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Sample records for activity leads students

  1. Effective Teachers for Students with Emotional/Behavioral Disorders: Active Ingredients Leading to Positive Teacher and Student Outcomes

    ERIC Educational Resources Information Center

    Conroy, Maureen A.; Sutherland, Kevin S.

    2012-01-01

    Teachers of students with emotional/behavioral disorders (E/BD) have varied skills and abilities. Within the field there are some teachers, who teach students with E/BD by actively engaging them in learning tasks and who have few behavior problems in comparison to other teachers, who struggle with classroom management. Many researchers have found…

  2. Introduction to the Symposium "Leading Students and Faculty to Quantitative Biology through Active Learning".

    PubMed

    Waldrop, Lindsay D; Miller, Laura A

    2015-11-01

    The broad aim of this symposium and set of associated papers is to motivate the use of inquiry-based, active-learning teaching techniques in undergraduate quantitative biology courses. Practical information, resources, and ready-to-use classroom exercises relevant to physicists, mathematicians, biologists, and engineers are presented. These resources can be used to address the lack of preparation of college students in STEM fields entering the workforce by providing experience working on interdisciplinary and multidisciplinary problems in mathematical biology in a group setting. Such approaches can also indirectly help attract and retain under-represented students who benefit the most from "non-traditional" learning styles and strategies, including inquiry-based, collaborative, and active learning. PMID:26269461

  3. Lead (Environmental Health Student Portal)

    MedlinePlus

    ... have lead in them The good news about lead poisoning is that it’s 100% preventable. That means we ... damage the brain, and may even cause death. Lead poisoning can also cause: Anemia (when your blood doesn’ ...

  4. Leading Students to a World of Interdependence.

    ERIC Educational Resources Information Center

    Carr, Kate

    2001-01-01

    Discusses the importance of maintaining links between school children and the outdoors. By creatively looking for outreach programs and simple animal activities, teachers can keep students' innate interest in nature alive. Studying nature can also teach students about interdependence. (SAH)

  5. Student Activities. Managing Liability.

    ERIC Educational Resources Information Center

    Bennett, Barbara; And Others

    This monograph suggests ways that college or university administrations can undertake a systematic and careful review of the risks posed by students' activities. Its purpose is to provide guidance in integrating the risk management process into a school's existing approaches to managing student organizations and activities. It is noted that no…

  6. Leading Student Groups to the Soviet Union.

    ERIC Educational Resources Information Center

    Winokur, Marshall

    1981-01-01

    Describes student tours to the Soviet Union, discussing the benefits to be derived from such experiences by both students and leaders. In particular, discusses the organization of the tours, their types and costs, advertising strategies, suggested itineraries and guidebooks, student orientation and group composition, and problems encountered…

  7. Project Lead the Way Students More Prepared for Higher Education

    ERIC Educational Resources Information Center

    Van Overschelde, James P.

    2013-01-01

    Project Lead the Way (PLTW) is a hands-on, project-based engineering curriculum for high school and middle school students, which has quadrupled annual enrollment in Texas in five years to over 23,000 students. The diversity of students participating has also increased dramatically. Using six years of longitudinally-linked student data, the…

  8. Lead-Bismuth Activities at the Karlsruhe Lead Laboratory KALLA

    SciTech Connect

    Knebel, Joachim U.; Muller, Georg; Konys, Jurgen

    2002-07-01

    At Forschungszentrum Karlsruhe (FZK) the characteristics of an accelerator-driven subcritical system (ADS) are evaluated, mainly with respect to the potential of transmutation of minor actinides and long-lived fission products, to the feasibility and to safety aspects. All experimental activities, which are related to lead-bismuth as cooling fluid and spallation material, are performed in the Karlsruhe Lead Laboratory KALLA. This article gives an overview on KALLA, which has three stagnant experiments and three loop experiments. The stagnant experiments are concentrating on corrosion mechanisms, surface treatment, oxygen sensor development, and oxygen control system (OCS), the loop experiments are concentrating on thermalhydraulic measurement techniques, ADS-relevant component testing, and corrosion investigations in flowing lead-bismuth. A fourth loop experiment is planned to investigate the integral heat removal from a 4 MW spallation target for normal and decay heat removal conditions. Among others, latest results are presented of: characteristics of oxygen sensors in flowing liquid Pb-Bi, the oxygen control system (OCS) operating on a loop system, an ultrasonic flow meter applied to lead-bismuth at 400 deg. C. In addition, results are given on the improvement of the corrosion resistivity of steels in flowing lead-bismuth, using a special temperature treatment method (electron beam facility GESA) and alloying aluminium in the surface layer. (authors)

  9. Motivating Activities that Lead to Algebra

    ERIC Educational Resources Information Center

    Menon, Ramakrishnan

    2004-01-01

    Four activities consisting of puzzles are introduced, which help students to recognize the strength of algebraic generalizations. They also assist them to comprehend algebraic concepts, and enable them to develop their individual puzzles and games.

  10. Does University Campus Experience Develop Motivation to Lead or Readiness to Lead among Undergraduate Students? "A Malaysian Perspective"

    ERIC Educational Resources Information Center

    Hamid, Jamaliah Abdul; Krauss, Steven E.

    2013-01-01

    Do students' experiences on university campuses cultivate motivation to lead or a sense of readiness to lead that does not necessarily translate to active leadership? To address this question, a study was conducted with 369 undergraduates from Malaysia. Campus experience was more predictive of leadership readiness than motivation. Student…

  11. Lead Capcom Hal Getzelman Talks With Students

    NASA Video Gallery

    From the International Space Station Flight Control Room, Capcom Chief Engineer Hal Getzelman participates in a Digital Learning Network (DLN) event with students from Clark Creek STEM Academy in A...

  12. Active Students in Webinars

    ERIC Educational Resources Information Center

    Kolås, Line; Nordseth, Hugo; Yri, Jørgen Sørlie

    2015-01-01

    To ensure student activity in webinars we have defined 10 learning tasks focusing on production and communication e.g. collaborative writing, discussion and polling, and investigated how the technology supports the learning activities. The three project partners in the VisPed-project use different video-conferencing systems, and we analyzed how it…

  13. Propelling Students into Active Grammar Participation

    ERIC Educational Resources Information Center

    Jurhill, Dennis A.

    2011-01-01

    "O! this learning, what a thing it is." -W. Shakespeare, "The Taming of the Shrew." The aim of this action research was to find out if active grammar involvement amongst students might lead to better results. My approach was to activate my students during grammar instruction by using cooperative learning: that is a form of learning in which…

  14. Factors Leading to Students' Satisfaction in the Higher Learning Institutions

    ERIC Educational Resources Information Center

    Siming, Luo; Niamatullah; Gao, Jianying; Xu, Dan; Shaf, Khurrum

    2015-01-01

    There is an increasing need to understand factors that affect satisfaction of students with learning. This study will explore the relationship between student satisfaction and teacher-student relationship, teacher preparedness, campus support facilities and experiences provided by the institute to the students. Study is a necessary activity that…

  15. Lead exposure in students in Mexico City.

    PubMed

    Alvear Galindo, M G; Carreón García, J; Moreno Altamirano, A; Cuéllar López, J A; Kimura, L Y

    1994-10-01

    The present study was done between 1989 and 1991 and performed on 263 children 7 to 9 years of age who lived in Mexico City. The goal was to determine the association between risk factors entering the body through the respiratory or digestive path and lead concentration in deciduous teeth. Exposure to risk factors was surveyed through a questionnaire; lead was determined by atomic absorption spectrophotometry with a graphite oven and reported in microgram Pb/g tooth. Statistical significance was found for the habit of sucking toys OR 4.98 (IC 95% 1.23-28.67), the use of glazed earthenware utensils for the preparation and serving of food and drinks OR 2.47 (IC 0.80-8.47), and the ingestion of tinned food, particularly juices OR 3.31 (IC 1.03-12.50). No positive results were found for risk factors involving the respiratory path. A possible explanation for these results is a different risk level for each of the two paths of access. PMID:7529159

  16. Antitumor activity of the immunomodulatory lead Cumaside.

    PubMed

    Aminin, D L; Chaykina, E L; Agafonova, I G; Avilov, S A; Kalinin, V I; Stonik, V A

    2010-06-01

    A new immunomodulatory lead Cumaside that is a complex of monosulfated triterpene glycosides from the sea cucumber Cucumaria japonica and cholesterol possesses significantly less cytotoxic activity against sea urchin embryos and Ehrlich carcinoma cells than the corresponding glycosides. Nevertheless Cumaside has an antitumor activity against different forms of experimental mouse Ehrlich carcinoma in vivo both independently and in combination with cytostatics. The highest effect occurs at a treatment once a day for 7 days before the tumor inoculation followed by Cumaside treatment once a day for 7 days. Prophylactic treatment with Cumaside and subsequent therapeutic application of 5-fluorouracil suppressed the tumor growth by 43%. PMID:20227525

  17. An Exploration of Students' Motivation to Lead: An Analysis by Race, Gender, and Student Leadership Behaviors

    ERIC Educational Resources Information Center

    Rosch, David M.; Collier, Daniel; Thompson, Sara E.

    2015-01-01

    This exploratory study examined the motivation to lead of a random sample of 1,338 undergraduate students to determine the degree to which motivation to lead can predict leadership behaviors. Results suggested that students' internal self-identity as a leader positively predicted behavior, while their "social normative" motivation to…

  18. A Network Approach to Preparing Underrepresented Students: The LEAD Model

    ERIC Educational Resources Information Center

    Siegel, David J.

    2008-01-01

    Results are reported from an empirical study of an interorganizational collaboration to prepare underrepresented students for elite postsecondary education and beyond. The LEAD (Leadership Education and Development) Program in Business is an initiative involving twelve U.S. universities, nearly forty multinational corporations, a federal…

  19. Does School Accountability Lead to Improved Student Performance?

    ERIC Educational Resources Information Center

    Hanushek, Eric A.; Raymond, Margaret E.

    2005-01-01

    The leading school reform policy in the United States revolves around strong accountability of schools with consequences for performance. The federal government's involvement through the No Child Left Behind Act of 2001 reinforces the prior movement of many states toward policies based on measured student achievement. Analysis of state achievement…

  20. Students' Educational Activities During Clerkship.

    ERIC Educational Resources Information Center

    O'Sullivan, Patricia S.; And Others

    1997-01-01

    Logs completed by 201 medical students in third-year clerkships at nine community-based hospitals indicated students received 6.5 hours of teaching with an instructor daily, spending 4.9 more hours in clerkship-related learning. Most teaching was by full-time faculty and residents. In half their educational activities, students participated with…

  1. Perspectives on Student Political Activism.

    ERIC Educational Resources Information Center

    Altbach, Philip G.

    1989-01-01

    Presents a historical and international overview of student political movements. Discusses the sporadic nature of student activism, effects of mass media attention and government response, characteristics of activist leaders and participants, and the cultural and educational impact of student protest in Third World and industrialized countries.…

  2. Student Activity Funds: Procedures & Controls.

    ERIC Educational Resources Information Center

    Cuzzetto, Charles E.

    Student activity funds may create educational opportunities for students, but they frequently create problems for business administrators. The first part of this work reviews the types of organizational issues and transactions an organized student group is likely to encounter, including establishing a constitution, participant roles,…

  3. Motivating Students in Fitness Activities

    ERIC Educational Resources Information Center

    Wilkinson, Carol; Hunter, Mike

    2008-01-01

    Physical educators have a responsibility to motivate students to develop personal fitness. This is a critical concept as physical education is the only part of the curriculum capable of meeting the health needs of students regarding physical activity. Current physical educators must promote fitness in ways that motivate students to engage in…

  4. Plasma catecholamine activity in chronic lead poisoning

    SciTech Connect

    deCastro, F.J.

    1990-04-01

    Plasma catecholamines where measured in 15 children with chronic lead poisoning and 15 matched controls by radioimmunassay. The data suggest that plasma catecholamines (norepinephrine and epinphrine) were significantly elevated in chronic lead poisoning. Plasma catecholamine elevation may well be important in the clinical finding of hyperactivity and hypertension associated with chronic lead poisoning.

  5. Hospitality Services. Student Activity Book.

    ERIC Educational Resources Information Center

    Texas Tech Univ., Lubbock. Home Economics Curriculum Center.

    This student activity book contains pencil-and-paper activities for use in a hospitality services course focusing on the food and lodging segments of the hospitality and tourism industry. The activities are organized into 29 chapters on the following topics: hospitality services industry; professional ethics; organization/management structures in…

  6. A Study of Student Activism.

    ERIC Educational Resources Information Center

    Baird, Leonard L.

    Available data on interests, achievement goals, competencies, self-concepts and personalities were used to survey 12, 432 college freshmen at 31 institutions in Spring 1964. The following spring a checklist which combined a Student Activism Scale with items relating to other extracurricular activities was presented to a sample of 5,129 of the…

  7. Coal Activities for Secondary Students.

    ERIC Educational Resources Information Center

    American Coal Foundation, Washington, DC.

    This collection of lesson plans designed for teachers of 4th- through 12th-grade students utilizes an assortment of teaching strategies for topics related to coal and the coal industry. Activities cover the following topics: coal formation; coal identification; "the geologist's dilemma" (a supply and demand activity); geologic time and the…

  8. Student Perceptions of Active Learning

    ERIC Educational Resources Information Center

    Lumpkin, Angela; Achen, Rebecca M.; Dodd, Regan K.

    2015-01-01

    A paradigm shift from lecture-based courses to interactive classes punctuated with engaging, student-centered learning activities has begun to characterize the work of some teachers in higher education. Convinced through the literature of the values of using active learning strategies, we assessed through an action research project in five college…

  9. Empowering Graduate Students to Lead on Interdisciplinary Societal Issues

    NASA Astrophysics Data System (ADS)

    Grubert, E.

    2015-12-01

    Challenging societal problems that cannot be solved by one method or one discipline alone, like epidemic preparedness, mental health, and climate change, demand leadership and the ability to work across disciplines from those with specialized expertise. Teaching leadership at the graduate school level is a challenge that many schools are striving to meet, through mechanisms like project-based courses, leadership skill development workshops, and others. We argue that some of the most valuable but most difficult leadership skills to learn are those that require cultural norms that are fundamentally different from those traditionally encountered in graduate school. These include the ability to make informed decisions based on limited knowledge and resources, the need to make choices in the face of uncertainty, and the recognition that one ultimately bears responsibility for the outcomes. These skills are also among the most important for students planning on nonacademic careers. Acquiring such skills requires a focus on learning-by-doing and a culture of graduate student empowerment. This submission focuses on the experience of students in a student-centered, interdisciplinary, cross-campus leadership program called Emerging Leaders in Science and Society (ELISS), hosted by the American Association for the Advancement of Science (AAAS). ELISS establishes the expectation that students act as leaders, which in itself reframes leadership as an achievable goal. A major finding from two years of experience with ELISS is the critical importance of establishing cultures of trust and empowerment at the graduate level in order to foster development of transferable skills. ELISS graduate students specifically focus on interdisciplinary collaboration (the 13 2015 fellows come from 13 academic disciplines); stakeholder engagement, primarily focused on outreach to both traditional and nontraditional experts in our communities outside of academia; and solution-generating rather

  10. Landsat: Space Activities for Students

    ERIC Educational Resources Information Center

    Marks, Steven K.

    1979-01-01

    An aerospace education activity is described which is suitable for grades 3-12. Students piece together several images from the Landsat satellite to make a mosaic of their state. From the mosaic clear acetate overlay maps can be made relating to such subjects as agriculture, geology, hydrology, or urban planning. (BB)

  11. Coronary Sinus Lead Removal: A Comparison between Active and Passive Fixation Leads

    PubMed Central

    Yildirim, Yalin; Gosau, Nils; Aydin, Ali; Willems, Stephan; Treede, Hendrik; Reichenspurner, Hermann; Hakmi, Samer

    2016-01-01

    Background Implantation of coronary sinus (CS) leads may be a difficult procedure due to different vein anatomies and a possible lead dislodgement. The mode of CS lead fixation has changed and developed in recent years. Objectives We compared the removal procedures of active and passive fixation leads. Methods Between January 2009 and January 2014, 22 patients at our centre underwent CS lead removal, 6 active and 16 passive fixation leads were attempted using simple traction or lead locking devices with or without laser extraction sheaths. Data on procedural variables and success rates were collected and retrospectively analyzed. Results The mean patient age was 67.2 ± 9.8 years, and 90.9% were male. The indication for lead removal was infection in all cases. All active fixation leads were Medtronic® Attain StarFix™ Model 4195 (Medtronic Inc., Minneapolis, MN, USA). The mean time from implantation for the active and passive fixation leads was 9.9 ± 11.7 months (range 1.0–30.1) and 48.7 ± 33.6 months (range 5.7–106.4), respectively (p = 0.012). Only 3 of 6 StarFix leads were successfully removed (50%) compared to 16 of 16 (100%) of the passive fixation CS leads (p = 0.013). No death or complications occurred during the 30-day follow-up. Conclusion According to our experience, removal of the Starfix active fixation CS leads had a higher procedural failure rate compared to passive. PMID:27119368

  12. Spitzer - Hot & Colorful Student Activities

    NASA Astrophysics Data System (ADS)

    McDonald, D.; Rebull, L. M.; DeWolf, C.; Guastella, P.; Johnson, C. H.; Schaefers, J.; Spuck, T.; McDonald, J. G., III; DeWolf, T.; Brock, S.; Boerma, J.; Bemis, G.; Paulsen, K.; Yueh, N.; Peter, A.; Wassmer, W.; Haber, R.; Scaramucci, A.; Butchart, J.; Holcomb, A.; Karns, B.; Kennedy, S.; Siegel, R.; Weiser, S.

    2009-01-01

    In this poster, we present the results of several activities developed for the general science student to explore infrared light. The first activity involved measuring infrared radiation using an updated version of Newton's experiment of splitting white light and finding IR radiation. The second used Leslie's cube to allow students to observe different radiators, while the third used a modern infrared thermometer to measure and identify IR sources in an enclosed box. The last activity involved students making false-color images from narrow-band filter images from data sets from Spitzer Space Telescope, STScI Digitized Sky Survey and other sources. Using computer programs like Adobe Photoshop and free software such as ds9, Spot and Leopard, poster-like images were created by the students. This research is funded by the Spitzer Science Center (SSC) and the National Optical Astronomy Observatory (NOAO). Please see our companion poster, Johnson et al., on the science aspect of this program, and another poster on the educational aspects, Guastella et al.

  13. The Impact of Motivation to Lead on College Students' Cocurricular Involvement

    ERIC Educational Resources Information Center

    Pepper, Robert C.

    2009-01-01

    This exploratory research examined the impact of motivation to lead on college students' cocurricular involvement. The question driving this research was: Is motivation to lead a predictor of cocurricular student involvement? A 52-item questionnaire that included the Motivation to Lead Self-Report Questionnaire (Chan & Drasgow, 2001) was used to…

  14. Lead

    MedlinePlus

    ... Lead Share Facebook Twitter Google+ Pinterest Contact Us Lead Poisoning is Preventable If your home was built before ... of the RRP rule. Read more . Learn about Lead Poisoning Prevention Week . Report Uncertified Contractors and Environmental Violations ...

  15. Catalytically active lead(ii)-imidazolium coordination assemblies with diversified lead(ii) coordination geometries.

    PubMed

    Naga Babu, Chatla; Suresh, Paladugu; Srinivas, Katam; Sathyanarayana, Arruri; Sampath, Natarajan; Prabusankar, Ganesan

    2016-05-10

    Five Pb(ii)-imidazolium carboxylate coordination assemblies with novel structural motifs were derived from the reaction between the corresponding flexible, semi flexible or rigid imidazolium carboxylic acid ligands and lead nitrate. The imidazolium linker present in these molecules likely plays a triple role such as the counter ion to balance the metal charge, the ligand being an integral part of the final product and the catalyst facilitating carbon-carbon bond formation reaction. These lead-imidazolium coordination assemblies exhibit, variable chemical and thermal stabilities, as well as catalytic activity. These newly prepared catalysts are highly active towards benzoin condensation reactions with good functional group tolerance. PMID:27093629

  16. Characterization of nano-lead-doped active carbon and its application in lead-acid battery

    NASA Astrophysics Data System (ADS)

    Hong, Bo; Jiang, Liangxing; Xue, Haitao; Liu, Fangyang; Jia, Ming; Li, Jie; Liu, Yexiang

    2014-12-01

    In this paper, nano-lead-doped active carbon (nano-Pb/AC) composite with low hydrogen evolution current for lead-acid battery was prepared by ultrasonic-absorption and chemical-precipitate method. The nano-Pb/AC composite was characterized by SEM, EDS and TEM. The electrochemical characterizations are performed by linear sweep voltammetry (LSV), electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV) in a three-electrode system. Since intermediate adsorption is the rate-determining step, the hydrogen evolution reaction (HER) is markedly inhibited as the intermediate adsorption impedance of nano-Pb/AC increased. Meanwhile, the working potential of nano-Pb/AC is widened to the whole potential region of Pb negative plate (from -1.36 V to -0.86 V vs. Hg/HgSO4) in lead-acid battery. In addition, nano-Pb can improve the interfacial compatibility between AC and Pb paste, accordingly relieve the symptoms of carbon floatation. Finally, 2.0 V single-cell flooded lead-acid batteries with 1.0 wt.% nano-Pb/AC or 1.0 wt.% AC addition in negative active materials are assembled. The cell performances test results show that the 3 h rate capacity, quick charging performance, high current discharging performance and cycling performance of nano-Pb/AC modified battery are all improved compared with regular lead-acid battery and AC modified lead-acid battery.

  17. Lead

    MedlinePlus

    ... obvious symptoms, it frequently goes unrecognized. CDC’s Childhood Lead Poisoning Prevention Program is committed to the Healthy People ... Lead Levels Information for Parents Tips for preventing lead poisoning About Us Overview of CDC’s Childhood Lead Poisoning ...

  18. Horticulture Therapy Activities for Exceptional Students.

    ERIC Educational Resources Information Center

    Airhart, Douglas L.; And Others

    1988-01-01

    The Tennessee Technological University's Program of Special Education sponsors a "Super Saturday" of enrichment activities for gifted and talented students as well as students with learning disabilities. A session on horticulture was planned and arranged by students in a class on horticultural therapy who designed learning activities of two types:…

  19. A Student Activity That Simulates Evolution

    ERIC Educational Resources Information Center

    Johnson, Nichole L.; Lang-Walker, Rosalyn; Fail, Joseph L., Jr.; Champion, Timothy D.

    2012-01-01

    We describe an activity that uses cards to simulate evolution. The mechanism of the evolutionary pressure in the simulation is clearly indicated for the students. This simulation is useful for allowing student experimentation by varying conditions.

  20. Influence of abatement of lead exposure in Croatia on blood lead and ALAD activity.

    PubMed

    Zorana, Kljaković-Gašpić; Alica, Pizent; Jasna, Jurasović

    2016-01-01

    We evaluated the effect of lead (Pb) abatement measures in Croatia on blood lead (BPb) concentrations, and delta-aminolevulinic acid dehydratase (ALAD) activity in blood, as a sensitive indicator of early Pb effect. Data on BPb and ALAD activity were obtained from 829 Croatian men (19-64 years of age), with no known occupational exposure to metals. Data obtained in 2008-2009, after the ban of leaded gasoline in Croatia in 2006, were compared with similar data collected in 1981 and 1989, when the concentration of Pb in gasoline was 0.6 g/L. Our results showed a highly significant (p < 0.001) decrease in median BPb from 114.5 (range, 46.0-275.0) μg/L in 1981/1989 to 30.3 (range, 3.2-140.8) μg/L in 2008-2009 and an increase in median ALAD activity from 49.8 (range, 24.9-79.4) EU in 1981/1989 to 60.9 (range, 35.8-84.0) EU in 2008-2009. Individual factors influencing BPb values were, in the order of decreasing importance, Pb in ambient air (APb), alcohol consumption, age, and smoking. Increased ALAD activity was significantly associated with the decrease of APb, alcohol consumption, and smoking. These results show that lead abatement measures had a positive impact on both BPb concentrations (73.5% decrease) and the activity of ALAD (22.1% increase) in general population. Our results contribute to growing evidence that ALAD activity may be used as one of the earliest and sensitive diagnostic biomarkers of low-level Pb exposure. PMID:26351197

  1. Leading with Heart: Urban Elementary Principals as Advocates for Students

    ERIC Educational Resources Information Center

    Rodriguez, Mariela A.; Murakami-Ramalho, Elizabeth; Ruff, William G.

    2009-01-01

    Principals in urban settings serve elementary schools often densely populated with highly mobile, ethnically diverse, and economically disadvantaged students. Due to the changing landscape of increasing accountability issues required by the "No Child Left Behind Act (NCLB)" (2001), principals must adjust the mission of the school community to meet…

  2. Guidelines to Student Activity Fund Accounting. Revised.

    ERIC Educational Resources Information Center

    Association of School Business Officials International, Reston, VA.

    This booklet provides guidelines to help school business officials develop sound procedures for keeping proper accounts of and managing the money raised and spent in the course of conducting student activity programs. The booklet notes the roles of the administrators and activity advisers related to management of the student activity fund, then…

  3. Leading the Student Experience: Academic and Professional Services in Partnership Literature Review and Overview of Results. Leading the Student Experience

    ERIC Educational Resources Information Center

    Parkes, Sarah; Young, Julie Blackwell; Cleaver, Elizabeth; Archibald, Kenny

    2014-01-01

    This research project explored how academic and professional personnel work together in new ways to deliver the best possible student experience. The project analysed why certain models of good working practice seemed to work well. The research investigated: how the change management process was perceived and managed by key stakeholders; the role…

  4. A Student Activity on Visual Resolving Power

    ERIC Educational Resources Information Center

    Warren, T. H.; Henriksen, P. N.; Ramsier, R. D.

    2003-01-01

    We present a simple activity in which students measure the resolving power of their eyes. The approach can be used at various levels of sophistication with students having a wide variety of skills and scientific training. We discuss our experiences using this activity with a class of non-science majors as well as with a group of pre-engineering…

  5. Supporting Student Research Group Activities.

    ERIC Educational Resources Information Center

    Lopatin, Dennis E.

    1993-01-01

    This discussion describes methods that foster a healthy Student Research Group (SRG) and permits it to fulfill its responsibility in the development of the student researcher. The model used in the discussion is that of the University of Michigan School of Dentistry SRG. (GLR)

  6. Can nursing students' confidence levels increase with repeated simulation activities?

    PubMed

    Cummings, Cynthia L; Connelly, Linda K

    2016-01-01

    In 2014, nursing faculty conducted a study with undergraduate nursing students on their satisfaction, confidence, and educational practice levels, as it related to simulation activities throughout the curriculum. The study was a voluntary survey conducted on junior and senior year nursing students. It consisted of 30 items based on the Student Satisfaction and Self-Confidence in Learning and the Educational Practices Questionnaire (Jeffries, 2012). Mean averages were obtained for each of the 30 items from both groups and were compared using T scores for unpaired means. The results showed that 8 of the items had a 95% confidence level and when combined the items were significant for p <.001. The items identified were those related to self-confidence and active learning. Based on these findings, it can be assumed that repeated simulation experiences can lead to an increase in student confidence and active learning. PMID:26599594

  7. Explaining Students' Appraisal of Lectures and Student-Activating Teaching: Perceived Context and Student Characteristics

    ERIC Educational Resources Information Center

    Struyven, Katrien; Dochy, Filip; Janssens, Steven

    2012-01-01

    During lectures, some students are continuously focused and attentive, whereas others tend to be bored, jittery, or inattentive. The same might happen when students are given student-activating assignments. Some students simply love one type of instruction, whereas others tend to resent it. Moreover, it is not the context itself, but the context…

  8. Exploring Student Characteristics of Retention That Lead to Graduation in Higher Education Using Data Mining Models

    ERIC Educational Resources Information Center

    Raju, Dheeraj; Schumacker, Randall

    2015-01-01

    The study used earliest available student data from a flagship university in the southeast United States to build data mining models like logistic regression with different variable selection methods, decision trees, and neural networks to explore important student characteristics associated with retention leading to graduation. The decision tree…

  9. Characteristics Leading Teachers to Nominate Secondary Students as Gifted in Spain

    ERIC Educational Resources Information Center

    Hernandez-Torrano, Daniel; Prieto, Maria Dolores; Ferrandiz, Carmen; Bermejo, Rosario; Sainz, Marta

    2013-01-01

    What are the characteristics leading teachers to nominate gifted students in Spain? To answer this question, several demographic (i.e., gender, grade) and psychological (i.e., multiple intelligences, emotional intelligence, intellectual aptitude, and divergent thinking) characteristics of 563 secondary students nominated as gifted by their…

  10. Addressing Lead-Based Paint Hazards During Renovation, Remodeling, and Rehabilitation in Federally Owned and Assisted Housing. Student Manual for Use in HUD-Sponsored Lead-Safe Work Practices Training.

    ERIC Educational Resources Information Center

    Department of Housing and Urban Development, Washington, DC.

    This student manual comprises the United States Environmental Protection Agency's model renovation training course designed for renovation, remodeling, and painting contractors. It provides information regarding the containment, minimization, and cleanup of lead hazards during activities that disturb lead painted surfaces. Introductory material…

  11. Report on First Activations with the Lead Slowing Down Spectrometer

    SciTech Connect

    Warren, Glen A.; Mace, Emily K.; Pratt, Sharon L.; Stave, Sean; Woodring, Mitchell L.

    2011-03-03

    On Feb. 17 and 18 2011, six items were irradiated with neutrons using the Lead Slowing Down Spectrometer. After irradiation, dose measurements and gamma-spectrometry measurements were completed on all of the samples. No contamination was found on the samples, and all but one provided no dose. Gamma-spectroscopy measurements qualitatively agreed with expectations based on the materials, with the exception of silver. We observed activation in the room in general, mostly due to 56Mn and 24Na. Most of the activation was short lived, with half-lives on the scale of hours, except for 198Au which has a half-life of 2.7 d.

  12. Independent Activities for Accelerated Students: Individualized Reading Instruction for Students.

    ERIC Educational Resources Information Center

    Rapides Parish School Board, Alexandria, LAa.

    The teaching guide for use with accelerated elementary school students contains suggestions for independent reading activities, a list of independent reading books for beginning readers, and suggestions for creative activities. Stressed is the value of sharing enthusiasm about books to spur independent reading. Suggestions are given for talking…

  13. Removal of lead from aqueous solutions by activated phosphate.

    PubMed

    Mouflih, M; Aklil, A; Sebti, S

    2005-03-17

    The potential of using activated phosphate as a new adsorbent for the removal of Pb from aqueous solutions was investigated. The kinetic of lead adsorption and the adsorption process were compared for natural phosphate (NP) and activated phosphate (AP). The results indicate that equilibrium was established in about 1h for NP and 3 h for AP. The effect of the pH was examined in the range 2-6. The maximum removal obtained is between two and three for NP and between three and four for AP. The maximum adsorption capacities at 25 degrees C are 155.04 and 115.34 mg/g for AP and NP, respectively. The effect of temperature has been carried out at 25, 35 and 45 degrees C. The data obtained from adsorption isotherms of lead at different temperatures fit to linear form of Langmuir adsorption equation. The thermodynamic parameters such as enthalpy (DeltaH), free energy (DeltaG) and entropy (DeltaS) were calculated. They show that adsorption of lead on NP and AP is an endothermic process more effective at high temperatures. These results show that AP is a good adsorbent for heavy metals from aqueous solutions and could be used as a purifier for water and wastewater. PMID:15752864

  14. Report on Second Activations with the Lead Slowing Down Spectrometer

    SciTech Connect

    Stave, Sean C.; Mace, Emily K.; Pratt, Sharon L.; Warren, Glen A.

    2012-04-27

    Summary On August 18 and 19 2011, five items were irradiated with neutrons using the Lead Slowing Down Spectrometer (LSDS). After irradiation, dose measurements and gamma-spectrometry measurements were completed on all of the samples. No contamination was found on the samples, and all but one provided no dose. Gamma-spectroscopy measurements qualitatively agreed with expectations based on the materials. As during the first activation run, we observed activation in the room in general, mostly due to 56Mn and 24Na. Most of the activation of the samples was short lived, with half-lives on the scale of hours to days, except for 60Co which has a half-life of 5.3 y.

  15. Educational Activity Sites for High School Students

    ERIC Educational Resources Information Center

    Troutner, Joanne

    2005-01-01

    Finding quality Internet resources for high school students is a continuing challenge. Several high-quality web sites are presented for educators and students. These sites offer activities to learn how an art conservator looks at paintings, create a newspaper, research and develop an end product, build geometry and physics skills, explore science…

  16. Student Activism and the War in Vietnam.

    ERIC Educational Resources Information Center

    Geller, Jesse D.; Howard, Gary

    The present study represents an attempt to further delineate the sociological and psychological variables that predispose a student to become an activist of the "new left." A total of 103 students participated in the study, 48 experimental and 55 control subjects. Measures used included a self report, an activism index, a Vietnam opinion Survey,…

  17. Team Building Activities for Young Students

    ERIC Educational Resources Information Center

    Rogers, Kelly

    2004-01-01

    Team building activities are an excellent way to challenge students and teach them the critical communication and problem solving skills that encourage trust, empathy, and ability to work together. They create an atmosphere that enhances the ability to meet fitness and skill goals because students, regardless of skill level, will possess increased…

  18. Student Activities in Meteorology: SAM. Version 2.

    ERIC Educational Resources Information Center

    Meier, Beverly L.; Passarelli, Elisa

    The task of providing hands-on as well as minds-on activities for students in science is one of concern to many scientists and educators. In an effort to inspire student interest in science and technology, scientists from the Forecast Systems Laboratory, a laboratory within the National Oceanic and Atmospheric Administration's (NOAA) Environmental…

  19. High School Students' Participation in Music Activities beyond the School Day

    ERIC Educational Resources Information Center

    Kuntz, Tammy L.

    2011-01-01

    The purpose of this qualitative study was to investigate the music activities that high school band students are involved in and how these activities might lead to lifelong music participation. Specific research questions were the following: (a) In what activities are high school band students involved? (b) What are high school band directors…

  20. Green synthesis, spectroscopic investigation and photocatalytic activity of lead nanoparticles.

    PubMed

    Elango, Ganesh; Roopan, Selvaraj Mohana

    2015-03-15

    Most of researcher focused their research towards synthesize of nanoparticles by the method of applied chemical method which was one of the costliest method. We have focused cheapest and simplest method for the synthesizing of lead nanoparticles (Pb-NPs) using cocos nucifera L extract. The methanolic extract of cocos nucifera L was efficiently used as a reducing agent for synthesizing Pb-NPs. On treatment of lead acetate with cocos nucifera coir extracts, stable Pb-NPs were formed. The synthesized Pb-NPs were further confirmed by UV-visible spectroscopy, X-ray diffraction (XRD), Transmission electron microscope (TEM) and Energy Dispersive (EDAX) analysis. The secondary metabolites present in methanolic extract which can mainly act as a reducing and capping agents for the formation of Pb-NPs were identified by GC-MS. Anti-microbial activity for Pb-NPs against four pathogenic strain's such as Staphylococcus aureus, Escheria coli, Staphylococcus epidermis and Bacillus subtilis. Result states that Pb-NPs size was 47 nm and also shows good activity against S. aureus. Further we report on photocatalytic absorption of malachite green dye processed in short UV wavelength at 254 nm. UV spectral analysis showed peak absorbance at 613 nm with special reference to the excitation of surfaces plasmon vibration by Pb-NPs. PMID:25574657

  1. Green synthesis, spectroscopic investigation and photocatalytic activity of lead nanoparticles

    NASA Astrophysics Data System (ADS)

    Elango, Ganesh; Roopan, Selvaraj Mohana

    2015-03-01

    Most of researcher focused their research towards synthesize of nanoparticles by the method of applied chemical method which was one of the costliest method. We have focused cheapest and simplest method for the synthesizing of lead nanoparticles (Pb-NPs) using cocos nucifera L extract. The methanolic extract of cocos nucifera L was efficiently used as a reducing agent for synthesizing Pb-NPs. On treatment of lead acetate with cocos nucifera coir extracts, stable Pb-NPs were formed. The synthesized Pb-NPs were further confirmed by UV-visible spectroscopy, X-ray diffraction (XRD), Transmission electron microscope (TEM) and Energy Dispersive (EDAX) analysis. The secondary metabolites present in methanolic extract which can mainly act as a reducing and capping agents for the formation of Pb-NPs were identified by GC-MS. Anti-microbial activity for Pb-NPs against four pathogenic strain's such as Staphylococcus aureus, Escheria coli, Staphylococcus epidermis and Bacillus subtilis. Result states that Pb-NPs size was 47 nm and also shows good activity against S. aureus. Further we report on photocatalytic absorption of malachite green dye processed in short UV wavelength at 254 nm. UV spectral analysis showed peak absorbance at 613 nm with special reference to the excitation of surfaces plasmon vibration by Pb-NPs.

  2. Promoting Health-Related Fitness during Warm-Up Activities for Secondary Students

    ERIC Educational Resources Information Center

    Johnson, Ingrid

    2008-01-01

    It is common to begin a physical education class by having students run laps. Many teachers find that doing the same running warm-up day after day leads to boredom and a lack of interest in their students. This article provides teachers with developmentally appropriate warm-up activities that will not only motivate students, but also keep them…

  3. Sports Medicine. Instructor's Guide, Student's Manual, Student Learning Activities.

    ERIC Educational Resources Information Center

    Fair, Helena J.

    The instructor's guide, the first of three documents in this package, is for a course designed for students investigating the activities within the sports medicine department or considering any of the areas of kinesiology as a career. The material is designed for individualized study and is competency based with educational outcomes stated for…

  4. Successful Strategies for Promoting Self-Advocacy among Students with LD: The LEAD Group.

    ERIC Educational Resources Information Center

    Pocock, Al; Lambros, Stan; Karvonen, Meagan; Test, David W.; Algozzine, Bob; Wood, Wendy; Martin, James E.

    2002-01-01

    This article describes methods used by one school district to promote self-advocacy skills for students with learning disabilities. Through multicomponent group activities, students learned about their strengths and disabilities and how to advocate for educational needs and rights. Advocacy skills were applied to leadership roles, mentoring, and…

  5. How Students Are Leading Us: Youth Organizing and the Fight for Public Education in Philadelphia

    ERIC Educational Resources Information Center

    Conner, Jerusha; Rosen, Sonia

    2013-01-01

    Philadelphia has a rich history of high school student activism, stretching back to 1967, when 3,500 Philadelphia students walked out of their schools, marched to the Board of Education, and demanded the addition of black history courses taught by black teachers, the removal of police from high schools, and an increase in the hiring of black…

  6. Teamwork Benefits in Tertiary Education: Student Perceptions That Lead to Best Practice Assessment Design

    ERIC Educational Resources Information Center

    Volkov, Arabella; Volkov, Michael

    2015-01-01

    Purpose: The purpose of this paper is to contribute to the understanding of the development of students' skills in the context of team-based learning. Academics have heeded the call to incorporate team learning activities into the curricula, yet little is known of student perception of teamwork and whether they view it as beneficial to them and…

  7. Metabolic activation of carcinogenic ethylbenzene leads to oxidative DNA damage.

    PubMed

    Midorikawa, Kaoru; Uchida, Takafumi; Okamoto, Yoshinori; Toda, Chitose; Sakai, Yoshie; Ueda, Koji; Hiraku, Yusuke; Murata, Mariko; Kawanishi, Shosuke; Kojima, Nakao

    2004-12-01

    Ethylbenzene is carcinogenic to rats and mice, while it has no mutagenic activity. We have investigated whether ethylbenzene undergoes metabolic activation, leading to DNA damage. Ethylbenzene was metabolized to 1-phenylethanol, acetophenone, 2-ethylphenol and 4-ethylphenol by rat liver microsomes. Furthermore, 2-ethylphenol and 4-ethylphenol were metabolically transformed to ring-dihydroxylated metabolites such as ethylhydroquinone and 4-ethylcatechol, respectively. Experiment with 32P-labeled DNA fragment revealed that both ethylhydroquinone and 4-ethylcatechol caused DNA damage in the presence of Cu(II). These dihydroxylated compounds also induced the formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine in calf thymus DNA in the presence of Cu(II). Catalase, methional and Cu(I)-specific chelator, bathocuproine, significantly (P<0.05) inhibited oxidative DNA damage, whereas free hydroxyl radical scavenger and superoxide dismutase did not. These results suggest that Cu(I) and H2O2 produced via oxidation of ethylhydroquinone and 4-ethylcatechol are involved in oxidative DNA damage. Addition of an endogenous reductant NADH dramatically enhanced 4-ethylcatechol-induced oxidative DNA damage, whereas ethylhydroquinone-induced DNA damage was slightly enhanced. Enhancing effect of NADH on oxidative DNA damage by 4-ethylcatechol may be explained by assuming that reactive species are generated from the redox cycle. In conclusion, these active dihydroxylated metabolites would be involved in the mechanism of carcinogenesis by ethylbenzene. PMID:15560893

  8. Combination of didactic lectures and review sessions in endocrinology leads to improvement in student performance as measured by assessments.

    PubMed

    Qureshi, Ayisha; Cozine, Cassy; Rizvi, Farwa

    2013-03-01

    There can be no single best way of learning, and each teaching mode has its own merits and demerits. Didactic lectures in and of themselves are insufficient, whereas a problem-based tutorial alone can be as ineffective. This study was conducted to determine if a problem-based review after didactic lectures would lead to better student performance. To compare performance, the same student group was taught three units of endocrinology (growth hormone, thyroid hormone, and diabetes). Students were divided into the following three groups: diabetes didactic lectures only, growth hormone didactic lectures plus review, and thyroid hormone didactic lectures plus review. All three topics were covered in the didactic lectures, but only growth hormone and thyroid hormone topics were covered in the review session. At the end of the course, all students were given formative assessments in the form of multiple-choice questions. A highly significant increase (P < 0.000) in the percentage of correct responses on the questions covering growth hormone (mean: 0.838, SD: 0.158) and thyroid hormone (mean: 0.686, SD: 0.232) compared with diabetes (mean: 0.478, SD: 0.259) was observed. In conclusion, this study provides further evidence that the combination of didactic lectures and an active review session leads to an improvement in student performance. PMID:23471255

  9. Advanced Placement Economics. Macroeconomics: Student Activities.

    ERIC Educational Resources Information Center

    Morton, John S.

    This book is designed to help advanced placement students better understand macroeconomic concepts through various activities. The book contains 6 units with 64 activities, sample multiple-choice questions, sample short essay questions, and sample long essay questions. The units are entitled: (1) "Basic Economic Concepts"; (2) "Measuring Economic…

  10. Advanced Placement Economics. Microeconomics: Student Activities.

    ERIC Educational Resources Information Center

    Morton, John S.

    This book is designed to help advanced placement students better understand microeconomic concepts through various activities. The book contains 5 units with 73 activities, sample multiple-choice questions, sample short essay questions, and sample long essay questions. The units are entitled: (1) "The Basic Economic Problem"; (2) "The Nature and…

  11. Physical Activity among Community College Students

    ERIC Educational Resources Information Center

    Young, Sarah J.; Sturts, Jill R.; Ross, Craig M.

    2015-01-01

    This exploratory study provides insight into the perceived physical activity levels of students attending a Midwestern 2-year community college. Over 60% of respondents were classified as overweight or obese based on a BMI measurement. The majority of respondents were not participating regularly in physical activity to gain any health benefits,…

  12. Practical Activities in Astronomy for Nonscience Students.

    ERIC Educational Resources Information Center

    Bisard, Walter J.

    1985-01-01

    Describes science activities which have been successful with nonscience majors. Each activity requires students to make observations, record the data gathered, interpret data, and prepare a written report. Subject areas include motion of stars, sunspots, lunar orbits, sunset points, meteor showers, and sun shadows. (JN)

  13. Helping Students Become Active and Smart!

    ERIC Educational Resources Information Center

    Holt, Rhonda

    2005-01-01

    With the recently released Position Statement, "Physical Activity for Children Guidelines" (NASPE, 2004), the time is ideal for physical educators to look for ways to encourage students to be active outside the classroom. The first guideline recommends "children accumulate at least 60 minutes, and up to several hours of age-appropriate physical…

  14. Health Activities for Primary School Students.

    ERIC Educational Resources Information Center

    Peace Corps, Washington, DC. Information Collection and Exchange Div.

    This manual targets new and second-year Peace Corps volunteers, presenting health lessons and activities for primary school students in Thailand. Each section of the manual outlines basic technical information about the topic, contains several detailed lesson plans, and lists quick activities that can be carried out at schools. Songs and recipes…

  15. Activities to Develop Your Students' Motor Skills.

    ERIC Educational Resources Information Center

    Eastman, Mary Kay; Safran, Joan S.

    1986-01-01

    Instructions and illustrations support this discussion of learning activities designed to remediate deficiences and build skills in balance and/or motor skills for mildly handicapped students who may not have access to physical therapy or adaptive physical education. Appropriate for both regular and special classes, activities include arm…

  16. Quinolone Amides as Antitrypanosomal Lead Compounds with In Vivo Activity.

    PubMed

    Hiltensperger, Georg; Hecht, Nina; Kaiser, Marcel; Rybak, Jens-Christoph; Hoerst, Alexander; Dannenbauer, Nicole; Müller-Buschbaum, Klaus; Bruhn, Heike; Esch, Harald; Lehmann, Leane; Meinel, Lorenz; Holzgrabe, Ulrike

    2016-08-01

    Human African trypanosomiasis (HAT) is a major tropical disease for which few drugs for treatment are available, driving the need for novel active compounds. Recently, morpholino-substituted benzyl amides of the fluoroquinolone-type antibiotics were identified to be compounds highly active against Trypanosoma brucei brucei Since the lead compound GHQ168 was challenged by poor water solubility in previous trials, the aim of this study was to introduce structural variations to GHQ168 as well as to formulate GHQ168 with the ultimate goal to increase its aqueous solubility while maintaining its in vitro antitrypanosomal activity. The pharmacokinetic parameters of spray-dried GHQ168 and the newly synthesized compounds GHQ242 and GHQ243 in mice were characterized by elimination half-lives ranging from 1.5 to 3.5 h after intraperitoneal administration (4 mice/compound), moderate to strong human serum albumin binding for GHQ168 (80%) and GHQ243 (45%), and very high human serum albumin binding (>99%) for GHQ242. For the lead compound, GHQ168, the apparent clearance was 112 ml/h and the apparent volume of distribution was 14 liters/kg of body weight (BW). Mice infected with T. b. rhodesiense (STIB900) were treated in a stringent study scheme (2 daily applications between days 3 and 6 postinfection). Exposure to spray-dried GHQ168 in contrast to the control treatment resulted in mean survival durations of 17 versus 9 days, respectively, a difference that was statistically significant. Results that were statistically insignificantly different were obtained between the control and the GHQ242 and GHQ243 treatments. Therefore, GHQ168 was further profiled in an early-treatment scheme (2 daily applications at days 1 to 4 postinfection), and the results were compared with those obtained with a control treatment. The result was statistically significant mean survival times exceeding 32 days (end of the observation period) versus 7 days for the GHQ168 and control treatments

  17. Beta-adrenergic receptor density and adenylate cyclase activity in lead-exposed rat brain after cessation of lead exposure.

    PubMed

    Chang, Huoy-Rou; Tsao, Der-An; Yu, Hsin-Su; Ho, Chi-Kung

    2005-01-01

    To understanding the reversible or irreversible harm to the beta-adrenergic system in the brain of lead-exposed rats, this study sets up an animal model to estimate the change in the sympathetic nervous system of brain after lead exposure was withdrawn. We address the following topics in this study: (a) the relationship between withdrawal time of lead exposure and brain beta-adrenergic receptor, blood lead level, and brain lead level in lead-exposed rats after lead exposure was stopped; and (b) the relationship between lead level and beta-adrenergic receptor and cyclic AMP (c-AMP) in brain. Wistar rats were chronically fed with 2% lead acetate and water for 2 months. Radioligand binding was assayed by a method that fulfilled strict criteria of beta-adrenergic receptor using the ligand [125I]iodocyanopindolol. The levels of lead were determined by electrothermal atomic absorption spectrometry. The c-AMP level was determined by radioimmunoassay. The results showed a close relationship between decreasing lead levels and increasing numbers of brain beta-adrenergic receptors and brain adenylate cyclase activity after lead exposure was withdrawn. The effect of lead exposure on the beta-adrenergic system of the brain is a partly reversible condition. PMID:15502967

  18. The Effect of Project-Based Activities on Intermediate EFL Students' Reading Comprehension Ability

    ERIC Educational Resources Information Center

    Shiraz, Mona Poorverdi; Larsari, Ebrahim Ezati

    2014-01-01

    The present study investigates the relationship between the use of Project-based activities and intermediate EFL students' reading comprehension. The study addresses the questions of whether students' reading comprehension differs after implementing Project-based activities, and whether different projects lead to different degrees of reading…

  19. Lead in Hair and in Red Wine by Potentiometric Stripping Analysis: The University Students' Design.

    ERIC Educational Resources Information Center

    Josephsen, Jens

    1985-01-01

    A new program for training upper secondary school chemistry teachers (SE 537 693) depends heavily on student project work. A project in which lead in hair and in red wine was examined by potentiometric stripping analysis is described and evaluated. (JN)

  20. Technology in the Classroom: Creating Videos Can Lead Students to Many Academic Benefits

    ERIC Educational Resources Information Center

    Morgan, Hani

    2013-01-01

    Assigning students projects involving video production can lead to many positive academic outcomes, and today more opportunities exist for educators to incorporate such video-oriented projects into their classroom practice. Video-making technology is more affordable, more user-friendly, and more powerful than ever before. This article discusses…

  1. 40 CFR 745.233 - Lead-based paint activities requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) TOXIC SUBSTANCES CONTROL ACT LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES Lead-Based Paint Activities § 745.233 Lead-based paint activities requirements. Lead-based paint... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Lead-based paint...

  2. 40 CFR 745.233 - Lead-based paint activities requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) TOXIC SUBSTANCES CONTROL ACT LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES Lead-Based Paint Activities § 745.233 Lead-based paint activities requirements. Lead-based paint... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Lead-based paint...

  3. 40 CFR 745.233 - Lead-based paint activities requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) TOXIC SUBSTANCES CONTROL ACT LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES Lead-Based Paint Activities § 745.233 Lead-based paint activities requirements. Lead-based paint... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Lead-based paint...

  4. 40 CFR 745.233 - Lead-based paint activities requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) TOXIC SUBSTANCES CONTROL ACT LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES Lead-Based Paint Activities § 745.233 Lead-based paint activities requirements. Lead-based paint... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Lead-based paint...

  5. Student-Student Online Coaching: Conceptualizing an Emerging Learning Activity

    ERIC Educational Resources Information Center

    Hrastinski, Stefan; Stenbom, Stefan

    2013-01-01

    The aim of this paper is to describe student-student online coaching, defined as "an online service where a student gets support on a specific subject matter from a more experienced student". Student-student online coaching emphasizes learning a subject matter by giving a student the opportunity to get coached by a coach, i.e. a more experienced…

  6. The impact of low technology lead hazard reduction activities among children with mildly elevated blood lead levels

    SciTech Connect

    Aschengrau, A.; Hardy, S.; Mackey, P.; Pultinas, D.

    1998-10-01

    This prospective environmental intervention study was conducted to determine the impact of low-technology lead hazard reduction activities among children with mildly elevated blood lead levels. Children whose homes had severe lead hazards were automatically assigned to the intervention group. Children whose homes had lesser hazards were randomly assigned to the intervention group or comparison group. The one-time intervention focused mainly on cleaning and repainting window areas and educating caregivers to maintain effective housekeeping techniques. Changes in blood lead and dust lead loading levels were observed following the interventions. Analysis of covariance was used to adjust comparisons of postintervention levels for preintervention levels and other variables. The lead hazard reduction activities were associated with a modest decline in blood lead levels among children with severe hazards. The magnitude of the decline depended on the confounder that was controlled; the majority ranged from {minus}1.1 to {minus}1.6 {micro}g/dL. A moderate reduction in window well dust lead loading levels was also observed. While low-technology lead hazard reduction measures appeared to be an effective secondary prevention strategy among children with severe household lead hazards, larger studies are needed to confirm these results.

  7. Astronomy Student Activities Using Stellarium Software

    NASA Astrophysics Data System (ADS)

    Benge, Raymond D.; Tuttle, S. R.

    2012-01-01

    Planetarium programs can be used to provide a valuable learning experience for introductory astronomy students. Educational activities can be designed to utilize the capabilities of the software to display the sky, coordinates, motions in the sky, etc., in order to learn basic astronomical concepts. Most of the major textbook publishers have an option of bundling planetarium software and even laboratory activities using such software with textbooks. However, commercial planetarium software often is updated on a different schedule from the textbook revision and new edition schedule. The software updates also sometimes occur out of sync with college textbook adoption deadlines. Changes in software and activity curriculum often translate into increases costs for students and the college. To provide stability to the process, faculty at Tarrant County College have developed a set of laboratory exercises, entitled Distant Nature, using free open source Stellarium software. Stellarium is a simple, yet powerful, program that is available in formats that run on a variety of operating systems (Windows, Apple, linux). A web site was developed for the Distant Nature activities having a set version of Stellarium that students can download and install on their own computers. Also on the web site, students can access the instructions and worksheets associated with the various Stellarium based activities. A variety of activities are available to support two semesters of introductory astronomy. The Distant Nature web site has been used for one year with Tarrant County College astronomy students and is now available for use by other institutions. The Distant Nature web site is http://www.stuttle1.com/DN_Astro/index.html .

  8. Student Active Learning Methods in Physical Chemistry

    NASA Astrophysics Data System (ADS)

    Hinde, Robert J.; Kovac, Jeffrey

    2001-01-01

    We describe two strategies for implementing active learning in physical chemistry. One involves supplementing a traditional lecture course with heavily computer-based active-learning exercises carried out by cooperative groups in a department computer lab. The other uses cooperative learning almost exclusively, supplemented by occasional mini-lectures. Both approaches seemed to result in better student learning and a more positive attitude toward the subject. On the basis of our respective experiences using active learning techniques, we discuss some of the strengths of these techniques and some of the challenges we encountered using the active-learning approach in teaching physical chemistry.

  9. Quilts of Alaska--Student Activities.

    ERIC Educational Resources Information Center

    Alaska State Museum, Juneau.

    This student activities booklet, "Quilts of Alaska," contains historical and educational information on quilts. It is colorfully illustrated with examples of different types of quilts. The booklet describes album or signature quilts, which from 1840 to the 1890s, were a U.S. fad, such as were autograph albums. As the name suggests, these quilts…

  10. Student Activity Funds: Procedures and Controls.

    ERIC Educational Resources Information Center

    Cuzzetto, Charles E.

    2000-01-01

    An effective internal-control system can help school business administrators meet the challenges of accounting for student activity funds. Such a system should include appropriate policies and procedures, identification of key control points, self-assessments, audit trails, and internal and external audits. (MLH)

  11. Embedding Research Activities to Enhance Student Learning

    ERIC Educational Resources Information Center

    Webster, Cynthia M.; Kenney, Jacqueline

    2011-01-01

    Purpose: The purpose of this paper's novel, research-oriented approach is to embed research-based activities in a core second-year course of a university business degree program to support and develop student research capabilities. Design/methodology/approach: The design draws on Boud and Prosser's work to foster participation in a…

  12. The Characteristics of a Student Activities Director.

    ERIC Educational Resources Information Center

    Hughs, Teena

    Twenty-four characteristics of effective leaders are described as an aid in helping others become effective student activities directors. It is stated that leaders are made, not born; leadership must be learned from experience, not from a textbook; and one must build on successes and learn from mistakes. Among the characteristics of effective…

  13. Farkle Fundamentals and Fun. Activities for Students

    ERIC Educational Resources Information Center

    Hooley, Donald E.

    2014-01-01

    The dice game Farkle provides an excellent basis for four activities that reinforce probability and expected value concepts for students in an introductory statistics class. These concepts appear in the increasingly popular AP statistics course (Peck 2011) and are used in analyzing ethical issues from insurance and gambling (COMAP 2009; Woodward…

  14. Journey to China: Activities for Elementary Students.

    ERIC Educational Resources Information Center

    Stanford Univ., CA. Stanford Program on International and Cross Cultural Education.

    Ten lessons designed to introduce elementary students to China are featured in this document. The lessons are aimed at second through fourth grade, but they also include follow-up activities for kindergarten through sixth grade and are easily adapted to a given grade level. The lessons also are designed to incorporate elements and skills…

  15. Incorporating Student Activities into Climate Change Education

    NASA Astrophysics Data System (ADS)

    Steele, H.; Kelly, K.; Klein, D.; Cadavid, A. C.

    2013-12-01

    atmospheric circulation with applications of the Lorenz model, explored the land-sea breeze problem with the Dynamics and Thermodynamics Circulation Model (DTDM), and developed simple radiative transfer models. Class projects explored the effects of varying the content of CO2 and CH4 in the atmosphere, as well as the properties of paleoclimates in atmospheric simulations using EdGCM. Initial assessment of student knowledge, attitudes, and behaviors associated with these activities, particularly about climate change, was measured. Pre- and post-course surveys provided student perspectives about the courses and their learning about remote sensing and climate change concepts. Student performance on the tutorials and course projects evaluated students' ability to learn and apply their knowledge about climate change and skills with remote sensing to assigned problems or proposed projects of their choice. Survey and performance data illustrated that the exercises were successful in meeting their intended learning objectives as well as opportunities for further refinement and expansion.

  16. CONTRIBUTION OF CHLIDREN'S ACTIVITIES TO LEAD CONTAMINATION OF FOOD

    EPA Science Inventory

    This study evaluates the relationship of children's hygiene habits and food handling behaviors on lead levels on hands and handled foods for toddlers living in lead contaminated homes. Forty eight inner city toddlers who had previously been identified as having elevated blood le...

  17. Student Attitudes and Recommendations on Active Learning: A Student-Led Survey Gauging Course Effectiveness.

    ERIC Educational Resources Information Center

    Marbach-Ad, Gili; Seal, October; Sokolove, Phillip

    2001-01-01

    Describes an active learning approach used in an introductory biology class and evaluates the project with student surveys. Presents students' answers to survey questions. (Contains 16 references.) (YDS)

  18. Toolbox of activities to support students in a physics gateway course

    NASA Astrophysics Data System (ADS)

    Kalman, Calvin S.; Rohar, Shelley

    2010-07-01

    This paper presents a set of activities, which scaffolds students to succeed in the standard Physics gateway course. The set of instructional activities that were designed included four distinct components: reflective writing, collaborative groups, critiques, and an essay question on the examination. Each activity was designed to lead into and connect with the other activities, with the intention that students would establish links between different parts of the course. Implementation was studied at three postsecondary institutions. The results demonstrate that the combination of instructional activities were successful in scaffolding the students and getting them to view the course in a holistic manner.

  19. Uptake of Optional Activities Leads to Improved Performance in a Biomedical Sciences Class

    ERIC Educational Resources Information Center

    Verkade, Heather; Lim, Saw Hoon

    2015-01-01

    Optional (non-assessed) learning activities are a learning tool that may help students achieve their desired grade, or help students with lower levels of previous experience in the topic. This study examines the implementation of, and outcomes from, two optional activities, one online and one paper-based. The activities complemented the lectures…

  20. Number Wonders: 171 Activities to Meet Math Standards & Inspire Students

    ERIC Educational Resources Information Center

    Kuhns, Catherine Jones

    2006-01-01

    In this book, author Catherine Jones Kuhns introduces student- and teacher-friendly math activities designed to get students thinking like mathematicians and loving mathematics, while addressing content standards through grade 2. She also shows how to make math fun for students, get children actively engaged in learning, create a student-centered…

  1. Assessing High School Student Learning on Science Outreach Lab Activities

    ERIC Educational Resources Information Center

    Thomas, Courtney L.

    2012-01-01

    The effect of hands-on laboratory activities on secondary student learning was examined. Assessment was conducted over a two-year period, with 262 students participating the first year and 264 students the second year. Students took a prequiz, performed a laboratory activity (gas chromatography of alcohols, or photosynthesis and respiration), and…

  2. Evaluation of Student Activities through Surveys of Harper Students and Employees. Volume XXI, No. 6.

    ERIC Educational Resources Information Center

    Lucas, John A.; And Others

    As part of the program review process at William Rainey Harper College (WRHC) in Palatine, Illinois, surveys were administered to three groups of students and to all WRHC employees to provide a partial evaluation of student activities. The three samples of students surveyed included 100 Caucasian students, 100 minority students, and 100 disabled…

  3. American Student Activism: The Post-Sixties Transformation.

    ERIC Educational Resources Information Center

    Altbach, Philip G.; Cohen, Robert

    1990-01-01

    The trends in college student attitudes and activism in the 1980s are explored, focusing on patterns of attitudes, issues that motivate students, and the campuses on which activism appears to flourish. (MSE)

  4. Toolbox of Activities to Support Students in a Physics Gateway Course

    ERIC Educational Resources Information Center

    Kalman, Calvin S.; Rohar, Shelley

    2010-01-01

    This paper presents a set of activities, which scaffolds students to succeed in the standard Physics gateway course. The set of instructional activities that were designed included four distinct components: reflective writing, collaborative groups, critiques, and an essay question on the examination. Each activity was designed to lead into and…

  5. Academic provenance: Investigation of pathways that lead students into the geosciences

    NASA Astrophysics Data System (ADS)

    Houlton, Heather R.

    Pathways that lead students into the geosciences as a college major have not been fully explored in the current literature, despite the recent studies on the "geoscience pipeline model." Anecdotal evidence suggests low quality geoscience curriculum in K-12 education, lack of visibility of the discipline and lack of knowledge about geoscience careers contribute to low geoscience enrollments at universities. This study investigated the reasons why college students decided to major in the geosciences. Students' interests, experiences, motivations and desired future careers were examined to develop a pathway model. In addition, self-efficacy was used to inform pathway analyses, as it is an influential factor in academic major and career choice. These results and interpretations have strong implications for recruitment and retention in academia and industry. A semi-structured interview protocol was developed, which was informed by John Flanagan's critical incident theory. The responses to this interview were used to identify common experiences that diverse students shared for reasons they became geoscience majors. Researchers used self-efficacy theory by Alfred Bandura to assess students' pathways. Seventeen undergraduate geoscience majors from two U.S. Midwest research universities were sampled for cross-comparison and analysis. Qualitative analyses led to the development of six categorical steps for the geoscience pathway. The six pathway steps are: innate attributes/interest sources, pre-college critical incidents, college critical incidents, current/near future goals, expected career attributes and desired future careers. Although, how students traversed through each step was unique for individuals, similar patterns were identified between different populations in our participants: Natives, Immigrants and Refugees. In addition, critical incidents were found to act on behavior in two different ways: to support and confirm decision-making behavior (supportive critical

  6. Differential MSC activation leads to distinct mononuclear leukocyte binding mechanisms

    NASA Astrophysics Data System (ADS)

    Kota, Daniel J.; Dicarlo, Bryan; Hetz, Robert A.; Smith, Philippa; Cox, Charles S.; Olson, Scott D.

    2014-04-01

    Advances in the field of Multipotent Mesenchymal Stromal cell (MSC) biology have demonstrated that MSCs can improve disease outcome when `activated' to exert immunomodulatory effects. However, the precise mechanisms modulating MSC-immune cells interactions remain largely elusive. In here, we activated MSC based on a recent polarization paradigm, in which MSCs can be polarized towards a pro- or anti-inflammatory phenotype depending on the Toll-like receptor stimulated, to dissect the mechanisms through which MSCs physically interact with and modulate leukocytes in this context. Our data show that MSCs activated through the Toll-like receptor (TLR) 4 pathway increased VCAM-1 and ICAM-1 dependent binding of leukocytes. On the other hand, TLR3 stimulation strongly increases leukocytes affinity to MSC comparatively, through the formation of cable-like hyaluronic acid structures. In addition, TLR4 activation elicited secretion of pro-inflammatory mediators by MSCs, whereas TLR3-activated MSCs displayed a milder pro-inflammatory phenotype, similar to inactivated MSCs. However, the differently activated MSCs maintained their ability to suppress leukocyte activation at similar levels in our in vitro model, and this immunomodulatory property was shown here to be partially mediated by prostaglandin. These results reinforce the concept that alternate activation profiles control MSC responses and may impact the therapeutic use of MSCs.

  7. HUD`s lead-based paint activities

    SciTech Connect

    Morony, R.

    1994-12-31

    Title X of Public Law 102-550 is a major piece of legislation for the Department having to do with lead-based paint. It changes the way the Department is going to be doing all of its work with lead-based paint in all areas except public housing. It is a mandate from Congress for a great deal of change. It is going to cause revisions in the regulations. Title X authorizes a grant program to State and local governments for the abatement of lead-based paint in low income, privately owned housing. This is an area that has not gotten attention from the Federal government before. The first series of grants have been awarded, some $46 million, to six States, three cities, and one county. The grantees have been selected for $91 million that will go to 19 winners. They received 63 applications, again from State and local governments, again for privately owned housing. There is a third grant series in this fiscal year. The applications for the $142 million are due July 5, 1994. Again, HUD is looking at privately owned housing. This is not housing that is, in most cases, federally assisted in any way.

  8. Student Perceptions of Social Justice and Social Justice Activities

    ERIC Educational Resources Information Center

    Torres-Harding, Susan R.; Steele, Cheronda; Schulz, Erica; Taha, Farah; Pico, Chantal

    2014-01-01

    Encouraging students to engage in activities that actively seek to promote social justice is a goal of many educators. This study analyzed college student perceptions around social justice and related activities in a medium-sized, urban university in the United States. Students' open-ended responses to questions assessing their perceptions of…

  9. Hands-On Activities and Their Influence on Students' Interest

    ERIC Educational Resources Information Center

    Holstermann, Nina; Grube, Dietmar; Bogeholz, Susanne

    2010-01-01

    This study investigates the influence of hands-on activities on students' interest. We researched whether students with experience in specific hands-on activities show higher interest in these activities than students without experience. Furthermore, the relationship between the quality of the hands-on experience and interest in the respective…

  10. Bacterial recognition pathways that lead to inflammasome activation

    PubMed Central

    Storek, Kelly M; Monack, Denise M

    2015-01-01

    Inflammasomes are multi-protein signaling platforms that upon activation trigger the maturation of the pro-inflammatory cytokines, interleukin-1β (IL-1β) and IL-18, and cell death. Inflammasome sensors detect microbial and host-derived molecules. Here, we review the mechanisms of inflammasome activation triggered by bacterial infection, primarily focusing on two model intracellular bacterial pathogens, Francisella novicida and Salmonella typhimurium. We discuss the complex relationship between bacterial recognition through direct and indirect detection by inflammasome sensors. We highlight regulation mechanisms that potentiate or limit inflammasome activation. We discuss the importance of caspase-1 and caspase-11 in host defense, and we examine the downstream consequences of inflammasome activation within the context of bacterial infections. PMID:25879288

  11. Invasive pneumococcal disease leads to activation and hyperreactivity of platelets.

    PubMed

    Tunjungputri, Rahajeng N; de Jonge, Marien I; de Greeff, Astrid; van Selm, Saskia; Buys, Herma; Harders-Westerveen, Jose F; Stockhofe-Zurwieden, Norbert; Urbanus, Rolf T; de Groot, Phillip G; Smith, Hilde E; van der Ven, Andre J; de Mast, Quirijn

    2016-08-01

    Using a novel porcine model of intravenous Streptococcus pneumoniae infection, we showed that invasive pneumococcal infections induce marked platelet activation and hyperreactivity. This may contribute to the vascular complications seen in pneumococcal infection. PMID:27322088

  12. Endoplasmic reticulum stress activates transglutaminase 2 leading to protein aggregation

    PubMed Central

    LEE, JIN-HAENG; JEONG, JAEHO; JEONG, EUI MAN; CHO, SUNG-YUP; KANG, JEONG WOOK; LIM, JISUN; HEO, JINBEOM; KANG, HYUNSOOK; KIM, IN-GYU; SHIN, DONG-MYUNG

    2014-01-01

    Aberrant activation of transglutaminase 2 (TGase2) contributes to a variety of protein conformational disorders such as neurodegenerative diseases and age-related cataracts. The accumulation of improperly folded proteins in the endoplasmic reticulum (ER) triggers the unfolded protein response (UPR), which promotes either repair or degradation of the damaged proteins. Inadequate UPR results in protein aggregation that may contribute to the development of age-related degenerative diseases. TGase2 is a calcium-dependent enzyme that irreversibly modifies proteins by forming cross-linked protein aggregates. Intracellular TGase2 is activated by oxidative stress which generates large quantities of unfolded proteins. However, the relationship between TGase2 activity and UPR has not yet been established. In the present study, we demonstrated that ER stress activated TGase2 in various cell types. TGase2 activation was dependent on the ER stress-induced increase in the intracellular calcium ion concentration but not on the TGase2 protein expression level. Enzyme substrate analysis revealed that TGase2-mediated protein modification promoted protein aggregation concurrently with decreasing water solubility. Moreover, treatment with KCC009, a TGase2 inhibitor, abrogated ER stress-induced TGase2 activation and subsequent protein aggregation. However, TGase2 activation had no effect on ER stress-induced cell death. These results demonstrate that the accumulation of misfolded proteins activates TGase2, which further accelerates the formation of protein aggregates. Therefore, we suggest that inhibition of TGase2 may be a novel strategy by which to prevent the protein aggregation in age-related degenerative diseases. PMID:24481335

  13. Meditation leads to reduced default mode network activity beyond an active task.

    PubMed

    Garrison, Kathleen A; Zeffiro, Thomas A; Scheinost, Dustin; Constable, R Todd; Brewer, Judson A

    2015-09-01

    Meditation has been associated with relatively reduced activity in the default mode network, a brain network implicated in self-related thinking and mind wandering. However, previous imaging studies have typically compared meditation to rest, despite other studies having reported differences in brain activation patterns between meditators and controls at rest. Moreover, rest is associated with a range of brain activation patterns across individuals that has only recently begun to be better characterized. Therefore, in this study we compared meditation to another active cognitive task, both to replicate the findings that meditation is associated with relatively reduced default mode network activity and to extend these findings by testing whether default mode activity was reduced during meditation, beyond the typical reductions observed during effortful tasks. In addition, prior studies had used small groups, whereas in the present study we tested these hypotheses in a larger group. The results indicated that meditation is associated with reduced activations in the default mode network, relative to an active task, for meditators as compared to controls. Regions of the default mode network showing a Group × Task interaction included the posterior cingulate/precuneus and anterior cingulate cortex. These findings replicate and extend prior work indicating that the suppression of default mode processing may represent a central neural process in long-term meditation, and they suggest that meditation leads to relatively reduced default mode processing beyond that observed during another active cognitive task. PMID:25904238

  14. Meditation leads to reduced default mode network activity beyond an active task

    PubMed Central

    Garrison, Kathleen A.; Zeffiro, Thomas A.; Scheinost, Dustin; Constable, R. Todd; Brewer, Judson A.

    2015-01-01

    Meditation has been associated with relatively reduced activity in the default mode network, a brain network implicated in self-related thinking and mind wandering. However, previous imaging studies have typically compared meditation to rest despite other studies reporting differences in brain activation patterns between meditators and controls at rest. Moreover, rest is associated with a range of brain activation patterns across individuals that has only recently begun to be better characterized. Therefore, this study compared meditation to another active cognitive task, both to replicate findings that meditation is associated with relatively reduced default mode network activity, and to extend these findings by testing whether default mode activity was reduced during meditation beyond the typical reductions observed during effortful tasks. In addition, prior studies have used small groups, whereas the current study tested these hypotheses in a larger group. Results indicate that meditation is associated with reduced activations in the default mode network relative to an active task in meditators compared to controls. Regions of the default mode showing a group by task interaction include the posterior cingulate/precuneus and anterior cingulate cortex. These findings replicate and extend prior work indicating that suppression of default mode processing may represent a central neural process in long-term meditation, and suggest that meditation leads to relatively reduced default mode processing beyond that observed during another active cognitive task. PMID:25904238

  15. 40 CFR 745.325 - Lead-based paint activities: State and Tribal program requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES State and Indian Tribal Programs § 745.325 Lead-based paint activities: State and... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Lead-based paint activities: State...

  16. 40 CFR 745.325 - Lead-based paint activities: State and Tribal program requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES State and Indian Tribal Programs § 745.325 Lead-based paint activities: State and... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Lead-based paint activities: State...

  17. 40 CFR 745.233 - Lead-based paint activities requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Lead-based paint activities requirements. 745.233 Section 745.233 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES Lead-Based Paint Activities § 745.233...

  18. 40 CFR 745.325 - Lead-based paint activities: State and Tribal program requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES State and Indian Tribal Programs § 745.325 Lead-based paint activities: State and... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Lead-based paint activities: State...

  19. 40 CFR 745.325 - Lead-based paint activities: State and Tribal program requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES State and Indian Tribal Programs § 745.325 Lead-based paint activities: State and... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Lead-based paint activities: State...

  20. Activity-based analyses lead to better decision making.

    PubMed

    Player, S

    1998-08-01

    Activity-based costing (ABC) and activity-based management (ABM) are cost-management tools that are relatively new to the healthcare industry. ABC is used for strategic decision making. It assesses the costs associated with specific activities and resources and links those costs to specific internal and external customers of the healthcare enterprise (e.g., patients, service lines, and physician groups) to determine the costs associated with each customer. This cost information then can be adjusted to account for anticipated changes and to predict future costs. ABM, on the other hand, supports operations by focusing on the causes of costs and how costs can be reduced. It assesses cost drivers that directly affect the cost of a product or service, and uses performance measures to evaluate the financial or nonfinancial benefit an activity provides. By identifying each cost driver and assessing the value the element adds to the healthcare enterprise, ABM provides a basis for selecting areas that can be changed to reduce costs. PMID:10182280

  1. Impact of activator type on the immobilisation of lead in fly ash-based geopolymer.

    PubMed

    Lee, Sujeong; van Riessen, Arie; Chon, Chul-Min; Kang, Nam-Hee; Jou, Hyeong-Tae; Kim, Youn-Joong

    2016-03-15

    Immobilisation of heavy metals in geopolymers has attracted attention as a potential means of treating toxic wastes. Lead is known to be effectively immobilised in a geopolymer matrix, but detailed explanation for the mechanisms involved and the specific chemical form of lead are not fully understood. To reveal the effect of the activator types on the immobilisation of lead in geopolymers, 0.5 and 1.0wt% lead in the form of lead nitrate was mixed with fly ash and alkaline activators. Different alkaline activators (either combined sodium hydroxide and sodium silicate or sodium aluminate) were used to achieve the target Si:Al ratios 2.0 and 5.0 in geopolymers. Zeolite was formed in aluminate-activated geopolymers having a Si:Al ratio of 2.0, but the zeolite crystallization was suppressed as lead content increased. No specific crystalline phase of lead was detected by X-ray diffraction, electron diffraction or FT-IR spectrometry. In fact, double Cs corrected TEM analysis revealed that lead was evenly distributed with no evidence of formation of a specific lead compound. A sequential extraction procedure for fractionation of lead showed that lead did not exist as an exchangeable ion in geopolymers, regardless of activator type used. Aluminate activation is shown to be superior in the immobilisation of lead because about 99% of extracted lead existed in the oxidizing and residual fractions. PMID:26642447

  2. Graduate Student Scholarly Activities; Gender and Perceived Program Support.

    ERIC Educational Resources Information Center

    Stein, Elizabeth L.; Weidman, John C.

    A segment of the socialization process of graduate students seeking advanced degrees in education is explored in order to discover how the students are socialized to the norm of cognitive rationality. The correlates of graduate student participation in certain scholarly activities with the students' perceptions of their academic program are…

  3. The use of nanometer tetrabasic lead sulfate as positive active material additive for valve regulated lead-acid battery

    NASA Astrophysics Data System (ADS)

    Lang, Xiaoshi; Wang, Dianlong; Hu, Chiyu; Tang, Shenzhi; Zhu, Junsheng; Guo, Chenfeng

    2014-12-01

    Conventional tetrabasic lead sulfate used as positive active material additive shows the results of the low effective lead dioxide conversion rate due to the large grain size and crossed the crystal structure. In this paper, we study on a type of nanometer tetrabasic lead sulfate. Through the XRD and SEM test and Material Studio software calculation, the purity of tetrabasic lead sulfate is very high, the grain size of the nanometer 4BS is almost unanimous, and can be controlled below 200 nm. When charged and discharged in 1.75 V-2.42 V with the current density of 40 mA g-1, 80 mA g-1 and 160 mA g-1, the effective lead dioxide conversion rate of nanometer 4BS after formation can achieve to 83.48%, 71.42%, and 66.96%. Subsequently, the nanometer 4BS as additive is added to positive paste of lead-acid battery. When the batteries are tested galvanostatically between 1.75 V and 2.42 V at 0.25 C charge and 0.5 C discharge rates at room temperature. The ratio of adding nanometer 4BS is 0%, 1% and 4% and the initial discharge specific capacities are 60 mAh g-1, 65 mAh g-1 and 68 mAh g-1. After 80 cycles, the initial discharge capacity of positive active material with 1% nanometer 4BS decreased less than 10%, while adding 4% nanometer 4BS, the initial discharge capacity doesn't decrease obviously.

  4. Student Activism and Student Exclusions in South Africa

    ERIC Educational Resources Information Center

    Koen, Charlton; Cele, Mlungisi; Libhaber, Arial

    2006-01-01

    On average, about 25 percent of students leave higher education (HE) institutions annually in South Africa because they are excluded on academic and financial grounds. To resist such putouts, student boycotts and protests are common despite the fact that student organizations were incorporated into decision-making processes at HE institutions…

  5. Larger Mammalian Body Size Leads to Lower Retroviral Activity

    PubMed Central

    Katzourakis, Aris; Magiorkinis, Gkikas; Lim, Aaron G.; Gupta, Sunetra; Belshaw, Robert; Gifford, Robert

    2014-01-01

    Retroviruses have been infecting mammals for at least 100 million years, leaving descendants in host genomes known as endogenous retroviruses (ERVs). The abundance of ERVs is partly determined by their mode of replication, but it has also been suggested that host life history traits could enhance or suppress their activity. We show that larger bodied species have lower levels of ERV activity by reconstructing the rate of ERV integration across 38 mammalian species. Body size explains 37% of the variance in ERV integration rate over the last 10 million years, controlling for the effect of confounding due to other life history traits. Furthermore, 68% of the variance in the mean age of ERVs per genome can also be explained by body size. These results indicate that body size limits the number of recently replicating ERVs due to their detrimental effects on their host. To comprehend the possible mechanistic links between body size and ERV integration we built a mathematical model, which shows that ERV abundance is favored by lower body size and higher horizontal transmission rates. We argue that because retroviral integration is tumorigenic, the negative correlation between body size and ERV numbers results from the necessity to reduce the risk of cancer, under the assumption that this risk scales positively with body size. Our model also fits the empirical observation that the lifetime risk of cancer is relatively invariant among mammals regardless of their body size, known as Peto's paradox, and indicates that larger bodied mammals may have evolved mechanisms to limit ERV activity. PMID:25033295

  6. Sampling and Analysis for Lead in Water and Soil Samples on a University Campus: A Student Research Project.

    ERIC Educational Resources Information Center

    Butala, Steven J.; Zarrabi, Kaveh

    1995-01-01

    Describes a student research project that determined concentrations of lead in water drawn from selected drinking fountains and in selected soil samples on the campus of the University of Nevada, Las Vegas. (18 references) (DDR)

  7. Conservation II. Science Activities in Energy. [Student's and] Teacher's Guide.

    ERIC Educational Resources Information Center

    Oak Ridge Associated Universities, TN.

    Designed for science students in fourth, fifth, and sixth grades, the activities in this unit illustrate principles and problems related to the conservation of energy. Eleven student activities using art, economics, arithmetic, and other skills and disciplines help teachers directly involve students in exploring scientific questions and making…

  8. Performing Keypunch Activities. Student Manual and Instructor's Manual.

    ERIC Educational Resources Information Center

    Chapman, Pat

    Supporting performance objective 55 of the V-TECS (Vocational-Technical Education Consortium of States) Secretarial Catalog, both a set of student materials and an instructor's manual on performing keypunch activities are included in this packet. (Keypunch equipment is required.) The student materials include three student activities and a…

  9. Students as Doers: Examples of Successful E-Learning Activities

    ERIC Educational Resources Information Center

    Tammelin, Maija; Peltonen, Berit; Puranen, Pasi; Auvinen, Lis

    2012-01-01

    This paper discusses learning language and communication activities that focus on students' concrete involvement in their learning process. The activities first deal with student-produced blogs and digital videos in business Spanish. They then present student-produced podcasts for Swedish business communication learners that are meant for…

  10. Students' Attitudes toward an After-School Physical Activity Programme

    ERIC Educational Resources Information Center

    Agbuga, Bulent; Xiang, Ping; McBride, Ron

    2013-01-01

    Though considerable research on student attitudes has been conducted in physical education, little information exists concerning student attitudes toward after-school physical activity programmes. This study assessed students' attitudes toward their after-school physical activity programme located in southwest Texas, USA. Participants included 158…

  11. Silent Students' Participation in a Large Active Learning Science Classroom

    ERIC Educational Resources Information Center

    Obenland, Carrie A.; Munson, Ashlyn H.; Hutchinson, John S.

    2012-01-01

    Active learning in large science classrooms furthers opportunities for students to engage in the content and in meaningful learning, yet students can still remain anonymously silent. This study aims to understand the impact of active learning on these silent students in a large General Chemistry course taught via Socratic questioning and…

  12. Transfer Student Success: Educationally Purposeful Activities Predictive of Undergraduate GPA

    ERIC Educational Resources Information Center

    Fauria, Renee M.; Fuller, Matthew B.

    2015-01-01

    Researchers evaluated the effects of Educationally Purposeful Activities (EPAs) on transfer and nontransfer students' cumulative GPAs. Hierarchical, linear, and multiple regression models yielded seven statistically significant educationally purposeful items that influenced undergraduate student GPAs. Statistically significant positive EPAs for…

  13. Leading Online: An Autoethnography Focused on Leading an Instructional Focus on Student Learning in an Online School

    ERIC Educational Resources Information Center

    Lancaster, Sally Ann

    2012-01-01

    The purpose in writing this autoethnography was to describe, analyze and interpret one leader's experience in leading a group of online teachers. I specifically wanted to identify the characteristics of an online learning environment that triggered teachers to focus on management issues rather than instructional learning issues; that is what…

  14. Voluntary participation in an active learning exercise leads to a better understanding of physiology.

    PubMed

    Carvalho, Helena; West, Crystal A

    2011-03-01

    Students learn best when they are focused and thinking about the subject at hand. To teach physiology, we must offer opportunities for students to actively participate in class. This approach aids in focusing their attention on the topic and thus generating genuine interest in the mechanisms involved. This study was conducted to determine if offering voluntary active learning exercises would improve student understanding and application of the material covered. To compare performance, an anonymous cardiorespiratory evaluation was distributed to two groups of students during the fall (control, n = 168) and spring (treatment, n = 176) semesters. Students in both groups were taught by traditional methods, and students in the treatment group had the option to voluntary participate in two additional active learning exercises: 1) a small group discussion, where students would discuss a physiology topic with their Teaching Assistant before running BIOPAC software for the laboratory exercise and 2) a free response question, where students anonymously responded to one short essay question after the laboratory exercise. In these formative assessments, students received feedback about their present state of learning from the discussion with their peers and also from the instructor comments regarding perceived misconceptions. As a result of the participation in these activities, students in the treatment group had a better overall performance [χ(2) (degree of freedom = 1) = 31.2, P < 0.001] on the evaluation (treatment group: 62% of responses correct and control group: 49%) with an observed difference of 13% (95% confidence interval: 8, 17). In conclusion, this study presents sufficient evidence that when the opportunity presents itself, students become active participants in the learning process, which translates into an improvement in their understanding and application of physiological concepts. PMID:21386002

  15. Voluntary Participation in an Active Learning Exercise Leads to a Better Understanding of Physiology

    ERIC Educational Resources Information Center

    Carvalho, Helena; West, Crystal A.

    2011-01-01

    Students learn best when they are focused and thinking about the subject at hand. To teach physiology, we must offer opportunities for students to actively participate in class. This approach aids in focusing their attention on the topic and thus generating genuine interest in the mechanisms involved. This study was conducted to determine if…

  16. 24 CFR 35.935 - Ongoing lead-based paint maintenance activities.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ..., Department of Housing and Urban Development LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES Rehabilitation § 35.935 Ongoing lead-based paint maintenance activities. In the case of a rental... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Ongoing lead-based...

  17. 24 CFR 35.1220 - Ongoing lead-based paint maintenance activities.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ..., Department of Housing and Urban Development LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES Tenant-Based Rental Assistance § 35.1220 Ongoing lead-based paint maintenance activities... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Ongoing lead-based...

  18. 24 CFR 35.935 - Ongoing lead-based paint maintenance activities.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., Department of Housing and Urban Development LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES Rehabilitation § 35.935 Ongoing lead-based paint maintenance activities. In the case of a rental... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Ongoing lead-based...

  19. 24 CFR 35.1220 - Ongoing lead-based paint maintenance activities.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., Department of Housing and Urban Development LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES Tenant-Based Rental Assistance § 35.1220 Ongoing lead-based paint maintenance activities... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Ongoing lead-based...

  20. 40 CFR 745.238 - Fees for accreditation and certification of lead-based paint activities.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Fees for accreditation and certification of lead-based paint activities. 745.238 Section 745.238 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES Lead-Based...

  1. 24 CFR 35.1220 - Ongoing lead-based paint maintenance activities.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ..., Department of Housing and Urban Development LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES Tenant-Based Rental Assistance § 35.1220 Ongoing lead-based paint maintenance activities... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Ongoing lead-based...

  2. 24 CFR 35.935 - Ongoing lead-based paint maintenance activities.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ..., Department of Housing and Urban Development LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES Rehabilitation § 35.935 Ongoing lead-based paint maintenance activities. In the case of a rental... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Ongoing lead-based...

  3. 24 CFR 35.935 - Ongoing lead-based paint maintenance activities.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ..., Department of Housing and Urban Development LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES Rehabilitation § 35.935 Ongoing lead-based paint maintenance activities. In the case of a rental... 24 Housing and Urban Development 1 2014-04-01 2014-04-01 false Ongoing lead-based...

  4. 24 CFR 35.1220 - Ongoing lead-based paint maintenance activities.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ..., Department of Housing and Urban Development LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES Tenant-Based Rental Assistance § 35.1220 Ongoing lead-based paint maintenance activities... 24 Housing and Urban Development 1 2013-04-01 2013-04-01 false Ongoing lead-based...

  5. 24 CFR 35.935 - Ongoing lead-based paint maintenance activities.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ..., Department of Housing and Urban Development LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES Rehabilitation § 35.935 Ongoing lead-based paint maintenance activities. In the case of a rental... 24 Housing and Urban Development 1 2013-04-01 2013-04-01 false Ongoing lead-based...

  6. 75 FR 66087 - Agency Information Collection Activities; Proposed Collection; Comment Request; Residential Lead...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-27

    ... Information Collection Activities; Proposed Collection; Comment Request; Residential Lead-Based Paint Hazard... Office of Management and Budget (OMB). This ICR, entitled: ``Residential Lead-Based Paint Hazard... parties. Title: Residential Lead-Based Paint Hazard Disclosure Requirements. ICR numbers: EPA ICR No....

  7. Lead Exposure Is Associated with Decreased Serum Paraoxonase 1 (PON1) Activity and Genotypes

    PubMed Central

    Li, Wan-Fen; Pan, Mei-Hung; Chung, Meng-Chu; Ho, Chi-Kung; Chuang, Hung-Yi

    2006-01-01

    Lead exposure causes cardiac and vascular damage in experimental animals. However, there is considerable debate regarding the causal relationship between lead exposure and cardiovascular dysfunction in humans. Paraoxonase 1 (PON1), a high-density lipoprotein-associated antioxidant enzyme, is capable of hydrolyzing oxidized lipids and thus protects against atherosclerosis. Previous studies have shown that lead and several other metal ions are able to inhibit PON1 activity in vitro. To investigate whether lead exposure has influence on serum PON1 activity, we conducted a cross-sectional study of workers from a lead battery manufactory and lead recycling plant. Blood samples were analyzed for whole-blood lead levels, serum PON1 activity, and three common PON1 polymorphisms (Q192R, L55M, −108C/T). The mean blood lead level (± SD) of this cohort was 27.1 ± 15 μg/dL. Multiple linear regression analysis showed that blood lead levels were significantly associated with decreased serum PON1 activity (p < 0.001) in lead workers. This negative correlation was more evident for workers who carry the R192 allele, which has been suggested to be a risk factor for coronary heart disease. Taken together, our results suggest that the decrease in serum PON1 activity due to lead exposure may render individuals more susceptible to atherosclerosis, particularly subjects who are homozygous for the R192 allele. PMID:16882531

  8. Teaching massage to nursing students of geriatrics through active learning.

    PubMed

    Adler, Patricia A

    2009-03-01

    The use of massage in nursing practice has declined through the years in favor of high-tech interventions. This article describes a project using active learning to teach nursing students massage with dementia residents in assisted living. Students participated in a workshop to practice basic relaxation massage techniques with the guidance of their clinical instructor and then provided massages to resident volunteers. Afterward, students discussed their experience and completed a resident assessment form. The students requested more such activities, and the residents and facility management invited the students to return for another session. The instructor observed growth in the students' assessment skills and in their confidence. Use of massage to teach nursing students how to care for and relate to older adults with cognitive impairment is recommended. Further research is needed on the use of massage as an active learning method for nursing students in long-term care. PMID:19181909

  9. Management concerns about known and potential impacts of lead use in shooting and in fishing activities

    USGS Publications Warehouse

    Goddard, C.I.; Leonard, N.J.; Stang, D.L.; Wingate, P.J.; Rattner, B.A.; Franson, J.C.; Sheffield, S.R.

    2008-01-01

    We present a summary of the technical review, jointly requested by the American Fisheries Society and The Wildlife Society, addressing the hazards to wildlife resulting from lead objects or fragments introduced into aquatic and terrestrial environments from the use of ammunition and fishing tackle. Impacts from lead are well documented in humans, as well as in terrestrial and aquatic organisms. Concern about impacts from lead ammunition and fishing tackle has resulted in the development of non-lead alternatives, educational campaigns, and regulations to restrict their use. This article discusses the general biological impacts of lead exposure from fishing and shooting activities to fish, wildlife, and humans; summarizes existing and proposed regulations to reduce lead exposure to biota; reviews alternatives to lead materials that are currently available for fishing; and outlines options for further actions to reduce wildlife and human exposure to lead from fishing activities.

  10. Activity Preferences of Middle School Physical Education Students.

    ERIC Educational Resources Information Center

    Greenwood, Michael; Stillwell, Jim; Byars, Allyn

    2001-01-01

    Investigated the physical education activity preferences of middle school students who completed a checklist featuring a variety of activities. Overall, middle school boys and girls both differed and agreed on their interests for specific activities. Most students liked basketball, bicycling, roller skating, soccer, swimming, and volleyball but…

  11. Effect of Lead stress on phosphatase activity and reducing power assay of Triticum aestivum.

    PubMed

    Gubrelay, U; Agnihotri, R K; Shrotriya, S; Sharma, R

    2015-01-01

    Lead (Pb) is a highly toxic heavy metal for both plants and animals; the environment is increasingly polluted with heavy metals and reduces crop productivity. Plants possess homeostatic mechanisms that allow them to keep correct concentrations of essential metal ions in cellular compartments and to minimize the damaging effects of an excess of nonessential ones. One of their adverse effects on plants are the generation of harmful active oxygen species, leading to oxidative stress and the antioxidative activity seems to be of fundamental importance for adaptive response of plant against environmental stress. The present study explores the effects of lead (soil treated twice/ week) with (10, 30 and 60 mM) on the specific activities of phosphatases which might lead to reducing power assay in (Triticum aestivum PBW344) seedling. A significant decrease in the redox potential of shoot compared to root was observed at the similar concentration of lead. A similar trend on leaves was also noted. Acid and alkaline phosphatase activities were significantly higher in roots than in shoot at all the three concentration of lead i.e. 10, 30 and 60 mM, compared to controls. The above mentioned changes were more pronounced at 60 mM concentration of lead than two other concentrations. These results lead us to suggest that increased lead concentration in soil might lead to adverse effects on plant growth and phosphatase activities. PMID:26107501

  12. Innovated application of mechanical activation to separate lead from scrap cathode ray tube funnel glass.

    PubMed

    Yuan, Wenyi; Li, Jinhui; Zhang, Qiwu; Saito, Fumio

    2012-04-01

    The disposal of scrap cathode ray tube (CRT) funnel glass has become a global environmental problem due to the rapid shrinkage of new CRT monitor demand, which greatly reduces the reuse for remanufacturing. To detoxificate CRT funnel glass by lead recovery with traditional metallurgical methods, mechanical activation by ball milling was introduced to pretreat the funnel glass. As a result, substantial physicochemical changes have been observed after mechanical activation including chemical breakage and defects formation in glass inner structure. These changes contribute to the easy dissolution of the activated sample in solution. High yield of 92.5% of lead from activated CRT funnel glass by diluted nitric acid leaching and successful formation of lead sulfide by sulfur sulfidization in water have also been achieved. All the results indicate that the application of mechanical activation on recovering lead from CRT funnel glass is efficient and promising, which is also probably appropriate to detoxificate any other kind of leaded glass. PMID:22385285

  13. Activism in Concrete: Student Union, San Francisco State University

    ERIC Educational Resources Information Center

    Progressive Architecture, 1978

    1978-01-01

    The San Francisco State University Student Union is a futurist design of two steel space-frame pyramids. Each contains a stairway leading to four partial floors that diminish in size as the pyramid tapers. (Author/MLF)

  14. Oxalate Blockage of Calcium and Iron: A Student Learning Activity.

    ERIC Educational Resources Information Center

    Walker, Noojin

    1988-01-01

    Describes a student learning activity used to teach the meaning of percentage composition, mole concept, selective precipitation, and limiting factors. Presents two word problems and their solutions. (CW)

  15. Students' Representations of Scientific Practice during a Science Internship: Reflections from an activity-theoretic perspective

    NASA Astrophysics Data System (ADS)

    Hsu, Pei-Ling; van Eijck, Michiel; Roth, Wolff-Michael

    2010-06-01

    Working at scientists' elbows is one suggestion that educators make to improve science education, because such "authentic experiences" provide students with various types of science knowledge. However, there is an ongoing debate in the literature about the assumption that authentic science activities can enhance students' understandings of scientific practice. The purpose of the study is to further address the debate in terms of the ethnographic data collected during an internship programme for high school students right through to their public presentations at the end. Drawing on activity theory to analyse these presentations, we found that students presented scientific practice as accomplished by individual personnel without collaboration in the laboratory. However, our ethnographic data of their internship interaction show that students have had conversations about the complex collaborations within and outside the laboratory. This phenomenon leads us to claim that students experienced authentic science in their internships, but their subsequent representations of authentic science are incomplete. That is, participating in authentic science internships and reporting scientific practice are embedded activities that constitute different goals and conditions rather than unrefracted reflections of one another. The debate on the influence on students' understanding of science practice is not simply related to situating students in authentic science contexts, but also related to students' values and ideology of reporting their understanding of and about science. To help students see these "invisible" moments of science practice is therefore crucial. We make suggestions for how the invisible in and of authentic science may be made visible.

  16. Institutional Liability for Student Activities and Organizations.

    ERIC Educational Resources Information Center

    Richmond, Douglas R.

    1990-01-01

    Examines higher education institutional liability in the following areas: (1) in tort, based on negligence, for physical harm to students; (2) in tort, for defamation flowing from student media; and (3) in contract, arising out of student organizations' business relationships with third parties. (222 references) (MLF)

  17. Student Technological Creativity Using Online Problem-Solving Activities

    ERIC Educational Resources Information Center

    Chang, Yu-Shan

    2013-01-01

    The purpose of this study was to investigate the effects of online (web-based) creative problem-solving (CPS) activities on student technological creativity and to examine the characteristics of student creativity in the context of online CPS. A pretest-posttest quasi-experiment was conducted with 107 fourth-grade students in Taiwan. The…

  18. An Activity to Teach Students about Schematic Processing

    ERIC Educational Resources Information Center

    Isbell, Linda M.; Tyler, James M.; Burns, Kathleen C.

    2007-01-01

    We designed a classroom activity to foster students' understanding of what schemas are and how they function. We used a video of the instructor as an infant to illustrate how schemas influence gender stereotyping. Before the video, we told students that the baby was either a boy or a girl. After the video, students rated whether the baby would…

  19. Students' Activity Focus in Online Asynchronous Peer Learning Forums

    ERIC Educational Resources Information Center

    Gaspar, Alessio; Langevin, Sarah; Boyer, Naomi; Armitage, William

    2010-01-01

    This qualitative study explores how using Peer Learning Forums (PLF) in an online asynchronous computer programming course can be analyzed to derive information about Student Activity Focus (SAF) for adult Information Technology students. Three instruments are proposed to assist instructors classify questions posted by students on these forums,…

  20. Examining Participation of University Students in Recreational Entertainment Marketing Activities

    ERIC Educational Resources Information Center

    Pala, Adem

    2016-01-01

    The aim of this study was to examine participation of university students in recreational entertainment marketing activities. The survey population consisted of university student in Marmara University Province of Istanbul. The sample constituted a total of 272 students (150 male and 122 female), determined by circumstantial method. The survey…

  1. Science Teaching and Learning Activities and Students' Engagement in Science

    NASA Astrophysics Data System (ADS)

    Hampden-Thompson, Gillian; Bennett, Judith

    2013-06-01

    The purpose of this analysis is to describe the variation in students' reports of engagement in science across science teaching and learning activities. In addition, this study examines student and school characteristics that may be associated with students' levels of engagement in science. Data are drawn from the Programme for International Student Assessment 2006 study. The analysis employs a quantitative approach that includes descriptive and inferential statistics to examine three measures of student engagement for a nationally representative sample of approximately 12,000 15-year-old students in the UK. The main results indicate that there is an association between students' motivation towards science, enjoyment of science and future orientation towards science, and the frequency in which various teaching and learning activities take place in the classroom. Understanding student engagement in science and the factors that influence it is essential in addressing the issue of uptake of science after compulsory schooling.

  2. Who Knows Where the Path Leads? Educational Goals and Student Success.

    ERIC Educational Resources Information Center

    Nolan, Bernie

    1989-01-01

    Underscores the importance of student goal identification and student tracking for both the community college and its students. Reviews research findings indicating that large proportions of community college students are confused about their educational goals. Highlights methods used to help clarify their goals and monitor their progress toward…

  3. Leading Inclusive Reform for Students with Disabilities: A School- and Systemwide Approach

    ERIC Educational Resources Information Center

    Theoharis, George; Causton, Julie

    2014-01-01

    It is of great importance to maximize access to general education for all students with disabilities. This article focuses on how leaders create inclusive schools for all students--inclusive school reform. Inclusive school reform can result in all students with disabilities being placed into general education settings (including students with…

  4. Cardiovascular risk factors and physical activity among university students in Somaliland.

    PubMed

    Ali, Mahdi; Yusuf, Hassan Ismail; Stahmer, Jens; Rahlenbeck, Sibylle I

    2015-04-01

    Physical inactivity is a well-known risk factor for the development of cardiovascular diseases and counts as fourth leading cause of death worldwide. The study aimed to elucidate to what extent cardiovascular risk factors exist in university students in Somaliland. In a cross-sectional survey, self-administered questionnaires were used to elucidate existence of cardiovascular risk factors in 173 university students (117 male, 56 female) in Hargeisa, Somaliland. Information elucidated included socio-economic and demographic data in addition to questions on coffee intake, on physical activity behavior, type of sport/activity and intensity and duration. Height and weight were taken, as was blood pressure (BP). Median age was 23 years in male and 20 years in female students. Mean BMI was 19.7 in male and 21.8 in female students. The prevalence rates of elevated BP and overweight (BMI ≥ 25) in female and male students were, 0 versus 9 and 14 versus 7 %, respectively. Coffee consumption was reported by 39 % of students. None of the female students reported smoking cigarettes, while 5.1 % of the male students did. Physical inactivity was reported by 52 % of the female students and 27 % of the male students (p = 0.01). Overall, male students reported a higher degree and intensity of physical activity. The prevalence of cardiovascular risk factors is low in female and male university students in Somaliland. However, the results demonstrate a high degree of physical inactivity and overweight might become a problem in the future. This issue should be addressed by increasing the motivation and opportunities for physical activity in students. PMID:25179818

  5. Students' Learning Activities While Studying Biological Process Diagrams

    NASA Astrophysics Data System (ADS)

    Kragten, Marco; Admiraal, Wilfried; Rijlaarsdam, Gert

    2015-08-01

    Process diagrams describe how a system functions (e.g. photosynthesis) and are an important type of representation in Biology education. In the present study, we examined students' learning activities while studying process diagrams, related to their resulting comprehension of these diagrams. Each student completed three learning tasks. Verbal data and eye-tracking data were collected as indications of students' learning activities. For the verbal data, we applied a fine-grained coding scheme to optimally describe students' learning activities. For the eye-tracking data, we used fixation time and transitions between areas of interest in the process diagrams as indices of learning activities. Various learning activities while studying process diagrams were found that distinguished between more and less successful students. Results showed that between-student variance in comprehension score was highly predicted by meaning making of the process arrows (80%) and fixation time in the main area (65%). Students employed successful learning activities consistently across learning tasks. Furthermore, compared to unsuccessful students, successful students used a more coherent approach of interrelated learning activities for comprehending process diagrams.

  6. Working in Pharmacies. Instructor's Guide. Student's Manual. Student Learning Activities. Second Revised Edition.

    ERIC Educational Resources Information Center

    Driever, Carl W.; And Others

    This document combines three separately bound volumes, a student manual, an instructor's guide, and student learning activities designed for students who are either in beginning-level pharmacy technician courses or considering careers in pharmacy. The material is intended to relate training experience to information studied in the classroom. The…

  7. Instructor Language and Student Active Engagement in Elementary Students with Autism Spectrum Disorder

    ERIC Educational Resources Information Center

    Sparapani, Nicole J.

    2013-01-01

    Few studies have examined how instructor variables relate to student performance measures for individuals with autism spectrum disorder (ASD). The purpose of this study was to examine instructor language and student active engagement in general and special education classrooms for students with ASD. This study included participants (n = 196…

  8. Staff and Student Experiences of Dialogue Days, a Student Engagement Activity

    ERIC Educational Resources Information Center

    Asghar, Mandy

    2016-01-01

    This paper reports the findings from a descriptive phenomenological exploration of the lived experience of dialogue days, a student engagement activity, from the perspectives of staff and students. I suggest that dialogue days enhance the relational and emotional aspects of learning with the potential to impact on future student engagement and…

  9. Students as Researchers: An Inclined-Plane Activity.

    ERIC Educational Resources Information Center

    Edwards, Thomas G.

    1995-01-01

    Describes an inquiry activity in which students explore the variables that influence the amount of time it takes a ball to roll down an inclined plane. Relates features of the activity to recommendations in the NCTM Standards. (MKR)

  10. Problem Posing Based on Investigation Activities by University Students

    ERIC Educational Resources Information Center

    da Ponte, Joao Pedro; Henriques, Ana

    2013-01-01

    This paper reports a classroom-based study involving investigation activities in a university numerical analysis course. The study aims to analyse students' mathematical processes and to understand how these activities provide opportunities for problem posing. The investigations were intended to stimulate students in asking questions, to trigger…

  11. Race and Sex Differences in College Student Physical Activity Correlates

    ERIC Educational Resources Information Center

    McArthur, Laura H.; Raedeke, Thomas D.

    2009-01-01

    Objectives: To assess sex/race differences on psychosocial correlates of physical activity among college students. Methods: Survey research protocol. Results: Students (n = 636) exercised an average of 3.5 days per week, with black females being the least active. Across subgroups, health/fitness was rated as the most important motive for exercise,…

  12. College Students' Perceptions of Wellness and Physical Activity

    ERIC Educational Resources Information Center

    Klepfer, Shaley DePolo

    2013-01-01

    College students are increasingly less physically active. Investigation into this problem is important because individuals develop lifelong habits during the college time period. College students' perceptions regarding physical activity and overall wellness are important factors in creating positive change toward healthier lifestyle habits. Based…

  13. Student Activism within Christian College Cultures: A Symbolic Interactionist Perspective

    ERIC Educational Resources Information Center

    Cole, Brian E.

    2014-01-01

    This study contributes to the understanding of the structural and cultural influences of Christian college environments on student activism through the framework of symbolic interactionism (Blumer, 1969; Mead, 1934). The goal of this research was to examine how the students at Christian institutions understand and engage in activism within their…

  14. Middle Level Activities To Involve the Invisible Student.

    ERIC Educational Resources Information Center

    Rimmer, Sue; Arico, Jim

    Involvement in student activities has many advantages for the middle level student. Such activities promote achievement, citizenship, and service to the community while developing self-esteem, self-confidence, and social cooperation. This book is intended as a tool for middle level schools to motivate, develop, guide, involve, and provide middle…

  15. A Career in College Unions and Student Activities

    ERIC Educational Resources Information Center

    Association of College Unions International (NJ1), 2009

    2009-01-01

    If you are looking for a rewarding career where you can have a positive impact on others, then a career in college unions and student activities may be right for you. The Association of College Unions International (ACUI) created this guide to provide you with a general overview of a career in college unions and student activities. It will…

  16. PETE Students' Perceptions of a Healthy and Active Lifestyle

    ERIC Educational Resources Information Center

    Wilkinson, Carol; Pennington, Todd; Barney, David; Lockhart, Barbara; Hager, Ron; Prusak, Keven

    2014-01-01

    Participants were male and female students (n = 12) in a physical education teacher education (PETE) program with a healthy and active lifestyle management (HALM) focus, at a university in the Intermountain West. The purpose of the study was to examine PETE students' perceptions of a healthy and active lifestyle (HAL). Following inductive content…

  17. Speaking Activities for the Advanced College-Bound Student.

    ERIC Educational Resources Information Center

    Henderson, Don

    Three activities for developing speaking skills of advanced English as second language students are presented. Impromptu speaking, extemporaneous speaking, and debate activities are designed to train students to organize concepts, develop spontaneous oral skills, and enhance confidence and clarity of thought. Impromptu speaking develops…

  18. Student Activity Funds: Creating a System of Controls That Work.

    ERIC Educational Resources Information Center

    Cuzzetto, Charles

    1995-01-01

    Although student-activity funds usually represent a small portion of school-system monies, their very nature makes them a high risk. Outlines three steps for maintaining an efficient and effective system of controls over student-activity funds: (1) identifying control issues; (2) designing a control system; and (3) using checks and balances.…

  19. Physiological Effects of Bouldering Activities in Upper Elementary School Students

    ERIC Educational Resources Information Center

    Fencl, Matthew; Muras, Jennifer; Steffen, Jeff; Battista, Rebecca; Elfessi, Abdulaziz

    2011-01-01

    The purpose of this study was to examine and compare the physiological responses of two different types of bouldering activities in upper elementary school students. As part of a physical education fitness unit, fourth and fifth grade students (N = 64) from two Midwestern elementary schools participated in two different activities at the…

  20. 25 CFR 36.43 - Standard XVI-Student activities.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Standard XVI-Student activities. 36.43 Section 36.43 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR EDUCATION MINIMUM ACADEMIC STANDARDS FOR THE BASIC EDUCATION OF INDIAN CHILDREN AND NATIONAL CRITERIA FOR DORMITORY SITUATIONS Instructional Support § 36.43 Standard XVI—Student activities....

  1. Promoting Physical Activity through Student Life and Academics

    ERIC Educational Resources Information Center

    McDaniel, Tyler; Melton, Bridget F.; Langdon, Jody

    2014-01-01

    Objective: A physical activity passport (PAP) was developed to increase student's physical activity through the collaboration of student life and academics. The purpose was to measure the effectiveness of the PAP. Design: The research design used was a quantitative, descriptive, quasi-experimental design with experimental and control groups.…

  2. Bias in Student Survey Findings from Active Parental Consent Procedures

    ERIC Educational Resources Information Center

    Shaw, Thérèse; Cross, Donna; Thomas, Laura T.; Zubrick, Stephen R.

    2015-01-01

    Increasingly, researchers are required to obtain active (explicit) parental consent prior to surveying children and adolescents in schools. This study assessed the potential bias present in a sample of actively consented students, and in the estimates of associations between variables obtained from this sample. Students (n = 3496) from 36…

  3. Gaining a "Sense of Place": Students' Affective Experiences of Place Leading to Transformative Learning on International Fieldwork

    ERIC Educational Resources Information Center

    Simm, David; Marvell, Alan

    2015-01-01

    This paper reveals the extent to which undergraduate students demonstrate transformative learning whilst on international fieldwork in Barcelona, Spain. Groups of students create a series of discrete active learning situations that allow them and their peers to engage more fully with their locale and in turn experience a deeper understanding of…

  4. Drug and food-deprivation modulation of activity in rats given chronic dietary lead: significance of type of activity measure.

    PubMed

    Yamamoto, B K; Kutscher, C L

    1981-09-01

    In Experiment 1, rats were given a 1% lead acetate diet from Day 100 of life to the termination of the experiment. After 82 days of lead feeding behavioral tests were started. Lead exposure increased wheel-turning hyperactivity produced by food deprivation and phenylethylamine injection. Lead produced no activity change in the unchallenged condition. In the open field, lead-exposure rats were less responsive to the stimulating action of PEA and amphetamine and to the sedating action of pentobarbital. In Experiment 2, the interaction of lead with food deprivation of PEA on wheel-turning was replicated in naive animals given only a 32-day exposure. Chemical analysis was made of tissues. Ingested lead entered the brain. Regional steady-state levels of brain norepinephrine, dopamine and serotonin were not altered by lead treatment when measured following four days of starvation at a time when lead-induced behavioral change was distinct. It was concluded that pharmacological challenges on activity may be sensitive indicators of lead exposure, but the type of activity measure is critical. PMID:7291253

  5. Supporting Students' Knowledge Transfer in Modeling Activities

    ERIC Educational Resources Information Center

    Piksööt, Jaanika; Sarapuu, Tago

    2014-01-01

    This study investigates ways to enhance secondary school students' knowledge transfer in complex science domains by implementing question prompts. Two samples of students applied two web-based models to study molecular genetics--the model of genetic code (n = 258) and translation (n = 245). For each model, the samples were randomly divided into…

  6. FGF2 activates TRPC and Ca2+ signaling leading to satellite cell activation

    PubMed Central

    Liu, Yewei; Schneider, Martin F.

    2013-01-01

    Satellite cells, as stem cells of adult skeletal muscle, are tightly associated with the differentiated muscle fibers and remain quiescent in the absence of muscle damage. In response to an injury, the quiescent satellite cell is activated by soluble factors, including FGFs released from injured myofibers. Using immunostaining, we here first show that TRPC1 channels are highly expressed in satellite cells attached to muscle fibers. Since CD34, a traditional stem cell marker, was recently found to be expressed in skeletal muscle satellite cells we labeled living satellite cells in their physiological niche associated with host FDB fibers using anti-CD34-FITC antibody. We then monitored intra-cellular calcium in anti-CD34-FITC labeled satellite cells attached to muscle fibers using the calcium sensitive dye X rhod-1 which has little fluorescence cross talk with FITC. FGF2 increased intracellular calcium in satellite cells, which was antagonized by the TRPC channel blocker SKF 96365. Immunostaining showed that NFATc3 is highly expressed in satellite cells, but not in host FDB fibers. Elevation of intracellular calcium by FGF2 is accompanied by nuclear translocation of NFATc3 and NFATc2 and by an increase in the number of MyoD positive cells per muscle fiber, both of which were attenuated by TRPC blocker SKF 96365. Our results suggest a novel pathway of satellite cell activation where FGF2 enhances calcium influx through a TRPC channel, and the increased cytosolic calcium leads to both NFATc3 and NFATc2 nuclear translocation and enhanced number of MyoD positive satellite cells per muscle fiber. PMID:24575047

  7. Anger Management and Violence Prevention: A Group Activities Manual for Middle and High School Students.

    ERIC Educational Resources Information Center

    Schmidt, Teresa M.

    This group-activity manual is intended for adolescents who have risk factors on any of the four ecological levels: personal, family, social, and societal. It contains everything needed to lead a group of middle or high school students through this anger-management program. Part 1 provides guidelines to help initiate and implement a support-group…

  8. Contemporary Student Activism: The Educational Contexts of Socially-Responsible Civic Engagement

    ERIC Educational Resources Information Center

    Barnhardt, Cassie L.

    2012-01-01

    Contemporary higher education leaders tend to view campus based activism as an outgrowth of an educational experience that inspires and leads students to engage in civic action for the purpose of alleviating systemic social, economic, or political injustices. Accordingly, this study explores the relationships between the structural characteristics…

  9. 40 CFR 745.325 - Lead-based paint activities: State and Tribal program requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Lead-based paint activities: State and Tribal program requirements. 745.325 Section 745.325 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES State and Indian...

  10. 24 CFR 35.1220 - Ongoing lead-based paint maintenance activities.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 1 2014-04-01 2014-04-01 false Ongoing lead-based paint maintenance activities. 35.1220 Section 35.1220 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES Tenant-Based Rental Assistance §...

  11. Simple Activities to Improve Students' Understanding of Microscopic Friction

    NASA Astrophysics Data System (ADS)

    Corpuz, Edgar de Guzman; Rebello, N. Sanjay

    2012-05-01

    We are currently on the verge of several breakthroughs in nanoscience and technology, and we need to prepare our citizenry to be scientifically literate about the microscopic world. Previous research shows that students' mental models of friction at the atomic level are significantly influenced by their macroscopic ideas. Most students see friction at the microscopic scale as due to the meshing of bumps and valleys and rubbing of atoms. Furthermore, for most students, what is true macroscopically should also be true microscopically. Friction provides a very good context for making students aware of the disparity between the macroscopic and microscopic worlds. In the proceeding sections we will present a series of activities that teachers can use to refine students' ideas of friction at the microscopic level. Several teaching interviews2 were conducted to develop and validate these activities and to establish the concepts/ideas that students adopt as they go through each of the activities.

  12. What Is It "To Lead?": A Nuanced Exploration of Leadership by 3M National Student Fellows

    ERIC Educational Resources Information Center

    Bajer-Koulack, Ameena; Csorba, Emerson Thomas; Lee, Kyuwon Rosa; Smrke, Brianna; Smyth, Tristan

    2014-01-01

    In Canadian higher education, students from across the world interact within tight-knit communities, sharing ideas and developing a wealth of soft and disciplinary skills. With many universities playing host to dozens if not hundreds of student groups, the word "leadership" is uttered by students and faculty in hallways, gymnasiums,…

  13. Does Increasing Hours of Schooling Lead to Improvements in Student Learning? Policy Brief No. 1

    ERIC Educational Resources Information Center

    Sandoval-Hernandez, Andres; Aghakasiri, Parisa; Wild, Justin; Rutkowski, David

    2013-01-01

    Increasing the number of hours students spend in school each year, on the assumption that this will improve student achievement, has become a widespread trend. However, the analysis reported here suggests that this trend can be misguided: the time students spend in the classroom is not always positively related to their academic achievement.…

  14. Teaching the Teacher: Tutoring SimStudent Leads to More Effective Cognitive Tutor Authoring

    ERIC Educational Resources Information Center

    Matsuda, Noboru; Cohen, William W.; Koedinger, Kenneth R.

    2015-01-01

    SimStudent is a machine-learning agent initially developed to help novice authors to create cognitive tutors without heavy programming. Integrated into an existing suite of software tools called Cognitive Tutor Authoring Tools (CTAT), SimStudent helps authors to create an expert model for a cognitive tutor by tutoring SimStudent on how to solve…

  15. The Supervision Dance: Learning to Lead and Follow a Student Teacher

    ERIC Educational Resources Information Center

    Trout, Muffet

    2008-01-01

    This article chronicles the journey of a student teaching supervisor as she worked with one of her student teachers. Early in their relationship, the supervisor's assessment of the student teacher's dispositions for teaching triggered concern. In this self-study, the supervisor was guided by Nel Noddings' (2003) phenomenological description of…

  16. Review of Research on Classroom Communication Patterns, Leading to Improved Student Performance.

    ERIC Educational Resources Information Center

    Hall, Vernon C.

    This is a review of studies designed to assess the attributes of teacher-student interaction predicted to be correlated with student achievement. The paper includes: (1) a summary review of the types of teacher characteristics found to be correlated with student achievement and attitude; (2) a summary of the research done using the Flanders…

  17. The GLAMA (Girls! Lead! Achieve! Mentor! Activate!) physical activity and peer leadership intervention pilot project: A process evaluation using the RE-AIM framework

    PubMed Central

    2012-01-01

    Background Implementing new initiatives and physical activity interventions in schools represents a myriad of challenges that if overcome can potentially facilitate a range of behavioural changes. The aim of this paper is to describe the process evaluation of specific design constructs used in the GLAMA (Girls! Lead! Achieve! Mentor! Activate!) peer leadership and physical activity pilot project. Conducted in a state secondary school in Australia, the intervention was designed to provide students with opportunities to develop leadership skills, school and social connectedness in addition to a range of physical activity experiences. Methods This process evaluation used the RE-AIM (Reach, Efficacy, Adoption, Implementation and Maintenance) health promotion evaluation framework to assess three design constructs of the intervention: the effectiveness of leadership training and leader preparedness, activity suitability and participation, and the barriers to implementation of the intervention and potential solutions to overcome these barriers. As it was not the specific aim of this pilot, no behavioural change data were collected from students. Data were collected using a mixed methods approach including student questionnaires, teachers and researchers reporting on their own observations and feedback from students. Results There were three main considerations evident across more than one RE-AIM dimension that need to be addressed to assist with future GLAMA dissemination. Firstly, the development of teacher, school and student participation. This needs to be through a variety of professional development opportunities for teachers, integration of the program within timetabled classes within the school and promoting the program to students as an opportunity to develop a range of skills to apply to future learning and workplace environments. Secondly, the successful translation of leadership training to practice is necessary to ensure that leaders are effectively able to

  18. Opening-up Classroom Discourse to Promote and Enhance Active, Collaborative and Cognitively-Engaging Student Learning Experiences

    ERIC Educational Resources Information Center

    Hardman, Jan

    2016-01-01

    This paper places classroom discourse and interaction right at the heart of the teaching and learning process. It is built on the argument that high quality talk between the teacher and student(s) provides a fertile ground for an active, highly collaborative and cognitively stimulating learning process leading to improved learning outcomes. High…

  19. Physical Activity, Exercise, and Sedentary Behavior in College Students.

    ERIC Educational Resources Information Center

    Buckworth, Janet; Nigg, Claudio

    2004-01-01

    The authors examined the relationship between physical activity, exercise, and sedentary behaviors in 493 college students who were enrolled in 10 conditioning activity classes and had completed questionnaires at the beginning of the course. They analyzed sedentary activities and indicators of participation in exercise and physical activity by…

  20. 40 CFR 745.230 - Work practice standards for conducting lead-based paint activities: public and commercial...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... CONTROL ACT LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES Lead-Based Paint Activities § 745.230 Work practice standards for conducting lead-based paint activities: public and... lead-based paint activities: public and commercial buildings, bridges and superstructures....

  1. 40 CFR 745.226 - Certification of individuals and firms engaged in lead-based paint activities: target housing and...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES Lead-Based Paint Activities § 745.226 Certification of individuals and firms engaged in lead-based paint activities: target housing... engaged in lead-based paint activities: target housing and child-occupied facilities. 745.226 Section...

  2. 40 CFR 745.226 - Certification of individuals and firms engaged in lead-based paint activities: target housing and...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES Lead-Based Paint Activities § 745.226 Certification of individuals and firms engaged in lead-based paint activities: target housing... engaged in lead-based paint activities: target housing and child-occupied facilities. 745.226 Section...

  3. 40 CFR 745.226 - Certification of individuals and firms engaged in lead-based paint activities: target housing and...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES Lead-Based Paint Activities § 745.226 Certification of individuals and firms engaged in lead-based paint activities: target housing... engaged in lead-based paint activities: target housing and child-occupied facilities. 745.226 Section...

  4. 40 CFR 745.226 - Certification of individuals and firms engaged in lead-based paint activities: target housing and...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES Lead-Based Paint Activities § 745.226 Certification of individuals and firms engaged in lead-based paint activities: target housing... engaged in lead-based paint activities: target housing and child-occupied facilities. 745.226 Section...

  5. 40 CFR 745.229 - Certification of individuals and firms engaged in lead-based paint activities: public and...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... SUBSTANCES CONTROL ACT LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES Lead-Based Paint Activities § 745.229 Certification of individuals and firms engaged in lead-based paint activities... engaged in lead-based paint activities: public and commercial buildings, bridges and superstructures....

  6. 40 CFR 745.230 - Work practice standards for conducting lead-based paint activities: public and commercial...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... CONTROL ACT LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES Lead-Based Paint Activities § 745.230 Work practice standards for conducting lead-based paint activities: public and... lead-based paint activities: public and commercial buildings, bridges and superstructures....

  7. Factors that influence physicians' and medical students' confidence in counseling patients about physical activity.

    PubMed

    Stanford, Fatima Cody; Durkin, Martin W; Stallworth, James Rast; Powell, Caroline Keller; Poston, Mary Beth; Blair, Steven N

    2014-06-01

    Less than half of US adults and two-thirds of US high school students do not meet current US guidelines for physical activity. We examined which factors promoted physicians' and medical students' confidence in counseling patients about physical activity. We established an online exercise survey targeting attending physicians, resident and fellow physicians, and medical students to determine their current level of physical activity and confidence in counseling patients about physical activity. We compared their personal level of physical activity with the 2008 Physical Activity Guidelines of the US Department of Health and Human Services (USDHHS). We administered a survey in 2009 and 2010 that used the short form of the International Physical Activity Questionnaire. A total of 1,949 individuals responded to the survey, of whom 1,751 (i.e., 566 attending physicians, 138 fellow physicians, 806 resident physicians, and 215 medical students) were included in this analysis. After adjusting for their BMI, the odds that physicians and medical students who met USDHHS guidelines for vigorous activity would express confidence in their ability to provide exercise counseling were more than twice that of physicians who did not meet these guidelines. Individuals who were overweight were less likely to be confident than those with normal BMI, after adjusting for whether they met the vigorous exercise guidelines. Physicians with obesity were even less likely to express confidence in regards to exercise counseling. We conclude that physicians and medical students who had a normal BMI and met vigorous USDHHS guidelines were more likely to feel confident about counseling their patients about physical activity. Our findings suggest that graduate medical school education should focus on health promotion in their students, as this will likely lead to improved health behaviors in their students' patient populations. PMID:24682887

  8. Pyrimidine-specific 5' nucleotidase activity in bovine erythrocytes: effect of phlebotomy and lead poisoning

    SciTech Connect

    George, J.W.; Duncan, J.R.

    1982-01-01

    Erythrocyte pyrimidine-specific 5' nucleotidase (PY5'N) (E.C. 3.1.3.5) was measured in healthy, anemic, and lead-poisoned calves to determine whether low activity of PY5'N is associated with the propensity of cattle to develop basophilic stippling of erythrocytes. Low activity of PY5'N has been associated with basophilic stippling of erythrocytes in persons with inherited hemolytic anemia and with lead poisoning. A radiometric technique, using (/sup 14/C)cytidine monophosphate as the substrate, was used to measured PY5'N activity. The erythrocytes from 4 healthy calves had much lower activity (mean of 7.1 +/- 1.6 nmols of (/sup 14/C)cytidine monophosphate hydrolyzed/min/g of hemoglobin) than has been reported for human erythrocytes. The pH response curve of bovine PY5'N was similar to that of the human enzyme, with maximal activity around pH 7. Experimental hemorrhagic anemia in these calves increased PY5'N activity 6-to 7-fold, with peak activity occurring concomitantly with maximum reticulocytosis. Two of the calves were then given lead per os, and the PY5'N activity decreased within 24 hours to base-line values. In the 2 other calves not given lead, the PY5'N activity declined slowly, but did not reach base-line values after 14 days.

  9. Examining the Early Impacts of the Leading Educators Fellowship on Student Achievement and Teacher Retention. Research Report

    ERIC Educational Resources Information Center

    Mihaly, Kata; Master, Benjamin K.; Yoon, Cate

    2015-01-01

    The Leading Educators Fellowship program selects promising mid-career teachers through a competitive application process and develops their skills as leaders of school improvement efforts. The specific objectives of the program are to (1) increase the leadership skills and capacity of teacher leaders in order to improve student achievement in…

  10. Combination of Didactic Lectures and Review Sessions in Endocrinology Leads to Improvement in Student Performance as Measured by Assessments

    ERIC Educational Resources Information Center

    Qureshi, Ayisha; Cozine, Cassy; Rizvi, Farwa

    2013-01-01

    There can be no single best way of learning, and each teaching mode has its own merits and demerits. Didactic lectures in and of themselves are insufficient, whereas a problem-based tutorial alone can be as ineffective. This study was conducted to determine if a problem-based review after didactic lectures would lead to better student performance.…

  11. College Student Motivation to Lead in Relation to Basic Psychological Need Satisfaction and Leadership Self-Efficacy

    ERIC Educational Resources Information Center

    Cho, YoonJung; Harrist, Steve; Steele, Misty; Murn, Lindsay T.

    2015-01-01

    We investigated basic need satisfaction and leadership self-efficacy as psychological antecedents of college students' motivation to lead (MTL), while controlling for individual differences by gender and academic class. Preliminary analyses revealed significant gender differences with males scoring higher than females on calculative MTL and…

  12. Exploring the Relationship between Campus Leadership Development and Undergraduate Student Motivation to Lead among a Malaysian Sample

    ERIC Educational Resources Information Center

    Krauss, Steven Eric; Hamid, Jamaliah Abdul

    2015-01-01

    Despite the number of studies investigating the perceived effectiveness of campus-based leadership development programming among undergraduates, most have focused on programme outcomes and few have investigated the role of the campus environment in enhancing students' motivation to lead, particularly in non-Western contexts. To address these…

  13. Career Paths and Choices Leading to the Senior Student Affairs Office (SSAO) for Women at Community Colleges

    ERIC Educational Resources Information Center

    Biddix, J. Patrick; Giddens, Brandi M.; Darsey, Jessica; Fricks, Jodie Boney; Tucker, Barbara D.; Robertson, Joshua W.

    2012-01-01

    This study examined career paths and choices leading to the Senior Student Affairs Office (SSAO) for women at community colleges. Data were comprised of 57 resumes and 11 interviews from SSAOs during the 2008-2009 academic year. Network analysis paired with interviews offer career track and progression profiles with rationale for women aspirants.…

  14. "Partners in Science": A Model Cooperative Program Introducing High School Teachers and Students to Leading-Edge Pharmaceutical Science

    ERIC Educational Resources Information Center

    Woska, Joseph R., Jr.; Collins, Danielle M.; Canney, Brian J.; Arcario, Erin L.; Reilly, Patricia L.

    2005-01-01

    "Partners in Science" is a cooperative program between Boehringer Ingelheim Pharmaceuticals, Inc. and area high schools in the community surrounding our Connecticut campus. It is a two-phase program that introduces high school students and teachers to the world of drug discovery and leading-edge pharmaceutical research. Phase 1 involves a series…

  15. From Texas to Alaska: Leading Hearing Impaired Elementary Students in Texas to Engage in Science of the Northern Lights Performed in Alaska.

    NASA Astrophysics Data System (ADS)

    Jahn, J. M.; Ibarra, S.; Pfeifer, M. D.; Samara, M.; Michell, R.

    2014-12-01

    Interacting with hearing impaired students who communicate using auditory/oral methods provides challenges and opportunities to education/outreach activities. Despite many advances in assistive technologies, these hearing impaired students will learn much less incidentally than their peers with typical hearing. In other words, they will often require repeated auditory and perhaps visual reinforcement in order to learn a new word or a new concept. This need leads to a much more deliberate and conscious interaction between educators or scientists and the students. We are reporting from a unique joint project between the Sunshine Cottage School for Deaf Children and the Southwest Research Institute (SwRI), to bring actual space research to life for hearing impaired elementary school students. During this project, we combined the unique capabilities of Deaf Education educators with the excitement and wonder of researching the northern lights. For three consecutive winters, we conducted a series of informal yet structured activities each year with fourth and fifth grade students. Our interactions went beyond typical classroom activities and readily available educational materials. Our goal was to engage and excite the students. To do so, we set up a series of interactions and mini-projects that introduced the students to actual research and actual researchers. From "meet the scientists" visits to school over a field trip to the SwRI space research facilities to observing and predicting the aurora using real-time space weather data, we engaged students in the "who" and "how" of doing research and field work in Alaska's winter. Over the course of this project, students connected with a remote school in the interior of Alaska, participated in the excitement of a NASA sounding rocket campaign in in Poker Flat, AK, skyped with researchers and students in Alaska, and made aurora predictions using NOAA real time space weather data. The highlight of the program each year was

  16. Activity of glutathione peroxidase, glutathione reductase, and lipid peroxidation in erythrocytes in workers exposed to lead.

    PubMed

    Kasperczyk, Slawomir; Kasperczyk, Aleksandra; Ostalowska, Alina; Dziwisz, Maria; Birkner, Ewa

    2004-01-01

    The aim of this study was to estimate the activity of glutathione peroxidase (GPx), glutathione reductase (GR), and malondialdehyde (MDA) in erythrocytes in healthy male employees of zinc and lead steelworks who were occupationally exposed to lead over a long period of time (about 15 yr). Workers were divided into two subgroups: the first included employees with low exposure to lead (LL) (n=75) with blood lead level PbB=25-40 microg/dL and the second with high exposure to lead (HL) (n=62) with PbB over 40 microg/dL. Administration workers (n=35) with normal levels of PbB and zinc protoporphyrin in blood (ZPP) in blood were the control group. The activity of GPx significantly increased in LL when compared to the control group (p<0.001) and decreased when compared to the HL group (p=0.036). There were no significant changes in activity of GR in the study population. MDA erythrocyte concentration significantly increased in the HL group compared to the control (p=0.014) and to the LL group (p=0.024). For the people with low exposure to lead (PbB=25-40 microg/dL), the increase of activity of GPx by about 79% in erythrocytes prevented lipid peroxidation and it appears to be the adaptive mechanism against the toxic effect of lead. People with high exposure to lead (with PbB over 40 microg/dL) have shown an increase in MDA concentration in erythrocytes by about 91%, which seems to have resulted from reduced activity of GPx and the lack of increase in activity of GR in blood red cells. PMID:15621928

  17. Neighborhood level health risk assessment of lead paint removal activities from elevated steel bridges

    SciTech Connect

    Conway, R.F.; Cohen, J.T.; Bowers, T.

    1999-07-01

    The New York City Department of Transportation (NYCDOT) has adopted strict containment and monitoring procedures during paint removal activities on its bridges because of the increasing awareness about lead poisoning in children in urban environments and the potential risk of lead-based paint releases during those activities. NYCDOT owns nearly 800 bridges scattered throughout New York City. Before undertaking paint removal activities as part of its ongoing preventive maintenance and rehabilitation program, NYCDOT recently conducted an analysis to determine the public health risk posed to children living near them. The analysis the first of its kind to assess the actual public health risk potential during both routine operations and upset conditions, or accidental releases evaluated the total and incremental blood lead levels from paint removal activities on more than 5,000 children from 6 months to 6 years old. Increases in baseline blood lead levels were estimated using several models, including EPA's Integrated Exposure Uptake Biokinetic (IEUBK) Model. This model estimates steady-state blood lead levels in children, reflecting exposure to lead in multiple media over an extended period of time. Increases in lead exposure from paint removal activities in the area surrounding the bridges was estimated using EPA's Industrial Source Complex (ISC3) model to calculate ambient air and deposition levels. Potential releases from the containment and ancillary equipment used in the paint removal process were modeled based on different release scenarios ranging from routine operations to complete failure of containment. To estimate the paint removal activities' contribution to long-term exterior dust lead levels (and its related interior component), a stochastic simulation model was developed for each block in the study area.

  18. Identifying the Factors Leading to Success: How an Innovative Science Curriculum Cultivates Student Motivation

    NASA Astrophysics Data System (ADS)

    Scogin, Stephen C.

    2016-06-01

    PlantingScience is an award-winning program recognized for its innovation and use of computer-supported scientist mentoring. Science learners work on inquiry-based experiments in their classrooms and communicate asynchronously with practicing plant scientist-mentors about the projects. The purpose of this study was to identify specific factors contributing to the program's effectiveness in engaging students. Using multiple data sources, grounded theory (Strauss and Corbin in Basics of qualitative research. Sage, Newbury Park, 1990) was used to develop a conceptual model identifying the central phenomenon, causal conditions, intervening conditions, strategies, contexts, and student outcomes of the project. Student motivation was determined to be the central phenomenon explaining the success of the program, with student empowerment, online mentor interaction, and authenticity of the scientific experiences serving as causal conditions. Teachers contributed to student motivation by giving students more freedom, challenging students to take projects deeper, encouraging, and scaffolding. Scientists contributed to student motivation by providing explanations, asking questions, encouraging, and offering themselves as partners in the inquiry process. Several positive student outcomes of the program were uncovered and included increased positivity, greater willingness to take projects deeper, better understanding of scientific concepts, and greater commitments to collaboration. The findings of this study provide relevant information on how to develop curriculum, use technology, and train practitioners and mentors to utilize strategies and actions that improve learners' motivation to engage in authentic science in the classroom.

  19. Identifying the Factors Leading to Success: How an Innovative Science Curriculum Cultivates Student Motivation

    NASA Astrophysics Data System (ADS)

    Scogin, Stephen C.

    2016-01-01

    PlantingScience is an award-winning program recognized for its innovation and use of computer-supported scientist mentoring. Science learners work on inquiry-based experiments in their classrooms and communicate asynchronously with practicing plant scientist-mentors about the projects. The purpose of this study was to identify specific factors contributing to the program's effectiveness in engaging students. Using multiple data sources, grounded theory (Strauss and Corbin in Basics of qualitative research. Sage, Newbury Park, 1990) was used to develop a conceptual model identifying the central phenomenon, causal conditions, intervening conditions, strategies, contexts, and student outcomes of the project. Student motivation was determined to be the central phenomenon explaining the success of the program, with student empowerment, online mentor interaction, and authenticity of the scientific experiences serving as causal conditions. Teachers contributed to student motivation by giving students more freedom, challenging students to take projects deeper, encouraging, and scaffolding. Scientists contributed to student motivation by providing explanations, asking questions, encouraging, and offering themselves as partners in the inquiry process. Several positive student outcomes of the program were uncovered and included increased positivity, greater willingness to take projects deeper, better understanding of scientific concepts, and greater commitments to collaboration. The findings of this study provide relevant information on how to develop curriculum, use technology, and train practitioners and mentors to utilize strategies and actions that improve learners' motivation to engage in authentic science in the classroom.

  20. Lead Poisoning

    MedlinePlus

    ... Experiments Stories Lessons Topics Games Activities Lessons MENU Lead Poisoning Kids Homepage Topics Pollution Lead Poisoning What is ... you can avoid contact with it! Sources of Lead Poisoning HOUSE PAINTS: Before1950, lead-based paint was used ...

  1. Aminolevulinic acid-dehydratase activity in green sunfish: An indicator of lead bioavailability in suspended sediments

    SciTech Connect

    Caldwell, C.; Steingraeber, M.

    1995-12-31

    Green sunfish (Lepomis cyanellus, 6-32 g) were exposed for 28 days to suspended sediments and sediments not in suspension (bedded). Blood was collected for aminolevulinic acid-dehydratase activity (ALA-D), hemoglobin and blood lead concentrations, and whole body lead concentrations. Results of the metal analysis of filtered and unfiltered water from both suspended and bedded sediment tests revealed that the majority of the metal was associated with particulate matter in suspension. Fish subjected to suspended sediments (0.2, 1.6, and 21.9 ug/g lead, dry weight) had significantly reduced ALA-D and hemoglobin concentrations than fish in bedded sediments. However, there was no significant correlation between lead concentrations in suspended sediments and ALA-D activity. In addition, there were no significant correlations between ALA-D activity and hemoglobin concentrations. Whole body analysis and blood lead concentrations were not good indicators of lead exposure in sediment tests having relatively low concentrations of lead.

  2. Effects of zinc, copper, and lead toxicity on. cap alpha. -aminolevulinic acid dehydratase activity. [Rats

    SciTech Connect

    Shafiq-ur-Rehman

    1984-07-01

    The distribution of lead, zinc and copper in the human environment has been recognized as a major toxicological factor. Lead ions have been shown to inhibit the activity of delta-aminolevulinic acid dehydratase (delta-ALAD), which is involved in the biosynthesis of heme. Copper also has its inhibitory effect on delta-ALAD activity. A study has shown that the delta-ALAD was activated by zinc ions at physiological concentrations. In view of these reports, it was considered worthwhile to study the poisoning effects of lead, zinc and copper on delta-ALAD activity along with the concentrations of these metal ions in the blood. A possible role of Zn/sup + +/, Cu/sup + +/, and Pb/sup + +/ interaction and their influence on delta-ALAD has been explored in the present paper.

  3. Student Perceptions of a Conceptual Physical Education Activity Course

    ERIC Educational Resources Information Center

    Jenkins, Jayne M.; Jenkins, Patience; Collums, Ashley; Werhonig, Gary

    2006-01-01

    Conceptual physical education (CPE) courses are typically included in university course work to provide students knowledge and skills to engage in physical activity for life. The purpose of this study was to identify CPE course characteristics that contributed to positive and negative student perceptions. Participants included 157 undergraduates…

  4. Perceiving the General: The Multisemiotic Dimension of Students' Algebraic Activity

    ERIC Educational Resources Information Center

    Radford, Luis; Bardino, Caroline; Sabena, Cristina

    2007-01-01

    In this article, we deal with students' algebraic generalizations set in the context of elementary geometric-numeric patterns. Drawing from Vygotsky's psychology, Leont'ev's Activity Theory, and Husserl's phenomenology, we focus on the various semiotic resources mobilized by students in their passage from the particular to the general. Two small…

  5. Measurement of the Construct of Attitude Toward Student Activism.

    ERIC Educational Resources Information Center

    Gold, Joel A.; And Others

    The study measures individual differences in attitude toward student activism on an 18-item Likert type scale. A validity comparison of a known extreme group with a sample from the general student population yielded a significant difference between the means of the groups. Construct validity was evaluated by first testing the differences between…

  6. Do Active-Learning Strategies Improve Students' Critical Thinking?

    ERIC Educational Resources Information Center

    Nelson, Larry P.; Crow, Mary L.

    2014-01-01

    Improving students' ability to recognize work-related problems and apply effective strategies and solutions to fundamental challenges in the field is at the crux of a good college preparation. This paper attempts to investigate if active-learning strategies improve students' critical thinking ability in this regard. Participants were pre-service…

  7. It Takes a Virtual Community: Promoting Collaboration through Student Activities

    ERIC Educational Resources Information Center

    Battista, Ludmila; Forrey, Carol; Stevenson, Carolyn

    2008-01-01

    Distance education provides many nontraditional students with the opportunity to pursue a college education not possible through traditional brick and mortar education. Although not meeting face-to-face, student activities help promote a stronger connection between the classroom and university community. This paper will discuss strategies for…

  8. Teaching Students to Be Active Learners; The Principal's Role.

    ERIC Educational Resources Information Center

    Nelson-Nasca, Donald

    1993-01-01

    Learning is not a spectator sport but requires active learners who integrate new experiences into existing cognitive structures. Principals can help students develop self-responsibility by initiating discussions on this topic, identifying and sharing multiple learning resources for student use, and modeling uses of assignments based on mastery…

  9. Sport and Other Motor Activities of Warsaw Students

    ERIC Educational Resources Information Center

    Biernat, Elzbieta

    2011-01-01

    Study aim: To assess the engagement of students of Warsaw university schools in sports and in recreational motor activities. Material and methods: A cohort (n = 1100) of students attending B.S. or M.S. courses at 6 university schools in Warsaw were studied by applying questionnaire techniques. The questions pertained to participation in…

  10. Total Participation Techniques: Making Every Student an Active Learner

    ERIC Educational Resources Information Center

    Himmele, Persida; Himmele, William

    2011-01-01

    Yes, there are easy-to-use and incredibly effective alternatives to the "stand and deliver" approach to teaching that causes so many students to tune out--or even drop out. Here's your opportunity to explore dozens of ways to engage K-12 students in active learning and allow them to demonstrate the depth of their knowledge and understanding. The…

  11. An Evolving Framework for Describing Student Engagement in Classroom Activities

    ERIC Educational Resources Information Center

    Azevedo, Flavio S.; diSessa, Andrea A.; Sherin, Bruce L.

    2012-01-01

    Student engagement in classroom activities is usually described as a function of factors such as human needs, affect, intention, motivation, interests, identity, and others. We take a different approach and develop a framework that models classroom engagement as a function of students' "conceptual competence" in the "specific content" (e.g., the…

  12. Student Use of Facebook for Organizing Collaborative Classroom Activities

    ERIC Educational Resources Information Center

    Lampe, Cliff; Wohn, Donghee Yvette; Vitak, Jessica; Ellison, Nicole B.; Wash, Rick

    2011-01-01

    Social network sites such as Facebook are often conceived of as purely social spaces; however, as these sites have evolved, so have the ways in which students are using them. In this study, we examine how undergraduate students use the social network site Facebook to engage in classroom-related collaborative activities (e.g., arranging study…

  13. Predictors of Political Activism among Social Work Students

    ERIC Educational Resources Information Center

    Swank, Eric W.

    2012-01-01

    This article identifies factors inspiring greater political participation among undergraduate social work students (N=125). When separating students into self-identified liberals and conservatives, the study uses resource, mobilizing, and framing variables to explain greater levels of activism. After several multivariate regressions, this article…

  14. Economics and Entrepreneurship: Student Activities. Master Curriculum Guide.

    ERIC Educational Resources Information Center

    National Council on Economic Education, New York, NY.

    Correlated to the Economics and Entrepreneurship Teaching Strategies Master Curriculum Guide, this book features 66 student activities, case studies, comprehension quizzes, and lessons related to economic concepts. Designed for high school students of economics, social studies, and business education, this curriculum guide combines study of basic…

  15. Using the Web to Increase Physical Activity in College Students

    ERIC Educational Resources Information Center

    Magoc, Dejan; Tomaka, Joe; Bridges-Arzaga, Amber

    2011-01-01

    Objectives: To evaluate the effectiveness of a theoretically based and Web-delivered intervention using common course technology for increasing physical activity in a college student sample. Methods: One hundred four students randomly participated in either a Web-based intervention involving 7 theory-based learning lessons or a control group that…

  16. Student Activity and Learning Outcomes in a Virtual Learning Environment

    ERIC Educational Resources Information Center

    Romanov, Kalle; Nevgi, Anne

    2008-01-01

    The aim of the study was to explore the relationship between degree of participation and learning outcomes in an e-learning course on medical informatics. Overall activity in using course materials and degree of participation in the discussion forums of an online course were studied among 39 medical students. Students were able to utilise the…

  17. Design for Diversity: A Program Planning Grid for Student Activities.

    ERIC Educational Resources Information Center

    Kubik, Jan B.

    This guide provides a program planning grid for college student personnel workers involved in the area of student activities. A program planning and evaluative system is proposed to address campus needs and allow greater control in planning an educationally balanced program. This system is based on an outline of topical areas to be addressed…

  18. Effects of Teacher Professional Learning Activities on Student Achievement Growth

    ERIC Educational Resources Information Center

    Akiba, Motoko; Liang, Guodong

    2016-01-01

    The authors examined the effects of six types of teacher professional learning activities on student achievement growth over 4 years using statewide longitudinal survey data collected from 467 middle school mathematics teachers in 91 schools merged with 11,192 middle school students' mathematics scores in a standardized assessment in Missouri. The…

  19. Students' Learning Activities While Studying Biological Process Diagrams

    ERIC Educational Resources Information Center

    Kragten, Marco; Admiraal, Wilfried; Rijlaarsdam, Gert

    2015-01-01

    Process diagrams describe how a system functions (e.g. photosynthesis) and are an important type of representation in Biology education. In the present study, we examined students' learning activities while studying process diagrams, related to their resulting comprehension of these diagrams. Each student completed three learning tasks. Verbal…

  20. Intercultural Orientation Activities for International ESL Students: 50 Module Lessons.

    ERIC Educational Resources Information Center

    Villarreal, Linda

    Fifty modules are presented for increasing the cultural and linguistic fluency of English-as-a-Second-Language (ESL) students by integrating cultural awareness activities with language practice. The modules are intended for international students at an intermediate language level; they can, however, be used or adapted for beginning or advanced…

  1. Services for Older Adults. Reference Book [and] Student Activity Book.

    ERIC Educational Resources Information Center

    Texas Tech Univ., Lubbock. Curriculum Center for Family and Consumer Sciences.

    This student activity book and reference book, which are part of a family and consumer sciences education series focusing on a broad range of employment opportunities, are intended for use in 1- and 2- programs preparing Texas high school students for employment in occupations related to providing services for older adults. The reference book…

  2. An Aging Game Simulation Activity for Allied Health Students

    ERIC Educational Resources Information Center

    Douglass, Carolinda; Henry, Beverly W.; Kostiwa, Irene M.

    2008-01-01

    The Aging Game, a simulation activity, has been used successfully with medical students in the development of empathetic attitudes toward older adults. To date, the Aging Game has not been used extensively with allied health students. It has been viewed as too costly, time-consuming and labor-intensive. The purpose of this study was to examine the…

  3. A Study of Leadership Styles that Lead to Academic Achievement of Hispanic Students

    ERIC Educational Resources Information Center

    Smith, Mitzi Harris

    2010-01-01

    The purpose of this study was to determine the relationship between secondary principal leadership style and Hispanic student achievement. Student achievement was measured by the graduation rate for each school. The principals' leadership styles were defined by scores in the Leadership Orientations Profile. The online survey was sent to 549…

  4. Facebook as a Tool for Learning Purposes: Analysis of the Determinants Leading to Improved Students' Learning

    ERIC Educational Resources Information Center

    Nkhoma, Mathews; Cong, Hiep Pham; Au, Bill; Lam, Tri; Richardson, Joan; Smith, Ross; El-Den, Jamal

    2015-01-01

    The study described in this article aims to investigate the use of out-of-class communication between students and instructors using Facebook as a means of interaction for learning. How often/how much students use such an online social network and the clarification as to the reasons for online communication are the two exogenous variables used to…

  5. Student Success Centers: Leading the Charge for Change at Community Colleges

    ERIC Educational Resources Information Center

    Smith, Caroline Altman; Baldwin, Christopher; Schmidt, Gretchen

    2015-01-01

    Ten years ago, community college presidents' most valued datum was the number of students enrolled, which drove the colleges' funding. Providing access to higher education for the millions of students without the time, money, or academic preparation to attend a traditional four-year college was (as it always had been) their top priority. Today, a…

  6. Are University Students Really Customers? When Illusion May Lead to Delusion for All!

    ERIC Educational Resources Information Center

    Svensson, Goran; Wood, Greg

    2007-01-01

    Purpose: The marketing concept is an idea that has been adopted in non-marketing contexts, such as the relationships between universities and their students. This paper aims to posit that marketing metaphors are inappropriate to describe the student-university relationship. Design/methodology/approach: The authors provide a conceptual discussion…

  7. Exploring What Leads High School Students to Enroll in Hispanic-Serving Institutions: A Multilevel Analysis

    ERIC Educational Resources Information Center

    Nunez, Anne-Marie; Bowers, Alex J.

    2011-01-01

    This study examined the student and high school contextual factors associated with high school students' enrollment in Hispanic-Serving Institutions (HSIs). The authors drew on a conceptual framework of college choice involving the concepts of multiple capitals and individual and organizational habitus to examine the postsecondary trajectories of…

  8. Student Leadership Characteristics Leading to Success in an Online Community College Program

    ERIC Educational Resources Information Center

    Waters, Elsa G.

    2012-01-01

    This study was an effort to fill a gap in the research about why there are higher drop-out rates for students in online classrooms than students in traditional classrooms. Educators and administrators at online higher education institutions need information with which to address drop-out rates because the decreased number of completed online…

  9. Where Will They Lead? MBA Student Attitudes about Business & Society. Executive Summary.

    ERIC Educational Resources Information Center

    Aspen Inst., Queenstown, MD.

    This survey was conducted through the Internet to study the effects of a Master's in Business Administration (MBA) on students' attitudes about the roles and responsibilities of business. The survey was conducted in 3 waves: (1) August/September 1999, capturing the responses of 1,116 MBA students as they entered business school; (2) spring 2000,…

  10. Leading Learning: Enhancing the Learning Experience of University Students through Anxiety Auditing

    ERIC Educational Resources Information Center

    Maringe, Felix

    2010-01-01

    This article reports on an innovative strategy for auditing university students' anxieties across the study cycle. It discusses the shortcomings of traditional feedback mechanisms and identifies the opportunities that anxiety auditing presents in terms of providing scope for students to discuss and to more directly influence improvement in course…

  11. δ-Aminolevulinic acid dehydrase activity in the blood of men working with lead alkyls

    PubMed Central

    Millar, J. A.; Thompson, G. G.; Goldberg, A.; Barry, P. S. I.; Lowe, E. H.

    1972-01-01

    Millar, J. A., Thompson, G. G., Goldberg, A., Barry, P. S. I., and Lowe, E. H. (1972).Brit. J. industr. Med.,29, 317-320. δ-Aminolevulinic acid dehydrase activity in the blood of men working with lead alkyls. The activity of erythrocyte ALA1-dehydrase is inhibited in vivo at blood lead (Pb2+) levels within the upper range of normal (20-40 μg/100 ml) and in vitro at lead concentrations greater than 10-7 M. In view of the high sensitivity of the enzyme to Pb2+, the levels of enzyme activity in the blood of men occupationally exposed to lead alkyls, particularly tetraethyllead, were measured. It was found that the enzyme activity in an exposed group of men was significantly less (P<0·001) than in a control group, the respective mean values being 220 and 677 units of enzyme activity. Tetraethyllead is metabolized in the body via triethyllead and diethyllead ions. As the latter compound possesses properties similar to Pb2+, it was synthesized in the laboratory and its effect on ALA-dehydrase was studied. Diethyllead ion was found to inhibit ALA-dehydrase activity at concentrations greater than 5 x 10-5 M, although the degree of inhibition was less than that obtained with Pb2+. These results suggest that exposure to tetraethyllead can cause a decrease in erythrocyte ALA-dehydrase activity. PMID:5044603

  12. Negative relationships between erythrocyte Ca-pump activity and lead levels in mothers and newborns.

    PubMed

    Campagna, D; Huel, G; Hellier, G; Girard, F; Sahuquillo, J; Fagot-Campagna, A; Godin, J; Blot, P

    2000-12-01

    Lead poisoning induces hematological, gastrointestinal and neurological dysfunctions. One of the potential mechanisms is the inhibition of calcium-pump (Ca-pump), a transport protein. We investigated the effects of an environmental low lead exposure on Ca-pump activity in 247 mothers and their newborns. Maternal and cord blood, and newborn and mother hair, were sampled at delivery. Geometric means for mother and cord blood lead (Pb-B), and for mother and newborn hair lead (Pb-H), were 6.3 and 4.8 microg/dl, and 1.7 and 1.1 microg/g. Means for mother and cord basal Ca-pump activities were 2,442 and 2,675 nM/mg/hr. Mother enzymatic activity was negatively related to her Pb-B and Pb-H and to the cord Pb-B and newborn Pb-H levels. Newborn enzymatic activity was negatively related to his Pb-H level only. Adjustment for gestational age, child's sex, mother's age at delivery, alcohol, coffee and tea consumption, and smoking habits during pregnancy did not modify these relationships. Our findings support the hypothesis that lead toxicity could be in part mediated by a reduction of Ca-pump activity. This effect could be observed at low environmental exposure, in mothers and newborns. PMID:11191638

  13. Outdoor Education Activities for Elementary School Students.

    ERIC Educational Resources Information Center

    Lee, Connie L.

    Outdoor education is an informal method of teaching and learning which offers opportunities for elementary school students, regardless of intellectual abilities, to learn about and appreciate their environment and acquire skills with which to enjoy a lifetime of creative, productive, and healthful living. Outdoor education can enrich, vitalize,…

  14. Building on Student Diversity: Profiles and Activities

    ERIC Educational Resources Information Center

    Cowdery, Joy R.; Rogness, Linda Ingling; Morrow, Linda E.; Wilson, Vicki A.

    2006-01-01

    This text captures the profiles and cumulative records of six diverse students at early childhood, middle childhood, and then high school level. Intended for the preservice teacher, this book illustrates how to create a caring school environment; accommodate for special learning needs in instructional and assessments; and interact with families…

  15. Magnetism and Electricity Activity "Attracts" Student Interest

    ERIC Educational Resources Information Center

    Roman, Harry T.

    2010-01-01

    Electricity and magnetism are intimately linked, this relationship forming the basis of the modern electric utility system and the generation of bulk electrical energy. There is rich literature from which to teach students the basics, but nothing drives the point home like having them learn from firsthand experience--and that is what this…

  16. Enhancing Active Learning in the Student Laboratory

    ERIC Educational Resources Information Center

    Modell, Harold I.; Michael, Joel A.; Adamson, Tom; Horwitz, Barbara

    2004-01-01

    We previously examined how three approaches to directing students in a laboratory setting impacted their ability to repair a faulty mental model in respiratory physiology (Modell, HI, Michael JA, Adamson T, Goldberg J, Horwitz BA, Bruce DS, Hudson ML, Whitescarver SA, and Williams S. Adv Physiol Educ 23: 82?90, 2000). This study addresses issues…

  17. Students as Active Historians. Spotlight Feature

    ERIC Educational Resources Information Center

    Dopke-Wilson, MariRae

    2006-01-01

    Coming up with interesting information literacy lessons can be challenging for the high school librarian. If school librarians have taught their upper class students well, most are prepared to navigate their way successfully through libraries and Internet resources. In this article, the author explores a unique high school project that resulted in…

  18. Saving Tropical Rain Forests through Teacher-Student Activism.

    ERIC Educational Resources Information Center

    Calhoun, Bruce

    1990-01-01

    Described are the formation, goals, and activities of a network of teachers and students designed to help raise consciousness about conservation topics. A two-week minicourse on tropical diversity, ecology, and society is outlined. (CW)

  19. Problem-Centered and Experimental Mathematics Activities for Aboriginal Students.

    ERIC Educational Resources Information Center

    Seputro, Theresia Tirta

    1998-01-01

    Presents an activity carried out by aboriginal students that addresses solving a real-life problem that could be linked to number sequence, graph theory, and combinations. Contains 14 references. (ASK)

  20. Learning Activities: Students and Recycling. [and] Automobile Aerodynamics.

    ERIC Educational Resources Information Center

    McLaughlin, Charles H., Jr.; Schieber, Rich

    1994-01-01

    The first learning activity is intended to heighten students' awareness of the need for recycling, reuse, and reduction of materials; the second explores the aerodynamics of automobiles. Both include context, concept, objectives, procedure, and materials needed. (SK)

  1. Activated Sludge. Student Manual. Biological Treatment Process Control.

    ERIC Educational Resources Information Center

    Boe, Owen K.; Klopping, Paul H.

    This student manual contains the textual material for a seven-lesson unit on activated sludge. Topic areas addressed in the lessons include: (1) activated sludge concepts and components (including aeration tanks, aeration systems, clarifiers, and sludge pumping systems); (2) activated sludge variations and modes; (3) biological nature of activated…

  2. Research experience in Maine leads to teacher and student success in Texas

    NASA Astrophysics Data System (ADS)

    Slade-Redden, D.; Incze, L.; Census Of Marine Life-Maine

    2010-12-01

    As a High School science teacher it is my responsibility to present curriculum, to create enthusiasm for science, and to instill a passion and love for science in my students. Through a research experience as an ARMADA master teacher my passion and enthusiasm for the ocean was rekindled in the Gulf of Maine. Topics I had taught for years came alive in front of my eyes, and I was able to experience science to its fullest. I brought home many photographs, valuable information, and new enthusiasm to my students. I began a program called S.A.N.D. (Students As Nature Directors). In this program my students teach 3rd graders about the oceans and its many wonders. Also, I have incorporated hands-on research based projects. The research experience has enabled my students to become more scientifically literate and capable of sharing scientific knowledge with others. This presentation will show how research/teacher partnerships benefit students as well as teachers and how my students and district have benefited from my experience as an ARMADA master teacher. Author: Debra Slade-Redden Author #2: Lew Incze

  3. Mastery inspired activities to help at risk students

    NASA Astrophysics Data System (ADS)

    Stelzer, Tim; Gladding, Gary; Gutmann, Brianne; Lundsgaard, Morten; Schroeder, Noah

    2016-03-01

    Introductory physics is a roadblock for many aspiring engineers at the University of Illinois. The overall attrition rate in our introductory mechanics and E&M courses is approximately 15%, however that rate doubles for some under-represented populations. We introduced a set of online activities designed to provide students both an accurate assessment of their current understanding, and the resources to improve their performance. This talk will describe the design of these activities, and their impact on student attitude and understanding.

  4. Developing and evaluating effective bioscience learning activities for nursing students.

    PubMed

    Salvage-Jones, Judith; Hamill, Jessie; Todorovic, Michael; Barton, Matthew J; Johnston, Amy N B

    2016-07-01

    Effective engagement of nursing students in the study of biosciences remains a challenge for many tertiary institutes. In this study we attempted to implement and then evaluate a simple hands-on intervention, consisting of a series of hands-on games and puzzles, to increase nursing student engagement with core concepts and anatomical learning involved in clinical anatomy and physiology. The study used a quazi-experimental longitudinal before and after design, to explore the effect of a learning intervention on student performance. Set across three different campuses of the same University, it included 1320 first year undergraduate nursing students from 2013 to 2014 who were studying Anatomy and Physiology. Students were exposed to the interventions or not, and concomitant academic performance, weekly quiz scores, performance in fortnightly worksheets and, across the semester, exam performance were compared. The results show that while the intervention appeared to increase academic performance in students on one campus (2013) compared to the other two, this difference was not sustained into 2014 when a bigger cohort was examined. Despite significant subjective student satisfaction and enthusiasm about these learning and teaching interventions, the data does not support the capacity of these activities to enhance student academic performance. Tertiary entrance scores, being a non-native English speakers and socio-economic status all had a bigger impact on student performance than engagement with fun anatomy and physiology activities. PMID:27428695

  5. URI's ARMADA Research Experience Leads to Inspiring Middle School Students to Become Ocean Stewards

    NASA Astrophysics Data System (ADS)

    Barrett, M.

    2010-12-01

    After spending three weeks aboard NOAA’s David Starr Jordon, my classroom has come alive with ocean life. My research experience was part of URI’s ARMADA project. I worked alongside scientists as they conducted ‘business as usual’ on the CSCAPE expedition. CSCAPE’s mission was to survey the cetacean abundance in the Pacific Ocean. My leg of the voyage took us as far out as 300 nautical miles from the coast and from points between Newport, Oregon and San Francisco, California. Throughout the three weeks, I learned with the best of them how cetaceans are identified, photographed, counted, and biopsied. This 2005 research experience is still with me today in the classroom. I have created a “Bring the Sea to Me” program in which my middle school students teach elementary students about ocean life. My students also use video footage and photographs from my expedition to create wildlife documentaries shown at our annual Film Festival. My students have also worked with engineering students from a local university to create a life-size fin whale, which travels with us on our teaching trips, and I have since purchased a 100-gallon touch tank to give the students a hands-on experience with the organisms we collect while seining along the New Jersey coast. The science I learned while on the Jordan has allowed me to teach my students how cetaceans are surveyed, how to identify cetaceans by their blows and dorsal fins, and how to identify individuals within a species. Survey graphs are interpreted and conclusions are drawn. The students also see the importance of writing in science when they explore my journals from the expedition (www.armadaproject.org/journals/2005-2006/barrett/barrett-8-21.htm). My participation in CSCAPE inspired me beyond belief, and I can only hope that my enthusiasm for the ocean is inspiring students to become stewards of our oceans.

  6. Removal of Lead (II) Ions from Aqueous Solutions onto Activated Carbon Derived from Waste Biomass

    PubMed Central

    Erdem, Murat; Ucar, Suat; Karagöz, Selhan; Tay, Turgay

    2013-01-01

    The removal of lead (II) ions from aqueous solutions was carried out using an activated carbon prepared from a waste biomass. The effects of various parameters such as pH, contact time, initial concentration of lead (II) ions, and temperature on the adsorption process were investigated. Energy Dispersive X-Ray Spectroscopy (EDS) analysis after adsorption reveals the accumulation of lead (II) ions onto activated carbon. The Langmuir and Freundlich isotherm models were applied to analyze equilibrium data. The maximum monolayer adsorption capacity of activated carbon was found to be 476.2 mg g−1. The kinetic data were evaluated and the pseudo-second-order equation provided the best correlation. Thermodynamic parameters suggest that the adsorption process is endothermic and spontaneous. PMID:23853528

  7. Student Behavior and Epistemological Framing: Examples from Collaborative Active-Learning Activities in Physics

    ERIC Educational Resources Information Center

    Scherr, Rachel E.; Hammer, David

    2009-01-01

    The concept of framing from anthropology and sociolinguistics is useful for understanding student reasoning. For example, a student may frame a learning activity as an opportunity for sensemaking or as an assignment to fill out a worksheet. The student's framing affects what she notices, what knowledge she accesses, and how she thinks to act. We…

  8. Students' Performance in Investigative Activity and Their Understanding of Activity Aims

    ERIC Educational Resources Information Center

    Gomes, Alessandro Damasio Trani; Borges, A. Tarciso; Justi, Rosaria

    2008-01-01

    This study investigates the relationship between the students' understanding of the aims of an investigative activity and their performance when conducting it. One hundred and eighty-one year nine students from a public middle school in Brazil took part in the study. Students working in pairs were asked to investigate two problems using a…

  9. Measuring Students' Physical Activity Levels: Validating SOFIT for Use with High-School Students

    ERIC Educational Resources Information Center

    van der Mars, Hans; Rowe, Paul J.; Schuldheisz, Joel M.; Fox, Susan

    2004-01-01

    This study was conducted to validate the System for Observing Fitness Instruction Time (SOFIT) for measuring physical activity levels of high-school students. Thirty-five students (21 girls and 14 boys from grades 9-12) completed a standardized protocol including lying, sitting, standing, walking, running, curl-ups, and push-ups. Heart rates and…

  10. Using Sales Management Students to Manage Professional Selling Students in an Innovative Active Learning Project

    ERIC Educational Resources Information Center

    Young, Joyce A.; Hawes, Jon M.

    2013-01-01

    This paper describes an application of active learning within two different courses: professional selling and sales management. Students assumed the roles of sales representatives and sales managers for an actual fund-raiser--a golf outing--sponsored by a student chapter of the American Marketing Association. The sales project encompassed an…

  11. Classroom Environment and Student Outcomes among Students Using Anthropometry Activities in High-School Science

    ERIC Educational Resources Information Center

    Lightburn, Millard E.; Fraser, Barry J.

    2007-01-01

    The main purpose of this research was to evaluate the use of anthropometric activities among a sample of 761 high-school biology students in terms of student outcomes (achievement and attitudes) and classroom environment (assessed with the Science Laboratory Environment Inventory, SLEI). Data analyses supported the SLEI's factorial validity,…

  12. Moderate Levels of Activation Lead to Forgetting In the Think/No-Think Paradigm

    PubMed Central

    Detre, Greg J.; Natarajan, Annamalai; Gershman, Samuel J.; Norman, Kenneth A.

    2013-01-01

    Using the think/no-think paradigm (Anderson & Green, 2001), researchers have found that suppressing retrieval of a memory (in the presence of a strong retrieval cue) can make it harder to retrieve that memory on a subsequent test. This effect has been replicated numerous times, but the size of the effect is highly variable. Also, it is unclear from a neural mechanistic standpoint why preventing recall of a memory now should impair your ability to recall that memory later. Here, we address both of these puzzles using the idea, derived from computational modeling and studies of synaptic plasticity, that the function relating memory activation to learning is U-shaped, such that moderate levels of memory activation lead to weakening of the memory and higher levels of activation lead to strengthening. According to this view, forgetting effects in the think/no-think paradigm occur when the suppressed item activates moderately during the suppression attempt, leading to weakening; the effect is variable because sometimes the suppressed item activates strongly (leading to strengthening) and sometimes it does not activate at all (in which case no learning takes place). To test this hypothesis, we ran a think/no-think experiment where participants learned word-picture pairs; we used pattern classifiers, applied to fMRI data, to measure how strongly the picture associates were activating when participants were trying not to retrieve these associates, and we used a novel Bayesian curve-fitting procedure to relate this covert neural measure of retrieval to performance on a later memory test. In keeping with our hypothesis, the curve-fitting procedure revealed a nonmonotonic relationship between memory activation (as measured by the classifier) and subsequent memory, whereby moderate levels of activation of the to-be-suppressed item led to diminished performance on the final memory test, and higher levels of activation led to enhanced performance on the final test. PMID:23499722

  13. Motivational activities based on previous knowledge of students

    NASA Astrophysics Data System (ADS)

    García, J. A.; Gómez-Robledo, L.; Huertas, R.; Perales, F. J.

    2014-07-01

    Academic results depend strongly on the individual circumstances of students: background, motivation and aptitude. We think that academic activities conducted to increase motivation must be tuned to the special situation of the students. Main goal of this work is analyze the students in the first year of the Degree in Optics and Optometry in the University of Granada and the suitability of an activity designed for those students. Initial data were obtained from a survey inquiring about the reasons to choose this degree, their knowledge of it, and previous academic backgrounds. Results show that: 1) the group is quite heterogeneous, since students have very different background. 2) Reasons to choose the Degree in Optics and Optometry are also very different, and in many cases were selected as a second option. 3) Knowledge and motivations about the Degree are in general quite low. Trying to increase the motivation of the students we designed an academic activity in which we show different topics studied in the Degree. Results show that students that have been involved in this activity are the most motivated and most satisfied with their election of the degree.

  14. Correlates of Student Political Activism and Ideology

    ERIC Educational Resources Information Center

    Lewis, Steven H.; Kraut, Robert E.

    1972-01-01

    Yale freshmen were classified into four ideology groupings and two levels of activism. The absence of significant interactions and the concordance of some correlates of activism and ideology are discussed. (DM)

  15. The Relationship of Participation in Extracurricular Activities to Student Achievement, Student Attendance, and Student Behavior in a Nebraska School District

    ERIC Educational Resources Information Center

    Dick, Andrew D.

    2010-01-01

    The purpose of this study was to examine possible relationships between participation in extracurricular activities and student achievement, participation in extracurricular activities and attendance, and participation in extracurricular activities and behavior. The setting for this study was a high school in western Nebraska. Data for 275 of the…

  16. Revisiting the question: Does high-latitude solar activity lead low-latitude solar activity in time phase?

    SciTech Connect

    Kong, D. F.; Qu, Z. N.; Guo, Q. L.

    2014-05-01

    Cross-correlation analysis and wavelet transform methods are used to investigate whether high-latitude solar activity leads low-latitude solar activity in time phase or not, using the data of the Carte Synoptique solar filaments archive from 1919 March to 1989 December. From the cross-correlation analysis, high-latitude solar filaments have a time lead of 12 Carrington solar rotations with respect to low-latitude ones. Both the cross-wavelet transform and wavelet coherence indicate that high-latitude solar filaments lead low-latitude ones in time phase. Furthermore, low-latitude solar activity is better correlated with high-latitude solar activity of the previous cycle than with that of the following cycle, which is statistically significant. Thus, the present study confirms that high-latitude solar activity in the polar regions is indeed better correlated with the low-latitude solar activity of the following cycle than with that of the previous cycle, namely, leading in time phase.

  17. Student Constructions of "Active Citizenship": What Does Participation Mean to Students?

    ERIC Educational Resources Information Center

    Kennedy, Kerry J.

    2007-01-01

    "Active citizenship" is currently a popular term in citizenship education policy discourse. Despite this policy interest, there is no agreement about the meaning of "active citizenship". This article draws on data from the IEA Civic Education Study to explore how students themselves construct "active citizenship". The results show that students…

  18. Activities of the Student Forum of the Geoinformation Forum Japan

    NASA Astrophysics Data System (ADS)

    Oba, A.; Miyazaki, H.

    2012-07-01

    This reports a history and future prospects of the activities by the Student Forum of the Geoinformation Forum Japan. For growths of academic fields, active communications among students and young scientists are indispensable. Several academic communities in geoinformation fields are established by youths and play important roles of building networks over schools and institutes. The networks are expected to be innovative cooperation after the youths achieve their professions. Although academic communities are getting fixed growth particularly in Japan, youths had gotten little opportunities to make contacts with youths themselves. To promote gotten youth activities among geoinformation fields, in 1998, we started a series of programs that named the Student Forum of the Geoinformation Forum Japan involving students and young scientists within the annual conferences, Geoinformation Forum Japan. The programs have provided opportunities to do presentation their studies by posters, some events, and motivations to create networks among students and young scientists. From 2009, some members of our activities set additional conference in west area of Japan. Thus our activities are spread within Japan. As a result of these achievements, the number of youth dedicating to the programs keeps growing. From 2009, it's getting international gradually, however, almost all the participants are still Japanese. To keep and expand the network, we are planning to make some nodes with some Asian youth organizations in the field of geoinformation. This paper is concluded with proposals and future prospects on the Student Forum of the Geoinformation Forum Japan.

  19. A long-term, prospective, cohort study on the performance of right ventricular pacing leads: comparison of active-fixation with passive-fixation leads.

    PubMed

    Liu, Lie; Tang, Jiaojiao; Peng, Hu; Wu, Shulin; Lin, Chunying; Chen, Dongli; Zhang, Qianhuan; Liang, Yuanhong; Chen, Silin; Chen, Yan; Wei, Huiqiang

    2015-01-01

    Active-fixation pacing leads allow the use of selective pacing sites. We evaluated their long-term performance versus passive-fixation leads in 199 newly implanted patients (n = 100 active and n = 99 passive). Postoperative pacing thresholds in the active group were higher than in the passive group (0.85 ± 0.31 V vs. 0.53 ± 0.21 V at baseline, P < 0.001). The active thresholds fell to 0.72 ± 0.23 V at 5 years with a significant drop at one month (0.68 ± 0.53 V, P = 0.003). The passive thresholds slightly increased to 0.72 ± 0.31 V at five years. Differences between groups were significant until three years (all P < 0.05). Active impedances were generally lower than passive impedances (600.44 ± 94.31Ω vs. 683.14 ± 110.98Ω at baseline), and both showed significant reductions at one month to 537.96 ± 147.43Ω in the active group, and after three months to 643.85 ± 82.40Ω in the passive group (both P < 0.01 vs. baseline). Impedance differences between groups were significant until four years (all P < 0.05). Adverse events included thresholds over 1 V, 5 of 6 active and 2 of 5 passive leads returned to below 1 V. One active left ventricular lead dislodged. One passive left subclavian lead insulation fracture occurred. Thus Active fixation pacing leads are stable in a five-year long-term follow up. There was no difference between active and passive leads in terms of electrical performance. PMID:25563218

  20. Evaluation of trace trace elements iron, zinc, copper and lead in the diet of female university students.

    PubMed

    Hashim, Z; Abdhamid, R

    1995-03-01

    Food consumption of 50 female students in Universiti Kebangsaan Malaysia was recorded for 7 days. Foods and drinks most frequently consumed were selected for analysis of iron, zinc, copper and lead content. The mean daily intakes of energy, protein, carbohydrate and fat among the students are 6.5±1.4 MJ (1550±335 kcal), 59.8±18.5g, 227.1±54.6 g and 46.0±11.5 g respectively. This diet contributed 19.6-6.4 mg Fe, 7.0-2.0 mg Zn and 1.6-0.6 mg Cu per day which were lower than the Malaysian RDA for Fe and US RDA for Zn, while Cu is within the recommended range. The main sources of these minerals in the student's diet were rice, rice products, meat and animal products. Lead concentration in the diet (134±77 ug/day) is below the acceptable daily intake (ADI) value suggested by Codex Alimentarius Commission (1984). This study indicated concern regarding the low intake of the essential trace elements on long term basis among the students. PMID:22692012

  1. Student leadership and activism for social change in the US.

    PubMed

    Grande, D; Srinivas, S

    2001-01-01

    As the US health-care system continues on a path toward greater patient and provider dissatisfaction and decreasing access to primary health services, there is a growing need for leadership among tomorrow's health professionals. Students of today must acquire the skills to lead the United States toward solutions that will offer universal access and eliminate disparities. As examined in the US, there are two main modes for students to learn these meaningful skills; curriculum- and institution-based leadership development and organization-based leadership development. In this paper we review these two methods from an American perspective and discuss ways that educational institutions can support student leadership development. In addition, we address ways in which non-governmental organizations can provide opportunities to foster student leadership. Lastly, we offer recommendations for US policy change at institutional, local, state, and national levels to help achieve the goals stated above. PMID:14742018

  2. Cardiovascular Disease and Cancer: Student Awareness Activities.

    ERIC Educational Resources Information Center

    Meyer, James H., Comp.

    Awareness activities pertaining to cancer and cardiovascular disease are presented as a supplement for high school science classes. The exercises can be used to enrich units of study dealing with the circulatory system, the cell, or human diseases. Eight activities deal with the following topics: (1) cardiovascular disease risk factors; (2)…

  3. Groundwater: A Vital Resource. Student Activities.

    ERIC Educational Resources Information Center

    Taylor, Carla, Ed.

    Twenty-three activities dealing with various aspects of groundwater are provided in this manual. The activities are arranged under four headings: (1) the water cycle; (2) water distribution in soils (considering such topics as calculating water table depth and purifying water by filtering); (3) water quality (considering such topics as acid rain,…

  4. Evaluation of lead exposure in workers at secondary lead smelters in South Korea: with focus on activity of erythrocyte pyrimidine 5'-nucleotidase (P5N).

    PubMed

    Kim, Yangho; Lee, Hun; Lee, Choong Ryed; Park, Dong Uk; Yang, Jeong Sun; Park, In Jeong; Lee, Kwang Yong; Lee, MiYoung; Kim, Tae-Kyun; Sohn, Nam-Seok; Cho, Young Sook; Lee, NaRoo; Chung, Ho Keun

    2002-03-01

    To evaluate lead exposure among secondary lead-smelting workers with a focus on erythrocyte pyrimidine 5'-nucleotidase (P5N) activity, blood lead concentration (PbB), activity of P5N and other biological variables were examined in 88 exposed workers in five secondary lead smelters and in 24 non-exposed workers in Korea. All of the mean values of air lead concentration (PbA) in the three processes, scrap pretreatment, blast furnace smelting, and refining and casting of the secondary lead smelters, markedly exceeded 0.05 mg/m3. In this survey, 29 (97%) of 30 air samples for lead exceeded 0.05 mg/m3. The highest mean PbA and PbB values were found in the section of blast furnace smelting. All of the mean PbB values in all the sections were higher than 30 microg/dl. PbB of 71 (81%) of the 88 exposed workers exceeded 30 microg/dl. In 31 (35%) of the exposed workers, PbB was above 60 microg/dl. Compared with the non-exposed group, zinc protoporphyrin (ZPP) in the exposed group was significantly increased, whereas erythrocyte P5N activity and activity of erythrocyte delta-aminolevulinic acid dehydratase (ALAD) were significantly inhibited. Erythrocyte P5N activity had valid biological correlation with PbB and with other biological variables, such as ALAD activity or ZPP. Lead exposure affected hemoglobin levels via inhibition of P5N activity, as well as the heme biosynthetic pathway, in the high-exposure state. PMID:11886093

  5. The analysis and reconciliation of students' rebuttals in argumentation activities

    NASA Astrophysics Data System (ADS)

    Lin, Yu-Ren; Hung, Jeng-Fung

    2016-01-01

    The present study investigated the guidance provided by science teachers to resolve conflicts during socioscientific issue-based argumentation activities. A graphical representation (GR) was developed as a tool to code and analyze the dialogue interaction process. Through the GR and qualitative analysis, we identified three types of dialogue reconciling strategies. The first one consists of teacher management, in which the teacher temporarily maintains the right to speak when students get mired in an emotional rebuttal situation. The second strategy involves the use of qualifiers to identify the strengths and weaknesses of an opposing argument. The third strategy consists of providing students with guidance to keep both parties (i.e. the students taking, respectively, the affirmative and negative positions) on the same discussion topic and can be used to assist teachers with forming broad questions that prompt students to conduct deeper discussions. These reconciling strategies were beneficial in that they helped students to argue in a more reflective way.

  6. Graduate Nursing Students' Attitudes Toward Sexually Active Older Persons.

    ERIC Educational Resources Information Center

    Damrosch, Shirley Petchel

    1984-01-01

    Reviewed empirical evidence relevant to taboos for aged sexuality and measured the attitudes of 114 graduate nursing students toward a 68-year-old woman. Nurses read a vignette which either contained or excluded information about the woman's sexual activity and exhibited a statistically significant bias favoring the sexually active version. (JAC)

  7. Correlates of School-Day Physical Activity in Preschool Students

    ERIC Educational Resources Information Center

    Robinson, Leah E.; Wadsworth, Danielle D.; Peoples, Christina M.

    2012-01-01

    This study examined the relationship among sex, body mass index, motor skill competence (MSC), perceived physical competence (PPC), and school-day physical activity in preschool students (N = 34). Physical activity was assessed by steps accumulated during the school day, while MSC and PPC were assessed with the Test of Gross Motor Development--2nd…

  8. Drama Activities that Promote and Extend Your Students' Vocabulary Proficiency.

    ERIC Educational Resources Information Center

    Alber, Sheila R.; Foil, Carolyn R.

    2003-01-01

    This article suggests using drama activities to teach target vocabulary words to students with limited vocabulary development. It presents specific drama activities to implement when introducing new vocabulary, conducting guided practice, facilitating cooperative learning groups, and assigning independent practice. Suggestions are also offered for…

  9. Breaking the Ice: Career Development Activities for Accounting Students

    ERIC Educational Resources Information Center

    Kilpatrick, Bob G.; Wilburn, Nancy L.

    2010-01-01

    This paper describes two co-curricular career development activities, mock interviews and speed networking that we provide for accounting majors at our university. The driving force behind both activities was to increase comfort levels for students when interacting with professionals and to enhance their job interview and networking skills.…

  10. Factors Shaping Students' Opportunities to Engage in Argumentative Activity

    ERIC Educational Resources Information Center

    Ayalon, Michal; Even, Ruhama

    2016-01-01

    This study examines how students' opportunities to engage in argumentative activity are shaped by the teacher, the class, and the mathematical topic. It compares the argumentative activity between two classes taught by the same teacher using the same textbook and across two beginning algebra topics--investigating algebraic expressions and…

  11. Engaging Students in Qualitative Research through Experiential Class Activities.

    ERIC Educational Resources Information Center

    Fontes, Lisa Aronson; Piercy, Fred P.

    2000-01-01

    Discusses the experiential activities that are used in a graduate course on qualitative research that addresses focus groups, observation, data collection, cultural sensitivity, ethnomethodology, data analysis, and morals and ethics in research. Explains that students participate in an activity in which they defend qualitative research. (CMK)

  12. Career Orientation 7-8. Student Activity Sheets in Economics.

    ERIC Educational Resources Information Center

    Flowers, E. L.

    Activity sheets for seventh and eighth grade student use in economics are contained in this document. Activities are developed in the following areas: checking accounts, bank account applications, check writing, keeping a check register, using checks, budgets, insurance, responsibility and planning, consumer shopping, supermarkets, taxes, help…

  13. Drinking Water Activities for Students, Teachers, and Parents.

    ERIC Educational Resources Information Center

    Environmental Protection Agency, Washington, DC.

    This guide provides teachers with materials, information, and classroom activities to enhance any drinking water curriculum. Students can use the activity sheets to further lessons and stimulate thought. Parents can use the guide to develop science projects that will provoke thought, encourage research, and provide a scientific approach to…

  14. The Draws and Drawbacks of College Students' Active Procrastination

    ERIC Educational Resources Information Center

    Hensley, Lauren C.

    2016-01-01

    When students procrastinate, they divert time from academics toward other activities, returning to academics at a later time. Active procrastination is a departure from the form of procrastination defined by scholars as passive (i.e., avoidant, maladaptive) in nature. Hensley selected the methodology (phenomenology) in order to undertake an…

  15. Multimedia Activities for Students: A Teachers' and Librarians' Handbook.

    ERIC Educational Resources Information Center

    Sorrow, Barbara Head

    This book is a collection of multimedia ideas and activities for use in classrooms and libraries. Each activity is intended to be adaptable and for use in many subject areas and for a wide range of age groups. The book emphasizes the creative learning of the student, programs, and available resources. Six chapters are as follows: (1)…

  16. 25 CFR 36.43 - Standard XVI-Student activities.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... CFR 31.7. All student activity accounts shall be audited annually. (h) The school shall provide for...-recognized leagues will abide by those state rules regulating inter-school competition. (d) Until comparable... activities shall be required to have qualified sponsors and be approved by the school supervisor, and...

  17. 25 CFR 36.43 - Standard XVI-Student activities.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... CFR 31.7. All student activity accounts shall be audited annually. (h) The school shall provide for...-recognized leagues will abide by those state rules regulating inter-school competition. (d) Until comparable... activities shall be required to have qualified sponsors and be approved by the school supervisor, and...

  18. 25 CFR 36.43 - Standard XVI-Student activities.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... CFR 31.7. All student activity accounts shall be audited annually. (h) The school shall provide for...-recognized leagues will abide by those state rules regulating inter-school competition. (d) Until comparable... activities shall be required to have qualified sponsors and be approved by the school supervisor, and...

  19. 25 CFR 36.43 - Standard XVI-Student activities.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... CFR 31.7. All student activity accounts shall be audited annually. (h) The school shall provide for...-recognized leagues will abide by those state rules regulating inter-school competition. (d) Until comparable... activities shall be required to have qualified sponsors and be approved by the school supervisor, and...

  20. Peer Listening in the Middle School: Training Activities for Students.

    ERIC Educational Resources Information Center

    Hazouri, Sandra Peyser; Smith, Miriam Frey

    This workbook presents activities for training middle school student peer listeners. The first of the workbook's 10 chapters contains an introduction to peer listening. Activities include a pretest on a series of true-false statements called the "Peer Listening Inventory," defining the meaning of the words that describe the qualities of a peer…

  1. Physical Activity & Sport for the Secondary School Student. Fifth Edition.

    ERIC Educational Resources Information Center

    Dougherty, Neil J., Ed.

    This collection of papers offers a comprehensive text about contemporary physical activities and sports forms. It provides students with an overview of the various physical activities, skill technique required, safety, scoring, rules and etiquette, strategies, equipment, and related terminology. The 26 papers are: (1) "Physical Fitness" (Carolyn…

  2. Students Speak With Angela Bauer, Facilities Operations and Maintenance Group Lead

    NASA Video Gallery

    From NASA’s International Space Station Mission Control Center Angela Bauer, Facilities Operations and Maintenance Group lead in the Mission Operations Directorate at Johnson Space Center, partic...

  3. Characteristics Leading to Student Success: A Study of Online Learning Environments

    ERIC Educational Resources Information Center

    Crawford, Deborah L.

    2006-01-01

    Background: Virtual learning has exploded with the growth in broadband connectivity. The challenge for today's educational leaders is to integrate the research indicating cognitive changes in today's students with online K-12 offerings in order to fully maximize technological advances and close access and academic gaps. Purpose: To inform both…

  4. Power of Place: Emerging Science Programs Help Tribal College Students Lead the Way--At Home

    ERIC Educational Resources Information Center

    Zaffos, Joshua

    2013-01-01

    Since the first tribal college was established in the late 1960s, tribal colleges and universities have offered technical-learning opportunities to students in isolated communities around the country. From the onset, many of these colleges focused on providing practical skills and vocational job training, and frequently targeted nontraditional,…

  5. The Student-Centered Active Learning Environment for Undergraduate Programs (SCALE-UP) Project

    NASA Astrophysics Data System (ADS)

    Beichner, Robert J.

    2011-04-01

    How do you keep a classroom of 100 undergraduates actively learning? Can students practice communication and teamwork skills in a large class? How do you boost the performance of underrepresented groups? The Student-Centered Active Learning Environment for Undergraduate Programs (SCALE-UP) Project has addressed these concerns. Because of their inclusion in a leading introductory physics textbook, project materials are used by more than 1/3 of all science, math, and engineering majors nationwide. The room design and pedagogy have been adopted at more than 100 leading institutions across the country. Physics, chemistry, math, astronomy, biology, engineering, earth sciences, and even literature classes are currently being taught this way. Educational research indicates that students should collaborate on interesting tasks and be deeply involved with the material they are studying. We promote active learning in a redesigned classroom for 100 students or more. (Of course, smaller classes can also benefit.) Class time is spent primarily on "tangibles" and "ponderables"--hands-on activities, simulations, and interesting questions. Nine students sit in three teams at round tables. Instructors circulate and engage in Socratic dialogues. The setting looks like a banquet hall, with lively interactions nearly all the time. Hundreds of hours of classroom video and audio recordings, transcripts of numerous interviews and focus groups, data from conceptual learning assessments (using widely-recognized instruments in a pretest/posttest protocol), and collected portfolios of student work are part of our rigorous assessment effort. Our findings (based on data from over 16,000 students collected over five years as well as replications at adopting sites) can be summarized as the following: 1) Female failure rate is 1/5 of previous levels, even though more is demanded of students. 2) Minority failure rate is 1/4 that seen in traditionally taught courses. 3) At-risk students are more

  6. Expansion of student activities in Africa: from south to north

    NASA Astrophysics Data System (ADS)

    Cherif, Rim; Ben Salem, Amine; Gueddana, Amor; Zghal, Mourad; Naidoo, Darryl; Forbes, Andrew; Heidt, Alexander M.; Rohwer, Erich G.

    2014-07-01

    Optics and photonics research in Africa has gradually grown in the past ten years with a very active optical community involved in state-of-the-art research. Despite relatively low resources, optics research in the continent is competitive with many international benchmarks and has had a significant impact within the African continent. In the past five years, a group of dynamic students have developed the student chapter network from Tunisia to South Africa. The first student chapters of the optical society of America (OSA) and the international society for optics and photonics (SPIE) were established in South Africa (in the Council for Scientific and Industrial Research (CSIR) and in the University of Stellenbosch), followed by a chapter in Tunisia (Engineering school of communications of Tunis, Sup'Com). In this paper, we will present the major activities of the student chapters of Tunisia and South Africa, and how they are promoting optics and photonics in Africa.

  7. UNESCO active learning approach in optics and photonics leads to significant change in Morocco

    NASA Astrophysics Data System (ADS)

    Berrada, K.; Channa, R.; Outzourhit, A.; Azizan, M.; Oueriagli, A.

    2014-07-01

    There are many difficulties in teaching science and technology in developing countries. Several different teaching strategies have to be applied in these cases. More specifically, for developing countries competencies in teaching science in the introductory classroom has attracted much attention. As a specific example we will consider the Moroccan system. In most developing countries everything is moving so slowly that the progress stays static for development. Also, any change needs time, effort and engagement. In our case we discovered that many teachers feel uncomfortable when introducing new teaching methods and evaluation in classes at introductory physics. However, the introduction of an Active Learning in our curricula showed difficulties that students have in understanding physics and especially concepts. Students were interested in having Active Learning courses much more than passive and traditional ones. Changing believes on physical phenomena and reality of the world students become more attractive and their way of thinking Science changed. The main philosophy of fostering modern hands-on learning techniques -adapted to local needs and availability of teaching resources- is elaborated. The Active Learning program provides the teachers with a conceptual evaluation instrument, drawn from relevant physics education research, giving teachers an important tool to measure student learning. We will try to describe the UNESCO Chair project in physics created in 2010 at Cadi Ayyad University since our first experience with UNESCO ALOP program. Many efforts have been done so far and the project helps now to develop more national and international collaborations between universities and Regional Academies of Education and Training. As a new result of these actions and according to our local needs, the translation of the ALOP program into Arabic is now available under the auspice of UNESCO and encouragement of international partners SPIE, ICTP, ICO and OSA.

  8. Microbial activity, arbuscular mycorrhizal fungi and inoculation of woody plants in lead contaminated soil.

    PubMed

    Gattai, Graziella S; Pereira, Sônia V; Costa, Cynthia M C; Lima, Cláudia E P; Maia, Leonor C

    2011-07-01

    The goals of this study were to evaluate the microbial activity, arbuscular mycorrhizal fungi and inoculation of woody plants (Caesalpinia ferrea, Mimosa tenuiflora and Erythrina velutina) in lead contaminated soil from the semi-arid region of northeastern of Brazil (Belo Jardim, Pernambuco). Dilutions were prepared by adding lead contaminated soil (270 mg Kg(-1)) to uncontaminated soil (37 mg Pb Kg soil(-1)) in the proportions of 7.5%, 15%, and 30% (v:v). The increase of lead contamination in the soil negatively influenced the amount of carbon in the microbial biomass of the samples from both the dry and rainy seasons and the metabolic quotient only differed between the collection seasons in the 30% contaminated soil. The average value of the acid phosphatase activity in the dry season was 2.3 times higher than observed during the rainy season. There was no significant difference in the number of glomerospores observed between soils and periods studied. The most probable number of infective propagules was reduced for both seasons due to the excess lead in soil. The mycorrhizal colonization rate was reduced for the three plant species assayed. The inoculation with arbuscular mycorrhizal fungi benefited the growth of Erythrina velutina in lead contaminated soil. PMID:24031701

  9. Microbial activity, arbuscular mycorrhizal fungi and inoculation of woody plants in lead contaminated soil

    PubMed Central

    Gattai, Graziella S.; Pereira, Sônia V.; Costa, Cynthia M. C.; Lima, Cláudia E. P.; Maia, Leonor C.

    2011-01-01

    The goals of this study were to evaluate the microbial activity, arbuscular mycorrhizal fungi and inoculation of woody plants (Caesalpinia ferrea, Mimosa tenuiflora and Erythrina velutina) in lead contaminated soil from the semi-arid region of northeastern of Brazil (Belo Jardim, Pernambuco). Dilutions were prepared by adding lead contaminated soil (270 mg Kg-1) to uncontaminated soil (37 mg Pb Kg soil-1) in the proportions of 7.5%, 15%, and 30% (v:v). The increase of lead contamination in the soil negatively influenced the amount of carbon in the microbial biomass of the samples from both the dry and rainy seasons and the metabolic quotient only differed between the collection seasons in the 30% contaminated soil. The average value of the acid phosphatase activity in the dry season was 2.3 times higher than observed during the rainy season. There was no significant difference in the number of glomerospores observed between soils and periods studied. The most probable number of infective propagules was reduced for both seasons due to the excess lead in soil. The mycorrhizal colonization rate was reduced for the three plant species assayed. The inoculation with arbuscular mycorrhizal fungi benefited the growth of Erythrina velutina in lead contaminated soil. PMID:24031701

  10. Development of a Laboratory Project to Determine Human ABO Genotypes--Limitations Lead to Further Student Explorations

    ERIC Educational Resources Information Center

    Salerno, Theresa A.

    2009-01-01

    A multiplex allele-specific PCR analysis was developed to identify six "common" genotypes: AA, AO, BB, BO, OO, and AB. This project included a pre-laboratory exercise that provided active learning experiences and developed critical thinking skills. This laboratory resulted in many successful analyses, which were verified by student knowledge of…

  11. [Effects of automobile lead on the general growth and sexual activity of the rat].

    PubMed

    el Feki, A; Ghorbel, F; Smaoui, M; Makni-Ayadi, F; Kammoun, A

    2000-01-01

    To identify the active element of automotive exhaust gas responsible for masculine infertility, previously proved by our laboratory, we undertook these experiments. Four hundred young male and female rats were exposed during two months (30 min/d) to three types of automotive exhaust gases. The first type emanated from an engine running on gasoline with lead, the second from an unleaded gasoline engine, the third from a diesel engine. These three engines had the same power (5 horsepower vehicles < 3.5 tons). For the first type of emissions, some lead deposits were found in the lungs by histologic techniques. This gas also induced in male rats the atrophy of the testicle, seminal vesicle and epididym, certain pathological changes in spermatogenesis shown by the histologic study, and a decrease of the serum's testosterone level. In female rats, the relative weights of the ovary and uterus, as well as the percentage of the arrival of oestrus, were not affected by the gaseous treatment. Both the second and third types of gases seemed less active on the masculine sex as far as these parameters are concerned. Our study suggests that, for light vehicles, leaded gasoline pollutes more than unleaded gasoline or diesel fuels, and that the lead present only in the first type would be the active element responsible for the masculine infertility and body weight gain reduction in rats. PMID:10774118

  12. Human health risk assessment of lead from mining activities at semi-arid locations in the context of total lead exposure.

    PubMed

    Zheng, Jiajia; Huynh, Trang; Gasparon, Massimo; Ng, Jack; Noller, Barry

    2013-12-01

    Lead from historical mining and mineral processing activities may pose potential human health risks if materials with high concentrations of bioavailable lead minerals are released to the environment. Since the Joint Expert Committee on Food Additives of Food and Agriculture Organization/World Health Organization withdrew the Provisional Tolerable Weekly Intake of lead in 2011, an alternative method was required for lead exposure assessment. This study evaluated the potential lead hazard to young children (0-7 years) from a historical mining location at a semi-arid area using the U.S. EPA Integrated Exposure Uptake Biokinetic (IEUBK) Model, with selected site-specific input data. This study assessed lead exposure via the inhalation pathway for children living in a location affected by lead mining activities and with specific reference to semi-arid conditions and made comparison with the ingestion pathway by using the physiologically based extraction test for gastro-intestinal simulation. Sensitivity analysis for major IEUBK input parameters was conducted. Three groups of input parameters were classified according to the results of predicted blood concentrations. The modelled lead absorption attributed to the inhalation route was lower than 2 % (mean ± SE, 0.9 % ± 0.1 %) of all lead intake routes and was demonstrated as a less significant exposure pathway to children's blood, compared with ingestion. Whilst dermal exposure was negligible, diet and ingestion of soil and dust were the dominant parameters in terms of children's blood lead prediction. The exposure assessment identified the changing role of dietary intake when house lead loadings varied. Recommendations were also made to conduct comprehensive site-specific human health risk assessment in future studies of lead exposure under a semi-arid climate. PMID:24122159

  13. Lead Poisoning

    MedlinePlus

    Lead is a metal that occurs naturally in the earth's crust. Lead can be found in all parts of our ... from human activities such as mining and manufacturing. Lead used to be in paint; older houses may ...

  14. Increased concanavalin A-induced suppressor cell activity in humans with occupational lead exposure

    SciTech Connect

    Cohen, N.; Modai, D.; Golik, A.; Weissgarten, J.; Peller, S.; Katz, A.; Averbukh, Z.; Shaked, U.

    1989-02-01

    E-rosette-forming cells (E-RFC), mitogen-induced blast transformation, OKT4+, OKT8+ cells, and their ratio were found to be normal in 10 subjects chronically exposed to lead with blood levels of 40-51 micrograms%. However, concanavalin A (Con A)-induced suppressor cell activity (SCA) in these subjects was significantly greater than in normal matched controls. The clinical relevance of this observation is not clear, but it may have some bearing on the various immunologic defects described in lead exposure.

  15. Effects of Lead Exposure and Genetic Polymorphisms on ALAD and GPx Activities in Brazilian Battery Workers.

    PubMed

    da Cunha Martins, Airton; Mazzaron Barcelos, Gustavo Rafael; Jacob Ferreira, Anna Laura Bechara; de Souza, Marilesia Ferreira; de Syllos Cólus, Ilce Mara; Antunes, Lusânia Maria Greggi; Bastos Paoliello, Monica Maria; Adeyemi, Joseph A; Barbosa, Fernando

    2015-01-01

    Lead (Pb) is a toxic metal that is widely used by metallurgical industries such as car battery recycling. Exposure to the metal may modify the redox status of the cells and consequently result in changes in activities of important enzymes such as delta-aminolevulinic acid dehydratase (ALAD) and glutathione peroxidase (GPx). Similarly, genetic polymorphisms may modulate the activities of enzymes related to detoxification processes of the metal and may modify Pb body burden. Therefore, the aims of the present study were (i) to evaluate the correlation between blood lead levels (BLL) and activities of the enzymes ALAD and GPx, and (ii) to determine whether activities of these enzymes may be influenced by polymorphisms in ALAD and GPx genes in Brazilian automotive battery workers chronically exposed to Pb, as well as the effects of these polymorphisms on BLL. Our study included 257 participants; BLL were determined by inductively couple plasma-mass spectrometry (ICP-MS), and the activities of the enzymes ALAD and GPx were quantified spectrophotometrically; and genotyping of ALAD (rs1800435) and GPx-1 (rs1800668) polymorphisms was performed by TaqMan assays (real-time polymerase chain reaction, RT-PCR). Significant negative correlations were found between BLL and ALAD activity. Subjects who carried at least one polymorphic allele for ALAD gene displayed markedly lower ALAD activities, while no significant effect was observed regarding GPx-1 polymorphism and activity of the same enzyme. Further, ALAD and GPx-1 polymorphisms exerted no marked influence on BLL. Taken together, our results showed that BLL affected ALAD but not GPx activities, and these were not modulated by polymorphisms in ALAD and GPx gene. Further, the rs1800435 SNP showed a tendency to modulate ALAD activity, while the rs1800668 SNP did not modulate GPx activity in Brazilian automotive battery workers exposed to Pb. PMID:26275098

  16. Physical Activity and Student Performance at School.

    ERIC Educational Resources Information Center

    Taras, Howard

    2005-01-01

    To review the state of research on the association between physical activity among school-aged children and academic outcomes, the author reviewed published studies on this topic. A table includes brief descriptions of each study's research methodology and outcomes. A review of the research demonstrates that there may be some short-term…

  17. Understanding Interactions between Manganese Oxide and Gold That Lead to Enhanced Activity for Electrocatalytic Water Oxidation

    PubMed Central

    2015-01-01

    To develop active nonprecious metal-based electrocatalysts for the oxygen evolution reaction (OER), a limiting reaction in several emerging renewable energy technologies, a deeper understanding of the activity of the first row transition metal oxides is needed. Previous studies of these catalysts have reported conflicting results on the influence of noble metal supports on the OER activity of the transition metal oxides. Our study aims to clarify the interactions between a transition metal oxide catalyst and its metal support in turning over this reaction. To achieve this goal, we examine a catalytic system comprising nanoparticulate Au, a common electrocatalytic support, and nanoparticulate MnOx, a promising OER catalyst. We conclusively demonstrate that adding Au to MnOx significantly enhances OER activity relative to MnOx in the absence of Au, producing an order of magnitude higher turnover frequency (TOF) than the TOF of the best pure MnOx catalysts reported to date. We also provide evidence that it is a local rather than bulk interaction between Au and MnOx that leads to the observed enhancement in the OER activity. Engineering improvements in nonprecious metal-based catalysts by the addition of Au or other noble metals could still represent a scalable catalyst as even trace amounts of Au are shown to lead a significant enhancement in the OER activity of MnOx. PMID:24661269

  18. Understanding interactions between manganese oxide and gold that lead to enhanced activity for electrocatalytic water oxidation.

    PubMed

    Gorlin, Yelena; Chung, Chia-Jung; Benck, Jesse D; Nordlund, Dennis; Seitz, Linsey; Weng, Tsu-Chien; Sokaras, Dimosthenis; Clemens, Bruce M; Jaramillo, Thomas F

    2014-04-01

    To develop active nonprecious metal-based electrocatalysts for the oxygen evolution reaction (OER), a limiting reaction in several emerging renewable energy technologies, a deeper understanding of the activity of the first row transition metal oxides is needed. Previous studies of these catalysts have reported conflicting results on the influence of noble metal supports on the OER activity of the transition metal oxides. Our study aims to clarify the interactions between a transition metal oxide catalyst and its metal support in turning over this reaction. To achieve this goal, we examine a catalytic system comprising nanoparticulate Au, a common electrocatalytic support, and nanoparticulate MnO(x), a promising OER catalyst. We conclusively demonstrate that adding Au to MnO(x) significantly enhances OER activity relative to MnO(x) in the absence of Au, producing an order of magnitude higher turnover frequency (TOF) than the TOF of the best pure MnO(x) catalysts reported to date. We also provide evidence that it is a local rather than bulk interaction between Au and MnO(x) that leads to the observed enhancement in the OER activity. Engineering improvements in nonprecious metal-based catalysts by the addition of Au or other noble metals could still represent a scalable catalyst as even trace amounts of Au are shown to lead a significant enhancement in the OER activity of MnO(x). PMID:24661269

  19. Describing Changes in Undergraduate Students' Preconceptions of Research Activities

    NASA Astrophysics Data System (ADS)

    Cartrette, David P.; Melroe-Lehrman, Bethany M.

    2012-12-01

    Research has shown that students bring naïve scientific conceptions to learning situations which are often incongruous with accepted scientific explanations. These preconceptions are frequently determined to be misconceptions; consequentially instructors spend time to remedy these beliefs and bring students' understanding of scientific concepts to acceptable levels. It is reasonable to assume that students also maintain preconceptions about the processes of authentic scientific research and its associated activities. This study describes the most commonly held preconceptions of authentic research activities among students with little or no previous research experience. Seventeen undergraduate science majors who participated in a ten week research program discussed, at various times during the program, their preconceptions of research and how these ideas changed as a result of direct participation in authentic research activities. The preconceptions included the belief that authentic research is a solitary activity which most closely resembles the type of activity associated with laboratory courses in the undergraduate curriculum. Participants' views showed slight maturation over the research program; they came to understand that authentic research is a detail-oriented activity which is rarely successfully completed alone. These findings and their implications for the teaching and research communities are discussed in the article.

  20. Prevalence and patterns of physical activity among medical students in Bangalore, India

    PubMed Central

    Padmapriya, Krishnakumar; Krishna, Pushpa; Rasu, Thenna

    2013-01-01

    Background: Physical activity is one of the leading health indicators. The objective was to study the prevalence and patterns of physical activity among young adults. Methods: 259 Medical students (Men: Women = 116:143) in the age group of 18–22 yrs were interviewed using the official English long version of the International Physical Activity Questionnaire (IPAQ). The total level of physical activity and activity in each of the 4 life domains – work, transport, domestic and gardening and leisure-time were estimated and was expressed as metabolic equivalent-hours per week (MET-hour/week). Results: 41.3 % showed high levels of physical activity, 43.2% and 15.4 % of students showed moderate level and low level of physical activity respectively. 84.6 % (n=219) were engaged in work related activity and 80.7% (n= 209) showed transport related activity. Domestic and gardening physical activity represented 63.7 % (n=165) of individuals total activity and 67.2% of students showed leisure time activity. The average time spent in sitting was 7.06 hrs/day. The median of the total physical activity for the whole sample was 39.13 MET/hour/week and 18.10 for work, 4.40 for transportation, 2.60 for domestic and gardening and 4 for leisure-time activity. There was significant gender difference observed with women having low physical activity. Conclusion: This study provides baseline information about the physical activity levels and patterns including sitting hours among Indian young adults using IPAQ that can used for comparison of data across different parts of world. PMID:26120390

  1. Helping Graduate Teaching Assistants Lead Discussions with Undergraduate Students: A Few Simple Teaching Strategies

    ERIC Educational Resources Information Center

    Jensen, Murray; Farrand, Kirsten; Redman, Leanne; Varcoe, Tamara; Coleman, Leana

    2005-01-01

    Graduate Teaching Assistants (GTAs) are frequently asked to lead discussion groups. These groups generally take the form of tutorials, review sessions, or problem-based learning classes. In their preparation, what to teach is often emphasized over how to teach. The primary intent of this article is to provide a few simple teaching strategies for…

  2. High Throughput Screening Identifies Novel Lead Compounds with Activity against Larval, Juvenile and Adult Schistosoma mansoni.

    PubMed

    Mansour, Nuha R; Paveley, Ross; Gardner, J Mark F; Bell, Andrew S; Parkinson, Tanya; Bickle, Quentin

    2016-04-01

    An estimated 600 million people are affected by the helminth disease schistosomiasis caused by parasites of the genus Schistosoma. There is currently only one drug recommended for treating schistosomiasis, praziquantel (PZQ), which is effective against adult worms but not against the juvenile stage. In an attempt to identify improved drugs for treating the disease, we have carried out high throughput screening of a number of small molecule libraries with the aim of identifying lead compounds with balanced activity against all life stages of Schistosoma. A total of almost 300,000 compounds were screened using a high throughput assay based on motility of worm larvae and image analysis of assay plates. Hits were screened against juvenile and adult worms to identify broadly active compounds and against a mammalian cell line to assess cytotoxicity. A number of compounds were identified as promising leads for further chemical optimization. PMID:27128493

  3. High Throughput Screening Identifies Novel Lead Compounds with Activity against Larval, Juvenile and Adult Schistosoma mansoni

    PubMed Central

    Gardner, J. Mark F.; Bell, Andrew S.; Parkinson, Tanya; Bickle, Quentin

    2016-01-01

    An estimated 600 million people are affected by the helminth disease schistosomiasis caused by parasites of the genus Schistosoma. There is currently only one drug recommended for treating schistosomiasis, praziquantel (PZQ), which is effective against adult worms but not against the juvenile stage. In an attempt to identify improved drugs for treating the disease, we have carried out high throughput screening of a number of small molecule libraries with the aim of identifying lead compounds with balanced activity against all life stages of Schistosoma. A total of almost 300,000 compounds were screened using a high throughput assay based on motility of worm larvae and image analysis of assay plates. Hits were screened against juvenile and adult worms to identify broadly active compounds and against a mammalian cell line to assess cytotoxicity. A number of compounds were identified as promising leads for further chemical optimization. PMID:27128493

  4. How Active Are Your Students? Increasing Physical Activity in Schools

    ERIC Educational Resources Information Center

    Avery, Marybell; Brandt, Janet

    2010-01-01

    The U. S. Department of Health and Human Services recommends that youth engage in at least 60 minutes of physical activity each day, most of which should be either moderate- or vigorous-intensity aerobic physical activity. Half of this amount (30 minutes) should be achieved during the school day. NASPE provides guidance in the form of a…

  5. Novel Series of Potent Glucokinase Activators Leading to the Discovery of AM-2394.

    PubMed

    Dransfield, Paul J; Pattaropong, Vatee; Lai, Sujen; Fu, Zice; Kohn, Todd J; Du, Xiaohui; Cheng, Alan; Xiong, Yumei; Komorowski, Renee; Jin, Lixia; Conn, Marion; Tien, Eric; DeWolf, Walter E; Hinklin, Ronald J; Aicher, Thomas D; Kraser, Christopher F; Boyd, Steven A; Voegtli, Walter C; Condroski, Kevin R; Veniant-Ellison, Murielle; Medina, Julio C; Houze, Jonathan; Coward, Peter

    2016-07-14

    Glucokinase (GK) catalyzes the phosphorylation of glucose to glucose-6-phosphate. We present the structure-activity relationships leading to the discovery of AM-2394, a structurally distinct GKA. AM-2394 activates GK with an EC50 of 60 nM, increases the affinity of GK for glucose by approximately 10-fold, exhibits moderate clearance and good oral bioavailability in multiple animal models, and lowers glucose excursion following an oral glucose tolerance test in an ob/ob mouse model of diabetes. PMID:27437083

  6. Failure of origin activation in response to fork stalling leads to chromosomal instability at fragile sites.

    PubMed

    Ozeri-Galai, Efrat; Lebofsky, Ronald; Rahat, Ayelet; Bester, Assaf C; Bensimon, Aaron; Kerem, Batsheva

    2011-07-01

    Perturbed DNA replication in early stages of cancer development induces chromosomal instability preferentially at fragile sites. However, the molecular basis for this instability is unknown. Here, we show that even under normal growth conditions, replication fork progression along the fragile site, FRA16C, is slow and forks frequently stall at AT-rich sequences, leading to activation of additional origins to enable replication completion. Under mild replication stress, the frequency of stalling at AT-rich sequences is further increased. Strikingly, unlike in the entire genome, in the FRA16C region additional origins are not activated, suggesting that all potential origins are already activated under normal conditions. Thus, the basis for FRA16C fragility is replication fork stalling at AT-rich sequences and inability to activate additional origins under replication stress. Our results provide a mechanism explaining the replication stress sensitivity of fragile sites and thus, the basis for genomic instability during early stages of cancer development. PMID:21726815

  7. Epilepsy-Related Slack Channel Mutants Lead to Channel Over-Activity by Two Different Mechanisms.

    PubMed

    Tang, Qiong-Yao; Zhang, Fei-Fei; Xu, Jie; Wang, Ran; Chen, Jian; Logothetis, Diomedes E; Zhang, Zhe

    2016-01-01

    Twelve sodium-activated potassium channel (KCNT1, Slack) genetic mutants have been identified from severe early-onset epilepsy patients. The changes in biophysical properties of these mutants and the underlying mechanisms causing disease remain elusive. Here, we report that seven of the 12 mutations increase, whereas one mutation decreases, the channel's sodium sensitivity. Two of the mutants exhibit channel over-activity only when the intracellular Na(+) ([Na(+)]i) concentration is ∼80 mM. In contrast, single-channel data reveal that all 12 mutants increase the maximal open probability (Po). We conclude that these mutant channels lead to channel over-activity predominantly by increasing the ability of sodium binding to activate the channel, which is indicated by its maximal Po. The sodium sensitivity of these epilepsy causing mutants probably determines the [Na(+)]i concentration at which these mutants exert their pathological effects. PMID:26725113

  8. 77 FR 16796 - Lead Requirements for Lead-Based Paint Activities in Target Housing and Child-Occupied Facilities...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-22

    ... listings at http://www.gpoaccess.gov/fr/ . 2. In person: The State submittal is also available for public... of submission, which was March 29, 1999. (See, 64 FR 27266, May 19, 1999). In 2011, the Arkansas... activities program. On August 29, 1996 (61 FR 45777) (FRL-5389-9), EPA promulgated final TSCA section...

  9. Active learning increases student performance in science, engineering, and mathematics.

    PubMed

    Freeman, Scott; Eddy, Sarah L; McDonough, Miles; Smith, Michelle K; Okoroafor, Nnadozie; Jordt, Hannah; Wenderoth, Mary Pat

    2014-06-10

    To test the hypothesis that lecturing maximizes learning and course performance, we metaanalyzed 225 studies that reported data on examination scores or failure rates when comparing student performance in undergraduate science, technology, engineering, and mathematics (STEM) courses under traditional lecturing versus active learning. The effect sizes indicate that on average, student performance on examinations and concept inventories increased by 0.47 SDs under active learning (n = 158 studies), and that the odds ratio for failing was 1.95 under traditional lecturing (n = 67 studies). These results indicate that average examination scores improved by about 6% in active learning sections, and that students in classes with traditional lecturing were 1.5 times more likely to fail than were students in classes with active learning. Heterogeneity analyses indicated that both results hold across the STEM disciplines, that active learning increases scores on concept inventories more than on course examinations, and that active learning appears effective across all class sizes--although the greatest effects are in small (n ≤ 50) classes. Trim and fill analyses and fail-safe n calculations suggest that the results are not due to publication bias. The results also appear robust to variation in the methodological rigor of the included studies, based on the quality of controls over student quality and instructor identity. This is the largest and most comprehensive metaanalysis of undergraduate STEM education published to date. The results raise questions about the continued use of traditional lecturing as a control in research studies, and support active learning as the preferred, empirically validated teaching practice in regular classrooms. PMID:24821756

  10. Active learning increases student performance in science, engineering, and mathematics

    PubMed Central

    Freeman, Scott; Eddy, Sarah L.; McDonough, Miles; Smith, Michelle K.; Okoroafor, Nnadozie; Jordt, Hannah; Wenderoth, Mary Pat

    2014-01-01

    To test the hypothesis that lecturing maximizes learning and course performance, we metaanalyzed 225 studies that reported data on examination scores or failure rates when comparing student performance in undergraduate science, technology, engineering, and mathematics (STEM) courses under traditional lecturing versus active learning. The effect sizes indicate that on average, student performance on examinations and concept inventories increased by 0.47 SDs under active learning (n = 158 studies), and that the odds ratio for failing was 1.95 under traditional lecturing (n = 67 studies). These results indicate that average examination scores improved by about 6% in active learning sections, and that students in classes with traditional lecturing were 1.5 times more likely to fail than were students in classes with active learning. Heterogeneity analyses indicated that both results hold across the STEM disciplines, that active learning increases scores on concept inventories more than on course examinations, and that active learning appears effective across all class sizes—although the greatest effects are in small (n ≤ 50) classes. Trim and fill analyses and fail-safe n calculations suggest that the results are not due to publication bias. The results also appear robust to variation in the methodological rigor of the included studies, based on the quality of controls over student quality and instructor identity. This is the largest and most comprehensive metaanalysis of undergraduate STEM education published to date. The results raise questions about the continued use of traditional lecturing as a control in research studies, and support active learning as the preferred, empirically validated teaching practice in regular classrooms. PMID:24821756

  11. Collector attachment to lead-activated sphalerite - Experiments and DFT study on pH and solvent effects

    NASA Astrophysics Data System (ADS)

    Sarvaramini, A.; Larachi, F.; Hart, B.

    2016-03-01

    The interactions of diisobutyl dithiophosphinate with bare (un-activated) and lead-activated sphalerite were studied both experimentally and through DFT simulations. Sphalerite activated by lead in acidic and alkaline conditions showed considerably greater affinity for diisobutyl dithiophosphinate adsorption than bare sphalerite. Experimental observations supported by DFT simulations concur in that attachment of the solvated collector to the activated sphalerite surface is through adsorbed lead cations or lead hydroxides where as for the bare sphalerite, the collector was most stable in its solvated state and not as an adsorbed specie. Accounting for solvation effects by including a swarm of water molecules in DFT simulations was necessary to infer plausible surface interactions between collector, solvent, and bare or lead-activated sphalerite. The experimental data and DFT simulations indicate, affinity of the collector toward surface-adsorbed lead species was predicted to form stable covalent bonds between collector sulfur atoms and lead.

  12. Moving (Literally) to Engage Students: Putting the (Physically) Active in Active Learning

    ERIC Educational Resources Information Center

    Strean, William B.

    2010-01-01

    This paper explores a variety of practices and classroom activities that engage the whole student. Grounded in a somatic perspective (from "soma" meaning the body in its wholeness--the integration of thinking, feeling, and acting), the discussion shows how students can be brought fully into learning through movement, music, and…

  13. Gα12 Activation in Podocytes Leads to Cumulative Changes in Glomerular Collagen Expression, Proteinuria and Glomerulosclerosis

    PubMed Central

    Boucher, Ilene; Yu, Wanfeng; Beaudry, Sarah; Negoro, Hideyuki; Tran, Mei; Pollak, Martin; Henderson, Joel; Denker, Bradley M.

    2011-01-01

    Glomerulosclerosis is a common pathologic finding that often progresses to renal failure. The mechanisms of chronic kidney disease progression are not well-defined but may include activation of numerous vasoactive and inflammatory pathways. We hypothesized that podocytes are susceptible to filtered plasma components including hormones and growth factors that stimulate signaling pathways leading to glomerulosclerosis. Gα12 couples to numerous G-protein-coupled receptors (GPCR) and regulates multiple epithelial responses including proliferation, apoptosis, permeability and the actin cytoskeleton. Herein, we report that genetic activation of Gα12 in podocytes leads to time dependent increases in proteinuria and glomerulosclerosis. To mimic activation of Gα12-pathways, constitutively active Gα12(QL) was conditionally expressed in podocytes using Nphs2-Cre and LacZfloxed QLα12 transgenic mice. Some QLα12LacZ+/Cre+ mice developed proteinuria at 4-6m, and most were proteinuric by 12m. Proteinuria increased with age, and by 12-14m many demonstrated glomerulosclerosis with ultrastructural changes including foot process fusion and both mesangial and subendothelial deposits. QLα12LacZ+/Cre+ mice showed no changes in podocyte number, apoptosis, proliferation, or Rho/Src activation. Real-time PCR revealed no significant changes in Nphs1, Nphs2, Cd2ap, or Trpc6 expression, but Col4a2 message was increased in younger and older mice while Col4a5 was decreased in older mice. Confocal microscopy revealed disordered collagen IVα1/2 staining in older mice and loss of α5 without changes in other collagen IV subunits. Taken together, these studies suggest that Gα12 activation promotes glomerular injury without podocyte depletion through a novel mechanism regulating collagen (α)IV expression, and supports the notion that glomerular damage may accrue through persistent GPCR activation in podocytes. PMID:22249312

  14. Antifungal activities of Ocimum sanctum essential oil and its lead molecules.

    PubMed

    Khan, Amber; Ahmad, Aijaz; Manzoor, Nikhat; Khan, Luqman A

    2010-02-01

    Aqueous extracts and oils of five Indian medicinal plants, traditionally used for their antimicrobial activities, were evaluated against two of the most prevalent Candida species causing candidiasis, C. albicans and C. tropicalis. Of these plant materials, three showed varying degrees of antifungal activity against both species. Tulsi (Ocimum sanctum Linn.) essential oil (TEO) was found to be the most effective, followed by Peppermint essential oil, and Aloe vera aqueous leaf extract. The product with the lowest MIC was further studied along with its lead molecules to explore the possible mechanism of action of the most active constituents. Eugenol, methyl eugenol, linalool, and 1, 8-cineole, along with TEO were then evaluated at the same. The pattern and extent of inhibition was studied using growth and WST1 cytotoxicity assays. Proton pumps are important for growth and metabolism of Candida species and so H+ extrusion studies were performed to explore the possible mechanism of the test compounds. Linalool was the most active constituent of TEO, whereas inhibition of H+ extrusion appeared to be a synergistic function of the lead molecules. PMID:20334156

  15. A Longitudinal Study of Principals' Activities and Student Performance

    ERIC Educational Resources Information Center

    May, Henry; Huff, Jason; Goldring, Ellen

    2012-01-01

    Although a substantial amount of research on school leadership has focused on what principals may do to improve teaching and learning, little of this research has explored how principals' time spent on leadership activities may relate to and possibly affect student performance. This article presents results from a 3-year longitudinal study of…

  16. Office Reprographics. Instructor's Guide. Student Activity Packet. Office Occupations.

    ERIC Educational Resources Information Center

    Johnson, Diane E.

    This training package, one in a series of instructional modules consisting of an instructor's guide and a student activity packet, deals with office reprographics. Included in the instructor's guide are general directions for implementing the presentation; a detailed guide for teaching the lesson that includes performance objectives, suggestions…

  17. Nutrition Activities Guide for Students in Special Education: Citywide Programs.

    ERIC Educational Resources Information Center

    New York City Board of Education, Brooklyn, NY. Div. of Special Education.

    The guide is designed to provide special education students with nutrition education in terms of daily living skills. Activities are organized according to five themes: what we eat (awareness of the physical and sensory characteristics of food, identification of food eaten at various meals); how we eat (identification of cutlery, manners, use of…

  18. Performing Clerical Activities. Order Clerk. Student Manual and Instructor's Manual.

    ERIC Educational Resources Information Center

    Jones, Maleeta M.

    Supporting performance objectives 6 and 43 of the V-TECS (Vocational-Technical Education Consortium of States) Secretarial Catalog, both a set of student materials and an instructor's manual on preparing and processing requisitions are included in this packet. (The packet is the second in a set of three on performing clerical activities--CE 016…

  19. Performing Stenographic Activities. Compose Correspondence. Student's Manual and Instructor's Manual.

    ERIC Educational Resources Information Center

    Harrison, Pam

    Supporting performance objective 71 of the V-TECS (Vocational-Technical Education Consortium of States) Secretarial Catalog, both a set of student materials and an instructor's manual on composing correspondence are included in this packet. (The packet is the fourth in a set of four on performing stenographic activities--CE 016 973-976.) The…

  20. A Social Studies Activities Guide for Students in Special Education.

    ERIC Educational Resources Information Center

    New York City Board of Education, Brooklyn, NY. Div. of Special Education.

    The guide uses an activities-based approach to reinforce both social studies content and skills for special education elementary students. The guide has been designed to correspond with the scope and sequence of New York City's Minimum Teaching Essentials. Six themes are examined: (1) developing individuality and a sense of self (social/emotional…

  1. Getting Students Involved: Classroom Activities Which Promote Communication.

    ERIC Educational Resources Information Center

    Freeman, G. Ronald; And Others

    Three essays concerning second language classroom activities that promote learning of communication skills are presented. In "From Manipulation to Communication" (Renate A. Schulz), the importance of establishing minimal communicative objectives for classroom instruction skills is discussed, specifying situations in which students have to…

  2. Educating Pharmacy Students about Nutrition and Physical Activity Counseling

    ERIC Educational Resources Information Center

    Kotecki, Jerome E.; Clayton, Bruce D.

    2003-01-01

    The current study provides measures of association between self-reported beliefs of currently practicing pharmacists and pharmacy students' beliefs about, willingness to provide, and preparedness to provide counseling on nutrition and physical activity following completion of a health education unit. A 3-week health education unit focusing on the…

  3. Springboards into Holocaust: Five Activities for Secondary Social Studies Students.

    ERIC Educational Resources Information Center

    Allen, Rodney

    2000-01-01

    Explains that in a study of the Holocaust teachers must connect the stories of the Holocaust to the lives of their students. Provides five activities about the Holocaust that focus upon teaching tolerance. Addresses the children of the Holocaust, difference versus deviance, social identity, and The Night of Broken Glass. (CMK)

  4. Moodog: Tracking Student Activity in Online Course Management Systems

    ERIC Educational Resources Information Center

    Zhang, Hangjin; Almeroth, Kevin

    2010-01-01

    Many universities are currently using Course Management Systems (CMSes) to conduct online learning, for example, by distributing course materials or submitting homework assignments. However, most CMSes do not include comprehensive activity tracking and analysis capabilities. This paper describes a method to track students' online learning…

  5. Setting the Stage for Physical Activity for Secondary Students

    ERIC Educational Resources Information Center

    Ciccomascolo, Lori; Riebe, Deborah

    2006-01-01

    Despite the positive long-term physiological and psychological effects of exercise, many young adults between the ages of 12 and 21 years do not participate in regular physical activity. With the time constraints and other challenges in teaching and assessing students, physical educators need realistic strategies that will help in their efforts to…

  6. Active Geography: Engaging Students in Learning about Our World.

    ERIC Educational Resources Information Center

    Berkman, Patience; Eastman, Gloria; Merlau, Donna; Meisler, Susan; Miller, Barbara; Schukar, Ron; Singleton, Laurel R.; Thompson, Sara

    This set of lessons uses the six essential standards of "Geography for Life" as a basis. At least one lesson is provided for each standard and linked to one or more of the five fundamental themes of geography. At the end of each section is also a special active teaching feature to help students further focus on the concepts presented. The lessons…

  7. Student Activity Guide for "Business in an Information Economy."

    ERIC Educational Resources Information Center

    Graf, David; And Others

    The 20 chapters of this student activity guide provide study guides (key terms and concepts reviews), projects, cases for analyses, and self-assessment exercises for business and career education classes. Topics covered include the following: business winners (entrepreneurship); growth of the U.S. economy, the basics of economics, comparing…

  8. Satisfaction from Academic Activities among Medical Students in Malaysia

    ERIC Educational Resources Information Center

    Al-Naggar, Redhwan A.; Bobryshev, Yuri V.

    2013-01-01

    There is a lack of data about the levels of satisfaction among medical students in regards to their academic activities in Malaysia. Therefore, the objective of this study was to fill the gap in the existing knowledge. A cross sectional study was carried out at the International medical school, the Management and Science University of Malaysia,…

  9. Shaping Student Activists: Discursive Sensemaking of Activism and Participation Research

    ERIC Educational Resources Information Center

    Taha, Diane E.; Hastings, Sally O.; Minei, Elizabeth M.

    2015-01-01

    As social media becomes a more potent force in society, particularly for younger generations, the role in activism has been contested. This qualitative study examines 35 interviews with students regarding their perceptions of the use of social media in social change, their perceptions of activists, and their level of self-identification as an…

  10. Environmental Pollution, Student's Book (Experiences/Experiments/Activities).

    ERIC Educational Resources Information Center

    Weaver, Elbert C.

    Described in this student's manual are numerous experiments to acquaint the learner with community environmental problems. Experiments are relatively simple and useful in the junior high school grades. Activities are provided which emphasize some of the materials involved in pollution problems, such as carbon dioxide, sulfur compounds, and others,…

  11. Solar Energy Education. Industrial arts: student activities. Field test edition

    SciTech Connect

    Not Available

    1981-02-01

    In this teaching manual several activities are presented to introduce students to information on solar energy through classroom instruction. Wind power is also included. Instructions for constructing demonstration models for passive solar systems, photovoltaic cells, solar collectors and water heaters, and a bicycle wheel wind turbine are provided. (BCS)

  12. Behavioral Activation for Moderately Depressed University Students: Randomized Controlled Trial

    ERIC Educational Resources Information Center

    Gawrysiak, Michael; Nicholas, Christopher; Hopko, Derek R.

    2009-01-01

    Although depression is prevalent among university students, limited and dated research has examined the efficacy of behavioral interventions in treating this population (C. Lee, 2005). On the basis of a modified version of the Behavioral Activation Treatment for Depression (BATD; D. R. Hopko & C. W. Lejuez, 2007; C. W. Lejuez, D. R. Hopko, & S. D.…

  13. Another Way to Develop Chinese Students' Creativity: Extracurricular Innovation Activities

    ERIC Educational Resources Information Center

    Xiao-jiang, Zhao; Xue-ting, Zhao

    2012-01-01

    In China, improving students' creativity is becoming an important goal of modern colleges and universities, especially in the domain of science and technology. The efforts made for this goal can be observed not only in classroom, but also in activities and competitions which were held out-of-school. This paper will firstly give a brief description…

  14. Revealing Student Blogging Activities Using RSS Feeds and LMS Logs

    ERIC Educational Resources Information Center

    Derntl, Michael

    2010-01-01

    Blogs are an easy-to-use, free alternative to classic means of computer-mediated communication. Moreover, they are authentically aligned with web activity patterns of today's students. The body of studies on integrating and implementing blogs in various educational settings has grown rapidly recently; however, it is often difficult to distill…

  15. Coitally Active University Students: Sexual Behaviors, Concerns, and Challenges.

    ERIC Educational Resources Information Center

    Darling, Carol A.; Davidson, J. Kenneth., Sr.

    1986-01-01

    Examined behaviors, attitudes, and concerns of students coitally active. Differences between genders included male dissatisfaction with infrequent opportunities for sexual intercourse, lack of variety of sex partners, and insufficient oral-genital stimulation. Female concerns were lack of stimulation to their breasts, painful sexual intercourse,…

  16. Are Mandatory Student Activity Fees Really Mementos of the Past?

    ERIC Educational Resources Information Center

    Gibbs, Annette

    1999-01-01

    In the fall 1996 issue of this journal, Maxine Schmitz argued against the California Supreme Court's ruling in "Smith" that the University must provide a partial refund to students objecting to fees used for activities supporting a single political or ideological viewpoint. Annette Gibbs defends the "Smith" majority opinion. Perry Zirkel's…

  17. Solar Energy Education. Home economics: student activities. Field test edition

    SciTech Connect

    Not Available

    1981-03-01

    A view of solar energy from the standpoint of home economics is taken in this book of activities. Students are provided information on solar energy resources while performing these classroom activities. Instructions for the construction of a solar food dryer and a solar cooker are provided. Topics for study include window treatments, clothing, the history of solar energy, vitamins from the sun, and how to choose the correct solar home. (BCS)

  18. Triptolide activates unfolded protein response leading to chronic ER stress in pancreatic cancer cells

    PubMed Central

    Mujumdar, Nameeta; Banerjee, Sulagna; Chen, Zhiyu; Sangwan, Veena; Chugh, Rohit; Dudeja, Vikas; Yamamoto, Masato; Vickers, Selwyn M.

    2014-01-01

    Pancreatic cancer is a devastating disease with a survival rate of <5%. Moreover, pancreatic cancer aggressiveness is closely related to high levels of prosurvival mediators, which can ultimately lead to rapid disease progression. One of the mechanisms that enables tumor cells to evade cellular stress and promote unhindered proliferation is the endoplasmic reticulum (ER) stress response. Disturbances in the normal functions of the ER lead to an evolutionarily conserved cell stress response, the unfolded protein response (UPR). The UPR initially compensates for damage, but it eventually triggers cell death if ER dysfunction is severe or prolonged. Triptolide, a diterpene triepoxide, has been shown to be an effective compound against pancreatic cancer. Our results show that triptolide induces the UPR by activating the PKR-like ER kinase-eukaryotic initiation factor 2α axis and the inositol-requiring enzyme 1α-X-box-binding protein 1 axis of the UPR and leads to chronic ER stress in pancreatic cancer. Our results further show that glucose-regulated protein 78 (GRP78), one of the major regulators of ER stress, is downregulated by triptolide, leading to cell death by apoptosis in MIA PaCa-2 cells and autophagy in S2-VP10 cells. PMID:24699326

  19. Contemporary Student Activism Context as a Vehicle for Leader Identity Development

    ERIC Educational Resources Information Center

    Ivester, Stephen B.

    2013-01-01

    Contemporary college student activism efforts are growing. Little research has been conducted on student activism and leadership development. As student affairs educators consider leadership an important part of an undergraduate education it is important to consider how the context of activism actually influences student leader identity…

  20. Atrial electrical activity detection using linear combination of 12-lead ECG signals.

    PubMed

    Perlman, Or; Katz, Amos; Weissman, Noam; Amit, Guy; Zigel, Yaniv

    2014-04-01

    ECG analysis is the method for cardiac arrhythmia diagnosis. During the diagnostic process many features should be taken into consideration, such as regularity and atrial activity. Since in some arrhythmias, the atrial electrical activity (AEA) waves are hidden in other waves, and a precise classification from surface ECG is inapplicable, a confirmation diagnosis is usually performed during an invasive procedure. In this paper, we study a "semiautomatic" method for AEA-waves detection using a linear combination of 12-lead ECG signals. This method's objective is to be applicable to a variety of arrhythmias with emphasis given to detect concealed AEA waves. It includes two variations--using maximum energy ratio and a synthetic AEA signal. In the former variation, an energy ratio-based cost function is created and maximized using the gradient ascent method. The latter variation adapted the linear combiner method, when applied on a synthetic signal, combined with surface ECG leads. A study was performed evaluating the AEA-waves detection from 63 patients (nine training, 54 validation) presenting eight arrhythmia types. Averaged sensitivity of 92.21% and averaged precision of 92.08% were achieved compared to the definite diagnosis. In conclusion, the presented method may lead to early and accurate detection of arrhythmias, which will result in a better oriented treatment. PMID:24658228

  1. Effect of Learning Activity on Students' Motivation, Physical Activity Levels and Effort/Persistence

    ERIC Educational Resources Information Center

    Gao, Zan; Lee, Amelia M.; Xiang, Ping; Kosma, Maria

    2011-01-01

    The type of learning activity offered in physical education may influence students' motivational beliefs, physical activity participation and effort/persistence in class. However, most empirical studies have focused on the individual level rather than on the learner-content interactions. Accordingly, the potential effects of learning activities on…

  2. Pedagogical Distance: Explaining Misalignment in Student-Driven Online Learning Activities Using Activity Theory

    ERIC Educational Resources Information Center

    Westberry, Nicola; Franken, Margaret

    2015-01-01

    This paper provides an Activity Theory analysis of two online student-driven interactive learning activities to interrogate assumptions that such groups can effectively learn in the absence of the teacher. Such an analysis conceptualises learning tasks as constructed objects that drive pedagogical activity. The analysis shows a disconnect between…

  3. Attitudinal Effects of a Student-Centered Active Learning Environment

    NASA Astrophysics Data System (ADS)

    Oliver-Hoyo, Maria T.; Allen, Deedee

    2005-06-01

    The importance of attitudes toward science has risen from widely accepted assumptions that achievement and attitude are positively interdependent and that affective variables are as important as cognitive variables in molding student learning. This report examines the effect on student attitudes toward learning chemistry in an active learning environment that has incorporated elements believed to positively influence student attitudes toward science including cooperative learning, hands-on activities, real-world applications, and engaging technology. These elements were considered for synergetic effects and not as individual contributors to the overall results. Two different sections of the same general chemistry course participated. The lecture setting was used as the control. Residualized gain scores were used to compare net changes in student attitudes. Data were analyzed for possible differences in gain for different academic majors. Anxiety in chemistry was monitored for the two class settings in three areas, learning in chemistry, chemistry evaluation, and chemical handling. Qualitative student feedback was also collected and is summarized in this report on the attitudinal aspects of instruction.

  4. Risks to children from exposure to lead in air during remedial or removal activities at Superfund sites: a case study of the RSR lead smelter Superfund site.

    PubMed

    Khoury, Ghassan A; Diamond, Gary L

    2003-01-01

    Superfund sites that are contaminated with lead and undergoing remedial action generate lead-enriched dust that can be released into the air. Activities that can emit lead-enriched dust include demolition of lead smelter buildings, stacks, and baghouses; on-site traffic of heavy construction vehicles; and excavation of soil. Typically, air monitoring stations are placed around the perimeter of a site of an ongoing remediation to monitor air lead concentrations that might result from site emissions. The National Ambient Air Quality (NAAQ) standard, established in 1978 to be a quarterly average of 1.5 microg/m(3), is often used as a trigger level for corrective action to reduce emissions. This study explored modeling approaches for assessing potential risks to children from air lead emissions from the RSR Superfund site in West Dallas, TX, during demolition and removal of a smelter facility. The EPA Integrated Exposure Uptake Biokinetic (IEUBK) model and the International Commission of Radiologic Protection (ICRP) lead model were used to simulate blood lead concentrations in children, based on monitored air lead concentrations. Although air lead concentrations at monitoring stations located in the downwind community intermittently exceeded the NAAQ standard, both models indicated that exposures to children in the community areas did not pose a significant long-term or acute risk. Long-term risk was defined as greater than 5% probability of a child having a long-term blood lead concentration that exceeded 10 microg/dl, which is the CDC and the EPA blood lead concern level. Short-term or acute risk was defined as greater than 5% probability of a child having a blood lead concentration on any given day that exceeded 20 microg/dl, which is the CDC trigger level for medical evaluation (this is not intended to imply that 20 microg/dl is a threshold for health effects in children exposed acutely to airborne lead). The estimated potential long-term and short-term exposures

  5. Can Computer-Based Visual-Spatial Aids Lead to Increased Student Performance in Anatomy & Physiology?

    ERIC Educational Resources Information Center

    Kesner, Michael H.; Linzey, Alicia V.

    2005-01-01

    InterActive Physiology (IAP) is one of a new generation of anatomy and physiology learning aids with a broader range of sensory inputs than is possible from a static textbook or moderately dynamic lecture. This best-selling software has modules covering the muscular, respiratory, urinary, cardiovascular, and nervous systems plus a module on fluids…

  6. An Inquiry "Warm-Up" Activity: Preparing Students for an Active Classroom Community

    NASA Astrophysics Data System (ADS)

    Seagroves, S.

    2010-12-01

    An active learning community that engages in inquiry activities will employ strategies and structures that students from traditional classrooms may find unfamiliar or uncomfortable. These include group work, voicing questions, shifting from one part of an activity to another (and sometimes shifting groups at the same time), presenting informally to the group, and many others. In addition, the role of the instructor as facilitator rather than teacher may not be familiar to students. As inquiry activities become incorporated into the regular classroom curriculum at Maui Community College (through collaboration with the Professional Development Program as part of the Akamai Workforce Initiative), a need emerged to give students a "warm-up" early in the semester to help them practice these participation structures. This activity was designed to be used on the very first day of class, to be easy and accessible to students, and to give them practice with these features of inquiry activities that they would see again throughout the semester. In addition, the activity introduces the engineering technology concepts of requirements, trade-offs, and limitations. It is important to note that this activity is not in and of itself an inquiry activity; in fact the content and processes featured in the activity are not particularly challenging nor are they the main focus. Instead, this is a "warm-up" for inquiry, so that students gain some comfort with the unconventional features of inquiry activities. The particular activity presented is for 20-30 students in a ˜90 minute lab period, and highlights different imaging technologies of cameras; however, it is easily adaptable to other requirements, to different technology, or other needs.

  7. Students' and experts' perspectives on three learning and teaching activities.

    PubMed

    Chan, Zenobia C Y

    2014-09-01

    Nursing is a profession that closely related to human life, and nurses are required to demonstrate critical thinking and creativity in providing health care services. However, traditional teaching approaches usually limit students' autonomy and freedom of expressing their thoughts and feelings. In order to develop the corresponding competence of nursing students, I adopted three teaching innovations, namely writing poems, composing songs, and using role plays in a nursing problem-based learning class in a university in Hong Kong. According to students' reflective notes and comments from two international expert reviewers, participating in these activities is a valuable experience and students were able to develop clinical reasoning, empathy, team spirit, motivation to learn, creativity, and ability to summarise and reconstruct knowledge. It is hoped that more innovative learning activities will be implemented, to prepare professional and ethical nurses in the future. It is also hoped that this study could provide other PBL educators some insights in innovative problem-based learning activities. PMID:24679519

  8. Pulmonary Epithelial TLR4 Activation Leads to Lung Injury in Neonatal Necrotizing Enterocolitis.

    PubMed

    Jia, Hongpeng; Sodhi, Chhinder P; Yamaguchi, Yukihiro; Lu, Peng; Martin, Laura Y; Good, Misty; Zhou, Qinjie; Sung, Jungeun; Fulton, William B; Nino, Diego F; Prindle, Thomas; Ozolek, John A; Hackam, David J

    2016-08-01

    We seek to define the mechanisms leading to the development of lung disease in the setting of neonatal necrotizing enterocolitis (NEC), a life-threatening gastrointestinal disease of premature infants characterized by the sudden onset of intestinal necrosis. NEC development in mice requires activation of the LPS receptor TLR4 on the intestinal epithelium, through its effects on modulating epithelial injury and repair. Although NEC-associated lung injury is more severe than the lung injury that occurs in premature infants without NEC, the mechanisms leading to its development remain unknown. In this study, we now show that TLR4 expression in the lung gradually increases during postnatal development, and that mice and humans with NEC-associated lung inflammation express higher levels of pulmonary TLR4 than do age-matched controls. NEC in wild-type newborn mice resulted in significant pulmonary injury that was prevented by deletion of TLR4 from the pulmonary epithelium, indicating a role for pulmonary TLR4 in lung injury development. Mechanistically, intestinal epithelial TLR4 activation induced high-mobility group box 1 release from the intestine, which activated pulmonary epithelial TLR4, leading to the induction of the neutrophil recruiting CXCL5 and the influx of proinflammatory neutrophils to the lung. Strikingly, the aerosolized administration of a novel carbohydrate TLR4 inhibitor prevented CXCL5 upregulation and blocked NEC-induced lung injury in mice. These findings illustrate the critical role of pulmonary TLR4 in the development of NEC-associated lung injury, and they suggest that inhibition of this innate immune receptor in the neonatal lung may prevent this devastating complication of NEC. PMID:27307558

  9. Understanding, Evaluating and Assessing What Students Learn from Leadership Activities: Student Research in Woodlea Primary

    ERIC Educational Resources Information Center

    Thomson, Pat

    2012-01-01

    Student involvement in leadership activities is now common in English schools. It is generally assumed to have beneficial learning outcomes and there is some research which suggests that this is the case. However, there is still work to do to detail these learning outcomes--and to assess them. I present one case in which primary school students…

  10. Assisting in the Medical Laboratory. Instructor's Guide, Students' Manual, and Student Learning Activities.

    ERIC Educational Resources Information Center

    Fair, Helena J.

    The instructor's guide, the first of three documents in this package, is for a course to help students who are investigating the activities within a hospital, clinic, or physician's office. The material is designed to relate training experience to information studied in the classroom. The course is intended for individualized study and is…

  11. Challenging Science and Literacy Activities for K-9 Students - The Cricket Chronicles: Student Edition

    ERIC Educational Resources Information Center

    Matthews, Catherine E.

    2006-01-01

    This is an extensive integrated unit of study focused on that common and familiar insect-the cricket. In this edition, students are provided with more than 30 activities on crickets, which will help them learn science content and skills including: (1) Taxonomy; (2) Anatomy; (3) Ecology; (4) Mark and recapture techniques for estimating population…

  12. Assisting in Radiology/Imaging. Instructor's Guide, Student's Manual, and Student Learning Activities.

    ERIC Educational Resources Information Center

    Fair, Helena J.

    The instructor's guide, the first of three documents in this package, is designed for a course to help students who are investigating the activities within a radiology department or considering any of the imaging technologies as a career. The material is designed to relate training experience to information studied in the classroom. This…

  13. A Greenhouse Study on Lead Uptake and Antioxidant Enzyme Activities in Vetiver Grass (Vetiveria zizanioides) as a Function of Lead Concentration and Soil Physico-Chemical Properties

    NASA Astrophysics Data System (ADS)

    Andra, S. P.; Datta, R.; Sarkar, D.; Saminathan, S. K.

    2006-05-01

    Lead (Pb) is a toxic non-essential metal that can cause permanent learning disabilities, retardation, mental and behavioral problems in children. Lead accumulation in soils result from weathering, chipping, scraping, sanding and sand blasting of housing structures constructed prior to 1978, bearing lead-based paint. The primary objective of this study is to develop a cost-effective, chelate-assisted phytoremediation for cleaning up lead contaminated soils. Soils are a unique environment of diverse physical and chemical characteristics that influence the extent of phytoavailable (labile) Pb forms. The success of phytoremediation strategy depends on the physiological/ biochemical tolerance of the plants to lipid peroxidation induced by Pb at sub-lethal levels. Oxidative challenge is alleviated by antioxidant compounds, but more importantly by the induction of antioxidant enzymes, which are crucial for scavenging reactive oxygen species (ROS) and terminating lipid peroxidation chain reaction. A column study was conducted in a temperature and humidity-controlled greenhouse setting to assess the extent of Pb phytoextraction and antioxidant response in a lead accumulator, vetiver grass (Vetiveria zizanioides). Treatments consisted of a randomized block arrangement of 4 soil types (Immokalee, Pahokee Muck, Tobosa, and Millhopper) and 3 soil Pb concentrations [normal - 400 mg/kg lead (following federal soil standards for lead), moderate - 800 mg/kg lead, and excessive - 1200 mg/kg lead] in 4 replicates. At the end of 6 months, selected columns were amended with a biodegradable chelating agent, ethylenediamene disuccinate (10 mmol/ kg EDDS), to mobilize Pb and enhance Pb uptake by vetiver. Total and exchangeable (labile) Pb were correlated with phytoextracted Pb, and levels of antioxidant enzymes viz., superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in the root and shoot tissues of vetiver grass. Results indicate that Pb uptake and antioxidant

  14. 24 CFR 1000.40 - Do lead-based paint poisoning prevention requirements apply to affordable housing activities...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Do lead-based paint poisoning... AMERICAN HOUSING ACTIVITIES General § 1000.40 Do lead-based paint poisoning prevention requirements apply..., subparts A, B, H, J, K, M and R of this title, which implement the Lead-Based Paint Poisoning...

  15. 24 CFR 1000.40 - Do lead-based paint poisoning prevention requirements apply to affordable housing activities...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 4 2011-04-01 2011-04-01 false Do lead-based paint poisoning... AMERICAN HOUSING ACTIVITIES General § 1000.40 Do lead-based paint poisoning prevention requirements apply..., subparts A, B, H, J, K, M and R of this title, which implement the Lead-Based Paint Poisoning...

  16. 24 CFR 1000.40 - Do lead-based paint poisoning prevention requirements apply to affordable housing activities...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 4 2014-04-01 2014-04-01 false Do lead-based paint poisoning... AMERICAN HOUSING ACTIVITIES General § 1000.40 Do lead-based paint poisoning prevention requirements apply..., subparts A, B, H, J, K, M and R of this title, which implement the Lead-Based Paint Poisoning...

  17. 24 CFR 1000.40 - Do lead-based paint poisoning prevention requirements apply to affordable housing activities...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 4 2013-04-01 2013-04-01 false Do lead-based paint poisoning... AMERICAN HOUSING ACTIVITIES General § 1000.40 Do lead-based paint poisoning prevention requirements apply..., subparts A, B, H, J, K, M and R of this title, which implement the Lead-Based Paint Poisoning...

  18. Antihyperglycemic activities of cryptolepine analogues: an ethnobotanical lead structure isolated from Cryptolepis sanguinolenta.

    PubMed

    Bierer, D E; Dubenko, L G; Zhang, P; Lu, Q; Imbach, P A; Garofalo, A W; Phuan, P W; Fort, D M; Litvak, J; Gerber, R E; Sloan, B; Luo, J; Cooper, R; Reaven, G M

    1998-07-16

    Cryptolepine (1) is a rare example of a natural product whose synthesis was reported prior to its isolation from nature. In the previous paper we reported the discovery of cryptolepine's antihyperglycemic properties. As part of a medicinal chemistry program designed to optimize natural product lead structures originating from our ethnobotanical and ethnomedical field research, a series of substituted and heterosubstituted cryptolepine analogues was synthesized. Antihyperglycemic activity was measured in vitro and in an NIDDM mouse model to generate the first structure-bioactivity study about the cryptolepine nucleus. PMID:9667966

  19. 78 FR 48660 - Agency Information Collection Activities; Comment Request; Student Assistance General Provisions...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-09

    ... Agency Information Collection Activities; Comment Request; Student Assistance General Provisions--Subpart K--Cash Management AGENCY: Federal Student Aid (FSA), Department of Education (ED). ACTION: Notice... notice will be considered public records. Title of Collection: Student Assistance General...

  20. 78 FR 63972 - Agency Information Collection Activities; Comment Request; Student Assistance General Provisions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-25

    ... Agency Information Collection Activities; Comment Request; Student Assistance General Provisions AGENCY: Federal Student Aid (FSA), Department of Education (ED). ACTION: Notice. SUMMARY: In accordance with the... considered public records. Title of Collection: Student Assistance General Provisions. OMB Control...

  1. Intercollegiate Athletics or Student Activities and Recreation Programs: One College's Decision.

    ERIC Educational Resources Information Center

    Pelletier, Dennis M.; Peterson, Katherine E.

    1986-01-01

    Summarizes the process that the University of Baltimore underwent in making a succesful transition from intercollegiate athletics for a few students to a program of lifetime sports, recreation, and expanded student activities for all students. (Author)

  2. Lead Poisoning

    MedlinePlus

    ... our environment. Much of it comes from human activities such as mining and manufacturing. Lead used to be in paint; older houses may still have lead paint. You could be exposed to lead by Eating food or drinking water that contains lead. Water pipes in older homes ...

  3. Involvement of microglia activation in the lead induced long-term potentiation impairment.

    PubMed

    Liu, Ming-Chao; Liu, Xin-Qin; Wang, Wen; Shen, Xue-Feng; Che, Hong-Lei; Guo, Yan-Yan; Zhao, Ming-Gao; Chen, Jing-Yuan; Luo, Wen-Jing

    2012-01-01

    Exposure of Lead (Pb), a known neurotoxicant, can impair spatial learning and memory probably via impairing the hippocampal long-term potentiation (LTP) as well as hippocampal neuronal injury. Activation of hippocampal microglia also impairs spatial learning and memory. Thus, we raised the hypothesis that activation of microglia is involved in the Pb exposure induced hippocampal LTP impairment and neuronal injury. To test this hypothesis and clarify its underlying mechanisms, we investigated the Pb-exposure on the microglia activation, cytokine release, hippocampal LTP level as well as neuronal injury in in vivo or in vitro model. The changes of these parameters were also observed after pretreatment with minocycline, a microglia activation inhibitor. Long-term low dose Pb exposure (100 ppm for 8 weeks) caused significant reduction of LTP in acute slice preparations, meanwhile, such treatment also significantly increased hippocampal microglia activation as well as neuronal injury. In vitro Pb-exposure also induced significantly increase of microglia activation, up-regulate the release of cytokines including tumor necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β) and inducible nitric oxide synthase (iNOS) in microglia culture alone as well as neuronal injury in the co-culture with hippocampal neurons. Inhibiting the microglia activation with minocycline significantly reversed the above-mentioned Pb-exposure induced changes. Our results showed that Pb can cause microglia activation, which can up-regulate the level of IL-1β, TNF-α and iNOS, these proinflammatory factors may cause hippocampal neuronal injury as well as LTP deficits. PMID:22952811

  4. Chitosan leads to downregulation of YKL-40 and inflammasome activation in human macrophages.

    PubMed

    Gudmundsdottir, Steinunn; Lieder, Ramona; Sigurjonsson, Olafur E; Petersen, Petur H

    2015-08-01

    Chitosan, the deacetylated derivative of chitin, is used as biomaterial in diverse settings. It is also found on pathogens and can be proinflammatory. Shorter derivatives of chitosan can be generated chemically or enzymatically, chitosan oligosaccharides (ChOS). There is variation in the chemical composition of ChOS, including size distribution, but in general, they have been described as inert or anti-inflammatory. Active human chitinases can cleave chitin and chitosan, while inactive chitinases bind both but do not cleave. Both active and inactive chitinases have important roles in the immune response. The inactive chitinase YKL-40 is expressed highly during inflammation and has been proposed as a marker of poor prognosis. YKL-40 acts as a negative regulator of the inflammasome and as a positive regulator of angiogenesis. Levels of YKL-40 can therefore regulate levels of inflammation, the extent of angiogenesis, and the process of inflammation resolution. This study shows that chitosan leads to reduced secretion of YKL-40 by primary human macrophages and that this is concomitant with inflammasome activation. This was most pronounced with a highly deacetylated ChOS. No effect on the secretion of the active chitinase Chit-1 was detected. Smaller and more acetylated ChOS did not affect YKL-40 levels nor inflammasome activation. We conclude that this effect on the levels of YKL-40 is a part of the proinflammatory mechanisms of chitosan and its derivatives. PMID:25684555

  5. Astronomical Activities for students-Motivating students interest in Physical Science through Astronomy

    NASA Astrophysics Data System (ADS)

    Matthaiou, Alexis

    2010-05-01

    Astronomical Activities for students Motivating students interest in Physical Science through Astronomy Alexis Matthaiou Philekpaideftiki Etaireia, Arsakeio Lyceum Patron, Patras, Greece,(alexiosmat@yahoo.gr) School education aims not only to providing the necessary knowledge to the students but also to inspire and motivate them to realize their special abilities and inclinations and use their potential for making a joyful future for their lives. In this direction we present some activities held in the Arsakeio School of Patras during the years 2005-2008 in the field of Astronomy and Astrophysics, in order to share our experience with the teachers' community. Students from all grades of primary and secondary education participated with enthusiasm. In particular, they observed the Partial Solar Eclipse of October 3rd, 2005,and the Total Solar Eclipse of March 29th, 2006. They took part in observing and registering Solar Spots, using Astronomical equipments like different types of telescopes with filters and solar scopes. Students studied further the nature of Solar Phenomena and their effects on life, participating in the Environmental Program "Sun and Life"(2006-2007). Moreover, students took part in the International Program for measuring the Light Pollution "Globe at Night" (2006-2007) with observing and registering the luminosity of the Orion constellation in the night sky above their residence. Finally, the students participated in the European program "Hands on Universe" (HOU) (2005-2008) working on a project, which was the Greek contribution to HOU, developed from "Philekpaideftiki Etaireia". In particular, they studied the stars' spectrum and acquired information about the stars' life and age of stellar systems, using interactive multimedia technology.

  6. Biosorption of toxic lead (II) ions using tomato waste (Solanum lycopersicum) activated by NaOH

    NASA Astrophysics Data System (ADS)

    Permatasari, Diah; Heraldy, Eddy; Lestari, Witri Wahyu

    2016-02-01

    This research present to uptake lead (II) ion from aqueous solutions by activated tomato waste. Biosorbent were characterized by applying Fourier Transform Infrared Spectroscopy (FTIR) and Surface Area Analyzer (SAA). The biosorption investigated with parameters including the concentration of NaOH, effects of solution pH, biosorbent dosage, contact time,and initial metal concentration. Experimental data were analyzed in terms of two kinetic model such us the pseudo-first order and pseudo-second order. Langmuir and Freundlich isotherm models were applied todescribe the biosorption process. According to the experiment, the optimum concentration of NaOH was achieved at 0.1 M. The maximum % lead (II) removal was achieved at pH 4 with 94.5%. Optimum biosorbentdosage were found as 0.1 g/25 mL solution while optimum contact time were found at 75 minutes. The results showed that the biosorption processes of Lead (II) followed pseudo-second order kinetics. Langmuir adsorption isotherm was found fit the adsorption data with amaximum capacity of 24.079 mg/g with anadsorption energy of 28.046 kJ/mol.

  7. Convergent mutations and kinase fusions lead to oncogenic STAT3 activation in anaplastic large cell lymphoma.

    PubMed

    Crescenzo, Ramona; Abate, Francesco; Lasorsa, Elena; Tabbo', Fabrizio; Gaudiano, Marcello; Chiesa, Nicoletta; Di Giacomo, Filomena; Spaccarotella, Elisa; Barbarossa, Luigi; Ercole, Elisabetta; Todaro, Maria; Boi, Michela; Acquaviva, Andrea; Ficarra, Elisa; Novero, Domenico; Rinaldi, Andrea; Tousseyn, Thomas; Rosenwald, Andreas; Kenner, Lukas; Cerroni, Lorenzo; Tzankov, Alexander; Ponzoni, Maurilio; Paulli, Marco; Weisenburger, Dennis; Chan, Wing C; Iqbal, Javeed; Piris, Miguel A; Zamo', Alberto; Ciardullo, Carmela; Rossi, Davide; Gaidano, Gianluca; Pileri, Stefano; Tiacci, Enrico; Falini, Brunangelo; Shultz, Leonard D; Mevellec, Laurence; Vialard, Jorge E; Piva, Roberto; Bertoni, Francesco; Rabadan, Raul; Inghirami, Giorgio

    2015-04-13

    A systematic characterization of the genetic alterations driving ALCLs has not been performed. By integrating massive sequencing strategies, we provide a comprehensive characterization of driver genetic alterations (somatic point mutations, copy number alterations, and gene fusions) in ALK(-) ALCLs. We identified activating mutations of JAK1 and/or STAT3 genes in ∼20% of 88 [corrected] ALK(-) ALCLs and demonstrated that 38% of systemic ALK(-) ALCLs displayed double lesions. Recurrent chimeras combining a transcription factor (NFkB2 or NCOR2) with a tyrosine kinase (ROS1 or TYK2) were also discovered in WT JAK1/STAT3 ALK(-) ALCL. All these aberrations lead to the constitutive activation of the JAK/STAT3 pathway, which was proved oncogenic. Consistently, JAK/STAT3 pathway inhibition impaired cell growth in vitro and in vivo. PMID:25873174

  8. Reverse evolution leads to genotypic incompatibility despite functional and active site convergence.

    PubMed

    Kaltenbach, Miriam; Jackson, Colin J; Campbell, Eleanor C; Hollfelder, Florian; Tokuriki, Nobuhiko

    2015-01-01

    Understanding the extent to which enzyme evolution is reversible can shed light on the fundamental relationship between protein sequence, structure, and function. Here, we perform an experimental test of evolutionary reversibility using directed evolution from a phosphotriesterase to an arylesterase, and back, and examine the underlying molecular basis. We find that wild-type phosphotriesterase function could be restored (>10(4)-fold activity increase), but via an alternative set of mutations. The enzyme active site converged towards its original state, indicating evolutionary constraints imposed by catalytic requirements. We reveal that extensive epistasis prevents reversions and necessitates fixation of new mutations, leading to a functionally identical sequence. Many amino acid exchanges between the new and original enzyme are not tolerated, implying sequence incompatibility. Therefore, the evolution was phenotypically reversible but genotypically irreversible. Our study illustrates that the enzyme's adaptive landscape is highly rugged, and different functional sequences may constitute separate fitness peaks. PMID:26274563

  9. An investigation of the impact of selected prereading activities on student content learning through laboratory activities

    NASA Astrophysics Data System (ADS)

    Kass, Jesse (Shaya)

    This study investigated whether two prereading activities impacted student learning from hands-on science activities. The study was based on constructivist learning theory. Based on the work of Piaget, it was hypothesized that students who activated prior knowledge would learn more from the activities. Based on the work of Vygotsky it was hypothesized that students who talk more and write more would learn more from the activity. The K-W-L chart and anticipation guide strategies were used with eighth grade students at Graves Middle School in Whittier, California before learning about levers and convection currents. D. M. Ogle (1986) created the three-column K-W-L chart to have students activate prior knowledge. In the first column, the students write what they already know about a subject, in the second column, the students write what they want to know about the subject, and the students complete the third column after learning about a subject by writing answers to the questions that they asked in the second column. Duffelmeyer (1994) created the anticipation guide based on Herber's (1978) reasoning guide. In the anticipation guide, the teacher creates three or four sentences that convey the major ideas of the topic and the students either agree or disagree with the statements. After learning about the topic, students revisit their answers and decide if they were correct or incorrect and they must defend their choices. This research used the Solomon (1947) four-square design and compared both the experimental groups to a control group that simply discussed the concepts before completing the activity. The research showed no significant difference between the control group and either of the treatment groups. The reasons for the lack of significant differences are considered. It was hypothesized that since the students were unfamiliar with the prereading activities and did not have much experience with using either writing-to-learn or talking-to-learn strategies, the

  10. An increase in the Na+/K+-ATPase activity of erythrocyte membranes in workers employed in a lead refining factory.

    PubMed Central

    Karai, I; Fukumoto, K; Horiguchi, S

    1982-01-01

    To clarify the relationship between erythrocyte Na+/K+-ATPase activity and haematological findings, several clinical laboratory examinations were performed on 31 male workers employed in a scrap lead refining factory and, as controls, 50 male workers employed in railway construction. The results were: (1) Values for erythrocyte Na+/K+-ATPase activity, blood and urine lead, urine delta-aminolaevulinic acid, and urine coproporphyrin of lead workers were significantly higher than those of the controls (p less than 0.01). (2) A strongly positive relationship between blood lead and erythrocyte Na/K-ATPase activity was observed in lead workers (r = 0.473, p less than 0.01). (3) A strongly negative relationship between Na+/K+-ATPase activity and intracellular sodium was observed in both groups (lead workers; r = -0.601, p less than 0.01: controls; r = 0.595, p less than 0.01). PMID:6284196

  11. Aeromechanical stability augmentation using semi-active friction-based lead-lag damper

    NASA Astrophysics Data System (ADS)

    Agarwal, Sandeep

    2005-11-01

    Lead-lag dampers are present in most rotors to provide the required level of damping in all flight conditions. These dampers are a critical component of the rotor system, but they also represent a major source of maintenance cost. In present rotor systems, both hydraulic and elastomeric lead-lag dampers have been used. Hydraulic dampers are complex mechanical components that require hydraulic fluids and have high associated maintenance costs. Elastomeric dampers are conceptually simpler and provide a "dry" rotor, but are rather costly. Furthermore, their damping characteristics can degrade with time without showing external signs of failure. Hence, the dampers must be replaced on a regular basis. A semi-active friction based lead-lag damper is proposed as a replacement for hydraulic and elastomeric dampers. Damping is provided by optimized energy dissipation due to frictional forces in semi-active joints. An actuator in the joint modulates the normal force that controls energy dissipation at the frictional interfaces, resulting in large hysteretic loops. Various selective damping strategies are developed and tested for a simple system containing two different frequency modes in its response, one of which needs to be damped out. The system reflects the situation encountered in rotor response where 1P excitation is present along with the potentially unstable regressive lag motion. Simulation of the system response is obtained to compare their effectiveness. Next, a control law governing the actuation in the lag damper is designed to generate the desired level of damping for performing adaptive selective damping of individual blade lag motion. Further, conceptual design of a piezoelectric friction based lag damper for a full-scale rotor is presented and various factors affecting size, design and maintenance cost, damping capacity, and power requirements of the damper are discussed. The selective semi-active damping strategy is then studied in the context of classical

  12. Potent Plasmodium falciparum gametocytocidal activity of diaminonaphthoquinones, lead antimalarial chemotypes identified in an antimalarial compound screen.

    PubMed

    Tanaka, Takeshi Q; Guiguemde, W Armand; Barnett, David S; Maron, Maxim I; Min, Jaeki; Connelly, Michele C; Suryadevara, Praveen Kumar; Guy, R Kiplin; Williamson, Kim C

    2015-03-01

    Forty percent of the world's population is threatened by malaria, which is caused by Plasmodium parasites and results in an estimated 200 million clinical cases and 650,000 deaths each year. Drug resistance has been reported for all commonly used antimalarials and has prompted screens to identify new drug candidates. However, many of these new candidates have not been evaluated against the parasite stage responsible for transmission, gametocytes. If Plasmodium falciparum gametocytes are not eliminated, patients continue to spread malaria for weeks after asexual parasite clearance. Asymptomatic individuals can also harbor gametocyte burdens sufficient for transmission, and a safe, effective gametocytocidal agent could also be used in community-wide malaria control programs. Here, we identify 15 small molecules with nanomolar activity against late-stage gametocytes. Fourteen are diaminonaphthoquinones (DANQs), and one is a 2-imino-benzo[d]imidazole (IBI). One of the DANQs identified, SJ000030570, is a lead antimalarial candidate. In contrast, 94% of the 650 compounds tested are inactive against late-stage gametocytes. Consistent with the ineffectiveness of most approved antimalarials against gametocytes, of the 19 novel compounds with activity against known anti-asexual-stage targets, only 3 had any strong effect on gametocyte viability. These data demonstrate the distinct biology of the transmission stages and emphasize the importance of screening for gametocytocidal activity. The potent gametocytocidal activity of DANQ and IBI coupled with their efficacy against asexual parasites provides leads for the development of antimalarials with the potential to prevent both the symptoms and the spread of malaria. PMID:25512421

  13. Potent Plasmodium falciparum Gametocytocidal Activity of Diaminonaphthoquinones, Lead Antimalarial Chemotypes Identified in an Antimalarial Compound Screen

    PubMed Central

    Tanaka, Takeshi Q; Guiguemde, W. Armand; Barnett, David S.; Maron, Maxim I.; Min, Jaeki; Connelly, Michele C.; Suryadevara, Praveen Kumar; Guy, R. Kiplin

    2014-01-01

    Forty percent of the world's population is threatened by malaria, which is caused by Plasmodium parasites and results in an estimated 200 million clinical cases and 650,000 deaths each year. Drug resistance has been reported for all commonly used antimalarials and has prompted screens to identify new drug candidates. However, many of these new candidates have not been evaluated against the parasite stage responsible for transmission, gametocytes. If Plasmodium falciparum gametocytes are not eliminated, patients continue to spread malaria for weeks after asexual parasite clearance. Asymptomatic individuals can also harbor gametocyte burdens sufficient for transmission, and a safe, effective gametocytocidal agent could also be used in community-wide malaria control programs. Here, we identify 15 small molecules with nanomolar activity against late-stage gametocytes. Fourteen are diaminonaphthoquinones (DANQs), and one is a 2-imino-benzo[d]imidazole (IBI). One of the DANQs identified, SJ000030570, is a lead antimalarial candidate. In contrast, 94% of the 650 compounds tested are inactive against late-stage gametocytes. Consistent with the ineffectiveness of most approved antimalarials against gametocytes, of the 19 novel compounds with activity against known anti-asexual-stage targets, only 3 had any strong effect on gametocyte viability. These data demonstrate the distinct biology of the transmission stages and emphasize the importance of screening for gametocytocidal activity. The potent gametocytocidal activity of DANQ and IBI coupled with their efficacy against asexual parasites provides leads for the development of antimalarials with the potential to prevent both the symptoms and the spread of malaria. PMID:25512421

  14. 40 CFR 745.227 - Work practice standards for conducting lead-based paint activities: target housing and child...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... lead-based paint activities: target housing and child-occupied facilities. 745.227 Section 745.227... practice standards for conducting lead-based paint activities: target housing and child-occupied facilities... section are found in the following: The U.S. Department of Housing and Urban Development (HUD)...

  15. 40 CFR 745.227 - Work practice standards for conducting lead-based paint activities: target housing and child...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... lead-based paint activities: target housing and child-occupied facilities. 745.227 Section 745.227... practice standards for conducting lead-based paint activities: target housing and child-occupied facilities... section are found in the following: The U.S. Department of Housing and Urban Development (HUD)...

  16. 40 CFR 745.227 - Work practice standards for conducting lead-based paint activities: target housing and child...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... lead-based paint activities: target housing and child-occupied facilities. 745.227 Section 745.227... practice standards for conducting lead-based paint activities: target housing and child-occupied facilities... section are found in the following: The U.S. Department of Housing and Urban Development (HUD)...

  17. 40 CFR 745.227 - Work practice standards for conducting lead-based paint activities: target housing and child...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... lead-based paint activities: target housing and child-occupied facilities. 745.227 Section 745.227... practice standards for conducting lead-based paint activities: target housing and child-occupied facilities... section are found in the following: The U.S. Department of Housing and Urban Development (HUD)...

  18. Extracurricular Activities and Their Effect on the Student's Grade Point Average: Statistical Study

    ERIC Educational Resources Information Center

    Bakoban, R. A.; Aljarallah, S. A.

    2015-01-01

    Extracurricular activities (ECA) are part of students' everyday life; they play important roles in students' lives. Few studies have addressed the question of how student engagements to ECA affect student's grade point average (GPA). This research was conducted to know whether the students' grade point average in King Abdulaziz University,…

  19. Inhibition of Rb Phosphorylation Leads to mTORC2-Mediated Activation of Akt.

    PubMed

    Zhang, Jinfang; Xu, Kai; Liu, Pengda; Geng, Yan; Wang, Bin; Gan, Wenjian; Guo, Jianping; Wu, Fei; Chin, Y Rebecca; Berrios, Christian; Lien, Evan C; Toker, Alex; DeCaprio, James A; Sicinski, Piotr; Wei, Wenyi

    2016-06-16

    The retinoblastoma (Rb) protein exerts its tumor suppressor function primarily by inhibiting the E2F family of transcription factors that govern cell-cycle progression. However, it remains largely elusive whether the hyper-phosphorylated, non-E2F1-interacting form of Rb has any physiological role. Here we report that hyper-phosphorylated Rb directly binds to and suppresses the function of mTORC2 but not mTORC1. Mechanistically, Rb, but not p107 or p130, interacts with Sin1 and blocks the access of Akt to mTORC2, leading to attenuated Akt activation and increased sensitivity to chemotherapeutic drugs. As such, inhibition of Rb phosphorylation by depleting cyclin D or using CDK4/6 inhibitors releases Rb-mediated mTORC2 suppression. This, in turn, leads to elevated Akt activation to confer resistance to chemotherapeutic drugs in Rb-proficient cells, which can be attenuated with Akt inhibitors. Therefore, our work provides a molecular basis for the synergistic usage of CDK4/6 and Akt inhibitors in treating Rb-proficient cancer. PMID:27237051

  20. Activating Mutations in PIK3CA Lead to Widespread Modulation of the Tyrosine Phosphoproteome

    PubMed Central

    Blair, Brian G.; Pinto, Sneha M.; Nirujogi, Raja S.; Jelinek, Christine A.; Malhotra, Radhika; Kim, Min-Sik; Park, Ben Ho; Pandey, Akhilesh

    2015-01-01

    The human oncogene PIK3CA is frequently mutated in human cancers. Two hotspot mutations in PIK3CA, E545K and H1047R, have been shown to regulate widespread signaling events downstream of AKT, leading to increased cell proliferation, growth, survival, and motility. We used quantitative mass spectrometry to profile the global phosphotyrosine proteome of isogenic knock-in cell lines containing these activating mutations, where we identified 824 unique phosphopeptides. Although it is well understood that these mutations result in hyperactivation of the serine/threonine kinase AKT, we found a surprisingly widespread modulation of tyrosine phosphorylation levels of proteins in the mutant cells. In the tyrosine kinome alone, 29 tyrosine kinases were altered in their phosphorylation status. Many of the regulated phosphosites that we identified were located in the kinase domain or the canonical activation sites, indicating that these kinases and their downstream signaling pathways were activated. Our study demonstrates that there is frequent and unexpected cross-talk that occurs between tyrosine signaling pathways and serine/threonine signaling pathways activated by the canonical PI3K-AKT axis. PMID:26267517

  1. Examination of lead concentrations in new decorative enamel paints in four countries with different histories of activity in lead paint regulation.

    PubMed

    Clark, C Scott; Kumar, Abhay; Mohapatra, Piyush; Rajankar, Prashant; Nycz, Zuleica; Hambartsumyan, Amalia; Astanina, Lydia; Roda, Sandy; Lind, Caroline; Menrath, William; Peng, Hongying

    2014-07-01

    Paints with high lead concentrations (ppm) continue to be sold around the world in many developing countries and those with economies in transition representing a major preventable environmental health hazard that is being increased as the economies expand and paint consumption is increasing. Prior lead paint testing had been performed in Brazil and India and these countries were selected to examine the impact of a new regulatory limit in Brazil and the impact of efforts of non-governmental organizations and others to stop the use of lead compounds in manufacturing paints. Armenia and Kazakhstan, in Central Asia, were selected because no information on lead concentration in those regions was available, no regulatory activities were evident and non-governmental organizations in the IPEN network were available to participate. Another objective of this research was to evaluate the lead loading (µg/cm(2)) limit determined by X-Ray Fluorescence (XRF) for areas on toys that are too small to obtain a sample of sufficient size for laboratory analysis. The lead concentrations in more than three-fourths of the paints from Armenia and Kazakhstan exceeded 90 ppm, the limit in the United States, and 600 ppm, the limit in Brazil. The percentages were about one-half as high in Brazil and India. The average concentration in paints purchased in Armenia, 25,000 ppm, is among the highest that has been previously reported, that in Kazakhstan, 15,700 ppm, and India, 16,600, about median. The average concentration in Brazil, 5600 ppm, is among the lowest observed. Paints in Brazil that contained an average of 36,000 ppm before the regulatory limit became effective were below detection (< 9 ppm) in samples collected in the current study. The lack of any apparent public monitoring of paint lead content as part of regulatory enforcement makes it difficult to determine whether the regulation was a major factor contributing to the decline in lead use in these paints. Using data from the

  2. Incorporating Active Learning and Student Inquiry into an Introductory Merchandising Class

    ERIC Educational Resources Information Center

    Lee, Hyun-Hwa; Hines, Jean D.

    2012-01-01

    Many educators believe that student learning is enhanced when they are actively involved in classroom activities that require student inquiry. The purpose of this paper is to report on three student inquiry projects that were incorporated into a merchandising class with the focus on making students responsible for their learning, rather than the…

  3. Periodic Properties and Inquiry: Student Mental Models Observed during a Periodic Table Puzzle Activity

    ERIC Educational Resources Information Center

    Larson, Kathleen G.; Long, George R.; Briggs, Michael W.

    2012-01-01

    The mental models of both novice and advanced chemistry students were observed while the students performed a periodic table activity. The mental model framework seems to be an effective way of analyzing student behavior during learning activities. The analysis suggests that students do not recognize periodic trends through the examination of…

  4. Connecting with Teachers and Students through K-12 Outreach Activities

    NASA Astrophysics Data System (ADS)

    Chapman, Susan; Lindbo, David; Robinson, Clay

    2014-05-01

    The Soil Science Society of America has invested heavily in a significant outreach effort to reach teachers and students in the primary/secondary grades (K-12 grades in US/Canada) to raise awareness of soil as a critical resource. The SSSA K-12 committee has been charged with increasing interest and awareness of soil science as a scientific pursuit and career choice, and providing resources that integrate more information on soil science into biology, chemistry, physics, and earth science areas taught at multiple grade levels. Activities center around five main areas: assessment and standards, learning modules/lesson plans, website development, and books and materials, and partnership activities. Members (professionals and students) of SSSA are involved through committee participation, local events, materials review, and project development.

  5. Effects of Curricular Activity on Students' Situational Motivation and Physical Activity Levels

    ERIC Educational Resources Information Center

    Gao, Zan; Hannon, James C.; Newton, Maria; Huang, Chaoqun

    2011-01-01

    The purpose of this study was to examine (a) the effects of three curricular activities on students' situational motivation (intrinsic motivation [IM], identified regulation [IR], external regulation, and amotivation [AM]) and physical activity (PA) levels, and (b) the predictive strength of situational motivation to PA levels. Four hundred twelve…

  6. Assessing Overweight, Obesity, Diet, and Physical Activity in College Students

    ERIC Educational Resources Information Center

    Huang, Terry T.-K.; Harris, Kari Jo; Lee, Rebecca E.; Nazir, Niaman; Born, Wendi; Kaur, Harsohena

    2003-01-01

    The authors surveyed 738 college students aged 18 to 27 years to assess over weight, obesity, dietary habits, and physical activity. They used BMI (body mass index) [greater than or equal to] 25 kg/m[squared] or BMI [greater than or equal to] 85th percentile and BMI [greater than or equal to] 30 kg/m[squared] or BMI [greater than or equal to] 95th…

  7. The Ideal Science Student: Exploring the Relationship of Students' Perceptions to Their Problem Solving Activity in a Robotics Context

    ERIC Educational Resources Information Center

    Sullivan, Florence; Lin, Xiadong

    2012-01-01

    The purpose of this study is to examine the relationship of middle school students' perceptions of the ideal science student to their problem solving activity and conceptual understanding in the applied science area of robotics. Twenty-six 11 and 12 year-olds (22 boys) attending a summer camp for academically advanced students participated in the…

  8. University Student Agency, Representation, and Activism: A Case Study of Students Studying English at Universite Cheikh Anta Diop (Dakar, Senegal)

    ERIC Educational Resources Information Center

    Stafford, Casey

    2012-01-01

    This study explores and interrogates dominant representations of African university students by examining how students conceptualize and act upon their own agency. Using a qualitative case-study approach, the author examines how students actively confront the ideological and material conditions presented by schooling. [The dissertation citations…

  9. U.S. College Student Activism during an Era of Neoliberalism: A Qualitative Study of Students Against Sweatshops

    ERIC Educational Resources Information Center

    Dominguez, Rachel Fix

    2009-01-01

    This article sets out to examine the experiences of college student activists involved in Students Against Sweatshops on the Beautiful River University campus. Based on observation and interview fieldwork, the paper explores how students negotiate and understand their activism against the backdrop of neoliberalism. The paper concludes that being a…

  10. The Effectiveness of Student Extracurricular Activities in Evaluating Violent Behavior among Students in the Preparatory Year at Hail University

    ERIC Educational Resources Information Center

    Aleid, Alkhamsah Saleh

    2016-01-01

    This study aimed to examine the effectiveness of student extracurricular activities in evaluating violent behavior among students in the preparatory year at Hail University. The researcher used the descriptive analytical method, and used two tools for the purpose of the study, the study sample consisted of 104 (violent) female students from the…

  11. Partners in Science: A Model Cooperative Program Introducing High School Teachers and Students to Leading-Edge Pharmaceutical Science

    NASA Astrophysics Data System (ADS)

    Woska, Joseph R., Jr.; Collins, Danielle M.; Canney, Brian J.; Arcario, Erin L.; Reilly, Patricia L.

    2005-12-01

    Partners in Science is a cooperative program between Boehringer Ingelheim Pharmaceuticals, Inc. and area high schools in the community surrounding our Connecticut campus. It is a two-phase program that introduces high school students and teachers to the world of drug discovery and leading-edge pharmaceutical research. Phase 1 involves a series of lectures, tours, and demonstrations given by scientists within our research and development division (R&D). Phase 2 involves the selection of a small group of participants to intern for the summer in a research laboratory, working side by side with a scientist within R&D. In this manuscript, the specific aims, goals, and development of the Partners in Science program are described, as well as the syllabus/agenda, the logistics surrounding the operation of the program, and our shared personal experiences with students and teachers who have participated. Some of the pitfalls/problems associated with the program will be presented, and finally, the future direction of the program including areas of improvement and expansion are described.

  12. Active Learning and Student-centered Pedagogy Improve Student Attitudes and Performance in Introductory Biology

    PubMed Central

    Patel, Maya; Johnson, Erika; Weiss, Martha

    2009-01-01

    We describe the development and implementation of an instructional design that focused on bringing multiple forms of active learning and student-centered pedagogies to a one-semester, undergraduate introductory biology course for both majors and nonmajors. Our course redesign consisted of three major elements: 1) reordering the presentation of the course content in an attempt to teach specific content within the context of broad conceptual themes, 2) incorporating active and problem-based learning into every lecture, and 3) adopting strategies to create a more student-centered learning environment. Assessment of our instructional design consisted of a student survey and comparison of final exam performance across 3 years—1 year before our course redesign was implemented (2006) and during two successive years of implementation (2007 and 2008). The course restructuring led to significant improvement of self-reported student engagement and satisfaction and increased academic performance. We discuss the successes and ongoing challenges of our course restructuring and consider issues relevant to institutional change. PMID:19723815

  13. Active learning and student-centered pedagogy improve student attitudes and performance in introductory biology.

    PubMed

    Armbruster, Peter; Patel, Maya; Johnson, Erika; Weiss, Martha

    2009-01-01

    We describe the development and implementation of an instructional design that focused on bringing multiple forms of active learning and student-centered pedagogies to a one-semester, undergraduate introductory biology course for both majors and nonmajors. Our course redesign consisted of three major elements: 1) reordering the presentation of the course content in an attempt to teach specific content within the context of broad conceptual themes, 2) incorporating active and problem-based learning into every lecture, and 3) adopting strategies to create a more student-centered learning environment. Assessment of our instructional design consisted of a student survey and comparison of final exam performance across 3 years-1 year before our course redesign was implemented (2006) and during two successive years of implementation (2007 and 2008). The course restructuring led to significant improvement of self-reported student engagement and satisfaction and increased academic performance. We discuss the successes and ongoing challenges of our course restructuring and consider issues relevant to institutional change. PMID:19723815

  14. Impairing autophagy in retinal pigment epithelium leads to inflammasome activation and enhanced macrophage-mediated angiogenesis

    PubMed Central

    Liu, Jian; Copland, David A.; Theodoropoulou, Sofia; Chiu, Hsi An Amy; Barba, Miriam Durazo; Mak, Ka Wang; Mack, Matthias; Nicholson, Lindsay B.; Dick, Andrew D.

    2016-01-01

    Age-related decreases in autophagy contribute to the progression of age-related macular degeneration (AMD). We have now studied the interaction between autophagy impaired in retinal pigment epithelium (RPE) and the responses of macrophages. We find that dying RPE cells can activate the macrophage inflammasome and promote angiogenesis. In vitro, inhibiting rotenone-induced autophagy in RPE cells elicits caspase-3 mediated cell death. Co-culture of damaged RPE with macrophages leads to the secretion of IL-1β, IL-6 and nitrite oxide. Exogenous IL-6 protects the dysfunctional RPE but IL-1β causes enhanced cell death. Furthermore, IL-1β toxicity is more pronounced in dysfunctional RPE cells showing reduced IRAK3 gene expression. Co-culture of macrophages with damaged RPE also elicits elevated levels of pro-angiogenic proteins that promote ex vivo choroidal vessel sprouting. In vivo, impaired autophagy in the eye promotes photoreceptor and RPE degeneration and recruitment of inflammasome-activated macrophages. The degenerative tissue environment drives an enhanced pro-angiogenic response, demonstrated by increased size of laser-induced choroidal neovascularization (CNV) lesions. The contribution of macrophages was confirmed by depletion of CCR2+ monocytes, which attenuates CNV in the presence of RPE degeneration. Our results suggest that the interplay between perturbed RPE homeostasis and activated macrophages influences key features of AMD development. PMID:26847702

  15. The combined effects of atrazine and lead (Pb): relative microbial activities and herbicide dissipation.

    PubMed

    Chen, Qinglin; Wang, Hui; Yang, Baoshan; He, Fei

    2014-04-01

    The experiment was conducted to investigate the effects of single and combined pollution from different concentrations of atrazine (field rate, FR, 2.0 mg kg(-1) and 5 times FR, 10 mg kg(-1)) and lead (Pb) (300 mg kg(-1) and 600 mg kg(-1)) on enzyme activity, basal soil respiration (BSR), and net nitrogen (N) mineralization (NNM) in soil after exposure for 0, 7, 14, 21, and 28 days. In addition, residual atrazine was measured in the samples of combined contamination. Results showed that the notable effects of either or both contaminants on the microbial activity and biological processes. Enzyme activity data demonstrated that the order of sensitivity to contamination was urease>invertase>catalase. BSR was strongly stimulated by atrazine/Pb at the early exposure (0-7 days for single contaminant and 7-14 days for combined contaminants). The stimulation effects on BSR were higher at low concentrations of the contamination (FR and Pb300). The combined treatments of 5FR+Pb600 inhibit BSR and NNM. Overall, the parameters associated with N cycling (urease and NNM) were more sensitive than others. Both Pb concentrations (300 and 600 mg/kg) had little influence on the dissipation of high concentrations of atrazine (5FR) during the 28-day-incubation. This study has provided useful information on potential ecotoxicology effects of combined contamination of atrazine and Pb on relative microbial biological process. PMID:24580827

  16. Digital Media Use and Social Engagement: How Social Media and Smartphone Use Influence Social Activities of College Students.

    PubMed

    Kim, Yonghwan; Wang, Yuan; Oh, Jeyoung

    2016-04-01

    Social media and mobile phones have emerged as important platforms for college students' communication activities. This study examined how college students' psychological need to belong is associated with their use of social media and smartphones. In addition, it further investigated the effects of college students' digital media use on their social engagement. Findings revealed that students' need to belong was positively related with their use of social media and smartphones, which could further facilitate their social engagement. Moreover, the relationship between the need to belong and social engagement was mediated by college students' digital media use. This study offers empirical evidence of the positive effects of digital media on social behaviors and contributed to further understanding about the mechanisms by which need to belong leads to social engagement through digital media use. PMID:26991638

  17. Conformational Restriction Leading to a Selective CB2 Cannabinoid Receptor Agonist Orally Active Against Colitis

    PubMed Central

    2014-01-01

    The CB2 cannabinoid receptor has been implicated in the regulation of intestinal inflammation. Following on from the promising activity of a series of 4-oxo-1,4-dihydroquinoline-3-carboxamide, we developed constrained analogues based on a 2H-pyrazolo[4,3-c]quinolin-3(5H)-one scaffold, with improved affinity for the hCB2 receptor and had very high selectivity over the hCB1 receptor. Importantly, the lead of this series (26, hCB2: Ki = 0.39 nM, hCB1: Ki > 3000 nM) was found to protect mice against experimental colitis after oral administration. PMID:25699149

  18. Monitoring the Progression of Structure-Activity Relationship Information during Lead Optimization.

    PubMed

    Shanmugasundaram, Veerabahu; Zhang, Liying; Kayastha, Shilva; de la Vega de León, Antonio; Dimova, Dilyana; Bajorath, Jürgen

    2016-05-12

    Lead optimization (LO) in medicinal chemistry is largely driven by hypotheses and depends on the ingenuity, experience, and intuition of medicinal chemists, focusing on the key question of which compound should be made next. It is essentially impossible to predict whether an LO project might ultimately be successful, and it is also very difficult to estimate when a sufficient number of compounds has been evaluated to judge the odds of a project. Given the subjective nature of LO decisions and the inherent optimism of project teams, very few attempts have been made to systematically evaluate project progression. Herein, we introduce a computational framework to follow the evolution of structure-activity relationship (SAR) information over a time course. The approach is based on the use of SAR matrix data structures as a diagnostic tool and enables graphical analysis of SAR redundancy and project progression. This framework should help the process of making decisions in close-in analogue work. PMID:26569348

  19. Physical Activity Patterns and Psychological Correlates of Physical Activity among Singaporean Primary, Secondary, and Junior College Students

    ERIC Educational Resources Information Center

    Wang, C. K. John; Koh, K. T.; Biddle, Stuart J. H.; Liu, W. C.; Chye, Stefanie

    2011-01-01

    The purpose of this research was to examine physical activity patterns and psychological correlates of physical activity among primary, secondary, and junior college students in Singapore. A sample of 3,333 school students aged 10 to 18 years took part in the study. Results showed that the younger students had significantly higher physical…

  20. Differential Reovirus-Specific and Herpesvirus-Specific Activator Protein 1 Activation of Secretogranin II Leads to Altered Virus Secretion

    PubMed Central

    Berard, Alicia R.; Severini, Alberto

    2015-01-01

    ABSTRACT Viruses utilize host cell machinery for propagation and manage to evade cellular host defense mechanisms in the process. Much remains unknown regarding how the host responds to viral infection. We recently performed global proteomic screens of mammalian reovirus TIL- and T3D-infected and herpesvirus (herpes simplex virus 1 [HSV-1])-infected HEK293 cells. The nonenveloped RNA reoviruses caused an upregulation, whereas the enveloped DNA HSV-1 caused a downregulation, of cellular secretogranin II (SCG2). SCG2, a member of the granin family that functions in hormonal peptide sorting into secretory vesicles, has not been linked to virus infections previously. We confirmed SCG2 upregulation and found SCG2 phosphorylation by 18 h postinfection (hpi) in reovirus-infected cells. We also found a decrease in the amount of reovirus secretion from SCG2 knockdown cells. Similar analyses of cells infected with HSV-1 showed an increase in the amount of secreted virus. Analysis of the stress-activated protein kinase (SAPK)/Jun N-terminal protein kinase (JNK) pathway indicated that each virus activates different pathways leading to activator protein 1 (AP-1) activation, which is the known SCG2 transcription activator. We conclude from these experiments that the negative correlation between SCG2 quantity and virus secretion for both viruses indicates a virus-specific role for SCG2 during infection. IMPORTANCE Mammalian reoviruses affect the gastrointestinal system or cause respiratory infections in humans. Recent work has shown that all mammalian reovirus strains (most specifically T3D) may be useful oncolytic agents. The ubiquitous herpes simplex viruses cause common sores in mucosal areas of their host and have coevolved with hosts over many years. Both of these virus species are prototypical representatives of their viral families, and investigation of these viruses can lead to further knowledge of how they and the other more pathogenic members of their respective

  1. MAPK pathway activation by chronic lead-exposure increases vascular reactivity through oxidative stress/cyclooxygenase-2-dependent pathways

    SciTech Connect

    Simões, Maylla Ronacher; Aguado, Andrea; Fiorim, Jonaína; Silveira, Edna Aparecida; Azevedo, Bruna Fernandes; Toscano, Cindy Medice; Zhenyukh, Olha; Briones, Ana María; Alonso, María Jesús; Vassallo, Dalton Valentim; Salaices, Mercedes

    2015-03-01

    Chronic exposure to low lead concentration produces hypertension; however, the underlying mechanisms remain unclear. We analyzed the role of oxidative stress, cyclooxygenase-2-dependent pathways and MAPK in the vascular alterations induced by chronic lead exposure. Aortas from lead-treated Wistar rats (1st dose: 10 μg/100 g; subsequent doses: 0.125 μg/100 g, intramuscular, 30 days) and cultured aortic vascular smooth muscle cells (VSMCs) from Sprague Dawley rats stimulated with lead (20 μg/dL) were used. Lead blood levels of treated rats attained 21.7 ± 2.38 μg/dL. Lead exposure increased systolic blood pressure and aortic ring contractile response to phenylephrine, reduced acetylcholine-induced relaxation and did not affect sodium nitroprusside relaxation. Endothelium removal and L-NAME left-shifted the response to phenylephrine more in untreated than in lead-treated rats. Apocynin and indomethacin decreased more the response to phenylephrine in treated than in untreated rats. Aortic protein expression of gp91(phox), Cu/Zn-SOD, Mn-SOD and COX-2 increased after lead exposure. In cultured VSMCs lead 1) increased superoxide anion production, NADPH oxidase activity and gene and/or protein levels of NOX-1, NOX-4, Mn-SOD, EC-SOD and COX-2 and 2) activated ERK1/2 and p38 MAPK. Both antioxidants and COX-2 inhibitors normalized superoxide anion production, NADPH oxidase activity and mRNA levels of NOX-1, NOX-4 and COX-2. Blockade of the ERK1/2 and p38 signaling pathways abolished lead-induced NOX-1, NOX-4 and COX-2 expression. Results show that lead activation of the MAPK signaling pathways activates inflammatory proteins such as NADPH oxidase and COX-2, suggesting a reciprocal interplay and contribution to vascular dysfunction as an underlying mechanisms for lead-induced hypertension. - Highlights: • Lead-exposure increases oxidative stress, COX-2 expression and vascular reactivity. • Lead exposure activates MAPK signaling pathway. • ROS and COX-2 activation by

  2. Still Bringing the Vietnam War Home: Sources of Contemporary Student Activism.

    ERIC Educational Resources Information Center

    Duncan, Lauren E.; Stewart, Abigail J.

    1995-01-01

    Examined student activism concerning the Persian Gulf War. Results showed that students' reports of their parents' activities during the Vietnam War were strongly associated with students' activism. Other correlates included attitudes toward war, political consciousness, authoritarianism, and gender-role ideology. Parents' prowar attitudes had no…

  3. Chaotic....!! Active and Engaged. Effects of an active learning classroom on student retention and engagement.

    NASA Astrophysics Data System (ADS)

    Palsole, S.; Serpa, L. F.

    2014-12-01

    Scientific literacy has been defined as the foremost challenge of this decade (AAAS, 2012). The Geological Society of American in its position statement postis that due to the systemic nature of the discipline of earth science, it is the most effective way to engage students in STEM disciplines. Given that the most common place for exposure to earth sciences is at the freshman level for non majors, we decided to transform a freshman introductory geology course to an active, student centered course, using an inquiry based approach. Our focus was to ensure the students saw the earth sciences as broadly applicative field, and not an esoteric science. To achieve this goal, we developed a series of problems that required the students to apply the concepts acquired through their self guided learning into the different topics of the course. This self guided learning took the form of didactic content uploaded into the learning management system (the various elements used to deliver the content were designed video clips, short text based lectures, short formative assessments, discussion boards and other web based discovery exercises) with the class time devoted to problem solving. A comparison of student performance in the active learning classroom vs. a traditional classroom as measured on a geoscience concept inventory (the questions were chosen by a third party who was not teaching either courses) showed that the the students in the active learning classroom scored 10% higher on the average in comparison to the traditional class. In addition to this heightened performance, the students in the active classroom also showed a higher degree of content retention 8 weeks after the semester had ended. This session will share the design process, some exercises and efficacy data collected.

  4. Targeted Inactivation of GPR26 Leads to Hyperphagia and Adiposity by Activating AMPK in the Hypothalamus

    PubMed Central

    Zhang, Weiping; Shi, Yuguang

    2012-01-01

    G-protein coupled receptor 26 (GPR26) is a brain-specific orphan GPCR with high expression in the brain region that controls satiety. Depletion of GPR26 has been shown to increase fat storage in C. elegans, whereas GPR26 deficiency in the hypothalamus is associated with high genetic susceptibility to the onset of obesity in mice. However, the metabolic function of GPR26 in mammals remains elusive. Herein, we investigated a role of GPR26 in regulating energy homeostasis by generating mice with targeted deletion of the GPR26 gene. We show that GPR26 deficiency causes hyperphagia and hypometabolism, leading to early onset of diet-induced obesity. Accordingly, GPR26 deficiency also caused metabolic complications commonly associated with obesity, including glucose intolerance, hyperinsulinemia, and dyslipidemia. Moreover, consistent with hyperphagia in GPR26 null mice, GPR26 deficiency significantly increased hypothalamic activity of AMPK, a key signaling event that stimulates appetite. In further support of a regulatory role of GPR26 in satiety, GPR26 knockout mice also demonstrate hypersensitivity to treatment of rimonabant, an endocannabinoid receptor-1 antagonist commonly used to treat obesity by suppressing appetite in humans. Together, these findings identified a key role of GPR26 as a central regulator of energy homeostasis though modulation of hypothalamic AMPK activation. PMID:22815809

  5. Systemic immune activation leads to neuroinflammation and sickness behavior in mice.

    PubMed

    Biesmans, Steven; Meert, Theo F; Bouwknecht, Jan A; Acton, Paul D; Davoodi, Nima; De Haes, Patrick; Kuijlaars, Jacobine; Langlois, Xavier; Matthews, Liam J R; Ver Donck, Luc; Hellings, Niels; Nuydens, Rony

    2013-01-01

    Substantial evidence indicates an association between clinical depression and altered immune function. Systemic administration of bacterial lipopolysaccharide (LPS) is commonly used to study inflammation-associated behavioral changes in rodents. In these experiments, we tested the hypothesis that peripheral immune activation leads to neuroinflammation and depressive-like behavior in mice. We report that systemic administration of LPS induced astrocyte activation in transgenic GFAP-luc mice and increased immunoreactivity against the microglial marker ionized calcium-binding adapter molecule 1 in the dentate gyrus of wild-type mice. Furthermore, LPS treatment caused a strong but transient increase in cytokine levels in the serum and brain. In addition to studying LPS-induced neuroinflammation, we tested whether sickness could be separated from depressive-like behavior by evaluating LPS-treated mice in a panel of behavioral paradigms. Our behavioral data indicate that systemic LPS administration caused sickness and mild depressive-like behavior. However, due to the overlapping time course and mild effects on depression-related behavior per se, it was not possible to separate sickness from depressive-like behavior in the present rodent model. PMID:23935246

  6. Improper activation of D1 and D2 receptors leads to excess noise in prefrontal cortex

    PubMed Central

    Avery, Michael C.; Krichmar, Jeffrey L.

    2015-01-01

    The dopaminergic system has been shown to control the amount of noise in the prefrontal cortex (PFC) and likely plays an important role in working memory and the pathophysiology of schizophrenia. We developed a model that takes into account the known receptor distributions of D1 and D2 receptors, the changes these receptors have on neuron response properties, as well as identified circuitry involved in working memory. Our model suggests that D1 receptor under-stimulation in supragranular layers gates internal noise into the PFC leading to cognitive symptoms as has been proposed in attention disorders, while D2 over-stimulation gates noise into the PFC by over-activation of cortico-striatal projecting neurons in infragranular layers. We apply this model in the context of a memory-guided saccade paradigm and show deficits similar to those observed in schizophrenic patients. We also show set-shifting impairments similar to those observed in rodents with D1 and D2 receptor manipulations. We discuss how the introduction of noise through changes in D1 and D2 receptor activation may account for many of the symptoms of schizophrenia depending on where this dysfunction occurs in the PFC. PMID:25814948

  7. Piezoelectric Active Humidity Sensors Based on Lead-Free NaNbO3 Piezoelectric Nanofibers

    PubMed Central

    Gu, Li; Zhou, Di; Cao, Jun Cheng

    2016-01-01

    The development of micro-/nano-scaled energy harvesters and the self-powered sensor system has attracted great attention due to the miniaturization and integration of the micro-device. In this work, lead-free NaNbO3 piezoelectric nanofibers with a monoclinic perovskite structure were synthesized by the far-field electrospinning method. The flexible active humidity sensors were fabricated by transferring the nanofibers from silicon to a soft polymer substrate. The sensors exhibited outstanding piezoelectric energy-harvesting performance with output voltage up to 2 V during the vibration process. The output voltage generated by the NaNbO3 sensors exhibited a negative correlation with the environmental humidity varying from 5% to 80%, where the peak-to-peak value of the output voltage generated by the sensors decreased from 0.40 to 0.07 V. The sensor also exhibited a short response time, good selectively against ethanol steam, and great temperature stability. The piezoelectric active humidity sensing property could be attributed to the increased leakage current in the NaNbO3 nanofibers, which was generated due to proton hopping among the H3O+ groups in the absorbed H2O layers under the driving force of the piezoelectric potential. PMID:27338376

  8. Microbial communication leading to the activation of silent fungal secondary metabolite gene clusters

    PubMed Central

    Netzker, Tina; Fischer, Juliane; Weber, Jakob; Mattern, Derek J.; König, Claudia C.; Valiante, Vito; Schroeckh, Volker; Brakhage, Axel A.

    2015-01-01

    Microorganisms form diverse multispecies communities in various ecosystems. The high abundance of fungal and bacterial species in these consortia results in specific communication between the microorganisms. A key role in this communication is played by secondary metabolites (SMs), which are also called natural products. Recently, it was shown that interspecies “talk” between microorganisms represents a physiological trigger to activate silent gene clusters leading to the formation of novel SMs by the involved species. This review focuses on mixed microbial cultivation, mainly between bacteria and fungi, with a special emphasis on the induced formation of fungal SMs in co-cultures. In addition, the role of chromatin remodeling in the induction is examined, and methodical perspectives for the analysis of natural products are presented. As an example for an intermicrobial interaction elucidated at the molecular level, we discuss the specific interaction between the filamentous fungi Aspergillus nidulans and Aspergillus fumigatus with the soil bacterium Streptomyces rapamycinicus, which provides an excellent model system to enlighten molecular concepts behind regulatory mechanisms and will pave the way to a novel avenue of drug discovery through targeted activation of silent SM gene clusters through co-cultivations of microorganisms. PMID:25941517

  9. Maternal Immune Activation Leads to Selective Functional Deficits in Offspring Parvalbumin Interneurons

    PubMed Central

    Canetta, Sarah; Bolkan, Scott; Padilla-Coreano, Nancy; Song, LouJin; Sahn, Ryan; Harrison, Neil; Gordon, Joshua A.; Brown, Alan; Kellendonk, Christoph

    2015-01-01

    Summary Abnormalities in prefrontal GABAergic transmission, particularly in fast-spiking interneurons that express parvalbumin (PV), are hypothesized to contribute to the pathophysiology of multiple psychiatric disorders including schizophrenia, bipolar disorder, anxiety disorders and depression. While primarily histological abnormalities have been observed in patients and in animal models of psychiatric disease, evidence for abnormalities in functional neurotransmission at the level of specific interneuron populations has been lacking in animal models and is difficult to establish in human patients. Using an animal model of a psychiatric disease risk factor, prenatal maternal immune activation (MIA), we found reduced functional GABAergic transmission in the medial prefrontal cortex (mPFC) of adult MIA offspring. Decreased transmission was selective for interneurons expressing PV, and was not observed in calretinin-expressing neurons. This deficit in PV function in MIA offspring was associated with increased anxiety-like behavior and impairments in attentional set shifting, but did not affect working memory. Furthermore, cell-type specific optogenetic inhibition of mPFC PV interneurons was sufficient to impair attentional set shifting and enhance anxiety levels. Finally, we found that in vivo mPFC gamma oscillations, which are supported by PV interneuron function, were linearly correlated with the degree of anxiety displayed in adult mice, and that this correlation was disrupted in MIA offspring. These results demonstrate a selective functional vulnerability of PV interneurons to maternal immune activation, leading to affective and cognitive symptoms that have high relevance for schizophrenia and other psychiatric disorders. PMID:26830140

  10. Reverse evolution leads to genotypic incompatibility despite functional and active site convergence

    PubMed Central

    Kaltenbach, Miriam; Jackson, Colin J; Campbell, Eleanor C; Hollfelder, Florian; Tokuriki, Nobuhiko

    2015-01-01

    Understanding the extent to which enzyme evolution is reversible can shed light on the fundamental relationship between protein sequence, structure, and function. Here, we perform an experimental test of evolutionary reversibility using directed evolution from a phosphotriesterase to an arylesterase, and back, and examine the underlying molecular basis. We find that wild-type phosphotriesterase function could be restored (>104-fold activity increase), but via an alternative set of mutations. The enzyme active site converged towards its original state, indicating evolutionary constraints imposed by catalytic requirements. We reveal that extensive epistasis prevents reversions and necessitates fixation of new mutations, leading to a functionally identical sequence. Many amino acid exchanges between the new and original enzyme are not tolerated, implying sequence incompatibility. Therefore, the evolution was phenotypically reversible but genotypically irreversible. Our study illustrates that the enzyme's adaptive landscape is highly rugged, and different functional sequences may constitute separate fitness peaks. DOI: http://dx.doi.org/10.7554/eLife.06492.001 PMID:26274563

  11. Piezoelectric Active Humidity Sensors Based on Lead-Free NaNbO₃ Piezoelectric Nanofibers.

    PubMed

    Gu, Li; Zhou, Di; Cao, Jun Cheng

    2016-01-01

    The development of micro-/nano-scaled energy harvesters and the self-powered sensor system has attracted great attention due to the miniaturization and integration of the micro-device. In this work, lead-free NaNbO₃ piezoelectric nanofibers with a monoclinic perovskite structure were synthesized by the far-field electrospinning method. The flexible active humidity sensors were fabricated by transferring the nanofibers from silicon to a soft polymer substrate. The sensors exhibited outstanding piezoelectric energy-harvesting performance with output voltage up to 2 V during the vibration process. The output voltage generated by the NaNbO₃ sensors exhibited a negative correlation with the environmental humidity varying from 5% to 80%, where the peak-to-peak value of the output voltage generated by the sensors decreased from 0.40 to 0.07 V. The sensor also exhibited a short response time, good selectively against ethanol steam, and great temperature stability. The piezoelectric active humidity sensing property could be attributed to the increased leakage current in the NaNbO₃ nanofibers, which was generated due to proton hopping among the H₃O⁺ groups in the absorbed H₂O layers under the driving force of the piezoelectric potential. PMID:27338376

  12. Thermodynamic assessment of solubility and activity of iron, chromium, and nickel in lead bismuth eutectic

    NASA Astrophysics Data System (ADS)

    Gossé, Stéphane

    2014-06-01

    Lead-Bismuth Eutectic (LBE) is a heavy liquid alloy used as a coolant for the Lead-Cooled Fast Reactors and spallation target for Accelerator Driven Systems. LBE is also considered in sodium fast reactor designs as coolant in secondary circuit to avoid any occurrence of the reaction between sodium and water in steam generators. Even if this coolant presents many advantages due to its thermophysical properties, corrosion towards structural materials remains one of the major issues of LBE. Because corrosion in LBE is partly driven by dissolution processes, the solubility and chemical activity of the main elements of the alloy are the key parameters to model the related corrosion processes. Using the Calphad method and the Thermo-Calc software, a thermodynamic database was developed to assess the interaction between Cr-Ni-Fe alloys and LBE. The current thermodynamic data on the Cr-Fe-Ni + Bi-Pb quinary system was reviewed and the Bi-Cr and Cr-Pb binary phase diagrams were assessed. Fe, Cr and Ni solubilities (in at. fraction, T in K) at LBE composition were calculated: Fe solubility at LBE composition: log10 (SFe)=0.5719-4398.6T (399-1173 K) Cr solubility at LBE composition: log10 (SCr)=-0.2757-3056.1T (399-1173 K) Ni solubility at LBE composition: log10 (SNi)=2.8717-2932.9T (528-742 K) log10 (SNi)=0.2871-1006.3T (742-1173 K) Then, the thermodynamic assessment performed in this study was used to predict more accurately the Fe, Cr and Ni activities and solubilities in the case of four austenitic model alloys also studied in the framework of corrosion tests [1]. The calculated activities and solubilities provide thermodynamic data to better understand dissolution or precipitation phenomena observed during LBE corrosion processes.

  13. What Is a Good Activity for Teaching World Literature to High School Students?

    ERIC Educational Resources Information Center

    Razzano, Elaine; Baldwin, Anna E.; Cobbs, Lewis; Whitaker, Sandra; Parker, Jessica; Krajcovic, Frank J.

    2002-01-01

    Presents six educators' ideas for good activities for teaching world literature to high school students. Describes ideas, activities, and experiences with innovative ways to teach World Literature. (SG)

  14. {delta}-ALAD activity variations in red blood cells in response to lead accumulation in rock doves (Columba livia)

    SciTech Connect

    Gonzalez, M.; Tejedor, M.C.

    1992-10-01

    The enzyme {delta}-aminolevulinic acid dehydratase ({delta}-ALAD, E.C. 4.2.1.24), catalyses the second step of the haeme biosynthetic pathway and is required to maintain the haemoglobin and cytochrome content in red cells. {delta}-ALAD is not only found in bone marrow cells, the major site of haeme synthesis, but also in circulating erythrocytes and other tissues. An inverse correlation was found between {delta}-ALAD activity in red blood cells and lead concentration in the blood. The degree of {delta}-ALAD inhibition in erythrocytes has been widely accepted as a standard bioassay to detect acute and chronic lead exposure in humans and in avians. The value of this parameter as an indicator for environmental lead has been often reported in doves and Scanlon. In lead-treated rats, an increase in {delta}-ALAD activity in bone marrow cells and in blood samples was shown by radioimmunoassay at 5 and 9 days after the treatment. Similarly, the amount of {delta}-ALAD seems to be more sensitive to lead in avian species than in mammals, the usefulness of blood {delta}-ALAD activity as an index of lead exposure has already been questioned by Hutton in the pigeon and by Jaffe et al. in humans. The present investigation studied the toxic effects of lead on rock dove red blood cell {delta}-ALAD activity in two situations: in doves treated with lead acetate in the laboratory and in doves exposed to the environment of Alcala de Henares. The final lead blood concentrations were lower in the environmental than in the laboratory doves. {delta}-ALAD activity in bone marrow cells and the relationships between lead accumulation and enzyme activity in red cells, are examined. 20 refs., 5 figs., 1 tab.

  15. Examination of lead concentrations in new decorative enamel paints in four countries with different histories of activity in lead paint regulation

    SciTech Connect

    Clark, C. Scott; Kumar, Abhay; Mohapatra, Piyush; Rajankar, Prashant; Nycz, Zuleica; Hambartsumyan, Amalia; Astanina, Lydia; Roda, Sandy; Lind, Caroline; Menrath, William; Peng, Hongying

    2014-07-15

    Paints with high lead concentrations (ppm) continue to be sold around the world in many developing countries and those with economies in transition representing a major preventable environmental health hazard that is being increased as the economies expand and paint consumption is increasing. Prior lead paint testing had been performed in Brazil and India and these countries were selected to examine the impact of a new regulatory limit in Brazil and the impact of efforts of non-governmental organizations and others to stop the use of lead compounds in manufacturing paints. Armenia and Kazakhstan, in Central Asia, were selected because no information on lead concentration in those regions was available, no regulatory activities were evident and non-governmental organizations in the IPEN network were available to participate. Another objective of this research was to evaluate the lead loading (µg/cm{sup 2}) limit determined by X-Ray Fluorescence (XRF) for areas on toys that are too small to obtain a sample of sufficient size for laboratory analysis. The lead concentrations in more than three-fourths of the paints from Armenia and Kazakhstan exceeded 90 ppm, the limit in the United States, and 600 ppm, the limit in Brazil. The percentages were about one-half as high in Brazil and India. The average concentration in paints purchased in Armenia, 25,000 ppm, is among the highest that has been previously reported, that in Kazakhstan, 15,700 ppm, and India, 16,600, about median. The average concentration in Brazil, 5600 ppm, is among the lowest observed. Paints in Brazil that contained an average of 36,000 ppm before the regulatory limit became effective were below detection (<9 ppm) in samples collected in the current study. The lack of any apparent public monitoring of paint lead content as part of regulatory enforcement makes it difficult to determine whether the regulation was a major factor contributing to the decline in lead use in these paints. Using data from the

  16. 40 CFR 745.230 - Work practice standards for conducting lead-based paint activities: public and commercial...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Work practice standards for conducting lead-based paint activities: public and commercial buildings, bridges and superstructures. 745.230 Section 745.230 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT LEAD-BASED PAINT...

  17. 40 CFR 745.229 - Certification of individuals and firms engaged in lead-based paint activities: public and...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Certification of individuals and firms engaged in lead-based paint activities: public and commercial buildings, bridges and superstructures. 745.229 Section 745.229 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT LEAD-BASED...

  18. 40 CFR 745.226 - Certification of individuals and firms engaged in lead-based paint activities: target housing and...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Certification of individuals and firms engaged in lead-based paint activities: target housing and child-occupied facilities. 745.226 Section 745.226 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT LEAD-BASED PAINT POISONING PREVENTION...

  19. 75 FR 51808 - Lead-Based Paint Renovation, Repair and Painting Activities in Target Housing and Child Occupied...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-23

    ... April 22, 2008, (73 FR 21692), EPA promulgated final TSCA section 402(c)(3) regulations governing... Program are found in R23-24.6-PB-Section 14.0 of the Rhode Island Rules and Regulations For Lead Poisoning... AGENCY Lead-Based Paint Renovation, Repair and Painting Activities in Target Housing and Child...

  20. 75 FR 13127 - Lead-Based Paint Renovation, Repair and Painting Activities in Target Housing and Child Occupied...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-18

    ... Exposure Reduction. In the Federal Register dated April 22, 2008 (73 FR 21692), EPA promulgated final TSCA... AGENCY Lead-Based Paint Renovation, Repair and Painting Activities in Target Housing and Child Occupied... Action Apply to Me? This action is directed to the public in general, to entities offering Lead...

  1. Creating Novel Activated Factor XI Inhibitors through Fragment Based Lead Generation and Structure Aided Drug Design

    PubMed Central

    Fjellström, Ola; Akkaya, Sibel; Beisel, Hans-Georg; Eriksson, Per-Olof; Erixon, Karl; Gustafsson, David; Jurva, Ulrik; Kang, Daiwu; Karis, David; Knecht, Wolfgang; Nerme, Viveca; Nilsson, Ingemar; Olsson, Thomas; Redzic, Alma; Roth, Robert; Sandmark, Jenny; Tigerström, Anna; Öster, Linda

    2015-01-01

    Activated factor XI (FXIa) inhibitors are anticipated to combine anticoagulant and profibrinolytic effects with a low bleeding risk. This motivated a structure aided fragment based lead generation campaign to create novel FXIa inhibitor leads. A virtual screen, based on docking experiments, was performed to generate a FXIa targeted fragment library for an NMR screen that resulted in the identification of fragments binding in the FXIa S1 binding pocket. The neutral 6-chloro-3,4-dihydro-1H-quinolin-2-one and the weakly basic quinolin-2-amine structures are novel FXIa P1 fragments. The expansion of these fragments towards the FXIa prime side binding sites was aided by solving the X-ray structures of reported FXIa inhibitors that we found to bind in the S1-S1’-S2’ FXIa binding pockets. Combining the X-ray structure information from the identified S1 binding 6-chloro-3,4-dihydro-1H-quinolin-2-one fragment and the S1-S1’-S2’ binding reference compounds enabled structure guided linking and expansion work to achieve one of the most potent and selective FXIa inhibitors reported to date, compound 13, with a FXIa IC50 of 1.0 nM. The hydrophilicity and large polar surface area of the potent S1-S1’-S2’ binding FXIa inhibitors compromised permeability. Initial work to expand the 6-chloro-3,4-dihydro-1H-quinolin-2-one fragment towards the prime side to yield molecules with less hydrophilicity shows promise to afford potent, selective and orally bioavailable compounds. PMID:25629509

  2. 40 CFR 745.230 - Work practice standards for conducting lead-based paint activities: public and commercial...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Work practice standards for conducting lead-based paint activities: public and commercial buildings, bridges and superstructures. 745.230... commercial buildings, bridges and superstructures....

  3. 40 CFR 745.230 - Work practice standards for conducting lead-based paint activities: public and commercial...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Work practice standards for conducting lead-based paint activities: public and commercial buildings, bridges and superstructures. 745.230... commercial buildings, bridges and superstructures....

  4. 78 FR 57371 - Agency Information Collection Activities; Comment Request; Student Aid Internet Gateway (SAIG...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-18

    ... Agency Information Collection Activities; Comment Request; Student Aid Internet Gateway (SAIG) Enrollment... notice will be considered public records. Title of Collection: Student Aid Internet Gateway (SAIG...: Enrollment in the Federal Student Aid (FSA) Student Aid Internet Gateway (SAIG) allows eligible entities...

  5. Biological activities of nitidine, a potential anti-malarial lead compound

    PubMed Central

    2012-01-01

    Background Nitidine is thought to be the main active ingredient in several traditional anti-malarial remedies used in different parts of the world. The widespread use of these therapies stresses the importance of studying this molecule in the context of malaria control. However, little is known about its potential as an anti-plasmodial drug, as well as its mechanism of action. Methods In this study, the anti-malarial potential of nitidine was evaluated in vitro on CQ-sensitive and -resistant strains. The nitidine's selectivity index compared with cancerous and non-cancerous cell lines was then determined. In vivo assays were then performed, using the four-day Peter's test methodology. To gain information about nitidine's possible mode of action, its moment of action on the parasite cell cycle was studied, and its localization inside the parasite was determined using confocal microscopy. The in vitro abilities of nitidine to bind haem and to inhibit β-haematin formation were also demonstrated. Results Nitidine showed similar in vitro activity in CQ-sensitive and resistant strains, and also a satisfying selectivity index (> 10) when compared with a non-cancerous cells line. Its in vivo activity was moderate; however, no sign of acute toxicity was observed during treatment. Nitidine's moment of action on the parasite cycle showed that it could not interfere with DNA replication; this was consistent with the observation that nitidine did not localize in the nucleus, but rather in the cytoplasm of the parasite. Nitidine was able to form a 1-1 complex with haem in vitro and also inhibited β-haematin formation with the same potency as chloroquine. Conclusion Nitidine can be considered a potential anti-malarial lead compound. Its ability to complex haem and inhibit β-haematin formation suggests a mechanism of action similar to that of chloroquine. The anti-malarial activity of nitidine could therefore be improved by structural modification of this molecule to increase

  6. Using Activity Theory to Model the Taiwan Atayal Students' Classroom Mathematical Activity

    ERIC Educational Resources Information Center

    Huang, Chih-Hsien; Lin, Fou-Lai

    2013-01-01

    From the sociocultural perspective, this research utilized activity theory as the theoretical framework to analyze the influences of cultural factors for Taiwanese Atayal junior high school students' study in mathematics. The research methodology adopted grounded theory, theoretical and methodological approaches which are illustrated through…

  7. Is Active Learning Like Broccoli? Student Perceptions of Active Learning in Large Lecture Classes

    ERIC Educational Resources Information Center

    Smith, C. Veronica; Cardaciotto, LeeAnn

    2011-01-01

    Although research suggests that active learning is associated with positive outcomes (e.g., memory, test performance), use of such techniques can be difficult to implement in large lecture-based classes. In the current study, 1,091 students completed out-of-class group exercises to complement course material in an Introductory Psychology class.…

  8. Coaching Tutors to Observe and Regulate Leadership in PBL Student Teams or You Can Lead a Horse to Water but You Can't Make It Drink…

    ERIC Educational Resources Information Center

    O'Shea, Noreen; Verzat, Caroline; Raucent, Benoit; Ducarme, Delphine; Bouvy, Thérèse; Herman, Benoit

    2013-01-01

    The purpose of this paper is to investigate how PBL student teams develop specific leadership configurations when implementing interdisciplinary projects and whether or not tutors help in dealing with the group interactions that are subsequently generated. The data set was drawn from 2 cohorts of first-year students engaged in PBL activities in an…

  9. Lead Toxicity to the Performance, Viability, And Community Composition of Activated Sludge Microorganisms

    SciTech Connect

    Yuan, L; Zhi, W; Liu, YS; Karyala, S; Vikesland, PJ; Chen, X; Zhang, HS

    2015-01-20

    Lead (Pb) is a prominent toxic metal in natural and engineered systems. Current knowledge on Pb toxicity to the activated sludge has been limited to short-term (<= 24 h) toxicity. The effect of extended Pb exposure on process performance, bacterial viability, and community compositions remains unknown. We quantified the 24-h and 7-day Pb toxicity to chemical oxygen demand (COD) and NH3-N removal, bacterial viability, and community compositions using lab-scale experiments. Our results showed that 7-day toxicity was significantly higher than the short-term 24-h toxicity. Ammonia-oxidizing bacteria were more susceptible than the heterotrophs to Pb toxicity. The specific oxygen uptake rate responded quickly to Pb addition and could serve as a rapid indicator for detecting Pb pollutions. Microbial viability decreased linearly with the amount of added Pb at extended exposure. The bacterial community diversity was markedly reduced with elevated Pb concentrations. Surface analysis suggested that the adsorbed form of Pb could have contributed to its toxicity along with the dissolved form. Our study provides for the first time a systematic investigation of the effect of extended exposure of Pb on the performance and microbiology of aerobic treatment processes, and it indicates that long-term Pb toxicity has been underappreciated by previous studies.

  10. Lead toxicity to the performance, viability, and community composition of activated sludge microorganisms.

    PubMed

    Yuan, Li; Zhi, Wei; Liu, Yangsheng; Karyala, Saikumar; Vikesland, Peter J; Chen, Xi; Zhang, Husen

    2015-01-20

    Lead (Pb) is a prominent toxic metal in natural and engineered systems. Current knowledge on Pb toxicity to the activated sludge has been limited to short-term (≤24 h) toxicity. The effect of extended Pb exposure on process performance, bacterial viability, and community compositions remains unknown. We quantified the 24-h and 7-day Pb toxicity to chemical oxygen demand (COD) and NH3–N removal, bacterial viability, and community compositions using lab-scale experiments. Our results showed that 7-day toxicity was significantly higher than the short-term 24-h toxicity. Ammonia-oxidizing bacteria were more susceptible than the heterotrophs to Pb toxicity. The specific oxygen uptake rate responded quickly to Pb addition and could serve as a rapid indicator for detecting Pb pollutions. Microbial viability decreased linearly with the amount of added Pb at extended exposure. The bacterial community diversity was markedly reduced with elevated Pb concentrations. Surface analysis suggested that the adsorbed form of Pb could have contributed to its toxicity along with the dissolved form. Our study provides for the first time a systematic investigation of the effect of extended exposure of Pb on the performance and microbiology of aerobic treatment processes, and it indicates that long-term Pb toxicity has been underappreciated by previous studies. PMID:25536278

  11. Thermally Activated Point Defect Diffusion in Methylammonium Lead Trihalide: Anisotropic and Ultrahigh Mobility of Iodine.

    PubMed

    Delugas, P; Caddeo, C; Filippetti, A; Mattoni, A

    2016-07-01

    We study the diffusion of point defects in crystalline methylammonium lead halide (MAPI) at finite temperatures by using all-atoms molecular dynamics. We find that, for what concerns intrinsic defects, iodine diffusion is by far the dominant mechanism of ionic transport in MAPI, with diffusivities as high as 7.4 × 10(-7) and 4.3 × 10(-6) cm(2) s(-1) at 300 K and single activation energies of 0.24 and 0.10 eV, for interstitials and vacancies, respectively. The comparison with common covalent and oxide crystals reveals the ultrahigh mobility of defects in MAPI. Though at room temperature the vacancies are about 1 order of magnitude more diffusive, the anisotropic interstitial dynamics increases more rapidly with temperature, and it can be dominant at high temperatures. Present results are fully consistent with the involvement of iodide ions in hysteresis and have implications for improvement of the material quality by better control of defect diffusion. PMID:27237630

  12. Novel lead structures and activation mechanisms for CO-releasing molecules (CORMs).

    PubMed

    Schatzschneider, U

    2015-03-01

    Carbon monoxide (CO) is an endogenous small signalling molecule in the human body, produced by the action of haem oxygenase on haem. Since it is very difficult to apply safely as a gas, solid storage and delivery forms for CO are now explored. Most of these CO-releasing molecules (CORMs) are based on the inactivation of the CO by coordinating it to a transition metal centre in a prodrug approach. After a brief look at the potential cellular target structures of CO, an overview of the design principles and activation mechanisms for CO release from a metal coordination sphere is given. Endogenous and exogenous triggers discussed include ligand exchange reactions with medium, enzymatically-induced CO release and photoactivated liberation of CO. Furthermore, the attachment of CORMs to hard and soft nanomaterials to confer additional target specificity to such systems is critically assessed. A survey of analytical methods for the study of the stoichiometry and kinetics of CO release, as well as the tracking of CO in living systems by using fluorescent probes, concludes this review. CORMs are very valuable tools for studying CO bioactivity and might lead to new drug candidates; however, in the design of future generations of CORMs, particular attention has to be paid to their drug-likeness and the tuning of the peripheral 'drug sphere' for specific biomedical applications. Further progress in this field will thus critically depend on a close interaction between synthetic chemists and researchers exploring the physiological effects and therapeutic applications of CO. PMID:24628281

  13. A Survey of Factors and Attitudes of Students at a Rural Two-Year College Which Promote Low Participation in Student Activities Programs: An Institutional Study.

    ERIC Educational Resources Information Center

    Stolar, Steven M.

    In spring 1988, a survey was conducted of the student body at Cumberland County College (CCC) to obtain insight into students' perceptions of student activities programs at the college, the characteristics of participants in these activities, the activities students would like to see offered, and the most convenient times. A random sample of 202…

  14. A Study of Lipscomb University Students' Internet Use and Involvement in Extracurricular Activities

    ERIC Educational Resources Information Center

    Smith, Samuel Aarron

    2010-01-01

    The purpose of this study was to analyze Lipscomb University students' Internet use and involvement in extracurricular activities. A survey of students at Lipscomb University was conducted. As confirmed by the data the research was able to determine that the type of extracurricular activity a student participates in most often is related to the…

  15. Relation between Academic Performance and Students' Engagement in Digital Learning Activities

    ERIC Educational Resources Information Center

    Bertheussen, Bernt Arne; Myrland, Øystein

    2016-01-01

    This study reports on the effect of student engagement in digital learning activities on academic performance for 120 students enrolled in an undergraduate finance course. Interactive practice and exam problem files were available to each student, and individual download activity was automatically recorded during the first 50 days of the course.…

  16. Correlation between the Physical Activity Level and Grade Point Averages of Faculty of Education Students

    ERIC Educational Resources Information Center

    Imdat, Yarim

    2014-01-01

    The aim of the study is to find the correlation that exists between physical activity level and grade point averages of faculty of education students. The subjects consist of 359 (172 females and 187 males) under graduate students To determine the physical activity levels of the students in this research, International Physical Activity…

  17. University Students Meeting the Recommended Standards of Physical Activity and Body Mass Index

    ERIC Educational Resources Information Center

    Deng, Xiaofen; Castelli, Darla; Castro-Pinero, Jose; Guan, Hongwei

    2011-01-01

    This study investigated student physical activity (PA) and body mass index (BMI) in relation to the "Healthy Campus 2010" objectives set by the American College Health Association in 2002. Students (N = 1125) at a U.S. southern state university participated in the study. The percentages of students who were physically active and whose BMI were…

  18. Enhancing Student Motivation in College and University Physical Activity Courses Using Instructional Alignment Practices

    ERIC Educational Resources Information Center

    Kim, MooSong; Cardinal, Bradley J.; Yun, Joonkoo

    2015-01-01

    Motivation is a key factor in promoting students' active engagement in regular physical activity. According to self-determination theory -- one of the prominent motivational theories -- for this to occur, students' basic psychological needs must be met (i.e., their need for autonomy, competence and relatedness). Students' self-determined…

  19. Does Alcohol Use among Sexually Active College Students Moderate HIV Risk Behavior?

    ERIC Educational Resources Information Center

    Lewis, John E.; Malow, Robert M.; Norman, Lisa

    2008-01-01

    College students frequently use alcohol and are very sexually active, but do the two behaviors result in greater HIV risk? We employed the AIDS Risk Reduction Model to assess condom use during vaginal intercourse for sexually active college students using and not using alcohol proximal to sex. Students reported multiple lifetime sex partners and…

  20. Alignment of Hands-On STEM Engagement Activities with Positive STEM Dispositions in Secondary School Students

    ERIC Educational Resources Information Center

    Christensen, Rhonda; Knezek, Gerald; Tyler-Wood, Tandra

    2015-01-01

    This study examines positive dispositions reported by middle school and high school students participating in programs that feature STEM-related activities. Middle school students participating in school-to-home hands-on energy monitoring activities are compared to middle school and high school students in a different project taking part in…

  1. You Can Lead a Horse to Water: Efficacy of and Students' Perceptions of an Online Textbook Support Site

    ERIC Educational Resources Information Center

    Van Camp, Debbie; Baugh, Stacey-Ann

    2014-01-01

    An increasing number of publishers offer online companion websites that students pay to access with the expectation that using these will significantly increase their grade. This research assessed the students' attitudes toward and the efficacy of components of MyPsychLab, a companion site for Introduction to Psychology. Students reported…

  2. An Opportunity to Lead Sustainably: The Benefits and Considerations of Student-Led Green Revolving Fund Projects

    ERIC Educational Resources Information Center

    Kononenko, Kevin

    2012-01-01

    In recent years, energy- and resource-reduction projects have compelled student leaders to create sustainability projects on campuses across the country. This paper examines the role that students play in green revolving funds, including identification, approval, and management. After speaking with numerous students on a variety of campuses, it is…

  3. Promoting Physical Activity for Students with Autism Spectrum Disorder: Barriers, Benefits, and Strategies for Success

    ERIC Educational Resources Information Center

    Menear, Kristi S.; Neumeier, William H.

    2015-01-01

    Many students with autism spectrum disorder (ASD) fall short of the recommended physical activity levels and experience challenges in physical activity and physical education settings. This article reviews factors that can improve the physical activity statistics of students with ASD, outlines the researched benefits of physical activity for…

  4. Technology and Engineering Education Students' Perceptions of Hands-On and Hands-Off Activities

    ERIC Educational Resources Information Center

    Sianez, David M.; Fugere, Madeleine A.; Lennon, Carter A.

    2010-01-01

    Technology and engineering education students responded to a survey regarding hands-on and hands-off activities. First, the students listed hands-on and hands-off activities and what characterized the two types of activities. Activities such as building or assembling something as well as working manually with tools were viewed as hands-on. Passive…

  5. Activism and Leadership Development: Examining the Relationship between College Student Activism Involvement and Socially Responsible Leadership Capacity

    ERIC Educational Resources Information Center

    Page, Jeremy Dale

    2010-01-01

    The purpose of this study was to examine the relationship between participation in student activism and leadership development among college students. This study applied the social change model of leadership development (SCM) as the theoretical model used to measure socially responsible leadership capacity in students. The study utilized data…

  6. Amplifiers of Developmental and Negative Experiences in Organized Activities: Dosage, Motivation, Lead Roles, and Adult-Youth Ratios

    ERIC Educational Resources Information Center

    Hansen, David M.; Larson, Reed W.

    2007-01-01

    This study evaluated four sets of factors hypothesized to amplify adolescents' developmental and negative experience in organized youth activities. A representative sample of 1,822 eleventh grade students from 19 high schools completed the computer-administered Youth Experience Survey. Findings indicated that amount of time, motivation, holding a…

  7. Novel lead structures and activation mechanisms for CO-releasing molecules (CORMs)

    PubMed Central

    Schatzschneider, U

    2015-01-01

    Carbon monoxide (CO) is an endogenous small signalling molecule in the human body, produced by the action of haem oxygenase on haem. Since it is very difficult to apply safely as a gas, solid storage and delivery forms for CO are now explored. Most of these CO-releasing molecules (CORMs) are based on the inactivation of the CO by coordinating it to a transition metal centre in a prodrug approach. After a brief look at the potential cellular target structures of CO, an overview of the design principles and activation mechanisms for CO release from a metal coordination sphere is given. Endogenous and exogenous triggers discussed include ligand exchange reactions with medium, enzymatically-induced CO release and photoactivated liberation of CO. Furthermore, the attachment of CORMs to hard and soft nanomaterials to confer additional target specificity to such systems is critically assessed. A survey of analytical methods for the study of the stoichiometry and kinetics of CO release, as well as the tracking of CO in living systems by using fluorescent probes, concludes this review. CORMs are very valuable tools for studying CO bioactivity and might lead to new drug candidates; however, in the design of future generations of CORMs, particular attention has to be paid to their drug-likeness and the tuning of the peripheral ‘drug sphere’ for specific biomedical applications. Further progress in this field will thus critically depend on a close interaction between synthetic chemists and researchers exploring the physiological effects and therapeutic applications of CO. Linked Articles This article is part of a themed section on Pharmacology of the Gasotransmitters. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2015.172.issue-6 PMID:24628281

  8. Maternal immune activation leads to selective functional deficits in offspring parvalbumin interneurons.

    PubMed

    Canetta, S; Bolkan, S; Padilla-Coreano, N; Song, L J; Sahn, R; Harrison, N L; Gordon, J A; Brown, A; Kellendonk, C

    2016-07-01

    Abnormalities in prefrontal gamma aminobutyric acid (GABA)ergic transmission, particularly in fast-spiking interneurons that express parvalbumin (PV), are hypothesized to contribute to the pathophysiology of multiple psychiatric disorders, including schizophrenia, bipolar disorder, anxiety disorders and depression. While primarily histological abnormalities have been observed in patients and in animal models of psychiatric disease, evidence for abnormalities in functional neurotransmission at the level of specific interneuron populations has been lacking in animal models and is difficult to establish in human patients. Using an animal model of a psychiatric disease risk factor, prenatal maternal immune activation (MIA), we found reduced functional GABAergic transmission in the medial prefrontal cortex (mPFC) of adult MIA offspring. Decreased transmission was selective for interneurons expressing PV, resulted from a decrease in release probability and was not observed in calretinin-expressing neurons. This deficit in PV function in MIA offspring was associated with increased anxiety-like behavior and impairments in attentional set shifting, but did not affect working memory. Furthermore, cell-type specific optogenetic inhibition of mPFC PV interneurons was sufficient to impair attentional set shifting and enhance anxiety levels. Finally, we found that in vivo mPFC gamma oscillations, which are supported by PV interneuron function, were linearly correlated with the degree of anxiety displayed in adult mice, and that this correlation was disrupted in MIA offspring. These results demonstrate a selective functional vulnerability of PV interneurons to MIA, leading to affective and cognitive symptoms that have high relevance for schizophrenia and other psychiatric disorders. PMID:26830140

  9. Lead Adsorption into Activated Carbon: A Critical Review of the Literature

    EPA Science Inventory

    Lead has been widely used in many industries due to its desirable chemical and physical properties such as its malleability and resistance to corrosion. However, Lead poisoning is a serious health hazard that causes severe damage to multiple target organs including kidney, liver,...

  10. 24 CFR 35.1355 - Ongoing lead-based paint maintenance and reevaluation activities.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... CFR 745.227(d)(8)-(11), but only if the soil lead levels have not been previously measured. (C) The... Secretary, Department of Housing and Urban Development LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN... assessment and have the samples analyzed, in accordance with 40 CFR 745.227(b)(3)(4), but only if...

  11. 40 CFR 745.238 - Fees for accreditation and certification of lead-based paint activities.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...-certification (every 3 years, see 40 CFR 745.226(f)(7) for details) Firm $550 $550 Combined Renovation and Lead... PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN..., see 40 CFR 745.225(f)(1) for details) Initial CourseInspector Risk assessor Supervisor Worker...

  12. 40 CFR 745.238 - Fees for accreditation and certification of lead-based paint activities.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...-certification (every 3 years, see 40 CFR 745.226(f)(7) for details) Firm $550 $550 Combined Renovation and Lead... PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN..., see 40 CFR 745.225(f)(1) for details) Initial CourseInspector Risk assessor Supervisor Worker...

  13. 24 CFR 35.1355 - Ongoing lead-based paint maintenance and reevaluation activities.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... CFR 745.227(d)(8)-(11), but only if the soil lead levels have not been previously measured. (C) The... Secretary, Department of Housing and Urban Development LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN... assessment and have the samples analyzed, in accordance with 40 CFR 745.227(b)(3)(4), but only if...

  14. 24 CFR 35.1355 - Ongoing lead-based paint maintenance and reevaluation activities.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... CFR 745.227(d)(8)-(11), but only if the soil lead levels have not been previously measured. (C) The... Secretary, Department of Housing and Urban Development LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN... assessment and have the samples analyzed, in accordance with 40 CFR 745.227(b)(3)(4), but only if...

  15. 24 CFR 35.1355 - Ongoing lead-based paint maintenance and reevaluation activities.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... CFR 745.227(d)(8)-(11), but only if the soil lead levels have not been previously measured. (C) The... Secretary, Department of Housing and Urban Development LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN... assessment and have the samples analyzed, in accordance with 40 CFR 745.227(b)(3)(4), but only if...

  16. 40 CFR 745.238 - Fees for accreditation and certification of lead-based paint activities.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...-certification (every 3 years, see 40 CFR 745.226(f)(7) for details) Firm $550 $550 Combined Renovation and Lead... PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN..., see 40 CFR 745.225(f)(1) for details) Initial CourseInspector Risk assessor Supervisor Worker...

  17. 40 CFR 745.238 - Fees for accreditation and certification of lead-based paint activities.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...-certification (every 3 years, see 40 CFR 745.226(f)(7) for details) Firm $550 $550 Combined Renovation and Lead... PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN..., see 40 CFR 745.225(f)(1) for details) Initial CourseInspector Risk assessor Supervisor Worker...

  18. 24 CFR 35.1355 - Ongoing lead-based paint maintenance and reevaluation activities.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... CFR 745.227(d)(8)-(11), but only if the soil lead levels have not been previously measured. (C) The... Secretary, Department of Housing and Urban Development LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN... assessment and have the samples analyzed, in accordance with 40 CFR 745.227(b)(3)(4), but only if...

  19. 77 FR 65415 - Agency Information Collection Activities; Submission for OMB Review; Comment Request; Lead in...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-26

    ... notice published in the Federal Register on August 10, 2012 (77 FR 47882). Interested parties are...; Lead in General Industry Standard ACTION: Notice. SUMMARY: The Department of Labor (DOL) is submitting...) titled, ``Lead in General Industry Standard,'' to the Office of Management and Budget (OMB) for...

  20. 77 FR 65414 - Agency Information Collection Activities; Submission for OMB Review; Comment Request; Lead in...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-26

    ... published in the Federal Register on August 10, 2012 (77 FR 47883). Interested parties are encouraged to...; Lead in Construction Standard ACTION: Notice. SUMMARY: The Department of Labor (DOL) is submitting the..., ``Lead in Construction Standard,'' to the Office of Management and Budget (OMB) for review and...

  1. ACTIVATION OF B-CATENIN SIGNALLING LEADS TO TEMPOROMANDIBULAR JOINT DEFECTS

    PubMed Central

    Wang, M.; Li, S.; Xie, W.; Shen, J.; Im, H-J.; Holz, J.D.; Wang, M.; Diekwisch, T.G.H.; Chen, D.

    2014-01-01

    Despite extensive research in knee and hip osteoarthritis (OA), the underlying mechanism of temporomandibular joint (TMJ) disorder remains largely unknown. The purpose of this study was to determine whether the constitutive activation of β-catenin in the middle and deep layers of the articular cartilage can compromise the homeostasis of this tissue in the TMJ. Co12CreERT2 transgenic mice were bred with RosamT/mG reporter mice to determine Cre recombination efficiency. Co12CreERT2 mice were then crossed with β-cateninflox (ex3)/+ mice to generate β-catenin conditional activation mice, β-catenin(ex3)Co12ER. TMJ samples were harvested when the mice were 1-, 3- or 6-month-old and evaluated using histology, histomorphometry and immunohistochemistry. β-catenin(ex3)Co12ER mice were further crossed with Mmp13flox/flox and Adamts5−/− mice to generate β-catenin(ex3)/Mmp13)Co12ER and β-catenin(ex3)Co12ER)/Adamts5−/− double mutant mice to investigate the role of Mmp13 and Adamts5 in the development of TMJ disorder. High levels of Cre-recombination were seen in Co12CreERT2;RosamT/mG mice. Progressive TMJ defects developed in 1-, 3- and 6-month-old β-catenin(ex3)Co12ER mice, as revealed by histology and histomorphometry. Results further demonstrated that the defects observed in β-catenin(ex3)Co12ER mice were significantly decelerated after deletion of the Mmp13 or Adamts5 gene in (β-catenin(ex3)/Mmp13)co12ER or β-catenin(ex3)Co12ER/ Adamts5−/− double mutant mice. In summary, we found that β-catenin is a critical gene in the induction of TMJ cartilage degeneration, and over-expressing β-catenin in TMJ cartilage leads to defects assembling an OA-like phenotype. Deletion of Mmp13 and Adamts5 in β-catenin(ex3)Co12ER mice ameliorates the development of TMJ defects. This study suggests that Mmp13 and Adamts5 could be potential therapeutic targets for the treatment of TMJ disorders. PMID:25340802

  2. Activation of β-catenin signalling leads to temporomandibular joint defects.

    PubMed

    Wang, M; Li, S; Xie, W; Shen, J; Im, H J; Holz, J D; Wang, M; Diekwisch, T G; Chen, D

    2014-01-01

    Despite extensive research in knee and hip osteoarthritis (OA), the underlying mechanism of temporomandibular joint (TMJ) disorder remains largely unknown. The purpose of this study was to determine whether the constitutive activation of β-catenin in the middle and deep layers of the articular cartilage can compromise the homeostasis of this tissue in the TMJ. Col2CreERT2 transgenic mice were bred with RosamT/mG reporter mice to determine Cre recombination efficiency. Col2CreERT2 mice were then crossed with β-cateninflox(ex3)+ mice to generate β-catenin conditional activation mice, β-catenin(ex3)Col2ER. TMJ samples were harvested when the mice were 1-, 3- or 6-month-old and evaluated using histology, histomorphometry and immunohistochemistry. β-catenin(ex3)Col2ER mice were further crossed with Mmp13flox/flox and Adamts5-/- mice to generate (β-catenin(ex3)/Mmp13)Col2ER and β-catenin(ex3)Col2ER)/Adamts5-/- double mutant mice to investigate the role of Mmp13 and Adamts5 in the development of TMJ disorder. High levels of Cre-recombination were seen in Col2CreERT2;RosamT/mGmice. Progressive TMJ defects developed in 1-, 3- and 6-month-old β-catenin(ex3)Col2ER mice, as revealed by histology and histomorphometry. Results further demonstrated that the defects observed in β-catenin(ex3)Col2ER mice were significantly decelerated after deletion of the Mmp13 or Adamts5 gene in (β-catenin(ex3)/Mmp13)Col2ER or β-catenin(ex3)Col2ER/Adamts5-/- double mutant mice. In summary, we found that β-catenin is a critical gene in the induction of TMJ cartilage degeneration, and over-expressing β-catenin in TMJ cartilage leads to defects assembling an OA-like phenotype. Deletion of Mmp13 and Adamts5 in β-catenin(ex3)Col2ER mice ameliorates the development of TMJ defects. This study suggests that Mmp13 and Adamts5 could be potential therapeutic targets for the treatment of TMJ disorders. PMID:25340802

  3. An Examination of Faculty and Student Online Activity: Predictive Relationships of Student Academic Success in a Learning Management System (LMS)

    ERIC Educational Resources Information Center

    Stamm, Randy Lee

    2013-01-01

    The purpose of this mixed method research study was to examine relationships in student and instructor activity logs and student performance benchmarks specific to enabling early intervention by the instructor in a Learning Management System (LMS). Instructor feedback was collected through a survey instrument to demonstrate perceived importance of…

  4. The Effect of Active Student Responding during Computer-Assisted Instruction on Social Studies Learning by Students with Learning Disabilities

    ERIC Educational Resources Information Center

    Jerome, Annamaria; Barbetta, Patricia M.

    2005-01-01

    An alternating treatments design with a best treatments phase was used to compare two active student response (ASR) conditions and one on-task (OT) condition on the acquisition and maintenance of social studies facts during computer-assisted instruction. Each week for six weeks, five students were provided daily computer-assisted instruction on 21…

  5. Tertiary Students and Social Development: An Area for Direct Action--Student Rural Service Activities in Malaysia.

    ERIC Educational Resources Information Center

    Kong, Kee Poo

    The study is a survey of the different kinds of voluntary rural service (service-learning) corps of students from the institutions of higher education in Malaysia. The history, organization, and activities of the service corps are examined, and this type of student social action is viewed with reference to the role of higher education in the…

  6. Enabling the (3 + 2) cycloaddition reaction in assembling newer anti-tubercular lead acting through the inhibition of the gyrase ATPase domain: lead optimization and structure activity profiling.

    PubMed

    Jeankumar, Variam Ullas; Reshma, Rudraraju Srilakshmi; Janupally, Renuka; Saxena, Shalini; Sridevi, Jonnalagadda Padma; Medapi, Brahmam; Kulkarni, Pushkar; Yogeeswari, Perumal; Sriram, Dharmarajan

    2015-02-28

    DNA gyrase, the sole type II topoisomerase present in Mycobacterium tuberculosis, is absent in humans and is a well validated target for anti-tubercular drug discovery. In this study, a moderately active inhibitor of Mycobacterium tuberculosis GyrB, the pharmaceutically unexploited domain of DNA gyrase, was reengineered using a combination of molecular docking and medicinal chemistry strategies to obtain a lead series displaying considerable in vitro enzyme efficacy and bacterial kill against the Mycobacterium tuberculosis H37Rv strain. Biophysical investigations using differential scanning fluorimetry experiments re-ascertained the affinity of these molecules towards the GyrB domain. Furthermore, the molecules were completely devoid of hERG toxicity up to 30 μM, as evaluated in a zebra fish model with a good selectivity index, and from a pharmaceutical point of view, turned out as potential candidates against TB. PMID:25569565

  7. Correlates of college students' physical activity: cross-cultural differences.

    PubMed

    Seo, Dong-Chul; Torabi, Mohammad R; Jiang, Nan; Fernandez-Rojas, Xinia; Park, Bock-Hee

    2009-10-01

    This study examined cross-cultural differences in personal and behavioral determinants of vigorous-intensity and moderate-intensity physical activity (PA) among college students living in distinctly different cultures, that is, the United States, Costa Rica, India, and South Korea. Participants of this study were recruited from randomly chosen public universities in the 4 countries during the 2006-2007 academic year. A total of 4685 students participated in the study (response rate 90%). Vigorous-intensity PA was measured by asking on how many of the past 7 days the participants participated in PA for at least 20 minutes that made them sweat or breathe hard. For moderate-intensity PA, participants were asked on how many of the past 7 days they participated in PA for at least 30 minutes that did not make them sweat or breathe hard. Findings indicate that whereas perceived overweight and fruit and vegetable consumption are relatively culture-free predictors of PA, gender and TV/video watching are culture-specific predictors. Binge drinking was not predictive of meeting the vigorous-intensity and moderate-intensity PA guidelines in any of the 4 countries. PMID:19661101

  8. Influence of the active mass particle suspension in electrolyte upon corrosion of negative electrode of a lead-acid battery

    NASA Astrophysics Data System (ADS)

    Kamenev, Yu.; Shtompel, G.; Ostapenko, E.; Leonov, V.

    2014-07-01

    The influence of the suspension of positive active mass particles in the electrolyte on the performance of the negative electrode in a lead-acid battery is studied. A significant increase in the rate of corrosion of the lead electrode is shown when slime particles get in contact with its surface, which may result in the rise of macro-defects on the lugs of the negative electrodes.

  9. Effects of lead shot ingestion on delta-aminolevulinic acid dehydratase activity, hemoglobin concentration, and serum chemistry in bald eagles

    USGS Publications Warehouse

    Hoffman, D.J.; Pattee, O.H.; Wiemeyer, Stanley N.; Mulhern, B.

    1981-01-01

    Lead shot ingestion by bald eagles (Haliaeetus leucocephalus) is considered to be widespread and has been implicated in the death of eagles in nature. It was recently demonstrated under experimental conditions that ingestion of as few as 10 lead shot resulted in death within 12 to 20 days. In the present study hematological responses to lead toxicity including red blood cell ALAD activity, hemoglobin concentration and 23 different blood serum chemistries were examined in five captive bald eagles that were unsuitable for rehabilitation and release. Eagles were dosed by force-feeding with 10 lead shot; they were redosed if regurgitation occurred. Red blood cell ALAD activity was inhibited by nearly 80% within 24 hours when mean blood lead concentration had increased to 0.8 parts per million (ppm). By the end of 1 week there was a significant decrease (20-25%) in hematocrit and hemoglobin, and the mean blood lead concentration was over 3 ppm. Within as little as 1-2 weeks after dosing, significant elevations in serum creatinine and serum alanine aminotransferase occurred, as well as a significant decrease in the ratio of serum aspartic aminotransferase to serum alanine aminotransferase. The mean blood lead concentration was over 5 ppm by the end of 2 weeks. These changes in serum chemistry may be indicative of kidney and liver alterations.

  10. Differential effects of chronic lead intoxication on circadian rhythm of ambulatory activity and on regional brain norepinephrine levels in rats

    SciTech Connect

    Shafiq-ur-Rehman; Khushnood-ur-Rehman; Kabir-ud-Din; Chandra, O.

    1986-01-01

    Changes in biochemical mechanisms and amine concentrations in the brain have been manifested in the form of varying disorders and abnormalities in behavior, including motor-activity, which has been proved with a number of psychoactive drugs. It has been reported that increased level of cerebral norepinephrine (NE) has been shown to be associated with motor hyper-activity, and in lead exposed rats. No study is available which could account for the pattern of changes in spontaneous ambulatory responses in an open field situation together with the steady state regional levels of NE in the brain of chronically lead exposed rats. Therefore, it seemed to be worthwhile to study the circadian rhythm of ambulatory activity and its association with NE levels in various brain regions of rats exposed to lead.

  11. Macroscopic and molecular-scale assessment of soil lead contamination impacted by seasonal dove hunting activities

    SciTech Connect

    Arai, Y.; Tappero, R.; Rick, A.R.; Saylor, T.; Faas, E. & Lanzirotti, A.

    2011-05-24

    Environmental contamination of lead (Pb) in soils and sediments poses serious threats to human and ecological health. The objective of this study is to investigate the effect of seasonal dove sports hunting activities on Pb contamination in acid forest soils. A grid sampling method was used to investigate the spatial distribution of Pb contamination in surface soils. Soils were analyzed for total metal(loid) concentration and characterized for physicochemical properties and mineralogy. Adsorption isotherm experiments were also conducted to understand the reactivity and retention capacity of Pb(II) in soils. Finally, synchrotron-based X-ray microprobe and X-ray absorption spectroscopy were used to understand the chemical speciation of Pb that controls the retention/release mechanisms of Pb in soils. There was no excessive accumulation of Pb at the site. However, the concentration of Pb in surface soils was greater than the background level (<16 mg kg{sup -1}). The contamination level of Pb was as high as 67 mg kg{sup -1} near a patch of corn field where lime was frequently applied. A microfocused X-ray microprobe analysis showed the presence of Pb pellet fragments that predominantly contain oxidized Pb(II), suggesting that oxidative dissolution was occurring in soils. Dissolved Pb(II) can be readily retained in soils up to {approx}3,600 mg kg{sup -1} via inner-sphere and outer-sphere surface complexation on carbon and aluminol functional groups of soil components, suggesting that partitioning reactions control the concentration of Pb in soil solution. The fate of Pb is likely to be controlled by (1) oxidative dissolution process of Pb(0) pellets and (2) the release of outer-sphere and/or inner-sphere Pb surface complexes in humic substances and aluminosilicate/Al oxyhydroxides. Although no remedial actions are immediately required, the long-term accumulation of Pb in soils should be carefully monitored in protecting ecosystem and water quality at the dove hunting

  12. Enhancing Student-Student Online Interaction: Exploring the Study Buddy Peer Review Activity

    ERIC Educational Resources Information Center

    Madland, Colin; Richards, Griff

    2016-01-01

    The study buddy is a learning strategy employed in a graduate distance course to promote informal peer reviewing of assignments before submission. This strategy promotes student-student interaction and helps break the social isolation of distance learning. Given the concern by Arum and Roksa (2011) that student-student interaction may be…

  13. Professional Student Organizations and Experiential Learning Activities: What Drives Student Intentions to Participate?

    ERIC Educational Resources Information Center

    Munoz, Laura; Miller, Richard; Poole, Sonja Martin

    2016-01-01

    Experiential learning theory has been referenced as a possible method for attracting and retaining members in student organizations. In a survey, undergraduate students evaluated a variety of organizational features pertaining to their intention to participate in professional student organizations. The study found that students value activities…

  14. Lead from hunting activities and its potential environmental threat to wildlife in a protected wetland in Yucatan, Mexico.

    PubMed

    Arcega-Cabrera, Flor; Noreña-Barroso, Elsa; Oceguera-Vargas, Ismael

    2014-02-01

    This study provides insights into the status of lead in the protected wetland of El Palmar, located on the northwestern littoral of the Yucatan Peninsula. This reserve is ecologically and economically important because it provides feeding and breeding habitats for many species, as well as being an ecotourism destination (especially for bird watching). Although it is a protected area, duck species are heavily hunted within the reserve during the winter. As a result, animals feeding or living in sediments could be exposed to anthropogenic lead. Total lead and its geochemical fractionated forms were measured in sediment cores from six selected sites in "El Palmar" wetland, during pre- and post-hunting seasons, to approximate the potential environmental threat (especially for benthonic living/feeding organisms). Anthropogenic lead concentrations detected in soil cores ranged from below the minimum infaunal community effect level (30.24 μg g(-1)) during the pre-hunting season, to bordering the probable infaunal community effect level (112.18 μg g(-1)) during the post-hunting season, according to SquiiRTs NOAA guidelines. Yet, these results were lower than expected based on the intensity of hunting. Consequently, this article explores the possibility that the lower than expected lead concentration in sediments results from (1) degradation of shot and transformation to soluble or particulate forms; or (2) ingestion of lead shot by benthic and other lacustrine species living in the protected area. Geochemical fractionation of lead demonstrated that in the top 6 cm of the soil column at heavily active hunting sites (EP5 and EP6), lead was associated with the lithogenic fraction (average 45 percent) and with the organic fraction (average 20 percent). Bioavailable lead (sum of lead adsorbed to the carbonates, Fe/Mn oxyhydroxides and organic fractions) in sediments was lower than 50 percent for the heavily active hunting areas and higher for the rest of the sites

  15. Does Structured Quizzing with Process Specific Feedback Lead to Learning Gains in an Active Learning Geoscience Classroom?

    NASA Astrophysics Data System (ADS)

    Palsole, S.; Serpa, L. F.

    2013-12-01

    There is a great realization that efficient teaching in the geosciences has the potential to have far reaching effects in outreach to decision and policy makers (Herbert, 2006; Manduca & Mogk, 2006). This research in turn informs educators that the geosciences by the virtue of their highly integrative nature play an important role in serving as an entry point into STEM disciplines and helping developing a new cadre of geoscientists, scientists and a general population with an understanding of science. Keeping these goals in mind we set to design introductory geoscience courses for non-majors and majors that move away from the traditional lecture models which don't necessarily contribute well to knowledge building and retention ((Handelsman et al., 2007; Hake, 1997) to a blended active learning classroom where basic concepts and didactic information is acquired online via webquests, lecturettes and virtual field trips and the face to face portions of the class are focused on problem solving exercises. The traditional way to ensure that students are prepared for the in-class activity is to have the students take a quiz online to demonstrate basic competency. In the process of redesign, we decided to leverage the technology to build quizzes that are highly structured and map to a process (formation of divergent boundaries for example) or sets of earth processes that we needed the students to know before in-class activities. The quizzes can be taken multiple times and provide process specific feedback, thus serving as a heuristic to the students to ensure they have acquired the necessary competency. The heuristic quizzes were developed and deployed over a year with the student data driving the redesign process to ensure synchronicity. Preliminary data analysis indicates a positive correlation between higher student scores on in-class application exercises and time spent on the process quizzes. An assessment of learning gains also indicate a higher degree of self

  16. Lead Poisoning Prevention Tips

    MedlinePlus

    ... CDC.gov . Lead Home Calendar of Events National Lead Poisoning Prevention Week Archived Materials CDC's Childhood Lead Poisoning Prevention Program Advisory Committee (ACCLPP) Current Activities Blood ...

  17. Sex differences in social cognitive factors and physical activity in Korean college students

    PubMed Central

    Choi, Jin Yi; Chang, Ae Kyung; Choi, Eun-Ju

    2015-01-01

    [Purpose] This study examined sex differences in physical activity and social cognitive theory factors in Korean college students. [Subjects and Methods] A cross-sectional survey of 688 college students (285 men and 403 women) in Korea was conducted using a self-reported questionnaire. [Results] There was a significant difference in the level of physical activity between male and female students. The significant predictors of physical activity for male students were physical activity goals, physical activity self-efficacy, and sitting time. Meanwhile, those for female students were perceived weight, physical activity goal, physical activity outcome expectations, and sitting time. [Conclusion] Sex differences should be considered when developing interventions to increase physical activity. PMID:26180293

  18. STEM Related After-School Program Activities and Associated Outcomes on Student Learning

    ERIC Educational Resources Information Center

    Sahin, Alpaslan; Ayar, Mehmet C.; Adiguzel, Tufan

    2014-01-01

    This study explores the characteristics of after-school program activities at a charter school in the Southeast US highlighting students' experiences with and gains from these after-school program activities. A qualitative case study design was employed to understand students' views and opinions regarding the activities and their…

  19. Lessons in Higher Education: Five Pedagogical Practices that Promote Active Learning for Faculty and Students

    ERIC Educational Resources Information Center

    Cook-Sather, Alison

    2011-01-01

    Active learning by faculty members complements and promotes active learning for students. Through The Andrew W. Mellon Teaching and Learning Institute at Bryn Mawr College, faculty members actively engage with one another and with undergraduate students positioned as pedagogical consultants to explore and to practice a wide range of pedagogies. In…

  20. Online sexual activity: cross-national comparison between United States and Peruvian college students.

    PubMed

    Velezmoro, Rodrigo; Negy, Charles; Livia, Jose

    2012-08-01

    The current generation of college students commonly uses the Internet for myriad sexually-related purposes. Yet, it has been suggested that usage of the Internet for sexual purposes might lead to psychological problems. In this study, undergraduate students from a public university in the U.S. (n = 320) and Peru (n = 251) completed questionnaires addressing their online sexual activity (OSA), psychological adjustment, and family environment and communication. Results indicated that Peruvians used the Internet significantly more than U.S. students to view sexually-explicit material (SEM), find sexual partners, and search for sex-related information. Men, irrespective of nationality, used the Internet to view SEM significantly more than women. Social support, religiosity, and erotophilia were found to moderate the relations between nationality and OSA. In absolute terms, both national groups, on average, engaged in OSA a relatively low number of hours each week. Further, no differences were found in maladjustment between those who engage in OSA and those who do not, suggesting that concerns over OSA are probably unwarranted. PMID:22083655