot be used in an integrated way for all project components. This study focuses on finding the causes of inaccuracy of the MS Projects. The aim of this study, which is operationally, are: (i) identifying cost analysis procedures for both current methods (SNI) and MS Project; (ii) identifying cost bias in each element of the cost analysis procedure; and (iii) analysing the cost differences (cost bias) in each element to identify what the cause of inaccuracies in MS Project toward SNI is. The method in this study is comparing for both the system analysis of MS Project and SNI. The results are: (i) MS Project system in Work of Resources element has limitation for two decimal digits only, have led to its inaccuracy. Where the Work of Resources (referred to as effort) in MS Project represents multiplication between the Quantities of Activities and Requirements of resources in SNI; (ii) MS Project and SNI have differences in the costing methods (the cost estimation methods), in which the SNI uses the Quantity-Based Costing (QBC), meanwhile MS Project uses the Time-Based Costing (TBC). Based on this research, we recommend to the contractors who use SNI should make an adjustment for Work of Resources in MS Project (with correction index) so that it can be used in an integrated way to the project owner’s financial accounting system. Further research will conduct for improvement the MS Project as an integrated tool toward all part of the project participant.

John Simon | NREL

Science.gov Websites

novel crystalline substrates for growth of III-V Nitride semiconductors for solid-state lighting applications. Since then he has been involved in various projects involving the growth of III-V semiconductor .; Romero, M.; and Lee, M.J. "Metamorphic GaAsP buffers for growth of wide-bandgap InGaP solar cells

Feasibility planning study for a behavior database. Volume III Appendix B, Compendium of survey questions on drinking and driving and occupant restraints

DOT National Transportation Integrated Search

1987-04-01

The general objective of the project was to determine the feasibility of and the general requirements for a centralized database on driver behavior and attitudes related to drunk driving and occupant restraints. Volume III is a compendium of question...

New York State Title III NDEA Planning Guide. Revised Edition, 1967-68.

ERIC Educational Resources Information Center

New York State Education Dept., Albany.

This document provides guidelines for public school authorities who wish to avail themselves of the opportunities provided by the Title III NDEA programs. The document outlines participation in the program in terms of--(1) application procedures, (2) reimbursement procedures, (3) special projects, (4) priority considerations, (5) basic standards…

Small Systems Use of a Solid Arsenic Oxidizing Media in Place of Chemical Oxidation to Enhance Arsenic Removal

EPA Science Inventory

Presentation provides information on the need to oxidize As III to As V to increase arsenic removal followed by information on the results of an arsenic demonstration project (Plainview CDS) using a solid oxidizing media (Filox) to oxidize As III. The presentation includes a sho...

76 FR 80356 - Combined Notice of Filings #1

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-23

... of the Federal Power Act. Filed Date: 12/14/2011. Accession Number: 20111214-5145. Comments Due: 5 p.m. ET 1/4/12. Docket Numbers: EC12-49-000. Applicants: Shiloh III Wind Project, LLC, Shiloh III Lessee, LLC. Description: Joint Application for Authorization under Section 203 of the Federal Power Act...

Directory of Mediated Instructional Materials.

ERIC Educational Resources Information Center

Mitchell, Louise, Ed.

Catalogued in this directory are all the audio tapes, video tapes, and films produced from 1964 through 1969 by the Evanston Township High School Faculty, its Title III staff, and its television staff in the course of its Title III project. These instructional materials are designed for secondary school students and cover almost all aspects of the…

Technical Reports (Part I). End of Project Report, 1968-1971, Volume III.

ERIC Educational Resources Information Center

Western Nevada Regional Education Center, Lovelock.

The pamphlets included in this volume are technical reports prepared as outgrowths of the Student Information Systems of the Western Nevada Regional Education Center (WN-REC) funded by a Title III (Elementary and Secondary Education Act) grant. These reports describe methods of interpreting the printouts from the Student Information System;…

Human Rehabilitation Techniques. Contract Papers. Volume III, Part B.

ERIC Educational Resources Information Center

Ross, E. C.; And Others

Volume III, Section B of a six-volume final report (which covers the findings of a research project on policy and technology related to rehabilitation of disabled individuals) presents four papers which examine important rehabilitation-oriented issues. In the first paper, "Transportation Problems of Persons with Disabilities--The Federal Response"…

SAGE III/ISS L2 Solar Event Species Profiles (Native) V5 (g3bsspb)

Atmospheric Science Data Center

2017-12-21

SAGE III/ISS L2 Solar Event Species Profiles (Native) V5 (g3bsspb)   Project ... present Temporal Resolution:  1 file per event File Format:  BINARY Tools:  Earthdata ... Radiation Longwave Radiation Shortwave Radiation Event Tag Event Type Obs Beta Angle Order Data:  ...

SAGE III/ISS L2 Lunar Event Species Profiles (Native) V5 (g3blspb)

Atmospheric Science Data Center

2018-01-08

SAGE III/ISS L2 Lunar Event Species Profiles (Native) V5 (g3blspb)   Project ... present Temporal Resolution:  1 file per event File Format:  BINARY Tools:  Earthdata ... Radiation Longwave Radiation Shortwave Radiation Event Tag Event Type Obs Beta Angle Order Data:  ...

Kenston Aerospace: Title III ESEA Project.

ERIC Educational Resources Information Center

Kenston Local School District, Chagrin Falls, OH.

The objectives of a three-year comprehensive aerospace education program at Kenston High School, Chagrin Falls, Ohio, funded under Title III ESEA, were to provide marketable skills for non-College-bound students as well as counseling for the student planning on college or technical school education in the aviation field. Students also were taught…

Highway concrete pavement technology development and testing. Volume 5, Field evaluation of Strategic Highway Research Program (SHRP) C-206 test sites (bridge deck overlays)

DOT National Transportation Integrated Search

2006-08-01

Two types of concrete overlays silica fume concrete (SFC) and latex-modified Type III portland cement concrete (LMC-III) were installed ant tested as part of the Strategic Highway Research Program (SHRP) Project C-206: Optimization of Highway Concret...

77 FR 5007 - Combined Notice of Filings #2

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-01

...; ER11-2488-002; ER10-3032-002; ER11-2475-002. Applicants: Klondike Wind Power III LLC, Northern Iowa... Windpower LLC, Flying Cloud Power Partners, LLC, Klamath Energy LLC, Klamath Generation LLC, Moraine Wind LLC, Mountain View Power Partners III, LLC, Shiloh I Wind Project, LLC, Trimont Wind I LLC, Locust...

34 CFR 359.31 - What selection criteria does the Secretary use in reviewing applications under this program?

Code of Federal Regulations, 2010 CFR

2010-07-01

... ethnic minority groups; (ii) Women; (iii) Individuals with disabilities; and (iv) The elderly. (d... racial or ethnic minority groups; (ii) Women; (iii) Individuals with disabilities; and (iv) The elderly... costs are reasonable in relation to the objectives of the project; and (3) The budget for subcontracts...

The Mississippi Catalog of Competencies for Public Elementary and Secondary Physical Education.

ERIC Educational Resources Information Center

Mississippi State Dept. of Education, Jackson.

Phase III of a five-phase project which has implications for the improvement of instructional programs in Mississippi's elementary and secondary schools is described. In phase III, specifically stated objectives or competencies in physical education, designed to accomplish the objectives stated in phase II, are cataloged. The competencies are…

Potential for a hazardous geospheric response to projected future climate changes.

PubMed

McGuire, B

2010-05-28

Periods of exceptional climate change in Earth history are associated with a dynamic response from the geosphere, involving enhanced levels of potentially hazardous geological and geomorphological activity. The response is expressed through the adjustment, modulation or triggering of a broad range of surface and crustal phenomena, including volcanic and seismic activity, submarine and subaerial landslides, tsunamis and landslide 'splash' waves, glacial outburst and rock-dam failure floods, debris flows and gas-hydrate destabilization. In relation to anthropogenic climate change, modelling studies and projection of current trends point towards increased risk in relation to a spectrum of geological and geomorphological hazards in a warmer world, while observations suggest that the ongoing rise in global average temperatures may already be eliciting a hazardous response from the geosphere. Here, the potential influences of anthropogenic warming are reviewed in relation to an array of geological and geomorphological hazards across a range of environmental settings. A programme of focused research is advocated in order to: (i) understand better those mechanisms by which contemporary climate change may drive hazardous geological and geomorphological activity; (ii) delineate those parts of the world that are most susceptible; and (iii) provide a more robust appreciation of potential impacts for society and infrastructure.

Enhanced anti-cancer activities of a gold(III) pyrrolidinedithiocarbamato complex incorporated in a biodegradable metal-organic framework.

PubMed

Sun, Raymond Wai-Yin; Zhang, Ming; Li, Dan; Li, Mian; Wong, Alice Sze-Tsai

2016-10-01

An anti-cancer active gold(III) pyrrolidinedithiocarbamato complex [(PDTC)Au III Cl 2 ] (1) has been synthesized and characterized by means of X-ray crystallography. Compared to the pyrrolidinedithiocarbamate ligand itself, this gold(III) complex displays an up to 33-fold higher anti-cancer potency towards a panel of cancer cell lines including the cisplatin-resistant ovarian carcinoma cell line (A2780cis). As demonstrated by a set of Transwell® assay-based cytotoxicity experiments, incorporating this gold(III) complex in a zinc-based biodegradable metal-organic framework (MOF) displays a significant enhancement in anti-cancer activity towards A2780cis than the gold(III) complex alone. Copyright © 2016 Elsevier Inc. All rights reserved.

Applied Meteorology Unit (AMU)

NASA Technical Reports Server (NTRS)

Bauman, William; Crawford, Winifred; Barrett, Joe; Watson, Leela; Wheeler, Mark

2010-01-01

This report summarizes the Applied Meteorology Unit (AMU) activities for the first quarter of Fiscal Year 2010 (October - December 2009). A detailed project schedule is included in the Appendix. Included tasks are: (1) Peak Wind Tool for User Launch Commit Criteria (LCC), (2) Objective Lightning Probability Tool, Phase III, (3) Peak Wind Tool for General Forecasting, Phase II, (4) Upgrade Summer Severe Weather Tool in Meteorological Interactive Data Display System (MIDDS), (5) Advanced Regional Prediction System (ARPS) Data Analysis System (ADAS) Update and Maintainability, (5) Verify 12-km resolution North American Model (MesoNAM) Performance, and (5) Hybrid Single-Particle Lagrangian Integrated Trajectory (HYSPLIT) Graphical User Interface.

NASA Dryden Status

NASA Technical Reports Server (NTRS)

Jacobson, Steve R.

2009-01-01

This slide presentation reviews several projects that NASA Dryden personnel are involved with: Integrated Resilient Aircraft Controls Project (IRAC), NASA G-III Research Aircraft, X-48B Blended Wing Body aircraft, Stratospheric Observatory for Infrared Astronomy (SOFIA), and the Orion CEV Launch Abort Systems Tests.

The spatiotopic 'visual' cortex of the blind

NASA Astrophysics Data System (ADS)

Likova, Lora

2012-03-01

Visual cortex activity in the blind has been shown in sensory tasks. Can it be activated in memory tasks? If so, are inherent features of its organization meaningfully employed? Our recent results in short-term blindfolded subjects imply that human primary visual cortex (V1) may operate as a modality-independent 'sketchpad' for working memory (Likova, 2010a). Interestingly, the spread of the V1 activation approximately corresponded to the spatial extent of the images in terms of their angle of projection to the subject. We now raise the questions of whether under long-term visual deprivation V1 is also employed in non-visual memory task, in particular in congenitally blind individuals, who have never had visual stimulation to guide the development of the visual area organization, and whether such spatial organization is still valid for the same paradigm that was used in blindfolded individuals. The outcome has implications for an emerging reconceptualization of the principles of brain architecture and its reorganization under sensory deprivation. Methods: We used a novel fMRI drawing paradigm in congenitally and late-onset blind, compared with sighted and blindfolded subjects in three conditions of 20s duration, separated by 20s rest-intervals, (i) Tactile Exploration: raised-line images explored and memorized; (ii) Tactile Memory Drawing: drawing the explored image from memory; (iii) Scribble: mindless drawing movements with no memory component. Results and Conclusions: V1 was strongly activated for Tactile Memory Drawing and Tactile Exploration in these totally blind subjects. Remarkably, after training, even in the memory task, the mapping of V1 activation largely corresponded to the angular projection of the tactile stimuli relative to the ego-center (i.e., the effective visual angle at the head); beyond this projective boundary, peripheral V1 signals were dramatically reduced or even suppressed. The matching extent of the activation in the congenitally blind rules out vision-based explanatory mechanisms, and supports the more radical idea of V1 as a modality-independent 'projection screen' or a 'sketchpad', whose mapping scales to the projective dimensions of objects explored in the peri-personal space.

Problems Perceived by Educational Leadership: PROJECT DESIGN, Interagency Planning for Urban Educational Needs, Number 6.

ERIC Educational Resources Information Center

Fresno City Unified School District, CA.

This report is one in a series of needs assessment publications that comprise the initial phase for PROJECT DESIGN, an ESEA Title III project administered by the Fresno City Unified School District. This report summarizes educational problems of Fresno as they were perceived by district educational leaders. One researcher interviewed five members…

Lafayette Parish Cooperative Jail Project--LPCJP. Phase III Final Report.

ERIC Educational Resources Information Center

Lafayette Parish School Board, LA.

A three-phase project was conducted to further the education of inmates in the Lafayette (Louisiana) Parish Correctional Center. Phase I of the project was designed to prepare inmates to be eligible to take the General Educational Development (GED) test, and/or to teach life-coping skills so that they would better function in society upon their…

Topical Modules in Secondary Mathematics. Final Project Report.

ERIC Educational Resources Information Center

Fresno City Unified School District, CA.

Summative evaluation of an ESEA Title III project designed to raise the mathematics achievement scores of low achievers in grades 10 and 11 is reported. In a summer writing project, teachers developed 21 arithmetic modules and 11 algebra modules for use by students on an individual basis. Students used the modules at their own pace and stayed with…

Adult Dyslexia and Attention Deficit Disorder in Finland--Project DyAdd: WAIS-III Cognitive Profiles

ERIC Educational Resources Information Center

Laasonen, Marja; Leppamaki, Sami; Tani, Pekka; Hokkanen, Laura

2009-01-01

The project Adult Dyslexia and Attention Deficit Disorder in Finland (Project DyAdd) compares adults (n = 119, 18-55 years) with dyslexia, attention-deficit/hyperactivity disorder (ADHD), dyslexia together with ADHD (comorbid), and healthy controls with neuropsychological, psychophysical, and biological methods. The focus of this article is on the…

1L Mark-IV Target Design Review

DOE Office of Scientific and Technical Information (OSTI.GOV)

Koehler, Paul E.

This presentation includes General Design Considerations; Current (Mark-III) Lower Tier; Mark-III Upper Tier; Performance Metrics; General Improvements for Material Science; General Improvements for Nuclear Science; Improving FOM for Nuclear Science; General Design Considerations Summary; Design Optimization Studies; Expected Mark-IV Performance: Material Science; Expected Mark-IV Performance: Nuclear Science (Disk); Mark IV Enables Much Wider Range of Nuclear-Science FOM Gains than Mark III; Mark-IV Performance Summary; Rod or Disk? Center or Real FOV?; and Project Cost and Schedule.

Oxoiron(IV) complexes as synthons for the assembly of heterobimetallic centers such as the Fe/Mn active site of Class Ic ribonucleotide reductases.

PubMed

Zhou, Ang; Crossland, Patrick M; Draksharapu, Apparao; Jasniewski, Andrew J; Kleespies, Scott T; Que, Lawrence

2018-01-01

Nonheme oxoiron(IV) complexes can serve as synthons for generating heterobimetallic oxo-bridged dimetal complexes by reaction with divalent metal complexes. The formation of Fe III -O-Cr III and Fe III -O-Mn III complexes is described herein. The latter complexes may serve as models for the Fe III -X-Mn III active sites of an emerging class of Fe/Mn enzymes represented by the Class 1c ribonucleotide reductase from Chlamydia trachomatis and the R2-like ligand-binding oxidase (R2lox) found in Mycobacterium tuberculosis. These synthetic complexes have been characterized by UV-Vis, resonance Raman, and X-ray absorption spectroscopy, as well as electrospray mass spectrometry. The Fe III -O-Cr III complexes exhibit a three-band UV-Vis pattern that differs from the simpler features associated with Fe III -O-Fe III complexes. The positions of these features are modulated by the nature of the supporting polydentate ligand on the iron center, and their bands intensify dramatically in two examples upon the binding of an axial cyanate or thiocyanate ligand trans to the oxo bridge. In contrast, the Fe III -O-Mn III complexes resemble Fe III -O-Fe III complexes more closely. Resonance Raman characterization of the Fe III -O-M III complexes reveals an 18 O-sensitive vibration in the range of 760-890 cm -1 . This feature has been assigned to the asymmetric Fe III -O-M III stretching mode and correlates reasonably with the Fe-O bond distance determined by EXAFS analysis. The likely binding of an acetate as a bridging ligand to the Fe III -O-Mn III complex 12 lays the foundation for further efforts to model the heterobimetallic active sites of Fe/Mn enzymes.

c-Maf is required for the development of dorsal horn laminae III/IV neurons and mechanoreceptive DRG axon projections.

PubMed

Hu, Jia; Huang, Tianwen; Li, Tingting; Guo, Zhen; Cheng, Leping

2012-04-18

Establishment of proper connectivity between peripheral sensory neurons and their central targets is required for an animal to sense and respond to various external stimuli. Dorsal root ganglion (DRG) neurons convey sensory signals of different modalities via their axon projections to distinct laminae in the dorsal horn of the spinal cord. In this study, we found that c-Maf was expressed predominantly in the interneurons of laminae III/IV, which primarily receive inputs from mechanoreceptive DRG neurons. In the DRG, c-Maf⁺ neurons also coexpressed neurofilament-200, a marker for the medium- and large-diameter myelinated afferents that transmit non-noxious information. Furthermore, mouse embryos deficient in c-Maf displayed abnormal development of dorsal horn laminae III/IV neurons, as revealed by the marked reduction in the expression of several marker genes for these neurons, including those for transcription factors MafA and Rora, GABA(A) receptor subunit α5, and neuropeptide cholecystokinin. In addition, among the four major subpopulations of DRG neurons marked by expression of TrkA, TrkB, TrkC, and MafA/GFRα2/Ret, c-Maf was required selectively for the proper differentiation of MafA⁺/Ret⁺/GFRα2⁺ low-threshold mechanoreceptors (LTMs). Last, we found that the central and peripheral projections of mechanoreceptive DRG neurons were compromised in c-Maf deletion mice. Together, our results indicate that c-Maf is required for the proper development of MafA⁺/Ret⁺/GFRα2⁺ LTMs in the DRG, their afferent projections in the dorsal horn and Pacinian corpuscles, as well as neurons in laminae III/IV of the spinal cord.

Beta-ketoacyl-acyl carrier protein synthase III from pea (Pisum sativum L.): properties, inhibition by a novel thiolactomycin analogue and isolation of a cDNA clone encoding the enzyme.

PubMed

Jones, A Lesley; Gane, Andy M; Herbert, Derek; Willey, David L; Rutter, Andrew J; Kille, Peter; Dancer, Jane E; Harwood, John L

2003-03-01

A beta-ketoacyl-acyl carrier protein (ACP) synthase III (KAS III; short-chain condensing enzyme) has been partly purified from pea leaves. The enzyme, which had acetyl-CoA:ACP acyltransferase (ACAT) activity, was resolved from a second, specific, ACAT protein. The KAS III enzyme had a derived molecular mass of 42 kDa (from its cDNA sequence) and operated as a dimer. Its enzymological characteristics were similar to those of two other plant KAS III enzymes except for its inhibition by thiolactomycin. A derivative of thiolactomycin containing a longer (C8 saturated) hydrophobic side-chain (compound 332) was a more effective inhibitor of pea KAS III and showed competitive inhibition towards malonyl-ACP whereas thiolactomycin showed uncompetitive characteristics at high concentrations. This difference may be due to the better fit of compound 332 into a hydrophobic pocket at the active site. A full-length cDNA for the pea KAS III was isolated. This was expressed in Escherichia coli as a fusion protein with glutathione S-transferase in order to facilitate subsequent purification. Demonstrated activity in preparations from E. coli confirmed that the cDNA encoded a KAS III enzyme. Furthermore, the expressed KAS III had ACAT activity, showing that the latter was inherent. The derived amino acid sequence of the pea cDNA showed 81-87% similarity to that for other plant dicotyledon KAS IIIs, somewhat less for Allium porrum (leek, 71%) and for Porphyra spp. (62%), Synechocystis spp. (65%) and various bacteria (42-65%). The pea KAS III exhibited four areas of homology, three of which were around the active-site Cys(123), His(323) and Asn(353). In addition, a stretch of 23 amino acids (residues 207-229 in the pea KAS III) was almost completely conserved in the plant KAS IIIs. Modelling this stretch showed they belonged to a peptide fragment that fitted over the active site and contained segments suggested to be involved in substrate binding and in conformational changes during catalysis, as well as an arginine suggested to participate in the acid-base catalytic mechanism.

Cooperative Program Improvement; An Experiment in ABE In-Service Training. Doolittle Family Education Center Experimental In-Service Training Project. Final Report.

ERIC Educational Resources Information Center

Griffith, William S.; And Others

This document, consisting of seven chapters and 12 appendixes, is a full final report of the Doolittle Family Education Center Experimental In-Service Training Project. Chapter II consists of the history and plan of the project including an explanation of the framework of the model that was used to conceptualize the project. Chapter III is a…

Effects of Al(III) and Nano-Al13 Species on Malate Dehydrogenase Activity

PubMed Central

Yang, Xiaodi; Cai, Ling; Peng, Yu; Li, Huihui; Chen, Rong Fu; Shen, Ren Fang

2011-01-01

The effects of different aluminum species on malate dehydrogenase (MDH) activity were investigated by monitoring amperometric i-t curves for the oxidation of NADH at low overpotential using a functionalized multi-wall nanotube (MWNT) modified glass carbon electrode (GCE). The results showed that Al(III) and Al13 can activate the enzymatic activity of MDH, and the activation reaches maximum levels as the Al(III) and Al13 concentration increase. Our study also found that the effects of Al(III) and Al13 on the activity of MDH depended on the pH value and aluminum speciation. Electrochemical and circular dichroism spectra methods were applied to study the effects of nano-sized aluminum compounds on biomolecules. PMID:22163924

Effects of Al(III) and nano-Al13 species on malate dehydrogenase activity.

PubMed

Yang, Xiaodi; Cai, Ling; Peng, Yu; Li, Huihui; Chen, Rong Fu; Shen, Ren Fang

2011-01-01

The effects of different aluminum species on malate dehydrogenase (MDH) activity were investigated by monitoring amperometric i-t curves for the oxidation of NADH at low overpotential using a functionalized multi-wall nanotube (MWNT) modified glass carbon electrode (GCE). The results showed that Al(III) and Al(13) can activate the enzymatic activity of MDH, and the activation reaches maximum levels as the Al(III) and Al(13) concentration increase. Our study also found that the effects of Al(III) and Al(13) on the activity of MDH depended on the pH value and aluminum speciation. Electrochemical and circular dichroism spectra methods were applied to study the effects of nano-sized aluminum compounds on biomolecules.

Neural control of salivary glands in ixodid ticks.

PubMed

Šimo, Ladislav; Zitňan, Dušan; Park, Yoonseong

2012-04-01

Studies of tick salivary glands (SGs) and their components have produced a number of interesting discoveries over the last four decades. However, the precise neural and physiological mechanisms controlling SG secretion remain enigmatic. Major studies of SG control have identified and characterized many pharmacological and biological compounds that activate salivary secretion, including dopamine (DA), octopamine, γ-aminobutyric acid (GABA), ergot alkaloids, pilocarpine (PC), and their pharmacological relatives. Specifically, DA has shown the most robust activities in various tick species, and its effect on downstream actions in the SGs has been extensively studied. Our recent work on a SG dopamine receptor has aided new interpretations of previous pharmacological studies and provided new concepts for SG control mechanisms. Furthermore, our recent studies have suggested that multiple neuropeptides are involved in SG control. Myoinhibitory peptide (MIP) and SIFamide have been identified in the neural projections reaching the basal cells of acini types II and III. Pigment-dispersing factor (PDF)-immunoreactive neural projections reach type II acini, and RFamide- and tachykinin-immunoreactive projections reach the SG ducts, but the chemical nature of the latter three immunoreactive substances are unidentified yet. Here, we briefly review previous pharmacological studies and provide a revised summary of SG control mechanisms in ticks. Copyright © 2011 Elsevier Ltd. All rights reserved.

Synthesis, antiproliferative activity and mechanism of gallium(III)-thiosemicarbazone complexes as potential anti-breast cancer agents.

PubMed

Qi, Jinxu; Yao, Qian; Qian, Kun; Tian, Liang; Cheng, Zhen; Yang, Dongmei; Wang, Yihong

2018-05-14

Five thiosemicarbazone ligands were synthesized and characterized by condensation with different aldehydes or ketones by 4-phenylthiosemicarbazone. The representative dichlorido[2-(Di-2-pyridinylmethylene)-Nphenylhydrazinecarbothioamide-N,N,S]-gallium(III) (Ga4) was characterized by X-ray single crystal diffraction, which was 1:1 ligand/Ga(III) complexes. The structure-activity relationship of these ligands and Ga (III) complexes have been investigated, and the results demonstrate that the formation of Ga (III) complexes have significant antiproliferative activity over the corresponding ligands. The anticancer mechanism of gallium (III) complexes has been studied in detail, which is typical agents that effect on the mitochondrial apoptotic pathway. The ability of gallium (III) complexes to inhibit the cell cycle does not enhanced with the increasing concentrations, whereas the ability to promote apoptosis is concentration-dependent. Copyright © 2018 Elsevier Masson SAS. All rights reserved.

Maintenance Decision Support System, Phase III

DOT National Transportation Integrated Search

2017-09-01

The main goal of the project was to address barriers that limit NDOTs ability to implement MDSS and MMS systems. The four project tasks included: Task 1: Develop system for tracking sand and/or deicing material usage: A system that tracks where and w...

An Example of Process Evaluation.

ERIC Educational Resources Information Center

Karl, Marion C.

The inappropriateness of standard experimental research design, which can stifle innovations, is discussed in connection with the problems of designing practical techniques for evaluating a Title III curriculum development project. The project, involving 12 school districts and 2,500 students, teaches concept understanding, critical thinking, and…

75 FR 39779 - National Institute on Disability and Rehabilitation Research (NIDRR)-Disability and...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-12

... Part III Department of Education National Institute on Disability and Rehabilitation Research (NIDRR)-- Disability and Rehabilitation Research Projects and Centers Program-- Disability Rehabilitation Research Project (DRRP)--Center on Knowledge Translation (KT) for Employment Research (Center); Notices #0...

Mitochondria are the main target organelle for trivalent monomethylarsonous acid (MMA(III))-induced cytotoxicity.

PubMed

Naranmandura, Hua; Xu, Shi; Sawata, Takashi; Hao, Wen Hui; Liu, Huan; Bu, Na; Ogra, Yasumitsu; Lou, Yi Jia; Suzuki, Noriyuki

2011-07-18

Excessive generation of reactive oxygen species (ROS) is considered to play an important role in arsenic-induced carcinogenicity in the liver, lungs, and urinary bladder. However, little is known about the mechanism of ROS-based carcinogenicity, including where the ROS are generated, and which arsenic species are the most effective ROS inducers. In order to better understand the mechanism of arsenic toxicity, rat liver RLC-16 cells were exposed to arsenite (iAs(III)) and its intermediate metabolites [i.e., monomethylarsonous acid (MMA(III)) and dimethylarsinous acid (DMA(III))]. MMA(III) (IC(50) = 1 μM) was found to be the most toxic form, followed by DMA(III) (IC(50) = 2 μM) and iAs(III) (IC(50) = 18 μM). Following exposure to MMA(III), ROS were found to be generated primarily in the mitochondria. DMA(III) exposure resulted in ROS generation in other organelles, while no ROS generation was seen following exposures to low levels of iAs(III). This suggests the mechanisms of induction of ROS are different among the three arsenicals. The effects of iAs(III), MMA(III), and DMA(III) on activities of complexes I-IV in the electron transport chain (ETC) of rat liver submitochondrial particles and on the stimulation of ROS production in intact mitochondria were also studied. Activities of complexes II and IV were significantly inhibited by MMA(III), but only the activity of complexes II was inhibited by DMA(III). Incubation with iAs(III) had no inhibitory effects on any of the four complexes. Generation of ROS in intact mitochondria was significantly increased following incubation with MMA(III), while low levels of ROS generation were observed following incubation with DMA(III). ROS was not produced in mitochondria following exposure to iAs(III). The mechanism underlying cell death is different among As(III), MMA(III), and DMA(III), with mitochondria being one of the primary target organelles for MMA(III)-induced cytotoxicity. © 2011 American Chemical Society

Characterization and Properties of Activated Carbon Prepared from Tamarind Seeds by KOH Activation for Fe(III) Adsorption from Aqueous Solution

PubMed Central

Mopoung, Sumrit; Moonsri, Phansiri; Palas, Wanwimon; Khumpai, Sataporn

2015-01-01

This research studies the characterization of activated carbon from tamarind seed with KOH activation. The effects of 0.5 : 1–1.5 : 1 KOH : tamarind seed charcoal ratios and 500–700°C activation temperatures were studied. FTIR, SEM-EDS, XRD, and BET were used to characterize tamarind seed and the activated carbon prepared from them. Proximate analysis, percent yield, iodine number, methylene blue number, and preliminary test of Fe(III) adsorption were also studied. Fe(III) adsorption was carried out by 30 mL column with 5–20 ppm Fe(III) initial concentrations. The percent yield of activated carbon prepared from tamarind seed with KOH activation decreased with increasing activation temperature and impregnation ratios, which were in the range from 54.09 to 82.03 wt%. The surface functional groups of activated carbon are O–H, C=O, C–O, –CO3, C–H, and Si–H. The XRD result showed high crystallinity coming from a potassium compound in the activated carbon. The main elements found in the activated carbon by EDS are C, O, Si, and K. The results of iodine and methylene blue adsorption indicate that the pore size of the activated carbon is mostly in the range of mesopore and macropore. The average BET pore size and BET surface area of activated carbon are 67.9764 Å and 2.7167 m2/g, respectively. Finally, the tamarind seed based activated carbon produced with 500°C activation temperature and 1.0 : 1 KOH : tamarind seed charcoal ratio was used for Fe(III) adsorption test. It was shown that Fe(III) was adsorbed in alkaline conditions and adsorption increased with increasing Fe(III) initial concentration from 5 to 20 ppm with capacity adsorption of 0.0069–0.019 mg/g. PMID:26689357

Light-activated protein inhibition through photoinduced electron transfer of a ruthenium(II)–cobalt(III) bimetallic complex

DOE PAGES

Holbrook, Robert J.; Weinberg, David J.; Peterson, Mark D.; ...

2015-02-11

In this paper, we describe a mechanism of light activation that initiates protein inhibitory action of a biologically inert Co(III) Schiff base (Co(III)-sb) complex. Photoinduced electron transfer (PET) occurs from a Ru(II) bipyridal complex to a covalently attached Co(III) complex and is gated by conformational changes that occur in tens of nanoseconds. Reduction of the Co(III)-sb by PET initiates displacement of the inert axial imidazole ligands, promoting coordination to active site histidines of α-thrombin. Upon exposure to 455 nm light, the rate of ligand exchange with 4-methylimidazole, a histidine mimic, increases by approximately 5-fold, as observed by NMR spectroscopy. Similarly,more » the rate of α-thrombin inhibition increases over 5-fold upon irradiation. Finally, these results convey a strategy for light activation of inorganic therapeutic agents through PET utilizing redox-active metal centers.« less

End-user involvement in a systematic review of quantitative and qualitative research of non-pharmacological interventions for attention deficit hyperactivity disorder delivered in school settings: reflections on the impacts and challenges.

PubMed

Coon, Jo Thompson; Gwernan-Jones, Ruth; Moore, Darren; Richardson, Michelle; Shotton, Catherine; Pritchard, Will; Morris, Christopher; Stein, Ken; Ford, Tamsin

2016-10-01

The benefits of end-user involvement in health-care research are widely recognized by research agencies. There are few published evaluations of end-user involvement in systematic reviews. (i) Describe end-user involvement in a complex mixed-methods systematic review of ADHD in schools, (ii) reflect on the impact of end-user involvement, (iii) highlight challenges and benefits experienced and (iv) provide suggestions to inform future involvement. End-users were involved in all stages of the project, both as authors and as members of an advisory group. In addition, several events were held with groups of relevant end-users during the project. End-user input (i) guided the direction of the research, (ii) contributed to a typology of interventions and outcomes, (iii) contributed to the direction of data analysis and (iv) contributed to the robustness of the syntheses by demonstrating the alignment of interim findings with lived experiences. Challenges included (i) managing expectations, (ii) managing the intensity of emotion, (iii) ensuring that involvement was fruitful for all not just the researcher, (iv) our capacity to communicate and manage the process and (v) engendering a sense of involvement amongst end-users. End-user involvement was an important aspect of this project. To minimize challenges in future projects, a recognition by the project management team and the funding provider that end-user involvement even in evidence synthesis projects is resource intensive is essential to allow appropriate allocation of time and resources for meaningful engagement. © 2015 The Authors. Health Expectations. Published by John Wiley & Sons Ltd.

CASBaH: the Multiphase Circumgalactic Medium During the Decline of Cosmic Star Formation

NASA Astrophysics Data System (ADS)

Burchett, Joseph N.; Tripp, Todd; Prochaska, Jason; Werk, Jessica; Willmer, Christopher; Ford, Amanda Brady; Howk, Chris

2018-01-01

The COS Absorption Survey of Baryon Harbors (CASBaH) comprises high-S/N spectra of nine z > 0.9 QSOs with coverage from the far-ultraviolet to the optical. These sightlines access the rich suite of rest-frame extreme-ultraviolet (600 - 1000 Angstroms) spectral transitions, such as Ne VIII, Mg X, and O II/III/IV, in addition to those more well studied at longer wavelengths (O VI, C III, Mg II). We have undertaken a large ground-based spectroscopic follow-up campaign to identify galaxies projected near the QSO sightlines and leverage the myriad diagnostics within the QSO spectra to study the circumgalactic medium (CGM) at 0.2 < z < 1 over the crucial epoch when star formation activity in the Universe was in sharp decline. We will present results from this multiwavelength study characterizing the CGM across multiple ionization states, focusing on the O VI and Ne VIII-probed warm-hot (105-106 K) gas within the halos of our galaxy sample.

76 FR 39081 - Combined Notice of Filings #1

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-05

... Amended LGIA Sentinel Project to be effective 6/24/2011. Filed Date: 06/24/2011. Accession Number....13(a)(2)(iii: OG&E Transmission Revenue Requirement Update to be effective 3/1/2011. Filed Date: 06..., LLC submits tariff filing per 35.13(a)(2)(iii: PJM Queue No. W1-116; Original Service Agreement No...

SAGE III/ISS L1B Solar Event Transmission Data (Native) V5 (g3btb)

Atmospheric Science Data Center

2017-12-21

SAGE III/ISS L1B Solar Event Transmission Data (Native) V5 (g3btb)   Project Title:  ... present Temporal Resolution:  1 file per event File Format:  BINARY Tools:  Earthdata ... Radiation Longwave Radiation Shortwave Radiation Event Tag Event Type Obs Beta Angle Order Data:  ...

SAGE III/ISS L2 Solar Event Species Profiles (HDF-EOS) V5 (g3bssp)

Atmospheric Science Data Center

2017-12-21

SAGE III/ISS L2 Solar Event Species Profiles (HDF-EOS) V5 (g3bssp)   Project ... present Temporal Resolution:  1 file per event File Format:  HDF-4 Tools:  Earthdata ... Radiation Longwave Radiation Shortwave Radiation Event Tag Event Type Obs Beta Angle Order Data:  ...

SAGE III/ISS L2 Lunar Event Species Profiles (HDF-EOS) V5 (g3blsp)

Atmospheric Science Data Center

2018-01-04

SAGE III/ISS L2 Lunar Event Species Profiles (HDF-EOS) V5 (g3blsp)   Project ... present Temporal Resolution:  1 file per event File Format:  HDF-4 Tools:  Earthdata ... Radiation Longwave Radiation Shortwave Radiation Event Tag Event Type Obs Beta Angle Order Data:  ...

Afro-American Curriculum Office and Resource Center. ESEA Title III, Toledo Public Schools, Toledo, Ohio.

ERIC Educational Resources Information Center

Meinke, Dean L.; Glick, I. David

The Afro-American Curriculum Office and Resource Center, funded under Title III of the 1965 Elementary Secondary Education Act, had the general purpose of upgrading the instructional level and the material resources concerning the black American's contributions to this country's past and present life. Although the project was directly administered…

Local Navajo Norms for the Wechsler Intelligence Scale for Children: Third Edition.

ERIC Educational Resources Information Center

Tempest, Phyllis

1998-01-01

A project developed Navajo norms for the Wechsler Intelligence Scale for Children, Third Edition (WISC-III). Urban Navajo students and those who were proficient in English had higher WISC-III verbal scores than rural Navajo students and those who were functional in English. English-language proficiency did not affect scores on nonverbal…

Refinement and Field Test of Evaluation Procedures and Materials for ESEA, Title VII Bilingual Education Projects. Phase III Report.

ERIC Educational Resources Information Center

Lam, Tony C. N.; And Others

This report describes an extensive field test of the Bilingual Education Evaluation System (BEES) used to evaluate local level bilingual education projects. Because such projects will usually not be able to implement a traditional true or quasi-experimental design, BEES employs a "gap-reduction" evaluation design that is easily…

Results of a Survey Software Development Project Management in the U.S. Aerospace Industry. Volume III. Major Problems.

DTIC Science & Technology

1979-12-18

simplifies the staffing of a project and assures the experience is ’ recyclable ’." "Staff or members are considered ’universal experts’. During estimation...impact of changes upon the original system." "Project reviews are typically exercises in trivia ." [Keider, 1974] ____ ,,, , _ 55 "First, [lesson

Social Studies Innovations 1968-1969; A Report of the Social Studies Pilots of the SPEEDIER Project.

ERIC Educational Resources Information Center

Myers, Charles B.

Five pilot programs were selected as vehicles to introduce new social studies curriculum ideas into the 52 school systems served by the project. The objectives of this ESEA Title III project were: 1) to improve social studies instruction and teacher classroom behavior; 2) to increase local educator understanding of the new curriculum; 3) to…

Teaching and Learning with Internet-based Resources. Literacy Leader Fellowship Program Reports, Volume III, Number 2.

ERIC Educational Resources Information Center

Cowles, Susan

1997-01-01

This issue focuses on a project to develop a set of curricular materials using Internet-based resources and the formation of a staff development/project implementation team of instructors. Section 1 provides a project rationale, summary information about findings and lessons learned, and results of needs assessment surveys conducted in Oregon.…

Measurement and Interpretation of Crustal Deformation Rates Associated with Postglacial Rebound

NASA Technical Reports Server (NTRS)

Davis, James L.

1998-01-01

This project involves obtaining GPS measurements in Scandinavia, and using the measurements to estimate the viscosity profile of the Earth's mantle and to correct tide-gauge measurements for the rebound effect. Many aspects of this project have been reported in the literature (see Section III). In Section II, we report on the primary geodetic results from this project.

Project Talented and Gifted, End of Grant Report. (ESEA Title III) Appendix IV: Part 2 of Two Bindings.

ERIC Educational Resources Information Center

1977

Presented is a collection of instructional program units, or mini-workshops, developed by the coordinators and resource personnel working in Project Talented and Gifted and used by students participating in the project at the elementary and secondary level. Sections on each topic usually cover objectives and outlines of each session in the…

47 CFR 90.548 - Interoperability Technical Standards.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Specification—New Technology Standards Project—Digital Radio Technical Standards, approved March 2005. (v) ANSI/TIA-102.BAEE-B-2010, Project 25 Radio Management Protocols—New Technology Standards Project—Digital... 2003. (iii) ANSI/TIA-102.BAEA-B-2012, Project 25 Data Overview—New Technology Standards Project—Digital...

77 FR 31610 - FFP Project 110, LLC; Notice of Preliminary Permit Application Accepted for Filing and Soliciting...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-29

.... The project would have an estimated annual generation of 56 gigawatt-hours. Applicant Contact: Ms... electronically via the Internet. See 18 CFR 385.2001(a)(1)(iii) and the instructions on the Commission's Web site...

7 CFR 650.12 - NRCS decisionmaking.

Code of Federal Regulations, 2012 CFR

2012-01-01

.... NRCS provides technical and financial assistance for projects under the Watershed Protection and Flood... are as follows: (1) For Watershed Protection and Flood Prevention projects: (i) Application for... comment is solicited. A decision is made to stop planning assistance or to develop a watershed plan. (iii...

7 CFR 650.12 - NRCS decisionmaking.

Code of Federal Regulations, 2013 CFR

2013-01-01

.... NRCS provides technical and financial assistance for projects under the Watershed Protection and Flood... are as follows: (1) For Watershed Protection and Flood Prevention projects: (i) Application for... comment is solicited. A decision is made to stop planning assistance or to develop a watershed plan. (iii...

7 CFR 650.12 - NRCS decisionmaking.

Code of Federal Regulations, 2011 CFR

2011-01-01

.... NRCS provides technical and financial assistance for projects under the Watershed Protection and Flood... are as follows: (1) For Watershed Protection and Flood Prevention projects: (i) Application for... comment is solicited. A decision is made to stop planning assistance or to develop a watershed plan. (iii...

7 CFR 650.12 - NRCS decisionmaking.

Code of Federal Regulations, 2014 CFR

2014-01-01

.... NRCS provides technical and financial assistance for projects under the Watershed Protection and Flood... are as follows: (1) For Watershed Protection and Flood Prevention projects: (i) Application for... comment is solicited. A decision is made to stop planning assistance or to develop a watershed plan. (iii...

18 CFR 12.35 - Specific inspection requirements.

Code of Federal Regulations, 2013 CFR

2013-04-01

...) Seismicity; (ix) Internal stress and hydrostatic pressures in project structures or their foundations or... structures; (iii) The structural adequacy and stability of structures under all credible loading conditions... project works to withstand the loading or overtopping which may occur from a flood up to the probable...

18 CFR 12.35 - Specific inspection requirements.

Code of Federal Regulations, 2012 CFR

2012-04-01

...) Seismicity; (ix) Internal stress and hydrostatic pressures in project structures or their foundations or... structures; (iii) The structural adequacy and stability of structures under all credible loading conditions... project works to withstand the loading or overtopping which may occur from a flood up to the probable...

75 FR 60066 - Ashley Resource Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-29

... Title III funding and proposals, capture and record preliminary project ideas and receive public comment... open to the public. The following business will be conducted: (1) Welcome and roll call; (2) Approval... papers received; (5) Discussion of preliminary project ideas; (6) Review of next meeting purpose...

36 CFR Appendix A to Part 1234 - Minimum Security Standards for Level III Federal Facilities

Code of Federal Regulations, 2014 CFR

2014-07-01

... technology and blast standards. Immediate review of ongoing projects may generate savings in the... critical systems (alarm systems, radio communications, computer facilities, etc.) Required. Occupant... all exterior windows (shatter protection) Recommended. Review current projects for blast standards...

36 CFR Appendix A to Part 1234 - Minimum Security Standards for Level III Federal Facilities

Code of Federal Regulations, 2013 CFR

2013-07-01

... construction projects should be reviewed if possible, to incorporate current technology and blast standards... critical systems (alarm systems, radio communications, computer facilities, etc.) Required. Occupant... all exterior windows (shatter protection) Recommended. Review current projects for blast standards...

36 CFR Appendix A to Part 1234 - Minimum Security Standards for Level III Federal Facilities

Code of Federal Regulations, 2012 CFR

2012-07-01

... technology and blast standards. Immediate review of ongoing projects may generate savings in the... critical systems (alarm systems, radio communications, computer facilities, etc.) Required. Occupant... all exterior windows (shatter protection) Recommended. Review current projects for blast standards...

Sonic hedgehog expression in corticofugal projection neurons directs cortical microcircuit formation.

PubMed

Harwell, Corey C; Parker, Philip R L; Gee, Steven M; Okada, Ami; McConnell, Susan K; Kreitzer, Anatol C; Kriegstein, Arnold R

2012-03-22

The precise connectivity of inputs and outputs is critical for cerebral cortex function; however, the cellular mechanisms that establish these connections are poorly understood. Here, we show that the secreted molecule Sonic Hedgehog (Shh) is involved in synapse formation of a specific cortical circuit. Shh is expressed in layer V corticofugal projection neurons and the Shh receptor, Brother of CDO (Boc), is expressed in local and callosal projection neurons of layer II/III that synapse onto the subcortical projection neurons. Layer V neurons of mice lacking functional Shh exhibit decreased synapses. Conversely, the loss of functional Boc leads to a reduction in the strength of synaptic connections onto layer Vb, but not layer II/III, pyramidal neurons. These results demonstrate that Shh is expressed in postsynaptic target cells while Boc is expressed in a complementary population of presynaptic input neurons, and they function to guide the formation of cortical microcircuitry. Copyright © 2012 Elsevier Inc. All rights reserved.

Reactive oxygen species and associated reactivity of peroxymonosulfate activated by soluble iron species

NASA Astrophysics Data System (ADS)

Watts, Richard J.; Yu, Miao; Teel, Amy L.

2017-10-01

The activation of peroxymonosulfate by iron (II), iron (III), and iron (III)-EDTA for in situ chemical oxidation (ISCO) was compared using nitrobenzene as a hydroxyl radical probe, anisole as a hydroxyl radical + sulfate radical probe, and hexachloroethane as a reductant + nucleophile probe. In addition, activated peroxymonosulfate was investigated for the treatment of the model groundwater contaminants perchloroethylene (PCE) and trichloroethylene (TCE). The relative activities of hydroxyl radical and sulfate radical in the degradation of the probe compounds and PCE and TCE were isolated using the radical scavengers tert-butanol and isopropanol. Iron (II), iron (III), and iron (III)-EDTA effectively activated peroxymonosulfate to generate hydroxyl radical and sulfate radical, but only a minimal flux of reductants or nucleophiles. Iron (III)-EDTA was a more effective activator than iron (II) and iron (III), and also provided a non-hydroxyl radical, non-sulfate radical degradation pathway. The contribution of sulfate radical relative to hydroxyl radical followed the order of anisole > > TCE > PCE > > nitrobenzene; i.e., sulfate radical was less dominant in the oxidation of more oxidized target compounds. Sulfate radical is often assumed to be the primary oxidant in activated peroxymonosulfate and persulfate systems, but the results of this research demonstrate that the reactivity of sulfate radical with the target compound must be considered before drawing such a conclusion.

Controllable production of low molecular weight heparins by combinations of heparinase I/II/III.

PubMed

Wu, Jingjun; Zhang, Chong; Mei, Xiang; Li, Ye; Xing, Xin-Hui

2014-01-30

Enzymatic depolymerization of heparin by heparinases is promising for production of low molecular weight heparins (LMWHs) as anticoagulants, due to its mild reaction conditions and high selectivity. Here, different heparinase combinations were used to depolymerize heparin. Heparinase I and heparinase II can depolymerize heparin more efficiently than heparinase III, respectively, but heparinase III was the best able to protect the anticoagulant activities of LMWHs. Heparinase III and heparinase I/II combinations were able to efficiently depolymerize heparin to LMWHs with higher anticoagulant activity than the LMWHs produced by the respective heparinase I and heparinase II. HepIII and HepI is the best combination for maintaining high anti-IIa activity (75.7 ± 4.21 IU/mg) at the same Mw value. Furthermore, considering both the changes in molecular weight and anticoagulant activity, the action patterns of heparinase I and heparinase II were found not to follow the exolytic and processive depolymerizing mechanism from the reducing end of heparin. Copyright © 2013 Elsevier Ltd. All rights reserved.

Correlating Oxygen Evolution Catalysts Activity and Electronic Structure by a High-Throughput Investigation of Ni1-y-zFeyCrzOx

PubMed Central

Schwanke, Christoph; Stein, Helge Sören; Xi, Lifei; Sliozberg, Kirill; Schuhmann, Wolfgang; Ludwig, Alfred; Lange, Kathrin M.

2017-01-01

High-throughput characterization by soft X-ray absorption spectroscopy (XAS) and electrochemical characterization is used to establish a correlation between electronic structure and catalytic activity of oxygen evolution reaction (OER) catalysts. As a model system a quasi-ternary materials library of Ni1-y-zFeyCrzOx was synthesized by combinatorial reactive magnetron sputtering, characterized by XAS, and an automated scanning droplet cell. The presence of Cr was found to increase the OER activity in the investigated compositional range. The electronic structure of NiII and CrIII remains unchanged over the investigated composition spread. At the Fe L-edge a linear combination of two spectra was observed. These spectra were assigned to FeIII in Oh symmetry and FeIII in Td symmetry. The ratio of FeIII Oh to FeIII Td increases with the amount of Cr and a correlation between the presence of the FeIII Oh and a high OER activity is found. PMID:28287134

Correlating Oxygen Evolution Catalysts Activity and Electronic Structure by a High-Throughput Investigation of Ni1-y-zFeyCrzOx

NASA Astrophysics Data System (ADS)

Schwanke, Christoph; Stein, Helge Sören; Xi, Lifei; Sliozberg, Kirill; Schuhmann, Wolfgang; Ludwig, Alfred; Lange, Kathrin M.

2017-03-01

High-throughput characterization by soft X-ray absorption spectroscopy (XAS) and electrochemical characterization is used to establish a correlation between electronic structure and catalytic activity of oxygen evolution reaction (OER) catalysts. As a model system a quasi-ternary materials library of Ni1-y-zFeyCrzOx was synthesized by combinatorial reactive magnetron sputtering, characterized by XAS, and an automated scanning droplet cell. The presence of Cr was found to increase the OER activity in the investigated compositional range. The electronic structure of NiII and CrIII remains unchanged over the investigated composition spread. At the Fe L-edge a linear combination of two spectra was observed. These spectra were assigned to FeIII in Oh symmetry and FeIII in Td symmetry. The ratio of FeIII Oh to FeIII Td increases with the amount of Cr and a correlation between the presence of the FeIII Oh and a high OER activity is found.

7 CFR 785.7 - Distribution of Federal grant funds.

Code of Federal Regulations, 2010 CFR

2010-01-01

... mediation services (historical and projected); (2) Scope of mediation services; (3) Service record of the... mediation services, historical and projected, as applicable; (iii) Number of mediations resulting in signed... of mediation; (4) Historic use of program funds (budgeted versus actual); and (5) Material changes in...

Project SERAPHIM Report.

ERIC Educational Resources Information Center

Moore, John W.

1983-01-01

Lists and briefly describes computer programs recently added to those currently available from Project SERAPHIM. Program name, subject, hardware, author, supplier, and cost are provided in separate listings for Apple, PET, TRS-80 I or III, IBM, VIC-20, TERAK, and PDP-11 microcomputers. Includes corrections for two current Apple programs. (JN)

40 CFR 52.2223 - Compliance schedules.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., 1974: Submit to the Administrator a projection of the amount of fuel, by types, that will be... projected above. (iii) April 30, 1974: Submit a statement as to whether boiler modifications will be required. If modifications will be required, submit plans for such modifications. (iv) May 31, 1974: Let...

Planning for Project Continuation.

ERIC Educational Resources Information Center

Berry, Grant, Jr.

Designed to help colleges plan for the successful continuation of educational improvement projects beyond the end of their original funding period, this report presents a case study of Pennsylvania College of Technology's (PCT's) efforts to ensure the continuation of a Title III faculty development program. After describing the the Title III…

7 CFR 1709.117 - Application requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... project including target community, goals, tasks to be completed and other relevant information that... to support a finding of technical feasibility; (ii) Identify the major tasks to be performed and a proposed timeline for completion of each task; and (iii) Identify the location of the project target area...

12 CFR 1291.7 - Monitoring.

Code of Federal Regulations, 2011 CFR

2011-01-01

...' discretion. (iii) Risk factors and other monitoring—(A) Risk factors; other monitoring. A Bank's written monitoring policies shall take into account risk factors such as the amount of AHP subsidy in the project... reasonable risk-based sampling plan to review the back-up project documentation. (2) Reliance on long-term...

12 CFR 1291.7 - Monitoring.

Code of Federal Regulations, 2010 CFR

2010-01-01

...' discretion. (iii) Risk factors and other monitoring—(A) Risk factors; other monitoring. A Bank's written monitoring policies shall take into account risk factors such as the amount of AHP subsidy in the project... reasonable risk-based sampling plan to review the back-up project documentation. (2) Reliance on long-term...

13 CFR 125.2 - Prime contracting assistance.

Code of Federal Regulations, 2013 CFR

2013-01-01

... participation unlikely; (ii) Seeks to package or consolidate discrete construction projects; or (iii) Meets the... participation unlikely, or if a proposed procurement for construction seeks to package or consolidate discrete... discrete projects. (5) In conjunction with their duties to promote the set-aside of procurements for small...

13 CFR 125.2 - Prime contracting assistance.

Code of Federal Regulations, 2012 CFR

2012-01-01

... participation unlikely; (ii) Seeks to package or consolidate discrete construction projects; or (iii) Meets the... participation unlikely, or if a proposed procurement for construction seeks to package or consolidate discrete... discrete projects. (5) In conjunction with their duties to promote the set-aside of procurements for small...

13 CFR 125.2 - Prime contracting assistance.

Code of Federal Regulations, 2011 CFR

2011-01-01

... participation unlikely; (ii) Seeks to package or consolidate discrete construction projects; or (iii) Meets the... participation unlikely, or if a proposed procurement for construction seeks to package or consolidate discrete... discrete projects. (5) In conjunction with their duties to promote the set-aside of procurements for small...

Kaleidoscope 2; A Descriptive Collection of Promising Educational Practices.

ERIC Educational Resources Information Center

MacAdam, Phyllis A.; Fuller, Elisabeth

This issue of Kaleidoscope, which focuses on projects involving innovative educational change funded under ESEA Title III, describes 60 programs in both elementary and secondary schools in Massachusetts. The projects cover a wide range of educational interests including: curriculum development, environmental education, individualized instruction,…

Neurofilament protein is differentially distributed in subpopulations of corticocortical projection neurons in the macaque monkey visual pathways

NASA Technical Reports Server (NTRS)

Hof, P. R.; Ungerleider, L. G.; Webster, M. J.; Gattass, R.; Adams, M. M.; Sailstad, C. A.; Morrison, J. H.; Bloom, F. E. (Principal Investigator)

1996-01-01

Previous studies of the primate cerebral cortex have shown that neurofilament protein is present in pyramidal neuron subpopulations displaying specific regional and laminar distribution patterns. In order to characterize further the neurochemical phenotype of the neurons furnishing feedforward and feedback pathways in the visual cortex of the macaque monkey, we performed an analysis of the distribution of neurofilament protein in corticocortical projection neurons in areas V1, V2, V3, V3A, V4, and MT. Injections of the retrogradely transported dyes Fast Blue and Diamidino Yellow were placed within areas V4 and MT, or in areas V1 and V2, in 14 adult rhesus monkeys, and the brains of these animals were processed for immunohistochemistry with an antibody to nonphosphorylated epitopes of the medium and heavy molecular weight subunits of the neurofilament protein. Overall, there was a higher proportion of neurons projecting from areas V1, V2, V3, and V3A to area MT that were neurofilament protein-immunoreactive (57-100%), than to area V4 (25-36%). In contrast, feedback projections from areas MT, V4, and V3 exhibited a more consistent proportion of neurofilament protein-containing neurons (70-80%), regardless of their target areas (V1 or V2). In addition, the vast majority of feedback neurons projecting to areas V1 and V2 were located in layers V and VI in areas V4 and MT, while they were observed in both supragranular and infragranular layers in area V3. The laminar distribution of feedforward projecting neurons was heterogeneous. In area V1, Meynert and layer IVB cells were found to project to area MT, while neurons projecting to area V4 were particularly dense in layer III within the foveal representation. In area V2, almost all neurons projecting to areas MT or V4 were located in layer III, whereas they were found in both layers II-III and V-VI in areas V3 and V3A. These results suggest that neurofilament protein identifies particular subpopulations of corticocortically projecting neurons with distinct regional and laminar distribution in the monkey visual system. It is possible that the preferential distribution of neurofilament protein within feedforward connections to area MT and all feedback projections is related to other distinctive properties of these corticocortical projection neurons.

Simian Virus 40 Large T Antigen Interacts with Human TFIIB-Related Factor and Small Nuclear RNA-Activating Protein Complex for Transcriptional Activation of TATA-Containing Polymerase III Promoters

PubMed Central

Damania, Blossom; Mital, Renu; Alwine, James C.

1998-01-01

The TATA-binding protein (TBP) is common to the basal transcription factors of all three RNA polymerases, being associated with polymerase-specific TBP-associated factors (TAFs). Simian virus 40 large T antigen has previously been shown to interact with the TBP-TAFII complexes, TFIID (B. Damania and J. C. Alwine, Genes Dev. 10:1369–1381, 1996), and the TBP-TAFI complex, SL1 (W. Zhai, J. Tuan, and L. Comai, Genes Dev. 11:1605–1617, 1997), and in both cases these interactions are critical for transcriptional activation. We show a similar mechanism for activation of the class 3 polymerase III (pol III) promoter for the U6 RNA gene. Large T antigen can activate this promoter, which contains a TATA box and an upstream proximal sequence element but cannot activate the TATA-less, intragenic VAI promoter (a class 2, pol III promoter). Mutants of large T antigen that cannot activate pol II promoters also fail to activate the U6 promoter. We provide evidence that large T antigen can interact with the TBP-containing pol III transcription factor human TFIIB-related factor (hBRF), as well as with at least two of the three TAFs in the pol III-specific small nuclear RNA-activating protein complex (SNAPc). In addition, we demonstrate that large T antigen can cofractionate and coimmunoprecipitate with the hBRF-containing complex TFIIIB derived from HeLa cells infected with a recombinant adenovirus which expresses large T antigen. Hence, similar to its function with pol I and pol II promoters, large T antigen interacts with TBP-containing, basal pol III transcription factors and appears to perform a TAF-like function. PMID:9488448

Biotransformation of arsenic species by activated sludge and removal of bio-oxidised arsenate from wastewater by coagulation with ferric chloride.

PubMed

Andrianisa, Harinaivo Anderson; Ito, Ayumi; Sasaki, Atsushi; Aizawa, Jiro; Umita, Teruyuki

2008-12-01

The potential of activated sludge to catalyse bio-oxidation of arsenite [As(III)] to arsenate [As(V)] and bio-reduction of As(V) to As(III) was investigated. In batch experiments (pH 7, 25 degrees C) using activated sludge taken from a treatment plant receiving municipal wastewater non-contaminated with As, As(III) and As(V) were rapidly biotransformed to As(V) under aerobic condition and As(III) under anaerobic one without acclimatisation, respectively. Sub-culture of the activated sludge using a minimal liquid medium containing 100mg As(III)/L and no organic carbon source showed that aerobic arsenic-resistant bacteria were present in the activated sludge and one of the isolated bacteria was able to chemoautotrophically oxidise As(III) to As(V). Analysis of arsenic species in a full-scale oxidation ditch plant receiving As-contaminated wastewater revealed that both As(III) and As(V) were present in the influent, As(III) was almost completely oxidised to As(V) after supply of oxygen by the aerator in the oxidation ditch, As(V) oxidised was reduced to As(III) in the anaerobic zone in the ditch and in the return sludge pipe, and As(V) was the dominant species in the effluent. Furthermore, co-precipitation of As(V) bio-oxidised by activated sludge in the plant with ferric hydroxide was assessed by jar tests. It was shown that the addition of ferric chloride to mixed liquor as well as effluent achieved high removal efficiencies (>95%) of As and could decrease the residual total As concentrations in the supernatant from about 200 microg/L to less than 5 microg/L. It was concluded that a treatment process combining bio-oxidation with activated sludge and coagulation with ferric chloride could be applied as an alternative technology to treat As-contaminated wastewater.

Interdependent genotoxic mechanisms of monomethylarsonous acid: Role of ROS-induced DNA damage and poly(ADP-ribose) polymerase-1 inhibition in the malignant transformation of urothelial cells

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wnek, Shawn M.; Kuhlman, Christopher L.; Camarillo, Jeannie M.

2011-11-15

Exposure of human bladder urothelial cells (UROtsa) to 50 nM of the arsenic metabolite, monomethylarsonous acid (MMA{sup III}), for 12 weeks results in irreversible malignant transformation. The ability of continuous, low-level MMA{sup III} exposure to cause an increase in genotoxic potential by inhibiting repair processes necessary to maintain genomic stability is unknown. Following genomic insult within cellular systems poly(ADP-ribose) polymerase-1 (PARP-1), a zinc finger protein, is rapidly activated and recruited to sites of DNA strand breaks. When UROtsa cells are continuously exposed to 50 nM MMA{sup III}, PARP-1 activity does not increase despite the increase in MMA{sup III}-induced DNA single-strandmore » breaks through 12 weeks of exposure. When UROtsa cells are removed from continuous MMA{sup III} exposure (2 weeks), PARP-1 activity increases coinciding with a subsequent decrease in DNA damage levels. Paradoxically, PARP-1 mRNA expression and protein levels are elevated in the presence of continuous MMA{sup III} indicating a possible mechanism to compensate for the inhibition of PARP-1 activity in the presence of MMA{sup III}. The zinc finger domains of PARP-1 contain vicinal sulfhydryl groups which may act as a potential site for MMA{sup III} to bind, displace zinc ion, and render PARP-1 inactive. Mass spectrometry analysis demonstrates the ability of MMA{sup III} to bind a synthetic peptide representing the zinc-finger domain of PARP-1, and displace zinc from the peptide in a dose-dependent manner. In the presence of continuous MMA{sup III} exposure, continuous 4-week zinc supplementation restored PARP-1 activity levels and reduced the genotoxicity associated with MMA{sup III}. Zinc supplementation did not produce an overall increase in PARP-1 protein levels, decrease the levels of MMA{sup III}-induced reactive oxygen species, or alter Cu-Zn superoxide dismutase levels. Overall, these results present two potential interdependent mechanisms in which MMA{sup III} may increase the susceptibility of UROtsa cells to genotoxic insult and/or malignant transformation: elevated levels of MMA{sup III}-induced DNA damage through the production of reactive oxygen species, and the direct MMA{sup III}-induced inhibition of PARP-1.« less

The Design and Implementation of a Model Evaluation Capability. 1975-76 Final Report. Title III Project.

ERIC Educational Resources Information Center

Austin Independent School District, TX. Office of Research and Evaluation.

The Austin Independent School District received an Elementary and Secondary Education Act Title III grant in 1973 to develop an internal research and evaluation capability. Funding was provided the resulting Office of Research and Evaluation (ORE) for three years. The foci of the original grant were (1) to develop a district evaluation model, (2)…

Pima Cultural Background Materials for an Elementary and Secondary Education Act Title III Project.

ERIC Educational Resources Information Center

Brook, Weston L., Comp.; And Others

Produced with funds under Title III of the Elementary and Secondary Education Act, this unit on Pima cultural background and Middle American civilization was designed to help Pima students achieve a sense of identity and pride in their Indian background by (1) thinking of themselves as a people with a long history and (2) learning that their…

SAGE III/ISS L1B Solar Event Transmission Data (HDF-EOS) V5 (g3bt)

Atmospheric Science Data Center

2017-12-21

SAGE III/ISS L1B Solar Event Transmission Data (HDF-EOS) V5 (g3bt)   Project Title:  ... present Temporal Resolution:  1 file per event File Format:  HDF-4 Tools:  Earthdata ... Radiation Longwave Radiation Shortwave Radiation Event Tag Event Type Obs Beta Angle Order Data:  ...

Family welfare and health practices increase after exposure to population education.

PubMed

1994-01-01

Since 1987, the State Resource Center of Jamia Millia Islamia of New Delhi has been implementing a program which integrates population education contents into its literacy education classes for adult learners. Using the core messages on family size, spacing of children, responsible parenthood, right age of marriage, population-related beliefs and customs and population and development, the Center undertook many activities such as: i) integrating population contents in literacy primers, readers and supplementary reading books; ii) development of teaching aids and instructor's resource materials; iii) organization of training for instructors and iv) holding outreach activities such as street corner plays, fairs, etc. To evaluate the impact of the program, the Center undertook an impact survey to measure the level of knowledge, attitude and practices of randomly selected beneficiaries of the project, i.e. 934 learners from 85 literacy learning centers, 5 years after the introduction of the population education program. The study used pre-test and post-test method for collecting data and to compare results. In terms of practice, the study has shown that the respondents having knowledge about family planning methods increased from 67 to 87%, after being exposed to the project's activities. There was also an increase of 61% in cases adopting family planning methods over the pre-measurement level. More importantly, there was not only an increase in awareness of public health and family welfare services but a 137% increase was registered in the use of public health and family welfare facilities for family planning counseling and services. With regard to knowledge and attitude on the various population education messages promoted by the project, the study has shown a 40% increase in "high" knowledge category and 25% increase in favorable attitude after the exposure to the project. full text

The After Breast Cancer Pooling Project: rationale, methodology, and breast cancer survivor characteristics.

PubMed

Nechuta, Sarah J; Caan, Bette J; Chen, Wendy Y; Flatt, Shirley W; Lu, Wei; Patterson, Ruth E; Poole, Elizabeth M; Kwan, Marilyn L; Chen, Zhi; Weltzien, Erin; Pierce, John P; Shu, Xiao Ou

2011-09-01

The After Breast Cancer Pooling Project was established to examine the role of physical activity, adiposity, dietary factors, supplement use, and quality of life (QOL) in breast cancer prognosis. This paper presents pooled and harmonized data on post-diagnosis lifestyle factors, clinical prognostic factors, and breast cancer outcomes from four prospective cohorts of breast cancer survivors (three US-based and one from Shanghai, China) for 18,314 invasive breast cancer cases diagnosed between 1976 and 2006. Most participants were diagnosed with stage I-II breast cancer (84.7%). About 60% of breast tumors were estrogen receptor (ER)+/progesterone receptor (PR)+; 21% were ER-/PR-. Among 8,118 participants with information on HER-2 tumor status, 74.8% were HER-2- and 18.5% were HER-2+. At 1-2 years post-diagnosis (on average), 17.9% of participants were obese (BMI ≥ 30 kg/m2), 32.6% were overweight (BMI 25-29 kg/m2), and 59.9% met the 2008 Physical Activity Guidelines for Americans (≥ 2.5 h per week of moderate activity). During follow-up (mean = 8.4 years), 3,736 deaths (2,614 from breast cancer) and 3,564 recurrences have been documented. After accounting for differences in year of diagnosis and timing of post-diagnosis enrollment, five-year overall survival estimates were similar across cohorts. This pooling project of 18,000 breast cancer survivors enables the evaluation of associations of post-diagnosis lifestyle factors, QOL, and breast cancer outcomes with an adequate sample size for investigation of heterogeneity by hormone receptor status and other clinical predictors. The project sets the stage for international collaborations for the investigation of modifiable predictors for breast cancer outcomes.

Enhanced degradation of trichloroethene by calcium peroxide activated with Fe(III) in the presence of citric acid

PubMed Central

ZHANG, Xiang; GU, Xiaogang; LU, Shuguang; MIAO, Zhouwei; XU, Minhui; FU, Xiaori; DANISH, Muhammad; Brusseau, Mark L.; QIU, Zhaofu; SUI, Qian

2017-01-01

Trichloroethene (TCE) degradation by Fe(III)-activated calcium peroxide (CP) in the presence of citric acid (CA) in aqueous solution was investigated. The results demonstrated that the presence of CA enhanced TCE degradation significantly by increasing the concentration of soluble Fe(III) and promoting H2O2 generation. The generation of HO• and O2−• in both the CP/Fe(III) and CP/Fe(III)/CA systems was confirmed with chemical probes. The results of radical scavenging tests showed that TCE degradation was due predominantly o direct oxidation by HO•, while O2−• strengthened the generation of HO• by promoting Fe(III) transformation in the CP/Fe(III)/CA system. Acidic pH conditions were favorable for TCE degradation, and the TCE degradation rate decreased with increasing pH. The presence of Cl−, HCO3−, and humic acid (HA) inhibited TCE degradation to different extents for the CP/Fe(III)/CA system. Analysis of Cl− production suggested that TCE degradation in the CP/Fe(III)/CA system occurred through a dechlorination process. In summary, this study provided detailed information for the application of CA-enhanced Fe(III)-activated calcium peroxide for treating TCE contaminated groundwater. PMID:28959499

Photoinduced Cobalt(III)-Trifluoromethyl Bond Activation Enables Arene C-H Trifluoromethylation.

PubMed

Harris, Caleb F; Kuehner, Christopher S; Bacsa, John; Soper, Jake D

2018-01-26

Visible-light capture activates a thermodynamically inert Co III -CF 3 bond for direct C-H trifluoromethylation of arenes and heteroarenes. New trifluoromethylcobalt(III) complexes supported by a redox-active [OCO] pincer ligand were prepared. Coordinating solvents, such as MeCN, afford green, quasi-octahedral [( S OCO)Co III (CF 3 )(MeCN) 2 ] (2), but in non-coordinating solvents the complex is red, square pyramidal [( S OCO)Co III (CF 3 )(MeCN)] (3). Both are thermally stable, and 2 is stable in light. But exposure of 3 to low-energy light results in facile homolysis of the Co III -CF 3 bond, releasing . CF 3 radical, which is efficiently trapped by TEMPO . or (hetero)arenes. The homolytic aromatic substitution reactions do not require a sacrificial or substrate-derived oxidant because the Co II by-product of Co III -CF 3 homolysis produces H 2 . The photophysical properties of 2 and 3 provide a rationale for the disparate light stability. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Evaluation of the Field Test of Project Information Packages: Volume III--Resource Cost Analysis.

ERIC Educational Resources Information Center

Al-Salam, Nabeel; And Others

The third of three volumes evaluating the first year field test of the Project Information Packages (PIPs) provides a cost analysis study as a key element in the total evaluation. The resource approach to cost analysis is explained and the specific resource methodology used in the main cost analysis of the 19 PIP field-test projects detailed. The…

Activities of natural methyl farnesoids on pupariation and metamorphosis of Drosophila melanogaster

USDA-ARS?s Scientific Manuscript database

Methyl farnesoate (MF) and juvenile hormone (JH III), which respectively bind to the receptors USP and MET, and bisepoxy JH III (bisJHIII) were assessed for several activities during Drosophila larval development, and during prepupal development to eclosed adults. Dietary MF and JH III were similar...

Synthesis and spectroscopic studies of biologically active compounds derived from oxalyldihydrazide and benzil, and their Cr(III), Fe(III) and Mn(III) complexes.

PubMed

Singh, D P; Kumar, Ramesh; Singh, Jitender

2009-04-01

A new series of complexes have been synthesized by template condensation of oxalyldihydrazide and benzil in methanolic medium in the presence of trivalent chromium, manganese and iron salts forming complexes of the type [M(C(32)H(24)N(8)O(4))X]X(2) where M = Cr(III), Mn(III), Fe(III) and X = Cl(-1), NO(3)(-1), CH(3)COO(-1). The complexes have been characterized with the help of elemental analyses, conductance measurements, magnetic susceptibility measurements, electronic, NMR, infrared and far infrared spectral studies. On the basis of these studies, a five coordinate square pyramidal geometry has been proposed for all these complexes. The biological activities of the metal complexes have been tested in vitro against a number of pathogenic bacteria to assess their inhibiting potential. Some of these complexes have been found to exhibit remarkable antibacterial activities.

Phase III (final) evaluation report : national evaluation of the FY01 earmark, area transportation authority of North Central Pennsylvania--regional GIS/ITS initiative.

DOT National Transportation Integrated Search

2009-08-31

This report presents the results of the United States Department of Transportation evaluation of a federally funded earmark project implemented by the Area Transportation Authority of North Central Pennsylvania (ATA). The project implemented a suite ...

NASA Pathways: Intern Employment Program Work Report Summer 2014

NASA Technical Reports Server (NTRS)

Davidson, Kyle B.

2014-01-01

This report documents the work experience and project involvement of Kyle Davidson during his tenure at Kennedy Space Center for the summer of 2014. Projects include the Nitrogen Oxygen Recharge System (NORS), Restore satellite servicing program, and mechanical handling operations for the SAGE III and Rapidscat payloads.

Multihandicapped Blind. Final Project Report.

ERIC Educational Resources Information Center

Jones, Lloyd

The final report of the Garden Grove unified school district project for 1969 through 1972 (funded through Title III) involving six multiply handicapped, legally blind children, 7- to 10-years-old, who were previously excluded from special education (SE) classes is presented. Described as the main procedural objective is development of a…

78 FR 59666 - Transmission Infrastructure Program; Proposed Transmission Infrastructure Program Updates and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-27

... Loan Programs Office into the process. The FRN also identifies the principles Western will continue using to ensure (1) that the Program is separate and distinct from Western's power marketing functions... obtain project funding. Table of Contents I. Definitions II. Principles III. Project Evaluation Criteria...

7 CFR 3560.460 - Double damages.

Code of Federal Regulations, 2010 CFR

2010-01-01

... reasonable operating expense or necessary repair of the project or for which the documentation has not been... this section; and (iii) Any officer, director, or partner of an entity that borrows funds in accordance... and income of the project that the court determines to have been used in violation of the provisions...

40 CFR 86.416-80 - Application for certification.

Code of Federal Regulations, 2010 CFR

2010-07-01

.... (a) New motorcycles produced by a manufacturer whose projected sales in the United States is 10,000... range of available fuel and ignition system adjustments. (iii) Projected U.S. sales data sufficient to... requested. If reduced testing based on low sales volume is requested the method of predicting sales shall be...

34 CFR 664.31 - What selection criteria does the Secretary use?

Code of Federal Regulations, 2013 CFR

2013-07-01

... foreign languages and area studies. (iii) The extent to which direct experience abroad is necessary to... POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION FULBRIGHT-HAYS GROUP PROJECTS ABROAD PROGRAM How Does the... Fulbright Foreign Scholarship Board Group Projects Abroad for funding under this part. (a) Plan of operation...

34 CFR 664.31 - What selection criteria does the Secretary use?

Code of Federal Regulations, 2012 CFR

2012-07-01

... foreign languages and area studies. (iii) The extent to which direct experience abroad is necessary to... POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION FULBRIGHT-HAYS GROUP PROJECTS ABROAD PROGRAM How Does the... Fulbright Foreign Scholarship Board Group Projects Abroad for funding under this part. (a) Plan of operation...

34 CFR 664.31 - What selection criteria does the Secretary use?

Code of Federal Regulations, 2014 CFR

2014-07-01

... foreign languages and area studies. (iii) The extent to which direct experience abroad is necessary to... POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION FULBRIGHT-HAYS GROUP PROJECTS ABROAD PROGRAM How Does the... Fulbright Foreign Scholarship Board Group Projects Abroad for funding under this part. (a) Plan of operation...

34 CFR 664.31 - What selection criteria does the Secretary use?

Code of Federal Regulations, 2011 CFR

2011-07-01

... foreign languages and area studies. (iii) The extent to which direct experience abroad is necessary to... POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION FULBRIGHT-HAYS GROUP PROJECTS ABROAD PROGRAM How Does the... Fulbright Foreign Scholarship Board Group Projects Abroad for funding under this part. (a) Plan of operation...

34 CFR 664.31 - What selection criteria does the Secretary use?

Code of Federal Regulations, 2010 CFR

2010-07-01

... foreign languages and area studies. (iii) The extent to which direct experience abroad is necessary to... POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION FULBRIGHT-HAYS GROUP PROJECTS ABROAD PROGRAM How Does the... Fulbright Foreign Scholarship Board Group Projects Abroad for funding under this part. (a) Plan of operation...

ScienceVision: An Inquiry-Based Videodisc Science Curriculum.

ERIC Educational Resources Information Center

Dawson, George

As a result of declining scores, the National Science Foundation has funded numerous materials-development grants. Largest among these is the Interactive Media Science (IMS) Project at Florida State University (FSU) in Tallahassee. This project's mandate is to design, develop, and produce six level III interactive videodisc programs for middle…

How Voting and Consensus Created the Diagnostic and Statistical Manual of Mental Disorders (DSM-III).

PubMed

Davies, James

2017-04-01

This paper examines how Task Force votes were central to the development of Diagnostic and Statistical Manual of Mental Disorders (DSM-III and DSM-III-R). Data were obtained through a literature review, investigation of DSM archival material housed at the American Psychiatric Association (APA), and interviews with key Task Force members of DSM-III and DSM-III-R. Such data indicate that Task Force votes played a central role in the making of DSM-III, from establishing diagnostic criteria and diagnostic definitions to settling questions about the inclusion or removal of diagnostic categories. The paper concludes that while the APA represented DSM-III, and the return to descriptive psychiatry it inaugurated, as a triumph of empirically based decision-making, the evidence presented here fails to support that view. Since the DSM is a cumulative project, and as DSM-III lives on through subsequent editions, this paper calls for a more socio-historically informed understanding of DSM's construction to be deployed in how the DSM is taught and implemented in training and clinical settings.

A Fuzzy Expert System for Fault Management of Water Supply Recovery in the ALSS Project

NASA Technical Reports Server (NTRS)

Tohala, Vapsi J.

1998-01-01

Modeling with a new software is a challenge. CONFIG is a challenge and is design to work with many types of systems in which discrete and continuous processes occur. The CONFIG software was used to model the two subsystem of the Water Recovery system: ICB and TFB. The model worked manually only for water flows with further implementation to be done in the future. Activities in the models are stiff need to be implemented based on testing of the hardware for phase III. More improvements to CONFIG are in progress to make it a more user friendly software.

Reactive oxygen species and associated reactivity of peroxymonosulfate activated by soluble iron species.

PubMed

Watts, Richard J; Yu, Miao; Teel, Amy L

2017-10-01

The activation of peroxymonosulfate by iron (II), iron (III), and iron (III)-EDTA for in situ chemical oxidation (ISCO) was compared using nitrobenzene as a hydroxyl radical probe, anisole as a hydroxyl radical+sulfate radical probe, and hexachloroethane as a reductant+nucleophile probe. In addition, activated peroxymonosulfate was investigated for the treatment of the model groundwater contaminants perchloroethylene (PCE) and trichloroethylene (TCE). The relative activities of hydroxyl radical and sulfate radical in the degradation of the probe compounds and PCE and TCE were isolated using the radical scavengers tert-butanol and isopropanol. Iron (II), iron (III), and iron (III)-EDTA effectively activated peroxymonosulfate to generate hydroxyl radical and sulfate radical, but only a minimal flux of reductants or nucleophiles. Iron (III)-EDTA was a more effective activator than iron (II) and iron (III), and also provided a non-hydroxyl radical, non-sulfate radical degradation pathway. The contribution of sulfate radical relative to hydroxyl radical followed the order of anisole>TCE>PCE >nitrobenzene; i.e., sulfate radical was less dominant in the oxidation of more oxidized target compounds. Sulfate radical is often assumed to be the primary oxidant in activated peroxymonosulfate and persulfate systems, but the results of this research demonstrate that the reactivity of sulfate radical with the target compound must be considered before drawing such a conclusion. Published by Elsevier B.V.

Mechanisms underlying the inhibitory effects of arsenic compounds on protein tyrosine phosphatase (PTP)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rehman, Kanwal; Chen, Zhe; Wang, Wen Wen

2012-09-15

Arsenic binding to biomolecules is considered one of the major toxic mechanisms, which may also be related to the carcinogenic risks of arsenic in humans. At the same time, arsenic is also known to activate the phosphorylation-dependent signaling pathways including the epidermal growth factor receptor, the mitogen-activated protein kinase and insulin/insulin-like growth factor-1 pathways. These signaling pathways originate at the level of receptor tyrosine kinases whose phosphorylation status is regulated by opposing protein tyrosine phosphatase (PTP) activity. Reversible tyrosine phosphorylation, which is governed by the balanced action of protein tyrosine kinases and phosphatases, regulates important signaling pathways that are involvedmore » in the control of cell proliferation, adhesion and migration. In the present study, we have focused on the interaction of cellular PTPs with toxic trivalent arsenite (iAs{sup III}) and its intermediate metabolites such as monomethylarsonous acid (MMA{sup III}) and dimethylarsinous acid (DMA{sup III}) in vitro, and then determined the arsenic binding site in PTP by the use of recombinant PTPs (e.g., PTP1B and CD45). Interestingly, the activities of PTP1B (cytoplasm-form) or CD45 (receptor-linked form) were observed to be strongly inhibited by both methylated metabolites (i.e., MMA{sup III} and DMA{sup III}) but not by iAs{sup III}. Matrix-assisted laser desorption ionization-time-of-flight mass spectrometry (MALDI-TOF MS) has clearly confirmed that the organic intermediate, DMA{sup III} directly bound to the active site cysteine residue of PTP1B (e.g., Cys215), resulting in inhibition of enzyme activity. These results suggest that arsenic exposure may disturb the cellular signaling pathways through PTP inactivation. Highlights: ► This study focused on the interaction of PTPs with trivalent arsenicals in vitro. ► We for the first time confirmed that DMA{sup III} strongly inhibited activity of PTP1B. ► DMA{sup III} directly bound to PTP1B, resulting in inhibition of enzyme activity.« less

Caracterisation des revetements par projection thermique a haute vitesse obtenus a partir de differentes poudres de wc-10co-4cr pour des applications en aeronautique =

NASA Astrophysics Data System (ADS)

Quintero Malpica, Alfonso

Les revetements par projection thermique HVOF (High Velocity Oxy-Fuel) sont communement utilises dans l'industrie aeronautique, notamment au sein du partenaire industriel du projet (Tecnickrome Aeronautique Inc), comme des remplacants pour les revetements produits par l'electrodeposition du chrome dur due aux problemes environnementaux. Ce projet avait pour but de trouver une poudre alternative a celle qui est actuellement utilisee pour la production des revetements de type WC-10Co-4Cr obtenus avec la technologie de projection thermique a haute vitesse HVOF et en utilisant le systeme de projection HVOF-JET KOTERTM III. Dans un premier temps, cinq poudres incluant celle de reference, ayant des distributions granulometriques differentes, ont ete projetees dans le but d'identifier quelles poudres pouvaient etre utilisees avec le systeme de projection HVOF-JET KOTERTM III en gardant des parametres similaires (debit d'hydrogene, debit d'oxygene, debit de poudre et distance de projection) que pour la poudre de reference. Les revetements obtenus a partir des poudres etudiees ont ete evalues selon les criteres d'acceptation des revetements sollicites par les principaux manufacturiers des trains d'atterrissage. Les tests ont porte sur l'epaisseur, l'adhesion, la microstructure, la microdurete, les contraintes residuelles et la rugosite. A partir des resultats obtenus, seulement deux poudres ont rencontre toutes les proprietes demandees par les specifications aeronautiques. L'influence de la variation de la distance de projection sur la qualite des revetements a ete etudiee. Cinq distances (100, 125, 150, 175 et 200 mm) ont ete choisies pour faire la projection des deux poudres selectionnees. Les revetements obtenus ont montre de proprietes des revetements similaires (epaisseur, adhesion, microstructure, microdurete, contraintes residuelles et rugosite). Il a ete trouve que la distance de projection est un parametre indirect du systeme de projection HVOF-JET KOTERTM III et qu'autant la vitesse que la temperature des particules semblent mieux determiner les proprietes du revetement, en particulier, les niveaux de contraintes residuelles finales dans les revetements. Lorsque les revetements sont produits a de courtes distances de projection, les particules arrivent avec plus grande vitesse et temperature ce qui resulte dans de plus grandes temperatures du substrat et plus grande energie d'impact, resultant dans de plus grandes contraintes residuelles de compression dans les revetements.

Hormonal interference with pheromone systems in parasitic acarines, especially ixodid ticks. Annual technical report No. 4, 1 May 1983-30 April 1984

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sonenshine, D.E.; Oliver, J.H. Jr.; Homsher, P.J.

1984-05-01

The most important result of recent project research was the demonstration of the juvenoid JH III by radioimmunoassay. This assay revealed an estimated 78 pg/tick in the hemolymph of partially fed Hyalomma dromedarii females, and an estimated 3 pg/tick in the hemolymph of partially fed D. variabilis. Other studies, especially digestion of tritium labelled JH III, provided additional evidence suggesting the presence of this hormone in adult ticks. The implications of these findings for our understanding of sex pheromone regulation in ticks is discussed. Other studies described in this report deal with the source of ecdysteroid in teh camel tick,more » Hyalomma dromedarii, the American dog tick, Dermacentor variabilis, and the soft tick, Ornithodoros parkeri. Studies done at ODU, using radioimmunoassay high performance liquid chromatography, and autoradiography, provide new evidence implicating the tick synganglion - lateral nerve plexus as an important site of ecdysteroid activity in the ixodid ticks. Other studies with ecdysteriods suggest that metabolism of ecdysone or 20-hydroxyecdysone (or both) to inactive metabolites, possibly including polar conjugates. If confirmed, these findings indicate the presence of only a single active ecdysteriod hormone in ticks, 20-hydroxyecdysone.« less

Saugus River and Tributaries, Lynn, Malden, Revere and Saugus, Massachusetts. Flood Damage Reduction. Volume 7. Appendix J. Feasibility Study and EIS/EIR Comments and Responses. Section A.

DTIC Science & Technology

1989-12-01

project nor affect significantly the projects econmic efficiency. These effects are described in the Feasibility Report, EIS/EIR and suportin...modifications beca necesary. To insure the econmic efficiency of the project using the accelerated rise rate in NRc Case III, the Regional Project was...is a str econmic candidate. 23 Table 14 RICtOALL P3ECr ECONaMEC FEABILIY WI H SEA LEVEL RISE (1988 Price Level) Oticon 3 Historical NRC Project

Energy use in the marine transportation industry: Task III. Efficiency improvements; Task IV. Industry future. Final report, Volume IV. [Projections for year 2000

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

1977-12-01

Tasks III and IV measure the characteristics of potential research and development programs that could be applied to the maritime industry. It was necessary to identify potential operating scenarios for the maritime industry in the year 2000 and determine the energy consumption that would result given those scenarios. After the introductory chapter the operational, regulatory, and vessel-size scenarios for the year 2000 are developed in Chapter II. In Chapter III, future cargo flows and expected levels of energy use for the baseline 2000 projection are determined. In Chapter IV, the research and development programs are introduced into the future USmore » flag fleet and the energy-savings potential associated with each is determined. The first four appendices (A through D) describe each of the generic technologies. The fifth appendix (E) contains the baseline operating and cost parameters against which 15 program areas were evaluated. (MCW)« less

Fusion protein of retinol-binding protein and albumin domain III reduces liver fibrosis

PubMed Central

Lee, Hongsik; Jeong, Hyeyeun; Park, Sangeun; Yoo, Wonbaek; Choi, Soyoung; Choi, Kyungmin; Lee, Min-Goo; Lee, Mihwa; Cha, DaeRyong; Kim, Young-Sik; Han, Jeeyoung; Kim, Wonkon; Park, Sun-Hwa; Oh, Junseo

2015-01-01

Activated hepatic stellate cells (HSCs) play a key role in liver fibrosis, and inactivating HSCs has been considered a promising therapeutic approach. We previously showed that albumin and its derivative designed for stellate cell-targeting, retinol-binding protein–albumin domain III fusion protein (referred to as R-III), inactivate cultured HSCs. Here, we investigated the mechanism of action of albumin/R-III in HSCs and examined the anti-fibrotic potential of R-III in vivo. R-III treatment and albumin expression downregulated retinoic acid (RA) signaling which was involved in HSC activation. RA receptor agonist and retinaldehyde dehydrogenase overexpression abolished the anti-fibrotic effect of R-III and albumin, respectively. R-III uptake into cultured HSCs was significantly decreased by siRNA-STRA6, and injected R-III was localized predominantly in HSCs in liver. Importantly, R-III administration reduced CCl4- and bile duct ligation-induced liver fibrosis. R-III also exhibited a preventive effect against CCl4-inducd liver fibrosis. These findings suggest that the anti-fibrotic effect of albumin/R-III is, at least in part, mediated by downregulation of RA signaling and that R-III is a good candidate as a novel anti-fibrotic drug. PMID:25864124

78 FR 69683 - Agency Information Collection Activities: Submission for OMB Review; Comment Request; OAA Title...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-20

... Collection Activities: Submission for OMB Review; Comment Request; OAA Title III-E Evaluation AGENCY... to Older Americans Act (OAA) Title III-E Evaluation. DATES: Submit written or electronic comments on... information technology. The OAA Title III-E National Family Caregiver Support Program (NFCSP), with statutory...

The xylanase inhibitor TAXI-III counteracts the necrotic activity of a Fusarium graminearum xylanase in vitro and in durum wheat transgenic plants.

PubMed

Moscetti, Ilaria; Faoro, Franco; Moro, Stefano; Sabbadin, Davide; Sella, Luca; Favaron, Francesco; D'Ovidio, Renato

2015-08-01

The xylanase inhibitor TAXI-III has been proven to delay Fusarium head blight (FHB) symptoms caused by Fusarium graminearum in transgenic durum wheat plants. To elucidate the molecular mechanism underlying the capacity of the TAXI-III transgenic plants to limit FHB symptoms, we treated wheat tissues with the xylanase FGSG_03624, hitherto shown to induce cell death and hydrogen peroxide accumulation. Experiments performed on lemmas of flowering wheat spikes and wheat cell suspension cultures demonstrated that pre-incubation of xylanase FGSG_03624 with TAXI-III significantly decreased cell death. Most interestingly, a reduced cell death relative to control non-transgenic plants was also obtained by treating, with the same xylanase, lemmas of TAXI-III transgenic plants. Molecular modelling studies predicted an interaction between the TAXI-III residue H395 and residues E122 and E214 belonging to the active site of xylanase FGSG_03624. These results provide, for the first time, clear indications in vitro and in planta that a xylanase inhibitor can prevent the necrotic activity of a xylanase, and suggest that the reduced FHB symptoms on transgenic TAXI-III plants may be a result not only of the direct inhibition of xylanase activity secreted by the pathogen, but also of the capacity of TAXI-III to avoid host cell death. © 2014 BSPP AND JOHN WILEY & SONS LTD.

A Guide to the Microform Collections of the USMA (United States Military Academy) Library,

DTIC Science & Technology

1983-01-01

array of material about the Manhattan Project and the atomic bombings of Hiroshima and Nagasaki; none of it was declassified until 1976. Foremost among...1946. The twenty-one page printed A Guide to the Manhattan Project : Official History and Documents, located on top of the metal cabinets in Room 212, is...organizational characteristics of the Manhattan Project . The seven succeeding books discussed the 49 various sub-projects of the effort, such as Book III

Radiation Effects in III-V Nanowire Devices

DTIC Science & Technology

2016-09-01

Nanowire Devices Distribution Statement A. Approved for public release; distribution is unlimited. September 2016 HDTRA1-11-1-0021 Steven R...Name: Prof. S. R. J. Brueck Organization/Institution: University of New Mexico Project Title: Radiation Effects in III-V Nanowire Devices What are...the agency approved application or plan. The objectives of this program were to: a) develop a new nanowire transistor technology based on nanoscale

Army Enlisted Personnel Competency Assessment Program: Phase III Pilot Tests

DTIC Science & Technology

2007-03-01

Officer’s Representatives and Subject Matter POCs: Tonia Heffner and Peter Greenston Contract for Manpower, Personnel, Leader Development, and Training ...3926 March 2007 Army Project Number Personnel Performance 622785A790 and Training Technology Approved for public release; distribution is unlimited. 111...8217 ARMY ENLISTED PERSONNEL COMPETENCY ASSESSMENT PROGRAM: PHASE III PILOT TESTS EXECUTIVE SUMMARY Research Requirement: The Army Training and Leader

Options: A Career Development Curriculum for Rural High School Students. Unit III, Life Planning [and] Game of Life: Choice and Chance.

ERIC Educational Resources Information Center

Dunne, Faith; And Others

Designed to last approximately 12 days, Unit III of the 4-unit life planning and career development curriculum for rural high school students focuses on skills application. Through experience simulation, students apply skills learned in Unit II to the information from Unit I; they project their future lives and simulate their responses to problems…

Active Center Control of Termination by RNA Polymerase III and tRNA Gene Transcription Levels In Vivo

PubMed Central

Rijal, Keshab; Maraia, Richard J.

2016-01-01

The ability of RNA polymerase (RNAP) III to efficiently recycle from termination to reinitiation is critical for abundant tRNA production during cellular proliferation, development and cancer. Yet understanding of the unique termination mechanisms used by RNAP III is incomplete, as is its link to high transcription output. We used two tRNA-mediated suppression systems to screen for Rpc1 mutants with gain- and loss- of termination phenotypes in S. pombe. 122 point mutation mutants were mapped to a recently solved 3.9 Å structure of yeast RNAP III elongation complex (EC); they cluster in the active center bridge helix and trigger loop, as well as the pore and funnel, the latter of which indicate involvement of the RNA cleavage domain of the C11 subunit in termination. Purified RNAP III from a readthrough (RT) mutant exhibits increased elongation rate. The data strongly support a kinetic coupling model in which elongation rate is inversely related to termination efficiency. The mutants exhibit good correlations of terminator RT in vitro and in vivo, and surprisingly, amounts of transcription in vivo. Because assessing in vivo transcription can be confounded by various parameters, we used a tRNA reporter with a processing defect and a strong terminator. By ruling out differences in RNA decay rates, the data indicate that mutants with the RT phenotype synthesize more RNA than wild type cells, and than can be accounted for by their increased elongation rate. Finally, increased activity by the mutants appears unrelated to the RNAP III repressor, Maf1. The results show that the mobile elements of the RNAP III active center, including C11, are key determinants of termination, and that some of the mutations activate RNAP III for overall transcription. Similar mutations in spontaneous cancer suggest this as an unforeseen mechanism of RNAP III activation in disease. PMID:27518095

History of Concurrency. The Controversy of Military Acquisition Program Schedule Compression

DTIC Science & Technology

1986-09-01

33 The Manhattan Project . ........... 35 Post-War Acquisition . . . . ...... 40 The Lockheed Skunk Works ........ 42 iii Era of Controversy...been involved Vin the Manhattan Project (47:55). The concurrency concept and the innovative foundation of the Air Force Ballistic Missile Program...inter- F4 continental oallistic missile. To snorten the program’s development time they drew upon lessons from the Manhattan Project and made three

Galleria mellonella apolipophorin III - an apolipoprotein with anti-Legionella pneumophila activity.

PubMed

Zdybicka-Barabas, Agnieszka; Palusińska-Szysz, Marta; Gruszecki, Wiesław I; Mak, Paweł; Cytryńska, Małgorzata

2014-10-01

The greater wax moth Galleria mellonella has been exploited worldwide as an alternative model host for studying pathogenicity and virulence factors of different pathogens, including Legionella pneumophila, a causative agent of a severe form of pneumonia called Legionnaires' disease. An important role in the insect immune response against invading pathogens is played by apolipophorin III (apoLp-III), a lipid- and pathogen associated molecular pattern-binding protein able to inhibit growth of some Gram-negative bacteria, including Legionella dumoffii. In the present study, anti-L. pneumophila activity of G. mellonella apoLp-III and the effects of the interaction of this protein with L. pneumophila cells are demonstrated. Alterations in the bacteria cell surface occurring upon apoLp-III treatment, revealed by Fourier transform infrared (FTIR) spectroscopy and atomic force microscopy, are also documented. ApoLp-III interactions with purified L. pneumophila LPS, an essential virulence factor of the bacteria, were analysed using electrophoresis and immunoblotting with anti-apoLp-III antibodies. Moreover, FTIR spectroscopy was used to gain detailed information on the type of conformational changes in L. pneumophila LPS and G. mellonella apoLp-III induced by their mutual interactions. The results indicate that apoLp-III binding to components of bacterial cell envelope, including LPS, may be responsible for anti-L. pneumophila activity of G. mellonella apoLp-III. Copyright © 2014 Elsevier B.V. All rights reserved.

Cortical compression rapidly trimmed transcallosal projections and altered axonal anterograde transport machinery.

PubMed

Chen, Li-Jin; Wang, Yueh-Jan; Tseng, Guo-Fang

2017-10-24

Trauma and tumor compressing the brain distort underlying cortical neurons. Compressed cortical neurons remodel their dendrites instantly. The effects on axons however remain unclear. Using a rat epidural bead implantation model, we studied the effects of unilateral somatosensory cortical compression on its transcallosal projection and the reversibility of the changes following decompression. Compression reduced the density, branching profuseness and boutons of the projection axons in the contralateral homotopic cortex 1week and 1month post-compression. Projection fiber density was higher 1-month than 1-week post-compression, suggesting adaptive temporal changes. Compression reduced contralateral cortical synaptophysin, vesicular glutamate transporter 1 (VGLUT1) and postsynaptic density protein-95 (PSD95) expressions in a week and the first two marker proteins further by 1month. βIII-tubulin and kinesin light chain (KLC) expressions in the corpus callosum (CC) where transcallosal axons traveled were also decreased. Kinesin heavy chain (KHC) level in CC was temporarily increased 1week after compression. Decompression increased transcallosal axon density and branching profuseness to higher than sham while bouton density returned to sham levels. This was accompanied by restoration of synaptophysin, VGLUT1 and PSD95 expressions in the contralateral cortex of the 1-week, but not the 1-month, compression rats. Decompression restored βIII-tubulin, but not KLC and KHC expressions in CC. However, KLC and KHC expressions in the cell bodies of the layer II/III pyramidal neurons partially recovered. Our results show cerebral compression compromised cortical axonal outputs and reduced transcallosal projection. Some of these changes did not recover in long-term decompression. Copyright © 2017 IBRO. Published by Elsevier Ltd. All rights reserved.

Trivalent methylated arsenical-induced phosphatidylserine exposure and apoptosis in platelets may lead to increased thrombus formation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bae, Ok-Nam; Lim, Kyung-Min; AMOREPACIFIC CO/R and D Center, Gyeonggi-do 446-729

2009-09-01

Trivalent methylated metabolites of arsenic, monomethylarsonous acid (MMA{sup III}) and dimethylarsinous acid (DMA{sup III}), have been found highly reactive and toxic in various cells and in vivo animal models, suggesting their roles in the arsenic-associated toxicity. However, their effects on cardiovascular system including blood cells, one of the most important targets for arsenic toxicity, remain poorly understood. Here we found that MMA{sup III} and DMA{sup III} could induce procoagulant activity and apoptosis in platelets, which play key roles in the development of various cardiovascular diseases (CVDs) through excessive thrombus formation. In freshly isolated human platelets, treatment of MMA{sup III} resultedmore » in phosphatidylserine (PS) exposure, a hallmark of procoagulant activation, accompanied by distinctive apoptotic features including mitochondrial membrane potential disruption, cytochrome c release, and caspase-3 activation. These procoagulant activation and apoptotic features were found to be mediated by the depletion of protein thiol and intracellular ATP, and flippase inhibition by MMA{sup III}, while the intracellular calcium increase or reactive oxygen species generation was not involved. Importantly, increased platelet procoagulant activity by MMA{sup III} resulted in enhanced blood coagulation and excessive thrombus formation in a rat in vivo venous thrombosis model. DMA{sup III} also induced PS-exposure with apoptotic features mediated by protein thiol depletion, which resulted in enhanced thrombin generation. In summary, we believe that this study provides an important evidence for the role of trivalent methylated arsenic metabolites in arsenic-associated CVDs, giving a novel insight into the role of platelet apoptosis in toxicant-induced cardiovascular toxicity.« less

Adrenaline and triiodothyronine modify the iron handling in the freshwater air-breathing fish Anabas testudineus Bloch: role of ferric reductase in iron acquisition.

PubMed

Rejitha, V; Peter, M C Subhash

2013-01-15

The effects of in vivo adrenaline and triiodothyronine (T(3)) on ferric reductase (FR) activity, a membrane-bound enzyme that reduces Fe(III) to Fe(II) iron, were studied in the organs of climbing perch (Anabas testudineus Bloch). Adrenaline injection (10 ng g(-1)) for 30 min produced significant inhibition of FR activity in the liver and kidney and that suggests a role for this stress hormone in iron acquisition in this fish. Short-term T(3) injection (40 ng g(-1)) reduced FR activity in the gills of fed fish but not in the unfed fish. Similar reduction of FR activity was also obtained in the intestine and kidney of fed fish after T(3) injection. Feeding produced pronounced decline in FR activity in the spleen but T(3) challenge in fed and unfed fish increased its activity in this iron storing organ and that point to the sensitivity of FR system to feeding activity. The in vitro effects of Fe on FR activity in the gill explants of freshwater fish showed correlations of FR with Na(+), K(+)-ATPase and H(+)-ATPase activities. Substantial increase in the FR activity was found in the gill explants incubated with all the tested doses of Fe(II) iron (1.80, 3.59 and 7.18 μM) and Fe(III) iron (1.25, 2.51 and 5.02 μM) and this indicate that FR and Na pump activity are positively correlated. On the contrary, substantial reduction of gill H(+)-ATPase activity was found in the gill explants incubated with Fe(II) iron and Fe(III) iron indicating that perch gills may not require a high acidic microenvironment for the reduction of Fe(III) iron. Accumulation of iron in the gill explants after Fe(III) iron incubation implies a direct relationship between Fe acquisition and FR activity in this tissue. The inverse correlation between FR activity and H(+)-ATPase activity in Fe(II) or Fe(III) loaded gills and the significant positive correlations of FR activity with total [Fe] content in the Fe(III) loaded gills substantiate that FR which shows sensitivity to sodium and proton pumps, has a vital role in Fe(II) and Fe(III) iron handling in this fish. Our data also provide evidence that adrenaline, T(3) and the feeding status are the vital factors that can regulate the storage and handling of iron in fish. Copyright © 2012 Elsevier Inc. All rights reserved.

Oxidation-promoted activation of a ferrocene C-H bond by a rhodium complex.

PubMed

Labande, Agnès; Debono, Nathalie; Sournia-Saquet, Alix; Daran, Jean-Claude; Poli, Rinaldo

2013-05-14

The oxidation of a rhodium(I) complex containing a ferrocene-based heterodifunctional phosphine N-heterocyclic carbene (NHC) ligand produces a stable, planar chiral rhodium(III) complex with an unexpected C-H activation on ferrocene. The oxidation of rhodium(I) to rhodium(III) may be accomplished by initial oxidation of ferrocene to ferrocenium and subsequent electron transfer from rhodium to ferrocenium. Preliminary catalytic tests showed that the rhodium(III) complex is active for the Grignard-type arylation of 4-nitrobenzaldehyde via C-H activation of 2-phenylpyridine.

Lhires III High Resolution Spectrograph

NASA Astrophysics Data System (ADS)

Thizy, O.

2007-05-01

By spreading the light from celestial objects by wavelength, spectroscopists are like detectives looking for clues and identifying guilty phenomena that shape their spectra. We will review some basic principles in spectroscopy that will help, at our amateur level, to understand how spectra are shaped. We will review the Lhires III highresolution spectrograph Mark Three that was designed to reveal line profile details and subtle changes. Then, we will do an overview of educational and scientific projects that are conducted with the Lhires III and detail the COROT Be star program and the BeSS database for which the spectrograph is a key instrument.

Subsurface Characterization and Seismic Monitoring for the Southwest Partnerships Phase III Demonstration Project at Farnsworth Field, TX

NASA Astrophysics Data System (ADS)

Will, R. A.; Balch, R. S.

2015-12-01

The Southwest Partnership on Carbon Sequestration is performing seismic based characterization and monitoring activities at an active CO2 EOR project at Farnsworth Field, Texas. CO2 is anthropogenically sourced from a fertilizer and an ethanol plant. The field has 13 CO2 injectors and has sequestered 302,982 metric tonnes of CO2 since October 2013. The field site provides an excellent laboratory for testing a range of monitoring technologies in an operating CO2 flood since planned development is sequential and allows for multiple opportunities to record zero CO2 baseline data, mid-flood data, and fully flooded data. The project is comparing and contrasting several scales of seismic technologies in order to determine best practices for large scale commercial sequestration projects. Characterization efforts include an 85 km2 3D surface seismic survey, baseline and repeat 3D VSP surveys centered on injection wells, cross-well tomography baseline and repeat surveys between injector/producer pairs, and a borehole passive seismic array to monitor induced seismicity. All surveys have contributed to detailed geologic models which were then used for fluid flow and risk assessment simulations. 3D VSP and cross-well data with repeat surveys have allowed for direct comparisons of the reservoir prior to CO2 injection and at eight months into injection, with a goal of imaging the CO2 plume as it moves away from injection wells. Additional repeat surveys at regular intervals will continue to refine the plume. The goal of this work is to demonstrate seismic based technologies to monitor CO2 sequestration projects, and to contribute to best practices manuals for commercial scale CO2 sequestration projects. In this talk the seismic plan will be outlined, progress towards goals enumerated, and preliminary results from baseline and repeat seismic data will be discussed. Funding for this project is provided by the U.S. Department of Energy under Award No. DE-FC26-05NT42591.

[Effects of iron on azoreduction by Shewanella decolorationis S12].

PubMed

Chen, Xing-Juan; Xu, Mei-Ying; Sun, Guo-Ping

2010-01-01

The effects of soluble and insoluble Fe(III) on anaerobic azoreduction by Shewanella decolorationis S12 were examined in a series of experiments. Results showed that the effects of iron on anaerobic azoreduction depended on the solubility and concentration of the compounds. Azoreduction was inhibited by insoluble Fe(III) and 0.05-2 mmol/L Fe2 O3 all decelerated the azoreduction activity of 0.2 mmol/L amaranth, but the increase in the concentrations of Fe2O3 did not cause an increasing inhibition. Soluble Fe(III) of which concentration less than 0.4 mmol/L enhanced azoreduction activity of 0.2 mmol/L amaranth but there was no linear relationship between the concentration of soluble Fe(III) and azoreduction activity. Soluble Fe(III) of which concentration more than 1 mmol/L inhibited azoreduction activity of 0.2 mmol/L amaranth and an increasing concentration resulted in an increased inhibition. The inhibition was strengthened under the conditions of limited electron donor. On the other hand, soluble Fe(III) and Fe(II) could relieve the inhibition of azoreduction by dicumarol which blocked quinone cycle. It suggests that in addition to quinone cycle, there is a Fe(III) <--> Fe(II) cycle shuttling electrons in cytoplasmic and periplasmic environment. That is the reason why low concentration of soluble Fe(III) or Fe (II) can enhance azoreduction of S. decolorationis S12. It also indicates that insoluble Fe(III) and high concentration of soluble Fe(III) do compete with azo dye for electrons once it acts as electron acceptor. Thus, when iron and azo dye coexisted, iron could serve as an electron transfer agent or electron competitive inhibitor for anaerobic azoreduction under different conditions. High efficiency of azoreduction can be achieved through controlling the solubility and concentration of irons.

Characterization of a heterobimetallic nonheme Fe(III)-O-Cr(III) species formed by O2 activation.

PubMed

Zhou, Ang; Kleespies, Scott T; Van Heuvelen, Katherine M; Que, Lawrence

2015-10-01

We report the generation and spectroscopic characterization of a heterobimetallic [(TMC)Fe(III)-O-Cr(III)(OTf)4] species (1) by bubbling O2 into a mixture of Fe(TMC)(OTf)2 and Cr(OTf)2 in NCCH3. Complex 1 also formed quantitatively by adding Cr(OTf)2 to [Fe(IV)(O)(TMC)(NCCH3)](2+). The proposed O2 activation mechanism involves the trapping of a Cr-O2 adduct by Fe(TMC)(OTf)2.

Characterization of a Heterobimetallic Nonheme Fe(III)-O-Cr(III) Species Formed by O2 Activation

PubMed Central

Zhou, Ang; Kleespies, Scott T.; Van Heuvelen, Katherine M.; Que, Lawrence

2015-01-01

We report the generation and spectroscopic characterization of a heterobimetallic [(TMC)FeIII-O-CrIII(OTf)4] species (1) by O2 bubbling into a mixture of Fe(TMC)(OTf)2 and Cr(OTf)2 in NCCH3. Complex 1 also formed quantitatively by adding Cr(OTf)2 to [FeIV(O)(TMC)(NCCH3)]2+. The proposed O2 activation mechanism involves the trapping by a Cr-O2 adduct by Fe(TMC)(OTf)2. PMID:26265081

Domestic Abuse Prevention Education: Listening to the Views of Young People

ERIC Educational Resources Information Center

Fox, Claire L.; Hale, Rebecca; Gadd, David

2014-01-01

This paper reports on findings derived as part of a two-year project funded by the European Union's Daphne III scheme, involving collaboration between seven partner organisations across six European countries. The project involved an evaluation, using questionnaires and focus groups, of domestic abuse prevention education programmes delivered in…

Vocational Training and Placement of Severely Disabled Persons. Project Employability--Volume III.

ERIC Educational Resources Information Center

Wehman, Paul, Ed.; Hill, Mark, Ed.

The document contains nine papers reporting the effectiveness of Project Employability, a program to demonstrate and evaluate a training model providing job site training, advocacy, and long term followup for severely disabled individuals. In "Job Placement and Follow-Up of Moderately and Severely Handicapped Individuals--An Update After…

76 FR 73691 - Notice of Entering Into a Compact With the Republic of Indonesia

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-29

... projects funded by the GP Facility are designed on the basis of accurate spatial and land use data, and... plans, project identification and design, preparation of business plans and funding applications, and...) achievement of agreed legal and policy changes; (iii) agreement regarding the final design of phase two; and...

Mentoring Women in the Frederick Community | Poster

Cancer.gov

Joy Beveridge, clinical project manager III, is all about building relationships. Her work as a clinical project manager requires her to manage teams such as the Coordinating Center for Clinical Trials, Center for Global Health, Brain Tumor Trials Collaborative, and Division of Cancer Treatment and Diagnosis. Equally important are the relationships Beveridge builds through her

College and Industry: Partners in the Handicapped Role (Cipher III).

ERIC Educational Resources Information Center

Katz, David; And Others

A project was designed and instituted to furnish a structure that would bring together three groups--potential employers, college personnel, and disabled people--to increase employment opportunities for the handicapped. During the third and final project year, representatives of all three groups met in workshops to discuss issues and concerns.…

Title III: Curricular Development for Secondary Learning Disabilities. Final Report.

ERIC Educational Resources Information Center

Goodman, Libby

Presented is the final report of a 2-year project to develop an examplary model classroom program and curriculum for the secondary learning disabled student. Section I consists of completed forms entitled Project Completion Report, Termination Report, and Equipment Inventory. Outlined in Section II is information on the following project…

Manual for Developing a Senior Citizen Teacher Aide Program.

ERIC Educational Resources Information Center

Oregon State Dept. of Education, Salem.

The Senior Aide Volunteer Educator (SAVE) project in Tigard School District 23J, Tigard, Oregon, was initiated in 1971 under ESEA Title III funding to provide additional instruction to selected students from the first six grades in the areas of reading, mathematics, and elementary science. Examples from this project are often cited, but this…

Project Success Environment: A Positive Contingency Program for Elementary Teachers Management.

ERIC Educational Resources Information Center

Thompson, Marion; And Others

The third year of the project, funded under Elementary Secondary Education Act Title III, was essentially a replication of Year Two. Second Year results indicated that the success technique had provided inner-city teachers with both an effective classroom management system, and an effective program for the acceleration of academic performance.…

26 CFR 1.1039-1 - Certain sales of low-income housing projects.

Code of Federal Regulations, 2013 CFR

2013-04-01

... condition of sale, or is required by the Secretary of Housing and Urban Development or his delegate as a condition of approval of the disposition. (iii) Examples of taxes that are attributable to the approved... and bears the burdens and enjoys the benefits of ownership of the replacement project. (For special...

North Dakota Statewide Nursing Study, Phase III. Final Report and Recommendations.

ERIC Educational Resources Information Center

Clark, Neil; Smith, David

The process, outcomes, and recommendations resulting from a project to develop a statewide nursing resource planning system are examined. Phase 1 of the project investigated nursing manpower demands for 1984 and 1986, while phase 2 studied the current scope of nursing practice. In addition to summarizing the findings of these investigations,…

Restoration as Responsibility: An Interview with Bill Jordan III.

ERIC Educational Resources Information Center

Jordan, Bill, III

2002-01-01

Interest in ecological restoration is increasing. A pioneer in the field discusses the value of restoration projects; deciding what state of the landscape to restore; how to educate people about the importance of reintroducing species, especially large predators; why people are so willing to volunteer and sacrifice for restoration projects; and…

7 CFR 1703.311 - Application procedures for deferment of loan payments.

Code of Federal Regulations, 2010 CFR

2010-01-01

... specific project; (iii) Contain information on the type of project and the length of deferment requested as... and disclose all information regarding any potential conflict of interest or appearance of a conflict... applicable, the number and type of jobs to be created; and (9) Submit to the Administrator a letter of...

15 CFR Appendix B to Subpart R of... - Minor Projects for Purposes of § 922.193(a)(2)(iii)

Code of Federal Regulations, 2010 CFR

2010-01-01

...), the Michigan Department of Environmental Quality (Department) issues permits for projects that are of... values or interests, including navigation and water quality. (h) Fish or wildlife habitat structures..., water monitoring devices, water quality testing devices, survey devices, and core sampling devices, if...

75 FR 78234 - Lock+TM

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-15

... project (Project No. 13780-000) would consist of: (1) An 85-foot-long, 100-foot-wide, 14-foot-deep excavated power canal; (2) a 95-foot-long, 100-foot-wide, 10-foot-deep excavated tailrace; (3) a 100-foot...)(iii) and the instructions on the Commission's Web site http://www.ferc.gov/docs-filing/efiling.asp...

Reaction-Based Reactive Transport Modeling of Iron Reduction and Uranium Immobilization at Area 2 of the NABIR Field Research Center

DOE Office of Scientific and Technical Information (OSTI.GOV)

Burgos, W.D.

2009-09-02

This report summarizes research conducted in conjunction with a project entitled “Reaction-Based Reactive Transport Modeling of Iron Reduction and Uranium Immobilization at Area 2 of the NABIR Field Research Center”, which was funded through the Integrative Studies Element of the former NABIR Program (now the Environmental Remediation Sciences Program) within the Office of Biological and Environmental Research. Dr. William Burgos (The Pennsylvania State University) was the overall PI/PD for the project, which included Brian Dempsey (Penn State), Gour-Tsyh (George) Yeh (Central Florida University), and Eric Roden (formerly at The University of Alabama, now at the University of Wisconsin) as separately-fundedmore » co-PIs. The project focused on development of a mechanistic understanding and quantitative models of coupled Fe(III)/U(VI) reduction in FRC Area 2 sediments. The work builds on our previous studies of microbial Fe(III) and U(VI) reduction, and was directly aligned with the Scheibe et al. ORNL FRC Field Project at Area 2.« less

Tiger LDRD final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Steich, D J; Brugger, S T; Kallman, J S

2000-02-01

This final report describes our efforts on the Three-Dimensional Massively Parallel CEM Technologies LDRD project (97-ERD-009). Significant need exists for more advanced time domain computational electromagnetics modeling. Bookkeeping details and modifying inflexible software constitute a vast majority of the effort required to address such needs. The required effort escalates rapidly as problem complexity increases. For example, hybrid meshes requiring hybrid numerics on massively parallel platforms (MPPs). This project attempts to alleviate the above limitations by investigating flexible abstractions for these numerical algorithms on MPPs using object-oriented methods, providing a programming environment insulating physics from bookkeeping. The three major design iterationsmore » during the project, known as TIGER-I to TIGER-III, are discussed. Each version of TIGER is briefly discussed along with lessons learned during the development and implementation. An Application Programming Interface (API) of the object-oriented interface for Tiger-III is included in three appendices. The three appendices contain the Utilities, Entity-Attribute, and Mesh libraries developed during the project. The API libraries represent a snapshot of our latest attempt at insulated the physics from the bookkeeping.« less

Project 8, Phase III Design: Placing an eV-Scale Limit on the Neutrino Mass using Cyclotron Radiation Emission Spectroscopy

NASA Astrophysics Data System (ADS)

Oblath, Noah; Project 8 Collaboration

2016-09-01

We report on the design concept for Phase III of the Project 8 experiment. In the third phase of Project 8 we aim to place a limit on the neutrino mass that is similar to the current limits set by tritium beta-decay experiments, mν < 2eV . From the first two phases of Project 8 we move to a novel design consisting of a 100cm3 cylindrical volume of tritium gas instrumented with two 30-element rings of inward-facing antennas. Beam-forming techniques similar to those used in radioastronomy will be employed to search for and track electron signals in the fiducial volume. This talk will present the quantitative design concept for the phased-array receiver, and illustrate how we are progressing towards the Phase IV experiment, which will have sensitivity to the neutrino mass scale allowed by the inverted mass hierarchy. This work is supported by the DOE Office of Science Early Career Research Program, and the Laboratory Directed Research and Development Program at Pacific Northwest National Laboratory.

Distinct mechanisms underlie activation of hypothalamic neurosecretory neurons and their medullary catecholaminergic afferents in categorically different stress paradigms.

PubMed Central

Li, H Y; Ericsson, A; Sawchenko, P E

1996-01-01

Intermittent electrical footshock induces c-fos expression in parvocellular neurosecretory neurons expressing corticotropin-releasing factor and in other visceromotor cell types of the paraventricular hypothalamic nucleus (PVH). Since catecholaminergic neurons of the nucleus of the solitary tract and ventrolateral medulla make up the dominant loci of footshock-responsive cells that project to the PVH, these were evaluated as candidate afferent mediators of hypothalamic neuroendocrine responses. Rats bearing discrete unilateral transections of this projection system were exposed to a single 30-min footshock session and sacrificed 2 hr later. Despite depletion of the aminergic innervation on the ipsilateral side, shock-induced up-regulation of Fos protein and corticotropin-releasing factor mRNA were comparable in strength and distribution in the PVH on both sides of the brain. This lesion did, however, result in a substantial reduction of Fos expression in medullary aminergic neurons on the ipsilateral side. These results contrast diametrically with those obtained in a systemic cytokine (interleukin 1) challenge paradigm, where similar cuts ablated the Fos response in the ipsilateral PVH but left intact the induction seen in the ipsilateral medulla. We conclude that (i) footshock-induced activation of medullary aminergic neurons is a secondary consequence of stress, mediated via a descending projection transected by our ablation, (ii) stress-induced activation of medullary aminergic neurons is not necessarily predictive of an involvement of these cell groups in driving hypothalamic visceromotor responses to a given stressor, and (iii) despite striking similarities in the complement of hypothalamic effector neurons and their afferents that may be activated by stresses of different types, distinct mechanisms may underlie adaptive hypothalamic responses in each. Images Fig. 1 Fig. 3 Fig. 4 Fig. 5 PMID:8637878

Distinguishing Core and Holoenzyme Mechanisms of Transcription Termination by RNA Polymerase III

PubMed Central

Arimbasseri, Aneeshkumar G.

2013-01-01

Transcription termination by RNA polymerase (Pol) III serves multiple purposes; it delimits interference with downstream genes, forms 3′ oligo(U) binding sites for the posttranscriptional processing factor, La protein, and resets the polymerase complex for reinitiation. Although an interplay of several Pol III subunits is known to collectively control these activities, how they affect molecular function of the active center during termination is incompletely understood. We have approached this using immobilized Pol III-nucleic acid scaffolds to examine the two major components of termination, transcription pausing and RNA release. This allowed us to distinguish two mechanisms of termination by isolated Saccharomyces cerevisiae Pol III. A core mechanism can operate in the absence of C53/37 and C11 subunits but requires synthesis of 8 or more 3′ U nucleotides, apparently reflecting inherent sensitivity to an oligo(rU·dA) hybrid that is the termination signal proper. The holoenzyme mechanism requires fewer U nucleotides but uses C53/37 and C11 to slow elongation and prevent terminator arrest. N-terminal truncation of C53 or point mutations that disable the cleavage activity of C11 impair their antiarrest activities. The data are consistent with a model in which C53, C37, and C11 activities are functionally integrated with the active center of Pol III during termination. PMID:23401852

JS-III-49, a hydroquinone derivative, exerts anti-inflammatory activity by targeting Akt and p38

PubMed Central

Yi, Young-Su

2017-01-01

Since previous studies have reported that hydroquinone (HQ) exerted immunosuppressive and anti-inflammatory activity, various HQ derivatives have been synthesized and their biological activities investigated. In this study, we explored the anti-inflammatory activity of JS-III-49, a novel HQ derivative, in macrophage-mediated inflammatory responses. JS-III-49 suppressed the production of the inflammatory mediators nitric oxide (NO) and prostaglandin E2 (PGE2) and down-regulated the mRNA expression of the inflammatory enzymes cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) as well as the expression of the pro-inflammatory cytokines interleukin-6 (IL-6) and IL-1b without cytotoxicity in LPS-stimulated RAW264.7 cells. JS-III-49 inhibited nuclear translocation of the NF-kB transcription factors p65 and p50 by directly targeting Akt, an upstream kinase of the NF-kB pathway, in LPS-stimulated RAW264.7 cells. However, JS-III-49 did not directly inhibit the kinase activities of Src and Syk, which are upstream kinases of Akt, in LPS-stimulated RAW264.7 cells. Moreover, JS-III-49 suppressed the nuclear translocation of c-Fos, one of the components of AP-1, by specifically targeting p38, an upstream mitogen-activated protein kinase (MAPK) in the AP-1 pathway in LPS-stimulated RAW264.7 cells. These results suggest that JS-III-49 plays an anti-inflammatory role in LPS-stimulated macrophages by targeting Akt and p38 in the NF-kB and AP-1 pathways, respectively. PMID:28461777

JS-III-49, a hydroquinone derivative, exerts anti-inflammatory activity by targeting Akt and p38.

PubMed

Yi, Young-Su; Kim, Mi-Yeon; Cho, Jae Youl

2017-05-01

Since previous studies have reported that hydroquinone (HQ) exerted immunosuppressive and anti-inflammatory activity, various HQ derivatives have been synthesized and their biological activities investigated. In this study, we explored the anti-inflammatory activity of JS-III-49, a novel HQ derivative, in macrophage-mediated inflammatory responses. JS-III-49 suppressed the production of the inflammatory mediators nitric oxide (NO) and prostaglandin E 2 (PGE 2 ) and down-regulated the mRNA expression of the inflammatory enzymes cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) as well as the expression of the pro-inflammatory cytokines interleukin-6 (IL-6) and IL-1b without cytotoxicity in LPS-stimulated RAW264.7 cells. JS-III-49 inhibited nuclear translocation of the NF-kB transcription factors p65 and p50 by directly targeting Akt, an upstream kinase of the NF-kB pathway, in LPS-stimulated RAW264.7 cells. However, JS-III-49 did not directly inhibit the kinase activities of Src and Syk, which are upstream kinases of Akt, in LPS-stimulated RAW264.7 cells. Moreover, JS-III-49 suppressed the nuclear translocation of c-Fos, one of the components of AP-1, by specifically targeting p38, an upstream mitogen-activated protein kinase (MAPK) in the AP-1 pathway in LPS-stimulated RAW264.7 cells. These results suggest that JS-III-49 plays an anti-inflammatory role in LPS-stimulated macrophages by targeting Akt and p38 in the NF-kB and AP-1 pathways, respectively.

Studies for Io's extended atmosphere and neutral clouds and their impact on the local satellite atmosphere and on the planetary magnetosphere

NASA Technical Reports Server (NTRS)

Smyth, William H.

1993-01-01

The research performed in this project is divided in two main investigations: (1) the synthesis and analysis of a collection of independent observations for Io's sodium corona, its sodium extended atmosphere, and the sodium cloud, and (2) the analysis of a (System III longitude correlated) space-time 'bite-out' near western elongation in the 1981 sodium cloud images from the JPL Table Mountain Sodium Cloud Data Set. For the first investigation, modeling analysis of the collective observed spatial profiles has shown that they are reproduced by adopting at Io's exobase a modified sputtering flux speed distribution function which is peaked near 0.5 km/s and has a small high-speed (15-20 km/s) nonisotropic component. The nonisotropic high-speed component is consistent with earlier modeling of the trailing directional feature. For the second investigation, modeling analysis of the 'bite-out' observed near western elongation (but not eastern elongation) has shown that it is reproduced in model calculation by adopting a plasma torus description for the sodium lifetime that is inherently asymmetric in System III longitudes of the active sector and that also has an east-west asymmetry. The east-west and System III longitude asymmetries were determined from independent observations for the plasma torus in 1981. The presence of the 'bite-out' feature only near western elongation may be understood in terms of the relative value for sodium of its lifetime and its transport time through the System III enhanced plasma torus region.

Electrosorption of As(III) in aqueous solutions with activated carbon as the electrode

NASA Astrophysics Data System (ADS)

Dai, Min; Xia, Ling; Song, Shaoxian; Peng, Changsheng; Rangel-Mendez, Jose Rene; Cruz-Gaona, Roel

2018-03-01

The electrosorption of As(III) in aqueous solutions by using activated carbon (AC) as the electrode was studied in this work. This study was performed through the measurements of adsorption and desorption, Cyclic Voltammetry (CV), Electrochemical Impedance Spectroscopy (EIS) and X-ray photoelectron spectra (XPS). Three parameters, applied voltage, solution pH and initial As(III) concentration, on the electrosoprtion of As(III) were investigated. The experimental results have demonstrated that the electrosorption followed three steps: migration of As(III) to the anode, oxidation of As(III) to As(V) and accumulation of As(V) in the electric double layers of the anode. The electrodorption capacity increased with increasing applied voltage and initial As(III) concentration, whereas the effect of pH was complicated for the variation of arsenite species and the competition of OH-. The oxidation of As(III) increased with the increasing voltage and pH due to the increasing redox potential acted on As(III). The electrosorption served to reduce the toxicity of arsenic and was a promising technology for As(III) removal from water.

Functional interaction between Cerebratulus lacteus cytolysin A-III and phospholipase A/sub 2/

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, J.; Blumenthal, K.M.

A study on the interaction between bee venom phospholipase A/sub 2/ and Cerebratulus lacteus cytolysin A-III, a major hemolysin secreted by this organism has been carried out. The hemolytic activity of A-III in phosphate-buffered saline is increased 5-fold in the presence of phospholipase A/sub 2/ from bee venom. Dansylphosphatidylethanolamine (DPE) labeled, phosphatidylcholine-containing liposomes and human erythrocyte membranes were employed to study the interaction between these two proteins. In DPE-liposomes, A-III alone had no effect on DPE fluorescence nor did it enhance either the phospholipase A/sub 2/-dependent fluorescence increase or blue shift in emission maximum, indicating that the cytolysis is notmore » a major phospholipase A/sub 2/-activator. However, when DPE was incorporated into erythrocyte membranes, A-III alone induced a 40% fluorescence increase and a 5 nm blue shift, implying a transient activation of an endogenous phospholipase A/sub 2/. Further studies using synthetic lysophosphatidylcholine and free fatty acids demonstrated that the hemolytic activity of A-III is potentiated by free fatty acids, a product of phospholipid degradation catalyzed by phospholipase A/sub 2/. Subsequent analysis of this phenomenon by gel filtration chromatography, analytical ultracentrifugation, chemical cross-linking, and measurement of (/sup 14/C)oleic acid binding by the cytolysin demonstrated that binding of oleic acid to A-III causes aggregation of the toxin molecules to a tetrameric form which has a higher ..cap alpha..-helix content and a greater activity than the monomer.« less

Generation of Recombinant Human AChE OP-Scavengers with Extended Circulatory Longevity

DTIC Science & Technology

2006-11-01

PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Avigdor Shafferman Ph.D. 5d. PROJECT NUMBER 5e. TASK NUMBER E-Mail: avigdor...glycans of rHuAChE, and in particular the distal termini of these glycan 8 projections , constitute a major factor in determining the circulatory...experiments funded by sources other than the USAMRMC contract, since they may have a major impact on the present project . Section III focuses on the

Vehicle Mobility Assessment for Project Wheels Study Group

DTIC Science & Technology

1972-07-01

cash savings p’Asible through the elimination of special military automotive features, such as front-wheel 1 Idrive , or the use of commercial vehicles...E12. (12) off-,,,d mobiliY profile 4x4 0ruck, c 2Z4< 20 ,ernn It Iot "- III IIIII III I I I IIII A%. West Germany 0A * s ps ArizonazD • Ř’.. • D

Stimulation of Pol III-dependent 5S rRNA and U6 snRNA gene expression by AP-1 transcription factors.

PubMed

Ahuja, Richa; Kumar, Vijay

2017-07-01

RNA polymerase III transcribes structurally diverse group of essential noncoding RNAs including 5S ribosomal RNA (5SrRNA) and U6 snRNA. These noncoding RNAs are involved in RNA processing and ribosome biogenesis, thus, coupling Pol III activity to the rate of protein synthesis, cell growth, and proliferation. Even though a few Pol II-associated transcription factors have been reported to participate in Pol III-dependent transcription, its activation by activator protein 1 (AP-1) factors, c-Fos and c-Jun, has remained unexplored. Here, we show that c-Fos and c-Jun bind to specific sites in the regulatory regions of 5S rRNA (type I) and U6 snRNA (type III) gene promoters and stimulate their transcription. Our chromatin immunoprecipitation studies suggested that endogenous AP-1 factors bind to their cognate promoter elements during the G1/S transition of cell cycle apparently synchronous with Pol III transcriptional activity. Furthermore, the interaction of c-Jun with histone acetyltransferase p300 promoted the recruitment of p300/CBP complex on the promoters and facilitated the occupancy of Pol III transcriptional machinery via histone acetylation and chromatin remodeling. The findings of our study, together, suggest that AP-1 factors are novel regulators of Pol III-driven 5S rRNA and U6 snRNA expression with a potential role in cell proliferation. © 2017 Federation of European Biochemical Societies.

The impact of feedback from galaxy formation on the Lyman α transmitted flux

NASA Astrophysics Data System (ADS)

Viel, Matteo; Schaye, Joop; Booth, C. M.

2013-02-01

The forest of Lyman α absorption lines seen in the spectra of distant quasars has become an important probe of the distribution of matter in the Universe. We use large, hydrodynamical simulations from the OverWhelmingly Large Simulations project project to investigate the effect of feedback from galaxy formation on the probability distribution function and the power spectrum of the Lyman α transmitted flux. While metal-line cooling is unimportant, both galactic outflows from massive galaxies driven by active galactic nuclei and winds from low-mass galaxies driven by supernovae have a substantial impact on the flux statistics. At redshift z = 2.25, the effects on the flux statistics are of a similar magnitude as the statistical uncertainties of published data sets. The changes in the flux statistics are not due to differences in the temperature-density relation of the photoionized gas. Instead, they are caused by changes in the density distribution and in the fraction of hot, collisionally ionized gas. It may be possible to disentangle astrophysical and cosmological effects by taking advantage of the fact that they induce different redshift dependencies. In particular, the magnitude of the feedback effects appears to decrease rapidly with increasing redshift. Analyses of Lyman α forest data from surveys that are currently in process, such as Baryon Oscillation Spectroscopic Survey of the Sloan Digital Sky Survey-III (BOSS/SDSS-III) and X-Shooter/Very Large Telescope (VLT), must take galactic winds into account.

Expanding Earth and Space Science through the Initiating New Science Partnerships In Rural Education (INSPIRE)

NASA Astrophysics Data System (ADS)

Radencic, S.; McNeal, K. S.; Pierce, D.; Hare, D.

2010-12-01

The INSPIRE program at Mississippi State University (MSU), funded by the NSF Graduate STEM Fellows in K-12 Education (GK12) program, focuses on Earth and Space science education and has partnered ten graduate students from MSU with five teachers from local, rural school districts. For the next five years the project will serve to increase inquiry and technology experiences in science and math while enhancing graduate student’s communication skills. Graduate students, from the disciplines of Geosciences, Physics, and Engineering are partnered with Chemistry, Physical Science, Physics, Geometry and Middle school science classrooms and will create engaging inquiry activities that incorporate elements of their research, and integrate various forms of technology. The generated lesson plans that are implemented in the classroom are published on the INSPIRE home page (www.gk12.msstate.edu) so that other classroom instructors can utilize this free resource. Local 7th -12th grade students will attend GIS day later this fall at MSU to increase their understanding and interest in Earth and Space sciences. Selected graduate students and teachers will visit one of four international university partners located in Poland, Australia, England, or The Bahamas to engage research abroad. Upon return they will incorporate their global experiences into their local classrooms. Planning for the project included many factors important to the success of the partnerships. The need for the program was evident in Mississippi K-12 schools based on low performance on high stakes assessments and lack of curriculum in the Earth and Space sciences. Meeting with administrators to determine what needs they would like addressed by the project and recognizing the individual differences among the schools were integral components to tailoring project goals and to meet the unique needs of each school partner. Time for training and team building of INSPIRE teachers and graduate students before the school year aided in fostering a community atmosphere to ensure successful classroom experiences. Including stakeholders in the progress of lesson plan product development during a workshop luncheon was another key part to building a community of support for INSPIRE. These planning components are essential to the success of the project and are recommended to similar projects. The INSPIRE project external evaluation includes: (i) interviews of participants and K-12 students involved in INSPIRE, (ii) pre-post technology and teaching attitude surveys of graduate students and teachers, (iii) thematic analysis of daily feedback forms from the workshop, (iv) summary of end of workshop evaluations, and (v) constant surveying of program progress towards meeting its goals. Internal evaluation includes: (i) classroom observations of graduate student interactions with students (ii) bi-weekly journal entries from both teachers and graduate students, and (iii) weekly feedback from graduate students. Preliminary evaluation of the workshop daily feedback forms indicate a high level of approval for the technology and inquiry activities modeled. Journal entries indicate that the majority of Fellow-teacher teams experience positive interactions in the classroom.

Preparation of progenin III from total steroidal saponins of Dioscorea nipponica Makino using a crude enzyme from Aspergillus oryzae strain.

PubMed

Liu, Tingqiang; Yu, Hongshan; Liu, Chunying; Bao, Yongming; Hu, Xiangchun; Wang, Yuanhao; Liu, Bing; Fu, Yaoyao; Tang, Sihui; Jin, Fengxie

2013-05-01

Progenin III, one of the most active spirostanol saponins, is a potential candidate for anti-cancer therapy due to its strong antitumor activity and low hemolytic activity. However, the concentration of progenin III is extremely low in natural Dioscorea plants. In this paper, the progenin III production from total steroidal saponins of Dioscorea nipponica Makino was studied using the crude enzyme from Aspergillus oryzae DLFCC-38. The crude enzyme converting total steroidal saponins into progenin III was obtained from the A. oryzae DLFCC-38 culture. For enzyme production, the strain was cultured for 72 h at 30 °C with shaking at 150 rpm in 5 % (w/v) malt extract medium containing 2 % (v/v) extract of D. nipponica as the enzyme inducer. The crude enzyme converted total steroidal saponins into major progenin III with a high yield when the reaction was carried out for 9 h at 50 °C and pH 5.0 with the 20 mg/ml of substrate. In the preparation of progenin III, 117 g of crude progenin III was obtained from 160 g of substrate, and the crude product was purified with silica gel column to obtain 60.3 g progenin III of 93.4 % purity.

Molecular structure and biological studies on Cr(III), Mn(II) and Fe(III) complexes of heterocyclic carbohydrazone ligand.

PubMed

Abu El-Reash, G M; El-Gammal, O A; Radwan, A H

2014-01-01

The chelating behavior of the ligand (H2APC) based on carbohydrazone core modified with pyridine end towards Cr(III), Mn(II) and Fe(III) ions have been examined. The (1)H NMR and IR data for H2APC revealed the presence of two stereoisomers syn and anti in both solid state and in solution in addition to the tautomeric versatility based on the flexible nature of the hydrazone linkage leading to varied coordination modes. The spectroscopic data confirmed that the ligand behaves as a monobasic tridentate in Cr(III) and Fe(III) complexes and as neutral tetradentate in Mn(II) complex. The electronic spectra as well as the magnetic measurements confirmed the octahedral geometry for all complexes. The bond length and angles were evaluated by DFT method using material studio program for all complexes. The thermal behavior and the kinetic parameters of degradation were determined using Coats-Redfern and Horowitz-Metzger methods. The antioxidant (DDPH and ABTS methods), anti-hemolytic and cytotoxic activities of the compounds have been screened. Cr(III) complex and H2APC showed the highest antioxidant activity using ABTS and DPPH methods. With respect to in vitro Ehrlich ascites assay, H2APC exhibited the potent activity followed by Fe(III) and Cr(III)complexes. Copyright © 2013 Elsevier B.V. All rights reserved.

Structural Basis of Vta1 Function in the Multivesicular Body Sorting Pathway

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xiao, Junyu; Xia, Hengchuan; Zhou, Jiahai

The MVB pathway plays essential roles in several eukaryotic cellular processes. Proper function of the MVB pathway requires reversible membrane association of the ESCRTs, a process catalyzed by Vps4 ATPase. Vta1 regulates the Vps4 activity, but its mechanism of action was poorly understood. We report the high-resolution crystal structures of the Did2- and Vps60-binding N-terminal domain and the Vps4-binding C-terminal domain of S. cerevisiae Vta1. The C-terminal domain also mediates Vta1 dimerization and both subunits are required for its function as a Vps4 regulator. Emerging from our analysis is a mechanism of regulation by Vta1 in which the C-terminal domainmore » stabilizes the ATP-dependent double ring assembly of Vps4. In addition, the MIT motif-containing N-terminal domain, projected by a long disordered linker, allows contact between the Vps4 disassembly machinery and the accessory ESCRT-III proteins. This provides an additional level of regulation and coordination for ESCRT-III assembly and disassembly.« less

Type III secretion system effector proteins: double agents in bacterial disease and plant defense.

PubMed

Alfano, James R; Collmer, Alan

2004-01-01

Many phytopathogenic bacteria inject virulence effector proteins into plant cells via a Hrp type III secretion system (TTSS). Without the TTSS, these pathogens cannot defeat basal defenses, grow in plants, produce disease lesions in hosts, or elicit the hypersensitive response (HR) in nonhosts. Pathogen genome projects employing bioinformatic methods to identify TTSS Hrp regulon promoters and TTSS pathway targeting signals suggest that phytopathogenic Pseudomonas, Xanthomonas, and Ralstonia spp. harbor large arsenals of effectors. The Hrp TTSS employs customized cytoplasmic chaperones, conserved export components in the bacterial envelope (also used by the TTSS of animal pathogens), and a more specialized set of TTSS-secreted proteins to deliver effectors across the plant cell wall and plasma membrane. Many effectors can act as molecular double agents that betray the pathogen to plant defenses in some interactions and suppress host defenses in others. Investigations of the functions of effectors within plant cells have demonstrated the plasma membrane and nucleus as subcellular sites for several effectors, revealed some effectors to possess cysteine protease or protein tyrosine phosphatase activity, and provided new clues to the coevolution of bacterium-plant interactions.

Structural basis of Vta1 function in the multi-vesicular body sorting pathway

PubMed Central

Xiao, Junyu; Xia, Hengchuan; Zhou, Jiahai; Azmi, Ishara; Davies, Brian A.; Katzmann, David J.; Xu, Zhaohui

2009-01-01

Summary The MVB pathway plays essential roles in several eukaryotic cellular processes. Proper function of the MVB pathway requires reversible membrane association of the ESCRTs, a process catalyzed by Vps4 ATPase. Vta1 regulates the Vps4 activity but its mechanism of action was poorly understood. We report the high-resolution crystal structures of the Did2- and Vps60-binding N-terminal domain and the Vps4-binding C-terminal domain of S. cerevisiae Vta1. The C-terminal domain also mediates Vta1 dimerization and both subunits are required for its function as a Vps4 regulator. Emerging from our analysis is a mechanism of regulation by Vta1 in which the C-terminal domain stabilizes the ATP-dependent double ring assembly of Vps4. In addition, the MIT motif containing N-terminal domain, projected by a long disordered linker, allows contact between the Vps4 disassembly machinery and the accessory ESCRT-III proteins. This provides an additional level of regulation and coordination for ESCRT-III assembly and disassembly. PMID:18194651

Structure and reactivity of a mononuclear non-haem iron(III)–peroxo complex

PubMed Central

Cho, Jaeheung; Jeon, Sujin; Wilson, Samuel A.; Liu, Lei V.; Kang, Eun A; Braymer, Joseph J.; Lim, Mi Hee; Hedman, Britt; Hodgson, Keith O.; Valentine, Joan Selverstone; Solomon, Edward I.; Nam, Wonwoo

2012-01-01

Oxygen-containing mononuclear iron species—iron(III)–peroxo, iron(III)–hydroperoxo and iron(IV)–oxo—are key intermediates in the catalytic activation of dioxygen by iron-containing metalloenzymes1–7. It has been difficult to generate synthetic analogues of these three active iron–oxygen species in identical host complexes, which is necessary to elucidate changes to the structure of the iron centre during catalysis and the factors that control their chemical reactivities with substrates. Here we report the high-resolution crystal structure of a mononuclear non-haem side-on iron(III)–peroxo complex, [Fe(III)(TMC)(OO)]+. We also report a series of chemical reactions in which this iron(III)–peroxo complex is cleanly converted to the iron(III)–hydroperoxo complex, [Fe(III)(TMC)(OOH)]2+, via a short-lived intermediate on protonation. This iron(III)–hydroperoxo complex then cleanly converts to the ferryl complex, [Fe(IV)(TMC)(O)]2+, via homolytic O–O bond cleavage of the iron(III)–hydroperoxo species. All three of these iron species—the three most biologically relevant iron–oxygen intermediates—have been spectroscopically characterized; we note that they have been obtained using a simple macrocyclic ligand. We have performed relative reactivity studies on these three iron species which reveal that the iron(III)–hydroperoxo complex is the most reactive of the three in the deformylation of aldehydes and that it has a similar reactivity to the iron(IV)–oxo complex in C–H bond activation of alkylaromatics. These reactivity results demonstrate that iron(III)–hydroperoxo species are viable oxidants in both nucleophilic and electrophilic reactions by iron-containing enzymes. PMID:22031443

26 CFR 1.469-4 - Definition of activity.

Code of Federal Regulations, 2010 CFR

2010-04-01

... trade or business; or (iii) Involve research or experimental expenditures that are deductible under... or businesses; (ii) The extent of common control; (iii) The extent of common ownership; (iv... activities. Moreover, once C groups these activities into appropriate economic units, paragraph (e) of this...

26 CFR 1.469-4 - Definition of activity.

Code of Federal Regulations, 2014 CFR

2014-04-01

... trade or business; or (iii) Involve research or experimental expenditures that are deductible under... or businesses; (ii) The extent of common control; (iii) The extent of common ownership; (iv... activities. Moreover, once C groups these activities into appropriate economic units, paragraph (e) of this...

26 CFR 1.469-4 - Definition of activity.

Code of Federal Regulations, 2011 CFR

2011-04-01

... trade or business; or (iii) Involve research or experimental expenditures that are deductible under... or businesses; (ii) The extent of common control; (iii) The extent of common ownership; (iv... activities. Moreover, once C groups these activities into appropriate economic units, paragraph (e) of this...

26 CFR 1.469-4 - Definition of activity.

Code of Federal Regulations, 2013 CFR

2013-04-01

... trade or business; or (iii) Involve research or experimental expenditures that are deductible under... or businesses; (ii) The extent of common control; (iii) The extent of common ownership; (iv... activities. Moreover, once C groups these activities into appropriate economic units, paragraph (e) of this...

The effect of surface charge on the thermal stability and ice recrystallization inhibition activity of antifreeze protein III (AFP III).

PubMed

Deller, R C; Carter, B M; Zampetakis, I; Scarpa, F; Perriman, A W

2018-01-01

The aim of this study was to examine the effect of chemical cationization on the structure and function of antifreeze protein III (AFP III) over an extreme temperature range (-40°C to +90°C) using far-UV synchrotron radiation circular dichroism (SRCD) and ice recrystallization inhibition (IRI) assays. Chemical cationization was able to produce a modified AFP III with a net cationic charge at physiological pH that had enhanced resistance to denaturation at elevated temperatures, with no immediate negative impact on protein structure at subzero temperatures. Furthermore, cationized AFP III retained an IRI activity similar to that of native AFP III. Consequently, chemical cationization may provide a pathway to the development of more robust antifreeze proteins as supplementary cryoprotectants in the cryopreservation of clinically relevant cells. Copyright © 2017. Published by Elsevier Inc.

Is the evaluation of the anterior inferior iliac spine (AIIS) in the AP pelvis possible? Analysis of conventional X-rays and 3D-CT reconstructions.

PubMed

Krueger, David R; Windler, Markus; Geßlein, Markus; Schuetz, Michael; Perka, Carsten; Schroeder, Joerg H

2017-07-01

A hypertrophic AIIS has been identified as a cause for extraarticular hip impingement and is classified according to Hetsroni using 3D-CT reconstructions. The role of the conventional AP pelvis X-ray, which is the first standard imaging step for the evaluation of hip pain, has not been investigated yet. AP pelvis X-rays and 3D-CT reconstructions of patients were evaluated regarding their morphology of the AIIS. The conventional X-rays were categorized into three groups according to the projection of the AIIS: above (A) or below (B) the acetabular sourcil or even exceeding the anterior acetabular rim (C). They were compared to the morphologic types in the 3D-CT reconstruction (Hetsroni type I-III). Ninety patients with an equal distribution of type A, B or C projection in the AP pelvis were evaluated and compared to the morphology in the 3D-CT reconstruction. The projection of the AIIS below the acetabular sourcil (B + C) showed only moderate sensitivity (0.76) and specificity (0.64) for a hypertrophic AIIS (Hetsroni type II + III), but if the AIIS exceeds the anterior rim, all cases showed a hypertrophic AIIS in the 3D-CT reconstructions (Hetsroni type II + III). Distinct differentiation of the AIIS morphology in the AP pelvis is not possible, but the projection of the AIIS below the anterior acetabular rim represented a hypertrophic AIIS in all cases and should, therefore, be critically investigated for a relevant AIIS impingement.

Control of glioblastoma tumorigenesis by feed-forward cytokine signaling

PubMed Central

Jahani-Asl, Arezu; Yin, Hang; Soleimani, Vahab D; Haque, Takrima; Luchman, H Artee; Chang, Natasha C; Sincennes, Marie-Claude; Puram, Sidharth V; Scott, Andrew M; Lorimer, Ian A J; Perkins, Theodore J; Ligon, Keith L; Weiss, Samuel; Rudnicki, Michael A; Bonni, Azad

2016-01-01

EGFRvIII-STAT3 signaling is important in glioblastoma pathogenesis. Here, we identified the cytokine receptor OSMR as a direct target gene of the transcription factor STAT3 in mouse astrocytes and human brain tumor stem cells (BTSCs). We found that OSMR functioned as an essential co-receptor for EGFRvIII. OSMR formed a physical complex with EGFRvIII, and depletion of OSMR impaired EGFRvIII-STAT3 signaling. Conversely, pharmacological inhibition of EGFRvIII phosphorylation inhibited the EGFRvIII-OSMR interaction and activation of STAT3. EGFRvIII-OSMR signaling in tumors operated constitutively, whereas EGFR-OSMR signaling in nontumor cells was synergistically activated by the ligands EGF and OSM. Finally, knockdown of OSMR strongly suppressed cell proliferation and tumor growth of mouse glioblastoma cells and human BTSC xenografts in mice, and prolonged the lifespan of those mice. Our findings identify OSMR as a critical regulator of glioblastoma tumor growth that orchestrates a feed-forward signaling mechanism with EGFRvIII and STAT3 to drive tumorigenesis. PMID:27110918

The Positive Emotions after Acute Coronary Events behavioral health intervention: Design, rationale, and preliminary feasibility of a factorial design study.

PubMed

Huffman, Jeffery C; Albanese, Ariana M; Campbell, Kirsti A; Celano, Christopher M; Millstein, Rachel A; Mastromauro, Carol A; Healy, Brian C; Chung, Wei-Jean; Januzzi, James L; Collins, Linda M; Park, Elyse R

2017-04-01

Positive psychological constructs, such as optimism, are associated with greater participation in cardiac health behaviors and improved cardiac outcomes. Positive psychology interventions, which target psychological well-being, may represent a promising approach to improving health behaviors in high-risk cardiac patients. However, no study has assessed whether a positive psychology intervention can promote physical activity following an acute coronary syndrome. In this article we will describe the methods of a novel factorial design study to aid the development of a positive psychology-based intervention for acute coronary syndrome patients and aim to provide preliminary feasibility data on study implementation. The Positive Emotions after Acute Coronary Events III study is an optimization study (planned N = 128), subsumed within a larger multiphase optimization strategy iterative treatment development project. The goal of Positive Emotions after Acute Coronary Events III is to identify the ideal components of a positive psychology-based intervention to improve post-acute coronary syndrome physical activity. Using a 2 × 2 × 2 factorial design, Positive Emotions after Acute Coronary Events III aims to: (1) evaluate the relative merits of using positive psychology exercises alone or combined with motivational interviewing, (2) assess whether weekly or daily positive psychology exercise completion is optimal, and (3) determine the utility of booster sessions. The study's primary outcome measure is moderate-to-vigorous physical activity at 16 weeks, measured via accelerometer. Secondary outcome measures include psychological, functional, and adherence-related behavioral outcomes, along with metrics of feasibility and acceptability. For the primary study outcome, we will use a mixed-effects model with a random intercept (to account for repeated measures) to assess the main effects of each component (inclusion of motivational interviewing in the exercises, duration of the intervention, and inclusion of booster sessions) from a full factorial model controlling for baseline activity. Similar analyses will be performed on self-report measures and objectively-measured medication adherence over 16 weeks. We hypothesize that the combined positive psychology and motivational interviewing intervention, weekly exercises, and booster sessions will be associated with superior physical activity. Thus far, 78 participants have enrolled, with 72% of all possible exercises fully completed by participants. The Positive Emotions after Acute Coronary Events III study will help to determine the optimal content, intensity, and duration of a positive psychology intervention in post-acute coronary syndrome patients prior to testing in a randomized trial. This study is novel in its use of a factorial design within the multiphase optimization strategy framework to optimize a behavioral intervention and the use of a positive psychology intervention to promote physical activity in high-risk cardiac patients.

Arsenic Directly Binds to and Activates the Yeast AP-1-Like Transcription Factor Yap8

PubMed Central

Kumar, Nallani Vijay; Yang, Jianbo; Pillai, Jitesh K.; Rawat, Swati; Solano, Carlos; Kumar, Abhay; Grøtli, Morten; Stemmler, Timothy L.; Rosen, Barry P.

2015-01-01

The AP-1-like transcription factor Yap8 is critical for arsenic tolerance in the yeast Saccharomyces cerevisiae. However, the mechanism by which Yap8 senses the presence of arsenic and activates transcription of detoxification genes is unknown. Here we demonstrate that Yap8 directly binds to trivalent arsenite [As(III)] in vitro and in vivo and that approximately one As(III) molecule is bound per molecule of Yap8. As(III) is coordinated by three sulfur atoms in purified Yap8, and our genetic and biochemical data identify the cysteine residues that form the binding site as Cys132, Cys137, and Cys274. As(III) binding by Yap8 does not require an additional yeast protein, and Yap8 is regulated neither at the level of localization nor at the level of DNA binding. Instead, our data are consistent with a model in which a DNA-bound form of Yap8 acts directly as an As(III) sensor. Binding of As(III) to Yap8 triggers a conformational change that in turn brings about a transcriptional response. Thus, As(III) binding to Yap8 acts as a molecular switch that converts inactive Yap8 into an active transcriptional regulator. This is the first report to demonstrate how a eukaryotic protein couples arsenic sensing to transcriptional activation. PMID:26711267

Arsenic Directly Binds to and Activates the Yeast AP-1-Like Transcription Factor Yap8

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kumar, Nallani Vijay; Yang, Jianbo; Pillai, Jitesh K.

The AP-1-like transcription factor Yap8 is critical for arsenic tolerance in the yeastSaccharomyces cerevisiae. However, the mechanism by which Yap8 senses the presence of arsenic and activates transcription of detoxification genes is unknown. Here we demonstrate that Yap8 directly binds to trivalent arsenite [As(III)]in vitroandin vivoand that approximately one As(III) molecule is bound per molecule of Yap8. As(III) is coordinated by three sulfur atoms in purified Yap8, and our genetic and biochemical data identify the cysteine residues that form the binding site as Cys132, Cys137, and Cys274. As(III) binding by Yap8 does not require an additional yeast protein, and Yap8more » is regulated neither at the level of localization nor at the level of DNA binding. Instead, our data are consistent with a model in which a DNA-bound form of Yap8 acts directly as an As(III) sensor. Binding of As(III) to Yap8 triggers a conformational change that in turn brings about a transcriptional response. Thus, As(III) binding to Yap8 acts as a molecular switch that converts inactive Yap8 into an active transcriptional regulator. This is the first report to demonstrate how a eukaryotic protein couples arsenic sensing to transcriptional activation.« less

A Process Evaluation of Project Developmental Continuity, Interim Report VI: Recommendations for Continuing the Impact Study.

ERIC Educational Resources Information Center

Granville, Arthur; And Others

This interim report re-examines data on instrument suitability, comparability of groups, and adequacy of sample size in Year III of the process evaluation of Project Developmental Continuity (PDC) and offers preliminary recommendations concerning the feasibility of continuing the impact study. PDC is a Head Start demonstration program aimed at…

Tomorrow's Manpower Needs. Volume III, National Trends and Outlook: Occupational Employment. Bulletin No. 1606.

ERIC Educational Resources Information Center

Bureau of Labor Statistics (DOL), Washington, DC.

This publication is the third of four volumes of "Tomorrow's Manpower Needs," which are devoted to the subject of national, state, and area projections of manpower requirements. This volume presents information on the national employment trends and projected 1975 requirements for workers in nine major occupational groups and 40 selected…

Video Processes in Teacher Education Programs; Scope, Techniques, and Assessment. Multi-State Teacher Education Project, Monograph III.

ERIC Educational Resources Information Center

Bosley, Howard E.; And Others

"Video Processes Are Changing Teacher Education" by Howard Bosley (the first of five papers comprising this document) discusses the Multi-State Teacher Education Project (M-STEP) experimentation with media; it lists various uses of video processes, concentrating specifically on microteaching and the use of simulation and critical…

Project Success Environment: An Approach to Community Educational Improvement. End of Budget Report, Fiscal Year 1975.

ERIC Educational Resources Information Center

Rollins, Howard

Between 1970 and 1973, Project Success Environment, funded under Elementary Secondary Education Act Title III developed an effective, low-cost classroom management program for use in grades one through eight of public schools. The program provides students with maximum opportunity to experience, on an individual basis, success in school. Teachers…

MARINE SCIENCE FILM CATALOG. MOVIES, FILMSTRIPS, AND SLIDES.

ERIC Educational Resources Information Center

CHAPMAN, FRANK L.

THIS CATALOG CONTAINS ANNOTATED LISTINGS OF 16MM. FILMS, 35MM. FILMSTRIPS, AND 35MM. SLIDES FOR INSTRUCTIONAL USE IN THE MARINE SCIENCES. PARTS 1, 2, AND 3 LIST THOSE WHICH ARE AVAILABLE FROM THE CARTERET COUNTY MARINE SCIENCE PROJECT, AN ELEMENTARY AND SECONDARY EDUCATION ACT TITLE III PROJECT. PART 4 LISTS A-V MATERIALS AVAILABLE ON FREE LOAN…

Evaluating the Incorporation of Technology and Application Projects in the Higher Education Mathematics Classroom

ERIC Educational Resources Information Center

Schreyer-Bennethum, Lynn; Albright, Leonard

2011-01-01

We report the qualitative and quantitative results of incorporating interdisciplinary application projects and increasing the use of teaching with technology into Calculus I, II and III at the University of Colorado Denver. Minimal changes were made to the curriculum and minimal time was required of instructors to make the changes. Instructors…

76 FR 23574 - Combined Notice of Filings #1

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-27

... WDT SERV AG-Photon Solar 810 Wanamaker Ave Ontario Roof Top Solar Project to be effective 4/21/2011... Photon Solar 4850 E Airport Dr Ontario Roof Top Solar Project to be effective 4/21/2011. Filed Date: 04...: Southern California Edison Company submits tariff filing per 35.13(a)(2)(iii: SGIA WDT SERV AG Photon Solar...

OEO Programs for Migrant and Seasonal Farm Workers. Title IIIB EOA Projects.

ERIC Educational Resources Information Center

Office of Economic Opportunity, Washington, DC.

The major thrust of Title III-B (Economic Opportunity Act) programs is to prepare migrant and seasonal farm workers for upgraded jobs and to prepare entire farm worker families for alternatives to farm work if they so desire. These alternatives, supported through projects for adult heads of households, emphasize skill training in preparation for…

Northern Indian California Education Project; An Analysis of Responses by Practicing School Psychologists on a Pre-Questionaire.

ERIC Educational Resources Information Center

Tarbet, Don; Miles, Marilyn

School psychologists (13) representing the 6 counties served by the Northern Indian California Education Project (Title III, Elementary and Secondary Education Act) attended a workshop on January 14, 1972, at Humboldt State College. Also attending were Humboldt State personnel from the fields of education and psychology. The workshop was intended…

A Formative-Summative Evaluation Design for a State-Sponsored Program of Educational Experimentation.

ERIC Educational Resources Information Center

Kniefel, Tanya M.

An evaluation design created to provide information for a multiple-project program of educational experimentation is presented. Project SEED (State Experimentation in Educational Development) became an official education effort in North Carolina on July 1, 1971. Model for the program was that of the State's ESEA Title III program with certain…

Project Vitality; Phase III. A Program for the Handicapped.

ERIC Educational Resources Information Center

Santa Ana Unified School District, CA.

The 1972-73 school year Project VITALITY is described to provide coordinated work study career development for students in grades seven through 12 or equivalent ages who are legally assigned to the special programs, students in the Teen Mothers program, and those students dismissed from the educable mentally retarded program after August 1, 1969.…

Research and Development Project in Career Education. Final Report. Volume III.

ERIC Educational Resources Information Center

Washington State Coordinating Council for Occupational Education, Olympia.

The final volume in the report on the Research and Development Project in Career Education is in two parts. The first, "Interest Inventories, Tests, Surveys, and Scales: A Compilation," is by James T. Jurgens. It is designed to acquaint teachers and counselors with 66 interest measurement instruments that are presently on the market. For most,…

78 FR 49282 - Renewal of Agency Information Collection for Reporting Systems for Public Law 102-477...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-13

... System for Public Law 102-477 Demonstration Project authorized by OMB Control Number 1076-0135. This... OMB Control Number 1076-0135, Reporting System for Public Law 102-477 Demonstration Project. This... public review, we cannot guarantee that we will be able to do so. III. Data OMB Control Number: 1076-0135...

40 CFR 85.1403 - Particulate standard for pre-1994 model year urban buses effective at time of engine rebuild or...

Code of Federal Regulations, 2010 CFR

2010-07-01

... section. (iii)(A) Pre-rebuild particulate emission levels and projected post-rebuild particulate emission... specified in the following table. The appropriate particulate level, pre-rebuild or post-rebuild, shall be... of engine Pre-rebuild particulate level (g/bhp-hr) Projected post-rebuild particulate level (g/bhp-hr...

40 CFR 85.1403 - Particulate standard for pre-1994 model year urban buses effective at time of engine rebuild or...

Code of Federal Regulations, 2014 CFR

2014-07-01

... section. (iii)(A) Pre-rebuild particulate emission levels and projected post-rebuild particulate emission... specified in the following table. The appropriate particulate level, pre-rebuild or post-rebuild, shall be... of engine Pre-rebuild particulate level (g/bhp-hr) Projected post-rebuild particulate level (g/bhp-hr...

40 CFR 85.1403 - Particulate standard for pre-1994 model year urban buses effective at time of engine rebuild or...

Code of Federal Regulations, 2012 CFR

2012-07-01

... section. (iii)(A) Pre-rebuild particulate emission levels and projected post-rebuild particulate emission... specified in the following table. The appropriate particulate level, pre-rebuild or post-rebuild, shall be... of engine Pre-rebuild particulate level (g/bhp-hr) Projected post-rebuild particulate level (g/bhp-hr...

40 CFR 85.1403 - Particulate standard for pre-1994 model year urban buses effective at time of engine rebuild or...

Code of Federal Regulations, 2013 CFR

2013-07-01

... section. (iii)(A) Pre-rebuild particulate emission levels and projected post-rebuild particulate emission... specified in the following table. The appropriate particulate level, pre-rebuild or post-rebuild, shall be... of engine Pre-rebuild particulate level (g/bhp-hr) Projected post-rebuild particulate level (g/bhp-hr...

40 CFR 85.1403 - Particulate standard for pre-1994 model year urban buses effective at time of engine rebuild or...

Code of Federal Regulations, 2011 CFR

2011-07-01

... section. (iii)(A) Pre-rebuild particulate emission levels and projected post-rebuild particulate emission... specified in the following table. The appropriate particulate level, pre-rebuild or post-rebuild, shall be... of engine Pre-rebuild particulate level (g/bhp-hr) Projected post-rebuild particulate level (g/bhp-hr...

NASA EEE Parts and Advanced Interconnect Program (AIP)

NASA Technical Reports Server (NTRS)

Gindorf, T.; Garrison, A.

1996-01-01

none given From Program Objectives: I. Accelerate the readiness of new technologies through development of validation, assessment and test method/tools II. Provide NASA Projects infusion paths for emerging technologies III. Provide NASA Projects technology selection, application and validation guidelines for harware and processes IV. Disseminate quality assurance, reliability, validation, tools and availability information to the NASA community.

DOE tallies Class III oil recovery field projects

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1994-07-25

Here are details from midterm proposals submitted as part of the US Department of Energy's Class 3 oil recovery field demonstration candidate projects. All of the proposals emphasize dissemination of project details so that the results, if successful, can be applied widely in similar reservoirs. Project results will also be fed into a national petroleum technology transfer network. The proposals include: Gulf of Mexico, Gulf coast, offshore California, a California thermal, immiscible CO[sub 2], produced/potable water, microbial EOR, California diatomite, West Texas Spraberry field, and other Permian Basin fields.

Electronic Biosensors Based on III-Nitride Semiconductors.

PubMed

Kirste, Ronny; Rohrbaugh, Nathaniel; Bryan, Isaac; Bryan, Zachary; Collazo, Ramon; Ivanisevic, Albena

2015-01-01

We review recent advances of AlGaN/GaN high-electron-mobility transistor (HEMT)-based electronic biosensors. We discuss properties and fabrication of III-nitride-based biosensors. Because of their superior biocompatibility and aqueous stability, GaN-based devices are ready to be implemented as next-generation biosensors. We review surface properties, cleaning, and passivation as well as different pathways toward functionalization, and critically analyze III-nitride-based biosensors demonstrated in the literature, including those detecting DNA, bacteria, cancer antibodies, and toxins. We also discuss the high potential of these biosensors for monitoring living cardiac, fibroblast, and nerve cells. Finally, we report on current developments of covalent chemical functionalization of III-nitride devices. Our review concludes with a short outlook on future challenges and projected implementation directions of GaN-based HEMT biosensors.

Adsorption of Cr(III) on ozonised activated carbon. Importance of Cpi-cation interactions.

PubMed

Rivera-Utrilla, J; Sánchez-Polo, M

2003-08-01

The adsorption of Cr(III) in aqueous solution was investigated on a series of ozonised activated carbons, analysing the effect of oxygenated surface groups on the adsorption process. A study was carried out to determine the adsorption isotherms and the influence of the pH on the adsorption of this metal. The adsorption capacity and affinity of the adsorbent for Cr(III) increased with the increase in oxygenated acid groups on the surface of the activated carbon. These findings imply that electrostatic-type interactions predominate in the adsorption process, although the adsorption of Cr(III) on the original (basic) carbon indicates that other forces also participate in the adsorption process. Thus, the ionic exchange of protons in the -Cpi-H3O(+) interaction for Cr(III) accounts for the adsorption of cationic species in basic carbons with positive charge density. Study of the influence of pH on the adsorption of Cr(III) showed that, in each system, the maximum adsorption occurred when the charge of the carbon surface was opposite that of the species of Cr(III) present at the pH of the experiment. These results confirmed that electrostatic interactions predominate in the adsorption process.

42 CFR 403.724 - Valid election requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... acceptance of nonexcepted medical treatment is inconsistent with his or her sincere religious beliefs. (iii... GENERAL PROVISIONS SPECIAL PROGRAMS AND PROJECTS Religious Nonmedical Health Care Institutions-Benefits...

42 CFR 403.724 - Valid election requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... acceptance of nonexcepted medical treatment is inconsistent with his or her sincere religious beliefs. (iii... GENERAL PROVISIONS SPECIAL PROGRAMS AND PROJECTS Religious Nonmedical Health Care Institutions-Benefits...

42 CFR 403.724 - Valid election requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... acceptance of nonexcepted medical treatment is inconsistent with his or her sincere religious beliefs. (iii... GENERAL PROVISIONS SPECIAL PROGRAMS AND PROJECTS Religious Nonmedical Health Care Institutions-Benefits...

42 CFR 403.724 - Valid election requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... acceptance of nonexcepted medical treatment is inconsistent with his or her sincere religious beliefs. (iii... GENERAL PROVISIONS SPECIAL PROGRAMS AND PROJECTS Religious Nonmedical Health Care Institutions-Benefits...

42 CFR 403.724 - Valid election requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... acceptance of nonexcepted medical treatment is inconsistent with his or her sincere religious beliefs. (iii... GENERAL PROVISIONS SPECIAL PROGRAMS AND PROJECTS Religious Nonmedical Health Care Institutions-Benefits...

24 CFR 905.10 - Capital Fund formula (CFF).

Code of Federal Regulations, 2013 CFR

2013-04-01

... projects; (ii) Vacancy reduction; (iii) Addressing deferred maintenance needs and the replacement of obsolete utility systems and dwelling equipment; (iv) Planned code compliance; (v) Management improvements...

24 CFR 905.10 - Capital Fund formula (CFF).

Code of Federal Regulations, 2012 CFR

2012-04-01

... projects; (ii) Vacancy reduction; (iii) Addressing deferred maintenance needs and the replacement of obsolete utility systems and dwelling equipment; (iv) Planned code compliance; (v) Management improvements...

Strengthening the capacity for health promotion in South Africa through international collaboration.

PubMed

Van den Broucke, Stephan; Jooste, Heila; Tlali, Maki; Moodley, Vimla; Van Zyl, Greer; Nyamwaya, David; Tang, Kwok-Cho

2010-06-01

This paper describes a project to strengthen the capacity for health promotion in two Provinces in South Africa. The project draws on the key health promotion capacity dimensions of partnership and networking, infrastructure, problem-solving capacity, and knowledge transfer. The project was carried out in a partnership between the Provinces, the Ministry of Health of South Africa, the government of Flanders, Belgium, and the World Health Organization (WHO). The project aimed to: (i) integrate health promotion into national, Provincial and district level health policy plans (ii) strengthen the health promotion capacity in the two Provinces; and (iii) support the development of tools to monitor and evaluate health promotion interventions. Starting from a situation analysis and identification of priority health issues and existing actions in each Province, capacity-building workshops were organized for senior participants from various sectors. Community-based health promotion interventions were then planned and implemented in both Provinces. A systematic evaluation of the project involving an internal audit of project activities and results based on document analysis, site visits, focus groups and interviews with key persons demonstrated that stakeholders in both Provinces saw an increase of capacity in terms of networking, knowledge transfer, problem solving, and to a lesser extent infrastructure. Health promotion had been well integrated in the Provincial health plans, and roll-out processes with local stakeholders had started after the conclusion of the project. The development of tools for monitoring and evaluation of health promotion was less well achieved. The project illustrates how capacities to deliver health promotion interventions in a developing country can be enhanced through international collaboration. The conceptual model of capacity building that served as a basis for the project provided a useful framework to plan, identify and assess the key components of health promotion capacity in an African context.

Neuroprotective effects of metabotropic glutamate receptor group II and III activators against MPP(+)-induced cell death in human neuroblastoma SH-SY5Y cells: the impact of cell differentiation state.

PubMed

Jantas, D; Greda, A; Golda, S; Korostynski, M; Grygier, B; Roman, A; Pilc, A; Lason, W

2014-08-01

Recent studies have documented that metabotropic glutamate receptors from group II and III (mGluR II/III) are a potential target in the symptomatic treatment of Parkinson's disease (PD), however, the neuroprotective effects of particular mGluR II/III subtypes in relation to PD pathology are recognized only partially. In the present study, we investigated the effect of various mGluR II/III activators in the in vitro model of PD using human neuroblastoma SH-SY5Y cell line and mitochondrial neurotoxin MPP(+). We demonstrated that all tested mGluR ligands: mGluR II agonist - LY354740, mGluR III agonist - ACPT-I, mGluR4 PAM - VU0361737, mGluR8 agonist - (S)-3,4-DCPG, mGluR8 PAM - AZ12216052 and mGluR7 allosteric agonist - AMN082 were protective against MPP(+)-evoked cell damage in undifferentiated (UN-) SH-SY5Y cells with the highest neuroprotection mediated by mGluR8-specific agents. However, in retinoic acid- differentiated (RA-) SH-SY5Y cells we found protection mediated only by mGluR8 activators. We also demonstrated the cell proliferation stimulating effect for mGluR4 and mGluR8 PAMs. Next, we showed that the protection mediated by mGluR II/III activators in UN-SH-SY5Y was not accompanied by the modulation of caspase-3 activity, however, a decrease in the number of apoptotic nuclei was found. Finally, we showed that the inhibitor of necroptosis, necrostatin-1 blocked the mGluR III-mediated protection. Altogether our comparative in vitro data add a further proof to neuroprotective effects of mGluR agonists or PAMs and point to mGluR8 as a promising target for neuroprotective interventions in PD. The results also suggest the participation of necroptosis-related molecular pathways in neuroprotective effects of mGluR III activation. Copyright © 2014 Elsevier Ltd. All rights reserved.

Characterization of Fe (III)-reducing enrichment culture and isolation of Fe (III)-reducing bacterium Enterobacter sp. L6 from marine sediment.

PubMed

Liu, Hongyan; Wang, Hongyu

2016-07-01

To enrich the Fe (III)-reducing bacteria, sludge from marine sediment was inoculated into the medium using Fe (OH)3 as the sole electron acceptor. Efficiency of Fe (III) reduction and composition of Fe (III)-reducing enrichment culture were analyzed. The results indicated that the Fe (III)-reducing enrichment culture with the dominant bacteria relating to Clostridium and Enterobacter sp. had high Fe (III) reduction of (2.73 ± 0.13) mmol/L-Fe (II). A new Fe (III)-reducing bacterium was isolated from the Fe (III)-reducing enrichment culture and identified as Enterobacter sp. L6 by 16S rRNA gene sequence analysis. The Fe (III)-reducing ability of strain L6 under different culture conditions was investigated. The results indicated that strain L6 had high Fe (III)-reducing activity using glucose and pyruvate as carbon sources. Strain L6 could reduce Fe (III) at the range of NaCl concentrations tested and had the highest Fe (III) reduction of (4.63 ± 0.27) mmol/L Fe (II) at the NaCl concentration of 4 g/L. This strain L6 could reduce Fe (III) with unique properties in adaptability to salt variation, which indicated that it can be used as a model organism to study Fe (III)-reducing activity isolated from marine environment. Copyright © 2015 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

Strategies for Reforming Initial Vocational Education and Training in Europe. Final Report of the Project. Leonardo da Vinci/Transnational Pilot Projects: Multiplier Effect, Strand III.3.a. Sharpening Post-16 Education Strategies by Horizontal and Vertical Networking (1997-2000).

ERIC Educational Resources Information Center

Stenstrom, Marja-Leena, Ed.; Lasonen, Johanna, Ed.

This document contains 24 papers examining strategies for reforming initial vocational education and training (VET) in Europe. The following papers are included: "Reassessing VET Reform Strategies in a New Context: Implementation of the SPES-NET (Sharpening Post-16 Education Strategies by Horizontal and Vertical Networking) Project"…

Fatigue-related firing of muscle nociceptors reduces voluntary activation of ipsilateral but not contralateral lower limb muscles.

PubMed

Kennedy, David S; Fitzpatrick, Siobhan C; Gandevia, Simon C; Taylor, Janet L

2015-02-15

During fatiguing upper limb exercise, maintained firing of group III/IV muscle afferents can limit voluntary drive to muscles within the same limb. It is not known if this effect occurs in the lower limb. We investigated the effects of group III/IV muscle afferent firing from fatigued ipsilateral and contralateral extensor muscles and ipsilateral flexor muscles of the knee on voluntary activation of the knee extensors. In three experiments, we examined voluntary activation of the knee extensors by measuring changes in superimposed twitches evoked by femoral nerve stimulation. Subjects attended on 2 days for each experiment. On one day a sphygmomanometer cuff occluded blood flow of the fatigued muscles to maintain firing of group III/IV muscle afferents. After a 2-min extensor contraction (experiment 1; n = 9), mean voluntary activation was lower with than without maintained ischemia (47 ± 19% vs. 87 ± 8%, respectively; P < 0.001). After a 2-min knee flexor maximal voluntary contraction (MVC) (experiment 2; n = 8), mean voluntary activation was also lower with than without ischemia (59 ± 21% vs. 79 ± 9%; P < 0.01). After the contralateral (left) MVC (experiment 3; n = 8), mean voluntary activation of the right leg was similar with or without ischemia (92 ± 6% vs. 93 ± 4%; P = 0.65). After fatiguing exercise, activity in group III/IV muscle afferents reduces voluntary activation of the fatigued muscle and nonfatigued antagonist muscles in the same leg. However, group III/IV muscle afferents from the fatigued left leg had no effect on the unfatigued right leg. This suggests that any "crossover" of central fatigue in the lower limbs is not mediated by group III/IV muscle afferents. Copyright © 2015 the American Physiological Society.

Seven-Color Photometry and Classification of Stars in the Direction of Open Cluster M29 (NGC 6913) in Cygnus

DTIC Science & Technology

2013-01-01

Spitzer, 2MASS , VVISE and IPHAS databases is acknowledged. The project is partly supported by the Research Council of Lithuania, grant No. MIP-061/2013...1304. YSO [WISE, IPHAS]; 1305. HD 19򒵺 (A), B5V [5], B8III [6]; 1306. G5III [5[; 1307. WDS 20243+3811 (sep ~ 1.9"); 1313. YSO [ 2MASS , Spitze... 2MASS , IPHAS); 1387. Fl III [!6[; 1391. HD 229261 (B9), BS [5,8], B6II [16], B5IV-V [17[; 1407. F2 [5[; 1408. B3 V [16[; 1419. A2IV [16[; 1427

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shearer, J.; Callan, P; Amie, J

Nitrile hydratases (NHases) are non-heme Fe{sup III} or non-corrin Co{sup III} containing metalloenzymes that possess an N{sub 2}S{sub 3} ligand environment with nitrogen donors derived from amidates and sulfur donors derived from cysteinates. A closely related enzyme is thiocyanate hydrolase (SCNase), which possesses a nearly identical active-site coordination environment as CoNHase. These enzymes are redox inactive and perform hydrolytic reactions; SCNase hydrolyzes thiocyanate anions while NHase converts nitriles into amides. Herein an active CoNHase metallopeptide mimic, [Co{sup III}NHase-m1] (NHase-m1 = AcNH-CCDLP-CGVYD-PA-COOH), that contains Co{sup III} in a similar N{sub 2}S{sub 3} coordination environment as CoNHase is reported. [Co{sup III}NHase-m1] wasmore » characterized by electrospray ionization-mass spectrometry (ESI-MS), gel-permeation chromatography (GPC), Co K-edge X-ray absorption spectroscopy (Co-S: 2.21 {angstrom}; Co-N: 1.93 {angstrom}), vibrational, and optical spectroscopies. We find that [Co{sup III}NHase-m1] will perform the catalytic conversion of acrylonitrile into acrylamide with up to 58 turnovers observed after 18 h at 25 C (pH 8.0). FTIR data used in concert with calculated vibrational data (mPWPW91/aug-cc-TZVPP) demonstrates that the active form of [Co{sup III}NHase-m1] has a ligated SO{sub 2} (? = 1091 cm{sup -1}) moiety and a ligated protonated SO(H) (? = 928 cm{sup -1}) moiety; when only one oxygenated cysteinate ligand (i.e., a mono-SO{sub 2} coordination motif) or the bis-SO{sub 2} coordination motif are found within [Co{sup III}NHase-m1] no catalytic activity is observed. Calculations of the thermodynamics of ligand exchange (B3LYP/aug-cc-TZVPP) suggest that the reason for this is that the SO{sub 2}/SO(H) equatorial ligand motif promotes both water dissociation from the Co{sup III}-center and nitrile coordination to the Co{sup III}-center. In contrast, the under- or overoxidized motifs will either strongly favor a five coordinate Co{sup III}-center or strongly favor water binding to the Co{sup III}-center over nitrile binding.« less

Life after School: A Profile of Early Leavers in Newfoundland. Youth Transition into the Labour Market. Report and Summary Report.

ERIC Educational Resources Information Center

Spain, William H.; And Others

This project consists of two parallel yet interrelated studies, one focusing on the full cohort of approximately 9,000 Level III (Grade 12) high school students in Newfoundland and Labrador at the end of the 1988-89 school year, and a second, which focuses on the full year cohort of 2109 students (grades seven to Level III) who dropped out of…

Youth Transition into the Labour Market. The Class of '89: Initial Survey of Level III (Grade 12) High School Students.

ERIC Educational Resources Information Center

Sharpe, Dennis B.; Spain, William H.

The Transition of Youth into the Labour Market is a developmental study of youth as they make the difficult transition into the labor market of Newfoundland and Labrador. The project consists of two parallel yet interrelated studies, one focusing on the full cohort of over 9000 Level III high school students at the end of the 1988-89 school year,…

VizieR Online Data Catalog: APOGEE kinematics. I. Galactic bulge overview (Ness+, 2016)

NASA Astrophysics Data System (ADS)

Ness, M.; Zasowski, G.; Johnson, J. A.; Athanassoula, E.; Majewski, S. R.; Garcia Perez, A. E.; Bird, J.; Nidever, D.; Schneider, D. P.; Sobeck, J.; Frinchaboy, P.; Pan, K.; Bizyaev, D.; Oravetz, D.; Simmons, A.

2016-05-01

We use the APOGEE spectra (R=22500) from the SDSS-III Data Release 12 (DR12; Ahn et al. 2014ApJS..211...17A) for about 20000 stars toward the Galactic bulge and surrounding disk. The APOGEE survey, part of the SDSS-III project (Eisenstein et al. 2011AJ....142...72E), operates at the 2.5m telescope of the Apache Point Observatory. (1 data file).

General Improvement of Reading Instruction, Grades 1-12, Teacher Training Program of Title III, P.L. 89-10. Evaluation of Second Phase of Program, Summer 1968.

ERIC Educational Resources Information Center

Brookland-Cayce Schools, West Columbia, SC.

An evaluation of the second phase of a projected 3-year Title III inservice reading instruction program for teaching personnel is presented after one and one-half years of operation in 16 Cayce-West Columbia, South Carolina, schools. Included is an evaluation prepared by each of the 11 elementary supervisors which includes objectives and how they…

Installation Restoration Program Records Search for Westover Air Force Base, Massachusetts.

DTIC Science & Technology

1982-04-01

Phase III (not part of this contract) consists of a technology base development study to support the development of project plans for controlling...determine the extent and magnitude of the contaminant migration. Phase III (not part of this contract) consists of a technology base development study to...number of vegetation studies have attempted to classify the potential climax vegetation within the region of Westover AFB (Braun, 1972; Kuchler, 1975

Big River Reservoir Project - Pawcatuck River and Narragansett Bay Drainage Basins - Water and Related Land Resources Study. Volume III. Appendices H-K.

DTIC Science & Technology

1981-07-01

including a recreation impact analysis, aquatic and terrestrial ecosystems assessment and a fish and wildlife management plan), social and cultural...APPENDIX G - DESIGN AND COST ESTIMATES VOLUME III - APPENDIX H - RECREATION AND NATURAL RESOURCES Section 1 - Recreation Impact Analysis Section 2 - Aquatic... Ecosystem Assessment Section 3 - Terrestrial Ecosystem Assessment Section 4 - Fish and Wildlife Management Plan APPENDIX I - SOCIAL AND CULTURAL

Polymer-Supported Optically Active fac(S)-Tris(thiotato)rhodium(III) Complex for Sulfur-Bridging Reaction With Precious Metal Ions.

PubMed

Aizawa, Sen-Ichi; Tsubosaka, Soshi

2016-01-01

The optically active mixed-ligand fac(S)-tris(thiolato)rhodium(III) complexes, ΔL -fac(S)-[Rh(aet)2 (L-cys-N,S)](-) (aet = 2-aminoethanethiolate, L-cys = L-cysteinate) () and ΔLL -fac(S)-[Rh(aet)(L-cys-N,S)2 ](2-) were newly prepared by the equatorial preference of the carboxyl group in the coordinated L-cys ligand. The amide formation reaction of with 1,10-diaminodecane and polyallylamine gave the diamine-bridged dinuclear Rh(III) complex and the single-chain polymer-supported Rh(III) complex with retention of the ΔL configuration of , respectively. These Rh(III) complexes reacted with Co(III) or Co(II) to give the linear-type trinuclear structure with the S-bridged Co(III) center and the two Δ-Rh(III) terminal moieties. The polymer-supported Rh(III) complex was applied not only to the CD spectropolarimetric detection and determination of a trace of precious metal ions such as Au(III), Pt(II), and Pd(II) but also to concentration and extraction of these metal ions into the solid polymer phase. Chirality 28:85-91, 2016. © 2015 Wiley Periodicals, Inc. © 2015 Wiley Periodicals, Inc.

Diagnostic value of succinate ubiquinone reductase activity in the identification of patients with mitochondrial DNA depletion.

PubMed

Hargreaves, P; Rahman, S; Guthrie, P; Taanman, J W; Leonard, J V; Land, J M; Heales, S J R

2002-02-01

Mitochondrial DNA (mtDNA) depletion syndrome (McKusick 251880) is characterized by a progressive quantitative loss of mtDNA resulting in severe mitochondrial dysfunction. A diagnosis of mtDNA depletion can only be confirmed after Southern blot analysis of affected tissue. Only a limited number of centres have the facilities to offer this service, and this is frequently on an irregular basis. There is therefore a need for a test that can refine sample selection as well as complementing the molecular analysis. In this study we compared the activities of the nuclear-encoded succinate ubiquinone reductase (complex II) to the activities of the combined mitochondrial and nuclear-encoded mitochondrial electron transport chain (ETC) complexes; NADH:ubiquinone reductase (complex I), ubiquinol-cytochrome-c reductase (complex III), and cytochrome-c oxidase (complex IV), in skeletal muscle biopsies from 7 patients with confirmed mtDNA depletion. In one patient there was no evidence of an ETC defect. However, the remaining 6 patients exhibited reduced complex I and IV activities. Five of these patients also displayed reduced complex II-III (succinate:cytochrome-c reductase) activity. Individual measurement of complex II and complex III activities demonstrated normal levels of complex II activity compared to complex III, which was reduced in the 5 biopsies assayed. These findings suggest a possible diagnostic value for the detection of normal levels of complex II activity in conjunction with reduced complex I, III and IV activity in the identification of likely candidates for mtDNA depletion syndrome

Short-term and long-term treatment outcomes with Class III activator

PubMed Central

Ryu, Hyo-kyung; Chong, Hyun-Jeong; An, Ki-Yong

2015-01-01

Objective The purpose of this retrospective study was to investigate short-term and long-term skeletodental outcomes of Class III activator treatment. Methods A Class III activator treatment group (AG) comprised of 22 patients (9 boys, 13 girls) was compared with a Class III control group (CG) comprised of 17 patients (6 boys, 11 girls). The total treatment period was divided into three stages; the initial stage (T1), the post-activator treatment or post-mandibular growth peak stage (T2), and the long-term follow-up stage (T3). Cephalometric changes were evaluated statistically via the Mann-Whitney U-test and the Friedman test. Results The AG exhibited significant increases in the SNA angle, ANB angle, Wits appraisal, A point-N perpendicular, Convexity of A point, and proclination of the maxillary incisors, from T1 to T2. In the long-term follow-up (T1-T3), the AG exhibited significantly greater increases in the ANB angle, Wits appraisal, and Convexity of A point than the CG. Conclusions Favorable skeletal outcomes induced during the Class III activator treatment period were generally maintained until the long-term follow-up period of the post-mandibular growth peak stage. PMID:26445717

PandaX-III: Searching for neutrinoless double beta decay with high pressure 136Xe gas time projection chambers

NASA Astrophysics Data System (ADS)

Chen, Xun; Fu, ChangBo; Galan, Javier; Giboni, Karl; Giuliani, Franco; Gu, LingHui; Han, Ke; Ji, XiangDong; Lin, Heng; Liu, JiangLai; Ni, KaiXiang; Kusano, Hiroki; Ren, XiangXiang; Wang, ShaoBo; Yang, Yong; Zhang, Dan; Zhang, Tao; Zhao, Li; Sun, XiangMing; Hu, ShouYang; Jian, SiYu; Li, XingLong; Li, XiaoMei; Liang, Hao; Zhang, HuanQiao; Zhao, MingRui; Zhou, Jing; Mao, YaJun; Qiao, Hao; Wang, SiGuang; Yuan, Ying; Wang, Meng; Khan, Amir N.; Raper, Neill; Tang, Jian; Wang, Wei; Dong, JiaNing; Feng, ChangQing; Li, Cheng; Liu, JianBei; Liu, ShuBin; Wang, XiaoLian; Zhu, DanYang; Castel, Juan F.; Cebrián, Susana; Dafni, Theopisti; Garza, Javier G.; Irastorza, Igor G.; Iguaz, Francisco J.; Luzón, Gloria; Mirallas, Hector; Aune, Stephan; Berthoumieux, Eric; Bedfer, Yann; Calvet, Denis; d'Hose, Nicole; Delbart, Alain; Diakaki, Maria; Ferrer-Ribas, Esther; Ferrero, Andrea; Kunne, Fabienne; Neyret, Damien; Papaevangelou, Thomas; Sabatié, Franck; Vanderbroucke, Maxence; Tan, AnDi; Haxton, Wick; Mei, Yuan; Kobdaj, Chinorat; Yan, Yu-Peng

2017-06-01

Searching for the neutrinoless double beta decay (NLDBD) is now regarded as the topmost promising technique to explore the nature of neutrinos after the discovery of neutrino masses in oscillation experiments. PandaX-III (particle and astrophysical xenon experiment III) will search for the NLDBD of 136Xe at the China Jin Ping Underground Laboratory (CJPL). In the first phase of the experiment, a high pressure gas Time Projection Chamber (TPC) will contain 200 kg, 90% 136Xe enriched gas operated at 10 bar. Fine pitch micro-pattern gas detector (Microbulk Micromegas) will be used at both ends of the TPC for the charge readout with a cathode in the middle. Charge signals can be used to reconstruct the electron tracks of the NLDBD events and provide good energy and spatial resolution. The detector will be immersed in a large water tank to ensure 5 m of water shielding in all directions. The second phase, a ton-scale experiment, will consist of five TPCs in the same water tank, with improved energy resolution and better control over backgrounds.

Biological activity of Fe(III) aquo-complexes towards ferric chelate reductase (FCR).

PubMed

Escudero, Rosa; Gómez-Gallego, Mar; Romano, Santiago; Fernández, Israel; Gutiérrez-Alonso, Ángel; Sierra, Miguel A; López-Rayo, Sandra; Nadal, Paloma; Lucena, Juan J

2012-03-21

In this study we have obtained experimental evidence that confirms the high activity of aquo complexes III and IV towards the enzyme FCR, responsible for the reduction of Fe(III) to Fe(II) in the process of iron acquisition by plants. The in vivo FCR assays in roots of stressed cucumber plants have shown a higher efficiency of the family of complexes III and a striking structure-activity relationship with the nature of the substituent placed in a phenyl group far away from the metal center. The results obtained in this work demonstrate that all the aquo compounds tested interact efficiently with the enzyme FCR and hence constitute a new concept of iron chelates that could be of great use in agronomy.

Nrf2 protects human bladder urothelial cells from arsenite and monomethylarsonous acid toxicity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang Xiaojun; Sun Zheng; Chen Weimin

2007-12-01

Arsenic is widely spread in our living environment and imposes a big challenge on human health worldwide. Arsenic damages biological systems through multiple mechanisms including the generation of reactive oxygen species. The transcription factor Nrf2 regulates the cellular antioxidant response that protects cells from various insults. In this study, the protective role of Nrf2 in arsenic toxicity was investigated in a human bladder urothelial cell line, UROtsa. Using a UROtsa cell line stably infected with Nrf2-siRNA, we clearly demonstrate that compromised Nrf2 expression sensitized the cells to As(III)- and MMA(III)-induced toxicity. On the other hand, the activation of the Nrf2more » pathway by tert-butylhydroquinone (tBHQ) and sulforaphane (SF), the known Nrf2-inducers, rendered UROtsa cells more resistant to As(III) and MMA(III). Furthermore, the wild-type mouse embryo fibroblast (WT-MEF) cells were protected from As(III)- and MMA(III)-induced toxicity following Nrf2 activation by tBHQ or SF, whereas neither tBHQ nor SF conferred protection in the Nrf2{sup -/-}MEF cells, demonstrating that tBHQ- or SF-mediated protection against As(III)- and MMA(III)-induced toxicity depends on Nrf2 activation. These results, obtained by both loss of function and gain of function analyses, clearly demonstrate the protective role of Nrf2 in arsenic-induced toxicity. The current work lays the groundwork for using Nrf2 activators for therapeutic and dietary interventions against adverse effects of arsenic.« less

Multinational Activities of Major U.S. Automotive Producers : Volume 3. Research, Development, and Engineering Abroad

DOT National Transportation Integrated Search

1978-09-01

This is Volume III of the report on the multinational activities of the four major U.S. automotive producers. The primary objective of Volume III is to evaluate the RD&E activities performed abroad by the U.S. automotive multinationals in order to de...

Comparative risk assessment of spill response options for a deepwater oil well blowout: Part III. Stakeholder engagement.

PubMed

Walker, Ann Hayward; Scholz, Debra; McPeek, Melinda; French-McCay, Deborah; Rowe, Jill; Bock, Michael; Robinson, Hilary; Wenning, Richard

2018-05-25

This paper describes oil spill stakeholder engagement in a recent comparative risk assessment (CRA) project that examined the tradeoffs associated with a hypothetical offshore well blowout in the Gulf of Mexico, with a specific focus on subsea dispersant injection (SSDI) at the wellhead. SSDI is a new technology deployed during the Deepwater Horizon (DWH) oil spill response. Oil spill stakeholders include decision makers, who will consider whether to integrate SSDI into future tradeoff decisions. This CRA considered the tradeoffs associated with three sets of response strategies: (1) no intervention; (2) mechanical recovery, in-situ burning, and surface dispersants; and, (3) SSDI in addition to responses in (2). For context, the paper begins with a historical review of U.S. policy and engagement with oil spill stakeholders regarding dispersants. Stakeholder activities throughout the project involved decision-maker representatives and their advisors to inform the approach and consider CRA utility in future oil spill preparedness. Copyright © 2018 Elsevier Ltd. All rights reserved.

Cardiac Epithelial-Mesenchymal Transition Is Blocked by Monomethylarsonous Acid (III)

PubMed Central

Huang, Tianfang; Barnett, Joey V.; Camenisch, Todd D.

2014-01-01

Arsenic exposure during embryonic development can cause ischemic heart pathologies later in adulthood which may originate from impairment in proper blood vessel formation. The arsenic-associated detrimental effects are mediated by arsenite (iAsIII) and its most toxic metabolite, monomethylarsonous acid [MMA (III)]. The impact of MMA (III) on coronary artery development has not yet been studied. The key cellular process that regulates coronary vessel development is the epithelial-mesenchymal transition (EMT). During cardiac EMT, activated epicardial progenitor cells transform to mesenchymal cells to form the cellular components of coronary vessels. Smad2/3 mediated TGFβ2 signaling, the key regulator of cardiac EMT, is disrupted by arsenite exposure. In this study, we compared the cardiac toxicity of MMA (III) with arsenite. Epicardial progenitor cells are 15 times more sensitive to MMA (III) cytotoxicity when compared with arsenite. MMA (III) caused a significant blockage in epicardial cellular transformation and invasion at doses 10 times lower than arsenite. Key EMT genes including TGFβ ligands, TβRIII, Has2, CD44, Snail1, TBX18, and MMP2 were down regulated by MMA (III) exposure. MMA (III) disrupted Smad2/3 activation at a dose 20 times lower than arsenite. Both arsenite and MMA (III) significantly inhibited Erk1/2 and Erk5 phosphorylation. Nuclear translocation of Smad2/3 and Erk5 was also blocked by arsenical exposure. However, p38 activation, as well as smooth muscle differentiation, was refractory to the inhibition by the arsenicals. Collectively, these findings revealed that MMA (III) is a selective disruptor of cardiac EMT and as such may predispose to arsenic-associated cardiovascular disorders. PMID:25145660

Batch sorption-desorption of As(III) from waste water by magnetic palm kernel shell activated carbon using optimized Box-Behnken design

NASA Astrophysics Data System (ADS)

Anyika, Chinedum; Asri, Nur Asilayana Mohd; Majid, Zaiton Abdul; Jaafar, Jafariah; Yahya, Adibah

2017-12-01

In this study, we converted activated carbon (AC) into magnetic activated carbon (MAC), which was established to have removed arsenic (III) from wastewater. Arsenic (III) is a toxic heavy metal which is readily soluble in water and can be detrimental to human health. The MAC was prepared by incorporating Fe3O4 into the AC by using Fe3O4 extracted from a ferrous sulfate solution, designated: magnetic palm kernel shell from iron suspension (MPKSF). Batch experiments were conducted using two methods: (1) one-factor-at-a-time and (2) Box-Behnken statistical analysis. Results showed that the optimum conditions resulted in 95% of As(III) removal in the wastewater sample. The adsorption data were best fitted to the Langmuir isotherm. The adsorption of As(III) onto the MPKSF was confirmed by energy dispersive X-ray spectrometry analysis which detected the presence of As(III) of 0.52% on the surface of the MPKSF. The Fourier transform infrared spectroscopy analysis of the MPKSF-As presented a peak at 573 cm-1, which was assigned to M-O (metal-oxygen) bending, indicating the coordination of As(III) with oxygen through the formation of inner-sphere complexation, thereby indicating a covalent bonding between the MPKSF functional groups and As(III). The findings suggested that the MPKSF exhibited a strong capacity to efficiently remove As(III) from wastewater, while the desorption studies showed that the As(III) was rigidly bound to the MPKSF thereby eliminating the possibility of secondary pollution.

Platelet-derived chemokines CXC chemokine ligand (CXCL)7, connective tissue-activating peptide III, and CXCL4 differentially affect and cross-regulate neutrophil adhesion and transendothelial migration.

PubMed

Schenk, Birgit I; Petersen, Frank; Flad, Hans-Dieter; Brandt, Ernst

2002-09-01

In this study, we have examined the major platelet-derived CXC chemokines connective tissue-activating peptide III (CTAP-III), its truncation product neutrophil-activating peptide 2 (CXC chemokine ligand 7 (CXCL7)), as well as the structurally related platelet factor 4 (CXCL4) for their impact on neutrophil adhesion to and transmigration through unstimulated vascular endothelium. Using monolayers of cultured HUVEC, we found all three chemokines to promote neutrophil adhesion, while only CXCL7 induced transmigration. Induction of cell adhesion following exposure to CTAP-III, a molecule to date described to lack neutrophil-stimulating capacity, depended on proteolytical conversion of the inactive chemokine into CXCL7 by neutrophils. This was evident from experiments in which inhibition of the CTAP-III-processing protease and simultaneous blockade of the CXCL7 high affinity receptor CXCR-2 led to complete abrogation of CTAP-III-mediated neutrophil adhesion. CXCL4 at substimulatory dosages modulated CTAP-III- as well as CXCL7-induced adhesion. Although cell adhesion following exposure to CTAP-III was drastically reduced, CXCL7-mediated adhesion underwent significant enhancement. Transendothelial migration of neutrophils in response to CXCL7 or IL-8 (CXCL8) was subject to modulation by CTAP-III, but not CXCL4, as seen by drastic desensitization of the migratory response of neutrophils pre-exposed to CTAP-III, which was paralleled by selective down-modulation of CXCR-2. Altogether our results demonstrate that there exist multiple interactions between platelet-derived chemokines in the regulation of neutrophil adhesion and transendothelial migration.

Associations of anthropometry and lifestyle factors with HDL subspecies according to apolipoprotein C-III[S

PubMed Central

Koch, Manja; Furtado, Jeremy D.; Jiang, Gordon Z.; Gray, Brianna E.; Cai, Tianxi; Sacks, Frank; Tjønneland, Anne; Overvad, Kim; Jensen, Majken K.

2017-01-01

The presence of apoC-III on HDL impairs HDL’s inverse association with coronary heart disease (CHD). Little is known about modifiable factors explaining variation in HDL subspecies defined according to apoC-III. The aim was to investigate cross-sectional associations of anthropometry and lifestyle with HDL subspecies in 3,631 participants from the Diet, Cancer, and Health study originally selected for a case-cohort study (36% women; age 50–65 years) who were all free of CHD. Greater adiposity and less activity were associated with higher HDL containing apoC-III and lower HDL lacking apoC-III. Per each 15 cm higher waist circumference, the level of HDL containing apoC-III was 2.8% higher (95% CI: 0.4, 5.3; P = 0.024) and the level of HDL not containing apoC-III was 4.7% lower (95% CI: −6.0, −3.4; P = <0.0001). Associations for physical activity were most robust to multivariable modeling. Each 20 metabolic equivalent task hours per week reported higher physical activity was associated with 0.9% (95% CI: −1.7, −0.1; P = 0.031) lower HDL containing apoC-III and 0.5% higher (95% CI: 0.1, 1.0; P = 0.029) HDL lacking apoC-III. Lower alcohol consumption was associated with lower HDL lacking apoC-III (percent difference per 15 g/day: 1.58 (95% CI: 0.84, 2.32; P = <0.0001). Adiposity and sedentary lifestyle were associated with a less favorable HDL subspecies profile. PMID:28365588

Low-Cost III-V Photovoltaic Materials by Chloride Vapor Transport Deposition Using Safe Solid Precursors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Boettcher, Shannon; Aloni, Shaul; Weiss, Robert

Si-based photovoltaic devices dominate the market. As photovoltaic (PV) manufacturing costs have plummeted, technologies which increase efficiency have become critical. Si cell efficiencies are nearing theoretical limits and Si-based PV modules are unlikely to reach the 25-30% efficiency range. The use of III-V semiconductors is an obvious technical solution to improve efficiency, especially if they can be integrated directly with existing Si technology as tandems. High coefficients of light absorption along with tunable bandgaps and lattice constants have resulted in record conversion efficiencies for both one-sun and concentrator PV applications. GaAs, for example, has been used to manufacture single-junction photovoltaicsmore » with world-record efficiencies of 28.8% at one sun.2 However, costs for III-Vs must be dramatically reduced to produce cost-effective, high-efficiency PV solutions. III-V costs are controlled by two factors: semiconductor growth and the substrate. III-V growth is dominated today by metal-organic vapor phase epitaxy (MOVPE) with a lesser role played by molecular beam epitaxy (MBE). MOVPE costs are high due to the expense and low utilization (~30%) of precursors, modest growth rates (~100 nm min-1), equipment complexity, and safety infrastructure needed to handle toxic, pyrophoric gases.3 MBE costs are high due to slow growth rates and limitations of scalability. Details comparing plausible low-cost III-V growth methods are available in a review article published as a result of this project. The primary goal of this project was to demonstrate that close-spaced vapor transport (CSVT) using chloride (from HCl) as a transport agent can be used for the rapid growth of device-ready III-V layers from safe, solid-source precursors. In pursuit of this goal, we designed, built, and installed a new Cl-CSVT reactor based on insights from our previous H2O-CSVT growth system and in collaboration with equipment professionals at Malachite Technologies. This system was successfully used to grow epitaxial GaAs with controlled n-type doping, having mobilities similar to MOVPE. Detailed technical information and results can also be found in the primary publication resulting from this project. This work sets the stage for tackling the development of high-performance III-V single junctions and tandem devices directly on Si substrates, which was beyond the capabilities of our H2O-CSVT system. The design of the reactor’s source and substrate transfer system should allow for direct deposition of device structures. The collective innovations of our Cl-CSVT system might ultimately serve as an enabling process for commercialization of the technology through a collaboration with appropriate industrial partners.« less

Antithrombin III in animal models of sepsis and organ failure.

PubMed

Dickneite, G

1998-01-01

Antithrombin III (AT III) is the physiological inhibitor of thrombin and other serine proteases of the clotting cascade. In the development of sepsis, septic shock and organ failure, the plasma levels of AT III decrease considerably, suggesting the concept of a substitution therapy with the inhibitor. A decrease of AT III plasma levels might also be associated with other pathological disorders like trauma, burns, pancreatitis or preclampsia. Activation of coagulation and consumption of AT III is the consequence of a generalized inflammation called SIRS (systemic inflammatory response syndrome). The clotting cascade is also frequently activated after organ transplantation, especially if organs are grafted between different species (xenotransplantation). During the past years AT III has been investigated in numerous corresponding disease models in different animal species which will be reviewed here. The bulk of evidence suggests, that AT III substitution reduces morbidity and mortality in the diseased animals. While gaining more experience with AT III, the concept of substitution therapy to maximal baseline plasma levels (100%) appears to become insufficient. Evidence from clinical and preclinical studies now suggests to adjust the AT III plasma levels to about 200%, i.e., doubling the normal value. During the last few years several authors proposed that AT III might not only be an anti-thrombotic agent, but to have in addition an anti-inflammatory effect.