Science.gov

Sample records for activity learners play

  1. Learners' Interpersonal Beliefs and Generated Feedback in an Online Role-Playing Peer-Feedback Activity: An Exploratory Study

    ERIC Educational Resources Information Center

    Ching, Yu-Hui; Hsu, Yu-Chang

    2016-01-01

    Peer feedback affords interaction and critical thinking opportunities for learners in online courses. However, various factors prevent learners from taking advantage of these promising benefits. This study explored learners' perceptions of the interpersonal factors in a role-playing peer-feedback activity, and examined the types of peer feedback…

  2. Facilitating Active Learner Participation.

    ERIC Educational Resources Information Center

    Rosenberg, Steven; And Others

    1992-01-01

    Project Participate has developed and implemented a model for making decisions about interventions that enhance the ability of a preschool child with severe motor disabilities to actively participate in educational programs. The effectiveness of the process in increasing child participation in play, communication, social interaction, and mobility…

  3. Playing With Knives: The Socialization of Self-Initiated Learners.

    PubMed

    Lancy, David F

    2016-05-01

    Since Margaret Mead's field studies in the South Pacific a century ago, there has been the tacit understanding that as culture varies, so too must the socialization of children to become competent culture users and bearers. More recently, the work of anthropologists has been mined to find broader patterns that may be common to childhood across a range of societies. One improbable commonality has been the tolerance, even encouragement, of toddler behavior that is patently risky, such as playing with or attempting to use a sharp-edged tool. This laissez faire approach to socialization follows from a reliance on children as "self-initiated learners." In this article, the ethnographic literature that shows why children are encouraged to learn without prompting or guidance and how that happens is reviewed. PMID:27189394

  4. Learner Interaction in a Massively Multiplayer Online Role Playing Game (MMORPG): A Sociocultural Discourse Analysis

    ERIC Educational Resources Information Center

    Peterson, Mark

    2012-01-01

    This exploratory study investigates the linguistic and social interaction of four intermediate EFL learners during game play in a massively multiplayer online role playing game (MMORPG). Twelve illustrative episodes drawn from the participants' text chat, collected in four 70-minute sessions held over a one-month period, are analyzed from a…

  5. Supporting Sociodramatic Play in Preschools to Promote Language and Literacy Skills of English Language Learners

    ERIC Educational Resources Information Center

    Banerjee, Rashida; Alsalman, Amani; Alqafari, Shehana

    2016-01-01

    English language learners are often at risk for communication and language delays--crucial elements in the foundation of early literacy skills. Studies have shown that preschool children involved in sociodramatic play demonstrate greater proficiency and interest in language development and reading. The manuscript shares evidence-based strategies…

  6. Latino English Language Learners' Writing during Literacy-Enriched Block Play

    ERIC Educational Resources Information Center

    Snow, Marianne; Eslami, Zohreh R.; Park, Jeong Hyun

    2015-01-01

    Although growing numbers of young English language learners (ELLs) from low-income homes enroll in U.S. schools, there remains a lack of research on how they respond to common school literacy practices including a literacy-enriched play. This exploratory study aims to examine the writing behaviors of six kindergarteners in their classroom's…

  7. Exploring the Impact of Role-Playing on Peer Feedback in an Online Case-Based Learning Activity

    ERIC Educational Resources Information Center

    Ching, Yu-Hui

    2014-01-01

    This study explored the impact of role-playing on the quality of peer feedback and learners' perception of this strategy in a case-based learning activity with VoiceThread in an online course. The findings revealed potential positive impact of role-playing on learners' generation of constructive feedback as role-playing was associated…

  8. Active Gaming: The Future of Play?

    ERIC Educational Resources Information Center

    Witherspoon, Lisa; Manning, John P.

    2012-01-01

    The authors examine technology-driven games--especially active gaming--as an evolving form of children's play. They offer an overview of play and its developmental benefits, describe the literature on the emergence of technology-driven play, and reflect on the diminishment of physical play in contemporary culture. They suggest that active gaming,…

  9. Girls' Physically Active Play and Parental Behavior.

    ERIC Educational Resources Information Center

    Tauber, Margaret A.

    Sex differences in children's physical activity levels, and associations between girls' activity level, childrearing characteristics and parent-child play behavior were investigated in a quasi-naturalistic situation. As part of a longitudinal project, 144 third grade children were videotaped in a 1-hour play session with one of their parents. A…

  10. Position Statement on Active Outdoor Play

    PubMed Central

    Tremblay, Mark S.; Gray, Casey; Babcock, Shawna; Barnes, Joel; Costas Bradstreet, Christa; Carr, Dawn; Chabot, Guylaine; Choquette, Louise; Chorney, David; Collyer, Cam; Herrington, Susan; Janson, Katherine; Janssen, Ian; Larouche, Richard; Pickett, William; Power, Marlene; Sandseter, Ellen Beate Hansen; Simon, Brenda; Brussoni, Mariana

    2015-01-01

    A diverse, cross-sectorial group of partners, stakeholders and researchers, collaborated to develop an evidence-informed Position Statement on active outdoor play for children aged 3–12 years. The Position Statement was created in response to practitioner, academic, legal, insurance and public debate, dialogue and disagreement on the relative benefits and harms of active (including risky) outdoor play. The Position Statement development process was informed by two systematic reviews, a critical appraisal of the current literature and existing position statements, engagement of research experts (N = 9) and cross-sectorial individuals/organizations (N = 17), and an extensive stakeholder consultation process (N = 1908). More than 95% of the stakeholders consulted strongly agreed or somewhat agreed with the Position Statement; 14/17 participating individuals/organizations endorsed it; and over 1000 additional individuals and organizations requested their name be listed as a supporter. The final Position Statement on Active Outdoor Play states: “Access to active play in nature and outdoors—with its risks— is essential for healthy child development. We recommend increasing children’s opportunities for self-directed play outdoors in all settings—at home, at school, in child care, the community and nature.” The full Position Statement provides context for the statement, evidence supporting it, and a series of recommendations to increase active outdoor play opportunities to promote healthy child development. PMID:26062040

  11. Position Statement on Active Outdoor Play.

    PubMed

    Tremblay, Mark S; Gray, Casey; Babcock, Shawna; Barnes, Joel; Bradstreet, Christa Costas; Carr, Dawn; Chabot, Guylaine; Choquette, Louise; Chorney, David; Collyer, Cam; Herrington, Susan; Janson, Katherine; Janssen, Ian; Larouche, Richard; Pickett, William; Power, Marlene; Sandseter, Ellen Beate Hansen; Simon, Brenda; Brussoni, Mariana

    2015-06-01

    A diverse, cross-sectorial group of partners, stakeholders and researchers, collaborated to develop an evidence-informed Position Statement on active outdoor play for children aged 3-12 years. The Position Statement was created in response to practitioner, academic, legal, insurance and public debate, dialogue and disagreement on the relative benefits and harms of active (including risky) outdoor play. The Position Statement development process was informed by two systematic reviews, a critical appraisal of the current literature and existing position statements, engagement of research experts (N=9) and cross-sectorial individuals/organizations (N=17), and an extensive stakeholder consultation process (N=1908). More than 95% of the stakeholders consulted strongly agreed or somewhat agreed with the Position Statement; 14/17 participating individuals/organizations endorsed it; and over 1000 additional individuals and organizations requested their name be listed as a supporter. The final Position Statement on Active Outdoor Play states: "Access to active play in nature and outdoors--with its risks--is essential for healthy child development. We recommend increasing children's opportunities for self-directed play outdoors in all settings--at home, at school, in child care, the community and nature." The full Position Statement provides context for the statement, evidence supporting it, and a series of recommendations to increase active outdoor play opportunities to promote healthy child development. PMID:26062040

  12. A Development of Game-Based Learning Environment to Activate Interaction among Learners

    NASA Astrophysics Data System (ADS)

    Takaoka, Ryo; Shimokawa, Masayuki; Okamoto, Toshio

    Many studies and systems that incorporate elements such as “pleasure” and “fun” in the game to improve a learner's motivation have been developed in the field of learning environments. However, few are the studies of situations where many learners gather at a single computer and participate in a game-based learning environment (GBLE), and where the GBLE designs the learning process by controlling the interactions between learners such as competition, collaboration, and learning by teaching. Therefore, the purpose of this study is to propose a framework of educational control that induces and activates interaction between learners intentionally to create a learning opportunity that is based on the knowledge understanding model of each learner. In this paper, we explain the design philosophy and the framework of our GBLE called “Who becomes the king in the country of mathematics?” from a game viewpoint and describe the method of learning support control in the learning environment. In addition, we report the results of the learning experiment with our GBLE, which we carried out in a junior high school, and include some comments by a principal and a teacher. From the results of the experiment and some comments, we noticed that a game may play a significant role in weakening the learning relationship among students and creating new relationships in the world of the game. Furthermore, we discovered that learning support control of the GBLE has led to activation of the interaction between learners to some extent.

  13. Naturalistic Observations of Children's Activities and Roles While Playing with Their Siblings and Friends.

    ERIC Educational Resources Information Center

    Stoneman, Zolinda; And Others

    1984-01-01

    Reports studies of children's interactions at home with younger siblings and/or best friends. Finds gender and group composition differences in the play activities selected, amount of positive and negative interaction, and assumption of the roles of teacher/learner, manager/manager and playmate. (CB)

  14. Active Play Opportunities at Child Care

    PubMed Central

    Saelens, Brian E.; Christakis, Dimitri A.

    2015-01-01

    BACKGROUND AND OBJECTIVES: Physical activity (PA) is important for children’s health and development, yet preschoolers are not meeting PA recommendations. The objective of this study was to examine different PA opportunities at child care and how variation in indoor versus outdoor and free versus teacher-led opportunities relate to children’s PA. METHODS: An observational study of 98 children (mean age 4.5 years, 49% girls) from 10 child care centers. Classrooms were observed for at least 4 full days per center (total 50 days) to categorize time into (1) not an active play opportunity (APO); (2) naptime; (3) APO, outdoor free play; (4) APO, outdoor teacher-led; (5) APO, indoor free play; and (6) APO, indoor teacher-led. Children wore accelerometers during observations. Linear regression models examined the influence of APO categories on moderate-vigorous physical activity (MVPA) and sedentary time. RESULTS: Children’s activity was 73% sedentary, 13% light, and 14% MVPA. For 88% of time children did not have APOs, including 26% time as naptime. On average, 48 minutes per day were APOs (41% sedentary, 18% light, and 41% MVPA), 33 minutes per day were outdoors. The most frequent APO was outdoor free play (8% of time); outdoor teacher-led time was <1%. Children were more active and less sedentary outdoors versus indoors and during the child-initiated APOs (indoors and outdoors) versus teacher-led APOs. CONCLUSIONS: Preschoolers were presented with significantly fewer than recommended opportunities for PA at child care. More APOs are needed for children to meet recommendations, particularly those that encourage more outdoor time, more teacher-led and child-initiated active play, and flexibility in naptime for preschoolers. PMID:25986016

  15. World History Plays, Puzzles and Activities.

    ERIC Educational Resources Information Center

    Stevens, Lawrence

    This instructional resource, for grades 7-10, includes a collection of 10 plays with related learning activities. Units of study include: (1) "Alexander the Great and the Greeks"; (2) "The Black Death and the End of the Middle Ages"; (3) "Robert Clive and Imperialism"; (4) "Christopher Columbus and the Age of Exploration"; (5) "Fall of the…

  16. Language Learning Activities of Distance EFL Learners in the Turkish Open Education System as the Indicator of Their Learner Autonomy

    ERIC Educational Resources Information Center

    Altunay, Dilek

    2013-01-01

    This study investigates the noncompulsory language learning activities performed by a group of distance EFL learners in the Turkish Open Education System. Performance of these activities has been considered as an indicator of their learner autonomy. The data were collected through an online questionnaire and interviews. The study shows that in…

  17. Interactions between and among Heritage Language Learners and Second Language Learners during Collaborative Writing Activities: How Learners Attend to Language

    ERIC Educational Resources Information Center

    Walls, Laura

    2013-01-01

    This study investigates the dynamics in the Spanish classroom between heritage language learner (HLL) dyads, second language learner (L2L) dyads, and mixed HLL-L2L dyads. Specifically, it examines oral, written and embodied discourse that informs our understanding of how learners attend to language. Analysis for this dissertation examined…

  18. Playing with Heutagogy: Exploring Strategies to Empower Mature Learners in Higher Education

    ERIC Educational Resources Information Center

    Canning, Natalie

    2010-01-01

    Mature learners often invest a great deal of emotional energy in starting a higher education qualification. They have complex needs which are often less to do with their ability to learn and more to do with aspects of confidence and levels of self-belief about achieving or feeling "good enough" to participate. This article explores the…

  19. Plays Well with Others: A Study of EFL Learner Reciprocity in Action

    ERIC Educational Resources Information Center

    Ozkose-Biyik, Cagri; Meskill, Carla

    2015-01-01

    Classroom observation studies suggest that the teacher-calculus is complex and sensitive to learner behaviors. In language education, this becomes particularly important due to strong emphasis on productive interpersonal interaction. This study set out to understand what constitutes positive learning behaviors in an EFL context. The construct of…

  20. Teaching Students to Be Active Learners; The Principal's Role.

    ERIC Educational Resources Information Center

    Nelson-Nasca, Donald

    1993-01-01

    Learning is not a spectator sport but requires active learners who integrate new experiences into existing cognitive structures. Principals can help students develop self-responsibility by initiating discussions on this topic, identifying and sharing multiple learning resources for student use, and modeling uses of assignments based on mastery…

  1. Does Translation Contribute to Learners' Free Active Vocabulary?

    ERIC Educational Resources Information Center

    Asiyaban, Amir R.; Bagheri, Mohammad S.

    2012-01-01

    This research was conducted to find out whether or not using "translation" technique in vocabulary teaching would have any positive effects on the "free active" vocabulary of Iranian learners of English. To carry out the research, eighty-eight intermediate male and female students were chosen. The participants were divided into four "male…

  2. Creating Active Learners on Hawaiian Adventures through Project ALOHA.

    ERIC Educational Resources Information Center

    Sato, Claire; Anderson, Thomas; Sakuda, Katherine

    1998-01-01

    Describes an integrated curriculum project for fourth graders in a Hawaiian elementary school with a highly transient population. The project, ALOHA (Active Learners on Hawaiian Adventures) was developed to motivate students in learning about Hawaii's culture and ecosystems. Cooperation between the library media specialist, technology coordinator,…

  3. Methods for Evaluating Learner Activities with New Technologies: Guidelines for the Lab@Future Project

    ERIC Educational Resources Information Center

    Mwanza-Simwami, Daisy; Engestrom, Yrjo; Amon, Tomaz

    2009-01-01

    The task of evaluating learner activities with new technologies is becoming increasingly complex because traditional evaluation strategies do not adequately consider the unique and often dynamic characteristics of learners and activities carried out. Learner activities are largely driven by motives and relationships that exist in the context in…

  4. Acquisition of Mathematical Language: Suggestions and Activities for English Language Learners

    ERIC Educational Resources Information Center

    Cirillo, Michelle; Bruna, Katherine Richardson; Herbel-Eisenmann, Beth

    2010-01-01

    In this article, we describe aspects of mathematical language that could be problematic to English-language learners, provide recommendations for teaching English-language learners, and suggest activities intended to foster language development in mathematics. (Contains 1 figure.)

  5. Immediate and Ultimate Functions of Physical Activity Play.

    ERIC Educational Resources Information Center

    McCune, Lorraine

    1998-01-01

    Play has been difficult to define because it is an aspect of many activities rather than of just a specific kind of activity. Classic theorists such as Piaget and Vygotsky emphasized representational play as play in its purist form, but both immediate and ultimate functions of play can be discerned in simple physical activity play. (Author)

  6. Play.

    ERIC Educational Resources Information Center

    Rogers, Fred; Sharapan, Hedda

    1993-01-01

    Contends that, in childhood, work and play seem to come together. Says that for young children their play is their work, and the more adults encourage children to play, the more they emphasize important lifelong resource. Examines some uses of children's play, making and building, artwork, dramatic play, monsters and superheroes, gun play, and…

  7. Learning To Play, Playing To Learn. Games and Activities To Teach Sharing, Caring, and Compromise.

    ERIC Educational Resources Information Center

    Steffens, Charlie; Gorin, Spencer

    This book demonstrates that therapeutic play can provide a solution to contemporary socialization problems. It provides a selection of games and activities that teach children about living in the world through the dynamics of play. Section 1, "Introduction," defines "play" and the philosophy and rules behind a healthy play program. Section 2,…

  8. Discovering Me: Music Activities for Special Learners.

    ERIC Educational Resources Information Center

    Thompson, Keith P.; And Others

    The book contains information on musical activities which were field tested in Project PASE (Program in the Arts for Special Education, Pennsylvania) classrooms with a wide range of exceptionalities from preschool age to adolescence. Activities are seen to help children become more aware of their bodies, feelings, and themselves; feel important…

  9. Learners' Perceptions of Instructional Design Practice in a Situated Learning Activity

    ERIC Educational Resources Information Center

    Woolf, Nicholas; Quinn, James

    2009-01-01

    This case study investigated learners' perceptions of value from participating in a learning activity designed to model professional instructional design practice. Learners developed instructional design products for a corporate client in the context of a classroom-based course. The findings indicate that learners perceived different kinds of…

  10. E-learning Constructive Role Plays for EFL Learners in China's Tertiary Education

    ERIC Educational Resources Information Center

    Shen, Lin; Suwanthep, Jitpanat

    2011-01-01

    Recently, speaking has played an increasingly important role in second/foreign language settings. However, in many Chinese universities, EFL students rarely communicate in English with other people effectively. The existing behavioristic role plays on New Horizon College English (NHCE) e-learning do not function successfully in supplementing EFL…

  11. Supporting Emergent Literacy in Play-based Activities.

    ERIC Educational Resources Information Center

    Hanline, Mary Frances

    2001-01-01

    This article presents ideas for using play activities to support the development of emergent literacy skills in young children, including those with disabilities. Four principles of promoting early literacy skills are explained and applied to activities in block and microsymbolic play, macrosymbolic play, and fluid construction play. The…

  12. Microblogging Activities: Language Play and Tool Transformation

    ERIC Educational Resources Information Center

    Hattem, David

    2014-01-01

    The following is a qualitative case study presenting three vignettes exploring the use of language play while microblogging during an academically sanctioned task. Ten students and one teacher used "Twitter" in an intensive, English as a second language advanced grammar course to practice writing sentences with complex grammatical…

  13. Playing It Smart: Safety in Extracurricular Activities

    ERIC Educational Resources Information Center

    Armenta, Tony

    2011-01-01

    An integral part of the school experience for many students is involvement in extracurricular activities such as athletics, cheerleading, band, and others. Likewise, cocurricular activities, such as field trips, provide a chance for students to connect off-campus experiences to the material learned in the classroom. These types of activities,…

  14. The effect of curricular activities on learner autonomy: the perspective of undergraduate mechanical engineering students

    NASA Astrophysics Data System (ADS)

    Duarte, M.; Leite, C.; Mouraz, A.

    2016-01-01

    This study researches how first-year engineering students perceived the influence of curricular activities on their own learning autonomy, measured with an adaptation of the Personal Responsibility Orientation to Self-direction in Learning Scale (PRO-SDLS). Participants were questioned to assess the influence of the teacher's role. The results indicate that learners' characteristics (motivation and self-efficacy) contribute more to learner autonomy (LA) than the teaching-learning transaction (control and initiative), as in the original PRO-SDLS validation. The most autonomous learners presented higher values in all LA components and dimensions, but the differences were greater in motivation and initiative. The participants with higher LA were not as dependent on the teacher, regarding assessment, the completion of classroom tasks and deadlines. Regardless of the degree of autonomy in learning, all participants viewed teachers as the main source of information. Therefore, LA plays an important role in teaching activities planning. Suggestions for adjustments and more flexible learning scenarios are formulated.

  15. Does Active Learning Enhance Learner Outcomes? Evidence from Discussion Participation in Online Classes

    ERIC Educational Resources Information Center

    Wilson, Bruce M.; Pollock, Philip H.; Hamann, Kerstin

    2007-01-01

    Discussion is one form of active learning, which has been linked to better learner outcomes. Little is known about the relationship between active learning through discussion and learner outcome in the online environment. Here, we construct an index of active learning online that includes the number of postings a student has read, the number of…

  16. Learners' Evaluations of Teacher-Fronted and Student-Centred Classroom Activities.

    ERIC Educational Resources Information Center

    Garrett, Peter; Shortall, Terry

    2002-01-01

    Investigates language learners beliefs about their experiences with different types of classroom activities, specifically teacher-fronted activities and student-centered pairwork activities. Discusses the usefulness of studying learners' beliefs about their learning experiences, their perceptions of affective and learning outcomes from these…

  17. Transition Problems and Play as Transitory Activity

    ERIC Educational Resources Information Center

    Brostrom, Stig

    2005-01-01

    Because too many children experience the transition to school as a culture shock, during the past decade teachers have implemented so-called transition activities in order to bridge the gap between preschool and school. However, transition to school also calls for a development of higher mental functions, among others the development of children's…

  18. Pay for Play: Fees for Cocurricular Activities.

    ERIC Educational Resources Information Center

    Pepe, Thomas J.; Tufts, Alice L.

    1984-01-01

    As school budgets face serious problems, one area under examination is the cocurricular activities section of the school budget. Many districts are charging user fees to students participating in school sports, band, drama, and even elective courses. Since no direct reference is made to education in the United States Constitution, education is a…

  19. Play

    NASA Astrophysics Data System (ADS)

    Harteveld, Casper

    Designing a game with a serious purpose involves considering the worlds of Reality and Meaning yet it is undeniably impossible to create a game without a third world, one that is specifically concerned with what makes a game a game: the play elements. This third world, the world of people like designers and artists, and disciplines as computer science and game design, I call the world of Play and this level is devoted to it. The level starts off with some of the misperceptions people have of play. Unlike some may think, we play all the time, even when we grow old—this was also very noticeable in designing the game Levee Patroller as the team exhibited very playful behavior at many occasions. From there, I go into the aspects that characterize this world. The first concerns the goal of the game. This relates to the objectives people have to achieve within the game. This is constituted by the second aspect: the gameplay. Taking actions and facing challenges is subsequently constituted by a gameworld, which concerns the third aspect. And all of it is not possible without the fourth and final aspect, the type of technology that creates and facilitates the game. The four aspects together make up a “game concept” and from this world such a concept can be judged on the basis of three closely interrelated criteria: engagement, immersion, and fun.

  20. Fourth-Grade Emergent Bilingual Learners' Scientific Reasoning Complexity, Controlled Experiment Practices, and Content Knowledge When Discussing School, Home, and Play Contexts

    ERIC Educational Resources Information Center

    Buxton, Cory A.; Salinas, Ale; Mahotiere, Margarette; Lee, Okhee; Secada, Walter G.

    2015-01-01

    Background: In exploring how emergent bilingual learners' prior knowledge from home and play contexts might influence their scientific reasoning, this study drew upon two distinct research traditions: (a) experimental research from the developmental and cognitive psychology tradition, and (b) research on culturally and linguistically diverse…

  1. The Need for Play & Play-Like Activities in the Junior Classroom.

    ERIC Educational Resources Information Center

    Silver, Allan

    1992-01-01

    Draws from personal experiences in teaching a fourth-grade class in Canada to highlight the benefits for students of incorporating into the curriculum such playlike activities as shaping plasticine models, painting, cutting and pasting, and playing games. Identifies skills reinforced by particular activities and the benefits of the activities to…

  2. How Do Distance Learners Use Activities in Self-Instructional Materials?

    ERIC Educational Resources Information Center

    Mishra, Sanjaya; Gaba, Ashok Kumar

    2001-01-01

    Presents results of a study on the use of learning activities in self-instructional materials by distance learners of the Indira Gandhi National Open University (IGNOU). It shows that learners make use of the activities extensively as they have positive perceptions about benefits of Self-Assessment Questions and Terminal Questions given in the…

  3. The Child as an Active Learner: Views, Practices, and Barriers in Chinese Early Childhood Education

    ERIC Educational Resources Information Center

    Tang, Fengling

    2006-01-01

    The Chinese view of the child is in the process of changing from the dependent child of traditional Chinese society to the child as an active learner in contemporary China. The view of the child as an active learner forces early childhood practitioners to rethink the features of the child's learning and development, individuality, and needs and…

  4. Faithful Imitator, Legitimate Speaker, Playful Creator and Dialogical Communicator: Shift in English Learners' Identity Prototypes

    ERIC Educational Resources Information Center

    Gao, Yihong

    2014-01-01

    This paper attempts to conceptualize identity prototypes regarding model L2 learners/users of English over the past 50 years, as embedded in research discourses. For a long time, the ideal learner was a "faithful imitator" whose L2 use and cultural conduct were strictly modeled on the native speaker (NS). With postcolonial changes around…

  5. A Comparative Study of Active Play on Differently Designed Playgrounds

    ERIC Educational Resources Information Center

    Luchs, Antje; Fikus, Monika

    2013-01-01

    The physical and social environment of children in cities is continuously changing. Knowledge about the positive effects of natural play experiences within the child's development is becoming widely known. Affordances of diverse landscape elements and especially loose parts for play in natural environments influence play activities. New…

  6. Children's Physical Activity: The Contribution of Playing and Walking

    ERIC Educational Resources Information Center

    Mackett, Roger L.; Paskins, James

    2008-01-01

    This paper draws on research in which 200 children were fitted with motion sensors and asked to keep travel and activity diaries. The findings show that walking and playing away from home can contribute significantly to children's volume of physical activity, with consequent implications for their health. Not only do both playing and walking…

  7. Investigating Learner Attitudes toward E-Books as Learning Tools: Based on the Activity Theory Approach

    ERIC Educational Resources Information Center

    Liaw, Shu-Sheng; Huang, Hsiu-Mei

    2016-01-01

    This paper investigates the use of e-books as learning tools in terms of learner satisfaction, usefulness, behavioral intention, and learning effectiveness. Based on the activity theory approach, this research develops a research model to understand learner attitudes toward e-books in two physical sizes: 10? and 7?. Results suggest that screen…

  8. Transformational Processes and Learner Outcomes for Online Learning: An Activity Theory Case Study of Spanish Students

    ERIC Educational Resources Information Center

    Terantino, Joseph M.

    2009-01-01

    The purpose of this exploratory study was to examine the actions of online language learners from an activity theoretical perspective. It also attempted to explain how the students' learning outcomes evolved from their online learning experiences. This explanation placed an emphasis on the learners' previous experiences, defining their activity…

  9. Training Learners to Use Quizlet Vocabulary Activities on Mobile Phones in Vietnam with Facebook

    ERIC Educational Resources Information Center

    Tran, Phuong

    2016-01-01

    Mobile phone ownership among university students in Vietnam has reached almost 100%, exceeding that of Internet-capable desktop computers. This has made them increasingly popular to allow learners to carry out learning activities outside of the classroom, but some studies have suggested that learners are not always willing to engage in activities…

  10. Beginning Learners' Development of Interactional Competence: Alignment Activity

    ERIC Educational Resources Information Center

    Tecedor, Marta

    2016-01-01

    This study examined the development of interactional competence (Hall, 1993; He & Young, 1998) by beginning learners of Spanish as indexed by their use of alignment moves. Discourse analysis techniques and quantitative data analysis were used to explore how 52 learners expressed alignment and changes in participation patterns in two sets of…

  11. Older Adult Learners: A Comparison of Active and Non-Active Learners

    ERIC Educational Resources Information Center

    Sloane-Seale, Atlanta; Kops, Bill

    2007-01-01

    This paper reports on a 2004 follow-up study conducted in partnership with the University of Manitoba Continuing Education Division and local senior's organizations. The partnership was formed in 2002-03 to promote applied research on lifelong learning and older adults, develop new and complement existing educational activities, and explore new…

  12. Playing the Classroom-as-Game: Building a Community of Learners at the Start of a New Year

    ERIC Educational Resources Information Center

    Carlson, David Lee

    2008-01-01

    The author, a teacher educator, likens taking an English class to playing a game, and by taking the metaphor seriously, he develops an innovative and engaging way to start off the school year. This article describes the classroom-as-game activity that he used during the first week of school. Using the concept of a game as metaphor for the…

  13. Superhero Toys and Boys' Physically Active and Imaginative Play

    ERIC Educational Resources Information Center

    Parsons, Amy; Howe, Nina

    2006-01-01

    The influence of superhero versus nonsuperhero toys on boys' physically active and imaginative play was studied in 29 dyads (n = 58 middle-class preschool boys; M age = 54.95 mos, SD = 5.28 mos). Each dyad participated in two play sessions: 1) superhero toys (media related) and 2) nonsuperhero (nonmedia related) toys. Dyads were observed for the…

  14. CHILDREN'S MOVEMENT SKILLS WHEN PLAYING ACTIVE VIDEO GAMES.

    PubMed

    Hulteen, Ryan M; Johnson, Tara M; Ridgers, Nicola D; Mellecker, Robin R; Barnett, Lisa M

    2015-12-01

    Active video games (AVGs) may be useful for movement skill practice. This study examined children's skill execution while playing Xbox Kinect™ and during movement skill assessment. Nineteen children (10 boys, 9 girls; M age=7.9 yr., SD=1.4) had their skills assessed before AVG play and then were observed once a week for 6 wk. while playing AVGs for 50 min. While AVG play showed evidence of correct skill performance (at least 30-50% of the time when playing table tennis, tennis, and baseball), nearly all skills were more correctly performed during skill assessment (generally more than 50% of the time). This study may help researchers to better understand the role AVGs could play in enhancing real life movement skills. PMID:26654991

  15. Engagement, enjoyment, and energy expenditure during active video game play

    PubMed Central

    Lyons, Elizabeth J.; Tate, Deborah F.; Ward, Dianne S.; Ribisl, Kurt M.; Bowling, J. Michael; Kalyanaraman, Sriram

    2014-01-01

    Objective Playing active video games can produce moderate levels of physical activity, but little is known about how these games motivate players to be active. Several psychological predictors, such as perceptions of competence, control, and engagement, may be associated with enjoyment of a game, which has in turn been hypothesized to predict energy expended during play. However, these relationships have yet to be tested in active video games. Methods Young adults aged 18–35 (N = 97, 50 female) < 300 pounds played a Dance Dance Revolution game for 13 minutes while energy expenditure was measured using indirect calorimetry. Self-reported measures of engagement, perceived competence, perceived control, and enjoyment were taken immediately afterwards. Mediation was analyzed using path analysis. Results A path model in which enjoyment mediated the effects of engagement, perceived competence, and perceived control on energy expenditure and BMI directly affected energy expenditure was an adequate fit to the data, χ2(1, N = 97) = .199, p = .655; CFI = 1.00; RMSEA < .001; 90% CI = .000 - .206; p = .692. Enjoyment mediated the relationship between engagement and energy expenditure (indirect effect = .138, p = .028), but other mediated effects were not significant. Conclusion Engagement, enjoyment, and BMI affect energy expended during active video game play. Games that are more enjoyable and engaging may produce greater intensity activity. Developers, practitioners, and researchers should consider characteristics that influence these predictors when creating or recommending active video games. PMID:23527520

  16. Active Ageing and Universities: Engaging Older Learners. Research Report

    ERIC Educational Resources Information Center

    Phillipson, Chris; Ogg, Jim

    2010-01-01

    This report reviews the engagement of older learners (defined as those aged 50 and over) in education and training with particular reference to their involvement in higher education. The ageing of populations was one of the most important trends in the 20th century and will raise major challenges in this century. Appended are: (1) Selected UK…

  17. Influence of playing wind instruments on activity of masticatory muscles.

    PubMed

    Gotouda, A; Yamaguchi, T; Okada, K; Matsuki, T; Gotouda, S; Inoue, N

    2007-09-01

    The aim of this study was to elucidate the influence of change in sound tone of playing wind instruments on activity of jaw-closing muscles and the effect of sustained playing for a long time on fatigue of jaw-closing muscles. Electromyograms (EMG) of 19 brass instrument players and 14 woodwind instrument players were measured while playing instruments in tuning tone and high tone and under other conditions. Nine brass instrument players and nine woodwind instrument players played instruments for 90 min. Before and after the exercise, power spectral analyses of EMG from masseter muscles at 50% of maximum voluntary clenching level were performed and mean power frequency (MPF) were calculated. Root mean square (RMS) of EMG in masseter and temporal muscles while playing were slightly larger than those at rest but extremely small in comparison with those during maximum clenching. Root mean square in orbicularis oris and digastric muscles were relatively large when playing instruments. In the brass instrument group, RMS in high tone was significantly higher than that in tuning tone in all muscles examined. In the woodwind instrument group, RMS in high tone was not significantly higher than that in tuning tone in those muscles. Mean power frequency was not decreased after sustained playing in both instrument groups. These findings indicate that contractive load to jaw-closing muscles when playing a wind instrument in both medium and high tone is very small and playing an instrument for a long time does not obviously induce fatigue of jaw-closing muscles. PMID:17716263

  18. Should Our Students Pay to Play Extracurricular Activities?

    ERIC Educational Resources Information Center

    Hoff, Dianne L.; Mitchell, Sidney N.

    2007-01-01

    This article talks about the "Pay-to-play" issue in some districts. State constitutions across the nation include guarantees of "free public education." Simply put, that means that school programs may not charge fees for participation. In this article, the authors examine the issue on whether extracurricular activities are integral parts of the…

  19. Gross Activity of Children at Play. (Internal Report).

    ERIC Educational Resources Information Center

    Wuellner, Lance

    Time-lapse photography was used to record the gross play activity of preschool children, rated according to three measures of equipment use and three measures of movement. The definition and derivation of these measures was outlined, and five hypotheses were presented and tested concerning the variability and interrelation of the measures.…

  20. Physical Activity Pattern of Malaysian Preschoolers: Environment, Barriers, and Motivators for Active Play.

    PubMed

    Lee, Shoo Thien; Wong, Jyh Eiin; Ong, Wei Wen; Ismail, Mohd Noor; Deurenberg, Paul; Poh, Bee Koon

    2016-07-01

    Children's physical activity has been correlated with child characteristics and social or physical environment. This study aimed to compare preschoolers' physical activity among various sociodemographic characteristics and to determine barriers, motivators, and environmental factors for active play. A total of 835 preschoolers were included in this analysis. Time spent on active play, quiet play, and screen time was reported by parents. Boys spent significantly more time on active play and screen time than girls. Time spent on quiet play was highest in East Coast Peninsular Malaysia and lowest in Sarawak. Some 40% of children achieved active play recommendation while 27% exceeded daily screen time recommendation. Most parents reported that their child played actively in the house area; and that the main barrier and motivator to active play were safety and child's enjoyment, respectively. These findings demonstrate that sociodemographic characteristics and environment should be considered in designing physical activity intervention programs. PMID:27026634

  1. Energy expended by boys playing active video games.

    PubMed

    White, Kate; Schofield, Grant; Kilding, Andrew E

    2011-03-01

    The purpose of this study was to: (1) determine energy expenditure (EE) during a range of active video games (AVGs) and (2) determine whether EE during AVGs is influenced by gaming experience or fitness. Twenty-six boys (11.4±0.8 years) participated and performed a range of sedentary activities (resting, watching television and sedentary gaming), playing AVGs (Nintendo® Wii Bowling, Boxing, Tennis, and Wii Fit Skiing and Step), walking and running including a maximal fitness test. During all activities, oxygen uptake, heart rate and EE were determined. The AVGs resulted in a significantly higher EE compared to rest (63-190%, p≤0.001) and sedentary screen-time activities (56-184%, p≤0.001). No significant differences in EE were found between the most active video games and walking. There was no evidence to suggest that gaming experience or aerobic fitness influenced EE when playing AVGs. In conclusion, boys expended more energy during active gaming compared to sedentary activities. Whilst EE during AVG is game-specific, AVGs are not intense enough to contribute towards the 60min of daily moderate-to-vigorous physical activity that is currently recommended for children. PMID:20810313

  2. What Does Metalinguistic Activity in Learners' Interaction during a Collaborative L2 Writing Task Look Like?

    ERIC Educational Resources Information Center

    Gutierrez, Xavier

    2008-01-01

    This article examines the metalinguistic activity that arose in the interaction of 7 groups of bilingual learners writing collaboratively in their second language (L2), English. A microanalysis of this interaction reveals that metalinguistic activity comprises 3 types of oral production: comments, speech actions, and text reformulations. Text…

  3. Discussion Activities To Increase Intercultural Communication Skills for Japanese Learners in EFL.

    ERIC Educational Resources Information Center

    Kresovich, Brant M.

    1988-01-01

    The study describes ten discussion activities designed to improve the communicative abilities of Japanese learners of English based on cultural instruction goals. The activities target intermediate and advanced students, but teachers can modify the lessons for false beginners. All exercises stress speaking and listening. They focus on topics…

  4. Learner-Centered Activities from the DVD-Format "Crouching Tiger, Hidden Dragon."

    ERIC Educational Resources Information Center

    Lin, Li-Yun

    This paper demonstrates how Taiwanese English-as-a-Second-Language (ESL) college teachers and students collaborate and negotiate to design various learner-centered activities based on the Chinese film, "Crouching Tiger, Hidden Dragon." These activities are intended to enhance students' listening and speaking abilities. The paper demonstrates eight…

  5. Playing by Programming: Making Gameplay a Programming Activity

    ERIC Educational Resources Information Center

    Weintrop, David; Wilensky, Uri

    2016-01-01

    Video games are an oft-cited reason for young learners getting interested in programming and computer science. As such, many learning opportunities build on this interest by having kids program their own video games. This approach, while sometimes successful, has its drawbacks stemming from the fact that the challenge of programming and game…

  6. Running activity profile of adolescent tennis players during match play.

    PubMed

    Hoppe, Matthias W; Baumgart, Christian; Bornefeld, Jutta; Sperlich, Billy; Freiwald, Jürgen; Holmberg, Hans-Christer

    2014-08-01

    The aims of this study were (1) to assess the running activities of adolescent tennis players during match play with respect to velocity, acceleration, and deceleration; (2) to characterize changes in these activities during the course of a match; and (3) to identify potential differences between winners and losers. Twenty well-trained adolescent male athletes (13 ± 1 y) played one simulated match each (giving a total of 10 matches), during which distances covered at different velocity categories (0 to < 1, 1 to < 2, 2 to < 3, 3 to < 4, and ≥ 4 m·s(-1)) and number of running activities involving high velocity (≥ 3 m·s(-1)), acceleration (≥ 2 m·s(-2)), and deceleration (≤ -2 m·s(-2)) were monitored using a global positioning system (10 Hz). Heart rate was also assessed. The total match time, total distance covered, peak velocity, and mean heart rate were 81.2 ± 14.6 min, 3362 ± 869 m, 4.4 ± 0.8 m·s(-1), and 159 ± 12 beats·min(-1), respectively. Running activities involving high acceleration (0.6 ± 0.2 n·min(-1)) or deceleration (0.6 ± 0.2 n·min(-1)) were three times as frequent as those involving high velocity (0.2 ± 0.1 n·min(-1)). No change in the pattern of running activities (P ≥ .13, d ≤ 0.39) and no differences between winners and losers (P ≥ .22, d ≤ 0.53) were evident during match play. We conclude that training of well-trained adolescent male tennis players need not focus on further development of their running abilities, since this physical component of multifactorial tennis performance does not change during the course of a match and does not differ between the winners and losers. PMID:25111161

  7. 78 FR 11965 - Agency Information Collection (Learner's Perception (LP) Survey) Activities Under OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-20

    ... AFFAIRS Agency Information Collection (Learner's Perception (LP) Survey) Activities Under OMB Review...'s Perception (LP) Survey, VA Form 10-0439. OMB Control Number: 2900-0691. Type of Review: Extension... trainees perception of their clinical experience with VA versus non-VA facilities. VA will use the data...

  8. Flipping the Classroom for English Language Learners to Foster Active Learning

    ERIC Educational Resources Information Center

    Hung, Hsiu-Ting

    2015-01-01

    This paper describes a structured attempt to integrate flip teaching into language classrooms using a WebQuest active learning strategy. The purpose of this study is to examine the possible impacts of flipping the classroom on English language learners' academic performance, learning attitudes, and participation levels. Adopting a…

  9. Active Learning for Discovery and Innovation in Criminology with Chinese Learners

    ERIC Educational Resources Information Center

    Li, Jessica C. M.; Wu, Joseph

    2015-01-01

    Whereas a great deal of literature based upon the context of Western societies has concluded criminology is an ideal discipline for active learning approach, it remains uncertain if this learning approach is applicable to Chinese learners in the discipline of criminology. This article describes and provides evidence of the benefits of using active…

  10. An Emergent Language Program Framework: Actively Involving Learners in Needs Analysis.

    ERIC Educational Resources Information Center

    Savage, William; Storer, Graeme

    1992-01-01

    Relates the experience of the staff of an aquaculture outreach program in Northeast Thailand in implementing an English for special purposes program. By actively involving learners in both the needs analysis and program design, teachers were able to adapt the program content to the requirements of the students. (15 references) (JL)

  11. Synthesizing Technology Adoption and Learners' Approaches towards Active Learning in Higher Education

    ERIC Educational Resources Information Center

    Chan, Kevin; Cheung, George; Wan, Kelvin; Brown, Ian; Luk, Green

    2015-01-01

    In understanding how active and blended learning approaches with learning technologies engagement in undergraduate education, current research models tend to undermine the effect of learners' variations, particularly regarding their styles and approaches to learning, on intention and use of learning technologies. This study contributes to further…

  12. A "Dialogic" Approach to the Design of a Transcultural Communication Classroom Activity for Multilingual Learners

    ERIC Educational Resources Information Center

    Thompson, Celia Helen

    2011-01-01

    When preparing teaching materials about communication between people from different linguistic backgrounds, many factors require consideration; these include theoretical orientation, purpose, context, educational needs, study level, as well as the cultural backgrounds of the teachers and their target learners. The classroom activity described in…

  13. Fashion Design: Designing a Learner-Active, Multi-Level High School Course

    ERIC Educational Resources Information Center

    Nelson, Diane

    2009-01-01

    A high school fashion design teacher has much in common with the ringmaster of a three-ring circus. The challenges of teaching a hands-on course are to facilitate the entire class and to meet the needs of individual students. When teaching family and consumer sciences, the goal is to have a learner-active classroom. Revamping the high school's…

  14. Cross-Language Activation in Children's Speech Production: Evidence from Second Language Learners, Bilinguals, and Trilinguals

    ERIC Educational Resources Information Center

    Poarch, Gregory J.; van Hell, Janet G.

    2012-01-01

    In five experiments, we examined cross-language activation during speech production in various groups of bilinguals and trilinguals who differed in nonnative language proficiency, language learning background, and age. In Experiments 1, 2, 3, and 5, German 5- to 8-year-old second language learners of English, German-English bilinguals,…

  15. Investigating the Use of Inquiry & Web-Based Activities with Inclusive Biology Learners

    ERIC Educational Resources Information Center

    Bodzin, Alec M.; Waller, Patricia L.; Edwards, Lana; Darlene Kale, Santoro

    2007-01-01

    A Web-integrated biology program is used to explore how to best assist inclusive high school students to learn biology with inquiry-based activities. Classroom adaptations and instructional strategies teachers may use to assist in promoting biology learning with inclusive learners are discussed.

  16. Hepatic ERK activity plays a role in energy metabolism.

    PubMed

    Jiao, Ping; Feng, Bin; Li, Yujie; He, Qin; Xu, Haiyan

    2013-08-15

    Mitogen activated protein kinases (MAPKs), such as c-Jun N-terminal kinase (JNK) and P38, have been reported to play important roles in energy homeostasis. In this study, we show that the activity of extracellular signal-regulated kinase (ERK) is increased in the livers of diet induced and genetically obese mice. Activation of ERK in the livers of lean mice by over-expressing the constitutively active MAPK kinase 1 (MEK CA) results in decreased energy expenditure, lowered expression of genes involved in fatty acid oxidation, increases fasting hyperglycemia and causes systemic insulin resistance. Interestingly, hepatic glycogen content is markedly increased and expression of G6Pase gene is decreased in mice over-expressing MEK CA compared to control mice expressing green fluorescent protein (GFP), therefore hepatic glucose output is not likely the major contributor of hyperglycemia. One potential mechanism of decreased expression of G6Pase gene by MEK CA is likely due to ERK mediated phosphorylation and cytosolic retention of FOXO1. Adipocytes isolated from MEK CA mice display increased lipolysis. Circulating levels of free fatty acids (FFAs) in these mice are also increased, which possibly contribute to systemic insulin resistance and subsequent hyperglycemia. Consistent with these results, knocking down ERK expression in the liver of diet induced obese (DIO) mice improves systemic insulin and glucose tolerance. These results indicate that increased hepatic ERK activity in DIO mice may contribute to increased liver glycogen content and decreased energy expenditure in obesity. PMID:23732116

  17. Exploring the Behavioral Patterns of Learners in an Educational Massively Multiple Online Role-Playing Game (MMORPG)

    ERIC Educational Resources Information Center

    Hou, Huei-Tse

    2012-01-01

    Massively multiple online role-playing games (MMORPGs) are very popular among students. Educational MMORPGs, however, are very rare, as are studies on gamers' behavioral patterns during such games. The current study is an empirical observation and analysis of the behavioral patterns of 100 gamers participating in an educational MMORPG called…

  18. The Efficacy of Some Proposed Activities For Developing Creative Thinking of English Learners at the Preparatory Stage (Second Year)

    ERIC Educational Resources Information Center

    Bakr, Samira M.

    2004-01-01

    The purpose of this study was to examine the efficacy of some proposed activities for developing creative thinking of English learners at the preparatory stage. The current study adopted the quasi- experimental design. Two groups of English learners were randomly chosen from one of Port- Said governmental preparatory schools. The experimental…

  19. Synergy between Authentic Assessment Activities and Learner Autonomy: How Does This Promote Shared Authenticity in Online Higher Education?

    ERIC Educational Resources Information Center

    Gikandi, Joyce

    2013-01-01

    The purpose of this study was to establish whether and how authentic assessment activities and learner autonomy converged to productively engage both the teacher and learners in shared authenticity. The study employed case study methodology to investigate the phenomena within an online course in ICT designed for continuing professionals in…

  20. The activity intensities reached when playing active tennis gaming relative to sedentary gaming, tennis game-play, and current activity recommendations in young adults.

    PubMed

    Scanlan, Aaron T; Arkinstall, Hayley; Dalbo, Vincent J; Humphries, Brendan J; Jennings, Cameron T; Kingsley, Michael I C

    2013-09-01

    Although active gaming is popular and can increase energy expenditure in young adults, its efficacy as a prescriptive exercise tool is not well understood. This study aimed to: (a) compare the activity intensities experienced by young adults while playing active tennis gaming with conventional sedentary gaming, tennis game-play, and current activity recommendations for health; and (b) identify changes in activity intensities across playing time. After habitualization, 10 active young adults (age: 20.2 ± 0.4 years; stature: 1.74 ± 0.03 m; body mass: 67.7 ± 3.3 kg) completed 3 experimental trials (sedentary gaming, active tennis gaming, and tennis game-play) on separate days in a randomized order. Heart rate (HR) and metabolic equivalents (METs) were averaged across 5 minutes and 10 minutes intervals, and the entire 20 minutes bout within each condition. Active gaming produced greater intensities across 5-10, 10-15, and 15-20 minutes time intervals compared with sedentary gaming (p < 0.01). Tennis game-play elicited greater HR (67 ± 5% HR(max)) and METs (5.0 ± 0.2) responses than both sedentary (40 ± 2% HR(max), 1.1 ± 0.1 METs) and active gaming (45 ± 2% HR(max), 1.4 ± 0.1 METs) (p < 0.001). Only tennis game-play produced activity intensities meeting current recommendations for health benefit. Lower HR intensities were reached across 0-5 minutes than during later time intervals during active gaming (6%) and tennis game-play (9%) (p < 0.01). Activity intensities elicited by active gaming were greater than sedentary gaming but less than tennis game-play and insufficient to contribute toward promoting and maintaining good health in young adults. These data suggest that active tennis gaming should not be recommended by exercise professionals as a substitute for actual sports participation in young adults. PMID:23238089

  1. Fluency-dependent cortical activation associated with speech production and comprehension in second language learners.

    PubMed

    Shimada, K; Hirotani, M; Yokokawa, H; Yoshida, H; Makita, K; Yamazaki-Murase, M; Tanabe, H C; Sadato, N

    2015-08-01

    This functional magnetic resonance imaging (fMRI) study investigated the brain regions underlying language task performance in adult second language (L2) learners. Specifically, we identified brain regions where the level of activation was associated with L2 fluency levels. Thirty Japanese-speaking adults participated in the study. All participants were L2 learners of English and had achieved varying levels of fluency, as determined by a standardized L2 English proficiency test, the Versant English Test (Pearson Education Inc., 2011). When participants performed the oral sentence building task from the production tasks administered, the dorsal part of the left inferior frontal gyrus (dIFG) showed activation patterns that differed depending on the L2 fluency levels: The more fluent the participants were, the more dIFG activation decreased. This decreased activation of the dIFG might reflect the increased automaticity of a syntactic building process. In contrast, when participants performed an oral story comprehension task, the left posterior superior temporal gyrus (pSTG) showed increased activation with higher fluency levels. This suggests that the learners with higher L2 fluency were actively engaged in post-syntactic integration processing supported by the left pSTG. These data imply that L2 fluency predicts neural resource allocation during language comprehension tasks as well as in production tasks. This study sheds light on the neural underpinnings of L2 learning by identifying the brain regions recruited during different language tasks across different modalities (production vs. comprehension). PMID:26026679

  2. Analyzing the Learning Process of an Online Role-Playing Discussion Activity

    ERIC Educational Resources Information Center

    Hou, Huei-Tse

    2012-01-01

    Instructional activities based on online discussion strategies have gained prevalence in recent years. Within this context, a crucial research topic is to design innovative and appropriate online discussion strategies that assist learners in attaining a deeper level of interaction and higher cognitive skills. By analyzing the process of online…

  3. Listening and Speaking Activities for Foreign Language Learners: Second Collection.

    ERIC Educational Resources Information Center

    Hendrickson, James M.

    The 30 listening and speaking activities in this collection are designed to motivate students to use foreign languages for communicating their ideas and to encourage students to be creative. The criteria for including the activities were: (1) proven effectiveness toward improving students' oral language proficiency; (2) ease of adaptability to any…

  4. Sharing a Small World: Environmental Activities for Young Learners.

    ERIC Educational Resources Information Center

    Zero Population Growth, Inc., Washington, DC.

    This booklet contains a collection of activities developed for pre-K through second grade students. All of the activities in this teacher's guide use an interdisciplinary approach and explore the human connection with all living things and their environment. Contents include: (1) "Sharing Space and Working Together"; (2) "Sharing Resources and…

  5. Influence of ball-in-play time on the activity profiles of rugby league match-play.

    PubMed

    Gabbett, Tim J

    2015-03-01

    Most investigations of the activity profiles of rugby league match-play have reported the physical demands across the entire match irrespective of stoppages in play. This study investigated the activity profiles of rugby league match-play, accounting for time when the ball was "in" and "out-of-play." One-hundred four players (mean age, 24.0 ± 3.0 years) from 11 semiprofessional rugby league teams underwent global positioning system analysis during 22 matches. Matches were coded for activity and recovery cycles. Time when the ball was continuously in play was considered activity, whereas any stoppages during the match (e.g., for scrums, penalties, line drop-outs, and tries) were considered recovery. The relative distance (125.1 ± 16.1 m·min vs. 86.7 ± 9.8 m·min), low-speed activity (115.3 ± 15.7 m·min vs. 81.7 ± 9.8 m·min), and high-speed running (9.5 ± 2.9 m·min vs. 5.0 ± 1.8 m·min) demands were significantly (p < 0.0001) higher when accounting for ball-in-play time. The frequency of collisions (0.67 ± 0.28 per minute vs. 0.41 ± 0.17 per minute) and repeated high-intensity effort (RHIE) bouts (1 every 6.1 ± 4.7 minutes vs. 1 every 10.7 ± 8.3 minutes) were also higher when stoppage time was excluded. Large negative correlations (p ≤ 0.001) were found between total ball-in-play time and relative measures of total distance (r = -0.67) and low-speed activity (r = -0.60). These results demonstrate the greater movement, contact, and RHIE demands when rugby league time-motion data are expressed relative to ball-in-play time. Furthermore, the reduction in relative intensity with longer total ball-in-play time suggests that during prolonged passages of play, players adopt a pacing strategy to maintain high-intensity performance and manage fatigue. PMID:25474332

  6. Cross-language activation in children's speech production: evidence from second language learners, bilinguals, and trilinguals.

    PubMed

    Poarch, Gregory J; van Hell, Janet G

    2012-03-01

    In five experiments, we examined cross-language activation during speech production in various groups of bilinguals and trilinguals who differed in nonnative language proficiency, language learning background, and age. In Experiments 1, 2, 3, and 5, German 5- to 8-year-old second language learners of English, German-English bilinguals, German-English-Language X trilinguals, and adult German-English bilinguals, respectively, named pictures in German and in English; in Experiment 4, 6- to 8-year-old German monolinguals named pictures in German. In both language conditions, cognate status was manipulated. We found that the bidirectional cognate facilitation effect was significant in all groups except the German monolinguals (Experiment 4) and, critically, the child second language learners (Experiment 1) in whom only native language (L1) German had an effect on second language (L2) English. The findings demonstrate how the integration of languages into a child's system follows a developmental path that, at lower levels of proficiency, allows only limited cross-language activation. The results are interpreted against the backdrop of the developing language systems of the children both for early second language learners and for early bi- and trilinguals. PMID:22138311

  7. Model Eliciting Activities: Fostering 21st Century Learners

    ERIC Educational Resources Information Center

    Stohlmann, Micah

    2013-01-01

    Real world mathematical modeling activities can develop needed and valuable 21st century skills. The knowledge and skills to become adept at mathematical modeling need to develop over time and students in the elementary grades should have experiences with mathematical modeling. For this to occur elementary teachers need to have positive…

  8. Total Participation Techniques: Making Every Student an Active Learner

    ERIC Educational Resources Information Center

    Himmele, Persida; Himmele, William

    2011-01-01

    Yes, there are easy-to-use and incredibly effective alternatives to the "stand and deliver" approach to teaching that causes so many students to tune out--or even drop out. Here's your opportunity to explore dozens of ways to engage K-12 students in active learning and allow them to demonstrate the depth of their knowledge and understanding. The…

  9. Student Choice of Anonymity for Learner Identity in Online Learning Discussion Forums

    ERIC Educational Resources Information Center

    Freeman, Mark; Bamford, Anne

    2004-01-01

    Academics have a range of learning activities and tools they can incorporate to enable students to achieve the objectives of their courses. Strategies such as role-play have been used with learners in face-to-face settings to allow students to experience learning using a range of learner identities. Yet, with the exception of role-plays,…

  10. Children's Well-Being and Involvement in Physically Active Outdoors Play in a Norwegian Kindergarten: Playful Sharing of Physical Experiences

    ERIC Educational Resources Information Center

    Bjørgen, Kathrine

    2015-01-01

    This qualitative study explores the conditions of children's level of well-being and their involvement in physically active play during kindergarten outdoors time. Observations of three to five year olds from one kindergarten in central Norway were conducted. The researcher followed the children around the kindergarten's outdoors playground and…

  11. Active Adult Play: Improving Children's Health and Behavior while Having Fun

    ERIC Educational Resources Information Center

    Nelson, Bryan G.; Uba, Gregory

    2009-01-01

    All teachers can be supportive of children's active play by running, jumping, and playing with them and by reducing the time spent simply standing around "supervising" their play. In this article, the authors describe the benefits of active play and offer some encouragement that will get teachers and their coworkers to run around with children.…

  12. Kid's Play. Activities for Adults and the Children They Love.

    ERIC Educational Resources Information Center

    Spanos-Hawkey, Dena, Ed.

    Intended for literacy students who want to share the pleasure of reading with the children they love, this book describes 26 easy, inexpensive activities to expose children to reading. Each activity explains the type of activity, lists materials needed, and provides instructions or suggestions for extending the activity. A suggested book list…

  13. Role-Play and Student Engagement: Reflections from the Classroom

    ERIC Educational Resources Information Center

    Stevens, Rachel

    2015-01-01

    Role-play is viewed by scholars as an effective active learning strategy: it encourages participation among passive learners, adds dynamism to the classroom and promotes the retention of material. But what do students think of role-play? This study surveyed 144 students after a role-play activity in a history course and asked them to identify what…

  14. Piano Playing Reduces Stress More than Other Creative Art Activities

    ERIC Educational Resources Information Center

    Toyoshima, Kumiko; Fukui, Hajime; Kuda, Kiyoto

    2011-01-01

    Few studies have been conducted on the physiological effects of creative art activities. In this study, the effects of creative art activities on human stress were investigated, and their effects were compared in 57 healthy college students (27 males and 30 females). Subjects were divided into four groups, each of which participated in 30-minute…

  15. Spondylolysis in Active Adolescents: Expediting Return to Play.

    ERIC Educational Resources Information Center

    Moeller, James L.; Rifat, Sami F.

    2001-01-01

    Spondylolysis is a common cause of back pain in active adolescents. For prolonged pain, an aggressive workup and specific diagnosis are needed. History and physical exam findings are not diagnostic. Tests beyond radiographs (computed tomography, bone scans, and magnetic resonance imaging) are necessary to determine metabolic activity and full…

  16. "LET US Play": Maximizing Physical Activity "in" Physical Education

    ERIC Educational Resources Information Center

    Weaver, R. Glenn; Webster, Collin; Beets, Michael W.

    2013-01-01

    Schools have been identified as a promising setting for increasing youth physical activity levels because of their broad reach and the amount of time youth spend in attendance. Specifically, physical education is one key time during the school day where youth can accumulate health-enhancing levels of physical activity. Indicators of quality…

  17. Footballs versus Barbies: Childhood Play Activities as Predictors of Sport Participation by Women.

    ERIC Educational Resources Information Center

    Guiliano, Traci A.; Popp, Kathryn E.; Knight, Jennifer L.

    2000-01-01

    Examined the extent to which women's childhood play activities predicted future sport participation. College athletes and nonathletes completed a survey on childhood play and adult sports experiences. Playing with masculine toys and games, playing in predominantly male or mixed groups, and being a tomboy characterized women who later became…

  18. Active Learning by Play Dough Modeling in the Medical Profession

    ERIC Educational Resources Information Center

    Herur, Anita; Kolagi, Sanjeev; Chinagudi, Surekharani; Manjula, R.; Patil, Shailaja

    2011-01-01

    Active learning produces meaningful learning, improves attitudes toward learning, and increases knowledge and retention, but is still not fully institutionalized in the undergraduate sciences. A few studies have compared the effectiveness of PowerPoint presentations, student seminars, quizzes, and use of CD-ROMs with blackboard teaching and…

  19. Physically Active Play and Cognition: An Academic Matter?

    ERIC Educational Resources Information Center

    Sattelmair, Jacob; Ratey, John J.

    2009-01-01

    The authors discuss the growing evidence that strenuous physical activity is not only healthy for students but improves their academic performance. Based on such research, they argue that schools in the United States need to stop eliminating physical-education programs under the current political pressures to emphasize academics and instead to…

  20. Active Learning in the Classroom: The Use of Group Role Plays.

    ERIC Educational Resources Information Center

    Kitzerow, Phyllis

    1990-01-01

    Describes group role-playing activities that have been used to teach about education, criminology, and sex roles. Suggests that role play helps students to absorb and retain many of the insights about the issues involved. (DB)

  1. Innovative Strategies for Empowering Your Students to Become Active, Responsible Learners

    NASA Astrophysics Data System (ADS)

    Hufnagel, B.

    2011-09-01

    The economy continues to sputter along, and the repercussions are now hitting hard at publicly-funded colleges and universities, with enrollment increasing and funding decreasing. Funding agencies are starting to look at retention and completion rates as a way to allocate scarce dollars. Improving these rates is also one way to increase the future stream of tuition; students who can't pass introductory classes like ASTRO101 won't enroll and pay tuition for the next level, and they won't complete their degree. So what can you, a mere professor of astronomy, do? Tired of the "What do you want me to know?" questions? Provide your students with learner-centered structures to help them learn more deeply. Do your students resist active-engagement techniques and hate group work? Share empowerment strategies for helping students become active, responsible learners who can thrive in a learner-centered environment. Do you think that it's wrong for the freshman classes to be over-crowded, yet your sophomore classes don't get enough students or don't even exist? After using the proven curriculum of On Course, college and universities across the country have improved their retention across a wide range of disciplines (http://www.OnCourseWorkshop.com/Data.htm). Experience a sample of the fun and engaging activities developed over two decades to help students (1) accept personal responsibility, (2) discover self motivation, (3) master self-management, (4) use interdependence, (5) gain self-awareness, (6) adopt lifelong learning, (7) develop emotional intelligence, and (8) believe in themselves. Since this is only a one-hour workshop, we will focus on choices one and four: to be successful, students need to see themselves as the primary cause of their outcomes and experiences and to build mutually supportive relationships in our classroom and labs. Outcomes: (1) one ASTRO101 Course-ready activity to help students accept personal responsibility; (2) one ASTRO101 Course

  2. Parent participation plays an important part in promoting physical activity

    PubMed Central

    Lindqvist, Anna-Karin; Kostenius, Catrine; Gard, Gunvor; Rutberg, Stina

    2015-01-01

    Although physical activity (PA) is an important and modifiable determinant of health, in Sweden only 15% of boys and 10% of girls aged 15 years old achieve the recommended levels of PA 7 days per week. Adolescents’ PA levels are associated with social influence exerted by parents, friends, and teachers. The purpose of this study was to describe parents’ experiences of being a part of their adolescents’ empowerment-inspired PA intervention. A qualitative interview study was performed at a school in the northern part of Sweden. A total of 10 parents were interviewed, and the collected data were analyzed with qualitative content analysis. Three subthemes were combined into one main theme, demonstrating that parents are one important part of a successful PA intervention. The life of an adolescent has many options and demands that make it difficult to prioritize PA. Although parents felt that they were important in supporting their adolescent, a successful PA intervention must have multiple components. Moreover, the parents noted that the intervention had a positive effect upon not only their adolescents’, but also their own PA. Interventions aimed at promoting PA among adolescents should include measures to stimulate parent participation, have an empowerment approach, and preferably be school-based. PMID:26282870

  3. p21-Activated Kinase 1 Plays a Critical Role in Cellular Activation by Nef

    PubMed Central

    Fackler, Oliver T.; Lu, Xiaobin; Frost, Jeffrey A.; Geyer, Matthias; Jiang, Bing; Luo, Wen; Abo, Arie; Alberts, Arthur S.; Peterlin, B. Matija

    2000-01-01

    The activation of Nef-associated kinase (NAK) by Nef from human and simian immunodeficiency viruses is critical for efficient viral replication and pathogenesis. This induction occurs via the guanine nucleotide exchange factor Vav and the small GTPases Rac1 and Cdc42. In this study, we identified NAK as p21-activated kinase 1 (PAK1). PAK1 bound to Nef in vitro and in vivo. Moreover, the induction of cytoskeletal rearrangements such as the formation of trichopodia, the activation of Jun N-terminal kinase, and the increase of viral production were blocked by an inhibitory peptide that targets the kinase activity of PAK1 (PAK1 83-149). These results identify NAK as PAK1 and emphasize the central role its kinase activity plays in cytoskeletal rearrangements and cellular signaling by Nef. PMID:10713183

  4. 'Active play may be lots of fun, but it's certainly not frivolous': the emergence of active play as a health practice in Canadian public health.

    PubMed

    Alexander, Stephanie A; Frohlich, Katherine L; Fusco, Caroline

    2014-11-01

    In the context of what has been termed a childhood obesity epidemic, public health institutions have recently begun to promote active play as a means of addressing childhood obesity, thus advancing play for health. Drawing on Foucault, this article problematises the way that children's play is being taken up as a health practice and further considers some of the effects this may have for children. Six Canadian public health websites were examined, from which 150 documents addressing children's health, physical activity, obesity, leisure activities and play were selected and coded deductively (theoretical themes) and inductively (emerging themes). Bacchi's () question-posing approach to critical discourse analysis deepened our analysis of dominant narratives. Our findings suggest that several taken-for-granted assumptions and practices underlie this discourse: (i) play is viewed as a productive activity legitimises it as a health practice; (ii) tropes of 'fun' and 'pleasure' are drawn on to promote physical activity; (iii) children are encouraged to self-govern their leisure time to promote health. We underscore the need to recognise this discourse as contingent and as only one of many ways of conceptualising children's leisure activities and their health and social lives more generally. PMID:24915830

  5. Influences of Technology-Related Playful Activity and Thought on Moral Development

    ERIC Educational Resources Information Center

    Bergen, Doris; Davis, Darrel

    2011-01-01

    Many early developmental theorists such as Freud, Erikson, Piaget, and Vygotsky suggested that play--which the authors of this article define as both playful activity and playful thought--had the power to influence the moral emotions, behaviors, and reasoning of children. More recent researchers have also found evidence of moral development in…

  6. The Impact of Vocabulary Enhancement Activities on Vocabulary Acquisition and Retention among Male and Female EFL Learners in Iran

    ERIC Educational Resources Information Center

    Sharafi-Nejad, Maryam; Raftari, Shohreh; Bijami, Maryam; Khavari, Zahra; Ismail, Shaik Abdul Malik Mohamed; Eng, Lin Siew

    2014-01-01

    In general, incidental vocabulary acquisition is represented as the "picking up" of new vocabularies when students are engaged in a variety of reading, listening, speaking, or writing activities. Research has shown when learners read extensively incidental vocabulary acquisition happens. Many EFL students cannot be involved in reading…

  7. MAI (Multi-Dimensional Activity Based Integrated Approach): A Strategy for Cognitive Development of the Learners at the Elementary Stage

    ERIC Educational Resources Information Center

    Basantia, Tapan Kumar; Panda, B. N.; Sahoo, Dukhabandhu

    2012-01-01

    Cognitive development of the learners is the prime task of each and every stage of our school education and its importance especially in elementary state is quite worth mentioning. Present study investigated the effectiveness of a new and innovative strategy (i.e., MAI (multi-dimensional activity based integrated approach)) for the development of…

  8. Comparison of the Effects of Reflection and Contemplation Activities on Service-Learners' Cognitive and Affective Mindfulness

    ERIC Educational Resources Information Center

    Stewart, Trae; Alrutz, Megan

    2012-01-01

    This study investigates the extent to which service-learners' mindfulness is affected by engagement in reflection (e.g., dialogue) and contemplation activities (e.g., labyrinth tracing). The results are compared within and between treatment groups, while covarying for participants' initial levels of mindfulness. While both dialogue and…

  9. From Passive to Active Learners: The "Lived Experience" of Nurses in a Specialist Nephrology Nursing Education Programme

    ERIC Educational Resources Information Center

    Bridger, Jane

    2007-01-01

    Purpose: This study aims to explore the lived experience of learning for a group of staff nurses in the Middle East, who undertook a post-registration nursing education programme in the speciality of nephrology nursing (the NNP) between 2001 and 2002. The broad-based curriculum seeks to develop the staff nurses into active learners, able to…

  10. When Are Powerful Learning Environments Effective? The Role of Learner Activities and of Students' Conceptions of Educational Technology

    ERIC Educational Resources Information Center

    Gerjets, Peter H.; Hesse, Friedrich W.

    2004-01-01

    The goal of this chapter is to outline a theoretical and empirical perspective on how learners' conceptions of educational technology might influence their learning activities and thereby determine the power of computer-based learning environments. Starting with an introduction to the concept of powerful learning environments we outline how recent…

  11. Identifying and Enhancing the Strengths of Gifted Learners, K-8: Easy-to-Use Activities and Lessons

    ERIC Educational Resources Information Center

    Maccagnano, Ann Marie

    2007-01-01

    Educators can identify children's strengths early on and gain insight into each student's unique abilities by using the numerous ideas and informal assessments in this exciting guide. Gifted and talented specialist Ann Maccagnano offers K-8 teachers challenging activities and engaging lessons to develop and nurture gifted learners' talents.…

  12. Energy expended playing video console games: an opportunity to increase children's physical activity?

    PubMed

    Maddison, Ralph; Mhurchu, Cliona Ni; Jull, Andrew; Jiang, Yannan; Prapavessis, Harry; Rodgers, Anthony

    2007-08-01

    This study sought to quantify the energy expenditure and physical activity associated with playing the "new generation" active and nonactive console-based video games in 21 children ages 10-14 years. Energy expenditure (kcal) derived from oxygen consumption (VO2) was continuously assessed while children played nonactive and active console video games. Physical activity was assessed continuously using the Actigraph accelerometer. Significant (p < .001) increases from baseline were found for energy expenditure (129-400%), heart rate (43-84%), and activity counts (122-1288 versus 0-23) when playing the active console video games. Playing active console video games over short periods of time is similar in intensity to light to moderate traditional physical activities such as walking, skipping, and jogging. PMID:18019591

  13. Integration of Structured Expressive Activities within a Humanistic Group Play Therapy Format for Preadolescents

    ERIC Educational Resources Information Center

    Bratton, Sue C.; Ceballos, Peggy L.; Ferebee, Kelly Webb

    2009-01-01

    The integration of expressive activities in play groups with preadolescents encourages them to reach more deeply into their own resources, enabling them to handle future challenges more effectively. Developmental and therapeutic rationale, along with research support, is given for the integration of creative activities into a humanistic play group…

  14. Comparing Role-Playing Activities in Second Life and Face-to-Face Environments

    ERIC Educational Resources Information Center

    Gao, Fei; Noh, Jeongmin J.; Koehler, Matthew J.

    2009-01-01

    This study compared student performances in role-playing activities in both a face-to-face (FTF) environment and a virtual 3D environment, Second Life (SL). We found that students produced a similar amount of communication in the two environments, but the communication styles were different. In SL role-playing activities, students took more…

  15. Teachers' Beliefs Related to Activity Play in the Preschool Setting: A Phenomenological Investigation

    ERIC Educational Resources Information Center

    Pisha, Lorelei Emma

    2012-01-01

    The purpose of the present study was to investigate how early childhood teachers working in Head Start programs made meaning of preschool-age children's physical activity play by exploring their personal childhood and professional experiences with physical activity play. The study was conducted to contribute research-based recommendations for…

  16. Physical Activity Play and Preschool Children's Peer Acceptance: Distinctions between Rough-and-Tumble and Exercise Play

    ERIC Educational Resources Information Center

    Lindsey, Eric W.

    2014-01-01

    Research Findings: Two forms of exercise play (toy mediated and non-mediated) and 2 forms of rough-and-tumble (R&T) play (chase and fighting) were examined in relation to preschoolers' peer competence. A total of 148 preschoolers (78 boys, 89 Euro-Americans) were observed during free play at their university-sponsored child care center.…

  17. CALL and the Development of Learner Autonomy: Towards an Activity-Theoretical Perspective

    ERIC Educational Resources Information Center

    Blin, Francoise

    2004-01-01

    While the concepts and principles associated with learner autonomy underpin a broad range of CALL applications and research projects, current debates and research paradigms in CALL do not provide adequate tools and models to investigate in depth the relationship between CALL and the development of learner autonomy. This paper explores the…

  18. Elementary School EFL Learners' Vocabulary Learning: The Effects of Post-Reading Activities

    ERIC Educational Resources Information Center

    Atay, Derin; Kurt, Gokce

    2006-01-01

    As language learning involves the acquisition of thousands of words, teachers and learners alike would like to know how vocabulary learning can be fostered, especially in EFL settings where learners frequently acquire impoverished lexicons, despite years of formal study. Research indicates that reading is important but not sufficient for…

  19. Using Web-Based Instruction to Promote Active Learning: Learners' Perspectives

    ERIC Educational Resources Information Center

    Lee, Lina

    2005-01-01

    This article reports classroom research on learners' perspectives on Web-based instruction that utilizes the "Blackboard" course management system. The Web-based instruction aims to provide and support collaborative learning while fostering learners' autonomy and accountability. The article also provides a description of the course design along…

  20. Analysis of upper arm muscle activation using surface electromyography signals during drum playing.

    PubMed

    Chong, Hyun Ju; Kwon, Chun-Ki; Kang, Hyun-Joo; Kim, Soo Ji

    2016-06-01

    This study measured surface electromyography of the biceps brachii and triceps brachii during repeated drum playing with and without a drumstick to better understand activation of the upper arm muscles and inform the use of instrument playing for motor rehabilitation. A total of 40 healthy college students participated in this study. All participants were asked to strike a drum with their hand and with a drumstick at three different levels of stroke: soft, medium, and strong. The stroke order was randomly assigned to participants. A sound level meter was used to record the intensity of the drum playing. Surface electromyography signals were recorded at every hit during drum playing both with and without the drumstick in each of the three stroke conditions. The results demonstrated that the highest muscle activation was observed in both biceps brachii and triceps brachii with strong drum playing with and without the drumstick. A two-way repeated measures analysis of variance showed that there was a significant main effect for stroke intensity in muscle activation and produced sound level. While higher activation of the triceps brachii was observed for drum playing without a drumstick, no significant differences were found between the biceps brachii and sound level. This study demonstrated via surface electromyography data that greater muscle activation of the biceps brachii and triceps brachii does not occur with the use of drumsticks in drum playing. With the drum sound controlled, drum playing by hand can be an effective therapeutic intervention for the upper arm muscles. PMID:27419114

  1. Analysis of upper arm muscle activation using surface electromyography signals during drum playing

    PubMed Central

    Chong, Hyun Ju; Kwon, Chun-Ki; Kang, Hyun-Joo; Kim, Soo Ji

    2016-01-01

    This study measured surface electromyography of the biceps brachii and triceps brachii during repeated drum playing with and without a drumstick to better understand activation of the upper arm muscles and inform the use of instrument playing for motor rehabilitation. A total of 40 healthy college students participated in this study. All participants were asked to strike a drum with their hand and with a drumstick at three different levels of stroke: soft, medium, and strong. The stroke order was randomly assigned to participants. A sound level meter was used to record the intensity of the drum playing. Surface electromyography signals were recorded at every hit during drum playing both with and without the drumstick in each of the three stroke conditions. The results demonstrated that the highest muscle activation was observed in both biceps brachii and triceps brachii with strong drum playing with and without the drumstick. A two-way repeated measures analysis of variance showed that there was a significant main effect for stroke intensity in muscle activation and produced sound level. While higher activation of the triceps brachii was observed for drum playing without a drumstick, no significant differences were found between the biceps brachii and sound level. This study demonstrated via surface electromyography data that greater muscle activation of the biceps brachii and triceps brachii does not occur with the use of drumsticks in drum playing. With the drum sound controlled, drum playing by hand can be an effective therapeutic intervention for the upper arm muscles. PMID:27419114

  2. Cellular activation in limbic brain systems during social play behaviour in rats

    PubMed Central

    van Kerkhof, Linda W.M.; Trezza, Viviana; Mulder, Tessa; Gao, Ping; Voorn, Pieter; Vanderschuren, Louk J.M.J.

    2013-01-01

    Positive social interactions during the juvenile and adolescent phases of life are essential for proper social and cognitive development in mammals, including humans. During this developmental period, there is a marked increase in peer-peer interactions, signified by the abundance of social play behaviour. Despite its importance for behavioural development, our knowledge of the neural underpinnings of social play behaviour is limited. Therefore, the purpose of this study was to map the neural circuits involved in social play behaviour in rats. This was achieved by examining cellular activity after social play using the immediate early gene c-fos as a marker. After a session of social play behaviour, pronounced increases in c-fos expression were observed in the medial prefrontal cortex, medial and ventral orbitofrontal cortex, dorsal striatum, nucleus accumbens core and shell, lateral amygdala, several thalamic nuclei, dorsal raphe and the pedunculopontine tegmental nucleus. Importantly, the cellular activity patterns after social play were topographically organised in this network, as indicated by play-specific correlations in c-fos activity between regions with known direct connections. These correlations suggest involvement in social play behaviour of the projections from the medial prefrontal cortex to the striatum, and of amygdala and monoaminergic inputs to frontal cortex and striatum. The analyses presented here outline a topographically organised neural network implicated in processes such as reward, motivation and cognitive control over behaviour, which mediates social play behaviour in rats. PMID:23670540

  3. Motivation within Role-Playing as a Means to Intensify College Students' Educational Activity

    ERIC Educational Resources Information Center

    Burenkova, Olga Mikhailovna; Arkhipova, Irina Vladimirovna; Semenov, Sergei Aleksandrovich; Samarenkina, Saniya Zakirzyanovna

    2015-01-01

    This article covers college students' educational activity issues while studying a foreign language; analyzes special aspects of motivation introduction, their specific features. It also defines role and structure of role-playing. The authors come to the conclusion that introduction of role-playing in an educational process will bring it closer to…

  4. Using Activity Theory to Understand Intergenerational Play: The Case of Family Quest

    ERIC Educational Resources Information Center

    Siyahhan, Sinem; Barab, Sasha A.; Downton, Michael P.

    2010-01-01

    We implemented a five-week family program called "Family Quest" where parents and children ages 9 to 13 played Quest Atlantis, a multiuser 3D educational computer game, at a local after-school club for 90-minute sessions. We used activity theory as a conceptual and an analytical framework to study the nature of intergenerational play, the…

  5. An Integrated Play-Based Curriculum for Young Children

    ERIC Educational Resources Information Center

    Saracho, Olivia N.

    2011-01-01

    Play provides young children with the opportunity to express their ideas, symbolize, and test their knowledge of the world. It provides the basis for inquiry in literacy, science, social studies, mathematics, art, music, and movement. Through play, young children become active learners engaged in explorations about themselves, their community, and…

  6. Creative Play Activities for Children with Disabilities: A Resource Book for Teachers and Parents. Second Edition.

    ERIC Educational Resources Information Center

    Morris, Lisa Rappaport; Schulz, Linda

    This book provides 250 games and activities designed to help infants to 8-year-olds with all types of disabilities grow through play. Many activities come with special adaptations for children with physical, visual, hearing, emotional, and cognitive impairments. Each chapter focuses on a particular "world" or activity theme. Topics of individual…

  7. Measurements of Heart Rate and Accelerometry to Determine the Physical Activity Level in Boys Playing Paintball

    PubMed Central

    JARVI, MICHELLE; BROWN, GREGORY A; SHAW, BRANDON S.; SHAW, INA

    2013-01-01

    Paintball is a popular recreational sport played by 3.655 million Americans and may be sufficient physical activity to promote health. Paintball has been played as an organized sport since the 1980’s and is essentially a game of tag, except instead of touching an opponent by hand opponents are tagged by shooting them with a paintball that leaves a mark indicating who has been eliminated. A previous evaluation of paintball as physical activity had 13 subjects undergo a VO2max test to develop a heart rate (HR) /oxygen consumption relationship, and it was observed that heart rates during paintball were 68–73% of the measured maximal HR. The present study used accelerometry and HR monitors to evaluate the quantity and intensity of physical activity in boys playing paintball. Eleven boys (12.7 ± 1.0 y, 51.5 ± 11.3 kg, 161.8 ± 10.1 cm) engaged in a VO2max test to develop a HR/oxygen consumption correlation. On a separate day the boys played 7 games of outdoor paintball while wearing a HR monitor and accelerometer. The boys played paintball for 11.5 ± 6.2 minutes/game for a total of 80.6 ± 10.0 minutes of game play. Average HR during paintball play was 129.6 ± 6.6 beats/min, representing 39.9 ± 12.9% VO2max. Based on accelerometry, the boys accumulated 63.2 ± 15.6 minutes of moderate intensity activity and 2.6 ± 2.8 minutes of vigorous activity during paintball. These data suggest that playing paintball may be considered as physical activity that is > 3 METs, and thus health promoting. PMID:27182396

  8. Block Play: The Complete Guide to Learning and Playing with Blocks.

    ERIC Educational Resources Information Center

    MacDonald, Sharon

    Based on the view that blocks are a tool that preschool teachers can use to teach all the skills and concepts necessary for children to be successful learners, this guide presents over 50 activities to enhance the preschool and kindergarten classroom's block corner. Chapter 1 of the guide illustrates the skills learned through block play in the…

  9. Investigative Research: How It Changes Learner Status.

    ERIC Educational Resources Information Center

    Kenny, Brian

    1993-01-01

    What matters about an educational activity is how learners respond to it. This article examines a program concerned with the learners' needs, through the expression of learners' own meanings, and advances the concept of investigative research as a suitable vehicle for more autonomous learning, through a change in learner status. (26 references)…

  10. Participation in play activities: a single-case study focusing on a child with obesity experiences.

    PubMed

    Skär, Lisa; Prellwitz, Maria

    2008-06-01

    The purpose of this study was to describe how a child with obesity perceived participation in play activities. A single-case study design was chosen to optimize the understanding of the complexities of the research question. A 9-year-old boy diagnosed with obesity was studied. This is a typical case and is studied mainly to provide understanding to the issue. The data were collected from interviews with the boy, his mother and his teacher. Data were also collected through observations and a self-report assessment instrument called Kid Play Profile. The results showed that the boy was ridiculed by his peers and that at times he felt excluded from them, which prevented him from participating in play activities. The boy's experience came from different perceived problems such as lack of friends to play with, his inability to know how to perform in different play activities, and lack of proper support and encouragement from adults. Supporting children to overcome social skills deficits could prevent them from being teased and may have a positive effect on health. To optimize children's participation in play activities, it is important for adults to give them proper support and encouragement. The results were discussed with regard to earlier research, and topics for further research are suggested. PMID:18489691

  11. Read, Play, and Learn! Storybook Activities for Young Children. The Transdisciplinary Play-Based Curriculum. Collection 1: Modules 1-8.

    ERIC Educational Resources Information Center

    Linder, Toni W.

    Read, Play, and Learn is a play-based curriculum designed to promote growth across all of the areas of development important to a young child. With a school-year's worth of ready-to-use lessons or modules, the curriculum provides story-related activities centered around themes such as enjoying seasonal festivities, sharing emotions, making…

  12. Read, Play, and Learn! Storybook Activities for Young Children. The Transdisciplinary Play-Based Curriculum. Collection 2: Modules 9-16.

    ERIC Educational Resources Information Center

    Linder, Toni W.

    Read, Play, and Learn is a play-based curriculum designed to promote growth across all of the areas of development important to a young child. With a school-year's worth of ready-to-use lessons or modules, the curriculum provides story-related activities centered around themes such as enjoying seasonal festivities, sharing emotions, making…

  13. Solitary-Functional Play and Solitary-Pretend Play: Another Look at the Construct of Solitary-Active Behavior Using Playground Observations

    ERIC Educational Resources Information Center

    Nelson, Larry J.; Hart, Craig H.; Evans, Cortney A.

    2008-01-01

    Although the construct of solitary-active behavior calls for the aggregation of solitary-functional play and solitary-pretend play, there is little empirical support for combining them into one construct. Furthermore, little work has been done in early childhood to examine these behaviors on the playground. The purpose of this study was to observe…

  14. Children with Autism Spectrum Disorder and Patterns of Participation in Daily Physical and Play Activities

    PubMed Central

    Memari, Amir Hossein; Panahi, Nekoo; Ranjbar, Elaheh; Moshayedi, Pouria; Shafiei, Masih; Kordi, Ramin; Ziaee, Vahid

    2015-01-01

    Autism spectrum disorder (ASD) indicates several neurodevelopmental impairments which may end in impairments in motor or physical activities. Daily physical activity involvement was investigated in a total of 83 children (52 boys and 31 girls) with ASD aged 6–15 years. Results indicated that only 10 (12%) of children with ASD were physically active. Children were predominantly engaged in solitary play rather than social play activities. Gender, family income, and household structure were found to be associated with activity scores. Financial burden and lack of opportunities were noted as the leading barriers to physical activities. In conclusion, findings indicated a low rate of physical activity participation in children with ASD that is closely associated with sociodemographic variables. PMID:26171247

  15. Is Father-Child Rough-and-Tumble Play Associated with Attachment or Activation Relationships?

    ERIC Educational Resources Information Center

    Paquette, Daniel; Dumont, Caroline

    2013-01-01

    The activation relationship theory, primarily focused on parental stimulation of risk-taking along with parental control during exploration, predicts that boys will be activated more than girls by their fathers. This theory may explain why fathers engage in rough-and-tumble play (RTP) with children more frequently than mothers, especially with…

  16. Understanding Our Environment: Challenge. Clear Water Challenge: A Role Play Activity.

    ERIC Educational Resources Information Center

    Lieblich, Suzanne, Ed.

    Part of the Understanding Our Environment project that is designed to engage students in investigating specific environmental problems through concrete activity and direct experience, this unit contains a role-play activity in the form of a public inquiry into the cause of a fish kill on a river that runs through the fictional town of Oakwood. A…

  17. Playing "The Ladybug Game": Parent Guidance of Young Children's Numeracy Activities

    ERIC Educational Resources Information Center

    Vandermaas-Peeler, Maureen; Ferretti, Larissa; Loving, Sara

    2012-01-01

    Parent guidance for numeracy activities and preschoolers' numeracy performance were examined in the context of playing a board game in three sessions over a two-week period. Twenty-eight parent-child dyads were randomly assigned to a numeracy awareness group in which parents were provided with suggested numeracy activities to incorporate into the…

  18. Affordances in Outdoor Environments and Children's Physically Active Play in Pre-School

    ERIC Educational Resources Information Center

    Storli, Rune; Hagen, Trond Loge

    2010-01-01

    The purpose of this article is to quantitatively and qualitatively explore children's physically active play outdoors in a traditional playground and natural (nature) environment and discuss how these environments influence children's physical activity. Fjortoft has previously explored the relationship between environmental affordances and…

  19. Role Play Simulations: The Assessment of an Active Learning Technique and Comparisons with Traditional Lectures.

    ERIC Educational Resources Information Center

    DeNeve, Kristina; Heppner, Mary J.

    1997-01-01

    Use of active learning techniques of role-playing and simulation in an industrial psychology course (n=29 students) is described and assessed. Subjective reports and objective assessments of knowledge retention indicate the approach was effective. The differential importance of active learning and passive learning (lecture) in the college…

  20. Influencing Preschoolers' Free-Play Activity Preferences: An Evaluation of Satiation and Embedded Reinforcement

    ERIC Educational Resources Information Center

    Hanley, Gregory P.; Tiger, Jeffrey H.; Ingvarsson, Einar T.; Cammilleri, Anthony P.

    2009-01-01

    The present study evaluated the effects of classwide satiation and embedded reinforcement procedures on preschoolers' activity preferences during scheduled free-play periods. The goal of the study was to increase time allocation to originally nonpreferred, but important, activities (instructional zone, library, and science) while continuing to…

  1. Plan before You Play: An Activity for Teaching the Managerial Process

    ERIC Educational Resources Information Center

    Althouse, Norm R.; Hedges, Peggy L.

    2015-01-01

    This article describes a 60-minute classroom activity using LEGO® bricks that demonstrates and reinforces the importance of the managerial process. The activity, Plan Before You Play (PBP), is targeted to introductory business classes, and differs from others in that it requires little investment or up-front planning, is easily scalable, and, with…

  2. Narrative increases step counts during active video game play among children

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Active video games (AVGs) capable of inducing physical activity (PA) level offer a novel alternative to child obesity. Unfortunately, children's motivation to play AVG decreases quickly, underscoring the need to find new methods to maintain their engagement. According to narrative transportation th...

  3. Where they live, how they play: Neighborhood greenness and outdoor physical activity among preschoolers

    PubMed Central

    2011-01-01

    Background Emerging empirical evidence suggests exposure to "green" environments may encourage higher levels of physical activity among children. Few studies, however, have explored this association exclusively in pre-school aged children in the United States. We examined whether residing in neighborhoods with higher levels of greenness was associated with higher levels of outdoor physical activity among preschoolers. In addition, we also explored whether outdoor playing behaviors (e.g., active vs. quiet) were influenced by levels of neighborhood greenness independent of demographic and parental support factors. Results Higher levels of neighborhood greenness as measured by the Normalized Difference Vegetation Index (NDVI) was associated with higher levels of outdoor playing time among preschool-aged children in our sample. Specifically, a one unit increase in neighborhood greenness increased a child's outdoor playing time by approximately 3 minutes. A dose-response relationship was observed between increasing levels of parental support for physical activity (e.g., time spent playing with children) and child outdoor physical activity (p < 0.01). Conclusions Consistent with previous studies, neighborhood greenness influences physical activity behavior. However, for preschoolers, parental involvement may be more critical for improving physical activity levels. PMID:22165919

  4. HybridPLAY: A New Technology to Foster Outdoors Physical Activity, Verbal Communication and Teamwork.

    PubMed

    Díaz, Diego José; Boj, Clara; Portalés, Cristina

    2016-01-01

    This paper presents HybridPLAY, a novel technology composed of a sensor and mobile-based video games that transforms urban playgrounds into game scenarios. With this technology we aim to stimulate physical activity and playful learning by creating an entertaining environment in which users can actively participate and collaborate. HybridPLAY is different from other existing technologies that enhance playgrounds, as it is not integrated in them but can be attached to the different elements of the playgrounds, making its use more ubiquitous (i.e., not restricted to the playgrounds). HybridPLAY was born in 2007 as an artistic concept, and evolved after different phases of research and testing by almost 2000 users around the world (in workshops, artistic events, conferences, etc.). Here, we present the temporal evolution of HybridPLAY with the different versions of the sensors and the video games, and a detailed technical description of the sensors and the way interactions are produced. We also present the outcomes after the evaluation by users at different events and workshops. We believe that HybridPLAY has great potential to contribute to increased physical activity in kids, and also to improve the learning process and monitoring at school centres by letting users create the content of the apps, leading to new narratives and fostering creativity. PMID:27120601

  5. HybridPLAY: A New Technology to Foster Outdoors Physical Activity, Verbal Communication and Teamwork

    PubMed Central

    Díaz, Diego José; Boj, Clara; Portalés, Cristina

    2016-01-01

    This paper presents HybridPLAY, a novel technology composed of a sensor and mobile-based video games that transforms urban playgrounds into game scenarios. With this technology we aim to stimulate physical activity and playful learning by creating an entertaining environment in which users can actively participate and collaborate. HybridPLAY is different from other existing technologies that enhance playgrounds, as it is not integrated in them but can be attached to the different elements of the playgrounds, making its use more ubiquitous (i.e., not restricted to the playgrounds). HybridPLAY was born in 2007 as an artistic concept, and evolved after different phases of research and testing by almost 2000 users around the world (in workshops, artistic events, conferences, etc.). Here, we present the temporal evolution of HybridPLAY with the different versions of the sensors and the video games, and a detailed technical description of the sensors and the way interactions are produced. We also present the outcomes after the evaluation by users at different events and workshops. We believe that HybridPLAY has great potential to contribute to increased physical activity in kids, and also to improve the learning process and monitoring at school centres by letting users create the content of the apps, leading to new narratives and fostering creativity. PMID:27120601

  6. Role Engagement and Anonymity in Synchronous Online Role Play

    ERIC Educational Resources Information Center

    Cornelius, Sarah; Gordon, Carole; Harris, Margaret

    2011-01-01

    Role play activities provide opportunities for learners to adopt unfamiliar roles, engage in interactions with others, and get involved in realistic tasks. They are often recommended to foster the development of soft skills and a wider perspective of the world. Such activities are widely used as an online teaching approach, with examples ranging…

  7. Active play exercise intervention in children with asthma: a PILOT STUDY

    PubMed Central

    Westergren, Thomas; Fegran, Liv; Nilsen, Tonje; Haraldstad, Kristin; Kittang, Ole Bjørn; Berntsen, Sveinung

    2016-01-01

    Objective Increased physical activity (PA) may be beneficial for children with asthma. Knowledge about how to intervene and encourage children with asthma to be physically active is required. In the present study, we aimed to pilot a 6-week exercise intervention designed as active play and examine attendance rate, exercise intensity and children's perceptions of participating. Methods 6 children with asthma (4 boys, 2 girls) aged 10–12 years, participated in 60 min of active play exercise twice weekly. A mixed-methods design was applied. The data analysed included attendance rate, exercise intensity assessed by heart rate (HR) monitoring during exercise sessions, registration and description of the active play exercise programme, 3 semistructured focus groups, field observations of 5 exercise sessions, and preintervention and postintervention testing. Findings The average attendance rate was 90%. Intensity ≥80% of maximal HR (HRmax) was recorded for a median (IQR) time of 22 (8) out of 60 min per session. Median (IQR) HR during the sessions was 146 (9; 74% of HRmax) bpm. Children reported increased health-related quality of life (HRQoL) post-test compared with baseline. Children enjoyed participating and reported no limitations by asthma or serious asthma attacks. Instead, they perceived that their asthma and fitness had improved after the programme. The instructors created an inclusive atmosphere that was characterised by easy-to-master games, fair competition, humour and mutual participation. Conclusions The exercise intervention pilot focusing on active play had a high attendance rate, relatively high exercise intensity, and satisfaction; the children perceived that their fitness and asthma had improved, and reported increased HRQoL. A randomised controlled trial of active play exercise including children with asthma should be conducted to evaluate effect on PA level, physical fitness, asthma control and HRQoL. PMID:26733570

  8. Impact of Consciousness-Raising Activities on Young English Language Learners' Grammar Performance

    ERIC Educational Resources Information Center

    Fatemipour, Hamidreza; Hemmati, Shiva

    2015-01-01

    Grammar Consciousness-Raising (GCR) is an approach to teaching of grammar which learners instead of being taught the given rules, experience language data. The data challenge them to rethink, restructure their existing mental grammar and construct an explicit rule to describe the grammatical feature which the data illustrate (Ellis, 2002). And…

  9. Fostering Active Processing of Instructional Explanations of Learners with High and Low Prior Knowledge

    ERIC Educational Resources Information Center

    Acuna, Santiago R.; Garcia Rodicio, Hector; Sanchez, Emilio

    2011-01-01

    Despite the potential advantages of instructional explanations, evidence indicates that they are usually ineffective. Subsequent work has shown that in order to make instructional explanations effective indeed, one successful strategy is to combine them with indications of the limitations in learners' understanding that they are intended to…

  10. Developing Learners' Second Language Communicative Competence through Active Learning: Clickers or Communicative Approach?

    ERIC Educational Resources Information Center

    Agbatogun, Alaba Olaoluwakotansibe

    2014-01-01

    The purpose of this study was to compare the impact of clickers, the communicative approach and the lecture method on the communicative competence development of learners who were taught English a second language (ESL). Ninety nine pupils from three primary schools participated in the study. Quasi-experimental non-randomised pre-test posttest…

  11. An Analysis of Spanish L2 Learners' Orientation through Activity Theory

    ERIC Educational Resources Information Center

    Tocaimaza-Hatch, C. Cecilia

    2015-01-01

    Orientation is defined as the way in which individuals view a task and the means they devise to fulfill it (Appel & Lantolf, 1994; Roebuck, 2000). This study investigated the orientation of twelve learners enrolled in a fourth-semester Spanish L2 university course through the analysis of their interactions during a collaborative…

  12. Online Social Networks as Formal Learning Environments: Learner Experiences and Activities

    ERIC Educational Resources Information Center

    Veletsianos, George; Navarrete, Cesar C.

    2012-01-01

    While the potential of social networking sites to contribute to educational endeavors is highlighted by researchers and practitioners alike, empirical evidence on the use of such sites for formal online learning is scant. To fill this gap in the literature, we present a case study of learners' perspectives and experiences in an online course…

  13. The effects of data-driven learning activities on EFL learners' writing development.

    PubMed

    Luo, Qinqin

    2016-01-01

    Data-driven learning has been proved as an effective approach in helping learners solve various writing problems such as correcting lexical or grammatical errors, improving the use of collocations and generating ideas in writing, etc. This article reports on an empirical study in which data-driven learning was accomplished with the assistance of the user-friendly BNCweb, and presents the evaluation of the outcome by comparing the effectiveness of BNCweb and a search engine Baidu which is most commonly used as reference resource by Chinese learners of English as a foreign language. The quantitative results about 48 Chinese college students revealed that the experimental group which used BNCweb performed significantly better in the post-test in terms of writing fluency and accuracy, as compared with the control group which used the search engine Baidu. However, no significant difference was found between the two groups in terms of writing complexity. The qualitative results about the interview revealed that learners generally showed a positive attitude toward the use of BNCweb but there were still some problems of using corpora in the writing process, thus the combined use of corpora and other types of reference resource was suggested as a possible way to counter the potential barriers for Chinese learners of English. PMID:27536538

  14. Activities for Challenging Gifted Learners by Increasing Complexity in the Common Core

    ERIC Educational Resources Information Center

    McKeone, Alyssa; Caruso, Lenora; Bettle, Kailyn; Chase, Ashley; Bryson, Bridget; Schneider, Jean S.; Rule, Audrey C.

    2015-01-01

    Gifted learners need opportunities for critical and creative thinking to stretch their minds and imaginations. Strategies for increasing complexity in the four core areas of language arts, mathematics, science, and social studies were addressed using the Common Core and Iowa Core Standards through several methods. Descriptive adjective object…

  15. Mathematics Learning with Multiple Solution Methods: Effects of Types of Solutions and Learners' Activity

    ERIC Educational Resources Information Center

    Große, Cornelia S.

    2014-01-01

    It is commonly suggested to mathematics teachers to present learners different methods in order to solve one problem. This so-called "learning with multiple solution methods" is also recommended from a psychological point of view. However, existing research leaves many questions unanswered, particularly concerning the effects of…

  16. Using Netbooks to Support Mobile Learners' Investigations across Activities and Places

    ERIC Educational Resources Information Center

    Gaved, Mark; Collins, Trevor; Mulholland, Paul; Kerawalla, Lucinda; Jones, Ann; Scanlon, Eileen; Littleton, Karen; Blake, Canan; Petrou, Marilena; Clough, Gill; Twiner, Alison

    2010-01-01

    We explore how small-format laptops ("netbooks") have been used within evidence-based investigations undertaken by secondary school students, to what extent these are suitable for effectively supporting learners across different locations and contexts, and their implications for open learning. Over the course of seven trials with 300 students and…

  17. Developmental Coordination Disorder, Gender, and Body Weight: Examining the Impact of Participation in Active Play

    ERIC Educational Resources Information Center

    Cairney, John; Kwan, Matthew Y. W.; Hay, John A.; Faught, Brent E.

    2012-01-01

    Background: To examine whether differences in participation in active play (PAP) can account for gender differences in the relationship between Developmental Coordination Disorder (DCD) and body weight/fat (BMI and percentage fat) in youth. Methods: A cross-sectional investigation of students in grades four through eight (n = 590). Height, weight…

  18. Children's Active Free Play in Local Neighborhoods: A Behavioral Mapping Study

    ERIC Educational Resources Information Center

    Veitch, J.; Salmon, J.; Ball, K.

    2008-01-01

    Many Australian children are more sedentary than they should be, and almost one in five are currently overweight or obese. Some children may face difficulties finding opportunities to be active, having poor access to safe public open spaces or having low independent mobility limiting their access to places to play. This study aimed to examine…

  19. Sports Game Play: A Comparison of Moderate to Vigorous Physical Activities in Adolescents

    ERIC Educational Resources Information Center

    Patience, Marcia A.; Kilpatrick, Marcus W.; Sun, Haichun; Flory, Sara B.; Watterson, Thomas A.

    2013-01-01

    Background: Research suggests participation in sports is an important contributor to overall adolescent physical activity (PA). Sports play has become increasingly important in physical education (PE) classes as a means for promoting healthful and enjoyable PA. Research is needed that investigates physiological and perceptual responses to sport…

  20. Video game play, child diet, and physical activity behavior change: A randomized clinical trial

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Video games designed to promote behavior change are a promising venue to enable children to learn healthier behaviors. The purpose is to evaluate the outcome from playing "Escape from Diab" (Diab) and "Nanoswarm: Invasion from Inner Space" (Nano) video games on children's diet, physical activity, an...

  1. Association of Active Play-Related Parenting Behaviors, Orientations, and Practices with Preschool Sedentary Behavior

    ERIC Educational Resources Information Center

    Loprinzi, Paul D.; Cardinal, Bradley J.; Kane, Christy; Lee, Hyo; Beets, Michael W.

    2014-01-01

    Background: Parents' behaviors, practices, beliefs, and attitudes greatly influence children's active play behavior; however, little research has examined these parental influences on preschool children's sedentary behavior (SB). Purpose: The purpose of this study was to examine the association between parental influences on…

  2. Constructive Play: Building Symbolic Competence through Physical Activity and Social Interaction.

    ERIC Educational Resources Information Center

    Fennel, Linda

    Whether physical activity and verbal communication would affect kindergarten students' scores on the Metropolitan Readiness Tests (MRT) was investigated. Twenty subjects were administered Level I of the MRT when they entered kindergarten. For 5 days per week for 4 weeks, the 10 subjects in the experimental group worked at constructive play tasks…

  3. Development of Activity, Conventional Play, and Vocalization in Infants and Preschoolers.

    ERIC Educational Resources Information Center

    Routh, Donald K.; Padan-Belkin, Efrat

    This study was designed to provide observations of the vocalizations and language of infants and young children and of changes in the subjects' pattern of play with toys, as well as their locomotor activity in a playroom. One hundred infants and children ranging from 10 months to five years of age were observed for two 15-minute periods, one with…

  4. Developing Adolescents' Resistance to Sexual Coercion through Role-Playing Activities in a Virtual World

    ERIC Educational Resources Information Center

    McGinn, Marion; Arnedillo-Sánchez, Inmaculada

    2015-01-01

    This paper explores the use of a three dimensional virtual world (3-DVW) to delivery assertiveness training to young adolescents. The case study aims to understand how a sense of presence in VWs facilitates and affect the performance of students role-playing activities to enhance their ability to resist sexual coercion. The results indicate that a…

  5. The Play Curricular Activity Reflection Discussion Model for Game-Based Learning

    ERIC Educational Resources Information Center

    Foster, Aroutis; Shah, Mamta

    2015-01-01

    This article elucidates the process of game-based learning in classrooms through the use of the Play Curricular activity Reflection Discussion (PCaRD) model. A mixed-methods study was conducted at a high school to implement three games with the PCaRD model in a year-long elective course. Data sources included interviews and observations for…

  6. Active Lessons for Active Brains: Teaching Boys and Other Experiential Learners, Grades 3-10

    ERIC Educational Resources Information Center

    James, Abigail Norfleet; Allison, Sandra Boyd; McKenzie, Caitlin Zimmerman

    2011-01-01

    If you're tired of repeating yourself to students who aren't listening, try a little less talk and a lot more action. The authors follow the best-selling "Teaching the Male Brain and Teaching the Female Brain" with this ready-to-use collection of mathematics, language arts, science, and classroom management strategies. Designed for active,…

  7. Can exergames impart health messages? Game play, framing, and drivers of physical activity among children.

    PubMed

    Lwin, May O; Malik, Shelly

    2014-01-01

    This study examines the effectiveness of incorporating exergaming into physical education lessons as a platform for imparting health education messages and influencing children's beliefs about and attitudes toward physical activity. The authors launched a 6-week intervention program using Nintendo Wii games coupled with protection motivation theory-based health messaging among 5th-grade school children in Singapore. Results indicated that when children who were exposed to threat-framed messages played Wii exergames during physical education lessons, they reported more positive physical activity attitude, self-efficacy, and perceived behavioral control than did those who underwent regular physical education lessons and were exposed to the same message. In addition, among children playing Wii, the threat and coping frames had similar effects on the degree of message influence on physical activity attitudes and beliefs. The implications for schools, parents, and health policy are discussed. PMID:24191779

  8. Motivation and Interlanguage Pragmatics in Iranian English Language Learners

    ERIC Educational Resources Information Center

    Khorshidi, Hassan Rasouli; Nimchahi, Abdolreza Bagherzadeh

    2013-01-01

    It is generally believed that interlanguage pragmatics and motivation play important roles in learning. Motivation is important because it determines the extent of the learner's active involvement and attitude toward learning. The major purpose of this study was to investigate the impact of integrative and instrumental motivation on the…

  9. Playing Active Video Games may not develop movement skills: An intervention trial

    PubMed Central

    Barnett, Lisa M.; Ridgers, Nicola D.; Reynolds, John; Hanna, Lisa; Salmon, Jo

    2015-01-01

    Background: To investigate the impact of playing sports Active Video Games on children's actual and perceived object control skills. Methods: Intervention children played Active Video Games for 6 weeks (1 h/week) in 2012. The Test of Gross Motor Development-2 assessed object control skill. The Pictorial Scale of Perceived Movement Skill Competence assessed perceived object control skill. Repeated measurements of object control and perceived object control were analysed for the whole sample, using linear mixed models, which included fixed effects for group (intervention or control) and time (pre and post) and their interaction. The first model adjusted for sex only and the second model also adjusted for age, and prior ball sports experience (yes/no). Seven mixed-gender focus discussions were conducted with intervention children after programme completion. Results: Ninety-five Australian children (55% girls; 43% intervention group) aged 4 to 8 years (M 6.2, SD 0.95) participated. Object control skill improved over time (p = 0.006) but there was no significant difference (p = 0.913) between groups in improvement (predicted means: control 31.80 to 33.53, SED = 0.748; intervention 30.33 to 31.83, SED = 0.835). A similar result held for the second model. Similarly the intervention did not change perceived object control in Model 1 (predicted means: control: 19.08 to 18.68, SED = 0.362; intervention 18.67 to 18.88, SED = 0.406) or Model 2. Children found the intervention enjoyable, but most did not perceive direct equivalence between Active Video Games and ‘real life’ activities. Conclusions: Whilst Active Video Game play may help introduce children to sport, this amount of time playing is unlikely to build skill. PMID:26844136

  10. Physical Activity and Play Behaviours in Children and Young People with Intellectual Disabilities: A Cross-Sectional Observational Study

    ERIC Educational Resources Information Center

    Boddy, Lynne M.; Downs, Samantha J.; Knowles, Zoe R.; Fairclough, Stuart J.

    2015-01-01

    The benefits of physical activity and active play for children and young people are well established. However, there is a lack of physical activity research involving children and young people with intellectual disabilities. This study investigated habitual physical activity and recess play behaviour in 70 5- to 15-year-old participants with…

  11. Learner Agency in Language Learning: The Story of a Distance Learner of EFL in China

    ERIC Educational Resources Information Center

    Xiao, Junhong

    2014-01-01

    Learner agency plays a key role in self-regulated learning. Yet, there is a paucity of research into its role in the distance learning context. Using reflective narratives written by a distance learner of English in China, this longitudinal case study aims to investigate the ways in which learner agency mediates the language learning in the…

  12. Assessment of active play, inactivity and perceived barriers in an inner city neighborhood.

    PubMed

    Kottyan, Gregg; Kottyan, Leah; Edwards, Nicholas M; Unaka, Ndidi I

    2014-06-01

    Avondale, a disadvantaged neighborhood in Cincinnati, lags behind on a number of indicators of child well-being. Childhood obesity has become increasingly prevalent, as one-third of Avondale's kindergarteners are obese or overweight. The study objective was to determine perceptions of the quantity of and obstacles to childhood physical activity in the Avondale community. Caregivers of children from two elementary schools were surveyed to assess their child's physical activity and barriers to being active. Three hundred and forty surveys were returned out of 1,047 for a response rate of 32%. On school days, 41% of caregivers reported that their children spent more than 2 h watching television, playing video games, or spending time on the computer. While over half of respondents reported that their children get more than 2 h of physical activity on school days, 14% of children were reported to be physically active less than 1 h per day. Caregivers identified violence, cost of extracurricular activities, and lack of organized activities as barriers to their child's physical activity. The overwhelming majority of caregivers expressed interest in a program to make local playgrounds safer. In conclusion, children in Avondale are not participating in enough physical activity and are exposed to more screen time than is recommended by the AAP. Safety concerns were identified as a critical barrier to address in future advocacy efforts in this community. This project represents an important step toward increasing the physical activity of children in Avondale and engaging the local community. PMID:24306236

  13. Activity-Dependent Calpain Activation Plays a Critical Role in Synaptic Facilitation and Post-Tetanic Potentiation

    ERIC Educational Resources Information Center

    Khoutorsky, Arkady; Spira, Micha E.

    2009-01-01

    Synaptic facilitation and post-tetanic potentiation (PTP) are believed to necessitate active regeneration of the release machinery and supply of synaptic vesicles to a ready-releasable site. The prevailing hypothesis assumes that synapsins play pivotal roles in these processes. Using a cholinergic synapse formed between cultured "Aplysia" neurons…

  14. Using analogy role-play activity in an undergraduate biology classroom to show central dogma revision.

    PubMed

    Takemura, Masaharu; Kurabayashi, Mario

    2014-01-01

    For the study of biology in an undergraduate classroom, a classroom exercise was developed: an analogy role-play to learn mechanisms of gene transcription and protein translation (central dogma). To develop the central dogma role-play exercise, we made DNA and mRNA using paper sheets, tRNA using a wire dress hanger, and amino acids using Lego® blocks (Lego System A/S, Denmark). Students were studying in the course of mathematics, physics, or chemistry, so biology was not among their usual studies. In this exercise, students perform the central dogma role-play and respectively act out nuclear matrix proteins, a transcription factor, an RNA polymerase II, an mRNA transport protein, nuclear pore proteins, a large ribosomal subunit, a small ribosomal subunit, and several amino-acyl tRNA synthetases. Questionnaire results obtained after the activity show that this central dogma role-play analogy holds student interest in the practical molecular biological processes of transcription and translation. PMID:24898113

  15. Technical activity profile and influence of body anthropometry on playing performance in female elite team handball.

    PubMed

    Michalsik, Lars B; Aagaard, Per; Madsen, Klavs

    2015-04-01

    To determine the physical demands placed on female elite team handball (TH) players in relation to playing position and body anthropometry, female elite TH primarily field players were monitored during match-play using video recording and subsequent computerized technical match analysis during 5 regular tournament match seasons. Technical match activities were distributed in 6 major types of playing actions (shots, breakthroughs, fast breaks, technical errors, defensive errors, and tackles) and further divided into various subcategories (e.g., type of shot, hard or light tackles, claspings, screenings, and blockings). Furthermore, anthropometric measurements were performed. Each player had 28.3 ± 11.0 (group means ± SD) high-intense playing actions per match with a total effective playing time of 50.70 ± 5.83 minutes. On average, each player made 2.8 ± 2.6 fast breaks, gave 7.9 ± 14.4 screenings, received 14.6 ± 9.2 tackles in total, and performed 7.7 ± 3.7 shots while in offense, along with 3.5 ± 3.8 blockings, 1.9 ± 2.7 claspings, and 6.2 ± 3.8 hard tackles in defense. Mean body height, body mass, and age in the Danish Premier Female Team Handball League were 175.4 ± 6.1 cm, 69.5 ± 6.5 kg, and 25.4 ± 3.7 years, respectively. Wing players were lighter (63.5 ± 4.8 kg, p < 0.001) and smaller (169.3 ± 4.9 cm, p < 0.001) than backcourt players (BP) (70.6 ± 5.3 kg, 177.0 ± 5.4 cm) and pivots (PV) (72.5 ± 4.9 kg, 177.7 ± 4.9 cm). In conclusion, the present match observations revealed that female elite TH players during competitive games intermittently perform a high number of short-term, high-intense technical playing actions making modern female elite TH a physically demanding team sport. No sign of technical fatigue were observed, since the amount of intense technical playing actions remained unchanged in the second half. Marked positional differences in the physical demands were demonstrated, with wing players performing more fast breaks and less

  16. Latino Mothers in Farmworker Families’ Beliefs about Preschool Children’s Physical Activity and Play

    PubMed Central

    Grzywacz, Joseph G.; Arcury, Thomas A.; Trejo, Grisel; Quandt, Sara A.

    2014-01-01

    Objective Document beliefs about the contribution of physical activity to preschool-aged children’s health held by Latino mothers in farmworker families, and delineate their perceived barriers or constraints that impose limits on preschool-aged children’s physical activity. Method Qualitative data obtained through semi-structured in-depth interviews (N=33) with mothers of preschool-aged children living in Latino farmworker families in North Carolina. Results Mothers universally agree that regular vigorous physical activity is good for preschool-aged children’s health, including obesity prevention. However, excessive physical activity can produce illnesses, as well as other physical and emotional problems, and should be limited. Mothers wanted their children to engage in more sedentary forms of activity because they believed it would benefit learning. Physical and chemical hazards in rural environments, distance to parks and play spaces, and lack of familiarity and concerns about neighbors constrained children’s physical activity. Conclusions Although physical activity is believed to be beneficial, strong cultural beliefs and real contextual barriers undermine preschool-aged Latino farmworker children’s level of physical activity. PMID:24522435

  17. p21 induction plays a dual role in anti-cancer activity of ursolic acid.

    PubMed

    Zhang, Xudong; Song, Xinhua; Yin, Shutao; Zhao, Chong; Fan, Lihong; Hu, Hongbo

    2016-03-01

    Previous studies have shown that induction of G1 arrest and apoptosis by ursolic acid is associated with up-regulation of cyclin-dependent kinase inhibitor (CDKI) protein p21 in multiple types of cancer cells. However, the functional role of p21 induction in G1 cell cycle arrest and apoptosis, and the mechanisms of p21 induction by ursolic acid have not been critically addressed. In the current study, we demonstrated that p21 played a mediator role in G1 cell cycle arrest by ursolic acid, whereas p21-mediated up-regulation of Mcl-1 compromised apoptotic effect of ursolic acid. These results suggest that p21 induction plays a dual role in the anti-cancer activity of ursolic acid in terms of cell cycle and apoptosis regulation. p21 induction by ursolic acid was attributed to p53 transcriptional activation. Moreover, we found that ursolic acid was able to inhibit murine double minute-2 protein (MDM2) and T-LAK cell-originated protein kinase (TOPK), the two negative regulator of p53, which in turn contributed to ursolic acid-induced p53 activation. Our findings provided novel insights into understanding of the mechanisms involved in cell cycle arrest and apoptosis induction in response to ursolic acid exposure. PMID:26582056

  18. Day Length and Weather Effects on Children’s Physical Activity and Participation in Play, Sports, and Active Travel

    PubMed Central

    Goodman, Anna; Paskins, James; Mackett, Roger

    2013-01-01

    Background Children in primary school are more physically active in the spring/summer. Little is known about the relative contributions of day length and weather, however, or about the underlying behavioral mediators. Methods 325 British children aged 8 to 11 wore accelerometers as an objective measure of physical activity, measured in terms of mean activity counts. Children simultaneously completed diaries in which we identified episodes of out-of-home play, structured sports, and active travel. Our main exposure measures were day length, temperature, rainfall, cloud cover, and wind speed. Results Overall physical activity was higher on long days (≥ 14 hours daylight), but there was no difference between short (< 9.5 hours) and medium days (10.2–12.6 hours). The effect of long day length was largest between 5 PM and 8 PM, and persisted after adjusting for rainfall, cloud cover, and wind. Up to half this effect was explained by a greater duration and intensity of out-of-home play on long days; structured sports and active travel were less affected by day length. Conclusions At least above a certain threshold, longer afternoon/evening daylight may have a causal role in increasing child physical activity. This strengthens the public health arguments for daylight saving measures such as those recently under consideration in Britain. PMID:22826506

  19. Developing Pharmacy Student Communication Skills through Role-Playing and Active Learning

    PubMed Central

    Zeszotarski, Paula; Ma, Carolyn

    2015-01-01

    Objective. To evaluate the impact on pharmacy students of a communication course, which used role-playing to develop active-learning skills. Design. Students role-playing pharmacists in patient care scenarios were critiqued by students and pharmacist faculty members. Grading was performed using the rubric inspired by Bruce Berger’s Communication Skills for Pharmacists. Written skills were evaluated using student written critique questionnaires. Students completed precourse and postcourse self-assessment surveys. Preceptor evaluations were analyzed for course impact. Assessment. Students demonstrated improvement in oral skills based on role-play scores (45.87/50) after practice sessions. The average score based on the student questionnaire was 9.31/10. Gain was demonstrated in all defined course objectives. Impact on introductory pharmacy practice experience (IPPE) communication objectives was insignificant. Student evaluations for course and teaching strategy reflected a high average. Conclusion. Study results demonstrated improvement in oral and written communication skills that may help improve interprofessional teamwork between pharmacists and other health care providers. PMID:25995519

  20. Using What Learners Know.

    ERIC Educational Resources Information Center

    Burns, Mary; Adams, Sharon

    2000-01-01

    This issue of "TAP into Learning" focuses on technology-assisted learning activities for students, in particular on those that use spreadsheets. Articles include: "Using What Learners Know"; "Activity: Grade 7 and 8 Math, Social Studies and Language Arts"; "Managing Growth: Collaborative Decision-Making in Urban Planning"; "Spreadsheets"; "Getting…

  1. Participatory Multimedia Learning: Engaging Learners

    ERIC Educational Resources Information Center

    Kiili, Kristian

    2005-01-01

    The purpose of this paper is to present a participatory multimedia learning model for use in designing multimedia learning environments that support an active learning process, creative participation, and learner engagement. Participatory multimedia learning can be defined as learning with systems that enable learners to produce part of the…

  2. Arf6 plays an early role in platelet activation by collagen and convulxin.

    PubMed

    Choi, Wangsun; Karim, Zubair A; Whiteheart, Sidney W

    2006-04-15

    Small GTPases play critical roles in hemostasis, though the roster of such molecules in platelets is not complete. In this study, we report the presence of Ras-related GTPases of the ADP-ribosylation factor (Arf) family. Platelets contain Arf1 or 3 and Arf6, with the latter being predominantly membrane associated. Using effector domain pull-down assays, we show, counter to other GTPases, that Arf6-GTP is present in resting platelets and decreases rapidly upon activation with collagen or convulxin. This decrease does not completely rely on secondary agonists (ADP and thromboxane A2) or require integrin signaling. The decrease in free Arf6-GTP temporally precedes activation of Rho family GTPases (RhoA, Cdc42, and Rac1). Using a membrane-permeant, myristoylated peptide, which mimics the N-terminus of Arf6, we show that the Arf6-GTP decrease is essential for collagen- and convulxin-induced aggregation, platelet adherence, and spreading on collagen-coated glass. Treatment with this peptide also affects the activation of Rho family GTPases, but has little effect on RalA and Rap1 or on agonist-induced calcium mobilization. These data show that Arf6 is a key element in activation through GPVI, and is required for activation of the Rho family GTPases and the subsequent cytoskeletal rearrangements needed for full platelet function. PMID:16352809

  3. Energy Expenditure and Intensity of Physical Activity in Soccer Referees During Match-Play

    PubMed Central

    da Silva, Alberto Inácio; Fernandes, Luiz Cláudio; Fernandez, Ricardo

    2008-01-01

    The aim of this study was to determine the caloric expenditure and the intensity of physical activities performed by official soccer referees during a match expressed in Metabolic Equivalent (METs). The physical activity of referees accredited by CBF (Brazilian Confederation of Soccer) was video-recorded during twenty-nine official games of Paraná Championship (Brasil), Series A and B of the 2005/2006. Computerized video analysis was used to determine the time spent in 6 locomotor activities (standing still, walking, jogging, backwards running, running and sprint). The frequency and duration of each activity were recorded and these data were utilized to calculate the distance covered by the referee. Energy expenditure values were estimated, utilizing specific equations, from the time players spent in each motor activity. The referees observed in this study had a mean age of 38.9 ± 3.8 years, body mass of 86.1 ± 7.1 kg, stature of 1.80 ± 0.07 m and a body mass index of 26.5 ± 0.6 kg·m-2. During match-play, referees covered an average distance of 9155.4 ± 70.3 meters (8411 - 9765), with a mean energy expenditure of 734.7 ± 65 kcal. This energy expenditure was significantly reduced in the second half: 359.9 ± 6.3 vs 374.7 ± 6.6 kcal (p = 0.006), and averaged to be moderate energy intensity (5 METs) with predominant utilization of the aerobic energy system. In total, during 67% of match-play the intensity was equal or lower than 3.8 METs and in 33% it was higher than 9.8 METs. The pattern of movement observed in the present study confirms that soccer refereeing may be considered as a highly intermittent exercise mode. The high to low-intensity activity ratio may be defined as 1:7.1. In conclusion, referees officiating in professional soccer matches in Brazil should perform a physical conditioning regime that provides the stamina required at this level and consume appropriate and adequate nutrition to meet the energetic demands for match-play. Key points

  4. The Use of Linked Activity Schedules to Teach Children with Autism to Play Hide-and-Seek

    ERIC Educational Resources Information Center

    Brodhead, Matthew T.; Higbee, Thomas S.; Pollard, Joy S.; Akers, Jessica S.; Gerencser, Kristina R.

    2014-01-01

    Linked activity schedules were used to establish appropriate game play in children with autism during a game of hide-and-seek. All 6 participants demonstrated acquisition of appropriate play skills in the presence of the activity schedules and maintained responding during subsequent phases. When the schedules were removed, responding decreased to…

  5. Where to Next for School Playground Interventions to Encourage Active Play? An Exploration of Structured and Unstructured School Playground Strategies

    ERIC Educational Resources Information Center

    Hyndman, Brendon

    2015-01-01

    An emerging public health priority is to enhance children's opportunities for active play. Children spend a large proportion of weekdays in schools, making schools an influential and suitable setting to promote children's active play. Rather than continually increasing the burdens placed upon busy teaching staff, the use of school playground…

  6. The Development and Evaluation of an Achievement Test for Measuring the Efficacy of Task-Based Writing Activities to Enhance Iranian EFL Learners' Reading Comprehension

    ERIC Educational Resources Information Center

    Nejad, Ferdows Mohsen; Khosravian, Fereshteh

    2014-01-01

    The present study examined the reliability of an achievement test to measure the efficacy of task-based writing activities to improve Iranian EFL learners' reading comprehension at the intermediate level in a private language institute in Ilam, Iran, namely Alefba language institute. To achieve the goal, the techniques for evaluating reliability…

  7. Effects of an Online Learning Community on Active and Reflective Learners' Learning Performance and Attitudes in a Face-to-Face Undergraduate Course

    ERIC Educational Resources Information Center

    Zhan, Zehui; Xu, Fuyin; Ye, Huiwen

    2011-01-01

    The purpose of this study was to examine the effects of an Online Learning Community (OLC) on active and reflective learners' learning performance and attitude in a face-to-face undergraduate digital design course. 814 freshmen in an introductory digital design course were randomly assigned to one of two treatments: one offered students an OLC,…

  8. The Effects of Pragmatic Consciousness-Raising Activities on the Development of Pragmatic Awareness and Use of Hearsay Evidential Markers for Learners of Japanese as a Foreign Language

    ERIC Educational Resources Information Center

    Narita, Ritsuko

    2009-01-01

    The present study investigates the effectiveness of pragmatic consciousness-raising (PCR) activities in the L2 pragmatic acquisition of hearsay evidential markers by learners of Japanese as a foreign language (JFL). PCR is essentially an inductive approach to facilitating awareness of how language forms are used appropriately in a given context.…

  9. Pretend play.

    PubMed

    Weisberg, Deena Skolnick

    2015-01-01

    Pretend play is a form of playful behavior that involves nonliteral action. Although on the surface this activity appears to be merely for fun, recent research has discovered that children's pretend play has connections to important cognitive and social skills, such as symbolic thinking, theory of mind, and counterfactual reasoning. The current article first defines pretend play and then reviews the arguments and evidence for these three connections. Pretend play has a nonliteral correspondence to reality, hence pretending may provide children with practice with navigating symbolic relationships, which may strengthen their language skills. Pretend play and theory of mind reasoning share a focus on others' mental states in order to correctly interpret their behavior, hence pretending and theory of mind may be mutually supportive in development. Pretend play and counterfactual reasoning both involve representing nonreal states of affairs, hence pretending may facilitate children's counterfactual abilities. These connections make pretend play an important phenomenon in cognitive science: Studying children's pretend play can provide insight into these other abilities and their developmental trajectories, and thereby into human cognitive architecture and its development. PMID:26263228

  10. Proteasome activators, PA28γ and PA200, play indispensable roles in male fertility

    PubMed Central

    Huang, Lin; Haratake, Kousuke; Miyahara, Hatsumi; Chiba, Tomoki

    2016-01-01

    Protein degradation mediated by the proteasome is important for the protein homeostasis. Various proteasome activators, such as PA28 and PA200, regulate the proteasome function. Here we show double knockout (dKO) mice of Psme3 and Psme4 (genes for PA28γ and PA200), but not each single knockout mice, are completely infertile in male. The dKO sperms exhibited remarkable defects in motility, although most of them showed normal appearance in morphology. The proteasome activity of the mutant sperms decreased notably, and the sperms were strongly positive with ubiquitin staining. Quantitative analyses of proteins expressed in dKO sperms revealed up-regulation of several proteins involved in oxidative stress response. Furthermore, increased 8-OHdG staining was observed in dKO sperms head, suggesting defective response to oxidative damage. This report verified PA28γ and PA200 play indispensable roles in male fertility, and provides a novel insight into the role of proteasome activators in antioxidant response. PMID:27003159

  11. Reaching English Language Learners

    ERIC Educational Resources Information Center

    Keenan, Suzanne

    2004-01-01

    In the authors' science classroom, students who are English Language Learners (ELL) seem to struggle less than they do with other content areas. She believes the "handson" nature of science motivates and encourages students to interact with others. This interaction spurs conversation among the students involved in the activity. If a child is…

  12. Parental encouragement is positively associated with outdoor active play outside of school hours among 7-12 year olds.

    PubMed

    Ferrao, Thomas; Janssen, Ian

    2015-01-01

    Background. Physical activity is important for children's physical, mental, and social well-being. Outdoor active play is an important yet unstudied domain of children's physical activity. The objective of this study was to determine if parental encouragement is associated with the frequency that children engage in outdoor active play outside of school hours. Methods. Participants consisted of 514 children aged 7-12 years and one of their parents. Parents completed a survey that included four questions that assessed how frequently they used verbal cues to encourage their child to play outdoors. Points were assigned to each response and averaged across the 4 questions, and based on this average participants were assigned to quintiles. The survey included seven questions that asked parents to assess how frequently their child played outdoors outside of school hours. Points were assigned to each response and summed to create an active outdoor play frequency score. General linear models assessed associations between parental encouragement and outdoor play while controlling for individual, family, and neighborhood covariates. Results. The mean outdoor active play frequency score increased significantly across quintiles of the parental encouragement score as follows: 6.0 (standard error = 0.7) in quintile 1, 9.8 (0.6) in quintile 2, 11.4 (0.6) in quintile 3, 16.2 (0.9) in quintile 4, and 23.3 (1.3) in quintile 5. After adjusting for covariates, the mean outdoor active play frequency score was almost three times higher in the highest parental encouragement quintile than in the lowest quintile (20.4 vs. 7.8). Conclusions. Parents use of verbal cues to encourage their children to play outdoors was independently associated with outdoor active play among 7-12 year olds. PMID:26644990

  13. Parental encouragement is positively associated with outdoor active play outside of school hours among 7–12 year olds

    PubMed Central

    Ferrao, Thomas

    2015-01-01

    Background. Physical activity is important for children’s physical, mental, and social well-being. Outdoor active play is an important yet unstudied domain of children’s physical activity. The objective of this study was to determine if parental encouragement is associated with the frequency that children engage in outdoor active play outside of school hours. Methods. Participants consisted of 514 children aged 7–12 years and one of their parents. Parents completed a survey that included four questions that assessed how frequently they used verbal cues to encourage their child to play outdoors. Points were assigned to each response and averaged across the 4 questions, and based on this average participants were assigned to quintiles. The survey included seven questions that asked parents to assess how frequently their child played outdoors outside of school hours. Points were assigned to each response and summed to create an active outdoor play frequency score. General linear models assessed associations between parental encouragement and outdoor play while controlling for individual, family, and neighborhood covariates. Results. The mean outdoor active play frequency score increased significantly across quintiles of the parental encouragement score as follows: 6.0 (standard error = 0.7) in quintile 1, 9.8 (0.6) in quintile 2, 11.4 (0.6) in quintile 3, 16.2 (0.9) in quintile 4, and 23.3 (1.3) in quintile 5. After adjusting for covariates, the mean outdoor active play frequency score was almost three times higher in the highest parental encouragement quintile than in the lowest quintile (20.4 vs. 7.8). Conclusions. Parents use of verbal cues to encourage their children to play outdoors was independently associated with outdoor active play among 7–12 year olds. PMID:26644990

  14. "Dealing With" Unexpected Learner Contributions in Whole Group Activities: An Examination of Novice Language Teacher Discursive Practices

    ERIC Educational Resources Information Center

    Fagan, Drew S.

    2012-01-01

    The current paper examines the discursive practices of one novice English as a Second Language (ESL) teacher "dealing with" learners' unexpected contributions in whole group classroom interactions during teacher- and learner-initiated sequences-of-talk. The study draws from two fields of research: classroom discourse studies…

  15. Relation between Children's Attachment to Kindergarten Teachers, Personality Characteristics and Play Activities

    ERIC Educational Resources Information Center

    Cugmas, Zlatka

    2011-01-01

    The purpose of this study was to develop the "observational scheme of child's free play in kindergarten" (OFP) and examine the associations between "child's attachment to his/her kindergarten teacher" (CAKT) and: (1) cognitive and social play behaviour, (2) child's contacts with his/her peers and teacher during free play session in kindergarten,…

  16. Rho-kinase activation in leukocytes plays a pivotal role in myocardial ischemia/reperfusion injury.

    PubMed

    Kitano, Katsunori; Usui, Soichiro; Ootsuji, Hiroshi; Takashima, Shin-ichiro; Kobayashi, Daisuke; Murai, Hisayoshi; Furusho, Hiroshi; Nomura, Ayano; Kaneko, Shuichi; Takamura, Masayuki

    2014-01-01

    The Rho/Rho-kinase pathway plays an important role in many cardiovascular diseases such as hypertension, atherosclerosis, heart failure, and myocardial infarction. Although previous studies have shown that Rho-kinase inhibitors reduce ischemia/reperfusion (I/R) injury and cytokine production, the role of Rho-kinase in leukocytes during I/R injury is not well understood. Mice were subjected to 30-min ischemia and reperfusion. Rho-kinase activity was significantly greater in leukocytes subjected to myocardial I/R compared to the sham-operated mice. Administration of fasudil, a Rho-kinase inhibitor, significantly reduced the I/R-induced expression of the proinflammatory cytokines interleukin (IL)-6, C-C motif chemoattractant ligand 2 (CCL2), and tumor necrosis factor (TNF)-α, in leukocytes, compared with saline as the vehicle. Furthermore, fasudil decreased I/R-induced myocardial infarction/area at risk (IA) and I/R-induced leukocyte infiltration in the myocardium. Interestingly, IA in fasudil-administered mice with leukocyte depletion was similar to that in fasudil-administered mice. I/R also resulted in remarkable increases in the mRNA expression levels of the proinflammatory cytokines TNF-α, IL-6, and CCL2 in the heart. Inhibition of Rho-kinase activation in leukocytes has an important role in fasudil-induced cardioprotective effects. Hence, inhibition of Rho-kinase may be an additional therapeutic intervention for the treatment of acute coronary syndrome. PMID:24638037

  17. Rho-Kinase Activation in Leukocytes Plays a Pivotal Role in Myocardial Ischemia/Reperfusion Injury

    PubMed Central

    Kitano, Katsunori; Usui, Soichiro; Ootsuji, Hiroshi; Takashima, Shin-ichiro; Kobayashi, Daisuke; Murai, Hisayoshi; Furusho, Hiroshi; Nomura, Ayano; Kaneko, Shuichi; Takamura, Masayuki

    2014-01-01

    The Rho/Rho-kinase pathway plays an important role in many cardiovascular diseases such as hypertension, atherosclerosis, heart failure, and myocardial infarction. Although previous studies have shown that Rho-kinase inhibitors reduce ischemia/reperfusion (I/R) injury and cytokine production, the role of Rho-kinase in leukocytes during I/R injury is not well understood. Mice were subjected to 30-min ischemia and reperfusion. Rho-kinase activity was significantly greater in leukocytes subjected to myocardial I/R compared to the sham-operated mice. Administration of fasudil, a Rho-kinase inhibitor, significantly reduced the I/R-induced expression of the proinflammatory cytokines interleukin (IL)-6, C-C motif chemoattractant ligand 2 (CCL2), and tumor necrosis factor (TNF)-α, in leukocytes, compared with saline as the vehicle. Furthermore, fasudil decreased I/R-induced myocardial infarction/area at risk (IA) and I/R-induced leukocyte infiltration in the myocardium. Interestingly, IA in fasudil-administered mice with leukocyte depletion was similar to that in fasudil-administered mice. I/R also resulted in remarkable increases in the mRNA expression levels of the proinflammatory cytokines TNF-α, IL-6, and CCL2 in the heart. Inhibition of Rho-kinase activation in leukocytes has an important role in fasudil-induced cardioprotective effects. Hence, inhibition of Rho-kinase may be an additional therapeutic intervention for the treatment of acute coronary syndrome. PMID:24638037

  18. RABEX-5 plays an oncogenic role in breast cancer by activating MMP-9 pathway

    PubMed Central

    2013-01-01

    Background RABEX-5, a guanine nucleotide exchange factor (GEF) for RAB-5, plays an important role in cell mobility and altered expression associated with tumor metastasis. This study aimed to investigate the role of RABEX-5 in proliferation and metastasis of breast cancer in vitro and ex vivo. Methods RABEX-5 expression was examined in breast cancer, benign tumor and normal breast tissues by immunohistochemistry and western blot. Two stable cell lines were established, the MCF-7/NC negative control cell line and the MCF-7/KD cell line, which stably expressed an RNA interference (RNAi) construct that induced downregulation of RABEX-5 expression. These cell lines were utilized to evaluate the role of RABEX-5 in cell proliferation and migration in vitro and tumorigenicity in vivo. The possible role of RABEX-5 in the regulation of matrix metallopeptidase 9 (MMP-9) was evaluated using western blot and real-time PCR. Results RABEX-5 expression was found to be significantly higher in breast cancer tissues compared with benign tumor and normal breast tissues. High levels of RABEX-5 expression were associated with axillary lymph node metastasis. In addition, RABEX-5 silencing significantly reduced cancer cell proliferation, colony formation and migration ability in vitro and inhibited tumor growth in vivo. RABEX −5 knockdown also attenuated the migration of breast cancer cells via modulation of MMP-9 transcriptional activity. Conclusions Our results indicate that RABEX-5 plays an oncogenic role in breast cancer by modulating the proliferation and metastasis potential of breast cancer cells. Thus, RABEX-5 is a promising prognostic indicator for patients with breast cancer. PMID:23941575

  19. Exploring Shifts in Middle School Learners' Modeling Activity While Generating Drawings, Animations, and Computational Simulations of Molecular Diffusion

    NASA Astrophysics Data System (ADS)

    Wilkerson-Jerde, Michelle H.; Gravel, Brian E.; Macrander, Christopher A.

    2015-04-01

    Modeling and using technology are two practices of particular interest to K-12 science educators. These practices are inextricably linked among professionals, who engage in modeling activity with and across a variety of representational technologies. In this paper, we explore the practices of five sixth-grade girls as they generated models of smell diffusion using drawing, stop-motion animation, and computational simulation during a multi-day workshop. We analyze video, student discourse, and artifacts to address the questions: In what ways did learners' modeling practices, reasoning about mechanism, and ideas about smell shift as they worked across this variety of representational technologies? And, what supports enabled them to persist and progress in the modeling activity? We found that the girls engaged in two distinct modeling cycles that reflected persistence and deepening engagement in the task. In the first, messing about, they focused on describing and representing many ideas related to the spread of smell at once. In the second, digging in, they focused on testing and revising specific mechanisms that underlie smell diffusion. Upon deeper analysis, we found these cycles were linked to the girls' invention of "oogtom," a representational object that encapsulated many ideas from the first cycle and allowed the girls to restart modeling with the mechanistic focus required to construct simulations. We analyze the role of activity design, facilitation, and technological infrastructure in this pattern of engagement over the course of the workshop and discuss implications for future research, curriculum design, and classroom practice.

  20. Playing in parallel: the effects of multiplayer modes in active video game on motivation and physical exertion.

    PubMed

    Peng, Wei; Crouse, Julia

    2013-06-01

    Although multiplayer modes are common among contemporary video games, the bulk of game research focuses on the single-player mode. To fill the gap in the literature, the current study investigated the effects of different multiplayer modes on enjoyment, future play motivation, and the actual physical activity intensity in an active video game. One hundred sixty-two participants participated in a one-factor between-subject laboratory experiment with three conditions: (a) single player: play against self pretest score; (b) cooperation with another player in the same physical space; (c) parallel competition with another player in separated physical spaces. We found that parallel competition in separate physical spaces was the optimal mode, since it resulted in both high enjoyment and future play motivation and high physical intensity. Implications for future research on multiplayer mode and play space as well as active video game-based physical activity interventions are discussed. PMID:23509986

  1. Kindergarten Practitioners' Experience of Promoting Children's Involvement in and Enjoyment of Physically Active Play: Does the Contagion of Physical Energy Affect Physically Active Play?

    ERIC Educational Resources Information Center

    Bjørgen, Kathrine; Svendsen, Birgit

    2015-01-01

    This research is based on interviews that explore the reflections of 10 Norwegian kindergarten practitioners with regard to the importance of their involvement in children's physically active outdoor playtime. The data were analysed from a qualitative phenomenological perspective and resulted in basic themes that describe the practitioners'…

  2. PRIDE for PLAY: Personal Responsibility in Daily Effort for Participation in Lifelong Activity for Youths. A Singaporean Context

    PubMed Central

    Chia, Michael

    2007-01-01

    Singapore, a developed city state of four million people is experiencing the pitfalls that come with rapid modernisation and economic progress- elevated disease risk factors among adults and young people. Weekly compulsory physical education classes of 70 minutes in schools and the associated sports activities after classes are inadequate to meet emergent physical activity guidelines of a daily accumulation of at least 90 minutes of physical activity of at least moderate intensity. Daily play sessions that are exclusive of an active daily recess, physical education classes taught by trained specialists and after-school sport sessions, can provide many developmental and holistic health benefits that may carry over into adulthood. A school environment that is play-encouraging, play-enabling and play-inviting can be a useful, innovative and natural way of inculcating a love for movement and help redress a serious trend of physical activity insufficiency while youngsters engage electronic gaming activities. Pilot initiatives for the PRIDE (personal responsibility in daily effort) for PLAY (participation in lifelong activity for youths) programme is a radicalised approach in a number of primary schools in Singapore to infuse daily physical play of between 20 to 45 minutes during curriculum hours. The hope is that PRIDE for PLAY will reap benefits of improved holistic health of youngsters- better physical, social, emotional and mental attributes. While PRIDE for PLAY is no panacea to all of the ills of modernisation, it will go some way in helping the students of tomorrow to be physically healthy, socially more engaged and tolerant of others, mentally more apt to problem-solve and emotionally more proficient to embrace working life in adulthood. Key pointsPhysical play is natural among young people and a daily dose of play can help young people meet daily requirements for accumulated physical activity of at least 90 minutes and at least of a moderate intensity.Play is

  3. Brain activation by an olfactory stimulus paired with juvenile play in female rats.

    PubMed

    Paredes-Ramos, P; McCarthy, M M; Bowers, J M; Miquel, M; Manzo, J; Coria-Avila, G A

    2014-06-22

    We have previously shown that reward experienced during social play at juvenile age can be paired with artificial odors, and later in adulthood facilitate olfactory conditioned partner preferences (PP) in female rats. Herein, we examined the expression of FOS immunoreactivity (FOS-IR) following exposure to the odor paired with juvenile play (CS+). Starting at day P31 females received daily 30-min periods of social play with lemon-scented (paired group) or unscented females (unpaired group). At day P42, they were tested for play-PP with two juvenile males, one bearing the CS+ (lemon) and one bearing a novel odor (almond). Females were ovariectomized, hormone-primed and at day P55 tested for sexual-PP between two adult stud males scented with lemon or almond. In both tests, females from the paired group displayed conditioned PP (play or sexual) toward males bearing the CS+. In the present experiments females were exposed at day P59 to the CS+ during 60 min and their brains processed for FOS-IR. One group of female rats (Play+Sex) underwent play-PP and sexual-PP, whereas a second group of females (Play-only) underwent exclusively play-PP but not sexual-PP. Results showed that in the Play-only experiment exposure to the CS+ induced more FOS-IR in the medial prefrontal cortex, orbitofrontal cortex, dorsal striatum, and ventral tegmental area as compared to females from the unpaired group. In the Play+Sex experiment, more FOS-IR was observed in the piriform cortex, dorsal striatum, lateral septum, nucleus accumbens shell, bed nucleus of the stria terminalis and medial amygdala as compared to females from the unpaired group. Taken together, these results indicate mesocorticolimbic brain areas direct the expectation and/or choice of conditioned partners in female rats. In addition, transferring the meaning of play to sex preference requires different brain areas. PMID:24835545

  4. Online Games for Young Learners' Foreign Language Learning

    ERIC Educational Resources Information Center

    Butler, Yuko Goto; Someya, Yuumi; Fukuhara, Eiji

    2014-01-01

    Young learners' use of instructional games in foreign language learning is not yet well understood. Using games that were part of the learning tools for an online assessment, Jido-Eiken, a standardized English proficiency test for young learners in Japan, we examined young learners' game-playing behaviours and the relationship of these…

  5. Brain Activity in Fairness Consideration during Asset Distribution: Does the Initial Ownership Play a Role?

    PubMed Central

    Wu, Yin; Hu, Jie; van Dijk, Eric; Leliveld, Marijke C.; Zhou, Xiaolin

    2012-01-01

    Previous behavioral studies have shown that initial ownership influences individuals’ fairness consideration and other-regarding behavior. However, it is not entirely clear whether initial ownership influences the brain activity when a recipient evaluates the fairness of asset distribution. In this study, we randomly assigned the bargaining property (monetary reward) to either the allocator or the recipient in the ultimatum game and let participants of the study, acting as recipients, receive either disadvantageous unequal, equal, or advantageous unequal offers from allocators while the event-related potentials (ERPs) were recorded. Behavioral results showed that participants were more likely to reject disadvantageous unequal and equal offers when they initially owned the property as compared to when they did not. The two types of unequal offers evoked more negative going ERPs (the MFN) than the equal offers in an early time window and the differences were not modulated by the initial ownership. In a late time window, however, the P300 responses to division schemes were affected not only by the type of unequal offers but also by whom the property was initially assigned to. These findings suggest that while the MFN may function as a general mechanism that evaluates whether the offer is consistent or inconsistent with the equity rule, the P300 is sensitive to top-down controlled processes, into which factors related to the allocation of attentional resources, including initial ownership and personal interests, come to play. PMID:22761850

  6. Autophagy Activated by Bluetongue Virus Infection Plays a Positive Role in Its Replication.

    PubMed

    Lv, Shuang; Xu, Qingyuan; Sun, Encheng; Yang, Tao; Li, Junping; Feng, Yufei; Zhang, Qin; Wang, Haixiu; Zhang, Jikai; Wu, Donglai

    2015-08-01

    Bluetongue virus (BTV) is an important pathogen of wild and domestic ruminants. Despite extensive study in recent decades, the interplay between BTV and host cells is not clearly understood. Autophagy as a cellular adaptive response plays a part in many viral infections. In our study, we found that BTV1 infection triggers the complete autophagic process in host cells, as demonstrated by the appearance of obvious double-membrane autophagosome-like vesicles, GFP-LC3 dots accumulation, the conversion of LC3-I to LC3-II and increased levels of autophagic flux in BSR cells (baby hamster kidney cell clones) and primary lamb lingual epithelial cells upon BTV1 infection. Moreover, the results of a UV-inactivated BTV1 infection assay suggested that the induction of autophagy was dependent on BTV1 replication. Therefore, we investigated the role of autophagy in BTV1 replication. The inhibition of autophagy by pharmacological inhibitors (3-MA, CQ) and RNA interference (siBeclin1) significantly decreased viral protein synthesis and virus yields. In contrast, treating BSR cells with rapamycin, an inducer of autophagy, promoted viral protein expression and the production of infectious BTV1. These findings lead us to conclude that autophagy is activated by BTV1 and contributes to its replication, and provide novel insights into BTV-host interactions. PMID:26287233

  7. Autophagy Activated by Bluetongue Virus Infection Plays a Positive Role in Its Replication

    PubMed Central

    Lv, Shuang; Xu, Qingyuan; Sun, Encheng; Yang, Tao; Li, Junping; Feng, Yufei; Zhang, Qin; Wang, Haixiu; Zhang, Jikai; Wu, Donglai

    2015-01-01

    Bluetongue virus (BTV) is an important pathogen of wild and domestic ruminants. Despite extensive study in recent decades, the interplay between BTV and host cells is not clearly understood. Autophagy as a cellular adaptive response plays a part in many viral infections. In our study, we found that BTV1 infection triggers the complete autophagic process in host cells, as demonstrated by the appearance of obvious double-membrane autophagosome-like vesicles, GFP-LC3 dots accumulation, the conversion of LC3-I to LC3-II and increased levels of autophagic flux in BSR cells (baby hamster kidney cell clones) and primary lamb lingual epithelial cells upon BTV1 infection. Moreover, the results of a UV-inactivated BTV1 infection assay suggested that the induction of autophagy was dependent on BTV1 replication. Therefore, we investigated the role of autophagy in BTV1 replication. The inhibition of autophagy by pharmacological inhibitors (3-MA, CQ) and RNA interference (siBeclin1) significantly decreased viral protein synthesis and virus yields. In contrast, treating BSR cells with rapamycin, an inducer of autophagy, promoted viral protein expression and the production of infectious BTV1. These findings lead us to conclude that autophagy is activated by BTV1 and contributes to its replication, and provide novel insights into BTV-host interactions. PMID:26287233

  8. Brain activity in fairness consideration during asset distribution: does the initial ownership play a role?

    PubMed

    Wu, Yin; Hu, Jie; van Dijk, Eric; Leliveld, Marijke C; Zhou, Xiaolin

    2012-01-01

    Previous behavioral studies have shown that initial ownership influences individuals' fairness consideration and other-regarding behavior. However, it is not entirely clear whether initial ownership influences the brain activity when a recipient evaluates the fairness of asset distribution. In this study, we randomly assigned the bargaining property (monetary reward) to either the allocator or the recipient in the ultimatum game and let participants of the study, acting as recipients, receive either disadvantageous unequal, equal, or advantageous unequal offers from allocators while the event-related potentials (ERPs) were recorded. Behavioral results showed that participants were more likely to reject disadvantageous unequal and equal offers when they initially owned the property as compared to when they did not. The two types of unequal offers evoked more negative going ERPs (the MFN) than the equal offers in an early time window and the differences were not modulated by the initial ownership. In a late time window, however, the P300 responses to division schemes were affected not only by the type of unequal offers but also by whom the property was initially assigned to. These findings suggest that while the MFN may function as a general mechanism that evaluates whether the offer is consistent or inconsistent with the equity rule, the P300 is sensitive to top-down controlled processes, into which factors related to the allocation of attentional resources, including initial ownership and personal interests, come to play. PMID:22761850

  9. TGFβ signaling plays a critical role in promoting alternative macrophage activation

    PubMed Central

    2012-01-01

    Background Upon stimulation with different cytokines, macrophages can undergo classical or alternative activation to become M1 or M2 macrophages. Alternatively activated (or M2) macrophages are defined by their expression of specific gene products and play an important role in containing inflammation, removing apoptotic cells and repairing tissue damage. Whereas it is well-established that IL-4 can drive alternative activation, if lack of TGFβ signaling at physiological levels affects M2 polarization has not been addressed. Results Vav1-Cre x TβRIIfx/fx mice, lacking TβRII function in hematopoietic cells, exhibited uncontrolled pulmonary inflammation and developed a lethal autoimmune syndrome at young age. This was accompanied by significantly increased numbers of splenic neutrophils and T cells as well as elevated hepatic macrophage infiltration and bone marrow monocyte counts. TβRII-/- CD4+ and CD8+ T-cells in the lymph nodes and spleen expressed increased cell surface CD44, and CD69 was also higher on CD4+ lymph node T-cells. Loss of TβRII in bone marrow-derived macrophages (BMDMs) did not affect the ability of these cells to perform efferocytosis. However, these cells were defective in basal and IL-4-induced arg1 mRNA and Arginase-1 protein production. Moreover, the transcription of genes that are typically upregulated in M2-polarized macrophages, such as ym1, mcr2 and mgl2, was also decreased in peritoneal macrophages and IL-4-stimulated TβRII-/- BMDMs. We found that cell surface and mRNA expression of Galectin-3, which also regulates M2 macrophage polarization, was lower in TβRII-/- BMDMs. Very interestingly, the impaired ability of these null mutant BMDMs to differentiate into IL-4 polarized macrophages was Stat6- and Smad3-independent, but correlated with reduced levels of phospho-Akt and β-catenin. Conclusions Our results establish a novel biological role for TGFβ signaling in controlling expression of genes characteristic for alternatively

  10. Sweet Play

    ERIC Educational Resources Information Center

    Leung, Shuk-kwan S.; Lo, Jane-Jane

    2010-01-01

    This article features Sweet play math, a "math by the month" activity that involves decorating and making sugar cubes. Teachers may want to substitute straws, paper squares, alphabet blocks, or such commercially made manipulatives as Unifix[R] cubes for the real sweets. Given no allergy concerns, teachers and students alike would enjoy some sweet…

  11. Children's Active Learning through Unstructured Play in Malaysia

    ERIC Educational Resources Information Center

    Fatai O., Ismail Abdul; Faqih, Asrul; Bustan, Wafa K.

    2014-01-01

    Play is generally identified as a basic tool for effective learning and development in children. This study explores the ways in which amorphous or unstructured play contributes to children's overall development at the pre-primary level, helping to develop cognitive, social, and motor skills. The findings indicate that through unstructured…

  12. It's How You Play the Game: Cooperation Puts a Fun Spin on Children's Activities.

    ERIC Educational Resources Information Center

    Valentine, Glenda

    1995-01-01

    Cooperative games can teach children to work together. Fifteen games, suitable for three different age groups, are outlined. It is essential that everyone be allowed to play, but no one be forced to participate; criticisms, teasing, and rough play are not allowed, and rule changes must be accepted by everyone. (SLD)

  13. Contributing Factors on Malaysia Preschool Teachers' Belief, Attitude and Competence in Using Play Activities

    ERIC Educational Resources Information Center

    Jantan, Hafsah Binti; Bin Hamdan, Abdul Rahim; Yahya, Fauziah Hj; Saleh, Halimatussadiah Binti; Ong, Mohd Hanafi Bin Azman

    2015-01-01

    This study focused on preschool teachers' belief, attitude, knowledge and competence in using play in Malaysia. Its purpose is to find out indicators significantly contribute to belief, attitude, knowledge and competence in play of preschool teachers in Malaysia. The method used was factor analysis in order to confirm indicators in each variable…

  14. Analysis of surface EMG activation in hand percussion playing depending on the grasping type and the tempo

    PubMed Central

    Chong, Hyun Ju; Kim, Soo Ji; Lee, Eun Kyoung; Yoo, Ga Eul

    2015-01-01

    Although instrument playing-based training has been repeatedly reported to improve functional hand movements including grasping, the attempts to present quantitative information on physiological mechanism of grasping have been relatively insufficient to determine the type and the intensity of the exercises involved. This study aimed to examine the muscle activation during hand percussion playing depending on the grasping type and the playing tempo. A total of twelve healthy older adults with a mean age of 71.5 years participated in this study. Surface electrodes were placed on three grasping-related muscles: Flexor digitorum superficialis, extensor digitorum, and flexor pollicis brevis. Participants were instructed to play with the egg shaker, paddle drum mallet and clave involving different types of grasp at three different tempi (i.e., 80, 100, and 120 bpm) and sEMG data were collected during each playing. Significantly greater muscle activation was generated with the small sphere type of egg shaker, compared to the handle type of paddle drum mallet and the small cylinder type of clave. Playing at faster tempo also elicited significantly greater muscle activation than at slower tempo. With regard to the rise time of muscle activation, while tempo significantly affected the rise time, the time to peak muscle did not significantly change depending on the grasping type. This study confirmed that grasping pattern and the tempo of movement significantly influence the muscular activation of grasping involved in instrument playing. Based on these results, clinical implication for instrument selection and structured instrument playing would be suggested. PMID:26331139

  15. Analysis of surface EMG activation in hand percussion playing depending on the grasping type and the tempo.

    PubMed

    Chong, Hyun Ju; Kim, Soo Ji; Lee, Eun Kyoung; Yoo, Ga Eul

    2015-08-01

    Although instrument playing-based training has been repeatedly reported to improve functional hand movements including grasping, the attempts to present quantitative information on physiological mechanism of grasping have been relatively insufficient to determine the type and the intensity of the exercises involved. This study aimed to examine the muscle activation during hand percussion playing depending on the grasping type and the playing tempo. A total of twelve healthy older adults with a mean age of 71.5 years participated in this study. Surface electrodes were placed on three grasping-related muscles: Flexor digitorum superficialis, extensor digitorum, and flexor pollicis brevis. Participants were instructed to play with the egg shaker, paddle drum mallet and clave involving different types of grasp at three different tempi (i.e., 80, 100, and 120 bpm) and sEMG data were collected during each playing. Significantly greater muscle activation was generated with the small sphere type of egg shaker, compared to the handle type of paddle drum mallet and the small cylinder type of clave. Playing at faster tempo also elicited significantly greater muscle activation than at slower tempo. With regard to the rise time of muscle activation, while tempo significantly affected the rise time, the time to peak muscle did not significantly change depending on the grasping type. This study confirmed that grasping pattern and the tempo of movement significantly influence the muscular activation of grasping involved in instrument playing. Based on these results, clinical implication for instrument selection and structured instrument playing would be suggested. PMID:26331139

  16. Bringing the U.S. Senate to Your Classroom: A Role Play Activity.

    ERIC Educational Resources Information Center

    Hack, Ken

    1989-01-01

    Advocates role playing for teaching a unit on the legislative branch of government. Students were divided into political parties, sat on committees, and produced legislation. Concludes that experiencing the governmental process enhances citizen participation. (GG)

  17. The Structural Challenge: A Simple Design-Based Science Activity to Foster Creativity among Kinaesthetic Learners

    ERIC Educational Resources Information Center

    Amir, Nazir; Subramaniam, R.

    2014-01-01

    A suitable way for teachers to present science content and foster creativity in less academically inclined students is by getting them to engage in design-based science activities and guiding them along the way. This study illustrates how a design-and-make activity was carried out with the aim of getting students to showcase their creativity while…

  18. Using Analogy Role-Play Activity in an Undergraduate Biology Classroom to Show Central Dogma Revision

    ERIC Educational Resources Information Center

    Takemura, Masaharu; Kurabayashi, Mario

    2014-01-01

    For the study of biology in an undergraduate classroom, a classroom exercise was developed: an analogy role-play to learn mechanisms of gene transcription and protein translation (central dogma). To develop the central dogma role-play exercise, we made DNA and mRNA using paper sheets, tRNA using a wire dress hanger, and amino acids using Lego®…

  19. Seven Things Adult Learners Dislike.

    ERIC Educational Resources Information Center

    Strzalka, Agnieszka

    1998-01-01

    A questionnaire was designed to elicit what adult learners disliked most about learning English. Seven dislikes were identified, including the following: textbooks in English only, role plays, drills, textbooks with no reading material or with artificial texts, homework, inflexible teachers, and audiotapes. (Author/VWL)

  20. EFL Learners' Listening Comprehension and Awareness of Metacognitive Strategies: How Are They Related?

    ERIC Educational Resources Information Center

    Al-Alwan, Ahmed; Asassfeh, Sahail; Al-Shboul, Yousef

    2013-01-01

    Metacognitive strategies play an important role in many cognitive activities related to language use in oral communication. This study explored metacognitve listening strategies awareness and its relationship with listening comprehension on a convient sample of 386 tenth-grade EFL learners using two instruments: (a) Metacognition Awareness…

  1. Effects of High Level Prompts and Peer Assessment on Online Learners' Reflection Levels

    ERIC Educational Resources Information Center

    Chen, Nian-Shing; Wei, Chun-Wang; Wu, Kuen-Ting; Uden, Lorna

    2009-01-01

    Reflection plays a very important role in learning processes and is very helpful for promoting learning performance. Many higher education institutions today are actively promoting learners' reflection ability in order to help them cope with the fast changing world they will be entering when they graduate. Online learning provides potential for…

  2. Engaging Learners' Comprehension, Interest and Motivation to Learn Literature Using the Reader's Theatre

    ERIC Educational Resources Information Center

    Kabilan, Muhammad Kamarul; Kamarudin, Fadzliyati

    2010-01-01

    This article reports on a teacher's experiment with Reader's Theatre (RT), an interactive play reading activity with elements of reading aloud, drama and theatre, for her 20 unmotivated learners of literature in a premier school in Malaysia. Using RT, the students staged Angela Wright's "Potato People". The procedures and design of the study were…

  3. Comparison of electromyographic activity and range of neck motion in violin students with and without neck pain during playing.

    PubMed

    Park, Kyue-nam; Kwon, Oh-yun; Ha, Sung-min; Kim, Su-jung; Choi, Hyun-jung; Weon, Jong-hyuck

    2012-12-01

    Neck pain is common in violin students during a musical performance. The purpose of this study was to compare electromyographic (EMG) activity in superficial neck muscles with neck motion when playing the violin as well as neck range of motion (ROM) at rest, between violin students with and without neck pain. Nine violin students with neck pain and nine age- and gender-matched subjects without neck pain were recruited. Muscle activity of the bilateral upper trapezius, sternocleidomastoid, and superficial cervical extensor muscles was measured using surface EMG. Kinematic data on neck motion while playing and active neck ROM were also measured using a three-dimensional motion analysis system. Independent t-tests were used to compare EMG activity with kinematic data between groups. These analyses revealed that while playing, both the angle of left lateral bending and leftward rotation of the cervical spine were significantly greater in the neck pain group than among those without neck pain. Similarly, EMG activity of the left upper trapezius, both cervical extensors, and both sternocleidomastoid muscles were significantly greater in the neck pain group. The active ROM of left axial rotation was significantly lower in the neck pain group. These results suggest that an asymmetric playing posture and the associated increased muscle activity as well as decreased neck axial rotation may contribute to neck pain in violin students. PMID:23247874

  4. Match-play activity profile in elite women's rugby union players.

    PubMed

    Suarez-Arrones, Luis; Portillo, Javier; Pareja-Blanco, Fernando; Sáez de Villareal, Eduardo; Sánchez-Medina, Luis; Munguía-Izquierdo, Diego

    2014-02-01

    The aim of this study was to provide an objective description of the locomotive activities and exercise intensity undergone during the course of an international-level match of female rugby union. Eight players were analyzed using global positioning system tracking technology. The total distance covered by the players during the whole match was 5,820 ± 512 m. The backs covered significantly more distance than the forwards (6,356 ± 144 vs. 5,498 ± 412 m, respectively). Over this distance, 42.7% (2,487 ± 391 m) was spent standing or walking, 35% jogging (2,037 ± 315 m), 9.7% running at low intensity (566 ± 115 m), 9.5% at medium intensity (553 ± 190 m), 1.8% at high intensity (105 ± 74 m), and 1.2% sprinting (73 ± 107 m). There were significant differences in the distance covered by forwards and backs in certain speed zones. Analysis of the relative distance traveled over successive 10-minute period of match play revealed that the greatest distances were covered during the first (725 ± 53 m) and the last (702 ± 79 m) 10-minute period of the match. The average number of sprints, the average maximum distance of sprinting, the average minimum distance of sprinting, and the average sprint distance during the game were 4.7 ± 3.9 sprints, 20.6 ± 10.5 m, 5.8 ± 0.9 -m, and 12.0 ± 3.8 m, respectively. There were substantial differences between forwards and backs. Backs covered greater total distance, distance in certain speed zones, and sprinting performance. The players spent 46.9 ± 28.9% of match time between 91 and 100% of maximum heart rate and experienced a large number of impacts (accelerometer data and expressed as g forces) during the game. These findings offer important information to design better training strategies and physical fitness testing adapted to the specific demands of female rugby union. PMID:23698080

  5. Objects prompt authentic scientific activities among learners in a museum programme

    NASA Astrophysics Data System (ADS)

    Achiam, Marianne; Simony, Leonora; Kramer Lindow, Bent Erik

    2016-04-01

    Although the scientific disciplines conduct practical work in different ways, all consider practical work as the essential way of connecting objects and phenomena with ideas and the abstract. Accordingly, practical work is regarded as central to science education as well. We investigate a practical, object-based palaeontology programme at a natural history museum to identify how palaeontological objects prompt scientific activity among upper secondary school students. We first construct a theoretical framework based on an analysis of the programme's palaeontological content. From this, we build our reference model, which considers the specimens used in the programme, possible palaeontological interpretations of these specimens, and the conditions inherent in the programme. We use the reference model to analyse the activities of programme participants, and illustrate how these activities are palaeontologically authentic. Finally, we discuss our findings, examining the mechanism by which the specimens prompt scientific activities. We also discuss our discipline-based approach, and how it allows us to positively identify participants' activities as authentic. We conclude by discussing the implications of our findings.

  6. The Effect of Curricular Activities on Learner Autonomy: The Perspective of Undergraduate Mechanical Engineering Students

    ERIC Educational Resources Information Center

    Duarte, M.; Leite, C.; Mouraz, A.

    2016-01-01

    This study researches how first-year engineering students perceived the influence of curricular activities on their own learning autonomy, measured with an adaptation of the Personal Responsibility Orientation to Self-direction in Learning Scale (PRO-SDLS). Participants were questioned to assess the influence of the teacher's role. The results…

  7. The Effect of Post-Teaching Activity Type on Vocabulary Learning of Elementary EFL Learners

    ERIC Educational Resources Information Center

    Sadeghi, Karim; Sharifi, Faranak

    2013-01-01

    Considering the significant role of vocabulary in learning a language, and teachers' great responsibility in providing opportunities to facilitate this learning, many studies have focused on the best means of achieving a good knowledge of vocabulary. This study set out to investigate the effect of four post-teaching activities, namely game,…

  8. Growing into Greatness: A Study of a Local History Group of Active-Retired Learners

    ERIC Educational Resources Information Center

    Corrigan, Trudy; Byrne, Brid; Harris, Phyllis; Lalor, Maureen; O'Connor, Maura; O'Reilly, Kathleen; Quinn, Frank; Forde, Kathleen

    2005-01-01

    Research in Canada on the learning needs of older people looked at such issues as how to cope with changes in society, the need to make a contribution and the need to be influential. The White Paper on Adult Education "Learning for Life" notes that strategies for active ageing stress the critical importance of access to learning as a key tool in…

  9. Collaborative Syntactic Priming Activities and EFL Learners' Production of Wh-questions

    ERIC Educational Resources Information Center

    McDonough, Kim; Chaikitmongkol, Wanpen

    2010-01-01

    Syntactic priming is the tendency for a speaker to produce a structure that was encountered in recent discourse and is measured by calculating how frequently speakers use the modelled structures as opposed to alternatives. Recent lab-based studies have shown that carrying out syntactic priming activities with trained interlocutors positively…

  10. Research on the Healthy Lifestyle Model, Active Ageing, and Loneliness of Senior Learners

    ERIC Educational Resources Information Center

    Hung, Jui-Ying; Lu, Kuo-Song

    2014-01-01

    Taiwan has the fastest ageing population in the world. Thus, the government and local policy makers need to formulate policies not just for the nursing and care needs of the aged. They also need to actively promote the need for lifelong learning among seniors in order to achieve elderly-friendly objectives, such as health promotion and delays in…

  11. Towards Flexible Learning for Adult Learners in Professional Contexts: An Activity-Focused Course Design

    ERIC Educational Resources Information Center

    Cornelius, Sarah; Gordon, Carole; Ackland, Aileen

    2011-01-01

    This article argues for a flexible model of learning for adults which allows them to make choices and contextualise their learning in a manner appropriate to their own professional practice whilst also developing as a member of a learning community. It presents a design based around online "learning activities" which draws on ideas of…

  12. Investigating ESL Learners' Lexical Collocations: The Acquisition of Verb + Noun Collocations by Japanese Learners of English

    ERIC Educational Resources Information Center

    Miyakoshi, Tomoko

    2009-01-01

    Although it is widely acknowledged that collocations play an important part in second language learning, especially at intermediate-advanced levels, learners' difficulties with collocations have not been investigated in much detail so far. The present study examines ESL learners' use of verb-noun collocations, such as "take notes," "place an…

  13. A Framework for Gamified Activities Based on Mobile Games Played by Portuguese University Students

    ERIC Educational Resources Information Center

    Carvalho, Ana Amélia; Araújo, Inês; Zagalo, Nelson

    2014-01-01

    This paper starts by reporting the findings of a survey of Portuguese university students concerning their game habits and preferences. An online questionnaire was developed and 1101 answers were collected, 626 were mobile game players. The results from the survey indicate that the games most played by university students are essentially casual…

  14. Lessons from "A Really Useful Engine"[TM]: Using Thomas the Tank Engine[TM] to Examine the Relationship between Play as a Leading Activity, Imagination and Reality in Children's Contemporary Play Worlds

    ERIC Educational Resources Information Center

    Edwards, Susan

    2011-01-01

    This paper examines Vygotsky's conception of play as a leading activity in the contexts of children's contemporary play worlds. Commencing with an examination of the relationship between leading activities and the development of psychological functions, the paper moves into a consideration of the relationship between imagination and reality as a…

  15. Outdoor Play and Play Equipment.

    ERIC Educational Resources Information Center

    Naylor, Heather

    1985-01-01

    Discusses aspects of the play environment and its effect on children's play behavior. Indoor and outdoor play spaces are considered along with factors affecting the use of outdoor environments for play. Children's preferences for different outdoor play environments and for various play structures are explored. Guides for choosing play equipment…

  16. THE MORE CAPABLE LEARNER, GRADE 6.

    ERIC Educational Resources Information Center

    HANSEN, WILLIAM; AND OTHERS

    ENRICHMENT ACTIVITIES FOR TEACHER USE WITH CAPABLE LEARNERS ARE DISCUSSED. THE TEACHER'S SECTION CONTAINS--SUGGESTIONS FOR USING PUPIL MATERIALS, CHARACTERISTICS OF THE MORE ABLE STUDENT, A CHECKLIST FOR IDENTIFYING THE MORE ABLE STUDENTS, A CHART OF ACTIVITIES FOR THE CAPABLE LEARNER, AND A LIST OF MATERIALS AVAILABLE FROM THE CURRICULUM…

  17. Turning Reluctant Learners into Inspired Learners

    ERIC Educational Resources Information Center

    Sanacore, Joseph

    2008-01-01

    Motivation is a key factor in promoting academic success, and intrinsic motivation is especially important for developing autonomous learners. Reluctant learners, in particular, benefit from intrinsic motivation that makes learning relevant to their lives. In this article, the author describes commonalities of reluctant learners and presents…

  18. Beliefs and Out-of-Class Language Learning of Chinese-Speaking ESL Learners in Hong Kong

    ERIC Educational Resources Information Center

    Wu, Manfred Man-fat

    2012-01-01

    Background: There has been a lack of research on exploring how beliefs about language learning (BALLs) and out-of-class language-learning activities are related. BALLs and out-of-class language-learning activities play an important role in influencing the learning behaviours of learners and learning outcomes. Findings of this study provide useful…

  19. The Physiologic and Behavioral Implications of Playing Active and Sedentary Video Games in a Seated and Standing Position

    PubMed Central

    SANDERS, GABRIEL J.; REBOLD, MICHAEL; PEACOCK, COREY A.; WILLIAMSON, MEAGAN L.; SANTO, ANTONIO S.; BARKLEY, JACOB E.

    2014-01-01

    Previous studies have assessed physiologic response while playing video games per manufacturer instructions with participants standing during active video game play and seated during sedentary game play. It is not known whether an assigned seated or standing position affects positional preference and oxygen consumption (VO2) while gaming. The purpose of the study was to assess VO2 and preference of playing active and sedentary video games in a seated and standing position. VO2 was assessed in 25 participants during four, 20-minute conditions; resting, PlayStation 2 Madden NFL Football 2011, Nintendo Wii-Sports Boxing and Nintendo Wii Madden NFL Football 2011. Each condition was divided into two positional conditions (10 minutes seated, 10 minutes standing) and each participant indicated their positional preference after each 20-minute condition. Standing VO2 (4.4 ± 0.2 ml • kg−1 • min−1 PS2, 4.6 ± 0.1 ml • kg−1 • min−1 Wii Madden, 6.8 ± 0.3 ml • kg−1 • min−1Wii Boxing) was significantly (p ≤ 0.001) greater than seated VO2 (4.0 ± 0.1 ml • kg−1 • min−1 PS2, 4.2 ± 0.1 ml • kg−1 • min−1 Wii Madden, 6.1 ± 0.3 ml • kg−1 • min−1Wii Boxing) for each gaming condition. Participants preferred (p ≤ 0.001) to sit for all gaming conditions except Wii Boxing. Playing video games while standing increases VO2 to a greater extent than playing the same games in a seated position. Standing was only preferred for the most physiologically challenging game, Wii Boxing. Gaming position should be considered when assessing the physiologic and behavioral outcomes of playing video games.

  20. Educational Play: Mathematics. Games and Activities To Stimulate Your Child in Mathematics.

    ERIC Educational Resources Information Center

    Valentine, Deborah

    This book, written for parents, presents short mathematics activities for use with young children. Most chapters contain an overview, educational objectives, needed materials, an estimate of initial time investment, introduction and preparation instructions, and activities. Activities are grouped as follows: kitchen math, calculators, measurement,…

  1. "No Time to Play": Perceptions toward Physical Activity in Youth with Cystic Fibrosis

    ERIC Educational Resources Information Center

    Moola, Fiona; Faulkner, Guy E. J.; Schneiderman, Jane E.

    2012-01-01

    Although physical activity may reduce lung function decline in youth with cystic fibrosis (CF), most patients are inactive. Little is known about why youth with CF are inactive or how to facilitate physical activity. This study explored perceptions toward physical activity in 14 youth with CF at a Canadian Hospital. Qualitative interviews were…

  2. Providing Physical Activity for Students with Intellectual Disabilities: The Motivate, Adapt, and Play Program

    ERIC Educational Resources Information Center

    Davis, Kathy; Hodson, Patricia; Zhang, Guili; Boswell, Boni; Decker, Jim

    2010-01-01

    Research has shown that regular physical activity helps to prevent major health problems, such as heart disease, obesity, and diabetes. However, little research has been conducted on classroom-based physical activity programs for students with disabilities. In North Carolina, the Healthy Active Children Policy was implemented in 2006, requiring…

  3. Learner Personas in CALL

    ERIC Educational Resources Information Center

    Heift, Trude

    2007-01-01

    In examining the titles of this year's conference presentations, the author noticed quite a few papers that focus on learner-specific issues, for instance, papers that address learning styles, learner needs, personality and learning, learner modeling and, more generally, pedagogical issues that deal with individual learner differences in…

  4. Defining the Active Ingredients of Interactive Computer Play Interventions for Children with Neuromotor Impairments: A Scoping Review

    ERIC Educational Resources Information Center

    Levac, Danielle; Rivard, Lisa; Missiuna, Cheryl

    2012-01-01

    Rehabilitation researchers who investigate complex interventions are challenged to describe the "active ingredients" of their interventions: the reason(s) why a treatment is expected to be effective. Interactive Computer Play (ICP) is an emerging complex intervention in rehabilitation practice and research. The purpose of this scoping review is to…

  5. Teaching Children with Autism to Play a Video Game Using Activity Schedules and Game-Embedded Simultaneous Video Modeling

    ERIC Educational Resources Information Center

    Blum-Dimaya, Alyssa; Reeve, Sharon A.; Reeve, Kenneth F.; Hoch, Hannah

    2010-01-01

    Children with autism have severe and pervasive impairments in social interactions and communication that impact most areas of daily living and often limit independent engagement in leisure activities. We taught four children with autism to engage in an age-appropriate leisure skill, playing the video game Guitar Hero II[TM], through the use of (a)…

  6. Effectiveness of Group Activity Play Therapy on Internalizing and Externalizing Behavior Problems of Preadolescent Orphans in Uganda

    ERIC Educational Resources Information Center

    Ojiambo, Deborah

    2011-01-01

    This pilot study investigated the impact of group activity play therapy (GAPT) on displaced orphans aged 10 to 12 years living in a large children's village in Uganda. Teachers and housemothers identified 60 preadolescents exhibiting clinical levels of internalizing and externalizing behavior problems. The participants' ethnicity was…

  7. Neighbourhood for playing: using GPS, GIS, and accelerometry to delineate areas within which youth are physically active

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Abstract: Existing research suggests an association between the built environment characteristics of the neighborhood in which adolescents live and their level of physical activity. The geographic boundaries within which youth play are often arbitrarily assumed in existing research, but the geograph...

  8. The Relationship between Interaction with the Caregiver and the Emergence of Play Activities During the One-Word Period.

    ERIC Educational Resources Information Center

    Zukow, Patricia Goldring

    The relationship between interaction with the caregiver and the emergence of play activities during the one-word period was examined. In particular, investigation centered on Vygotsky's views regarding the importance of social interaction as the source of the child's knowledge of the world. To empirically examine the role of the caregiver,…

  9. Morphing into Adolescents: Active Word Learning for English-Language Learners and Their Classmates in Middle School

    ERIC Educational Resources Information Center

    Kieffer, Michael J.; Lesaux, Nonie K.

    2010-01-01

    Many students arrive at middle school without the academic language skills they need to read sophisticated texts with comprehension. In particular, English language learners and students from low-income backgrounds attending underresourced, urban middle schools lack opportunities to learn the thousands of academic words they need to succeed. To…

  10. Teacher-Made Tactile Science Materials with Critical and Creative Thinking Activities for Learners Including Those with Visual Impairments

    ERIC Educational Resources Information Center

    Teske, Jolene K.; Gray, Phyllis; Kuhn, Mason A.; Clausen, Courtney K.; Smith, Latisha L.; Alsubia, Sukainah A.; Ghayoorad, Maryam; Rule, Audrey C.; Schneider, Jean Suchsland

    2014-01-01

    Gifted students with visual impairments are twice exceptional learners and may not evidence their advanced science aptitudes without appropriate accommodations for learning science. However, effective tactile science teaching materials may be easily made. Recent research has shown that when tactile materials are used with "all" students…

  11. We Are What We Do: Examining Learner-Generated Content in the Anatomy Laboratory through the Lens of Activity Theory

    ERIC Educational Resources Information Center

    Doubleday, Alison F.; Wille, Sarah J.

    2014-01-01

    Video and photography are often used for delivering content within the anatomical sciences. However, instructors typically produce these resources to provide instructional or procedural information. Although the benefits of learner-generated content have been explored within educational research, virtually no studies have investigated the use of…

  12. Guiding Learners to near Native Fluency in English through an Adaptive Programme of Activities Which Includes Phoneme and Prosody Analysis

    ERIC Educational Resources Information Center

    Lawson, Alistair; Attridge, Ann; Lapok, Paul

    2014-01-01

    Many students of English language find pronunciation difficult to master. This work in progress paper discusses an incremental and iterative approach towards developing requirements for software applications to assist learners with the perception and production of English pronunciation in terms of phonemes and prosody. It was found that prompts…

  13. Style Shifts among Japanese Learners before and after Study Abroad in Japan: Becoming Active Social Agents in Japanese

    ERIC Educational Resources Information Center

    Iwasaki, Noriko

    2010-01-01

    Previous studies on L2 Japanese sojourners often reported that learners overuse the plain style or haphazardly mix the plain and polite styles upon return. These styles, which are often associated with formal or informal contexts, also index complex social and situational meanings, and native speakers are reported to shift their styles to create…

  14. Examining Student Cognitive and Affective Engagement and Reading Instructional Activities: Spanish-Speaking English Learners' Reading Profiles

    ERIC Educational Resources Information Center

    Barber, Ana Taboada; Gallagher, Melissa; Smith, Peet; Buehl, Michelle M.; Beck, Jori S.

    2016-01-01

    Recent research has emphasized the key role of engagement in helping students succeed in school and beyond. Given the academic struggles that many English learners (ELs) face as they transition to middle school, exploring the facets of engagement in middle school ELs is needed. We established reader profiles for eight sixth grade Hispanic ELs and…

  15. Ubiquitin plays an atypical role in GPCR-induced p38 MAP kinase activation on endosomes

    PubMed Central

    Grimsey, Neil J.; Aguilar, Berenice; Smith, Thomas H.; Le, Phillip; Soohoo, Amanda L.; Puthenveedu, Manojkumar A.; Nizet, Victor

    2015-01-01

    Protease-activated receptor 1 (PAR1) is a G protein–coupled receptor (GPCR) for thrombin and promotes inflammatory responses through multiple pathways including p38 mitogen-activated protein kinase signaling. The mechanisms that govern PAR1-induced p38 activation remain unclear. Here, we define an atypical ubiquitin-dependent pathway for p38 activation used by PAR1 that regulates endothelial barrier permeability. Activated PAR1 K63-linked ubiquitination is mediated by the NEDD4-2 E3 ubiquitin ligase and initiated recruitment of transforming growth factor-β–activated protein kinase-1 binding protein-2 (TAB2). The ubiquitin-binding domain of TAB2 was essential for recruitment to PAR1-containing endosomes. TAB2 associated with TAB1, which induced p38 activation independent of MKK3 and MKK6. The P2Y1 purinergic GPCR also stimulated p38 activation via NEDD4-2–mediated ubiquitination and TAB1–TAB2. TAB1–TAB2-dependent p38 activation was critical for PAR1-promoted endothelial barrier permeability in vitro, and p38 signaling was required for PAR1-induced vascular leakage in vivo. These studies define an atypical ubiquitin-mediated signaling pathway used by a subset of GPCRs that regulates endosomal p38 signaling and endothelial barrier disruption. PMID:26391660

  16. New Play.

    ERIC Educational Resources Information Center

    Lersten, Kenneth C.

    There have been many theories and hypotheses about play, one of which is the equation of play with "transcendence." Play may have the ingredients to allow us to transcend and, for a moment, remythologize life. There have been recent authors who have given play the status of theology, indicating that play contains elements also found in religion.…

  17. Playful Gaming.

    ERIC Educational Resources Information Center

    Makedon, Alexander

    A philosophical analysis of play and games is undertaken in this paper. Playful gaming, which is shown to be a synthesis of play and games, is utilized as a category for undertaking the examination of play and games. The significance of playful gaming to education is demonstrated through analyses of Plato's, Dewey's, Sartre's, and Marcuse's…

  18. Learn and Play in the Garden: Games, Crafts, and Activities for Children.

    ERIC Educational Resources Information Center

    Herd, Meg

    This book features activities, games, and crafts about gardening for children aged 6 to 12. The organization of the book is based on the seasons and the activities emphasize learning through fun. The spring section includes: (1) "Creating Your Own Vegetable Garden"; (2) "Safe Spraying"; (3) "What to Grow"; (4) "Cooking Your Vegetables"; (5) "Sally…

  19. Active Teaching of Diffusion through History of Science, Computer Animation and Role Playing

    ERIC Educational Resources Information Center

    Krajsek, Simona Strgulc; Vilhar, Barbara

    2010-01-01

    We developed and tested a lesson plan for active teaching of diffusion in secondary schools (grades 10-13), which stimulates understanding of the thermal (Brownian) motion of particles as the principle underlying diffusion. During the lesson, students actively explore the Brownian motion through microscope observations of irregularly moving small…

  20. Why Can't I Play Here? The Classroom: A World in Miniature. Instructional Activities Series.

    ERIC Educational Resources Information Center

    Witthuhn, Burton O.

    Third in the elementary set of teacher-developed instructional activities for teaching geography, this activity investigates spatial allocation through discussion and observation of classroom arrangements. Classroom space allocated for the teacher's desk, aisles, study area, and trash cans illustrates real-world locational concepts of geography…

  1. Active mechanistic target of rapamycin plays an ancillary rather than essential role in zebrafish CNS axon regeneration

    PubMed Central

    Diekmann, Heike; Kalbhen, Pascal; Fischer, Dietmar

    2015-01-01

    The developmental decrease of the intrinsic regenerative ability of the mammalian central nervous system (CNS) is associated with reduced activity of mechanistic target of rapamycin (mTOR) in mature neurons such as retinal ganglion cells (RGCs). While mTOR activity is further decreased upon axonal injury, maintenance of its pre-injury level, for instance by genetic deletion of the phosphatase and tensin homolog (PTEN), markedly promotes axon regeneration in mammals. The current study now addressed the question whether active mTOR might generally play a central role in axon regeneration by analyzing its requirement in regeneration-competent zebrafish. Remarkably, regulation of mTOR activity after optic nerve injury in zebrafish is fundamentally different compared to mammals. Hardly any activity was detected in naïve RGCs, whereas it was markedly increased upon axotomy in vivo as well as in dissociated cell cultures. After a short burst, mTOR activity was quickly attenuated, which is contrary to the requirements for axon regeneration in mammals. Surprisingly, mTOR activity was not essential for axonal growth per se, but correlated with cytokine- and PTEN inhibitor-induced neurite extension in vitro. Moreover, inhibition of mTOR using rapamycin significantly reduced axon regeneration in vivo and compromised functional recovery after optic nerve injury. Therefore, axotomy-induced mTOR activity is involved in CNS axon regeneration in zebrafish similar to mammals, although it plays an ancillary rather than essential role in this regeneration-competent species. PMID:26217179

  2. Playing to Learn: A Qualitative Analysis of Bilingual Pupil-Pupil Talk during Board Game Play

    ERIC Educational Resources Information Center

    Smith, Heather

    2006-01-01

    This paper explores what happens when bilingual learners come together to play a board game specially designed to facilitate an interactive context in which the learning of English as a second or additional language is promoted. An example of the interactive behaviour of one group of bilingual learners is then presented in order to illustrate such…

  3. Nuclear Factor of Activated T-cells (NFAT) plays a role in SV40 infection

    PubMed Central

    Manley, Kate; O’Hara, Bethany A; Atwood, Walter J

    2008-01-01

    Recent evidence highlighted a role for the transcription factor, Nuclear Factor of Activated T-cells (NFAT), in the transcription of the human polyomavirus JCV. Here we show that NFAT is also important in the transcriptional control of the related polyomavirus, Simian Virus 40 (SV40). Inhibition of NFAT activity reduced SV40 infection of Vero, 293A and HeLa cells, and this block occurred at the stage of viral transcription. Both NFAT3 and NFAT4 bound to the SV40 promoter through κB sites located within the 72bp repeated enhancer region. In Vero cells NFAT was involved in late transcription, but in HeLa and 293A cells both early and late viral transcription required NFAT activity. SV40 large T-Ag was found to increase NFAT activity and provided a positive feedback loop to transactivate the SV40 promoter. PMID:18031784

  4. Nuclear factor of activated T-cells (NFAT) plays a role in SV40 infection

    SciTech Connect

    Manley, Kate; O'Hara, Bethany A.; Atwood, Walter J.

    2008-03-01

    Recent evidence highlighted a role for the transcription factor, nuclear factor of activated T-cells (NFAT), in the transcription of the human polyomavirus JCV. Here we show that NFAT is also important in the transcriptional control of the related polyomavirus, Simian Virus 40 (SV40). Inhibition of NFAT activity reduced SV40 infection of Vero, 293A, and HeLa cells, and this block occurred at the stage of viral transcription. Both NFAT3 and NFAT4 bound to the SV40 promoter through {kappa}B sites located within the 72 bp repeated enhancer region. In Vero cells, NFAT was involved in late transcription, but in HeLa and 293A cells both early and late viral transcription required NFAT activity. SV40 large T-Ag was found to increase NFAT activity and provided a positive feedback loop to transactivate the SV40 promoter.

  5. Role-Playing Mitosis.

    ERIC Educational Resources Information Center

    Wyn, Mark A.; Stegink, Steven J.

    2000-01-01

    Introduces a role playing activity that actively engages students in the learning process of mitosis. Students play either chromosomes carrying information, or cells in the cell membrane. (Contains 11 references.) (Author/YDS)

  6. Wobble Pairs of the HDV Ribozyme Play Specific Roles in Stabilization of Active Site Dynamics

    PubMed Central

    Sripathi, Kamali N.; Banáš, Pavel; Reblova, Kamila; Šponer, Jiři; Otyepka, Michal

    2015-01-01

    The hepatitis delta virus (HDV) is the only known human pathogen whose genome contains a catalytic RNA motif (ribozyme). The overall architecture of the HDV ribozyme is that of a double-nested pseudoknot, with two GU pairs flanking the active site. Although extensive studies have shown that mutation of either wobble results in decreased catalytic activity, little work has focused on linking these mutations to specific structural effects on catalytic fitness. Here we use molecular dynamics simulations based on an activated structure to probe the active site dynamics as a result of wobble pair mutations. In both wild-type and mutant ribozymes, the in-line fitness of the active site (as a measure of catalytic proficiency) strongly depends on the presence of a C75(N3H3+)N1(O5′) hydrogen bond, which positions C75 as the general acid for the reaction. Our mutational analyses show that each GU wobble supports catalytically fit conformations in distinct ways; the reverse G25U20 wobble promotes high in-line fitness, high occupancy of the C75(N3H3+)G1(O5′) general-acid hydrogen bond and stabilization of the G1U37 wobble, while the G1U37 wobble acts more locally by stabilizing high in-line fitness and the C75(N3H3+)G1(O5′) hydrogen bond. We also find that stable type I A-minor and P1.1 hydrogen bonding above and below the active site, respectively, prevent local structural disorder from spreading and disrupting global conformation. Taken together, our results define specific, often redundant architectural roles for several structural motifs of the HDV ribozyme active site, expanding the known roles of these motifs within all HDV-like ribozymes and other structured RNAs. PMID:25631765

  7. Engaging Learner Support: An Investigation of Faculty-Library Collaboration to Provide Live Course-Specific Learner Support in the Online Classroom Environment

    ERIC Educational Resources Information Center

    Fields, Alison

    2014-01-01

    Collaboration between faculty and learner support can create seamless services for e-learners. Providing access to learning materials and activities with co-located tailored learner support creates an environment in which e-learners can easily access everything they need for an enhanced, supported, and more focused learning experience. The…

  8. Oxidative stress plays a role in high glucose-induced activation of pancreatic stellate cells

    SciTech Connect

    Ryu, Gyeong Ryul; Lee, Esder; Chun, Hyun-Ji; Yoon, Kun-Ho; Ko, Seung-Hyun; Ahn, Yu-Bae; Song, Ki-Ho

    2013-09-20

    Highlights: •High glucose increased production of reactive oxygen species in cultured pancreatic stellate cells. •High glucose facilitated the activation of these cells. •Antioxidant treatment attenuated high glucose-induced activation of these cells. -- Abstract: The activation of pancreatic stellate cells (PSCs) is thought to be a potential mechanism underlying islet fibrosis, which may contribute to progressive β-cell failure in type 2 diabetes. Recently, we demonstrated that antioxidants reduced islet fibrosis in an animal model of type 2 diabetes. However, there is no in vitro study demonstrating that high glucose itself can induce oxidative stress in PSCs. Thus, PSCs were isolated and cultured from Sprague Dawley rats, and treated with high glucose for 72 h. High glucose increased the production of reactive oxygen species. When treated with high glucose, freshly isolated PSCs exhibited myofibroblastic transformation. During early culture (passage 1), PSCs treated with high glucose contained an increased number of α-smooth muscle actin-positive cells. During late culture (passages 2–5), PSCs treated with high glucose exhibited increases in cell proliferation, the expression of fibronectin and connective tissue growth factor, release of interleukin-6, transforming growth factor-β and collagen, and cell migration. Finally, the treatment of PSCs with high glucose and antioxidants attenuated these changes. In conclusion, we demonstrated that high glucose increased oxidative stress in primary rat PSCs, thereby facilitating the activation of these cells, while antioxidant treatment attenuated high glucose-induced PSC activation.

  9. Cdk1 plays matchmaker for the Polo-like kinase and its activator SPAT-1/Bora.

    PubMed

    Tavernier, Nicolas; Panbianco, Costanza; Gotta, Monica; Pintard, Lionel

    2015-08-01

    Mitosis is orchestrated by several protein kinases including Cdks, Plks and Aurora kinases. Despite considerable progress toward understanding the individual function of these protein kinases, how their activity is coordinated in space and time during mitosis is less well understood. In a recent article published in the Journal of Cell Biology, we show that CDK-1 regulates PLK-1 activity during mitosis in C. elegans embryos through multisite phosphorylation of the PLK-1 activator SPAT-1 (Aurora Borealis, Bora in human). SPAT-1 variants mutated on CDK-1 phosphorylation sites results in severe delays in mitotic entry, mimicking embryos lacking spat-1 or plk-1 function. We further show that SPAT-1 phosphorylation by CDK-1 promotes its binding to PLK-1 and stimulates PLK-1 phosphorylation on its activator T-loop by Aurora A kinase in vitro. Likewise, we find that phosphorylation of Bora by Cdk1 promotes phosphorylation of human Plk1 by Aurora A suggesting that this mechanism is conserved in humans. These results indicate that Cdk1 regulates Plk1 by boosting its kinase activity. Here we discuss these recent findings and open questions regarding the regulation of Plk1/PLK-1 by Cdk1/CDK-1 and Bora/SPAT-1. PMID:26038951

  10. Semiotic Activity of Young Children in Play: The Construction and Use of Schematic Representations.

    ERIC Educational Resources Information Center

    van Oers, Bert

    1994-01-01

    Examined four- through six-year olds' ability to diagram the configuration of a toy railway set they had assembled and to reconstruct the railway based on drawings. Found that motivation had a significant influence on the accuracy of drawings. Results suggest that semiotic activity with the help of schematic representations or drawings is in the…

  11. Problem Articulation and the Processes of Assistance: An Activity Theoretic View of Mediation in Game Play

    ERIC Educational Resources Information Center

    Stone, Lynda D.; Gutierrez, Kris D.

    2007-01-01

    In this article, we study a local adaptation of the Fifth Dimension [Cole, M. (1996). "Cultural psychology: A once and future discipline." Cambridge: Cambridge University Press] known as Las Redes (i.e., Networks of Collaboration in the Fifth Dimension) to examine how the multiple activity systems of Las Redes, e.g. the undergraduate course and…

  12. E1 Ubiquitin-Activating Enzyme UBA-1 Plays Multiple Roles throughout C. elegans Development

    PubMed Central

    Kulkarni, Madhura; Smith, Harold E.

    2008-01-01

    Poly-ubiquitination of target proteins typically marks them for destruction via the proteasome and provides an essential mechanism for the dynamic control of protein levels. The E1 ubiquitin-activating enzyme lies at the apex of the ubiquitination cascade, and its activity is necessary for all subsequent steps in the reaction. We have isolated a temperature-sensitive mutation in the Caenorhabditis elegans uba-1 gene, which encodes the sole E1 enzyme in this organism. Manipulation of UBA-1 activity at different developmental stages reveals a variety of functions for ubiquitination, including novel roles in sperm fertility, control of body size, and sex-specific development. Levels of ubiquitin conjugates are substantially reduced in the mutant, consistent with reduced E1 activity. The uba-1 mutation causes delays in meiotic progression in the early embryo, a process that is known to be regulated by ubiquitin-mediated proteolysis. The uba-1 mutation also demonstrates synthetic lethal interactions with alleles of the anaphase-promoting complex, an E3 ubiquitin ligase. The uba-1 mutation provides a sensitized genetic background for identifying new in vivo functions for downstream components of the ubiquitin enzyme cascade, and it is one of the first conditional mutations reported for the essential E1 enzyme in a metazoan animal model. PMID:18636104

  13. Parental Support Exceeds Parenting Style for Promoting Active Play in Preschool Children

    ERIC Educational Resources Information Center

    Schary, David P.; Cardinal, Bradley J.; Loprinzi, Paul D.

    2012-01-01

    Emerging evidence suggests that parenting style may directly or indirectly influence school-aged children's activity behaviour. Given that relatively fewer studies have been conducted among preschool-aged children, this study's primary purpose was to examine the direct relationships between parental support and parenting style on preschool…

  14. Leveling the Playing Field: First Generation Korean American Males and School Based Extracurricular Activities

    ERIC Educational Resources Information Center

    Levy, Corey

    2010-01-01

    This study examined the manner in which extracurricular activities impacted the acculturation of first-generation adolescent males. Specifically, the project focused on the influence of organized high school soccer on the development of first-generation adolescent Korean American males. Eight adolescent participants, ranging in age from fourteen…

  15. The Development of Expert Learners in the Classroom

    ERIC Educational Resources Information Center

    Rahman, Saemah; Mahmud, Zuria; Yassin, Siti Fatimah Mohd; Amir, Ruslin; Ilias, Khadijah Wan

    2010-01-01

    The term "expert learner" refers to students who are actively engaged with the materials learned and take responsibility for their own learning. Literature reviews suggested the use of metacognitive approach to help develop students to become expert learners. Research on development of expert learners can be traced from movements that…

  16. Using Blended Learning to Increase Learner Support and Improve Retention

    ERIC Educational Resources Information Center

    Hughes, Gwyneth

    2007-01-01

    Improving retention and identifying "at risk" learners are high profile issues in higher education, and a proposed solution is to provide good learner support. Blending of online learning with classroom sessions offers the potential to use a virtual learning environment to deliver learning activities, and to support learners using a distance…

  17. The Tip of the Iceberg: Factors Affecting Learner Motivation

    ERIC Educational Resources Information Center

    Littlejohn, Andrew

    2008-01-01

    Teachers' informal discussions of learner motivation often emphasize the need to find ways to motivate learners, most usually through "fun" or "dynamic" activities. This paper starts from the assumption, however, that part of the work of the teacher is to avoid the "demotivation" of learners, and that there is a need to consider the overall…

  18. Active chromatin and transcription play a key role in chromosome partitioning into topologically associating domains

    PubMed Central

    Ulianov, Sergey V.; Khrameeva, Ekaterina E.; Gavrilov, Alexey A.; Flyamer, Ilya M.; Kos, Pavel; Mikhaleva, Elena A.; Penin, Aleksey A.; Logacheva, Maria D.; Imakaev, Maxim V.; Chertovich, Alexander; Gelfand, Mikhail S.; Shevelyov, Yuri Y.; Razin, Sergey V.

    2016-01-01

    Recent advances enabled by the Hi-C technique have unraveled many principles of chromosomal folding that were subsequently linked to disease and gene regulation. In particular, Hi-C revealed that chromosomes of animals are organized into topologically associating domains (TADs), evolutionary conserved compact chromatin domains that influence gene expression. Mechanisms that underlie partitioning of the genome into TADs remain poorly understood. To explore principles of TAD folding in Drosophila melanogaster, we performed Hi-C and poly(A)+ RNA-seq in four cell lines of various origins (S2, Kc167, DmBG3-c2, and OSC). Contrary to previous studies, we find that regions between TADs (i.e., the inter-TADs and TAD boundaries) in Drosophila are only weakly enriched with the insulator protein dCTCF, while another insulator protein Su(Hw) is preferentially present within TADs. However, Drosophila inter-TADs harbor active chromatin and constitutively transcribed (housekeeping) genes. Accordingly, we find that binding of insulator proteins dCTCF and Su(Hw) predicts TAD boundaries much worse than active chromatin marks do. Interestingly, inter-TADs correspond to decompacted inter-bands of polytene chromosomes, whereas TADs mostly correspond to densely packed bands. Collectively, our results suggest that TADs are condensed chromatin domains depleted in active chromatin marks, separated by regions of active chromatin. We propose the mechanism of TAD self-assembly based on the ability of nucleosomes from inactive chromatin to aggregate, and lack of this ability in acetylated nucleosomal arrays. Finally, we test this hypothesis by polymer simulations and find that TAD partitioning may be explained by different modes of inter-nucleosomal interactions for active and inactive chromatin. PMID:26518482

  19. The linker connecting the two kringles plays a key role in prothrombin activation

    PubMed Central

    Pozzi, Nicola; Chen, Zhiwei; Pelc, Leslie A.; Shropshire, Daniel B.; Di Cera, Enrico

    2014-01-01

    The zymogen prothrombin is proteolytically converted by factor Xa to the active protease thrombin in a reaction that is accelerated >3,000-fold by cofactor Va. This physiologically important effect is paradigmatic of analogous cofactor-dependent reactions in the coagulation and complement cascades, but its structural determinants remain poorly understood. Prothrombin has three linkers connecting the N-terminal Gla domain to kringle-1 (Lnk1), the two kringles (Lnk2), and kringle-2 to the C-terminal protease domain (Lnk3). Recent developments indicate that the linkers, and particularly Lnk2, confer on the zymogen significant flexibility in solution and enable prothrombin to sample alternative conformations. The role of this flexibility in the context of prothrombin activation was tested with several deletions. Removal of Lnk2 in almost its entirety (ProTΔ146–167) drastically reduces the enhancement of thrombin generation by cofactor Va from >3,000-fold to 60-fold because of a significant increase in the rate of activation in the absence of cofactor. Deletion of Lnk2 mimics the action of cofactor Va and offers insights into how prothrombin is activated at the molecular level. The crystal structure of ProTΔ146–167 reveals a contorted architecture where the domains are not vertically stacked, kringle-1 comes within 9 Å of the protease domain, and the Gla-domain primed for membrane binding comes in contact with kringle-2. These findings broaden our molecular understanding of a key reaction of the blood coagulation cascade where cofactor Va enhances activation of prothrombin by factor Xa by compressing Lnk2 and morphing prothrombin into a conformation similar to the structure of ProTΔ146–167. PMID:24821807

  20. Affecting Girls' Activity and Job Interests Through Play: The Moderating Roles of Personal Gender Salience and Game Characteristics.

    PubMed

    Coyle, Emily F; Liben, Lynn S

    2016-03-01

    Gender schema theory (GST) posits that children approach opportunities perceived as gender appropriate, avoiding those deemed gender inappropriate, in turn affecting gender-differentiated career trajectories. To test the hypothesis that children's gender salience filters (GSF-tendency to attend to gender) moderate these processes, 62 preschool girls (M = 4.5 years) were given GSF measures. Two weeks later, they played a computer game about occupations that manipulated the game-character's femininity (hyperfeminized Barbie vs. less feminized Playmobil Jane). Following game play, girls' interests in feminine activities showed an interaction of game condition and GSF: High-GSF girls showed intensified feminine activity interests only with Barbie; low-GSF girls showed no change with either character. Neither GSF nor game condition affected occupational interests. Implications for GST, individual differences, and occupational interventions are discussed. PMID:26548652

  1. Rap1 Activation Plays a Regulatory Role in Pancreatic Amylase Secretion*S⃞

    PubMed Central

    Sabbatini, Maria E.; Chen, Xuequn; Ernst, Stephen A.; Williams, John A.

    2008-01-01

    Rap1 is a member of the Ras superfamily of small GTP-binding proteins and is localized on pancreatic zymogen granules. The current study was designed to determine whether GTP-Rap1 is involved in the regulation of amylase secretion. Rap1A/B and the two Rap1 guanine nucleotide exchange factors, Epac1 and CalDAG-GEF III, were identified in mouse pancreatic acini. A fraction of both Rap1 and Epac1 colocalized with amylase in zymogen granules, but only Rap1 was integral to the zymogen granule membranes. Stimulation with cholecystokinin (CCK), carbachol, and vasoactive intestinal peptide all induced Rap1 activation, as did calcium ionophore A23187, phorbol ester, forskolin, 8-bromo-cyclic AMP, and the Epac-specific cAMP analog 8-pCPT-2′-O-Me-cAMP. The phospholipase C inhibitor U-73122 abolished carbachol- but not forskolin-induced Rap1 activation. Co-stimulation with carbachol and 8-pCPT-2′-O-Me-cAMP led to an additive effect on Rap1 activation, whereas a synergistic effect was seen on amylase release. Although the protein kinase A inhibitor H-89 abolished forskolin-stimulated CREB phosphorylation, it did not modify forskolin-induced GTP-Rap1 levels, excluding PKA participation. Overexpression of Rap1 GTPase-activating protein, which blocked Rap1 activation, reduced the effect of 8-bromo-cyclic AMP, 8-pCPT-2′-O-Me-cAMP, and vasoactive intestinal peptide on amylase release by 60% and reduced CCK- as well as carbachol-stimulated pancreatic amylase release by 40%. These findings indicate that GTP-Rap1 is required for pancreatic amylase release. Rap1 activation not only mediates the cAMP-evoked response via Epac1 but is also involved in CCK- and carbachol-induced amylase release, with their action most likely mediated by CalDAG-GEF III. PMID:18577515

  2. FoxO1-Mediated Activation of Akt Plays a Critical Role in Vascular Homeostasis

    PubMed Central

    Yuan, Lei; Dupuis, Dylan; Beeler, David; Spokes, Katherine C.; Janes, Lauren; Sciuto, Tracey; Kang, Peter M.; Jaminet, Shou-Ching S.; Dvorak, Ann; Grant, Marianne A.; Regan, Erzsébet Ravasz; Aird, William C.

    2016-01-01

    Rationale Forkhead box-O transcription factors (FoxOs) transduce a wide range of extracellular signals, resulting in changes in cell survival, cell cycle progression, and a number of cell type-specific responses. FoxO1 is expressed in many cell types, including endothelial cells. Previous studies have shown that FoxO1 knockout in mice results in embryonic lethality at E11 due to impaired vascular development. In contrast, somatic deletion of FoxO1 is associated with hyperproliferation of endothelial cells. Thus, the precise role of FoxO1 in the endothelium remains enigmatic. Objective To determine the effect of endothelial-specific knockout and overexpression of FoxO1 on vascular homeostasis. Methods and Results We show that endothelial cell (EC)-specific disruption of FoxO1 in mice phenocopies the full knockout. While endothelial expression of FoxO1 rescued otherwise FoxO-null animals, overexpression of constitutively active FoxO1 resulted in increased EC size, occlusion of capillaries, elevated peripheral resistance, heart failure and death. Knockdown of FoxO1 in ECs resulted in marked inhibition of basal and VEGF-induced Akt-mTOR1 signaling. Conclusions Our findings suggest that in mice endothelial expression of FoxO1 is both necessary and sufficient for embryonic development. Moreover, FoxO1-mediated feedback activation of Akt maintains growth factor-responsive Akt/mTORC1 activity within a homeostatic range. PMID:24874427

  3. Cell fusion in osteoclasts plays a critical role in controlling bone mass and osteoblastic activity

    SciTech Connect

    Iwasaki, Ryotaro; Ninomiya, Ken; Miyamoto, Kana; Suzuki, Toru; Sato, Yuiko

    2008-12-19

    The balance between osteoclast and osteoblast activity is central for maintaining the integrity of bone homeostasis. Here we show that mice lacking dendritic cell specific transmembrane protein (DC-STAMP), an essential molecule for osteoclast cell-cell fusion, exhibited impaired bone resorption and upregulation of bone formation by osteoblasts, which do not express DC-STAMP, which led to increased bone mass. On the contrary, DC-STAMP over-expressing transgenic (DC-STAMP-Tg) mice under the control of an actin promoter showed significantly accelerated cell-cell fusion of osteoclasts and bone resorption, with decreased osteoblastic activity and bone mass. Bone resorption and formation are known to be regulated in a coupled manner, whereas DC-STAMP regulates bone homeostasis in an un-coupled manner. Thus our results indicate that inhibition of a single molecule provides both decreased osteoclast activity and increased bone formation by osteoblasts, thereby increasing bone mass in an un-coupled and a tissue specific manner.

  4. Silent play in a loud theatre - soil development in a geomorphically active proglacial area

    NASA Astrophysics Data System (ADS)

    Harlaar, Piet; Temme, Arnaud; Heckmann, Tobias

    2015-04-01

    Proglacial areas are scientifically famous for two sets of processes: first, the tumultuous geomorphic response to glacial retreat including enhanced fluvial activity and mass movements such as debris flows, rock fall and landslides. Second, the slow and somewhat regular development of soil and vegetation. These two sets of processes have usually been studied in isolation: soil development is best observed in wide, flat proglacial areas where not much geomorphic work is done. This has left questions unanswered that relate to the effect of geomorphic disturbance on high mountain soil formation, and vice versa. We attempted to characterize these interactions in the geomorphically active proglacial area of the Gepatsch Ferner in the Kaunertal in Austria. Geomorphic activity in this area is intensively studied in the PROSA project. In our study, several dozen soils were sampled in order to describe soil properties. Sampling locations were selected with Latin Hypercube sampling to best cover the variation in soil-forming factors. Results clearly showed that soil properties were not only a function of age, but also of erosion-deposition amounts and geomorphic regime. In contrast to what is reported in literature, soil pH in very young soils rose before it dropped as soils became older. The early pH rise probably reflects the leaching of pyrite in the parent material.

  5. Mitofusin 1 and 2 play distinct roles in mitochondrial fusion reactions via GTPase activity.

    PubMed

    Ishihara, Naotada; Eura, Yuka; Mihara, Katsuyoshi

    2004-12-15

    The mammalian homologues of yeast and Drosophila Fzo, mitofusin (Mfn) 1 and 2, are both essential for mitochondrial fusion and maintenance of mitochondrial morphology. Though the GTPase domain is required for Mfn protein function, the molecular mechanisms of the GTPase-dependent reaction as well as the functional division of the two Mfn proteins are unknown. To examine the function of Mfn proteins, tethering of mitochondrial membranes was measured in vitro by fluorescence microscopy using green fluorescence protein- or red fluorescent protein-tagged and Mfn1-expressing mitochondria, or by immunoprecipitation using mitochondria harboring HA- or FLAG-tagged Mfn proteins. These experiments revealed that Mfn1-harboring mitochondria were efficiently tethered in a GTP-dependent manner, whereas Mfn2-harboring mitochondria were tethered with only low efficiency. Sucrose density gradient centrifugation followed by co-immunoprecipitation revealed that Mfn1 produced oligomerized approximately 250 kDa and approximately 450 kDa complexes in a GTP-dependent manner. The approximately 450 kDa complex contained oligomerized Mfn1 from distinct apposing membranes (docking complex), whereas the approximately 250 kDa complex was composed of Mfn1 present on the same membrane or in the membrane-solubilized state (cis complex). These results were also confirmed using blue-native PAGE. Mfn1 exhibited higher activity for this reaction than Mfn2. Purified recombinant Mfn1 exhibited approximately eightfold higher GTPase activity than Mfn2. These findings indicate that the two Mfn proteins have distinct activities, and suggest that Mfn1 is mainly responsible for GTP-dependent membrane tethering. PMID:15572413

  6. Autocrine abscisic acid plays a key role in quartz-induced macrophage activation.

    PubMed

    Magnone, Mirko; Sturla, Laura; Jacchetti, Emanuela; Scarfì, Sonia; Bruzzone, Santina; Usai, Cesare; Guida, Lucrezia; Salis, Annalisa; Damonte, Gianluca; De Flora, Antonio; Zocchi, Elena

    2012-03-01

    Inhalation of quartz induces silicosis, a lung disease where alveolar macrophages release inflammatory mediators, including prostaglandin-E(2) (PGE(2)) and tumor necrosis factor α (TNF-α). Here we report the pivotal role of abscisic acid (ABA), a recently discovered human inflammatory hormone, in silica-induced activation of murine RAW264.7 macrophages and of rat alveolar macrophages (AMs). Stimulation of both RAW264.7 cells and AMs with quartz induced a significant increase of ABA release (5- and 10-fold, respectively), compared to untreated cells. In RAW264.7 cells, autocrine ABA released after quartz stimulation sequentially activates the plasma membrane receptor LANCL2 and NADPH oxidase, generating a Ca(2+) influx resulting in NFκ B nuclear translocation and PGE(2) and TNF-α release (3-, 2-, and 3.5-fold increase, respectively, compared to control, unstimulated cells). Quartz-stimulated RAW264.7 cells silenced for LANCL2 or preincubated with a monoclonal antibody against ABA show an almost complete inhibition of NFκ B nuclear translocation and PGE(2) and TNF-α release compared to controls electroporated with a scramble oligonucleotide or preincubated with an unrelated antibody. AMs showed similar early and late ABA-induced responses as RAW264.7 cells. These findings identify ABA and LANCL2 as key mediators in quartz-induced inflammation, providing possible new targets for antisilicotic therapy. PMID:22042223

  7. Plasmodium falciparum Adhesins Play an Essential Role in Signalling and Activation of Invasion into Human Erythrocytes

    PubMed Central

    Tham, Wai-Hong; Lim, Nicholas T. Y.; Weiss, Greta E.; Lopaticki, Sash; Ansell, Brendan R. E.; Bird, Megan; Lucet, Isabelle; Dorin-Semblat, Dominique; Doerig, Christian; Gilson, Paul R.; Crabb, Brendan S.; Cowman, Alan F.

    2015-01-01

    The most severe form of malaria in humans is caused by the protozoan parasite Plasmodium falciparum. The invasive form of malaria parasites is termed a merozoite and it employs an array of parasite proteins that bind to the host cell to mediate invasion. In Plasmodium falciparum, the erythrocyte binding-like (EBL) and reticulocyte binding-like (Rh) protein families are responsible for binding to specific erythrocyte receptors for invasion and mediating signalling events that initiate active entry of the malaria parasite. Here we have addressed the role of the cytoplasmic tails of these proteins in activating merozoite invasion after receptor engagement. We show that the cytoplasmic domains of these type 1 membrane proteins are phosphorylated in vitro. Depletion of PfCK2, a kinase implicated to phosphorylate these cytoplasmic tails, blocks P. falciparum invasion of red blood cells. We identify the crucial residues within the PfRh4 cytoplasmic domain that are required for successful parasite invasion. Live cell imaging of merozoites from these transgenic mutants show they attach but do not penetrate erythrocytes implying the PfRh4 cytoplasmic tail conveys signals important for the successful completion of the invasion process. PMID:26694741

  8. TAF7 (TAFII55) plays a role in the transcription activation by c-Jun.

    PubMed

    Munz, Christine; Psichari, Eleni; Mandilis, Dimitris; Lavigne, Anne-Claire; Spiliotaki, Maria; Oehler, Thomas; Davidson, Irwin; Tora, Laszlo; Angel, Peter; Pintzas, Alexander

    2003-06-13

    c-Jun is a member of the AP-1 family of transcription factors regulating expression of specific target genes in a variety of cellular processes including proliferation, stress response, and tumorigenicity. In the present study we have analyzed the mechanism of c-Jun function as a transactivator with respect to members of the basal transcription machinery, TATA-binding protein-associated factors (TAFs). We show that one member of the family, human TAF7 (formerly TAFII55), physically interacts with c-Jun through two independent interaction domains, within the N- and C-terminal part of c-Jun. Interaction in vitro correlates with enhanced transactivation function of c-Jun in HEK293 and COS cells in the presence of increasing amounts of TAF7. TAF7 interacts preferentially with DNA-bound phosphorylated c-Jun, suggesting that TAF7 represents a novel c-Jun co-activator mediating activation of AP-1 target genes in response to extracellular signals. PMID:12676957

  9. Integrating Learner Corpora and Natural Language Processing: A Crucial Step towards Reconciling Technological Sophistication and Pedagogical Effectiveness

    ERIC Educational Resources Information Center

    Granger, Sylviane; Kraif, Olivier; Ponton, Claude; Antoniadis, Georges; Zampa, Virginie

    2007-01-01

    Learner corpora, electronic collections of spoken or written data from foreign language learners, offer unparalleled access to many hitherto uncovered aspects of learner language, particularly in their error-tagged format. This article aims to demonstrate the role that the learner corpus can play in CALL, particularly when used in conjunction with…

  10. Developing Positive School-Home Relationships through Structured Conversations with Parents of Learners with Special Educational Needs and Disabilities (SEND)

    ERIC Educational Resources Information Center

    Lendrum, Ann; Barlow, Alexandra; Humphrey, Neil

    2015-01-01

    Parents play a crucial role in their children's education, and their active involvement can lead to better outcomes. However, evidence suggests that parental engagement and confidence among perhaps the most vulnerable group of learners--those with special educational needs and disabilities (SEND)--may be lower than for those without difficulties.…

  11. "The boys won't let us play:" fifth-grade mestizas challenge physical activity discourse at school.

    PubMed

    Oliver, Kimberly L; Hamzeh, Manal

    2010-03-01

    Drawing on feminist, critical, and poststructural theories, the purpose of this research was: (a) to understand fifth-grade mestizas self-identified barriers to physical activity, and (b) to work with them to develop strategies for challenging these barriers. Data were collected over the 2005-06 school year. Our interpretations are divided into three sections: (a) the barriers the girls identified to their physical activity participation; (b) how we worked with them to study their primary self-identified barrier to physical activity--"the boy's won't let us play"; and (c) how we refocused our research to help the girls publicize their barrier to challenge the inequities in physical activity at their school. PMID:20387397

  12. Does antidromic activation of nociceptors play a role in sciatic radicular pain?

    PubMed

    Xavier, A V; Farrell, C E; McDanal, J; Kissin, I

    1990-01-01

    We describe a case where transcutaneous electrical stimulation of the right sciatic nerve in a patient with right L5 radiculopathy reproduced the patient's pathological pain in the leg. Following a right ankle block with 0.5% bupivacaine, the sciatic nerve stimulation induced pain in the thigh and the calf but not in the foot. Despite an increase in the magnitude of stimulation by 50% (compared with the stimulation before the block) the pain was not perceived below the level of blockade. We suggest that in this case the electrical stimulation generated impulses propagated antidromically into the leg and activated nociceptors in it. The bupivacaine blockade prevented antidromic propagation of impulses into the foot, therefore pain in this region was not perceived. PMID:2339019

  13. Expanded Perspectives on Autonomous Learners

    ERIC Educational Resources Information Center

    Oxford, Rebecca L.

    2015-01-01

    This paper explores two general perspectives on autonomous learners: psychological and sociocultural. These perspectives introduce a range of theoretically grounded facets of autonomous learners, facets such as the self-regulated learner, the emotionally intelligent learner, the self-determined learner, the mediated learner, the socioculturally…

  14. Hypothesis That Urethral Bulb (Corpus Spongiosum) Plays an Active Role in Male Urinary Continence

    PubMed Central

    Rehder, Peter; Staudacher, Nina M.; Schachtner, Joerg; Berger, Maria E.; Schillfahrt, Florian; Hauser, Verena; Mueller, Raphael; Skradski, Viktor; Horninger, Wolfgang; Glodny, Bernhard

    2016-01-01

    The proximal urethral bulb in men is enlarged, surrounds the bulbous urethra, and extends dorsally towards the perineum. During intercourse engorgement takes place due to increased blood flow through the corpus spongiosum. Antegrade ejaculation is facilitated by contraction of the bulbospongiosus muscles during climax. Micturition during sexual stimulation is functionally inhibited. Supporting the bulb may indirectly facilitate continence in a certain subset of patients with postprostatectomy incontinence. During physical activity with increased abdominal pressure, reflex contraction of the pelvic floor muscles as well as the bulbospongiosus muscles occurs to support sphincter function and limit urinary incontinence. Operations to the prostate may weaken urinary sphincter function. It is hypothesized that the distal urinary sphincter may be supported indirectly by placing a hammock underneath the urethral bulb. During moments of physical stress the “cushion” of blood within the supported corpus spongiosum helps to increase the zone of coaptation within the sphincteric (membranous) urethra. This may lead to urinary continence in patients treated by a transobturator repositioning sling in patients with postprostatectomy incontinence. This paper describes the possible role of the urethral bulb in male urinary continence, including its function after retroluminal sling placement (AdVance, AdVance XP® Male Sling System, Minnetonka, USA). PMID:27022393

  15. EphB2 activity plays a pivotal role in pediatric medulloblastoma cell adhesion and invasion

    PubMed Central

    Sikkema, Arend H.; den Dunnen, Wilfred F.A.; Hulleman, Esther; van Vuurden, Dannis G.; Garcia-Manero, Guillermo; Yang, Hui; Scherpen, Frank J.G.; Kampen, Kim R.; Hoving, Eelco W.; Kamps, Willem A.; Diks, Sander H.; Peppelenbosch, Maikel P.; de Bont, Eveline S.J.M.

    2012-01-01

    Eph/ephrin signaling has been implicated in various types of key cancer-enhancing processes, like migration, proliferation, and angiogenesis. In medulloblastoma, invading tumor cells characteristically lead to early recurrence and a decreased prognosis. Based on kinase-activity profiling data published recently, we hypothesized a key role for the Eph/ephrin signaling system in medulloblastoma invasion. In primary medulloblastoma samples, a significantly higher expression of EphB2 and the ligand ephrin-B1 was observed compared with normal cerebellum. Furthermore, medulloblastoma cell lines showed high expression of EphA2, EphB2, and EphB4. Stimulation of medulloblastoma cells with ephrin-B1 resulted in a marked decrease in in vitro cell adhesion and an increase in the invasion capacity of cells expressing high levels of EphB2. The cell lines that showed an ephrin-B1–induced phenotype possessed increased levels of phosphorylated EphB2 and, to a lesser extent, EphB4 after stimulation. Knockdown of EphB2 expression by short hairpin RNA completely abolished ephrin ligand–induced effects on adhesion and migration. Analysis of signal transduction identified p38, Erk, and mTOR as downstream signaling mediators potentially inducing the ephrin-B1 phenotype. In conclusion, the observed deregulation of Eph/ephrin expression in medulloblastoma enhances the invasive phenotype, suggesting a potential role in local tumor cell invasion and the formation of metastases. PMID:22723427

  16. Hypothesis That Urethral Bulb (Corpus Spongiosum) Plays an Active Role in Male Urinary Continence.

    PubMed

    Rehder, Peter; Staudacher, Nina M; Schachtner, Joerg; Berger, Maria E; Schillfahrt, Florian; Hauser, Verena; Mueller, Raphael; Skradski, Viktor; Horninger, Wolfgang; Glodny, Bernhard

    2016-01-01

    The proximal urethral bulb in men is enlarged, surrounds the bulbous urethra, and extends dorsally towards the perineum. During intercourse engorgement takes place due to increased blood flow through the corpus spongiosum. Antegrade ejaculation is facilitated by contraction of the bulbospongiosus muscles during climax. Micturition during sexual stimulation is functionally inhibited. Supporting the bulb may indirectly facilitate continence in a certain subset of patients with postprostatectomy incontinence. During physical activity with increased abdominal pressure, reflex contraction of the pelvic floor muscles as well as the bulbospongiosus muscles occurs to support sphincter function and limit urinary incontinence. Operations to the prostate may weaken urinary sphincter function. It is hypothesized that the distal urinary sphincter may be supported indirectly by placing a hammock underneath the urethral bulb. During moments of physical stress the "cushion" of blood within the supported corpus spongiosum helps to increase the zone of coaptation within the sphincteric (membranous) urethra. This may lead to urinary continence in patients treated by a transobturator repositioning sling in patients with postprostatectomy incontinence. This paper describes the possible role of the urethral bulb in male urinary continence, including its function after retroluminal sling placement (AdVance, AdVance XP® Male Sling System, Minnetonka, USA). PMID:27022393

  17. Adult Play.

    ERIC Educational Resources Information Center

    Charles, John M.

    In its broadest context, play can be interpreted as any pleasurable use of discretionary time. Playfulness is an intrinsic feature of being human, and should be viewed in the light of a total lifestyle, not as an occurrence in an isolated time of life. Adult play appears to be an indefinable and controversial concept. A holistic approach should be…

  18. Wanna Play?

    ERIC Educational Resources Information Center

    Chenfeld, Mimi Brodsky

    2006-01-01

    In this article, the author talks about the importance of play in the lives of children and describes how games and imaginative play contribute to the development of children. From her decades-old collection of countless incidents demonstrating children's love for self-directed, informal, imaginative play, the author shares three incidents that…

  19. City Play.

    ERIC Educational Resources Information Center

    Dargan, Amanda; Zeitlin, Steve

    2000-01-01

    Today, fewer city blocks preserve the confidence of lifestyle and urban geography that sustain traditional games and outdoor play. Large groups of children choosing sides and organizing Red Rover games are no longer commonplace. Teachers must encourage free play; urban planners must build cities that are safe play havens. (MLH)

  20. Alteration/deficiency in activation-3 (Ada3) plays a critical role in maintaining genomic stability.

    PubMed

    Mirza, Sameer; Katafiasz, Bryan J; Kumar, Rakesh; Wang, Jun; Mohibi, Shakur; Jain, Smrati; Gurumurthy, Channabasavaiah Basavaraju; Pandita, Tej K; Dave, Bhavana J; Band, Hamid; Band, Vimla

    2012-11-15

    Cell cycle regulation and DNA repair following damage are essential for maintaining genome integrity. DNA damage activates checkpoints in order to repair damaged DNA prior to exit to the next phase of cell cycle. Recently, we have shown the role of Ada3, a component of various histone acetyltransferase complexes, in cell cycle regulation, and loss of Ada3 results in mouse embryonic lethality. Here, we used adenovirus-Cre-mediated Ada3 deletion in Ada3(fl/fl) mouse embryonic fibroblasts (MEFs) to assess the role of Ada3 in DNA damage response following exposure to ionizing radiation (IR). We report that Ada3 depletion was associated with increased levels of phospho-ATM (pATM), γH2AX, phospho-53BP1 (p53BP1) and phospho-RAD51 (pRAD51) in untreated cells; however, radiation response was intact in Ada3(-/-) cells. Notably, Ada3(-/-) cells exhibited a significant delay in disappearance of DNA damage foci for several critical proteins involved in the DNA repair process. Significantly, loss of Ada3 led to enhanced chromosomal aberrations, such as chromosome breaks, fragments, deletions and translocations, which further increased upon DNA damage. Notably, the total numbers of aberrations were more clearly observed in S-phase, as compared with G₁ or G₂ phases of cell cycle with IR. Lastly, comparison of DNA damage in Ada3(fl/fl) and Ada3(-/-) cells confirmed higher residual DNA damage in Ada3(-/-) cells, underscoring a critical role of Ada3 in the DNA repair process. Taken together, these findings provide evidence for a novel role for Ada3 in maintenance of the DNA repair process and genomic stability. PMID:23095635

  1. Listening to Learners.

    ERIC Educational Resources Information Center

    Ravenhall, Mark

    This booklet looks at the role of learner feedback in the quality improvement process. It suggests how adult and community learning (ACL) providers can adapt and improve their practice to meet the needs of learners in the changed policy context. Chapter 1 explores why providers should listen to learners and finds that listening to learners…

  2. Learner and Faculty Support

    ERIC Educational Resources Information Center

    Guan, Sharon; Stanford, Daniel

    2016-01-01

    This chapter identifies effective ways to address learner and faculty support. It introduces methods for building a successful learner support system by providing sufficient resources and proactively addressing learner motivation. It also addresses effective faculty support through institutional policies, resources, training, and course…

  3. Between the Social and the Selfish: Learner Autonomy in Online Environments

    ERIC Educational Resources Information Center

    Lewis, Tim

    2013-01-01

    This paper explores what it means to be an autonomous learner in an online social context. Using distinctions originally drawn by Jürgen Habermas, it argues that classic accounts of learner autonomy as teleological action are inadequate to explain learner activity in group settings. It points out that learners in such settings display attitudes…

  4. "Sharing Time" with Young Learners

    ERIC Educational Resources Information Center

    Yazigi, Rana; Seedhouse, Paul

    2005-01-01

    Although "Sharing Time" is a popular and widespread activity in English for Young Learners (L2) classrooms around the world, there have so far been no research studies of the interaction that is generated and its relationship to learning processes. The aims of this study were to find out how interaction is organized during "Sharing…

  5. Using Computers to Motivate Learners.

    ERIC Educational Resources Information Center

    Levesque, Jeri A.

    1989-01-01

    Maintains that the use of computers in the classroom produces motivated students, empowered learners, and increased literacy. Gives an example of the computer program "The Oregon Trail" in which students participate actively in a wagon train journey from Missouri to Oregon. Urges teachers to encourage students in their mastery of computer skills.…

  6. Staff Members as Lifelong Learners.

    ERIC Educational Resources Information Center

    Stern, Joanne V.

    Based on the assumption that all community college staff members should be lifelong learners, this paper outlines the purposes and principles underlying a quality staff development program and enumerates the elements, activities, incentives, and other considerations that are necessary for the program to be successful. First, the purposes of staff…

  7. Diabetes NetPLAY: A physical activity website and linked email counselling randomized intervention for individuals with type 2 diabetes.

    PubMed

    Liebreich, Tanis; Plotnikoff, Ronald C; Courneya, Kerry S; Boulé, Normand

    2009-01-01

    BACKGROUND -: This pilot study evaluated the feasibility (recruitment, retention, adherence and satisfaction) and preliminary efficacy of a 12-week website and email-linked counselling intervention on physical activity behaviour change in individuals with type 2 diabetes. METHODS -: A total of 49 individuals with type 2 diabetes (59% female, average age 54.1 years) were randomized to the Diabetes NetPLAY intervention or control condition. The intervention condition received information grounded in the Social Cognitive Theory (SCT), personalized weekly emails, an on-line logbook and message board. Key outcomes included physical activity behaviour and related cognition changes. The control condition was provided links to the Canadian Diabetes Association's Clinical Practice Guidelines for Physical Activity and Canada's Guide to Physical Activity. RESULTS -: Intervention participants indicated high levels of satisfaction for this mode of delivery and study results demonstrated the feasibility of web-based mediums for the delivery of physical activity information in this population. The intervention group demonstrated a significant improvement in total vigorous and moderate minutes of physical activity (p = 0.05) compared to the control group over the 12-week study. Among the SCT variables, behavioural capacity, showed a significant increase (p < 0.001) among intervention participants. CONCLUSION -: Web-based interventions for individuals with type 2 diabetes are feasible and show promise for improving positive physical activity outcomes. PMID:19327141

  8. NADPH Oxidase Dependent NLRP3 Inflammasome Activation Plays an Important Role in Lung Fibrosis by Multi-Walled Carbon Nanotubes

    PubMed Central

    Sun, Bingbing; Wang, Xiang; Ji, Zhaoxia; Wang, Meiying; Liao, Yu-Pei; Chang, Chong Hyun; Li, Ruibin; Zhang, Haiyuan; Nel, André E.; Xia, Tian

    2015-01-01

    The purpose of this communication is to elucidate the key role of NADPH oxidase in NLRP3 inflammasome activation and generation of pulmonary fibrosis by multi-walled carbon nanotubes (MWCNTs). Although it is known that oxidative stress plays a role in pulmonary fibrosis by single-walled CNTs, the role of specific sources of reactive oxygen species (ROS), including NADPH oxidase, in inflammasome activation remains to be clarified. In this study, three long aspect ratio (LAR) materials (MWCNTs, SWCNTs, and silver nanowires) are used to compare with spherical carbon black and silver nanoparticles for their ability to trigger oxygen burst activity and NLRP3 assembly. All LAR materials but not spherical nanoparticles induce robust NADPH oxidase activation and respiratory burst activity in THP-1 cells, which are blunted in p22phox deficient cells. NADPH oxidase is directly involved in lysosome damage by LAR materials, as demonstrated by decreased cathepsin B release and IL-1β production in p22phox deficient cells. Reduced respiratory burst activity and inflammasome activation are also observed in bone marrow-derived macrophages from p47phox deficient mice. Moreover, p47phox deficient mice have reduced IL-1β production and lung collagen deposition in response to MWCNTs. Lung fibrosis is also suppressed by N-acetyl-cysteine (NAC) in wild type animals exposed to MWCNTs. PMID:25581126

  9. Gelsolin-Like Domain 3 Plays Vital Roles in Regulating the Activities of the Lily Villin/Gelsolin/Fragmin Superfamily.

    PubMed

    Qian, Dong; Nan, Qiong; Yang, Yueming; Li, Hui; Zhou, Yuelong; Zhu, Jingen; Bai, Qifeng; Zhang, Pan; An, Lizhe; Xiang, Yun

    2015-01-01

    The villin/gelsolin/fragmin superfamily is a major group of Ca2+-dependent actin-binding proteins (ABPs) involved in various cellular processes. Members of this superfamily typically possess three or six tandem gelsolin-like (G) domains, and each domain plays a distinct role in actin filament dynamics. Although the activities of most G domains have been characterized, the biochemical function of the G3 domain remains poorly understood. In this study, we carefully compared the detailed biochemical activities of ABP29 (a new member of this family that contains the G1-G2 domains of lily ABP135) and ABP135G1-G3 (which contains the G1-G3 domains of lily ABP135). In the presence of high Ca2+ levels in vitro (200 and 10 μM), ABP135G1-G3 exhibited greater actin severing and/or depolymerization and nucleating activities than ABP29, and these proteins had similar actin capping activities. However, in the presence of low levels of Ca2+ (41 nM), ABP135G1-G3 had a weaker capping activity than ABP29. In addition, ABP29 inhibited F-actin depolymerization, as shown by dilution-mediated depolymerization assay, differing from the typical superfamily proteins. In contrast, ABP135G1-G3 accelerated F-actin depolymerization. All of these results demonstrate that the G3 domain plays specific roles in regulating the activities of the lily villin/gelsolin/fragmin superfamily proteins. PMID:26587673

  10. Gelsolin-Like Domain 3 Plays Vital Roles in Regulating the Activities of the Lily Villin/Gelsolin/Fragmin Superfamily

    PubMed Central

    Yang, Yueming; Li, Hui; Zhou, Yuelong; Zhu, Jingen; Bai, Qifeng; Zhang, Pan; An, Lizhe; Xiang, Yun

    2015-01-01

    The villin/gelsolin/fragmin superfamily is a major group of Ca2+-dependent actin-binding proteins (ABPs) involved in various cellular processes. Members of this superfamily typically possess three or six tandem gelsolin-like (G) domains, and each domain plays a distinct role in actin filament dynamics. Although the activities of most G domains have been characterized, the biochemical function of the G3 domain remains poorly understood. In this study, we carefully compared the detailed biochemical activities of ABP29 (a new member of this family that contains the G1-G2 domains of lily ABP135) and ABP135G1-G3 (which contains the G1-G3 domains of lily ABP135). In the presence of high Ca2+ levels in vitro (200 and 10 μM), ABP135G1-G3 exhibited greater actin severing and/or depolymerization and nucleating activities than ABP29, and these proteins had similar actin capping activities. However, in the presence of low levels of Ca2+ (41 nM), ABP135G1-G3 had a weaker capping activity than ABP29. In addition, ABP29 inhibited F-actin depolymerization, as shown by dilution-mediated depolymerization assay, differing from the typical superfamily proteins. In contrast, ABP135G1-G3 accelerated F-actin depolymerization. All of these results demonstrate that the G3 domain plays specific roles in regulating the activities of the lily villin/gelsolin/fragmin superfamily proteins. PMID:26587673

  11. Park design and children’s active play a micro-scale spatial analysis of intensity of play in Olmsted’s Delaware Park

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This paper offers a micro-scale exploration of the role of park design on intensity of physical activity among youth. The actual, unstructured use of a park - specifically, Delaware Park, an Olmsted-designed park in Buffalo, New York - by 94 children was objectively observed and analyzed using Geog...

  12. Evidence of active role played by the nonmagnetic element Sr in magnetostructural coupling in SrRuO[subscript 3

    SciTech Connect

    Lahiri, Debdutta; Shibata, T.; Chattopadhyay, S.; Kanungo, Sudipta; Saha-Dasgupta, T.; Singh, R.S.; Sharma, Surinder M.; Maiti, Kalobaran

    2010-11-12

    We study the magnetic transition in SrRuO{sub 3}, the only itinerant 4d ferromagnet, employing x-ray absorption fine structure study and state-of-the-art band-structure calculations. Both experimental and theoretical results reveal an unusual evolution of the local structural parameters around the spectator element, Sr, across the magnetic transition. Interestingly, such evolution of the Sr-related bonds nucleate at a temperature, T*, higher than the magnetic transition temperature, indicating the presence of a precursor effect. Contrary to common belief, these results point to the active role played by the Sr ion in the magnetostructural coupling present in this compound.

  13. Sphingosine kinase 1 dependent protein kinase C-δ activation plays an important role in acute liver failure in mice

    PubMed Central

    Lei, Yan-Chang; Yang, Ling-Ling; Li, Wen; Luo, Pan

    2015-01-01

    AIM: To investigate the role of protein kinase C (PKC)-δ activation in the pathogenesis of acute liver failure (ALF) in a well-characterized mouse model of D-galactosamine (D-GalN)/lipopolysaccharide (LPS)-induced ALF. METHODS: BALB/c mice were randomly assigned to five groups, and ALF was induced in mice by intraperitoneal injection of D-GaIN (600 mg/kg) and LPS (10 μg/kg). Kaplan-Meier method was used for survival analysis. Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels at different time points within one week were determined using a multiparameteric analyzer. Serum levels of high-mobility group box 1 (HMGB1), tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, and IL-10 as well as nuclear factor (NF)-κB activity were determined by enzyme-linked immunosorbent assay. Hepatic morphological changes at 36 h after ALF induction were assessed by hematoxylin and eosin staining. Expression of PKC-δ in liver tissue and peripheral blood mononuclear cells (PBMCs) was analyzed by Western blot. RESULTS: The expression and activation of PKC-δ were up-regulated in liver tissue and PBMCs of mice with D-GalN/LPS-induced ALF. Inhibition of PKC-δ activation with rottlerin significantly increased the survival rates and decreased serum ALT/AST levels at 6, 12 and 24 h compared with the control group (P < 0.001). Rottlerin treatment also significantly decreased serum levels of HMGB1 at 6, 12, and 24 h, TNF-α, IL-6 and IL-1 β at 12 h compared with the control group (P < 0.01). The inflammatory cell infiltration and necrosis in liver tissue were also decreased in the rottlerin treatment group. Furthermore, sphingosine kinase 1 (SphK1) dependent PKC-δ activation played an important role in promoting NF-κB activation and inflammatory cytokine production in ALF. CONCLUSION: SphK1 dependent PKC-δ activation plays an important role in promoting NF-κB activation and inflammatory response in ALF, and inhibition of PKC-δ activation might be

  14. Turnip vein clearing virus movement protein nuclear activity: Do Tobamovirus movement proteins play a role in immune response suppression?

    PubMed Central

    Levy, Amit

    2015-01-01

    Plant viruses' cell-to-cell movement requires the function of virally encoded movement proteins (MPs). The Tobamovirus, Tobacco mosaic virus (TMV) has served as the model virus to study the activities of single MPs. However, since TMV does not infect the model plant Arabidopsis thaliana I have used a related Tobamovirus, Turnip vein-clearing virus (TVCV). I recently showed that, despite belonging to the same genus, the behavior of the 2 viruses MPs differ significantly during infection. Most notably, MPTVCV, but not MPTMV, targets the nucleus and induces the formation of F actin-containing filaments that associate with chromatin. Mutational analyses showed that nuclear localization of MPTVCV was necessary for TVCV local and systemic infection in both Nicotiana benthamiana and Arabidopsis. In this addendum, I propose possible targets for the MPTVCV nuclear activity, and suggest viewing MPs as viral effector-like proteins, playing a role in the inhibition of plant defense. PMID:26237173

  15. The Physics of a Volcanic System: What is the Actual Role Played by Tectonic Setting in Controlling Volcanic Activity?

    NASA Astrophysics Data System (ADS)

    Canon-Tapia, E.

    2005-12-01

    Modern text-books commonly explain volcanic activity as a direct consequence of plate tectonics, overlooking the different scales characteristic of both types of processes. By acknowledging such differences, however, it is possible to envisage a model of a volcanic system that is based in the same principles of hydrostatics established by Blaise Pascal over 300 yrs ago. Such principles allow us to estimate the local conditions required for the occurrence of volcanism at a given location highlighting the importance of the rock strength and the density difference between melt and its surroundings. This model shows that the minimum thickness of the zone of partial melting in the mantle (or seismically defined Low Velocity Zone) that is required to feed volcanic activity might range from 5 to over 100 km, but also that under certain circumstances a rock strength < 200 MPa may suffice to keep magma trapped at depth whereas in other cases a strength > 600 MPa will not suffice to stop magma ascent resulting in volcanic activity at the surface. Consequently, the model of volcanism developed here explains why is that a given LVZ may lead to volcanic activity in some places whereas a completely identical LVZ may not result in volcanic activity in a different location. Consequently, this model provides a general framework that allows us to better understand the actual role played by tectonic setting in controlling volcanism at a planetary scale.

  16. The Teaching Methodology of Arabic Speaking Skills: Learners' Perspectives

    ERIC Educational Resources Information Center

    Haron, Sueraya Che

    2013-01-01

    Teaching methodology plays an important role in transmitting knowledge and skills to learners. The effectiveness of both knowledge and skills depends greatly on the methodology used. This paper describes a study to investigate the learners' perspectives on the teaching methodology used by the teachers at the Centre for Foundation Studies,…

  17. Learning Words for Life: Promoting Vocabulary in Dual Language Learners

    ERIC Educational Resources Information Center

    Gillanders, Cristina; Castro, Dina C.; Franco, Ximena

    2014-01-01

    Vocabulary development plays a critical role in young dual language learners' success in school. As teachers become aware of how they use language in the classroom, systematically teach specific words in a variety of ways, and learn about dual language learners' level of English acquisition and sociocultural experiences, they can help…

  18. Shadow Play

    ERIC Educational Resources Information Center

    Trundle, Kathy Cabe; Hilson, Margilee P.

    2012-01-01

    A bunny rabbit playfully hops across the wall. Then hands realign and fingers shift to make a hawk soar toward the ceiling. Most children have enjoyed the delightful experience of playing with shadow puppets. The authors build on this natural curiosity to help students link shadows to complex astronomical concepts such as seasons. The…

  19. Reciprocal Teaching and Emotional Intelligence: A Study of Iranian EFL Learners' Reading Comprehension

    ERIC Educational Resources Information Center

    Izadi, Mehri; Nowrouzi, Hossein

    2016-01-01

    The present study aimed at exploring the effect of reciprocal reading strategies instruction on reading comprehension of EFL learners. Emotional intelligence, another variable of interest, was assessed to indicate whether it plays a role in learners' comprehension. In a pre- and post-test study, forty-two learners went through a reciprocal reading…

  20. Effects of Negotiated Interaction on Mongolian-Nationality EFL Learners' Spoken Output

    ERIC Educational Resources Information Center

    Li, Xueping

    2012-01-01

    The present study examines the effect of negotiated interaction on Mongolian-nationality EFL learners' spoken production, focusing on the teacher-learner interaction in a story-telling task. The study supports the hypothesis that interaction plays a facilitating role in language development for learners. Quantitative analysis shows that Mongolian…

  1. Notch and Wnt/β-catenin signaling pathway play important roles in activating liver cancer stem cells.

    PubMed

    Wang, Ronghua; Sun, Qian; Wang, Peng; Liu, Man; Xiong, Si; Luo, Jing; Huang, Hai; Du, Qiang; Geller, David A; Cheng, Bin

    2016-02-01

    Human hepatocellular carcinoma (HCC) is driven and maintained by liver cancer stem cells (LCSCs) that display stem cell properties. These LCSCs are promoted by the intersecting of Notch and Wnt/β-Catenin signaling pathways. In this study, we demonstrate that LCSCs with markers CD90, CD24, CD13, and CD133 possess stem properties of self-renewal and tumorigenicity in NOD/SCID mice. The increased expression of these markers was correlated with advanced disease stage, larger tumors, and worse overall survival in 61 HCC cases. We also found that both Notch and Wnt/β-catenin signaling pathways played important roles in increasing the stem-ness characteristics of LCSCs. Our data suggested that Notch1 was downstream of Wnt/β-catenin. The active form of Notch1 intracellular domain (NICD) expression depended on Wnt/β-catenin pathway activation. Moreover, Notch1 negatively contributed to Wnt/β-catenin signaling modulation. Knock down of Notch1 with lentivirus N1ShRNA up-regulated the active form of β-catenin. Ectopic expression of NICD with LV-Notch1 in LCSCs attenuated β-catenin/TCF dependent luciferase activity significantly. In addition, there was a non-proteasome mediated feedback loop between Notch1 and Wnt/β-catenin signaling in LCSCs. The central role of Notch and the Wnt/β-catenin signaling pathway in LCSCs may provide an attractive therapeutic strategy against HCC. PMID:26735577

  2. Development of semantic processes for academic language in foundation phase EAL learners.

    PubMed

    Meirim, Giselle; Jordaan, Heila; Kallenbach, Amy; Rijhumal, Meera

    2010-12-01

    It is widely acknowledged that language competence is central to educational success, primarily because literacy is inherently a language-based activity. Vocabulary knowledge specifically plays an important role in the acquisition of reading comprehension skills. Language in education practice in South Africa is currently highly controversial, as the implementation of home language or bilingual instruction policies has not been achieved in many schools. The aim of this study was to investigate the development of language skills in foundation phase English Additional Language (EAL) learners attending schools where English is the language of learning and teaching. A 3-year longitudinal investigation of the acquisition of some of the processes underlying language for academic purposes was undertaken using the semantics subtests of the Developmental Evaluation of Language Variation Criterion Referenced Edition (Seymour, Roeper & De Villiers, 2003). The results indicated that the majority of EAL learners improved with increased exposure to English in the academic environment and by the time they were in grade 3, were performing at a higher level than English First Language learners in grade 2. However, the effects of this protracted period of development on literacy attainment should be investigated. The significant individual variation in the learners' performance has implications for assessment and instruction of EAL learners and for the collaborative role of teachers and speech language therapists in the education system. PMID:21329265

  3. Endocardial focal activation originating from Purkinje fibers plays a role in the maintenance of long duration ventricular fibrillation

    PubMed Central

    Lin, Changjian; Jin, Qi; Zhang, Ning; Zhou, Jian; Pang, Yang; Xin, Yangxun; Liu, Shaohua; Wu, Qiong; Wu, Liqun

    2014-01-01

    activation of subendocardial PFs. This mechanism may play an important role in the maintenance of LDVF. PMID:24778098

  4. Enhanced nitric oxide and cyclic GMP formation plays a role in the anti-platelet activity of simvastatin

    PubMed Central

    Chou, T-C; Lin, Y-F; Wu, W-C; Chu, K-M

    2008-01-01

    Background and purpose: It has been found that 3-hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) exert various vascular protective effects, beyond their cholesterol-lowering property, including inhibition of platelet-dependent thrombus formation. The objective of the present study was to determine whether the nitric oxide (NO)/cyclic GMP-mediated processes in platelets contribute to the anti-aggregatory activity of simvastatin. Experimental approach: After rabbit platelets were incubated with simvastatin for 5 min, aggregation was induced and the platelet aggregation, nitric oxide synthase activity, guanylyl cyclase activity, NO and cyclic GMP formation were measured appropriately. Key results: Treatment with simvastatin concentration-dependently inhibited platelet aggregation induced by collagen or arachidonic acid with an IC50 range of 52–158 μM. We also demonstrated that simvastatin (20–80 μM) concentration-dependently further enhanced collagen-induced NO and cyclic GMP formation through increasing NOS activity (from 2.64±0.12 to 3.52±0.21–5.10±0.14 μmol min−1 mg protein−1) and guanylyl cyclase activity (from 142.9±7.2 to 163.5±17.5–283.8±19.5 pmol min−1 mg protein−1) in the platelets. On the contrary, inhibition of platelet aggregation by simvastatin was markedly attenuated (by about 50%) by addition of a nitric oxide synthase inhibitor, a NO scavenger or a NO-sensitive guanylyl cyclase inhibitor. The anti-aggregatory effects of simvastatin were significantly increased by addition of a selective inhibitor of cyclic GMP phosphodiesterase. Conclusions and implications: Our findings indicate that enhancement of a NO/cyclic GMP-mediated process plays an important role in the anti-aggregatory activity of simvastatin. PMID:18264124

  5. Modeling Learner Variability in CALL

    ERIC Educational Resources Information Center

    Heift, Trude

    2008-01-01

    This article describes challenges and benefits of modeling learner variability in Computer-Assisted Language Learning. We discuss the learner model of "E-Tutor," a learner model that addresses learner variability by focusing on certain aspects and/or features of the learner's interlanguage. Moreover, we introduce the concept of phrase descriptors,…

  6. Just watching the game ain't enough: striatal fMRI reward responses to successes and failures in a video game during active and vicarious playing

    PubMed Central

    Kätsyri, Jari; Hari, Riitta; Ravaja, Niklas; Nummenmaa, Lauri

    2013-01-01

    Although the multimodal stimulation provided by modern audiovisual video games is pleasing by itself, the rewarding nature of video game playing depends critically also on the players' active engagement in the gameplay. The extent to which active engagement influences dopaminergic brain reward circuit responses remains unsettled. Here we show that striatal reward circuit responses elicited by successes (wins) and failures (losses) in a video game are stronger during active than vicarious gameplay. Eleven healthy males both played a competitive first-person tank shooter game (active playing) and watched a pre-recorded gameplay video (vicarious playing) while their hemodynamic brain activation was measured with 3-tesla functional magnetic resonance imaging (fMRI). Wins and losses were paired with symmetrical monetary rewards and punishments during active and vicarious playing so that the external reward context remained identical during both conditions. Brain activation was stronger in the orbitomedial prefrontal cortex (omPFC) during winning than losing, both during active and vicarious playing. In contrast, both wins and losses suppressed activations in the midbrain and striatum during active playing; however, the striatal suppression, particularly in the anterior putamen, was more pronounced during loss than win events. Sensorimotor confounds related to joystick movements did not account for the results. Self-ratings indicated losing to be more unpleasant during active than vicarious playing. Our findings demonstrate striatum to be selectively sensitive to self-acquired rewards, in contrast to frontal components of the reward circuit that process both self-acquired and passively received rewards. We propose that the striatal responses to repeated acquisition of rewards that are contingent on game related successes contribute to the motivational pull of video-game playing. PMID:23781195

  7. Improving Learners' Research Process Skills

    NASA Astrophysics Data System (ADS)

    Quan, T. K.; Hunter, L.; Kluger-Bell, B.; Seagroves, S.

    2010-12-01

    The Professional Development Program (PDP) supports participants as they design inquiry activities that help learners improve their research process skills. These skills include the cognitive or reasoning skills that scientists and engineers use while doing research; for example, making a testable hypothesis, coordinating results from multiple experiments, or identifying and evaluating tradeoffs. Past work in the PDP indicated that additional support was needed to help participants design instructional activities that would teach these important skills. A new workshop was therefore developed for the 2009 PDP cycle, entitled "Improving Learners' Process Skills." In this workshop, participants worked in small groups to define specific science and engineering skills found in four past PDP activity designs. Participants distinguished between "simple tasks" and "authentic inquiry" activities that learners could perform as demonstration of the skill. Through this new workshop, participants were able to explicitly discuss ways in which individual process skills are unique or inter-related. In addition, by identifying a "simple task," participants were able to pinpoint areas in which their own designs could be improved to better focus on authentic inquiry tasks. In 2010, the workshop was slightly modified to help participants reconnect the research process skills with the activity content. In addition, the idea of using generic and context-specific scaffolds was also introduced. To make the participants feel like they were contributing to the PDP community, four activity designs actively being worked on in the 2010 cycle were used. Based on participant feedback, this "Improving Learners' Process Skills" workshop should be strongly considered for future returning participants.

  8. Play: early and eternal.

    PubMed Central

    Mears, C E; Harlow, H F

    1975-01-01

    A systematic 12-week investigation of development of play behavior was conducted with eight socially reared rhesus monkey infants. A new, basic and primary play form termed self-motion play or peragration was identified and examined. This behavior follows a human model which includes a wide range of pleasurable activities involving motion of the body through space, e.g., rocking, swinging, running, leaping, and water or snow skiing. It can be argued that self-motion play is the initial primate play form and because of its persistence constitutes a reinforcing agent for maintaining many complex patterns and even pastimes. Monkey self-motion play in the present study was divided into five separate patterns in order to compare the relative importance of social and individual peragration play, the role of apparatus and the overall developmental relationships between the different individual and social self-motion play patterns. The data showed that from 90 to 180 days of age self-motion play was independent of other forms of play, that individual self-motion play appeared earlier and with significantly greater increases in frequency than did social self-motion play, and that apparatus was a necessary component for significant increases in social self-motion play. Other findings were that self-motion play existed independent of locomotion and, though initiated by exploration, was separate from it. Therapeutic implications of self-motion play were discussed. Images PMID:1057178

  9. Phosphatidylinositol 3-Kinase Plays a Vital Role in Regulation of Rice Seed Vigor via Altering NADPH Oxidase Activity

    PubMed Central

    Liu, Jian; Zhou, Jun; Xing, Da

    2012-01-01

    Phosphatidylinositol 3-kinase (PI3K) has been reported to be important in normal plant growth and stress responses. In this study, it was verified that PI3K played a vital role in rice seed germination through regulating NADPH oxidase activity. Suppression of PI3K activity by inhibitors wortmannin or LY294002 could abate the reactive oxygen species (ROS) formation, which resulted in disturbance to the seed germination. And then, the signal cascades that PI3K promoted the ROS liberation was also evaluated. Diphenylene iodonium (DPI), an NADPH oxidase inhibitor, suppressed most of ROS generation in rice seed germination, which suggested that NADPH oxidase was the main source of ROS in this process. Pharmacological experiment and RT-PCR demonstrated that PI3K promoted the expression of Os rboh9. Moreover, functional analysis by native PAGE and the measurement of the 2, 3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazo-lium-5- carboxanilide (XTT) formazan concentration both showed that PI3K promoted the activity of NADPH oxidase. Furthermore, the western blot analysis of OsRac-1 demonstrated that the translocation of Rac-1 from cytoplasm to plasma membrane, which was known as a key factor in the assembly of NADPH oxidase, was suppressed by treatment with PI3K inhibitors, resulting in the decreased activity of NADPH oxidase. Taken together, these data favored the novel conclusion that PI3K regulated NADPH oxidase activity through modulating the recruitment of Rac-1 to plasma membrane and accelerated the process of rice seed germination. PMID:22448275

  10. Park characteristics, use, and physical activity: A review of studies using SOPARC (System for Observing Play and Recreation in Communities).

    PubMed

    Evenson, Kelly R; Jones, Sydney A; Holliday, Katelyn M; Cohen, Deborah A; McKenzie, Thomas L

    2016-05-01

    The System for Observing Play and Recreation in Communities (SOPARC) can obtain information on park users and their physical activity using momentary time sampling. We conducted a literature review of studies using the SOPARC tool to describe the observational methods of each study, and to extract public park use overall and by demographics and physical activity levels. We searched PubMed, Embase, and SPORTDiscus for full-length observational studies published in English in peer-reviewed journals through 2014. Twenty-four studies from 34 articles were included. The number of parks observed per study ranged from 3 to 50. Most studies observed parks during one season. The number of days parks were observed ranged from 1 to 16, with 16 studies observing 5 or more days. All studies included at least one weekday and all but two included at least one weekend day. Parks were observed from 1 to 14times/day, with most studies observing at least 4 times/day. All studies included both morning and afternoon observations, with one exception. There was a wide range of park users (mean 1.0 to 152.6 people/park/observation period), with typically more males than females visiting parks and older adults less than other age groups. Park user physical activity levels varied greatly across studies, with youths generally more active than adults and younger children more active than adolescents. SOPARC was adapted to numerous settings and these review results can be used to improve future studies using the tool, demonstrate ways to compare park data, and inform park promotions and programming. PMID:26946365

  11. Learner Agency

    ERIC Educational Resources Information Center

    Mick, Carola

    2011-01-01

    This article presents first results of an ethnographic research project in a Luxembourgish primary school that accompanied the development of a school project by children from the fifth grade. Analysing the data children themselves collected with Kodak Zi8 cameras in order to document their project activities, it investigates their possibilities…

  12. Mother and Toddler Activity in the Zone of Proximal Development for Pretend Play as a Predictor of Higher Child IQ

    ERIC Educational Resources Information Center

    Morrissey, Anne-Marie; Brown, P. Margaret

    2009-01-01

    This study investigated the pretend play of mother-toddler dyads in relation to later child IQ. Twenty-one toddlers were videotaped in monthly play sessions with their mothers, from age 8 to 17 months, and later assessed at 5 years of age on the Stanford-Binet IV. Children's and mothers' pretend play levels and frequencies were measured using…

  13. Mothers and Fathers at Play with Their Children with Down Syndrome: Influence on Child Exploratory and Symbolic Activity

    ERIC Educational Resources Information Center

    De Falco, Simona; Esposito, Gianluca; Venuti, Paola; Bornstein, Marc H.

    2010-01-01

    Background: Through play children exercise their emerging mental abilities, and for their part, when in collaborative play, caregivers often adjust their behaviours to assist their children's progress. In this study, we focused on comparisons between play of Down Syndrome (DS) children with their two parents as well as on comparisons between the…

  14. Teachers' Perceptions of Boys' and Girls' Shared Activities in the School Context: Towards a Theory of Collaborative Play

    ERIC Educational Resources Information Center

    Hyvonen, Pirkko

    2008-01-01

    The Finnish educational system and curricula lay emphasis on play, collaboration and equality. Modern educational practices allow the learning environment to be enlarged from indoor classrooms to outdoor playful learning environments (PLEs). PLEs have been constructed in schoolyards in Finland with the goal of increasing learning through play in…

  15. Brain Network Activation as a Novel Biomarker for the Return-to-Play Pathway Following Sport-Related Brain Injury.

    PubMed

    Kiefer, Adam W; Barber Foss, Kim; Reches, Amit; Gadd, Brooke; Gordon, Michael; Rushford, Ken; Laufer, Ilan; Weiss, Michal; Myer, Gregory D

    2015-01-01

    Children and adolescent athletes are at a higher risk for concussion than adults, and also experience longer recovery times and increased associated symptoms. It has also recently been demonstrated that multiple, seemingly mild concussions may result in exacerbated and prolonged neurological deficits. Objective assessments and return-to-play criteria are needed to reduce risk and morbidity associated with concussive events in these populations. Recent research has pushed to study the use of electroencephalography as an objective measure of brain injury. In the present case study, we present a novel approach that examines event-related potentials via a brain network activation (BNA) analysis as a biomarker of concussion and recovery. Specifically, changes in BNA scores, as indexed through this approach, offer a potential indicator of neurological health as the BNA assessment qualitatively and quantitatively indexes the network dynamics associated with brain injury. Objective tools, such as these support accurate and efficient assessment of brain injury and may offer a useful step in categorizing the temporal and spatial changes in brain activity following concussive blows, as well as the functional connectivity of brain networks, associated with concussion. PMID:26635720

  16. Set7 mediated Gli3 methylation plays a positive role in the activation of Sonic Hedgehog pathway in mammals

    PubMed Central

    Fu, Lin; Wu, Hailong; Cheng, Steven Y; Gao, Daming; Zhang, Lei; Zhao, Yun

    2016-01-01

    Hedgehog signaling plays very important roles in development and cancers. Vertebrates have three transcriptional factors, Gli1, Gli2 and Gli3. Among them, Gli3 is a very special transcriptional factor which closely resembles Cubitus interruptus (Ci, in Drosophila) structurally and functionally as a ‘double agent’ for Shh target gene expression. Here we show that Gli3 full-length, but not the truncated form, can be methylated at K436 and K595. This methylation is specifically catalyzed by Set7, a lysine methyltransferase (KMT). Methylation at K436 and K595 respectively increases the stability and DNA binding ability of Gli3, resulting in an enhancement of Shh signaling activation. Furthermore, functional experiments indicate that the Gli3 methylation contributes to the tumor growth and metastasis in non-small cell lung cancer in vitro and in vivo. Therefore, we propose that Set7 mediated methylation is a novel PTM of Gli3, which positively regulates the transactivity of Gli3 and the activation of Shh signaling. DOI: http://dx.doi.org/10.7554/eLife.15690.001 PMID:27146893

  17. The linker region plays a regulatory role in assembly and activity of the Vps4 AAA ATPase.

    PubMed

    Shestakova, Anna; Curtiss, Matt; Davies, Brian A; Katzmann, David J; Babst, Markus

    2013-09-13

    The AAA-type ATPase Vps4 functions with components of the ESCRT (endosomal sorting complex required for transport) machinery in membrane fission events that are essential for endosomal maturation, cytokinesis, and the formation of retroviruses. A key step in these events is the assembly of monomeric Vps4 into the active ATPase complex, which is aided in part by binding of Vps4 via its N-terminal MIT (microtubule interacting and trafficking) domain to its substrate ESCRT-III. We found that the 40-amino acid linker region between the MIT and the ATPase domain of Vps4 is not required for proper function but plays a role in regulating Vps4 assembly and ATPase activity. Deletion of the linker is expected to bring the MIT domains into close proximity to the central pore of the Vps4 complex. We propose that this localization of the MIT domain in linker-deleted Vps4 mimics a repositioning of the MIT domain normally caused by binding of Vps4 to ESCRT-III. This structure would allow the Vps4 complex to engage ESCRT-III subunits with both the pore and the MIT domain simultaneously, which might be essential for the ATP-driven disassembly of ESCRT-III. PMID:23913684

  18. Set7 mediated Gli3 methylation plays a positive role in the activation of Sonic Hedgehog pathway in mammals.

    PubMed

    Fu, Lin; Wu, Hailong; Cheng, Steven Y; Gao, Daming; Zhang, Lei; Zhao, Yun

    2016-01-01

    Hedgehog signaling plays very important roles in development and cancers. Vertebrates have three transcriptional factors, Gli1, Gli2 and Gli3. Among them, Gli3 is a very special transcriptional factor which closely resembles Cubitus interruptus (Ci, in Drosophila) structurally and functionally as a 'double agent' for Shh target gene expression. Here we show that Gli3 full-length, but not the truncated form, can be methylated at K436 and K595. This methylation is specifically catalyzed by Set7, a lysine methyltransferase (KMT). Methylation at K436 and K595 respectively increases the stability and DNA binding ability of Gli3, resulting in an enhancement of Shh signaling activation. Furthermore, functional experiments indicate that the Gli3 methylation contributes to the tumor growth and metastasis in non-small cell lung cancer in vitro and in vivo. Therefore, we propose that Set7 mediated methylation is a novel PTM of Gli3, which positively regulates the transactivity of Gli3 and the activation of Shh signaling. PMID:27146893

  19. Late Quaternary high resolution sequence stratigraphy of an active rift, the Sperchios Basin, Greece: An analogue for subtle stratigraphic plays

    SciTech Connect

    Eliet, P.P.; Gawthorpe, R.L.

    1996-12-31

    The Sperchios Basin is an active asymmetric graben, bounded to the south by a major border fault system with major fault segments typically 20-30 km long. The basin is dominated by a major axial fluvio-deltaic system which enters the partially enclosed Maliakos Gulf to the east. Lateral sourced depositional systems within the basin comprise hanging-wall and footwall-derived alluvial fans and a narrow coastal plain along the footwall scarp bordering the Maliakos Gulf. High resolution seismic data from the Maliakos Gulf reveals three late Quaternary progradational parasequences sourced from axial and lateral depositional systems, with a regional late-Pleistocene transgressive surface dated at circa. 10 ka BP within the Maliakos Gulf. Differential subsidence of the late Pleistocene transgressive surface indicates marked variation in subsidence from 2.4 m ka{sup -1} at fault segment centers to 0.8 m ka{sup -1} at segment boundaries. The geometry and internal variability of each parasequence is controlled by the interplay of the local accommodation development and fluctuations in sediment supply and climatic conditions. The Sperchios Rift provides a modem analogue for subtle stratigraphic plays within ancient extensional basins. The study of controls on sediment source and transport patterns within active rifts has refined our appreciation of the controls on potential reservoir distribution and geometries.

  20. Late Quaternary high resolution sequence stratigraphy of an active rift, the Sperchios Basin, Greece: An analogue for subtle stratigraphic plays

    SciTech Connect

    Eliet, P.P. ); Gawthorpe, R.L. )

    1996-01-01

    The Sperchios Basin is an active asymmetric graben, bounded to the south by a major border fault system with major fault segments typically 20-30 km long. The basin is dominated by a major axial fluvio-deltaic system which enters the partially enclosed Maliakos Gulf to the east. Lateral sourced depositional systems within the basin comprise hanging-wall and footwall-derived alluvial fans and a narrow coastal plain along the footwall scarp bordering the Maliakos Gulf. High resolution seismic data from the Maliakos Gulf reveals three late Quaternary progradational parasequences sourced from axial and lateral depositional systems, with a regional late-Pleistocene transgressive surface dated at circa. 10 ka BP within the Maliakos Gulf. Differential subsidence of the late Pleistocene transgressive surface indicates marked variation in subsidence from 2.4 m ka[sup -1] at fault segment centers to 0.8 m ka[sup -1] at segment boundaries. The geometry and internal variability of each parasequence is controlled by the interplay of the local accommodation development and fluctuations in sediment supply and climatic conditions. The Sperchios Rift provides a modem analogue for subtle stratigraphic plays within ancient extensional basins. The study of controls on sediment source and transport patterns within active rifts has refined our appreciation of the controls on potential reservoir distribution and geometries.

  1. Valued Life Activity Disability Played a Significant Role in Self-Rated Health among Adults with Chronic Health Conditions

    PubMed Central

    Katz, Patricia; Morris, Anne; Gregorich, Steve; Yazdany, Jinoos; Eisner, Mark; Yelin, Edward; Blanc, Paul

    2009-01-01

    Objective Because self-rated health (SRH) is strongly associated with health outcomes, it is important to identify factors that individuals take into account when they assess their health. We examined the role of valued life activities (VLAs), the wide range of activities deemed to be important to individuals, in SRH assessments. Study Design and Setting Data were from 3 cohort studies of individuals with different chronic conditions – rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and chronic obstructive pulmonary disease (COPD). Each cohort’s data were collected through structured telephone interviews. Logistic regression analyses identified factors associated with ratings of fair/poor SRH. All analyses included sociodemographic characteristics, general and disease-specific health-related factors, and general measures of physical functioning. Results Substantial portions of each group rated their health as fair/poor (RA 37%, SLE 47%, COPD 40%). In each group, VLA disability was strongly associated with fair/poor health (RA: OR=4.44 [1.86,10.62]; SLE: OR=3.60 [2.10,6.16]; COPD: OR=2.76 [1.30,5.85], even after accounting for covariates. Conclusion VLA disability appears to play a substantial role in individual perceptions of health, over and above other measures of health status, disease symptoms, and general physical functioning. PMID:18722089

  2. Differentiating for Young, Curious, and Imaginative Learners

    ERIC Educational Resources Information Center

    Smutny, Joan Franklin

    2012-01-01

    To meet the needs of young gifted and talented learners, teachers need the flexibility to respond to individual needs without the stress of extra planning and preparation. Certainly, some planning comes into play. Engaging the gifts and interests of these students in a way that is also reasonable presents a unique challenge. One of the most…

  3. Fairness in Assessment of English Learners

    ERIC Educational Resources Information Center

    Abedi, Jamal; Levine, Harold G.

    2013-01-01

    English language learners (ELLs) face a challenging academic future in learning a new language while simultaneously mastering content in the language they may be struggling to learn. Assessment plays an extremely important role in the academic careers of ELL students, perhaps more so than for native speakers of English. Major changes and…

  4. Input Generation by Young Second Language Learners.

    ERIC Educational Resources Information Center

    Cathcart-Strong, Ruth L.

    1986-01-01

    Examined spontaneous communicative acts (requests for information, calls for attention, intention statements, etc.) of a group of young second-language learners and their native-speaker interlocutors in three play situations. Results showed that, while the response rate to some types of utterances was predictable, others did not generate the…

  5. Relationships between match activities and peak power output and Creatine Kinase responses to professional reserve team soccer match-play.

    PubMed

    Russell, M; Sparkes, W; Northeast, J; Cook, C J; Bracken, R M; Kilduff, L P

    2016-02-01

    The specific movement demands of soccer that are linked to post-match recovery and readiness to train are unclear. Therefore, we examined the relationship between Global Positioning System (GPS) variables and the change (Δ; from baseline) in Creatine Kinase (CK) concentrations and peak power output (PPO; during the countermovement jump) at 24h and 48h post-match. Fifteen English Premier League reserve team players were examined over 1-4 matches. Measurements of CK and PPO were taken before (24h prior to match-play) and after (+24h and +48h) each game during which movement demands were quantified using 10Hz GPS data. High intensity distance covered (r=0.386, p=0.029; r=-0.349; p=0.050), high intensity distance covered⋅min(-1) (r=0.365, p=0.040; r=-0.364, p=0.040), high speed running distance (r=0.363, p=0.041; r=-0.360, p=0.043) and the number of sprints⋅min(-1) (r=0.410, p=0.020; r=-0.368, p=0.038) were significantly related to ΔCK and ΔPPO at +24h post-match, respectively. No relationships were observed between any match variables and ΔCK and ΔPPO after +48h of recovery. These findings highlight that high intensity match activities are related to ΔCK and ΔPPO in the 24h, but not 48h, following soccer match-play. Such information is likely of interest to those responsible for the design of soccer player's training schedules in the days following a match. PMID:26615476

  6. Clay Play

    ERIC Educational Resources Information Center

    Rogers, Liz; Steffan, Dana

    2009-01-01

    This article describes how to use clay as a potential material for young children to explore. As teachers, the authors find that their dialogue about the potential of clay as a learning medium raises many questions: (1) What makes clay so enticing? (2) Why are teachers noticing different play and conversation around the clay table as compared to…

  7. Playing Teacher.

    ERIC Educational Resources Information Center

    Gilbert, Juan E.

    The acceptance of animation technologies is increasing. Video games, such as Sony PlayStation (SONY, 2002), have become part of the culture for young people from kindergarten through undergraduate school. Animation technologies have been implemented into educational systems in the form of animated pedagogical agents (Johnson, 2000). The research…

  8. Game playing.

    PubMed

    Rosin, Christopher D

    2014-03-01

    Game playing has been a core domain of artificial intelligence research since the beginnings of the field. Game playing provides clearly defined arenas within which computational approaches can be readily compared to human expertise through head-to-head competition and other benchmarks. Game playing research has identified several simple core algorithms that provide successful foundations, with development focused on the challenges of defeating human experts in specific games. Key developments include minimax search in chess, machine learning from self-play in backgammon, and Monte Carlo tree search in Go. These approaches have generalized successfully to additional games. While computers have surpassed human expertise in a wide variety of games, open challenges remain and research focuses on identifying and developing new successful algorithmic foundations. WIREs Cogn Sci 2014, 5:193-205. doi: 10.1002/wcs.1278 CONFLICT OF INTEREST: The author has declared no conflicts of interest for this article. For further resources related to this article, please visit the WIREs website. PMID:26304308

  9. A Case Study: Analyzing City Vitality with Four Pillars of Activity-Live, Work, Shop, and Play.

    PubMed

    Griffin, Matt; Nordstrom, Blake W; Scholes, Jon; Joncas, Kate; Gordon, Patrick; Krivenko, Elliott; Haynes, Winston; Higdon, Roger; Stewart, Elizabeth; Kolker, Natali; Montague, Elizabeth; Kolker, Eugene

    2016-03-01

    This case study evaluates and tracks vitality of a city (Seattle), based on a data-driven approach, using strategic, robust, and sustainable metrics. This case study was collaboratively conducted by the Downtown Seattle Association (DSA) and CDO Analytics teams. The DSA is a nonprofit organization focused on making the city of Seattle and its Downtown a healthy and vibrant place to Live, Work, Shop, and Play. DSA primarily operates through public policy advocacy, community and business development, and marketing. In 2010, the organization turned to CDO Analytics ( cdoanalytics.org ) to develop a process that can guide and strategically focus DSA efforts and resources for maximal benefit to the city of Seattle and its Downtown. CDO Analytics was asked to develop clear, easily understood, and robust metrics for a baseline evaluation of the health of the city, as well as for ongoing monitoring and comparisons of the vitality, sustainability, and growth. The DSA and CDO Analytics teams strategized on how to effectively assess and track the vitality of Seattle and its Downtown. The two teams filtered a variety of data sources, and evaluated the veracity of multiple diverse metrics. This iterative process resulted in the development of a small number of strategic, simple, reliable, and sustainable metrics across four pillars of activity: Live, Work, Shop, and Play. Data during the 5 years before 2010 were used for the development of the metrics and model and its training, and data during the 5 years from 2010 and on were used for testing and validation. This work enabled DSA to routinely track these strategic metrics, use them to monitor the vitality of Downtown Seattle, prioritize improvements, and identify new value-added programs. As a result, the four-pillar approach became an integral part of the data-driven decision-making and execution of the Seattle community's improvement activities. The approach described in this case study is actionable, robust, inexpensive

  10. To What Extent Might Role Play Be a Useful Tool for Learning Mathematics?

    ERIC Educational Resources Information Center

    Williams, Helen

    2012-01-01

    To most children in primary school role-play is just something you do, and something you enjoy. It is part-and-parcel of being at school, part of the normal classroom activity. So, why can it not just be a normal part of learning mathematics? Can we study learners "in role", and make judgments about what they learn, and how they learn? This is the…

  11. The Learner's Permit.

    ERIC Educational Resources Information Center

    Mayhew, Daniel R.

    2003-01-01

    Considers the role and value of an extended learner's period in a graduated driver-licensing system through a review of the literature. Concludes that further research is needed on the safety benefits and optional features of the learner period. (Contains 1 figure, 3 tables, and 41 references.) (AUTHOR/WFA)

  12. Understanding Oral Learners

    ERIC Educational Resources Information Center

    Moon, W. Jay

    2012-01-01

    A five-year research project of seminary students from various cultural backgrounds revealed that the slight majority of contemporary seminary students studied are oral learners. Oral learners learn best and have their lives most transformed when professors utilize oral teaching and assessment methods. After explaining several preferences of oral…

  13. Adult Learners in Universities.

    ERIC Educational Resources Information Center

    Baker, Janette, Ed.

    1981-01-01

    Theories on adult development and learning and some of the Ontario universities' programs and services for the adult learner are examined, and Athabasca University, Alberta's answer to the British Open University, is described. Peter O'Donnell discusses adult learners' needs and explains how Athabasca University serves this specific type of…

  14. The Lifelong Learner.

    ERIC Educational Resources Information Center

    Gross, Ronald

    Designed to provide a general guide and stimuli for lifelong learning, this book examines all the positive factors of independent study. Lifelong learning is defined as self-directed growth free from the traditional schooling procedures. Chapters discuss the following: the lifelong learner; profiles of such learners in action; how to be…

  15. A Learner Centered Education.

    ERIC Educational Resources Information Center

    Ballard, Florence N.

    This paper proposes a learner-centered educational system, focusing on aspects that are intrinsically associated with the modern educational system, such as the curriculum, school community, parents, learners, and educational support personnel. It examines: primary level preparation (literacy, numeracy, and basic knowledge; examination and…

  16. Grading Exceptional Learners

    ERIC Educational Resources Information Center

    Jung, Lee Ann; Guskey, Thomas R.

    2010-01-01

    Teachers often grapple with the challenge of giving report card grades to students with learning disabilities and English language learners. The authors offer a five-step model that "offers a fair, accurate, and legal way to adapt the grading process for exceptional learners." The model begins with a high-quality reporting system for all students…

  17. Learner-Centered Education.

    ERIC Educational Resources Information Center

    O'Neil, Robert M.

    There is no clear consensus of the term "learner-centered reform." Learner-centered reform has become by implication either the cause or the consequence of inflated grades, lowered admission requirements, affirmative action, elimination of language and other requirements, student evaluation of teaching, abandonment of research, and many other ills…

  18. Metabolic Thresholds and Validated Accelerometer Cutoff Points for the Actigraph GT1M in Young Children Based on Measurements of Locomotion and Play Activities

    ERIC Educational Resources Information Center

    Jimmy, Gerda; Dossegger, Alain; Seiler, Roland; Mader, Urs

    2012-01-01

    The purpose of the current study was to determine metabolic thresholds and subsequent activity intensity cutoff points for the ActiGraph GT1M with various epochs spanning from 5 to 60 sec in young children. Twenty-two children, aged 4 to 9 years, performed 10 different activities including locomotion and play activities. Energy expenditure was…

  19. Differences in cortical activity related to motor planning between experienced guitarists and non-musicians during guitar playing.

    PubMed

    Wright, David J; Holmes, Paul S; Di Russo, Francesco; Loporto, Michela; Smith, Dave

    2012-06-01

    The influence of motor skill learning on movement-related brain activity was investigated using electroencephalography. Previous research has indicated that experienced performers display movement-related cortical potentials (MRCPs) of smaller amplitude and later onset compared to novices. Unfortunately, previous studies have lacked ecological validity with experimenters recording the MRCP prior to simple motor tasks and applying the results to more complex motor skills. This study replicated previous research using an ecologically valid motor skill; recording the MRCP from a group of experienced guitarists and a control group of non-musicians while they played a simple scale on the guitar. Results indicated no difference between groups in early motor planning. In contrast, the later, negative slope and motor potential components were of smaller amplitude and the negative slope began later in the experienced guitarists. The data may indicate that, for experienced guitarists, a reduced level of effort is required during the motor preparation phase of the task. These findings have implications for musical instrument learning as well as motor skill acquisition in general. PMID:21899906

  20. The child play behavior and activity questionnaire: a parent-report measure of childhood gender-related behavior in China.

    PubMed

    Yu, Lu; Winter, Sam; Xie, Dong

    2010-06-01

    Boys and girls establish relatively stable gender stereotyped behavior patterns by middle childhood. Parent-report questionnaires measuring children's gender-related behavior enable researchers to conduct large-scale screenings of community samples of children. For school-aged children, two parent-report instruments, the Child Game Participation Questionnaire (CGPQ) and the Child Behavior and Attitude Questionnaire (CBAQ), have long been used for measuring children's sex-dimorphic behaviors in Western societies, but few studies have been conducted using these measures for Chinese populations. The current study aimed to empirically examine and modify the two instruments for their applications to Chinese society. Parents of 486 Chinese boys and 417 Chinese girls (6-12 years old) completed a questionnaire comprising items from the CGPQ and CBAQ, and an additional 14 items specifically related to Chinese gender-specific games. Items revealing gender differences in a Chinese sample were identified and used to construct a Child Play Behavior and Activity Questionnaire (CPBAQ). Four new scales were generated through factor analysis: a Gender Scale, a Girl Typicality Scale, a Boy Typicality Scale, and a Cross-Gender Scale (CGS). These scales had satisfactory internal reliabilities and large effect sizes for gender. The CPBAQ is believed to be a promising instrument for measuring children's gender-related behavior in China. PMID:18719986

  1. The Child Play Behavior and Activity Questionnaire: A Parent-Report Measure of Childhood Gender-Related Behavior in China

    PubMed Central

    Winter, Sam; Xie, Dong

    2008-01-01

    Boys and girls establish relatively stable gender stereotyped behavior patterns by middle childhood. Parent-report questionnaires measuring children’s gender-related behavior enable researchers to conduct large-scale screenings of community samples of children. For school-aged children, two parent-report instruments, the Child Game Participation Questionnaire (CGPQ) and the Child Behavior and Attitude Questionnaire (CBAQ), have long been used for measuring children’s sex-dimorphic behaviors in Western societies, but few studies have been conducted using these measures for Chinese populations. The current study aimed to empirically examine and modify the two instruments for their applications to Chinese society. Parents of 486 Chinese boys and 417 Chinese girls (6–12 years old) completed a questionnaire comprising items from the CGPQ and CBAQ, and an additional 14 items specifically related to Chinese gender-specific games. Items revealing gender differences in a Chinese sample were identified and used to construct a Child Play Behavior and Activity Questionnaire (CPBAQ). Four new scales were generated through factor analysis: a Gender Scale, a Girl Typicality Scale, a Boy Typicality Scale, and a Cross-Gender Scale (CGS). These scales had satisfactory internal reliabilities and large effect sizes for gender. The CPBAQ is believed to be a promising instrument for measuring children’s gender-related behavior in China. PMID:18719986

  2. Learner-Centered Teaching Techniques in Astronomy 101

    NASA Astrophysics Data System (ADS)

    Jones, L. V.; Marschall, L. A.; Prather, E.

    2003-12-01

    We present preliminary results of studies done on learner-centered teaching techniques with students in Astronomy 101. Results for two classes taught at Gettysburg College this fall will be presented. One class used learner-centered activities, the other did not. A diagnostic survey was given to both classes before and after. Specific newly designed activities were tested as well.

  3. Platelet-Activating Factor Receptor Plays a Role in Lung Injury and Death Caused by Influenza A in Mice

    PubMed Central

    Garcia, Cristiana C.; Russo, Remo C.; Guabiraba, Rodrigo; Fagundes, Caio T.; Polidoro, Rafael B.; Tavares, Luciana P.; Salgado, Ana Paula C.; Cassali, Geovanni D.; Sousa, Lirlândia P.; Machado, Alexandre V.; Teixeira, Mauro M.

    2010-01-01

    Influenza A virus causes annual epidemics which affect millions of people worldwide. A recent Influenza pandemic brought new awareness over the health impact of the disease. It is thought that a severe inflammatory response against the virus contributes to disease severity and death. Therefore, modulating the effects of inflammatory mediators may represent a new therapy against Influenza infection. Platelet activating factor (PAF) receptor (PAFR) deficient mice were used to evaluate the role of the gene in a model of experimental infection with Influenza A/WSN/33 H1N1 or a reassortant Influenza A H3N1 subtype. The following parameters were evaluated: lethality, cell recruitment to the airways, lung pathology, viral titers and cytokine levels in lungs. The PAFR antagonist PCA4248 was also used after the onset of flu symptoms. Absence or antagonism of PAFR caused significant protection against flu-associated lethality and lung injury. Protection was correlated with decreased neutrophil recruitment, lung edema, vascular permeability and injury. There was no increase of viral load and greater recruitment of NK1.1+ cells. Antibody responses were similar in WT and PAFR-deficient mice and animals were protected from re-infection. Influenza infection induces the enzyme that synthesizes PAF, lyso-PAF acetyltransferase, an effect linked to activation of TLR7/8. Therefore, it is suggested that PAFR is a disease-associated gene and plays an important role in driving neutrophil influx and lung damage after infection of mice with two subtypes of Influenza A. Further studies should investigate whether targeting PAFR may be useful to reduce lung pathology associated with Influenza A virus infection in humans. PMID:21079759

  4. Learner-Content-Interface as an Approach for Self-Reliant and Student-Centered Learning

    ERIC Educational Resources Information Center

    Nicolay, Robin; Schwennigcke, Bastian; Sahl, Sarah; Martens, Alke

    2015-01-01

    Conceptualization and implementation of computer supported teaching and training is currently not tailored to the paradigm of learner centration. Many technical solutions lack transparency and consistency regarding the supported learner activities. An insight into learners activities correlated to learning tasks is needed. In this paper we outline…

  5. Peroxisome proliferator-activated receptor alpha plays a crucial role in behavioral repetition and cognitive flexibility in mice

    PubMed Central

    D'Agostino, Giuseppe; Cristiano, Claudia; Lyons, David J.; Citraro, Rita; Russo, Emilio; Avagliano, Carmen; Russo, Roberto; Raso, Giuseppina Mattace; Meli, Rosaria; De Sarro, Giovambattista; Heisler, Lora K.; Calignano, Antonio

    2015-01-01

    Background/objectives Nuclear peroxisome proliferator activated receptor-α (PPAR-α) plays a fundamental role in the regulation of lipid homeostasis and is the target of medications used to treat dyslipidemia. However, little is known about the role of PPAR-α in mouse behavior. Methods To investigate the function of Ppar-α in cognitive functions, a behavioral phenotype analysis of mice with a targeted genetic disruption of Ppar-α was performed in combination with neuroanatomical, biochemical and pharmacological manipulations. The therapeutic exploitability of PPAR-α was probed in mice using a pharmacological model of psychosis and a genetic model (BTBR T + tf/J) exhibiting a high rate of repetitive behavior. Results An unexpected role for brain Ppar-α in the regulation of cognitive behavior in mice was revealed. Specifically, we observed that Ppar-α genetic perturbation promotes rewiring of cortical and hippocampal regions and a behavioral phenotype of cognitive inflexibility, perseveration and blunted responses to psychomimetic drugs. Furthermore, we demonstrate that the antipsychotic and autism spectrum disorder (ASD) medication risperidone ameliorates the behavioral profile of Ppar-α deficient mice. Importantly, we reveal that pharmacological PPAR-α agonist treatment in mice improves behavior in a pharmacological model of ketamine-induced behavioral dysinhibition and repetitive behavior in BTBR T + tf/J mice. Conclusion Our data indicate that Ppar-α is required for normal cognitive function and that pharmacological stimulation of PPAR-α improves cognitive function in pharmacological and genetic models of impaired cognitive function in mice. These results thereby reveal an unforeseen therapeutic application for a class of drugs currently in human use. PMID:26137440

  6. The Fear of Play

    ERIC Educational Resources Information Center

    Almon, Joan

    2009-01-01

    Real play--play that is initiated and directed by children and that bubbles up from within the child rather than being imposed by adults--has largely disappeared from the landscape of childhood in the United States. There are many reasons for this, such as the long hours spent in front of screens each day or in activities organized by adults. In…

  7. Return to Play

    ERIC Educational Resources Information Center

    Mangan, Marianne

    2013-01-01

    Call it physical activity, call it games, or call it play. Whatever its name, it's a place we all need to return to. In the physical education, recreation, and dance professions, we need to redesign programs to address the need for and want of play that is inherent in all of us.

  8. Play as Experience

    ERIC Educational Resources Information Center

    Henricks, Thomas S.

    2015-01-01

    The author investigates what he believes one of the more important aspects of play--the experience it generates in its participants. He considers the quality of this experience in relation to five ways of viewing play--as action, interaction, activity, disposition, and within a context. He treats broadly the different forms of affect, including…

  9. Playing with Autistic Children.

    ERIC Educational Resources Information Center

    Casner, Mary W.; Marks, Susan F.

    The paper looks at the development of a play group for autistic children with descriptions of the autistic population, the daily program, the program's philosophy, the play group model, and actual lessons. Children, who ranged in age from 5 to 9 years, often chose activities which were self-stimulating and/or repetitive. The daily program included…

  10. Designing Substantive Playing Tests- A Model.

    ERIC Educational Resources Information Center

    Byo, James L.

    2001-01-01

    Discusses the use of playing tests in music education, stating that the tests can be useful beyond assessment measurement. Describes how to create performance tests based upon the idea of an accomplished learner. Addresses how to give the tests and presents implications gleaned from field test results. (CMK)

  11. Member of the CREB/ATF protein family, but not CREB alpha plays an active role in BLV tax trans activation in vivo.

    PubMed Central

    Kiss-Toth, E; Paca-uccaralertkun, S; Unk, I; Boros, I

    1993-01-01

    The trans activator protein of Bovine Leukaemia Virus (tax) increases the rate of transcription from the virus promoter through 21 bp sequences located in three tandem copies in the virus LTR. Based on data obtained by three different experimental approaches we concluded that the central CRE-like motif found in each of the BLV 21 bp repeats plays an important and indispensable role in tax mediated trans activation. These include (i) in vivo analysis of the function of mutant 21 bp sequences in transient transfection, (ii) gel mobility shift assay to show that CREB binds to BLV 21 bp repeats in vitro and (iii) the demonstration that the production of antisense CREB mRNA inhibits tax trans activation. Further studies with different deletion mutant CREB proteins suggest that although CREB alpha can interact with factors involved in BLV trans activation, it does not promote transcription initiation; consequently some other member/s of the CREB/ATF family must be involved. Images PMID:8396235

  12. Play Spaces in Denmark.

    ERIC Educational Resources Information Center

    Mitchell, Edna; Anderson, Robert T.

    1980-01-01

    Describes the variety of play spaces found in urban areas in Denmark: in banks, stores and individual businesses, neighborhood parks and small pocket playgrounds, specialized adventure and traffic playgrounds with supervised activities, and commercial amusement parks. (CM)

  13. Differences in Perceived Competence and Physical Activity Levels during Single-Gender Modified Basketball Game Play in Middle School Physical Education

    ERIC Educational Resources Information Center

    Slingerland, Menno; Haerens, Leen; Cardon, Greet; Borghouts, Lars

    2014-01-01

    Creating environments in physical education (PE) that foster perceived competence and physical activity during gender-mixed game play lessons is a challenge, especially with adolescent girls. This study is a small experiment in one PE lesson that aimed to increase the perceived competence and in-class physical activity in girls, by applying a…

  14. An Impact and Feasibility Evaluation of a Six-Week (Nine Hour) Active Play Intervention on Fathers' Engagement with Their Preschool Children: A Feasibility Study

    ERIC Educational Resources Information Center

    Houghton, Laura J.; O'Dwyer, Mareesa; Foweather, Lawrence; Watson, Paula; Alford, Simon; Knowles, Zoe R.

    2015-01-01

    Research has demonstrated the benefits of father involvement with their children and a link between uninvolved fatherhood and societal problems. Children's Centres (n?=?15) received 6?×?90-minute active play sessions designed to foster 6 aspects of parental engagement. Fathers' engagement and attitudes to child physical activity were…

  15. Profiling the Phonological Processes Shaping the Fossilized IL of Adult Learners of English as a Foreign Language: Some Theoretical Implications.

    ERIC Educational Resources Information Center

    Monroy, Rafael

    2001-01-01

    Describes the frozen interlanguage (IL) of adult learners of English in a natural setting to profile phonological processes that underlie their output. Also examines the impact on learners' oral behavior and the role played by transfer and developmental processes in such behavior. Analysis yields 10 processes shaping learners' IL that are…

  16. Evaluating the effects of the Lunchtime Enjoyment Activity and Play (LEAP) school playground intervention on children’s quality of life, enjoyment and participation in physical activity

    PubMed Central

    2014-01-01

    Background An emerging public health strategy is to enhance children’s opportunities to be physically active during school break periods. The aim of this study was to evaluate the effects of the Lunchtime Enjoyment Activity and Play (LEAP) school playground intervention on primary school children’s quality of life (QOL), enjoyment and participation in physical activity (PA). Methods This study consisted of a movable/recycled materials intervention that included baseline, a 7-week post-test and an 8-month follow-up data collection phase. Children within an intervention school (n = 123) and a matched control school (n = 152) aged 5-to-12-years-old were recruited for the study. Children’s PA was measured using a combination of pedometers and direct observation (SOPLAY). Quality of life, enjoyment of PA and enjoyment of lunchtime activities were assessed in the 8-12 year children. A multi-level mixed effect linear regression model was applied in STATA (version 12.0) using the xtmixed command to fit linear mixed models to each of the variables to examine whether there was a significant difference (p < 0.05) between the intervention and control school at the three time points (pre, post and follow-up). Results Significant overall interaction effects (group × time) were identified for children’s mean steps and distance (pedometers) in the intervention school compared to the control school. Intervention school children also spent significantly higher proportions within specified target areas engaged in higher PA intensities in comparison to the control school at both the 7-week post-test and 8-month follow-up. A short-term treatment effect was revealed after 7-weeks for children’s physical health scale QOL, enjoyment of PA and enjoyment of intra-personal play activities. Conclusions Examining the effects of this school playground intervention over a school year suggested that the introduction of movable/recycled materials can have a significant

  17. Morality Play

    ERIC Educational Resources Information Center

    Reutter, Vicki

    2006-01-01

    In a perfect world, students would apply the ethics taught to them in guiding their school-related use of technology to their activities beyond campus. However in reality, they often do not make the connection. Educators should be aware of how students are using entertainment technologies and help them make good decisions--both on and off their…

  18. Factors associated with perception of risk of contracting HIV among secondary school female learners in Mbonge subdivision of rural Cameroon

    PubMed Central

    Tarkang, Elvis Enowbeyang

    2014-01-01

    Introduction Since learners in secondary schools fall within the age group hardest hit by HIV/AIDS, it is obvious that these learners might be at high risk of contracting HIV/AIDS. However, little has been explored on the perception of risk of contracting HIV among secondary school learners in Cameroon. This study aimed at examining the perception of risk of contracting HIV among secondary school learners in Mbonge subdivision of rural Cameroon using the Health Belief Model (HBM) as framework. Methods A quantitative, correlational design was adopted, using a self-administered questionnaire to collect data from 210 female learners selected through disproportional, stratified, simple random sampling technique, from three participating senior secondary schools. Statistics were calculated using SPSS version 20 software program. Results Only 39.4% of the respondents perceived themselves to be at high risk of contracting HIV, though the majority, 54.0% were sexually active. Multinomial logistic regression analyses show that sexual risk behaviours (p=0.000) and the Integrated Value Mapping (IVM) of the perception components of the HBM are the most significant factors associated with perception of risk of contracting HIV at the level p<0.05. Conclusion The findings of this study can play an instrumental role in the development of effective preventive and interventional messages for adolescents in Cameroon. PMID:25309659

  19. Schoolyard Inquiry for English Language Learners

    ERIC Educational Resources Information Center

    Westervelt, Miriam

    2007-01-01

    This article presents outdoor inquiry activities to help English Language Learner (ELL) students learn life science concepts. As a public high school ELL science teacher, the author of this article use these place-based and scaffolded inquiry activities outside to reinforce concepts she teaches in the classroom all year long. Through inductive…

  20. Practices and Prospects of Learner Autonomy: Teachers' Perceptions

    ERIC Educational Resources Information Center

    Al Asmari, AbdulRahman

    2013-01-01

    Language learning process works through the learners' own reflection on how they learn and it makes learners active in the sense that they learn to analyze their learning strategies. So they start making decisions, e.g., whether to improve them or not, and in which way. Generally, this trait is missing in traditional language teaching process and…

  1. Factors Driving Learner Success in Online Professional Development

    ERIC Educational Resources Information Center

    Vu, Phu; Cao, Vien; Vu, Lan; Cepero, Jude

    2014-01-01

    This study examined factors that contributed to the success of online learners in an online professional development course. Research instruments included an online survey and learners' activity logs in an online professional development course for 512 in-service teachers. The findings showed that there were several factors affecting online…

  2. Building a Dynamic Online Learning Community among Adult Learners.

    ERIC Educational Resources Information Center

    Wang, Minjuan; Sierra, Christina; Folger, Terre

    2003-01-01

    Examines the nature of learning communities constructed among a diverse group of adult learners in an international online graduate-level course. Discusses independent work, team tasks, the variety of computer-mediated communication tools used, and implications for promoting adult learners' active participation in online learning and instructional…

  3. Assessing the Literacy Needs of Adult Learners of ESL. ERIC Digest.

    ERIC Educational Resources Information Center

    Santopietro, Kathleen; Peyton, Joy Kreeft

    Traditionally, student assessment has focused on measuring learner skills. Assessment of literacy needs, from the learner's perspective, is also an important part of an instructional program. This digest focuses on ways to determine what learners want or believe they need to learn. Many of the activities described can include or lead to assessment…

  4. Comparing Learner Community Behavior in Multiple Presentations of a Massive Open Online Course

    ERIC Educational Resources Information Center

    Gallagher, Silvia Elena; Savage, Timothy

    2015-01-01

    Massive Online Open Courses (MOOCs) can create large scale communities of learners who collaborate, interact and discuss learning materials and activities. MOOCs are often delivered multiple times with similar content to different cohorts of learners. However, research into the differences of learner communication, behavior and expectation between…

  5. Learner Autonomy as a Predictor of Course Success and Final Grades in Community College Online Courses

    ERIC Educational Resources Information Center

    Yen, Cherng-Jyh; Liu, Simon

    2009-01-01

    This study employed a quantitative research design to examine the predictive relationships between: (a) learner autonomy and course success; and (b) learner autonomy and final grades in community college online courses. Learner autonomy was defined as the characteristic of an individual who exhibited intentional behavior in learning activities.…

  6. Exploring South African Grade 11 Learners' Perceptions of Classroom Inquiry: Validation of a Research Instrument

    ERIC Educational Resources Information Center

    Dudu, Washington T.; Vhurumuku, Elaosi

    2012-01-01

    This paper discusses the adoption and validation of a research instrument, on determining learners' levels of perception of classroom inquiry based on data collected from South African Grade 11 learners. The Learners' Perception of Classroom Inquiry (LPCI) instrument consists only of Likert-type items which rank activities according to how often…

  7. The Effect of Reading on Second-Language Learners' Production in Tasks

    ERIC Educational Resources Information Center

    Collentine, Karina

    2016-01-01

    Tasks provide engaging ways to involve learners in meaningful, real-world activities with the foreign language (FL). Yet selecting classroom tasks suitable to learners' linguistic readiness is challenging, and task-based research is exploring the relationship between learners' overall abilities (e.g., reading, grammatical) and the complexity and…

  8. Imagination, Playfulness, and Creativity in Children's Play with Different Toys

    ERIC Educational Resources Information Center

    Mo????ller, Signe?? Juhl?

    2015-01-01

    Based on a four-month experimental study of preschool children's play with creative-construction and social-fantasy toys, the author examines the in?uence of both types of toys on the play of preschool children. Her comparative analysis considers the impact of transformative play on the development of imagination during play activities and…

  9. "Play to Learn": A Case-Study of Parent/Carer and Child Engagement with a Physical Activity Website Resource

    ERIC Educational Resources Information Center

    Hughes, Helen; Fleming, Scott

    2015-01-01

    In 2007, Sport Wales produced guidance for practitioners delivering the new Foundation Phase curriculum for children aged three to seven years. A focus was on physical development and in 2009 a resource entitled "Play to Learn" was developed supported by a website launched in 2011. The present study addresses (non-)engagement with the…

  10. Fair Play Game: A Group Contingency Strategy to Increase Students' Active Behaviours in Physical Education

    ERIC Educational Resources Information Center

    Vidoni, Carla; Lee, Chang-Hung; Azevedo, L. B.

    2014-01-01

    A dependent group contingency strategy called Fair Play Game was applied to promote increase in number of steps during physical education classes for sixth-grade students. Results from a multiple baseline design across three classes showed that the mean number of steps for baseline vs. intervention were: Class 1: 43 vs. 64 steps/minute; Class 2:…

  11. What's Eating into School Recess? Implications of Extended Eating for Free Play and Physical Activity

    ERIC Educational Resources Information Center

    Wyver, Shirley; Engelen, Lina; Bundy, Anita; Naughton, Geraldine

    2012-01-01

    An assumption made when designing recess interventions in schools is that there is a clear demarcation between eating time and play time. We used observational data conducted as part of the Sydney Playground Project to test if this assumption was correct. The Sydney Playground Project is a cluster randomised controlled trial of a recess…

  12. You Can Be in a Group and Still Not Cooperate. Collaborative Approaches and Cooperative Learning Activities for Adult Learners.

    ERIC Educational Resources Information Center

    Parma City School District, OH.

    This handbook defines and describes the benefits of both collaborative approaches and cooperative techniques. An introduction uses watercolor marbling as a metaphor for collaborative approaches and cooperative activities. Section I provides research results regarding problems of adult literacy programs, skills employers want, and Bloom's taxonomy.…

  13. Exploring Shifts in Middle School Learners' Modeling Activity While Generating Drawings, Animations, and Computational Simulations of Molecular Diffusion

    ERIC Educational Resources Information Center

    Wilkerson-Jerde, Michelle H.; Gravel, Brian E.; Macrander, Christopher A.

    2015-01-01

    Modeling and using technology are two practices of particular interest to K-12 science educators. These practices are inextricably linked among professionals, who engage in modeling activity with and across a variety of representational technologies. In this paper, we explore the practices of five sixth-grade girls as they generated models of…

  14. Design Issues Related to the Evaluation of Learner--Computer Interaction in a Web-Based Environment: Activities v. Tasks

    ERIC Educational Resources Information Center

    Hemard, Dominique

    2006-01-01

    If web-based technology is increasingly becoming the central plank of contemporary teaching and learning processes, there is still too little evidence to suggest that it is delivering purposeful learning activities beyond its widely perceived potential as a learning resource providing content and learning objects. This is due in part to the…

  15. Learner Characteristics, Learning Environments and Constructivist Epistemologies.

    ERIC Educational Resources Information Center

    Simpson, Gary

    2001-01-01

    Focuses on a current research project that examines the measurement of learner characteristics (multiple intelligence, learning style, learner ability), learner perceptions of the classroom (constructivist learning environment survey and views about teaching and learning), and learner constructs. (Author/MM)

  16. The effect of family therapy on the changes in the severity of on-line game play and brain activity in adolescents with on-line game addiction

    PubMed Central

    Han, Doug Hyun; Kim, Sun Mi; Lee, Young Sik; Renshaw, Perry F.

    2015-01-01

    We evaluated whether a brief 3-week family therapy intervention would change patterns of brain activation in response to affection and gaming cues in adolescents from dysfunctional families who met criteria for on-line game addiction. Fifteen adolescents with on-line game addiction and fifteen adolescents without problematic on-line game play and an intact family structure were recruited. Over 3 weeks, families were asked to carry out homework assignments focused on increasing family cohesion for more than 1 hour/day and 4 days/week. Before therapy, adolescents with on-line game addiction demonstrated decreased activity as measured by functional magnetic resonance imaging (fMRI) within the caudate, middle temporal gyrus, and occipital lobe in response to images depicting parental affection and increased activity of the middle frontal and inferior parietal in response scenes from on-line games, relative to healthy comparison subjects. Improvement in perceived family cohesion following 3 weeks of treatment was associated with an increase in the activity of the caudate nucleus in response to affection stimuli and was inversely correlated with changes in on-line game playing time. With evidence of brain activation changes in response to on-line game playing cues and images depicting parental love, the present findings suggest that family cohesion may be an important factor in the treatment of problematic on-line game playing. PMID:22698763

  17. Promoting healthy eating, active play and sustainability consciousness in early childhood curricula, addressing the Ben10™ problem: a randomised control trial

    PubMed Central

    2014-01-01

    Background This paper details the research protocol for a study funded by the Australian Research Council. An integrated approach towards helping young children respond to the significant pressures of ‘360 degree marketing’ on their food choices, levels of active play, and sustainability consciousness via the early childhood curriculum is lacking. The overall goal of this study is to evaluate the efficacy of curriculum interventions that educators design when using a pedagogical communication strategy on children’s knowledge about healthy eating, active play and the sustainability consequences of their toy food and toy selections. Methods/Design This cluster-randomised trial will be conducted with 300, 4 to 5 year-old children attending pre-school. Early childhood educators will develop a curriculum intervention using a pedagogical communication strategy that integrates content knowledge about healthy eating, active play and sustainability consciousness and deliver this to their pre-school class. Children will be interviewed about their knowledge of healthy eating, active play and the sustainability consequences of their food and toy selections. Parents will complete an Eating and Physical Activity Questionnaire rating their children’s food preferences, digital media viewing and physical activity habits. All measures will be administered at baseline, the end of the intervention and 6 months post intervention. Informed consent will be obtained from all parents and the pre-school classes will be allocated randomly to the intervention or wait-list control group. Discussion This study is the first to utilise an integrated pedagogical communication strategy developed specifically for early childhood educators focusing on children’s healthy eating, active play, and sustainability consciousness. The significance of the early childhood period, for young children’s learning about healthy eating, active play and sustainability, is now unquestioned. The specific

  18. Developing an Active Play Resource for a Range of Australian Early Childhood Settings: Formative Findings and Recommendations

    ERIC Educational Resources Information Center

    Riethmuller, Annaleise; McKeen, Kim; Okely, Anthony D.; Bell, Colin; de Silva Sanigorski, Andrea

    2009-01-01

    Physical activity habits are established in early childhood. Increasing a child's fundamental movement skill confidence and competence may result in a trajectory of increased physical activity and a lower risk of becoming overweight. The evidence upon which the promotion of physical activity in early childhood settings is based is tenuous. This…

  19. The "Power Play! Campaign's School Idea & Resource Kits" Improve Determinants of Fruit and Vegetable Intake and Physical Activity among Fourth- and Fifth-Grade Children

    ERIC Educational Resources Information Center

    Keihner, Angie Jo; Meigs, Reba; Sugerman, Sharon; Backman, Desiree; Garbolino, Tanya; Mitchell, Patrick

    2011-01-01

    Objective: Examine the effect of the "California Children's Power Play! Campaign's School Idea & Resource Kits" for fourth/fifth grades on the psychosocial determinants of fruit and vegetable (FV) intake and physical activity (PA). Methods: Randomized, controlled trial (n = 31 low-resource public schools; 1,154 children). Ten grade-specific,…

  20. The Curriculum Experiences of Pre-School Children in Northern Ireland: Classroom Practices in Terms of Child-Initiated Play and Adult-Directed Activities.

    ERIC Educational Resources Information Center

    Guimaraes, Sofia; McSherry, Kathleen

    2002-01-01

    Examined whether activities in the preschool curriculum across Northern Ireland are more adult-directed or child-directed. Findings from observations of 71 preschool settings showed that the curriculum of most reception settings was more adult-directed, while most nursery schools, play groups, and private day nurseries adopted a child-initiated…

  1. A Novel Method for Learner Assessment Based on Learner Annotations

    ERIC Educational Resources Information Center

    Noorbehbahani, Fakhroddin; Samani, Elaheh Biglar Beigi; Jazi, Hossein Hadian

    2013-01-01

    Assessment is one of the most essential parts of any instructive learning process which aims to evaluate a learner's knowledge about learning concepts. In this work, a new method for learner assessment based on learner annotations is presented. The proposed method exploits the M-BLEU algorithm to find the most similar reference annotations…

  2. Picture me playing-a portrait of participation and enjoyment of leisure activities in adolescents with cerebral palsy.

    PubMed

    Shikako-Thomas, Keiko; Shevell, Michael; Lach, Lucyna; Law, Mary; Schmitz, Norbert; Poulin, Chantal; Majnemer, Annette

    2013-03-01

    In recent years attention has been paid to the participation levels of children and youth with Cerebral Palsy (CP), particularly the extent to which they have the opportunity to be involved in and enjoy leisure activities. The objective of this study is to describe the level of participation and enjoyment in leisure activities among adolescents with CP and to identify potential differences in participation patterns related to sociodemographic attributes. A cross-sectional design was used. Participants were 175 adolescents 12-20 years old (M=15.3; ±2.2), GMFCS I=55/II=43/III=13/IV=18/V=39 who completed the Children's Assessment of Participation and Enjoyment (CAPE). The types of activities participants engaged in most frequently were social and recreational activities, whereas self-improvement and skill-based activities were least frequent. Social activities were the activities they enjoyed most. In general, participation decreases, as youth grow older. Girls engaged in more self-improvement activities than boys. Adolescents who study in special segregated schools experienced a lower diversity and intensity of engagement in all leisure activity domains. Adolescents who were not ambulatory and those presenting with more severe manual ability limitations participated less in all activity types except skill-based activities. Adolescents with CP place a high value on the ability to engage in activities of their own choosing and on interacting with friends. Engagement in a variety of leisure activities is important for a healthy development. Understanding the leisure patterns and preferences of this population, in addition to the contextual factors, may help in the elaboration of interventions and programs to promote a healthy development for this population. PMID:23291518

  3. A Repeated Measures Experiment of School Playing Environment to Increase Physical Activity and Enhance Self-Esteem in UK School Children

    PubMed Central

    Wood, Carly; Gladwell, Valerie; Barton, Jo

    2014-01-01

    School playtime provides daily opportunities for children to be active outdoors, but only makes small contributions to physical activity (PA) requirements. Natural environments facilitate unstructured PA and children report a preference for play in nature. Thus, play on the school field might encourage children to be more active during playtime. The primary aim of this study was to examine the impact of the school playing environment on children's PA. Descriptive data and fitness were assessed in 25 children aged 8–9 years from a single primary school. Over two consecutive weeks participants were allocated to either play on the school field or playground during playtime. The order of play in the two areas was randomised and counterbalanced. Moderate to vigorous PA (MVPA) was assessed during playtime on the last two days of each week using accelerometers. There was a significant interaction of environment and sex on MVPA during morning play (F(1,22) = 6.27; P<0.05; np2 = 0.222), but not during lunch (P>0.05; np2 = 0.060) or all of playtime combined (P>0.05; np2 = 0.140). During morning play boys were significantly more active than girls on the playground (t(23) = 1.32; P<0.01; n2 = 0.291), but not on the field (P>0.05; n2 = 0.071). For lunch (F(1,22) = 24,11; P<0.001; np2 = 0.523) and all of playtime combined (F(1,22) = 33.67; P<0.001; np2 = 0.616) there was a significant effect of environment. There was also a significant main effect of sex during lunch (F(1,22) = 11.56; P<0.01; np2 = 0.344) and all of playtime combined (F(1,22) = 12.37; P<0.01; np2 = 0.371). MVPA was higher on the field and boys were more active than girls. Play on the field leads to increases in MVPA, particularly in girls. The promising trend for the effect of the natural environment on MVPA indicates that interventions aimed at increasing MVPA should use the natural environment and that schools should encourage greater use of their

  4. The relation between children’s constructive play activities, spatial ability, and mathematical word problem-solving performance: a mediation analysis in sixth-grade students

    PubMed Central

    Oostermeijer, Meike; Boonen, Anton J. H.; Jolles, Jelle

    2014-01-01

    The scientific literature shows that constructive play activities are positively related to children’s spatial ability. Likewise, a close positive relation is found between spatial ability and mathematical word problem-solving performances. The relation between children’s constructive play and their performance on mathematical word problems is, however, not reported yet. The aim of the present study was to investigate whether spatial ability acted as a mediator in the relation between constructive play and mathematical word problem-solving performance in 128 sixth-grade elementary school children. This mediating role of spatial ability was tested by utilizing the current mediation approaches suggested by Preacher and Hayes (2008). Results showed that 38.16% of the variance in mathematical word problem-solving performance is explained by children’s constructive play activities and spatial ability. More specifically, spatial ability acted as a partial mediator, explaining 31.58% of the relation between constructive play and mathematical word problem-solving performance. PMID:25101038

  5. The PP-motif in luminal loop 2 of ZnT transporters plays a pivotal role in TNAP activation.

    PubMed

    Fujimoto, Shigeyuki; Tsuji, Tokuji; Fujiwara, Takashi; Takeda, Taka-Aki; Merriman, Chengfeng; Fukunaka, Ayako; Nishito, Yukina; Fu, Dax; Hoch, Eitan; Sekler, Israel; Fukue, Kazuhisa; Miyamae, Yusaku; Masuda, Seiji; Nagao, Masaya; Kambe, Taiho

    2016-09-01

    Secretory and membrane-bound zinc-requiring enzymes are thought to be activated by binding zinc in the early secretory pathway. One such enzyme, tissue-non-specific alkaline phosphatase (TNAP), is activated through a two-step mechanism, via protein stabilization and subsequent enzyme activation through metalation, by ZnT5-ZnT6 heterodimers or ZnT7 homodimers. However, little is known about the molecular basis underlying the activation process. In the present study, we found that the di-proline motif (PP-motif) in luminal loop 2 of ZnT5 and ZnT7 is important for TNAP activation. TNAP activity was significantly reduced in cells lacking ZnT5-ZnT6 heterodimers and ZnT7 homodimers [triple knockout (TKO) cells]. The decreased TNAP activity was restored by expressing hZnT5 with hZnT6 or hZnT7, but significantly less so (almost 90% less) by expressing mutants thereof in which the PP-motif was mutated to alanine (PP-AA). In TKO cells, overexpressed hTNAP was not completely activated, and it was converted less efficiently into the holo form by expressing a PP-AA mutant of hZnT5 with hZnT6, whose defects were not restored by zinc supplementation. The zinc transport activity of hZnT7 was not significantly impaired by the PP-AA mutation, indicating that the PP-motif is involved in the TNAP maturation process, although it does not control zinc transport activity. The PP-motif is highly conserved in ZnT5 and ZnT7 orthologues, and its importance for TNAP activation is conserved in the Caenorhabditis elegans hZnT5 orthologue CDF5. These results provide novel molecular insights into the TNAP activation process in the early secretory pathway. PMID:27303047

  6. Morphological Family Size Effects in Young First and Second Language Learners: Evidence of Cross-Language Semantic Activation in Visual Word Recognition

    ERIC Educational Resources Information Center

    de Zeeuw, Marlies; Verhoeven, Ludo; Schreuder, Robert

    2012-01-01

    This study examined to what extent young second language (L2) learners showed morphological family size effects in L2 word recognition and whether the effects were grade-level related. Turkish-Dutch bilingual children (L2) and Dutch (first language, L1) children from second, fourth, and sixth grade performed a Dutch lexical decision task on words…

  7. Picture Me Playing--A Portrait of Participation and Enjoyment of Leisure Activities in Adolescents with Cerebral Palsy

    ERIC Educational Resources Information Center

    Shikako-Thomas, Keiko; Shevell, Michael; Lach, Lucyna; Law, Mary; Schmitz, Norbert; Poulin, Chantal; Majnemer, Annette

    2013-01-01

    In recent years attention has been paid to the participation levels of children and youth with Cerebral Palsy (CP), particularly the extent to which they have the opportunity to be involved in and enjoy leisure activities. The objective of this study is to describe the level of participation and enjoyment in leisure activities among adolescents…

  8. A place for play? The influence of the home physical environment on children’s physical activity and sedentary behaviour

    PubMed Central

    2013-01-01

    The home environment is an important influence on the sedentary behaviour and physical activity of children, who have limited independent mobility and spend much of their time at home. This article reviews the current evidence regarding the influence of the home physical environment on the sedentary behaviour and physical activity of children aged 8–14 years. A literature search of peer reviewed articles published between 2005 and 2011 resulted in 38 observational studies (21 with activity outcomes, 23 with sedentary outcomes) and 11 experimental studies included in the review. The most commonly investigated behavioural outcomes were television watching and moderate to vigorous physical activity. Media equipment in the home and to a lesser extent the bedroom were positively associated with children’s sedentary behaviour. Physical activity equipment and the house and yard were not associated with physical activity, although environmental measures were exclusively self-reported. On the other hand, physical activity equipment was inversely associated with sedentary behaviours in half of studies. Observational studies that investigated the influence of the physical and social environment within the home space, found that the social environment, particularly the role of parents, was important. Experimental studies that changed the home physical environment by introducing a television limiting device successfully decreased television viewing, whereas the influence of introducing an active video game on activity outcomes was inconsistent. Results highlight that the home environment is an important influence on children’s sedentary behaviour and physical activity, about which much is still unknown. While changing or controlling the home physical environment shows promise for reducing screen based sedentary behaviour, further interventions are needed to understand the broader impact of these changes. Future studies should prioritise investigating the influence of the

  9. A place for play? The influence of the home physical environment on children's physical activity and sedentary behaviour.

    PubMed

    Maitland, Clover; Stratton, Gareth; Foster, Sarah; Braham, Rebecca; Rosenberg, Michael

    2013-01-01

    The home environment is an important influence on the sedentary behaviour and physical activity of children, who have limited independent mobility and spend much of their time at home. This article reviews the current evidence regarding the influence of the home physical environment on the sedentary behaviour and physical activity of children aged 8-14 years. A literature search of peer reviewed articles published between 2005 and 2011 resulted in 38 observational studies (21 with activity outcomes, 23 with sedentary outcomes) and 11 experimental studies included in the review. The most commonly investigated behavioural outcomes were television watching and moderate to vigorous physical activity. Media equipment in the home and to a lesser extent the bedroom were positively associated with children's sedentary behaviour. Physical activity equipment and the house and yard were not associated with physical activity, although environmental measures were exclusively self-reported. On the other hand, physical activity equipment was inversely associated with sedentary behaviours in half of studies. Observational studies that investigated the influence of the physical and social environment within the home space, found that the social environment, particularly the role of parents, was important. Experimental studies that changed the home physical environment by introducing a television limiting device successfully decreased television viewing, whereas the influence of introducing an active video game on activity outcomes was inconsistent. Results highlight that the home environment is an important influence on children's sedentary behaviour and physical activity, about which much is still unknown. While changing or controlling the home physical environment shows promise for reducing screen based sedentary behaviour, further interventions are needed to understand the broader impact of these changes. Future studies should prioritise investigating the influence of the home

  10. Instructional Prescriptions for Learner Control.

    ERIC Educational Resources Information Center

    Chung, Jaesam; Reigeluth, Charles M.

    1992-01-01

    Discussion of learner control in instructional management describes six learner control methods: (1) content control; (2) sequence control; (3) pace control; (4) display or strategy control; (5) internal processing control; and (6) advisor strategies. Relevant literature, both theoretical and empirical, is reviewed, and learner control and…

  11. Motivating Literacy Learners in Today's World

    ERIC Educational Resources Information Center

    Fletcher, J., Ed.; Parkhill, F., Ed.; Gillon, G., Ed.

    2010-01-01

    "Motivating Literacy Learners in Today's World" provides insights into a broad spectrum of children's literacy learning. Motivation is the key theme and the authors show how this can be achieved through reading for pleasure; in writing activities at a number of levels; and through oral language development. Chapters include: (1) Motivating…

  12. Goals, the Learner, and the Language Arts.

    ERIC Educational Resources Information Center

    Ediger, Marlow

    Teachers, principals, and supervisors need to determine the kinds of learners being taught in the school/class setting. Are pupils good by nature, bad, or neutral? Concepts held pertaining to each pupil assist in determining objectives, learning activities, and evaluation techniques. The Puritans believed that individuals were born evil or sinful.…

  13. Learner Generated versus Instructor Induced Visual Imagery.

    ERIC Educational Resources Information Center

    Lenze, James S.

    The concepts of imagery, mathemagenic behaviors, and generative imagery are reviewed; and the learner's use of visual imagery is discussed. Several studies have supported the idea that imagery is an active mental process that gives birth to learning. The concept of mathemagenic control or manipulation is of interest to the instructional designer.…

  14. Effective Strategies for Engaging Adult Learners

    ERIC Educational Resources Information Center

    Karge, Belinda Dunnick; Phillips, Kathleen M.; Jessee, Tammy; McCabe, Marjorie

    2011-01-01

    Innovative methods in teaching should be used in every college classroom to enhance student engagement, support any teaching environment and encourage inquiry among learners. Adults learn best by participation in relevant experiences and utilization of practical information. When adult students are active in their learning they are able to develop…

  15. Workplace Learning in Malaysia: The Learner's Perspective

    ERIC Educational Resources Information Center

    Muhamad, Mazanah; Idris, Khairuddin

    2005-01-01

    This paper offers a scenario of workplace learning as practiced in Malaysia. Based on survey research, the article describes learner profiles, learning provision and pattern. The analysis shows that Malaysians participate in formal workplace learning as part of their employment activities. Workplace learning in Malaysia is contextual, promoted by…

  16. Supporting a Learner Community with Software Agents

    ERIC Educational Resources Information Center

    Taurisson, Neil; Tchounikine, Pierre

    2004-01-01

    This paper describes a multi-agent approach that aims at supporting learners involved in a collective activity. We consider pedagogical situations where students have to explicitly define the articulation of their collective work and then achieve the different tasks they have defined. Our objective is to support these students by taking some of…

  17. Does excessive play of violent first-person-shooter-video-games dampen brain activity in response to emotional stimuli?

    PubMed

    Montag, Christian; Weber, Bernd; Trautner, Peter; Newport, Beate; Markett, Sebastian; Walter, Nora T; Felten, Andrea; Reuter, Martin

    2012-01-01

    The present case-control study investigated the processing of emotional pictures in excessive first-person-shooter-video-players and control persons. All participants of the fMRI experiment were confronted with pictures from four categories including pleasant, unpleasant, neutral content and pictures from the first-person-shooter-video-game 'Counterstrike'. Compared to controls, gamers showed a significantly lower activation of the left lateral medial frontal lobe while processing negative emotions. Another interesting finding of the study represents the higher activation of frontal and temporal brain areas in gamers when processing screen-shots from the first-person-shooter-video-game 'Counterstrike'. Higher brain activity in the lateral prefrontal cortex could represent a protection mechanism against experiencing negative emotions by down-regulating limbic brain activity. Due to a frequent confrontation with violent scenes, the first-person-shooter-video-gamers might have habituated to the effects of unpleasant stimuli resulting in lower brain activation. Individual differences in brain activations of the contrast Counterstrike>neutral pictures potentially resemble the activation of action-scripts related to the video-game. PMID:21982747

  18. Where can they play? Outdoor spaces and physical activity among adolescents in U.S. urbanized areas

    PubMed Central

    Boone-Heinonen, Janne; Casanova, Kathleen; Richardson, Andrea S.; Gordon-Larsen, Penny

    2010-01-01

    Objective To estimate behavior-specific effects of several objectively-measured outdoor spaces on different types of moderate to vigorous physical activity (MVPA) in a large, diverse sample of U.S. adolescents. Methods Using data from Wave I (1994–95) of the National Longitudinal Study of Adolescent Health (U.S., n=10,359) and a linked geographic information system, we calculated percent greenspace coverage and distance to the nearest neighborhood and major parks. Using sex-stratified multivariable logistic regression, we modeled reported participation in wheel-based activities, active sports, exercise, and ≥5 MVPA bouts/week as a function of each outdoor space variable, controlling for individual- and neighborhood-level sociodemographics. Results Availability of major or neighborhood parks was associated with higher participation in active sports and, in females, wheel-based activity and reporting ≥5 MVPA bouts/week [OR (95% CI): up to 1.71 (1.29. 2.27)]. Greater greenspace coverage was associated with reporting ≥5 MVPA bouts/week in males and females [OR (95% CI): up to 1.62 (1.10, 2.39) for 10.1 to 20% versus ≤10% greenspace] and exercise participation in females [OR (95% CI): up to 1.73 (1.21, 2.49)]. Conclusions Provision of outdoor spaces may promote different types of physical activities, with potentially greater benefits in female adolescents, who have particularly low physical activity levels. PMID:20655948

  19. Doing Your Part To Help Your Child Become SMART (Successful, Motivated, Autonomous, Responsible, Thoughtful): Six Workshops on Parenting SMART Learners.

    ERIC Educational Resources Information Center

    Sattes, Beth; Walsh, Jackie; Hickman, Mickey

    A SMART Learner is a lifelong learner who can adapt to rapid change and who possesses characteristics associated with success in and out of school. These workshop materials to help parents help their children become SMART learners provide: information from current research and best practice; learning activities that will actively engage parents in…

  20. Fragile Identities: Exploring Learner Identity, Learner Autonomy and Motivation through Young Learners' Voices

    ERIC Educational Resources Information Center

    Lamb, Terry Eric

    2011-01-01

    Recent research in the fields of motivation and learner autonomy in language learning has begun to explore their relationships to the construct of identity. This article builds on this through the voices of a group of six learners of French or German in a secondary school in England, over a two-year period. These young learners initially reveal a…

  1. p38 MAPK Is Activated but Does Not Play a Key Role during Apoptosis Induction by Saturated Fatty Acid in Human Pancreatic β-Cells

    PubMed Central

    Šrámek, Jan; Němcová-Fürstová, Vlasta; Balušíková, Kamila; Daniel, Petr; Jelínek, Michael; James, Roger F.; Kovář, Jan

    2016-01-01

    Saturated stearic acid (SA) induces apoptosis in the human pancreatic β-cells NES2Y. However, the molecular mechanisms involved are unclear. We showed that apoptosis-inducing concentrations of SA activate the p38 MAPK signaling pathway in these cells. Therefore, we tested the role of p38 MAPK signaling pathway activation in apoptosis induction by SA in NES2Y cells. Crosstalk between p38 MAPK pathway activation and accompanying ERK pathway inhibition after SA application was also tested. The inhibition of p38 MAPK expression by siRNA silencing resulted in a decrease in MAPKAPK-2 activation after SA application, but it had no significant effect on cell viability or the level of phosphorylated ERK pathway members. The inhibition of p38 MAPK activity by the specific inhibitor SB202190 resulted in inhibition of MAPKAPK-2 activation and noticeable activation of ERK pathway members after SA treatment but in no significant effect on cell viability. p38 MAPK overexpression by plasmid transfection produced an increase in MAPKAPK-2 activation after SA exposure but no significant influence on cell viability or ERK pathway activation. The activation of p38 MAPK by the specific activator anisomycin resulted in significant activation of MAPKAPK-2. Concerning the effect on cell viability, application of the activator led to apoptosis induction similar to application of SA (PARP cleavage and caspase-7, -8, and -9 activation) and in inhibition of ERK pathway members. We demonstrated that apoptosis-inducing concentrations of SA activate the p38 MAPK signaling pathway and that this activation could be involved in apoptosis induction by SA in the human pancreatic β-cells NES2Y. However, this involvement does not seem to play a key role. Crosstalk between p38 MAPK pathway activation and ERK pathway inhibition in NES2Y cells seems likely. Thus, the ERK pathway inhibition by p38 MAPK activation does not also seem to be essential for SA-induced apoptosis. PMID:26861294

  2. Design of the iPlay study: systematic development of a physical activity injury prevention programme for primary school children.

    PubMed

    Collard, Dorine C M; Chinapaw, Mai J M; van Mechelen, Willem; Verhagen, Evert A L M

    2009-01-01

    Health benefits of physical activity in children are well known. However, a drawback is the risk of physical activity-related injuries. Children are at particular risk for these injuries, because of a high level of exposure. Because of the high prevalence of physical activity injuries and the negative short- and long-term consequences, prevention of these injuries in children is important. This article describes how we systematically developed a school-based physical activity injury prevention programme using the intervention mapping (IM) protocol. IM describes a process for developing theory- and evidence-based health promotion programmes. The development can be described in six steps: (i) perform a needs assessment; (ii) identify programme and performance objectives; (iii) select methods and strategies; (iv) develop programme; (v) adopt and implement; and (vi) evaluate. First, the results of the needs assessment showed the injury problem in children and the different risk factors for physical activity injuries. Based on the results of the needs assessment the main focus of the injury prevention programme was described. Second, the overall programme objective of the injury prevention programme was defined as reducing the incidence of lower extremity physical activity injuries. Third, theoretical methods and practical strategies were selected to accomplish a decrease in injury incidence. The theoretical methods used were active learning, providing cues and scenario-based risk information, and active processing of information. The practical strategy of the injury prevention programme was an 8-month course about injury prevention to be used in physical education classes in primary schools. Fourth, programme materials that were used in the injury prevention programme were developed, including newsletters for children and parents, posters, exercises to improve motor fitness, and an information website. Fifth, an implementation plan was designed in order to ensure that

  3. The Older Language Learner.

    ERIC Educational Resources Information Center

    Schleppegrell, Mary

    Research on adult learning shows that there is no decline in ability to learn as people get older, that except for minor considerations such as hearing and vision loss, the age of the adult learner is not a major factor in language acquisition, and that the context in which adults learn is the major influence on their ability to acquire a new…

  4. Supporting Learners in Training.

    ERIC Educational Resources Information Center

    Montague, Ann; Hopkins, Linda

    A project was conducted in Australia to investigate the most effective ways whereby learners receive informal and formal support to assist them to successfully complete vocational education and training (VET), either in school or in business job-training programs. Data were collected through a literature review, a case study of 11 organizations,…

  5. Serving the Online Learner

    ERIC Educational Resources Information Center

    Boettcher, Judith V.

    2007-01-01

    Systems and services for recruiting, advising, and support of online students have seldom been at the top of the list when planning online and distance learning programs. That is now changing: Forces pushing advising and support services into the foreground include recognition of the student learner as "customer" and the increasing expectations…

  6. School Learners & Libraries.

    ERIC Educational Resources Information Center

    Karlsson, Jenni, Ed.

    This document presents papers from a conference held in November 1995 in Durban, KwaZulu-Natal, convened by the Education Policy Unit (EPU) of the University of Natal as part of research concerning the provision of library-based resources for school learners. Following an introduction are two chapters: "Identifying the Inherited Problems in the…

  7. Helping Young Hispanic Learners

    ERIC Educational Resources Information Center

    Garcia, Eugene E.; Jensen, Bryant

    2007-01-01

    Hispanics are the largest and youngest ethnic group in the United States. Moreover, young Hispanic children make up approximately 80 percent of the U.S. English language learner population. They are a heterogeneous group, born both inside and outside the United States and having origins in Mexico, Cuba, Central America, South America, and the…

  8. Empowering Leaders & Learners

    ERIC Educational Resources Information Center

    Umphrey, Jan

    2013-01-01

    Trevor Greene, the 2013 MetLife/NASSP National High School Principal of the Year, empowers staff members and students to be the best teachers and learners they can be and provides the community resources to support them. In this article, Greene, principal of Toppenish High School in Washington, shares his biggest motivator as a school leader and…

  9. Novice Learners in Cyberspace

    ERIC Educational Resources Information Center

    Youn, Soonkyoung

    2004-01-01

    Since the Internet was introduced in the field of Educational Technology, it has predominantly been seen as an instructional tool. A number of educational technologists point out that the Internet can be a powerful instructional tool that encourages learners to be involved in problem-solving by using a great deal of information and to enlarge and…

  10. Learner Autonomy Revisited

    ERIC Educational Resources Information Center

    Illes, Eva

    2012-01-01

    This article explores whether the perception of learner autonomy that is promoted in language pedagogy is suitable for preparing students to perform successfully in the changed circumstances of the use of English. Recent developments, which include the growing role of English as a lingua franca and computer-mediated communication (CMC), give rise…

  11. Libraries and Adult Learners.

    ERIC Educational Resources Information Center

    Josey, E. J., Ed.

    1982-01-01

    Of the 13 essays presented in this special issue on libraries and adult education, 8 focus on programs and services from the public library for adult learners. These essays provide information on: (1) an Education Information Centers Program (EIC) designed to complement employment skills training provided under the Comprehensive Employment and…

  12. Connecting with Latino Learners

    ERIC Educational Resources Information Center

    Rubinstein-Avila, Eliane

    2006-01-01

    The English-only initiatives sweeping the United States are mainstreaming English language learners into content-area classes designed for native or fluent English speakers, with little, if any, English as a second language (ESL) support. This spells trouble for the ever-growing population of Latinos because ESL teachers are not likely to have the…

  13. Gender and Learner Characteristics

    ERIC Educational Resources Information Center

    Hindal, Huda; Reid, Norman; Whitehead, Rex

    2013-01-01

    It is well established that girls and boys perform differently in traditional examinations in most countries. This study looks at a sample of 754 school students in Kuwait (aged about 13) and explores how boys and girls differ in the performance in a range of tests related to learner characteristics. The fundamental question is how boys and girls…

  14. of Iranian EFL Learners

    ERIC Educational Resources Information Center

    Rashidi, Nasser; Mortazavi, Fariba

    2012-01-01

    This research investigated the relationship between vocabulary learning strategies and vocabulary size of Iranian university EFL students. Participants in the present study were a total of 67 EFL learners, studying at Shiraz Azad University as senior English Translation students. The instruments utilized for data collection were three tests: A…

  15. Teachers as Learners

    ERIC Educational Resources Information Center

    Feiman-Nemser, Sharon

    2012-01-01

    In "Teachers as Learners", a collection of landmark essays, noted teacher educator and scholar Sharon Feiman-Nemser shines a light on teacher learning. Arguing that serious and sustained teacher learning is a necessary condition for ambitious student learning, she examines closely how teachers acquire, generate, and use knowledge about teaching…

  16. California's English Learner Students

    ERIC Educational Resources Information Center

    Hill, Laura E.

    2012-01-01

    English Learner (EL) students in California's schools are numerous and diverse, and they lag behind their native-English-speaking peers. Closing the achievement gap for EL students has been a long-standing goal for California educators, and there are some signs of success. Now that EL funding and curriculum issues are receiving a fresh level of…

  17. The Transliterate Learner

    ERIC Educational Resources Information Center

    Bush, Gail

    2012-01-01

    Thomas et al. have defined transliteracy as "the ability to read, write and interact across a range of platforms, tools and media from signing and orality through handwriting, print, TV, radio and film, to digital social networks" (Transliteracy Research Group). The learner who is transliterate builds knowledge, communicates, and interacts across…

  18. Osteoblast Lineage Cells Play an Essential Role in Periodontal Bone Loss Through Activation of Nuclear Factor-Kappa B

    PubMed Central

    Pacios, Sandra; Xiao, Wenmei; Mattos, Marcelo; Lim, Jason; Tarapore, Rohinton S.; Alsadun, Sarah; Yu, Bo; Wang, Cun-Yu; Graves, Dana T.

    2015-01-01

    Bacterial pathogens stimulate periodontitis, the most common osteolytic disease in humans and the most common cause of tooth loss in adults. Previous studies identified leukocytes and their products as key factors in this process. We demonstrate for the first time that osteoblast lineage cells play a critical role in periodontal disease. Oral infection stimulated nuclear localization of NF-κB in osteoblasts and osteocytes in the periodontium of wild type but not transgenic mice that expressed a lineage specific dominant negative mutant of IKK (IKK-DN) in osteoblast lineage cells. Wild-type mice were also susceptible to bacteria induced periodontal bone loss but transgenic mice were not. The lack of bone loss in the experimental group was linked to reduced RANKL expression by osteoblast lineage cells that led to diminished osteoclast mediated bone resorption and greater coupled new bone formation. The results demonstrate that osteoblast lineage cells are key contributors to periodontal bone loss through an NF-κB mediated mechanism. PMID:26666569

  19. Reactive oxygen species play no role in the candidacidal activity of the salivary antimicrobial peptide histatin 5.

    PubMed

    Veerman, Enno C I; Nazmi, Kamran; Van't Hof, Wim; Bolscher, Jan G M; Den Hertog, Alice L; Nieuw Amerongen, Arie V

    2004-07-15

    The mechanism of action of antimicrobial peptides is still a matter of debate. The formation of ROS (reactive oxygen species) has been suggested to be the crucial step in the fungicidal mechanism of a number of antimicrobial peptides, including histatin 5 and lactoferrin-derived peptides. In the present study we have investigated the effects of histatin 5 and of a more amphipathic synthetic derivative, dhvar4, on the generation of ROS in the yeast Candida albicans, using dihydroethidium as an indicator for ROS. With both peptides, a substantial enhancement of fluorescence was observed. However, TEMPO (2,2,6,6-tetramethylpiperidine-N-oxyl), a cell-permeant ROS scavenger, did not have an inhibitory effect on killing or on the enhancement of fluorescence. Furthermore, antimycin and azide, which have been reported to induce ROS in vitro, were not able to enhance the dihydroethidium fluorescence, while chlorhexidine, a non-specific antiseptic agent, enhanced dihydroethidium fluorescence to the same extent as did the peptides. Fluorescence microscopy showed the fluorescence enhancement to be a consequence of the release of unbound preformed ethidium from the mitochondrial matrix within the cell. It is concluded that ROS do not play a role in the histatin 5-mediated killing of C. albicans. PMID:15109304

  20. Welfare Reform: Work-Site-Based Activities Can Play an Important Role in TANF Programs. Report to Congressional Requesters.

    ERIC Educational Resources Information Center

    Fagnoni, Cynthia M.

    The General Accounting Office (GAO) examined worksite-based activities currently in place to help recipients of Temporary Assistance for Needy Families (TANF) develop the skills required for successful transition to unsubsidized employment. Data were collected from the following sources: (1) data reported by states to the Department of Health and…

  1. 1994 C. H. McCloy Research Lecture: Does Physical Activity Play a Role in Preventing Osteoporosis?

    ERIC Educational Resources Information Center

    Drinkwater, Barbara L.

    1994-01-01

    Review considers problems encountered in relating women's physical activity to increases in bone mass, noting the implications of recommending exercise to help prevent osteoporosis based on that information. Research indicates that for the full benefit of exercise on skeletal health, there must be adequate gonadal hormone levels. (SM)

  2. "Play It Again, Billy, but This Time with More Mistakes": Divergent Improvisation Activities for the Jazz Ensemble

    ERIC Educational Resources Information Center

    Healy, Daniel J.

    2014-01-01

    The jazz ensemble represents an important performance opportunity in many school music programs. Due to the cultural history of jazz as an improvisatory art form, school jazz ensemble directors must address methods of teaching improvisation concepts to young students. Progress has been made in the field of prescribed improvisation activities and…

  3. Activation of the AMPK-ULK1 pathway plays an important role in autophagy during prion infection

    PubMed Central

    Fan, Xue-Yu; Tian, Chan; Wang, Hui; Xu, Yin; Ren, Ke; Zhang, Bao-Yun; Gao, Chen; Shi, Qi; Meng, Ge; Zhang, Lu-Bin; Zhao, Yang-Jing; Shao, Qi-Xiang; Dong, Xiao-Ping

    2015-01-01

    AMPK is a serine/threonine protein kinase that acts as a positive regulator of autophagy, by phosphorylating ULK1 at specific sites. A previous study demonstrated activation of the macroautophagic system in scrapie-infected experimental rodents and in certain human prion diseases, in which the essential negative regulator mTOR is severely inhibited. In this study, AMPK and ULK1 in the brains of hamsters infected with scrapie strain 263 K and in the scrapie-infected cell line SMB-S15 were analysed. The results showed an up-regulated trend of AMPK and AMPK-Thr172, ULK1 and ULK1-Ser555. Increases in brain AMPK and ULK1 occurred at an early stage of agent 263 K infection. The level of phosphorylated ULK1-Ser757 decreased during mid-infection and was only negligibly present at the terminal stage, a pattern that suggested a close relationship of the phosphorylated protein with altered endogenous mTOR. In addition, the level of LKB1 associated with AMPK activation was selectively increased at the early and middle stages of infection. Knockdown of endogenous ULK1 in SMB-S15 cells inhibited LC3 lipidation. These results showed that, in addition to the abolishment of the mTOR regulatory pathway, activation of the AMPK-ULK1 pathway during prion infection contributes to autophagy activation in prion-infected brain tissues. PMID:26423766

  4. Assessment of the nutrition and physical activity education needs of low-income, rural mothers: can technology play a role?

    PubMed

    Atkinson, Nancy L; Billing, Amy S; Desmond, Sharon M; Gold, Robert S; Tournas-Hardt, Amy

    2007-08-01

    The purpose of this study was to examine the perceptions of low-income, rural mothers regarding their need for nutrition and physical activity education and the role of technology in addressing those needs. Quantitative and qualitative research was combined to examine the nature and scope of the issues faced by this target population. Women who were currently receiving food stamps and had children in nursery school to eighth grade were recruited through a state database to participate in a telephone survey (N = 146) and focus groups (N = 56). Low-income, rural mothers were aware of and practiced many health behaviors related to nutrition and physical activity, but they faced additional barriers due to their income level, rural place of residence, and having children. They reported controlling the fat content in the food they cooked and integrating fruits and vegetables but showed less interest in increasing fiber consumption. They reported knowing little about physical activity recommendations, and their reported activity patterns were likely inflated because of seeing housework and child care as exercise. To stretch their food budget, the majority reported practicing typical shopping and budgeting skills, and many reported skills particularly useful in rural areas: hunting, fishing, and canning. Over two-thirds of the survey respondents reported computer access and previous Internet use, and most of those not yet online intended to use the Internet in the future. Those working in rural communities need to consider technology as a way to reach traditionally underserved populations like low-income mothers. PMID:17696049

  5. Who's Calling the Plays?

    ERIC Educational Resources Information Center

    Goldman, Jay P.

    1990-01-01

    Without an enforceable policy, school athletics programs are beset by politics, high finance, and public sentiment. The most nettlesome problems include loss of instructional time to sports and extracurricular activities; the appropriateness and effectiveness of no-pass/no-play rules; lack of sportsmanship; proliferation of interstate competition;…

  6. Which factors play a role in Dutch health promotion professionals’ decision to recruit actively primary schools to use a web-based smoking prevention programme?

    PubMed Central

    2013-01-01

    Background Municipal Health Promotion Organisations (MHPOs) play an important role in promoting and disseminating prevention programmes, such as smoking prevention programmes, in schools. This study identifies factors that may facilitate or hinder MHPOs’ willingness to recruit actively primary schools to use a smoking prevention programme. Methods In 2011, 31 Dutch MHPOs were invited to recruit schools to use a smoking prevention programme. All MHPO employees involved in smoking prevention activities (n = 68) were asked to complete a questionnaire assessing psychological factors and characteristics of their organisation that might affect their decision to be involved in active recruitment of schools. T-tests and multivariate analysis of variance assessed potential differences in psychological and organisational factors between active and non-active recruiters. Results A total of 45 professionals returned the questionnaire (66.2%). Active recruiters (n = 12) had more positive attitudes (p = 0.02), higher self-efficacy expectations (p < 0.01) and formulated more plans (p < 0.01) to recruit primary schools, compared with non-active recruiters. Organisational factors did not discriminate between active and non-active recruiters. Conclusions Primarily psychological factors seem to be associated with MHPOs’ decision to recruit schools actively. This indicates that creating more positive attitude, self-efficacy beliefs and formation of plans may help in getting more MHPOs involved in active recruitment procedures. PMID:24298942

  7. HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity

    PubMed Central

    Semba, Hiroaki; Takeda, Norihiko; Isagawa, Takayuki; Sugiura, Yuki; Honda, Kurara; Wake, Masaki; Miyazawa, Hidenobu; Yamaguchi, Yoshifumi; Miura, Masayuki; Jenkins, Dana M. R.; Choi, Hyunsung; Kim, Jung-whan; Asagiri, Masataka; Cowburn, Andrew S.; Abe, Hajime; Soma, Katsura; Koyama, Katsuhiro; Katoh, Manami; Sayama, Keimon; Goda, Nobuhito; Johnson, Randall S.; Manabe, Ichiro; Nagai, Ryozo; Komuro, Issei

    2016-01-01

    In severely hypoxic condition, HIF-1α-mediated induction of Pdk1 was found to regulate glucose oxidation by preventing the entry of pyruvate into the tricarboxylic cycle. Monocyte-derived macrophages, however, encounter a gradual decrease in oxygen availability during its migration process in inflammatory areas. Here we show that HIF-1α-PDK1-mediated metabolic changes occur in mild hypoxia, where mitochondrial cytochrome c oxidase activity is unimpaired, suggesting a mode of glycolytic reprogramming. In primary macrophages, PKM2, a glycolytic enzyme responsible for glycolytic ATP synthesis localizes in filopodia and lammelipodia, where ATP is rapidly consumed during actin remodelling processes. Remarkably, inhibition of glycolytic reprogramming with dichloroacetate significantly impairs macrophage migration in vitro and in vivo. Furthermore, inhibition of the macrophage HIF-1α-PDK1 axis suppresses systemic inflammation, suggesting a potential therapeutic approach for regulating inflammatory processes. Our findings thus demonstrate that adaptive responses in glucose metabolism contribute to macrophage migratory activity. PMID:27189088

  8. HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity.

    PubMed

    Semba, Hiroaki; Takeda, Norihiko; Isagawa, Takayuki; Sugiura, Yuki; Honda, Kurara; Wake, Masaki; Miyazawa, Hidenobu; Yamaguchi, Yoshifumi; Miura, Masayuki; Jenkins, Dana M R; Choi, Hyunsung; Kim, Jung-Whan; Asagiri, Masataka; Cowburn, Andrew S; Abe, Hajime; Soma, Katsura; Koyama, Katsuhiro; Katoh, Manami; Sayama, Keimon; Goda, Nobuhito; Johnson, Randall S; Manabe, Ichiro; Nagai, Ryozo; Komuro, Issei

    2016-01-01

    In severely hypoxic condition, HIF-1α-mediated induction of Pdk1 was found to regulate glucose oxidation by preventing the entry of pyruvate into the tricarboxylic cycle. Monocyte-derived macrophages, however, encounter a gradual decrease in oxygen availability during its migration process in inflammatory areas. Here we show that HIF-1α-PDK1-mediated metabolic changes occur in mild hypoxia, where mitochondrial cytochrome c oxidase activity is unimpaired, suggesting a mode of glycolytic reprogramming. In primary macrophages, PKM2, a glycolytic enzyme responsible for glycolytic ATP synthesis localizes in filopodia and lammelipodia, where ATP is rapidly consumed during actin remodelling processes. Remarkably, inhibition of glycolytic reprogramming with dichloroacetate significantly impairs macrophage migration in vitro and in vivo. Furthermore, inhibition of the macrophage HIF-1α-PDK1 axis suppresses systemic inflammation, suggesting a potential therapeutic approach for regulating inflammatory processes. Our findings thus demonstrate that adaptive responses in glucose metabolism contribute to macrophage migratory activity. PMID:27189088

  9. Promoting Success for Dual Language Learners: The Essential Role of Early Childhood Education Programs

    ERIC Educational Resources Information Center

    Freedberg, Louis; Frey, Susan

    2016-01-01

    Early childhood education programs in California have a crucial role to play in preparing dual language learners to enter kindergarten with the skills they need to succeed in school and beyond. The reason is simple: there are more dual language learners under the age of 5 in early childhood education programs in California than anywhere else in…

  10. Constructions of Language and Learner Identity in the Classroom: Confessions of a Failure

    ERIC Educational Resources Information Center

    Cruickshank, Ken

    2012-01-01

    Teachers and learners can hold differing ideas about language and goals for language learning which are then played out in classroom interactions. Constructions of what counts as language and learning impact on learner engagement and identity and the outcomes of language learning. This study analyses a researcher's account of the learning of…

  11. Social Interaction within a Web 2.0 Learning Environment: The Impact on Learner Social Presence

    ERIC Educational Resources Information Center

    Steinman, Debbie Cinque

    2010-01-01

    In this case study, the researcher observed the social interactions within a Web 2.0 learning environment to examine the nature of the learner social presence. Social presence is essential to facilitate group cooperation and plays a central role in establishing learners' sense of belonging and social cohesion to the group. Social presence is…

  12. An Intelligent E-Learning System Based on Learner Profiling and Learning Resources Adaptation

    ERIC Educational Resources Information Center

    Tzouveli, Paraskevi; Mylonas, Phivos; Kollias, Stefanos

    2008-01-01

    Taking advantage of the continuously improving, web-based learning systems plays an important role for self-learning, especially in the case of working people. Nevertheless, learning systems do not generally adapt to learners' profiles. Learners have to spend a lot of time before reaching the learning goal that is compatible with their knowledge…

  13. Protein Inhibitor of NOS1 Plays a Central Role in the Regulation of NOS1 Activity in Human Dilated Hearts

    PubMed Central

    Roselló-Lletí, Esther; Tarazón, Estefanía; Ortega, Ana; Gil-Cayuela, Carolina; Carnicer, Ricardo; Lago, Francisca; González-Juanatey, Jose Ramón; Portolés, Manuel; Rivera, Miguel

    2016-01-01

    An essential factor for the production of nitric oxide by nitric oxide synthase 1 (NOS1), major modulator of cardiac function, is the cofactor tetrahydrobiopterin (BH4). BH4 is regulated by GTP cyclohydrolase 1, the rate-limiting enzyme in BH4 biosynthesis which catalyses the formation of dihydroneopterin 3′triphosfate from GTP, producing BH4 after two further steps catalyzed by 6-pyruvoyltetrahydropterin synthase and sepiapterin reductase. However, there are other essential factors involved in the regulation of NOS1 activity, such as protein inhibitor of NOS1 (PIN), calmodulin, heat shock protein 90, and NOS interacting protein. All these molecules have never been analysed in human non-ischemic dilated hearts (DCM). In this study we demonstrated that the upregulation of cardiac NOS1 is not accompanied by increased NOS1 activity in DCM, partly due to the elevated PIN levels and not because of alterations in biopterin biosynthesis. Notably, the PIN concentration was significantly associated with impaired ventricular function, highlighting the importance of this NOS1 activity inhibitor in Ca2+ homeostasis. These results take a central role in the current list of targets for future studies focused on the complex cardiac dysfunction processes through more efficient harnessing of NOS1 signalling. PMID:27481317

  14. Mycobacterial secretion systems ESX-1 and ESX-5 play distinct roles in host cell death and inflammasome activation.

    PubMed

    Abdallah, Abdallah M; Bestebroer, Jovanka; Savage, Nigel D L; de Punder, Karin; van Zon, Maaike; Wilson, Louis; Korbee, Cees J; van der Sar, Astrid M; Ottenhoff, Tom H M; van der Wel, Nicole N; Bitter, Wilbert; Peters, Peter J

    2011-11-01

    During infection of humans and animals, pathogenic mycobacteria manipulate the host cell causing severe diseases such as tuberculosis and leprosy. To understand the basis of mycobacterial pathogenicity, it is crucial to identify the molecular virulence mechanisms. In this study, we address the contribution of ESX-1 and ESX-5--two homologous type VII secretion systems of mycobacteria that secrete distinct sets of immune modulators--during the macrophage infection cycle. Using wild-type, ESX-1- and ESX-5-deficient mycobacterial strains, we demonstrate that these secretion systems differentially affect subcellular localization and macrophage cell responses. We show that in contrast to ESX-1, the effector proteins secreted by ESX-5 are not required for the translocation of Mycobacterium tuberculosis or Mycobacterium marinum to the cytosol of host cells. However, the M. marinum ESX-5 mutant does not induce inflammasome activation and IL-1β activation. The ESX-5 system also induces a caspase-independent cell death after translocation has taken place. Importantly, by means of inhibitory agents and small interfering RNA experiments, we reveal that cathepsin B is involved in both the induction of cell death and inflammasome activation upon infection with wild-type mycobacteria. These results reveal distinct roles for two different type VII secretion systems during infection and shed light on how virulent mycobacteria manipulate the host cell in various ways to replicate and spread. PMID:21957139

  15. ROS play a critical role in the differentiation of alternatively activated macrophages and the occurrence of tumor-associated macrophages

    PubMed Central

    Zhang, Yan; Choksi, Swati; Chen, Kun; Pobezinskaya, Yelena; Linnoila, Ilona; Liu, Zheng-Gang

    2013-01-01

    Differentiation to different types of macrophages determines their distinct functions. Tumor-associated macrophages (TAMs) promote tumorigenesis owing to their proangiogenic and immune-suppressive functions similar to those of alternatively activated (M2) macrophages. We report that reactive oxygen species (ROS) production is critical for macrophage differentiation and that inhibition of superoxide (O2−) production specifically blocks the differentiation of M2 macrophages. We found that when monocytes are triggered to differentiate, O2− is generated and is needed for the biphasic ERK activation, which is critical for macrophage differentiation. We demonstrated that ROS elimination by butylated hydroxyanisole (BHA) and other ROS inhibitors blocks macrophage differentiation. However, the inhibitory effect of ROS elimination on macrophage differentiation is overcome when cells are polarized to classically activated (M1), but not M2, macrophages. More importantly, the continuous administration of the ROS inhibitor BHA efficiently blocked the occurrence of TAMs and markedly suppressed tumorigenesis in mouse cancer models. Targeting TAMs by blocking ROS can be a potentially effective method for cancer treatment. PMID:23752925

  16. Erythroid activator NF-E2, TAL1 and KLF1 play roles in forming the LCR HSs in the human adult β-globin locus.

    PubMed

    Kim, Yea Woon; Yun, Won Ju; Kim, AeRi

    2016-06-01

    The β-like globin genes are developmental stage specifically transcribed in erythroid cells. The transcription of the β-like globin genes requires erythroid specific activators such as GATA-1, NF-E2, TAL1 and KLF1. However, the roles of these activators have not fully elucidated in transcription of the human adult β-globin gene. Here we employed hybrid MEL cells (MEL/ch11) where a human chromosome containing the β-globin locus is present and the adult β-globin gene is highly transcribed by induction. The roles of erythroid specific activators were analyzed by inhibiting the expression of NF-E2, TAL1 or KLF1 in MEL/ch11 cells. The loss of each activator decreased the transcription of human β-globin gene, locus wide histone hyperacetylation and the binding of other erythroid specific activators including GATA-1, even though not affecting the expression of other activators. Notably, sensitivity to DNase I was reduced in the locus control region (LCR) hypersensitive sites (HSs) with the depletion of activators. These results indicate that NF-E2, TAL1 and KLF1, all activators play a primary role in HSs formation in the LCR. It might contribute to the transcription of human adult β-globin gene by allowing the access of activators and cofactors. The roles of activators in the adult β-globin locus appear to be different from the roles in the early fetal locus. PMID:27026582

  17. Techniques: Paying Attention to the Place. Part 1--Activities for Instructors and Adult Learners [and] Part 2--Activities for Planning Places for Adult Learning.

    ERIC Educational Resources Information Center

    Fulton, Rodney D.

    1992-01-01

    This two-part article discusses the role of the physical environment in adult learning. In the first part, two activities--environment introduction and visualization--are discussed as ways to develop an awareness for improving the learning environment. In the second part, two planning activities--mapping and geometric coding--are discussed as ways…

  18. Dihydroceramide-desaturase-1-mediated caspase 9 activation through ceramide plays a pivotal role in palmitic acid-induced HepG2 cell apoptosis.

    PubMed

    Zhu, Qun; Yang, Jianjun; Zhu, Rongping; Jiang, Xin; Li, Wanlian; He, Songqing; Jin, Junfei

    2016-09-01

    In this study, results showed that the inhibition of PA-induced HepG2 cell growth takes place in a time- and concentration-dependent manner, that activation of caspase 9 is necessary for PA-induced HepG2 cell apoptosis, that dihydroceramide desaturase 1 (DES1) plays a key role in PA-mediated caspase 9 and caspase 3 activation, and that palmitoleic acid (POA), an omega-7 monounsaturated fatty acid, reverses PA-induced apoptosis through DES1 → Ceramide → Caspase 9 → Caspase 3 signaling. PMID:27364952

  19. Potassium channel openers and prostacyclin play a crucial role in mediating the vasorelaxant activity of Gynura procumbens

    PubMed Central

    2013-01-01

    Background Previous studies of Gynura procumbens (G. procumbens) have shown that partially purified fractions of the leaves are capable of lowering the blood pressure of rats by inhibiting angiotensin-converting enzymic activity and causing vasodilatation. The objectives of this study were therefore to further purify the active compounds that exhibited selective effects on blood vessels, determine the mechanism of actions, and to qualitatively analyse the putative compounds present. Methods The butanolic fraction (BU) of the crude ethanolic extract was purified using column chromatography to obtain several sub-fractions of different polarities. The in vitro effects of BU and the sub-fractions on vascular tension were subsequently determined using isolated rat thoracic aortic rings. The most potent sub-fraction (F1) alone was then investigated for its mechanisms of the vasorelaxant activity. In another experiment, thin-layer chromatography was used to qualitatively analyse the active compounds found in F1. Results The BU and the sub-fractions ranging from 10-7 to 10-2 g/ml significantly (p < 0.05) inhibited the sustained tonic contractions induced by phenylephrine and potassium chloride in a concentration-dependent manner with various degree of potency. The most potent sub-fraction (F1) antagonised the calcium-induced vasocontractions (1 x 10-4 – 1 x 10-2 M) in calcium-free with high concentration of potassium as well as in calcium- and potassium-free Krebs-Henseleit solutions. Contractions induced by noradrenaline and caffeine were not affected by F1. The vasorelaxing effect caused by F1 was significantly attenuated with preincubation of potassium channel blockers (glibenclamide and 4-aminopyridine) and prostacyclin inhibitor (indomethacin) while it was not affected by preincubation with tetraethylammonium, l-nitro-arginine methyl esther, propanolol, atropine, oxadiazolo quinoxalin one and methylene blue. The qualitative phytochemical analysis of F1

  20. The possibly important role played by Ga2O3 during the activation of GaN photocathode

    NASA Astrophysics Data System (ADS)

    Fu, Xiaoqian; Wang, Honggang; Zhang, Junju; Li, Zhiming; Cui, Shiyao; Zhang, Lejuan

    2015-08-01

    Three different chemical solutions are used to remove the possible contamination on GaN surface, while Ga2O3 is still found at the surface. After thermal annealing at 710 °C in the ultrahigh vacuum (UHV) chamber and activated with Cs/O, all the GaN samples are successfully activated to the effective negative electron affinity (NEA) photocathodes. Among all samples, the GaN sample with the highest content of Ga2O3 after chemical cleaning obtains the highest quantum efficiency. By analyzing the property of Ga2O3, the surface processing results, and electron affinity variations during Cs and Cs/O2 deposition on GaN of other groups, it is suggested that before the adsorption of Cs, Ga2O3 is not completely removed from GaN surface in our samples, which will combine with Cs and lead to a large decrease in electron affinity. Furthermore, the effective NEA is formed for GaN photocathode, along with the surface downward band bending. Based on this assumption, a new dipole model Ga2O3-Cs is suggested, and the experimental effects are explained and discussed.

  1. Bringing meteorology ``alive`` through the use of immersion-based learning activities that emphasize role playing and problem solving

    SciTech Connect

    Glantz, C.S.; Estes, J.C.; Andrews, G.L.

    1993-07-01

    Current research and emerging standards in teaching and learning say that students learning best when information is presented in a meaningful context and when the students are involved in things they care about. At the US Department of Energy`s (DOE) Pacific Northwest Laboratory (PNL), science education programs have been developed that incorporate these concepts. To help students and teachers understand the process of ``doing`` science, we provide immersion-based programs in such technical areas as meteorology, marine sciences, wetland ecology, groundwater hydrology, robotics, lasers materials science, biology, and archaeology. This paper focuses on a meteorology program the authors developed in recent years to support this immersion experience approach. We will discuss how we link meteorology with other subject matter, how we show the relevance of meteorology to real-world problems, and how we immerse student`s and teachers in activities that help them understand how scientists uncover knowledge and solve problems.

  2. Cooperative hydration effect causes thermal unfolding of proteins and water activity plays a key role in protein stability in solutions.

    PubMed

    Miyawaki, Osato; Dozen, Michiko; Hirota, Kaede

    2016-08-01

    The protein unfolding process observed in a narrow temperature range was clearly explained by evaluating the small difference in the enthalpy of hydrogen-bonding between amino acid residues and the hydration of amino acid residue separately. In aqueous solutions, the effect of cosolute on the protein stability is primarily dependent on water activity, aw, the role of which has been long neglected in the literature. The effect of aw on protein stability works as a power law so that a small change in aw is amplified substantially through the cooperative hydration effect. In the present approach, the role of hydrophobic interaction stands behind. This affects protein stability indirectly through the change in solution structure caused by the existence of cosolute. PMID:26896315

  3. NFX1 Plays a Role in Human Papillomavirus Type 16 E6 Activation of NFκB Activity▿

    PubMed Central

    Xu, Mei; Katzenellenbogen, Rachel A.; Grandori, Carla; Galloway, Denise A.

    2010-01-01

    High-risk human papillomavirus (HR HPV) requires differentiating epithelial cells to continue to divide in order to replicate the viral DNA. To achieve this, HPV perturbs several regulatory pathways, including cellular apoptosis and senescence signals. HPV E6 has been identified as a regulator of the NFκB signaling pathway, a pathway important in many cellular processes, as well as regulation of virus-host cell interactions. We report here that NFX1-91, an endogenously expressed transcriptional regulator of human telomerase reverse transcriptase (hTERT) that is targeted by HPV type 16 (HPV16) E6/E6-associated protein (E6AP) for degradation, is also critical for regulation of the NFκB pathway by HPV16 E6. Microarray analysis revealed induction of NFκB-responsive genes and reduction of NFκB inhibitors with knockdown of NFX1-91. Knockdown of NFX1-91 induced downregulation of p105, an NFκB inhibitor in both primary human foreskin keratinocytes (HFKs) and HCT116 cells. Chromatin immunoprecipitation assays further confirmed that NFX1-91 bound to the p105 promoter and upregulated its expression. Similarly, in HPV16 E6-positive cells, reduction of p105 expression was observed, paralleling knockdown of NFX1-91 expression. Overall, our data suggest a mechanism for HPV16 E6 activation of the NFκB pathway through NFX1-91. Also, it provides evidence that NFX1-91 can function as a dual regulator, not only a transcriptional repressor, but also a transcriptional activator, when bound to DNA. PMID:20739528

  4. Are Neutrophil Extracellular Traps Playing a Role in the Parasite Control in Active American Tegumentary Leishmaniasis Lesions?

    PubMed Central

    Morgado, Fernanda Nazaré; Nascimento, Michelle T. C.; Saraiva, Elvira M.; de Oliveira-Ribeiro, Carla; Madeira, Maria de Fátima; da Costa-Santos, Marcela; Vasconcellos, Erica C. F.; F. Pimentel, Maria Ines; Rosandiski Lyra, Marcelo; Schubach, Armando de Oliveira; Conceição-Silva, Fátima

    2015-01-01

    Neutrophil extracellular traps (NETs) have been described as a network of extracellular fibers composed by DNA, histones and various proteins/enzymes. Studies have demonstrated that NETs could be responsible for the trapping and elimination of a variety of infectious agents. In order to verify the presence of NETs in American tegumentary leishmaniasis (ATL) and their relationship with the presence of amastigotes we evaluated active cutaneous lesions of 35 patients before treatment by the detection of parasites, neutrophils (neutrophil elastase) and histones through immunohistochemistry and confocal immunofluorescence. Intact neutrophils could be detected in all ATL lesions. NETs were present in 27 patients (median 1.1; range from 0.1 to 23.5/mm2) with lesion duration ranging from one to seven months. NETs were in close proximity with neutrophils (r = 0.586; p = 0.0001) and amastigotes (r = 0.710; p = 0.0001). Two patterns of NET formation were detected: small homogeneously distributed networks observed in all lesions; and large structures that could be visualized at a lower magnification in lesions presenting at least 20% of neutrophils. Lesions presenting the larger NET formation showed high parasite detection. A correlation between NET size and the number of intact amastigotes was observed (p=0.02). As we detected an association between NET and amastigotes, our results suggest that neutrophil migration and NET formation could be stimulated and maintained by stimuli derived from the parasite burden/parasite antigen in the extracellular environment. The observation of areas containing only antigens not intermingled with NETs (elastase and histone) suggests that the involvement of these structures in the control of parasite burden is a dynamic process in which the formation of NETs is exhausted with the destruction of the parasites. Since NETs were also associated with granulomas, this trapping would favor the activity of macrophages in order to control the parasite

  5. PC-PLC/sphingomyelin synthase activity plays a central role in the development of myogenic tone in murine resistance arteries

    PubMed Central

    Zacharia, Joseph; Fairfax, Seth; Wier, Withrow Gil

    2015-01-01

    Myogenic tone is an intrinsic property of the vasculature that contributes to blood pressure control and tissue perfusion. Earlier investigations assigned a key role in myogenic tone to phospholipase C (PLC) and its products, inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). Here, we used the PLC inhibitor, U-73122, and two other, specific inhibitors of PLC subtypes (PI-PLC and PC-PLC) to delineate the role of PLC in myogenic tone of pressurized murine mesenteric arteries. U-73122 inhibited depolarization-induced contractions (high external K+ concentration), thus confirming reports of nonspecific actions of U-73122 and its limited utility for studies of myogenic tone. Edelfosine, a specific inhibitor of PI-PLC, did not affect depolarization-induced contractions but modulated myogenic tone. Because PI-PLC produces IP3, we investigated the effect of blocking IP3 receptor-mediated Ca2+ release on myogenic tone. Incubation of arteries with xestospongin C did not affect tone, consistent with the virtual absence of Ca2+ waves in arteries with myogenic tone. D-609, an inhibitor of PC-PLC and sphingomyelin synthase, strongly inhibited myogenic tone and had no effect on depolarization-induced contraction. D-609 appeared to act by lowering cytoplasmic Ca2+ concentration to levels below those that activate contraction. Importantly, incubation of pressurized arteries with a membrane-permeable analog of DAG induced vasoconstriction. The results therefore mandate a reexamination of the signaling pathways activated by the Bayliss mechanism. Our results suggest that PI-PLC and IP3 are not required in maintaining myogenic tone, but DAG, produced by PC-PLC and/or SM synthase, is likely through multiple mechanisms to increase Ca2+ entry and promote vasoconstriction. PMID:25888510

  6. Identification of ganglioside GM2 activator playing a role in cancer cell migration through proteomic analysis of breast cancer secretomes.

    PubMed

    Shin, Jihye; Kim, Gamin; Lee, Jong Won; Lee, Ji Eun; Kim, Yoo Seok; Yu, Jong-Han; Lee, Seung-Taek; Ahn, Sei Hyun; Kim, Hoguen; Lee, Cheolju

    2016-06-01

    Cancer cell secretomes are considered a potential source for the discovery of cancer markers. In this study, the secretomes of four breast cancer (BC) cell lines (Hs578T, MCF-7, MDA-MB-231, and SK-BR-3) were profiled with liquid chromatography-tandem mass spectrometry analysis. A total of 1410 proteins were identified with less than 1% false discovery rate, of which approximately 55% (796 proteins) were predicted to be secreted from cells. To find BC-specific proteins among the secreted proteins, data of immunohistochemical staining compiled in the Human Protein Atlas were investigated by comparing the data of BC tissues with those of normal tissues. By applying various criteria, including higher expression level in BC tissues, higher predicted potential of secretion, and sufficient number of tandem mass spectra, 12 biomarker candidate proteins including ganglioside GM2 activator (GM2A) were selected for confirmation. Western blot analysis and ELISA for plasma samples of healthy controls and BC patients revealed elevation of GM2A in BC patients, especially those who were estrogen receptor-negative. Additionally, siRNA-mediated knockdown of GM2A in BC cells decreased migration in vitro, whereas the overexpression of GM2A led to an increase in cell migration. Although GM2A as a diagnostic and prognostic marker in BC should be carefully verified further, this study has established the potential role of GM2A in BC progression. PMID:27002480

  7. Root hairs play a key role in the endophytic colonization of olive roots by Pseudomonas spp. with biocontrol activity.

    PubMed

    Prieto, Pilar; Schilirò, Elisabetta; Maldonado-González, María Mercedes; Valderrama, Raquel; Barroso-Albarracín, Juan Bautista; Mercado-Blanco, Jesús

    2011-08-01

    The use of indigenous bacterial root endophytes with biocontrol activity against soil-borne phytopathogens is an environmentally-friendly and ecologically-efficient action within an integrated disease management framework. The earliest steps of olive root colonization by Pseudomonas fluorescens PICF7 and Pseudomonas putida PICP2, effective biocontrol agents (BCAs) against Verticillium wilt of olive (Olea europaea L.) caused by the fungus Verticillium dahliae Kleb., are here described. A gnotobiotic study system using in vitro propagated olive plants, differential fluorescent-protein tagging of bacteria, and confocal laser scanning microscopy analysis have been successfully used to examine olive roots-Pseudomonas spp. interactions at the single-cell level. In vivo simultaneous visualization of PICF7 and PICP2 cells on/in root tissues enabled to discard competition between the two bacterial strains during root colonization. Results demonstrated that both BCAs are able to endophytically colonized olive root tissues. Moreover, results suggest a pivotal role of root hairs in root colonization by both biocontrol Pseudomonas spp. However, colonization of root hairs appeared to be a highly specific event, and only a very low number of root hairs were effectively colonized by introduced bacteria. Strains PICF7 and PICP2 can simultaneously colonize the same root hair, demonstrating that early colonization of a given root hair by one strain did not hinder subsequent attachment and penetration by the other. Since many environmental factors can affect the number, anatomy, development, and physiology of root hairs, colonization competence and biocontrol effectiveness of BCAs may be greatly influenced by root hair's fitness. Finally, the in vitro study system here reported has shown to be a suitable tool to investigate colonization processes of woody plant roots by microorganisms with biocontrol potential. PMID:21347721

  8. Effects of amphetamine on striatal dopamine release, open-field activity, and play in Fischer 344 and Sprague-Dawley rats.

    PubMed

    Siviy, Stephen M; McDowell, Lana S; Eck, Samantha R; Turano, Alexandra; Akopian, Garnik; Walsh, John P

    2015-12-01

    Previous work from our laboratories has shown that juvenile Fischer 344 (F344) rats are less playful than other strains and also appear to be compromised in dopamine (DA) functioning. To determine whether the dysfunctional play in this strain is associated with deficits in the handling and delivery of vesicular DA, the following experiments assessed the extent to which F344 rats are differentially sensitive to the effects of amphetamine. When exposed to amphetamine, striatal slices obtained from F344 rats showed a small increase in unstimulated DA release when compared with slices from Sprague-Dawley rats; they also showed a more rapid high K+-mediated release of DA. These data provide tentative support for the hypothesis that F344 rats have a higher concentration of cytoplasmic DA than Sprague-Dawley rats. When rats were tested for activity in an open field, F344 rats presented a pattern of results that was consistent with either an enhanced response to amphetamine (3 mg/kg) or a more rapid release of DA (10 mg/kg). Although there was some indication that amphetamine had a dose-dependent differential effect on play in the two strains, play in F344 rats was not enhanced to any degree by amphetamine. Although these results are not consistent with our working hypothesis that F344 rats are less playful because of a deficit in vesicular release of DA, they still suggest that this strain may be a useful model for better understanding the role of DA in social behavior during the juvenile period. PMID:26397758

  9. Membrane cholesterol plays an important role in enteropathogen adhesion and the activation of innate immunity via flagellin-TLR5 signaling.

    PubMed

    Zhou, Mingxu; Duan, Qiangde; Li, Yinchau; Yang, Yang; Hardwidge, Philip R; Zhu, Guoqiang

    2015-08-01

    Lipid rafts are cholesterol- and sphingolipid-rich ordered microdomains distributed in the plasma membrane that participates in mammalian signal transduction pathways. To determine the role of lipid rafts in mediating interactions between enteropathogens and intestinal epithelial cells, membrane cholesterol was depleted from Caco-2 and IPEC-J2 cells using methyl-β-cyclodextrin. Cholesterol depletion significantly reduced Escherichia coli and Salmonella enteritidis adhesion and invasion into intestinal epithelial cells. Complementation with exogenous cholesterol restored bacterial adhesion to basal levels. We also evaluated the role of lipid rafts in the activation of Toll-like receptor 5 signaling by bacterial flagellin. Depleting membrane cholesterol reduced the ability of purified recombinant E. coli flagellin to activate TLR5 signaling in intestinal cells. These data suggest that both membrane cholesterol and lipid rafts play important roles in enteropathogen adhesion and contribute to the activation of innate immunity via flagellin-TLR5 signaling. PMID:25935453

  10. Playground Play: Educational and Inclusive

    ERIC Educational Resources Information Center

    Moore, Lisa

    2011-01-01

    It is easy to understand that fun is one of the key ingredients to any playground activity. But what one may not realize is that play systems--including slides, tunnels, activity panels, and more--encourage a lot more than just fun: there is learning at work in playground play, as well as the opportunity to include children of all abilities in…

  11. Outdoor Play: Combating Sedentary Lifestyles

    ERIC Educational Resources Information Center

    Thigpen, Betsy

    2007-01-01

    Increasingly sedentary lifestyles are contributing to overweight and other health concerns as children spend less and less time outside engaged in active play. Outdoor play provides important opportunities to explore the natural world, interact with peers, engage in vigorous physical activity, and learn about our environment. However, outdoor…

  12. Activation of the nimA protein kinase plays a unique role during mitosis that cannot be bypassed by absence of the bimE checkpoint.

    PubMed Central

    Osmani, A H; O'Donnell, K; Pu, R T; Osmani, S A

    1991-01-01

    Mutation of nimA reversibly arrests cells in late G2 and nimA overexpression promotes premature mitosis. Here we demonstrate that the product of nimA (designated NIMA) has protein kinase activity that can phosphorylate beta-casein but not histone proteins. NIMA kinase activity is cell cycle regulated being 20-fold higher at mitosis when compared to S-phase arrested cells. NIMA activation is normally required in G2 to initiate chromosome condensation, to nucleate spindle pole body microtubules, and to allow an MPM-2 specific mitotic phosphorylation. All three of these mitotic events can occur in the absence of activated NIMA when the bimE gene is mutated (bimE7). However, the bimE7 mutation cannot completely bypass the requirement for nimA during mitosis as entry into mitosis in the absence of NIMA activation results in major mitotic defects that affect both the organization of the nuclear envelope and mitotic spindle. Thus, although nimA plays an essential but limited role during mitosis, mutation of nimA arrests all of mitosis. We therefore propose that mutation of nimA prevents mitotic initiation due to a checkpoint arrest that is negatively mediated by bimE. The checkpoint ensures that mitosis is not initiated until NIMA is mitotically activated. Images PMID:1868838

  13. EsxA membrane-permeabilizing activity plays a key role in mycobacterial cytosolic translocation and virulence: effects of single-residue mutations at glutamine 5

    PubMed Central

    Zhang, Qi; Wang, Decheng; Jiang, Guozhong; Liu, Wei; Deng, Qing; Li, Xiujun; Qian, Wei; Ouellet, Hugues; Sun, Jianjun

    2016-01-01

    EsxA is required for virulence of Mycobacterium tuberculosis (Mtb) and plays an essential role in phagosome rupture and translocation to the cytosol of macrophages. Recent biochemical studies have demonstrated that EsxA is a membrane-permeabilizing protein. However, evidence that link EsxA membrane-permeabilizing activity to Mtb cytosolic translocation and virulence is lacking. Here we found that mutations at glutamine 5 (Q5) could up or down regulate EsxA membrane-permeabilizing activity. The mutation Q5K significantly diminished the membrane-permeabilizing activity, while Q5V enhanced the activity. By taking advantage of the single-residue mutations, we tested the effects of EsxA membrane-permeabilizing activity on mycobacterial virulence and cytosolic translocation using the esxA/esxB knockout strains of Mycobacterium marinum (Mm) and Mtb. Compared to wild type (WT), the Q5K mutant exhibited significantly attenuated virulence, evidenced by intracellular survival and cytotoxicity in mouse macrophages as well as infection of zebra fish embryos. The attenuated virulence of the Q5K mutant was correlated to the impaired cytosolic translocation. On the contrary, the Q5V mutant had a significantly increased cytosolic translocation and showed an overall increased virulence. This study provides convincing evidence that EsxA contributes to mycobacterial virulence with its membrane-permeabilizing activity that is required for cytosolic translocation. PMID:27600772

  14. EsxA membrane-permeabilizing activity plays a key role in mycobacterial cytosolic translocation and virulence: effects of single-residue mutations at glutamine 5.

    PubMed

    Zhang, Qi; Wang, Decheng; Jiang, Guozhong; Liu, Wei; Deng, Qing; Li, Xiujun; Qian, Wei; Ouellet, Hugues; Sun, Jianjun

    2016-01-01

    EsxA is required for virulence of Mycobacterium tuberculosis (Mtb) and plays an essential role in phagosome rupture and translocation to the cytosol of macrophages. Recent biochemical studies have demonstrated that EsxA is a membrane-permeabilizing protein. However, evidence that link EsxA membrane-permeabilizing activity to Mtb cytosolic translocation and virulence is lacking. Here we found that mutations at glutamine 5 (Q5) could up or down regulate EsxA membrane-permeabilizing activity. The mutation Q5K significantly diminished the membrane-permeabilizing activity, while Q5V enhanced the activity. By taking advantage of the single-residue mutations, we tested the effects of EsxA membrane-permeabilizing activity on mycobacterial virulence and cytosolic translocation using the esxA/esxB knockout strains of Mycobacterium marinum (Mm) and Mtb. Compared to wild type (WT), the Q5K mutant exhibited significantly attenuated virulence, evidenced by intracellular survival and cytotoxicity in mouse macrophages as well as infection of zebra fish embryos. The attenuated virulence of the Q5K mutant was correlated to the impaired cytosolic translocation. On the contrary, the Q5V mutant had a significantly increased cytosolic translocation and showed an overall increased virulence. This study provides convincing evidence that EsxA contributes to mycobacterial virulence with its membrane-permeabilizing activity that is required for cytosolic translocation. PMID:27600772

  15. Feedback: Enhancing the Performance of Adult Learners with Learning Disabilities.

    ERIC Educational Resources Information Center

    Riviere, Adrienne

    This pamphlet discusses the pivotal role that feedback can play in the instruction of adult learners with learning disabilities and provides strategies to enable teachers to constructively design and present effective feedback. The paper begins by describing and instructional techniques that can be used to create interest and provide feedback…

  16. Research-Based Vocabulary Instruction for English Language Learners

    ERIC Educational Resources Information Center

    Chung, Stephanie F.

    2012-01-01

    A major reading-achievement gap exists between English language learners and English-only students. In order for ELLs to experience school success, they must achieve English language proficiency. This article presents why vocabulary acquisition plays the most vital role in ELLs' learning of the English language. Factors include the severity and…

  17. Pun Work Helps English Learners Get the Joke

    ERIC Educational Resources Information Center

    Lems, Kristin

    2011-01-01

    Native speakers of a language learn word play as part of the language acquisition process, but learners of a new language rarely get that opportunity. English has an unusually large number of opportunities for humorous puns, based on the complex system of spellings, pronunciations, and meanings of English words. There are three main categories of…

  18. Conciencia Con Compromiso: Aspirantes as Bridges for Latin@ Bilingual Learners

    ERIC Educational Resources Information Center

    Prieto, Linda

    2014-01-01

    The study examined the influence of culture on the desire of a group of six aspirantes (Spanish/English bilingual education teacher candidates) from Texas to become bilingual education teachers of Latin@ bilingual learners. Chicana/Latina feminist thought is utilized as a lens to understand the role teacher education programs can play in helping…

  19. Words, Words, Words: Reading Shakespeare with English Language Learners

    ERIC Educational Resources Information Center

    Porter, Christina

    2009-01-01

    In 2006, the author returned to school after completing the Teaching Shakespeare Institute at the Folger Library inspired with new performance-based ideas for teaching the plays. The author began to wonder about using Shakespeare as a vehicle for investigating "rich and strange" language with English Language Learners (ELLs). The author began by…

  20. Learner Preferences and Achievement Under Differing Amounts of Learner Practice.

    ERIC Educational Resources Information Center

    Schnackenberg, Heidi L.; Sullivan, Howard J.; Leader, Lars F.; Jones, Elizabeth E. K.

    1998-01-01

    Examines the effects of program mode (i.e., a lean program version containing a basic amount of learner practice versus a full mode containing expanded practice) and learner preference (matched or unmatched) for amount of practice on the achievement, time-in-program, and attitudes of university undergraduate students. Students preferred the lean…

  1. The nuclear protein GmbZIP110 has transcription activation activity and plays important roles in the response to salinity stress in soybean

    PubMed Central

    Xu, Zhaolong; Ali, Zulfiqar; Xu, Ling; He, Xiaolan; Huang, Yihong; Yi, Jinxin; Shao, Hongbo; Ma, Hongxiang; Zhang, Dayong

    2016-01-01

    Plant basic-leucine zipper (bZIP) transcription factors play important roles in many biological processes and are involved in the regulation of salt stress tolerance. Previously, our lab generated digital gene expression profiling (DGEP) data to identify differentially expressed genes in a salt-tolerant genotype of Glycine soja (STGoGS) and a salt-sensitive genotype of Glycine max (SSGoGM). This DGEP data revealed that the expression (log2 ratio) of GmbZIP110 was up-regulated 2.76-fold and 3.38-fold in SSGoGM and STGoGS, respectively. In the present study, the salt inducible gene GmbZIP110 was cloned and characterized through phylogenetic analysis, subcellular localization and in silico transcript abundance analysis in different tissues. The functional role of this gene in salt tolerance was studied through transactivation analysis, DNA binding ability, expression in soybean composite seedlings and transgenic Arabidopsis, and the effect of GmbZIP110 on the expression of stress-related genes in transgenic Arabidopsis was investigated. We found that GmbZIP110 could bind to the ACGT motif, impact the expression of many stress-related genes and the accumulation of proline, Na+ and K+, and enhanced the salt tolerance of composite seedlings and transgenic Arabidopsis. Integrating all these results, we propose that GmbZIP110 plays a critical role in the response to salinity stress in soybean and has high potential usefulness in crop improvement. PMID:26837841

  2. The nuclear protein GmbZIP110 has transcription activation activity and plays important roles in the response to salinity stress in soybean.

    PubMed

    Xu, Zhaolong; Ali, Zulfiqar; Xu, Ling; He, Xiaolan; Huang, Yihong; Yi, Jinxin; Shao, Hongbo; Ma, Hongxiang; Zhang, Dayong

    2016-01-01

    Plant basic-leucine zipper (bZIP) transcription factors play important roles in many biological processes and are involved in the regulation of salt stress tolerance. Previously, our lab generated digital gene expression profiling (DGEP) data to identify differentially expressed genes in a salt-tolerant genotype of Glycine soja (STGoGS) and a salt-sensitive genotype of Glycine max (SSGoGM). This DGEP data revealed that the expression (log2 ratio) of GmbZIP110 was up-regulated 2.76-fold and 3.38-fold in SSGoGM and STGoGS, respectively. In the present study, the salt inducible gene GmbZIP110 was cloned and characterized through phylogenetic analysis, subcellular localization and in silico transcript abundance analysis in different tissues. The functional role of this gene in salt tolerance was studied through transactivation analysis, DNA binding ability, expression in soybean composite seedlings and transgenic Arabidopsis, and the effect of GmbZIP110 on the expression of stress-related genes in transgenic Arabidopsis was investigated. We found that GmbZIP110 could bind to the ACGT motif, impact the expression of many stress-related genes and the accumulation of proline, Na(+) and K(+), and enhanced the salt tolerance of composite seedlings and transgenic Arabidopsis. Integrating all these results, we propose that GmbZIP110 plays a critical role in the response to salinity stress in soybean and has high potential usefulness in crop improvement. PMID:26837841

  3. Mannose binding lectin plays a crucial role in innate immunity against yeast by enhanced complement activation and enhanced uptake of polymorphonuclear cells

    PubMed Central

    van Asbeck, Eveline C; Hoepelman, Andy IM; Scharringa, Jelle; Herpers, Bjorn L; Verhoef, Jan

    2008-01-01

    Background Mannose binding lectin (MBL) is an important host defence protein against opportunistic fungal pathogens. This carbohydrate-binding protein, an opsonin and lectin pathway activator, binds through multiple lectin domains to the repeating sugar arrays displayed on the surface of a wide range of clinically relevant microbial species. We investigated the contribution of MBL to antifungal innate immunity towards C. parapsilosis in vitro. Results High avidity binding was observed between MBL and C. albicans and C. parapsilosis. Addition of MBL to MBL deficient serum increased the deposition of C4 and C3b and enhanced the uptake of C. albicans, C. parapsilosis and acapsular C. neoformans by polymorphonuclear cells (PMNs). Compared to other microorganisms, such as Escherichia coli, Staphylococcus aureus and Cryptococcus neoformans, C. parapsilosis and Candida albicans were potent activators of the lectin pathway. Conclusion Our results suggest that MBL plays a crucial role in the innate immunity against infections caused by yeast by increasing uptake by PMN. PMID:19094203

  4. Play Therapy: A Review

    ERIC Educational Resources Information Center

    Porter, Maggie L.; Hernandez-Reif, Maria; Jessee, Peggy

    2009-01-01

    This article discusses the current issues in play therapy and its implications for play therapists. A brief history of play therapy is provided along with the current play therapy approaches and techniques. This article also touches on current issues or problems that play therapists may face, such as interpreting children's play, implementing…

  5. Grammatical Processing in Language Learners

    ERIC Educational Resources Information Center

    Clahsen, Harald; Felser, Claudia

    2006-01-01

    The ability to process the linguistic input in real time is crucial for successfully acquiring a language, and yet little is known about how language learners comprehend or produce language in real time. Against this background, we have conducted a detailed study of grammatical processing in language learners using experimental psycholinguistic…

  6. Learner Autonomy and New Technologies.

    ERIC Educational Resources Information Center

    Raya, Manuel Jimenez; Fernandez, Jose Maria Perez

    2002-01-01

    Presents paths for theoretical research and practical procedures that may help teachers make new technology pedagogically relevant. Discusses the need to develop learner autonomy to help students process information in meaningful ways and become independent learners by developing effective learning strategies, transfer skills, and a greater sense…

  7. The Generative Adolescent Mathematical Learner

    ERIC Educational Resources Information Center

    Lawler, Brian R.

    2010-01-01

    The purpose of this paper is to consider the personal epistemologies of generative adolescent mathematical learners. A generative disposition defined a learner who operated mathematically in ways that reflect an internalized authority for knowing and a constructive orientation to knowledge. Drawing upon the radical constructivist teaching…

  8. Chinese English Learners' Strategic Competence

    ERIC Educational Resources Information Center

    Wang, Dianjian; Lai, Hongling; Leslie, Michael

    2015-01-01

    The present study aims to investigate Chinese English learners' ability to use communication strategies (CSs). The subjects are put in a relatively real English referential communication setting and the analyses of the research data show that Chinese English learners, when encountering problems in foreign language (FL) communication, are…

  9. Sensitizing ESL Learners to Genre

    ERIC Educational Resources Information Center

    Swami, Jasti Appa

    2008-01-01

    This article evaluates the efficacy of explicit genre-based instruction by sensitizing the ESL learners to the concept of genre. The main questions addressed are: How does sensitizing ESL learners to the rhetorical move structure of a genre, the communicative purposes of these moves, and linguistic features that realize these moves help them to…

  10. Iranian EFL Learners' Compliment Responses

    ERIC Educational Resources Information Center

    Allami, Hamid; Montazeri, Maryam

    2012-01-01

    The present study aimed at examining the knowledge of Iranian EFL learners in responding to compliments in English, with a focus on the variables of gender, age and educational background. The data were collected through a 24-item English Discourse Completion Task (DCT) to which 40 male and female EFL learners were asked to provide short…

  11. High Ability and Learner Characteristics

    ERIC Educational Resources Information Center

    Hindal, Huda; Reid, Norman; Whitehead, Rex

    2013-01-01

    The outstandingly able learner has been conceptualised, in terms of test and examination performance, as the learner showing superior academic performance which is markedly better than that of peers and in ways regarded as of value by wider society. In Kuwait, such superior examination performance leads to a classification regarded as being…

  12. The Adult Learner: Four Aspects.

    ERIC Educational Resources Information Center

    Lucas, John A., Ed.

    1986-01-01

    Topics concerning the adult learner that are relevant to institutional researchers are addressed in four articles: marketing, predicting success for adult students, enrollment projection, and follow-up studies of adult learners. In "Institutional Research in Support of Marketing the Adult Student," Lydia Jurand notes the importance of identifying…

  13. Profiling Mobile English Language Learners

    ERIC Educational Resources Information Center

    Byrne, Jason; Diem, Robert

    2014-01-01

    The purpose of this study was to use an app-embedded survey to profile language learner demographics. A total of 3,759 EFL language learners from primarily eight L1 backgrounds (French, German, Italian, Japanese, Korean, Russian, Spanish and Thai) responded to the survey embedded within a popular English grammar app. This app has over 500,000…

  14. Assistive Software for Disabled Learners

    ERIC Educational Resources Information Center

    Clark, Sharon; Baggaley, Jon

    2004-01-01

    Previous reports in this series (#32 and 36) have discussed online software features of value to disabled learners in distance education. The current report evaluates four specific assistive software products with useful features for visually and hearing impaired learners: "ATutor", "ACollab", "Natural Voice", and "Just Vanilla". The evaluative…

  15. Motivation Classification and Grade Prediction for MOOCs Learners

    PubMed Central

    Xu, Bin; Yang, Dan

    2016-01-01

    While MOOCs offer educational data on a new scale, many educators find great potential of the big data including detailed activity records of every learner. A learner's behavior such as if a learner will drop out from the course can be predicted. How to provide an effective, economical, and scalable method to detect cheating on tests such as surrogate exam-taker is a challenging problem. In this paper, we present a grade predicting method that uses student activity features to predict whether a learner may get a certification if he/she takes a test. The method consists of two-step classifications: motivation classification (MC) and grade classification (GC). The MC divides all learners into three groups including certification earning, video watching, and course sampling. The GC then predicts a certification earning learner may or may not obtain a certification. Our experiment shows that the proposed method can fit the classification model at a fine scale and it is possible to find a surrogate exam-taker. PMID:26884747

  16. Zinc-finger protein 91 plays a key role in LIGHT-induced activation of non-canonical NF-{kappa}B pathway

    SciTech Connect

    Jin, Hong Ri; Jin, Xuejun; Lee, Jung Joon

    2010-10-01

    Research highlights: {yields} LIGHT induces ZFP91expression and nuclear translocation of p65, p52, and RelB in LT{beta}R signaling. {yields} ZFP91 knock-down abolishes DNA-binding activity of p52 and RelB but not of p65. {yields} ZFP91 regulates LIGHT-induced stabilization and activation of NIK. {yields} ZFP91 is required for the expression of non-canonical NF-{kappa}B target genes. -- Abstract: LIGHT is a member of tumor necrosis factor (TNF) superfamily, and its function is mediated through lymphotoxin-{beta} receptor (LT{beta}R), which is known to play important roles in inflammatory and immune responses through activation of NF-{kappa}B signaling pathways. However, molecular mechanism of LT{beta}R ligation-induced NF-{kappa}B signaling remains incompletely understood. In this report we demonstrate that a novel zinc-finger protein 91 (ZFP91) is a critical regulator in LIGHT-induced activation of non-canonical NF-{kappa}B pathway. ZFP91 appears to be required for NF-{kappa}B2 (p100) processing to p52, nuclear translocation of p52 and RelB, and DNA-binding activity of NF-{kappa}B in LIGHT-induced activation of non-canonical NF-{kappa}B pathway. Furthermore, ZFP91 knock-down by RNA interference blocks the LIGHT-induced accumulation of NIK and p100 processing, as well as the expression of non-canonical NF-{kappa}B target genes. These data clearly indicate that ZFP91 is a key regulator in LIGHT-induced activation of non-canonical NF-{kappa}B pathway in LT{beta}R signaling.

  17. Shrimp Serine Proteinase Homologues PmMasSPH-1 and -2 Play a Role in the Activation of the Prophenoloxidase System

    PubMed Central

    Jearaphunt, Miti; Amparyup, Piti; Sangsuriya, Pakkakul; Charoensapsri, Walaiporn; Senapin, Saengchan; Tassanakajon, Anchalee

    2015-01-01

    Melanization mediated by the prophenoloxidase (proPO) activating system is a rapid immune response used by invertebrates against intruding pathogens. Several masquerade-like and serine proteinase homologues (SPHs) have been demonstrated to play an essential role in proPO activation in insects and crustaceans. In a previous study, we characterized the masquerade-like SPH, PmMasSPH1, in the black tiger shrimp Penaeus monodon as a multifunctional immune protein based on its recognition and antimicrobial activity against the Gram-negative bacteria Vibrio harveyi. In the present study, we identify a novel SPH, known as PmMasSPH2, composed of an N-terminal clip domain and a C-terminal SP-like domain that share high similarity to those of other insect and crustacean SPHs. We demonstrate that gene silencing of PmMasSPH1 and PmMasSPH2 significantly reduces PO activity, resulting in a high number of V. harveyi in the hemolymph. Interestingly, knockdown of PmMasSPH1 suppressed not only its gene transcript but also other immune-related genes in the proPO system (e.g., PmPPAE2) and antimicrobial peptides (e.g., PenmonPEN3, PenmonPEN5, crustinPm1 and Crus-likePm). The PmMasSPH1 and PmMasSPH2 also show binding activity to peptidoglycan (PGN) of Gram-positive bacteria. Using a yeast two-hybrid analysis and co-immunoprecipitation, we demonstrate that PmMasSPH1 specifically interacted with the final proteinase of the proPO cascade, PmPPAE2. Furthermore, the presence of both PmMasSPH1 and PmPPAE2 enhances PGN-induced PO activity in vitro. Taken together, these results suggest the importance of PmMasSPHs in the activation of the shrimp proPO system. PMID:25803442

  18. MOZ and BMI1 play opposing roles during Hox gene activation in ES cells and in body segment identity specification in vivo.

    PubMed

    Sheikh, Bilal N; Downer, Natalie L; Phipson, Belinda; Vanyai, Hannah K; Kueh, Andrew J; McCarthy, Davis J; Smyth, Gordon K; Thomas, Tim; Voss, Anne K

    2015-04-28

    Hox genes underlie the specification of body segment identity in the anterior-posterior axis. They are activated during gastrulation and undergo a dynamic shift from a transcriptionally repressed to an active chromatin state in a sequence that reflects their chromosomal location. Nevertheless, the precise role of chromatin modifying complexes during the initial activation phase remains unclear. In the current study, we examined the role of chromatin regulators during Hox gene activation. Using embryonic stem cell lines lacking the transcriptional activator MOZ and the polycomb-family repressor BMI1, we showed that MOZ and BMI1, respectively, promoted and repressed Hox genes during the shift from the transcriptionally repressed to the active state. Strikingly however, MOZ but not BMI1 was required to regulate Hox mRNA levels after the initial activation phase. To determine the interaction of MOZ and BMI1 in vivo, we interrogated their role in regulating Hox genes and body segment identity using Moz;Bmi1 double deficient mice. We found that the homeotic transformations and shifts in Hox gene expression boundaries observed in single Moz and Bmi1 mutant mice were rescued to a wild type identity in Moz;Bmi1 double knockout animals. Together, our findings establish that MOZ and BMI1 play opposing roles during the onset of Hox gene expression in the ES cell model and during body segment identity specification in vivo. We propose that chromatin-modifying complexes have a previously unappreciated role during the initiation phase of Hox gene expression, which is critical for the correct specification of body segment identity. PMID:25922517

  19. Reducing sedentary behaviour and increasing physical activity among 10-year-old children: overview and process evaluation of the 'Switch-Play' intervention.

    PubMed

    Salmon, Jo; Ball, Kylie; Crawford, David; Booth, Michael; Telford, Amanda; Hume, Clare; Jolley, Damien; Worsley, Anthony

    2005-03-01

    Overweight and obesity has doubled among children in Australia. There is an urgent need to develop primary prevention strategies to prevent current and future unhealthy weight gain. The aims of this paper are to describe a randomized controlled trial ('Switch-Play') developed to prevent unhealthy weight gain among 10-year-old children and to report the findings of the process evaluation. Children from three government primary schools were randomized by class to one of four conditions: a behavioural modification group (BM; n = 69); a fundamental motor skills group (FMS; n = 73); a combined BM and FMS group (n = 90); or a control (usual classroom lessons) group (n = 61). Children in the BM group participated in 19 sessions that encouraged them to reduce screen-based behaviours, and identified physical activity alternatives. The FMS group participated in 19 lessons that focused on mastery of six skills: run, throw, dodge, strike, vertical jump and kick. The combined group participated in all the BM and FMS activities. The intervention specialist teacher reported that the children showed high enjoyment and engagement (88% lessons attended) in most aspects of the programme. At-home tasks were completed by 57-62% of the children, and 92% completed the in-class tasks. Two-thirds of the children in the BM group participated in the behavioural contracting to switch off the TV. Most of the children reported high enjoyment of the programmes, and only a small proportion (7-17%) reported difficulties in switching off their nominated TV shows. More than half the children reported reducing their TV viewing; however, less than half reported increasing their physical activity. It was found that most aspects of the intervention arms of the programme were successfully delivered to the majority of children participating in 'Switch-Play'; that the programmes were delivered as intended; and that the programmes were favourably evaluated by participating children and their parents. PMID

  20. Methods and baseline characteristics of a randomized trial treating early childhood obesity: The Positive Lifestyles for Active Youngsters (Team PLAY) trial

    PubMed Central

    Hare, Marion; Coday, Mace; Williams, Natalie A.; Richey, Phyllis; Tylavsky, Frances; Bush, Andrew

    2012-01-01

    There are few effective obesity interventions directed towards younger children, particularly young minority children. This paper describes the design, intervention, recruitment methods, and baseline data of the ongoing Positive Lifestyles for Active Youngsters (Team PLAY) study. This randomized controlled trial is designed to test the efficacy of a 6-month, moderately intense, primary care feasible, family-based behavioral intervention, targeting both young children and their parent, in promoting healthy weight change. Participants are 270 overweight and obese children (ages 4 to 7 years) and their parent, who were recruited from a primarily African American urban population. Parents and children were instructed in proven cognitive behavioral techniques (e.g. goal setting, self-talk, stimulus control and reinforcement) designed to encourage healthier food choices (more whole grains, fruits and vegetables, and less concentrated fats and sugar), reduce portion sizes, decrease sweetened beverages and increase moderate to vigorous physical activity engagement. The main outcome of this study is change in BMI at two years post enrollment. Recruitment using reactive methods (mailings, TV ads, pamphlets) was found to be more successful than using only a proactive approach (referral through physicians). At baseline, most children were very obese with an average BMI z-score of 2.6. Reported intake of fruits and vegetables and minutes of moderate to vigorous physical activity engagement did not meet national recommendations. If efficacious, Team PLAY would offer a model for obesity treatment directed at families with young children that could be tested and translated to both community and primary care settings. PMID:22342450