Science.gov

Sample records for activity learners act

  1. English Language Learners in the Elementary and Secondary Education Act

    ERIC Educational Resources Information Center

    Calderon, Brenda

    2015-01-01

    The Elementary and Secondary Education Act has provided services for English Language Learners (ELLs) since 1968. In 2010 nearly 4.6 million students were classified as ELLs and of those nearly 80% were from a Spanish speaking background. To ignore their education is to neglect preparing a large portion of our nation's future workforce. Given…

  2. Acting out: Using Drama with English Learners

    ERIC Educational Resources Information Center

    Bernal, Penny

    2007-01-01

    High school teacher Penny Bernal reflects on the success of using drama in her English Language Development classroom over the past ten years. She shares various steps for preparing a play as a means of promoting language learning and literacy, such as familiarizing students with language intonations through toning activities, practicing stage…

  3. English Language Learners and the No Child Left Behind Act of 2001

    ERIC Educational Resources Information Center

    Tran, Thu Hoang

    2009-01-01

    This literature review looks at the impacts of the No Child Left Behind Act (NCLB) of 2001 on English language learners (ELLs), educators and schools. A brief overview of the current state of English as a second language teaching for adult learners will first be described. Then the importance of the enactment of the NCLB of 2001 is mentioned. Both…

  4. Diverse Learners. Reauthorizing the Elementary and Secondary Education Act

    ERIC Educational Resources Information Center

    US Department of Education, 2010

    2010-01-01

    To achieve President Obama's stated goal of including all of America's students in leading the world in education, the administration has designed a blueprint for a reenvisioned federal role in education through the reauthorization of the "Elementary and Secondary Education Act" ("ESEA"). The new "ESEA" will ensure…

  5. The Realization of the Speech Act of Refusal in Egyptian Arabic by American Learners of Arabic as a Foreign Language

    ERIC Educational Resources Information Center

    Morkus, Nader

    2009-01-01

    This study investigated how the speech act of refusal is realized in Egyptian Arabic by intermediate and advanced American learners of Arabic as a foreign language. It also compared the performance of the learners to that of native speakers of Egyptian Arabic and native speakers of American English. The study aimed to investigate the relationship…

  6. Getting Your Speech Act Together: The Pragmatic Ability of Second Language Learners. Working Papers on Bilingualism, No. 17.

    ERIC Educational Resources Information Center

    Rintell, Ellen

    A role-playing procedure for elicitation of speech acts was designed to study aspects of the communicative competence of second language learners, namely, their language variation with respect to deference when the age and sex of the addressee are systematically manipulated. Sixteen Spanish-speaking adult learners of English as a second language…

  7. Learner Activities in a Collaborative CALL Task

    ERIC Educational Resources Information Center

    Leahy, C.

    2008-01-01

    This paper briefly discusses different research approaches in CALL and makes a case for applying grounded theory (GT) to data gathered from an electronic role-play conducted in L2. The article shows that this method can help gain a better understanding of what learners do when engaged in the task. Through the process of open coding, four…

  8. We are what we do: Examining learner-generated content in the anatomy laboratory through the lens of activity theory.

    PubMed

    Doubleday, Alison F; Wille, Sarah J

    2014-01-01

    Video and photography are often used for delivering content within the anatomical sciences. However, instructors typically produce these resources to provide instructional or procedural information. Although the benefits of learner-generated content have been explored within educational research, virtually no studies have investigated the use of learner-generated video and photograph content within anatomy dissection laboratories. This study outlines an activity involving learner-generated video diaries and learner-generated photograph assignments produced during anatomy laboratory sessions. The learner-generated photographs and videos provided instructors with a means of formative assessment and allowed instructors to identify evidence of collaborative behavior in the laboratory. Student questionnaires (n = 21) and interviews (n = 5), as well as in-class observations, were conducted to examine student perspectives on the laboratory activities. The quantitative and qualitative data were examined using the framework of activity theory to identify contradictions between student expectations of, and engagement with, the activity and the actual experiences of the students. Results indicate that learner-generated photograph and video content can act as a rich source of data on student learning processes and can be used for formative assessment, for observing collaborative behavior, and as a starting point for class discussions. This study stresses the idea that technology choice for activities must align with instructional goals. This research also highlights the utility of activity theory as a framework for assessing classroom and laboratory activities, demonstrating that this approach can guide the development of laboratory activities.

  9. Interactions between and among Heritage Language Learners and Second Language Learners during Collaborative Writing Activities: How Learners Attend to Language

    ERIC Educational Resources Information Center

    Walls, Laura

    2013-01-01

    This study investigates the dynamics in the Spanish classroom between heritage language learner (HLL) dyads, second language learner (L2L) dyads, and mixed HLL-L2L dyads. Specifically, it examines oral, written and embodied discourse that informs our understanding of how learners attend to language. Analysis for this dissertation examined…

  10. Learner-Interface Interaction for Technology-Enhanced Active Learning

    ERIC Educational Resources Information Center

    Sinha, Neelu; Khreisat, Laila; Sharma, Kiron

    2009-01-01

    Neelu Sinha, Laila Khreisat, and Kiron Sharma describe how learner-interface interaction promotes active learning in computer science education. In a pilot study using technology that combines DyKnow software with a hardware platform of pen-enabled HP Tablet notebook computers, Sinha, Khreisat, and Sharma created dynamic learning environments by…

  11. Young Children: Active Learners in a Technological Age.

    ERIC Educational Resources Information Center

    Wright, June L., Ed.; Shade, Daniel D., Ed.

    This book addresses the issues of appropriate use of computers with young children and how children and early childhood educators interact with the computer in early childhood settings. Part 1, "Young Children as Active Learners," contains chapter 1: "Listen to the Children: Observing Young Children's Discoveries with the…

  12. Facebook Activities and the Investment of L2 Learners

    ERIC Educational Resources Information Center

    Shafie, Latisha Asmaak; Yaacob, Aizan; Singh, Paramjit Kaur Karpal

    2016-01-01

    The article discusses the investment of L2 learners in the English language on Facebook that they portrayed through their Facebook activities. It studied four informants consisted of diploma students in a Malaysian university. The study consisted of 14 weeks of online observation and semi-structured interviews. Data were collected from online…

  13. Does Translation Contribute to Learners' Free Active Vocabulary?

    ERIC Educational Resources Information Center

    Asiyaban, Amir R.; Bagheri, Mohammad S.

    2012-01-01

    This research was conducted to find out whether or not using "translation" technique in vocabulary teaching would have any positive effects on the "free active" vocabulary of Iranian learners of English. To carry out the research, eighty-eight intermediate male and female students were chosen. The participants were divided into…

  14. Acquisition of Mathematical Language: Suggestions and Activities for English Language Learners

    ERIC Educational Resources Information Center

    Cirillo, Michelle; Bruna, Katherine Richardson; Herbel-Eisenmann, Beth

    2010-01-01

    In this article, we describe aspects of mathematical language that could be problematic to English-language learners, provide recommendations for teaching English-language learners, and suggest activities intended to foster language development in mathematics. (Contains 1 figure.)

  15. Learning activism, acting with phronesis

    NASA Astrophysics Data System (ADS)

    Lee, Yew-Jin

    2015-12-01

    The article "Socio-political development of private school children mobilising for disadvantaged others" by Darren Hoeg, Natalie Lemelin, and Lawrence Bencze described a language-learning curriculum that drew on elements of Socioscientific issues and Science, Technology, Society and Environment. Results showed that with a number of enabling factors acting in concert, learning about and engagement in practical action for social justice and equity are possible. An alternative but highly compatible framework is now introduced—phronetic social research—as an action-oriented, wisdom-seeking research stance for the social sciences. By so doing, it is hoped that forms of phronetic social research can gain wider currency among those that promote activism as one of many valued outcomes of an education in science.

  16. Learners' Perceptions of Instructional Design Practice in a Situated Learning Activity

    ERIC Educational Resources Information Center

    Woolf, Nicholas; Quinn, James

    2009-01-01

    This case study investigated learners' perceptions of value from participating in a learning activity designed to model professional instructional design practice. Learners developed instructional design products for a corporate client in the context of a classroom-based course. The findings indicate that learners perceived different kinds of…

  17. A Balancing Act: How Can Intelligent Computer-Generated Feedback Be Provided in Learner-to-Learner Interactions?

    ERIC Educational Resources Information Center

    Dickinson, Markus; Eom, Soojeong; Kang, Yunkyoung; Lee, Chong Min; Sachs, Rebecca

    2008-01-01

    Task-based synchronous computer-mediated communication (CMC) may represent an optimal psycholinguistic environment for form-meaning connections, but learners do not receive feedback from a trusted authority. Intelligent computer-assisted language learning (ICALL) provides feedback, but the encouragement of communicative interaction remains largely…

  18. Textbook Activities among Heritage and Non-Heritage Portuguese Learners

    ERIC Educational Resources Information Center

    Silva, Glaucia V.

    2011-01-01

    Over the past four decades, scholars have debated the pedagogical and sociolinguistic needs of heritage language learners. It is widely accepted that these learners present several characteristics that are different from those of foreign (or non-heritage) language learners. However, scholars have also pointed to similarities between the two groups…

  19. Does Active Learning Enhance Learner Outcomes? Evidence from Discussion Participation in Online Classes

    ERIC Educational Resources Information Center

    Wilson, Bruce M.; Pollock, Philip H.; Hamann, Kerstin

    2007-01-01

    Discussion is one form of active learning, which has been linked to better learner outcomes. Little is known about the relationship between active learning through discussion and learner outcome in the online environment. Here, we construct an index of active learning online that includes the number of postings a student has read, the number of…

  20. A Cross-Cultural Study of Offering Advice Speech Acts by Iranian EFL Learners and English Native Speakers: Pragmatic Transfer in Focus

    ERIC Educational Resources Information Center

    Babaie, Sherveh; Shahrokhi, Mohsen

    2015-01-01

    The purpose of the present study was to compare the speech act of offering advice as realized by Iranian EFL learners and English native speakers. The study, more specifically, attempted to find out whether there was any pragmatic transfer from Persian (L1) among Iranian EFL learners while offering advice in English. It also examined whether…

  1. Promoting Physics Among Female Learners in the Western Cape Through Active Engagement (abstract)

    NASA Astrophysics Data System (ADS)

    Arendse, Gillian J.

    2009-04-01

    In 2006 the author organized a one-day intervention aimed at promoting physics among female learners at the University of Stellenbosch. The activities included an interactive lecture demonstration promoting active engagement, a hands-on session, and short presentations by female physicists addressing issues such as balancing family and career, breaking the stereotypes, and launching a successful career in physics. Each learner was expected to evaluate the program. In 2007 the author joined forces with Hip2B2 (Shuttleworth Foundation) to host a competition among grade-10 learners with the theme, ``promoting creativity through interactivity.'' The author was tasked by the Hip2B2-team to assist with a program for female learners planned for August 2008, coinciding with our national celebration of Women's Day. The event targeted 160 learners and took place in Durban, East London, Cape Town, and Johannesburg. The author shares some of the learners' experiences and personal triumphs.

  2. How Do Distance Learners Use Activities in Self-Instructional Materials?

    ERIC Educational Resources Information Center

    Mishra, Sanjaya; Gaba, Ashok Kumar

    2001-01-01

    Presents results of a study on the use of learning activities in self-instructional materials by distance learners of the Indira Gandhi National Open University (IGNOU). It shows that learners make use of the activities extensively as they have positive perceptions about benefits of Self-Assessment Questions and Terminal Questions given in the…

  3. Investigating Learner Attitudes toward E-Books as Learning Tools: Based on the Activity Theory Approach

    ERIC Educational Resources Information Center

    Liaw, Shu-Sheng; Huang, Hsiu-Mei

    2016-01-01

    This paper investigates the use of e-books as learning tools in terms of learner satisfaction, usefulness, behavioral intention, and learning effectiveness. Based on the activity theory approach, this research develops a research model to understand learner attitudes toward e-books in two physical sizes: 10? and 7?. Results suggest that screen…

  4. Training Learners to Use Quizlet Vocabulary Activities on Mobile Phones in Vietnam with Facebook

    ERIC Educational Resources Information Center

    Tran, Phuong

    2016-01-01

    Mobile phone ownership among university students in Vietnam has reached almost 100%, exceeding that of Internet-capable desktop computers. This has made them increasingly popular to allow learners to carry out learning activities outside of the classroom, but some studies have suggested that learners are not always willing to engage in activities…

  5. Beginning Learners' Development of Interactional Competence: Alignment Activity

    ERIC Educational Resources Information Center

    Tecedor, Marta

    2016-01-01

    This study examined the development of interactional competence (Hall, 1993; He & Young, 1998) by beginning learners of Spanish as indexed by their use of alignment moves. Discourse analysis techniques and quantitative data analysis were used to explore how 52 learners expressed alignment and changes in participation patterns in two sets of…

  6. Spoken Language Activation Alters Subsequent Sign Language Activation in L2 Learners of American Sign Language.

    PubMed

    Williams, Joshua T; Newman, Sharlene D

    2017-02-01

    A large body of literature has characterized unimodal monolingual and bilingual lexicons and how neighborhood density affects lexical access; however there have been relatively fewer studies that generalize these findings to bimodal (M2) second language (L2) learners of sign languages. The goal of the current study was to investigate parallel language activation in M2L2 learners of sign language and to characterize the influence of spoken language and sign language neighborhood density on the activation of ASL signs. A priming paradigm was used in which the neighbors of the sign target were activated with a spoken English word and compared the activation of the targets in sparse and dense neighborhoods. Neighborhood density effects in auditory primed lexical decision task were then compared to previous reports of native deaf signers who were only processing sign language. Results indicated reversed neighborhood density effects in M2L2 learners relative to those in deaf signers such that there were inhibitory effects of handshape density and facilitatory effects of location density. Additionally, increased inhibition for signs in dense handshape neighborhoods was greater for high proficiency L2 learners. These findings support recent models of the hearing bimodal bilingual lexicon, which posit lateral links between spoken language and sign language lexical representations.

  7. Exploring Primary Care Activities in ACT Teams

    PubMed Central

    Vanderlip, Erik R.; Williams, Nancy A.; Fiedorowicz, Jess G.; Katon, Wayne

    2014-01-01

    Background People with serious mental illness often receive inadequate primary and preventive care services. Federal healthcare reform endorses team-based care that provides high quality primary and preventive care to at risk populations. Assertive Community Treatment (ACT) teams offer a proven, standardized treatment approach effective in improving mental health outcomes for the seriously mentally ill. Much is known about the effectiveness of ACT teams in improving mental health outcomes, but the degree to which medical care needs are addressed is not established. Purpose The purpose of this study was to explore the extent to which ACT teams address the physical health of the population they serve. Methods ACT team leaders were invited to complete an anonymous, web-based survey to explore attitudes and activities involving the primary care needs of their clients. Information was collected regarding the use of health screening tools, physical health assessments, provision of medical care and collaboration with primary care systems. Results Data was analyzed from 127 team leaders across the country, of which 55 completed the entire survey. Nearly every ACT team leader believed ACT teams have a role in identifying and managing the medical co-morbidities of their clientele. ACT teams report participation in many primary care activities. Conclusions ACT teams are providing a substantial amount of primary and preventive services to their population. The survey suggests standardization of physical health identification, management or referral processes within ACT teams may result in improved quality of medical care. ACT teams are in a unique position to improve physical health care by virtue of having medically trained staff and frequent, close contact with their clients. PMID:24337472

  8. Investigating the Explicit Instruction of Apology Speech Act on Pragmatic Development of Iranian EFL Learners

    ERIC Educational Resources Information Center

    Rajabi, Shima; Azizifar, Akbar; Gowhary, Habib

    2015-01-01

    Learning a foreign language requires students to acquire both grammatical knowledge and socio-pragmatic rules of a language. Pragmatic competence as one of the most difficult aspects of language provides several challenges to L2 learners in the process of learning a foreign language. To overcome this problem, EFL teachers should find the most…

  9. Realization of Speech Acts of Refusals and Pragmatic Competence by Turkish EFL Learners

    ERIC Educational Resources Information Center

    Han, Turgay; Burgucu-Tazegül, Assiye

    2016-01-01

    The purpose of the present study is to examine a) how lower-intermediate and upper-intermediate level Turkish learners of English-as-a-foreign language (EFL) realize refusals in English, b) the differences between native and non-native speakers of English in the use of refusals, and c) if L2 proficiency affects possible pragmatic transfer or not.…

  10. Balancing Act: A Phenomenological Study of Female Adult Learners Who Successfully Persisted in Graduate Studies

    ERIC Educational Resources Information Center

    Shepherd, Jeff; Nelson, Barbara Mullins

    2012-01-01

    A study was conducted utilizing Cross' (1981) barriers to adult learning as a framework to better understand how adults successfully complete their graduate studies. Participants in the study were solicited via Facebook and LinkedIn. Three female adult learners who persisted in their graduate studies while balancing demands outside academics…

  11. Study Abroad and Interlanguage Pragmatic Development in Request and Apology Speech Acts among Iranian Learners

    ERIC Educational Resources Information Center

    Khorshidi, Hassan Rasouli

    2013-01-01

    This research study empirically investigated the impact of study abroad context on L2 learners' pragmatic development compared with study at home group in Iran. For the study abroad group the participants were selected from the Iranian students who registered in a six-month program in language institutes in India (Mysore) and for the study at home…

  12. Learners' Interpersonal Beliefs and Generated Feedback in an Online Role-Playing Peer-Feedback Activity: An Exploratory Study

    ERIC Educational Resources Information Center

    Ching, Yu-Hui; Hsu, Yu-Chang

    2016-01-01

    Peer feedback affords interaction and critical thinking opportunities for learners in online courses. However, various factors prevent learners from taking advantage of these promising benefits. This study explored learners' perceptions of the interpersonal factors in a role-playing peer-feedback activity, and examined the types of peer feedback…

  13. Pragmatic Difficulties in the Production of the Speech Act of Apology by Iraqi EFL Learners

    ERIC Educational Resources Information Center

    Al-Ghazalli, Mehdi Falih; Al-Shammary, Mohanad A. Amert

    2014-01-01

    The purpose of this paper is to investigate the pragmatic difficulties encountered by Iraqi EFL university students in producing the speech act of apology. Although the act of apology is easy to recognize or use by native speakers of English, non-native speakers generally encounter difficulties in discriminating one speech act from another. The…

  14. A Development of Game-Based Learning Environment to Activate Interaction among Learners

    NASA Astrophysics Data System (ADS)

    Takaoka, Ryo; Shimokawa, Masayuki; Okamoto, Toshio

    Many studies and systems that incorporate elements such as “pleasure” and “fun” in the game to improve a learner's motivation have been developed in the field of learning environments. However, few are the studies of situations where many learners gather at a single computer and participate in a game-based learning environment (GBLE), and where the GBLE designs the learning process by controlling the interactions between learners such as competition, collaboration, and learning by teaching. Therefore, the purpose of this study is to propose a framework of educational control that induces and activates interaction between learners intentionally to create a learning opportunity that is based on the knowledge understanding model of each learner. In this paper, we explain the design philosophy and the framework of our GBLE called “Who becomes the king in the country of mathematics?” from a game viewpoint and describe the method of learning support control in the learning environment. In addition, we report the results of the learning experiment with our GBLE, which we carried out in a junior high school, and include some comments by a principal and a teacher. From the results of the experiment and some comments, we noticed that a game may play a significant role in weakening the learning relationship among students and creating new relationships in the world of the game. Furthermore, we discovered that learning support control of the GBLE has led to activation of the interaction between learners to some extent.

  15. Learner-Centered Activities from the DVD-Format "Crouching Tiger, Hidden Dragon."

    ERIC Educational Resources Information Center

    Lin, Li-Yun

    This paper demonstrates how Taiwanese English-as-a-Second-Language (ESL) college teachers and students collaborate and negotiate to design various learner-centered activities based on the Chinese film, "Crouching Tiger, Hidden Dragon." These activities are intended to enhance students' listening and speaking abilities. The paper…

  16. What Does Metalinguistic Activity in Learners' Interaction during a Collaborative L2 Writing Task Look Like?

    ERIC Educational Resources Information Center

    Gutierrez, Xavier

    2008-01-01

    This article examines the metalinguistic activity that arose in the interaction of 7 groups of bilingual learners writing collaboratively in their second language (L2), English. A microanalysis of this interaction reveals that metalinguistic activity comprises 3 types of oral production: comments, speech actions, and text reformulations. Text…

  17. Federal Acts Relating to Continuing Education and Public Service Activities.

    ERIC Educational Resources Information Center

    Pennsylvania State Univ., University Park. Center for Continuing Liberal Education.

    A listing is given, with brief descriptions, of Acts of Congress which relate to continuing education and public service activities. Forty-nine laws specifically authorize funds for continuing education and public service programs (Adult Education Act of 1966, Higher Education Act of 1965, Omnibus Crime Control and Safe Streets Act of 1968, Older…

  18. The Effects of Pre-Reading Activities on Reading Comprehension of Iranian EFL Learners

    ERIC Educational Resources Information Center

    Moghaddam, Nahid Nemati; Mahmoudi, Asgar

    2016-01-01

    This study investigated the effects of three types of pre-reading activities (movie-watching, vocabulary presentation, and pre-reading summarization) on the reading comprehension of 76 elementary-level EFL Iranian learners. The participants were randomly assigned to one control and three experimental conditions and then a pretest was given to…

  19. Active Learning for Discovery and Innovation in Criminology with Chinese Learners

    ERIC Educational Resources Information Center

    Li, Jessica C. M.; Wu, Joseph

    2015-01-01

    Whereas a great deal of literature based upon the context of Western societies has concluded criminology is an ideal discipline for active learning approach, it remains uncertain if this learning approach is applicable to Chinese learners in the discipline of criminology. This article describes and provides evidence of the benefits of using active…

  20. Investigating the Use of Inquiry & Web-Based Activities with Inclusive Biology Learners

    ERIC Educational Resources Information Center

    Bodzin, Alec M.; Waller, Patricia L.; Edwards, Lana; Darlene Kale, Santoro

    2007-01-01

    A Web-integrated biology program is used to explore how to best assist inclusive high school students to learn biology with inquiry-based activities. Classroom adaptations and instructional strategies teachers may use to assist in promoting biology learning with inclusive learners are discussed.

  1. An Emergent Language Program Framework: Actively Involving Learners in Needs Analysis.

    ERIC Educational Resources Information Center

    Savage, William; Storer, Graeme

    1992-01-01

    Relates the experience of the staff of an aquaculture outreach program in Northeast Thailand in implementing an English for special purposes program. By actively involving learners in both the needs analysis and program design, teachers were able to adapt the program content to the requirements of the students. (15 references) (JL)

  2. Cross-Language Activation in Children's Speech Production: Evidence from Second Language Learners, Bilinguals, and Trilinguals

    ERIC Educational Resources Information Center

    Poarch, Gregory J.; van Hell, Janet G.

    2012-01-01

    In five experiments, we examined cross-language activation during speech production in various groups of bilinguals and trilinguals who differed in nonnative language proficiency, language learning background, and age. In Experiments 1, 2, 3, and 5, German 5- to 8-year-old second language learners of English, German-English bilinguals,…

  3. Flipping the Classroom for English Language Learners to Foster Active Learning

    ERIC Educational Resources Information Center

    Hung, Hsiu-Ting

    2015-01-01

    This paper describes a structured attempt to integrate flip teaching into language classrooms using a WebQuest active learning strategy. The purpose of this study is to examine the possible impacts of flipping the classroom on English language learners' academic performance, learning attitudes, and participation levels. Adopting a…

  4. Fashion Design: Designing a Learner-Active, Multi-Level High School Course

    ERIC Educational Resources Information Center

    Nelson, Diane

    2009-01-01

    A high school fashion design teacher has much in common with the ringmaster of a three-ring circus. The challenges of teaching a hands-on course are to facilitate the entire class and to meet the needs of individual students. When teaching family and consumer sciences, the goal is to have a learner-active classroom. Revamping the high school's…

  5. Synthesizing Technology Adoption and Learners' Approaches towards Active Learning in Higher Education

    ERIC Educational Resources Information Center

    Chan, Kevin; Cheung, George; Wan, Kelvin; Brown, Ian; Luk, Green

    2015-01-01

    In understanding how active and blended learning approaches with learning technologies engagement in undergraduate education, current research models tend to undermine the effect of learners' variations, particularly regarding their styles and approaches to learning, on intention and use of learning technologies. This study contributes to further…

  6. Popular Culture, English Out-of-Class Activities, and Learner Autonomy among Highly Proficient Secondary Students in Hong Kong

    ERIC Educational Resources Information Center

    Chan, Hoi Wing

    2016-01-01

    This paper reports on how and why proficient learners of English in Hong Kong participated in popular culture, out-of-class activities, with an emphasis on their development of learner autonomy. Autonomy in language learning is defined as an individual's ability and responsibility to take charge of his or her own learning [1]. Out-of-class…

  7. Active Advocacy: Working Together for Appropriate Services for Gifted Learners

    ERIC Educational Resources Information Center

    Wiskow, Kyle; Fowler, V. Dianne; Christopher, Mary M.

    2011-01-01

    The Jacob K. Javits Gifted and Talented Students Act of 1988 provided additional funding for gifted programs and research endeavors. Scholars and educators within the field recognized its passage as a true watershed moment. Despite its unquestioned impact on the lives of countless gifted students around the country, federal lawmakers routinely…

  8. Fluency-dependent cortical activation associated with speech production and comprehension in second language learners.

    PubMed

    Shimada, K; Hirotani, M; Yokokawa, H; Yoshida, H; Makita, K; Yamazaki-Murase, M; Tanabe, H C; Sadato, N

    2015-08-06

    This functional magnetic resonance imaging (fMRI) study investigated the brain regions underlying language task performance in adult second language (L2) learners. Specifically, we identified brain regions where the level of activation was associated with L2 fluency levels. Thirty Japanese-speaking adults participated in the study. All participants were L2 learners of English and had achieved varying levels of fluency, as determined by a standardized L2 English proficiency test, the Versant English Test (Pearson Education Inc., 2011). When participants performed the oral sentence building task from the production tasks administered, the dorsal part of the left inferior frontal gyrus (dIFG) showed activation patterns that differed depending on the L2 fluency levels: The more fluent the participants were, the more dIFG activation decreased. This decreased activation of the dIFG might reflect the increased automaticity of a syntactic building process. In contrast, when participants performed an oral story comprehension task, the left posterior superior temporal gyrus (pSTG) showed increased activation with higher fluency levels. This suggests that the learners with higher L2 fluency were actively engaged in post-syntactic integration processing supported by the left pSTG. These data imply that L2 fluency predicts neural resource allocation during language comprehension tasks as well as in production tasks. This study sheds light on the neural underpinnings of L2 learning by identifying the brain regions recruited during different language tasks across different modalities (production vs. comprehension).

  9. 77 FR 1947 - Agency Information Collection Activities: Jade Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-12

    ... SECURITY U.S. Customs and Border Protection Agency Information Collection Activities: Jade Act AGENCY: U.S... agencies to comment on an information collection requirement concerning the JADE Act. This request for...: Title: JADE Act. OMB Number: 1651-0133. Form Number: None. Abstract: The Tom Lantos Block Burmese...

  10. Sharing a Small World: Environmental Activities for Young Learners.

    ERIC Educational Resources Information Center

    Zero Population Growth, Inc., Washington, DC.

    This booklet contains a collection of activities developed for pre-K through second grade students. All of the activities in this teacher's guide use an interdisciplinary approach and explore the human connection with all living things and their environment. Contents include: (1) "Sharing Space and Working Together"; (2) "Sharing Resources and…

  11. Cross-language activation in children's speech production: evidence from second language learners, bilinguals, and trilinguals.

    PubMed

    Poarch, Gregory J; van Hell, Janet G

    2012-03-01

    In five experiments, we examined cross-language activation during speech production in various groups of bilinguals and trilinguals who differed in nonnative language proficiency, language learning background, and age. In Experiments 1, 2, 3, and 5, German 5- to 8-year-old second language learners of English, German-English bilinguals, German-English-Language X trilinguals, and adult German-English bilinguals, respectively, named pictures in German and in English; in Experiment 4, 6- to 8-year-old German monolinguals named pictures in German. In both language conditions, cognate status was manipulated. We found that the bidirectional cognate facilitation effect was significant in all groups except the German monolinguals (Experiment 4) and, critically, the child second language learners (Experiment 1) in whom only native language (L1) German had an effect on second language (L2) English. The findings demonstrate how the integration of languages into a child's system follows a developmental path that, at lower levels of proficiency, allows only limited cross-language activation. The results are interpreted against the backdrop of the developing language systems of the children both for early second language learners and for early bi- and trilinguals.

  12. The effect of curricular activities on learner autonomy: the perspective of undergraduate mechanical engineering students

    NASA Astrophysics Data System (ADS)

    Duarte, M.; Leite, C.; Mouraz, A.

    2016-01-01

    This study researches how first-year engineering students perceived the influence of curricular activities on their own learning autonomy, measured with an adaptation of the Personal Responsibility Orientation to Self-direction in Learning Scale (PRO-SDLS). Participants were questioned to assess the influence of the teacher's role. The results indicate that learners' characteristics (motivation and self-efficacy) contribute more to learner autonomy (LA) than the teaching-learning transaction (control and initiative), as in the original PRO-SDLS validation. The most autonomous learners presented higher values in all LA components and dimensions, but the differences were greater in motivation and initiative. The participants with higher LA were not as dependent on the teacher, regarding assessment, the completion of classroom tasks and deadlines. Regardless of the degree of autonomy in learning, all participants viewed teachers as the main source of information. Therefore, LA plays an important role in teaching activities planning. Suggestions for adjustments and more flexible learning scenarios are formulated.

  13. Model Eliciting Activities: Fostering 21st Century Learners

    ERIC Educational Resources Information Center

    Stohlmann, Micah

    2013-01-01

    Real world mathematical modeling activities can develop needed and valuable 21st century skills. The knowledge and skills to become adept at mathematical modeling need to develop over time and students in the elementary grades should have experiences with mathematical modeling. For this to occur elementary teachers need to have positive…

  14. ACT/ICAPS: Thermoplastic composite activities

    NASA Technical Reports Server (NTRS)

    Renieri, M. P.; Burpo, S. J.; Roundy, L. M.; Todd, S. M.

    1992-01-01

    McDonnell Aircraft Company (MCAIR) is teamed with Douglas Aircraft Company (DAC) under NASA's Advanced Composite Technology (ACT) initiative in a program entitled Innovative Composite Aircraft Primary Structures (ICAPS). Efforts at MCAIR have focused on the use of thermoplastic composite materials in the development of structural details associated with an advanced fighter fuselage section with applicability to transport design. Based on innovative design/manufacturing concepts for the fuselage section primary structure, elements were designed, fabricated, and structurally tested. These elements focused on key issues such as thick composite lugs and low cost forming of fastenerless, stiffener/moldline concepts. Manufacturing techniques included autoclave consideration, single diaphragm co-consolidation (SDCC), and roll-forming.

  15. Pragmatic Assessment of Request Speech Act of Iranian EFL Learners by Non-Native English Speaking Teachers

    ERIC Educational Resources Information Center

    Alemi, Minoo; Khanlarzadeh, Neda

    2016-01-01

    The analysis of raters' comments on pragmatic assessment of L2 learners is among new and understudied concepts in second language studies. To shed light on this issue, the present investigation targeted important variables such as raters' criteria and rating patterns by analyzing the interlanguage pragmatic assessment process of the Iranian…

  16. JPL Activated Carbon Treatment System (ACTS) for sewage

    NASA Technical Reports Server (NTRS)

    1976-01-01

    An Activated Carbon Treatment System (ACTS) was developed for sewage treatment and is being applied to a one-million gallon per day sewage treatment pilot plant in Orange County California. Activities reported include pyrolysis and activation of carbon-sewage sludge, and activated carbon treatment of sewage to meet ocean discharge standards. The ACTS Sewage treatment operations include carbon-sewage treatment, primary and secondary clarifiers, gravity (multi-media) filter, filter press dewatering, flash drying of carbon-sewage filter cake, and sludge pyrolysis and activation. Tests were conducted on a laboratory scale, 10,000 gallon per day demonstration plant and pilot test equipment. Preliminary economic studies are favorable to the ACTS process relative to activated sludge treatment for a 175,000,000 gallon per day sewage treatment plant.

  17. Spoken Language Activation Alters Subsequent Sign Language Activation in L2 Learners of American Sign Language

    ERIC Educational Resources Information Center

    Williams, Joshua T.; Newman, Sharlene D.

    2017-01-01

    A large body of literature has characterized unimodal monolingual and bilingual lexicons and how neighborhood density affects lexical access; however there have been relatively fewer studies that generalize these findings to bimodal (M2) second language (L2) learners of sign languages. The goal of the current study was to investigate parallel…

  18. The challenge of "teaching" large groups of learners: strategies to increase active participation and learning.

    PubMed

    Nierenberg, D W

    1998-01-01

    While teaching in a tutorial, seminar, or problem-based learning group format may be the most fun and most active/interactive for both learner and faculty mentor, there are situations in medical student education in which various constraints require the use of the "lecture" format. Similar constraints may occur in the field of continuing medical education, or graduate medical education, as well. When this occurs, the faculty mentor can increase the active participation of the learners in the audience by continuously stressing seven key pedagogical (androgogical) principles. These include: 1) begin the learning exercise with a clinical example or anecdote to show the relevance of the material to the student; 2) frequently ask the students whether they have ever seen examples of what you describe in their previous experience with patients, personal experience, experience with relatives, etc.; 3) ask students frequently whether they have heard similar material presented differently in other courses; 4) recruit students to help solve "mystery cases"; 5) show examples of similar material from real life (e.g., patient descriptions, or even excerpts from favorite TV shows); 6) ask students to help summarize key points at the end of the session; and 7) allow, or even encourage, whispering during the class. Using some or all of these techniques can help turn a "lecture format" into a much more fun, interactive, and valuable session that emphasizes "learning" rather than "teaching."

  19. Innovative Strategies for Empowering Your Students to Become Active, Responsible Learners

    NASA Astrophysics Data System (ADS)

    Hufnagel, B.

    2011-09-01

    The economy continues to sputter along, and the repercussions are now hitting hard at publicly-funded colleges and universities, with enrollment increasing and funding decreasing. Funding agencies are starting to look at retention and completion rates as a way to allocate scarce dollars. Improving these rates is also one way to increase the future stream of tuition; students who can't pass introductory classes like ASTRO101 won't enroll and pay tuition for the next level, and they won't complete their degree. So what can you, a mere professor of astronomy, do? Tired of the "What do you want me to know?" questions? Provide your students with learner-centered structures to help them learn more deeply. Do your students resist active-engagement techniques and hate group work? Share empowerment strategies for helping students become active, responsible learners who can thrive in a learner-centered environment. Do you think that it's wrong for the freshman classes to be over-crowded, yet your sophomore classes don't get enough students or don't even exist? After using the proven curriculum of On Course, college and universities across the country have improved their retention across a wide range of disciplines (http://www.OnCourseWorkshop.com/Data.htm). Experience a sample of the fun and engaging activities developed over two decades to help students (1) accept personal responsibility, (2) discover self motivation, (3) master self-management, (4) use interdependence, (5) gain self-awareness, (6) adopt lifelong learning, (7) develop emotional intelligence, and (8) believe in themselves. Since this is only a one-hour workshop, we will focus on choices one and four: to be successful, students need to see themselves as the primary cause of their outcomes and experiences and to build mutually supportive relationships in our classroom and labs. Outcomes: (1) one ASTRO101 Course-ready activity to help students accept personal responsibility; (2) one ASTRO101 Course

  20. 77 FR 16552 - Agency Information Collection Activities: JADE Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-21

    ..., Office of Management and Budget. Comments should be addressed to the OMB Desk Officer for U.S. Customs... SECURITY U.S. Customs and Border Protection Agency Information Collection Activities: JADE Act AGENCY: U.S. Customs and Border Protection, Department of Homeland Security. ACTION: 30-Day notice and request...

  1. Chinese High-School Students in Physics Classroom as Active, Self-Regulated Learners: Cognitive, Motivational and Environmental Aspects

    ERIC Educational Resources Information Center

    Neber, Heinz; He, Jing; Liu, Bang-Xiang; Schofield, Neville

    2008-01-01

    The present study investigates whether Chinese high-school students are self-regulated learners. A social-cognitive model that distinguishes environmental, motivational, and cognitive components of this active approach to learning is described. This provides an appropriate framework for investigating this complex issue with eighth and tenth…

  2. From Passive to Active Learners: The "Lived Experience" of Nurses in a Specialist Nephrology Nursing Education Programme

    ERIC Educational Resources Information Center

    Bridger, Jane

    2007-01-01

    Purpose: This study aims to explore the lived experience of learning for a group of staff nurses in the Middle East, who undertook a post-registration nursing education programme in the speciality of nephrology nursing (the NNP) between 2001 and 2002. The broad-based curriculum seeks to develop the staff nurses into active learners, able to…

  3. Identifying and Enhancing the Strengths of Gifted Learners, K-8: Easy-to-Use Activities and Lessons

    ERIC Educational Resources Information Center

    Maccagnano, Ann Marie

    2007-01-01

    Educators can identify children's strengths early on and gain insight into each student's unique abilities by using the numerous ideas and informal assessments in this exciting guide. Gifted and talented specialist Ann Maccagnano offers K-8 teachers challenging activities and engaging lessons to develop and nurture gifted learners' talents.…

  4. MAI (Multi-Dimensional Activity Based Integrated Approach): A Strategy for Cognitive Development of the Learners at the Elementary Stage

    ERIC Educational Resources Information Center

    Basantia, Tapan Kumar; Panda, B. N.; Sahoo, Dukhabandhu

    2012-01-01

    Cognitive development of the learners is the prime task of each and every stage of our school education and its importance especially in elementary state is quite worth mentioning. Present study investigated the effectiveness of a new and innovative strategy (i.e., MAI (multi-dimensional activity based integrated approach)) for the development of…

  5. Comparison of the Effects of Reflection and Contemplation Activities on Service-Learners' Cognitive and Affective Mindfulness

    ERIC Educational Resources Information Center

    Stewart, Trae; Alrutz, Megan

    2012-01-01

    This study investigates the extent to which service-learners' mindfulness is affected by engagement in reflection (e.g., dialogue) and contemplation activities (e.g., labyrinth tracing). The results are compared within and between treatment groups, while covarying for participants' initial levels of mindfulness. While both dialogue and…

  6. The Impact of Vocabulary Enhancement Activities on Vocabulary Acquisition and Retention among Male and Female EFL Learners in Iran

    ERIC Educational Resources Information Center

    Sharafi-Nejad, Maryam; Raftari, Shohreh; Bijami, Maryam; Khavari, Zahra; Ismail, Shaik Abdul Malik Mohamed; Eng, Lin Siew

    2014-01-01

    In general, incidental vocabulary acquisition is represented as the "picking up" of new vocabularies when students are engaged in a variety of reading, listening, speaking, or writing activities. Research has shown when learners read extensively incidental vocabulary acquisition happens. Many EFL students cannot be involved in reading…

  7. Grants Management Training Materials for Tribal Organizations Learner Manual Module 3: Federal Funding Accountability and Transparency Act (FFATA)

    EPA Pesticide Factsheets

    The Federal Funding Accountability and Transparency Act (FFATA) was signed on September 26, 2006. The intent is to empower every American with the ability to hold the government accountable for each spending decision.

  8. Using Web-Based Instruction to Promote Active Learning: Learners' Perspectives

    ERIC Educational Resources Information Center

    Lee, Lina

    2005-01-01

    This article reports classroom research on learners' perspectives on Web-based instruction that utilizes the "Blackboard" course management system. The Web-based instruction aims to provide and support collaborative learning while fostering learners' autonomy and accountability. The article also provides a description of the course…

  9. Elementary School EFL Learners' Vocabulary Learning: The Effects of Post-Reading Activities

    ERIC Educational Resources Information Center

    Atay, Derin; Kurt, Gokce

    2006-01-01

    As language learning involves the acquisition of thousands of words, teachers and learners alike would like to know how vocabulary learning can be fostered, especially in EFL settings where learners frequently acquire impoverished lexicons, despite years of formal study. Research indicates that reading is important but not sufficient for…

  10. Creative, Kinesthetic Activities to Motivate Young Learners to Communicate: A Conversation with Paula Garrett-Rucks

    ERIC Educational Resources Information Center

    Devall, Kelly Davidson

    2015-01-01

    This article presents a question and answer session in which Paula Garrett-Rucks discusses how creativity and kinesthetics motivate young language learners, the type of characteristics she might consider for different age groups in planning lessons, her views on the goals of world language teachers of young learners, and what a typical lesson…

  11. Investigative Research: How It Changes Learner Status.

    ERIC Educational Resources Information Center

    Kenny, Brian

    1993-01-01

    What matters about an educational activity is how learners respond to it. This article examines a program concerned with the learners' needs, through the expression of learners' own meanings, and advances the concept of investigative research as a suitable vehicle for more autonomous learning, through a change in learner status. (26 references)…

  12. Activity Catalog Tool (ACT) user manual, version 2.0

    NASA Technical Reports Server (NTRS)

    Segal, Leon D.; Andre, Anthony D.

    1994-01-01

    This report comprises the user manual for version 2.0 of the Activity Catalog Tool (ACT) software program, developed by Leon D. Segal and Anthony D. Andre in cooperation with NASA Ames Aerospace Human Factors Research Division, FLR branch. ACT is a software tool for recording and analyzing sequences of activity over time that runs on the Macintosh platform. It was designed as an aid for professionals who are interested in observing and understanding human behavior in field settings, or from video or audio recordings of the same. Specifically, the program is aimed at two primary areas of interest: human-machine interactions and interactions between humans. The program provides a means by which an observer can record an observed sequence of events, logging such parameters as frequency and duration of particular events. The program goes further by providing the user with a quantified description of the observed sequence, through application of a basic set of statistical routines, and enables merging and appending of several files and more extensive analysis of the resultant data.

  13. Activities for Challenging Gifted Learners by Increasing Complexity in the Common Core

    ERIC Educational Resources Information Center

    McKeone, Alyssa; Caruso, Lenora; Bettle, Kailyn; Chase, Ashley; Bryson, Bridget; Schneider, Jean S.; Rule, Audrey C.

    2015-01-01

    Gifted learners need opportunities for critical and creative thinking to stretch their minds and imaginations. Strategies for increasing complexity in the four core areas of language arts, mathematics, science, and social studies were addressed using the Common Core and Iowa Core Standards through several methods. Descriptive adjective object…

  14. Mathematics Learning with Multiple Solution Methods: Effects of Types of Solutions and Learners' Activity

    ERIC Educational Resources Information Center

    Große, Cornelia S.

    2014-01-01

    It is commonly suggested to mathematics teachers to present learners different methods in order to solve one problem. This so-called "learning with multiple solution methods" is also recommended from a psychological point of view. However, existing research leaves many questions unanswered, particularly concerning the effects of…

  15. Mediated Vocabulary in Native Speaker-Learner Interactions during an Oral Portfolio Activity

    ERIC Educational Resources Information Center

    Tocaimaza-Hatch, C. Cecilia

    2016-01-01

    This project investigated vocabulary learning from a sociocultural perspective--in particular, the way in which lexical knowledge was mediated in Spanish second language (L2) learners' and native speakers' (NSs') interactions. Nine students who were enrolled in an advanced conversation course completed an oral portfolio assignment consisting of…

  16. Impact of Consciousness-Raising Activities on Young English Language Learners' Grammar Performance

    ERIC Educational Resources Information Center

    Fatemipour, Hamidreza; Hemmati, Shiva

    2015-01-01

    Grammar Consciousness-Raising (GCR) is an approach to teaching of grammar which learners instead of being taught the given rules, experience language data. The data challenge them to rethink, restructure their existing mental grammar and construct an explicit rule to describe the grammatical feature which the data illustrate (Ellis, 2002). And…

  17. The effects of data-driven learning activities on EFL learners' writing development.

    PubMed

    Luo, Qinqin

    2016-01-01

    Data-driven learning has been proved as an effective approach in helping learners solve various writing problems such as correcting lexical or grammatical errors, improving the use of collocations and generating ideas in writing, etc. This article reports on an empirical study in which data-driven learning was accomplished with the assistance of the user-friendly BNCweb, and presents the evaluation of the outcome by comparing the effectiveness of BNCweb and a search engine Baidu which is most commonly used as reference resource by Chinese learners of English as a foreign language. The quantitative results about 48 Chinese college students revealed that the experimental group which used BNCweb performed significantly better in the post-test in terms of writing fluency and accuracy, as compared with the control group which used the search engine Baidu. However, no significant difference was found between the two groups in terms of writing complexity. The qualitative results about the interview revealed that learners generally showed a positive attitude toward the use of BNCweb but there were still some problems of using corpora in the writing process, thus the combined use of corpora and other types of reference resource was suggested as a possible way to counter the potential barriers for Chinese learners of English.

  18. Fostering Active Processing of Instructional Explanations of Learners with High and Low Prior Knowledge

    ERIC Educational Resources Information Center

    Acuna, Santiago R.; Garcia Rodicio, Hector; Sanchez, Emilio

    2011-01-01

    Despite the potential advantages of instructional explanations, evidence indicates that they are usually ineffective. Subsequent work has shown that in order to make instructional explanations effective indeed, one successful strategy is to combine them with indications of the limitations in learners' understanding that they are intended to…

  19. Developing Learners' Second Language Communicative Competence through Active Learning: Clickers or Communicative Approach?

    ERIC Educational Resources Information Center

    Agbatogun, Alaba Olaoluwakotansibe

    2014-01-01

    The purpose of this study was to compare the impact of clickers, the communicative approach and the lecture method on the communicative competence development of learners who were taught English a second language (ESL). Ninety nine pupils from three primary schools participated in the study. Quasi-experimental non-randomised pre-test posttest…

  20. Active Lessons for Active Brains: Teaching Boys and Other Experiential Learners, Grades 3-10

    ERIC Educational Resources Information Center

    James, Abigail Norfleet; Allison, Sandra Boyd; McKenzie, Caitlin Zimmerman

    2011-01-01

    If you're tired of repeating yourself to students who aren't listening, try a little less talk and a lot more action. The authors follow the best-selling "Teaching the Male Brain and Teaching the Female Brain" with this ready-to-use collection of mathematics, language arts, science, and classroom management strategies. Designed for active,…

  1. Mammalian intestinal alkaline phosphatase acts as highly active exopolyphosphatase.

    PubMed

    Lorenz, B; Schröder, H C

    2001-06-11

    Recent results revealed that inorganic polyphosphates (polyP), being energy-rich linear polymers of orthophosphate residues known from bacteria and yeast, also exist in higher eukaryotes. However, the enzymatic basis of their metabolism especially in mammalian cells is still uncertain. Here we demonstrate for the first time that alkaline phosphatase from calf intestine (CIAP) is able to cleave polyP molecules up to a chain length of about 800. The enzyme acts as an exopolyphosphatase degrading polyP in a processive manner. The pH optimum is in the alkaline range. Divalent cations are not required for catalytic activity but inhibit the degradation of polyP. The rate of hydrolysis of short-chain polyP by CIAP is comparable to that of the standard alkaline phosphatase (AP) substrate p-nitrophenyl phosphate. The specific activity of the enzyme decreases with increasing chain length of the polymer both in the alkaline and in the neutral pH range. The K(m) of the enzyme also decreases with increasing chain length. The mammalian tissue non-specific isoform of AP was not able to hydrolyze polyP under the conditions applied while the placental-type AP and the bacterial (Escherichia coli) AP displayed polyP-degrading activity.

  2. Autonomous Learner Model Resource Book

    ERIC Educational Resources Information Center

    Betts, George T.; Carey, Robin J.; Kapushion, Blanche M.

    2016-01-01

    "Autonomous Learner Model Resource Book" includes activities and strategies to support the development of autonomous learners. More than 40 activities are included, all geared to the emotional, social, cognitive, and physical development of students. Teachers may use these activities and strategies with the entire class, small groups, or…

  3. The Effect of English Language Learner Reclassification on Student ACT Scores, High School Graduation, and Postsecondary Enrollment: Regression Discontinuity Evidence from Wisconsin

    ERIC Educational Resources Information Center

    Carlson, Deven; Knowles, Jared E.

    2016-01-01

    The recent increase in the number of students classified as English language learners (ELLs) has focused significant attention on reclassification policy, which governs the process by which ELLs move toward, and are deemed to reach, full English proficiency. In this paper, we draw on a data set containing annual individual-level records for every…

  4. 78 FR 42103 - Agency Information Collection Activities: African Growth and Opportunity Act Certificate of Origin

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-15

    ... SECURITY U.S. Customs and Border Protection Agency Information Collection Activities: African Growth and... accordance with the Paperwork Reduction Act: African Growth and Opportunity Act Certificate of Origin (AGOA...: African Growth and Opportunity Act Certificate of Origin. OMB Number: 1651-0082. Form Number:...

  5. 75 FR 26974 - Agency Information Collection Activities: African Growth and Opportunity Act Certificate of Origin

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-13

    ... SECURITY Customs and Border Protection Agency Information Collection Activities: African Growth and... review and approval in accordance with the Paperwork Reduction Act: African Growth and Opportunity Act... forms of information. Title: African Growth and Opportunity Act Certificate of Origin. OMB Number:...

  6. Learner's Guide: Water Quality Monitoring. An Instructional Guide for the Two-Year Water Quality Monitoring Curriculum.

    ERIC Educational Resources Information Center

    Glazer, Richard B.; And Others

    This learner's guide is designed to meet the training needs for technicians involved in monitoring activities related to the Federal Water Pollution Act and the Safe Drinking Water Act. In addition it will assist technicians in learning how to perform process control laboratory procedures for drinking water and wastewater treatment plant…

  7. Using What Learners Know.

    ERIC Educational Resources Information Center

    Burns, Mary; Adams, Sharon

    2000-01-01

    This issue of "TAP into Learning" focuses on technology-assisted learning activities for students, in particular on those that use spreadsheets. Articles include: "Using What Learners Know"; "Activity: Grade 7 and 8 Math, Social Studies and Language Arts"; "Managing Growth: Collaborative Decision-Making in Urban Planning"; "Spreadsheets"; "Getting…

  8. Adult Learners' Week in Australia.

    ERIC Educational Resources Information Center

    Cross, John

    2002-01-01

    Promotional materials and activities for Australia's Adult Learners Week, which are shaped by a variety of stakeholders , include media strategies and a website. Activities are evaluated using a market research company and website and telephone hotline statistics. (SK)

  9. Communicative Language Teaching: The Learner's View.

    ERIC Educational Resources Information Center

    Nunan, David

    Several studies of the differences in teacher and learner perceptions of the usefulness of certain teaching techniques and activities reveal clear mismatches between learners' and teachers' views of language learning. The differences seem to be due to the sociocultural background and previous learning experiences of the learners and the influence…

  10. The Development and Evaluation of an Achievement Test for Measuring the Efficacy of Task-Based Writing Activities to Enhance Iranian EFL Learners' Reading Comprehension

    ERIC Educational Resources Information Center

    Nejad, Ferdows Mohsen; Khosravian, Fereshteh

    2014-01-01

    The present study examined the reliability of an achievement test to measure the efficacy of task-based writing activities to improve Iranian EFL learners' reading comprehension at the intermediate level in a private language institute in Ilam, Iran, namely Alefba language institute. To achieve the goal, the techniques for evaluating reliability…

  11. Effects of an Online Learning Community on Active and Reflective Learners' Learning Performance and Attitudes in a Face-to-Face Undergraduate Course

    ERIC Educational Resources Information Center

    Zhan, Zehui; Xu, Fuyin; Ye, Huiwen

    2011-01-01

    The purpose of this study was to examine the effects of an Online Learning Community (OLC) on active and reflective learners' learning performance and attitude in a face-to-face undergraduate digital design course. 814 freshmen in an introductory digital design course were randomly assigned to one of two treatments: one offered students an OLC,…

  12. Exploring Work-Based Foundation Skills in the ABLE Classroom. Instructional Activities and Resources for the Adult Learner [and] Supplemental Handouts for Modules. Version 1.2.

    ERIC Educational Resources Information Center

    Carman, Priscilla; Van Horn, Barbara; Hamilton, KayLynn; Williams, Mary Kay

    This guide contains activities and resources to help adult learners develop the work-based foundation skills and knowledge areas included on the Foundation Skills Framework wheel (Institute for the Study of Adult Literacy 2000). Its four sections (basic employability skills, basic workplace knowledge, basic workplace skills, and lifelong learning…

  13. The Effects of Pragmatic Consciousness-Raising Activities on the Development of Pragmatic Awareness and Use of Hearsay Evidential Markers for Learners of Japanese as a Foreign Language

    ERIC Educational Resources Information Center

    Narita, Ritsuko

    2009-01-01

    The present study investigates the effectiveness of pragmatic consciousness-raising (PCR) activities in the L2 pragmatic acquisition of hearsay evidential markers by learners of Japanese as a foreign language (JFL). PCR is essentially an inductive approach to facilitating awareness of how language forms are used appropriately in a given context.…

  14. The Effects of Pragmatic Consciousness-­-Raising Activities on the Learning of Speech Acts in the Beginning CFL Classroom

    ERIC Educational Resources Information Center

    Yang, Li; Zhu, Jia

    2016-01-01

    This study investigates the effects of instruction on learners' pragmatic competence by integrating pragmatic consciousness-raising (PCR) activities into a beginning-level Chinese language course during one academic semester. The study also examines the effect of integrating the PCR activities, i.e., before or after the instruction of a…

  15. "Dealing With" Unexpected Learner Contributions in Whole Group Activities: An Examination of Novice Language Teacher Discursive Practices

    ERIC Educational Resources Information Center

    Fagan, Drew S.

    2012-01-01

    The current paper examines the discursive practices of one novice English as a Second Language (ESL) teacher "dealing with" learners' unexpected contributions in whole group classroom interactions during teacher- and learner-initiated sequences-of-talk. The study draws from two fields of research: classroom discourse studies…

  16. Shopping [for] Power: How Adult Literacy Learners Negotiate the Marketplace

    ERIC Educational Resources Information Center

    Ozanne, Julie L.; Adkins, Natalie Ross; Sandlin, Jennifer A.

    2005-01-01

    Little empirical evidence exists on how adult literacy learners act as consumers. Yet, adult literacy programs often employ a "functional" approach to consumer education and assume that adult learners are deficient in consumer skills. Data from a qualitative study of the consumer behaviors of adult literacy learners are used to explore how adult…

  17. Reaching English Language Learners

    ERIC Educational Resources Information Center

    Keenan, Suzanne

    2004-01-01

    In the authors' science classroom, students who are English Language Learners (ELL) seem to struggle less than they do with other content areas. She believes the "handson" nature of science motivates and encourages students to interact with others. This interaction spurs conversation among the students involved in the activity. If a child is…

  18. Thinking Globally and Acting Locally: Environmental Education Teaching Activities.

    ERIC Educational Resources Information Center

    Mann, Lori D.; Stapp, William B.

    Provided are teaching activities related to: (1) food production and distribution; (2) energy; (3) transportation; (4) solid waste; (5) chemicals in the environment; (6) resource management; (7) pollution; (8) population; (9) world linkages; (10) endangered species; and (11) lifestyle and environment. The activities, designed to help learners…

  19. Exploring Shifts in Middle School Learners' Modeling Activity While Generating Drawings, Animations, and Computational Simulations of Molecular Diffusion

    NASA Astrophysics Data System (ADS)

    Wilkerson-Jerde, Michelle H.; Gravel, Brian E.; Macrander, Christopher A.

    2015-04-01

    Modeling and using technology are two practices of particular interest to K-12 science educators. These practices are inextricably linked among professionals, who engage in modeling activity with and across a variety of representational technologies. In this paper, we explore the practices of five sixth-grade girls as they generated models of smell diffusion using drawing, stop-motion animation, and computational simulation during a multi-day workshop. We analyze video, student discourse, and artifacts to address the questions: In what ways did learners' modeling practices, reasoning about mechanism, and ideas about smell shift as they worked across this variety of representational technologies? And, what supports enabled them to persist and progress in the modeling activity? We found that the girls engaged in two distinct modeling cycles that reflected persistence and deepening engagement in the task. In the first, messing about, they focused on describing and representing many ideas related to the spread of smell at once. In the second, digging in, they focused on testing and revising specific mechanisms that underlie smell diffusion. Upon deeper analysis, we found these cycles were linked to the girls' invention of "oogtom," a representational object that encapsulated many ideas from the first cycle and allowed the girls to restart modeling with the mechanistic focus required to construct simulations. We analyze the role of activity design, facilitation, and technological infrastructure in this pattern of engagement over the course of the workshop and discuss implications for future research, curriculum design, and classroom practice.

  20. Rehabilitation Services Administration Annual Report, Fiscal Year 2004: Report on Federal Activities under the "Rehabilitation Act"

    ERIC Educational Resources Information Center

    US Department of Education, 2007

    2007-01-01

    The "Rehabilitation Act of 1973," as amended (the act), provides the legislative basis for programs and activities that assist individuals with disabilities in the pursuit of gainful employment, independence, self-sufficiency and full integration into community life. This report is intended to provide a description of accomplishments and…

  1. 77 FR 13617 - Agency Information Collection Activities: Customs Modernization Act Recordkeeping Requirements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-07

    ... SECURITY U.S. Customs and Border Protection Agency Information Collection Activities: Customs Modernization Act Recordkeeping Requirements AGENCY: U.S. Customs and Border Protection (CBP), Department of... concerning the Customs Modernization Act Recordkeeping Requirements. This request for comment is being...

  2. 78 FR 15031 - Agency Information Collection Activities: Andean Trade Preferences Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-08

    ... SECURITY U.S. Customs and Border Protection Agency Information Collection Activities: Andean Trade Preferences Act AGENCY: U.S. Customs and Border Protection (CBP), Department of Homeland Security. ACTION: 60... Reduction Act of 1995 (Pub. L. 104-13; 44 U.S.C. 3505(c)(2)). DATES: Written comments should be received...

  3. 78 FR 26650 - Agency Information Collection Activities: African Growth and Opportunity Act Certificate of Origin

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-07

    ... SECURITY U.S. Customs and Border Protection Agency Information Collection Activities: African Growth and... comment on an information collection requirement concerning the African Growth and Opportunity Act...: Title: African Growth and Opportunity Act Certificate of Origin. OMB Number: 1651-0082. Form...

  4. 75 FR 9423 - Agency Information Collection Activities: African Growth and Opportunity Act Certificate of Origin

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-02

    ... SECURITY U.S. Customs and Border Protection Agency Information Collection Activities: African Growth and... requirement concerning the African Growth and Opportunity Act Certificate of Origin (AGOA). This request for...: Title: African Growth and Opportunity Act Certificate of Origin. OMB Number: 1651-0082. Form...

  5. [Modulators of the regulatory protein activity acting at microdoses].

    PubMed

    Iamskova, V P; Krasnov, M S; Skripnikova, V S; Moliavka, A A; Il'ina, A P; Margasiuk, D V; Borisenko, A V; Berezin, B B; Iamskov, I A

    2009-01-01

    New, previously not studied bioregulators active in the ultra low doses corresponding of 10(-8) - 10(-17) mg/ml have been isolated from vitreoretinal tissue of eye. It has been shown that these bioregulators comprise some regulatory peptides-modulators represented by proteins with molecular weights 15-70 KDa one of which is bovine serum albumin. Correlation between the nanosize of bioregulators and their ability to show activity in ultra low doses is established.

  6. Empowering Learners

    ERIC Educational Resources Information Center

    Franklin, Pat; Stephens, Claire Gatrell

    2010-01-01

    Turning students into lifelong learners is not easily accomplished. How do school librarians ensure that students have a zeal for learning? How do they encourage, cajole, or entice students to want to learn? The answer lies in empowering students with the skills they need to enjoy researching as well as reading for information and pleasure. This…

  7. 77 FR 12367 - Agency Information Collection and Reporting Activities; Electronic Filing of Bank Secrecy Act...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-29

    ... Financial Crimes Enforcement Network Agency Information Collection and Reporting Activities; Electronic Filing of Bank Secrecy Act (BSA) Reports; Final Notice AGENCY: Financial Crimes Enforcement Network (Fin..., Financial Crimes Enforcement Network. BILLING CODE 4810-02-P...

  8. Activity Based Learning as Self-Accessing Strategy to Promote Learners' Autonomy

    ERIC Educational Resources Information Center

    Ravi, R.; Xavier, P.

    2007-01-01

    The Activity Based Learning (ABL) is unique and effective to attract out-of -school children to schools. It facilitates readiness for learning, instruction, reinforcement and evaluation. ABL has transformed the classrooms into hubs of activities and meaningful learning. Activity-based learning, naturally leads to cooperative learning. Since group…

  9. Student Activities, Electronic Learners, and the Future: Integrating a Technological Component into Your Role as an Advisor.

    ERIC Educational Resources Information Center

    Simon, Jason Foster

    1996-01-01

    Provides advice to faculty advisers of student organizations on understanding the learning styles, needs, cultures, and strengths of today's "electronic learners." Advisers need to understand technology-related learning patterns and become technologically literate to work with college students. (MDM)

  10. Activators and repressors: A balancing act for X-inactivation.

    PubMed

    Goodrich, Leeanne; Panning, Barbara; Leung, Karen Nicole

    2016-08-01

    In early female embryos X-chromosome inactivation occurs concomitant with up regulation of the non-coding RNA, Xist, on the future inactive X-chromosome. Up regulation of Xist and coating of the future inactive X is sufficient to induce silencing. Therefore unlocking the mechanisms of X-chromosome inactivation requires thorough understanding of the transcriptional regulators, both activators and repressors, which control Xist. Mouse pluripotent embryonic stem cells, which have two active X chromosomes, provide a tractable ex vivo model system for studying X-chromosome inactivation, since this process is triggered by differentiation signals in these cultured cells. Yet there are significant discrepancies found between ex vivo analyses in mouse embryonic stem cells and in vivo studies of early embryos. In this review we elaborate on potential models of how Xist is up regulated on a single X chromosome in female cells and how ex vivo and in vivo analyses enlighten our understanding of the activators and repressors that control this non-coding RNA gene.

  11. The Structural Challenge: A Simple Design-Based Science Activity to Foster Creativity among Kinaesthetic Learners

    ERIC Educational Resources Information Center

    Amir, Nazir; Subramaniam, R.

    2014-01-01

    A suitable way for teachers to present science content and foster creativity in less academically inclined students is by getting them to engage in design-based science activities and guiding them along the way. This study illustrates how a design-and-make activity was carried out with the aim of getting students to showcase their creativity while…

  12. Hippocampus activity differentiates good from poor learners of a novel lexicon.

    PubMed

    Breitenstein, Caterina; Jansen, Andreas; Deppe, Michael; Foerster, Ann-Freya; Sommer, Jens; Wolbers, Thomas; Knecht, Stefan

    2005-04-15

    Language proficiency is a key to academic and workplace success for native and non-native speakers. It is largely unknown, however, why some people pick up languages more easily than others. We used event-related functional magnetic resonance imaging (e-fMRI) to elucidate which brain regions are modulated during the acquisition of a novel lexicon and which of these learning-related activity changes correlated with general semantic language knowledge. Fourteen healthy young subjects learned a novel vocabulary of 45 concrete nouns via an associative learning principle over the course of five blocks during e-fMRI. As a control condition, subjects took part in a structurally identical "No-Learning" condition lacking any learning principle. Overall, increasing vocabulary proficiency was associated with (intercorrelated) modulations of activity within the left hippocampus and the left fusiform gyrus, regions involved in the binding and integration of multimodal stimuli, and with an increasing activation of the left inferior parietal cortex, the presumed neural store of phonological associations. None of these activity changes were observed during the control condition. Furthermore, subjects who showed less suppression of hippocampal activity over learning blocks scored higher on semantic knowledge in their native language and learned the novel vocabulary more efficiently. Our findings indicate that (a) the successful acquisition of a new lexicon depends on correlated amplitude changes between the left hippocampus and neocortical regions and (b) learning-related hippocampus activity is a stable marker of individual differences in the ability to acquire and master vocabularies.

  13. Objects prompt authentic scientific activities among learners in a museum programme

    NASA Astrophysics Data System (ADS)

    Achiam, Marianne; Simony, Leonora; Kramer Lindow, Bent Erik

    2016-04-01

    Although the scientific disciplines conduct practical work in different ways, all consider practical work as the essential way of connecting objects and phenomena with ideas and the abstract. Accordingly, practical work is regarded as central to science education as well. We investigate a practical, object-based palaeontology programme at a natural history museum to identify how palaeontological objects prompt scientific activity among upper secondary school students. We first construct a theoretical framework based on an analysis of the programme's palaeontological content. From this, we build our reference model, which considers the specimens used in the programme, possible palaeontological interpretations of these specimens, and the conditions inherent in the programme. We use the reference model to analyse the activities of programme participants, and illustrate how these activities are palaeontologically authentic. Finally, we discuss our findings, examining the mechanism by which the specimens prompt scientific activities. We also discuss our discipline-based approach, and how it allows us to positively identify participants' activities as authentic. We conclude by discussing the implications of our findings.

  14. What's Your Problem? Working with Learners with Challenging Behaviour. Guidance for Colleges and Other Post-16 Education Providers on Implementing the Disability Discrimination Act

    ERIC Educational Resources Information Center

    Tissot, Cathy; Macqueen, Lynn; Faraday, Sally; Maudslay, Liz; Hewitson, Chris

    2007-01-01

    This report is one of a series of resources from the project, "The Disability Act: Taking the Work Forward 2003-05," managed by the Learning and Skills Network (LSN) in partnership with NIACE and Skill, supported by the Disability Rights Commission and funded by the Learning and Skills Council. The report is a follow-up to 1998's…

  15. Collaborative Syntactic Priming Activities and EFL Learners' Production of Wh-questions

    ERIC Educational Resources Information Center

    McDonough, Kim; Chaikitmongkol, Wanpen

    2010-01-01

    Syntactic priming is the tendency for a speaker to produce a structure that was encountered in recent discourse and is measured by calculating how frequently speakers use the modelled structures as opposed to alternatives. Recent lab-based studies have shown that carrying out syntactic priming activities with trained interlocutors positively…

  16. The Effect of Curricular Activities on Learner Autonomy: The Perspective of Undergraduate Mechanical Engineering Students

    ERIC Educational Resources Information Center

    Duarte, M.; Leite, C.; Mouraz, A.

    2016-01-01

    This study researches how first-year engineering students perceived the influence of curricular activities on their own learning autonomy, measured with an adaptation of the Personal Responsibility Orientation to Self-direction in Learning Scale (PRO-SDLS). Participants were questioned to assess the influence of the teacher's role. The results…

  17. Growing into Greatness: A Study of a Local History Group of Active-Retired Learners

    ERIC Educational Resources Information Center

    Corrigan, Trudy; Byrne, Brid; Harris, Phyllis; Lalor, Maureen; O'Connor, Maura; O'Reilly, Kathleen; Quinn, Frank; Forde, Kathleen

    2005-01-01

    Research in Canada on the learning needs of older people looked at such issues as how to cope with changes in society, the need to make a contribution and the need to be influential. The White Paper on Adult Education "Learning for Life" notes that strategies for active ageing stress the critical importance of access to learning as a key…

  18. Research on the Healthy Lifestyle Model, Active Ageing, and Loneliness of Senior Learners

    ERIC Educational Resources Information Center

    Hung, Jui-Ying; Lu, Kuo-Song

    2014-01-01

    Taiwan has the fastest ageing population in the world. Thus, the government and local policy makers need to formulate policies not just for the nursing and care needs of the aged. They also need to actively promote the need for lifelong learning among seniors in order to achieve elderly-friendly objectives, such as health promotion and delays in…

  19. The Effect of a Timed Reading Activity on EFL Learners: Speed, Comprehension, and Perceptions

    ERIC Educational Resources Information Center

    Chang, Anna C-S

    2010-01-01

    To develop reading fluency, a 13-week timed reading activity was integrated into a normal curriculum with the aim of improving students' reading rates. Participants were 84 college students divided into an experimental and a control group. The test instruments involved pretests and posttests on reading speed and comprehension. Students'…

  20. Tracking the silent epidemic and educating the public: CDC's traumatic brain injury-associated activities under the TBI Act of 1996 and the Children's Health Act of 2000.

    PubMed

    Langlois, Jean A; Marr, Angela; Mitchko, Jane; Johnson, Renee L

    2005-01-01

    The Traumatic Brain Injury Act of 1996 and the Children's Health Act of 2000 authorized the Centers for Disease Control and Prevention to conduct several activities associated with traumatic brain injury. This article describes how the Centers for Disease Control and Prevention responded to the legislation in 2 key areas: traumatic brain injury surveillance, and education and awareness.

  1. 45 CFR 90.3 - What programs or activities does the Age Discrimination Act of 1975 cover?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Discrimination Act of 1975 cover? 90.3 Section 90.3 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES... FINANCIAL ASSISTANCE General § 90.3 What programs or activities does the Age Discrimination Act of 1975 cover? (a) The Age Discrimination Act of 1975 applies to any program or activity receiving...

  2. Higher order thinking skills competencies required by outcomes-based education from learners.

    PubMed

    Chabeli, M M

    2006-08-01

    Outcomes-Based Education (OBE) brought about a significant paradigm shift in the education and training of learners in South Africa. OBE requires a shift from focusing on the teacher input (instruction offerings or syllabuses expressed in terms of content), to focusing on learner outcomes. OBE is moving away from 'transmission' models to constructivistic, learner-centered models that put emphasis on learning as an active process (Nieburh, 1996:30). Teachers act as facilitators and mediators of learning (Norms and Standards, Government Gazette vol 415, no 20844 of 2000). Facilitators are responsible to create the environment that is conducive for learners to construct their own knowledge, skills and values through interaction (Peters, 2000). The first critical cross-field outcome accepted by the South African Qualification Framework (SAQA) is that learners should be able to identify and solve problems by using critical and creative thinking skills. This paper seeks to explore some higher order thinking skills competencies required by OBE from learners such as critical thinking, reflective thinking, creative thinking, dialogic / dialectic thinking, decision making, problem solving and emotional intelligence and their implications in facilitating teaching and learning from the theoretical perspective. The philosophical underpinning of these higher order thinking skills is described to give direction to the study. It is recommended that a study focusing on the assessment of these intellectual concepts be made. The study may be qualitative, quantitative or mixed methods in nature (Creswell 2005).

  3. A review of the effects of long-acting progestogen-only contraceptives on ovarian activity.

    PubMed

    Li, X F; Davies, G C; Newton, J

    1992-03-01

    Progestogen-only contraception acts mainly by blocking cervical mucus and preventing sperm penetration through it does have a variable pattern of contraceptive effects on the endometrium and ovary. In contrast with the complete suppression of ovarian function with combined pill or injectable use, a variable degree of endocrine activity is demonstrated in women choosing a long-acting progestogen-only contraceptive. This degree of suppression of ovarian activity explains the decrease in systemic side-effects, the rapid resumption of ovulation and recovery of fertility following the discontinuation of the method. New delivery systems of progestogens, the vaginal ring and implant, offer better and more consistent contraceptive effects.

  4. Style Shifts among Japanese Learners before and after Study Abroad in Japan: Becoming Active Social Agents in Japanese

    ERIC Educational Resources Information Center

    Iwasaki, Noriko

    2010-01-01

    Previous studies on L2 Japanese sojourners often reported that learners overuse the plain style or haphazardly mix the plain and polite styles upon return. These styles, which are often associated with formal or informal contexts, also index complex social and situational meanings, and native speakers are reported to shift their styles to create…

  5. Teacher-Made Tactile Science Materials with Critical and Creative Thinking Activities for Learners Including Those with Visual Impairments

    ERIC Educational Resources Information Center

    Teske, Jolene K.; Gray, Phyllis; Kuhn, Mason A.; Clausen, Courtney K.; Smith, Latisha L.; Alsubia, Sukainah A.; Ghayoorad, Maryam; Rule, Audrey C.; Schneider, Jean Suchsland

    2014-01-01

    Gifted students with visual impairments are twice exceptional learners and may not evidence their advanced science aptitudes without appropriate accommodations for learning science. However, effective tactile science teaching materials may be easily made. Recent research has shown that when tactile materials are used with "all" students…

  6. Examining Student Cognitive and Affective Engagement and Reading Instructional Activities: Spanish-Speaking English Learners' Reading Profiles

    ERIC Educational Resources Information Center

    Barber, Ana Taboada; Gallagher, Melissa; Smith, Peet; Buehl, Michelle M.; Beck, Jori S.

    2016-01-01

    Recent research has emphasized the key role of engagement in helping students succeed in school and beyond. Given the academic struggles that many English learners (ELs) face as they transition to middle school, exploring the facets of engagement in middle school ELs is needed. We established reader profiles for eight sixth grade Hispanic ELs and…

  7. Guiding Learners to near Native Fluency in English through an Adaptive Programme of Activities Which Includes Phoneme and Prosody Analysis

    ERIC Educational Resources Information Center

    Lawson, Alistair; Attridge, Ann; Lapok, Paul

    2014-01-01

    Many students of English language find pronunciation difficult to master. This work in progress paper discusses an incremental and iterative approach towards developing requirements for software applications to assist learners with the perception and production of English pronunciation in terms of phonemes and prosody. It was found that prompts…

  8. Using Digital Storytelling as a Language Experience Approach Activity: Integrating English Language Learners into a Museum Field Trip

    ERIC Educational Resources Information Center

    Pappamihiel, N. Eleni; Knight, Jennifer Hatch

    2016-01-01

    Second language learners face countless obstacles in the classroom, including communication and comprehension limitations and difficulty building relationships with peers. Many teachers struggle to build an inclusive classroom environment and ensure all students, especially those with linguistic and other learning disadvantages, are learning. This…

  9. We Are What We Do: Examining Learner-Generated Content in the Anatomy Laboratory through the Lens of Activity Theory

    ERIC Educational Resources Information Center

    Doubleday, Alison F.; Wille, Sarah J.

    2014-01-01

    Video and photography are often used for delivering content within the anatomical sciences. However, instructors typically produce these resources to provide instructional or procedural information. Although the benefits of learner-generated content have been explored within educational research, virtually no studies have investigated the use of…

  10. Issues and Consequences for English Language Learners

    ERIC Educational Resources Information Center

    Abedi, Jamal

    2005-01-01

    A fair and valid assessment for every child, as mandated by legislation such as the No Child Left Behind Act (NCLB) of 2001 and the Improving America's School Act of 1994, must consider the complexity inherent in assessments for subgroups of students. Due to the rapid growth of the population of English language learners (ELLs) in the United…

  11. Learner Personas in CALL

    ERIC Educational Resources Information Center

    Heift, Trude

    2007-01-01

    In examining the titles of this year's conference presentations, the author noticed quite a few papers that focus on learner-specific issues, for instance, papers that address learning styles, learner needs, personality and learning, learner modeling and, more generally, pedagogical issues that deal with individual learner differences in…

  12. Learning from Learners.

    ERIC Educational Resources Information Center

    Matos, Joao Filipe

    This paper is a reflection of the preparation of the Psychology of Mathematics Education Panel (PME26) that discuss the issue of "learning from learners." What it implies to be a learner is formulated in order to reflect upon the way teachers and/or researchers learn from learners. The idea of conceptualizing the notion of "learning from learners"…

  13. 78 FR 38068 - Agency Information Collection Activities: United States-Caribbean Basin Trade Partnership Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-25

    ... SECURITY U.S. Customs and Border Protection Agency Information Collection Activities: United States-Caribbean Basin Trade Partnership Act AGENCY: U.S. Customs and Border Protection, Department of Homeland...: 1651-0083. SUMMARY: U.S. Customs and Border Protection (CBP) will be submitting the...

  14. 75 FR 15446 - Agency Information Collection Activities: United States-Caribbean Basin Trade Partnership Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-29

    ... SECURITY U.S. Customs And Border Protection Agency Information Collection Activities: United States- Caribbean Basin Trade Partnership Act AGENCY: U.S. Customs and Border Protection, Department of Homeland.... Customs and Border (CBP) invites the general public and other Federal agencies to comment on...

  15. 78 FR 23280 - Agency Information Collection Activities: United States-Caribbean Basin Trade Partnership Act...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-18

    ... SECURITY U.S. Customs and Border Protection Agency Information Collection Activities: United States-Caribbean Basin Trade Partnership Act (CBTPA) AGENCY: U.S. Customs and Border Protection (CBP), Department...: Direct all written comments to U.S. Customs and Border Protection, Attn: Tracey Denning, Regulations...

  16. 77 FR 27787 - Agency Information Collection Activities: Customs Modernization Act Recordkeeping Requirements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-11

    ... SECURITY U.S. Customs and Border Protection Agency Information Collection Activities: Customs Modernization Act Recordkeeping Requirements AGENCY: U.S. Customs and Border Protection, Department of Homeland.... SUMMARY: U.S. Customs and Border Protection (CBP) of the Department of Homeland Security will...

  17. A Review of CBO's Activities in 2008 under the Unfunded Mandates Reform Act. A CBO Report

    ERIC Educational Resources Information Center

    Lex, Leo

    2009-01-01

    In this report, part of an annual series that began in 1997, the Congressional Budget Office (CBO) reviews its activities under the Unfunded Mandates Reform Act of 1995. The report covers public laws enacted and legislation considered by the Congress in 2008 that would impose federal mandates on state, local, or tribal governments or on the…

  18. Assessment of MSFCs Process for the Development and Activation of Space Act Agreement

    NASA Technical Reports Server (NTRS)

    Daugherty, Rachel

    2014-01-01

    Space Act Agreements (SAAs) are contractual agreements that NASA utilizes to form partnerships with researchers, industry, and academia to stimulate cutting-edge innovation within the science and technology communities. center dot This study assessed the current SAA development and activation process at Marshall Space Flight Center (MSFC) to determine if improvements could be implemented to increase productivity, decrease time to activation, and improve the quality of deliverables.

  19. Pragmatics: Teaching Speech Acts

    ERIC Educational Resources Information Center

    Tatsuki, Donna H., Ed.; Houck, Noel R., Ed.

    2010-01-01

    Language teachers have long been aware of the devastating effect of learners' grammatically correct, yet situationally inappropriate spoken or written communication. This volume addresses how to raise learner awareness of pragmatic gaffs through research-based, field-tested activities such as composing e-mail requests, giving advice, making…

  20. An Iridium(III) Complex Inhibits JMJD2 Activities and Acts as a Potential Epigenetic Modulator.

    PubMed

    Liu, Li-Juan; Lu, Lihua; Zhong, Hai-Jing; He, Bingyong; Kwong, Daniel W J; Ma, Dik-Lung; Leung, Chung-Hang

    2015-08-27

    A novel iridium(III) complex was synthesized and evaluated for its ability to target JMJD2 enzymatic activity. The iridium(III) complex 1 can inhibit JMJD2 activity and was selective for JMJD2 activity over JARID, JMJD3, and HDAC activities. Moreover, 1 suppressed the trimethylation of the p21 promoter on H3K9me3 and interrupted the JMJD2D-H3K9me3 interactions in human cells, suggesting that it could act as an epigenetic modulator. To our knowledge, 1 represents the first metal-based JMJD2 inhibitor reported in the literature.

  1. Enhancing Writing Pedagogy with Learner Corpus Data

    ERIC Educational Resources Information Center

    Cotos, Elena

    2014-01-01

    Learner corpora have become prominent in language teaching and learning, enhancing data-driven learning (DDL) pedagogy by promoting "learning driven data" in the classroom. This study explores the potential of a local learner corpus by investigating the effects of two types of DDL activities, one relying on a native-speaker corpus (NSC)…

  2. 12 CFR 225.145 - Limitations established by the Competitive Equality Banking Act of 1987 on the activities and...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Equality Banking Act of 1987 on the activities and growth of nonbank banks. 225.145 Section 225.145 Banks... Companies Interpretations § 225.145 Limitations established by the Competitive Equality Banking Act of 1987... Competitive Equality Banking Act of 1987 (“CEBA”) redefined the term “bank” in the Bank Holding Company...

  3. 12 CFR 225.145 - Limitations established by the Competitive Equality Banking Act of 1987 on the activities and...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Equality Banking Act of 1987 on the activities and growth of nonbank banks. 225.145 Section 225.145 Banks... Companies Interpretations § 225.145 Limitations established by the Competitive Equality Banking Act of 1987... Competitive Equality Banking Act of 1987 (“CEBA”) redefined the term “bank” in the Bank Holding Company...

  4. The Tip of the Iceberg: Factors Affecting Learner Motivation

    ERIC Educational Resources Information Center

    Littlejohn, Andrew

    2008-01-01

    Teachers' informal discussions of learner motivation often emphasize the need to find ways to motivate learners, most usually through "fun" or "dynamic" activities. This paper starts from the assumption, however, that part of the work of the teacher is to avoid the "demotivation" of learners, and that there is a need to consider the overall…

  5. Seeing It Their Way: Learners and Language Curricula.

    ERIC Educational Resources Information Center

    Nunan, David

    The starting point for curriculum planning for second language instruction is the learner, and a curriculum can claim to be learner-centered only if key factors about the learner are made the basis for curriculum design at all stages in the planning and development of learning activities and materials and in the sequencing of learning experiences.…

  6. Implementation of the 2011 Therapeutic Activity Act: will commercialization improve the financial performance of Polish hospitals?

    PubMed

    Sagan, Anna; Sobczak, Alicja

    2014-11-01

    The Therapeutic Activity Act that came into force on 1 July 2011 was aimed at achieving a large-scale transformation of public hospitals into Commercial Code companies. The change of the legal form, from a public entity to a for-profit company, was expected to improve the poor economic efficiency of the public hospital sector. However, the mere change of the legal form does not guarantee a better financial performance of hospitals and thus the success of the Act. In many cases, deep internal changes are needed to achieve improvements in the financial performance of particular hospitals. In addition, a set of other measures at the national and regional levels, such as the mapping of health needs of the population, have to accompany the legal transformations in order to improve the efficiency of the hospital sector. The recent slowdown in the rate of the transformations is another factor that renders the success of the Act uncertain.

  7. ChIP-seq Mapping of Distant-Acting Enhancers and Their In Vivo Activities

    SciTech Connect

    Visel, Axel; Pennacchio, Len A.

    2011-06-01

    The genomic location and function of most distant-acting transcriptional enhancers in the human genome remains unknown We performed ChIP-seq for various transcriptional coactivator proteins (such as p300) directly from different embryonic mouse tissues, identifying thousands of binding sitesTransgenic mouse experiments show that p300 and other co-activator peaks are highly predictive of genomic location AND tissue-specific activity patterns of distant-acting enhancersMost enhancers are active only in one or very few tissues Genomic location of tissue-specific p300 peaks correlates with tissue-specific expression of nearby genes Most binding sites are conserved, but the global degree of conservation varies between tissues

  8. An active K/Ka-band antenna array for the NASA ACTS mobile terminal

    NASA Technical Reports Server (NTRS)

    Tulintseff, A.; Crist, R.; Densmore, Art; Sukamto, L.

    1993-01-01

    An active K/Ka-band antenna array is currently under development for NASA's ACTS Mobile Terminal (AMT). The AMT task will demonstrate voice, data, and video communications to and from the AMT vehicle in Los Angeles, California, and a base station in Cleveland, Ohio, via the ACTS satellite at 30 and 20 GHz. Satellite tracking for the land-mobile vehicular antenna system involves 'mechanical dithering' of the antenna, where the antenna radiates a fixed beam 46 deg. above the horizon. The antenna is to transmit horizontal polarization and receive vertical polarization at 29.634 plus or minus 0.15 GHz and 19.914 plus or minus 0.15 GHz, respectively. The active array will provide a minimum of 22 dBW EIRP transmit power density and a -8 dB/K deg. receive sensitivity.

  9. An active K/Ka-band antenna array for the NASA ACTS mobile terminal

    NASA Astrophysics Data System (ADS)

    Tulintseff, A.; Crist, R.; Densmore, Art; Sukamto, L.

    An active K/Ka-band antenna array is currently under development for NASA's ACTS Mobile Terminal (AMT). The AMT task will demonstrate voice, data, and video communications to and from the AMT vehicle in Los Angeles, California, and a base station in Cleveland, Ohio, via the ACTS satellite at 30 and 20 GHz. Satellite tracking for the land-mobile vehicular antenna system involves 'mechanical dithering' of the antenna, where the antenna radiates a fixed beam 46 deg. above the horizon. The antenna is to transmit horizontal polarization and receive vertical polarization at 29.634 plus or minus 0.15 GHz and 19.914 plus or minus 0.15 GHz, respectively. The active array will provide a minimum of 22 dBW EIRP transmit power density and a -8 dB/K deg. receive sensitivity.

  10. Expanded Perspectives on Autonomous Learners

    ERIC Educational Resources Information Center

    Oxford, Rebecca L.

    2015-01-01

    This paper explores two general perspectives on autonomous learners: psychological and sociocultural. These perspectives introduce a range of theoretically grounded facets of autonomous learners, facets such as the self-regulated learner, the emotionally intelligent learner, the self-determined learner, the mediated learner, the socioculturally…

  11. Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose–Efficacy Modeling

    PubMed Central

    Le Bihan, Amélie; Angulo-Barturen, Iñigo; Binkert, Christoph; Boss, Christoph; Brun, Reto; Brunner, Ralf; Buchmann, Stephan; Dechering, Koen J.; Delves, Michael; Ewerling, Sonja; Ferrer, Santiago; Fischli, Christoph; Gamo–Benito, Francisco Javier; Heidmann, Bibia; Jiménez-Díaz, María Belén; Leroy, Didier; Martínez, Maria Santos; Meyer, Solange; Moehrle, Joerg J.; Noviyanti, Rintis; Sanz, Laura María; Sauerwein, Robert W.; Scheurer, Christian; Schleiferboeck, Sarah; Sinden, Robert; Snyder, Christopher; Straimer, Judith; Wirjanata, Grennady; Marfurt, Jutta; Weller, Thomas; Clozel, Martine; Wittlin, Sergio

    2016-01-01

    Background Artemisinin resistance observed in Southeast Asia threatens the continued use of artemisinin-based combination therapy in endemic countries. Additionally, the diversity of chemical mode of action in the global portfolio of marketed antimalarials is extremely limited. Addressing the urgent need for the development of new antimalarials, a chemical class of potent antimalarial compounds with a novel mode of action was recently identified. Herein, the preclinical characterization of one of these compounds, ACT-451840, conducted in partnership with academic and industrial groups is presented. Method and Findings The properties of ACT-451840 are described, including its spectrum of activities against multiple life cycle stages of the human malaria parasite Plasmodium falciparum (asexual and sexual) and Plasmodium vivax (asexual) as well as oral in vivo efficacies in two murine malaria models that permit infection with the human and the rodent parasites P. falciparum and Plasmodium berghei, respectively. In vitro, ACT-451840 showed a 50% inhibition concentration of 0.4 nM (standard deviation [SD]: ± 0.0 nM) against the drug-sensitive P. falciparum NF54 strain. The 90% effective doses in the in vivo efficacy models were 3.7 mg/kg against P. falciparum (95% confidence interval: 3.3–4.9 mg/kg) and 13 mg/kg against P. berghei (95% confidence interval: 11–16 mg/kg). ACT-451840 potently prevented male gamete formation from the gametocyte stage with a 50% inhibition concentration of 5.89 nM (SD: ± 1.80 nM) and dose-dependently blocked oocyst development in the mosquito with a 50% inhibitory concentration of 30 nM (range: 23–39). The compound’s preclinical safety profile is presented and is in line with the published results of the first-in-man study in healthy male participants, in whom ACT-451840 was well tolerated. Pharmacokinetic/pharmacodynamic (PK/PD) modeling was applied using efficacy in the murine models (defined either as antimalarial activity or as

  12. 50 CFR 80.51 - What activities are eligible for funding under the Dingell-Johnson Sport Fish Restoration Act?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... under the Dingell-Johnson Sport Fish Restoration Act? 80.51 Section 80.51 Wildlife and Fisheries UNITED... SPORT FISH RESTORATION PROGRAM ADMINISTRATIVE REQUIREMENTS, PITTMAN-ROBERTSON WILDLIFE RESTORATION AND DINGELL-JOHNSON SPORT FISH RESTORATION ACTS Eligible Activities § 80.51 What activities are eligible...

  13. 12 CFR 225.145 - Limitations established by the Competitive Equality Banking Act of 1987 on the activities and...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Equality Banking Act of 1987 on the activities and growth of nonbank banks. 225.145 Section 225.145 Banks... Interpretations § 225.145 Limitations established by the Competitive Equality Banking Act of 1987 on the activities and growth of nonbank banks. (a) Introduction. Effective August 10, 1987, the Competitive...

  14. 50 CFR 80.51 - What activities are eligible for funding under the Dingell-Johnson Sport Fish Restoration Act?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... under the Dingell-Johnson Sport Fish Restoration Act? 80.51 Section 80.51 Wildlife and Fisheries UNITED... SPORT FISH RESTORATION PROGRAM ADMINISTRATIVE REQUIREMENTS, PITTMAN-ROBERTSON WILDLIFE RESTORATION AND DINGELL-JOHNSON SPORT FISH RESTORATION ACTS Eligible Activities § 80.51 What activities are eligible...

  15. 50 CFR 80.50 - What activities are eligible for funding under the Pittman-Robertson Wildlife Restoration Act?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... SPORT FISH RESTORATION PROGRAM ADMINISTRATIVE REQUIREMENTS, PITTMAN-ROBERTSON WILDLIFE RESTORATION AND DINGELL-JOHNSON SPORT FISH RESTORATION ACTS Eligible Activities § 80.50 What activities are eligible...

  16. Between the Social and the Selfish: Learner Autonomy in Online Environments

    ERIC Educational Resources Information Center

    Lewis, Tim

    2013-01-01

    This paper explores what it means to be an autonomous learner in an online social context. Using distinctions originally drawn by Jürgen Habermas, it argues that classic accounts of learner autonomy as teleological action are inadequate to explain learner activity in group settings. It points out that learners in such settings display attitudes…

  17. 29 CFR 516.30 - Learners, apprentices, messengers, students, or handicapped workers employed under special...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 3 2013-07-01 2013-07-01 false Learners, apprentices, messengers, students, or handicapped... the Act; Other Special Requirements § 516.30 Learners, apprentices, messengers, students, or... to persons employed as learners, apprentices, messengers or full-time students employed outside...

  18. 29 CFR 516.30 - Learners, apprentices, messengers, students, or handicapped workers employed under special...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 3 2012-07-01 2012-07-01 false Learners, apprentices, messengers, students, or handicapped... the Act; Other Special Requirements § 516.30 Learners, apprentices, messengers, students, or... to persons employed as learners, apprentices, messengers or full-time students employed outside...

  19. 29 CFR 516.30 - Learners, apprentices, messengers, students, or handicapped workers employed under special...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 3 2011-07-01 2011-07-01 false Learners, apprentices, messengers, students, or handicapped... the Act; Other Special Requirements § 516.30 Learners, apprentices, messengers, students, or... to persons employed as learners, apprentices, messengers or full-time students employed outside...

  20. 29 CFR 516.30 - Learners, apprentices, messengers, students, or handicapped workers employed under special...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 3 2014-07-01 2014-07-01 false Learners, apprentices, messengers, students, or handicapped... the Act; Other Special Requirements § 516.30 Learners, apprentices, messengers, students, or... to persons employed as learners, apprentices, messengers or full-time students employed outside...

  1. 29 CFR 516.30 - Learners, apprentices, messengers, students, or handicapped workers employed under special...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Learners, apprentices, messengers, students, or handicapped... the Act; Other Special Requirements § 516.30 Learners, apprentices, messengers, students, or... to persons employed as learners, apprentices, messengers or full-time students employed outside...

  2. Listening to Learners.

    ERIC Educational Resources Information Center

    Ravenhall, Mark

    This booklet looks at the role of learner feedback in the quality improvement process. It suggests how adult and community learning (ACL) providers can adapt and improve their practice to meet the needs of learners in the changed policy context. Chapter 1 explores why providers should listen to learners and finds that listening to learners…

  3. Learners' Interpretations of Recasts

    ERIC Educational Resources Information Center

    Carpenter, Helen; Jeon, K. Seon; MacGregor, David; Mackey, Alison

    2006-01-01

    A number of interaction researchers have claimed that recasts might be ambiguous to learners; that is, instead of perceiving recasts as containing corrective feedback, learners might see them simply as literal or semantic repetitions without any corrective element (Long, in press; Lyster & Ranta, 1997). This study investigates learners'…

  4. Learner and Faculty Support

    ERIC Educational Resources Information Center

    Guan, Sharon; Stanford, Daniel

    2016-01-01

    This chapter identifies effective ways to address learner and faculty support. It introduces methods for building a successful learner support system by providing sufficient resources and proactively addressing learner motivation. It also addresses effective faculty support through institutional policies, resources, training, and course…

  5. A brief review on anti diabetic plants: Global distribution, active ingredients, extraction techniques and acting mechanisms

    PubMed Central

    Chan, Chung-Hung; Ngoh, Gek-Cheng; Yusoff, Rozita

    2012-01-01

    A study has been conducted with the aim to provide researchers with general information on anti diabetic extracts based on relevant research articles collected from 34 reliable medical journals. The study showed that Asian and African continents have 56% and 17% share of the worldwide distribution of therapeutic herbal plants, respectively. In Asia, India and China are the leading countries in herbal plants research, and there has been an increase in medicinal research on plants extract for diabetes treatment since 1995 in these regions. The information collected shows that plant leaves are about 20% more favorable for storing active ingredients, as compared to other parts of herbal plants. A brief review on the extraction techniques for the mentioned parts is also included. Furthermore, the acting mechanisms for the anti diabetic activity were described, and the related active ingredients were identified. The findings reveal that most of the anti diabetic research is focused on the alteration of glucose metabolism to prevent diabetes. PMID:22654401

  6. 10 CFR 50.13 - Attacks and destructive acts by enemies of the United States; and defense activities.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Attacks and destructive acts by enemies of the United States; and defense activities. 50.13 Section 50.13 Energy NUCLEAR REGULATORY COMMISSION DOMESTIC... the effects of (a) attacks and destructive acts, including sabotage, directed against the facility...

  7. 10 CFR 50.13 - Attacks and destructive acts by enemies of the United States; and defense activities.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Attacks and destructive acts by enemies of the United States; and defense activities. 50.13 Section 50.13 Energy NUCLEAR REGULATORY COMMISSION DOMESTIC... the effects of (a) attacks and destructive acts, including sabotage, directed against the facility...

  8. 50 CFR 80.50 - What activities are eligible for funding under the Pittman-Robertson Wildlife Restoration Act?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... under the Pittman-Robertson Wildlife Restoration Act? 80.50 Section 80.50 Wildlife and Fisheries UNITED... SPORT FISH RESTORATION PROGRAM ADMINISTRATIVE REQUIREMENTS, PITTMAN-ROBERTSON WILDLIFE RESTORATION AND... funding under the Pittman-Robertson Wildlife Restoration Act? The following activities are eligible...

  9. 10 CFR 50.13 - Attacks and destructive acts by enemies of the United States; and defense activities.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Attacks and destructive acts by enemies of the United States; and defense activities. 50.13 Section 50.13 Energy NUCLEAR REGULATORY COMMISSION DOMESTIC... the effects of (a) attacks and destructive acts, including sabotage, directed against the facility...

  10. Learner Development in Language Learning.

    ERIC Educational Resources Information Center

    Wenden, Anita L.

    2002-01-01

    Focuses on learner development, a learner-centered innovation in foreign language-second language instruction that responds to learner diversity by aiming to improve the language learner's ability to learn a language. Describes various ideas that shaped early practice in learner development, and provides an evaluation of the theory and practice in…

  11. Modeling Learner Variability in CALL

    ERIC Educational Resources Information Center

    Heift, Trude

    2008-01-01

    This article describes challenges and benefits of modeling learner variability in Computer-Assisted Language Learning. We discuss the learner model of "E-Tutor," a learner model that addresses learner variability by focusing on certain aspects and/or features of the learner's interlanguage. Moreover, we introduce the concept of phrase descriptors,…

  12. Improving Learners' Research Process Skills

    NASA Astrophysics Data System (ADS)

    Quan, T. K.; Hunter, L.; Kluger-Bell, B.; Seagroves, S.

    2010-12-01

    The Professional Development Program (PDP) supports participants as they design inquiry activities that help learners improve their research process skills. These skills include the cognitive or reasoning skills that scientists and engineers use while doing research; for example, making a testable hypothesis, coordinating results from multiple experiments, or identifying and evaluating tradeoffs. Past work in the PDP indicated that additional support was needed to help participants design instructional activities that would teach these important skills. A new workshop was therefore developed for the 2009 PDP cycle, entitled "Improving Learners' Process Skills." In this workshop, participants worked in small groups to define specific science and engineering skills found in four past PDP activity designs. Participants distinguished between "simple tasks" and "authentic inquiry" activities that learners could perform as demonstration of the skill. Through this new workshop, participants were able to explicitly discuss ways in which individual process skills are unique or inter-related. In addition, by identifying a "simple task," participants were able to pinpoint areas in which their own designs could be improved to better focus on authentic inquiry tasks. In 2010, the workshop was slightly modified to help participants reconnect the research process skills with the activity content. In addition, the idea of using generic and context-specific scaffolds was also introduced. To make the participants feel like they were contributing to the PDP community, four activity designs actively being worked on in the 2010 cycle were used. Based on participant feedback, this "Improving Learners' Process Skills" workshop should be strongly considered for future returning participants.

  13. Integrative application of active controls (IAAC) technology to an advanced subsonic transport project. Initial act configuration design study

    NASA Technical Reports Server (NTRS)

    1980-01-01

    The performance and economic benefits of a constrained application of Active Controls Technology (ACT) are identified, and the approach to airplane design is established for subsequent steps leading to the development of a less constrained final ACT configuration. The active controls configurations are measured against a conventional baseline configuration, a state-of-the-art transport, to determine whether the performance and economic changes resulting from ACT merit proceeding with the project. The technology established by the conventional baseline configuration was held constant except for the addition of ACT. The wing, with the same planform, was moved forward on the initial ACT configuration to move the loading range aft relative to the wing mean aerodynamic chord. Wing trailing-edge surfaces and surface controls also were reconfigured for load alleviation and structural stabilization.

  14. Learner Agency

    ERIC Educational Resources Information Center

    Mick, Carola

    2011-01-01

    This article presents first results of an ethnographic research project in a Luxembourgish primary school that accompanied the development of a school project by children from the fifth grade. Analysing the data children themselves collected with Kodak Zi8 cameras in order to document their project activities, it investigates their possibilities…

  15. Integrated Application of Active Controls (IAAC) technology to an advanced subsonic transpot project-demonstration act system definition

    NASA Technical Reports Server (NTRS)

    Hanks, G. W.; Shomber, H. A.; Crumb, C. B.; Flora, C. C.; Macdonald, K. A. B.; Smith, R. D.; Sassi, A. P.; Dorwart, R. J.

    1982-01-01

    The 1985 ACT airplane is the Final Active Controls Technology (ACT) Airplane with the addition of three-axis fly by wire. Thus it retains all the efficiency features of the full ACT system plus the weight and cost savings accruing from deletion of the mechanical control system. The control system implements the full IAAC spectrum of active controls except flutter-mode control, judged essentially nonbeneficial, and incorporates new control surfaces called flaperons to make the most of wing-load alleviation. This redundant electronic system is conservatively designed to preserve the extreme reliability required of crucial short-period pitch augmentation, which provides more than half of the fuel savings.

  16. Phytochemicals increase the antibacterial activity of antibiotics by acting on a drug efflux pump

    PubMed Central

    Ohene-Agyei, Thelma; Mowla, Rumana; Rahman, Taufiq; Venter, Henrietta

    2014-01-01

    Drug efflux pumps confer resistance upon bacteria to a wide range of antibiotics from various classes. The expression of efflux pumps are also implicated in virulence and biofilm formation. Moreover, organisms can only acquire resistance in the presence of active drug efflux pumps. Therefore, efflux pump inhibitors (EPIs) are attractive compounds to reverse multidrug resistance and to prevent the development of resistance in clinically relevant bacterial pathogens. We investigated the potential of pure compounds isolated from plants to act as EPIs. In silico screening was used to predict the bioactivity of plant compounds and to compare that with the known EPI, phe-arg-β-naphthylamide (PAβN). Subsequently, promising products have been tested for their ability to inhibit efflux. Plumbagin nordihydroguaretic acid (NDGA) and to a lesser degree shikonin, acted as sensitizers of drug-resistant bacteria to currently used antibiotics and were able to inhibit the efflux pump-mediated removal of substrate from cells. We demonstrated the feasibility of in silico screening to identify compounds that potentiate the action of antibiotics against drug-resistant strains and which might be potentially useful lead compounds for an EPI discovery program. PMID:25224951

  17. Factor C acts as a lipopolysaccharide-responsive C3 convertase in horseshoe crab complement activation.

    PubMed

    Ariki, Shigeru; Takahara, Shusaku; Shibata, Toshio; Fukuoka, Takaaki; Ozaki, Aya; Endo, Yuichi; Fujita, Teizo; Koshiba, Takumi; Kawabata, Shun-ichiro

    2008-12-01

    The complement system in vertebrates plays an important role in host defense against and clearance of invading microbes, in which complement component C3 plays an essential role in the opsonization of pathogens, whereas the molecular mechanism underlying C3 activation in invertebrates remains unknown. In an effort to understand the molecular activation mechanism of invertebrate C3, we isolated and characterized an ortholog of C3 (designated TtC3) from the horseshoe crab Tachypleus tridentatus. Flow cytometric analysis using an Ab against TtC3 revealed that the horseshoe crab complement system opsonizes both Gram-negative and Gram-positive bacteria. Evaluation of the ability of various pathogen-associated molecular patterns to promote the proteolytic conversion of TtC3 to TtC3b in hemocyanin-depleted plasma indicated that LPS, but not zymosan, peptidoglycan, or laminarin, strongly induces this conversion, highlighting the selective response of the complement system to LPS stimulation. Although originally characterized as an LPS-sensitive initiator of hemolymph coagulation stored within hemocytes, we identified factor C in hemolymph plasma. An anti-factor C Ab inhibited various LPS-induced phenomena, including plasma amidase activity, the proteolytic activation of TtC3, and the deposition of TtC3b on the surface of Gram-negative bacteria. Moreover, activated factor C present on the surface of Gram-negative bacteria directly catalyzed the proteolytic conversion of the purified TtC3, thereby promoting TtC3b deposition. We conclude that factor C acts as an LPS-responsive C3 convertase on the surface of invading Gram-negative bacteria in the initial phase of horseshoe crab complement activation.

  18. The enduring role of the Emergency Medical Treatment and Active Labor Act.

    PubMed

    Rosenbaum, Sara

    2013-12-01

    The Emergency Medical Treatment and Active Labor Act (EMTALA) is a seminal law that imposes screening, stabilization, and transfer duties on all Medicare-participating hospitals that have emergency departments. More than twenty-five years after its enactment, EMTALA continues to generate controversy over the scope and depth of its obligations on issues ranging from the nature of the screening obligation and rules regarding on-call specialists to whether EMTALA's stabilization protections exclude emergency inpatients. Despite ongoing questions that flow from its detailed provisions, EMTALA is an enduring testament to society's evolving views that hospitals must provide emergency care not only to their established patients but to the broader communities they serve.

  19. Fly DPP10 acts as a channel ancillary subunit and possesses peptidase activity

    PubMed Central

    Shiina, Yohei; Muto, Tomohiro; Zhang, Zhili; Baihaqie, Ahmad; Yoshizawa, Takamasa; Lee, Hye-in J.; Park, Eulsoon; Tsukiji, Shinya; Takimoto, Koichi

    2016-01-01

    Mammalian DPP6 (DPPX) and DPP10 (DPPY) belong to a family of dipeptidyl peptidases, but lack enzyme activity. Instead, these proteins form complexes with voltage-gated K+ channels in Kv4 family to control their gating and other properties. Here, we find that the fly DPP10 ortholog acts as an ancillary subunit of Kv4 channels and digests peptides. Similarly to mammalian DPP10, the fly ortholog tightly binds to rat Kv4.3 protein. The association causes negative shifts in voltage dependence of channel activation and steady state inactivation. It also results in faster inactivation and recovery from inactivation. In addition to its channel regulatory role, fly DPP10 exhibits significant dipeptidyl peptidase activity with Gly-Pro-MCA (glycyl-L-proline 4-methylcoumaryl-7-amide) as a substrate. Heterologously expressed Flag-tagged fly DPP10 and human DPP4 show similar Km values towards this substrate. However, fly DPP10 exhibits approximately a 6-times-lower relative kcat value normalized with anti-Flag immunoreactivity than human DPP4. These results demonstrate that fly DPP10 is a dual functional protein, controlling Kv4 channel gating and removing bioactive peptides. PMID:27198182

  20. Motor activity affects adult skeletal muscle re-innervation acting via tyrosine kinase receptors.

    PubMed

    Sartini, Stefano; Bartolini, Fanny; Ambrogini, Patrizia; Betti, Michele; Ciuffoli, Stefano; Lattanzi, Davide; Di Palma, Michael; Cuppini, Riccardo

    2013-05-01

    Recently, muscle expression of brain-derived neurotrophic factor (BDNF) mRNA and protein under activity control has been reported. BDNF is a neurotrophin known to be involved in axon sprouting in the CNS. Hence, we set out to study the effect of chronic treadmill mid-intensity running on adult rat muscle re-innervation, and to explore the involvement of BDNF and tropomyosin-related kinase (Trk) receptors. After nerve crush, muscle re-innervation was evaluated using intracellular recordings, tension recordings, immunostaining and Western blot analyses. An enhanced muscle multiple innervation was found in running rats that was fully reversed to control values blocking Trk receptors or interrupting the running activity. An increase in muscle multiple innervation was also found in sedentary rats treated with a selective TrkB receptor agonist. The expression of TrkB receptors by intramuscular axons was demonstrated, and increased muscle expression of BDNF was found in running animals. The increase in muscle multiple innervation was consistent with the faster muscle re-innervation that we found in running animals. We conclude that, when regenerating axons contact muscle cells, muscle activity progressively increases modulating BDNF and possibly other growth factors, which in turn, acting via Trk receptors, induce axon sprouting to re-innervate skeletal muscle.

  1. Conceptualizing Learner Support Space.

    ERIC Educational Resources Information Center

    Cates, Ward Mitchell; Bruce, Ronald R.

    2000-01-01

    Discussion of computer-based online help systems for instructional software focuses on three types of learner support: for optimizing use of a computer program; for learning content; and for monitoring and enhancing learning. Proposes a multi-dimensional model of learner-support space defined by the intrusiveness of the delivery methods and…

  2. The Lifelong Learner.

    ERIC Educational Resources Information Center

    Gross, Ronald

    Designed to provide a general guide and stimuli for lifelong learning, this book examines all the positive factors of independent study. Lifelong learning is defined as self-directed growth free from the traditional schooling procedures. Chapters discuss the following: the lifelong learner; profiles of such learners in action; how to be…

  3. The Learner's Permit.

    ERIC Educational Resources Information Center

    Mayhew, Daniel R.

    2003-01-01

    Considers the role and value of an extended learner's period in a graduated driver-licensing system through a review of the literature. Concludes that further research is needed on the safety benefits and optional features of the learner period. (Contains 1 figure, 3 tables, and 41 references.) (AUTHOR/WFA)

  4. Focus on the Learner.

    ERIC Educational Resources Information Center

    Richards, Jack C.

    1988-01-01

    Ways in which curriculum development and methodology in teaching English as a Second Language can take account of learners are discussed. In addition, ways that teachers and researchers can collaborate in the process of developing a learner-center curriculum are examined. (28 references) (LB)

  5. Understanding Oral Learners

    ERIC Educational Resources Information Center

    Moon, W. Jay

    2012-01-01

    A five-year research project of seminary students from various cultural backgrounds revealed that the slight majority of contemporary seminary students studied are oral learners. Oral learners learn best and have their lives most transformed when professors utilize oral teaching and assessment methods. After explaining several preferences of oral…

  6. A Learner Centered Education.

    ERIC Educational Resources Information Center

    Ballard, Florence N.

    This paper proposes a learner-centered educational system, focusing on aspects that are intrinsically associated with the modern educational system, such as the curriculum, school community, parents, learners, and educational support personnel. It examines: primary level preparation (literacy, numeracy, and basic knowledge; examination and…

  7. Improving the EFL Learners' Speaking Ability through Interactive Storytelling

    ERIC Educational Resources Information Center

    Marzuki; Prayogo, Johannes Ananto; Wahyudi, Arwijati

    2016-01-01

    This present research was aimed to improve the EFL learners' speaking ability and their classroom activities through the implementation of Interactive Storytelling Strategy. Therefore, this study was directed to explore the beneficial of Interactive Storytelling that closely related to the EFL learners' everyday activities at their home and…

  8. Learner-Content-Interface as an Approach for Self-Reliant and Student-Centered Learning

    ERIC Educational Resources Information Center

    Nicolay, Robin; Schwennigcke, Bastian; Sahl, Sarah; Martens, Alke

    2015-01-01

    Conceptualization and implementation of computer supported teaching and training is currently not tailored to the paradigm of learner centration. Many technical solutions lack transparency and consistency regarding the supported learner activities. An insight into learners activities correlated to learning tasks is needed. In this paper we outline…

  9. 12 CFR 225.145 - Limitations established by the Competitive Equality Banking Act of 1987 on the activities and...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 3 2011-01-01 2011-01-01 false Limitations established by the Competitive Equality Banking Act of 1987 on the activities and growth of nonbank banks. 225.145 Section 225.145 Banks... activities and growth of nonbank banks. (a) Introduction. Effective August 10, 1987, the Competitive...

  10. Acting Atoms.

    ERIC Educational Resources Information Center

    Farin, Susan Archie

    1997-01-01

    Describes a fun game in which students act as electrons, protons, and neutrons. This activity is designed to help students develop a concrete understanding of the abstract concept of atomic structure. (DKM)

  11. Assessment of MSFCs Process for the Development and Activation of Space Act Agreements

    NASA Technical Reports Server (NTRS)

    Daugherty, Rachel A.

    2014-01-01

    A Space Act Agreement (SAA) is a contractual vehicle that NASA utilizes to form partnerships with non-NASA entities to stimulate cutting-edge innovation within the science and technology communities while concurrently supporting the NASA missions. SAAs are similar to traditional contracts in that they involve the commitment of Agency resources but allow more flexibility and are more cost effective to implement than traditional contracts. Consequently, the use of SAAs to develop partnerships has greatly increased over the past several years. To facilitate this influx of SAAs, Marshall Space Flight Center (MSFC) developed a process during a kaizen event to streamline and improve the quality of SAAs developed at the Center level. This study assessed the current SAA process to determine if improvements could be implemented to increase productivity, decrease time to activation, and improve the quality of deliverables. Using a combination of direct procedural observation, personnel interviews, and statistical analysis, elements of the process in need of remediation were identified and potential solutions developed. The findings focus primarily on the difficulties surrounding tracking and enforcing process adherence and communication issues among stakeholders. Potential solutions include utilizing customer relationship management (CRM) software to facilitate process coordination and co-locating or potentially merging the two separate organizations involved in SAA development and activation at MSFC.

  12. Drosophila myeloid leukemia factor acts with DREF to activate the JNK signaling pathway

    PubMed Central

    Yanai, H; Yoshioka, Y; Yoshida, H; Nakao, Y; Plessis, A; Yamaguchi, M

    2014-01-01

    Drosophila myelodysplasia/myeloid leukemia factor (dMLF), a homolog of human MLF1, oncogene was first identified by yeast two-hybrid screen using the DNA replication-related element-binding factor (DREF) as bait. DREF is a transcription factor that regulates proliferation-related genes in Drosophila. It is known that overexpression of dMLF in the wing imaginal discs through the engrailed-GAL4 driver causes an atrophied wing phenotype associated with the induction of apoptosis. However, the precise mechanisms involved have yet to be clarified. Here, we found the atrophied phenotype to be suppressed by loss-of-function mutation of Drosophila Jun N-terminal kinase (JNK), basket (bsk). Overexpression of dMLF induced ectopic JNK activation in the wing disc monitored with the puckered-lacZ reporter line, resulting in induction of apoptosis. The DREF-binding consensus DRE sequence could be shown to exist in the bsk promoter. Chromatin immunoprecipitation assays in S2 cells with anti-dMLF IgG and quantitative real-time PCR revealed that dMLF binds specifically to the bsk promoter region containing the DRE sequence. Furthermore, using a transient luciferase expression assay, we provide evidence that knockdown of dMLF reduced bsk gene promoter activity in S2 cells. Finally, we show that dMLF interacts with DREF in vivo. Altogether, these data indicate that dMLF acts with DREF to stimulate the bsk promoter and consequently activates the JNK pathway to promote apoptosis. PMID:24752236

  13. Role of gastrocnemius activation in knee joint biomechanics: gastrocnemius acts as an ACL antagonist.

    PubMed

    Adouni, M; Shirazi-Adl, A; Marouane, H

    2016-01-01

    Gastrocnemius is a premier muscle crossing the knee, but its role in knee biomechanics and on the anterior cruciate ligament (ACL) remains less clear when compared to hamstrings and quadriceps. The effect of changes in gastrocnemius force at late stance when it peaks on the knee joint response and ACL force was initially investigated using a lower extremity musculoskeletal model driven by gait kinematics-kinetics. The tibiofemoral joint under isolated isometric contraction of gastrocnemius was subsequently analyzed at different force levels and flexion angles (0°-90°). Changes in gastrocnemius force at late stance markedly influenced hamstrings forces. Gastrocnemius acted as ACL antagonist by substantially increasing its force. Simulations under isolated contraction of gastrocnemius confirmed this role at all flexion angles, in particular, at extreme knee flexion angles (0° and 90°). Constraint on varus/valgus rotations substantially decreased this effect. Although hamstrings and gastrocnemius are both knee joint flexors, they play opposite roles in respectively protecting or loading ACL. Although the quadriceps is also recognized as antagonist of ACL, at larger joint flexion and in contrast to quadriceps, activity in gastrocnemius substantially increased ACL forces (anteromedial bundle). The fact that gastrocnemius is an antagonist of ACL should help in effective prevention and management of ACL injuries.

  14. Self-assembled gold nanocrystal micelles act as an excellent artificial nanozyme with ribonuclease activity.

    PubMed

    Zhang, Zhiming; Fu, Qiuan; Li, Xiangqiu; Huang, Xin; Xu, Jiayun; Shen, Jiacong; Liu, Junqiu

    2009-06-01

    Water-soluble Au nanocrystal (NC) micelles with an inserted catalytic Cu(II) center that act as excellent nanoenzyme models for imitating ribonuclease were constructed by supramolecular self-assembly. The dodecane-1-thiol-based Au NC was constructed first, and subsequently the cationic surfactant hexadecyltrimethylammonium bromide and the catalytic ligand (N1,N1-bis(2-aminoethyl)-N2-dodecylethane-1,2-diamine) copper(II) were installed on the surface of the Au NC via hydrophobic interaction. The catalytic capability of the Au NC micelles designed was estimated by the cleavage of a typical RNA analogue, 2-hydroxypropyl p-nitrophenyl phosphate (HPNP). The study of the catalytic behavior of Au NC micelle catalysis showed that the Au NC micelles exhibited dramatic ribonuclease-like activity: a high rate acceleration of k(cat)/k(uncat) = 1.10 x 10(5) for the cleavage of HPNP in comparison with the spontaneous cleavage of HPNP (k(uncat)) was observed. The catalytic capability for HPNP cleavage by these functionalized Au NC micelles can be compared with that of covalent Au nanoparticles reported previously as nanozymes under comparable conditions. A detailed investigation of enzymatic kinetics was carried out and a possible mechanism was suggested.

  15. Beyond Beginning Learners.

    ERIC Educational Resources Information Center

    Jongsma, Kathy

    2003-01-01

    Discusses materials for middle grade and high school learners. Explains useful resources for teaching struggling writers. Details a publishing tool, a reading comprehension assessment, and a Scholastic Assessment Tests (SAT) preparation text. (PM)

  16. Independence Pending: Teacher Behaviors Preceding Learner Problem Solving

    ERIC Educational Resources Information Center

    Roesler, Rebecca A.

    2017-01-01

    The purposes of the present study were to identify the teacher behaviors that preceded learners' active participation in solving musical and technical problems and describe learners' roles in the problem-solving process. I applied an original model of problem solving to describe the behaviors of teachers and students in 161 rehearsal frames…

  17. Supporting Learners' Appropriation of a Web-Based Learning Curriculum

    ERIC Educational Resources Information Center

    Rasseneur-Coffinet, Dorothée; Smyrniou, Georgia; Tchounikine, Pierre

    2007-01-01

    This article presents an approach and tools that can help learners appropriate a Web-based learning curriculum and become active participants in their learning. The approach is based on a detailed modeling of the curriculum and intends to equip the learners with different computer-based tools facilitating a multiple point of view perception of the…

  18. Practices and Prospects of Learner Autonomy: Teachers' Perceptions

    ERIC Educational Resources Information Center

    Al Asmari, AbdulRahman

    2013-01-01

    Language learning process works through the learners' own reflection on how they learn and it makes learners active in the sense that they learn to analyze their learning strategies. So they start making decisions, e.g., whether to improve them or not, and in which way. Generally, this trait is missing in traditional language teaching process and…

  19. Annotation-Based Learner's Personality Modeling in Distance Learning Context

    ERIC Educational Resources Information Center

    Omheni, Nizar; Kalboussi, Anis; Mazhoud, Omar; Kacem, Ahmed Hadj

    2016-01-01

    Researchers in distance education are interested in observing and modeling learners' personality profiles, and adapting their learning experiences accordingly. When learners read and interact with their reading materials, they do unselfconscious activities like annotation which may be key feature of their personalities. Annotation activity…

  20. Maximising Asian ESL Learners' Communicative Oral English via Drama

    ERIC Educational Resources Information Center

    Gill, Chamkaur

    2016-01-01

    This paper proposes that activities based on a variety of drama-based techniques could be valuable in giving Asian ESL learners opportunities to use communicative spoken English confidently and without restraint during their time in English-language-speaking countries. These learners often get anxious when in situations where they are required to…

  1. Factors Driving Learner Success in Online Professional Development

    ERIC Educational Resources Information Center

    Vu, Phu; Cao, Vien; Vu, Lan; Cepero, Jude

    2014-01-01

    This study examined factors that contributed to the success of online learners in an online professional development course. Research instruments included an online survey and learners' activity logs in an online professional development course for 512 in-service teachers. The findings showed that there were several factors affecting online…

  2. Exploring Shifts in Middle School Learners' Modeling Activity While Generating Drawings, Animations, and Computational Simulations of Molecular Diffusion

    ERIC Educational Resources Information Center

    Wilkerson-Jerde, Michelle H.; Gravel, Brian E.; Macrander, Christopher A.

    2015-01-01

    Modeling and using technology are two practices of particular interest to K-12 science educators. These practices are inextricably linked among professionals, who engage in modeling activity with and across a variety of representational technologies. In this paper, we explore the practices of five sixth-grade girls as they generated models of…

  3. Design Issues Related to the Evaluation of Learner--Computer Interaction in a Web-Based Environment: Activities v. Tasks

    ERIC Educational Resources Information Center

    Hemard, Dominique

    2006-01-01

    If web-based technology is increasingly becoming the central plank of contemporary teaching and learning processes, there is still too little evidence to suggest that it is delivering purposeful learning activities beyond its widely perceived potential as a learning resource providing content and learning objects. This is due in part to the…

  4. Language-Building Activities and Interaction Variations with Mixed-Ability ESL University Learners in a Content-Based Course

    ERIC Educational Resources Information Center

    Serna Dimas, Héctor Manuel; Ruíz Castellanos, Erika

    2014-01-01

    The preparation of both language-building activities and a variety of teacher/student interaction patterns increase both oral language participation and content learning in a course of manual therapy with mixed-language ability students. In this article, the researchers describe their collaboration in a content-based course in English with English…

  5. Community Resources. Teacher Guidebook and Student Activity Book. Adult Basic Education Project REAL: Relevant Education for Adult Learners.

    ERIC Educational Resources Information Center

    Edgar, S. Keith

    This packet contains both a teacher's guide and a student activity book designed to help adult students locate and use community resources. Both booklets cover the following topics: the public library, Social Security, postal services, use of the telephone and the telephone directory, the newspaper, the Cooperative Extension Service, reference…

  6. You Can Be in a Group and Still Not Cooperate. Collaborative Approaches and Cooperative Learning Activities for Adult Learners.

    ERIC Educational Resources Information Center

    Parma City School District, OH.

    This handbook defines and describes the benefits of both collaborative approaches and cooperative techniques. An introduction uses watercolor marbling as a metaphor for collaborative approaches and cooperative activities. Section I provides research results regarding problems of adult literacy programs, skills employers want, and Bloom's taxonomy.…

  7. Exploring South African Grade 11 Learners' Perceptions of Classroom Inquiry: Validation of a Research Instrument

    ERIC Educational Resources Information Center

    Dudu, Washington T.; Vhurumuku, Elaosi

    2012-01-01

    This paper discusses the adoption and validation of a research instrument, on determining learners' levels of perception of classroom inquiry based on data collected from South African Grade 11 learners. The Learners' Perception of Classroom Inquiry (LPCI) instrument consists only of Likert-type items which rank activities according to how often…

  8. The Effect of Reading on Second-Language Learners' Production in Tasks

    ERIC Educational Resources Information Center

    Collentine, Karina

    2016-01-01

    Tasks provide engaging ways to involve learners in meaningful, real-world activities with the foreign language (FL). Yet selecting classroom tasks suitable to learners' linguistic readiness is challenging, and task-based research is exploring the relationship between learners' overall abilities (e.g., reading, grammatical) and the complexity and…

  9. Comparing Learner Community Behavior in Multiple Presentations of a Massive Open Online Course

    ERIC Educational Resources Information Center

    Gallagher, Silvia Elena; Savage, Timothy

    2016-01-01

    Massive Online Open Courses (MOOCs) can create large scale communities of learners who collaborate, interact and discuss learning materials and activities. MOOCs are often delivered multiple times with similar content to different cohorts of learners. However, research into the differences of learner communication, behavior and expectation between…

  10. Comparing Learner Community Behavior in Multiple Presentations of a Massive Open Online Course

    ERIC Educational Resources Information Center

    Gallagher, Silvia Elena; Savage, Timothy

    2015-01-01

    Massive Online Open Courses (MOOCs) can create large scale communities of learners who collaborate, interact and discuss learning materials and activities. MOOCs are often delivered multiple times with similar content to different cohorts of learners. However, research into the differences of learner communication, behavior and expectation between…

  11. 50 CFR 80.50 - What activities are eligible for funding under the Pittman-Robertson Wildlife Restoration Act?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 9 2014-10-01 2014-10-01 false What activities are eligible for funding under the Pittman-Robertson Wildlife Restoration Act? 80.50 Section 80.50 Wildlife and Fisheries UNITED...) Obtain data to guide and direct the regulation of hunting. (4) Acquire real property suitable or...

  12. Integrated Application of Active Controls (IAAC) technology to an advanced subsonic transport project: Final ACT configuration evaluation

    NASA Technical Reports Server (NTRS)

    1982-01-01

    The Final ACT Configuration Evaluation Task of the Integrated Application of Active Controls (IAAC) technology project within the energy efficient transport program is summarized. The Final ACT Configuration, through application of Active Controls Technology (ACT) in combination with increased wing span, exhibits significant performance improvements over the conventional baseline configuration. At the design range for these configurations, 3590 km, the block fuel used is 10% less for the Final ACT Configuration, with significant reductions in fuel usage at all operational ranges. Results of this improved fuel usage and additional system and airframe costs and the complexity required to achieve it were analyzed to determine its economic effects. For a 926 km mission, the incremental return on investment is nearly 25% at 1980 fuel prices. For longer range missions or increased fuel prices, the return is greater. The technical risks encountered in the Final ACT Configuration design and the research and development effort required to reduce these risks to levels acceptable for commercial airplane design are identified.

  13. Do ePortfolios Contribute to Learners' Reflective Thinking Activities? : A Preliminary Study of Nursing Staff Users.

    PubMed

    Tzeng, Wen-Sheng; Kuo, Kuang-Ming; Talley, Paul C; Chen, Hsiu-Chin; Wang, Jhi-Joung

    2015-09-01

    The purposes of this study are threefold: 1) to find out what characteristics are required for the successful use of ePortfolios; 2) to discover what activities best represent reflective thinking during the use of ePortfolios; and, 3) to investigate the interrelationship between nursing staff users' perceived success levels with ePortfolios and with their reflective thinking activities. Survey methodology was used to gather responses from 78 nurses from a medical center located in southern Taiwan via questionnaires. Factor analysis and canonical correlation analysis were used to analyze the collected data. The results demonstrated that system quality, information quality, and user satisfaction are important variables in successful ePortfolio usage; while habitual action, understanding, reflection, and critical reflection are major variables of reflective thinking. Further, we found a significant relationship exists between the relative success of ePortfolios and reflective thinking activities of ePortfolios users. The subject hospital should pay special attention to important characteristics including system quality, information quality, and user satisfaction when employing ePortfolios to help nursing staff users to achieve their learning goals through this form of reflective thinking.

  14. Comparative effects of long-acting and short-acting loop diuretics on cardiac sympathetic nerve activity in patients with chronic heart failure

    PubMed Central

    Matsuo, Yae; Kasama, Shu; Toyama, Takuji; Funada, Ryuichi; Takama, Noriaki; Koitabashi, Norimichi; Ichikawa, Shuichi; Suzuki, Yasuyuki; Matsumoto, Naoya; Sato, Yuichi; Kurabayashi, Masahiko

    2016-01-01

    Objective Short-acting loop diuretics are known to enhance cardiac sympathetic nerve activity (CSNA) in patients with chronic heart failure (CHF). The effects of two loop diuretics—long-acting azosemide and short-acting furosemide—on CSNA were evaluated using 123I-metaiodobenzylguanidine (MIBG) scintigraphy in patients with CHF. Methods The present study was a subanalysis of our previously published study, which had reported that serial 123I-MIBG studies were the most useful prognostic indicator in patients with CHF. Patients with CHF (n=208, left ventricular ejection fraction <45%) but no history of cardiac events for at least 5 months prior to the study were identified according to their histories of acute decompensated heart failure requiring hospitalisation. Patients underwent 123I-MIBG scintigraphy immediately before hospital discharge and at a 6-month follow-up. The delayed % denervation, delayed heart/mediastinum count (H/M) ratio and washout rate (WR) were determined using 123I-MIBG scintigraphy. A total of 108 patients were selected, and propensity score matching was used to compare patients treated with either oral azosemide (n=54) or furosemide (n=54). Results After treatment, 123I-MIBG scintigraphic parameters improved in both groups. However, the degree of change in % denervation was −13.8±10.5 in the azosemide group and −5.7±12.7 in the furosemide group (p<0.01), the change in H/M ratio was 0.20±0.16 in the azosemide group and 0.06±0.19 in the furosemide group (p<0.01), and the change in WR was −11.3±9.2% in the azosemide group and −3.0±12.7% in the furosemide group (p<0.01). Moreover, multivariate analysis showed an independent and significant positive relationship between furosemide and δ-WR from hospital discharge to 6 months after treatment in patients with CHF (p=0.001). Conclusions These findings indicate that azosemide suppresses CSNA compared with furosemide in patients with CHF. Trial registration number UMIN000000626

  15. Measuring Parental Support for Children’s Physical Activity in White and African American Parents: The Activity Support Scale for Multiple Groups (ACTS-MG)

    PubMed Central

    Davison, Kirsten K.; Li, Kaigang; Baskin, Monica L.; Cox, Tiffany; Affuso, Olivia

    2010-01-01

    Objectives The Activity Support Scale (ACTS) was expanded for use with African American families. Its factorial invariance and internal reliability were examined for non-Hispanic white and African American parents. Methods The ACTS was modified to improve its applicability to African American families based on information from five focus groups with 27 African American parents of elementary school-aged children. Between 2006 and 2008, the revised scale was administered to 119 African American and 117 non-Hispanic white parents in northeastern NY and Alabama. Its factorial invariance across race/ethnicity and internal consistency were examined. Results Factor analysis of the revised scale, the Activity Support Scale for Multiple Groups (ACTS-MG), identified four parenting factors in white and African American parents including logistic support, modeling, use of community resources to promote physical activity (PA), and restriction of sedentary behaviors. Results supported the scale’s internal reliability and factorial invariance across race/ethnicity. Conclusion The ACTS-MG is appropriate for use with non-Hispanic white and African American families and will enable the extension of current research with white families to the examination of strategies supporting PA in African American families. Additional psychometric work with the ACTS-MG is encouraged. PMID:21111755

  16. Integrated Application of Active Controls (IAAC) technology to an advanced subsonic transport project: Test act system validation

    NASA Technical Reports Server (NTRS)

    1985-01-01

    The primary objective of the Test Active Control Technology (ACT) System laboratory tests was to verify and validate the system concept, hardware, and software. The initial lab tests were open loop hardware tests of the Test ACT System as designed and built. During the course of the testing, minor problems were uncovered and corrected. Major software tests were run. The initial software testing was also open loop. These tests examined pitch control laws, wing load alleviation, signal selection/fault detection (SSFD), and output management. The Test ACT System was modified to interface with the direct drive valve (DDV) modules. The initial testing identified problem areas with DDV nonlinearities, valve friction induced limit cycling, DDV control loop instability, and channel command mismatch. The other DDV issue investigated was the ability to detect and isolate failures. Some simple schemes for failure detection were tested but were not completely satisfactory. The Test ACT System architecture continues to appear promising for ACT/FBW applications in systems that must be immune to worst case generic digital faults, and be able to tolerate two sequential nongeneric faults with no reduction in performance. The challenge in such an implementation would be to keep the analog element sufficiently simple to achieve the necessary reliability.

  17. Is WIOA Good for Adult Learners? A Response to Amy Pickard's Forum Essay

    ERIC Educational Resources Information Center

    Bragg, Debra D.

    2016-01-01

    According to Debra Bragg, Amy Pickard's article "WIOA: Implications for Low-Scoring Adult Learners" (EJ1125478) offers a provocative analysis of the federal Workforce Innovation and Opportunity Act (WIOA) that is important for any educator to read, especially educators who work with adult learners in postsecondary education. Pickard's…

  18. "I'm Not Agree with You." ESL Learners' Expressions of Disagreement

    ERIC Educational Resources Information Center

    Kreutel, Karen

    2007-01-01

    In recent years, increasing emphasis has been put on pragmatic competence as part of foreign language curricula. This article analyzes the devices used by learners of English as a Second Language (ESL) in order to perform the "speech act of disagreement" in their L2. Data from 27 ESL learners were gathered by means of Discourse…

  19. Instructional Practices That Promote Reading Proficiency for English Language Learners in Grades 3 and 5

    ERIC Educational Resources Information Center

    Smiley-Blanton, Regina

    2010-01-01

    The No Child Left Behind Act (NCLB) requires that all public school students, including English language learners, achieve proficiency in reading, math, and science by 2014 as measured on state assessments. English language learners enrolled in public schools for the first time receive a 1-year deferment from these state assessments in subjects…

  20. EGameFlow: A Scale to Measure Learners' Enjoyment of E-Learning Games

    ERIC Educational Resources Information Center

    Fu, Fong-Ling; Su, Rong-Chang; Yu, Sheng-Chin

    2009-01-01

    In an effective e-learning game, the learner's enjoyment acts as a catalyst to encourage his/her learning initiative. Therefore, the availability of a scale that effectively measures the enjoyment offered by e-learning games assist the game designer to understanding the strength and flaw of the game efficiently from the learner's points of view.…

  1. Pragmatic Development of Chinese EFL Learners--A Study on FL Suggestions

    ERIC Educational Resources Information Center

    Gu, Tongqing

    2014-01-01

    While the number of studies on the pragmatic development of nonnative English speakers has been increasing, surprisingly little research has been conducted on the development of the ability of foreign language learners to perform the suggestion speech act, with even less taking Chinese EFL learners as the target group. The present study examines…

  2. A Novel Method for Learner Assessment Based on Learner Annotations

    ERIC Educational Resources Information Center

    Noorbehbahani, Fakhroddin; Samani, Elaheh Biglar Beigi; Jazi, Hossein Hadian

    2013-01-01

    Assessment is one of the most essential parts of any instructive learning process which aims to evaluate a learner's knowledge about learning concepts. In this work, a new method for learner assessment based on learner annotations is presented. The proposed method exploits the M-BLEU algorithm to find the most similar reference annotations…

  3. Supporting a Learner Community with Software Agents

    ERIC Educational Resources Information Center

    Taurisson, Neil; Tchounikine, Pierre

    2004-01-01

    This paper describes a multi-agent approach that aims at supporting learners involved in a collective activity. We consider pedagogical situations where students have to explicitly define the articulation of their collective work and then achieve the different tasks they have defined. Our objective is to support these students by taking some of…

  4. Motivating Literacy Learners in Today's World

    ERIC Educational Resources Information Center

    Fletcher, J., Ed.; Parkhill, F., Ed.; Gillon, G., Ed.

    2010-01-01

    "Motivating Literacy Learners in Today's World" provides insights into a broad spectrum of children's literacy learning. Motivation is the key theme and the authors show how this can be achieved through reading for pleasure; in writing activities at a number of levels; and through oral language development. Chapters include: (1)…

  5. Goals, the Learner, and the Language Arts.

    ERIC Educational Resources Information Center

    Ediger, Marlow

    Teachers, principals, and supervisors need to determine the kinds of learners being taught in the school/class setting. Are pupils good by nature, bad, or neutral? Concepts held pertaining to each pupil assist in determining objectives, learning activities, and evaluation techniques. The Puritans believed that individuals were born evil or sinful.…

  6. Hypermedia Design as Learner Scaffolding

    ERIC Educational Resources Information Center

    Shapiro, Amy M.

    2008-01-01

    A number of available resources offer guidance about hypermedia design strategies, many of which rely on principles of user-centered design. Many recent efforts, however, have focused more on developing "learner-centered" hypermedia. Learner-centered hypermedia is designed to help learners achieve their educational goals, rather than offer mere…

  7. Doing Your Part To Help Your Child Become SMART (Successful, Motivated, Autonomous, Responsible, Thoughtful): Six Workshops on Parenting SMART Learners.

    ERIC Educational Resources Information Center

    Sattes, Beth; Walsh, Jackie; Hickman, Mickey

    A SMART Learner is a lifelong learner who can adapt to rapid change and who possesses characteristics associated with success in and out of school. These workshop materials to help parents help their children become SMART learners provide: information from current research and best practice; learning activities that will actively engage parents in…

  8. 29 CFR 779.110 - Employees in retailing whose activities may bring them under the Act.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... retail or service field whose individual activities constitute engagement in interstate or foreign... individual activities ordinarily constitute engagement in commerce or in the production of goods for...

  9. Annual Report to the President and the Congress on Federal Activities Related to the Administration of the Rehabilitation Act of 1973, as Amended. Fiscal Year 1981. Executive Summary.

    ERIC Educational Resources Information Center

    Rehabilitation Services Administration (ED), Washington, DC.

    The fiscal year 1981 annual report of the Rehabilitation Services Administration's activities under the Rehabilitation Act of 1973, as amended, is presented; program operations, program development activities, functions of the National Institute of Handicapped Research, and other provisions of the Act, are described. Program operations include:…

  10. Fragile Identities: Exploring Learner Identity, Learner Autonomy and Motivation through Young Learners' Voices

    ERIC Educational Resources Information Center

    Lamb, Terry Eric

    2011-01-01

    Recent research in the fields of motivation and learner autonomy in language learning has begun to explore their relationships to the construct of identity. This article builds on this through the voices of a group of six learners of French or German in a secondary school in England, over a two-year period. These young learners initially reveal a…

  11. The Learning of Complex Speech Act Behaviour.

    ERIC Educational Resources Information Center

    Olshtain, Elite; Cohen, Andrew

    1990-01-01

    Pre- and posttraining measurement of adult English-as-a-Second-Language learners' (N=18) apology speech act behavior found no clear-cut quantitative improvement after training, although there was an obvious qualitative approximation of native-like speech act behavior in terms of types of intensification and downgrading, choice of strategy, and…

  12. The Activity Support Scale for Multiple Groups (ACTS-MG): Child-reported Physical Activity Parenting in African American and Non-Hispanic White Families.

    PubMed

    Lampard, Amy M; Nishi, Akihiro; Baskin, Monica L; Carson, Tiffany L; Davison, Kirsten K

    2016-01-01

    This study aimed to assess the psychometric properties of a child-report, multidimensional measure of physical activity (PA) parenting, the Activity Support Scale for Multiple Groups (ACTS-MG), in African American and non-Hispanic white families. The ACTS-MG was administered to children aged 5 to 12 years. A three factor model of PA parenting (Modeling of PA, Logistic Support, and Restricting Access to Screen-based Activities) was tested separately for mother's and fathers' PA parenting. The proposed three-factor structure was supported in both racial groups for mothers' PA parenting and in the African American sample for fathers' PA parenting. Factorial invariance between racial groups was demonstrated for mother's PA parenting. Building on a previous study examining the ACTS-MG parent-report, this study supports the use of the ACTS-MG child-report for mothers' PA parenting. However, further research is required to investigate the measurement of fathers' PA parenting across racial groups.

  13. Supporting Language Learners

    ERIC Educational Resources Information Center

    Cady, Jo Ann; Hodges, Thomas E.; Brown, Clara Lee

    2010-01-01

    English Language Learners (ELLs) have an increasing presence in the nations' classrooms. From 1991 to 2004 the number of ELLs nearly doubled in grades K-12. Furthermore, new forms of accountability have school personnel concerned with the progress--or lack of progress--of the ELLs. "Principles and Standards" also reflects this concern: The Equity…

  14. California's English Learner Students

    ERIC Educational Resources Information Center

    Hill, Laura E.

    2012-01-01

    English Learner (EL) students in California's schools are numerous and diverse, and they lag behind their native-English-speaking peers. Closing the achievement gap for EL students has been a long-standing goal for California educators, and there are some signs of success. Now that EL funding and curriculum issues are receiving a fresh level of…

  15. School Learners & Libraries.

    ERIC Educational Resources Information Center

    Karlsson, Jenni, Ed.

    This document presents papers from a conference held in November 1995 in Durban, KwaZulu-Natal, convened by the Education Policy Unit (EPU) of the University of Natal as part of research concerning the provision of library-based resources for school learners. Following an introduction are two chapters: "Identifying the Inherited Problems in…

  16. Literacy and the Learner.

    ERIC Educational Resources Information Center

    World Education, Inc. Reports, 1987

    1987-01-01

    This journal issue focuses on the learner, looks at why literacy has become a major concern and examines the changes brought about by the mastery of new skills. "Literacy/Illiteracy in an International Perspective" (Carman St. John Hunter) frames the discussion by stressing that literacy and illiteracy are moving targets, not fixed by…

  17. Serving the Online Learner

    ERIC Educational Resources Information Center

    Boettcher, Judith V.

    2007-01-01

    Systems and services for recruiting, advising, and support of online students have seldom been at the top of the list when planning online and distance learning programs. That is now changing: Forces pushing advising and support services into the foreground include recognition of the student learner as "customer" and the increasing…

  18. Gender and Learner Characteristics

    ERIC Educational Resources Information Center

    Hindal, Huda; Reid, Norman; Whitehead, Rex

    2013-01-01

    It is well established that girls and boys perform differently in traditional examinations in most countries. This study looks at a sample of 754 school students in Kuwait (aged about 13) and explores how boys and girls differ in the performance in a range of tests related to learner characteristics. The fundamental question is how boys and girls…

  19. Helping Young Hispanic Learners

    ERIC Educational Resources Information Center

    Garcia, Eugene E.; Jensen, Bryant

    2007-01-01

    Hispanics are the largest and youngest ethnic group in the United States. Moreover, young Hispanic children make up approximately 80 percent of the U.S. English language learner population. They are a heterogeneous group, born both inside and outside the United States and having origins in Mexico, Cuba, Central America, South America, and the…

  20. The Transliterate Learner

    ERIC Educational Resources Information Center

    Bush, Gail

    2012-01-01

    Thomas et al. have defined transliteracy as "the ability to read, write and interact across a range of platforms, tools and media from signing and orality through handwriting, print, TV, radio and film, to digital social networks" (Transliteracy Research Group). The learner who is transliterate builds knowledge, communicates, and interacts across…

  1. Learner Autonomy Revisited

    ERIC Educational Resources Information Center

    Illes, Eva

    2012-01-01

    This article explores whether the perception of learner autonomy that is promoted in language pedagogy is suitable for preparing students to perform successfully in the changed circumstances of the use of English. Recent developments, which include the growing role of English as a lingua franca and computer-mediated communication (CMC), give rise…

  2. Helping Gifted Learners Soar

    ERIC Educational Resources Information Center

    Rakow, Susan

    2012-01-01

    Whenever educators talk about raising achievement, grade-level standards are most frequently the end goal for student learning. But what about students who have already met some, if not all, of those standards and who master material quickly and in-depth? Advanced and gifted learners often languish in our schools because teachers don't have the…

  3. The Savvy Learner

    ERIC Educational Resources Information Center

    Dealtry, Richard

    2004-01-01

    This article defines the cultural nature and scale of change in learning consciousness that has to take place when the organizationally-based adult learner makes the transition from formal prescriptive learning practice to self-owned, self-directed learning. It articulates some of the learning-to-learn process models that introduce, accelerate,…

  4. of Iranian EFL Learners

    ERIC Educational Resources Information Center

    Rashidi, Nasser; Mortazavi, Fariba

    2012-01-01

    This research investigated the relationship between vocabulary learning strategies and vocabulary size of Iranian university EFL students. Participants in the present study were a total of 67 EFL learners, studying at Shiraz Azad University as senior English Translation students. The instruments utilized for data collection were three tests: A…

  5. Integrated application of active controls (IAAC) technology to an advanced subsonic transport project. Initial ACT configuration design study

    NASA Technical Reports Server (NTRS)

    1980-01-01

    The initial ACT configuration design task of the integrated application of active controls (IAAC) technology project within the Energy Efficient Transport Program is summarized. A constrained application of active controls technology (ACT) resulted in significant improvements over a conventional baseline configuration previously established. The configuration uses the same levels of technology, takeoff gross weight, payload, and design requirements/objectives as the baseline, except for flying qualities, flutter, and ACT. The baseline wing is moved forward 1.68 m. The configuration incorporates pitch-augmented stability (which enabled an approximately 10% aft shift in cruise center of gravity and a 45% reduction in horizontal tail size), lateral/directional-augmented stability, an angle of attack limiter, wing load alleviation, and flutter mode control. This resulted in a 930 kg reduction in airplane operating empty weight and a 3.6% improvement in cruise efficiency, yielding a 13% range increase. Adjusted to the 3590 km baseline mission range, this amounts to 6% block fuel reduction and a 15.7% higher incremental return on investment, using 1978 dollars and fuel cost.

  6. Interlanguage Pragmatics Study of Compliments among Thai EFL Learners

    ERIC Educational Resources Information Center

    Worathumrong, Sakulrat; Luksaneeyanawin, Sudaporn

    2016-01-01

    This study compares how the native speakers of Thai (TTs) and American (AEs) as well as the Thai learners of English as a foreign language with high exposure to English (TEHs) and those with the low exposure (TELs) perform the speech acts of compliments (Cs) by taking the context of age into their consideration. The data were collected by means of…

  7. Validity Issues in Assessing English Language Learners' Language Proficiency

    ERIC Educational Resources Information Center

    Wolf, Mikyung Kim; Farnsworth, Tim; Herman, Joan

    2008-01-01

    The No Child Left Behind Act has made a great impact on states' policies in assessing English language learner (ELL) students. The legislation requires states to develop or adopt sound assessments to validly measure the ELL students' English language proficiency (ELP). Although states have moved rapidly to meet these requirements, they face…

  8. Application of the French Space Operation Act and the Development of Space Activities in the Field of Launchers

    NASA Astrophysics Data System (ADS)

    Cahuzac, F.; Biard, A.

    2012-01-01

    The development of space activities has led France to define a new legal framework: French Space Operation Act (FSOA). The aim of this act, is to define the conditions according to which the French government authorizes and checks the spatial operations under its jurisdiction or its international responsibility as State of launch, according to the international treaties of the UN on space, in particular the Treaty (1967) on Principles Governing the Activities of States in the Exploration and Use of Outer Space, the Convention ( 1972 ) on International Liability for Damage Caused by Space Objects, and the Convention (1975) on Registration of Objects Launched into Outer Space. The main European space centre is the Guiana Space Centre (CSG), settled in France. A clarification of the French legal framework was compulsory to allow the arrival of new launchers (Soyuz and Vega). This act defines the competent authority, the procedure of authorization and licenses, the regime for operations led from foreign countries, the control of spatial objects, the enabling of inspectors, the delegation of monitoring to CNES, the procedure for urgent measures necessary for the safety, the registration of spatial objects. In this framework, the operator is fully responsible of the operation that he leads. He is subjected to a regime of authorization and to governmental technical monitoring delegated to CNES. In case of litigation, the operator gets the State guarantee above a certain level of damage to third party. The introduction of FSOA has led to issue a Technical Regulation set forth, in particular for the safety of persons and property, the protection of public health and the environment. This general regulation is completed by a specific regulation applicable to CSG that covers the preparation phase of the launch, and all specificities of the launch range, as regards the beginning of the launch. The Technical Regulation is based on 30 years of Ariane's activities and on the

  9. Annual Report to the President and to the Congress on Federal Activities Related to the Rehabilitation Act of 1973, as Amended. Fiscal Year 1995.

    ERIC Educational Resources Information Center

    Rehabilitation Services Administration (ED), Washington, DC.

    This report documents activities and accomplishments of the Rehabilitation Services Administration and the National Institute on Disability and Rehabilitation Research during fiscal year 1995 as mandated under the Rehabilitation Act of 1973. An executive summary briefly describes the programs authorized under the Act and highlights major…

  10. VAV-1 acts in a single interneuron to inhibit motor circuit activity in Caenorhabditis elegans.

    PubMed

    Fry, Amanda L; Laboy, Jocelyn T; Norman, Kenneth R

    2014-11-21

    The complex molecular and cellular mechanisms underlying neuronal control of animal movement are not well understood. Locomotion of Caenorhabditis elegans is mediated by a neuronal circuit that produces coordinated sinusoidal movement. Here we utilize this simple, yet elegant, behaviour to show that VAV-1, a conserved guanine nucleotide exchange factor for Rho-family GTPases, negatively regulates motor circuit activity and the rate of locomotion. While vav-1 is expressed in a small subset of neurons, we find that VAV-1 function is required in a single interneuron, ALA, to regulate motor neuron circuit activity. Furthermore, we show by genetic and optogenetic manipulation of ALA that VAV-1 is required for the excitation and activation of this neuron. We find that ALA signalling inhibits command interneuron activity by abrogating excitatory signalling in the command interneurons, which is responsible for promoting motor neuron circuit activity. Together, our data describe a novel neuromodulatory role for VAV-1-dependent signalling in the regulation of motor circuit activity and locomotion.

  11. PP2A and GSK-3beta act antagonistically to regulate active zone development.

    PubMed

    Viquez, Natasha M; Füger, Petra; Valakh, Vera; Daniels, Richard W; Rasse, Tobias M; DiAntonio, Aaron

    2009-09-16

    The synapse is composed of an active zone apposed to a postsynaptic cluster of neurotransmitter receptors. Each Drosophila neuromuscular junction comprises hundreds of such individual release sites apposed to clusters of glutamate receptors. Here, we show that protein phosphatase 2A (PP2A) is required for the development of structurally normal active zones opposite glutamate receptors. When PP2A is inhibited presynaptically, many glutamate receptor clusters are unapposed to Bruchpilot (Brp), an active zone protein required for normal transmitter release. These unapposed receptors are not due to presynaptic retraction of synaptic boutons, since other presynaptic components are still apposed to the entire postsynaptic specialization. Instead, these data suggest that Brp localization is regulated at the level of individual release sites. Live imaging of glutamate receptors demonstrates that this disruption to active zone development is accompanied by abnormal postsynaptic development, with decreased formation of glutamate receptor clusters. Remarkably, inhibition of the serine-threonine kinase GSK-3beta completely suppresses the active zone defect, as well as other synaptic morphology phenotypes associated with inhibition of PP2A. These data suggest that PP2A and GSK-3beta function antagonistically to control active zone development, providing a potential mechanism for regulating synaptic efficacy at a single release site.

  12. Long-acting neuroleptics used in wildlife management do not impair thermoregulation or physical activity in goats (Capra hircus).

    PubMed

    Fick, Linda; Mitchell, Duncan; Fuller, Andrea

    2007-06-01

    Long-acting neuroleptics commonly are used in wildlife management to decrease stress-related mortality in wild animals, but with possible effects on thermoregulation, which may contribute to residual morbidity and mortality. We investigated the effects of haloperidol (0.01, 0.1, 1 mg kg(-1), n=4), zuclopenthixol (0.1, 1, 10 mg kg(-1), n=4) and perphenazine (0.1, 1, 10 mg kg(-1), n=8), as well as control injections of sunflower oil, on body temperature and physical activity of laboratory goats under hot, cold and thermoneutral ambient temperatures. Implanted data loggers continuously recorded abdominal temperature, and data loggers attached externally on the foreleg recorded movement of unrestrained goats, in a climatic chamber at 35 degrees C, 10 degrees C and 22 degrees C. Cycling ambient temperature between 35 degrees C in daytime and 10 degrees C at night time caused a significant increase in amplitude of the circadian rhythm of body temperature in goats given sunflower oil (P=0.0012, unpaired t-test, n=8), but the administration of zuclopenthixol or perphenazine did not affect this change in amplitude (P>0.05, two-way ANOVA, n=4). Mean daily body temperature after administration of zuclopenthixol or perphenazine, and mean daily activity after zuclopenthixol administration, were not significantly different to those after control injections, at any ambient temperature, for the expected duration of drug activity (all P>0.05, two-way ANOVA, n=4). Thermal response indices, and mean activity, during heat, cold or thermoneutral exposure, of goats for 7 h after haloperidol injection, were not significantly different, at any dose or any ambient temperature, to those following control injections (all P>0.05, repeated measures ANOVA, n=4). Long-acting neuroleptics did not impair activity or thermoregulation of goats subjected to inescapable thermal challenges.

  13. GATA1 Activity Governed by Configurations of cis-Acting Elements.

    PubMed

    Hasegawa, Atsushi; Shimizu, Ritsuko

    2016-01-01

    The transcription factor GATA1 regulates the expression of essential erythroid and megakaryocytic differentiation genes through binding to the DNA consensus sequence WGATAR. The GATA1 protein has four functional domains, including two centrally located zinc-finger domains and two transactivation domains at the N- and C-termini. These functional domains play characteristic roles in the elaborate regulation of diversified GATA1 target genes, each of which exhibits a unique expression profile. Three types of GATA1-related hematological malignancies have been reported. One is a structural mutation in the GATA1 gene, resulting in the production of a short form of GATA1 that lacks the N-terminal transactivation domain and is found in Down syndrome-related acute megakaryocytic leukemia. The other two are cis-acting regulatory mutations affecting expression of the Gata1 gene, which have been shown to cause acute erythroblastic leukemia and myelofibrosis in mice. Therefore, imbalanced gene regulation caused by qualitative and quantitative changes in GATA1 is thought to be involved in specific hematological disease pathogenesis. In the present review, we discuss recent advances in understanding the mechanisms of differential transcriptional regulation by GATA1 during erythroid differentiation, with special reference to the binding kinetics of GATA1 at conformation-specific binding sites.

  14. GATA1 Activity Governed by Configurations of cis-Acting Elements

    PubMed Central

    Hasegawa, Atsushi; Shimizu, Ritsuko

    2017-01-01

    The transcription factor GATA1 regulates the expression of essential erythroid and megakaryocytic differentiation genes through binding to the DNA consensus sequence WGATAR. The GATA1 protein has four functional domains, including two centrally located zinc-finger domains and two transactivation domains at the N- and C-termini. These functional domains play characteristic roles in the elaborate regulation of diversified GATA1 target genes, each of which exhibits a unique expression profile. Three types of GATA1-related hematological malignancies have been reported. One is a structural mutation in the GATA1 gene, resulting in the production of a short form of GATA1 that lacks the N-terminal transactivation domain and is found in Down syndrome-related acute megakaryocytic leukemia. The other two are cis-acting regulatory mutations affecting expression of the Gata1 gene, which have been shown to cause acute erythroblastic leukemia and myelofibrosis in mice. Therefore, imbalanced gene regulation caused by qualitative and quantitative changes in GATA1 is thought to be involved in specific hematological disease pathogenesis. In the present review, we discuss recent advances in understanding the mechanisms of differential transcriptional regulation by GATA1 during erythroid differentiation, with special reference to the binding kinetics of GATA1 at conformation-specific binding sites. PMID:28119852

  15. Primary afferent terminals acting as excitatory interneurons contribute to spontaneous motor activities in the immature spinal cord.

    PubMed

    Bos, Rémi; Brocard, Frédéric; Vinay, Laurent

    2011-07-13

    Patterned, spontaneous activity plays a critical role in the development of neuronal networks. A robust spontaneous activity is observed in vitro in spinal cord preparations isolated from immature rats. The rhythmic ventral root discharges rely mainly on the depolarizing/excitatory action of GABA and glycine early during development, whereas at later stages glutamate drive is primarily responsible for the rhythmic activity and GABA/glycine are thought to play an inhibitory role. However, rhythmic discharges mediated by the activation of GABA(A) receptors are recorded from dorsal roots (DRs). In the present study, we used the in vitro spinal cord preparation of neonatal rats to identify the relationship between discharges that are conducted antidromically along DRs and the spontaneous activity recorded from lumbar motoneurons. We show that discharges in DRs precede those in ventral roots and that primary afferent depolarizations (PADs) start earlier than EPSPs in motoneurons. EPSP-triggered averaging revealed that the action potentials propagate not only antidromically in the DR but also centrally and trigger EPSPs in motoneurons. Potentiating GABAergic antidromic discharges by diazepam increased the EPSPs recorded from motoneurons; conversely, blocking DR bursts markedly reduced these EPSPs. High intracellular concentrations of chloride are maintained in primary afferent terminals by the sodium-potassium-chloride cotransporter NKCC1. Blocking these cotransporters by bumetanide decreased both dorsal and ventral root discharges. We conclude that primary afferent fibers act as excitatory interneurons and that GABA, through PADs reaching firing threshold, is still playing a key role in promoting spontaneous activity in neonates.

  16. Balancing act: approaches to healthy eating and physical activity among Boston public housing residents.

    PubMed

    Scammell, Madeleine Kangsen; Torres, Shioban; Wayman, Julie; Greenwood, Nechama; Thomas, Gerry; Kozlowski, Lauren; Bowen, Deborah

    2015-01-01

    Boston public housing residents are more likely to report fair or poor health status, been diagnosed with obesity, and to be physically inactive compared with other Boston residents (Digenis-Bury, Brooks, Chen, Ostrem, & Horsburgh, 2008 ). Little is known about perceptions of and opportunities for healthy eating and physical activity in this population. We conducted eight focus groups at public housing developments to explore residents' views regarding opportunities and barriers to healthy eating and physical activity. Sixty-seven English- and Spanish-speaking residents participated. Transcripts were analyzed using qualitative content analysis. All residents described the challenge of balancing considerations of food quality, access, and affordability. Other findings included underutilized nutritional resources; abundant availability of unhealthy food; and economic and structural barriers to exercise. Transportation-related challenges were a dominant theme. Building opportunities for physical activity and providing access to affordable and quality food choices may be important interventions for promoting health among public housing residents.

  17. Two different factors act separately or together to specify functionally distinct activities at a single transcriptional enhancer.

    PubMed Central

    DeFranco, D; Yamamoto, K R

    1986-01-01

    The expression of genes fused downstream of the Moloney murine sarcoma virus (MoMSV) long terminal repeat is stimulated by glucocorticoids. We mapped the glucocorticoid response element that conferred this hormonal regulation and found that it is a hormone-dependent transcriptional enhancer, designated Sg; it resides within DNA fragments that also carry a previously described enhancer element (B. Levinson, G. Khoury, G. Vande Woude, and P. Gruss, Nature [London] 295:568-572, 1982), here termed Sa, whose activity is independent of the hormone. Nuclease footprinting revealed that purified glucocorticoid receptor bound at multiple discrete sites within and at the borders of the tandemly repeated sequence motif that defines Sa. The Sa and Sg activities stimulated the apparent efficiency of cognate or heterologous promoter utilization, individually providing modest enhancement and in concert yielding higher levels of activity. A deletion mutant lacking most of the tandem repeat but retaining a single receptor footprint sequence lost Sa activity but still conferred Sg activity. The two enhancer components could also be distinguished physiologically: both were operative within cultured rat fibroblasts, but only Sg activity was detectable in rat exocrine pancreas cells. Therefore, the sequence determinants of Sa and Sg activity may be interdigitated, and when both components are active, the receptor and a putative Sa factor can apparently bind and act simultaneously. We concluded that MoMSV enhancer activity is effected by at least two distinct binding factors, suggesting that combinatorial regulation of promoter function can be mediated even from a single genetic element. Images PMID:3023887

  18. LIME acts as a transmembrane adapter mediating BCR-dependent B-cell activation.

    PubMed

    Ahn, Eunseon; Lee, Hyunsook; Yun, Yungdae

    2006-02-15

    Assembly of a signaling complex around the transmembrane adapter LAT is essential for the transmission of T-cell receptor (TCR)-mediated signaling. However, a LAT-like molecule responsible for the initial activation events in B-cell receptor (BCR) signaling has not yet been identified. Here, we show that LIME is a transmembrane adaptor required for BCR-mediated B-cell activation. LIME was found to be expressed in mouse splenic B cells. Upon BCR cross-linking, LIME was tyrosine phosphorylated by Lyn and associated with Lyn, Grb2, PLC-gamma2, and PI3K. Reduction of LIME expression by the introduction of siRNA resulted in the disruption of BCR-mediated activation of MAPK, calcium flux, NF-AT, PI3K, and NF-kappaB. Taken together, these results establish that LIME is an essential transmembrane adaptor linking BCR ligation to the downstream signaling events that lead to B-cell activation.

  19. 77 FR 35323 - National Environmental Policy Act: Categorical Exclusions for Soil and Water Restoration Activities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-13

    ... scientific analyses, research papers, and monitoring reports about activities identified under these... property. Civil Justice Reform The Agency has reviewed this proposed rule under Executive Order 12988 of February 7, 1996, ``Civil Justice Reform.'' After adoption of this proposed rule, (1) all state and...

  20. 78 FR 25477 - Agency Information Collection Activities; Submission for OMB Review; Comment Request; Trade Act...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-01

    ... management information to the Congress and other Federal agencies, and to improve the effectiveness of job... technological collection techniques or other forms of information technology, e.g., permitting electronic... of the Secretary Agency Information Collection Activities; Submission for OMB Review; Comment...

  1. Learner Preferences and Achievement Under Differing Amounts of Learner Practice.

    ERIC Educational Resources Information Center

    Schnackenberg, Heidi L.; Sullivan, Howard J.; Leader, Lars F.; Jones, Elizabeth E. K.

    1998-01-01

    Examines the effects of program mode (i.e., a lean program version containing a basic amount of learner practice versus a full mode containing expanded practice) and learner preference (matched or unmatched) for amount of practice on the achievement, time-in-program, and attitudes of university undergraduate students. Students preferred the lean…

  2. Protein disulfide isomerase acts as an injury response signal that enhances fibrin generation via tissue factor activation

    PubMed Central

    Reinhardt, Christoph; von Brühl, Marie-Luise; Manukyan, Davit; Grahl, Lenka; Lorenz, Michael; Altmann, Berid; Dlugai, Silke; Hess, Sonja; Konrad, Ildiko; Orschiedt, Lena; Mackman, Nigel; Ruddock, Lloyd; Massberg, Steffen; Engelmann, Bernd

    2008-01-01

    The activation of initiator protein tissue factor (TF) is likely to be a crucial step in the blood coagulation process, which leads to fibrin formation. The stimuli responsible for inducing TF activation are largely undefined. Here we show that the oxidoreductase protein disulfide isomerase (PDI) directly promotes TF-dependent fibrin production during thrombus formation in vivo. After endothelial denudation of mouse carotid arteries, PDI was released at the injury site from adherent platelets and disrupted vessel wall cells. Inhibition of PDI decreased TF-triggered fibrin formation in different in vivo murine models of thrombus formation, as determined by intravital fluorescence microscopy. PDI infusion increased — and, under conditions of decreased platelet adhesion, PDI inhibition reduced — fibrin generation at the injury site, indicating that PDI can directly initiate blood coagulation. In vitro, human platelet–secreted PDI contributed to the activation of cryptic TF on microvesicles (microparticles). Mass spectrometry analyses indicated that part of the extracellular cysteine 209 of TF was constitutively glutathionylated. Mixed disulfide formation contributed to maintaining TF in a state of low functionality. We propose that reduced PDI activates TF by isomerization of a mixed disulfide and a free thiol to an intramolecular disulfide. Our findings suggest that disulfide isomerases can act as injury response signals that trigger the activation of fibrin formation following vessel injury. PMID:18274674

  3. The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons.

    PubMed

    Cho, Hawon; Yang, Young Duk; Lee, Jesun; Lee, Byeongjoon; Kim, Tahnbee; Jang, Yongwoo; Back, Seung Keun; Na, Heung Sik; Harfe, Brian D; Wang, Fan; Raouf, Ramin; Wood, John N; Oh, Uhtaek

    2012-05-27

    Nociceptors are a subset of small primary afferent neurons that respond to noxious chemical, thermal and mechanical stimuli. Ion channels in nociceptors respond differently to noxious stimuli and generate electrical signals in different ways. Anoctamin 1 (ANO1 also known as TMEM16A) is a Ca(2+)-activated chloride channel that is essential for numerous physiological functions. We found that ANO1 was activated by temperatures over 44 °C with steep heat sensitivity. ANO1 was expressed in small sensory neurons and was highly colocalized with nociceptor markers, which suggests that it may be involved in nociception. Application of heat ramps to dorsal root ganglion (DRG) neurons elicited robust ANO1-dependent depolarization. Furthermore, knockdown or deletion of ANO1 in DRG neurons substantially reduced nociceptive behavior in thermal pain models. These results indicate that ANO1 is a heat sensor that detects nociceptive thermal stimuli in sensory neurons and possibly mediates nociception.

  4. DJ-1 Is a Copper Chaperone Acting on SOD1 Activation*

    PubMed Central

    Girotto, Stefania; Cendron, Laura; Bisaglia, Marco; Tessari, Isabella; Mammi, Stefano; Zanotti, Giuseppe; Bubacco, Luigi

    2014-01-01

    Lack of oxidative stress control is a common and often prime feature observed in many neurodegenerative diseases. Both DJ-1 and SOD1, proteins involved in familial Parkinson disease and amyotrophic lateral sclerosis, respectively, play a protective role against oxidative stress. Impaired activity and modified expression of both proteins have been observed in different neurodegenerative diseases. A potential cooperative action of DJ-1 and SOD1 in the same oxidative stress response pathway may be suggested based on a copper-mediated interaction between the two proteins reported here. To investigate the mechanisms underlying the antioxidative function of DJ-1 in relation to SOD1 activity, we investigated the ability of DJ-1 to bind copper ions. We structurally characterized a novel copper binding site involving Cys-106, and we investigated, using different techniques, the kinetics of DJ-1 binding to copper ions. The copper transfer between the two proteins was also examined using both fluorescence spectroscopy and specific biochemical assays for SOD1 activity. The structural and functional analysis of the novel DJ-1 copper binding site led us to identify a putative role for DJ-1 as a copper chaperone. Alteration of the coordination geometry of the copper ion in DJ-1 may be correlated to the physiological role of the protein, to a potential failure in metal transfer to SOD1, and to successive implications in neurodegenerative etiopathogenesis. PMID:24567322

  5. Electronically Integrated Active Compliant Transmission (ACT) Actuation Technologies Proof-of-Concept Investigation of Active Velcro for Smart Attachment Mechanisms

    DTIC Science & Technology

    2006-05-31

    down and be in the center position when off, the current amplification systems that exploit very high energy density materials (such as EC98 by EDO ...project was the synergistic development of complete piezoelectric actuation systems with integrated electronic drivers, material transduction and Active...4 1.2.1. INSTAR System Description

  6. Cytokinins act synergistically with salicylic acid to activate defense gene expression in rice.

    PubMed

    Jiang, Chang-Jie; Shimono, Masaki; Sugano, Shoji; Kojima, Mikiko; Liu, Xinqiong; Inoue, Haruhiko; Sakakibara, Hitoshi; Takatsuji, Hiroshi

    2013-03-01

    Hormone crosstalk is pivotal in plant-pathogen interactions. Here, we report on the accumulation of cytokinins (CK) in rice seedlings after infection of blast fungus Magnaporthe oryzae and its potential significance in rice-M. oryzae interaction. Blast infection to rice seedlings increased levels of N(6)-(Δ(2)-isopentenyl) adenine (iP), iP riboside (iPR), and iPR 5'-phosphates (iPRP) in leaf blades. Consistent with this, CK signaling was activated around the infection sites, as shown by histochemical staining for β-glucuronidase activity driven by a CK-responsive OsRR6 promoter. Diverse CK species were also detected in the hyphae (mycelium), conidia, and culture filtrates of blast fungus, indicating that M. oryzae is capable of production as well as hyphal secretion of CK. Co-treatment of leaf blades with CK and salicylic acid (SA), but not with either one alone, markedly induced pathogenesis-related genes OsPR1b and probenazole-induced protein 1 (PBZ1). These effects were diminished by RNAi-knockdown of OsNPR1 or WRKY45, the key regulators of the SA signaling pathway in rice, indicating that the effects of CK depend on these two regulators. Taken together, our data imply a coevolutionary rice-M. oryzae interaction, wherein M. oryzae probably elevates rice CK levels for its own benefits such as nutrient translocation. Rice plants, on the other hand, sense it as an infection signal and activate defense reactions through the synergistic action with SA.

  7. Demonized Learners in Sociocultural Theory

    ERIC Educational Resources Information Center

    Chen, Joanna

    2016-01-01

    Within the frameworks of Sociocultural theory, particularly Vygotskian sociocultural theory and ZPD, Lave and Wenger's CoP, and contemporary sociocultural theory, this paper seeks to examine the unfavourable scholarly portrayal of learners and their identities based on learners' behaviours, attitudes, and beliefs about the social element of…

  8. College Centers for Older Learners.

    ERIC Educational Resources Information Center

    Smith, Judith L.

    Across the nation, colleges are discovering a new group of students: retired learners. Special programs are emerging to meet the unique needs and interests of this mature population. This booklet describes these programs under the generic title, College Centers for Older Learners (CCOLs). CCOLs offer a stimulating college environment for older…

  9. The Generative Adolescent Mathematical Learner

    ERIC Educational Resources Information Center

    Lawler, Brian R.

    2010-01-01

    The purpose of this paper is to consider the personal epistemologies of generative adolescent mathematical learners. A generative disposition defined a learner who operated mathematically in ways that reflect an internalized authority for knowing and a constructive orientation to knowledge. Drawing upon the radical constructivist teaching…

  10. Chinese English Learners' Strategic Competence

    ERIC Educational Resources Information Center

    Wang, Dianjian; Lai, Hongling; Leslie, Michael

    2015-01-01

    The present study aims to investigate Chinese English learners' ability to use communication strategies (CSs). The subjects are put in a relatively real English referential communication setting and the analyses of the research data show that Chinese English learners, when encountering problems in foreign language (FL) communication, are…

  11. Assistive Software for Disabled Learners

    ERIC Educational Resources Information Center

    Clark, Sharon; Baggaley, Jon

    2004-01-01

    Previous reports in this series (#32 and 36) have discussed online software features of value to disabled learners in distance education. The current report evaluates four specific assistive software products with useful features for visually and hearing impaired learners: "ATutor", "ACollab", "Natural Voice", and "Just Vanilla". The evaluative…

  12. The Adult Learner: Four Aspects.

    ERIC Educational Resources Information Center

    Lucas, John A., Ed.

    1986-01-01

    Topics concerning the adult learner that are relevant to institutional researchers are addressed in four articles: marketing, predicting success for adult students, enrollment projection, and follow-up studies of adult learners. In "Institutional Research in Support of Marketing the Adult Student," Lydia Jurand notes the importance of…

  13. High Ability and Learner Characteristics

    ERIC Educational Resources Information Center

    Hindal, Huda; Reid, Norman; Whitehead, Rex

    2013-01-01

    The outstandingly able learner has been conceptualised, in terms of test and examination performance, as the learner showing superior academic performance which is markedly better than that of peers and in ways regarded as of value by wider society. In Kuwait, such superior examination performance leads to a classification regarded as being…

  14. Learner Intonation -- A Pilot Study.

    ERIC Educational Resources Information Center

    Backman, Nancy

    This study is concerned with problems in language learners' intonation of English. Ten intonation problems were found in the learner speech of two adult Spanish-speaking males: (1) range of pitch, (2) initial rise, (3) final fall, (4) rise to final stressed syllable, (5) placement of prominence, (6) final rise for questions, (7) total question…

  15. Sensitizing ESL Learners to Genre

    ERIC Educational Resources Information Center

    Swami, Jasti Appa

    2008-01-01

    This article evaluates the efficacy of explicit genre-based instruction by sensitizing the ESL learners to the concept of genre. The main questions addressed are: How does sensitizing ESL learners to the rhetorical move structure of a genre, the communicative purposes of these moves, and linguistic features that realize these moves help them to…

  16. Iranian EFL Learners' Compliment Responses

    ERIC Educational Resources Information Center

    Allami, Hamid; Montazeri, Maryam

    2012-01-01

    The present study aimed at examining the knowledge of Iranian EFL learners in responding to compliments in English, with a focus on the variables of gender, age and educational background. The data were collected through a 24-item English Discourse Completion Task (DCT) to which 40 male and female EFL learners were asked to provide short…

  17. Learner Autonomy and New Technologies.

    ERIC Educational Resources Information Center

    Raya, Manuel Jimenez; Fernandez, Jose Maria Perez

    2002-01-01

    Presents paths for theoretical research and practical procedures that may help teachers make new technology pedagogically relevant. Discusses the need to develop learner autonomy to help students process information in meaningful ways and become independent learners by developing effective learning strategies, transfer skills, and a greater sense…

  18. Profiling Mobile English Language Learners

    ERIC Educational Resources Information Center

    Byrne, Jason; Diem, Robert

    2014-01-01

    The purpose of this study was to use an app-embedded survey to profile language learner demographics. A total of 3,759 EFL language learners from primarily eight L1 backgrounds (French, German, Italian, Japanese, Korean, Russian, Spanish and Thai) responded to the survey embedded within a popular English grammar app. This app has over 500,000…

  19. Effective Instruction for English Learners

    ERIC Educational Resources Information Center

    Calderon, Margarita; Slavin, Robert; Sanchez, Marta

    2011-01-01

    The fastest-growing student population in U.S. schools today is children of immigrants, half of whom do not speak English fluently and are thus labeled English learners. Although the federal government requires school districts to provide services to English learners, it offers states no policies to follow in identifying, assessing, placing, or…

  20. Learner Control in Hypermedia Environments

    ERIC Educational Resources Information Center

    Scheiter, Katharina; Gerjets, Peter

    2007-01-01

    Contrary to system-controlled multimedia learning environments, hypermedia systems are characterized by a high level of interactivity. This interactivity is referred to as learner control in the respective literature. For several reasons this learner control is seen as a major advantage of hypermedia for learning and instruction. For instance,…

  1. Learners' Perceptions and Attitudes: Implications for Willingness to Communicate in an L2 Classroom

    ERIC Educational Resources Information Center

    de Saint Leger, Diane; Storch, Neomy

    2009-01-01

    This paper investigates learners' perceptions of their speaking abilities, of their contributions to oral class activities (whole class and small group discussions) as well as their attitudes towards these activities, and how such perceptions and attitudes influenced the learners' willingness to communicate in the L2. The study employed a range of…

  2. Phosphorylation acts positively and negatively to regulate MRTF-A subcellular localisation and activity

    PubMed Central

    Panayiotou, Richard; Miralles, Francesc; Pawlowski, Rafal; Diring, Jessica; Flynn, Helen R; Skehel, Mark; Treisman, Richard

    2016-01-01

    The myocardin-related transcription factors (MRTF-A and MRTF-B) regulate cytoskeletal genes through their partner transcription factor SRF. The MRTFs bind G-actin, and signal-regulated changes in cellular G-actin concentration control their nuclear accumulation. The MRTFs also undergo Rho- and ERK-dependent phosphorylation, but the function of MRTF phosphorylation, and the elements and signals involved in MRTF-A nuclear export are largely unexplored. We show that Rho-dependent MRTF-A phosphorylation reflects relief from an inhibitory function of nuclear actin. We map multiple sites of serum-induced phosphorylation, most of which are S/T-P motifs and show that S/T-P phosphorylation is required for transcriptional activation. ERK-mediated S98 phosphorylation inhibits assembly of G-actin complexes on the MRTF-A regulatory RPEL domain, promoting nuclear import. In contrast, S33 phosphorylation potentiates the activity of an autonomous Crm1-dependent N-terminal NES, which cooperates with five other NES elements to exclude MRTF-A from the nucleus. Phosphorylation thus plays positive and negative roles in the regulation of MRTF-A. DOI: http://dx.doi.org/10.7554/eLife.15460.001 PMID:27304076

  3. Development and validation of quantitative structure-activity relationship models for compounds acting on serotoninergic receptors.

    PubMed

    Zydek, Grażyna; Brzezińska, Elżbieta

    2012-01-01

    A quantitative structure-activity relationship (QSAR) study has been made on 20 compounds with serotonin (5-HT) receptor affinity. Thin-layer chromatographic (TLC) data and physicochemical parameters were applied in this study. RP2 TLC 60F(254) plates (silanized) impregnated with solutions of propionic acid, ethylbenzene, 4-ethylphenol, and propionamide (used as analogues of the key receptor amino acids) and their mixtures (denoted as S1-S7 biochromatographic models) were used in two developing phases as a model of drug-5-HT receptor interaction. The semiempirical method AM1 (HyperChem v. 7.0 program) and ACD/Labs v. 8.0 program were employed to calculate a set of physicochemical parameters for the investigated compounds. Correlation and multiple linear regression analysis were used to search for the best QSAR equations. The correlations obtained for the compounds studied represent their interactions with the proposed biochromatographic models. The good multivariate relationships (R(2) = 0.78-0.84) obtained by means of regression analysis can be used for predicting the quantitative effect of biological activity of different compounds with 5-HT receptor affinity. "Leave-one-out" (LOO) and "leave-N-out" (LNO) cross-validation methods were used to judge the predictive power of final regression equations.

  4. Motivation Classification and Grade Prediction for MOOCs Learners

    PubMed Central

    Xu, Bin; Yang, Dan

    2016-01-01

    While MOOCs offer educational data on a new scale, many educators find great potential of the big data including detailed activity records of every learner. A learner's behavior such as if a learner will drop out from the course can be predicted. How to provide an effective, economical, and scalable method to detect cheating on tests such as surrogate exam-taker is a challenging problem. In this paper, we present a grade predicting method that uses student activity features to predict whether a learner may get a certification if he/she takes a test. The method consists of two-step classifications: motivation classification (MC) and grade classification (GC). The MC divides all learners into three groups including certification earning, video watching, and course sampling. The GC then predicts a certification earning learner may or may not obtain a certification. Our experiment shows that the proposed method can fit the classification model at a fine scale and it is possible to find a surrogate exam-taker. PMID:26884747

  5. PEGylated recombinant human interferon-ω as a long-acting antiviral agent: structure, antiviral activity and pharmacokinetics.

    PubMed

    Yu, Weili; Yu, Changming; Wu, Ling; Fang, Ting; Qiu, Rui; Zhang, Jinlong; Yu, Ting; Fu, Ling; Chen, Wei; Hu, Tao

    2014-08-01

    Recombinant human interferon-ω (rhIFN-ω) exhibits a potent antiviral activity. Because of poor pharmacokinetics (PK) of rhIFN-ω, frequent dosing of rhIFN-ω is necessitated to achieve the sustained antiviral efficacy. PEGylation can efficiently improve the PK of rhIFN-ω while substantially decrease its bioactivity. The structure, antiviral activity and PK of the PEGylated rhIFN-ω were measured to establish their relationship with PEGylation sites, polyethylene glycol (PEG) mass and PEG structure. Accordingly, N-terminus and the lysine residues were selected as the PEGylation sites. PEGs with Mw of 20kDa and 40kDa were used to investigate the effect of PEG mass. Linear and branched PEGs were used to investigate the effect of PEG structure. PEGylation decreased the antiviral activity of rhIFN-ω and improved its PK. The PEGylation sites determine the bioactivity of the PEGylated rhIFN-ω and the conjugated PEG mass determines the PK. N-terminally PEGylated rhIFN-ω with 40kDa linear PEG maintains 21.7% of the rhIFN-ω antiviral activity with a half-life of 139.6h. Thus, N-terminally PEGylated rhIFN-ω with linear 40kDa PEG is a potential antiviral agent for long-acting treatment of the viral diseases.

  6. Integrated Application of Active Controls (IAAC) technology to an advanced subsonic transport project. ACT/Control/Guidance System study, volume 1

    NASA Technical Reports Server (NTRS)

    1982-01-01

    The active control technology (ACT) control/guidance system task of the integrated application of active controls (IAAC) technology project within the NASA energy efficient transport program was documented. The air traffic environment of navigation and air traffic control systems and procedures were extrapolated. An approach to listing flight functions which will be performed by systems and crew of an ACT configured airplane of the 1990s, and a determination of function criticalities to safety of flight, are the basis of candidate integrated ACT/Control/Guidance System architecture. The system mechanizes five active control functions: pitch augmented stability, angle of attack limiting, lateral/directional augmented stability, gust load alleviation, and maneuver load control. The scope and requirements of a program for simulating the integrated ACT avionics and flight deck system, with pilot in the loop, are defined, system and crew interface elements are simulated, and mechanization is recommended. Relationships between system design and crew roles and procedures are evaluated.

  7. LATE MERISTEM IDENTITY2 acts together with LEAFY to activate APETALA1.

    PubMed

    Pastore, Jennifer J; Limpuangthip, Andrea; Yamaguchi, Nobutoshi; Wu, Miin-Feng; Sang, Yi; Han, Soon-Ki; Malaspina, Lauren; Chavdaroff, Natasha; Yamaguchi, Ayako; Wagner, Doris

    2011-08-01

    The switch from producing vegetative structures (branches and leaves) to producing reproductive structures (flowers) is a crucial developmental transition that significantly affects the reproductive success of flowering plants. In Arabidopsis, this transition is in large part controlled by the meristem identity regulator LEAFY (LFY). The molecular mechanisms by which LFY orchestrates a precise and robust switch to flower formation is not well understood. Here, we show that the direct LFY target LATE MERISTEM IDENTITY2 (LMI2) has a role in the meristem identity transition. Like LFY, LMI2 activates AP1 directly; moreover, LMI2 and LFY interact physically. LFY, LMI2 and AP1 are connected in a feed-forward and positive feedback loop network. We propose that these intricate regulatory interactions not only direct the precision of this crucial developmental transition in rapidly changing environmental conditions, but also contribute to its robustness and irreversibility.

  8. Cardiolipins Act as a Selective Barrier to Toll-Like Receptor 4 Activation in the Intestine

    PubMed Central

    Coats, Stephen R.; Hashim, Ahmed; Paramonov, Nikolay A.; Curtis, Michael A.

    2016-01-01

    ABSTRACT Intestinal homeostasis mechanisms must protect the host intestinal tissue from endogenous lipopolysaccharides (LPSs) produced by the intestinal microbiota. In this report, we demonstrate that murine intestinal fecal lipids effectively block Toll-like receptor 4 (TLR4) responses to naturally occurring Bacteroidetes sp. LPS. Cardiolipin (CL) represents a significant proportion of the total intestinal and fecal lipids and, furthermore, potently antagonizes TLR4 activation by reducing LPS binding at the lipopolysaccharide binding protein (LBP), CD14, and MD-2 steps of the TLR4 signaling pathway. It is further demonstrated that intestinal lipids and CL are less effective at neutralizing more potent Enterobacteriaceae-type LPS, which is enriched in feces obtained from mice with dextran sodium sulfate (DSS)-treated inflammatory bowel disease. The selective inhibition of naturally occurring LPS structures by intestinal lipids may represent a novel homeostasis mechanism that blocks LPS activation in response to symbiotic but not dysbiotic microbial communities. IMPORTANCE The guts of animals harbor a variety of Gram-negative bacteria associated with both states of intestinal health and states of disease. Environmental factors, such as dietary habits, can drive the microbial composition of the host animal's intestinal bacterial community toward a more pathogenic state. Both beneficial and harmful Gram-negative bacteria are capable of eliciting potentially damaging inflammatory responses from the host intestinal tissues via a lipopolysaccharide (LPS)-dependent pathway. Physical mucosal barriers and antibodies produced by the intestinal immune system protect against the undesired inflammatory effects of LPS, although it is unknown why some bacteria are more effective at overcoming the protective barriers than others. This report describes the discovery of a lipid-type protective barrier in the intestine that reduces the deleterious effects of LPSs from beneficial

  9. GIT2 Acts as a Systems-Level Coordinator of Neurometabolic Activity and Pathophysiological Aging

    PubMed Central

    Martin, Bronwen; Chadwick, Wayne; Janssens, Jonathan; Premont, Richard T.; Schmalzigaug, Robert; Becker, Kevin G.; Lehrmann, Elin; Wood, William H.; Zhang, Yongqing; Siddiqui, Sana; Park, Sung-Soo; Cong, Wei-na; Daimon, Caitlin M.; Maudsley, Stuart

    2016-01-01

    Aging represents one of the most complicated and highly integrated somatic processes. Healthy aging is suggested to rely upon the coherent regulation of hormonal and neuronal communication between the central nervous system and peripheral tissues. The hypothalamus is one of the main structures in the body responsible for sustaining an efficient interaction between energy balance and neurological activity and therefore likely coordinates multiple systems in the aging process. We previously identified, in hypothalamic and peripheral tissues, the G protein-coupled receptor kinase interacting protein 2 (GIT2) as a stress response and aging regulator. As metabolic status profoundly affects aging trajectories, we investigated the role of GIT2 in regulating metabolic activity. We found that genomic deletion of GIT2 alters hypothalamic transcriptomic signatures related to diabetes and metabolic pathways. Deletion of GIT2 reduced whole animal respiratory exchange ratios away from those related to primary glucose usage for energy homeostasis. GIT2 knockout (GIT2KO) mice demonstrated lower insulin secretion levels, disruption of pancreatic islet beta cell mass, elevated plasma glucose, and insulin resistance. High-dimensionality transcriptomic signatures from islets isolated from GIT2KO mice indicated a disruption of beta cell development. Additionally, GIT2 expression was prematurely elevated in pancreatic and hypothalamic tissues from diabetic-state mice (db/db), compared to age-matched wild type (WT) controls, further supporting the role of GIT2 in metabolic regulation and aging. We also found that the physical interaction of pancreatic GIT2 with the insulin receptor and insulin receptor substrate 2 was diminished in db/db mice compared to WT mice. Therefore, GIT2 appears to exert a multidimensional “keystone” role in regulating the aging process by coordinating somatic responses to energy deficits. PMID:26834700

  10. Ten Helpful Ideas for Teaching English to Young Learners

    ERIC Educational Resources Information Center

    Shin, Joan Kang

    2006-01-01

    This article offers ten suggestions for teaching young learners between the age of 7 and 12 based on language-teaching principles. They include supplementing activities with visuals, realia and movement; involving students in making visuals and realia; moving from activity to activity; teaching in themes; using stories and contexts familiar to…

  11. Screening of plants acting against Heterometrus laoticus scorpion venom activity on fibroblast cell lysis.

    PubMed

    Uawonggul, Nunthawun; Chaveerach, Arunrat; Thammasirirak, Sompong; Arkaravichien, Tarinee; Chuachan, Chattong; Daduang, Sakda

    2006-01-16

    The aqueous extracts of 64 plant species, listed as animal- or insect-bite antidotes in old Thai drug recipes were screened for their activity against fibroblast cell lysis after Heterometrus laoticus scorpion venom treatment. The venom was preincubated with plant extract for 30 min and furthered treated to confluent fibroblast cells for 30 min. More than 40% efficiency (test/control) was obtained from cell treatment with venom preincubated with extracts of Andrographis paniculata Nees (Acanthaceae), Barringtonia acutangula (L.) Gaertn. (Lecythidaceae), Calamus sp. (Palmae), Clinacanthus nutans Lindau (Acanthaceae), Euphorbia neriifolia L. (Euphorbiaceae), Ipomoea aquatica Forssk (Convolvulaceae), Mesua ferrea L. (Guttiferae), Passiflora laurifolia L. (Passifloraceae), Plectranthus amboinicus (Lour.) Spreng. (Labiatae), Ricinus communis L. (Euphorbiaceae), Rumex sp. (Polygonaceae) and Sapindus rarak DC. (Sapindaceae), indicating that they had a tendency to be scorpion venom antidotes. However, only Andrographis paniculata and Barringtonia acutangula extracts provided around 50% viable cells from extract treatments without venom preincubation. These two plant extracts are expected to be scorpion venom antidotes with low cytotoxicity.

  12. Privacy Act

    EPA Pesticide Factsheets

    Learn about the Privacy Act of 1974, the Electronic Government Act of 2002, the Federal Information Security Management Act, and other information about the Environmental Protection Agency maintains its records.

  13. Transcription factors GAF and HSF act at distinct regulatory steps to modulate stress-induced gene activation.

    PubMed

    Duarte, Fabiana M; Fuda, Nicholas J; Mahat, Dig B; Core, Leighton J; Guertin, Michael J; Lis, John T

    2016-08-01

    The coordinated regulation of gene expression at the transcriptional level is fundamental to development and homeostasis. Inducible systems are invaluable when studying transcription because the regulatory process can be triggered instantaneously, allowing the tracking of ordered mechanistic events. Here, we use precision run-on sequencing (PRO-seq) to examine the genome-wide heat shock (HS) response in Drosophila and the function of two key transcription factors on the immediate transcription activation or repression of all genes regulated by HS. We identify the primary HS response genes and the rate-limiting steps in the transcription cycle that GAGA-associated factor (GAF) and HS factor (HSF) regulate. We demonstrate that GAF acts upstream of promoter-proximally paused RNA polymerase II (Pol II) formation (likely at the step of chromatin opening) and that GAF-facilitated Pol II pausing is critical for HS activation. In contrast, HSF is dispensable for establishing or maintaining Pol II pausing but is critical for the release of paused Pol II into the gene body at a subset of highly activated genes. Additionally, HSF has no detectable role in the rapid HS repression of thousands of genes.

  14. Identification of positive-acting domains in GCN2 protein kinase required for translational activation of GCN4 expression

    SciTech Connect

    Wek, R.C.; Ramirez, M.; Jackson, B.M.; Hinnebusch, A.G. )

    1990-06-01

    GCN4 is a transcriptional activator of amino acid-biosynthetic genes in the yeast {ital Saccharomyces cerevisiae}. GCN2, a translational activator of {ital GCN4} expression, contains a domain homologous to the catalytic subunit of eukaryotic protein kinases. Substitution of a highly conserved lysine residue in the kinase domain abolished GCN2 regulatory function in vivo and its ability to autophosphorylate in vitro, indicating that GCN2 acts as a protein kinase in stimulating {ital GCN4} expression. Elevated {ital GCN2} gene dosage led to depression of {ital GCN4} under nonstarvation conditions; however, the authors found that {ital GCN2} mRNA and protein levels did not increase in wild-type cells in response to amino acid starvation. Therefore, it appears that GCN2 protein kinase function is stimulated postranslationally in amino acid-starved cells. Three dominant-constitutive {ital GCN2} point mutations were isolated that led to derepressed {ital GCN4} expression under nonstarvation conditions. Two of the {ital GCN2}(Con) mutations mapped in the kinase domain itself. The third mapped just downstream from a carboxyl-terminal segment homologous to histidyl-tRNA synthetase (HisRS), which the authors suggest might function to detect uncharged tRNA in amino acid-starved cells and activate the adjacent protein kinase moiety.

  15. Histone Methyltransferase Inhibitors Are Orally Bioavailable, Fast-Acting Molecules with Activity against Different Species Causing Malaria in Humans

    PubMed Central

    Sundriyal, Sandeep; Caron, Joachim; Chen, Patty; Witkowski, Benoit; Menard, Didier; Suwanarusk, Rossarin; Renia, Laurent; Nosten, Francois; Jiménez-Díaz, María Belén; Angulo-Barturen, Iñigo; Martínez, María Santos; Ferrer, Santiago; Sanz, Laura M.; Gamo, Francisco-Javier; Wittlin, Sergio; Duffy, Sandra; Avery, Vicky M.; Ruecker, Andrea; Delves, Michael J.; Sinden, Robert E.; Fuchter, Matthew J.

    2014-01-01

    Current antimalarials are under continuous threat due to the relentless development of drug resistance by malaria parasites. We previously reported promising in vitro parasite-killing activity with the histone methyltransferase inhibitor BIX-01294 and its analogue TM2-115. Here, we further characterize these diaminoquinazolines for in vitro and in vivo efficacy and pharmacokinetic properties to prioritize and direct compound development. BIX-01294 and TM2-115 displayed potent in vitro activity, with 50% inhibitory concentrations (IC50s) of <50 nM against drug-sensitive laboratory strains and multidrug-resistant field isolates, including artemisinin-refractory Plasmodium falciparum isolates. Activities against ex vivo clinical isolates of both P. falciparum and Plasmodium vivax were similar, with potencies of 300 to 400 nM. Sexual-stage gametocyte inhibition occurs at micromolar levels; however, mature gametocyte progression to gamete formation is inhibited at submicromolar concentrations. Parasite reduction ratio analysis confirms a high asexual-stage rate of killing. Both compounds examined displayed oral efficacy in in vivo mouse models of Plasmodium berghei and P. falciparum infection. The discovery of a rapid and broadly acting antimalarial compound class targeting blood stage infection, including transmission stage parasites, and effective against multiple malaria-causing species reveals the diaminoquinazoline scaffold to be a very promising lead for development into greatly needed novel therapies to control malaria. PMID:25421480

  16. β-Glucuronidase activity and mitochondrial dysfunction: the sites where flavonoid glucuronides act as anti-inflammatory agents.

    PubMed

    Kawai, Yoshichika

    2014-05-01

    Epidemiological and experimental studies suggest that the consumption of flavonoid-rich diets decreases the risk of various chronic diseases such as cardiovascular diseases. Although studies on the bioavailability of flavonoids have been well-characterized, the tissue and cellular localizations underlying their biological mechanisms are largely unknown. The development and application of novel monoclonal antibodies revealed that macrophages could be the major target of dietary flavonoids in vivo. Using macrophage-like cell lines in vitro, we examined the molecular basis of the interaction between the macrophages and flavonoids, especially the glucuronide metabolites. We have found that extracellular β-glucuronidase secreted from macrophages is essential for the bioactivation of the glucuronide conjugates into the aglycone, and that the enzymatic activity, which requires an acidic pH, is promoted by the increased secretion of lactate in response to the mitochondrial dysfunction. This review describes our recent findings indicating the molecular mechanisms responsible for the anti-inflammatory activity of dietary flavonoids within the inflammation sites. We propose that the extracellular activity of β-glucuronidase associated with the status of the mitochondrial function in the target cells might be important biomarkers for the specific sites where the glucuronides of dietary flavonoids can act as anti-atherosclerotic and anti-inflammatory agents in vivo.

  17. 45 CFR 90.3 - What programs or activities does the Age Discrimination Act of 1975 cover?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Assistance Act of 1972 (31 U.S.C. 1221 et seq.). (b) The Age Discrimination Act of 1975 does not apply to: (1... employment under the Comprehensive Employment and Training Act of 1974 (CETA), (29 U.S.C. 801 et seq.)....

  18. Preparing Principals for Success with English Language Learners: Challenges and Opportunities in Illinois

    ERIC Educational Resources Information Center

    Reeves, Alison; Van Tuyle, Vicki

    2014-01-01

    This paper explores the challenges and opportunities of the English Language Learner (ELL) components of Illinois' new principal preparation legislation [Illinois Public Act 96-0903]. In 2011, Illinois passed Illinois Public Act 96-0903 creating new rules for principal preparation programs requiring institutions or organizations certifying…

  19. The Effect of Instruction on Learners' Pragmatic Awareness: A Focus on Refusals

    ERIC Educational Resources Information Center

    Soler, Eva Alcon; Pitarch, Josep Guzman

    2010-01-01

    The benefits of instruction on learners' production and awareness of speech acts is well documented (see Alcon and Martinez-Flor, 2008, for a review of pragmatics in instructional contexts). However, few studies examine the influence that instruction may have on the cognitive processes involved in speech act production (Felix-Brasdefer, 2008). In…

  20. An Attempt to Raise Japanese EFL Learners' Pragmatic Awareness Using Online Discourse Completion Tasks

    ERIC Educational Resources Information Center

    Tanaka, Hiroya; Oki, Nanaho

    2015-01-01

    This practical paper discusses the effect of explicit instruction to raise Japanese EFL learners' pragmatic awareness using online discourse completion tasks. The five-part tasks developed by the authors use American TV drama scenes depicting particular speech acts and include explicit instruction in these speech acts. 46 Japanese EFL college…

  1. Learning Difficulties in English for Rural Learners

    ERIC Educational Resources Information Center

    Singaravelu, G.

    2010-01-01

    The present study illuminates and diagnoses the learning problems of the rural learners in English Grammar at standard VI. Present study may be useful to ameliorate the rural learners for acquiring competencies in English and eliminates the problems of the learners. It paves way to the teachers to diagnose the learning hurdles of the learners and…

  2. Model Learner Outcomes for Service Occupations.

    ERIC Educational Resources Information Center

    Grote, Audrey M.

    This guide to model learner outcomes for service occupations contains four chapters: (1) education values, learner values, philosophy, mission, and goals; (2) introduction, goals, and eight program-level learner outcomes; (3) general learner outcomes and outcomes for housing occupations, child care occupations, cosmetology and personal services,…

  3. Preparing Learners for e-Learning.

    ERIC Educational Resources Information Center

    Piskurich, George M., Ed.

    This book presents methods business organizations and educational institutions can use to prepare their learners to become successful e-learners. "Preparing e-Learners for Self- Directed Learning" (Long) discusses self-direction as a prerequisite to e-learning and gives a list of ways to help enhance learners' self-directedness.…

  4. Integrated Application of Active Controls (IAAC) technology to an advanced subsonic transport project: Current and advanced act control system definition study. Volume 2: Appendices

    NASA Technical Reports Server (NTRS)

    Hanks, G. W.; Shomber, H. A.; Dethman, H. A.; Gratzer, L. B.; Maeshiro, A.; Gangsaas, D.; Blight, J. D.; Buchan, S. M.; Crumb, C. B.; Dorwart, R. J.

    1981-01-01

    The current status of the Active Controls Technology (ACT) for the advanced subsonic transport project is investigated through analysis of the systems technical data. Control systems technologies under examination include computerized reliability analysis, pitch axis fly by wire actuator, flaperon actuation system design trade study, control law synthesis and analysis, flutter mode control and gust load alleviation analysis, and implementation of alternative ACT systems. Extensive analysis of the computer techniques involved in each system is included.

  5. Annual Report to the President and the Congress Fiscal Year 1985 on Federal Activities Related to the Administration of the Rehabilitation Act of 1973 as Amended.

    ERIC Educational Resources Information Center

    Rehabilitation Services Administration (ED), Washington, DC.

    This report describes program activities related to the administration of the Rehabilitation Act of 1973 from October 1, 1984 through September 30, 1985. Information is presented on funding efforts, program development, and other activities relating to: vocational rehabilitation services (e.g., American Indian vocational rehabilitation services,…

  6. Access, Consider, Teach: ACT in Your Classroom

    ERIC Educational Resources Information Center

    Stanford, Pokey; Reeves, Stacy

    2007-01-01

    University teachers who are teacher educators cannot connect to "The Millennial Generation" of today's preservice learners by using chalk and dull outdated textbooks. When university professionals access the technology available, consider the curriculum, and teach with technology (ACT) undergraduate teacher candidates acquire the vision of…

  7. Insulin acts in the arcuate nucleus to increase lumbar sympathetic nerve activity and baroreflex function in rats

    PubMed Central

    Cassaglia, Priscila A; Hermes, Sam M; Aicher, Sue A; Brooks, Virginia L

    2011-01-01

    Abstract Although the central effects of insulin to activate the sympathetic nervous system and enhance baroreflex gain are well known, the specific brain site(s) at which insulin acts has not been identified. We tested the hypotheses that (1) the paraventricular nucleus of the hypothalamus (PVN) and the arcuate nucleus (ArcN) are necessary brain sites and (2) insulin initiates its effects directly in the PVN and/or the ArcN. In α-chloralose anaesthetised female Sprague–Dawley rats, mean arterial pressure (MAP), heart rate (HR) and lumbar sympathetic nerve activity (LSNA) were recorded continuously, and baroreflex gain of HR and LSNA were measured before and during a hyperinsulinaemic–euglycaemic clamp. After 60 min, intravenous infusion of insulin (15 mU kg−1 min−1), but not saline, significantly increased (P < 0.05) basal LSNA (to 228 ± 28% control) and gain of baroreflex control of LSNA (from 3.8 ± 1.1 to 7.4 ± 2.4% control mmHg−1). These effects were reversed (P < 0.05) by local inhibition (bilateral microinjection of musimol) of the PVN (LSNA to 124 ± 8.8% control; LSNA gain to 3.9 ± 1.7% control mmHg−1) or of the ArcN (LSNA in % control: from 100 ± 0 to 198 ± 24 (insulin), then 133 ± 23 (muscimol) LSNA gain in % control mmHg−1: from 3.9 ± 0.3 to 8.9 ± 0.9 (insulin), then 5.1 ± 0.5 (muscimol)). While insulin receptor immunoreactivity was identified in neurons in pre-autonomic PVN subnuclei, microinjection of insulin (0.6, 6 and 60 nU) into the PVN failed to alter LSNA or LSNA gain. However, ArcN insulin increased (P < 0.05) basal LSNA (in % control to 162 ± 19, 0.6 nU; 193 ± 19, 6 nU; and 205 ± 28, 60 nU) and LSNA baroreflex gain (in % control mmHg−1 from 4.3 ± 1.2 to 6.9 ± 1.0, 0.6 nU; 7.7 ± 1.2, 6 nU; and 7.8 ± 1.3, 60 nU). None of the treatments altered MAP, HR, or baroreflex control of HR. Our findings identify the ArcN as the site at which insulin acts to activate the sympathetic nervous system and increase baroreflex

  8. Clobetasol and Halcinonide Act as Smoothened Agonists to Promote Myelin Gene Expression and RxRγ Receptor Activation

    PubMed Central

    De Nardis, Velia; Di Giandomenico, Daniele; Lucisano, Giuseppe; Scardapane, Marco; Poma, Anna; Ragnini-Wilson, Antonella

    2015-01-01

    One of the causes of permanent disability in chronic multiple sclerosis patients is the inability of oligodendrocyte progenitor cells (OPCs) to terminate their maturation program at lesions. To identify key regulators of myelin gene expression acting at the last stages of OPC maturation we developed a drug repositioning strategy based on the mouse immortalized oligodendrocyte (OL) cell line Oli-neu brought to the premyelination stage by stably expressing a key factor regulating the last stages of OL maturation. The Prestwick Chemical Library® of 1,200 FDA-approved compound(s) was repositioned at three dosages based on the induction of Myelin Basic Protein (MBP) expression. Drug hits were further validated using dosage-dependent reproducibility tests and biochemical assays. The glucocorticoid class of compounds was the most highly represented and we found that they can be divided in three groups according to their efficacy on MBP up-regulation. Since target identification is crucial before bringing compounds to the clinic, we searched for common targets of the primary screen hits based on their known chemical-target interactomes, and the pathways predicted by top ranking compounds were validated using specific inhibitors. Two of the top ranking compounds, Halcinonide and Clobetasol, act as Smoothened (Smo) agonists to up-regulate myelin gene expression in the Oli-neuM cell line. Further, RxRγ activation is required for MBP expression upon Halcinonide and Clobetasol treatment. These data indicate Clobetasol and Halcinonide as potential promyelinating drugs and also provide a mechanistic understanding of their mode of action in the pathway leading to myelination in OPCs. Furthermore, our classification of glucocorticoids with respect to MBP expression provides important novel insights into their effects in the CNS and a rational criteria for their choice in combinatorial therapies in de-myelinating diseases. PMID:26658258

  9. Clobetasol and Halcinonide Act as Smoothened Agonists to Promote Myelin Gene Expression and RxRγ Receptor Activation.

    PubMed

    Porcu, Giampiero; Serone, Eliseo; De Nardis, Velia; Di Giandomenico, Daniele; Lucisano, Giuseppe; Scardapane, Marco; Poma, Anna; Ragnini-Wilson, Antonella

    2015-01-01

    One of the causes of permanent disability in chronic multiple sclerosis patients is the inability of oligodendrocyte progenitor cells (OPCs) to terminate their maturation program at lesions. To identify key regulators of myelin gene expression acting at the last stages of OPC maturation we developed a drug repositioning strategy based on the mouse immortalized oligodendrocyte (OL) cell line Oli-neu brought to the premyelination stage by stably expressing a key factor regulating the last stages of OL maturation. The Prestwick Chemical Library of 1,200 FDA-approved compound(s) was repositioned at three dosages based on the induction of Myelin Basic Protein (MBP) expression. Drug hits were further validated using dosage-dependent reproducibility tests and biochemical assays. The glucocorticoid class of compounds was the most highly represented and we found that they can be divided in three groups according to their efficacy on MBP up-regulation. Since target identification is crucial before bringing compounds to the clinic, we searched for common targets of the primary screen hits based on their known chemical-target interactomes, and the pathways predicted by top ranking compounds were validated using specific inhibitors. Two of the top ranking compounds, Halcinonide and Clobetasol, act as Smoothened (Smo) agonists to up-regulate myelin gene expression in the Oli-neuM cell line. Further, RxRγ activation is required for MBP expression upon Halcinonide and Clobetasol treatment. These data indicate Clobetasol and Halcinonide as potential promyelinating drugs and also provide a mechanistic understanding of their mode of action in the pathway leading to myelination in OPCs. Furthermore, our classification of glucocorticoids with respect to MBP expression provides important novel insights into their effects in the CNS and a rational criteria for their choice in combinatorial therapies in de-myelinating diseases.

  10. Flagellin acting via TLR5 is the major activator of key signaling pathways leading to NF-κB and proinflammatory gene program activation in intestinal epithelial cells

    PubMed Central

    Tallant, Thomas; Deb, Amitabha; Kar, Niladri; Lupica, Joseph; de Veer, Michael J; DiDonato, Joseph A

    2004-01-01

    Background Infection of intestinal epithelial cells by pathogenic Salmonella leads to activation of signaling cascades that ultimately initiate the proinflammatory gene program. The transcription factor NF-κB is a key regulator/activator of this gene program and is potently activated. We explored the mechanism by which Salmonella activates NF-κB during infection of cultured intestinal epithelial cells and found that flagellin produced by the bacteria and contained on them leads to NF-κB activation in all the cells; invasion of cells by the bacteria is not required to activate NF-κB. Results Purified flagellin activated the mitogen activated protein kinase (MAPK), stress-activated protein kinase (SAPK) and Ikappa B kinase (IKK) signaling pathways that lead to expression of the proinflammatory gene program in a temporal fashion nearly identical to that of infection of intestinal epithelial cells by Salmonella. Flagellin expression was required for Salmonella invasion of host cells and it activated NF-κB via toll-like receptor 5 (TLR5). Surprisingly, a number of cell lines found to be unresponsive to flagellin express TLR5 and expression of exogenous TLR5 in these cells induces NF-κB activity in response to flagellin challenge although not robustly. Conversely, overexpression of dominant-negative TLR5 alleles only partially blocks NF-κB activation by flagellin. These observations are consistent with the possibility of either a very stable TLR5 signaling complex, the existence of a low abundance flagellin co-receptor or required adapter, or both. Conclusion These collective results provide the evidence that flagellin acts as the main determinant of Salmonella mediated NF-κB and proinflammatory signaling and gene activation by this flagellated pathogen. In addition, expression of the fli C gene appears to play an important role in the proper functioning of the TTSS since mutants that fail to express fli C are defective in expressing a subset of Sip proteins and

  11. Acetylcholine acts through M3 muscarinic receptor to activate the EGFR signaling and promotes gastric cancer cell proliferation

    PubMed Central

    Yu, Huangfei; Xia, Hongwei; Tang, Qiulin; Xu, Huanji; Wei, Guoqing; Chen, Ying; Dai, Xinyu; Gong, Qiyong; Bi, Feng

    2017-01-01

    Acetylcholine (ACh), known as a neurotransmitter, regulates the functions of numerous fundamental central and peripheral nervous system. Recently, emerging evidences indicate that ACh also plays an important role in tumorigenesis. However, little is known about the role of ACh in gastric cancer. Here, we reported that ACh could be auto-synthesized and released from MKN45 and BGC823 gastric cancer cells. Exogenous ACh promoted cell proliferation in a does-dependent manner. The M3R antagonist 4-DAMP, but not M1R antagonist trihexyphenidyl and M2/4 R antagonist AFDX-116, could reverse the ACh-induced cell proliferation. Moreover, ACh, via M3R, activated the EGFR signaling to induce the phosphorylation of ERK1/2 and AKT, and blocking EGFR pathway by specific inhibitor AG1478 suppressed the ACh induced cell proliferation. Furthermore, the M3R antagonist 4-DAMP and darifenacin could markedly inhibit gastric tumor formation in vivo. 4-DAMP could also significantly enhance the cytotoxic activity of 5-Fu against the MKN45 and BGC823 cells, and induce the expression of apoptosis-related proteins such as Bax and Caspase-3. Together, these findings indicated that the autocrine ACh could act through M3R and the EGFR signaling to promote gastric cancer cells proliferation, targeting M3R or EGFR may provide us a potential therapeutic strategy for gastric cancer treatment. PMID:28102288

  12. Eps15 membrane-binding and -bending activity acts redundantly with Fcho1 during clathrin-mediated endocytosis

    PubMed Central

    Wang, Lei; Johnson, Adam; Hanna, Michael; Audhya, Anjon

    2016-01-01

    Clathrin coat assembly on membranes requires cytosolic adaptors and accessory proteins, which bridge triskeleons with the lipid bilayer and stabilize lattice architecture throughout the process of vesicle formation. In Caenorhabditis elegans, the prototypical AP-2 adaptor complex, which is activated by the accessory factor Fcho1 at the plasma membrane, is dispensable during embryogenesis, enabling us to define alternative mechanisms that facilitate clathrin-mediated endocytosis. Here we uncover a synthetic genetic interaction between C. elegans Fcho1 (FCHO-1) and Eps15 (EHS-1), suggesting that they function in a parallel and potentially redundant manner. Consistent with this idea, we find that the FCHO-1 EFC/F-BAR domain and the EHS-1 EH domains exhibit highly similar membrane-binding and -bending characteristics in vitro. Furthermore, we demonstrate a critical role for EHS-1 when FCHO-1 membrane-binding and -bending activity is specifically eliminated in vivo. Taken together, our data highlight Eps15 as an important membrane-remodeling factor, which acts in a partially redundant manner with Fcho proteins during the earliest stages of clathrin-mediated endocytosis. PMID:27385343

  13. DCA1 Acts as a Transcriptional Co-activator of DST and Contributes to Drought and Salt Tolerance in Rice.

    PubMed

    Cui, Long-Gang; Shan, Jun-Xiang; Shi, Min; Gao, Ji-Ping; Lin, Hong-Xuan

    2015-10-01

    Natural disasters, including drought and salt stress, seriously threaten food security. In previous work we cloned a key zinc finger transcription factor gene, Drought and Salt Tolerance (DST), a negative regulator of drought and salt tolerance that controls stomatal aperture in rice. However, the exact mechanism by which DST regulates the expression of target genes remains unknown. In the present study, we demonstrated that DST Co-activator 1 (DCA1), a previously unknown CHY zinc finger protein, acts as an interacting co-activator of DST. DST was found to physically interact with itself and to form a heterologous tetramer with DCA1. This transcriptional complex appears to regulate the expression of peroxidase 24 precursor (Prx 24), a gene encoding an H2O2 scavenger that is more highly expressed in guard cells. Downregulation of DCA1 significantly enhanced drought and salt tolerance in rice, and overexpression of DCA1 increased sensitivity to stress treatment. These phenotypes were mainly influenced by DCA1 and negatively regulated stomatal closure through the direct modulation of genes associated with H2O2 homeostasis. Our findings establish a framework for plant drought and salt stress tolerance through the DCA1-DST-Prx24 pathway. Moreover, due to the evolutionary and functional conservation of DCA1 and DST in plants, engineering of this pathway has the potential to improve tolerance to abiotic stress in other important crop species.

  14. The Relationship between Psychosocial Correlates and Physical Activity in Underserved Adolescent Boys and Girls in the ACT Trial

    PubMed Central

    Lawman, Hannah G.; Wilson, Dawn K.; Van Horn, M. Lee; Resnicow, Ken; Kitzman-Ulrich, Heather

    2011-01-01

    Background Previous research suggests motivation, enjoyment, and self-efficacy may be important psychosocial factors for understanding physical activity (PA) in youth. While previous studies have shown mixed results, emerging evidence indicates relationships between psychosocial factors and PA may be stronger in boys than girls. This study expands on previous research by examining the effects of motivation, enjoyment and self-efficacy on PA in underserved adolescent (low income, ethnic minorities) boys and girls. Based on previous literature, it was hypothesized the effects of motivation, enjoyment and self-efficacy on moderate-to-vigorous PA (MVPA) would be stronger in boys than in girls. Methods Baseline cross-sectional data were obtained from a randomized, school-based trial (Active by Choice Today; ACT) in underserved 6th graders (N=771 girls, 651 boys). Intrapersonal variables for PA were assessed via self-report and confirmatory factor analyses were conducted for each predictor. MVPA was assessed with 7-day accelerometry estimates. Results Multivariate regression analyses stratified by sex demonstrated a significant positive main effect of self-efficacy and motivation on MVPA for girls. Boys also showed a positive trend for the effect of motivation on MVPA. Conclusions The results from this study suggest motivation and self-efficacy should be better integrated to facilitate the development of more effective interventions for increasing PA in underserved adolescents. PMID:21359129

  15. 7alpha-Hydroxypregnenolone acts as a neuronal activator to stimulate locomotor activity of breeding newts by means of the dopaminergic system.

    PubMed

    Matsunaga, Masahiro; Ukena, Kazuyoshi; Baulieu, Etienne-Emile; Tsutsui, Kazuyoshi

    2004-12-07

    It is becoming clear that steroids can be synthesized de novo by the brain and other nervous systems. Such steroids are called neurosteroids, and de novo neurosteroidogenesis from cholesterol is a conserved property of vertebrate brains. In this study, we show that the newt brain actively produces 7alpha-hydroxypregnenolone, a previously undescribed amphibian neurosteroid that stimulates locomotor activity. 7alpha-hydroxypregnenolone was identified as a most abundant amphibian neurosteroid in the newt brain by using biochemical techniques combined with HPLC, TLC, and GC-MS analyses. The production of 7alpha-hydroxypregnenolone in the diencephalon and rhombencephalon was higher than that in the telencephalon and peripheral steroidogenic glands. In addition, 7alpha-hydroxypregnenolone synthesis in the brain showed marked changes during the annual breeding cycle, with a maximal level in the spring breeding period when locomotor activity of the newt increases. Behavioral analysis of newts in the nonbreeding period demonstrated that administration of this previously undescribed amphibian neurosteroid acutely increased locomotor activity. In vitro analysis further revealed that 7alpha-hydroxypregnenolone treatment resulted in a dose-dependent increase in the release of dopamine from cultured brain tissue of nonbreeding newts. The effect of this neurosteroid on locomotion also was abolished by dopamine D(2)-like receptor antagonists. These results indicate that 7alpha-hydroxypregnenolone acts as a neuronal activator to stimulate locomotor activity of breeding newts through the dopaminergic system. This study demonstrates a physiological function of 7alpha-hydroxypregnenolone that has not been described previously in any vertebrate class. This study also provides findings on the regulatory mechanism of locomotor activity from a unique standpoint.

  16. The Rice Transcription Factor WRKY53 Suppresses Herbivore-Induced Defenses by Acting as a Negative Feedback Modulator of Mitogen-Activated Protein Kinase Activity1

    PubMed Central

    Hu, Lingfei; Ye, Meng; Zhang, Tongfang; Zhou, Guoxin; Wang, Qi; Lu, Jing

    2015-01-01

    The mechanisms by which herbivore-attacked plants activate their defenses are well studied. By contrast, little is known about the regulatory mechanisms that allow them to control their defensive investment and avoid a defensive overshoot. We characterized a rice (Oryza sativa) WRKY gene, OsWRKY53, whose expression is rapidly induced upon wounding and induced in a delayed fashion upon attack by the striped stem borer (SSB) Chilo suppressalis. The transcript levels of OsWRKY53 are independent of endogenous jasmonic acid but positively regulated by the mitogen-activated protein kinases OsMPK3/OsMPK6. OsWRKY53 physically interacts with OsMPK3/OsMPK6 and suppresses their activity in vitro. By consequence, it modulates the expression of defensive, MPK-regulated WRKYs and thereby reduces jasmonic acid, jasmonoyl-isoleucine, and ethylene induction. This phytohormonal reconfiguration is associated with a reduction in trypsin protease inhibitor activity and improved SSB performance. OsWRKY53 is also shown to be a negative regulator of plant growth. Taken together, these results show that OsWRKY53 functions as a negative feedback modulator of MPK3/MPK6 and thereby acts as an early suppressor of induced defenses. OsWRKY53 therefore enables rice plants to control the magnitude of their defensive investment during early signaling. PMID:26453434

  17. Active ingredients in sunscreens act as topical penetration enhancers for the herbicide 2,4-dichlorophenoxyacetic acid.

    PubMed

    Pont, Adam R; Charron, Anna R; Brand, Rhonda M

    2004-03-15

    Agricultural workers are encouraged to use sunscreen to decrease the risk of UV-related skin cancer. Our previous studies have shown certain commercial sunscreens to be penetration enhancers. The focus of this project is to determine whether active ingredients in sunscreen formulations (i.e., the UV absorbing components and insect repellants for the sunscreen/bug repellant combinations) also act as dermal penetration enhancers for herbicides in vitro. The total percentages of 2,4-dichlorophenoxyacetic acid (2,4-D) penetrating through hairless mouse skin in 24 h ranged from 54.9 +/- 4.7 for the no sunscreen control to 86.9 +/- 2.5 for padimate-o. Of the active ingredients tested (7.5% octyl methoxycinnamate, 7% octocrylene, 0.6% oxybenzone, 5% homosalate, 5% octyl salicylate, 8% padimate-o, 10% sulisobenzone, and 9.5% and 19% N,N-diethyl-m-toluamide [DEET]), all but octocrylene led to a significant increase in total 2,4-D penetration as compared to the control (P < 0.05), and only octocrylene and oxybenzone did not significantly decrease the corresponding lag time. Octyl salicylate (P < 0.01) and octyl methoxycinnimate (P < 0.05) significantly increased the 3H2O penetration across mouse skin, indicating physical damage to the stratum corneum. Additional studies demonstrated that the penetration enhancement seen across hairless mouse skin also occurred with human skin. Thus, the active ingredients of sunscreen formulations enhance dermal penetration of the moderately lipophilic herbicide 2,4-D.

  18. Galectin-3 and soluble fibrinogen act in concert to modulate neutrophil activation and survival: involvement of alternative MAPK pathways.

    PubMed

    Fernández, Gabriela C; Ilarregui, Juan M; Rubel, Carolina J; Toscano, Marta A; Gómez, Sonia A; Beigier Bompadre, Macarena; Isturiz, Martín A; Rabinovich, Gabriel A; Palermo, Marina S

    2005-05-01

    Galectin-3 (Gal-3), a member of a family of highly conserved carbohydrate-binding proteins, has recently emerged as a novel cellular modulator at inflammatory foci. Here we investigated the effects of Gal-3 on central effector functions of human neutrophils, including phagocytosis, exocytosis of secretory granules, and survival. We examined the effects of Gal-3 alone or in combination with soluble fibrinogen (sFbg), an extracellular mediator that plays a key role during the early phase of the inflammatory response through binding to integrin receptors. In addition we evaluated the intracellular signals triggered by these mediators in human neutrophils. Human neutrophils incubated with recombinant Gal-3 alone increased their phagocytic activity and CD66 surface expression. In contrast to the known antiapoptotic effect of Gal-3 on many cellular types, Gal-3 enhanced PMN apoptotic rate. Preincubation with Gal-3 primed neutrophils to the effects of sFbg, resulting in a synergistic action on degranulation. On the other hand, Gal-3 and sFbg had opposite effects on PMN survival, and the simultaneous action of both agonists partially counteracted the proapoptotic effects of Gal-3. In addition, although sFbg induced its effects through the activation of the ERKs, Gal-3 led to p38 phosphorylation. Disruption of this signaling pathway abrogated Gal-3-mediated modulation of neutrophil degranulation, phagocytosis, and apoptosis. Together, our results support the notion that Gal-3 and sFbg are two physiological mediators present at inflammatory sites that activate different components of the MAPK pathway and could be acting in concert to modulate the functionality and life span of neutrophils.

  19. [Characteristics of antagonism between ceruletide and various central-acting drugs: investigation by means of ambulatory activity in mice].

    PubMed

    Ida, I; Asami, T; Kuribara, H; Machiyama, Y; Tadokoro, S

    1990-12-01

    Behavioral characteristics of ceruletide, a cholecystokinin-like decapeptide, were investigated by means of ambulatory activity in mice. Ceruletide at 100 and 300 micrograms/kg, i.p. slightly but significantly decreased the mouse's activity for 20 min. Therefore, 100 micrograms/kg of ceruletide was used in the experiment of combined administration with the central-acting drugs. Ceruletide reduced the increased activity which was produced by methamphetamine (2 mg/kg, s.c.), ephedrine (80 mg/kg, i.p.), methylphenidate (4 mg/kg, s.c.), cocaine (20 mg/kg, s.c.), mazindol (2.5 mg/kg, s.c.), apomorphine (0.5 mg/kg, s.c.), bromocriptine (8 mg/kg, i.p.), scopolamine (0.5 mg/kg, s.c.), caffeine (10 mg/kg, s.c.) and morphine (20 mg/kg, s.c.) with different potencies and durations. The mice that had experienced ceruletide at 3 micrograms/kg for 5 times at intervals of 3-4 days demonstrated a significant increase in the sensitivity to methamphetamine, although the same treatment with 10-300 micrograms/kg of ceruletide was without effect. On the other hand, when 3-300 micrograms/kg of ceruletide was combined with 2 mg/kg of methamphetamine, the development of reverse tolerance to the ambulation-increasing effect of methamphetamine was inhibited dependently on the doses of ceruletide. However, the reverse tolerance to methamphetamine once established was scarcely modified by ceruletide when it was administered afterwards.

  20. Learner Agency and the Use of Affordances in Language-Exchange Interactions

    ERIC Educational Resources Information Center

    Ahn, Tae youn

    2016-01-01

    Language exchange refers to a learning partnership between two learners with different native languages who collaborate to help each other improve their proficiency in the other's language. The purpose of this study is to examine the ways in which language-exchange participants activate learner agency to construct opportunities for learning in…

  1. A Critical Analysis of Learner Participation in Virtual Worlds: How Can Virtual Worlds Inform Our Pedagogy?

    ERIC Educational Resources Information Center

    Panichi, Luisa

    2015-01-01

    This paper reports on an exploratory case study of learner participation within the context of online language learning in virtual world platforms. Data for this investigation was collected through a case study of a Business English course within a qualitative Case-Study Research framework. This study examines learner activity in virtual worlds in…

  2. "Can We Do That Again?" Engaging Learners and Developing beyond the "Wow" Factor in Science

    ERIC Educational Resources Information Center

    Astall, Chris; Bruce, Warren

    2010-01-01

    Adding Mentos to an open bottle of Diet Coke can produce a fountain of liquid and froth extending several metres high. This activity can engage a wide audience of learners in a relevant and meaningful way, provide a model for creative science teaching, and help to develop learners' attitudes towards school science as a subject. In this paper, the…

  3. A Multi-Perspective Investigation into Learners' Interaction in Asynchronous Computer-Mediated Communication (CMC)

    ERIC Educational Resources Information Center

    Çardak, Çigdem Suzan

    2016-01-01

    This article focusses on graduate level students' interactions during asynchronous CMC activities of an online course about the teaching profession in Turkey. The instructor of the course designed and facilitated a semester-long asynchronous CMC on forum discussions, and investigated the interaction of learners in multiple perspectives: learners'…

  4. The Relationship between Iranian EFL Learners' Self-Regulatory Vocabulary Strategy Use and Their Vocabulary Size

    ERIC Educational Resources Information Center

    Amirian, Seyed Mohammad Reza; Mallahi, Omid; Zaghi, Damoon

    2015-01-01

    Self-regulation is referred to as learners' self-generated ideas and actions which are systematically directed towards achieving educational goals and require learners' active participation in the learning process (Zimmerman & Bandura, 1994). The present study investigated the relationship between Iranian EFL students' self-regulation capacity…

  5. Toward a Unified Modeling of Learner's Growth Process and Flow Theory

    ERIC Educational Resources Information Center

    Challco, Geiser C.; Andrade, Fernando R. H.; Borges, Simone S.; Bittencourt, Ig I.; Isotani, Seiji

    2016-01-01

    Flow is the affective state in which a learner is so engaged and involved in an activity that nothing else seems to matter. In this sense, to help students in the skill development and knowledge acquisition (referred to as learners' growth process) under optimal conditions, the instructional designers should create learning scenarios that favor…

  6. Effectiveness of a Learner-Directed Model for e-Learning

    ERIC Educational Resources Information Center

    Lee, Stella; Barker, Trevor; Kumar, Vivekanandan Suresh

    2016-01-01

    It is a hard task to strike a balance between extents of control a learner exercises and the amount of guidance, active or passive, afforded by the learning environment to guide, support, and motivate the learner. Adaptive systems strive to find the right balance in a spectrum that spans between self-control and system-guidance. They also concern…

  7. Language-Related Computer Use: Focus on Young L2 English Learners in Sweden

    ERIC Educational Resources Information Center

    Sundqvist, Pia; Sylvén, Liss Kerstin

    2014-01-01

    This paper presents findings from a study investigating young English language learners (YELLs) in Sweden in 4th grade (N = 76, aged 10-11). Data were collected with the help of a questionnaire and a one-week language diary. The main purpose was to examine the learners' L2 English language-related activities outside of school in general, and their…

  8. The Interplay between Language, Gestures, Dragging and Diagrams in Bilingual Learners' Mathematical Communications

    ERIC Educational Resources Information Center

    Ng, Oi-Lam

    2016-01-01

    This paper discusses the importance of considering bilingual learners' non-linguistic forms of communication for understanding their mathematical thinking. In particular, I provide a detailed analysis of communication involving a pair of high school bilingual learners during an exploratory activity where a touchscreen-based dynamic geometry…

  9. Guiding Learners into Reengagement through the SCALE Environment: An Empirical Study

    ERIC Educational Resources Information Center

    Verginis, Ilias; Gouli, Evangelia; Gogoulou, Agoritsa; Grigoriadou, Maria

    2011-01-01

    The paper presents the facilities offered by the open learner model maintained in the web-based, adaptive, activity-oriented learning environment SCALE (Supporting Collaboration and Adaptation in a Learning Environment), in order to guide online students who become disengaged and support their reengagement. The open learner model (OLM_SCALE)…

  10. Capitalising on Learner Agency and Group Work in Learning Writing in English as a Foreign Language

    ERIC Educational Resources Information Center

    Lin, Zheng

    2013-01-01

    This study investigates the roles of learner agency and group work in learning writing in English as a foreign language (EFL). Through exploratory and participatory action research, this study examines how learner agency and group work function amidst the activity system of task-based EFL writing, especially how they influence and are influenced…

  11. Learner-Centered Psychological Principles: A Framework for School Redesign and Reform.

    ERIC Educational Resources Information Center

    American Psychological Association, Washington, D.C.

    Educators, concerned with disturbing trends in school failure, are arguing for more learner-centered models of schooling. Such a reform effort requires set principles that emphasize the active and reflective nature of learning and learners; 14 such principles are reported here. The immediate goal of this report is to provide a framework that can…

  12. The Relationship between Reading Proficiency and Reading Strategy Use: A Study of Adult ESL Learners

    ERIC Educational Resources Information Center

    Huang, Jiuhan; Nisbet, Deanna

    2014-01-01

    This article explores the relationship between reading strategy use and reading proficiency among 121 adult ESL learners. Reading strategy use was measured by the SORS, and reading proficiency was determined by the CASAS Reading Test and BEST Literacy Test. Findings of the study reveal that (a) adult ESL learners are active strategies users; (b)…

  13. Choosing to Interact: Exploring the Relationship between Learner Personality, Attitudes, and Tutorial Dialogue Participation

    ERIC Educational Resources Information Center

    Ezen-Can, Aysu; Boyer, Kristy Elizabeth

    2015-01-01

    The tremendous effectiveness of intelligent tutoring systems is due in large part to their interactivity. However, when learners are free to choose the extent to which they interact with a tutoring system, not all learners do so actively. This paper examines a study with a natural language tutorial dialogue system for computer science, in which…

  14. Evoking the Power of Learners

    PubMed Central

    Hotelling, Barbara A.

    2011-01-01

    Our mandate, as Lamaze International childbirth educators, is to assist women in making healthy pregnancy, birth, and parenting choices. Being mindful of health promotion theory and using learning tasks and dialogue education to provide information creates a collaborative Lamaze class where the teacher is the facilitator and the learners are accountable for their learning. This column offers Lamaze educators a deeper understanding of adult learners and our roles in their birth education. PMID:22942625

  15. Chinese English Learners' Strategic Competence.

    PubMed

    Wang, Dianjian; Lai, Hongling; Leslie, Michael

    2015-12-01

    The present study aims to investigate Chinese English learners' ability to use communication strategies (CSs). The subjects are put in a relatively real English referential communication setting and the analyses of the research data show that Chinese English learners, when encountering problems in foreign language (FL) communication, are characterized by the frequent use of substitution, approximation, circumlocution, literal translation, exemplification, word-coinage, repetition, and the infrequent use of cultural-knowledge and paralinguistic CSs. The rare use of paralinguistic strategies is found to be typical of Chinese English learners. The high frequency of literal translation, one first language (L1)-based strategy in our study sample, suggests that FL learners' use of L1-based CSs may depend more upon the developmental stage of their target language than the typology distance between L1 and the target language. The frequency of repetition reveals one fact that the Chinese English learners lack variety and flexibility in their use of CSs. Based on these findings, it was indicated that learners' use of CSs is influenced by a variety of factors, among which the development stage of their interlanguage and their cultural background are identified as two important factors. Some implications are finally suggested for the English foreign language teaching practice in China.

  16. Learners' Satisfaction Level with Online Student Portal as a Support System in an Open and Distance eLearning Environment (ODeL)

    ERIC Educational Resources Information Center

    Secreto, Percia V.; Pamulaklakin, Rhodora L.

    2015-01-01

    Learner support in an open, distance and online learning is defined as "all activities and elements in education that respond to a known learner or group of learners, and which are designed to assist in the cognitive, affective, and systemic realms of the learning process" (Brindley, et. al, 2004). Teaching and tutoring, advising and…

  17. A Learner-led, Discussion-based Elective on Emerging Infectious Disease

    PubMed Central

    2015-01-01

    Objective. To implement a learner-led, discussion-based course aimed at exposing second-year pharmacy learners to the study of emerging infectious diseases from a global health perspective and to assess the role and importance of pharmacists in the management of disease outbreaks. Design. Learners examined literature pertinent to an emerging infectious disease in a 3-credit, discussion-based course and participated in peer discussion led by a designated learner. Instructional materials included journal articles, audio-visual presentations, documentaries, book chapters, movies, newspaper/magazine articles, and other materials. Learning outcomes were measured based on the ability of learners to perform critical thinking and analysis, communicate with their peers, and participate in class discussions. Assessment. The course was offered to 2 consecutive cohorts consisting of 14 and 16 learners, respectively. Overall, every learner in the first cohort achieved a final grade of A for the course. In the second cohort, the overall grade distribution consisted of grades of A, B, and C for the course. Learner evaluations indicated that the active-learning, discussion-based environment significantly enhanced interest in the topic and overall performance in the course. Conclusion. The elective course on emerging infectious diseases provided in-depth exposure to disease topics normally not encountered in the pharmacy curriculum. Learners found the material and format valuable, and the course enhanced their appreciation of infectious diseases, research methodology, critical thinking and analysis, and their roles as pharmacists. PMID:26430268

  18. A Learner-led, Discussion-based Elective on Emerging Infectious Disease.

    PubMed

    Mathias, Clinton

    2015-08-25

    Objective. To implement a learner-led, discussion-based course aimed at exposing second-year pharmacy learners to the study of emerging infectious diseases from a global health perspective and to assess the role and importance of pharmacists in the management of disease outbreaks. Design. Learners examined literature pertinent to an emerging infectious disease in a 3-credit, discussion-based course and participated in peer discussion led by a designated learner. Instructional materials included journal articles, audio-visual presentations, documentaries, book chapters, movies, newspaper/magazine articles, and other materials. Learning outcomes were measured based on the ability of learners to perform critical thinking and analysis, communicate with their peers, and participate in class discussions. Assessment. The course was offered to 2 consecutive cohorts consisting of 14 and 16 learners, respectively. Overall, every learner in the first cohort achieved a final grade of A for the course. In the second cohort, the overall grade distribution consisted of grades of A, B, and C for the course. Learner evaluations indicated that the active-learning, discussion-based environment significantly enhanced interest in the topic and overall performance in the course. Conclusion. The elective course on emerging infectious diseases provided in-depth exposure to disease topics normally not encountered in the pharmacy curriculum. Learners found the material and format valuable, and the course enhanced their appreciation of infectious diseases, research methodology, critical thinking and analysis, and their roles as pharmacists.

  19. Foxa2 acts as a co-activator potentiating expression of the Nurr1-induced DA phenotype via epigenetic regulation.

    PubMed

    Yi, Sang-Hoon; He, Xi-Biao; Rhee, Yong-Hee; Park, Chang-Hwan; Takizawa, Takumi; Nakashima, Kinichi; Lee, Sang-Hun

    2014-02-01

    Understanding how dopamine (DA) phenotypes are acquired in midbrain DA (mDA) neuron development is important for bioassays and cell replacement therapy for mDA neuron-associated disorders. Here, we demonstrate a feed-forward mechanism of mDA neuron development involving Nurr1 and Foxa2. Nurr1 acts as a transcription factor for DA phenotype gene expression. However, Nurr1-mediated DA gene expression was inactivated by forming a protein complex with CoREST, and then recruiting histone deacetylase 1 (Hdac1), an enzyme catalyzing histone deacetylation, to DA gene promoters. Co-expression of Nurr1 and Foxa2 was established in mDA neuron precursor cells by a positive cross-regulatory loop. In the presence of Foxa2, the Nurr1-CoREST interaction was diminished (by competitive formation of the Nurr1-Foxa2 activator complex), and CoREST-Hdac1 proteins were less enriched in DA gene promoters. Consequently, histone 3 acetylation (H3Ac), which is responsible for open chromatin structures, was strikingly increased at DA phenotype gene promoters. These data establish the interplay of Nurr1 and Foxa2 as the crucial determinant for DA phenotype acquisition during mDA neuron development.

  20. Diverse activities of viral cis-acting RNA regulatory elements revealed using multicolor, long-term, single-cell imaging.

    PubMed

    Pocock, Ginger M; Zimdars, Laraine L; Yuan, Ming; Eliceiri, Kevin W; Ahlquist, Paul; Sherer, Nathan M

    2017-02-01

    Cis-acting RNA structural elements govern crucial aspects of viral gene expression. How these structures and other posttranscriptional signals affect RNA trafficking and translation in the context of single cells is poorly understood. Herein we describe a multicolor, long-term (>24 h) imaging strategy for measuring integrated aspects of viral RNA regulatory control in individual cells. We apply this strategy to demonstrate differential mRNA trafficking behaviors governed by RNA elements derived from three retroviruses (HIV-1, murine leukemia virus, and Mason-Pfizer monkey virus), two hepadnaviruses (hepatitis B virus and woodchuck hepatitis virus), and an intron-retaining transcript encoded by the cellular NXF1 gene. Striking behaviors include "burst" RNA nuclear export dynamics regulated by HIV-1's Rev response element and the viral Rev protein; transient aggregations of RNAs into discrete foci at or near the nuclear membrane triggered by multiple elements; and a novel, pulsiform RNA export activity regulated by the hepadnaviral posttranscriptional regulatory element. We incorporate single-cell tracking and a data-mining algorithm into our approach to obtain RNA element-specific, high-resolution gene expression signatures. Together these imaging assays constitute a tractable, systems-based platform for studying otherwise difficult to access spatiotemporal features of viral and cellular gene regulation.

  1. SET1 and p300 Act Synergistically, through Coupled Histone Modifications, in Transcriptional Activation by p53

    PubMed Central

    Tang, Zhanyun; Chen, Wei-Yi; Shimada, Miho; Nguyen, Uyen T.T.; Kim, Jaehoon; Sun, Xiao-Jian; Sengoku, Toru; McGinty, Robert K.; Fernandez, Joseph P.; Muir, Tom W.; Roeder, Robert G.

    2014-01-01

    SUMMARY The H3K4me3 mark in chromatin is closely correlated with actively transcribed genes, although the mechanisms involved in its generation and function are not fully understood. In vitro studies with recombinant chromatin and purified human factors demonstrate a robust SET1 complex (SET1C)-mediated H3K4 trimethylation that is dependent upon p53- and p300-mediated H3 acetylation, a corresponding SET1C-mediated enhancement of p53- and p300-dependent transcription that reflects a primary effect of SET1C through H3K4 trimethylation, and direct SET1C-p53 and SET1C-p300 interactions indicative of a targeted recruitment mechanism. Complementary cell-based assays demonstrate a DNA-damage-induced p53-SET1C interaction, a corresponding enrichment of SET1C and H3K4me3 on a p53 target gene (p21/WAF1), and a corresponding codependency of H3K4 trimethylation and transcription upon p300 and SET1C. These results establish a mechanism in which SET1C and p300 act cooperatively, through direct interactions and coupled histone modifications, to facilitate the function of p53. PMID:23870121

  2. Factors Associated with Implementation of the South Carolina Students Health and Fitness Act of 2005: Elementary School Principals' and Physical Activity Directors' Ratings

    ERIC Educational Resources Information Center

    Evans, Miriam Jones

    2012-01-01

    This study explores factors associated with implementation of the physical education and physical activity standards of the South Carolina Students Health and Fitness Act of 2005 in Title I elementary schools. The study was framed using selected components of the diffusion of innovations theory, which looked at characteristics of the law and their…

  3. Progress in Prevention: Report on the National Study of Local Education Agency Activities under the Safe and Drug Free Schools and Communities Act.

    ERIC Educational Resources Information Center

    Hantman, Irene; Crosse, Scott

    Although school districts are critical to the operation of the Safe and Drug-Free Schools and Communities Act (SDFSCA) Program, relatively little is known about how they plan, implement, and evaluate their SDFSCA-funded prevention activities. The U.S. Department of Education initiated this study to provide a more complete description of the ways…

  4. Integrated Application of Active Controls (IAAC) technology to an advanced subsonic transport project: Final ACT configuration evaluation. Final Report, October 1980-April 1981

    SciTech Connect

    Not Available

    1982-02-01

    The Final ACT Configuration Evaluation Task of the Integrated Application of Active Controls (IAAC) technology project within the energy efficient transport program is summarized. The Final ACT Configuration, through application of Active Controls Technology (ACT) in combination with increased wing span, exhibits significant performance improvements over the conventional baseline configuration. At the design range for these configurations, 3590 km, the block fuel used is 10% less for the Final ACT Configuration, with significant reductions in fuel usage at all operational ranges. Results of this improved fuel usage and additional system and airframe costs and the complexity required to achieve it were analyzed to determine its economic effects. For a 926 km mission, the incremental return on investment is nearly 25% at 1980 fuel prices. For longer range missions or increased fuel prices, the return is greater. The technical risks encountered in the Final ACT Configuration design and the research and development effort required to reduce these risks to levels acceptable for commercial airplane design are identified.

  5. Effective instruction for English learners.

    PubMed

    Calderón, Margarita; Slavin, Robert; Sánchez, Marta

    2011-01-01

    The fastest-growing student population in U.S. schools today is children of immigrants, half of whom do not speak English fluently and are thus labeled English learners. Although the federal government requires school districts to provide services to English learners, it offers states no policies to follow in identifying, assessing, placing, or instructing them. Margarita Calderón, Robert Slavin, and Marta Sánchez identify the elements of effective instruction and review a variety of successful program models. During 2007-08, more than 5.3 million English learners made up 10.6 percent of the nation's K-12 public school enrollment. Wide and persistent achievement disparities between these English learners and English-proficient students show clearly, say the authors, that schools must address the language, literacy, and academic needs of English learners more effectively. Researchers have fiercely debated the merits of bilingual and English-only reading instruction. In elementary schools, English learners commonly receive thirty minutes of English as a Second Language (ESL) instruction but attend general education classes for the rest of the day, usually with teachers who are unprepared to teach them. Though English learners have strikingly diverse levels of skills, in high school they are typically lumped together, with one teacher to address their widely varying needs. These in-school factors contribute to the achievement disparities. Based on the studies presented here, Calderón, Slavin, and Sánchez assert that the quality of instruction is what matters most in educating English learners. They highlight comprehensive reform models, as well as individual components of these models: school structures and leadership; language and literacy instruction; integration of language, literacy, and content instruction in secondary schools; cooperative learning; professional development; parent and family support teams; tutoring; and monitoring implementation and outcomes

  6. Interaction of African American Learners Online: An Adult Education Perspective

    ERIC Educational Resources Information Center

    Kang, Haijun; Yang, Yang

    2016-01-01

    This study examines how various life factors and personal attributes affect African American adult learners' use of the three types of learning interaction-learner-content, learner-instructor, and learner-learner. Multivariate multiple regression analyses were used. The aggregate effect of life factors on African American adult learners' use of…

  7. "Speech Act" Fra Teoria e Prassi Didattica. (The Speech Act between Theory and Pedagogical Practice).

    ERIC Educational Resources Information Center

    Minardi, Giovanni

    1982-01-01

    The author traces the development of speech act theory from Wittgenstein and Austin through Searle to Grice and shows how their work led to the notional functional approach to language teaching, which is based on the learner and his/her communicative needs. (CFM)

  8. Performance test results of noninvasive characterization of Resource Conservation and Recovery Act surrogate waste by prompt gamma neutron activation analysis

    SciTech Connect

    Gehrke, R.J.; Streier, G.G.

    1997-03-01

    During FY-96, a performance test was carried out with funding from the Mixed Waste Focus Area (MWFA) of the Department of Energy (DOE) to determine the noninvasive elemental assay capabilities of commercial companies for Resource Conservation and Recovery Act (RCRA) metals present in 8-gal drums containing surrogate waste. Commercial companies were required to be experienced in the use of prompt gamma neutron activation analysis (PGNAA) techniques and to have a prototype assay system with which to conduct the test assays. Potential participants were identified through responses to a call for proposals advertised in the Commerce Business Daily and through personal contacts. Six companies were originally identified. Two of these six were willing and able to participate in the performance test, as described in the test plan, with some subsidizing from the DOE MWFA. The tests were conducted with surrogate sludge waste because (1) a large volume of this type of waste awaits final disposition and (2) sludge tends to be somewhat homogeneous. The surrogate concentrations of the above RCRA metals ranged from {approximately} 300 ppm to {approximately} 20,000 ppm. The lower limit was chosen as an estimate of the expected sensitivity of detection required by noninvasive, pretreatment elemental assay systems to be of value for operational and compliance purposes and to still be achievable with state-of-the-art methods of analysis. The upper limit of {approximately} 20,000 ppm was chosen because it is the opinion of the author that assay above this concentration level is within current state-of-the-art methods for most RCRA constituents. This report is organized into three parts: Part 1, Test Plan to Evaluate the Technical Status of Noninvasive Elemental Assay Techniques for Hazardous Waste; Part 2, Participants` Results; and Part 3, Evaluation of and Comments on Participants` Results.

  9. Chlamydia screening for sexually active young women under the Affordable Care Act: new opportunities and lingering barriers.

    PubMed

    Loosier, Penny S; Malcarney, Mary-Beth; Slive, Lauren; Cramer, Ryan C; Burgess, Brittany; Hoover, Karen W; Romaguera, Raul

    2014-09-01

    The Affordable Care Act of 2010 (ACA) contains a provision requiring private insurers issuing or renewing plans on or after September 23, 2010, to provide, without cost sharing, preventive services recommended by US Preventive Services Task Force (grades A and B), among other recommending bodies. As a grade A recommendation, chlamydia screening for sexually active young women 24 years and younger and older women at risk for chlamydia falls under this requirement. This article examines the potential effect on chlamydia screening among this population across private and public health plans and identifies lingering barriers not addressed by this legislation. Examination of the impact on women with private insurance touches upon the distinction between coverage under grandfathered plans, where the requirement does not apply, and nongrandfathered plans, where the requirement does apply. Acquisition of private health insurance through health insurance Marketplaces is also discussed. For public health plans, coverage of preventive services without cost sharing differs for individuals enrolled in standard Medicaid, covered under the Medicaid expansion included in the ACA, or those enrolled under the Children's Health Insurance Program or who fall under Early, Periodic, Screening, Diagnosis and Treatment criteria. The discussion of lingering barriers not addressed by the ACA includes the uninsured, physician reimbursement, cost sharing, confidentiality, low rates of appropriate sexual history taking by providers, and disclosures of sensitive information. In addition, the role of safety net programs that provide health care to individuals regardless of ability to pay is examined in light of the expectation that they also remain a payer of last resort.

  10. Memory re-differentiation and reduced lymphocyte activation in chronic HCV-infected patients receiving direct-acting antivirals.

    PubMed

    Burchill, M A; Golden-Mason, L; Wind-Rotolo, M; Rosen, H R

    2015-12-01

    Recently, the treatment of HCV has advanced significantly due to the introduction of direct-acting antivirals (DAAs). Studies using interferon (IFN)-containing regimens failed to consistently show restoration of immunologic responses. Therefore, IFN-free DAA formulations provide a unique opportunity to dissect the immunologic effect of HCV cure. This study investigates the restoration of the immune compartment as a consequence of rapid viral clearance in patients successfully treated with DAAs and in the absence of IFN and ribavirin. Here, we evaluate the immunologic changes that occurred following DAA-mediated HCV cure. Peripheral blood from nineteen previously treatment-naïve patients with chronic HCV genotype 1a/1b who received an IFN and ribavirin-free regimen of daclatasvir, asunaprevir and BMS-791325 was evaluated. Immune reconstitution occurs in patients in whom HCV was successfully eradicated via DAA therapy. Restoration of the CD4(+) T-cell compartment in the peripheral blood and a re-differentiation of the T lymphocyte memory compartment resulted in a more effector memory cell population and a reduction in expression in the co-inhibitory molecule TIGIT in bulk T lymphocytes. Furthermore, we observed a partial reversal of the exhausted phenotype in HCV-specific CD8(+) T cells and a dampening of the activation state in peripheral NK cells. Collectively, our data provide the groundwork for dissecting the effect of DAA therapy on the immune system and identifying novel mechanisms by which chronic HCV infection exerts immunosuppressive effects on T cells through the recently described co-inhibitory molecule TIGIT.

  11. 20 CFR 652.209 - What are the requirements under the Act for providing reemployment services and other activities...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... FUNCTIONING OF STATE EMPLOYMENT SERVICES Wagner-Peyser Act Services in a One-Stop Delivery System Environment... part of the One-Stop delivery system, must provide reemployment services to UI claimants for whom...

  12. Comparing Adaptive Control of Thought-Rational (ACT-R) Baseline Activation Terms for Implementation in the Symbolic and Subsymbolic Robotic Intelligence Control System (SS-RICS)

    DTIC Science & Technology

    2014-04-01

    Comparing Adaptive Control of Thought–Rational (ACT-R) Baseline Activation Terms for Implementation in the Symbolic and Subsymbolic Robotic ...Baseline Activation Terms for Implementation in the Symbolic and Subsymbolic Robotic Intelligence Control System (SS-RICS) Craig T. Lennon...Implementation in the Symbolic and Subsymbolic Robotic Intelligence Control System (SS-RICS) 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c

  13. Study Partners Recommendation for xMOOCs Learners

    PubMed Central

    Xu, Bin; Yang, Dan

    2015-01-01

    Massive open online courses (MOOCs) provide an opportunity for people to access free courses offered by top universities in the world and therefore attracted great attention and engagement from college teachers and students. However, with contrast to large scale enrollment, the completion rate of these courses is really low. One of the reasons for students to quit learning process is problems which they face that could not be solved by discussing them with classmates. In order to keep them staying in the course, thereby further improving the completion rate, we address the task of study partner recommendation for students based on both content information and social network information. By analyzing the content of messages posted by learners in course discussion forum, we investigated the learners' behavior features to classify the learners into three groups. Then we proposed a topic model to measure learners' course knowledge awareness. Finally, a social network was constructed based on their activities in the course forum, and the relationship in the network was then employed to recommend study partners for target learner combined with their behavior features and course knowledge awareness. The experiment results show that our method achieves better performance than recommending method only based on content information. PMID:25663836

  14. Focus on Form, Learner Uptake and Subsequent Lexical Gains in Learners' Oral Production

    ERIC Educational Resources Information Center

    Alcon-Soler, Eva

    2009-01-01

    This descriptive study reports findings on the relationship between focus on form, learner uptake and subsequent lexical gains in learners' oral production. The data for the study consisted in 17 45-minute audio-recorded teacher-led conversations, 204 learners' diaries (17 sessions x 12 learners) reporting what they had learned after each…

  15. Teacher Perceptions of Learner-Learner Engagement at a Cyber High School

    ERIC Educational Resources Information Center

    Borup, Jered

    2016-01-01

    Distance education has historically contained little or no learner-learner interactions. Currently the Internet allows for unprecedented levels of learner-learner interaction and has the potential to transform how students learn online. However, many courses offered online focus more on flexibility and independence than on interaction and…

  16. Affective Dimensions of the Japanese Foreign Language Learner: Implications for Psychological Learner Development in Japan

    ERIC Educational Resources Information Center

    Fukuchi, Naoko Tani; Sakamoto, Robin

    2005-01-01

    As learner-centred approaches are gaining popularity in many language classrooms, the affective dimensions of learners and the interaction effects of learners and teachers have become an important theme for research and assessment. This paper explores how Japanese learners of English as a foreign language evolve in two geographically distinct…

  17. Explicit and Implicit Feedback, Modified Output, and SLA: Does Explicit and Implicit Feedback Promote Learning and Learner-Learner Interactions?

    ERIC Educational Resources Information Center

    Adams, Rebecca; Nuevo, Ana Maria; Egi, Takako

    2011-01-01

    Research on interactional feedback has typically focused on feedback learners receive from native speakers (i.e., NS-learner contexts). However, for many second language (L2) learners, the majority of their opportunities to engage in interaction occur with other learners (i.e., learner-learner contexts). The literature has suggested that feedback…

  18. Collaborative Revision in L2 Writing: Learners' Reflections

    ERIC Educational Resources Information Center

    Memari Hanjani, Alireza

    2016-01-01

    L2 learning literature has reflected on the problems surrounding the application of teacher written feedback and peer feedback in EFL contexts. To address the disadvantages of these feedback forms, this exploratory case study examined EFL learners' reactions to a collaborative revision activity. Interview data were collected from eight native…

  19. Administrative Roles in Helping Faculty Adapt to Adult Learners.

    ERIC Educational Resources Information Center

    Miller, Keith A.

    Since the number of adult students engaging in higher education activities is growing rapidly and is expected to continue to climb, this paper is intended to help administrators develop a perspective from which to view adult learners on college campuses and craft programs to help faculty work more effectively with adult students. The first section…

  20. Motivation and Interlanguage Pragmatics in Iranian English Language Learners

    ERIC Educational Resources Information Center

    Khorshidi, Hassan Rasouli; Nimchahi, Abdolreza Bagherzadeh

    2013-01-01

    It is generally believed that interlanguage pragmatics and motivation play important roles in learning. Motivation is important because it determines the extent of the learner's active involvement and attitude toward learning. The major purpose of this study was to investigate the impact of integrative and instrumental motivation on the…

  1. The Campus Leadership as a Community of Learners.

    ERIC Educational Resources Information Center

    Albers, Randy

    Students are increasingly expected to be able to think critically, solve complex problems, and communicate clearly. Educators are expected to facilitate that learning in a variety of situations for an increasingly individualized student population. Therefore, educators who attempt to change their practices must become active learners. A school…

  2. Boosting Language Skills of English Learners through Dramatization and Movement

    ERIC Educational Resources Information Center

    Greenfader, Christa Mulker; Brouillette, Liane

    2013-01-01

    This article presents an arts integration program that uses drama and dance to promote foundational literacy skills, with an emphasis on the oral development of English Language Learners (ELLs). Previous research indicates that arts activities afford a beneficial opportunity for young students to practice language skills, but many teachers have…

  3. A Study of Pharmacists' Behavior as Lifelong Learners.

    ERIC Educational Resources Information Center

    Hanson, Alan L.; DeMuth, James E.

    1992-01-01

    A national survey of 355 licensed pharmacists investigated their perceptions of themselves as lifelong learners, participation in various professional and leisure activities, attitudes predicting lifelong learning behavior, and respondent characteristics. The two analytical models used arrived at different demographic and other variables…

  4. Are Online Learners Frustrated with Collaborative Learning Experiences?

    ERIC Educational Resources Information Center

    Capdeferro, Neus; Romero, Margarida

    2012-01-01

    Online education increasingly puts emphasis on collaborative learning methods. Despite the pedagogical advantages of collaborative learning, online learners can perceive collaborative learning activities as frustrating experiences. The purpose of this study was to characterize the feelings of frustration as a negative emotion among online learners…

  5. Learner Experiences in Web-Based Language Learning

    ERIC Educational Resources Information Center

    Son, Jeong-Bae

    2007-01-01

    The World Wide Web offers a global database of authentic materials that can enhance language learning and teaching. This study examines the use of the web for language learning through a study of English as a second language (ESL) learners' experiences in web-based language learning (WBLL) activities in an English language intensive course for…

  6. Language Development for English Language Learners. Facilitator's Guide

    ERIC Educational Resources Information Center

    Rivera, Mabel O.; Moughamian, Ani; Francis, David J.

    2009-01-01

    This Facilitator's Guide has been prepared for presenters of the "Language Development for English Language Learners" professional development module. It accompanies the 67-slide PowerPoint presentation with speaker's notes and contains materials to help prepare for a professional development session, including activity instructions, handouts,…

  7. Adults as Learners. Increasing Participation and Facilitating Learning.

    ERIC Educational Resources Information Center

    Cross, K. Patricia

    The literature on adult learners is reviewed, and two models of adult learning are developed. Demographic, social, and technological trends that stimulate the increasing demand for learning opportunities are examined, and the views of those who see dangers in new pressures on adults to participate in organized learning activities are considered.…

  8. Adapting a Social Studies Lesson to Include English Language Learners

    ERIC Educational Resources Information Center

    Pappamihiel, N. Eleni; Lake, Vickie E.; Rice, Diana C.

    2005-01-01

    If one were to search for classroom strategies for English Language Learners (ELLs), it would not take much time to find many different types of activities that are all useful with ELLs. Additionally, if one were to search for social studies strategies to use with native English speakers, he or she would have little difficulty in finding a variety…

  9. Using Young Adult Literature with Adolescent Learners of English.

    ERIC Educational Resources Information Center

    Watts, Elizabeth L.

    1999-01-01

    Discusses (1) a rationale for using young adult literature with adolescent English-as-a-Second-Language learners; (2) an approach to teaching the novel "Make Lemonade" by Virginia Euwer Wolff; (3) activities in which students engaged and samples of their work; and (4) implications for teachers who explore young adult literature with…

  10. The diagnosis of LD in English learners: is it nondiscriminatory?

    PubMed

    Figueroa, Richard A; Newsome, Patricia

    2006-01-01

    This study examined the operationalization of one of the key reforms initiated by the Education for All Handicapped Children Act of 1975 (U.S. Congress, 1975) and continued through the 2004 reauthorization of the Individuals with Disabilities Education Act (U.S. Congress, 2004)--namely, nondiscriminatory assessment. The original and current specifications in federal law require that tests be selected and administered so as not to be racially, culturally, or sexually discriminatory. The specific dimensions studied here pertain to the nondiscriminatory diagnosis of learning disabilities (LD) in English learners. A checklist of legal and professional guidelines for making assessments of English learners was used to evaluate 19 psychological reports made on English learners as part of the assessment process for special education eligibility in a small, urban elementary school district in California. The results of this study present a fairly compelling profile of how the writers of psychological reports--school psychologists--do not use extant legal or professional guidelines for making nondiscriminatory assessments of bilingual children.

  11. Learner Control in Computer Assisted Learning.

    ERIC Educational Resources Information Center

    Holmes, N.; And Others

    1985-01-01

    An investigation of how secondary students coped when taught binary arithmetic through a computer assisted instruction program used four treatment groups: learner control, learner control with advice; random program control, and adaptive program control. The random group performed less well, but no differences were found between learner and…

  12. Technology Applications for the Exceptional Learner.

    ERIC Educational Resources Information Center

    Burke, Janet

    This paper is a series of lesson plans designed to assist teachers with the instruction of the exceptional learner. The focus is on identifying what the exceptional learner needs, and provides specific lesson plans that met those needs. Exceptional learners experience difficulty with spelling, organization, and metacognition. Detailed directions…

  13. Becoming a Strategic Language Learner in CALL

    ERIC Educational Resources Information Center

    Cohen, Andrew D.

    2007-01-01

    This article outlines what it means to be a strategic language learner in the context of Computer-Assisted Language Learning (CALL). It looks at the possible roles for language learner strategies at their crucial intersection with language learning technology. We will first consider what language learner strategies have been represented in…

  14. Factors Influencing Chinese Language Learners' Strategy Use

    ERIC Educational Resources Information Center

    Sung, Ko-Yin

    2011-01-01

    This survey study, which involved 134 language learners enrolled in first-year Chinese as a foreign language classrooms in the US universities, intended to address the research question, "Do learners' strategy use differ based on the following learner differences: (1) gender; (2) home language/culture; and (3) number of other foreign languages…

  15. An Open Learner Model for Trainee Pilots

    ERIC Educational Resources Information Center

    Gakhal, Inderdip; Bull, Susan

    2008-01-01

    This paper investigates the potential for simple open learner models for highly motivated, independent learners, using the example of trainee pilots. In particular we consider whether such users access their learner model to help them identify their current knowledge level, areas of difficulty and specific misconceptions, to help them plan their…

  16. The Adult Learner: Some Things We Know

    ERIC Educational Resources Information Center

    Fogarty, Robin J.; Pete, Brian M.

    2007-01-01

    This book addresses the "warrior" who rises to the challenge of teaching the adult learner. The discussion is designed as a catalyst for dialogue about the adult learner and to uncover the complexities of teaching this rare and riveting species. This book is organized around three interlocking themes: some things we know about the adult learner;…

  17. Educating Young Children: Active Learning Practices for Preschool and Child Care Programs [and] A Study Guide to Educating Young Children: Exercises for Adult Learners. Second Edition.

    ERIC Educational Resources Information Center

    Hohmann, Mary; Weikart, David P.

    High/Scope preschool curriculum is a model for developing high-quality early childhood programs that encourage and support children's initiatives and active learning experiences. This revised manual for early childhood practitioners and students presents essential strategies adults can use to make active learning a reality in their programs. The…

  18. Integrated Application of Active Controls (IAAC) technology to an advanced subsonic transport project: Current and advanced act control system definition study, volume 1

    NASA Technical Reports Server (NTRS)

    Hanks, G. W.; Shomber, H. A.; Dethman, H. A.; Gratzer, L. B.; Maeshiro, A.; Gangsaas, D.; Blight, J. D.; Buchan, S. M.; Crumb, C. B.; Dorwart, R. J.

    1981-01-01

    An active controls technology (ACT) system architecture was selected based on current technology system elements and optimal control theory was evaluated for use in analyzing and synthesizing ACT multiple control laws. The system selected employs three redundant computers to implement all of the ACT functions, four redundant smaller computers to implement the crucial pitch-augmented stability function, and a separate maintenance and display computer. The reliability objective of probability of crucial function failure of less than 1 x 10 to the -9th power per flight of 1 hr can be met with current technology system components, if the software is assumed fault free and coverage approaching 1.0 can be provided. The optimal control theory approach to ACT control law synthesis yielded comparable control law performance much more systematically and directly than the classical s-domain approach. The ACT control law performance, although somewhat degraded by the inclusion of representative nonlinearities, remained quite effective. Certain high-frequency gust-load alleviation functions may require increased surface rate capability.

  19. More than a "Basic Skill": Breaking down the Complexities of Summarizing for ABE/ESL Learners

    ERIC Educational Resources Information Center

    Ouellette-Schramm, Jennifer

    2015-01-01

    This article describes the complex cognitive and linguistic challenges of summarizing expository text at vocabulary, syntactic, and rhetorical levels. It then outlines activities to help ABE/ESL learners develop corresponding skills.

  20. 10 CFR 50.13 - Attacks and destructive acts by enemies of the United States; and defense activities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Attacks and destructive acts by enemies of the United... LICENSING OF PRODUCTION AND UTILIZATION FACILITIES Requirement of License, Exceptions § 50.13 Attacks and... required to provide for design features or other measures for the specific purpose of protection...

  1. 10 CFR 50.13 - Attacks and destructive acts by enemies of the United States; and defense activities.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Attacks and destructive acts by enemies of the United... LICENSING OF PRODUCTION AND UTILIZATION FACILITIES Requirement of License, Exceptions § 50.13 Attacks and... required to provide for design features or other measures for the specific purpose of protection...

  2. 50 CFR 80.50 - What activities are eligible for funding under the Pittman-Robertson Wildlife Restoration Act?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... under the Pittman-Robertson Wildlife Restoration Act? 80.50 Section 80.50 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR (CONTINUED) FINANCIAL ASSISTANCE-WILDLIFE...-oriented recreation. (7) Operate or maintain: (i) Projects that the State fish and wildlife...

  3. 77 FR 59204 - Agency Information Collection Activities: Affidavit of Support Under Section 213A of the Act...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-26

    ... Section 213A of the Act; Form I-864W, Intending Immigrant's Affidavit of Support Exemption; Revision of a..., Intending Immigrant's Affidavit of Support Exemption; USCIS. (4) Affected public who will be asked or... by family-based and certain employment-based immigrants to have the petitioning relative execute...

  4. Individual Learner Differences in SLA

    ERIC Educational Resources Information Center

    Arabski, Janusz; Wojtaszek, Adam

    2011-01-01

    "Individual Learner Differences in SLA" addresses the apparently insoluble conflict between the unquestionably individual character of the process of second language acquisition/foreign language learning and the institutionalised, often inflexible character of formal instruction in which it takes place. How, then, is success in SLA so prevalent?

  5. Facilitating Creativity in Adult Learners

    ERIC Educational Resources Information Center

    Tsai, Kuan Chen

    2013-01-01

    Creativity in education research has received increasing attention, although the major focus of this research has been on children. Despite pleas by several adult educators for promoting creativity, very few studies have focused on adult learners, leaving to it to be explored what approaches are useful for adult educators to facilitate creativity…

  6. Motivational Profiles of Adult Learners

    ERIC Educational Resources Information Center

    Rothes, Ana; Lemos, Marina S.; Gonçalves, Teresa

    2017-01-01

    This study investigated profiles of autonomous and controlled motivation and their effects in a sample of 188 adult learners from two Portuguese urban areas. Using a person-centered approach, results of cluster analysis and multivariate analysis of covariance revealed four motivational groups with different effects in self-efficacy, engagement,…

  7. Teacher Investment in Learner Identity

    ERIC Educational Resources Information Center

    Reeves, Jenelle

    2009-01-01

    From a sociocultural perspective, teacher identity is constructed in relation to others, including other teachers and students. Drawing on positioning theory and the concept of investment, this study analyzed the case of a secondary English teacher who negotiated his teacher identity in relation to English language learners (ELLs). Findings…

  8. Grading Exceptional and Struggling Learners

    ERIC Educational Resources Information Center

    Jung, Lee Ann; Guskey, Thomas R.

    2011-01-01

    How can you ensure that you are grading your exceptional students fairly? Teachers receive very little guidance for grading students with disabilities, English learners, and those receiving services through a response-to-intervention (RTI) process. This practitioner-friendly book provides teachers and administrators with an effective framework for…

  9. Developing Collections to Empower Learners

    ERIC Educational Resources Information Center

    Kimmel, Sue C.

    2014-01-01

    "Developing Collections to Empower Learners" examines collection development in the context of today's shifts toward digital resources while emphasizing the foundational beliefs of the school library profession. Writer Sue Kimmel includes practical advice about needs assessment, planning, selection, acquisitions, evaluation, and…

  10. Are Deaf Students Visual Learners?

    ERIC Educational Resources Information Center

    Marschark, Marc; Morrison, Carolyn; Lukomski, Jennifer; Borgna, Georgianna; Convertino, Carol

    2013-01-01

    It is frequently assumed that by virtue of their hearing losses, deaf students are visual learners. Deaf individuals have some visual-spatial advantages relative to hearing individuals, but most have been linked to use of sign language rather than auditory deprivation. How such cognitive differences might affect academic performance has been…

  11. Shifting Power to the Learner

    ERIC Educational Resources Information Center

    Wolf, Alison

    2010-01-01

    Decades of reform have resulted in a system of further education that treats adults like children, with limited control over the qualifications they choose to pursue. This needs to change. Money must follow learners, not government contracts, and so create a genuinely demand-led system. The author proposes new financial and regulatory structures…

  12. English Language Learner Engineering Collaborative

    ERIC Educational Resources Information Center

    Pendergraft, Katy; Daugherty, Michael K.; Rossetti, Charles

    2009-01-01

    In an effort to develop an engineering design project that would deliver the necessary content and reach out to the English Language Learner (ELL) community, faculty in the Engineering Academy at Springdale High School in Springdale, Arkansas instituted the ELL Engineering Collaborative. The ELL Engineering Collaborative has four primary goals…

  13. Teaching Reading to Struggling Learners

    ERIC Educational Resources Information Center

    Minskoff, Esther

    2005-01-01

    Identifying the best way to help students who struggle with reading--whether they have learning disabilities, are English language learners, or just need extra support--is a challenge for any teacher. Schools can make that task easier with this indispensable resource, a complete guide to addressing each student's specific instructional needs and…

  14. Reading and the Special Learner.

    ERIC Educational Resources Information Center

    Hedley, Carolyn N., Ed.; Hicks, John S., Ed.

    Compiled from papers presented at the annual Reading/Special Education Institute at Fordham University, this collection of essays addresses reading problems of special education students. The book is divided into three sections. The first section covers reading assessment and reading intervention; section 2 addresses the specific learner and the…

  15. Learner-Centered Online Instruction

    ERIC Educational Resources Information Center

    McCombs, Barbara

    2015-01-01

    This chapter offers a theoretical rationale and an explanation of evidence for using research-validated, learner-centered principles and practices in online course development, highlighting the evidence-based practices that have been used successfully to develop online courses that engage and retain students.

  16. English Language Learners: Annotated Bibliography

    ERIC Educational Resources Information Center

    Hector-Mason, Anestine; Bardack, Sarah

    2010-01-01

    This annotated bibliography represents a first step toward compiling a comprehensive overview of current research on issues related to English language learners (ELLs). It is intended to be a resource for researchers, policymakers, administrators, and educators who are engaged in efforts to bridge the divide between research, policy, and practice…

  17. English Learners Program Guide. Revised

    ERIC Educational Resources Information Center

    Oregon Department of Education, 2013

    2013-01-01

    This guide is designed as a reference for District and School personnel working with English learners (ELs). The content of the guide represents a compilation of information, examples, and resources. This guide is a living document and subject to frequent updates. It is recommended to review the document online rather than printing a hard copy.

  18. Distance Learners: Welcome to Campus!

    ERIC Educational Resources Information Center

    Schwitzer, Alan M.; Duggan, Mary H.

    2005-01-01

    Old Dominion University's distance learning program, called TELETECHNET, brings the main-campus college experience to geographically distant learners at sites across Virginia and as far away as the state of Washington, as well as to military personnel on Navy bases, carriers, and submarines. In an interesting turnabout, the Summer Institute for…

  19. Rich Environments for Adult Learners

    ERIC Educational Resources Information Center

    Bentham, Renee

    2008-01-01

    Unaware of the messages a bare adult learning environment sends and its effect on adult learners, a trainer attends an intensive Reggio Emilia course and learns that the physical environment is the "third teacher"--for adults as well as for children. Using principles of Reggio, she offers suggestions for enhancing adult learning spaces and…

  20. Learner Differences in Hint Processing

    ERIC Educational Resources Information Center

    Goldin, Ilya M.; Koedinger, Kenneth R.; Aleven, Vincent

    2012-01-01

    Although ITSs are supposed to adapt to differences among learners, so far, little attention has been paid to how they might adapt to differences in how students learn from help. When students study with an Intelligent Tutoring System, they may receive multiple types of help, but may not comprehend and make use of this help in the same way. To…

  1. Faculty Development: Assessing Learner Achievement.

    ERIC Educational Resources Information Center

    Frey, Barbara A.; Overfield, Karen

    This study addressed the challenges of developing a faculty professional development workshop on assessment, measurement, and evaluation of achievement in adult learners. The setting for the workshop was a system of postsecondary career colleges throughout the United States. The curriculum development model of D. Kirkpatrick (1994) was used as a…

  2. THE SIGNIFICANCE OF LEARNER'S ERRORS.

    ERIC Educational Resources Information Center

    CORDER, S.P.

    ERRORS (NOT MISTAKES) MADE IN BOTH SECOND LANGUAGE LEARNING AND CHILD LANGUAGE ACQUISITION PROVIDE EVIDENCE THAT A LEARNER USES A DEFINITE SYSTEM OF LANGUAGE AT EVERY POINT IN HIS DEVELOPMENT. THIS SYSTEM, OR "BUILT-IN SYLLABUS," MAY YIELD A MORE EFFICIENT SEQUENCE THAN THE INSTRUCTOR-GENERATED SEQUENCE BECAUSE IT IS MORE MEANINGFUL TO THE…

  3. Learners in Action, Summer 2005

    ERIC Educational Resources Information Center

    Movement for Canadian Literacy, 2005

    2005-01-01

    This Summer 2005 issue of "Learners in Action" contains the following articles: (1) Bridging Barriers to Learning (Glenn Kissman); (2) Education Really Is a Family Affair; (3) Sabrina's Story; (4) SARAW Helps Students Find Their Voice; (5) Literacy Changes Lives; and (6) Seeing STARs in Alberta.

  4. Language Learners' Perceptions of Accent

    ERIC Educational Resources Information Center

    Scales, Julie; Wennerstrom, Ann; Richard, Dara; Wu, Su Hui

    2006-01-01

    This study analyzed the accent perceptions of a group of 37 English language learners and 10 American undergraduate students. Each subject listened to a one-minute passage read by four speakers with different accents of English: General American, British English, Chinese English, and Mexican English. Participants then attempted to identify the…

  5. for Teachers of English Learners

    ERIC Educational Resources Information Center

    Molle, Daniella

    2013-01-01

    For more than a decade, the professional development literature has shown that most teachers are not adequately prepared to teach English learners (ELs)--that holds true for both specialist and mainstream teachers (see, for example, August & Hakuta, 1997; Beykont, 2002). Research that focuses on professional development for teachers of ELs,…

  6. Learners' Use of Learning Objects

    ERIC Educational Resources Information Center

    Ally, Mohamed; Cleveland-Innes, Martha; Boskic, Natasha; Larwill, Sandra

    2006-01-01

    This article reports findings from a study exploring the generativity (Gibbons, Nelson, & Richards, 2000; Parrish, 2004) and discoverability (Friesen, 2001) of learning objects in the hands of the learner. Through the convergence of two separate pilot projects--the Canadian EduSource initiative through Athabasca University, and the…

  7. Adult Learners in the Academy

    ERIC Educational Resources Information Center

    Bash, Lee

    1999-01-01

    Adult learners comprise almost 50 percent of all students enrolled in higher Education. Some argue they are pioneering change in today's higher educational landscape. This book is designed to assist faculty members and administrators who want to understand how the impact of adult learning programs has and is helping to transform the academy and…

  8. Can You Keep Learners Online?

    ERIC Educational Resources Information Center

    Zielinski, Dave

    2000-01-01

    Reasons people do not complete online training courses include (1) no incentives, (2) lack of connectedness, (3) learner preference for instructor-led courses, (4) poor course design, (5) "some is enough," and (6) lack of perks. Course delivery must consider three elements: the technology, course design, and the learning environment. (JOW)

  9. The Effects of Direct and Indirect Speech Acts on Native English and ESL Speakers' Perception of Teacher Written Feedback

    ERIC Educational Resources Information Center

    Baker, Wendy; Hansen Bricker, Rachel

    2010-01-01

    This study explores how second language (L2) learners perceive indirect (hedging or indirect speech acts) and direct written teacher feedback. Though research suggests that indirect speech acts may be more difficult to interpret than direct speech acts ([Champagne, 2001] and [Holtgraves, 1999]), using indirect speech acts is often encouraged in…

  10. The Effects of an Enhanced Quality Physical Education Programme on the Physical Activity Levels of Grade 7 Learners in Potchefstroom, South Africa

    ERIC Educational Resources Information Center

    Tian, Haili; du Toit, Dorita; Toriola, Abel L.

    2017-01-01

    Background: The absence of Physical Education (PE) from the South African school curriculum before its reintroduction in recent years contributed to health concerns regarding the low physical activity (PA) levels of children and adolescents in South Africa. Purpose: This study evaluated the effects of a once-a-week enhanced quality PE programme on…

  11. Transcriptional activation of the herpes simplex virus type 1 UL38 promoter conferred by the cis-acting downstream activation sequence is mediated by a cellular transcription factor.

    PubMed

    Guzowski, J F; Singh, J; Wagner, E K

    1994-12-01

    The herpes simplex virus (HSV) type 1 strict late (gamma) UL38 promoter contains three cis-acting transcriptional elements: a TATA box, a specific initiator element, and the downstream activation sequence (DAS). DAS is located between positions +20 and +33 within the 5' untranslated leader region and strongly influences transcript levels during productive infection. In this communication, we further characterize DAS and investigate its mechanism of action. DAS function has a strict spacing requirement, and DAS contains an essential 6-bp core element. A similarly positioned element from the gamma gC gene (UL44) has partial DAS function within the UL38 promoter context, and the promoter controlling expression of the gamma US11 transcript contains an identically located element with functional and sequence similarity to UL38 DAS. These data suggest that downstream elements are a common feature of many HSV gamma promoters. Results with recombinant viruses containing modifications of the TATA box or initiator element of the UL38 promoter suggest that DAS functions to increase transcription initiation and not the efficiency of transcription elongation. In vitro transcription assays using uninfected HeLa nuclear extracts show that, as in productive infection with recombinant viruses, the deletion of DAS from the UL38 promoter dramatically decreases RNA expression. Finally, electrophoretic mobility shift assays and UV cross-linking experiments show that DAS DNA forms a specific, stable complex with a cellular protein (the DAS-binding factor) of approximately 35 kDa. These data strongly suggest that the interaction of cellular DAS-binding factor with DAS is required for efficient expression of UL38 and other HSV late genes.

  12. Beyond Classroom Discourse: Learning as Participation in Native Speaker-Learner and Learner-Learner Interactions

    ERIC Educational Resources Information Center

    Hoshi, Saori

    2015-01-01

    Consistent with the notion of learning as changing participation (Lave & Wenger, 1991; Rogoff, 1998; Sfard, 1998; Young & Miller, 2004), the present qualitative study investigated how social interaction between learners of Japanese as a foreign language and native speaker classroom guests contributed to the students' use of second language…

  13. Plurilingual Learners' Beliefs and Practices toward Native and Nonnative Language Mediation during Learner-Learner Interaction

    ERIC Educational Resources Information Center

    Payant, Caroline

    2015-01-01

    Due to the growing number of plurilingual learners in the world today (Hammarberg, 2010), the present multiple case study examines four plurilingual participants' beliefs toward first language (L1) and second language (L2) mediation in the acquisition of French as a third language (L3). During a 16-week classroom-based study in a French university…

  14. The Effects of Instruction on Learners' Production of Appropriate and Accurate Suggestions

    ERIC Educational Resources Information Center

    Martinez-Flor, Alicia; Fukuya, Yoshinori J.

    2005-01-01

    Only a few empirical studies have explored Focus on Form in the pragmatic realm. By operationalising this theoretical construct for an implicit condition, this study examined the effects of two types of pragmatic instruction (explicit and implicit) on learning head acts and downgraders in suggestions. Eighty-one Spanish learners of English took…

  15. Voices from the Field: Making State Assessment Decisions for English Language Learners with Disabilities

    ERIC Educational Resources Information Center

    Liu, Kristin K.; Goldstone, Linda; Thurlow, Martha L.; Ward, Jenna; Hatten, James; Christensen, Laurene L.

    2013-01-01

    English language learners (ELLs) with disabilities are an increasing presence in schools in the United States. Title I and Title III of the Elementary and Secondary Education Act require that these students meet the same academic grade-level standards and participate in content assessments as their fluent-English speaking peers without…

  16. Teaching English Language Learners in Mainstream Science Classrooms: Teacher Practice and Educational Opportunity

    ERIC Educational Resources Information Center

    Schroeder, Carlotta Dorothy

    2011-01-01

    Equal educational opportunity for English language learners (ELLs) has been a goal of the public educational system in the United States. Language policy reforms have increased accountability in order for schools to improve student achievement and measure the progress of ELLs. The No Child Left Behind Act (NCLB) requires assessment and…

  17. Rater Behaviour When Judging Language Learners' Pragmatic Appropriateness in Extended Discourse

    ERIC Educational Resources Information Center

    Sydorenko, Tetyana; Maynard, Carson; Guntly, Erin

    2014-01-01

    The criteria by which raters judge pragmatic appropriateness of language learners' speech acts are underexamined, especially when raters evaluate extended discourse. To shed more light on this process, the present study investigated what factors are salient to raters when scoring pragmatic appropriateness of extended request sequences, and which…

  18. Equitable Access for Secondary English Learner Students: Course Taking as Evidence of EL Program Effectiveness

    ERIC Educational Resources Information Center

    Callahan, Rebecca M.; Shifrer, Dara

    2016-01-01

    Purpose: English learner (EL) education policy has long directed schools to address EL students' linguistic "and" academic development without furthering inequity or segregation. The recent Every Student Succeeds Act reauthorization expresses a renewed focus on evidence of equity, effectiveness, and opportunity to learn. We propose that…

  19. ESSA and English Language Learners. Policy Update. Vol. 23, No. 21

    ERIC Educational Resources Information Center

    Parsi, Ace

    2016-01-01

    Representing an estimated 4.4 million students in the United States, English language learners (ELLs) are the fastest growing segment of the public school population and yet are twice as likely to drop out of high school and significantly less likely to attend and complete postsecondary education. The Every Student Succeeds Act (ESSA) includes…

  20. "No Child" Effect on English-Learners Mulled: Teachers Welcome Attention, Fault Focus on Test Scores

    ERIC Educational Resources Information Center

    Zehr, Mary Ann

    2006-01-01

    Educators who specialize in teaching English-language learners agree that the 4-year-old No Child Left Behind Act has brought unprecedented attention to those students by requiring schools to isolate test-score data for them. They disagree, though, on whether changes in instruction spurred by the law have been positive or negative overall. Such…

  1. State Education Policy Formation: The Case of Arizona's English Language Learner Legislation

    ERIC Educational Resources Information Center

    Lawton, Stephen B.

    2012-01-01

    This historical case study focuses on policy making at the state level by analyzing the development of a new policy for English language learners (ELLs) in Arizona. "New institutionalism" is used as a framework, with political culture and educational regimes acting as environmental factors affecting state policy choices. Key events…

  2. Programs for English Language Learners: Resource Materials for Planning and Self-Assessments.

    ERIC Educational Resources Information Center

    Office for Civil Rights (ED), Washington, DC.

    These resource materials were developed in response to requests from school districts for a reference tool to assist them through the process of developing a comprehensive English language learners (ELL) program. The districts desired a program that would be in compliance with Title VI of the Civil Rights Act of 1964. Title VI was passed in the…

  3. Using Animated Agents in Learner-Controlled Training: The Effects of Design Control

    ERIC Educational Resources Information Center

    Behrend, Tara S.; Thompson, Lori Foster

    2012-01-01

    Animated agents have the potential to increase engagement and learning during online training by acting as personalized tutors. However, little is known about the conditions that make these agents most effective. In this study, 183 e-learners completed a Microsoft Excel training course. Approximately half were assigned an agent with predetermined…

  4. Test Accommodations for English Language Learners Using the Student Language Assessment Plan

    ERIC Educational Resources Information Center

    Brantley, Sherri G.

    2014-01-01

    Public schools are attempting to work with a growing number of immigrant English language learners (ELLs) in the U.S. education system at a time when the No Child Left Behind (NCLB) Act has mandated that ELLs achieve proficiency on assessments even if they have not acquired sufficient language proficiency. The purpose of this qualitative case…

  5. Assessment of English Language Learners in the Era of New Academic Content Standards

    ERIC Educational Resources Information Center

    Bailey, Alison L.; Carroll, Patricia E.

    2015-01-01

    The purpose of this chapter is twofold: (1) to provide a detailed review of current language assessment policies and practices with English language learner (ELL) students under the federal requirements of the No Child Left Behind Act (NCLB; 2001) and relevant research in order to evaluate their technical quality and validity, and (2) to examine…

  6. Descriptive Study of State Assessment Policies for Accommodating English Language Learners

    ERIC Educational Resources Information Center

    Willner, Lynn Shafer; Rivera, Charlene; Acosta, Barbara D.

    2008-01-01

    In 2006, the Government Accountability Office (GAO) conducted a study of the U.S. Department of Education's (ED)'s efforts to support states in meeting the No Child Left Behind Act (NCLB) (Ashby, 2006). The study found the requirement to include all students, including English language learners (ELLs) in standards and assessment systems, a…

  7. Using Critical Literacy to Engage Learners: What New Teachers Can Do

    ERIC Educational Resources Information Center

    Shanklin, Nancy

    2009-01-01

    Shanklin knows that as school populations become more culturally and linguistically diverse, perspectives such as critical literacy become of interest to students themselves and act as keys to their engagement. Critical literacy marks an exciting shift in thinking toward English/language arts, global education, English language learners, and ways…

  8. Integrated Application of Active Controls (IAAC) technology to an advanced subsonic transport project: Test act system description

    NASA Technical Reports Server (NTRS)

    1983-01-01

    The engineering and fabrication of the test ACT system, produced in the third program element of the IAAC Project is documented. The system incorporates pitch-augmented stability and wing-load alleviation, plus full authority fly-by-wire control of the elevators. The pitch-augmented stability is designed to have reliability sufficient to allow flight with neutral or negative inherent longitudinal stability.

  9. Results of screening activities in salt states prior to the enactment of the Nationall Waste Policy Act

    SciTech Connect

    Carbiener, W.A.

    1983-01-01

    The identification of potential sites for a nuclear waste repository through screening procedures in the salt states is a well-established, deliberate process. This screening process has made it possible to carry out detailed studies of many of the most promising potential sites, and general studies of all the sites, in anticipation of the siting guidelines specified in the Nuclear Waste Policy Act. The screening work completed prior to the passage of the Act allowed the Secretary of Energy to identify seven salt sites as potentially acceptable under the provisions of Section 116(a) of the Act. These sites were formally identified by letters from Secretary Hodel to the states of Texas, Utah, Mississippi, and Louisiana on February 2, 1983. The potentially acceptable salt sites were in Deaf Smith and Swisher Counties in Texas; Davis and Lavender Canyons in the Gibson Dome location in Utah; Richton and Cypress Creek Domes in Mississippi; and Vacherie Dome in Louisiana. Further screening will include comparison of each potentially acceptable site against disqualification factors and selection of a preferred site in each of the three geohydrologic settings from those remaining, in accordance with the siting guidelines. These steps will be documented in statutory Environmental Assessments prepared for each site to be nominated for detailed characterization. 9 references.

  10. Integrated Application of Active Controls (IAAC) technology to an advanced subsonic transport project: Current and advanced act control system definition study

    NASA Technical Reports Server (NTRS)

    1982-01-01

    The Current and Advanced Technology ACT control system definition tasks of the Integrated Application of Active Controls (IAAC) Technology project within the Energy Efficient Transport Program are summarized. The systems mechanize six active control functions: (1) pitch augmented stability; (2) angle of attack limiting; (3) lateral/directional augmented stability; (4) gust load alleviation; (5) maneuver load control; and (6) flutter mode control. The redundant digital control systems meet all function requirements with required reliability and declining weight and cost as advanced technology is introduced.

  11. The Role of Private Speech in Cognitive Regulation of Learners: The Case of English as a Foreign Language Education

    ERIC Educational Resources Information Center

    Sarab, Mohamad Reza Anani; Gordani, Yahya

    2015-01-01

    Investigations into the use of private speech by adult English foreign language (EFL) learners in regulating their mental activities have been an interesting area of research with a sociocultural framework. Following this line of research, 30 advanced adult EFL learners were selected via the administration of Oxford quick placement test and took a…

  12. Digging Deeper into Learners' Experiences in MOOCs: Participation in Social Networks outside of MOOCs, Notetaking and Contexts Surrounding Content Consumption

    ERIC Educational Resources Information Center

    Veletsianos, George; Collier, Amy; Schneider, Emily

    2015-01-01

    Researchers describe with increasing confidence "what" they observe participants doing in massive open online courses (MOOCs). However, our understanding of learner activities in open courses is limited by researchers' extensive dependence on log file analyses and clickstream data to make inferences about learner behaviors. Further, the…

  13. More Evidence Concerning the Aspect Hypothesis: The Acquisition of English Progressive Aspect by Catalan-Spanish Instructed Learners

    ERIC Educational Resources Information Center

    Munoz, Carmen; Gilabert, Roger

    2011-01-01

    A robust finding from studies investigating the Aspect Hypothesis is that learners at the early stages of acquisition show a strong preference for using the progressive aspect as associated with activity verbs. As they advance in their acquisition of the second or foreign language, learners move from this prototypical association to associations…

  14. Learning at a Distance through Mobile Devices: A Global Choice of Learners in the Open and Distance Learning (ODL) System

    ERIC Educational Resources Information Center

    Sethy, Satya

    2011-01-01

    In the techno-driven world, mobile learning is an indispensable element of teaching-learning activities. It helps distance learners in many ways by providing their required facilities. The paper discusses about these facilities in an eclectic and summary manner. Thus, by implication, it is popularized among distance learners across the globe.…

  15. Learner-Formulated Questions in Technology-Supported Learning Applications.

    ERIC Educational Resources Information Center

    Heinrich, Eva; Johnson, Russell; Luo, Daoshui; Maurer, Hermann; Sapper, Marianne

    This paper looks at learner-formulated questions in technology-supported learning applications. Traditionally, technology-supported learning applications request input from the learner. The learner's response is used to assess the knowledge of the learner, to define a navigation path through the material or to construct a learner model. The…

  16. Similarities and differences in brain activation and functional connectivity in first and second language reading: evidence from Chinese learners of English.

    PubMed

    Cao, Fan; Young Kim, Say; Liu, Yanni; Liu, Li

    2014-10-01

    It has been evidenced that both similarities and differences exist in the brain network involved in second language reading in comparison to the first language reading. However, very few studies have been done to compare functional connectivity in L1 and L2 reading. Brain activation and functional connectivity during English pseudoword rhyming judgment in a group of late Chinese-English bilinguals (the CE group) were compared to a Chinese word rhyming judgment task in another group of late Chinese-English bilinguals (the CC group). Brain activation analyses revealed that the two groups engaged a similar network and that the only significant group difference was greater involvement of the right middle occipital gyrus in the CC group than in the CE group, due to greater holistic visuospatial processing of Chinese characters. English pseudowords can be read using the same network as Chinese characters, whereas psychophysiological interaction (PPI) analyses revealed different connectivity within the reading network between the two groups. Greater functional connectivity was found between three visuo-orthographic seed regions and the right precentral gyrus in the CC group, suggesting that the sensorimotor patterns of Chinese syllables are activated during Chinese word rhyming judgment. In contrast, we found greater connectivity between the three seed regions and the left postcentral gyrus in the CE group. In addition, the connectivity between one of the three seed regions (i.e. the right middle occipital gyrus) and the left postcentral gyrus was positively correlated with English proficiency in the CE group. This suggests that somatosensory feedback plays a key role in processing the foreign phonemes of English pseudowords and those highly proficient bilinguals tend to rely on this information to a greater degree. We also found that within the CE group, the connectivity between the right middle occipital gyrus and the left inferior parietal lobule was positively

  17. The Redox Cycler Plasmodione Is a Fast-Acting Antimalarial Lead Compound with Pronounced Activity against Sexual and Early Asexual Blood-Stage Parasites

    PubMed Central

    Ehrhardt, Katharina; Deregnaucourt, Christiane; Goetz, Alice-Anne; Tzanova, Tzvetomira; Gallo, Valentina; Arese, Paolo; Pradines, Bruno; Adjalley, Sophie H.; Bagrel, Denyse; Blandin, Stephanie; Lanzer, Michael

    2016-01-01

    Previously, we presented the chemical design of a promising series of antimalarial agents, 3-[substituted-benzyl]-menadiones, with potent in vitro and in vivo activities. Ongoing studies on the mode of action of antimalarial 3-[substituted-benzyl]-menadiones revealed that these agents disturb the redox balance of the parasitized erythrocyte by acting as redox cyclers—a strategy that is broadly recognized for the development of new antimalarial agents. Here we report a detailed parasitological characterization of the in vitro activity profile of the lead compound 3-[4-(trifluoromethyl)benzyl]-menadione 1c (henceforth called plasmodione) against intraerythrocytic stages of the human malaria parasite Plasmodium falciparum. We show that plasmodione acts rapidly against asexual blood stages, thereby disrupting the clinically relevant intraerythrocytic life cycle of the parasite, and furthermore has potent activity against early gametocytes. The lead's antiplasmodial activity was unaffected by the most common mechanisms of resistance to clinically used antimalarials. Moreover, plasmodione has a low potential to induce drug resistance and a high killing speed, as observed by culturing parasites under continuous drug pressure. Drug interactions with licensed antimalarial drugs were also established using the fixed-ratio isobologram method. Initial toxicological profiling suggests that plasmodione is a safe agent for possible human use. Our studies identify plasmodione as a promising antimalarial lead compound and strongly support the future development of redox-active benzylmenadiones as antimalarial agents. PMID:27297478

  18. Glucocorticoid acts on a putative G protein-coupled receptor to rapidly regulate the activity of NMDA receptors in hippocampal neurons.

    PubMed

    Zhang, Yanmin; Sheng, Hui; Qi, Jinshun; Ma, Bei; Sun, Jihu; Li, Shaofeng; Ni, Xin

    2012-04-01

    Glucocorticoids (GCs) have been demonstrated to act through both genomic and nongenomic mechanisms. The present study demonstrated that corticosterone rapidly suppressed the activity of N-methyl-D-aspartate (NMDA) receptors in cultured hippocampal neurons. The effect was maintained with corticosterone conjugated to bovine serum albumin and blocked by inhibition of G protein activity with intracellular GDP-β-S application. Corticosterone increased GTP-bound G(s) protein and cyclic AMP (cAMP) production, activated phospholipase Cβ(3) (PLC-β(3)), and induced inositol-1,4,5-triphosphate (IP(3)) production. Blocking PLC and the downstream cascades with PLC inhibitor, IP(3) receptor antagonist, Ca(2+) chelator, and protein kinase C (PKC) inhibitors prevented the actions of corticosterone. Blocking adenylate cyclase (AC) and protein kinase A (PKA) caused a decrease in NMDA-evoked currents. Application of corticosterone partly reversed the inhibition of NMDA currents caused by blockage of AC and PKA. Intracerebroventricular administration of corticosterone significantly suppressed long-term potentiation (LTP) in the CA1 region of the hippocampus within 30 min in vivo, implicating the possibly physiological significance of rapid effects of GC on NMDA receptors. Taken together, our results indicate that GCs act on a putative G protein-coupled receptor to activate multiple signaling pathways in hippocampal neurons, and the rapid suppression of NMDA activity by GCs is dependent on PLC and downstream signaling.

  19. Modeling the effects of multicontextual physics instruction on learner expectations and understanding of force and motion systems

    NASA Astrophysics Data System (ADS)

    Deese Becht, Sara-Maria Francis

    1999-11-01

    The purpose of this study is two-fold involving both practical and theoretical modeling components. The practical component, an experiential-learning phase, investigated a study population for effects that increasing levels of multicontextual physics activities have on student understanding of Newtonian systems of motion. This contextual-learning model measured learner convictions and non-response gaps and analyzed learner response trends on context, technology, challenge, growth, and success. The theoretical component, a model-building phase, designed a dynamic-knowing model for learning along a range of experiential tasks, from low to high context, monitored for indicators of learning in science and mathematics: learner academic performance and ability, learner control and academic attitude, and a learner non- response gap. This knowing model characterized a learner's process-of-knowing on a less to more expert- like learner-response continuum using performance and perspective indices associated with level of contextual- imagery referent system. Data for the contextual-learning model were collected on 180 secondary subjects: 72 middle and 108 high, with 36 physics subjects as local experts. Subjects were randomly assigned to one of three experimental groups differing only on context level of force and motion activities. Three levels of information were presented through context-based tasks: momentum constancy as inertia, momentum change as impulse, and momentum rate of change as force. The statistical analysis used a multi-level factorial design with repeated measures and discriminate analysis of response-conviction items. Subject grouping criteria included school level, ability level in science and mathematics, gender and race. Assessment criteria used pre/post performance scores, confidence level in physics concepts held, and attitude towards science, mathematics, and technology. Learner indices were computed from logit- transforms applied to learner outcomes

  20. 20 CFR 667.220 - What Workforce Investment Act title I functions and activities constitute the costs of...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., utilities, office supplies, postage, and rental and maintenance of office space; (4) Travel costs incurred..., and demand occupation information; (iii) Performance and program cost information on eligible providers of training services, youth activities, and appropriate education activities; (iv) Local...

  1. 20 CFR 667.220 - What Workforce Investment Act title I functions and activities constitute the costs of...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ..., utilities, office supplies, postage, and rental and maintenance of office space; (4) Travel costs incurred..., and demand occupation information; (iii) Performance and program cost information on eligible providers of training services, youth activities, and appropriate education activities; (iv) Local...

  2. 20 CFR 667.220 - What Workforce Investment Act title I functions and activities constitute the costs of...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ..., utilities, office supplies, postage, and rental and maintenance of office space; (4) Travel costs incurred..., and demand occupation information; (iii) Performance and program cost information on eligible providers of training services, youth activities, and appropriate education activities; (iv) Local...

  3. 20 CFR 667.220 - What Workforce Investment Act title I functions and activities constitute the costs of...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ..., utilities, office supplies, postage, and rental and maintenance of office space; (4) Travel costs incurred..., and demand occupation information; (iii) Performance and program cost information on eligible providers of training services, youth activities, and appropriate education activities; (iv) Local...

  4. 20 CFR 667.220 - What Workforce Investment Act title I functions and activities constitute the costs of...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ..., utilities, office supplies, postage, and rental and maintenance of office space; (4) Travel costs incurred..., and demand occupation information; (iii) Performance and program cost information on eligible providers of training services, youth activities, and appropriate education activities; (iv) Local...

  5. Are Deaf Students Visual Learners?

    PubMed Central

    Marschark, Marc; Morrison, Carolyn; Lukomski, Jennifer; Borgna, Georgianna; Convertino, Carol

    2013-01-01

    It is frequently assumed that by virtue of their hearing losses, deaf students are visual learners. Deaf individuals have some visual-spatial advantages relative to hearing individuals, but most have been are linked to use of sign language rather than auditory deprivation. How such cognitive differences might affect academic performance has been investigated only rarely. This study examined relations among deaf college students’ language and visual-spatial abilities, mathematics problem solving, and hearing thresholds. Results extended some previous findings and clarified others. Contrary to what might be expected, hearing students exhibited visual-spatial skills equal to or better than deaf students. Scores on a Spatial Relations task were associated with better mathematics problem solving. Relations among the several variables, however, suggested that deaf students are no more likely to be visual learners than hearing students and that their visual-spatial skill may be related more to their hearing than to sign language skills. PMID:23750095

  6. Early learner perceptions of the attributes of effective preceptors.

    PubMed

    Huggett, Kathryn N; Warrier, Rugmini; Maio, Anna

    2008-12-01

    Medical education in the US has adapted to the shift of patient care from hospital to ambulatory settings by developing educational opportunities in outpatient settings. Faculty development efforts must acknowledge learners' perspectives to be effective in improving teaching and learning. Clinics provide important and unique learning opportunities, but also present different challenges for preceptors (i.e., physician teachers) and learners. Multiple studies have identified characteristics of effective preceptors of ambulatory care medicine. However, most of these studies were conducted among residents or students with clinical experience. To investigate preclinical, second-year medical students' perceptions of preceptor quality, we conducted an exploratory qualitative study using analysis of student learning journals. The purposive sample included 120 medical students in a private, Midwestern medical school in the United States. Learning journals of 110 students for two semesters were reviewed. Five attributes of an effective preceptor emerged: (1) Demonstrates professional expertise (2) Actively engages students in learning (3) Creates a positive environment for teaching and learning (4) Demonstrates collegiality and professionalism (5) Discusses career-related topics and concerns. Our findings suggest preclinical learners often begin initial clinical experiences with sophisticated definitions of professional expertise, and hold specific expectations for professionalism. These are based on previous coursework and personal experience. These expectations influence their perceptions of effective preceptors and learning experiences. Early clinical experiences can also influence perceptions about career and specialty choice. Improving our understanding of preclinical learners' perceptions of preceptor quality will improve the efficacy of faculty development efforts and learning experiences.

  7. Visualization for learners: a framework for adapting scientists' tools

    NASA Astrophysics Data System (ADS)

    Edelson, Daniel C.; Gordin, Douglas

    1998-08-01

    The use of scientific investigation tools for education is receiving considerable attention as a result of an increased emphasis in the educational community on open-ended inquiry. The scientific community possesses a treasure trove of tools that could be adapted for use by learners. Scientific visualization technologies, in particular, offer great promise for education because of the way they use visual representations to facilitate exploration of complex data. However, the tools that are used by scientists are inappropriate for learners because of their reliance on the tacit knowledge of expert users. Through a careful consideration of the differences between scientists and science students and the design of a series of scientific visualization environments for learners in grades 8-16, we have developed a design framework for the creation of scientific investigation tools based on those of scientists. The framework highlights five critical issues for the construction of tools to support inquiry-based learning: motivating context, learner-appropriate activities, data selection, scaffolding interfaces and support for learning. We have applied this framework to the design of ClimateWatcher, a scientific visualization environment for the investigation of issues related to global climate and climate change that is now in use in middle school, high school and university settings.

  8. Constructing a Scale to Assess L2 Written Speech Act Performance: WDCT and E-Mail Tasks

    ERIC Educational Resources Information Center

    Chen, Yuan-shan; Liu, Jianda

    2016-01-01

    This study reports the development of a scale to evaluate the speech act performance by intermediate-level Chinese learners of English. A qualitative analysis of the American raters' comments was conducted on learner scripts in response to a total of 16 apology and request written discourse completion task (WDCT) situations. The results showed…

  9. ADP-Ribosylation Factor 6 Acts as an Allosteric Activator for the Folded but not Disordered Cholera Toxin A1 Polypeptide

    PubMed Central

    Banerjee, Tuhina; Taylor, Michael; Jobling, Michael G.; Burress, Helen; Yang, ZhiJie; Serrano, Albert; Holmes, Randall K.; Tatulian, Suren A.; Teter, Ken

    2014-01-01

    Summary The catalytic A1 subunit of cholera toxin (CTA1) has a disordered structure at 37°C. An interaction with host factors must therefore place CTA1 in a folded conformation for the modification of its Gsα target which resides in a lipid raft environment. Host ADP-ribosylation factors (ARFs) act as in vitro allosteric activators of CTA1, but the molecular events of this process are not fully characterized. Isotope-edited Fourier transform infrared spectroscopy monitored ARF6-induced structural changes to CTA1, which were correlated to changes in CTA1 activity. We found ARF6 prevents the thermal disordering of structured CTA1 and stimulates the activity of stabilized CTA1 over a range of temperatures. Yet ARF6 alone did not promote the refolding of disordered CTA1 to an active state. Instead, lipid rafts shifted disordered CTA1 to a folded conformation with a basal level of activity that could be further stimulated by ARF6. Thus, ARF alone is unable to activate disordered CTA1 at physiological temperature: additional host factors such as lipid rafts place CTA1 in the folded conformation required for its ARF-mediated activation. Interaction with ARF is required for in vivo toxin activity, as enzymatically active CTA1 mutants that cannot be further stimulated by ARF6 fail to intoxicate cultured cells. PMID:25257027

  10. The Young Learner.

    ERIC Educational Resources Information Center

    Bonini, Victor

    1987-01-01

    Stresses the need for young children to understand that wild animals should not be kept for pets. Provides lesson plans for physical education, music, and science. Includes suggestions for bulletin boards and learning centers, and a clip art set with figures that are suitable for use with the activities. (TW)

  11. Dose determination of the persistent activity of moxidectin long-acting injectable formulations against various nematode species in cattle.

    PubMed

    Yazwinski, T A; Williams, J C; Smith, L L; Tucker, C; Loyacano, A F; Derosa, A; Peterson, P; Bruer, D J; Delay, R L

    2006-04-30

    The effectiveness, safety and production-enhancing benefit (improved weight gains) of moxidectin long-acting injection given subcutaneously in the ear at the rates of 0.75, 1.0 and 1.5mg/kg bw were evaluated in three studies under common protocol. The only adverse reaction to treatment was a mild (<2 tablespoons in volume), and for the most part transient (<28 days for the treatment rate of 1.0mg/kg bw) injection site swelling as noted in a minority of the animals (12.2% of the animals treated at the rate of 1.0mg/kg bw). Regardless of study site, post-treatment interval or dose rate, average daily gains were improved over control cattle by approximately 33%. Reductions in strongyle EPG counts relative to controls were > or = 90% for all dose rates of moxidectin for a post-treatment period of 42 days (Wisconsin), 84 days (Arkansas) and 140 days (Louisiana). In Arkansas and Louisiana, the majority (>80%) of post-treatment strongyle eggs, as determined by coproculture, were Cooperia spp. As determined by sequential necropsies, periods of continuous, post-treatment protection (> or = 90% efficacy in at least two out of three studies) for moxidectin long-acting injection given at the rate of 1.0 mg/kg bw were 90 days (adult Haemonchus spp.), 120 days (Dictyocaulus viviparus and adult Ostertagia and Oesophagostomum) and 150 days (Ostertagia spp. EL4).

  12. Potentiation of local anesthetic activity of neosaxitoxin with bupivacaine or epinephrine: development of a long-acting pain blocker.

    PubMed

    Rodriguez-Navarro, Alberto J; Lagos, Marcelo; Figueroa, Cristian; Garcia, Carlos; Recabal, Pedro; Silva, Pamela; Iglesias, Veronica; Lagos, Nestor

    2009-11-01

    Local anesthetics effectively block and relieve pain, but with a relatively short duration of action, limiting its analgesic effectiveness. Therefore, a long-acting local anesthetic would improve the management of pain, but no such agent is yet available for clinical use. The aim of this study is to evaluate the potentiation of the anesthetic effect of neosaxitoxin, with bupivacaine or epinephrine in a randomized double-blind clinical trial. Ten healthy males were subcutaneously injected into the left and right forearms with a randomized pair of the following treatments: (i) bupivacaine (5 mg); (ii) neosaxitoxin (10 microg); (iii) neosaxitoxin (10 microg) plus bupivacaine (5 mg), and (iv) neosaxitoxin (10 microg) plus epinephrine (1:100.000), but all participant received all four formulations (in 2 ml; s.c.), with 1 month elapsing between the two round of experiments. A validated sensory and pain paradigm was used for evaluating the effect of the treatment 0-72 h after the injections, measuring sensory, pain, and mechanical touch perception threshold. The duration of the effect produced by combined treatments was longer than that by the single drugs. In conclusion, bupivacaine and epinephrine potentiate the local anesthetic effect of neosaxitoxin in humans when co-injected subcutaneously. The present results support the idea that neosaxitoxin is a new long-acting local pain blocker, with highly potential clinical use.

  13. A liver X receptor (LXR)-{beta} alternative splicing variant (LXRBSV) acts as an RNA co-activator of LXR-{beta}

    SciTech Connect

    Hashimoto, Koshi; Ishida, Emi; Matsumoto, Shunichi; Shibusawa, Nobuyuki; Okada, Shuichi; Monden, Tsuyoshi; Satoh, Tetsurou; Yamada, Masanobu; Mori, Masatomo

    2009-12-25

    We report the isolation and functional characterization of a novel transcriptional co-activator, termed LXRBSV. LXRBSV is an alternative splicing variant of liver X receptor (LXR)-{beta} LXRBSV has an intronic sequence between exons 2 and 3 in the mouse LXR-{beta} gene. The LXRBSV gene is expressed in various tissues including the liver and brain. We sub-cloned LXRBSV into pSG5, a mammalian expression vector, and LXRBSV in pSG5 augmented human Sterol Response Element Binding Protein (SREBP)-1c promoter activity in HepG2 cells in a ligand (TO901317) dependent manner. The transactivation mediated by LXRBSV is selective for LXR-{beta}. The LXRBSV protein was deduced to be 64 amino acids in length; however, a GAL4-LXRBSV fusion protein was not able to induce transactivation. Serial deletion constructs of LXRBSV demonstrated that the intronic sequence inserted in LXRBSV is required for its transactivation activity. An ATG mutant of LXRBSV was able to induce transactivation as wild type. Furthermore, LXRBSV functions in the presence of cycloheximide. Taken together, we have concluded that LXRBSV acts as an RNA transcript not as a protein. In the current study, we have demonstrated for the first time that an alternative splicing variant of a nuclear receptor acts as an RNA co-activator.

  14. Recasts, Metalinguistic Feedback, and Learners' Perceptions: A Case of Persian EFL Learners

    ERIC Educational Resources Information Center

    Rassaei, Ehsan; Moinzadeh, Ahmad

    2014-01-01

    In the current study, we present the results of an experiment with 30 Persian EFL learners in which we explored the learners' perceptions of recasts and metalinguistic corrective feedback. The participant learners received either recasts or metalinguistic feedback for their errors during task-based interactions with their interlocutors and then…

  15. The Attitudes of Field Dependence Learners for Learner Interface Design (LID) in e-Learning Instruction

    ERIC Educational Resources Information Center

    Sözcü, Ömer Faruk; Ipek, Ismail; Kinay, Hüseyin

    2016-01-01

    The purpose of the study is to explore relationships between learners' cognitive styles of field dependence and learner variables in the preference of learner Interface design, attitudes in e-Learning instruction and experience with e-Learning in distance education. Cognitive style has historically referred to a psychological dimension…

  16. Language Learner Strategy Use and Test Performance of Chinese Learners of English

    ERIC Educational Resources Information Center

    Song, Xiaomei; Cheng, Liying

    2006-01-01

    This article examines language learner strategy use reported by 121 Chinese learners of English through a questionnaire and the relationships between their strategy use and language performance on a national English proficiency test: College English Test-Band 4. Results showed that this group of learners reported using more metacognitive…

  17. Perceptions of a Learner's Self-Expressive Speech by an Instructor and the Learner

    ERIC Educational Resources Information Center

    Yoshida, Reiko

    2007-01-01

    Learners' spontaneous speech beyond interaction patterns such as teacher's initiation-learner's response-teacher's evaluation (I-R-E/F) (Heap, 1988; Mehan, 1979; Ohta, 1999) helps lead them to negotiated interaction (Boulima, 1999), which is effective for foreign language learning. This study examines both an instructor's and a learner's…

  18. Learner Agency in Language Learning: The Story of a Distance Learner of EFL in China

    ERIC Educational Resources Information Center

    Xiao, Junhong

    2014-01-01

    Learner agency plays a key role in self-regulated learning. Yet, there is a paucity of research into its role in the distance learning context. Using reflective narratives written by a distance learner of English in China, this longitudinal case study aims to investigate the ways in which learner agency mediates the language learning in the…

  19. Re-Awakening the Learner: Creating Learner-Centric, Standards-Driven Schools

    ERIC Educational Resources Information Center

    Stoll, Copper; Giddings, Gene

    2012-01-01

    Transformation of public education requires the reawakening of the sleeping giant in the room: the learners. Students, teachers, and principals must develop a learner-centric, standards-driven school. "Reawakening the Learner" is a guide to creating just such an environment. Continua describe the journey of teachers, teacher leaders, and…

  20. Strategy-Based Instruction: A Learner-Focused Approach to Developing Learner Autonomy

    ERIC Educational Resources Information Center

    Nguyen, Le Thi Cam; Gu, Yongqi

    2013-01-01

    This study investigates the effects of strategy-based instruction (SBI) on the promotion of learner autonomy (LA). LA was conceptualized and operationally defined as learner self-initiation and learner self-regulation. An intervention study was conducted with the participation of 37 students in an experimental group, and 54 students in two control…

  1. Learner Councils in South African Schools: Adult Involvement and Learners' Rights

    ERIC Educational Resources Information Center

    Hunt, Frances

    2014-01-01

    Each secondary school in South Africa is legally obliged to establish a representative council of learners, a democratically elected, learner-only council. This article looks at how the representative councils of learners are realised in practice in four secondary schools. Three research questions focus on the practice of representative councils…

  2. The effectiveness of physical activity monitoring and distance counselling in an occupational health setting - a research protocol for a randomised controlled trial (CoAct)

    PubMed Central

    2009-01-01

    Background The CoAct (Cocreating Activity) study is investigating a novel lifestyle intervention, aimed at the working population, with daily activity monitoring and distance counselling via telephone and secure web messages. The main purpose of this study is to evaluate the effectiveness of lifestyle counselling on the level of physical activity in an occupational health setting. The purposes include also analysing the potential effects of changes in physical activity on productivity at work and sickness absence, and healthcare costs. This article describes the design of the study and the participant flow until and including randomization. Methods/Design CoAct is a randomised controlled trial with two arms: a control group and intervention group with daily activity monitoring and distance counselling. The intervention focuses on lifestyle modification and takes 12 months. The study population consists of volunteers from 1100 eligible employees of a Finnish insurance company. The primary outcomes of this study are change in physical activity measured in MET minutes per week, work productivity and sickness absence, and healthcare utilisation. Secondary outcomes include various physiological measures. Cost-effectiveness analysis will also be performed. The outcomes will be measured by questionnaires at baseline, after 6, 12, and 24 months, and sickness absence will be obtained from the employer's registers. Discussion No trials are yet available that have evaluated the effectiveness of daily physical activity monitoring and distance counselling in an occupational health setting over a 12 month period and no data on cost-effectiveness of such intervention are available. Trial Registration ClinicalTrials.gov identifier: NCT00994565 PMID:20043831

  3. Potassium Acts as a GTPase-Activating Element on Each Nucleotide-Binding Domain of the Essential Bacillus subtilis EngA

    PubMed Central

    Foucher, Anne-Emmanuelle; Reiser, Jean-Baptiste; Ebel, Christine; Housset, Dominique; Jault, Jean-Michel

    2012-01-01

    EngA proteins form a unique family of bacterial GTPases with two GTP-binding domains in tandem, namely GD1 and GD2, followed by a KH (K-homology) domain. They have been shown to interact with the bacterial ribosome and to be involved in its biogenesis. Most prokaryotic EngA possess a high GTPase activity in contrast to eukaryotic GTPases that act mainly as molecular switches. Here, we have purified and characterized the GTPase activity of the Bacillus subtilis EngA and two shortened EngA variants that only contain GD1 or GD2-KH. Interestingly, the GTPase activity of GD1 alone is similar to that of the whole EngA, whereas GD2-KH has a 150-fold lower GTPase activity. At physiological concentration, potassium strongly stimulates the GTPase activity of each protein construct. Interestingly, it affects neither the affinities for nucleotides nor the monomeric status of EngA or the GD1 domain. Thus, potassium likely acts as a chemical GTPase-activating element as proposed for another bacterial GTPase like MnmE. However, unlike MnmE, potassium does not promote dimerization of EngA. In addition, we solved two crystal structures of full-length EngA. One of them contained for the first time a GTP-like analogue bound to GD2 while GD1 was free. Surprisingly, its overall fold was similar to a previously solved structure with GDP bound to both sites. Our data indicate that a significant structural change must occur upon K+ binding to GD2, and a comparison with T. maritima EngA and MnmE structures allowed us to propose a model explaining the chemical basis for the different GTPase activities of GD1 and GD2. PMID:23056455

  4. Candles, Corks and Contracts: Essential Relationships between Learners and Libraries.

    ERIC Educational Resources Information Center

    Burge, Elizabeth J.; Snow, Judith E.

    2000-01-01

    Current relationships between libraries and adult learners are shaped by technology adoption, learner demographics, constructivist learning, and institutional pressures. Future relationships must emphasize learner-centered action over technological efficiency, stronger learning leadership, and greater integration of libraries in educational…

  5. Exploring Lifelong Learners Engaged in an Astronomy-Related Massively Open Online Course

    NASA Astrophysics Data System (ADS)

    Buxner, Sanlyn; Impey, Chris David; Wenger, Matthew; Formanek, Martin; Romine, James M.

    2016-01-01

    Massively open online courses (MOOCs) are becoming increasingly popular ways to reach diverse lifelong learners all over the world. Although MOOCs resemble more formal classes (e.g. videos of content, quizzes, activities), they are often used by informal audiences from home. Recently, MOOCs have become more utilized by universities to conduct outreach as they explore how to use MOOCs to reach new potential learners. Despite the rapid adaption of MOOCs, little is known about individuals who choose to take a MOOC, how they interact with the course materials, and what motivates them to finish the course.We present results of a study of lifelong learners engaged in an astronomy "101" MOOC. Through analysis of registered learners' behaviors as well as self-reported responses to a survey about science, we were able to characterize a subset of the learners engaged in the MOOC during its first offering. Overall, 25363 learners from over 100 countries registered for the MOOC. Of those, 14900 accessed at least one part of the course. Learners were recruited to complete a survey of their knowledge and attitudes towards science. Of the learner group who opened the course, 2889 individuals completed the survey, 2465 of those were able to be linked to their usage of the MOOC through a unique identifier.Learners represented a wide-range of ages, professions, and previous science experience. The best predictors for MOOC completion were engagement in the first activity and first writing assignment and engagement in the online forum. Learners were very interested in science prior to their registration, had higher basic science knowledge that most undergraduate students enrolled in a parallel astronomy course, and used online searches and science sites to get their information about science. As we reach out to a worldwide audience to learners in these massively open online courses, understanding their motivations and behaviors will be essential. This work is helping us understand and

  6. Balancing Act

    ERIC Educational Resources Information Center

    Kennedy, Mike

    2007-01-01

    For some administrators and planners, designing and building education facilities may sometimes seem like a circus act--trying to project a persona of competence and confidence while juggling dozens of issues. Meanwhile, the audience--students, staff members and taxpayers--watch and wait with anticipation in hopes of getting what they paid for and…

  7. Abnormal sperm in mice with targeted deletion of the act (activator of cAMP-responsive element modulator in testis) gene

    PubMed Central

    Kotaja, Noora; De Cesare, Dario; Macho, Betina; Monaco, Lucia; Brancorsini, Stefano; Goossens, Ellen; Tournaye, Herman; Gansmuller, Anne; Sassone-Corsi, Paolo

    2004-01-01

    ACT [activator of cAMP-responsive element modulator (CREM) in testis] is a LIM-only protein that interacts with transcription factor CREM in postmeiotic male germ cells and enhances CREM-dependent transcription. CREM regulates many crucial genes required for spermatid maturation, and targeted mutation of the Crem gene in the mouse germ-line blocks spermatogenesis. Here we report the phenotype of mice in which targeted disruption of the act gene was obtained by homologous recombination. Whereas the seminiferous tubules of the act–/– mice contain all of the developmental stages of germ cells and the mice are fertile, the amount of mature sperm in the epididymis is drastically reduced. The residual sperm display severe abnormalities, including fully folded tails and aberrant head shapes. These results indicate that numerous postmeiotic genes under CREM control require the coactivator function of ACT. Thus, the fine-tuning of sperm development is achieved by the coordinated action of two transcriptional regulators. PMID:15247423

  8. Learner Satisfaction in Online Learning: An Analysis of the Perceived Impact of Learner-Social Media and Learner-Instructor Interaction

    ERIC Educational Resources Information Center

    Andersen, Jeffery C.

    2013-01-01

    The purpose of this study was to determine the relationships between general course satisfaction, learner-instructor interaction, and the learner-social media interaction scores of participants. This study used an online survey with 60 questions to gather the participants' demographic data, learner-instructor interaction data, learner-social…

  9. Adult learner centered processes in an online ADRN to BSN nursing program: independent evaluator and peer self-assessments.

    PubMed

    Shuster, George; Birkholz, Gloria; Petri, Linda

    2007-01-01

    A five year fully online RN to BSN program was assessed by faculty and a consultant using the Robert Wood Johnson Foundation's Partnerships for Training (PFT) learner-centered evaluation tool. Faculty were more critical of their expertise in learner-centered online course criteria than the consultant. The consultant identified minimal use of peer support, collaborative activities, faculty preference for visual learner activities, and a tendency toward faculty ownership of learning goals and creation of activity rules and guidelines. The need to bring online discussions to a higher level of thinking was also noted. The dual evaluation perspectives helped identify strengths and weaknesses in the curriculum.

  10. Effects beyond Effectiveness: Teaching as a Performative Act

    ERIC Educational Resources Information Center

    Liew, Warren Mark

    2013-01-01

    This article develops the familiar metaphor of teaching as performance towards a definition of "teaching as performative act," where words and actions aim to effect cognitive, affective, and behavioral changes in learners. To what extent, however, are the consequences of pedagogical actions commensurate with their intended effects? Can a science…

  11. Learner-Generated Noticing Behavior by Novice Learners: Tracing the Effects of Learners' L1 on Their Emerging L2

    ERIC Educational Resources Information Center

    Park, Eun Sung

    2013-01-01

    This study examines novice learners' self-generated input noticing approaches and strategies. It is motivated by previous research on input enhancement which yielded insights that learners are naturally prone to notice certain aspects of L2 input on their own without any external means to channel their attention. Two L1 groups (Japanese and…

  12. 50 CFR 80.51 - What activities are eligible for funding under the Dingell-Johnson Sport Fish Restoration Act?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... populations due to fishing, other human activities, or natural causes; and (iii) Effects of any measures or... opportunities. (2) Increase participation in sport fishing and boating. (3) Advance the adoption of...

  13. 50 CFR 80.51 - What activities are eligible for funding under the Dingell-Johnson Sport Fish Restoration Act?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... populations due to fishing, other human activities, or natural causes; and (iii) Effects of any measures or... opportunities. (2) Increase participation in sport fishing and boating. (3) Advance the adoption of...

  14. Sea Changes - ACT : Artists and Scientists collaborating to promote ocean activism and conservation. (www.seachanges.org)

    NASA Astrophysics Data System (ADS)

    Lueker, T.

    2012-12-01

    We are a group of ocean scientists, artists, and educators working to publicize the urgent environmental problems facing our ocean environs, including overfishing, climate change and ocean acidification, and environmental degradation due to plastic and other forms of pollution. Our team leader, Kira Carrillo Corser, is an artist and educator known nationally for affecting policy and social change. Our collaboration results from the DNA of Creativity Project - the brainchild of Patricia Frischer, co-ordinator for the San Diego Visual Arts Network (http://dnaofc.weebly.com). The DNA of Creativity funded teams composed of artists and scientists with the goal of fusing the creative energies of both into projects that will enhance the public's perception of creativity, and make the complexities of art and science collaborations accessible to a new and larger audience. Sea Changes - ACT was funded initially by the DNA of Creativity Project. Our project goals are : 1) To entice people to participate in the joys of discovery of art AND science and 2) To motivate the public to work for real, committed and innovative change to protect our oceans. Part of our strategy for achieving our goals is to create a traveling art installation to illustrate the beauty of the oceans and to instill in our viewers the joys of discovery and creativity that we as scientists and artists pursue. And following this, to make the destructive changes occurring in the ocean and the future consequences more visible and understandable. We will develop lesson plans to integrate our ideas into the educational system and we are documenting our collaborative and creative process to inform future art-science collaborations. Finally, after emotionally connecting with our viewers to provide a means to ACT to make real and positive CHANGES for the future. Our project aims to build commitment and action for environmental conservation and stewardship as we combine scientific research with ways to take action

  15. Pairing Learners in Pair Work Activity

    ERIC Educational Resources Information Center

    Storch, Neomy; Aldosari, Ali

    2013-01-01

    Although pair work is advocated by major theories of second language (L2) learning and research findings suggest that pair work facilitates L2 learning, what is unclear is how to best pair students in L2 classes of mixed L2 proficiency. This study investigated the nature of pair work in an English as a Foreign Language (EFL) class in a college in…

  16. TMF and glycitin act synergistically on keratinocytes and fibroblasts to promote wound healing and anti-scarring activity

    PubMed Central

    Seo, Ga Young; Lim, Yoongho; Koh, Dongsoo; Huh, Jung Sik; Hyun, Changlim; Kim, Young Mee; Cho, Moonjae

    2017-01-01

    Keratinocyte-fibroblast interactions are critical for skin repair after injury. During the proliferative phase of wound healing, proliferation, migration and differentiation of these cells are the major mechanisms leading to tissue remodeling. We have previously reported that glycitin, a major soy isoflavone, stimulates dermal fibroblast proliferation; and the phytochemical, 4′,6,7-trimethoxyisoflavone (TMF), induces migration of HaCaT keratinocyte cells. We therefore investigated whether these compounds display synergistic effects on skin cells during wound healing in vitro and in vivo. Co-treatment with TMF and glycitin synergistically promotes the proliferation and migration of both keratinocytes and dermal fibroblasts, with a 1:1 ratio of these compounds showing the greatest efficacy in our co-culture system. This keratinocyte-fibroblast interaction occurred via the secretion of TGF-β, and the induction of differentiation and proliferation was confirmed in both indirect and direct co-culture assays. In an excisional and burn wound animal model, mice treated with a 1:1 ratio of TMF and glycitin showed faster wound closure, regeneration and scar reduction than even the positive control drug. These data indicate that two isoflavones, TMF and glycitin, act synergistically to promote wound healing and anti-scarring and could potentially be developed together as a bioactive therapeutic for wound treatment. PMID:28303029

  17. Acting Their Age

    ERIC Educational Resources Information Center

    DiConsiglio, John

    2010-01-01

    Between 42 and 45 percent of American students are "adult learners." They're over 25. They're returning to school for career change more than career advancement. And they're challenging the educational world to understand and meet their needs. Educational institutions have adult learners squarely on their radars. Over-25s are among the fastest…

  18. Verification of the in vivo activity of three distinct cis-acting elements within the Gata1 gene promoter-proximal enhancer in mice.

    PubMed

    Shimizu, Ritsuko; Hasegawa, Atsushi; Ottolenghi, Sergio; Ronchi, Antonella; Yamamoto, Masayuki

    2013-11-01

    The transcription factor GATA1 is essential for erythroid and megakaryocytic cell differentiation. Gata1 hematopoietic regulatory domain (G1HRD) has been shown to recapitulate endogenous Gata1 gene expression in transgenic mouse assays in vivo. G1HRD contains a promoter-proximal enhancer composed of a GATA-palindrome motif, four CP2-binding sites and two CACCC boxes. We prepared transgenic reporter mouse lines in which green fluorescent protein and β-galactosidase expression are driven by wild-type G1HRD (as a positive control) and the G1HRD harboring mutations within these cis-acting elements (as the experimental conditions), respectively. Exploiting this transgenic dual reporter (TDR) assay, we show here that in definitive erythropoiesis, G1HRD activity was markedly affected by individual mutations in the GATA-palindrome motif and the CACCC boxes. Mutation of CP2-binding sites also moderately decreased G1HRD activity. The combined mutation of the CP2-binding sites and the GATA-palindrome motif resulted in complete loss of G1HRD activity. In contrast, in primitive erythroid cells, individual mutations of each element did not affect G1HRD activity; G1HRD activity was abolished only when these three mutations were combined. These results thus show that all three elements independently and cooperatively contribute to G1HRD activity in vivo in definitive erythropoiesis, although these are contributing redundantly to primitive erythropoiesis.

  19. WAC regulates mTOR activity by acting as an adaptor for the TTT and Pontin/Reptin complexes

    PubMed Central

    David-Morrison, Gabriela; Xu, Zhen; Rui, Yan-Ning; Charng, Wu-Lin; Jaiswal, Manish; Yamamoto, Shinya; Xiong, Bo; Zhang, Ke; Sandoval, Hector; Duraine, Lita; Zuo, Zhongyuan; Zhang, Sheng; Bellen, Hugo J.

    2015-01-01

    SUMMARY The ability to sense energy status is crucial in the regulation of metabolism via the mechanistic Target of Rapamycin Complex 1 (mTORC1). The assembly of the TTT-Pontin/Reptin complex is responsive to changes in energy status. In energy sufficient conditions, the TTT-Pontin/Reptin complex promotes mTORC1 dimerization and mTORC1-Rag interaction, which are critical for mTORC1 activation. We show that WAC is a regulator of energy-mediated mTORC1 activity. In a Drosophila screen designed to isolate mutations that cause neuronal dysfunction, we identified wacky, the homolog of WAC. Loss of Wacky leads to neurodegeneration, defective mTOR activity and increased autophagy. Wacky and WAC have conserved physical interactions with mTOR and its regulators, including Pontin and Reptin which bind to the TTT complex to regulate energy-dependent activation of mTORC1. WAC promotes the interaction between TTT and Pontin/Reptin in an energy-dependent manner, thereby promoting mTORC1 activity by facilitating mTORC1 dimerization and mTORC1-Rag interaction. PMID:26812014

  20. Effect of triterpenoids on the inflammation induced by protein kinase C activators, neuronally acting irritants and other agents.

    PubMed

    Huguet, A; del Carmen Recio, M; Máñez, S; Giner, R; Ríos, J

    2000-12-20

    In order to establish the mode of the anti-inflammatory activity of triterpenoids, 11 naturally occurring compounds were assayed on mouse ear oedema induced by the protein kinase C activators, mezerein, 12-O-tetradecanoylphorbol-13-acetate (TPA), two 12-deoxyphorbol-13-monoesters (13-tetradecanoate (DPT) and 13-phenylacetate (DPP)) and bryostatin 1, and by resiniferatoxin, xylene and arachidonic acid. The effects on bradykinin-induced paw oedema and on the rat skin inflammation caused by hydrogen peroxide were also examined. The oedema induced by mezerein and DPT was reduced to different extents by the triterpenoids administered epicutaneously (0.5 mg per ear). Against DPT-induced oedema, lupane and oleanane derivatives were the most effective compounds. Oleananes and lupanes possessing a carboxyl group were active against bryostatin 1-induced oedema. Most of the triterpenoids were ineffective against the neurogenic inflammation caused by resiniferatoxin and xylene. Many triterpenoids, especially oleanane and lupane alcoholic derivatives, were active against the plantar oedema induced by bradykinin and on the intradermal inflammation induced by hydrogen peroxide. In conclusion, the anti-inflammatory activity of triterpenoids may depend on inhibition of protein kinase C, without any involvement of neurogenic inflammatory mechanisms.

  1. Coping with Demotivation: EFL Learners' Remotivation Processes

    ERIC Educational Resources Information Center

    Falout, Joseph

    2012-01-01

    When foreign language education is compulsory, competitive, or coercive, how learners cope with stress can determine outcomes, including value of the subject, persistence on task, and level of proficiency. The development of adaptive or maladaptive coping processes toward situated learning goals is influenced by learners' beliefs about themselves…

  2. Successfully Applying Team Teaching with Adult Learners

    ERIC Educational Resources Information Center

    Laughlin, Kevin; Nelson, Peggy; Donaldson, Susan

    2011-01-01

    Team teaching is a great strategy to convey systems thinking to students, families, and communities and to help learners gain multiple perspectives. Learners benefit from the professional interaction among skilled instructors. This article uses a program of land stewardship to demonstrate the advantages of team teaching. Both the advantages and…

  3. English Learners (ELs) and NAEP. Fast Facts

    ERIC Educational Resources Information Center

    Office of English Language Acquisition, US Department of Education, 2015

    2015-01-01

    The Office of English Language Acquisition (OELA) has synthesized key data on English learners (ELs) into two-page PDF sheets, by topic, with graphics, plus key contacts. The topics for this report on English Learners (ELs) and NAEP include: (1) 2013 Reading Scores for Grades 4, 8, and 12: ELs vs. Non-ELs; (2) 2013 Mathematics Scores for Grades 4,…

  4. Iranian University English Learners' Discursive Demotivation Construction

    ERIC Educational Resources Information Center

    Rashidi, Nasser; Rahimi, Mohammad; Alimorad, Zahra

    2014-01-01

    Investigating how foreign language learners' discourse mediates their demotivation construction is a relatively new area of inquiry. This paper examined the discursive construction of four (two males and two females) Iranian English as a Foreign Language (EFL) learners' demotivation at Shiraz University, Iran. Employing Fairclough's (2003)…

  5. Profiles of English Learners (ELs). Fast Facts

    ERIC Educational Resources Information Center

    Office of English Language Acquisition, US Department of Education, 2015

    2015-01-01

    The Office of English Language Acquisition (OELA) has synthesized key data on English learners (ELs) into two-page PDF sheets, by topic, with graphics, plus key contacts. The topics for this report on profiles of English Learners (ELs) include: (1) Percentage of Total School Population, Grades Pre-K through 12, Represented by ELs, by State,…

  6. Adult Language Learners: Context and Innovation

    ERIC Educational Resources Information Center

    Smith, Ann F. V., Ed.; Strong, Gregory, Ed.

    2009-01-01

    "Adult Language Learners: Context and Innovation" presents instructional practices that are particularly successful with adults. Adult language learners are goal oriented and direct their learning to fulfill particular needs or demands: to advance their studies, to progress up the career ladder, to follow business opportunities, to pass…

  7. Training Learners for Self-Instruction.

    ERIC Educational Resources Information Center

    Fernandez-Toro, Maria

    This book presents practical solutions for teaching foreign language learners self instruction, ranging from needs analysis to resourcing, strategy training and monitoring tools. Special emphasis is placed on different ways in which learners can be supported by learning how to analyze their own needs and set their own goals, how to choose the most…

  8. Model Learner Outcomes for Home Economics Education.

    ERIC Educational Resources Information Center

    Rogers, Cheryl, Ed.; And Others

    Chapter 1 of this document contains sets of statements adopted by either the Minnesota State Board of Education or the Minnesota State Legislature. They represent the hierarchy used by Department of Education staff as they develop model learner outcomes for each subject area. Contents include learner values, education system values, philosophy for…

  9. Prospective Teachers' Metaphorical Conceptualizations of Learner

    ERIC Educational Resources Information Center

    Saban, Ahmet

    2010-01-01

    This study investigated the metaphorical images that prospective teachers in Turkey formulated to describe learners. Participants (N = 2847) completed the prompt "A student is like ... because ..." to indicate their conceptualizations of learner. Data were analyzed both qualitatively and quantitatively. Altogether 98 well-articulated…

  10. Build Optional Digital Textbooks for Distance Learners

    ERIC Educational Resources Information Center

    Ruo, Du; Xiaotang, Yang

    2013-01-01

    E-books seem to be a trend and an excellent solution for mobile learning lately, but what kinds of e-books are good fit for distance learners' needs? For the purpose of offering open, more appropriate, better in quality, more convenient and flexible learning materials for distance learners. From 2011, through an experimental study on the basis of…

  11. Learner Views about a Distance Education Course

    ERIC Educational Resources Information Center

    Durak, Gurhan; Ataizi, Murat

    2016-01-01

    The purpose of the study was to investigate the views of learners experienced in the Distance Learning Platform (DLP), which was prepared according to an online course design model. The participants of the study were 19 learners who took the programming languages course (via the DLP for 14 weeks). Before the application, the preparation of the DLP…

  12. Self-Esteem among Adult Literacy Learners

    ERIC Educational Resources Information Center

    Lipnevich, Anastasiya; Beder, Hal

    2007-01-01

    The purpose of this study was to investigate adult literacy education learners' self-esteem and to examine the relationship between self-esteem and measures of achievement in reading and math. The rationale for the present study stemmed from the lack of research into adult literacy students' self-esteem levels. More than 200 learners enrolled in…

  13. Advanced EFL Learners' Beliefs about Pronunciation Teaching

    ERIC Educational Resources Information Center

    Alghazo, Sharif M.

    2015-01-01

    This paper explores EFL learners' beliefs about English pronunciation teaching and aims to provide insights into current teaching practices of English pronunciation at both college and university levels. To this end, the study sought to elicit the beliefs of a group of 71 third- and fourth-year EFL learners majoring in English at a university…

  14. Learner Language Analytic Methods and Pedagogical Implications

    ERIC Educational Resources Information Center

    Dyson, Bronwen

    2010-01-01

    Methods for analysing interlanguage have long aimed to capture learner language in its own right. By surveying the cognitive methods of Error Analysis, Obligatory Occasion Analysis and Frequency Analysis, this paper traces reformulations to attain this goal. The paper then focuses on Emergence Analysis, which fine-tunes learner language analysis…

  15. Identifying Successful Learners from Interaction Behaviour

    ERIC Educational Resources Information Center

    McCuaig, Judi; Baldwin, Julia

    2012-01-01

    The interaction behaviours of successful, high-achieving learners when using a Learning Management System (LMS) are different than the behaviours of learners who are having more difficulty mastering the course material. This paper explores the idea that conventional Learning Management Systems can exploit data mining techniques to predict the…

  16. Ontario's Old Growth: A Learner's Handbook.

    ERIC Educational Resources Information Center

    Stabb, Mark

    This handbook was written in response to an identified need for more public information on Ontario's old growth forests. It is meant to be taken into old growth stands, where the learner can see, touch, and study the natural ingredients of old growth forests. Much of the handbook is a guide to forest history, helping the learner to discover…

  17. A Critical Realist Orientation to Learner Needs

    ERIC Educational Resources Information Center

    Ayers, David F.

    2011-01-01

    The objective of this essay is to propose critical realism as a philosophical middle way between two sets of ontological, epistemological, and methodological assumptions regarding learner needs. Key concepts of critical realism, a tradition in the philosophy of science, are introduced and applied toward an analysis of learner needs, resulting in…

  18. Dealing with Disruptive Behavior of Adult Learners

    ERIC Educational Resources Information Center

    Dobmeier, Robert; Moran, Joseph

    2008-01-01

    The adult education literature on disruptive behavior of adult learners was reviewed and a survey on disruptive behavior of adult learners was conducted with adult educators. The findings are synthesized in a conceptual framework for understanding the types and causes of disruptive behavior, which fall into the categories of inattention,…

  19. Pairing the Adult Learner and Boutique Wineries

    ERIC Educational Resources Information Center

    Holyoke, Laura; Heath-Simpson, Delta

    2013-01-01

    This study explored connections between adult learners and their experiences in the context of small boutique wineries operating in the start-up phase of the organizational life cycle. The research objective was to gain insight regarding the pairing of adult learners with the entering of a specialty industry. Fourteen individuals from four…

  20. Vocabulary Breadth in French L2 Learners

    ERIC Educational Resources Information Center

    David, Annabelle

    2008-01-01

    Vocabulary is one of the building blocks of language and is a necessary component of learners' development. This paper aims to describe the development of the L2 lexicon from the first year of learning French as a foreign language at school to the last year of undergraduate studies at university by setting out what learners know and how this…