Science.gov

Sample records for activity learners act

  1. Facilitating Active Learner Participation.

    ERIC Educational Resources Information Center

    Rosenberg, Steven; And Others

    1992-01-01

    Project Participate has developed and implemented a model for making decisions about interventions that enhance the ability of a preschool child with severe motor disabilities to actively participate in educational programs. The effectiveness of the process in increasing child participation in play, communication, social interaction, and mobility…

  2. Examination of Learner and Situation Level Variables: Choice of Speech Act and Request Strategy by Spanish L2 Learners

    ERIC Educational Resources Information Center

    Kuriscak, Lisa

    2015-01-01

    This study focuses on variation within a group of learners of Spanish (N = 253) who produced requests and complaints via a written discourse completion task. It examines the effects of learner and situational variables on production--the effect of proficiency and addressee-gender on speech-act choice and the effect of perception of imposition on…

  3. English Language Learners and the No Child Left Behind Act of 2001

    ERIC Educational Resources Information Center

    Tran, Thu Hoang

    2009-01-01

    This literature review looks at the impacts of the No Child Left Behind Act (NCLB) of 2001 on English language learners (ELLs), educators and schools. A brief overview of the current state of English as a second language teaching for adult learners will first be described. Then the importance of the enactment of the NCLB of 2001 is mentioned. Both…

  4. Pragmatic Production of Third Language Learners of English: A Focus on Request Acts Modifiers

    ERIC Educational Resources Information Center

    Jorda, Maria Pilar Safont

    2005-01-01

    The present study examines pragmatic production of monolingual (L1 Castilian) and bilingual (L1 Catalan, L2 Castilian) learners of English in a foreign language learning context, that of the Valencian Community in Spain. We particularly focused on proficiency-level effects and on the role of the task type in the use of request acts peripheral…

  5. The Realization of the Speech Act of Refusal in Egyptian Arabic by American Learners of Arabic as a Foreign Language

    ERIC Educational Resources Information Center

    Morkus, Nader

    2009-01-01

    This study investigated how the speech act of refusal is realized in Egyptian Arabic by intermediate and advanced American learners of Arabic as a foreign language. It also compared the performance of the learners to that of native speakers of Egyptian Arabic and native speakers of American English. The study aimed to investigate the relationship…

  6. Language Learning Activities of Distance EFL Learners in the Turkish Open Education System as the Indicator of Their Learner Autonomy

    ERIC Educational Resources Information Center

    Altunay, Dilek

    2013-01-01

    This study investigates the noncompulsory language learning activities performed by a group of distance EFL learners in the Turkish Open Education System. Performance of these activities has been considered as an indicator of their learner autonomy. The data were collected through an online questionnaire and interviews. The study shows that in…

  7. Interactions between and among Heritage Language Learners and Second Language Learners during Collaborative Writing Activities: How Learners Attend to Language

    ERIC Educational Resources Information Center

    Walls, Laura

    2013-01-01

    This study investigates the dynamics in the Spanish classroom between heritage language learner (HLL) dyads, second language learner (L2L) dyads, and mixed HLL-L2L dyads. Specifically, it examines oral, written and embodied discourse that informs our understanding of how learners attend to language. Analysis for this dissertation examined…

  8. Teaching Students to Be Active Learners; The Principal's Role.

    ERIC Educational Resources Information Center

    Nelson-Nasca, Donald

    1993-01-01

    Learning is not a spectator sport but requires active learners who integrate new experiences into existing cognitive structures. Principals can help students develop self-responsibility by initiating discussions on this topic, identifying and sharing multiple learning resources for student use, and modeling uses of assignments based on mastery…

  9. Does Translation Contribute to Learners' Free Active Vocabulary?

    ERIC Educational Resources Information Center

    Asiyaban, Amir R.; Bagheri, Mohammad S.

    2012-01-01

    This research was conducted to find out whether or not using "translation" technique in vocabulary teaching would have any positive effects on the "free active" vocabulary of Iranian learners of English. To carry out the research, eighty-eight intermediate male and female students were chosen. The participants were divided into four "male…

  10. Creating Active Learners on Hawaiian Adventures through Project ALOHA.

    ERIC Educational Resources Information Center

    Sato, Claire; Anderson, Thomas; Sakuda, Katherine

    1998-01-01

    Describes an integrated curriculum project for fourth graders in a Hawaiian elementary school with a highly transient population. The project, ALOHA (Active Learners on Hawaiian Adventures) was developed to motivate students in learning about Hawaii's culture and ecosystems. Cooperation between the library media specialist, technology coordinator,…

  11. Methods for Evaluating Learner Activities with New Technologies: Guidelines for the Lab@Future Project

    ERIC Educational Resources Information Center

    Mwanza-Simwami, Daisy; Engestrom, Yrjo; Amon, Tomaz

    2009-01-01

    The task of evaluating learner activities with new technologies is becoming increasingly complex because traditional evaluation strategies do not adequately consider the unique and often dynamic characteristics of learners and activities carried out. Learner activities are largely driven by motives and relationships that exist in the context in…

  12. Acquisition of Mathematical Language: Suggestions and Activities for English Language Learners

    ERIC Educational Resources Information Center

    Cirillo, Michelle; Bruna, Katherine Richardson; Herbel-Eisenmann, Beth

    2010-01-01

    In this article, we describe aspects of mathematical language that could be problematic to English-language learners, provide recommendations for teaching English-language learners, and suggest activities intended to foster language development in mathematics. (Contains 1 figure.)

  13. Discovering Me: Music Activities for Special Learners.

    ERIC Educational Resources Information Center

    Thompson, Keith P.; And Others

    The book contains information on musical activities which were field tested in Project PASE (Program in the Arts for Special Education, Pennsylvania) classrooms with a wide range of exceptionalities from preschool age to adolescence. Activities are seen to help children become more aware of their bodies, feelings, and themselves; feel important…

  14. Learners' Perceptions of Instructional Design Practice in a Situated Learning Activity

    ERIC Educational Resources Information Center

    Woolf, Nicholas; Quinn, James

    2009-01-01

    This case study investigated learners' perceptions of value from participating in a learning activity designed to model professional instructional design practice. Learners developed instructional design products for a corporate client in the context of a classroom-based course. The findings indicate that learners perceived different kinds of…

  15. A Balancing Act: How Can Intelligent Computer-Generated Feedback Be Provided in Learner-to-Learner Interactions?

    ERIC Educational Resources Information Center

    Dickinson, Markus; Eom, Soojeong; Kang, Yunkyoung; Lee, Chong Min; Sachs, Rebecca

    2008-01-01

    Task-based synchronous computer-mediated communication (CMC) may represent an optimal psycholinguistic environment for form-meaning connections, but learners do not receive feedback from a trusted authority. Intelligent computer-assisted language learning (ICALL) provides feedback, but the encouragement of communicative interaction remains largely…

  16. Learning activism, acting with phronesis

    NASA Astrophysics Data System (ADS)

    Lee, Yew-Jin

    2015-12-01

    The article "Socio-political development of private school children mobilising for disadvantaged others" by Darren Hoeg, Natalie Lemelin, and Lawrence Bencze described a language-learning curriculum that drew on elements of Socioscientific issues and Science, Technology, Society and Environment. Results showed that with a number of enabling factors acting in concert, learning about and engagement in practical action for social justice and equity are possible. An alternative but highly compatible framework is now introduced—phronetic social research—as an action-oriented, wisdom-seeking research stance for the social sciences. By so doing, it is hoped that forms of phronetic social research can gain wider currency among those that promote activism as one of many valued outcomes of an education in science.

  17. Does Active Learning Enhance Learner Outcomes? Evidence from Discussion Participation in Online Classes

    ERIC Educational Resources Information Center

    Wilson, Bruce M.; Pollock, Philip H.; Hamann, Kerstin

    2007-01-01

    Discussion is one form of active learning, which has been linked to better learner outcomes. Little is known about the relationship between active learning through discussion and learner outcome in the online environment. Here, we construct an index of active learning online that includes the number of postings a student has read, the number of…

  18. Learners' Evaluations of Teacher-Fronted and Student-Centred Classroom Activities.

    ERIC Educational Resources Information Center

    Garrett, Peter; Shortall, Terry

    2002-01-01

    Investigates language learners beliefs about their experiences with different types of classroom activities, specifically teacher-fronted activities and student-centered pairwork activities. Discusses the usefulness of studying learners' beliefs about their learning experiences, their perceptions of affective and learning outcomes from these…

  19. How Do Distance Learners Use Activities in Self-Instructional Materials?

    ERIC Educational Resources Information Center

    Mishra, Sanjaya; Gaba, Ashok Kumar

    2001-01-01

    Presents results of a study on the use of learning activities in self-instructional materials by distance learners of the Indira Gandhi National Open University (IGNOU). It shows that learners make use of the activities extensively as they have positive perceptions about benefits of Self-Assessment Questions and Terminal Questions given in the…

  20. The Child as an Active Learner: Views, Practices, and Barriers in Chinese Early Childhood Education

    ERIC Educational Resources Information Center

    Tang, Fengling

    2006-01-01

    The Chinese view of the child is in the process of changing from the dependent child of traditional Chinese society to the child as an active learner in contemporary China. The view of the child as an active learner forces early childhood practitioners to rethink the features of the child's learning and development, individuality, and needs and…

  1. A Cross-Cultural Study of Offering Advice Speech Acts by Iranian EFL Learners and English Native Speakers: Pragmatic Transfer in Focus

    ERIC Educational Resources Information Center

    Babaie, Sherveh; Shahrokhi, Mohsen

    2015-01-01

    The purpose of the present study was to compare the speech act of offering advice as realized by Iranian EFL learners and English native speakers. The study, more specifically, attempted to find out whether there was any pragmatic transfer from Persian (L1) among Iranian EFL learners while offering advice in English. It also examined whether…

  2. Investigating Learner Attitudes toward E-Books as Learning Tools: Based on the Activity Theory Approach

    ERIC Educational Resources Information Center

    Liaw, Shu-Sheng; Huang, Hsiu-Mei

    2016-01-01

    This paper investigates the use of e-books as learning tools in terms of learner satisfaction, usefulness, behavioral intention, and learning effectiveness. Based on the activity theory approach, this research develops a research model to understand learner attitudes toward e-books in two physical sizes: 10? and 7?. Results suggest that screen…

  3. Transformational Processes and Learner Outcomes for Online Learning: An Activity Theory Case Study of Spanish Students

    ERIC Educational Resources Information Center

    Terantino, Joseph M.

    2009-01-01

    The purpose of this exploratory study was to examine the actions of online language learners from an activity theoretical perspective. It also attempted to explain how the students' learning outcomes evolved from their online learning experiences. This explanation placed an emphasis on the learners' previous experiences, defining their activity…

  4. Training Learners to Use Quizlet Vocabulary Activities on Mobile Phones in Vietnam with Facebook

    ERIC Educational Resources Information Center

    Tran, Phuong

    2016-01-01

    Mobile phone ownership among university students in Vietnam has reached almost 100%, exceeding that of Internet-capable desktop computers. This has made them increasingly popular to allow learners to carry out learning activities outside of the classroom, but some studies have suggested that learners are not always willing to engage in activities…

  5. Beginning Learners' Development of Interactional Competence: Alignment Activity

    ERIC Educational Resources Information Center

    Tecedor, Marta

    2016-01-01

    This study examined the development of interactional competence (Hall, 1993; He & Young, 1998) by beginning learners of Spanish as indexed by their use of alignment moves. Discourse analysis techniques and quantitative data analysis were used to explore how 52 learners expressed alignment and changes in participation patterns in two sets of…

  6. Older Adult Learners: A Comparison of Active and Non-Active Learners

    ERIC Educational Resources Information Center

    Sloane-Seale, Atlanta; Kops, Bill

    2007-01-01

    This paper reports on a 2004 follow-up study conducted in partnership with the University of Manitoba Continuing Education Division and local senior's organizations. The partnership was formed in 2002-03 to promote applied research on lifelong learning and older adults, develop new and complement existing educational activities, and explore new…

  7. Study Abroad and Interlanguage Pragmatic Development in Request and Apology Speech Acts among Iranian Learners

    ERIC Educational Resources Information Center

    Khorshidi, Hassan Rasouli

    2013-01-01

    This research study empirically investigated the impact of study abroad context on L2 learners' pragmatic development compared with study at home group in Iran. For the study abroad group the participants were selected from the Iranian students who registered in a six-month program in language institutes in India (Mysore) and for the study at home…

  8. Balancing Act: A Phenomenological Study of Female Adult Learners Who Successfully Persisted in Graduate Studies

    ERIC Educational Resources Information Center

    Shepherd, Jeff; Nelson, Barbara Mullins

    2012-01-01

    A study was conducted utilizing Cross' (1981) barriers to adult learning as a framework to better understand how adults successfully complete their graduate studies. Participants in the study were solicited via Facebook and LinkedIn. Three female adult learners who persisted in their graduate studies while balancing demands outside academics…

  9. Realization of Speech Acts of Refusals and Pragmatic Competence by Turkish EFL Learners

    ERIC Educational Resources Information Center

    Han, Turgay; Burgucu-Tazegül, Assiye

    2016-01-01

    The purpose of the present study is to examine a) how lower-intermediate and upper-intermediate level Turkish learners of English-as-a-foreign language (EFL) realize refusals in English, b) the differences between native and non-native speakers of English in the use of refusals, and c) if L2 proficiency affects possible pragmatic transfer or not.…

  10. Learners' Interpersonal Beliefs and Generated Feedback in an Online Role-Playing Peer-Feedback Activity: An Exploratory Study

    ERIC Educational Resources Information Center

    Ching, Yu-Hui; Hsu, Yu-Chang

    2016-01-01

    Peer feedback affords interaction and critical thinking opportunities for learners in online courses. However, various factors prevent learners from taking advantage of these promising benefits. This study explored learners' perceptions of the interpersonal factors in a role-playing peer-feedback activity, and examined the types of peer feedback…

  11. Exploring primary care activities in ACT teams.

    PubMed

    Vanderlip, Erik R; Williams, Nancy A; Fiedorowicz, Jess G; Katon, Wayne

    2014-05-01

    People with serious mental illness often receive inadequate primary and preventive care services. Federal healthcare reform endorses team-based care that provides high quality primary and preventive care to at risk populations. Assertive community treatment (ACT) teams offer a proven, standardized treatment approach effective in improving mental health outcomes for the seriously mentally ill. Much is known about the effectiveness of ACT teams in improving mental health outcomes, but the degree to which medical care needs are addressed is not established. The purpose of this study was to explore the extent to which ACT teams address the physical health of the population they serve. ACT team leaders were invited to complete an anonymous, web-based survey to explore attitudes and activities involving the primary care needs of their clients. Information was collected regarding the use of health screening tools, physical health assessments, provision of medical care and collaboration with primary care systems. Data was analyzed from 127 team leaders across the country, of which 55 completed the entire survey. Nearly every ACT team leader believed ACT teams have a role in identifying and managing the medical co-morbidities of their clientele. ACT teams report participation in many primary care activities. ACT teams are providing a substantial amount of primary and preventive services to their population. The survey suggests standardization of physical health identification, management or referral processes within ACT teams may result in improved quality of medical care. ACT teams are in a unique position to improve physical health care by virtue of having medically trained staff and frequent, close contact with their clients. PMID:24337472

  12. Active Ageing and Universities: Engaging Older Learners. Research Report

    ERIC Educational Resources Information Center

    Phillipson, Chris; Ogg, Jim

    2010-01-01

    This report reviews the engagement of older learners (defined as those aged 50 and over) in education and training with particular reference to their involvement in higher education. The ageing of populations was one of the most important trends in the 20th century and will raise major challenges in this century. Appended are: (1) Selected UK…

  13. A Development of Game-Based Learning Environment to Activate Interaction among Learners

    NASA Astrophysics Data System (ADS)

    Takaoka, Ryo; Shimokawa, Masayuki; Okamoto, Toshio

    Many studies and systems that incorporate elements such as “pleasure” and “fun” in the game to improve a learner's motivation have been developed in the field of learning environments. However, few are the studies of situations where many learners gather at a single computer and participate in a game-based learning environment (GBLE), and where the GBLE designs the learning process by controlling the interactions between learners such as competition, collaboration, and learning by teaching. Therefore, the purpose of this study is to propose a framework of educational control that induces and activates interaction between learners intentionally to create a learning opportunity that is based on the knowledge understanding model of each learner. In this paper, we explain the design philosophy and the framework of our GBLE called “Who becomes the king in the country of mathematics?” from a game viewpoint and describe the method of learning support control in the learning environment. In addition, we report the results of the learning experiment with our GBLE, which we carried out in a junior high school, and include some comments by a principal and a teacher. From the results of the experiment and some comments, we noticed that a game may play a significant role in weakening the learning relationship among students and creating new relationships in the world of the game. Furthermore, we discovered that learning support control of the GBLE has led to activation of the interaction between learners to some extent.

  14. What Does Metalinguistic Activity in Learners' Interaction during a Collaborative L2 Writing Task Look Like?

    ERIC Educational Resources Information Center

    Gutierrez, Xavier

    2008-01-01

    This article examines the metalinguistic activity that arose in the interaction of 7 groups of bilingual learners writing collaboratively in their second language (L2), English. A microanalysis of this interaction reveals that metalinguistic activity comprises 3 types of oral production: comments, speech actions, and text reformulations. Text…

  15. Discussion Activities To Increase Intercultural Communication Skills for Japanese Learners in EFL.

    ERIC Educational Resources Information Center

    Kresovich, Brant M.

    1988-01-01

    The study describes ten discussion activities designed to improve the communicative abilities of Japanese learners of English based on cultural instruction goals. The activities target intermediate and advanced students, but teachers can modify the lessons for false beginners. All exercises stress speaking and listening. They focus on topics…

  16. Learner-Centered Activities from the DVD-Format "Crouching Tiger, Hidden Dragon."

    ERIC Educational Resources Information Center

    Lin, Li-Yun

    This paper demonstrates how Taiwanese English-as-a-Second-Language (ESL) college teachers and students collaborate and negotiate to design various learner-centered activities based on the Chinese film, "Crouching Tiger, Hidden Dragon." These activities are intended to enhance students' listening and speaking abilities. The paper demonstrates eight…

  17. Putting English Language Learners on the Educational Map: The No Child Left Behind Act Implemented. Education in Focus: Urban Institute Policy Brief

    ERIC Educational Resources Information Center

    de Cohen, Clemencia Cosentino; Clewell, Beatriz Chu

    2007-01-01

    To expand knowledge about young immigrant populations and to document how the No Child Left Behind Act (NCLB) affects the education of English language learner (ELL) and limited English proficient (LEP) students, the Urban Institute was funded by the Foundation for Child Development to undertake a series of reports. This policy brief draws on this…

  18. Grade 8 to 12 Academic Growth Patterns for English Language Learners and Students with Disabilities. ACT Research Report Series, 2012 (1)

    ERIC Educational Resources Information Center

    Bassiri, Dina; Allen, Jeff

    2012-01-01

    Under the current version of the Elementary and Secondary Education Act (ESEA), public schools must show consistent improvement in achievement for all students including English language learners (ELL) and students with disabilities. The assessment of ELL students and students with disabilities can present unique challenges to schools that must…

  19. 78 FR 11965 - Agency Information Collection (Learner's Perception (LP) Survey) Activities Under OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-20

    ... AFFAIRS Agency Information Collection (Learner's Perception (LP) Survey) Activities Under OMB Review...'s Perception (LP) Survey, VA Form 10-0439. OMB Control Number: 2900-0691. Type of Review: Extension... trainees perception of their clinical experience with VA versus non-VA facilities. VA will use the data...

  20. Flipping the Classroom for English Language Learners to Foster Active Learning

    ERIC Educational Resources Information Center

    Hung, Hsiu-Ting

    2015-01-01

    This paper describes a structured attempt to integrate flip teaching into language classrooms using a WebQuest active learning strategy. The purpose of this study is to examine the possible impacts of flipping the classroom on English language learners' academic performance, learning attitudes, and participation levels. Adopting a…

  1. Active Learning for Discovery and Innovation in Criminology with Chinese Learners

    ERIC Educational Resources Information Center

    Li, Jessica C. M.; Wu, Joseph

    2015-01-01

    Whereas a great deal of literature based upon the context of Western societies has concluded criminology is an ideal discipline for active learning approach, it remains uncertain if this learning approach is applicable to Chinese learners in the discipline of criminology. This article describes and provides evidence of the benefits of using active…

  2. An Emergent Language Program Framework: Actively Involving Learners in Needs Analysis.

    ERIC Educational Resources Information Center

    Savage, William; Storer, Graeme

    1992-01-01

    Relates the experience of the staff of an aquaculture outreach program in Northeast Thailand in implementing an English for special purposes program. By actively involving learners in both the needs analysis and program design, teachers were able to adapt the program content to the requirements of the students. (15 references) (JL)

  3. Synthesizing Technology Adoption and Learners' Approaches towards Active Learning in Higher Education

    ERIC Educational Resources Information Center

    Chan, Kevin; Cheung, George; Wan, Kelvin; Brown, Ian; Luk, Green

    2015-01-01

    In understanding how active and blended learning approaches with learning technologies engagement in undergraduate education, current research models tend to undermine the effect of learners' variations, particularly regarding their styles and approaches to learning, on intention and use of learning technologies. This study contributes to further…

  4. A "Dialogic" Approach to the Design of a Transcultural Communication Classroom Activity for Multilingual Learners

    ERIC Educational Resources Information Center

    Thompson, Celia Helen

    2011-01-01

    When preparing teaching materials about communication between people from different linguistic backgrounds, many factors require consideration; these include theoretical orientation, purpose, context, educational needs, study level, as well as the cultural backgrounds of the teachers and their target learners. The classroom activity described in…

  5. Fashion Design: Designing a Learner-Active, Multi-Level High School Course

    ERIC Educational Resources Information Center

    Nelson, Diane

    2009-01-01

    A high school fashion design teacher has much in common with the ringmaster of a three-ring circus. The challenges of teaching a hands-on course are to facilitate the entire class and to meet the needs of individual students. When teaching family and consumer sciences, the goal is to have a learner-active classroom. Revamping the high school's…

  6. Cross-Language Activation in Children's Speech Production: Evidence from Second Language Learners, Bilinguals, and Trilinguals

    ERIC Educational Resources Information Center

    Poarch, Gregory J.; van Hell, Janet G.

    2012-01-01

    In five experiments, we examined cross-language activation during speech production in various groups of bilinguals and trilinguals who differed in nonnative language proficiency, language learning background, and age. In Experiments 1, 2, 3, and 5, German 5- to 8-year-old second language learners of English, German-English bilinguals,…

  7. Investigating the Use of Inquiry & Web-Based Activities with Inclusive Biology Learners

    ERIC Educational Resources Information Center

    Bodzin, Alec M.; Waller, Patricia L.; Edwards, Lana; Darlene Kale, Santoro

    2007-01-01

    A Web-integrated biology program is used to explore how to best assist inclusive high school students to learn biology with inquiry-based activities. Classroom adaptations and instructional strategies teachers may use to assist in promoting biology learning with inclusive learners are discussed.

  8. The Efficacy of Some Proposed Activities For Developing Creative Thinking of English Learners at the Preparatory Stage (Second Year)

    ERIC Educational Resources Information Center

    Bakr, Samira M.

    2004-01-01

    The purpose of this study was to examine the efficacy of some proposed activities for developing creative thinking of English learners at the preparatory stage. The current study adopted the quasi- experimental design. Two groups of English learners were randomly chosen from one of Port- Said governmental preparatory schools. The experimental…

  9. Synergy between Authentic Assessment Activities and Learner Autonomy: How Does This Promote Shared Authenticity in Online Higher Education?

    ERIC Educational Resources Information Center

    Gikandi, Joyce

    2013-01-01

    The purpose of this study was to establish whether and how authentic assessment activities and learner autonomy converged to productively engage both the teacher and learners in shared authenticity. The study employed case study methodology to investigate the phenomena within an online course in ICT designed for continuing professionals in…

  10. Active Advocacy: Working Together for Appropriate Services for Gifted Learners

    ERIC Educational Resources Information Center

    Wiskow, Kyle; Fowler, V. Dianne; Christopher, Mary M.

    2011-01-01

    The Jacob K. Javits Gifted and Talented Students Act of 1988 provided additional funding for gifted programs and research endeavors. Scholars and educators within the field recognized its passage as a true watershed moment. Despite its unquestioned impact on the lives of countless gifted students around the country, federal lawmakers routinely…

  11. Fluency-dependent cortical activation associated with speech production and comprehension in second language learners.

    PubMed

    Shimada, K; Hirotani, M; Yokokawa, H; Yoshida, H; Makita, K; Yamazaki-Murase, M; Tanabe, H C; Sadato, N

    2015-08-01

    This functional magnetic resonance imaging (fMRI) study investigated the brain regions underlying language task performance in adult second language (L2) learners. Specifically, we identified brain regions where the level of activation was associated with L2 fluency levels. Thirty Japanese-speaking adults participated in the study. All participants were L2 learners of English and had achieved varying levels of fluency, as determined by a standardized L2 English proficiency test, the Versant English Test (Pearson Education Inc., 2011). When participants performed the oral sentence building task from the production tasks administered, the dorsal part of the left inferior frontal gyrus (dIFG) showed activation patterns that differed depending on the L2 fluency levels: The more fluent the participants were, the more dIFG activation decreased. This decreased activation of the dIFG might reflect the increased automaticity of a syntactic building process. In contrast, when participants performed an oral story comprehension task, the left posterior superior temporal gyrus (pSTG) showed increased activation with higher fluency levels. This suggests that the learners with higher L2 fluency were actively engaged in post-syntactic integration processing supported by the left pSTG. These data imply that L2 fluency predicts neural resource allocation during language comprehension tasks as well as in production tasks. This study sheds light on the neural underpinnings of L2 learning by identifying the brain regions recruited during different language tasks across different modalities (production vs. comprehension). PMID:26026679

  12. Listening and Speaking Activities for Foreign Language Learners: Second Collection.

    ERIC Educational Resources Information Center

    Hendrickson, James M.

    The 30 listening and speaking activities in this collection are designed to motivate students to use foreign languages for communicating their ideas and to encourage students to be creative. The criteria for including the activities were: (1) proven effectiveness toward improving students' oral language proficiency; (2) ease of adaptability to any…

  13. Sharing a Small World: Environmental Activities for Young Learners.

    ERIC Educational Resources Information Center

    Zero Population Growth, Inc., Washington, DC.

    This booklet contains a collection of activities developed for pre-K through second grade students. All of the activities in this teacher's guide use an interdisciplinary approach and explore the human connection with all living things and their environment. Contents include: (1) "Sharing Space and Working Together"; (2) "Sharing Resources and…

  14. The effect of curricular activities on learner autonomy: the perspective of undergraduate mechanical engineering students

    NASA Astrophysics Data System (ADS)

    Duarte, M.; Leite, C.; Mouraz, A.

    2016-01-01

    This study researches how first-year engineering students perceived the influence of curricular activities on their own learning autonomy, measured with an adaptation of the Personal Responsibility Orientation to Self-direction in Learning Scale (PRO-SDLS). Participants were questioned to assess the influence of the teacher's role. The results indicate that learners' characteristics (motivation and self-efficacy) contribute more to learner autonomy (LA) than the teaching-learning transaction (control and initiative), as in the original PRO-SDLS validation. The most autonomous learners presented higher values in all LA components and dimensions, but the differences were greater in motivation and initiative. The participants with higher LA were not as dependent on the teacher, regarding assessment, the completion of classroom tasks and deadlines. Regardless of the degree of autonomy in learning, all participants viewed teachers as the main source of information. Therefore, LA plays an important role in teaching activities planning. Suggestions for adjustments and more flexible learning scenarios are formulated.

  15. Cross-language activation in children's speech production: evidence from second language learners, bilinguals, and trilinguals.

    PubMed

    Poarch, Gregory J; van Hell, Janet G

    2012-03-01

    In five experiments, we examined cross-language activation during speech production in various groups of bilinguals and trilinguals who differed in nonnative language proficiency, language learning background, and age. In Experiments 1, 2, 3, and 5, German 5- to 8-year-old second language learners of English, German-English bilinguals, German-English-Language X trilinguals, and adult German-English bilinguals, respectively, named pictures in German and in English; in Experiment 4, 6- to 8-year-old German monolinguals named pictures in German. In both language conditions, cognate status was manipulated. We found that the bidirectional cognate facilitation effect was significant in all groups except the German monolinguals (Experiment 4) and, critically, the child second language learners (Experiment 1) in whom only native language (L1) German had an effect on second language (L2) English. The findings demonstrate how the integration of languages into a child's system follows a developmental path that, at lower levels of proficiency, allows only limited cross-language activation. The results are interpreted against the backdrop of the developing language systems of the children both for early second language learners and for early bi- and trilinguals. PMID:22138311

  16. Model Eliciting Activities: Fostering 21st Century Learners

    ERIC Educational Resources Information Center

    Stohlmann, Micah

    2013-01-01

    Real world mathematical modeling activities can develop needed and valuable 21st century skills. The knowledge and skills to become adept at mathematical modeling need to develop over time and students in the elementary grades should have experiences with mathematical modeling. For this to occur elementary teachers need to have positive…

  17. Total Participation Techniques: Making Every Student an Active Learner

    ERIC Educational Resources Information Center

    Himmele, Persida; Himmele, William

    2011-01-01

    Yes, there are easy-to-use and incredibly effective alternatives to the "stand and deliver" approach to teaching that causes so many students to tune out--or even drop out. Here's your opportunity to explore dozens of ways to engage K-12 students in active learning and allow them to demonstrate the depth of their knowledge and understanding. The…

  18. Innovative Strategies for Empowering Your Students to Become Active, Responsible Learners

    NASA Astrophysics Data System (ADS)

    Hufnagel, B.

    2011-09-01

    The economy continues to sputter along, and the repercussions are now hitting hard at publicly-funded colleges and universities, with enrollment increasing and funding decreasing. Funding agencies are starting to look at retention and completion rates as a way to allocate scarce dollars. Improving these rates is also one way to increase the future stream of tuition; students who can't pass introductory classes like ASTRO101 won't enroll and pay tuition for the next level, and they won't complete their degree. So what can you, a mere professor of astronomy, do? Tired of the "What do you want me to know?" questions? Provide your students with learner-centered structures to help them learn more deeply. Do your students resist active-engagement techniques and hate group work? Share empowerment strategies for helping students become active, responsible learners who can thrive in a learner-centered environment. Do you think that it's wrong for the freshman classes to be over-crowded, yet your sophomore classes don't get enough students or don't even exist? After using the proven curriculum of On Course, college and universities across the country have improved their retention across a wide range of disciplines (http://www.OnCourseWorkshop.com/Data.htm). Experience a sample of the fun and engaging activities developed over two decades to help students (1) accept personal responsibility, (2) discover self motivation, (3) master self-management, (4) use interdependence, (5) gain self-awareness, (6) adopt lifelong learning, (7) develop emotional intelligence, and (8) believe in themselves. Since this is only a one-hour workshop, we will focus on choices one and four: to be successful, students need to see themselves as the primary cause of their outcomes and experiences and to build mutually supportive relationships in our classroom and labs. Outcomes: (1) one ASTRO101 Course-ready activity to help students accept personal responsibility; (2) one ASTRO101 Course

  19. ACT/ICAPS: Thermoplastic composite activities

    NASA Technical Reports Server (NTRS)

    Renieri, M. P.; Burpo, S. J.; Roundy, L. M.; Todd, S. M.

    1992-01-01

    McDonnell Aircraft Company (MCAIR) is teamed with Douglas Aircraft Company (DAC) under NASA's Advanced Composite Technology (ACT) initiative in a program entitled Innovative Composite Aircraft Primary Structures (ICAPS). Efforts at MCAIR have focused on the use of thermoplastic composite materials in the development of structural details associated with an advanced fighter fuselage section with applicability to transport design. Based on innovative design/manufacturing concepts for the fuselage section primary structure, elements were designed, fabricated, and structurally tested. These elements focused on key issues such as thick composite lugs and low cost forming of fastenerless, stiffener/moldline concepts. Manufacturing techniques included autoclave consideration, single diaphragm co-consolidation (SDCC), and roll-forming.

  20. JPL Activated Carbon Treatment System (ACTS) for sewage

    NASA Technical Reports Server (NTRS)

    1976-01-01

    An Activated Carbon Treatment System (ACTS) was developed for sewage treatment and is being applied to a one-million gallon per day sewage treatment pilot plant in Orange County California. Activities reported include pyrolysis and activation of carbon-sewage sludge, and activated carbon treatment of sewage to meet ocean discharge standards. The ACTS Sewage treatment operations include carbon-sewage treatment, primary and secondary clarifiers, gravity (multi-media) filter, filter press dewatering, flash drying of carbon-sewage filter cake, and sludge pyrolysis and activation. Tests were conducted on a laboratory scale, 10,000 gallon per day demonstration plant and pilot test equipment. Preliminary economic studies are favorable to the ACTS process relative to activated sludge treatment for a 175,000,000 gallon per day sewage treatment plant.

  1. The Impact of Vocabulary Enhancement Activities on Vocabulary Acquisition and Retention among Male and Female EFL Learners in Iran

    ERIC Educational Resources Information Center

    Sharafi-Nejad, Maryam; Raftari, Shohreh; Bijami, Maryam; Khavari, Zahra; Ismail, Shaik Abdul Malik Mohamed; Eng, Lin Siew

    2014-01-01

    In general, incidental vocabulary acquisition is represented as the "picking up" of new vocabularies when students are engaged in a variety of reading, listening, speaking, or writing activities. Research has shown when learners read extensively incidental vocabulary acquisition happens. Many EFL students cannot be involved in reading…

  2. MAI (Multi-Dimensional Activity Based Integrated Approach): A Strategy for Cognitive Development of the Learners at the Elementary Stage

    ERIC Educational Resources Information Center

    Basantia, Tapan Kumar; Panda, B. N.; Sahoo, Dukhabandhu

    2012-01-01

    Cognitive development of the learners is the prime task of each and every stage of our school education and its importance especially in elementary state is quite worth mentioning. Present study investigated the effectiveness of a new and innovative strategy (i.e., MAI (multi-dimensional activity based integrated approach)) for the development of…

  3. Comparison of the Effects of Reflection and Contemplation Activities on Service-Learners' Cognitive and Affective Mindfulness

    ERIC Educational Resources Information Center

    Stewart, Trae; Alrutz, Megan

    2012-01-01

    This study investigates the extent to which service-learners' mindfulness is affected by engagement in reflection (e.g., dialogue) and contemplation activities (e.g., labyrinth tracing). The results are compared within and between treatment groups, while covarying for participants' initial levels of mindfulness. While both dialogue and…

  4. From Passive to Active Learners: The "Lived Experience" of Nurses in a Specialist Nephrology Nursing Education Programme

    ERIC Educational Resources Information Center

    Bridger, Jane

    2007-01-01

    Purpose: This study aims to explore the lived experience of learning for a group of staff nurses in the Middle East, who undertook a post-registration nursing education programme in the speciality of nephrology nursing (the NNP) between 2001 and 2002. The broad-based curriculum seeks to develop the staff nurses into active learners, able to…

  5. When Are Powerful Learning Environments Effective? The Role of Learner Activities and of Students' Conceptions of Educational Technology

    ERIC Educational Resources Information Center

    Gerjets, Peter H.; Hesse, Friedrich W.

    2004-01-01

    The goal of this chapter is to outline a theoretical and empirical perspective on how learners' conceptions of educational technology might influence their learning activities and thereby determine the power of computer-based learning environments. Starting with an introduction to the concept of powerful learning environments we outline how recent…

  6. Identifying and Enhancing the Strengths of Gifted Learners, K-8: Easy-to-Use Activities and Lessons

    ERIC Educational Resources Information Center

    Maccagnano, Ann Marie

    2007-01-01

    Educators can identify children's strengths early on and gain insight into each student's unique abilities by using the numerous ideas and informal assessments in this exciting guide. Gifted and talented specialist Ann Maccagnano offers K-8 teachers challenging activities and engaging lessons to develop and nurture gifted learners' talents.…

  7. CALL and the Development of Learner Autonomy: Towards an Activity-Theoretical Perspective

    ERIC Educational Resources Information Center

    Blin, Francoise

    2004-01-01

    While the concepts and principles associated with learner autonomy underpin a broad range of CALL applications and research projects, current debates and research paradigms in CALL do not provide adequate tools and models to investigate in depth the relationship between CALL and the development of learner autonomy. This paper explores the…

  8. Elementary School EFL Learners' Vocabulary Learning: The Effects of Post-Reading Activities

    ERIC Educational Resources Information Center

    Atay, Derin; Kurt, Gokce

    2006-01-01

    As language learning involves the acquisition of thousands of words, teachers and learners alike would like to know how vocabulary learning can be fostered, especially in EFL settings where learners frequently acquire impoverished lexicons, despite years of formal study. Research indicates that reading is important but not sufficient for…

  9. Using Web-Based Instruction to Promote Active Learning: Learners' Perspectives

    ERIC Educational Resources Information Center

    Lee, Lina

    2005-01-01

    This article reports classroom research on learners' perspectives on Web-based instruction that utilizes the "Blackboard" course management system. The Web-based instruction aims to provide and support collaborative learning while fostering learners' autonomy and accountability. The article also provides a description of the course design along…

  10. The Train Has Left: The No Child Left Behind Act Leaves Black and Latino Literacy Learners Waiting at the Station

    ERIC Educational Resources Information Center

    Paul, Dierdre Glenn

    2004-01-01

    Noticeably absent from recent critiques of the No Child Left Behind Act (NCLBA) has been the inclusive exploration of the NCLBA and Reading First implications as they directly relate to black and Latino student populations. In addition, a number of opportunities have been missed to comprehensively probe the ways in which this legislation serves to…

  11. Investigative Research: How It Changes Learner Status.

    ERIC Educational Resources Information Center

    Kenny, Brian

    1993-01-01

    What matters about an educational activity is how learners respond to it. This article examines a program concerned with the learners' needs, through the expression of learners' own meanings, and advances the concept of investigative research as a suitable vehicle for more autonomous learning, through a change in learner status. (26 references)…

  12. Age Discrimination in Employment Act of 1967; A Report Covering Activities in Connection with the Act During 1969.

    ERIC Educational Resources Information Center

    Wage and Labor Standards Administration (DOL), Washington, DC.

    This annual report on the Age Discrimination in Employment Act describes activities conducted under the Act in 1969. The Act prohibits discrimination in any of the terms of employment against individuals between 40 and 65 years of age. Coverage is extended to employers of 25 or more persons in occupations for which age is not a bona fide…

  13. Impact of Consciousness-Raising Activities on Young English Language Learners' Grammar Performance

    ERIC Educational Resources Information Center

    Fatemipour, Hamidreza; Hemmati, Shiva

    2015-01-01

    Grammar Consciousness-Raising (GCR) is an approach to teaching of grammar which learners instead of being taught the given rules, experience language data. The data challenge them to rethink, restructure their existing mental grammar and construct an explicit rule to describe the grammatical feature which the data illustrate (Ellis, 2002). And…

  14. Fostering Active Processing of Instructional Explanations of Learners with High and Low Prior Knowledge

    ERIC Educational Resources Information Center

    Acuna, Santiago R.; Garcia Rodicio, Hector; Sanchez, Emilio

    2011-01-01

    Despite the potential advantages of instructional explanations, evidence indicates that they are usually ineffective. Subsequent work has shown that in order to make instructional explanations effective indeed, one successful strategy is to combine them with indications of the limitations in learners' understanding that they are intended to…

  15. Developing Learners' Second Language Communicative Competence through Active Learning: Clickers or Communicative Approach?

    ERIC Educational Resources Information Center

    Agbatogun, Alaba Olaoluwakotansibe

    2014-01-01

    The purpose of this study was to compare the impact of clickers, the communicative approach and the lecture method on the communicative competence development of learners who were taught English a second language (ESL). Ninety nine pupils from three primary schools participated in the study. Quasi-experimental non-randomised pre-test posttest…

  16. An Analysis of Spanish L2 Learners' Orientation through Activity Theory

    ERIC Educational Resources Information Center

    Tocaimaza-Hatch, C. Cecilia

    2015-01-01

    Orientation is defined as the way in which individuals view a task and the means they devise to fulfill it (Appel & Lantolf, 1994; Roebuck, 2000). This study investigated the orientation of twelve learners enrolled in a fourth-semester Spanish L2 university course through the analysis of their interactions during a collaborative…

  17. Online Social Networks as Formal Learning Environments: Learner Experiences and Activities

    ERIC Educational Resources Information Center

    Veletsianos, George; Navarrete, Cesar C.

    2012-01-01

    While the potential of social networking sites to contribute to educational endeavors is highlighted by researchers and practitioners alike, empirical evidence on the use of such sites for formal online learning is scant. To fill this gap in the literature, we present a case study of learners' perspectives and experiences in an online course…

  18. The effects of data-driven learning activities on EFL learners' writing development.

    PubMed

    Luo, Qinqin

    2016-01-01

    Data-driven learning has been proved as an effective approach in helping learners solve various writing problems such as correcting lexical or grammatical errors, improving the use of collocations and generating ideas in writing, etc. This article reports on an empirical study in which data-driven learning was accomplished with the assistance of the user-friendly BNCweb, and presents the evaluation of the outcome by comparing the effectiveness of BNCweb and a search engine Baidu which is most commonly used as reference resource by Chinese learners of English as a foreign language. The quantitative results about 48 Chinese college students revealed that the experimental group which used BNCweb performed significantly better in the post-test in terms of writing fluency and accuracy, as compared with the control group which used the search engine Baidu. However, no significant difference was found between the two groups in terms of writing complexity. The qualitative results about the interview revealed that learners generally showed a positive attitude toward the use of BNCweb but there were still some problems of using corpora in the writing process, thus the combined use of corpora and other types of reference resource was suggested as a possible way to counter the potential barriers for Chinese learners of English. PMID:27536538

  19. Activities for Challenging Gifted Learners by Increasing Complexity in the Common Core

    ERIC Educational Resources Information Center

    McKeone, Alyssa; Caruso, Lenora; Bettle, Kailyn; Chase, Ashley; Bryson, Bridget; Schneider, Jean S.; Rule, Audrey C.

    2015-01-01

    Gifted learners need opportunities for critical and creative thinking to stretch their minds and imaginations. Strategies for increasing complexity in the four core areas of language arts, mathematics, science, and social studies were addressed using the Common Core and Iowa Core Standards through several methods. Descriptive adjective object…

  20. Mathematics Learning with Multiple Solution Methods: Effects of Types of Solutions and Learners' Activity

    ERIC Educational Resources Information Center

    Große, Cornelia S.

    2014-01-01

    It is commonly suggested to mathematics teachers to present learners different methods in order to solve one problem. This so-called "learning with multiple solution methods" is also recommended from a psychological point of view. However, existing research leaves many questions unanswered, particularly concerning the effects of…

  1. Using Netbooks to Support Mobile Learners' Investigations across Activities and Places

    ERIC Educational Resources Information Center

    Gaved, Mark; Collins, Trevor; Mulholland, Paul; Kerawalla, Lucinda; Jones, Ann; Scanlon, Eileen; Littleton, Karen; Blake, Canan; Petrou, Marilena; Clough, Gill; Twiner, Alison

    2010-01-01

    We explore how small-format laptops ("netbooks") have been used within evidence-based investigations undertaken by secondary school students, to what extent these are suitable for effectively supporting learners across different locations and contexts, and their implications for open learning. Over the course of seven trials with 300 students and…

  2. Active Lessons for Active Brains: Teaching Boys and Other Experiential Learners, Grades 3-10

    ERIC Educational Resources Information Center

    James, Abigail Norfleet; Allison, Sandra Boyd; McKenzie, Caitlin Zimmerman

    2011-01-01

    If you're tired of repeating yourself to students who aren't listening, try a little less talk and a lot more action. The authors follow the best-selling "Teaching the Male Brain and Teaching the Female Brain" with this ready-to-use collection of mathematics, language arts, science, and classroom management strategies. Designed for active,…

  3. ACT-Vision: active collaborative tracking for multiple PTZ cameras

    NASA Astrophysics Data System (ADS)

    Broaddus, Christopher; Germano, Thomas; Vandervalk, Nicholas; Divakaran, Ajay; Wu, Shunguang; Sawhney, Harpreet

    2009-04-01

    We describe a novel scalable approach for the management of a large number of Pan-Tilt-Zoom (PTZ) cameras deployed outdoors for persistent tracking of humans and vehicles, without resorting to the large fields of view of associated static cameras. Our system, Active Collaborative Tracking - Vision (ACT-Vision), is essentially a real-time operating system that can control hundreds of PTZ cameras to ensure uninterrupted tracking of target objects while maintaining image quality and coverage of all targets using a minimal number of sensors. The system ensures the visibility of targets between PTZ cameras by using criteria such as distance from sensor and occlusion.

  4. Glucosinolates redox activities: can they act as antioxidants?

    PubMed

    Natella, Fausta; Maldini, Mariateresa; Leoni, Guido; Scaccini, Cristina

    2014-04-15

    Glucosinolates are a class of secondary plant metabolites particularly occurring in Cruciferae with potential health-promoting properties, as their hydrolysis products, isothiocyanates, possess chemopreventive and antioxidant activities. In the present study, we systematically studied the in vitro redox behaviour of 15 glucosinolates, by using a range of analytical methods measuring different activities: (i) radical scavenging activity toward peroxyl and toward ABTS radical (chain-breaking activity); (ii) capacity in modulating the in vitro resistance of human low-density lipoprotein (LDL) catalysed by copper (chelating and chain-breaking activity). Data obtained from different assays were compared and analysed by principal component analysis (PCA). PCA allowed us to identify a big cluster of glucosinolates (10 out 15 tested) that do not possess any antioxidant capacity; while, the other five glucosinolates showed moderate and specific antioxidant capacity. Notably, sinalbin and gluconasturtiin were highly active in scavenging ABTS radical and in protecting LDL from copper-catalysed oxidation, respectively. The overall results of this study indicate that just few glucosinolates can act as antioxidants. PMID:24295700

  5. Activity Catalog Tool (ACT) user manual, version 2.0

    NASA Technical Reports Server (NTRS)

    Segal, Leon D.; Andre, Anthony D.

    1994-01-01

    This report comprises the user manual for version 2.0 of the Activity Catalog Tool (ACT) software program, developed by Leon D. Segal and Anthony D. Andre in cooperation with NASA Ames Aerospace Human Factors Research Division, FLR branch. ACT is a software tool for recording and analyzing sequences of activity over time that runs on the Macintosh platform. It was designed as an aid for professionals who are interested in observing and understanding human behavior in field settings, or from video or audio recordings of the same. Specifically, the program is aimed at two primary areas of interest: human-machine interactions and interactions between humans. The program provides a means by which an observer can record an observed sequence of events, logging such parameters as frequency and duration of particular events. The program goes further by providing the user with a quantified description of the observed sequence, through application of a basic set of statistical routines, and enables merging and appending of several files and more extensive analysis of the resultant data.

  6. Nucleosides Accelerate Inflammatory Osteolysis, Acting as Distinct Innate Immune Activators

    PubMed Central

    Pan, George; Zheng, Rui; Yang, Pingar; Li, Yao; Clancy, John P.; Liu, Jianzhong; Feng, Xu; Garber, David A; Spearman, Paul; McDonald, Jay M

    2015-01-01

    The innate immune system and its components play an important role in the pathogenesis of inflammatory bone destruction. Blockade of inflammatory cytokines does not completely arrest bone erosion, suggesting that other mediators also may be involved in osteolysis. Previously we showed that nucleosides promote osteoclastogenesis and bone-resorption activity in the presence of receptor activator for nuclear factor κB ligand (RANKL) in vitro. The studies described here further demonstrate that selected nucleosides and nucleoside analogues accelerate bone destruction in mice immunized with collagen II alone (CII) but also further enhance bone erosion in mice immunized by collagen II plus complete Freund's adjuvant (CII + CFA). Abundant osteoclasts are accumulated in destructive joints. These data indicate that nucleosides act as innate immune activators distinct from CFA, synergistically accelerating osteoclast formation and inflammatory osteolysis. The potential roles of the surface triggering receptor expressed on myeloid cells (TREM) and the intracellular inflammasome in nucleoside-enhanced osteoclastogenesis have been studied. These observations provide new insight into the pathogenesis and underlying mechanism of bone destruction in inflammatory autoimmune osteoarthritis. PMID:21472777

  7. Using What Learners Know.

    ERIC Educational Resources Information Center

    Burns, Mary; Adams, Sharon

    2000-01-01

    This issue of "TAP into Learning" focuses on technology-assisted learning activities for students, in particular on those that use spreadsheets. Articles include: "Using What Learners Know"; "Activity: Grade 7 and 8 Math, Social Studies and Language Arts"; "Managing Growth: Collaborative Decision-Making in Urban Planning"; "Spreadsheets"; "Getting…

  8. Participatory Multimedia Learning: Engaging Learners

    ERIC Educational Resources Information Center

    Kiili, Kristian

    2005-01-01

    The purpose of this paper is to present a participatory multimedia learning model for use in designing multimedia learning environments that support an active learning process, creative participation, and learner engagement. Participatory multimedia learning can be defined as learning with systems that enable learners to produce part of the…

  9. The Effect of English Language Learner Reclassification on Student ACT Scores, High School Graduation, and Postsecondary Enrollment: Regression Discontinuity Evidence from Wisconsin

    ERIC Educational Resources Information Center

    Carlson, Deven; Knowles, Jared E.

    2016-01-01

    The recent increase in the number of students classified as English language learners (ELLs) has focused significant attention on reclassification policy, which governs the process by which ELLs move toward, and are deemed to reach, full English proficiency. In this paper, we draw on a data set containing annual individual-level records for every…

  10. Learner's Guide: Water Quality Monitoring. An Instructional Guide for the Two-Year Water Quality Monitoring Curriculum.

    ERIC Educational Resources Information Center

    Glazer, Richard B.; And Others

    This learner's guide is designed to meet the training needs for technicians involved in monitoring activities related to the Federal Water Pollution Act and the Safe Drinking Water Act. In addition it will assist technicians in learning how to perform process control laboratory procedures for drinking water and wastewater treatment plant…

  11. The Development and Evaluation of an Achievement Test for Measuring the Efficacy of Task-Based Writing Activities to Enhance Iranian EFL Learners' Reading Comprehension

    ERIC Educational Resources Information Center

    Nejad, Ferdows Mohsen; Khosravian, Fereshteh

    2014-01-01

    The present study examined the reliability of an achievement test to measure the efficacy of task-based writing activities to improve Iranian EFL learners' reading comprehension at the intermediate level in a private language institute in Ilam, Iran, namely Alefba language institute. To achieve the goal, the techniques for evaluating reliability…

  12. Effects of an Online Learning Community on Active and Reflective Learners' Learning Performance and Attitudes in a Face-to-Face Undergraduate Course

    ERIC Educational Resources Information Center

    Zhan, Zehui; Xu, Fuyin; Ye, Huiwen

    2011-01-01

    The purpose of this study was to examine the effects of an Online Learning Community (OLC) on active and reflective learners' learning performance and attitude in a face-to-face undergraduate digital design course. 814 freshmen in an introductory digital design course were randomly assigned to one of two treatments: one offered students an OLC,…

  13. The Effects of Pragmatic Consciousness-Raising Activities on the Development of Pragmatic Awareness and Use of Hearsay Evidential Markers for Learners of Japanese as a Foreign Language

    ERIC Educational Resources Information Center

    Narita, Ritsuko

    2009-01-01

    The present study investigates the effectiveness of pragmatic consciousness-raising (PCR) activities in the L2 pragmatic acquisition of hearsay evidential markers by learners of Japanese as a foreign language (JFL). PCR is essentially an inductive approach to facilitating awareness of how language forms are used appropriately in a given context.…

  14. 77 FR 1947 - Agency Information Collection Activities: Jade Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-12

    ... Act of 2008 (JADE Act) prohibits the importation of ``Burmese covered articles'' (jadeite, rubies, and articles of jewelry containing jadeite or rubies mined or extracted from Burma), and sets forth conditions for the importation of ``non-Burmese covered articles'' (jadeite, rubies, and articles of...

  15. Reaching English Language Learners

    ERIC Educational Resources Information Center

    Keenan, Suzanne

    2004-01-01

    In the authors' science classroom, students who are English Language Learners (ELL) seem to struggle less than they do with other content areas. She believes the "handson" nature of science motivates and encourages students to interact with others. This interaction spurs conversation among the students involved in the activity. If a child is…

  16. "Dealing With" Unexpected Learner Contributions in Whole Group Activities: An Examination of Novice Language Teacher Discursive Practices

    ERIC Educational Resources Information Center

    Fagan, Drew S.

    2012-01-01

    The current paper examines the discursive practices of one novice English as a Second Language (ESL) teacher "dealing with" learners' unexpected contributions in whole group classroom interactions during teacher- and learner-initiated sequences-of-talk. The study draws from two fields of research: classroom discourse studies…

  17. The First Five Years Activities Under Public Act 761 and Public Act 230--Review and Recommendations. A Report.

    ERIC Educational Resources Information Center

    New England Program in Teacher Education, Durham, NH.

    With the creation of Public Act 761 in 1967, the State of Connecticut became one of the first states to encourage a program of collaboration and parity between schools and colleges in teacher education activities. The law took advantage of the one point in teacher education where theory and practice meet: the clinical experience of supervised…

  18. Shopping [for] Power: How Adult Literacy Learners Negotiate the Marketplace

    ERIC Educational Resources Information Center

    Ozanne, Julie L.; Adkins, Natalie Ross; Sandlin, Jennifer A.

    2005-01-01

    Little empirical evidence exists on how adult literacy learners act as consumers. Yet, adult literacy programs often employ a "functional" approach to consumer education and assume that adult learners are deficient in consumer skills. Data from a qualitative study of the consumer behaviors of adult literacy learners are used to explore how adult…

  19. Exploring Shifts in Middle School Learners' Modeling Activity While Generating Drawings, Animations, and Computational Simulations of Molecular Diffusion

    NASA Astrophysics Data System (ADS)

    Wilkerson-Jerde, Michelle H.; Gravel, Brian E.; Macrander, Christopher A.

    2015-04-01

    Modeling and using technology are two practices of particular interest to K-12 science educators. These practices are inextricably linked among professionals, who engage in modeling activity with and across a variety of representational technologies. In this paper, we explore the practices of five sixth-grade girls as they generated models of smell diffusion using drawing, stop-motion animation, and computational simulation during a multi-day workshop. We analyze video, student discourse, and artifacts to address the questions: In what ways did learners' modeling practices, reasoning about mechanism, and ideas about smell shift as they worked across this variety of representational technologies? And, what supports enabled them to persist and progress in the modeling activity? We found that the girls engaged in two distinct modeling cycles that reflected persistence and deepening engagement in the task. In the first, messing about, they focused on describing and representing many ideas related to the spread of smell at once. In the second, digging in, they focused on testing and revising specific mechanisms that underlie smell diffusion. Upon deeper analysis, we found these cycles were linked to the girls' invention of "oogtom," a representational object that encapsulated many ideas from the first cycle and allowed the girls to restart modeling with the mechanistic focus required to construct simulations. We analyze the role of activity design, facilitation, and technological infrastructure in this pattern of engagement over the course of the workshop and discuss implications for future research, curriculum design, and classroom practice.

  20. The Effects of Pragmatic Consciousness-­-Raising Activities on the Learning of Speech Acts in the Beginning CFL Classroom

    ERIC Educational Resources Information Center

    Yang, Li; Zhu, Jia

    2016-01-01

    This study investigates the effects of instruction on learners' pragmatic competence by integrating pragmatic consciousness-raising (PCR) activities into a beginning-level Chinese language course during one academic semester. The study also examines the effect of integrating the PCR activities, i.e., before or after the instruction of a…

  1. Class Acts: Activities and Games for the Business Classroom.

    ERIC Educational Resources Information Center

    Villee, Pat A. Gallo; Kaser, Kenneth J.

    This collection of 30 business classroom activities is designed to help students become active thinkers and doers. It provides a variety of ways for reinforcing concepts, practicing problem-solving and critical-thinking skills, and having fun. This manual provides an objective, instructions, and a material list for each activity. Several…

  2. The Structural Challenge: A Simple Design-Based Science Activity to Foster Creativity among Kinaesthetic Learners

    ERIC Educational Resources Information Center

    Amir, Nazir; Subramaniam, R.

    2014-01-01

    A suitable way for teachers to present science content and foster creativity in less academically inclined students is by getting them to engage in design-based science activities and guiding them along the way. This study illustrates how a design-and-make activity was carried out with the aim of getting students to showcase their creativity while…

  3. Thinking Globally and Acting Locally: Environmental Education Teaching Activities.

    ERIC Educational Resources Information Center

    Mann, Lori D.; Stapp, William B.

    Provided are teaching activities related to: (1) food production and distribution; (2) energy; (3) transportation; (4) solid waste; (5) chemicals in the environment; (6) resource management; (7) pollution; (8) population; (9) world linkages; (10) endangered species; and (11) lifestyle and environment. The activities, designed to help learners…

  4. Objects prompt authentic scientific activities among learners in a museum programme

    NASA Astrophysics Data System (ADS)

    Achiam, Marianne; Simony, Leonora; Kramer Lindow, Bent Erik

    2016-04-01

    Although the scientific disciplines conduct practical work in different ways, all consider practical work as the essential way of connecting objects and phenomena with ideas and the abstract. Accordingly, practical work is regarded as central to science education as well. We investigate a practical, object-based palaeontology programme at a natural history museum to identify how palaeontological objects prompt scientific activity among upper secondary school students. We first construct a theoretical framework based on an analysis of the programme's palaeontological content. From this, we build our reference model, which considers the specimens used in the programme, possible palaeontological interpretations of these specimens, and the conditions inherent in the programme. We use the reference model to analyse the activities of programme participants, and illustrate how these activities are palaeontologically authentic. Finally, we discuss our findings, examining the mechanism by which the specimens prompt scientific activities. We also discuss our discipline-based approach, and how it allows us to positively identify participants' activities as authentic. We conclude by discussing the implications of our findings.

  5. The Effect of Curricular Activities on Learner Autonomy: The Perspective of Undergraduate Mechanical Engineering Students

    ERIC Educational Resources Information Center

    Duarte, M.; Leite, C.; Mouraz, A.

    2016-01-01

    This study researches how first-year engineering students perceived the influence of curricular activities on their own learning autonomy, measured with an adaptation of the Personal Responsibility Orientation to Self-direction in Learning Scale (PRO-SDLS). Participants were questioned to assess the influence of the teacher's role. The results…

  6. The Effect of Post-Teaching Activity Type on Vocabulary Learning of Elementary EFL Learners

    ERIC Educational Resources Information Center

    Sadeghi, Karim; Sharifi, Faranak

    2013-01-01

    Considering the significant role of vocabulary in learning a language, and teachers' great responsibility in providing opportunities to facilitate this learning, many studies have focused on the best means of achieving a good knowledge of vocabulary. This study set out to investigate the effect of four post-teaching activities, namely game,…

  7. Growing into Greatness: A Study of a Local History Group of Active-Retired Learners

    ERIC Educational Resources Information Center

    Corrigan, Trudy; Byrne, Brid; Harris, Phyllis; Lalor, Maureen; O'Connor, Maura; O'Reilly, Kathleen; Quinn, Frank; Forde, Kathleen

    2005-01-01

    Research in Canada on the learning needs of older people looked at such issues as how to cope with changes in society, the need to make a contribution and the need to be influential. The White Paper on Adult Education "Learning for Life" notes that strategies for active ageing stress the critical importance of access to learning as a key tool in…

  8. Collaborative Syntactic Priming Activities and EFL Learners' Production of Wh-questions

    ERIC Educational Resources Information Center

    McDonough, Kim; Chaikitmongkol, Wanpen

    2010-01-01

    Syntactic priming is the tendency for a speaker to produce a structure that was encountered in recent discourse and is measured by calculating how frequently speakers use the modelled structures as opposed to alternatives. Recent lab-based studies have shown that carrying out syntactic priming activities with trained interlocutors positively…

  9. Research on the Healthy Lifestyle Model, Active Ageing, and Loneliness of Senior Learners

    ERIC Educational Resources Information Center

    Hung, Jui-Ying; Lu, Kuo-Song

    2014-01-01

    Taiwan has the fastest ageing population in the world. Thus, the government and local policy makers need to formulate policies not just for the nursing and care needs of the aged. They also need to actively promote the need for lifelong learning among seniors in order to achieve elderly-friendly objectives, such as health promotion and delays in…

  10. Towards Flexible Learning for Adult Learners in Professional Contexts: An Activity-Focused Course Design

    ERIC Educational Resources Information Center

    Cornelius, Sarah; Gordon, Carole; Ackland, Aileen

    2011-01-01

    This article argues for a flexible model of learning for adults which allows them to make choices and contextualise their learning in a manner appropriate to their own professional practice whilst also developing as a member of a learning community. It presents a design based around online "learning activities" which draws on ideas of…

  11. THE MORE CAPABLE LEARNER, GRADE 6.

    ERIC Educational Resources Information Center

    HANSEN, WILLIAM; AND OTHERS

    ENRICHMENT ACTIVITIES FOR TEACHER USE WITH CAPABLE LEARNERS ARE DISCUSSED. THE TEACHER'S SECTION CONTAINS--SUGGESTIONS FOR USING PUPIL MATERIALS, CHARACTERISTICS OF THE MORE ABLE STUDENT, A CHECKLIST FOR IDENTIFYING THE MORE ABLE STUDENTS, A CHART OF ACTIVITIES FOR THE CAPABLE LEARNER, AND A LIST OF MATERIALS AVAILABLE FROM THE CURRICULUM…

  12. Turning Reluctant Learners into Inspired Learners

    ERIC Educational Resources Information Center

    Sanacore, Joseph

    2008-01-01

    Motivation is a key factor in promoting academic success, and intrinsic motivation is especially important for developing autonomous learners. Reluctant learners, in particular, benefit from intrinsic motivation that makes learning relevant to their lives. In this article, the author describes commonalities of reluctant learners and presents…

  13. 77 FR 13617 - Agency Information Collection Activities: Customs Modernization Act Recordkeeping Requirements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-07

    ... SECURITY U.S. Customs and Border Protection Agency Information Collection Activities: Customs Modernization Act Recordkeeping Requirements AGENCY: U.S. Customs and Border Protection (CBP), Department of... concerning the Customs Modernization Act Recordkeeping Requirements. This request for comment is being...

  14. Rehabilitation Services Administration Annual Report, Fiscal Year 2004: Report on Federal Activities under the "Rehabilitation Act"

    ERIC Educational Resources Information Center

    US Department of Education, 2007

    2007-01-01

    The "Rehabilitation Act of 1973," as amended (the act), provides the legislative basis for programs and activities that assist individuals with disabilities in the pursuit of gainful employment, independence, self-sufficiency and full integration into community life. This report is intended to provide a description of accomplishments and progress…

  15. 78 FR 15031 - Agency Information Collection Activities: Andean Trade Preferences Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-08

    ... SECURITY U.S. Customs and Border Protection Agency Information Collection Activities: Andean Trade Preferences Act AGENCY: U.S. Customs and Border Protection (CBP), Department of Homeland Security. ACTION: 60... Reduction Act of 1995 (Pub. L. 104-13; 44 U.S.C. 3505(c)(2)). DATES: Written comments should be received...

  16. An Active K/K-Band Antenna Array for the NASA ACTS Mobile Terminal

    NASA Technical Reports Server (NTRS)

    Tulintseff, A.; Crist, R.; Densmore, A.; Sukamto, L.

    1993-01-01

    An active K/K-band antenna array is currently under development for NASA's ACTS Mobile Terminal (AMT). The AMT task will demonstrate voice, data, and video communications to and from the AMT vehicle in Los Angeles, California, and a base station in Cleveland, Ohio, via the ACTS satellite at 30 and 20 GHz.

  17. Learner Personas in CALL

    ERIC Educational Resources Information Center

    Heift, Trude

    2007-01-01

    In examining the titles of this year's conference presentations, the author noticed quite a few papers that focus on learner-specific issues, for instance, papers that address learning styles, learner needs, personality and learning, learner modeling and, more generally, pedagogical issues that deal with individual learner differences in…

  18. What's Your Problem? Working with Learners with Challenging Behaviour. Guidance for Colleges and Other Post-16 Education Providers on Implementing the Disability Discrimination Act

    ERIC Educational Resources Information Center

    Tissot, Cathy; Macqueen, Lynn; Faraday, Sally; Maudslay, Liz; Hewitson, Chris

    2007-01-01

    This report is one of a series of resources from the project, "The Disability Act: Taking the Work Forward 2003-05," managed by the Learning and Skills Network (LSN) in partnership with NIACE and Skill, supported by the Disability Rights Commission and funded by the Learning and Skills Council. The report is a follow-up to 1998's "Ain't…

  19. Analysis of rice Act1 5' region activity in transgenic rice plants.

    PubMed Central

    Zhang, W; McElroy, D; Wu, R

    1991-01-01

    The 5' region of the rice actin 1 gene (Act1) has been developed as an efficient regulator of foreign gene expression in transgenic rice plants. To determine the pattern and level of rice Act1 5' region activity, transgenic rice plants containing the Act1 5' region fused to a bacterial beta-glucuronidase (Gus) coding sequence were generated. Two independent clonal lines of transgenic rice plants were analyzed in detail. Quantitative analysis showed that tissue from these transgenic rice plants have a level of GUS protein that represents as much as 3% of total soluble protein. We were able to demonstrate that Act1-Gus gene expression is constitutive throughout the sporophytic and gametophytic tissues of these transgenic rice plants. Plants from one transgenic line were analyzed for the segregation of GUS activity in pollen by in situ histochemical staining, and the inheritance and stability of Act1-Gus expression were assayed in subsequently derived progeny plants. PMID:1821763

  20. Morphing into Adolescents: Active Word Learning for English-Language Learners and Their Classmates in Middle School

    ERIC Educational Resources Information Center

    Kieffer, Michael J.; Lesaux, Nonie K.

    2010-01-01

    Many students arrive at middle school without the academic language skills they need to read sophisticated texts with comprehension. In particular, English language learners and students from low-income backgrounds attending underresourced, urban middle schools lack opportunities to learn the thousands of academic words they need to succeed. To…

  1. Teacher-Made Tactile Science Materials with Critical and Creative Thinking Activities for Learners Including Those with Visual Impairments

    ERIC Educational Resources Information Center

    Teske, Jolene K.; Gray, Phyllis; Kuhn, Mason A.; Clausen, Courtney K.; Smith, Latisha L.; Alsubia, Sukainah A.; Ghayoorad, Maryam; Rule, Audrey C.; Schneider, Jean Suchsland

    2014-01-01

    Gifted students with visual impairments are twice exceptional learners and may not evidence their advanced science aptitudes without appropriate accommodations for learning science. However, effective tactile science teaching materials may be easily made. Recent research has shown that when tactile materials are used with "all" students…

  2. We Are What We Do: Examining Learner-Generated Content in the Anatomy Laboratory through the Lens of Activity Theory

    ERIC Educational Resources Information Center

    Doubleday, Alison F.; Wille, Sarah J.

    2014-01-01

    Video and photography are often used for delivering content within the anatomical sciences. However, instructors typically produce these resources to provide instructional or procedural information. Although the benefits of learner-generated content have been explored within educational research, virtually no studies have investigated the use of…

  3. Guiding Learners to near Native Fluency in English through an Adaptive Programme of Activities Which Includes Phoneme and Prosody Analysis

    ERIC Educational Resources Information Center

    Lawson, Alistair; Attridge, Ann; Lapok, Paul

    2014-01-01

    Many students of English language find pronunciation difficult to master. This work in progress paper discusses an incremental and iterative approach towards developing requirements for software applications to assist learners with the perception and production of English pronunciation in terms of phonemes and prosody. It was found that prompts…

  4. Style Shifts among Japanese Learners before and after Study Abroad in Japan: Becoming Active Social Agents in Japanese

    ERIC Educational Resources Information Center

    Iwasaki, Noriko

    2010-01-01

    Previous studies on L2 Japanese sojourners often reported that learners overuse the plain style or haphazardly mix the plain and polite styles upon return. These styles, which are often associated with formal or informal contexts, also index complex social and situational meanings, and native speakers are reported to shift their styles to create…

  5. Examining Student Cognitive and Affective Engagement and Reading Instructional Activities: Spanish-Speaking English Learners' Reading Profiles

    ERIC Educational Resources Information Center

    Barber, Ana Taboada; Gallagher, Melissa; Smith, Peet; Buehl, Michelle M.; Beck, Jori S.

    2016-01-01

    Recent research has emphasized the key role of engagement in helping students succeed in school and beyond. Given the academic struggles that many English learners (ELs) face as they transition to middle school, exploring the facets of engagement in middle school ELs is needed. We established reader profiles for eight sixth grade Hispanic ELs and…

  6. Higher order thinking skills competencies required by outcomes-based education from learners.

    PubMed

    Chabeli, M M

    2006-08-01

    Outcomes-Based Education (OBE) brought about a significant paradigm shift in the education and training of learners in South Africa. OBE requires a shift from focusing on the teacher input (instruction offerings or syllabuses expressed in terms of content), to focusing on learner outcomes. OBE is moving away from 'transmission' models to constructivistic, learner-centered models that put emphasis on learning as an active process (Nieburh, 1996:30). Teachers act as facilitators and mediators of learning (Norms and Standards, Government Gazette vol 415, no 20844 of 2000). Facilitators are responsible to create the environment that is conducive for learners to construct their own knowledge, skills and values through interaction (Peters, 2000). The first critical cross-field outcome accepted by the South African Qualification Framework (SAQA) is that learners should be able to identify and solve problems by using critical and creative thinking skills. This paper seeks to explore some higher order thinking skills competencies required by OBE from learners such as critical thinking, reflective thinking, creative thinking, dialogic / dialectic thinking, decision making, problem solving and emotional intelligence and their implications in facilitating teaching and learning from the theoretical perspective. The philosophical underpinning of these higher order thinking skills is described to give direction to the study. It is recommended that a study focusing on the assessment of these intellectual concepts be made. The study may be qualitative, quantitative or mixed methods in nature (Creswell 2005). PMID:17131612

  7. Engaging Learner Support: An Investigation of Faculty-Library Collaboration to Provide Live Course-Specific Learner Support in the Online Classroom Environment

    ERIC Educational Resources Information Center

    Fields, Alison

    2014-01-01

    Collaboration between faculty and learner support can create seamless services for e-learners. Providing access to learning materials and activities with co-located tailored learner support creates an environment in which e-learners can easily access everything they need for an enhanced, supported, and more focused learning experience. The…

  8. The Development of Expert Learners in the Classroom

    ERIC Educational Resources Information Center

    Rahman, Saemah; Mahmud, Zuria; Yassin, Siti Fatimah Mohd; Amir, Ruslin; Ilias, Khadijah Wan

    2010-01-01

    The term "expert learner" refers to students who are actively engaged with the materials learned and take responsibility for their own learning. Literature reviews suggested the use of metacognitive approach to help develop students to become expert learners. Research on development of expert learners can be traced from movements that…

  9. Using Blended Learning to Increase Learner Support and Improve Retention

    ERIC Educational Resources Information Center

    Hughes, Gwyneth

    2007-01-01

    Improving retention and identifying "at risk" learners are high profile issues in higher education, and a proposed solution is to provide good learner support. Blending of online learning with classroom sessions offers the potential to use a virtual learning environment to deliver learning activities, and to support learners using a distance…

  10. The Tip of the Iceberg: Factors Affecting Learner Motivation

    ERIC Educational Resources Information Center

    Littlejohn, Andrew

    2008-01-01

    Teachers' informal discussions of learner motivation often emphasize the need to find ways to motivate learners, most usually through "fun" or "dynamic" activities. This paper starts from the assumption, however, that part of the work of the teacher is to avoid the "demotivation" of learners, and that there is a need to consider the overall…

  11. 50 CFR 80.50 - What activities are eligible for funding under the Pittman-Robertson Wildlife Restoration Act?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... AND SPORT FISH RESTORATION PROGRAM ADMINISTRATIVE REQUIREMENTS, PITTMAN-ROBERTSON WILDLIFE RESTORATION AND DINGELL-JOHNSON SPORT FISH RESTORATION ACTS Eligible Activities § 80.50 What activities...

  12. 50 CFR 80.50 - What activities are eligible for funding under the Pittman-Robertson Wildlife Restoration Act?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... AND SPORT FISH RESTORATION PROGRAM ADMINISTRATIVE REQUIREMENTS, PITTMAN-ROBERTSON WILDLIFE RESTORATION AND DINGELL-JOHNSON SPORT FISH RESTORATION ACTS Eligible Activities § 80.50 What activities...

  13. Expanded Perspectives on Autonomous Learners

    ERIC Educational Resources Information Center

    Oxford, Rebecca L.

    2015-01-01

    This paper explores two general perspectives on autonomous learners: psychological and sociocultural. These perspectives introduce a range of theoretically grounded facets of autonomous learners, facets such as the self-regulated learner, the emotionally intelligent learner, the self-determined learner, the mediated learner, the socioculturally…

  14. Pragmatics: Teaching Speech Acts

    ERIC Educational Resources Information Center

    Tatsuki, Donna H., Ed.; Houck, Noel R., Ed.

    2010-01-01

    Language teachers have long been aware of the devastating effect of learners' grammatically correct, yet situationally inappropriate spoken or written communication. This volume addresses how to raise learner awareness of pragmatic gaffs through research-based, field-tested activities such as composing e-mail requests, giving advice, making…

  15. Listening to Learners.

    ERIC Educational Resources Information Center

    Ravenhall, Mark

    This booklet looks at the role of learner feedback in the quality improvement process. It suggests how adult and community learning (ACL) providers can adapt and improve their practice to meet the needs of learners in the changed policy context. Chapter 1 explores why providers should listen to learners and finds that listening to learners…

  16. Learner and Faculty Support

    ERIC Educational Resources Information Center

    Guan, Sharon; Stanford, Daniel

    2016-01-01

    This chapter identifies effective ways to address learner and faculty support. It introduces methods for building a successful learner support system by providing sufficient resources and proactively addressing learner motivation. It also addresses effective faculty support through institutional policies, resources, training, and course…

  17. Between the Social and the Selfish: Learner Autonomy in Online Environments

    ERIC Educational Resources Information Center

    Lewis, Tim

    2013-01-01

    This paper explores what it means to be an autonomous learner in an online social context. Using distinctions originally drawn by Jürgen Habermas, it argues that classic accounts of learner autonomy as teleological action are inadequate to explain learner activity in group settings. It points out that learners in such settings display attitudes…

  18. "Sharing Time" with Young Learners

    ERIC Educational Resources Information Center

    Yazigi, Rana; Seedhouse, Paul

    2005-01-01

    Although "Sharing Time" is a popular and widespread activity in English for Young Learners (L2) classrooms around the world, there have so far been no research studies of the interaction that is generated and its relationship to learning processes. The aims of this study were to find out how interaction is organized during "Sharing…

  19. Using Computers to Motivate Learners.

    ERIC Educational Resources Information Center

    Levesque, Jeri A.

    1989-01-01

    Maintains that the use of computers in the classroom produces motivated students, empowered learners, and increased literacy. Gives an example of the computer program "The Oregon Trail" in which students participate actively in a wagon train journey from Missouri to Oregon. Urges teachers to encourage students in their mastery of computer skills.…

  20. Staff Members as Lifelong Learners.

    ERIC Educational Resources Information Center

    Stern, Joanne V.

    Based on the assumption that all community college staff members should be lifelong learners, this paper outlines the purposes and principles underlying a quality staff development program and enumerates the elements, activities, incentives, and other considerations that are necessary for the program to be successful. First, the purposes of staff…

  1. Interlanguage Pragmatics Study of Indirect Complaint among Japanese ESL Learners

    ERIC Educational Resources Information Center

    Baba, Junko

    2010-01-01

    This interlanguage pragmatics study of linguistic expressions of affect focuses on how Japanese learners of English may express themselves in an affect-laden speech act of indirect complaint. The English as a Second Language (ESL) learners' data are compared with the baseline data of native speakers of Japanese (JJ) and American English (AA). The…

  2. Pragmatic Comprehension in Learner-Native Speaker Discourse.

    ERIC Educational Resources Information Center

    Kasper, Gabriele

    1984-01-01

    Reports on a study of language learners' comprehension of speech acts and discourse functions, referred to as pragmatic comprehension. Analyzes two types of learners' pragmatic misunderstandings: their failure to distinguish between phatic talk and referential talk, and their failure to identify the intended illocutionary force of indirect speech…

  3. 77 FR 27787 - Agency Information Collection Activities: Customs Modernization Act Recordkeeping Requirements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-11

    ... collection was previously published in the Federal Register (77 FR 13617) on March 7, 2012, allowing for a 60... SECURITY U.S. Customs and Border Protection Agency Information Collection Activities: Customs Modernization Act Recordkeeping Requirements AGENCY: U.S. Customs and Border Protection, Department of...

  4. Report on Federal Activities under the Rehabilitation Act. Annual Report, Fiscal Year 2001

    ERIC Educational Resources Information Center

    US Department of Education, 2005

    2005-01-01

    The Rehabilitation Act of 1973, as amended, provides the legislative basis for programs and activities that assist individuals with disabilities in the pursuit of gainful employment, independence, self-sufficiency and full integration into community life. This report is intended to provide a description of accomplishments and progress made under…

  5. A Review of CBO's Activities in 2008 under the Unfunded Mandates Reform Act. A CBO Report

    ERIC Educational Resources Information Center

    Lex, Leo

    2009-01-01

    In this report, part of an annual series that began in 1997, the Congressional Budget Office (CBO) reviews its activities under the Unfunded Mandates Reform Act of 1995. The report covers public laws enacted and legislation considered by the Congress in 2008 that would impose federal mandates on state, local, or tribal governments or on the…

  6. 75 FR 32959 - Agency Information Collection Activities: United States-Caribbean Basin Trade Partnership Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-10

    ... information collection was previously published in the Federal Register (75 FR 15446) on March 29, 2010... SECURITY U.S. Customs and Border Protection Agency Information Collection Activities: United States-Caribbean Basin Trade Partnership Act AGENCY: U.S. Customs and Border Protection, Department of...

  7. 76 FR 40723 - Agency Information Collection Activities; Proposed Collection; Comment Request; Clean Water Act...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-11

    ... grants to States for the establishment of State Water Pollution Control Revolving Funds (SRF). The... (CWA). The 1987 Act declares that water pollution control revolving funds shall be administered by an... AGENCY Agency Information Collection Activities; Proposed Collection; Comment Request; Clean Water...

  8. Assessment of MSFCs Process for the Development and Activation of Space Act Agreement

    NASA Technical Reports Server (NTRS)

    Daugherty, Rachel

    2014-01-01

    Space Act Agreements (SAAs) are contractual agreements that NASA utilizes to form partnerships with researchers, industry, and academia to stimulate cutting-edge innovation within the science and technology communities. center dot This study assessed the current SAA development and activation process at Marshall Space Flight Center (MSFC) to determine if improvements could be implemented to increase productivity, decrease time to activation, and improve the quality of deliverables.

  9. 76 FR 2762 - Proposed Information Collection (VAAR Clause 852.236.89, Buy American Act) Activity: Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-14

    ... AFFAIRS Proposed Information Collection (VAAR Clause 852.236.89, Buy American Act) Activity: Comment... Acquisition Regulation (VAAR) Clause 852.236-89, Buy American Act. OMB Control Number: 2900-0622. Type of Review: Extension of a currently approved collection. Abstract: The Buy American Act requires that...

  10. ChIP-seq Mapping of Distant-Acting Enhancers and Their In Vivo Activities

    SciTech Connect

    Visel, Axel; Pennacchio, Len A.

    2011-06-01

    The genomic location and function of most distant-acting transcriptional enhancers in the human genome remains unknown We performed ChIP-seq for various transcriptional coactivator proteins (such as p300) directly from different embryonic mouse tissues, identifying thousands of binding sitesTransgenic mouse experiments show that p300 and other co-activator peaks are highly predictive of genomic location AND tissue-specific activity patterns of distant-acting enhancersMost enhancers are active only in one or very few tissues Genomic location of tissue-specific p300 peaks correlates with tissue-specific expression of nearby genes Most binding sites are conserved, but the global degree of conservation varies between tissues

  11. Modeling Learner Variability in CALL

    ERIC Educational Resources Information Center

    Heift, Trude

    2008-01-01

    This article describes challenges and benefits of modeling learner variability in Computer-Assisted Language Learning. We discuss the learner model of "E-Tutor," a learner model that addresses learner variability by focusing on certain aspects and/or features of the learner's interlanguage. Moreover, we introduce the concept of phrase descriptors,…

  12. Input Generation by Young Second Language Learners.

    ERIC Educational Resources Information Center

    Cathcart-Strong, Ruth L.

    1986-01-01

    Examined spontaneous communicative acts (requests for information, calls for attention, intention statements, etc.) of a group of young second-language learners and their native-speaker interlocutors in three play situations. Results showed that, while the response rate to some types of utterances was predictable, others did not generate the…

  13. Improving Learners' Research Process Skills

    NASA Astrophysics Data System (ADS)

    Quan, T. K.; Hunter, L.; Kluger-Bell, B.; Seagroves, S.

    2010-12-01

    The Professional Development Program (PDP) supports participants as they design inquiry activities that help learners improve their research process skills. These skills include the cognitive or reasoning skills that scientists and engineers use while doing research; for example, making a testable hypothesis, coordinating results from multiple experiments, or identifying and evaluating tradeoffs. Past work in the PDP indicated that additional support was needed to help participants design instructional activities that would teach these important skills. A new workshop was therefore developed for the 2009 PDP cycle, entitled "Improving Learners' Process Skills." In this workshop, participants worked in small groups to define specific science and engineering skills found in four past PDP activity designs. Participants distinguished between "simple tasks" and "authentic inquiry" activities that learners could perform as demonstration of the skill. Through this new workshop, participants were able to explicitly discuss ways in which individual process skills are unique or inter-related. In addition, by identifying a "simple task," participants were able to pinpoint areas in which their own designs could be improved to better focus on authentic inquiry tasks. In 2010, the workshop was slightly modified to help participants reconnect the research process skills with the activity content. In addition, the idea of using generic and context-specific scaffolds was also introduced. To make the participants feel like they were contributing to the PDP community, four activity designs actively being worked on in the 2010 cycle were used. Based on participant feedback, this "Improving Learners' Process Skills" workshop should be strongly considered for future returning participants.

  14. An active K/Ka-band antenna array for the NASA ACTS mobile terminal

    NASA Technical Reports Server (NTRS)

    Tulintseff, A.; Crist, R.; Densmore, Art; Sukamto, L.

    1993-01-01

    An active K/Ka-band antenna array is currently under development for NASA's ACTS Mobile Terminal (AMT). The AMT task will demonstrate voice, data, and video communications to and from the AMT vehicle in Los Angeles, California, and a base station in Cleveland, Ohio, via the ACTS satellite at 30 and 20 GHz. Satellite tracking for the land-mobile vehicular antenna system involves 'mechanical dithering' of the antenna, where the antenna radiates a fixed beam 46 deg. above the horizon. The antenna is to transmit horizontal polarization and receive vertical polarization at 29.634 plus or minus 0.15 GHz and 19.914 plus or minus 0.15 GHz, respectively. The active array will provide a minimum of 22 dBW EIRP transmit power density and a -8 dB/K deg. receive sensitivity.

  15. Learner Agency

    ERIC Educational Resources Information Center

    Mick, Carola

    2011-01-01

    This article presents first results of an ethnographic research project in a Luxembourgish primary school that accompanied the development of a school project by children from the fifth grade. Analysing the data children themselves collected with Kodak Zi8 cameras in order to document their project activities, it investigates their possibilities…

  16. 50 CFR 80.51 - What activities are eligible for funding under the Dingell-Johnson Sport Fish Restoration Act?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... under the Dingell-Johnson Sport Fish Restoration Act? 80.51 Section 80.51 Wildlife and Fisheries UNITED... SPORT FISH RESTORATION PROGRAM ADMINISTRATIVE REQUIREMENTS, PITTMAN-ROBERTSON WILDLIFE RESTORATION AND DINGELL-JOHNSON SPORT FISH RESTORATION ACTS Eligible Activities § 80.51 What activities are eligible...

  17. 50 CFR 80.51 - What activities are eligible for funding under the Dingell-Johnson Sport Fish Restoration Act?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... under the Dingell-Johnson Sport Fish Restoration Act? 80.51 Section 80.51 Wildlife and Fisheries UNITED... AND SPORT FISH RESTORATION PROGRAM ADMINISTRATIVE REQUIREMENTS, PITTMAN-ROBERTSON WILDLIFE RESTORATION AND DINGELL-JOHNSON SPORT FISH RESTORATION ACTS Eligible Activities § 80.51 What activities...

  18. 50 CFR 80.51 - What activities are eligible for funding under the Dingell-Johnson Sport Fish Restoration Act?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... under the Dingell-Johnson Sport Fish Restoration Act? 80.51 Section 80.51 Wildlife and Fisheries UNITED... AND SPORT FISH RESTORATION PROGRAM ADMINISTRATIVE REQUIREMENTS, PITTMAN-ROBERTSON WILDLIFE RESTORATION AND DINGELL-JOHNSON SPORT FISH RESTORATION ACTS Eligible Activities § 80.51 What activities...

  19. 50 CFR 80.51 - What activities are eligible for funding under the Dingell-Johnson Sport Fish Restoration Act?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... under the Dingell-Johnson Sport Fish Restoration Act? 80.51 Section 80.51 Wildlife and Fisheries UNITED... SPORT FISH RESTORATION PROGRAM ADMINISTRATIVE REQUIREMENTS, PITTMAN-ROBERTSON WILDLIFE RESTORATION AND DINGELL-JOHNSON SPORT FISH RESTORATION ACTS Eligible Activities § 80.51 What activities are eligible...

  20. 50 CFR 80.50 - What activities are eligible for funding under the Pittman-Robertson Wildlife Restoration Act?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... SPORT FISH RESTORATION PROGRAM ADMINISTRATIVE REQUIREMENTS, PITTMAN-ROBERTSON WILDLIFE RESTORATION AND DINGELL-JOHNSON SPORT FISH RESTORATION ACTS Eligible Activities § 80.50 What activities are eligible...

  1. 50 CFR 80.50 - What activities are eligible for funding under the Pittman-Robertson Wildlife Restoration Act?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... SPORT FISH RESTORATION PROGRAM ADMINISTRATIVE REQUIREMENTS, PITTMAN-ROBERTSON WILDLIFE RESTORATION AND DINGELL-JOHNSON SPORT FISH RESTORATION ACTS Eligible Activities § 80.50 What activities are eligible...

  2. ACT Test

    MedlinePlus

    ... this page helpful? Also known as: ACT; Activated Coagulation Time Formal name: Activated Clotting Time Related tests: ... in the blood called platelets and proteins called coagulation factors are activated in a sequence of steps ...

  3. The Learner's Permit.

    ERIC Educational Resources Information Center

    Mayhew, Daniel R.

    2003-01-01

    Considers the role and value of an extended learner's period in a graduated driver-licensing system through a review of the literature. Concludes that further research is needed on the safety benefits and optional features of the learner period. (Contains 1 figure, 3 tables, and 41 references.) (AUTHOR/WFA)

  4. Understanding Oral Learners

    ERIC Educational Resources Information Center

    Moon, W. Jay

    2012-01-01

    A five-year research project of seminary students from various cultural backgrounds revealed that the slight majority of contemporary seminary students studied are oral learners. Oral learners learn best and have their lives most transformed when professors utilize oral teaching and assessment methods. After explaining several preferences of oral…

  5. Adult Learners in Universities.

    ERIC Educational Resources Information Center

    Baker, Janette, Ed.

    1981-01-01

    Theories on adult development and learning and some of the Ontario universities' programs and services for the adult learner are examined, and Athabasca University, Alberta's answer to the British Open University, is described. Peter O'Donnell discusses adult learners' needs and explains how Athabasca University serves this specific type of…

  6. The Lifelong Learner.

    ERIC Educational Resources Information Center

    Gross, Ronald

    Designed to provide a general guide and stimuli for lifelong learning, this book examines all the positive factors of independent study. Lifelong learning is defined as self-directed growth free from the traditional schooling procedures. Chapters discuss the following: the lifelong learner; profiles of such learners in action; how to be…

  7. A Learner Centered Education.

    ERIC Educational Resources Information Center

    Ballard, Florence N.

    This paper proposes a learner-centered educational system, focusing on aspects that are intrinsically associated with the modern educational system, such as the curriculum, school community, parents, learners, and educational support personnel. It examines: primary level preparation (literacy, numeracy, and basic knowledge; examination and…

  8. Grading Exceptional Learners

    ERIC Educational Resources Information Center

    Jung, Lee Ann; Guskey, Thomas R.

    2010-01-01

    Teachers often grapple with the challenge of giving report card grades to students with learning disabilities and English language learners. The authors offer a five-step model that "offers a fair, accurate, and legal way to adapt the grading process for exceptional learners." The model begins with a high-quality reporting system for all students…

  9. Learner-Centered Education.

    ERIC Educational Resources Information Center

    O'Neil, Robert M.

    There is no clear consensus of the term "learner-centered reform." Learner-centered reform has become by implication either the cause or the consequence of inflated grades, lowered admission requirements, affirmative action, elimination of language and other requirements, student evaluation of teaching, abandonment of research, and many other ills…

  10. Learner-Centered Teaching Techniques in Astronomy 101

    NASA Astrophysics Data System (ADS)

    Jones, L. V.; Marschall, L. A.; Prather, E.

    2003-12-01

    We present preliminary results of studies done on learner-centered teaching techniques with students in Astronomy 101. Results for two classes taught at Gettysburg College this fall will be presented. One class used learner-centered activities, the other did not. A diagnostic survey was given to both classes before and after. Specific newly designed activities were tested as well.

  11. A brief review on anti diabetic plants: Global distribution, active ingredients, extraction techniques and acting mechanisms

    PubMed Central

    Chan, Chung-Hung; Ngoh, Gek-Cheng; Yusoff, Rozita

    2012-01-01

    A study has been conducted with the aim to provide researchers with general information on anti diabetic extracts based on relevant research articles collected from 34 reliable medical journals. The study showed that Asian and African continents have 56% and 17% share of the worldwide distribution of therapeutic herbal plants, respectively. In Asia, India and China are the leading countries in herbal plants research, and there has been an increase in medicinal research on plants extract for diabetes treatment since 1995 in these regions. The information collected shows that plant leaves are about 20% more favorable for storing active ingredients, as compared to other parts of herbal plants. A brief review on the extraction techniques for the mentioned parts is also included. Furthermore, the acting mechanisms for the anti diabetic activity were described, and the related active ingredients were identified. The findings reveal that most of the anti diabetic research is focused on the alteration of glucose metabolism to prevent diabetes. PMID:22654401

  12. Activation-induced cytidine deaminase acts on double-strand breaks in vitro.

    PubMed

    Shen, Hong Ming

    2007-02-01

    Activation-induced cytidine deaminase (AID) is likely responsible for DNA cytidine deamination, although it may also act as an RNA deaminase. It functions on single-stranded DNA, the non-template strand in double-stranded DNA during transcription, or both strands in supercoiled DNA. To ask whether AID is able to deaminate cytidine at DNA breaks, plasmids, containing a SnaBI site (TAC downward arrowGTA) that forms blunt ends after digestion with SnaBI, were generated. If AID deaminates cytidine at the upstream blunt end, the ATG start codon in either of two drug resistance genes will be regenerated after ligation and replication in UDG-null E. coli cells. This study shows that AID targets cytidine at the break. The extent of deamination activity beyond the break is correlated with the base composition in the break region. If the break region is A, T-rich, C > T transitions are extensive. However, when the break region is not A, T-rich, mutations are mainly restricted to the break, similar to findings in vivo. The results indicate that AID has activity on double strand breaks (DSBs). Based on previous and current findings, a somatic hypermutation (SHM) model is proposed, in which collision between the transcription apparatus and the replication fork generates DSBs. After AID acts on break ends, the error-prone DNA repair machinery fixes and creates mutations. PMID:16697045

  13. Contextual interactions determine whether the Drosophila homeodomain protein, Vnd, acts as a repressor or activator

    PubMed Central

    Yu, Zhongxin; Syu, Li-Jyun; Mellerick, Dervla M.

    2005-01-01

    At the molecular level, members of the NKx2.2 family of transcription factors establish neural compartment boundaries by repressing the expression of homeobox genes specific for adjacent domains [Muhr et al. (2001) Cell, 104, 861–873; Weiss et al. (1998) Genes Dev., 12, 3591–3602]. The Drosophila homologue, vnd, interacts genetically with the high-mobility group protein, Dichaete, in a manner suggesting co-operative activation [Zhao and Skeath (2002) Development, 129, 1165–1174]. However, evidence for direct interactions and transcriptional activation is lacking. Here, we present molecular evidence for the interaction of Vnd and Dichaete that leads to the activation of target gene expression. Two-hybrid interaction assays indicate that Dichaete binds the Vnd homeodomain, and additional Vnd sequences stabilize this interaction. In addition, Vnd has two activation domains that are typically masked in the intact protein. Whether vnd can activate or repress transcription is context-dependent. Full-length Vnd, when expressed as a Gal4 fusion protein, acts as a repressor containing multiple repression domains. A divergent domain in the N-terminus, not found in vertebrate Vnd-like proteins, causes the strongest repression. The co-repressor, Groucho, enhances Vnd repression, and these two proteins physically interact. The data presented indicate that the activation and repression domains of Vnd are complex, and whether Vnd functions as a transcriptional repressor or activator depends on both intra- and inter-molecular interactions. PMID:15640442

  14. Learner-Content-Interface as an Approach for Self-Reliant and Student-Centered Learning

    ERIC Educational Resources Information Center

    Nicolay, Robin; Schwennigcke, Bastian; Sahl, Sarah; Martens, Alke

    2015-01-01

    Conceptualization and implementation of computer supported teaching and training is currently not tailored to the paradigm of learner centration. Many technical solutions lack transparency and consistency regarding the supported learner activities. An insight into learners activities correlated to learning tasks is needed. In this paper we outline…

  15. 10 CFR 50.13 - Attacks and destructive acts by enemies of the United States; and defense activities.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Attacks and destructive acts by enemies of the United States; and defense activities. 50.13 Section 50.13 Energy NUCLEAR REGULATORY COMMISSION DOMESTIC... the effects of (a) attacks and destructive acts, including sabotage, directed against the facility...

  16. 10 CFR 50.13 - Attacks and destructive acts by enemies of the United States; and defense activities.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Attacks and destructive acts by enemies of the United States; and defense activities. 50.13 Section 50.13 Energy NUCLEAR REGULATORY COMMISSION DOMESTIC... the effects of (a) attacks and destructive acts, including sabotage, directed against the facility...

  17. 10 CFR 50.13 - Attacks and destructive acts by enemies of the United States; and defense activities.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Attacks and destructive acts by enemies of the United States; and defense activities. 50.13 Section 50.13 Energy NUCLEAR REGULATORY COMMISSION DOMESTIC... the effects of (a) attacks and destructive acts, including sabotage, directed against the facility...

  18. 10 CFR 50.13 - Attacks and destructive acts by enemies of the United States; and defense activities.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Attacks and destructive acts by enemies of the United States; and defense activities. 50.13 Section 50.13 Energy NUCLEAR REGULATORY COMMISSION DOMESTIC... the effects of (a) attacks and destructive acts, including sabotage, directed against the facility...

  19. 10 CFR 50.13 - Attacks and destructive acts by enemies of the United States; and defense activities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Attacks and destructive acts by enemies of the United States; and defense activities. 50.13 Section 50.13 Energy NUCLEAR REGULATORY COMMISSION DOMESTIC... the effects of (a) attacks and destructive acts, including sabotage, directed against the facility...

  20. Long-acting contraceptive agents: structure activity relationships in a series of norethisterone and levonorgestrel esters.

    PubMed

    Bialy, G; Blye, R P; Enever, R P; Naqvi, R H; Lindberg, M C

    1983-03-01

    A large number of esters of norethisterone (17 alpha-ethynyl-17 beta-hydroxyestr-4-en-3-one) and levonorgestrel (D-(-)-13 beta-ethyl-17 alpha-ethynyl-17 beta-hydroxygon-4-en-3-one) were synthesized and tested for biological activity. The test employed in these studies was the duration of estrus suppression in cycling mature rats. In the norethisterone series several esters exhibited duration of activity comparable to that of norethisterone enanthate. In the levonorgestrel series the butanoic, cyclobutylcarboxylic and cyclopropylcarboxylic esters were longer acting than medroxyprogesterone acetate (17 alpha-acetoxy-6 alpha-methylpregn-4-ene-3,20-dione) when prepared as aqueous microcrystalline suspensions. PMID:6419411

  1. Integrative application of active controls (IAAC) technology to an advanced subsonic transport project. Initial act configuration design study

    NASA Technical Reports Server (NTRS)

    1980-01-01

    The performance and economic benefits of a constrained application of Active Controls Technology (ACT) are identified, and the approach to airplane design is established for subsequent steps leading to the development of a less constrained final ACT configuration. The active controls configurations are measured against a conventional baseline configuration, a state-of-the-art transport, to determine whether the performance and economic changes resulting from ACT merit proceeding with the project. The technology established by the conventional baseline configuration was held constant except for the addition of ACT. The wing, with the same planform, was moved forward on the initial ACT configuration to move the loading range aft relative to the wing mean aerodynamic chord. Wing trailing-edge surfaces and surface controls also were reconfigured for load alleviation and structural stabilization.

  2. Integrated Application of Active Controls (IAAC) technology to an advanced subsonic transpot project-demonstration act system definition

    NASA Technical Reports Server (NTRS)

    Hanks, G. W.; Shomber, H. A.; Crumb, C. B.; Flora, C. C.; Macdonald, K. A. B.; Smith, R. D.; Sassi, A. P.; Dorwart, R. J.

    1982-01-01

    The 1985 ACT airplane is the Final Active Controls Technology (ACT) Airplane with the addition of three-axis fly by wire. Thus it retains all the efficiency features of the full ACT system plus the weight and cost savings accruing from deletion of the mechanical control system. The control system implements the full IAAC spectrum of active controls except flutter-mode control, judged essentially nonbeneficial, and incorporates new control surfaces called flaperons to make the most of wing-load alleviation. This redundant electronic system is conservatively designed to preserve the extreme reliability required of crucial short-period pitch augmentation, which provides more than half of the fuel savings.

  3. Schoolyard Inquiry for English Language Learners

    ERIC Educational Resources Information Center

    Westervelt, Miriam

    2007-01-01

    This article presents outdoor inquiry activities to help English Language Learner (ELL) students learn life science concepts. As a public high school ELL science teacher, the author of this article use these place-based and scaffolded inquiry activities outside to reinforce concepts she teaches in the classroom all year long. Through inductive…

  4. Practices and Prospects of Learner Autonomy: Teachers' Perceptions

    ERIC Educational Resources Information Center

    Al Asmari, AbdulRahman

    2013-01-01

    Language learning process works through the learners' own reflection on how they learn and it makes learners active in the sense that they learn to analyze their learning strategies. So they start making decisions, e.g., whether to improve them or not, and in which way. Generally, this trait is missing in traditional language teaching process and…

  5. Factors Driving Learner Success in Online Professional Development

    ERIC Educational Resources Information Center

    Vu, Phu; Cao, Vien; Vu, Lan; Cepero, Jude

    2014-01-01

    This study examined factors that contributed to the success of online learners in an online professional development course. Research instruments included an online survey and learners' activity logs in an online professional development course for 512 in-service teachers. The findings showed that there were several factors affecting online…

  6. Building a Dynamic Online Learning Community among Adult Learners.

    ERIC Educational Resources Information Center

    Wang, Minjuan; Sierra, Christina; Folger, Terre

    2003-01-01

    Examines the nature of learning communities constructed among a diverse group of adult learners in an international online graduate-level course. Discusses independent work, team tasks, the variety of computer-mediated communication tools used, and implications for promoting adult learners' active participation in online learning and instructional…

  7. Nurses' attitudes to active voluntary euthanasia: a survey in the ACT.

    PubMed

    Kitchener, B A

    1998-04-01

    National public opinion polls show a large majority of Australians are in favour of active voluntary euthanasia (AVE). However, most members of the public have had only limited direct experience with dying people. For this reason, surveys of the opinions of medical practitioners and nurses on this issue are of great interest. The present study involved a postal survey in late 1996 of 2,000 randomly selected registered nurses from the Australian Capital Territory (ACT). The ACT has had extensive public debate about this issue. The questionnaire included some questions asked in earlier Australian surveys of the general public and health practitioners. Responses were received from 1218 nurses (61%). A majority of nurses who responded supported AVE as 'sometimes right', be it homicide by request (72%) or physician-assisted suicide (71%). A slightly smaller majority believed the law should be changed to allow homicide by request (69%) and physician-assisted suicide (67%). If AVE were legal, 66% of the nurses indicated they were willing to be involved in the procedure. Only 30% were willing to assist patients to give themselves the lethal dose, while 14% were willing to administer the lethal dose to the patient. Comparing these results with previous surveys, it appears that nurses are less in favour of AVE than the public, but more in favour than medical practitioners. PMID:9744194

  8. Assessing the Literacy Needs of Adult Learners of ESL. ERIC Digest.

    ERIC Educational Resources Information Center

    Santopietro, Kathleen; Peyton, Joy Kreeft

    Traditionally, student assessment has focused on measuring learner skills. Assessment of literacy needs, from the learner's perspective, is also an important part of an instructional program. This digest focuses on ways to determine what learners want or believe they need to learn. Many of the activities described can include or lead to assessment…

  9. Comparing Learner Community Behavior in Multiple Presentations of a Massive Open Online Course

    ERIC Educational Resources Information Center

    Gallagher, Silvia Elena; Savage, Timothy

    2015-01-01

    Massive Online Open Courses (MOOCs) can create large scale communities of learners who collaborate, interact and discuss learning materials and activities. MOOCs are often delivered multiple times with similar content to different cohorts of learners. However, research into the differences of learner communication, behavior and expectation between…

  10. Learner Autonomy as a Predictor of Course Success and Final Grades in Community College Online Courses

    ERIC Educational Resources Information Center

    Yen, Cherng-Jyh; Liu, Simon

    2009-01-01

    This study employed a quantitative research design to examine the predictive relationships between: (a) learner autonomy and course success; and (b) learner autonomy and final grades in community college online courses. Learner autonomy was defined as the characteristic of an individual who exhibited intentional behavior in learning activities.…

  11. Exploring South African Grade 11 Learners' Perceptions of Classroom Inquiry: Validation of a Research Instrument

    ERIC Educational Resources Information Center

    Dudu, Washington T.; Vhurumuku, Elaosi

    2012-01-01

    This paper discusses the adoption and validation of a research instrument, on determining learners' levels of perception of classroom inquiry based on data collected from South African Grade 11 learners. The Learners' Perception of Classroom Inquiry (LPCI) instrument consists only of Likert-type items which rank activities according to how often…

  12. The Effect of Reading on Second-Language Learners' Production in Tasks

    ERIC Educational Resources Information Center

    Collentine, Karina

    2016-01-01

    Tasks provide engaging ways to involve learners in meaningful, real-world activities with the foreign language (FL). Yet selecting classroom tasks suitable to learners' linguistic readiness is challenging, and task-based research is exploring the relationship between learners' overall abilities (e.g., reading, grammatical) and the complexity and…

  13. Fly DPP10 acts as a channel ancillary subunit and possesses peptidase activity.

    PubMed

    Shiina, Yohei; Muto, Tomohiro; Zhang, Zhili; Baihaqie, Ahmad; Yoshizawa, Takamasa; Lee, Hye-In J; Park, Eulsoon; Tsukiji, Shinya; Takimoto, Koichi

    2016-01-01

    Mammalian DPP6 (DPPX) and DPP10 (DPPY) belong to a family of dipeptidyl peptidases, but lack enzyme activity. Instead, these proteins form complexes with voltage-gated K(+) channels in Kv4 family to control their gating and other properties. Here, we find that the fly DPP10 ortholog acts as an ancillary subunit of Kv4 channels and digests peptides. Similarly to mammalian DPP10, the fly ortholog tightly binds to rat Kv4.3 protein. The association causes negative shifts in voltage dependence of channel activation and steady state inactivation. It also results in faster inactivation and recovery from inactivation. In addition to its channel regulatory role, fly DPP10 exhibits significant dipeptidyl peptidase activity with Gly-Pro-MCA (glycyl-L-proline 4-methylcoumaryl-7-amide) as a substrate. Heterologously expressed Flag-tagged fly DPP10 and human DPP4 show similar Km values towards this substrate. However, fly DPP10 exhibits approximately a 6-times-lower relative kcat value normalized with anti-Flag immunoreactivity than human DPP4. These results demonstrate that fly DPP10 is a dual functional protein, controlling Kv4 channel gating and removing bioactive peptides. PMID:27198182

  14. Fly DPP10 acts as a channel ancillary subunit and possesses peptidase activity

    PubMed Central

    Shiina, Yohei; Muto, Tomohiro; Zhang, Zhili; Baihaqie, Ahmad; Yoshizawa, Takamasa; Lee, Hye-in J.; Park, Eulsoon; Tsukiji, Shinya; Takimoto, Koichi

    2016-01-01

    Mammalian DPP6 (DPPX) and DPP10 (DPPY) belong to a family of dipeptidyl peptidases, but lack enzyme activity. Instead, these proteins form complexes with voltage-gated K+ channels in Kv4 family to control their gating and other properties. Here, we find that the fly DPP10 ortholog acts as an ancillary subunit of Kv4 channels and digests peptides. Similarly to mammalian DPP10, the fly ortholog tightly binds to rat Kv4.3 protein. The association causes negative shifts in voltage dependence of channel activation and steady state inactivation. It also results in faster inactivation and recovery from inactivation. In addition to its channel regulatory role, fly DPP10 exhibits significant dipeptidyl peptidase activity with Gly-Pro-MCA (glycyl-L-proline 4-methylcoumaryl-7-amide) as a substrate. Heterologously expressed Flag-tagged fly DPP10 and human DPP4 show similar Km values towards this substrate. However, fly DPP10 exhibits approximately a 6-times-lower relative kcat value normalized with anti-Flag immunoreactivity than human DPP4. These results demonstrate that fly DPP10 is a dual functional protein, controlling Kv4 channel gating and removing bioactive peptides. PMID:27198182

  15. You Can Be in a Group and Still Not Cooperate. Collaborative Approaches and Cooperative Learning Activities for Adult Learners.

    ERIC Educational Resources Information Center

    Parma City School District, OH.

    This handbook defines and describes the benefits of both collaborative approaches and cooperative techniques. An introduction uses watercolor marbling as a metaphor for collaborative approaches and cooperative activities. Section I provides research results regarding problems of adult literacy programs, skills employers want, and Bloom's taxonomy.…

  16. Exploring Shifts in Middle School Learners' Modeling Activity While Generating Drawings, Animations, and Computational Simulations of Molecular Diffusion

    ERIC Educational Resources Information Center

    Wilkerson-Jerde, Michelle H.; Gravel, Brian E.; Macrander, Christopher A.

    2015-01-01

    Modeling and using technology are two practices of particular interest to K-12 science educators. These practices are inextricably linked among professionals, who engage in modeling activity with and across a variety of representational technologies. In this paper, we explore the practices of five sixth-grade girls as they generated models of…

  17. Design Issues Related to the Evaluation of Learner--Computer Interaction in a Web-Based Environment: Activities v. Tasks

    ERIC Educational Resources Information Center

    Hemard, Dominique

    2006-01-01

    If web-based technology is increasingly becoming the central plank of contemporary teaching and learning processes, there is still too little evidence to suggest that it is delivering purposeful learning activities beyond its widely perceived potential as a learning resource providing content and learning objects. This is due in part to the…

  18. Learner Characteristics, Learning Environments and Constructivist Epistemologies.

    ERIC Educational Resources Information Center

    Simpson, Gary

    2001-01-01

    Focuses on a current research project that examines the measurement of learner characteristics (multiple intelligence, learning style, learner ability), learner perceptions of the classroom (constructivist learning environment survey and views about teaching and learning), and learner constructs. (Author/MM)

  19. 78 FR 26650 - Agency Information Collection Activities: African Growth and Opportunity Act Certificate of Origin

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-07

    ... Opportunity Act Certificate of Origin AGENCY: U.S. Customs and Border Protection, Department of Homeland... Certificate of Origin (AGOA). This request for comments is being made pursuant to the Paperwork Reduction Act...: Title: African Growth and Opportunity Act Certificate of Origin. OMB Number: 1651-0082. Form...

  20. 78 FR 42103 - Agency Information Collection Activities: African Growth and Opportunity Act Certificate of Origin

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-15

    ... previously published in the Federal Register (78 FR 26650) on May 7, 2013, allowing for a 60-day comment... Opportunity Act Certificate of Origin AGENCY: U.S. Customs and Border Protection, Department of Homeland... accordance with the Paperwork Reduction Act: African Growth and Opportunity Act Certificate of Origin...

  1. 75 FR 9423 - Agency Information Collection Activities: African Growth and Opportunity Act Certificate of Origin

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-02

    ... Opportunity Act Certificate of Origin AGENCY: U.S. Customs and Border Protection (CBP), Department of Homeland... requirement concerning the African Growth and Opportunity Act Certificate of Origin (AGOA). This request for...: Title: African Growth and Opportunity Act Certificate of Origin. OMB Number: 1651-0082. Form...

  2. 45 CFR 90.3 - What programs or activities does the Age Discrimination Act of 1975 cover?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... cover? (a) The Age Discrimination Act of 1975 applies to any program or activity receiving Federal... employer, employment agency, labor organization, or any labor-management joint apprenticeship training program, except for any program or activity receiving Federal financial assistance for public...

  3. 45 CFR 90.3 - What programs or activities does the Age Discrimination Act of 1975 cover?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... cover? (a) The Age Discrimination Act of 1975 applies to any program or activity receiving Federal... employer, employment agency, labor organization, or any labor-management joint apprenticeship training program, except for any program or activity receiving Federal financial assistance for public...

  4. 45 CFR 90.3 - What programs or activities does the Age Discrimination Act of 1975 cover?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... cover? (a) The Age Discrimination Act of 1975 applies to any program or activity receiving Federal... employer, employment agency, labor organization, or any labor-management joint apprenticeship training program, except for any program or activity receiving Federal financial assistance for public...

  5. 45 CFR 90.3 - What programs or activities does the Age Discrimination Act of 1975 cover?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... cover? (a) The Age Discrimination Act of 1975 applies to any program or activity receiving Federal... employer, employment agency, labor organization, or any labor-management joint apprenticeship training program, except for any program or activity receiving Federal financial assistance for public...

  6. 45 CFR 90.3 - What programs or activities does the Age Discrimination Act of 1975 cover?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false What programs or activities does the Age Discrimination Act of 1975 cover? 90.3 Section 90.3 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION NONDISCRIMINATION ON THE BASIS OF AGE IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE General § 90.3...

  7. PKR is activated by cellular dsRNAs during mitosis and acts as a mitotic regulator

    PubMed Central

    Kim, Yoosik; Lee, Jung Hyun; Park, Jong-Eun; Cho, Jun; Yi, Hyerim; Kim, V. Narry

    2014-01-01

    dsRNA-dependent protein kinase R (PKR) is a ubiquitously expressed enzyme well known for its roles in immune response. Upon binding to viral dsRNA, PKR undergoes autophosphorylation, and the phosphorylated PKR (pPKR) regulates translation and multiple signaling pathways in infected cells. Here, we found that PKR is activated in uninfected cells, specifically during mitosis, by binding to dsRNAs formed by inverted Alu repeats (IRAlus). While PKR and IRAlu-containing RNAs are segregated in the cytosol and nucleus of interphase cells, respectively, they interact during mitosis when nuclear structure is disrupted. Once phosphorylated, PKR suppresses global translation by phosphorylating the α subunit of eukaryotic initiation factor 2 (eIF2α). In addition, pPKR acts as an upstream kinase for c-Jun N-terminal kinase and regulates the levels of multiple mitotic factors such as CYCLINS A and B and POLO-LIKE KINASE 1 and phosphorylation of HISTONE H3. Disruption of PKR activation via RNAi or expression of a transdominant-negative mutant leads to misregulation of the mitotic factors, delay in mitotic progression, and defects in cytokinesis. Our study unveils a novel function of PKR and endogenous dsRNAs as signaling molecules during the mitosis of uninfected cells. PMID:24939934

  8. Assessment of MSFCs Process for the Development and Activation of Space Act Agreements

    NASA Technical Reports Server (NTRS)

    Daugherty, Rachel A.

    2014-01-01

    A Space Act Agreement (SAA) is a contractual vehicle that NASA utilizes to form partnerships with non-NASA entities to stimulate cutting-edge innovation within the science and technology communities while concurrently supporting the NASA missions. SAAs are similar to traditional contracts in that they involve the commitment of Agency resources but allow more flexibility and are more cost effective to implement than traditional contracts. Consequently, the use of SAAs to develop partnerships has greatly increased over the past several years. To facilitate this influx of SAAs, Marshall Space Flight Center (MSFC) developed a process during a kaizen event to streamline and improve the quality of SAAs developed at the Center level. This study assessed the current SAA process to determine if improvements could be implemented to increase productivity, decrease time to activation, and improve the quality of deliverables. Using a combination of direct procedural observation, personnel interviews, and statistical analysis, elements of the process in need of remediation were identified and potential solutions developed. The findings focus primarily on the difficulties surrounding tracking and enforcing process adherence and communication issues among stakeholders. Potential solutions include utilizing customer relationship management (CRM) software to facilitate process coordination and co-locating or potentially merging the two separate organizations involved in SAA development and activation at MSFC.

  9. Work activity of persons working as members of advisory committees established under the Federal Advisory Committee Act (FACA). Final rule.

    PubMed

    2006-01-20

    We are revising our disability regulations under titles II and XVI of the Social Security Act to establish a new, special rule that affects individuals who are receiving payments or providing services as members or consultants of a committee, board, commission, council or similar group established under the Federal Advisory Committee Act (FACA). Under this special rule, we will not count any earnings an individual is receiving from serving as a member or consultant of a FACA advisory committee when we determine if the individual is engaging in substantial gainful activity under titles II and XVI of the Social Security Act (the Act). In addition, we will not evaluate any of the services the individual is providing as a member or consultant of the FACA advisory committee when determining if the individual has engaged in substantial gainful activity under titles II and XVI of the Act. Based on our experience with FACA advisory committees and the frequency and level of activity required by these committees, we believe that performance of activity on these committees does not demonstrate the ability to perform substantial gainful activity. We believe this to be consistent with Congress's view, as it has recognized in creating the Ticket to Work advisory committee, for example, that current disability beneficiaries should be considered for membership. This also will encourage individuals with disabilities to serve on FACA advisory committees, thereby providing the benefit of their unique perspective on policies and programs to the Federal Government. PMID:16479696

  10. A Novel Method for Learner Assessment Based on Learner Annotations

    ERIC Educational Resources Information Center

    Noorbehbahani, Fakhroddin; Samani, Elaheh Biglar Beigi; Jazi, Hossein Hadian

    2013-01-01

    Assessment is one of the most essential parts of any instructive learning process which aims to evaluate a learner's knowledge about learning concepts. In this work, a new method for learner assessment based on learner annotations is presented. The proposed method exploits the M-BLEU algorithm to find the most similar reference annotations…

  11. Activated Murine B Lymphocytes and Dendritic Cells Produce a Novel CC Chemokine which Acts Selectively on Activated T Cells

    PubMed Central

    Schaniel, Christoph; Pardali, Evangelia; Sallusto, Federica; Speletas, Mattheos; Ruedl, Christiane; Shimizu, Takeyuki; Seidl, Thomas; Andersson, Jan; Melchers, Fritz; Rolink, Antonius G.; Sideras, Paschalis

    1998-01-01

    Genes were isolated using the suppression subtractive hybridization method by stimulation of pro/pre B cells with anti-CD40 and interleukin (IL)-4 to mature Sμ-Sε–switched cells. One of the strongly upregulated genes encodes a novel murine CC chemokine we have named ABCD-1. The ABCD-1 gene has three exons separated by 1.2- and 2.7-kb introns. It gives rise to a 2.2-kb transcript containing an open reading frame of 276 nucleotides. Two polyadenylation sites are used, giving rise to cDNAs with either 1550 or 1850 bp of 3′ untranslated regions. The open reading frame encodes a 24 amino acid–long leader peptide and a 68 amino acid–long mature protein with a predicted molecular mass of 7.8 kD. ABCD-1 mRNA is found in highest quantities in activated splenic B lymphocytes and dendritic cells. Little chemokine mRNA is present in lung, in unstimulated splenic cells, in thymocytes, and in lymph node cells. No ABCD-1 mRNA is detected in bone marrow, liver, kidney, or brain, in peritoneal exudate cells as well as in the majority of all unstimulated B lineage cells tested. It is also undetectable in Concanavalin A–activated/IL-2–restimulated splenic T cells, and in bone marrow–derived IL-2–induced natural killer cells and IL-3–activated macrophages. Recombinant ABCD-1 revealed a concentration-dependent and specific migration of activated splenic T lymphoblasts in chemotaxis assays. FACS® analyses of migrated cells showed no preferential difference in migration of CD4+ versus CD8+ T cell blasts. Murine as well as human T cells responded to ABCD-1. Freshly isolated cells from bone marrow, thymus, spleen, and lymph node, IL-2–activated NK cells, and LPS-stimulated splenic cells, all did not show any chemotactic response. Thus, ABCD-1 is the first chemokine produced in large amounts by activated B cells and acting selectively on activated T lymphocytes. Therefore, ABCD-1 is expected to play an important role in the collaboration of dendritic cells and B

  12. Highlights of the Carl Perkins Act.

    ERIC Educational Resources Information Center

    Terry, David R.; And Others

    1985-01-01

    Contains "Adult Learner and the Perkins Act" (Terry); "Special Needs Provisions of the Perkins Act" (Cobb, Kingsbury); "Strengthening the Academic Foundations of Vocational Education" (Parks, Henderson); "Planning New Directions for Consumer and Homemaking Education" (Kister, Smith, Hughes); "Sex Equity and the Carl Perkins Act" (Thompson,…

  13. Acting Atoms.

    ERIC Educational Resources Information Center

    Farin, Susan Archie

    1997-01-01

    Describes a fun game in which students act as electrons, protons, and neutrons. This activity is designed to help students develop a concrete understanding of the abstract concept of atomic structure. (DKM)

  14. Morphological Family Size Effects in Young First and Second Language Learners: Evidence of Cross-Language Semantic Activation in Visual Word Recognition

    ERIC Educational Resources Information Center

    de Zeeuw, Marlies; Verhoeven, Ludo; Schreuder, Robert

    2012-01-01

    This study examined to what extent young second language (L2) learners showed morphological family size effects in L2 word recognition and whether the effects were grade-level related. Turkish-Dutch bilingual children (L2) and Dutch (first language, L1) children from second, fourth, and sixth grade performed a Dutch lexical decision task on words…

  15. Instructional Prescriptions for Learner Control.

    ERIC Educational Resources Information Center

    Chung, Jaesam; Reigeluth, Charles M.

    1992-01-01

    Discussion of learner control in instructional management describes six learner control methods: (1) content control; (2) sequence control; (3) pace control; (4) display or strategy control; (5) internal processing control; and (6) advisor strategies. Relevant literature, both theoretical and empirical, is reviewed, and learner control and…

  16. Motivating Literacy Learners in Today's World

    ERIC Educational Resources Information Center

    Fletcher, J., Ed.; Parkhill, F., Ed.; Gillon, G., Ed.

    2010-01-01

    "Motivating Literacy Learners in Today's World" provides insights into a broad spectrum of children's literacy learning. Motivation is the key theme and the authors show how this can be achieved through reading for pleasure; in writing activities at a number of levels; and through oral language development. Chapters include: (1) Motivating…

  17. Goals, the Learner, and the Language Arts.

    ERIC Educational Resources Information Center

    Ediger, Marlow

    Teachers, principals, and supervisors need to determine the kinds of learners being taught in the school/class setting. Are pupils good by nature, bad, or neutral? Concepts held pertaining to each pupil assist in determining objectives, learning activities, and evaluation techniques. The Puritans believed that individuals were born evil or sinful.…

  18. Learner Generated versus Instructor Induced Visual Imagery.

    ERIC Educational Resources Information Center

    Lenze, James S.

    The concepts of imagery, mathemagenic behaviors, and generative imagery are reviewed; and the learner's use of visual imagery is discussed. Several studies have supported the idea that imagery is an active mental process that gives birth to learning. The concept of mathemagenic control or manipulation is of interest to the instructional designer.…

  19. Effective Strategies for Engaging Adult Learners

    ERIC Educational Resources Information Center

    Karge, Belinda Dunnick; Phillips, Kathleen M.; Jessee, Tammy; McCabe, Marjorie

    2011-01-01

    Innovative methods in teaching should be used in every college classroom to enhance student engagement, support any teaching environment and encourage inquiry among learners. Adults learn best by participation in relevant experiences and utilization of practical information. When adult students are active in their learning they are able to develop…

  20. Workplace Learning in Malaysia: The Learner's Perspective

    ERIC Educational Resources Information Center

    Muhamad, Mazanah; Idris, Khairuddin

    2005-01-01

    This paper offers a scenario of workplace learning as practiced in Malaysia. Based on survey research, the article describes learner profiles, learning provision and pattern. The analysis shows that Malaysians participate in formal workplace learning as part of their employment activities. Workplace learning in Malaysia is contextual, promoted by…

  1. Supporting a Learner Community with Software Agents

    ERIC Educational Resources Information Center

    Taurisson, Neil; Tchounikine, Pierre

    2004-01-01

    This paper describes a multi-agent approach that aims at supporting learners involved in a collective activity. We consider pedagogical situations where students have to explicitly define the articulation of their collective work and then achieve the different tasks they have defined. Our objective is to support these students by taking some of…

  2. Instructional Practices That Promote Reading Proficiency for English Language Learners in Grades 3 and 5

    ERIC Educational Resources Information Center

    Smiley-Blanton, Regina

    2010-01-01

    The No Child Left Behind Act (NCLB) requires that all public school students, including English language learners, achieve proficiency in reading, math, and science by 2014 as measured on state assessments. English language learners enrolled in public schools for the first time receive a 1-year deferment from these state assessments in subjects…

  3. Pragmatic Development of Chinese EFL Learners--A Study on FL Suggestions

    ERIC Educational Resources Information Center

    Gu, Tongqing

    2014-01-01

    While the number of studies on the pragmatic development of nonnative English speakers has been increasing, surprisingly little research has been conducted on the development of the ability of foreign language learners to perform the suggestion speech act, with even less taking Chinese EFL learners as the target group. The present study examines…

  4. EGameFlow: A Scale to Measure Learners' Enjoyment of E-Learning Games

    ERIC Educational Resources Information Center

    Fu, Fong-Ling; Su, Rong-Chang; Yu, Sheng-Chin

    2009-01-01

    In an effective e-learning game, the learner's enjoyment acts as a catalyst to encourage his/her learning initiative. Therefore, the availability of a scale that effectively measures the enjoyment offered by e-learning games assist the game designer to understanding the strength and flaw of the game efficiently from the learner's points of view.…

  5. Slow acting protein extract from fruit pulp of Momordica charantia with insulin secretagogue and insulinomimetic activities.

    PubMed

    Yibchok-anun, Sirintorn; Adisakwattana, Sirichai; Yao, Cheng Yu; Sangvanich, Polkit; Roengsumran, Sophon; Hsu, Walter Haw

    2006-06-01

    The protein from Thai bitter gourd (Momordica charantia) fruit pulp was extracted and studied for its hypoglycemic effect. Subcutaneous administration of the protein extract (5, 10 mg/kg) significantly and markedly decreased plasma glucose concentrations in both normal and streptozotocin-induced diabetic rats in a dose-dependent manner. The onset of the protein extract-induced antihyperglycemia/hypoglycemia was observed at 4 and 6 h in diabetic and normal rats, respectively. This protein extract also raised plasma insulin concentrations by 2 fold 4 h following subcutaneous administration. In perfused rat pancreas, the protein extract (10 microg/ml) increased insulin secretion, but not glucagon secretion. The increase in insulin secretion was apparent within 5 min of administration and was persistent during 30 min of administration. Furthermore, the protein extract enhanced glucose uptake into C2C12 myocytes and 3T3-L1 adipocytes. Time course experiments performed in rat adipocytes revealed that M. charantia protein extract significantly increased glucose uptake after 4 and 6 h of incubation. Thus, the M. charantia protein extract, a slow acting chemical, exerted both insulin secretagogue and insulinomimetic activities to lower blood glucose concentrations in vivo. PMID:16755004

  6. Neuropeptide Y acts in the paraventricular nucleus to suppress sympathetic nerve activity and its baroreflex regulation.

    PubMed

    Cassaglia, Priscila A; Shi, Zhigang; Li, Baoxin; Reis, Wagner L; Clute-Reinig, Nicholas M; Stern, Javier E; Brooks, Virginia L

    2014-04-01

    Neuropeptide Y (NPY), a brain neuromodulator that has been strongly implicated in the regulation of energy balance, also acts centrally to inhibit sympathetic nerve activity (SNA); however, the site and mechanism of action are unknown. In chloralose-anaesthetized female rats, nanoinjection of NPY into the paraventricular nucleus of the hypothalamus (PVN) dose-dependently suppressed lumbar SNA (LSNA) and its baroreflex regulation, and these effects were blocked by prior inhibition of NPY Y1 or Y5 receptors. Moreover, PVN injection of Y1 and Y5 receptor antagonists in otherwise untreated rats increased basal and baroreflex control of LSNA, indicating that endogenous NPY tonically inhibits PVN presympathetic neurons. The sympathoexcitation following blockade of PVN NPY inhibition was eliminated by prior PVN nanoinjection of the melanocortin 3/4 receptor inhibitor SHU9119. Moreover, presympathetic neurons, identified immunohistochemically using cholera toxin b neuronal tract tracing from the rostral ventrolateral medulla (RVLM), express NPY Y1 receptor immunoreactivity, and patch-clamp recordings revealed that both NPY and α-melanocyte-stimulating hormone (α-MSH) inhibit and stimulate, respectively, PVN-RVLM neurons. Collectively, these data suggest that PVN NPY inputs converge with α-MSH to influence presympathetic neurons. Together these results identify endogenous NPY as a novel and potent inhibitory neuromodulator within the PVN that may contribute to changes in SNA that occur in states associated with altered energy balance, such as obesity and pregnancy. PMID:24535439

  7. Neuropeptide Y acts in the paraventricular nucleus to suppress sympathetic nerve activity and its baroreflex regulation

    PubMed Central

    Cassaglia, Priscila A; Shi, Zhigang; Li, Baoxin; Reis, Wagner L; Clute-Reinig, Nicholas M; Stern, Javier E; Brooks, Virginia L

    2014-01-01

    Neuropeptide Y (NPY), a brain neuromodulator that has been strongly implicated in the regulation of energy balance, also acts centrally to inhibit sympathetic nerve activity (SNA); however, the site and mechanism of action are unknown. In chloralose-anaesthetized female rats, nanoinjection of NPY into the paraventricular nucleus of the hypothalamus (PVN) dose-dependently suppressed lumbar SNA (LSNA) and its baroreflex regulation, and these effects were blocked by prior inhibition of NPY Y1 or Y5 receptors. Moreover, PVN injection of Y1 and Y5 receptor antagonists in otherwise untreated rats increased basal and baroreflex control of LSNA, indicating that endogenous NPY tonically inhibits PVN presympathetic neurons. The sympathoexcitation following blockade of PVN NPY inhibition was eliminated by prior PVN nanoinjection of the melanocortin 3/4 receptor inhibitor SHU9119. Moreover, presympathetic neurons, identified immunohistochemically using cholera toxin b neuronal tract tracing from the rostral ventrolateral medulla (RVLM), express NPY Y1 receptor immunoreactivity, and patch-clamp recordings revealed that both NPY and α–melanocyte-stimulating hormone (α-MSH) inhibit and stimulate, respectively, PVN–RVLM neurons. Collectively, these data suggest that PVN NPY inputs converge with α-MSH to influence presympathetic neurons. Together these results identify endogenous NPY as a novel and potent inhibitory neuromodulator within the PVN that may contribute to changes in SNA that occur in states associated with altered energy balance, such as obesity and pregnancy. PMID:24535439

  8. Doing Your Part To Help Your Child Become SMART (Successful, Motivated, Autonomous, Responsible, Thoughtful): Six Workshops on Parenting SMART Learners.

    ERIC Educational Resources Information Center

    Sattes, Beth; Walsh, Jackie; Hickman, Mickey

    A SMART Learner is a lifelong learner who can adapt to rapid change and who possesses characteristics associated with success in and out of school. These workshop materials to help parents help their children become SMART learners provide: information from current research and best practice; learning activities that will actively engage parents in…

  9. 78 FR 56153 - National Environmental Policy Act: Categorical Exclusions for Soil and Water Restoration Activities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-12

    ...The U. S. Department of Agriculture, Forest Service, gives notice of revised procedures for implementing the National Environmental Policy Act and Council on Environmental Quality regulations. These final implementing procedures are being issued in regulations concerning National Environmental Policy Act Compliance, which describes categorical exclusions. Categorical exclusions (CE) are......

  10. 78 FR 23280 - Agency Information Collection Activities: United States-Caribbean Basin Trade Partnership Act...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-18

    ...-Caribbean Basin Trade Partnership Act (CBTPA) AGENCY: U.S. Customs and Border Protection (CBP), Department... collection requirement concerning the United States-Caribbean Basin Trade Partnership Act (CBTPA). This... Rulings, Office of International Trade, 90 K Street NE., 10th Floor, Washington, DC 20229- 1177, at...

  11. Fragile Identities: Exploring Learner Identity, Learner Autonomy and Motivation through Young Learners' Voices

    ERIC Educational Resources Information Center

    Lamb, Terry Eric

    2011-01-01

    Recent research in the fields of motivation and learner autonomy in language learning has begun to explore their relationships to the construct of identity. This article builds on this through the voices of a group of six learners of French or German in a secondary school in England, over a two-year period. These young learners initially reveal a…

  12. The Older Language Learner.

    ERIC Educational Resources Information Center

    Schleppegrell, Mary

    Research on adult learning shows that there is no decline in ability to learn as people get older, that except for minor considerations such as hearing and vision loss, the age of the adult learner is not a major factor in language acquisition, and that the context in which adults learn is the major influence on their ability to acquire a new…

  13. Supporting Learners in Training.

    ERIC Educational Resources Information Center

    Montague, Ann; Hopkins, Linda

    A project was conducted in Australia to investigate the most effective ways whereby learners receive informal and formal support to assist them to successfully complete vocational education and training (VET), either in school or in business job-training programs. Data were collected through a literature review, a case study of 11 organizations,…

  14. Serving the Online Learner

    ERIC Educational Resources Information Center

    Boettcher, Judith V.

    2007-01-01

    Systems and services for recruiting, advising, and support of online students have seldom been at the top of the list when planning online and distance learning programs. That is now changing: Forces pushing advising and support services into the foreground include recognition of the student learner as "customer" and the increasing expectations…

  15. School Learners & Libraries.

    ERIC Educational Resources Information Center

    Karlsson, Jenni, Ed.

    This document presents papers from a conference held in November 1995 in Durban, KwaZulu-Natal, convened by the Education Policy Unit (EPU) of the University of Natal as part of research concerning the provision of library-based resources for school learners. Following an introduction are two chapters: "Identifying the Inherited Problems in the…

  16. Helping Young Hispanic Learners

    ERIC Educational Resources Information Center

    Garcia, Eugene E.; Jensen, Bryant

    2007-01-01

    Hispanics are the largest and youngest ethnic group in the United States. Moreover, young Hispanic children make up approximately 80 percent of the U.S. English language learner population. They are a heterogeneous group, born both inside and outside the United States and having origins in Mexico, Cuba, Central America, South America, and the…

  17. Empowering Leaders & Learners

    ERIC Educational Resources Information Center

    Umphrey, Jan

    2013-01-01

    Trevor Greene, the 2013 MetLife/NASSP National High School Principal of the Year, empowers staff members and students to be the best teachers and learners they can be and provides the community resources to support them. In this article, Greene, principal of Toppenish High School in Washington, shares his biggest motivator as a school leader and…

  18. Novice Learners in Cyberspace

    ERIC Educational Resources Information Center

    Youn, Soonkyoung

    2004-01-01

    Since the Internet was introduced in the field of Educational Technology, it has predominantly been seen as an instructional tool. A number of educational technologists point out that the Internet can be a powerful instructional tool that encourages learners to be involved in problem-solving by using a great deal of information and to enlarge and…

  19. Learner Autonomy Revisited

    ERIC Educational Resources Information Center

    Illes, Eva

    2012-01-01

    This article explores whether the perception of learner autonomy that is promoted in language pedagogy is suitable for preparing students to perform successfully in the changed circumstances of the use of English. Recent developments, which include the growing role of English as a lingua franca and computer-mediated communication (CMC), give rise…

  20. Libraries and Adult Learners.

    ERIC Educational Resources Information Center

    Josey, E. J., Ed.

    1982-01-01

    Of the 13 essays presented in this special issue on libraries and adult education, 8 focus on programs and services from the public library for adult learners. These essays provide information on: (1) an Education Information Centers Program (EIC) designed to complement employment skills training provided under the Comprehensive Employment and…

  1. Connecting with Latino Learners

    ERIC Educational Resources Information Center

    Rubinstein-Avila, Eliane

    2006-01-01

    The English-only initiatives sweeping the United States are mainstreaming English language learners into content-area classes designed for native or fluent English speakers, with little, if any, English as a second language (ESL) support. This spells trouble for the ever-growing population of Latinos because ESL teachers are not likely to have the…

  2. Gender and Learner Characteristics

    ERIC Educational Resources Information Center

    Hindal, Huda; Reid, Norman; Whitehead, Rex

    2013-01-01

    It is well established that girls and boys perform differently in traditional examinations in most countries. This study looks at a sample of 754 school students in Kuwait (aged about 13) and explores how boys and girls differ in the performance in a range of tests related to learner characteristics. The fundamental question is how boys and girls…

  3. of Iranian EFL Learners

    ERIC Educational Resources Information Center

    Rashidi, Nasser; Mortazavi, Fariba

    2012-01-01

    This research investigated the relationship between vocabulary learning strategies and vocabulary size of Iranian university EFL students. Participants in the present study were a total of 67 EFL learners, studying at Shiraz Azad University as senior English Translation students. The instruments utilized for data collection were three tests: A…

  4. Teachers as Learners

    ERIC Educational Resources Information Center

    Feiman-Nemser, Sharon

    2012-01-01

    In "Teachers as Learners", a collection of landmark essays, noted teacher educator and scholar Sharon Feiman-Nemser shines a light on teacher learning. Arguing that serious and sustained teacher learning is a necessary condition for ambitious student learning, she examines closely how teachers acquire, generate, and use knowledge about teaching…

  5. California's English Learner Students

    ERIC Educational Resources Information Center

    Hill, Laura E.

    2012-01-01

    English Learner (EL) students in California's schools are numerous and diverse, and they lag behind their native-English-speaking peers. Closing the achievement gap for EL students has been a long-standing goal for California educators, and there are some signs of success. Now that EL funding and curriculum issues are receiving a fresh level of…

  6. The Transliterate Learner

    ERIC Educational Resources Information Center

    Bush, Gail

    2012-01-01

    Thomas et al. have defined transliteracy as "the ability to read, write and interact across a range of platforms, tools and media from signing and orality through handwriting, print, TV, radio and film, to digital social networks" (Transliteracy Research Group). The learner who is transliterate builds knowledge, communicates, and interacts across…

  7. 12 CFR 225.145 - Limitations established by the Competitive Equality Banking Act of 1987 on the activities and...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 3 2011-01-01 2011-01-01 false Limitations established by the Competitive Equality Banking Act of 1987 on the activities and growth of nonbank banks. 225.145 Section 225.145 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM BANK HOLDING COMPANIES AND CHANGE IN BANK CONTROL...

  8. 18 CFR 1309.4 - What programs or activities are covered by the Act and this part?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 2 2013-04-01 2012-04-01 true What programs or activities are covered by the Act and this part? 1309.4 Section 1309.4 Conservation of Power and Water... purpose legislative body which: (i) Provides any benefits or assistance to persons based on age; or...

  9. 18 CFR 1309.4 - What programs or activities are covered by the Act and this part?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false What programs or activities are covered by the Act and this part? 1309.4 Section 1309.4 Conservation of Power and Water... purpose legislative body which: (i) Provides any benefits or assistance to persons based on age; or...

  10. 18 CFR 1309.4 - What programs or activities are covered by the Act and this part?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 2 2011-04-01 2011-04-01 false What programs or activities are covered by the Act and this part? 1309.4 Section 1309.4 Conservation of Power and Water... purpose legislative body which: (i) Provides any benefits or assistance to persons based on age; or...

  11. 18 CFR 1309.4 - What programs or activities are covered by the Act and this part?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 2 2014-04-01 2014-04-01 false What programs or activities are covered by the Act and this part? 1309.4 Section 1309.4 Conservation of Power and Water... purpose legislative body which: (i) Provides any benefits or assistance to persons based on age; or...

  12. 18 CFR 1309.4 - What programs or activities are covered by the Act and this part?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 2 2012-04-01 2012-04-01 false What programs or activities are covered by the Act and this part? 1309.4 Section 1309.4 Conservation of Power and Water... purpose legislative body which: (i) Provides any benefits or assistance to persons based on age; or...

  13. Serial follow-up of presurgical treatment using pasireotide long-acting release with or without octreotide long-acting release for naïve active acromegaly.

    PubMed

    Chang, Jan-Shun; Tseng, Ham-Min; Chang, Tien-Chun

    2016-06-01

    The aim of the present study was to evaluate the serial changes of GH and IGF-1 in seven patients with naïve, active acromegaly following presurgical treatment of the somatostatin analog pasireotide long-acting release (LAR) and octreotide LAR. The patients were treated with pasireotide LAR with or without octreotide LAR for two years and underwent transsphenoidal adenomectomy. After treatment with the somatostatin analogs, the surgical cure rate was similar to that in patients who underwent transsphenoidal surgery alone. Diabetes insipidus was not identified in any patients after the operation. Pasireotide LAR was effective on GH as well as IGF-1 suppression and tumor size decreasing when used as the primary therapy. Future large-population studies to investigate the surgical curative rate after presurgical treatment with somatostatin analogs in patients with acromegaly and macroadenomas close to the cavernous sinus are warranted. However, that hyperglycemia developed following pre-surgical treatment with pasireotide should take into consideration. PMID:27117887

  14. Integrated Application of Active Controls (IAAC) technology to an advanced subsonic transport project: Final ACT configuration evaluation

    NASA Technical Reports Server (NTRS)

    1982-01-01

    The Final ACT Configuration Evaluation Task of the Integrated Application of Active Controls (IAAC) technology project within the energy efficient transport program is summarized. The Final ACT Configuration, through application of Active Controls Technology (ACT) in combination with increased wing span, exhibits significant performance improvements over the conventional baseline configuration. At the design range for these configurations, 3590 km, the block fuel used is 10% less for the Final ACT Configuration, with significant reductions in fuel usage at all operational ranges. Results of this improved fuel usage and additional system and airframe costs and the complexity required to achieve it were analyzed to determine its economic effects. For a 926 km mission, the incremental return on investment is nearly 25% at 1980 fuel prices. For longer range missions or increased fuel prices, the return is greater. The technical risks encountered in the Final ACT Configuration design and the research and development effort required to reduce these risks to levels acceptable for commercial airplane design are identified.

  15. 78 FR 38068 - Agency Information Collection Activities: United States-Caribbean Basin Trade Partnership Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-25

    ... previously published in the Federal Register (78 FR 23280) on April 18, 2013, allowing for a 60-day comment... the U.S. with the enactment of the Trade and Development Act of 2000 (PL. 106-200). The objective...

  16. Techniques: Paying Attention to the Place. Part 1--Activities for Instructors and Adult Learners [and] Part 2--Activities for Planning Places for Adult Learning.

    ERIC Educational Resources Information Center

    Fulton, Rodney D.

    1992-01-01

    This two-part article discusses the role of the physical environment in adult learning. In the first part, two activities--environment introduction and visualization--are discussed as ways to develop an awareness for improving the learning environment. In the second part, two planning activities--mapping and geometric coding--are discussed as ways…

  17. New Teacher Standards and Learner Diversity: Ideas for Authentic Assessment.

    ERIC Educational Resources Information Center

    Moore, John; Benton, Janet

    Changing views about learning and schooling affect teacher preparation programs. The paper examines how Kentucky's standards for new teachers relate to addressing learner diversity, explaining how the Kentucky Education Reform Act is a model for affecting statewide change, particularly regarding methods of assessment and examination of learner…

  18. Measuring Parental Support for Children’s Physical Activity in White and African American Parents: The Activity Support Scale for Multiple Groups (ACTS-MG)

    PubMed Central

    Davison, Kirsten K.; Li, Kaigang; Baskin, Monica L.; Cox, Tiffany; Affuso, Olivia

    2010-01-01

    Objectives The Activity Support Scale (ACTS) was expanded for use with African American families. Its factorial invariance and internal reliability were examined for non-Hispanic white and African American parents. Methods The ACTS was modified to improve its applicability to African American families based on information from five focus groups with 27 African American parents of elementary school-aged children. Between 2006 and 2008, the revised scale was administered to 119 African American and 117 non-Hispanic white parents in northeastern NY and Alabama. Its factorial invariance across race/ethnicity and internal consistency were examined. Results Factor analysis of the revised scale, the Activity Support Scale for Multiple Groups (ACTS-MG), identified four parenting factors in white and African American parents including logistic support, modeling, use of community resources to promote physical activity (PA), and restriction of sedentary behaviors. Results supported the scale’s internal reliability and factorial invariance across race/ethnicity. Conclusion The ACTS-MG is appropriate for use with non-Hispanic white and African American families and will enable the extension of current research with white families to the examination of strategies supporting PA in African American families. Additional psychometric work with the ACTS-MG is encouraged. PMID:21111755

  19. Comparative effects of long-acting and short-acting loop diuretics on cardiac sympathetic nerve activity in patients with chronic heart failure

    PubMed Central

    Matsuo, Yae; Kasama, Shu; Toyama, Takuji; Funada, Ryuichi; Takama, Noriaki; Koitabashi, Norimichi; Ichikawa, Shuichi; Suzuki, Yasuyuki; Matsumoto, Naoya; Sato, Yuichi; Kurabayashi, Masahiko

    2016-01-01

    Objective Short-acting loop diuretics are known to enhance cardiac sympathetic nerve activity (CSNA) in patients with chronic heart failure (CHF). The effects of two loop diuretics—long-acting azosemide and short-acting furosemide—on CSNA were evaluated using 123I-metaiodobenzylguanidine (MIBG) scintigraphy in patients with CHF. Methods The present study was a subanalysis of our previously published study, which had reported that serial 123I-MIBG studies were the most useful prognostic indicator in patients with CHF. Patients with CHF (n=208, left ventricular ejection fraction <45%) but no history of cardiac events for at least 5 months prior to the study were identified according to their histories of acute decompensated heart failure requiring hospitalisation. Patients underwent 123I-MIBG scintigraphy immediately before hospital discharge and at a 6-month follow-up. The delayed % denervation, delayed heart/mediastinum count (H/M) ratio and washout rate (WR) were determined using 123I-MIBG scintigraphy. A total of 108 patients were selected, and propensity score matching was used to compare patients treated with either oral azosemide (n=54) or furosemide (n=54). Results After treatment, 123I-MIBG scintigraphic parameters improved in both groups. However, the degree of change in % denervation was −13.8±10.5 in the azosemide group and −5.7±12.7 in the furosemide group (p<0.01), the change in H/M ratio was 0.20±0.16 in the azosemide group and 0.06±0.19 in the furosemide group (p<0.01), and the change in WR was −11.3±9.2% in the azosemide group and −3.0±12.7% in the furosemide group (p<0.01). Moreover, multivariate analysis showed an independent and significant positive relationship between furosemide and δ-WR from hospital discharge to 6 months after treatment in patients with CHF (p=0.001). Conclusions These findings indicate that azosemide suppresses CSNA compared with furosemide in patients with CHF. Trial registration number UMIN000000626

  20. Integrated Application of Active Controls (IAAC) technology to an advanced subsonic transport project: Test act system validation

    NASA Technical Reports Server (NTRS)

    1985-01-01

    The primary objective of the Test Active Control Technology (ACT) System laboratory tests was to verify and validate the system concept, hardware, and software. The initial lab tests were open loop hardware tests of the Test ACT System as designed and built. During the course of the testing, minor problems were uncovered and corrected. Major software tests were run. The initial software testing was also open loop. These tests examined pitch control laws, wing load alleviation, signal selection/fault detection (SSFD), and output management. The Test ACT System was modified to interface with the direct drive valve (DDV) modules. The initial testing identified problem areas with DDV nonlinearities, valve friction induced limit cycling, DDV control loop instability, and channel command mismatch. The other DDV issue investigated was the ability to detect and isolate failures. Some simple schemes for failure detection were tested but were not completely satisfactory. The Test ACT System architecture continues to appear promising for ACT/FBW applications in systems that must be immune to worst case generic digital faults, and be able to tolerate two sequential nongeneric faults with no reduction in performance. The challenge in such an implementation would be to keep the analog element sufficiently simple to achieve the necessary reliability.

  1. Ex vivo activity of the ACT new components pyronaridine and piperaquine in comparison with conventional ACT drugs against isolates of Plasmodium falciparum

    PubMed Central

    2012-01-01

    Background The aim of the present work was to assess i) ex vivo activity of pyronaridine (PND) and piperaquine (PPQ), as new components of artemisinin-based combination therapy (ACT), to define susceptibility baseline, ii) their activities compared to other partner drugs, namely monodesethylamodiaquine (MDAQ), lumefantrine (LMF), mefloquine (MQ), artesunate (AS) and dihydroartemisinin (DHA) against 181 Plasmodium falciparum isolates from African countries, India and Thailand, and iii) in vitro cross-resistance with other quinoline drugs, chloroquine (CQ) or quinine (QN). Methods The susceptibility of the 181 P. falciparum isolates to the nine anti-malarial drugs was assessed using the standard 42-hours 3H-hypoxanthine uptake inhibition method. Results The IC50 values for PND ranged from 0.55 to 80.0 nM (geometric mean = 19.9 nM) and from 11.8 to 217.3 nM for PPQ (geometric mean = 66.8 nM). A significant positive correlation was shown between responses to PPQ and PND responses (rho = 0.46) and between PPQ and MDAQ (rho = 0.30). No significant correlation was shown between PPQ IC50 and responses to other anti-malarial drugs. A significant positive correlation was shown between responses to PND and MDAQ (rho = 0.37), PND and LMF (rho = 0.28), PND and QN (rho = 0.24), PND and AS (rho = 0.19), PND and DHA (rho = 0.18) and PND and CQ (rho = 0.16). All these coefficients of correlation are too low to suggest cross-resistance between PPQ or PND and the other drugs. Conclusions In this study, the excellent anti-malarial activity of PPQ and PND was confirmed. The absence of cross-resistance with quinolines and artemisinin derivatives is consistent with the efficacy of the combinations of PPQ and DHA or PND and AS in areas where parasites are resistant to conventional anti-malarial drugs. PMID:22333675

  2. 76 FR 22095 - Clean Air Act: Opportunity To Comment, Activities Required by Federal Facilities Compliance...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-20

    ...The Environmental Protection Agency (EPA) has entered into a federal facilities compliance agreement with the Tennessee Valley Authority (TVA), Docket No. CAA-04-2010-1760 (Compliance Agreement) to resolve alleged violations of the Clean Air Act and its implementing regulations at the eleven facilities that TVA owns and operates in Alabama, Kentucky, and Tennessee. EPA is hereby providing......

  3. 76 FR 57799 - Agency Information Collection Activities; Proposal That Electronic Filing of Bank Secrecy Act...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-16

    ...FinCEN is proposing to require electronic filing of certain Bank Secrecy Act (BSA) reports not later than June 30, 2012. This requirement will significantly enhance the quality of our electronic data, improve our analytic capabilities in supporting law enforcement requirements and result in significant reduction in real costs to the United States Government and ultimately to U.S. taxpayers.......

  4. Flexibility and Coordination among Acts of Visualization and Analysis in a Pattern Generalization Activity

    ERIC Educational Resources Information Center

    Nilsson, Per; Juter, Kristina

    2011-01-01

    This study aims at exploring processes of flexibility and coordination among acts of visualization and analysis in students' attempt to reach a general formula for a three-dimensional pattern generalizing task. The investigation draws on a case-study analysis of two 15-year-old girls working together on a task in which they are asked to calculate…

  5. 75 FR 26974 - Agency Information Collection Activities: African Growth and Opportunity Act Certificate of Origin

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-13

    ... information collection was previously published in the Federal Register (75 FR 9423) on March 2, 2010... Opportunity Act Certificate of Origin AGENCY: U.S. Customs and Border Protection, Department of Homeland... Certificate of Origin (AGOA). This is a proposed extension of an information collection that was...

  6. 29 CFR 779.110 - Employees in retailing whose activities may bring them under the Act.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... retail or service field whose individual activities constitute engagement in interstate or foreign... individual activities ordinarily constitute engagement in commerce or in the production of goods for...

  7. 29 CFR 779.110 - Employees in retailing whose activities may bring them under the Act.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... retail or service field whose individual activities constitute engagement in interstate or foreign... individual activities ordinarily constitute engagement in commerce or in the production of goods for...

  8. 29 CFR 779.110 - Employees in retailing whose activities may bring them under the Act.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... retail or service field whose individual activities constitute engagement in interstate or foreign... individual activities ordinarily constitute engagement in commerce or in the production of goods for...

  9. 29 CFR 779.110 - Employees in retailing whose activities may bring them under the Act.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... retail or service field whose individual activities constitute engagement in interstate or foreign... individual activities ordinarily constitute engagement in commerce or in the production of goods for...

  10. 29 CFR 779.110 - Employees in retailing whose activities may bring them under the Act.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... retail or service field whose individual activities constitute engagement in interstate or foreign... individual activities ordinarily constitute engagement in commerce or in the production of goods for...

  11. The Learning of Complex Speech Act Behaviour.

    ERIC Educational Resources Information Center

    Olshtain, Elite; Cohen, Andrew

    1990-01-01

    Pre- and posttraining measurement of adult English-as-a-Second-Language learners' (N=18) apology speech act behavior found no clear-cut quantitative improvement after training, although there was an obvious qualitative approximation of native-like speech act behavior in terms of types of intensification and downgrading, choice of strategy, and…

  12. Learner Preferences and Achievement Under Differing Amounts of Learner Practice.

    ERIC Educational Resources Information Center

    Schnackenberg, Heidi L.; Sullivan, Howard J.; Leader, Lars F.; Jones, Elizabeth E. K.

    1998-01-01

    Examines the effects of program mode (i.e., a lean program version containing a basic amount of learner practice versus a full mode containing expanded practice) and learner preference (matched or unmatched) for amount of practice on the achievement, time-in-program, and attitudes of university undergraduate students. Students preferred the lean…

  13. Annual Report to the President and the Congress on Federal Activities Related to the Administration of the Rehabilitation Act of 1973, as Amended. Fiscal Year 1981. Executive Summary.

    ERIC Educational Resources Information Center

    Rehabilitation Services Administration (ED), Washington, DC.

    The fiscal year 1981 annual report of the Rehabilitation Services Administration's activities under the Rehabilitation Act of 1973, as amended, is presented; program operations, program development activities, functions of the National Institute of Handicapped Research, and other provisions of the Act, are described. Program operations include:…

  14. YY1 Acts as a Transcriptional Activator of Hoxa5 Gene Expression in Mouse Organogenesis

    PubMed Central

    Bérubé-Simard, Félix-Antoine; Prudhomme, Christelle; Jeannotte, Lucie

    2014-01-01

    The Hox gene family encodes homeodomain-containing transcriptional regulators that confer positional information to axial and paraxial tissues in the developing embryo. The dynamic Hox gene expression pattern requires mechanisms that differentially control Hox transcription in a precise spatio-temporal fashion. This implies an integrated regulation of neighbouring Hox genes achieved through the sharing and the selective use of defined enhancer sequences. The Hoxa5 gene plays a crucial role in lung and gut organogenesis. To position Hoxa5 in the regulatory hierarchy that drives organ morphogenesis, we searched for cis-acting regulatory sequences and associated trans-acting factors required for Hoxa5 expression in the developing lung and gut. Using mouse transgenesis, we identified two DNA regions included in a 1.5-kb XbaI-XbaI fragment located in the Hoxa4-Hoxa5 intergenic domain and known to control Hoxa4 organ expression. The multifunctional YY1 transcription factor binds the two regulatory sequences in vitro and in vivo. Moreover, the mesenchymal deletion of the Yy1 gene function in mice results in a Hoxa5-like lung phenotype with decreased Hoxa5 and Hoxa4 gene expression. Thus, YY1 acts as a positive regulator of Hoxa5 expression in the developing lung and gut. Our data also support a role for YY1 in the coordinated expression of Hox genes for correct organogenesis. PMID:24705708

  15. Grammatical Processing in Language Learners

    ERIC Educational Resources Information Center

    Clahsen, Harald; Felser, Claudia

    2006-01-01

    The ability to process the linguistic input in real time is crucial for successfully acquiring a language, and yet little is known about how language learners comprehend or produce language in real time. Against this background, we have conducted a detailed study of grammatical processing in language learners using experimental psycholinguistic…

  16. Learner Autonomy and New Technologies.

    ERIC Educational Resources Information Center

    Raya, Manuel Jimenez; Fernandez, Jose Maria Perez

    2002-01-01

    Presents paths for theoretical research and practical procedures that may help teachers make new technology pedagogically relevant. Discusses the need to develop learner autonomy to help students process information in meaningful ways and become independent learners by developing effective learning strategies, transfer skills, and a greater sense…

  17. The Generative Adolescent Mathematical Learner

    ERIC Educational Resources Information Center

    Lawler, Brian R.

    2010-01-01

    The purpose of this paper is to consider the personal epistemologies of generative adolescent mathematical learners. A generative disposition defined a learner who operated mathematically in ways that reflect an internalized authority for knowing and a constructive orientation to knowledge. Drawing upon the radical constructivist teaching…

  18. Chinese English Learners' Strategic Competence

    ERIC Educational Resources Information Center

    Wang, Dianjian; Lai, Hongling; Leslie, Michael

    2015-01-01

    The present study aims to investigate Chinese English learners' ability to use communication strategies (CSs). The subjects are put in a relatively real English referential communication setting and the analyses of the research data show that Chinese English learners, when encountering problems in foreign language (FL) communication, are…

  19. Sensitizing ESL Learners to Genre

    ERIC Educational Resources Information Center

    Swami, Jasti Appa

    2008-01-01

    This article evaluates the efficacy of explicit genre-based instruction by sensitizing the ESL learners to the concept of genre. The main questions addressed are: How does sensitizing ESL learners to the rhetorical move structure of a genre, the communicative purposes of these moves, and linguistic features that realize these moves help them to…

  20. Iranian EFL Learners' Compliment Responses

    ERIC Educational Resources Information Center

    Allami, Hamid; Montazeri, Maryam

    2012-01-01

    The present study aimed at examining the knowledge of Iranian EFL learners in responding to compliments in English, with a focus on the variables of gender, age and educational background. The data were collected through a 24-item English Discourse Completion Task (DCT) to which 40 male and female EFL learners were asked to provide short…

  1. High Ability and Learner Characteristics

    ERIC Educational Resources Information Center

    Hindal, Huda; Reid, Norman; Whitehead, Rex

    2013-01-01

    The outstandingly able learner has been conceptualised, in terms of test and examination performance, as the learner showing superior academic performance which is markedly better than that of peers and in ways regarded as of value by wider society. In Kuwait, such superior examination performance leads to a classification regarded as being…

  2. The Adult Learner: Four Aspects.

    ERIC Educational Resources Information Center

    Lucas, John A., Ed.

    1986-01-01

    Topics concerning the adult learner that are relevant to institutional researchers are addressed in four articles: marketing, predicting success for adult students, enrollment projection, and follow-up studies of adult learners. In "Institutional Research in Support of Marketing the Adult Student," Lydia Jurand notes the importance of identifying…

  3. Profiling Mobile English Language Learners

    ERIC Educational Resources Information Center

    Byrne, Jason; Diem, Robert

    2014-01-01

    The purpose of this study was to use an app-embedded survey to profile language learner demographics. A total of 3,759 EFL language learners from primarily eight L1 backgrounds (French, German, Italian, Japanese, Korean, Russian, Spanish and Thai) responded to the survey embedded within a popular English grammar app. This app has over 500,000…

  4. Assistive Software for Disabled Learners

    ERIC Educational Resources Information Center

    Clark, Sharon; Baggaley, Jon

    2004-01-01

    Previous reports in this series (#32 and 36) have discussed online software features of value to disabled learners in distance education. The current report evaluates four specific assistive software products with useful features for visually and hearing impaired learners: "ATutor", "ACollab", "Natural Voice", and "Just Vanilla". The evaluative…

  5. Forgetting ACT UP

    ERIC Educational Resources Information Center

    Juhasz, Alexandra

    2012-01-01

    When ACT UP is remembered as the pinnacle of postmodern activism, other forms and forums of activism that were taking place during that time--practices that were linked, related, just modern, in dialogue or even opposition to ACT UP's "confrontational activism"--are forgotten. In its time, ACT UP was embedded in New York City, and a larger world,…

  6. Integrated application of active controls (IAAC) technology to an advanced subsonic transport project. Initial ACT configuration design study

    NASA Technical Reports Server (NTRS)

    1980-01-01

    The initial ACT configuration design task of the integrated application of active controls (IAAC) technology project within the Energy Efficient Transport Program is summarized. A constrained application of active controls technology (ACT) resulted in significant improvements over a conventional baseline configuration previously established. The configuration uses the same levels of technology, takeoff gross weight, payload, and design requirements/objectives as the baseline, except for flying qualities, flutter, and ACT. The baseline wing is moved forward 1.68 m. The configuration incorporates pitch-augmented stability (which enabled an approximately 10% aft shift in cruise center of gravity and a 45% reduction in horizontal tail size), lateral/directional-augmented stability, an angle of attack limiter, wing load alleviation, and flutter mode control. This resulted in a 930 kg reduction in airplane operating empty weight and a 3.6% improvement in cruise efficiency, yielding a 13% range increase. Adjusted to the 3590 km baseline mission range, this amounts to 6% block fuel reduction and a 15.7% higher incremental return on investment, using 1978 dollars and fuel cost.

  7. Motivation Classification and Grade Prediction for MOOCs Learners

    PubMed Central

    Xu, Bin; Yang, Dan

    2016-01-01

    While MOOCs offer educational data on a new scale, many educators find great potential of the big data including detailed activity records of every learner. A learner's behavior such as if a learner will drop out from the course can be predicted. How to provide an effective, economical, and scalable method to detect cheating on tests such as surrogate exam-taker is a challenging problem. In this paper, we present a grade predicting method that uses student activity features to predict whether a learner may get a certification if he/she takes a test. The method consists of two-step classifications: motivation classification (MC) and grade classification (GC). The MC divides all learners into three groups including certification earning, video watching, and course sampling. The GC then predicts a certification earning learner may or may not obtain a certification. Our experiment shows that the proposed method can fit the classification model at a fine scale and it is possible to find a surrogate exam-taker. PMID:26884747

  8. Mutants of Escherichia coli heat-labile toxin lacking ADP-ribosyltransferase activity act as nontoxic, mucosal adjuvants.

    PubMed

    Douce, G; Turcotte, C; Cropley, I; Roberts, M; Pizza, M; Domenghini, M; Rappuoli, R; Dougan, G

    1995-02-28

    A nontoxic mutant (LTK7) of the Escherichia coli heat-labile enterotoxin (LT) lacking ADP-ribosylating activity but retaining holotoxin formation was constructed. By using site-directed mutagenesis, the arginine at position 7 of the A subunit was replaced with lysine. This molecule, which was nontoxic in several assays, was able to bind to eukaryotic cells and acted as a mucosal adjuvant for co-administered proteins; BALB/c mice immunized intranasally with LTK7 and ovalbumin developed high levels of serum and local antibodies to ovalbumin and toxin. In addition, mice immunized intranasally with fragment C of tetanus toxin and LTK7 were protected against lethal challenge with tetanus toxin. Thus nontoxic mutants of heat-labile toxin can act as effective intranasal mucosal adjuvants. PMID:7878032

  9. Life Skills Resource Guide for Senior Adult Learners.

    ERIC Educational Resources Information Center

    Leon County Schools, Tallahassee, FL.

    This life resources guide for senior adult learners contains activities in the life skills curriculum. The manual is organized by content area and instructional goal. Under each instructional goal, one or more activities is given. A list of resources is at the end of each section. The activities cover the following topics: (1) consumer education;…

  10. 77 FR 35323 - National Environmental Policy Act: Categorical Exclusions for Soil and Water Restoration Activities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-13

    ... for Soil and Water Restoration Activities AGENCY: Forest Service, USDA. ACTION: Notice of proposed... effects of soil and water restoration projects that are intended to restore the flow of waters into... activities that achieve soil and water restoration objectives. The Forest Service's proposed...

  11. Identification of short-acting κ-opioid receptor antagonists with anxiolytic-like activity.

    PubMed

    Peters, Matthew F; Zacco, Anna; Gordon, John; Maciag, Carla M; Litwin, Linda C; Thompson, Carolann; Schroeder, Patricia; Sygowski, Linda A; Piser, Timothy M; Brugel, Todd A

    2011-07-01

    The κ-opioid receptor plays a central role in mediating the response to stressful life events. Inhibiting κ-opioid receptor signaling is proposed as a mechanism for treating stress-related conditions such as depression and anxiety. Preclinical testing consistently confirms that disruption of κ-opioid signaling is efficacious in animal models of mood disorders. However, concerns about the feasibility of developing antagonists into drugs stem from an unusual pharmacodynamic property of prototypic κ-opioid receptor-selective antagonists; they inhibit receptor signaling for weeks to months after a single dose. Several fundamental questions include - is it possible to identify short-acting antagonists; is long-lasting inhibition necessary for efficacy; and is it safe to develop long-acting antagonists in the clinic. Here, we test representative compounds (AZ-ECPC, AZ-MTAB, and LY-DMPF) from three new chemical series of κ-opioid receptor ligands for long-lasting inhibition. Each compound dose-dependently reversed κ-opioid agonist-induced diuresis. However, unlike the prototypic antagonist, nBNI, which fully inhibited evoked diuresis for at least four weeks, the new compounds showed no inhibition after one week. The two compounds with greater potency and selectivity were tested in prenatally-stressed rats on the elevated plus maze, an exploration-based model of anxiety. Spontaneous exploration of open arms in the elevated plus maze was suppressed by prenatal stress and restored with both compounds. These findings indicate that persistent inhibition is not an inherent property of κ-opioid-selective antagonists and that post-stress dosing with transient inhibitors can be effective in a mood disorder model. This further supports κ-opioid receptor as a promising target for developing novel psychiatric medications. PMID:21539838

  12. Model Learner Outcomes for Science Education.

    ERIC Educational Resources Information Center

    Clark, Richard C.; Hessler, Edward

    This document provides curriculum planners with models of learner outcomes that can be incorporated into a science curriculum and science essential learner outcomes. The first chapter includes a list of educational system values and learner values, philosophy of education, the mission for public education, and learner goals that describe the…

  13. Learning Difficulties in English for Rural Learners

    ERIC Educational Resources Information Center

    Singaravelu, G.

    2010-01-01

    The present study illuminates and diagnoses the learning problems of the rural learners in English Grammar at standard VI. Present study may be useful to ameliorate the rural learners for acquiring competencies in English and eliminates the problems of the learners. It paves way to the teachers to diagnose the learning hurdles of the learners and…

  14. EthA, a Common Activator of Thiocarbamide-Containing Drugs Acting on Different Mycobacterial Targets▿

    PubMed Central

    Dover, Lynn G.; Alahari, Anuradha; Gratraud, Paul; Gomes, Jessica M.; Bhowruth, Veemal; Reynolds, Robert C.; Besra, Gurdyal S.; Kremer, Laurent

    2007-01-01

    Many of the current antimycobacterial agents require some form of cellular activation unmasking reactive groups, which in turn will bind to their specific targets. Therefore, understanding the mechanisms of activation of current antimycobacterials not only helps to decipher mechanisms of drug resistance but may also facilitate the development of alternative activation strategies or of analogues that do not require such processes. Herein, through the use of genetically defined strains of Mycobacterium bovis BCG we provide evidence that EthA, previously shown to activate ethionamide, also converts isoxyl (ISO) and thiacetazone (TAC) into reactive species. These results were further supported by the development of an in vitro assay using purified recombinant EthA, which allowed direct assessment of the metabolism of ISO. Interestingly, biochemical analysis of [14C]acetate-labeled cultures suggested that all of these EthA-activated drugs inhibit mycolic acid biosynthesis via different mechanisms through binding to specific targets. This report is also the first description of the molecular mechanism of action of TAC, a thiosemicarbazone antimicrobial agent that is still used in the treatment of tuberculosis as a second-line drug in many developing countries. Altogether, the results suggest that EthA is a common activator of thiocarbamide-containing drugs. The broad specificity of EthA can now be used to improve the activation process of these drugs, which may help overcome the toxicity problems associated with clinical thiocarbamide use. PMID:17220416

  15. Identification of positive-acting domains in GCN2 protein kinase required for translational activation of GCN4 expression.

    PubMed Central

    Wek, R C; Ramirez, M; Jackson, B M; Hinnebusch, A G

    1990-01-01

    GCN4 is a transcriptional activator of amino acid-biosynthetic genes in the yeast Saccharomyces cerevisiae. GCN2, a translational activator of GCN4 expression, contains a domain homologous to the catalytic subunit of eucaryotic protein kinases. Substitution of a highly conserved lysine residue in the kinase domain abolished GCN2 regulatory function in vivo and its ability to autophosphorylate in vitro, indicating that GCN2 acts as a protein kinase in stimulating GCN4 expression. Elevated GCN2 gene dosage led to derepression of GCN4 under nonstarvation conditions; however, we found that GCN2 mRNA and protein levels did not increase in wild-type cells in response to amino acid starvation. Therefore, it appears that GCN2 protein kinase function is stimulated posttranslationally in amino acid-starved cells. Three dominant-constitutive GCN2 point mutations were isolated that led to derepressed GCN4 expression under nonstarvation conditions. Two of the GCN2(Con) mutations mapped in the kinase domain itself. The third mapped just downstream from a carboxyl-terminal segment homologous to histidyl-tRNA synthetase (HisRS), which we suggested might function to detect uncharged tRNA in amino acid-starved cells and activate the adjacent protein kinase moiety. Deletions and substitutions in the HisRS-related sequences and in the carboxyl-terminal segment in which one of the GCN2(Con) mutation mapped abolished GCN2 positive regulatory function in vivo without lowering autophosphorylation activity in vitro. These results suggest that sequences flanking the GCN2 protein kinase moiety are positive-acting domains required to increase recognition of physiological substrates or lower the requirement for uncharged tRNA to activate kinase activity under conditions of amino acid starvation. Images PMID:2188100

  16. Application of the French Space Operation Act and the Development of Space Activities in the Field of Launchers

    NASA Astrophysics Data System (ADS)

    Cahuzac, F.; Biard, A.

    2012-01-01

    The development of space activities has led France to define a new legal framework: French Space Operation Act (FSOA). The aim of this act, is to define the conditions according to which the French government authorizes and checks the spatial operations under its jurisdiction or its international responsibility as State of launch, according to the international treaties of the UN on space, in particular the Treaty (1967) on Principles Governing the Activities of States in the Exploration and Use of Outer Space, the Convention ( 1972 ) on International Liability for Damage Caused by Space Objects, and the Convention (1975) on Registration of Objects Launched into Outer Space. The main European space centre is the Guiana Space Centre (CSG), settled in France. A clarification of the French legal framework was compulsory to allow the arrival of new launchers (Soyuz and Vega). This act defines the competent authority, the procedure of authorization and licenses, the regime for operations led from foreign countries, the control of spatial objects, the enabling of inspectors, the delegation of monitoring to CNES, the procedure for urgent measures necessary for the safety, the registration of spatial objects. In this framework, the operator is fully responsible of the operation that he leads. He is subjected to a regime of authorization and to governmental technical monitoring delegated to CNES. In case of litigation, the operator gets the State guarantee above a certain level of damage to third party. The introduction of FSOA has led to issue a Technical Regulation set forth, in particular for the safety of persons and property, the protection of public health and the environment. This general regulation is completed by a specific regulation applicable to CSG that covers the preparation phase of the launch, and all specificities of the launch range, as regards the beginning of the launch. The Technical Regulation is based on 30 years of Ariane's activities and on the

  17. Cdk1 activity acts as a quantitative platform for coordinating cell cycle progression with periodic transcription

    PubMed Central

    Banyai, Gabor; Baïdi, Feriel; Coudreuse, Damien; Szilagyi, Zsolt

    2016-01-01

    Cell proliferation is regulated by cyclin-dependent kinases (Cdks) and requires the periodic expression of particular gene clusters in different cell cycle phases. However, the interplay between the networks that generate these transcriptional oscillations and the core cell cycle machinery remains largely unexplored. In this work, we use a synthetic regulable Cdk1 module to demonstrate that periodic expression is governed by quantitative changes in Cdk1 activity, with different clusters directly responding to specific activity levels. We further establish that cell cycle events neither participate in nor interfere with the Cdk1-driven transcriptional program, provided that cells are exposed to the appropriate Cdk1 activities. These findings contrast with current models that propose self-sustained and Cdk1-independent transcriptional oscillations. Our work therefore supports a model in which Cdk1 activity serves as a quantitative platform for coordinating cell cycle transitions with the expression of critical genes to bring about proper cell cycle progression. PMID:27045731

  18. Cetuximab-induced MET activation acts as a novel resistance mechanism in colon cancer cells.

    PubMed

    Song, Na; Liu, Shizhou; Zhang, Jingdong; Liu, Jing; Xu, Ling; Liu, Yunpeng; Qu, Xiujuan

    2014-01-01

    Aberrant MET expression and hepatocyte growth factor (HGF) signaling are implicated in promoting resistance to targeted agents; however, the induced MET activation by epidermal growth factor receptor (EGFR) inhibitors mediating resistance to targeted therapy remains elusive. In this study, we identified that cetuximab-induced MET activation contributed to cetuximab resistance in Caco-2 colon cancer cells. MET inhibition or knockdown sensitized Caco-2 cells to cetuximab-mediated growth inhibition. Additionally, SRC activation promoted cetuximab resistance by interacting with MET. Pretreatment with SRC inhibitors abolished cetuximab-mediated MET activation and rendered Caco-2 cells sensitive to cetuximab. Notably, cetuximab induced MET/SRC/EGFR complex formation. MET inhibitor or SRC inhibitor suppressed phosphorylation of MET and SRC in the complex, and MET inhibitor singly led to disruption of complex formation. These results implicate alternative targeting of MET or SRC as rational strategies for reversing cetuximab resistance in colon cancer. PMID:24714091

  19. Potential long-acting anticonvulsants. 1; Synthesis and activity of succinimides containing an alkylating group at the 2 position.

    PubMed

    Kornet, M J; Crider, A M; Magarian, E O

    1977-03-01

    The synthesis of succinimide derivatives in which alkylating groups have been attached to the 2 positions of the ring or to the para position of the 2-phenyl substituent is described. The alkylating groups used were (a) alpha-haloacetyl, (b) alpha-haloacetamido, (c) maleimido, and (d) maleamyl. These compounds were prepared as potential long-acting anticonvulsants. Several of these derivatives exhibited activity against metrazole-induced seizures comparable to phensuximde, The maleimide 16 and the bromoacetamido derivative 23 exhibited a duration of action of at least 3.5 h. PMID:845873

  20. Both Cyclophilin Inhibitors and Direct-Acting Antivirals Prevent PKR Activation in HCV-Infected Cells

    PubMed Central

    Bobardt, Michael; Chatterji, Udayan; Lim, Precious; Gawlik, Katarzyna; Gallay, Philippe

    2014-01-01

    We and others demonstrated that the contact between NS5A and the host factor CypA is critical for HCV replication. CypI, by disrupting NS5A-CypA complexes, block HCV replication both in vitro and in patients. Since NS5A also binds to PKR, a central component of the IFN response, we investigated the possibility of a relationship between CypA, NS5A and PKR in the IFN response to HCV. HCV-infected cells treated with CypI, DAAs or IFN were analyzed for the expression and activation of various components of the innate response. We found that CypI (cyclosporine A, alisporivir, NIM811 and sanglifehrins), drastically prevented the activation/phosphorylation, but not the expression of IFN-induced PKR in HCV-infected cells. CypI had no effect on the expression or phosphorylation of other components of the innate response such as eiF2, NF-kB, IRF3, IRF9, STAT1 and STAT2, suggesting a specific effect on PKR. No significant activation of IFN-induced PKR was observed in the absence of HCV. Importantly, we found that several classes of DAAs such as NS3/4A protease, NS5B polymerase and NS5A inhibitors also prevented PKR activation. Furthermore, we found that PKR activation by the dsRNA mimic poly I:C cannot be prevented by CypI or DAAs. Our findings suggest that CypI do not have a unique effect on PKR activation, but rather the suppression of HCV replication by any anti-HCV inhibitor, abrogates PKR activation induced by IFN. Moreover, they suggest that the accumulation of dsRNA intermediates allows HCV to exploit the activation of PKR to counteract the IFN response. PMID:24799968

  1. Annual Report to the President and to the Congress on Federal Activities Related to the Rehabilitation Act of 1973, as Amended. Fiscal Year 1992.

    ERIC Educational Resources Information Center

    Rehabilitation Services Administration (ED), Washington, DC.

    This report describes activities of the Rehabilitation Services Administration (RSA) and other federal agencies during fiscal year 1992 in complying with the Rehabilitation Act of 1973, as amended. Following an executive summary, the report is organized according to the Act's titles and sections. Individual sections address the following topics:…

  2. Caught in the act: covalent cross-linking captures activator-coactivator interactions in vivo.

    PubMed

    Krishnamurthy, Malathy; Dugan, Amanda; Nwokoye, Adaora; Fung, Yik-Hong; Lancia, Jody K; Majmudar, Chinmay Y; Mapp, Anna K

    2011-12-16

    Currently there are few methods suitable for the discovery and characterization of transient, moderate affinity protein-protein interactions in their native environment, despite their prominent role in a host of cellular functions including protein folding, signal transduction, and transcriptional activation. Here we demonstrate that a genetically encoded photoactivatable amino acid, p-benzoyl-l-phenylalanine, can be used to capture transient and/or low affinity binding partners in an in vivo setting. In this study, we focused on ensnaring the coactivator binding partners of the transcriptional activator VP16 in S. cerevisiae. The interactions between transcriptional activators and coactivators in eukaryotes are moderate in affinity and short-lived, and due in part to these characteristics, identification of the direct binding partners of activators in vivo has met with only limited success. We find through in vivo photo-cross-linking that VP16 contacts the Swi/Snf chromatin-remodeling complex through the ATPase Snf2(BRG1/BRM) and the subunit Snf5 with two distinct regions of the activation domain. An analogous experiment with Gal4 reveals that Snf2 is also a target of this activator. These results suggest that Snf2 may be a valuable target for small molecule probe discovery given the prominent role the Swi/Snf complex family plays in development and in disease. More significantly, the successful implementation of the in vivo cross-linking methodology in this setting demonstrates that it can be applied to the discovery and characterization of a broad range of transient and/or modest affinity protein-protein interactions. PMID:21977905

  3. The Effect of Instruction on Learners' Pragmatic Awareness: A Focus on Refusals

    ERIC Educational Resources Information Center

    Soler, Eva Alcon; Pitarch, Josep Guzman

    2010-01-01

    The benefits of instruction on learners' production and awareness of speech acts is well documented (see Alcon and Martinez-Flor, 2008, for a review of pragmatics in instructional contexts). However, few studies examine the influence that instruction may have on the cognitive processes involved in speech act production (Felix-Brasdefer, 2008). In…

  4. Educating English-Language Learners with Special Needs: Beyond Cultural and Linguistic Considerations

    ERIC Educational Resources Information Center

    Park, Yujeong; Thomas, Rachel

    2012-01-01

    English-language learners (ELLs) with special needs consistently languish in the American school system. The No Child Left Behind Act (NCLB) included ELLs as a minority group and required to hold schools accountable for reducing the achievement gap between ELLs and their white peers, however the act did not provide a specific direction for…

  5. Preparing Principals for Success with English Language Learners: Challenges and Opportunities in Illinois

    ERIC Educational Resources Information Center

    Reeves, Alison; Van Tuyle, Vicki

    2014-01-01

    This paper explores the challenges and opportunities of the English Language Learner (ELL) components of Illinois' new principal preparation legislation [Illinois Public Act 96-0903]. In 2011, Illinois passed Illinois Public Act 96-0903 creating new rules for principal preparation programs requiring institutions or organizations certifying…

  6. An Attempt to Raise Japanese EFL Learners' Pragmatic Awareness Using Online Discourse Completion Tasks

    ERIC Educational Resources Information Center

    Tanaka, Hiroya; Oki, Nanaho

    2015-01-01

    This practical paper discusses the effect of explicit instruction to raise Japanese EFL learners' pragmatic awareness using online discourse completion tasks. The five-part tasks developed by the authors use American TV drama scenes depicting particular speech acts and include explicit instruction in these speech acts. 46 Japanese EFL college…

  7. Older Learners: A Viable Clientele.

    ERIC Educational Resources Information Center

    O'Donnell, Kathleen M.

    1980-01-01

    As enrollments decline and financial pressures increase, many institutions have developed an interest in older learners as an alternative market for continuing education. Demographic and social factors behind this rising concern with adult education are examined. (JSR)

  8. Evoking the Power of Learners

    PubMed Central

    Hotelling, Barbara A.

    2011-01-01

    Our mandate, as Lamaze International childbirth educators, is to assist women in making healthy pregnancy, birth, and parenting choices. Being mindful of health promotion theory and using learning tasks and dialogue education to provide information creates a collaborative Lamaze class where the teacher is the facilitator and the learners are accountable for their learning. This column offers Lamaze educators a deeper understanding of adult learners and our roles in their birth education. PMID:22942625

  9. ELMOD2 is an Arl2 GTPase-activating protein that also acts on Arfs.

    PubMed

    Bowzard, J Bradford; Cheng, Dongmei; Peng, Junmin; Kahn, Richard A

    2007-06-15

    Regulatory GTPases in the Ras superfamily employ a cycle of alternating GTP binding and hydrolysis, controlled by guanine nucleotide exchange factors and GTPase-activating proteins (GAPs), as essential features of their actions in cells. Studies of these GAPs and guanine nucleotide exchange factors have provided important insights into our understanding of GTPase signaling and biology. Within the Ras superfamily, the Arf family is composed of 30 members in mammals, including 22 Arf-like (Arl) proteins. Much less is known about the mechanisms of cell regulation by Arls than by Arfs. We report the purification from bovine testis of an Arl2 GAP and its identity as ELMOD2, a protein with no previously described function. ELMOD2 is one of six human proteins that contain an ELMO domain, and a second member, ELMOD1, was also found to have Arl2 GAP activity. Surprisingly, ELMOD2 also exhibited GAP activity against Arf proteins even though it does not contain the canonical Arf GAP sequence signature. The broader specificity of ELMOD2, as well as the previously described role for ELMO1 and ELMO2 in linking Arf6 and Rac1 signaling, suggests that ELMO family members may play a more general role in integrating signaling pathways controlled by Arls and other GTPases. PMID:17452337

  10. Some Anticancer Agents Act on Human Serum Paraoxonase-1 to Reduce Its Activity.

    PubMed

    Alim, Zuhal; Beydemir, Şükrü

    2016-08-01

    Human serum paraoxonase (hPON1) is an important antioxidant enzyme. It protects low-density lipoproteins against oxidative stress and prevents atherosclerosis development. Anticancer agents have cardiotoxic effects, and this situation can lead to significant complications. Our aim was to evaluate the in vitro effects of some of the anticancer agents such as cetuximab, paclitaxel, etoposide, docetaxel, and ifosfamide on the activity of hPON1 in this study. For this reason, PON1 was purified from human serum with a specific activity of 3654.2 EU/mg and 16.84% yield using simple chromatographic methods. The five chemotherapeutic agents dose dependently decreased in vitro hPON1 activity. IC50 values for cetuximab, paclitaxel, etoposide, docetaxel, and ifosfamide were 0.0111, 0.042, 0.226, 0.665, and 23.3 mm, respectively. Ki constants were 0.0194, 0.0165, 0.131, 0.291, and 8.973 mm, respectively. The inhibition mechanisms of cetuximab, etoposide, docetaxel, and ifosfamide were non-competitive, and for paclitaxel was competitive. Consequently, inhibition of hPON1 by these anticancer agents may explain some of the cardiotoxic actions of these drugs. PMID:26873069

  11. Choosing to Interact: Exploring the Relationship between Learner Personality, Attitudes, and Tutorial Dialogue Participation

    ERIC Educational Resources Information Center

    Ezen-Can, Aysu; Boyer, Kristy Elizabeth

    2015-01-01

    The tremendous effectiveness of intelligent tutoring systems is due in large part to their interactivity. However, when learners are free to choose the extent to which they interact with a tutoring system, not all learners do so actively. This paper examines a study with a natural language tutorial dialogue system for computer science, in which…

  12. The Interplay between Language, Gestures, Dragging and Diagrams in Bilingual Learners' Mathematical Communications

    ERIC Educational Resources Information Center

    Ng, Oi-Lam

    2016-01-01

    This paper discusses the importance of considering bilingual learners' non-linguistic forms of communication for understanding their mathematical thinking. In particular, I provide a detailed analysis of communication involving a pair of high school bilingual learners during an exploratory activity where a touchscreen-based dynamic geometry…

  13. Toward a Unified Modeling of Learner's Growth Process and Flow Theory

    ERIC Educational Resources Information Center

    Challco, Geiser C.; Andrade, Fernando R. H.; Borges, Simone S.; Bittencourt, Ig I.; Isotani, Seiji

    2016-01-01

    Flow is the affective state in which a learner is so engaged and involved in an activity that nothing else seems to matter. In this sense, to help students in the skill development and knowledge acquisition (referred to as learners' growth process) under optimal conditions, the instructional designers should create learning scenarios that favor…

  14. Create Independent Learners: Teacher-Tested Strategies for ALL Ability Levels.

    ERIC Educational Resources Information Center

    Pavelka, Patricia

    Noting that teachers' ultimate goal for their students is that they begin to apply strategies on their own and learn how to be independent, strategic, successful learners, this book presents numerous activities, strategies, and ideas to help students of all learning abilities in grades 1 through 5 become independent learners. The guide was…

  15. "Can We Do That Again?" Engaging Learners and Developing beyond the "Wow" Factor in Science

    ERIC Educational Resources Information Center

    Astall, Chris; Bruce, Warren

    2010-01-01

    Adding Mentos to an open bottle of Diet Coke can produce a fountain of liquid and froth extending several metres high. This activity can engage a wide audience of learners in a relevant and meaningful way, provide a model for creative science teaching, and help to develop learners' attitudes towards school science as a subject. In this paper, the…

  16. Learner-Centered Psychological Principles: A Framework for School Redesign and Reform.

    ERIC Educational Resources Information Center

    American Psychological Association, Washington, D.C.

    Educators, concerned with disturbing trends in school failure, are arguing for more learner-centered models of schooling. Such a reform effort requires set principles that emphasize the active and reflective nature of learning and learners; 14 such principles are reported here. The immediate goal of this report is to provide a framework that can…

  17. Student Choice of Anonymity for Learner Identity in Online Learning Discussion Forums

    ERIC Educational Resources Information Center

    Freeman, Mark; Bamford, Anne

    2004-01-01

    Academics have a range of learning activities and tools they can incorporate to enable students to achieve the objectives of their courses. Strategies such as role-play have been used with learners in face-to-face settings to allow students to experience learning using a range of learner identities. Yet, with the exception of role-plays,…

  18. Effectiveness of a Learner-Directed Model for e-Learning

    ERIC Educational Resources Information Center

    Lee, Stella; Barker, Trevor; Kumar, Vivekanandan Suresh

    2016-01-01

    It is a hard task to strike a balance between extents of control a learner exercises and the amount of guidance, active or passive, afforded by the learning environment to guide, support, and motivate the learner. Adaptive systems strive to find the right balance in a spectrum that spans between self-control and system-guidance. They also concern…

  19. The Development of Adult Learner Autonomy and Self-Directedness in Distance Education.

    ERIC Educational Resources Information Center

    Kasworm, Carol E.; Yao, Bing

    Distance education's use of the instructional systems design model has been challenged by critics who suggest that the learner is passive and learning is superficial. A suggestion is that distance education should be structured so that learners assume a more active role in the development and use of autonomous and self-directed learning…

  20. The Relationship between Reading Proficiency and Reading Strategy Use: A Study of Adult ESL Learners

    ERIC Educational Resources Information Center

    Huang, Jiuhan; Nisbet, Deanna

    2014-01-01

    This article explores the relationship between reading strategy use and reading proficiency among 121 adult ESL learners. Reading strategy use was measured by the SORS, and reading proficiency was determined by the CASAS Reading Test and BEST Literacy Test. Findings of the study reveal that (a) adult ESL learners are active strategies users; (b)…

  1. Learner Agency and the Use of Affordances in Language-Exchange Interactions

    ERIC Educational Resources Information Center

    Ahn, Tae youn

    2016-01-01

    Language exchange refers to a learning partnership between two learners with different native languages who collaborate to help each other improve their proficiency in the other's language. The purpose of this study is to examine the ways in which language-exchange participants activate learner agency to construct opportunities for learning in…

  2. Language-Related Computer Use: Focus on Young L2 English Learners in Sweden

    ERIC Educational Resources Information Center

    Sundqvist, Pia; Sylvén, Liss Kerstin

    2014-01-01

    This paper presents findings from a study investigating young English language learners (YELLs) in Sweden in 4th grade (N = 76, aged 10-11). Data were collected with the help of a questionnaire and a one-week language diary. The main purpose was to examine the learners' L2 English language-related activities outside of school in general, and…

  3. A Critical Analysis of Learner Participation in Virtual Worlds: How Can Virtual Worlds Inform Our Pedagogy?

    ERIC Educational Resources Information Center

    Panichi, Luisa

    2015-01-01

    This paper reports on an exploratory case study of learner participation within the context of online language learning in virtual world platforms. Data for this investigation was collected through a case study of a Business English course within a qualitative Case-Study Research framework. This study examines learner activity in virtual worlds in…

  4. Capitalising on Learner Agency and Group Work in Learning Writing in English as a Foreign Language

    ERIC Educational Resources Information Center

    Lin, Zheng

    2013-01-01

    This study investigates the roles of learner agency and group work in learning writing in English as a foreign language (EFL). Through exploratory and participatory action research, this study examines how learner agency and group work function amidst the activity system of task-based EFL writing, especially how they influence and are influenced…

  5. Building a Tool to Help Teachers Analyse Learners' Interactions in a Networked Learning Environment

    ERIC Educational Resources Information Center

    Petropoulou, O.; Altanis, I.; Retalis, S.; Nicolaou, C. A.; Kannas, C.; Vasiliadou, M.; Pattis, Ireneos

    2010-01-01

    Educators participating in networked learning communities have very little support from integrated tools in evaluating students' learning activities flow and examining learners' online behaviour. There is a need for non-intrusive ways to monitor learners' progress in order better to follow their learning process and appraise the online course…

  6. Chinese English Learners' Strategic Competence.

    PubMed

    Wang, Dianjian; Lai, Hongling; Leslie, Michael

    2015-12-01

    The present study aims to investigate Chinese English learners' ability to use communication strategies (CSs). The subjects are put in a relatively real English referential communication setting and the analyses of the research data show that Chinese English learners, when encountering problems in foreign language (FL) communication, are characterized by the frequent use of substitution, approximation, circumlocution, literal translation, exemplification, word-coinage, repetition, and the infrequent use of cultural-knowledge and paralinguistic CSs. The rare use of paralinguistic strategies is found to be typical of Chinese English learners. The high frequency of literal translation, one first language (L1)-based strategy in our study sample, suggests that FL learners' use of L1-based CSs may depend more upon the developmental stage of their target language than the typology distance between L1 and the target language. The frequency of repetition reveals one fact that the Chinese English learners lack variety and flexibility in their use of CSs. Based on these findings, it was indicated that learners' use of CSs is influenced by a variety of factors, among which the development stage of their interlanguage and their cultural background are identified as two important factors. Some implications are finally suggested for the English foreign language teaching practice in China. PMID:25134668

  7. Early growth response protein 1 acts as an activator of SOX18 promoter

    PubMed Central

    Petrovic, Isidora; Kovacevic-Grujicic, Natasa

    2010-01-01

    Sex-determining region Y box 18 (Sox18/SOX18) gene is an important regulator of vascular development playing a role in endothelial cell specification or differentiation, angiogenesis and atherogenesis. The aim of this study was to perform comprehensive functional characterization of the human SOX18 promoter, including determination of transcription start point (tsp) and identification of control elements involved in the regulation of SOX18 gene expression, with an emphasis on angiogenesis-related transcription factors. Analyses were performed in HeLa cells, representing a tumor cell line, and in EA.hy926 cells used as an endothelial model system. We have determined unique tsp of SOX18 gene, located 172 nucleotides upstream from ATG codon. Further, we have shown that SOX18 promoter region, -726 to -89 bp relative to tsp, contains positive cis-regulatory element(s) that stimulates SOX18 promoter activity, while region -89 to + 166 represents the minimal promoter. Within this region we have recognized the presence of essential element(s), positioned from -89 to +29, which harbors cluster of three putative early growth response 1 (EGR1) binding sites. By in vitro binding assays and functional analyses we have shown that these three putative binding sites are functionally relevant and sufficient for EGR1-induced SOX18 transcription. Mutations of these binding sites significantly impaired activity of the SOX18 promoter, particularly in EA.hy926 cells, indicating the importance of these regulatory elements for SOX18 promoter activity in endothelial setting. By data presented in this study, we have established SOX18 as a novel target gene regulated by EGR1 transcription factor, thus providing the first functional link between two transcription factors previously shown to be involved in the control of angiogenesis. PMID:20054233

  8. Hepatitis C Virus RNA Replication Depends on Specific Cis- and Trans-Acting Activities of Viral Nonstructural Proteins

    PubMed Central

    Kazakov, Teymur; Yang, Feng; Ramanathan, Harish N.; Kohlway, Andrew; Diamond, Michael S.; Lindenbach, Brett D.

    2015-01-01

    Many positive-strand RNA viruses encode genes that can function in trans, whereas other genes are required in cis for genome replication. The mechanisms underlying trans- and cis-preferences are not fully understood. Here, we evaluate this concept for hepatitis C virus (HCV), an important cause of chronic liver disease and member of the Flaviviridae family. HCV encodes five nonstructural (NS) genes that are required for RNA replication. To date, only two of these genes, NS4B and NS5A, have been trans-complemented, leading to suggestions that other replicase genes work only in cis. We describe a new quantitative system to measure the cis- and trans-requirements for HCV NS gene function in RNA replication and identify several lethal mutations in the NS3, NS4A, NS4B, NS5A, and NS5B genes that can be complemented in trans, alone or in combination, by expressing the NS3–5B polyprotein from a synthetic mRNA. Although NS5B RNA binding and polymerase activities can be supplied in trans, NS5B protein expression was required in cis, indicating that NS5B has a cis-acting role in replicase assembly distinct from its known enzymatic activity. Furthermore, the RNA binding and NTPase activities of the NS3 helicase domain were required in cis, suggesting that these activities play an essential role in RNA template selection. A comprehensive complementation group analysis revealed functional linkages between NS3-4A and NS4B and between NS5B and the upstream NS3–5A genes. Finally, NS5B polymerase activity segregated with a daclatasvir-sensitive NS5A activity, which could explain the synergy of this antiviral compound with nucleoside analogs in patients. Together, these studies define several new aspects of HCV replicase structure-function, help to explain the potency of HCV-specific combination therapies, and provide an experimental framework for the study of cis- and trans-acting activities in positive-strand RNA virus replication more generally. PMID:25875808

  9. Phosphorylation acts positively and negatively to regulate MRTF-A subcellular localisation and activity.

    PubMed

    Panayiotou, Richard; Miralles, Francesc; Pawlowski, Rafal; Diring, Jessica; Flynn, Helen R; Skehel, Mark; Treisman, Richard

    2016-01-01

    The myocardin-related transcription factors (MRTF-A and MRTF-B) regulate cytoskeletal genes through their partner transcription factor SRF. The MRTFs bind G-actin, and signal-regulated changes in cellular G-actin concentration control their nuclear accumulation. The MRTFs also undergo Rho- and ERK-dependent phosphorylation, but the function of MRTF phosphorylation, and the elements and signals involved in MRTF-A nuclear export are largely unexplored. We show that Rho-dependent MRTF-A phosphorylation reflects relief from an inhibitory function of nuclear actin. We map multiple sites of serum-induced phosphorylation, most of which are S/T-P motifs and show that S/T-P phosphorylation is required for transcriptional activation. ERK-mediated S98 phosphorylation inhibits assembly of G-actin complexes on the MRTF-A regulatory RPEL domain, promoting nuclear import. In contrast, S33 phosphorylation potentiates the activity of an autonomous Crm1-dependent N-terminal NES, which cooperates with five other NES elements to exclude MRTF-A from the nucleus. Phosphorylation thus plays positive and negative roles in the regulation of MRTF-A. PMID:27304076

  10. Phosphorylation acts positively and negatively to regulate MRTF-A subcellular localisation and activity

    PubMed Central

    Panayiotou, Richard; Miralles, Francesc; Pawlowski, Rafal; Diring, Jessica; Flynn, Helen R; Skehel, Mark; Treisman, Richard

    2016-01-01

    The myocardin-related transcription factors (MRTF-A and MRTF-B) regulate cytoskeletal genes through their partner transcription factor SRF. The MRTFs bind G-actin, and signal-regulated changes in cellular G-actin concentration control their nuclear accumulation. The MRTFs also undergo Rho- and ERK-dependent phosphorylation, but the function of MRTF phosphorylation, and the elements and signals involved in MRTF-A nuclear export are largely unexplored. We show that Rho-dependent MRTF-A phosphorylation reflects relief from an inhibitory function of nuclear actin. We map multiple sites of serum-induced phosphorylation, most of which are S/T-P motifs and show that S/T-P phosphorylation is required for transcriptional activation. ERK-mediated S98 phosphorylation inhibits assembly of G-actin complexes on the MRTF-A regulatory RPEL domain, promoting nuclear import. In contrast, S33 phosphorylation potentiates the activity of an autonomous Crm1-dependent N-terminal NES, which cooperates with five other NES elements to exclude MRTF-A from the nucleus. Phosphorylation thus plays positive and negative roles in the regulation of MRTF-A. DOI: http://dx.doi.org/10.7554/eLife.15460.001 PMID:27304076

  11. Development and Validation of Quantitative Structure-Activity Relationship Models for Compounds Acting on Serotoninergic Receptors

    PubMed Central

    Żydek, Grażyna; Brzezińska, Elżbieta

    2012-01-01

    A quantitative structure-activity relationship (QSAR) study has been made on 20 compounds with serotonin (5-HT) receptor affinity. Thin-layer chromatographic (TLC) data and physicochemical parameters were applied in this study. RP2 TLC 60F254 plates (silanized) impregnated with solutions of propionic acid, ethylbenzene, 4-ethylphenol, and propionamide (used as analogues of the key receptor amino acids) and their mixtures (denoted as S1–S7 biochromatographic models) were used in two developing phases as a model of drug-5-HT receptor interaction. The semiempirical method AM1 (HyperChem v. 7.0 program) and ACD/Labs v. 8.0 program were employed to calculate a set of physicochemical parameters for the investigated compounds. Correlation and multiple linear regression analysis were used to search for the best QSAR equations. The correlations obtained for the compounds studied represent their interactions with the proposed biochromatographic models. The good multivariate relationships (R2 = 0.78–0.84) obtained by means of regression analysis can be used for predicting the quantitative effect of biological activity of different compounds with 5-HT receptor affinity. “Leave-one-out” (LOO) and “leave-N-out” (LNO) cross-validation methods were used to judge the predictive power of final regression equations. PMID:22619602

  12. A Learner-led, Discussion-based Elective on Emerging Infectious Disease

    PubMed Central

    2015-01-01

    Objective. To implement a learner-led, discussion-based course aimed at exposing second-year pharmacy learners to the study of emerging infectious diseases from a global health perspective and to assess the role and importance of pharmacists in the management of disease outbreaks. Design. Learners examined literature pertinent to an emerging infectious disease in a 3-credit, discussion-based course and participated in peer discussion led by a designated learner. Instructional materials included journal articles, audio-visual presentations, documentaries, book chapters, movies, newspaper/magazine articles, and other materials. Learning outcomes were measured based on the ability of learners to perform critical thinking and analysis, communicate with their peers, and participate in class discussions. Assessment. The course was offered to 2 consecutive cohorts consisting of 14 and 16 learners, respectively. Overall, every learner in the first cohort achieved a final grade of A for the course. In the second cohort, the overall grade distribution consisted of grades of A, B, and C for the course. Learner evaluations indicated that the active-learning, discussion-based environment significantly enhanced interest in the topic and overall performance in the course. Conclusion. The elective course on emerging infectious diseases provided in-depth exposure to disease topics normally not encountered in the pharmacy curriculum. Learners found the material and format valuable, and the course enhanced their appreciation of infectious diseases, research methodology, critical thinking and analysis, and their roles as pharmacists. PMID:26430268

  13. Learners' Satisfaction Level with Online Student Portal as a Support System in an Open and Distance eLearning Environment (ODeL)

    ERIC Educational Resources Information Center

    Secreto, Percia V.; Pamulaklakin, Rhodora L.

    2015-01-01

    Learner support in an open, distance and online learning is defined as "all activities and elements in education that respond to a known learner or group of learners, and which are designed to assist in the cognitive, affective, and systemic realms of the learning process" (Brindley, et. al, 2004). Teaching and tutoring, advising and…

  14. GIT2 Acts as a Systems-Level Coordinator of Neurometabolic Activity and Pathophysiological Aging.

    PubMed

    Martin, Bronwen; Chadwick, Wayne; Janssens, Jonathan; Premont, Richard T; Schmalzigaug, Robert; Becker, Kevin G; Lehrmann, Elin; Wood, William H; Zhang, Yongqing; Siddiqui, Sana; Park, Sung-Soo; Cong, Wei-Na; Daimon, Caitlin M; Maudsley, Stuart

    2015-01-01

    Aging represents one of the most complicated and highly integrated somatic processes. Healthy aging is suggested to rely upon the coherent regulation of hormonal and neuronal communication between the central nervous system and peripheral tissues. The hypothalamus is one of the main structures in the body responsible for sustaining an efficient interaction between energy balance and neurological activity and therefore likely coordinates multiple systems in the aging process. We previously identified, in hypothalamic and peripheral tissues, the G protein-coupled receptor kinase interacting protein 2 (GIT2) as a stress response and aging regulator. As metabolic status profoundly affects aging trajectories, we investigated the role of GIT2 in regulating metabolic activity. We found that genomic deletion of GIT2 alters hypothalamic transcriptomic signatures related to diabetes and metabolic pathways. Deletion of GIT2 reduced whole animal respiratory exchange ratios away from those related to primary glucose usage for energy homeostasis. GIT2 knockout (GIT2KO) mice demonstrated lower insulin secretion levels, disruption of pancreatic islet beta cell mass, elevated plasma glucose, and insulin resistance. High-dimensionality transcriptomic signatures from islets isolated from GIT2KO mice indicated a disruption of beta cell development. Additionally, GIT2 expression was prematurely elevated in pancreatic and hypothalamic tissues from diabetic-state mice (db/db), compared to age-matched wild type (WT) controls, further supporting the role of GIT2 in metabolic regulation and aging. We also found that the physical interaction of pancreatic GIT2 with the insulin receptor and insulin receptor substrate 2 was diminished in db/db mice compared to WT mice. Therefore, GIT2 appears to exert a multidimensional "keystone" role in regulating the aging process by coordinating somatic responses to energy deficits. PMID:26834700

  15. GIT2 Acts as a Systems-Level Coordinator of Neurometabolic Activity and Pathophysiological Aging

    PubMed Central

    Martin, Bronwen; Chadwick, Wayne; Janssens, Jonathan; Premont, Richard T.; Schmalzigaug, Robert; Becker, Kevin G.; Lehrmann, Elin; Wood, William H.; Zhang, Yongqing; Siddiqui, Sana; Park, Sung-Soo; Cong, Wei-na; Daimon, Caitlin M.; Maudsley, Stuart

    2016-01-01

    Aging represents one of the most complicated and highly integrated somatic processes. Healthy aging is suggested to rely upon the coherent regulation of hormonal and neuronal communication between the central nervous system and peripheral tissues. The hypothalamus is one of the main structures in the body responsible for sustaining an efficient interaction between energy balance and neurological activity and therefore likely coordinates multiple systems in the aging process. We previously identified, in hypothalamic and peripheral tissues, the G protein-coupled receptor kinase interacting protein 2 (GIT2) as a stress response and aging regulator. As metabolic status profoundly affects aging trajectories, we investigated the role of GIT2 in regulating metabolic activity. We found that genomic deletion of GIT2 alters hypothalamic transcriptomic signatures related to diabetes and metabolic pathways. Deletion of GIT2 reduced whole animal respiratory exchange ratios away from those related to primary glucose usage for energy homeostasis. GIT2 knockout (GIT2KO) mice demonstrated lower insulin secretion levels, disruption of pancreatic islet beta cell mass, elevated plasma glucose, and insulin resistance. High-dimensionality transcriptomic signatures from islets isolated from GIT2KO mice indicated a disruption of beta cell development. Additionally, GIT2 expression was prematurely elevated in pancreatic and hypothalamic tissues from diabetic-state mice (db/db), compared to age-matched wild type (WT) controls, further supporting the role of GIT2 in metabolic regulation and aging. We also found that the physical interaction of pancreatic GIT2 with the insulin receptor and insulin receptor substrate 2 was diminished in db/db mice compared to WT mice. Therefore, GIT2 appears to exert a multidimensional “keystone” role in regulating the aging process by coordinating somatic responses to energy deficits. PMID:26834700

  16. PPARδ Activation Acts Cooperatively with 3-Phosphoinositide-Dependent Protein Kinase-1 to Enhance Mammary Tumorigenesis

    PubMed Central

    Pollock, Claire B.; Yin, Yuzhi; Yuan, Hongyan; Zeng, Xiao; King, Sruthi; Li, Xin; Kopelovich, Levy; Albanese, Chris; Glazer, Robert I.

    2011-01-01

    Peroxisome proliferator-activated receptorδ (PPARδ) is a transcription factor that is associated with metabolic gene regulation and inflammation. It has been implicated in tumor promotion and in the regulation of 3-phosphoinositide-dependent kinase-1 (PDK1). PDK1 is a key regulator of the AGC protein kinase family, which includes the proto-oncogene AKT/PKB implicated in several malignancies, including breast cancer. To assess the role of PDK1 in mammary tumorigenesis and its interaction with PPARδ, transgenic mice were generated in which PDK1 was expressed in mammary epithelium under the control of the MMTV enhancer/promoter region. Transgene expression increased pT308AKT and pS9GSK3β, but did not alter phosphorylation of mTOR, 4EBP1, ribosomal protein S6 and PKCα. The transgenic mammary gland also expressed higher levels of PPARδ and a gene expression profile resembling wild-type mice maintained on a diet containing the PPARδ agonist, GW501516. Both wild-type and transgenic mice treated with GW501516 exhibited accelerated rates of tumor formation that were more pronounced in transgenic animals. GW501516 treatment was accompanied by a distinct metabolic gene expression and metabolomic signature that was not present in untreated animals. GW501516-treated transgenic mice expressed higher levels of fatty acid and phospholipid metabolites than treated wild-type mice, suggesting the involvement of PDK1 in enhancing PPARδ-driven energy metabolism. These results reveal that PPARδ activation elicits a distinct metabolic and metabolomic profile in tumors that is in part related to PDK1 and AKT signaling. PMID:21297860

  17. Msn2p/Msn4p act as a key transcriptional activator of yeast cytoplasmic thiol peroxidase II.

    PubMed

    Hong, Seung-Keun; Cha, Mee-Kyung; Choi, Yong-Soo; Kim, Won-Cheol; Kim, Il-Han

    2002-04-01

    We observed that the transcription of Saccharomyces cerevisiae cytoplasmic thiol peroxidase type II (cTPx II) (YDR453C) is regulated in response to various stresses (e.g. oxidative stress, carbon starvation, and heat-shock). It has been suggested that both transcription-activating proteins, Yap1p and Skn7p, regulate the transcription of cTPx II upon exposure to oxidative stress. However, a dramatic loss of transcriptional response to various stresses in yeast mutant strains lacking both Msn2p and Msn4p suggests that the transcription factors act as a principal transcriptional activator. In addition to two Yap1p response elements (YREs), TTACTAA and TTAGTAA, the presence of two stress response elements (STREs) (CCCCT) in the upstream sequence of cTPx II also suggests that Msn2p/Msn4p could control stress-induced expression of cTPx II. Analysis of the transcriptional activity of site-directed mutagenesis of the putative STREs (STRE1 and STRE2) and YREs (TRE1 and YRE2) in terms of the activity of a lacZ reporter gene under control of the cTPx II promoter indicates that STRE2 acts as a principal binding element essential for transactivation of the cTPx II promoter. The transcriptional activity of the cTPx II promoter was exponentially increased after postdiauxic growth. The transcriptional activity of the cTPx II promoter is greatly increased by rapamycin. Deletion of Tor1, Tor2, Ras1, and Ras2 resulted in a considerable induction when compared with their parent strains, suggesting that the transcription of cTPx II is under negative control of the Ras/cAMP and target of rapamycin signaling pathways. Taken together, these results suggest that cTPx II is a target of Msn2p/Msn4p transcription factors under negative control of the Ras-protein kinase A and target of rapamycin signaling pathways. Furthermore, the accumulation of cTPx II upon exposure to oxidative stress and during the postdiauxic shift suggests an important antioxidant role in stationary phase yeast cells

  18. Integrated Application of Active Controls (IAAC) technology to an advanced subsonic transport project. ACT/Control/Guidance System study, volume 1

    NASA Technical Reports Server (NTRS)

    1982-01-01

    The active control technology (ACT) control/guidance system task of the integrated application of active controls (IAAC) technology project within the NASA energy efficient transport program was documented. The air traffic environment of navigation and air traffic control systems and procedures were extrapolated. An approach to listing flight functions which will be performed by systems and crew of an ACT configured airplane of the 1990s, and a determination of function criticalities to safety of flight, are the basis of candidate integrated ACT/Control/Guidance System architecture. The system mechanizes five active control functions: pitch augmented stability, angle of attack limiting, lateral/directional augmented stability, gust load alleviation, and maneuver load control. The scope and requirements of a program for simulating the integrated ACT avionics and flight deck system, with pilot in the loop, are defined, system and crew interface elements are simulated, and mechanization is recommended. Relationships between system design and crew roles and procedures are evaluated.

  19. Clarin-1 acts as a modulator of mechanotransduction activity and presynaptic ribbon assembly.

    PubMed

    Ogun, Oluwatobi; Zallocchi, Marisa

    2014-11-10

    Clarin-1 is a four-transmembrane protein expressed by hair cells and photoreceptors. Mutations in its corresponding gene are associated with Usher syndrome type 3, characterized by late-onset and progressive hearing and vision loss in humans. Mice carrying mutations in the clarin-1 gene have hair bundle dysmorphology and a delay in synapse maturation. In this paper, we examined the expression and function of clarin-1 in zebrafish hair cells. We observed protein expression as early as 1 d postfertilization. Knockdown of clarin-1 resulted in inhibition of FM1-43 incorporation, shortening of the kinocilia, and mislocalization of ribeye b clusters. These phenotypes were fully prevented by co-injection with clarin-1 transcript, requiring its C-terminal tail. We also observed an in vivo interaction between clarin-1 and Pcdh15a. Altogether, our results suggest that clarin-1 is functionally important for mechanotransduction channel activity and for proper localization of synaptic components, establishing a critical role for clarin-1 at the apical and basal poles of hair cells. PMID:25365995

  20. Function coupling of otoferlin with GAD65 acts to modulate GABAergic activity.

    PubMed

    Wu, Wu; Rahman, Mona N; Guo, Jun; Roy, Natalie; Xue, Lihua; Cahill, Catherine M; Zhang, Shetuan; Jia, Zongchao

    2015-04-01

    Otoferlin, an integral membrane protein implicated in a late stage of exocytosis, has been reported to play a critical role in hearing although the underlying mechanisms remain elusive. However, its widespread tissue distribution infers a more ubiquitous role in synaptic vesicle trafficking. Glutamate, an excitatory neurotransmitter, is converted to its inhibitory counterpart, γ-aminobutyric acid (GABA), by L-glutamic acid decarboxylase (GAD), which exists in soluble (GAD67) and membrane-bound (GAD65) forms. For the first time, we have revealed a close association between otoferlin and GAD65 in both HEK293 and neuronal cells, including SH-SY5Y neuroblastoma and primary rat hippocampus cells, showing a direct interaction between GAD65 and otoferlin's C2 domains. In primary rat hippocampus cells, otoferlin and GAD65 co-localized in a punctate pattern within the cell body, as well as in the axon along the path of vesicular traffic. Significantly, GABA is virtually abolished in otoferlin-knockdown neuronal cells whereas otoferlin overexpression markedly increases endogenous GABA. GABA attenuation in otoferlin-knockdown primary cells is correlated with diminished L-type calcium current. This previously unknown and close correlation demonstrates that otoferlin, through GAD65, modulates GABAergic activity. The discovery of otoferlin-GAD65 functional coupling provides a new avenue for understanding the molecular mechanism by which otoferlin functions in neurological pathways. PMID:25701657

  1. Screening of plants acting against Heterometrus laoticus scorpion venom activity on fibroblast cell lysis.

    PubMed

    Uawonggul, Nunthawun; Chaveerach, Arunrat; Thammasirirak, Sompong; Arkaravichien, Tarinee; Chuachan, Chattong; Daduang, Sakda

    2006-01-16

    The aqueous extracts of 64 plant species, listed as animal- or insect-bite antidotes in old Thai drug recipes were screened for their activity against fibroblast cell lysis after Heterometrus laoticus scorpion venom treatment. The venom was preincubated with plant extract for 30 min and furthered treated to confluent fibroblast cells for 30 min. More than 40% efficiency (test/control) was obtained from cell treatment with venom preincubated with extracts of Andrographis paniculata Nees (Acanthaceae), Barringtonia acutangula (L.) Gaertn. (Lecythidaceae), Calamus sp. (Palmae), Clinacanthus nutans Lindau (Acanthaceae), Euphorbia neriifolia L. (Euphorbiaceae), Ipomoea aquatica Forssk (Convolvulaceae), Mesua ferrea L. (Guttiferae), Passiflora laurifolia L. (Passifloraceae), Plectranthus amboinicus (Lour.) Spreng. (Labiatae), Ricinus communis L. (Euphorbiaceae), Rumex sp. (Polygonaceae) and Sapindus rarak DC. (Sapindaceae), indicating that they had a tendency to be scorpion venom antidotes. However, only Andrographis paniculata and Barringtonia acutangula extracts provided around 50% viable cells from extract treatments without venom preincubation. These two plant extracts are expected to be scorpion venom antidotes with low cytotoxicity. PMID:16169172

  2. Differences in HIV knowledge and sexual practices of learners with intellectual disabilities and non-disabled learners in Nigeria

    PubMed Central

    Aderemi, Toyin J; Pillay, Basil J; Esterhuizen, Tonya M

    2013-01-01

    Introduction Individuals with intellectual disabilities are rarely targeted by the current human immunodeficiency virus (HIV) response, thereby reducing their access to HIV information and services. Currently, little is known about the HIV knowledge and sexual practices of young Nigerians with intellectual disabilities. Thus, this study sought to compare the HIV knowledge and sexual practices of learners with mild/moderate intellectual disabilities and non-disabled learners (NDL) in Nigeria. Findings could help in the development of HIV interventions that are accessible to Nigerian learners with intellectual impairments. Methods This cross-sectional, comparative study utilized a survey to investigate HIV knowledge and sexual practices among learners with mild/moderate intellectual disabilities and NDL in Nigeria. Learners with mild/moderate intellectual disabilities (n=300) and NDL (n=300) within the age range of 12 to 19 years drawn from schools across Oyo State, Nigeria, completed a structured questionnaire to assess their knowledge of HIV transmission and sexual practices. Results Significantly more learners with mild/moderate intellectual disabilities (62.2%) than NDL 48 (37.8%) reported having sexual experience (p=0.002). Of the sexually experienced female learners with mild/moderate intellectual disabilities, 28 (68.3%) reported history of rape compared with 9 (2.9%) of female NDL (p=0.053). Intellectual impairment was significantly associated with lower HIV transmission knowledge scores (p<0.001). Learners with mild/moderate intellectual disabilities were less likely than NDL (p<0.001) to have heard about HIV from most of the common sources of HIV information. In addition, when compared with non-disabled learners, learners with mild/moderate intellectual disabilities were significantly more likely to have reported inconsistent condom use with boyfriends/girlfriends (p<0.001), with casual sexual partners (p<0.001) and non-use of condom during last sexual

  3. Identification of positive-acting domains in GCN2 protein kinase required for translational activation of GCN4 expression

    SciTech Connect

    Wek, R.C.; Ramirez, M.; Jackson, B.M.; Hinnebusch, A.G. )

    1990-06-01

    GCN4 is a transcriptional activator of amino acid-biosynthetic genes in the yeast {ital Saccharomyces cerevisiae}. GCN2, a translational activator of {ital GCN4} expression, contains a domain homologous to the catalytic subunit of eukaryotic protein kinases. Substitution of a highly conserved lysine residue in the kinase domain abolished GCN2 regulatory function in vivo and its ability to autophosphorylate in vitro, indicating that GCN2 acts as a protein kinase in stimulating {ital GCN4} expression. Elevated {ital GCN2} gene dosage led to depression of {ital GCN4} under nonstarvation conditions; however, the authors found that {ital GCN2} mRNA and protein levels did not increase in wild-type cells in response to amino acid starvation. Therefore, it appears that GCN2 protein kinase function is stimulated postranslationally in amino acid-starved cells. Three dominant-constitutive {ital GCN2} point mutations were isolated that led to derepressed {ital GCN4} expression under nonstarvation conditions. Two of the {ital GCN2}(Con) mutations mapped in the kinase domain itself. The third mapped just downstream from a carboxyl-terminal segment homologous to histidyl-tRNA synthetase (HisRS), which the authors suggest might function to detect uncharged tRNA in amino acid-starved cells and activate the adjacent protein kinase moiety.

  4. β-Glucuronidase activity and mitochondrial dysfunction: the sites where flavonoid glucuronides act as anti-inflammatory agents

    PubMed Central

    Kawai, Yoshichika

    2014-01-01

    Epidemiological and experimental studies suggest that the consumption of flavonoid-rich diets decreases the risk of various chronic diseases such as cardiovascular diseases. Although studies on the bioavailability of flavonoids have been well-characterized, the tissue and cellular localizations underlying their biological mechanisms are largely unknown. The development and application of novel monoclonal antibodies revealed that macrophages could be the major target of dietary flavonoids in vivo. Using macrophage-like cell lines in vitro, we examined the molecular basis of the interaction between the macrophages and flavonoids, especially the glucuronide metabolites. We have found that extracellular β-glucuronidase secreted from macrophages is essential for the bioactivation of the glucuronide conjugates into the aglycone, and that the enzymatic activity, which requires an acidic pH, is promoted by the increased secretion of lactate in response to the mitochondrial dysfunction. This review describes our recent findings indicating the molecular mechanisms responsible for the anti-inflammatory activity of dietary flavonoids within the inflammation sites. We propose that the extracellular activity of β-glucuronidase associated with the status of the mitochondrial function in the target cells might be important biomarkers for the specific sites where the glucuronides of dietary flavonoids can act as anti-atherosclerotic and anti-inflammatory agents in vivo. PMID:24895476

  5. Histone Methyltransferase Inhibitors Are Orally Bioavailable, Fast-Acting Molecules with Activity against Different Species Causing Malaria in Humans

    PubMed Central

    Sundriyal, Sandeep; Caron, Joachim; Chen, Patty; Witkowski, Benoit; Menard, Didier; Suwanarusk, Rossarin; Renia, Laurent; Nosten, Francois; Jiménez-Díaz, María Belén; Angulo-Barturen, Iñigo; Martínez, María Santos; Ferrer, Santiago; Sanz, Laura M.; Gamo, Francisco-Javier; Wittlin, Sergio; Duffy, Sandra; Avery, Vicky M.; Ruecker, Andrea; Delves, Michael J.; Sinden, Robert E.; Fuchter, Matthew J.

    2014-01-01

    Current antimalarials are under continuous threat due to the relentless development of drug resistance by malaria parasites. We previously reported promising in vitro parasite-killing activity with the histone methyltransferase inhibitor BIX-01294 and its analogue TM2-115. Here, we further characterize these diaminoquinazolines for in vitro and in vivo efficacy and pharmacokinetic properties to prioritize and direct compound development. BIX-01294 and TM2-115 displayed potent in vitro activity, with 50% inhibitory concentrations (IC50s) of <50 nM against drug-sensitive laboratory strains and multidrug-resistant field isolates, including artemisinin-refractory Plasmodium falciparum isolates. Activities against ex vivo clinical isolates of both P. falciparum and Plasmodium vivax were similar, with potencies of 300 to 400 nM. Sexual-stage gametocyte inhibition occurs at micromolar levels; however, mature gametocyte progression to gamete formation is inhibited at submicromolar concentrations. Parasite reduction ratio analysis confirms a high asexual-stage rate of killing. Both compounds examined displayed oral efficacy in in vivo mouse models of Plasmodium berghei and P. falciparum infection. The discovery of a rapid and broadly acting antimalarial compound class targeting blood stage infection, including transmission stage parasites, and effective against multiple malaria-causing species reveals the diaminoquinazoline scaffold to be a very promising lead for development into greatly needed novel therapies to control malaria. PMID:25421480

  6. Histone methyltransferase inhibitors are orally bioavailable, fast-acting molecules with activity against different species causing malaria in humans.

    PubMed

    Malmquist, Nicholas A; Sundriyal, Sandeep; Caron, Joachim; Chen, Patty; Witkowski, Benoit; Menard, Didier; Suwanarusk, Rossarin; Renia, Laurent; Nosten, Francois; Jiménez-Díaz, María Belén; Angulo-Barturen, Iñigo; Santos Martínez, María; Ferrer, Santiago; Sanz, Laura M; Gamo, Francisco-Javier; Wittlin, Sergio; Duffy, Sandra; Avery, Vicky M; Ruecker, Andrea; Delves, Michael J; Sinden, Robert E; Fuchter, Matthew J; Scherf, Artur

    2015-02-01

    Current antimalarials are under continuous threat due to the relentless development of drug resistance by malaria parasites. We previously reported promising in vitro parasite-killing activity with the histone methyltransferase inhibitor BIX-01294 and its analogue TM2-115. Here, we further characterize these diaminoquinazolines for in vitro and in vivo efficacy and pharmacokinetic properties to prioritize and direct compound development. BIX-01294 and TM2-115 displayed potent in vitro activity, with 50% inhibitory concentrations (IC50s) of <50 nM against drug-sensitive laboratory strains and multidrug-resistant field isolates, including artemisinin-refractory Plasmodium falciparum isolates. Activities against ex vivo clinical isolates of both P. falciparum and Plasmodium vivax were similar, with potencies of 300 to 400 nM. Sexual-stage gametocyte inhibition occurs at micromolar levels; however, mature gametocyte progression to gamete formation is inhibited at submicromolar concentrations. Parasite reduction ratio analysis confirms a high asexual-stage rate of killing. Both compounds examined displayed oral efficacy in in vivo mouse models of Plasmodium berghei and P. falciparum infection. The discovery of a rapid and broadly acting antimalarial compound class targeting blood stage infection, including transmission stage parasites, and effective against multiple malaria-causing species reveals the diaminoquinazoline scaffold to be a very promising lead for development into greatly needed novel therapies to control malaria. PMID:25421480

  7. Transcription factors GAF and HSF act at distinct regulatory steps to modulate stress-induced gene activation

    PubMed Central

    Fuda, Nicholas J.; Mahat, Dig B.; Core, Leighton J.; Guertin, Michael J.

    2016-01-01

    The coordinated regulation of gene expression at the transcriptional level is fundamental to development and homeostasis. Inducible systems are invaluable when studying transcription because the regulatory process can be triggered instantaneously, allowing the tracking of ordered mechanistic events. Here, we use precision run-on sequencing (PRO-seq) to examine the genome-wide heat shock (HS) response in Drosophila and the function of two key transcription factors on the immediate transcription activation or repression of all genes regulated by HS. We identify the primary HS response genes and the rate-limiting steps in the transcription cycle that GAGA-associated factor (GAF) and HS factor (HSF) regulate. We demonstrate that GAF acts upstream of promoter-proximally paused RNA polymerase II (Pol II) formation (likely at the step of chromatin opening) and that GAF-facilitated Pol II pausing is critical for HS activation. In contrast, HSF is dispensable for establishing or maintaining Pol II pausing but is critical for the release of paused Pol II into the gene body at a subset of highly activated genes. Additionally, HSF has no detectable role in the rapid HS repression of thousands of genes. PMID:27492368

  8. Investigating science teacher knowledge of learners and learning and sequence of instruction in an alternative certification program

    NASA Astrophysics Data System (ADS)

    Brown, Patrick L.

    Alternative certification programs (ACPs) have been designed to address the teacher shortage and still meet the goals of science literacy by creating highly qualified teachers. However, science education researchers know little about the development of teacher knowledge during an ACP. The purpose of this study was to investigate how science teacher knowledge of learners and lesson structure develops in an ACP. Data sources included a lesson planning task at the beginning of the program, interviews after the first summer of ACP coursework, and an interview-observation cycle during the teacher's first semester teaching. I constructed profiles of four individuals and generated a set of assertions from a cross-case analysis. The four prospective teachers developed knowledge of learners from their experiences in the Secondary Science Methods courses, from their mentor teacher, and from working with students. Their ideas about the requirements for learning science and areas of student difficulties expanded from teaching and experiences in the Science Methods courses. The teachers consistently sequenced instruction in ways that gave priority to "inform" types of instruction. They used lectures and teacher-led discussions during inform types of instruction to transmit knowledge to students. Over time, teachers integrated their knowledge of learners and sequence of science instruction. For the teachers, the integration of knowledge of instructional sequences and learners meant that they purposefully added "practice" types of activities to help students learn terms and concepts. ACP teachers' science teaching orientations were complex, consisting of multiple dimensions. Although each teacher added goals and/or views of the teacher's role, their science teaching orientations were highly resistant to change. Prospective teachers' science teaching orientations acted as a filter for making sense of experiences in the ACP. Three of the teachers embraced experiences and knowledge

  9. Effective instruction for English learners.

    PubMed

    Calderón, Margarita; Slavin, Robert; Sánchez, Marta

    2011-01-01

    The fastest-growing student population in U.S. schools today is children of immigrants, half of whom do not speak English fluently and are thus labeled English learners. Although the federal government requires school districts to provide services to English learners, it offers states no policies to follow in identifying, assessing, placing, or instructing them. Margarita Calderón, Robert Slavin, and Marta Sánchez identify the elements of effective instruction and review a variety of successful program models. During 2007-08, more than 5.3 million English learners made up 10.6 percent of the nation's K-12 public school enrollment. Wide and persistent achievement disparities between these English learners and English-proficient students show clearly, say the authors, that schools must address the language, literacy, and academic needs of English learners more effectively. Researchers have fiercely debated the merits of bilingual and English-only reading instruction. In elementary schools, English learners commonly receive thirty minutes of English as a Second Language (ESL) instruction but attend general education classes for the rest of the day, usually with teachers who are unprepared to teach them. Though English learners have strikingly diverse levels of skills, in high school they are typically lumped together, with one teacher to address their widely varying needs. These in-school factors contribute to the achievement disparities. Based on the studies presented here, Calderón, Slavin, and Sánchez assert that the quality of instruction is what matters most in educating English learners. They highlight comprehensive reform models, as well as individual components of these models: school structures and leadership; language and literacy instruction; integration of language, literacy, and content instruction in secondary schools; cooperative learning; professional development; parent and family support teams; tutoring; and monitoring implementation and outcomes

  10. Interaction of African American Learners Online: An Adult Education Perspective

    ERIC Educational Resources Information Center

    Kang, Haijun; Yang, Yang

    2016-01-01

    This study examines how various life factors and personal attributes affect African American adult learners' use of the three types of learning interaction-learner-content, learner-instructor, and learner-learner. Multivariate multiple regression analyses were used. The aggregate effect of life factors on African American adult learners' use of…

  11. Access, Consider, Teach: ACT in Your Classroom

    ERIC Educational Resources Information Center

    Stanford, Pokey; Reeves, Stacy

    2007-01-01

    University teachers who are teacher educators cannot connect to "The Millennial Generation" of today's preservice learners by using chalk and dull outdated textbooks. When university professionals access the technology available, consider the curriculum, and teach with technology (ACT) undergraduate teacher candidates acquire the vision of…

  12. The Effects of Instructor-Learner Interactions on Learner Satisfaction in Online Masters Courses

    ERIC Educational Resources Information Center

    McLaren, Angelene C.

    2010-01-01

    The purpose of this research study was to investigate the extent instructor-learner interactions affected learner satisfaction in online, semester-long Masters courses. This research study lent itself to several questions: To what extent do instructor-learner interactions affect learner satisfaction in online Masters courses; To what extent does…

  13. Teacher Perceptions of Learner-Learner Engagement at a Cyber High School

    ERIC Educational Resources Information Center

    Borup, Jered

    2016-01-01

    Distance education has historically contained little or no learner-learner interactions. Currently the Internet allows for unprecedented levels of learner-learner interaction and has the potential to transform how students learn online. However, many courses offered online focus more on flexibility and independence than on interaction and…

  14. Study Partners Recommendation for xMOOCs Learners

    PubMed Central

    Xu, Bin; Yang, Dan

    2015-01-01

    Massive open online courses (MOOCs) provide an opportunity for people to access free courses offered by top universities in the world and therefore attracted great attention and engagement from college teachers and students. However, with contrast to large scale enrollment, the completion rate of these courses is really low. One of the reasons for students to quit learning process is problems which they face that could not be solved by discussing them with classmates. In order to keep them staying in the course, thereby further improving the completion rate, we address the task of study partner recommendation for students based on both content information and social network information. By analyzing the content of messages posted by learners in course discussion forum, we investigated the learners' behavior features to classify the learners into three groups. Then we proposed a topic model to measure learners' course knowledge awareness. Finally, a social network was constructed based on their activities in the course forum, and the relationship in the network was then employed to recommend study partners for target learner combined with their behavior features and course knowledge awareness. The experiment results show that our method achieves better performance than recommending method only based on content information. PMID:25663836

  15. Study Partners Recommendation for xMOOCs learners.

    PubMed

    Xu, Bin; Yang, Dan

    2015-01-01

    Massive open online courses (MOOCs) provide an opportunity for people to access free courses offered by top universities in the world and therefore attracted great attention and engagement from college teachers and students. However, with contrast to large scale enrollment, the completion rate of these courses is really low. One of the reasons for students to quit learning process is problems which they face that could not be solved by discussing them with classmates. In order to keep them staying in the course, thereby further improving the completion rate, we address the task of study partner recommendation for students based on both content information and social network information. By analyzing the content of messages posted by learners in course discussion forum, we investigated the learners' behavior features to classify the learners into three groups. Then we proposed a topic model to measure learners' course knowledge awareness. Finally, a social network was constructed based on their activities in the course forum, and the relationship in the network was then employed to recommend study partners for target learner combined with their behavior features and course knowledge awareness. The experiment results show that our method achieves better performance than recommending method only based on content information. PMID:25663836

  16. Explicit and Implicit Feedback, Modified Output, and SLA: Does Explicit and Implicit Feedback Promote Learning and Learner-Learner Interactions?

    ERIC Educational Resources Information Center

    Adams, Rebecca; Nuevo, Ana Maria; Egi, Takako

    2011-01-01

    Research on interactional feedback has typically focused on feedback learners receive from native speakers (i.e., NS-learner contexts). However, for many second language (L2) learners, the majority of their opportunities to engage in interaction occur with other learners (i.e., learner-learner contexts). The literature has suggested that feedback…

  17. Integrated Application of Active Controls (IAAC) technology to an advanced subsonic transport project: Current and advanced act control system definition study. Volume 2: Appendices

    NASA Technical Reports Server (NTRS)

    Hanks, G. W.; Shomber, H. A.; Dethman, H. A.; Gratzer, L. B.; Maeshiro, A.; Gangsaas, D.; Blight, J. D.; Buchan, S. M.; Crumb, C. B.; Dorwart, R. J.

    1981-01-01

    The current status of the Active Controls Technology (ACT) for the advanced subsonic transport project is investigated through analysis of the systems technical data. Control systems technologies under examination include computerized reliability analysis, pitch axis fly by wire actuator, flaperon actuation system design trade study, control law synthesis and analysis, flutter mode control and gust load alleviation analysis, and implementation of alternative ACT systems. Extensive analysis of the computer techniques involved in each system is included.

  18. Identification of a Caulobacter basal body structural gene and a cis-acting site required for activation of transcription.

    PubMed Central

    Dingwall, A; Gober, J W; Shapiro, L

    1990-01-01

    The genes that encode the components and regulatory proteins of the Caulobacter crescentus flagellum are transcribed at specific times in the cell cycle. One of these genes, flbN, is required early in the flagellar assembly process. The flbN gene was cloned and sequenced, and the time of transcription activation was determined. The derived amino acid sequence indicates that fibN encodes a 25-kilodalton protein with a cleavable leader peptide. The flbN-encoded protein has 30.8% identity with the protein encoded by the Salmonella typhimurium basal body L-ring gene, flgH. Site-directed mutagenesis and gel mobility shift assays identified a binding site at -100 from the transcription start site for a trans-acting protein, RF-2, that functions to partially activate flbN transcription at a defined time in the cell cycle. The RF-2 binding region is similar to a NifA binding site normally used in the activation of some sigma 54 promoters involved in nitrogen fixation in other bacteria. Transcription of a flbN-reporter gene fusion in an Escherichia coli background was dependent on the presence of a NifA transcription factor supplied by a plasmid-borne Rhizobium meliloti gene encoding NifA. A deletion or base changes in the RF-2 binding region eliminated expression of the flbN gene in E. coli even when a NifA protein was provided in trans, suggesting that a sigma 54 promoter with an upstream activator element is used by the C. crescentus flbN gene. A consensus sequence for a sigma 54 promoter was found at the appropriate distance 5' to one of two identified transcription start sites. Site-directed mutagenesis confirmed that a conserved nucleotide in this sigma 54 promoter consensus sequence was required for transcription. Deletion of the region 5' to the apparent sigma 54 promoter caused a complete loss of transcription activation. Transcription activation of flbN in C. crescentus involves the combination of several elements: the NifA-like site is required for full

  19. The long noncoding RNA Six3OS acts in trans to regulate retinal development by modulating Six3 activity

    PubMed Central

    2011-01-01

    Background Thousands of different long non-coding RNAs are expressed during embryonic development, but the function of these molecules remains largely unexplored. Results Here we characterize the expression and function of Six3OS, a long non-coding RNA that is transcribed from the distal promoter region of the gene encoding the homeodomain transcription factor Six3. Overexpression and knockdown analysis of Six3OS reveals that it plays an essential role in regulating retinal cell specification. We further observe that Six3OS regulates Six3 activity in developing retina, but does not do so by modulating Six3 expression. Finally, we show that Six3OS binds directly to Ezh2 and Eya family members, indicating that Six3OS can act as a molecular scaffold to recruit histone modification enzymes to Six3 target genes. Conclusions Our findings demonstrate a novel mechanism by which promoter-associated long non-coding RNAs can modulate the activity of their associated protein coding genes, and highlight the importance of this diverse class of molecules in the control of neural development. PMID:21936910

  20. DCA1 Acts as a Transcriptional Co-activator of DST and Contributes to Drought and Salt Tolerance in Rice.

    PubMed

    Cui, Long-Gang; Shan, Jun-Xiang; Shi, Min; Gao, Ji-Ping; Lin, Hong-Xuan

    2015-10-01

    Natural disasters, including drought and salt stress, seriously threaten food security. In previous work we cloned a key zinc finger transcription factor gene, Drought and Salt Tolerance (DST), a negative regulator of drought and salt tolerance that controls stomatal aperture in rice. However, the exact mechanism by which DST regulates the expression of target genes remains unknown. In the present study, we demonstrated that DST Co-activator 1 (DCA1), a previously unknown CHY zinc finger protein, acts as an interacting co-activator of DST. DST was found to physically interact with itself and to form a heterologous tetramer with DCA1. This transcriptional complex appears to regulate the expression of peroxidase 24 precursor (Prx 24), a gene encoding an H2O2 scavenger that is more highly expressed in guard cells. Downregulation of DCA1 significantly enhanced drought and salt tolerance in rice, and overexpression of DCA1 increased sensitivity to stress treatment. These phenotypes were mainly influenced by DCA1 and negatively regulated stomatal closure through the direct modulation of genes associated with H2O2 homeostasis. Our findings establish a framework for plant drought and salt stress tolerance through the DCA1-DST-Prx24 pathway. Moreover, due to the evolutionary and functional conservation of DCA1 and DST in plants, engineering of this pathway has the potential to improve tolerance to abiotic stress in other important crop species. PMID:26496194

  1. DCA1 Acts as a Transcriptional Co-activator of DST and Contributes to Drought and Salt Tolerance in Rice

    PubMed Central

    Cui, Long-Gang; Shan, Jun-Xiang; Shi, Min; Gao, Ji-Ping; Lin, Hong-Xuan

    2015-01-01

    Natural disasters, including drought and salt stress, seriously threaten food security. In previous work we cloned a key zinc finger transcription factor gene, Drought and Salt Tolerance (DST), a negative regulator of drought and salt tolerance that controls stomatal aperture in rice. However, the exact mechanism by which DST regulates the expression of target genes remains unknown. In the present study, we demonstrated that DST Co-activator 1 (DCA1), a previously unknown CHY zinc finger protein, acts as an interacting co-activator of DST. DST was found to physically interact with itself and to form a heterologous tetramer with DCA1. This transcriptional complex appears to regulate the expression of peroxidase 24 precursor (Prx 24), a gene encoding an H2O2 scavenger that is more highly expressed in guard cells. Downregulation of DCA1 significantly enhanced drought and salt tolerance in rice, and overexpression of DCA1 increased sensitivity to stress treatment. These phenotypes were mainly influenced by DCA1 and negatively regulated stomatal closure through the direct modulation of genes associated with H2O2 homeostasis. Our findings establish a framework for plant drought and salt stress tolerance through the DCA1-DST-Prx24 pathway. Moreover, due to the evolutionary and functional conservation of DCA1 and DST in plants, engineering of this pathway has the potential to improve tolerance to abiotic stress in other important crop species. PMID:26496194

  2. Clobetasol and Halcinonide Act as Smoothened Agonists to Promote Myelin Gene Expression and RxRγ Receptor Activation

    PubMed Central

    De Nardis, Velia; Di Giandomenico, Daniele; Lucisano, Giuseppe; Scardapane, Marco; Poma, Anna; Ragnini-Wilson, Antonella

    2015-01-01

    One of the causes of permanent disability in chronic multiple sclerosis patients is the inability of oligodendrocyte progenitor cells (OPCs) to terminate their maturation program at lesions. To identify key regulators of myelin gene expression acting at the last stages of OPC maturation we developed a drug repositioning strategy based on the mouse immortalized oligodendrocyte (OL) cell line Oli-neu brought to the premyelination stage by stably expressing a key factor regulating the last stages of OL maturation. The Prestwick Chemical Library® of 1,200 FDA-approved compound(s) was repositioned at three dosages based on the induction of Myelin Basic Protein (MBP) expression. Drug hits were further validated using dosage-dependent reproducibility tests and biochemical assays. The glucocorticoid class of compounds was the most highly represented and we found that they can be divided in three groups according to their efficacy on MBP up-regulation. Since target identification is crucial before bringing compounds to the clinic, we searched for common targets of the primary screen hits based on their known chemical-target interactomes, and the pathways predicted by top ranking compounds were validated using specific inhibitors. Two of the top ranking compounds, Halcinonide and Clobetasol, act as Smoothened (Smo) agonists to up-regulate myelin gene expression in the Oli-neuM cell line. Further, RxRγ activation is required for MBP expression upon Halcinonide and Clobetasol treatment. These data indicate Clobetasol and Halcinonide as potential promyelinating drugs and also provide a mechanistic understanding of their mode of action in the pathway leading to myelination in OPCs. Furthermore, our classification of glucocorticoids with respect to MBP expression provides important novel insights into their effects in the CNS and a rational criteria for their choice in combinatorial therapies in de-myelinating diseases. PMID:26658258

  3. Adult Learner Characteristics and Instructional Objectives.

    ERIC Educational Resources Information Center

    Etter, David Campbell George

    Using 40 male and 40 female part time learners with an average age of 36.6, this program planning study explored relationships between selected learner characteristics and behaviorally stated cognitive instructional objectives (IOs). Variables included age, sex, socioeconomic status, verbal ability, and a measure of learners' goals or learning…

  4. Alternative Model Learner Verification and Revision Statutes.

    ERIC Educational Resources Information Center

    Geffert, Hannah N.; And Others

    A learner verification and revision (LVR) process attempts to discover difficulties learners experience in using instructional materials and to formulate possible ways of modifying the instructional materials to eliminate the difficulties. It is a means of ensuring useful learner input into the prepublication development and postpublication…

  5. An Open Learner Model for Trainee Pilots

    ERIC Educational Resources Information Center

    Gakhal, Inderdip; Bull, Susan

    2008-01-01

    This paper investigates the potential for simple open learner models for highly motivated, independent learners, using the example of trainee pilots. In particular we consider whether such users access their learner model to help them identify their current knowledge level, areas of difficulty and specific misconceptions, to help them plan their…

  6. The Adult Learner: Some Things We Know

    ERIC Educational Resources Information Center

    Fogarty, Robin J.; Pete, Brian M.

    2007-01-01

    This book addresses the "warrior" who rises to the challenge of teaching the adult learner. The discussion is designed as a catalyst for dialogue about the adult learner and to uncover the complexities of teaching this rare and riveting species. This book is organized around three interlocking themes: some things we know about the adult learner;…

  7. Slow Learners: Are Educators Leaving Them Behind?

    ERIC Educational Resources Information Center

    Kaznowski, Kimberly

    2004-01-01

    This study compared the school performance of a sample of slow learners who qualified for special education as learning disabled with a sample of slow learners who did not qualify for special education. The intent of the study was to determine which group of slow learners was more successful in school in order to know if special education or…

  8. Appropriateness and the Foreign-Language Learner.

    ERIC Educational Resources Information Center

    Gannon, Roger E.

    1980-01-01

    The attitude of the target-language community toward the foreign language learner has been overlooked in language teaching. The teacher should consider the native speaker's attitude toward the language learner's command of the language, whether the native speaker views the learner's proficiency as an intrusion, and whether situations dictate…

  9. Becoming a Strategic Language Learner in CALL

    ERIC Educational Resources Information Center

    Cohen, Andrew D.

    2007-01-01

    This article outlines what it means to be a strategic language learner in the context of Computer-Assisted Language Learning (CALL). It looks at the possible roles for language learner strategies at their crucial intersection with language learning technology. We will first consider what language learner strategies have been represented in…

  10. Characteristics of Successful Adult Distance Instructors for Adult Learners

    ERIC Educational Resources Information Center

    Smith, Nora N.

    2003-01-01

    In this age of rapid technological and economic change, life-long learning is becoming a way of life. The average age of students will become greater. Participation in learning activities by learners 18 and over increased from 38 percent in 1991 to 50 percent in 1999 (U.S. Department of Education, NCES, 1999). As the population seeks more…

  11. Curriculum Guides: Programming for the Adult Mentally Handicapped Learner.

    ERIC Educational Resources Information Center

    Klugerman, Phyllis B., Ed.; Toye, Bernadette, Ed.

    This volume includes a series of curricula designed specifically for adult mentally handicapped learners. Addressed in the individual curricula are the following topics: basic skills; bicycle maintenance and repair; manual wheelchair maintenance and repair; personal awareness; social, recreational, and art activity groups; woodworking; and…

  12. A Problem Solving Strategy for Gifted Learners in South Africa.

    ERIC Educational Resources Information Center

    van der Horst, Helen v R.

    2000-01-01

    A strategy of problem solving in the teaching of gifted learners is explored as a possible way of differentiating the curriculum in order to optimize learning. The Teaching Actively in a Social Context Model (TASC) and Renzulli's Enrichment Triad Model are cited as valuable teaching-learning programs. (Contains references.) (Author/CR)

  13. Collaborative Revision in L2 Writing: Learners' Reflections

    ERIC Educational Resources Information Center

    Memari Hanjani, Alireza

    2016-01-01

    L2 learning literature has reflected on the problems surrounding the application of teacher written feedback and peer feedback in EFL contexts. To address the disadvantages of these feedback forms, this exploratory case study examined EFL learners' reactions to a collaborative revision activity. Interview data were collected from eight native…

  14. Language Development for English Language Learners. Facilitator's Guide

    ERIC Educational Resources Information Center

    Rivera, Mabel O.; Moughamian, Ani; Francis, David J.

    2009-01-01

    This Facilitator's Guide has been prepared for presenters of the "Language Development for English Language Learners" professional development module. It accompanies the 67-slide PowerPoint presentation with speaker's notes and contains materials to help prepare for a professional development session, including activity instructions, handouts,…

  15. Understanding the Learner-Environment Relationship: A Matrix of Perspectives

    ERIC Educational Resources Information Center

    Bowler, Josephine; Annan, Jean; Mentis, Mandia

    2007-01-01

    This conceptual article re-examines the contribution of a contextual perspective to the practice of educational psychology. The two dimensions of environment and learner are placed along a continuum of active to passive. A range of theory is then situated within this matrix. The article explains and illustrates how the matrix encompasses different…

  16. Shared Pedagogical Understandings: Schoolwide Inclusion Practices Supporting Learner Needs

    ERIC Educational Resources Information Center

    Abawi, Lindy; Oliver, Mark

    2013-01-01

    Educational perspectives that recommend inclusion of children with special needs into mainstream classrooms remain a controversial topic. The Melbourne Declaration declares that all young Australians should be supported to become successful learners; confident and creative individuals; and active and informed citizens. So the question remains how…

  17. Motivation and Interlanguage Pragmatics in Iranian English Language Learners

    ERIC Educational Resources Information Center

    Khorshidi, Hassan Rasouli; Nimchahi, Abdolreza Bagherzadeh

    2013-01-01

    It is generally believed that interlanguage pragmatics and motivation play important roles in learning. Motivation is important because it determines the extent of the learner's active involvement and attitude toward learning. The major purpose of this study was to investigate the impact of integrative and instrumental motivation on the…

  18. Boosting Language Skills of English Learners through Dramatization and Movement

    ERIC Educational Resources Information Center

    Greenfader, Christa Mulker; Brouillette, Liane

    2013-01-01

    This article presents an arts integration program that uses drama and dance to promote foundational literacy skills, with an emphasis on the oral development of English Language Learners (ELLs). Previous research indicates that arts activities afford a beneficial opportunity for young students to practice language skills, but many teachers have…

  19. Are Online Learners Frustrated with Collaborative Learning Experiences?

    ERIC Educational Resources Information Center

    Capdeferro, Neus; Romero, Margarida

    2012-01-01

    Online education increasingly puts emphasis on collaborative learning methods. Despite the pedagogical advantages of collaborative learning, online learners can perceive collaborative learning activities as frustrating experiences. The purpose of this study was to characterize the feelings of frustration as a negative emotion among online learners…

  20. Learner Experiences in Web-Based Language Learning

    ERIC Educational Resources Information Center

    Son, Jeong-Bae

    2007-01-01

    The World Wide Web offers a global database of authentic materials that can enhance language learning and teaching. This study examines the use of the web for language learning through a study of English as a second language (ESL) learners' experiences in web-based language learning (WBLL) activities in an English language intensive course for…

  1. Interactive TV: An Effective Instructional Mode for Adult Learners

    ERIC Educational Resources Information Center

    Chen, Li-Ling; Iris, Carole

    2004-01-01

    The inclusion of interactive television (iTV) programs for learning is an emerging genre in education. Literature has concluded that any aspect of learning requires some form of interaction or feedback to be most effective. As television (TV) evolves from being a passive to an active medium, it has the potential to engage learners and reach a mass…

  2. Polycomb-group complex 1 acts as an E3 ubiquitin ligase for Geminin to sustain hematopoietic stem cell activity

    PubMed Central

    Ohtsubo, Motoaki; Yasunaga, Shin'ichiro; Ohno, Yoshinori; Tsumura, Miyuki; Okada, Satoshi; Ishikawa, Nobutsune; Shirao, Kenichiro; Kikuchi, Akira; Nishitani, Hideo; Kobayashi, Masao; Takihara, Yoshihiro

    2008-01-01

    Polycomb-group (PcG) genes encode multimeric nuclear protein complexes, PcG complex 1 and 2. PcG complex 2 was proved to induce transcription repression and to further methylate histone H3 at lysine-27 (H3K27). Subsequently PcG complex 1 is recruited through recognition of methylated H3K27 and maintains the transcription silencing by mediating monoubiquitination of histone H2A at lysine-119. Genetic evidence demonstrated a crucial role for PcG complex 1 in stem cells, and Bmi1, a member of PcG complex 1, was shown to sustain adult stem cells through direct repression of the INK4a locus encoding cyclin-dependent kinase inhibitor, p16CKI, and p19ARF. The molecular functions of PcG complex 1, however, remain insufficiently understood. In our study, deficiency of Rae28, a member of PcG complex 1, was found to impair ubiquitin-proteasome-mediated degradation of Geminin, an inhibitor of DNA replication licensing factor Cdt1, and to increase protein stability. The resultant accumulation of Geminin, based on evidence from retroviral transduction experiments, presumably eliminated hematopoietic stem cell activity in Rae28-deficient mice. Rae28 mediates recruiting Scmh1, which provides PcG complex 1 an interaction domain for Geminin. Moreover, PcG complex 1 acts as the E3 ubiquitin ligase for Geminin, as we demonstrated in vivo as well as in vitro by using purified recombinant PcG complex 1 reconstituted in insect cells. Our findings suggest that PcG complex 1 supports the activity of hematopoietic stem cells, in which high-level Geminin expression induces quiescence securing genome stability, by enhancing cycling capability and hematopoietic activity through direct regulation of Geminin. PMID:18650381

  3. Educating Young Children: Active Learning Practices for Preschool and Child Care Programs [and] A Study Guide to Educating Young Children: Exercises for Adult Learners. Second Edition.

    ERIC Educational Resources Information Center

    Hohmann, Mary; Weikart, David P.

    High/Scope preschool curriculum is a model for developing high-quality early childhood programs that encourage and support children's initiatives and active learning experiences. This revised manual for early childhood practitioners and students presents essential strategies adults can use to make active learning a reality in their programs. The…

  4. A Cultural-Historical Activity Theory Investigation of Contradictions in Open and Distance Higher Education among Alienated Adult Learners in Korea National Open University

    ERIC Educational Resources Information Center

    Joo, K. P.

    2014-01-01

    Drawing upon cultural-historical activity theory, this research analyzed the structural contradictions existing in a variety of educational activities among a group of alienated adult students in Korea National Open University (KNOU). Despite KNOU's quantitative development in student enrollment, the contradictions shed light on how the…

  5. The Nuclear Matrix Protein, NRP/B, Acts as a Transcriptional Repressor of E2F-mediated Transcriptional Activity

    PubMed Central

    Choi, Jina; Yang, Eun Sung; Cha, Kiweon; Whang, John; Choi, Woo-Jung; Avraham, Shalom; Kim, Tae-Aug

    2014-01-01

    Background: NRP/B, a family member of the BTB/Kelch repeat proteins, is implicated in neuronal and cancer development, as well as the regulation of oxidative stress responses in breast and brain cancer. Our previous studies indicate that the NRP/B-BTB/POZ domain is involved in the dimerization of NRP/B and in a complex formation with the tumor suppressor, retinoblastoma protein. Although much evidence supports the potential role of NRP/B as a tumor suppressor, the molecular mechanisms of NRP/B action on E2F transcription factors have not been elucidated. Methods: Three-dimensional modeling of NRP/B was used to generate point mutations in the BTB/Kelch domains. Tet-on inducible NRP/B expression was established. The NRP/B deficient breast cancer cell line, MDA-MB-231, was generated using lentiviral shNRP/B to evaluate the effect of NRP/B on cell proliferation, invasion and migration. Immunoprecipitation was performed to verify the interaction of NRP/B with E2F and histone deacetylase (HDAC-1), and the expression level of NRP/B protein was analyzed by Western blot analysis. Changes in cell cycle were determined by flow cytometry. Transcriptional activities of E2F transcription factors were measured by chloramphenicol acetyltransferase (CAT) activity. Results: Ectopic overexpression of NRP/B demonstrated that the NRP/B-BTB/POZ domain plays a critical role in E2F-mediated transcriptional activity. Point mutations within the BTB/POZ domain restored E2-promoter activity inhibited by NRP/B. Loss of NRP/B enhanced the proliferation and migration of breast cancer cells. Endogenous NRP/B interacted with E2F and HDAC1. Treatement with an HDAC inhibitor, trichostatin A (TSA), abolished the NRP/B-mediated suppression of E2-promoter activity. Gain or loss of NRP/B in HeLa cells confirmed the transcriptional repressive capability of NRP/B on the E2F target genes, Cyclin E and HsORC (Homo sapiens Origin Recognition Complex). Conclusions: The present study shows that NRP/B acts as a

  6. Learner-Centered Online Instruction

    ERIC Educational Resources Information Center

    McCombs, Barbara

    2015-01-01

    This chapter offers a theoretical rationale and an explanation of evidence for using research-validated, learner-centered principles and practices in online course development, highlighting the evidence-based practices that have been used successfully to develop online courses that engage and retain students.

  7. Options for English Language Learners

    ERIC Educational Resources Information Center

    Minaya-Rowe, Liliana

    2008-01-01

    Between 69 percent and 90 percent of English language learners (ELLs) in middle and high schools were born in the United States and have been in U.S. schools since kindergarten still have not achieved the academic proficiency to succeed in an all-English mainstream program. Various ELL program options are available for school districts to…

  8. Individual Learner Differences in SLA

    ERIC Educational Resources Information Center

    Arabski, Janusz; Wojtaszek, Adam

    2011-01-01

    "Individual Learner Differences in SLA" addresses the apparently insoluble conflict between the unquestionably individual character of the process of second language acquisition/foreign language learning and the institutionalised, often inflexible character of formal instruction in which it takes place. How, then, is success in SLA so prevalent?

  9. Grading Exceptional and Struggling Learners

    ERIC Educational Resources Information Center

    Jung, Lee Ann; Guskey, Thomas R.

    2011-01-01

    How can you ensure that you are grading your exceptional students fairly? Teachers receive very little guidance for grading students with disabilities, English learners, and those receiving services through a response-to-intervention (RTI) process. This practitioner-friendly book provides teachers and administrators with an effective framework for…

  10. Are Deaf Students Visual Learners?

    ERIC Educational Resources Information Center

    Marschark, Marc; Morrison, Carolyn; Lukomski, Jennifer; Borgna, Georgianna; Convertino, Carol

    2013-01-01

    It is frequently assumed that by virtue of their hearing losses, deaf students are visual learners. Deaf individuals have some visual-spatial advantages relative to hearing individuals, but most have been linked to use of sign language rather than auditory deprivation. How such cognitive differences might affect academic performance has been…

  11. Learner Differences in Hint Processing

    ERIC Educational Resources Information Center

    Goldin, Ilya M.; Koedinger, Kenneth R.; Aleven, Vincent

    2012-01-01

    Although ITSs are supposed to adapt to differences among learners, so far, little attention has been paid to how they might adapt to differences in how students learn from help. When students study with an Intelligent Tutoring System, they may receive multiple types of help, but may not comprehend and make use of this help in the same way. To…

  12. English Language Learners: Annotated Bibliography

    ERIC Educational Resources Information Center

    Hector-Mason, Anestine; Bardack, Sarah

    2010-01-01

    This annotated bibliography represents a first step toward compiling a comprehensive overview of current research on issues related to English language learners (ELLs). It is intended to be a resource for researchers, policymakers, administrators, and educators who are engaged in efforts to bridge the divide between research, policy, and practice…

  13. Learner Diaries: Possibilities and Pitfalls.

    ERIC Educational Resources Information Center

    Howell-Richardson, Christina; Parkinson, Brian

    Learner diaries, or dialogue journals, are popular in second language teaching. Numerous teaching, learning, evaluative, and research-related uses for them have evolved. Pedagogically, they are used to identify and allay anxiety, offer advice on specific difficulties, provide study skill and individual feedback, encourage student self-assessment,…

  14. Distance Learners: Welcome to Campus!

    ERIC Educational Resources Information Center

    Schwitzer, Alan M.; Duggan, Mary H.

    2005-01-01

    Old Dominion University's distance learning program, called TELETECHNET, brings the main-campus college experience to geographically distant learners at sites across Virginia and as far away as the state of Washington, as well as to military personnel on Navy bases, carriers, and submarines. In an interesting turnabout, the Summer Institute for…

  15. for Teachers of English Learners

    ERIC Educational Resources Information Center

    Molle, Daniella

    2013-01-01

    For more than a decade, the professional development literature has shown that most teachers are not adequately prepared to teach English learners (ELs)--that holds true for both specialist and mainstream teachers (see, for example, August & Hakuta, 1997; Beykont, 2002). Research that focuses on professional development for teachers of ELs,…

  16. Reading and the Special Learner.

    ERIC Educational Resources Information Center

    Hedley, Carolyn N., Ed.; Hicks, John S., Ed.

    Compiled from papers presented at the annual Reading/Special Education Institute at Fordham University, this collection of essays addresses reading problems of special education students. The book is divided into three sections. The first section covers reading assessment and reading intervention; section 2 addresses the specific learner and the…

  17. Seven Things Adult Learners Dislike.

    ERIC Educational Resources Information Center

    Strzalka, Agnieszka

    1998-01-01

    A questionnaire was designed to elicit what adult learners disliked most about learning English. Seven dislikes were identified, including the following: textbooks in English only, role plays, drills, textbooks with no reading material or with artificial texts, homework, inflexible teachers, and audiotapes. (Author/VWL)

  18. Learners' Use of Learning Objects

    ERIC Educational Resources Information Center

    Ally, Mohamed; Cleveland-Innes, Martha; Boskic, Natasha; Larwill, Sandra

    2006-01-01

    This article reports findings from a study exploring the generativity (Gibbons, Nelson, & Richards, 2000; Parrish, 2004) and discoverability (Friesen, 2001) of learning objects in the hands of the learner. Through the convergence of two separate pilot projects--the Canadian EduSource initiative through Athabasca University, and the researchers'…

  19. Building a Community of Learners.

    ERIC Educational Resources Information Center

    New Leaders for Urban Schools, 1995

    1995-01-01

    The theme of this inaugural serial issue is "Building a Community of Learners." The serial has been designed to address school restructuring and reform and the roles of teachers, administrators, and parents. The first essay, "Constructing Communities of Cooperation" by Anne Turnbaugh Lockwood examines structural change in schools and what is meant…

  20. Building Resilience in Literacy Learners.

    ERIC Educational Resources Information Center

    Sanacore, Joseph

    Although an increasing number of young people encounter adversity in their environments, many manage to rebound and live successful lives while others repeat patterns of adversity in their adult lives. Classroom educators and special educators should therefore establish a learning environment that builds resilience in all learners. Educational…

  1. Teacher Investment in Learner Identity

    ERIC Educational Resources Information Center

    Reeves, Jenelle

    2009-01-01

    From a sociocultural perspective, teacher identity is constructed in relation to others, including other teachers and students. Drawing on positioning theory and the concept of investment, this study analyzed the case of a secondary English teacher who negotiated his teacher identity in relation to English language learners (ELLs). Findings…

  2. Learners in Action, Summer 2005

    ERIC Educational Resources Information Center

    Movement for Canadian Literacy, 2005

    2005-01-01

    This Summer 2005 issue of "Learners in Action" contains the following articles: (1) Bridging Barriers to Learning (Glenn Kissman); (2) Education Really Is a Family Affair; (3) Sabrina's Story; (4) SARAW Helps Students Find Their Voice; (5) Literacy Changes Lives; and (6) Seeing STARs in Alberta.

  3. Adult Learners' Week in Switzerland.

    ERIC Educational Resources Information Center

    Jermann, Ruth

    2002-01-01

    The slogan of International Adult Learners Week in Switzerland is "one hour a day for learning." Four goals of the lifelong learning agenda are government policies to promote access, public awareness campaigns, creation of public learning places, and development of networks for real and virtual learning. (SK)

  4. Developing Collections to Empower Learners

    ERIC Educational Resources Information Center

    Kimmel, Sue C.

    2014-01-01

    "Developing Collections to Empower Learners" examines collection development in the context of today's shifts toward digital resources while emphasizing the foundational beliefs of the school library profession. Writer Sue Kimmel includes practical advice about needs assessment, planning, selection, acquisitions, evaluation, and…

  5. Rich Environments for Adult Learners

    ERIC Educational Resources Information Center

    Bentham, Renee

    2008-01-01

    Unaware of the messages a bare adult learning environment sends and its effect on adult learners, a trainer attends an intensive Reggio Emilia course and learns that the physical environment is the "third teacher"--for adults as well as for children. Using principles of Reggio, she offers suggestions for enhancing adult learning spaces and…

  6. Confessions of a Language Learner.

    ERIC Educational Resources Information Center

    Moulton, William G.

    1974-01-01

    This Middlebury College summer 1974 commencement address is an informal presentation of the author's experiences as a language learner. The effectiveness of such pedagogical methods as the grammar-translation, audio-lingual, and "balanced" approaches, and of language learning with the aid of an informant, is discussed. It is concluded that, given…

  7. Teaching Reading to Struggling Learners

    ERIC Educational Resources Information Center

    Minskoff, Esther

    2005-01-01

    Identifying the best way to help students who struggle with reading--whether they have learning disabilities, are English language learners, or just need extra support--is a challenge for any teacher. Schools can make that task easier with this indispensable resource, a complete guide to addressing each student's specific instructional needs and…

  8. The Learner and the Computer.

    ERIC Educational Resources Information Center

    Ayers, George E.

    The revolution in computers begun in the mid 1950's will help education to meet the new challenges of the future generated by the predicted drastic declines in student enrollment and by changes in the types of learners served. Projects such as PLATO and TICCIT have proved that computers can provide useful and timely instruction for such learners…

  9. English Learners Program Guide. Revised

    ERIC Educational Resources Information Center

    Oregon Department of Education, 2013

    2013-01-01

    This guide is designed as a reference for District and School personnel working with English learners (ELs). The content of the guide represents a compilation of information, examples, and resources. This guide is a living document and subject to frequent updates. It is recommended to review the document online rather than printing a hard copy.

  10. More than a "Basic Skill": Breaking down the Complexities of Summarizing for ABE/ESL Learners

    ERIC Educational Resources Information Center

    Ouellette-Schramm, Jennifer

    2015-01-01

    This article describes the complex cognitive and linguistic challenges of summarizing expository text at vocabulary, syntactic, and rhetorical levels. It then outlines activities to help ABE/ESL learners develop corresponding skills.

  11. 48 CFR 52.222-20 - Walsh-Healey Public Contracts Act.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Act and regulations issued by the Secretary of Labor (41 CFR chapter 50) are incorporated by reference... (41 CFR 50-202.2). Learners, student learners, apprentices, and handicapped workers may be employed at less than the prescribed minimum wage (see 41 CFR 50-202.3) to the same extent that such employment...

  12. Beyond Classroom Discourse: Learning as Participation in Native Speaker-Learner and Learner-Learner Interactions

    ERIC Educational Resources Information Center

    Hoshi, Saori

    2015-01-01

    Consistent with the notion of learning as changing participation (Lave & Wenger, 1991; Rogoff, 1998; Sfard, 1998; Young & Miller, 2004), the present qualitative study investigated how social interaction between learners of Japanese as a foreign language and native speaker classroom guests contributed to the students' use of second language…

  13. Plurilingual Learners' Beliefs and Practices toward Native and Nonnative Language Mediation during Learner-Learner Interaction

    ERIC Educational Resources Information Center

    Payant, Caroline

    2015-01-01

    Due to the growing number of plurilingual learners in the world today (Hammarberg, 2010), the present multiple case study examines four plurilingual participants' beliefs toward first language (L1) and second language (L2) mediation in the acquisition of French as a third language (L3). During a 16-week classroom-based study in a French university…

  14. "Speech Act" Fra Teoria e Prassi Didattica. (The Speech Act between Theory and Pedagogical Practice).

    ERIC Educational Resources Information Center

    Minardi, Giovanni

    1982-01-01

    The author traces the development of speech act theory from Wittgenstein and Austin through Searle to Grice and shows how their work led to the notional functional approach to language teaching, which is based on the learner and his/her communicative needs. (CFM)

  15. Bovine papillomavirus type 1 DNA replication: the transcriptional activator E2 acts in vitro as a specificity factor.

    PubMed Central

    Bonne-Andréa, C; Tillier, F; McShan, G D; Wilson, V G; Clertant, P

    1997-01-01

    We previously devised cell-free conditions supporting efficient replication of bovine papillomavirus type 1 (BPV1) DNA (C. Bonne-Andréa, S. Santucci, and P. Clertant, J. Virol. 69:3201-3205, 1995): the use of highly active preparations of viral initiator protein E1, together with extract from a particular cell source, allowed the synthesis of complete DNA circles through successive rounds of replication; this occurred in the absence of the viral transcriptional activator E2, required in vivo for the replication of viral genomes. We now report that adding E2 to cell-free assays produced only slight effects both on the yield of E1-dependent DNA synthesis and on the quality of newly made DNA molecules when a template carrying a wild-type BPV1 replication origin (ori) was used. The performance of mouse cell extracts, unable to sustain efficient BPV1 DNA replication in the presence of E1 only, was likewise not improved by the addition of E2. In a proper in vitro environment, E1 is thus fully capable of efficiently initiating viral DNA synthesis by itself, an activity which is not enhanced by interaction with E2. An important effect, however, was detected: E2 totally suppressed the nonspecific replication of ori-defective DNA templates, otherwise observed in high E1 concentrations. We examined the requirements for building a minimal DNA sequence behaving in vitro as a specific ori sequence under stringent recognition conditions, i.e., in the presence of both E1 and E2. Only two elements, the 18-bp E1 binding palindrome and an AT-rich sequence, were required in cis to allow specific cell-free DNA replication; there seemed to be no need for an E2 binding site to ensure discrimination between specific ori templates and other DNA molecules, even in the presence of E2. This suggests that during the initiation of BPV1 DNA replication, at least in vitro, E2 acts as a specificity factor restricting the action of E1 to a defined ori sequence; this function, likely not demanding

  16. Career Education Activities Supported Under the Career Education Incentive Act (Public Law 95-207). Third Year's Program (Fiscal Year 1981 Funding).

    ERIC Educational Resources Information Center

    Office of Career Education (ED), Washington, DC.

    This report describes the fiscal year 1981 appropriations for implementing the third year of activities under the Career Education Incentive Act. Summarized first are three projects involving the demonstration and validation of a comprehensive elementary/secondary career project in a local setting (in the Ceres Unified School District in…

  17. The Impact of Four-Year Participation in Music and/or Athletic Activities in South Dakota Public High Schools on GPA and ACT Scores

    ERIC Educational Resources Information Center

    Jones, Patrick S.

    2010-01-01

    Finding the key to success for high school students has long been the goal for both school personnel and parents. This study examined the impact of four-year participation in music and/or athletics activities in South Dakota public high schools on student GPA and ACT scores. The data in this study were collected from five Class A high schools…

  18. Factors Associated with Implementation of the South Carolina Students Health and Fitness Act of 2005: Elementary School Principals' and Physical Activity Directors' Ratings

    ERIC Educational Resources Information Center

    Evans, Miriam Jones

    2012-01-01

    This study explores factors associated with implementation of the physical education and physical activity standards of the South Carolina Students Health and Fitness Act of 2005 in Title I elementary schools. The study was framed using selected components of the diffusion of innovations theory, which looked at characteristics of the law and their…

  19. Chlamydia screening for sexually active young women under the Affordable Care Act: new opportunities and lingering barriers.

    PubMed

    Loosier, Penny S; Malcarney, Mary-Beth; Slive, Lauren; Cramer, Ryan C; Burgess, Brittany; Hoover, Karen W; Romaguera, Raul

    2014-09-01

    The Affordable Care Act of 2010 (ACA) contains a provision requiring private insurers issuing or renewing plans on or after September 23, 2010, to provide, without cost sharing, preventive services recommended by US Preventive Services Task Force (grades A and B), among other recommending bodies. As a grade A recommendation, chlamydia screening for sexually active young women 24 years and younger and older women at risk for chlamydia falls under this requirement. This article examines the potential effect on chlamydia screening among this population across private and public health plans and identifies lingering barriers not addressed by this legislation. Examination of the impact on women with private insurance touches upon the distinction between coverage under grandfathered plans, where the requirement does not apply, and nongrandfathered plans, where the requirement does apply. Acquisition of private health insurance through health insurance Marketplaces is also discussed. For public health plans, coverage of preventive services without cost sharing differs for individuals enrolled in standard Medicaid, covered under the Medicaid expansion included in the ACA, or those enrolled under the Children's Health Insurance Program or who fall under Early, Periodic, Screening, Diagnosis and Treatment criteria. The discussion of lingering barriers not addressed by the ACA includes the uninsured, physician reimbursement, cost sharing, confidentiality, low rates of appropriate sexual history taking by providers, and disclosures of sensitive information. In addition, the role of safety net programs that provide health care to individuals regardless of ability to pay is examined in light of the expectation that they also remain a payer of last resort. PMID:25118966

  20. Performance test results of noninvasive characterization of Resource Conservation and Recovery Act surrogate waste by prompt gamma neutron activation analysis

    SciTech Connect

    Gehrke, R.J.; Streier, G.G.

    1997-03-01

    During FY-96, a performance test was carried out with funding from the Mixed Waste Focus Area (MWFA) of the Department of Energy (DOE) to determine the noninvasive elemental assay capabilities of commercial companies for Resource Conservation and Recovery Act (RCRA) metals present in 8-gal drums containing surrogate waste. Commercial companies were required to be experienced in the use of prompt gamma neutron activation analysis (PGNAA) techniques and to have a prototype assay system with which to conduct the test assays. Potential participants were identified through responses to a call for proposals advertised in the Commerce Business Daily and through personal contacts. Six companies were originally identified. Two of these six were willing and able to participate in the performance test, as described in the test plan, with some subsidizing from the DOE MWFA. The tests were conducted with surrogate sludge waste because (1) a large volume of this type of waste awaits final disposition and (2) sludge tends to be somewhat homogeneous. The surrogate concentrations of the above RCRA metals ranged from {approximately} 300 ppm to {approximately} 20,000 ppm. The lower limit was chosen as an estimate of the expected sensitivity of detection required by noninvasive, pretreatment elemental assay systems to be of value for operational and compliance purposes and to still be achievable with state-of-the-art methods of analysis. The upper limit of {approximately} 20,000 ppm was chosen because it is the opinion of the author that assay above this concentration level is within current state-of-the-art methods for most RCRA constituents. This report is organized into three parts: Part 1, Test Plan to Evaluate the Technical Status of Noninvasive Elemental Assay Techniques for Hazardous Waste; Part 2, Participants` Results; and Part 3, Evaluation of and Comments on Participants` Results.

  1. Interleukin-17A Acts to Maintain Neuropathic Pain Through Activation of CaMKII/CREB Signaling in Spinal Neurons.

    PubMed

    Yao, Cheng-Ye; Weng, Ze-Lin; Zhang, Jian-Cheng; Feng, Tao; Lin, Yun; Yao, Shanglong

    2016-08-01

    Immunity and neuroinflammation play major roles in neuropathic pain. Spinal interleukin (IL)-17A, as a mediator connecting innate and adaptive immunity, has been shown to be an important cytokine in neuroinflammation and acute neuropathic pain. However, the effects and underlying mechanisms of spinal IL-17A in the maintenance of neuropathic pain remain unknown. This study was designed to investigate whether spinal IL-17A acted to maintain neuropathic pain and to elucidate the underlying mechanisms in IL-17A knockout or wild-type (WT) mice following L4 spinal nerve ligation (L4 SNL). WT mice were treated with anti-IL-17A neutralized monoclonal antibody (mAb) or recombinant IL-17A (rIL-17A). We showed that IL-17A levels were significantly increased 1, 3, 7, and 14 days after SNL in spinal cord. Double immunofluorescence staining showed that astrocytes were the major cellular source of spinal IL-17A. IL-17A knockout or anti-IL-17A mAb treatment significantly ameliorated hyperalgesia 7 days after SNL, which was associated with a significant reduction of p-CaMKII and p-CREB levels in spinal cord, whereas rIL-17A treatment conferred the opposite effects. Furthermore, we showed that blocking CaMKII with KN93 significantly reduced SNL- or rIL-17A-induced hyperalgesia and p-CREB expression. Our in vitro data showed that KN93 also significantly inhibited rIL-17A-induced CREB activation in primary cultured spinal neurons. Taken together, our study indicates that astrocytic IL-17A plays important roles in the maintenance of neuropathic pain through CaMKII/CREB signaling pathway in spinal cord, and thus targeting IL-17A may offer an attractive strategy for the treatment of chronic persistent neuropathic pain. PMID:26166359

  2. The redox-active drug metronidazole and thiol-depleting garlic compounds act synergistically in the protist parasite Spironucleus vortens.

    PubMed

    Williams, C F; Vacca, A R; Dunham, L; Lloyd, D; Coogan, M P; Evans, G; Graz, M; Cable, J

    2016-01-01

    Spironucleus vortens is a protozoan parasite associated with significant mortalities in the freshwater angelfish, Pterophyllum scalare. Control of this parasite is especially problematic due to restrictions on the use of the drug of choice, metronidazole (MTZ), on fish farms. Use of garlic (Allium sativum) is undergoing a renaissance following experimental validations of its antimicrobial efficiency. Ajoene ((E,Z)-4,5,9-trithiadodeca-1,6,11-triene 9-oxide), is a stable transformation product of allicin, the primary biologically active component of garlic. In the current study, an ajoene oil crude extract had a minimum inhibitory concentration (MIC) of 40μg/ml against S. vortens. GC-MS and NMR spectroscopy revealed this ajoene extract contained a mixture of the (E) and (Z)-ajoene isomers along with diallyl disulphide (DADS) and diallyl trisulphide (DATS). The only component of the ajoene crude oil found to substantially inhibit S. vortens growth by optical density monitoring (Bioscreen C Reader) was (Z)-ajoene (MIC 16μg/ml). Ajoene oil acted in synergy with MTZ in vitro, reducing the individual MIC of this drug (4μg/ml) by 16-fold, and that of ajoene oil by 200-fold with a fractional inhibitory concentration (FIC) index of 0.263. This synergistic interaction was confirmed in vivo. S. vortens-infected Pterophyllum scalare angelfish dosed orally with 0.5% (v/w) MTZ combined with 0.05% (v/w) ajoene displayed a significant reduction in faecal trophozoite count, whilst those fed on 0.5% MTZ flakes (half the recommended oral dose) alone did not. This study demonstrates for the first time the synergistic interaction between the synthetic drug MTZ and natural ajoene oil both in vitro and in vivo. Future work should evaluate the potential synergy of ajoene and MTZ against MTZ-resistant bacteria and protists. PMID:26968264

  3. The Role of Private Speech in Cognitive Regulation of Learners: The Case of English as a Foreign Language Education

    ERIC Educational Resources Information Center

    Sarab, Mohamad Reza Anani; Gordani, Yahya

    2015-01-01

    Investigations into the use of private speech by adult English foreign language (EFL) learners in regulating their mental activities have been an interesting area of research with a sociocultural framework. Following this line of research, 30 advanced adult EFL learners were selected via the administration of Oxford quick placement test and took a…

  4. Digging Deeper into Learners' Experiences in MOOCs: Participation in Social Networks outside of MOOCs, Notetaking and Contexts Surrounding Content Consumption

    ERIC Educational Resources Information Center

    Veletsianos, George; Collier, Amy; Schneider, Emily

    2015-01-01

    Researchers describe with increasing confidence "what" they observe participants doing in massive open online courses (MOOCs). However, our understanding of learner activities in open courses is limited by researchers' extensive dependence on log file analyses and clickstream data to make inferences about learner behaviors. Further, the…

  5. More Evidence Concerning the Aspect Hypothesis: The Acquisition of English Progressive Aspect by Catalan-Spanish Instructed Learners

    ERIC Educational Resources Information Center

    Munoz, Carmen; Gilabert, Roger

    2011-01-01

    A robust finding from studies investigating the Aspect Hypothesis is that learners at the early stages of acquisition show a strong preference for using the progressive aspect as associated with activity verbs. As they advance in their acquisition of the second or foreign language, learners move from this prototypical association to associations…

  6. The Wonder of Reading: The Effect of Generative Study Strategies on EFL Learners' Reading Comprehension and Recall of Short Stories

    ERIC Educational Resources Information Center

    Ghazanfari, Mohammad; Sarani, Abdullah

    2009-01-01

    EFL learners often tend to shift the major load of language learning task to the reading skill, due to insufficient access to the spoken mode of language. Experiences of practitioners as well as various research reports in the literature indicate that the more actively learners get engaged with the reading materials, the more profound their…

  7. Learning at a Distance through Mobile Devices: A Global Choice of Learners in the Open and Distance Learning (ODL) System

    ERIC Educational Resources Information Center

    Sethy, Satya

    2011-01-01

    In the techno-driven world, mobile learning is an indispensable element of teaching-learning activities. It helps distance learners in many ways by providing their required facilities. The paper discusses about these facilities in an eclectic and summary manner. Thus, by implication, it is popularized among distance learners across the globe.…

  8. Programs for English Language Learners: Resource Materials for Planning and Self-Assessments.

    ERIC Educational Resources Information Center

    Office for Civil Rights (ED), Washington, DC.

    These resource materials were developed in response to requests from school districts for a reference tool to assist them through the process of developing a comprehensive English language learners (ELL) program. The districts desired a program that would be in compliance with Title VI of the Civil Rights Act of 1964. Title VI was passed in the…

  9. Engaging Native American Learners with Rigor "and" Cultural Relevance. Issue Brief

    ERIC Educational Resources Information Center

    Oakes, Abner; Maday, Traci

    2009-01-01

    Currently, the federal government administers several programs that aim to address the "unique educational and culturally related academic needs" (Title VII, Part A, Elementary and Secondary Education Act, 2002) of Native American students. What does this mean for today's teachers and learners? Unfortunately, the drive to significantly raise…

  10. Equitable Access for Secondary English Learner Students: Course Taking as Evidence of EL Program Effectiveness

    ERIC Educational Resources Information Center

    Callahan, Rebecca M.; Shifrer, Dara

    2016-01-01

    Purpose: English learner (EL) education policy has long directed schools to address EL students' linguistic "and" academic development without furthering inequity or segregation. The recent Every Student Succeeds Act reauthorization expresses a renewed focus on evidence of equity, effectiveness, and opportunity to learn. We propose that…

  11. Providing Services for Learners with Severe Disabilities: A Workbook for Developing Communication.

    ERIC Educational Resources Information Center

    Stremel, Kathleen; Wilson, Rebecca

    This workbook for developing communication in learners with severe disabilities is from the Mississippi Early Education Program for Children with Multiple Disabilities, a program designed to train Individuals with Disabilities Education Act Part H service coordinators and service providers to use family centered strategies. The objective of the…

  12. Descriptive Study of State Assessment Policies for Accommodating English Language Learners

    ERIC Educational Resources Information Center

    Willner, Lynn Shafer; Rivera, Charlene; Acosta, Barbara D.

    2008-01-01

    In 2006, the Government Accountability Office (GAO) conducted a study of the U.S. Department of Education's (ED)'s efforts to support states in meeting the No Child Left Behind Act (NCLB) (Ashby, 2006). The study found the requirement to include all students, including English language learners (ELLs) in standards and assessment systems, a…

  13. State Education Policy Formation: The Case of Arizona's English Language Learner Legislation

    ERIC Educational Resources Information Center

    Lawton, Stephen B.

    2012-01-01

    This historical case study focuses on policy making at the state level by analyzing the development of a new policy for English language learners (ELLs) in Arizona. "New institutionalism" is used as a framework, with political culture and educational regimes acting as environmental factors affecting state policy choices. Key events occurred…

  14. 29 CFR 516.30 - Learners, apprentices, messengers, students, or handicapped workers employed under special...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Learners, apprentices, messengers, students, or handicapped... handicapped workers employed under special certificates as provided in section 14 of the Act. (a) With respect... education, or handicapped workers employed at special minimum hourly rates under Special...

  15. Assessment of English Language Learners in the Era of New Academic Content Standards

    ERIC Educational Resources Information Center

    Bailey, Alison L.; Carroll, Patricia E.

    2015-01-01

    The purpose of this chapter is twofold: (1) to provide a detailed review of current language assessment policies and practices with English language learner (ELL) students under the federal requirements of the No Child Left Behind Act (NCLB; 2001) and relevant research in order to evaluate their technical quality and validity, and (2) to examine…

  16. Test Accommodations for English Language Learners Using the Student Language Assessment Plan

    ERIC Educational Resources Information Center

    Brantley, Sherri G.

    2014-01-01

    Public schools are attempting to work with a growing number of immigrant English language learners (ELLs) in the U.S. education system at a time when the No Child Left Behind (NCLB) Act has mandated that ELLs achieve proficiency on assessments even if they have not acquired sufficient language proficiency. The purpose of this qualitative case…

  17. 29 CFR 516.30 - Learners, apprentices, messengers, students, or handicapped workers employed under special...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 3 2013-07-01 2013-07-01 false Learners, apprentices, messengers, students, or handicapped workers employed under special certificates as provided in section 14 of the Act. 516.30 Section 516.30 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS RECORDS TO BE KEPT BY EMPLOYERS...

  18. 29 CFR 516.30 - Learners, apprentices, messengers, students, or handicapped workers employed under special...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 3 2014-07-01 2014-07-01 false Learners, apprentices, messengers, students, or handicapped workers employed under special certificates as provided in section 14 of the Act. 516.30 Section 516.30 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS RECORDS TO BE KEPT BY EMPLOYERS...

  19. The Impact of High-Stakes Accountability Policies on Native American Learners: Evidence from Research

    ERIC Educational Resources Information Center

    McCarty, Teresa L.

    2009-01-01

    This article examines research on the impacts of high-stakes accountability policies in the USA--in particular, the No Child Left Behind (NCLB) Act of 2001--on Native American learners. NCLB's goals are laudable: close the achievement gap by making schools accountable for learning among all student groups, and by ensuring that all students are…

  20. Rater Behaviour When Judging Language Learners' Pragmatic Appropriateness in Extended Discourse

    ERIC Educational Resources Information Center

    Sydorenko, Tetyana; Maynard, Carson; Guntly, Erin

    2014-01-01

    The criteria by which raters judge pragmatic appropriateness of language learners' speech acts are underexamined, especially when raters evaluate extended discourse. To shed more light on this process, the present study investigated what factors are salient to raters when scoring pragmatic appropriateness of extended request sequences, and which…

  1. The Learners of the 1980s: Windex for the University Administrator's Crystal Ball.

    ERIC Educational Resources Information Center

    Fretwell, E. K., Jr.

    1980-01-01

    Higher education in the 1980s is addressed with a focus on two major questions: (1) Who are the learners likely to be? and (2) How can the higher educational community act and react in positive and future-oriented ways? Possible changes in enrollment and student characteristics, and some alternatives to the traditional educational system are…

  2. "No Child" Effect on English-Learners Mulled: Teachers Welcome Attention, Fault Focus on Test Scores

    ERIC Educational Resources Information Center

    Zehr, Mary Ann

    2006-01-01

    Educators who specialize in teaching English-language learners agree that the 4-year-old No Child Left Behind Act has brought unprecedented attention to those students by requiring schools to isolate test-score data for them. They disagree, though, on whether changes in instruction spurred by the law have been positive or negative overall. Such…

  3. High-Stakes Math Tests: How "No Child Left Behind" Leaves Newcomer English Language Learners behind

    ERIC Educational Resources Information Center

    Wright, Wayne E.; Li, Xiaoshi

    2008-01-01

    The "No Child Left Behind Act" establishes federal education policy for the United States, with a heavy focus on accountability through high-stakes testing. Provisions specific to English language learners (ELLs) include the mandate for their inclusion in state math tests, even for newcomer students enrolled for less than one year. Most ELLs take…

  4. Teaching English Language Learners in Mainstream Science Classrooms: Teacher Practice and Educational Opportunity

    ERIC Educational Resources Information Center

    Schroeder, Carlotta Dorothy

    2011-01-01

    Equal educational opportunity for English language learners (ELLs) has been a goal of the public educational system in the United States. Language policy reforms have increased accountability in order for schools to improve student achievement and measure the progress of ELLs. The No Child Left Behind Act (NCLB) requires assessment and…

  5. Are Deaf Students Visual Learners?

    PubMed

    Marschark, Marc; Morrison, Carolyn; Lukomski, Jennifer; Borgna, Georgianna; Convertino, Carol

    2013-06-01

    It is frequently assumed that by virtue of their hearing losses, deaf students are visual learners. Deaf individuals have some visual-spatial advantages relative to hearing individuals, but most have been are linked to use of sign language rather than auditory deprivation. How such cognitive differences might affect academic performance has been investigated only rarely. This study examined relations among deaf college students' language and visual-spatial abilities, mathematics problem solving, and hearing thresholds. Results extended some previous findings and clarified others. Contrary to what might be expected, hearing students exhibited visual-spatial skills equal to or better than deaf students. Scores on a Spatial Relations task were associated with better mathematics problem solving. Relations among the several variables, however, suggested that deaf students are no more likely to be visual learners than hearing students and that their visual-spatial skill may be related more to their hearing than to sign language skills. PMID:23750095

  6. Symphony: A case study for exploring and describing design methods and guidelines for learner-centered design

    NASA Astrophysics Data System (ADS)

    Quintana, Christopher

    Learner-centered design is an evolving software design perspective addressing the needs of learners---a specific audience trying to work in and understand new work practices in which they have a novice or naive understanding. Learner-centered design involves designing software that incorporates work support features (or scaffolding features) informed by social constructivist learning theories. By adopting a constructivist "learning by doing" perspective, scaffolds should support learners so they can mindfully engage in previously inaccessible work activity, which in turn allows those learners to progressively gain a better understanding of the new work. While there is an intuitive notion of "learner-centered design", there is less specific design information for developing learner-centered software. As a result, learner-centered software results from "educated guesses" and ad-hoc design approaches rather than from systematic design methods. Thus there is a need for specific design guidance to facilitate the development of learner-centered tools that help learners see the tasks, terminology, tools, etc. in the new work context and engage in that work. The research in this dissertation provides a more specific base of learner-centered design descriptions, methods, and guidelines to analyze work practices and design and evaluate scaffolds. The research approach involves using the development of Symphony---a scaffolded integrated tool environment for high-school students learning the work of computational science inquiry---as a case study to develop the learner-centered design approach. Symphony incorporates a variety of science tools with process scaffolding to support students in performing complex air pollution investigations. Six ninth-grade students used Symphony to investigate air quality questions for several weeks in an environmental science class. The student testing helped assess the effectiveness of the software scaffolding and in turn, the learner

  7. Modeling the effects of multicontextual physics instruction on learner expectations and understanding of force and motion systems

    NASA Astrophysics Data System (ADS)

    Deese Becht, Sara-Maria Francis

    1999-11-01

    The purpose of this study is two-fold involving both practical and theoretical modeling components. The practical component, an experiential-learning phase, investigated a study population for effects that increasing levels of multicontextual physics activities have on student understanding of Newtonian systems of motion. This contextual-learning model measured learner convictions and non-response gaps and analyzed learner response trends on context, technology, challenge, growth, and success. The theoretical component, a model-building phase, designed a dynamic-knowing model for learning along a range of experiential tasks, from low to high context, monitored for indicators of learning in science and mathematics: learner academic performance and ability, learner control and academic attitude, and a learner non- response gap. This knowing model characterized a learner's process-of-knowing on a less to more expert- like learner-response continuum using performance and perspective indices associated with level of contextual- imagery referent system. Data for the contextual-learning model were collected on 180 secondary subjects: 72 middle and 108 high, with 36 physics subjects as local experts. Subjects were randomly assigned to one of three experimental groups differing only on context level of force and motion activities. Three levels of information were presented through context-based tasks: momentum constancy as inertia, momentum change as impulse, and momentum rate of change as force. The statistical analysis used a multi-level factorial design with repeated measures and discriminate analysis of response-conviction items. Subject grouping criteria included school level, ability level in science and mathematics, gender and race. Assessment criteria used pre/post performance scores, confidence level in physics concepts held, and attitude towards science, mathematics, and technology. Learner indices were computed from logit- transforms applied to learner outcomes

  8. Learners and Learning.

    ERIC Educational Resources Information Center

    Grant, Frank

    2002-01-01

    Behavioral, humanistic, cognitive, constructivist, and neuroscience theories of learning are briefly described. In the training of outdoor activity instructors/teachers, the curriculum should contain modules on various learning styles so that participants have equal opportunities to digest outdoor experiences and interpret them in a manner that…

  9. First-in-humans study of the safety, tolerability, and pharmacokinetics of ACT-451840, a new chemical entity with antimalarial activity.

    PubMed

    Bruderer, Shirin; Hurst, Noémie; de Kanter, Ruben; Miraval, Tommaso; Pfeifer, Thomas; Donazzolo, Yves; Dingemanse, Jasper

    2015-02-01

    Emerging resistance to antimalarial agents raises the need for new drugs. ACT-451840 is a new compound with potent activity against sensitive and resistant Plasmodium falciparum strains. This was a first-in-humans single-ascending-dose study to investigate the safety, tolerability, and pharmacokinetics of ACT-451840 across doses of 10, 50, 200, and 500 mg in healthy male subjects. In the 200- and 500-mg dose groups, the effect of food was investigated, and antimalarial activity was assessed using an ex vivo bioassay with P. falciparum. No (serious) adverse events leading to discontinuation were reported. At the highest dose level, the peak drug concentration (Cmax) and the area under the plasma concentration-time curve from zero to infinity of ACT-451840 under fasted conditions reached 11.9 ng/ml and 100.6 ng·h/ml, respectively, and these were approximately 13-fold higher under fed conditions. Food did not affect the half-life (approximately 34 h) of the drug, while the Cmax was attained 2.0 and 3.5 h postdose under fasted and fed conditions, respectively. The plasma concentrations estimated by the bioassay were approximately 4-fold higher than those measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Several potentially active metabolites were also identified. ACT-451840 was well tolerated across all doses. Exposure to ACT-451840 significantly increased with food. The bioassay indicated the presence of circulating active metabolites. (This study has been registered at ClinicalTrials.gov under registration no. NCT02186002.). PMID:25421475

  10. First-in-Humans Study of the Safety, Tolerability, and Pharmacokinetics of ACT-451840, a New Chemical Entity with Antimalarial Activity

    PubMed Central

    Bruderer, Shirin; Hurst, Noémie; de Kanter, Ruben; Miraval, Tommaso; Pfeifer, Thomas; Donazzolo, Yves

    2014-01-01

    Emerging resistance to antimalarial agents raises the need for new drugs. ACT-451840 is a new compound with potent activity against sensitive and resistant Plasmodium falciparum strains. This was a first-in-humans single-ascending-dose study to investigate the safety, tolerability, and pharmacokinetics of ACT-451840 across doses of 10, 50, 200, and 500 mg in healthy male subjects. In the 200- and 500-mg dose groups, the effect of food was investigated, and antimalarial activity was assessed using an ex vivo bioassay with P. falciparum. No (serious) adverse events leading to discontinuation were reported. At the highest dose level, the peak drug concentration (Cmax) and the area under the plasma concentration-time curve from zero to infinity of ACT-451840 under fasted conditions reached 11.9 ng/ml and 100.6 ng · h/ml, respectively, and these were approximately 13-fold higher under fed conditions. Food did not affect the half-life (approximately 34 h) of the drug, while the Cmax was attained 2.0 and 3.5 h postdose under fasted and fed conditions, respectively. The plasma concentrations estimated by the bioassay were approximately 4-fold higher than those measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Several potentially active metabolites were also identified. ACT-451840 was well tolerated across all doses. Exposure to ACT-451840 significantly increased with food. The bioassay indicated the presence of circulating active metabolites. (This study has been registered at ClinicalTrials.gov under registration no. NCT02186002.) PMID:25421475

  11. Learning Science Using AR Book: A Preliminary Study on Visual Needs of Deaf Learners

    NASA Astrophysics Data System (ADS)

    Megat Mohd. Zainuddin, Norziha; Badioze Zaman, Halimah; Ahmad, Azlina

    Augmented Reality (AR) is a technology that is projected to have more significant role in teaching and learning, particularly in visualising abstract concepts in the learning process. AR is a technology is based on visually oriented technique. Thus, it is suitable for deaf learners since they are generally classified as visual learners. Realising the importance of visual learning style for deaf learners in learning Science, this paper reports on a preliminary study of on an ongoing research on problems faced by deaf learners in learning the topic on Microorganisms. Being visual learners, they have problems with current text books that are more text-based that graphic based. In this preliminary study, a qualitative approach using the ethnographic observational technique was used so that interaction with three deaf learners who are participants throughout this study (they are also involved actively in the design and development of the AR Book). An interview with their teacher and doctor were also conducted to identify their learning and medical problems respectively. Preliminary findings have confirmed the need to design and develop a special Augmented Reality Book called AR-Science for Deaf Learners (AR-SiD).

  12. Recasts, Metalinguistic Feedback, and Learners' Perceptions: A Case of Persian EFL Learners

    ERIC Educational Resources Information Center

    Rassaei, Ehsan; Moinzadeh, Ahmad

    2014-01-01

    In the current study, we present the results of an experiment with 30 Persian EFL learners in which we explored the learners' perceptions of recasts and metalinguistic corrective feedback. The participant learners received either recasts or metalinguistic feedback for their errors during task-based interactions with their interlocutors and then…

  13. The Attitudes of Field Dependence Learners for Learner Interface Design (LID) in e-Learning Instruction

    ERIC Educational Resources Information Center

    Sözcü, Ömer Faruk; Ipek, Ismail; Kinay, Hüseyin

    2016-01-01

    The purpose of the study is to explore relationships between learners' cognitive styles of field dependence and learner variables in the preference of learner Interface design, attitudes in e-Learning instruction and experience with e-Learning in distance education. Cognitive style has historically referred to a psychological dimension…

  14. Promoting Learner Engagement when Working with Adult English Language Learners. CAELA Network Brief

    ERIC Educational Resources Information Center

    Miller, Susan Finn

    2010-01-01

    Teachers of adults learning English often compete with many demands on learners' attention. Concerns about family, jobs, money, and transportation; fatigue; and negative past experiences with education are some of the factors that might inhibit an adult learner's full engagement in class. In a study of learner engagement in adult literacy…

  15. Strategy-Based Instruction: A Learner-Focused Approach to Developing Learner Autonomy

    ERIC Educational Resources Information Center

    Nguyen, Le Thi Cam; Gu, Yongqi

    2013-01-01

    This study investigates the effects of strategy-based instruction (SBI) on the promotion of learner autonomy (LA). LA was conceptualized and operationally defined as learner self-initiation and learner self-regulation. An intervention study was conducted with the participation of 37 students in an experimental group, and 54 students in two control…

  16. Learner Agency in Language Learning: The Story of a Distance Learner of EFL in China

    ERIC Educational Resources Information Center

    Xiao, Junhong

    2014-01-01

    Learner agency plays a key role in self-regulated learning. Yet, there is a paucity of research into its role in the distance learning context. Using reflective narratives written by a distance learner of English in China, this longitudinal case study aims to investigate the ways in which learner agency mediates the language learning in the…

  17. Learner-Generated Noticing of Written L2 Input: What Do Learners Notice and Why?

    ERIC Educational Resources Information Center

    Park, Eun Sung

    2011-01-01

    This study explored learners' self-generated noticing of L2 input. It is motivated by previous research on input enhancement which suggested that learners are able to notice certain aspects of input on their own without any external means to direct their attention. Drawing on insights that learner-generated noticing is largely mediated by…

  18. Providing Effective Learner Support for Part-Time Learners. Research Report

    ERIC Educational Resources Information Center

    Barker, Philip; Crawley, Jim

    2005-01-01

    Learner support, defined as the strategies which empower learners to establish and fulfill their learning, career and personal potential, continues to be a key issue in current thinking in the post-16 education sector. An earlier project report from the West Country Learning and Skills Research Network (WCLSRN) showed that part-time learners were…

  19. Re-Awakening the Learner: Creating Learner-Centric, Standards-Driven Schools

    ERIC Educational Resources Information Center

    Stoll, Copper; Giddings, Gene

    2012-01-01

    Transformation of public education requires the reawakening of the sleeping giant in the room: the learners. Students, teachers, and principals must develop a learner-centric, standards-driven school. "Reawakening the Learner" is a guide to creating just such an environment. Continua describe the journey of teachers, teacher leaders, and…

  20. Using Response to Intervention to Support Struggling Learners

    ERIC Educational Resources Information Center

    Lose, Mary K.

    2008-01-01

    By rejecting the term "slow learner" and using evidence-based response-to-intervention approaches, principals can effectively help struggling learners. This article includes six action steps principals can take immediately to support these learners.

  1. Phylogenetic variation in glycosidases and glycanases acting on plant cell wall polysaccharides, and the detection of transglycosidase and trans-β-xylanase activities.

    PubMed

    Franková, Lenka; Fry, Stephen C

    2011-08-01

    Wall polysaccharide chemistry varies phylogenetically, suggesting a need for variation in wall enzymes. Although plants possess the genes for numerous putative enzymes acting on wall carbohydrates, the activities of the encoded proteins often remain conjectural. To explore phylogenetic differences in demonstrable enzyme activities, we extracted proteins from 57 rapidly growing plant organs with three extractants, and assayed their ability to act on six oligosaccharides 'modelling' selected cell-wall polysaccharides. Based on reaction products, we successfully distinguished exo- and endo-hydrolases and found high taxonomic variation in all hydrolases screened: β-D-xylosidase, endo-(1→4)-β-D-xylanase, β-D-mannosidase, endo-(1→4)-β-D-mannanase, α-D-xylosidase, β-D-galactosidase, α-L-arabinosidase and α-L-fucosidase. The results, as GHATAbase, a searchable compendium in Excel format, also provide a compilation for selecting rich sources of enzymes acting on wall carbohydrates. Four of the hydrolases were accompanied, sometimes exceeded, by transglycosylase activities, generating products larger than the substrate. For example, during β-xylosidase assays on (1→4)-β-D-xylohexaose (Xyl₆), Marchantia, Selaginella and Equisetum extracts gave negligible free xylose but approximately equimolar Xyl₅ and Xyl₇, indicating trans-β-xylosidase activity, also found in onion, cereals, legumes and rape. The yield of Xyl₉ often exceeded that of Xyl₇₋₈, indicating that β-xylanase was accompanied by an endotransglycosylase activity, here called trans-β-xylanase, catalysing the reaction 2Xyl₆ → Xyl₃ + Xyl₉. Similar evidence also revealed trans-α-xylosidase, trans-α-arabinosidase and trans-α-arabinanase activities acting on xyloglucan oligosaccharides and (1→5)-α-L-arabino-oligosaccharides. In conclusion, diverse plants differ dramatically in extractable enzymes acting on wall carbohydrate, reflecting differences in wall polysaccharide

  2. Integrated Application of Active Controls (IAAC) technology to an advanced subsonic transport project: Current and advanced act control system definition study, volume 1

    NASA Technical Reports Server (NTRS)

    Hanks, G. W.; Shomber, H. A.; Dethman, H. A.; Gratzer, L. B.; Maeshiro, A.; Gangsaas, D.; Blight, J. D.; Buchan, S. M.; Crumb, C. B.; Dorwart, R. J.

    1981-01-01

    An active controls technology (ACT) system architecture was selected based on current technology system elements and optimal control theory was evaluated for use in analyzing and synthesizing ACT multiple control laws. The system selected employs three redundant computers to implement all of the ACT functions, four redundant smaller computers to implement the crucial pitch-augmented stability function, and a separate maintenance and display computer. The reliability objective of probability of crucial function failure of less than 1 x 10 to the -9th power per flight of 1 hr can be met with current technology system components, if the software is assumed fault free and coverage approaching 1.0 can be provided. The optimal control theory approach to ACT control law synthesis yielded comparable control law performance much more systematically and directly than the classical s-domain approach. The ACT control law performance, although somewhat degraded by the inclusion of representative nonlinearities, remained quite effective. Certain high-frequency gust-load alleviation functions may require increased surface rate capability.

  3. Exploring Lifelong Learners Engaged in an Astronomy-Related Massively Open Online Course

    NASA Astrophysics Data System (ADS)

    Buxner, Sanlyn; Impey, Chris David; Wenger, Matthew; Formanek, Martin; Romine, James M.

    2016-01-01

    Massively open online courses (MOOCs) are becoming increasingly popular ways to reach diverse lifelong learners all over the world. Although MOOCs resemble more formal classes (e.g. videos of content, quizzes, activities), they are often used by informal audiences from home. Recently, MOOCs have become more utilized by universities to conduct outreach as they explore how to use MOOCs to reach new potential learners. Despite the rapid adaption of MOOCs, little is known about individuals who choose to take a MOOC, how they interact with the course materials, and what motivates them to finish the course.We present results of a study of lifelong learners engaged in an astronomy "101" MOOC. Through analysis of registered learners' behaviors as well as self-reported responses to a survey about science, we were able to characterize a subset of the learners engaged in the MOOC during its first offering. Overall, 25363 learners from over 100 countries registered for the MOOC. Of those, 14900 accessed at least one part of the course. Learners were recruited to complete a survey of their knowledge and attitudes towards science. Of the learner group who opened the course, 2889 individuals completed the survey, 2465 of those were able to be linked to their usage of the MOOC through a unique identifier.Learners represented a wide-range of ages, professions, and previous science experience. The best predictors for MOOC completion were engagement in the first activity and first writing assignment and engagement in the online forum. Learners were very interested in science prior to their registration, had higher basic science knowledge that most undergraduate students enrolled in a parallel astronomy course, and used online searches and science sites to get their information about science. As we reach out to a worldwide audience to learners in these massively open online courses, understanding their motivations and behaviors will be essential. This work is helping us understand and

  4. Learner Satisfaction in Online Learning: An Analysis of the Perceived Impact of Learner-Social Media and Learner-Instructor Interaction

    ERIC Educational Resources Information Center

    Andersen, Jeffery C.

    2013-01-01

    The purpose of this study was to determine the relationships between general course satisfaction, learner-instructor interaction, and the learner-social media interaction scores of participants. This study used an online survey with 60 questions to gather the participants' demographic data, learner-instructor interaction data, learner-social…

  5. The Effects of Direct and Indirect Speech Acts on Native English and ESL Speakers' Perception of Teacher Written Feedback

    ERIC Educational Resources Information Center

    Baker, Wendy; Hansen Bricker, Rachel

    2010-01-01

    This study explores how second language (L2) learners perceive indirect (hedging or indirect speech acts) and direct written teacher feedback. Though research suggests that indirect speech acts may be more difficult to interpret than direct speech acts ([Champagne, 2001] and [Holtgraves, 1999]), using indirect speech acts is often encouraged in…

  6. 33 CFR 128.220 - What must I do to report an unlawful act and related activity?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Federal Bureau of Investigation (FBI), and to the local police agency having jurisdiction over the..., DEPARTMENT OF HOMELAND SECURITY (CONTINUED) WATERFRONT FACILITIES SECURITY OF PASSENGER TERMINALS Security... terminal security officer must report each breach of security, unlawful act, or threat of an unlawful...

  7. Learner-Generated Noticing Behavior by Novice Learners: Tracing the Effects of Learners' L1 on Their Emerging L2

    ERIC Educational Resources Information Center

    Park, Eun Sung

    2013-01-01

    This study examines novice learners' self-generated input noticing approaches and strategies. It is motivated by previous research on input enhancement which yielded insights that learners are naturally prone to notice certain aspects of L2 input on their own without any external means to channel their attention. Two L1 groups (Japanese and…

  8. NeuralAct: A Tool to Visualize Electrocortical (ECoG) Activity on a Three-Dimensional Model of the Cortex.

    PubMed

    Kubanek, Jan; Schalk, Gerwin

    2015-04-01

    Electrocorticography (ECoG) records neural signals directly from the surface of the cortex. Due to its high temporal and favorable spatial resolution, ECoG has emerged as a valuable new tool in acquiring cortical activity in cognitive and systems neuroscience. Many studies using ECoG visualized topographies of cortical activity or statistical tests on a three-dimensional model of the cortex, but a dedicated tool for this function has not yet been described. In this paper, we describe the NeuralAct package that serves this purpose. This package takes as input the 3D coordinates of the recording sensors, a cortical model in the same coordinate system (e.g., Talairach), and the activation data to be visualized at each sensor. It then aligns the sensor coordinates with the cortical model, convolves the activation data with a spatial kernel, and renders the resulting activations in color on the cortical model. The NeuralAct package can plot cortical activations of an individual subject as well as activations averaged over subjects. It is capable to render single images as well as sequences of images. The software runs under Matlab and is stable and robust. We here provide the tool and describe its visualization capabilities and procedures. The provided package contains thoroughly documented code and includes a simple demo that guides the researcher through the functionality of the tool. PMID:25381641

  9. A learner centered Student Observation Driven Astronomy (SODA)course

    NASA Astrophysics Data System (ADS)

    Bottorff, Mark; Doty, S.; Heaton, J.

    2011-01-01

    The non-science major astronomy course, Exploring the Universe, at Southwestern University is now a Student Observation Driven Astronomy (SODA) course. This minimal lecture course emphasizes using student collected observations to infer basic astronomical information about the universe. Observational data is obtained using small telescopes, inexpensive imaging cameras, and reticule eyepieces. The data are collectively analyzed by students in the classroom. In this poster we present the SODA activities that have been successfully carried out in this learner centered course.

  10. Potential long-acting anticonvulsants. 2. Synthesis and activity of succinimides containing an alkylating group on nitrogen or at the 3 position.

    PubMed

    Kornet, M J; Crider, A M; Magarian, E O

    1977-09-01

    The synthesis of succinimide derivatives in which alkylating groups have been attached to the imide nitrogen or to the 3 position of the ring is described. The synthesis of one bis-alkylating derivative 19 is also described. The alkylating groups used were (a) alpha-haloacetyl, (b) alpha-haloacetamido, (c) maleamyl, and (d) maleimido. These compounds were prepared as potential long-acting anticonvulsants. None of the compounds showed activity against maximal electroshock or metrazole-induced seizures. PMID:926123

  11. Initial Assessment: A Learner Centred Process.

    ERIC Educational Resources Information Center

    Green, Muriel

    This document contains a booklet and companion CD-ROM that introduce and describe a learner-centered assessment process for assessing students' basic skills upon entry into post-16 provision at further education colleges in the United Kingdom. After introducing the concept of learner-centered assessment, the booklet outlines a comprehensive,…

  12. "Harry Potter" and the English Language Learner.

    ERIC Educational Resources Information Center

    Coatney, Kathy

    2001-01-01

    Describes one teacher's success with using "Harry Potter" in a program to teach elementary school English language learners. Provides comprehension strategies incorporated to help learners understand the story. Highlights the importance of creating a classroom environment with a low level of anxiety, the implications of the program, and the value…

  13. Can Code Switching Enhance Learners' Academic Achievement?

    ERIC Educational Resources Information Center

    Simasiku, Liswani; Kasanda, Choshi; Smit, Talita

    2015-01-01

    There has been a high failure rate of Grade 10 learners in the year end examinations in the Caprivi Education Region of Namibia over a number of years. The objective of this study was to investigate whether the use of mother tongue in English medium classrooms enhanced learners' academic achievement.The study investigated 12 teachers at 12 schools…

  14. Learner Uptake in Communicative ESL Lessons.

    ERIC Educational Resources Information Center

    Ellis, Rod; Basturkmen, Helen; Loewen, Shawn

    2001-01-01

    Examines incidental and transitory focus on form. Learner uptake was studied in focus-on-form episodes occurring in 12 hours of communicative English-as-a-Second-Language teaching. Learner uptake was generally high and successful--to a much greater extent than has been reported for immersion classrooms. (Author/VWL)

  15. Dealing with Disruptive Behavior of Adult Learners

    ERIC Educational Resources Information Center

    Dobmeier, Robert; Moran, Joseph

    2008-01-01

    The adult education literature on disruptive behavior of adult learners was reviewed and a survey on disruptive behavior of adult learners was conducted with adult educators. The findings are synthesized in a conceptual framework for understanding the types and causes of disruptive behavior, which fall into the categories of inattention,…

  16. Vocabulary Growth of the Advanced EFL Learner

    ERIC Educational Resources Information Center

    Ozturk, Meral

    2015-01-01

    This article reports the results of two studies on the vocabulary growth of advanced learners of English as a foreign language in an English-medium degree programme. Growth in learners' written receptive and productive vocabularies was investigated in one cross-sectional and one longitudinal study over three years. The effect of word…

  17. Adult Language Learners: Context and Innovation

    ERIC Educational Resources Information Center

    Smith, Ann F. V., Ed.; Strong, Gregory, Ed.

    2009-01-01

    "Adult Language Learners: Context and Innovation" presents instructional practices that are particularly successful with adults. Adult language learners are goal oriented and direct their learning to fulfill particular needs or demands: to advance their studies, to progress up the career ladder, to follow business opportunities, to pass a driving…

  18. Successfully Applying Team Teaching with Adult Learners

    ERIC Educational Resources Information Center

    Laughlin, Kevin; Nelson, Peggy; Donaldson, Susan

    2011-01-01

    Team teaching is a great strategy to convey systems thinking to students, families, and communities and to help learners gain multiple perspectives. Learners benefit from the professional interaction among skilled instructors. This article uses a program of land stewardship to demonstrate the advantages of team teaching. Both the advantages and…

  19. TRANSLATE: New Strategic Approaches for English Learners

    ERIC Educational Resources Information Center

    Goodwin, Amanda P.; Jiménez, Robert

    2016-01-01

    This teaching tip shares a research-based instructional model that uses translation to improve the English reading comprehension of English Learners. Within this instruction, English learners work collaboratively in small groups and use translation to facilitate understandings of their required English language arts curriculum. Students are taught…

  20. Attitudes of EFL Learners towards the Internet

    ERIC Educational Resources Information Center

    Aydin, Selami

    2007-01-01

    Related literature indicates that the Internet has an important role and great potential in foreign language learning. It is also obvious that attitudes of learners affect learning process significantly. This study aimed to investigate the attitudes of foreign language learners and to find the relationship between attitudes and subject variables.…

  1. Coping with Demotivation: EFL Learners' Remotivation Processes

    ERIC Educational Resources Information Center

    Falout, Joseph

    2012-01-01

    When foreign language education is compulsory, competitive, or coercive, how learners cope with stress can determine outcomes, including value of the subject, persistence on task, and level of proficiency. The development of adaptive or maladaptive coping processes toward situated learning goals is influenced by learners' beliefs about themselves…

  2. Learning Strategies Used by Successful Language Learners

    ERIC Educational Resources Information Center

    Thu, Tran Hoang

    2009-01-01

    This study examines the language learning strategies employed by successful learners of English as a foreign and second language. Two successful English learners whose first languages are Mandarin were interviewed, and asked to complete a questionnaire and a self-evaluation measure to indicate their perceived level of language proficiency as well…

  3. Build Optional Digital Textbooks for Distance Learners

    ERIC Educational Resources Information Center

    Ruo, Du; Xiaotang, Yang

    2013-01-01

    E-books seem to be a trend and an excellent solution for mobile learning lately, but what kinds of e-books are good fit for distance learners' needs? For the purpose of offering open, more appropriate, better in quality, more convenient and flexible learning materials for distance learners. From 2011, through an experimental study on the basis of…

  4. Life Skills Curriculum for Senior Adult Learners.

    ERIC Educational Resources Information Center

    Leon County Schools, Tallahassee, FL.

    This life skills curriculum helps adult basic educators meet the needs of senior adult learners. An introduction contains the following sections: purpose statement; description of the senior adult learner; tips to remember on teaching senior adults; physiology of aging; teaching the hearing impaired; and teaching the visually impaired. The life…

  5. Using Learner Data in Curriculum Development.

    ERIC Educational Resources Information Center

    Nunan, David

    1990-01-01

    Describes an approach to curriculum development that has evolved out of a learner-centered philosophy of second and foreign language teaching. The use of information about and from learners for decision-making at each of these stages is illustrated with data from the Australian Adult Immigrant Education Program. (Author/VWL)

  6. Technologies for Learner-Centered Feedback

    ERIC Educational Resources Information Center

    Costello, Jane; Crane, Daph

    2013-01-01

    As the number, type, and use of technologies to support learning increases, so do the opportunities for using these technologies for feedback. Learner-centered feedback is a core to the teaching-learning process. It is related to assessment in describing how learners perform in their learning, their gain in knowledge, skills, and attitudes.…

  7. Reading Assessment and Instruction for All Learners

    ERIC Educational Resources Information Center

    Schumm, Jeanne Shay, Ed.

    2006-01-01

    Weaving together the latest knowledge and best practices for teaching children to read, this indispensable text and professional resource provides a complete guide to differentiated instruction for diverse learners. Uniquely integrative, the book places the needs of English language learners and students with disabilities front and center instead…

  8. Profiles of English Learners (ELs). Fast Facts

    ERIC Educational Resources Information Center

    Office of English Language Acquisition, US Department of Education, 2015

    2015-01-01

    The Office of English Language Acquisition (OELA) has synthesized key data on English learners (ELs) into two-page PDF sheets, by topic, with graphics, plus key contacts. The topics for this report on profiles of English Learners (ELs) include: (1) Percentage of Total School Population, Grades Pre-K through 12, Represented by ELs, by State,…

  9. ICT Usage by Distance Learners in India

    ERIC Educational Resources Information Center

    Awadhiya, Ashish Kumar; Gowthaman, K.

    2014-01-01

    Open Universities across the world are embracing ICT based teaching and learning process to disseminate quality education to their learners spread across the globe. In India availability and access of ICT and learner characteristics are uneven and vary from state to state. Hence it is important to establish the facts about ICT access among…

  10. Valuing the Advanced Learner: Differentiating up

    ERIC Educational Resources Information Center

    Manning, Sandra; Stanford, Barbara; Reeves, Stacy

    2010-01-01

    In today's educational climate, differentiated instruction is a common practice for students who need remediation; what is less common is to Differentiate Instruction for the advanced learner. Contrary to popular perceptions, advanced learners do not automatically differentiate instruction on their own. Students who have the potential to excel…

  11. Learners' Mental Models of Chemical Bonding.

    ERIC Educational Resources Information Center

    Coll, Richard K.; Treagust, David F.

    2001-01-01

    Reports on a study involving two each year-12, undergraduate and postgraduate Australian students. Elicits learners' mental models for chemical bonding using semi-structured interviews comprising a three-phase interview protocol. Concludes that learners across all three academic levels preferred simple, realistic mental models for chemical…

  12. Vocabulary Breadth in French L2 Learners

    ERIC Educational Resources Information Center

    David, Annabelle

    2008-01-01

    Vocabulary is one of the building blocks of language and is a necessary component of learners' development. This paper aims to describe the development of the L2 lexicon from the first year of learning French as a foreign language at school to the last year of undergraduate studies at university by setting out what learners know and how this…

  13. Online Learner's "Flow" Experience: An Empirical Study

    ERIC Educational Resources Information Center

    Shin, Namin

    2006-01-01

    This study is concerned with online learners' "low" experiences. On the basis of Csikszentmihalyi's theory of flow, flow was conceptualised as a complex, multimentional, reflective construct composing of "enjoyment", "telepresence", "focused attention", "engagement" and "time distortion" on the part of learners. A flow model was put forward with…

  14. English Learners (ELs) and NAEP. Fast Facts

    ERIC Educational Resources Information Center

    Office of English Language Acquisition, US Department of Education, 2015

    2015-01-01

    The Office of English Language Acquisition (OELA) has synthesized key data on English learners (ELs) into two-page PDF sheets, by topic, with graphics, plus key contacts. The topics for this report on English Learners (ELs) and NAEP include: (1) 2013 Reading Scores for Grades 4, 8, and 12: ELs vs. Non-ELs; (2) 2013 Mathematics Scores for Grades 4,…

  15. A Factor Analysis of Learner Characteristics.

    ERIC Educational Resources Information Center

    Frymier, Jack; Bills, Robert E.

    The purpose of this study was to determine whether terms used in the Annehurst Curriculum Classification System (ACCS) are appropriate and useful to describe learner characteristics. From the twelve characteristics postulated in the ACCS to describe learners, six were selected for study: experience, intelligence, motivation, emotion-personality,…

  16. Learner Language Analytic Methods and Pedagogical Implications

    ERIC Educational Resources Information Center

    Dyson, Bronwen

    2010-01-01

    Methods for analysing interlanguage have long aimed to capture learner language in its own right. By surveying the cognitive methods of Error Analysis, Obligatory Occasion Analysis and Frequency Analysis, this paper traces reformulations to attain this goal. The paper then focuses on Emergence Analysis, which fine-tunes learner language analysis…

  17. Engaging the Adult Learner Generational Mix

    ERIC Educational Resources Information Center

    Holyoke, Laura; Larson, Erick

    2009-01-01

    Educators and Trainers both focus on adult learning theory when teaching. In the workforce, as well as in higher education, current literature pertaining to adult learners tends to lump all adults into the same category. Scant research exists that reviews the adult learner through a generational lens. This paper examines the elements that engage…

  18. Learner Views about a Distance Education Course

    ERIC Educational Resources Information Center

    Durak, Gurhan; Ataizi, Murat

    2016-01-01

    The purpose of the study was to investigate the views of learners experienced in the Distance Learning Platform (DLP), which was prepared according to an online course design model. The participants of the study were 19 learners who took the programming languages course (via the DLP for 14 weeks). Before the application, the preparation of the DLP…

  19. Disabled Learners' Experiences of E-Learning

    ERIC Educational Resources Information Center

    Wald, Mike; Draffan, E. A.; Seale, Jane

    2009-01-01

    This article provides an overview and initial findings of the LExDis project which is exploring the e-learning experiences of disabled learners within a UK university in order to increase understanding of the many complex issues and interactions introduced by disabled learners' requirements for accessible e-learning, compatible assistive…

  20. Identifying Successful Learners from Interaction Behaviour

    ERIC Educational Resources Information Center

    McCuaig, Judi; Baldwin, Julia

    2012-01-01

    The interaction behaviours of successful, high-achieving learners when using a Learning Management System (LMS) are different than the behaviours of learners who are having more difficulty mastering the course material. This paper explores the idea that conventional Learning Management Systems can exploit data mining techniques to predict the…