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Sample records for activity log mal

  1. The ATP-binding cassette subunit of the maltose transporter MalK antagonizes MalT, the activator of the Escherichia coli mal regulon.

    PubMed

    Panagiotidis, C H; Boos, W; Shuman, H A

    1998-11-01

    Transcription of the mal regulon of Escherichia coli K-12 is regulated by the positive activator, MalT. In the presence of ATP and maltotriose, MalT binds to decanucleotide MalT boxes that are found upstream of mal promoters and activates transcription at these sites. The earliest studies of the mal regulon, however, suggested a negative role for the MalK protein, the ATP-binding cassette subunit of the maltose transporter, in regulating mal gene expression. More recently, it was found that overexpression of the MalK protein resulted in very low levels of mal gene transcription. In this report we describe the use of tagged versions of MalT to provide evidence that it physically interacts with the MalK protein both in vitro and in vivo. In addition, we show that a novel malK mutation, malK941, results in an increased ability of MalK to down-modulate MalT activity in vivo. The fact that the MalK941 protein binds but does not hydrolyse ATP suggests that the MalK941 mutant protein mimics the inactive, ATP-bound form of the normal MalK protein. In contrast, cells with high levels of MalK ATPase show a reduced ability to down-modulate MalT and express several mal genes constitutively. These results are consistent with a model in which the inactive form of MalK down-modulates MalT and decreases transcription, whereas the active form of MalK does not. This model suggests that bacteria may be able to couple information about extracellular substrate availability to the transcriptional apparatus via the levels of ATP hydrolysis associated with transport. PMID:9822819

  2. Functional domain analysis of the Saccharomyces MAL-activator.

    PubMed

    Hu, Z; Gibson, A W; Kim, J H; Wojciechowicz, L A; Zhang, B; Michels, C A

    1999-08-01

    MAL63 of the MAL6 locus and its homologues at the other MAL loci encode transcription activators required for the maltose-inducible expression of the MAL structural genes. We carried out a deletion analysis of LexA-MAL63 gene fusions to localize the functional domains of the Mal63 MAL-activator protein. Our results indicate that the sequence-specific DNA-binding domain of Mal63p is contained in residues 1-100; that residues 60-283 constitute a functional core region including the transactivation domain; that residues 251-299 are required to inhibit the activation function of Mal63p; and that the rest of the C-terminal region of the protein contains a maltose-responsive domain that acts to relieve the inhibitory effect on the activation function. Abundant overproduction of Mal63p does not overcome the negative regulation of MAL gene expression in the absence of maltose, suggesting that a titratable MAL-specific repressor similar to Gal80p is not involved in the negative regulation of the MAL-activator. A model for maltose-inducible autoregulation of the MAL-activator is presented. PMID:10447589

  3. The N terminus of the Escherichia coli transcription activator MalT is the domain of interaction with MalY.

    PubMed

    Schlegel, Anja; Danot, Olivier; Richet, Evelyne; Ferenci, Thomas; Boos, Winfried

    2002-06-01

    The maltose system of Escherichia coli consists of a number of genes encoding proteins involved in the uptake and metabolism of maltose and maltodextrins. The system is positively regulated by MalT, its transcriptional activator. MalT activity is controlled by two regulatory circuits: a positive one with maltotriose as effector and a negative one involving several proteins. MalK, the ATP-hydrolyzing subunit of the cognate ABC transporter, MalY, an enzyme with the activity of a cystathionase, and Aes, an acetyl esterase, phenotypically act as repressors of MalT activity. By in vivo titration assays, we have shown that the N-terminal 250 amino acids of MalT contain the interaction site for MalY but not for MalK. This was confirmed by gel filtration analysis, where MalY was shown to coelute with the N-terminal MalT structural domain. Mutants in MalT causing elevated mal gene expression in the absence of exogenous maltodextrins were tested in their response to the three repressors. The different MalT mutations exhibited a various degree of sensitivity towards these repressors, but none was resistant to all of them. Some of them became nearly completely resistant to Aes while still being sensitive to MalY. These mutations are located at positions 38, 220, 243, and 359, most likely defining the interaction patch with Aes on the three-dimensional structure of MalT. PMID:12003949

  4. Clustered-charge to alanine scanning mutagenesis of the Mal63 MAL-activator C-terminal regulatory domain.

    PubMed

    Danzi, Sara E; Bali, Mehtap; Michels, Corinne A

    2003-12-01

    The MAL-activator genes of Saccharomyces cerevisiae encode regulatory proteins required for the expression of the structural genes encoding maltose permease and maltase. Residues within the C-terminal region of the Mal63 protein required for negative regulation were previously identified. Evidence suggested that the C-terminal domain is also involved in positive regulatory functions, such as inducer responsiveness and transactivation in the context of a full-length protein. Charged-cluster to alanine scanning mutagenesis of the regulatory domain of MAL63 and the constitutive MAL43-C were undertaken to identify distinct regions within Mal63p involved in positive functions and to define their roles in induction. Mutations that affect the ability to activate transcription in the inducible MAL63 but have no effect in the constitutive MAL43-C define regions that function in induction. Those that affect both the inducible and constitutive alleles define regions involved in activation more generally. Mutations in MAL63 fell into three classes, those that have little or no impact on activity, those that decrease activity, and those that enhance function. Mutations from these classes mapped to distinct regions of the protein, identifying a region of approximately 90 residues (residues 331-423) involved in maltose sensing and an approximately 50-residue region at the extreme C-terminus (residues 420-470) required for activation, such as the formation and/or maintenance of an active state. These studies support a model for MAL-activator function which involves complex protein-protein interactions and overlapping negative and positive regulatory regions. PMID:14508602

  5. The Hsp90 molecular chaperone complex regulates maltose induction and stability of the Saccharomyces MAL gene transcription activator Mal63p.

    PubMed

    Bali, Mehtap; Zhang, Bin; Morano, Kevin A; Michels, Corinne A

    2003-11-28

    Induction of the Saccharomyces MAL structural genes encoding maltose permease and maltase requires the MAL activator, a DNA-binding transcription activator. Genetic analysis of MAL activator mutations suggested that protein folding and stability play an important role in MAL activator regulation and led us to explore the role of the Hsp90 molecular chaperone complex in the regulation of the MAL activator. Strains carrying mutations in genes encoding components of the Hsp90 chaperone complex, hsc82 Delta hsp82-T101I and hsc82 Delta cpr7 Delta, are defective for maltase induction and exhibit significantly reduced growth rates on media containing a limiting concentration of maltose (0.05%). This growth defect is suppressed by providing maltose in excess. Using epitope-tagged alleles of the MAL63 MAL activator, we showed that Mal63p levels are drastically reduced following depletion of cellular Hsp90. Overexpression ( approximately 3-fold) of Mal63p in the hsc82 Delta hsp82-T101I and hsc82 Delta cpr7 Delta strains suppresses their Mal- growth phenotype, suggesting that Mal63p levels are limiting for maltose utilization in strains with abrogated Hsp90 activity. Consistent with this, the half-life of Mal63p is significantly shorter in the hsc82 Delta cpr7 Delta strain (reduced about 6-fold) and modestly affected in the Hsp90-ts strain (reduced about 2-fold). Most importantly, triple hemagglutinin-tagged Mal63p protein is found in association with Hsp90 as demonstrated by co-immunoprecipitation. Taken together, these results identify the inducible MAL activator as a client protein of the Hsp90 molecular chaperone complex and point to a critical role for chaperone function in alternate carbon source utilization in Saccharomyces cerevisiae. PMID:14500708

  6. The UAS(MAL) is a bidirectional promotor element required for the expression of both the MAL61 and MAL62 genes of the Saccharomyces MAL6 locus.

    PubMed

    Levine, J; Tanouye, L; Michels, C A

    1992-09-01

    Maltose fermentation in Saccharomyces yeasts requires one of five unlinked MAL loci: MAL1, 2, 3, 4, or 6. Each locus consists of three genes encoding maltose permease, maltase and the MAL activator. At MAL6 the genes are called MAL61, MAL62 and MAL63, respectively. Transcription of MAL61 and MAL62 is coordinately induced by maltose and repressed by glucose and this regulation is mediated by the MAL activator. By deletion analysis of the MAL61-MAL62 intergenic region, we show that a 68-basepair region, from base pairs -515 to -582 upstream of the MAL61 start codon, contains a sequence necessary for the maltose-induced expression of MAL61 and MAL62, the UAS(MAL). This sequence contains two copies of an 11-basepair dyad which may be the active elements of the UAS(MAL). Using heterologous gene plasmid constructs, we demonstrate that the UAS(MAL) sequence is sufficient for maltose inducibility of MAL62 and that this regulated expression requires a functional MAL activator. Our results suggest that the MAL61-MAL62 intergenic region contains additional distinct elements which function to precisely regulate MAL61 and/or MAL62 expression. Among these are repressing sequences, including a glucose-responsive element located between base pairs -583 and -638, which is partially responsible for mediating glucose-repression of MAL62 expression. PMID:1525871

  7. Self-association of the Escherichia coli transcription activator MalT in the presence of maltotriose and ATP.

    PubMed

    Schreiber, V; Richet, E

    1999-11-19

    MalT, the transcriptional activator of the Escherichia coli maltose regulon, binds the MalT-dependent promoters and activates transcription initiation only in the presence of maltotriose and ATP (or adenylyl imidodiphosphate (AMP-PNP)). Cooperative binding of MalT to the array of cognate sites present in the MalT-dependent promoters suggests that promoter binding involves MalT oligomerization. Gel filtration and sedimentation experiments were used to analyze the quaternary structure of MalT in solution in the absence or presence of maltotriose and/or AMP-PNP, ATP, or ADP. The protein is monomeric in the absence of ligands and in the presence of ADP. In the presence of maltotriose, AMP-PNP, or ATP only, the protein self-associates, but a large fraction of the protein remains monomeric. In the presence of both maltotriose and AMP-PNP (ATP or ADP), the protein is essentially oligomeric, with the difference being that the oligomerization is less favored in the presence of ADP + maltotriose than in the presence of AMP-PNP + maltotriose. We present evidence that the association pathway comprises the following steps: monomers --> dimers --> (MalT)(n) --> aggregates, where 3 MalT, and hence its cooperative binding to the mal promoters. PMID:10559195

  8. MalT, the regulatory protein of the Escherichia coli maltose system, is an ATP-dependent transcriptional activator.

    PubMed

    Richet, E; Raibaud, O

    1989-03-01

    We show that MalT, the transcriptional activator of the Escherichia coli maltose regulon, specifically binds ATP and dATP with a high affinity (Kd = 0.4 microM) and exhibits a weak ATPase activity. Using an abortive initiation assay, we further show that activation of open complex formation by MalT depends on the presence of ATP in addition to that of maltotriose, the inducer of the maltose system. Similar experiments in which ATP was replaced by ADP or AMP-PNP, a non-hydrolysable analogue of ATP, demonstrate that this reaction does not require ATP hydrolysis. As revealed by DNase I footprinting, both ATP and maltotriose are required for the binding of the MalT protein to the mal promoter DNA. PMID:2524384

  9. Regulation of Yersinia enterocolitica mal genes by MalT and Mlc proteins.

    PubMed

    Raczkowska, Adrianna; Brzóstkowska, Marta; Brzostek, Katarzyna

    2008-01-01

    To show the role of MalT protein in the regulation of mal genes, encoding proteins involved in transport and metabolism of maltose/ maltodextrins in Yersinia enterocolitica, we constructed a malT mutant which was characterized by a strong reduction in maltose transport and a loss of MBP protein. We also studied the influence of MalT activity on the production of Yop proteins in Y. enterocolitica and found that the level of these virulence factors is not changed in the malT mutant. Subsequently, transcriptional fusion malT::lacZYA was applied to study the activity of malT promoter. Monitoring of beta-galactosidase activity suggests the influence of catabolic repression on malT transcription, sincethe activity of malT promoter was decreased twofold in the presence of glucose. Furthermore, Mlc protein was identified in Y. enterocolitica as a factor regulating the transcription of malT. We observed a two-fold increase in the level of malT transcription in the mlc mutant background. Moreover, overproduction of Mlc protein strongly inhibited the activity of malT promoter. Thus, the data presented in this study suggest that the level of mal gene expression in Y. enterocolitica may be regulated by two proteins: MalT, the activator of mal transcription and Mlc, the repressor of malT expression. PMID:18610652

  10. Console Log Keeping Made Easier - Tools and Techniques for Improving Quality of Flight Controller Activity Logs

    NASA Technical Reports Server (NTRS)

    Scott, David W.; Underwood, Debrah (Technical Monitor)

    2002-01-01

    At the Marshall Space Flight Center's (MSFC) Payload Operations Integration Center (POIC) for International Space Station (ISS), each flight controller maintains detailed logs of activities and communications at their console position. These logs are critical for accurately controlling flight in real-time as well as providing a historical record and troubleshooting tool. This paper describes logging methods and electronic formats used at the POIC and provides food for thought on their strengths and limitations, plus proposes some innovative extensions. It also describes an inexpensive PC-based scheme for capturing and/or transcribing audio clips from communications consoles. Flight control activity (e.g. interpreting computer displays, entering data/issuing electronic commands, and communicating with others) can become extremely intense. It's essential to document it well, but the effort to do so may conflict with actual activity. This can be more than just annoying, as what's in the logs (or just as importantly not in them) often feeds back directly into the quality of future operations, whether short-term or long-term. In earlier programs, such as Spacelab, log keeping was done on paper, often using position-specific shorthand, and the other reader was at the mercy of the writer's penmanship. Today, user-friendly software solves the legibility problem and can automate date/time entry, but some content may take longer to finish due to individual typing speed and less use of symbols. File layout can be used to great advantage in making types of information easy to find, and creating searchable master logs for a given position is very easy and a real lifesaver in reconstructing events or researching a given topic. We'll examine log formats from several console position, and the types of information that are included and (just as importantly) excluded. We'll also look at when a summary or synopsis is effective, and when extensive detail is needed.

  11. Regulation of the malic enzyme gene malE by the transcriptional regulator MalR in Corynebacterium glutamicum.

    PubMed

    Krause, Jens P; Polen, Tino; Youn, Jung-Won; Emer, Denise; Eikmanns, Bernhard J; Wendisch, Volker F

    2012-06-15

    Corynebacterium glutamicum is a Gram-positive nonpathogenic bacterium that is used for the biotechnological production of amino acids. Here, we investigated the transcriptional control of the malE gene encoding malic enzyme (MalE) in C. glutamicum ATCC 13032, which is known to involve the nitrogen regulator AmtR. Gel shift experiments using purified regulators RamA and RamB revealed binding of these regulators to the malE promoter. In DNA-affinity purification experiments a hitherto uncharacterized transcriptional regulator belonging to the MarR family was found to bind to malE promoter DNA and was designated as MalR. C. glutamicum cells overexpressing malR showed reduced MalE activities in LB medium or in minimal media with acetate, glucose, pyruvate or citrate. Deletion of malR positively affected MalE activities during growth in LB medium and minimal media with pyruvate, glucose or the TCA cycle dicarboxylates l-malate, succinate and fumarate. Transcriptional fusion analysis revealed elevated malE promoter activity in the malR deletion mutant during growth in pyruvate minimal medium suggesting that MalR acts as a repressor of malE. Purified MalR bound malE promoter DNA in gel shift experiments. Two MalR binding sites were identified in the malE promoter by mutational analysis. Thus, MalR contributes to the complex transcriptional control of malE which also involves RamA, RamB and AmtR. PMID:22261175

  12. [Clonage of the "malA" region of "Escherichia coli" K12: nucleotide sequence of the regulatory region and the promoters, identification and purification of the MalT-activator protein (author's transl)].

    PubMed

    Raibaud, O; Débarbouillé, M; Cossart, P

    1982-01-01

    A 5,800-bp (base pair) HindIII-EcoRI DNA fragment containing malT, the positive regulator gene of the maltose regulon, and most of malP, the structural gene for maltodextrin phosphorylase, was cloned into pBR322. A sequence of 802 bp was established in a DNA segment containing the promotor for malPQ and the promoter for malT. A total of 611 bp separates the initiation codons for these two genes, which are transcribed in opposite directions. The malT product was identified as a 94,000 dalton polypeptide. PMID:6462088

  13. The Myelin and Lymphocyte Protein MAL Is Required for Binding and Activity of Clostridium perfringens ε-Toxin

    PubMed Central

    Oo, Myat Lin; Anrather, Josef; Schaeren-Wiemers, Nicole; Alonso, Miguel A.; Fischetti, Vincent A.; McClain, Mark S.; Vartanian, Timothy

    2015-01-01

    Clostridium perfringens ε-toxin (ETX) is a potent pore-forming toxin responsible for a central nervous system (CNS) disease in ruminant animals with characteristics of blood-brain barrier (BBB) dysfunction and white matter injury. ETX has been proposed as a potential causative agent for Multiple Sclerosis (MS), a human disease that begins with BBB breakdown and injury to myelin forming cells of the CNS. The receptor for ETX is unknown. Here we show that both binding of ETX to mammalian cells and cytotoxicity requires the tetraspan proteolipid Myelin and Lymphocyte protein (MAL). While native Chinese Hamster Ovary (CHO) cells are resistant to ETX, exogenous expression of MAL in CHO cells confers both ETX binding and susceptibility to ETX-mediated cell death. Cells expressing rat MAL are ~100 times more sensitive to ETX than cells expressing similar levels of human MAL. Insertion of the FLAG sequence into the second extracellular loop of MAL abolishes ETX binding and cytotoxicity. ETX is known to bind specifically and with high affinity to intestinal epithelium, renal tubules, brain endothelial cells and myelin. We identify specific binding of ETX to these structures and additionally show binding to retinal microvasculature and the squamous epithelial cells of the sclera in wild-type mice. In contrast, there is a complete absence of ETX binding to tissues from MAL knockout (MAL-/-) mice. Furthermore, MAL-/- mice exhibit complete resistance to ETX at doses in excess of 1000 times the symptomatic dose for wild-type mice. We conclude that MAL is required for both ETX binding and cytotoxicity. PMID:25993478

  14. Data for Free: Using LMS Activity Logs to Measure Community in Online Courses

    ERIC Educational Resources Information Center

    Black, Erik W.; Dawson, Kara; Priem, Jason

    2008-01-01

    In the study of online learning community, many investigators have turned attention to automatically logged web data. This study aims to further this work by seeking to determine whether logs of student activity within online graduate level courses related to student perceptions of course community. Researchers utilized the data logging features…

  15. PARduino: A Simple Device Measuring and Logging Photosynthetically Active Radiation

    NASA Astrophysics Data System (ADS)

    Barnard, H. R.; Findley, M. C.

    2013-12-01

    Photosynthetically Active Radiation (PAR, 400 to 700 nm) is one of the primary controls of forest carbon and water relations. In complex terrain, PAR has high spatial-variability. Given the high cost of commercial datalogging equipment, spatially-distributed measurements of PAR have been typically modeled using geographic coordinates and terrain indices. Here, we present a design for a low cost, field-deployable device for measuring and logging PAR built around an Arduino microcontroller (we named it PARduino). PARduino provides for widely distributed sensor arrays and tests the feasibility of using hobbyist-grade electronics for collecting scientific data. PARduino components include a LiCor quantum sensor, EME Systems signal converter/amplifier, and Sparkfun's Arduino Pro Mini microcontroller. Additional components include a real time clock, a microSD flash memory card, and a custom printed circuit board (PCB). We selected the components with an eye towards ease of assembly. Everything can be connected to the PCB using through-hole soldering techniques. Since the device will be deployed in remote research plots that lack easy access to line power, battery life was also a consideration in the design. Extended deployment is possible because PARduino's software keeps it in a low-power sleep mode until ready to make a measurement. PARduino will be open-source hardware for use and improvement by others.

  16. Negative transcriptional regulation of a positive regulator: the expression of malT, encoding the transcriptional activator of the maltose regulon of Escherichia coli, is negatively controlled by Mlc.

    PubMed

    Decker, K; Plumbridge, J; Boos, W

    1998-01-01

    The maltose regulon consists of 10 genes encoding a multicomponent and binding protein-dependent ABC transporter for maltose and maltodextrins as well as enzymes necessary for the degradation of these sugars. MalT, the transcriptional activator of the system, is necessary for the transcription of all mal genes. MalK, the energy-transducing subunit of the transport system, acts phenotypically as repressor, particularly when overproduced. We isolated an insertion mutation that strongly reduced the repressing effect of overproduced MalK. The affected gene was sequenced and identified as mlc, a known gene encoding a protein of unknown function with homology to the Escherichia coli NagC protein. The loss of Mlc function led to a threefold increase in malT expression, and the presence of mlc on a multicopy plasmid reduced malT expression. By DNasel protection assay, we found that Mlc protected a DNA region comprising positions +1 to +23 of the malT transcriptional start point. Using a mlc-lacZ fusion in a mlc and mlc+ background, we found that Mlc represses its own expression. As Mlc also regulates another operon (manXYZ, see pages 369-379 of this issue), it may very well constitute a new global regulator of carbohydrate utilization. PMID:9484893

  17. Effects of Adjuvant Mental Practice on Affected Upper Limb Function Following a Stroke: Results of Three-Dimensional Motion Analysis, Fugl-Meyer Assessment of the Upper Extremity and Motor Activity Logs

    PubMed Central

    2016-01-01

    Objective To investigate the effects of adjuvant mental practice (MP) on affected upper limb function following a stroke using three-dimensional (3D) motion analysis. Methods In this AB/BA crossover study, we studied 10 hemiplegic patients who had a stroke within the past 6 months. The patients were randomly allocated to two groups: one group received MP combined with conventional rehabilitation therapy for the first 3 weeks followed by conventional rehabilitation therapy alone for the final 3 weeks; the other group received the same therapy but in reverse order. The MP tasks included drinking from a cup and opening a door. MP was individually administered for 20 minutes, 3 days a week for 3 weeks. To assess the tasks, we used 3D motion analysis and three additional tests: the Fugl-Meyer Assessment of the upper extremity (FMA-UE) and the motor activity logs for amount of use (MAL-AOU) and quality of movement (MAL-QOM). Assessments were performed immediately before treatment (T0), 3 weeks into treatment (T1), and 6 weeks into treatment (T2). Results Based on the results of the 3D motion analysis and the FMA-UE index (p=0.106), the MAL-AOU scale (p=0.092), and MAL-QOM scale (p=0.273), adjuvant MP did not result in significant improvements. Conclusion Adjuvant MP had no significant effect on upper limb function following a stroke, according to 3D motion analysis and three clinical assessment tools (the FMA-UE index and the two MAL scales). The importance of this study is its use of objective 3D motion analysis to evaluate the effects of MP. Further studies will be needed to validate these findings. PMID:27446776

  18. Expression and biological activity of genetic fusions between MalE, the maltose binding protein from Escherichia coli and portions of CD4, the T-cell receptor of the AIDS virus.

    PubMed

    Clément, J M; Jehanno, M; Popescu, O; Saurin, W; Hofnung, M

    1996-11-01

    Hybrid molecules between MalE, the periplasmic maltose binding protein of Escherichia coli, and CD4, the human T-lymphocyte receptor for the AIDS virus HIV, have been constructed and purified. We show that CD4 can be fused as multiple repeats to both ends of a single MalE molecule. Hybrid proteins are exported into the periplasm of bacteria, bind monoclonal antibodies directed against CD4, bind HIV gp160, and inhibit HIV binding to CD4+ cells. MalE has been used as a scaffold to graft portions of CD4. Deletion analysis allowed to define a minimal structural domain which folds in a way which is compatible with its biological activity. This minimal part was used to design compact hybrid molecules in which CD4 was inserted internally into MalE. PMID:8936594

  19. Characterization and expression analysis of a maltose-utilizing (MAL) cluster in Aspergillus oryzae.

    PubMed

    Hasegawa, Sachiko; Takizawa, Masahiro; Suyama, Haruhiko; Shintani, Takahiro; Gomi, Katsuya

    2010-01-01

    Starch and maltooligosaccharides such as maltose and maltotriose induce the production of amylolytic enzymes including alpha-amylase in Aspergillus oryzae. A transcriptional activator gene amyR, required for maltose induction of amylolytic enzymes, has been cloned and characterized. The amyR gene deletion mutant showed significantly poor growth on starch medium but normal growth on maltose medium. This indicated the existence of another maltose-utilizing system, whose expression might not be controlled by amyR. We have identified a gene cluster homologous to the MAL cluster of Saccharomyces cerevisiae in the A. oryzae genome. The cluster consists of a MAL61 homolog (designated malP), a MAL62 homolog (designated malT), and a MAL63 homolog (designated malR). Overexpression of malT in A. oryzae resulted in a significant increase in intracellular alpha-glucosidase activity, and that of malP allowed S. cerevisiaemal61Delta to grow on maltose. The expression of both malP and malT genes was highly up-regulated in the presence of maltose, but malR expressed constitutively irrespective of carbon sources. Disruption of malR resulted in the loss of malP and malT expression and thus in restricted growth on maltose medium. In addition, a malP disruptant showed a significantly reduced expression of malT and malR and exhibited a growth defect on maltose similar to the malR disruptant. These results suggest that the MAL cluster of A. oryzae is responsible for the assimilation of maltose in A. oryzae. PMID:19850146

  20. Activity of protein MalE (maltose-binding protein) fused to cytoplasmic and periplasmic regions of an Escherichia coli inner membrane protein.

    PubMed

    Dassa, E; Lambert, P

    1997-06-01

    We analysed the properties of mature MBP (maltose-binding protein or MalE protein) fused to an integral cytoplasmic membrane protein of Escherichia coli. Fusion of MalE to the first MalG periplasmic loop enabled a strain defective in the malE gene to utilize maltose. In contrast, fusion of MalE to a cytoplasmic loop did not complement the malE delta 444 deletion. We obtained results highly correlated with those obtained by using alkaline phosphatase as a reporter for the topology of MalG. We discuss the possibility of genetically determining the topology of cytoplasmic membrane proteins by a method based on engineered fusions to MBP. PMID:9765817

  1. Allele-specific malE mutations that restore interactions between maltose-binding protein and the inner-membrane components of the maltose transport system.

    PubMed

    Treptow, N A; Shuman, H A

    1988-08-20

    Active accumulation of maltose and maltodextrins by Escherichia coli depends on an outer-membrane protein. LamB, a periplasmic maltose-binding protein (MalE, MBP) and three inner-membrane proteins, MalF, MalG and MalK. MalF and MalG are integral transmembrane proteins, while MalK is associated with the inner aspect of the cytoplasmic membrane via an interaction with MalG. Previously we have shown that MBP is essential for movement of maltose across the inner membrane. We have taken advantage of malF and malG mutants in which MBP interacts improperly with the membrane proteins. We describe the properties of malE mutations in which a proper interaction between MBP and defective MalF and MalG proteins has been restored. We found that these malE suppressor mutations are able to restore transport activity in an allele-specific manner. That is, a given malE mutation restores transport activity to different extents in different malF and malG mutants. Since both malF and malG mutations could be suppressed by allele-specific malE suppressors, we propose that, in wild-type bacteria, MBP interacts with sites on both MalF and MalG during active transport. The locations of different malE suppressor mutations indicate specific regions on MBP that are important for interacting with MalF and MalG. PMID:3050132

  2. How ‘arm-twisting’ by the inducer triggers activation of the MalT transcription factor, a typical signal transduction ATPase with numerous domains (STAND)

    PubMed Central

    Danot, Olivier

    2015-01-01

    Signal transduction ATPases with numerous domains (STAND) get activated through inducer-dependent assembly into multimeric platforms. This switch relies on the conversion of their nucleotide-binding oligomerization domain (NOD) from a closed, ADP-bound form to an open, ATP-bound form. The NOD closed form is stabilized by contacts with the arm, a domain that connects the NOD to the inducer-binding domain called the sensor. How the inducer triggers NOD opening remains unclear. Here, I pinpointed the NOD-arm interface of the MalT STAND transcription factor, and I generated a MalT variant in which this interface can be covalently locked on demand, thereby trapping the NOD in the closed state. By characterizing this locked variant, I found that the inducer is recognized in two steps: it first binds to the sole sensor with low affinity, which then triggers the recruitment of the arm to form a high-affinity arm-sensor inducer-binding site. Strikingly, this high-affinity binding step was incompatible with arm-NOD contacts maintaining the NOD closed. Through this toggling between two mutually exclusive states reminiscent of a single-pole double-throw switch, the arm couples inducer binding to NOD opening, shown here to precede nucleotide exchange. This scenario likely holds for other STANDs like mammalian NLR innate immunity receptors. PMID:25740650

  3. Revealing Student Blogging Activities Using RSS Feeds and LMS Logs

    ERIC Educational Resources Information Center

    Derntl, Michael

    2010-01-01

    Blogs are an easy-to-use, free alternative to classic means of computer-mediated communication. Moreover, they are authentically aligned with web activity patterns of today's students. The body of studies on integrating and implementing blogs in various educational settings has grown rapidly recently; however, it is often difficult to distill…

  4. Glucose- and glucokinase-controlled mal gene expression in Escherichia coli.

    PubMed

    Lengsfeld, Christina; Schönert, Stefan; Dippel, Renate; Boos, Winfried

    2009-02-01

    MalT is the central transcriptional activator of all mal genes in Escherichia coli. Its activity is controlled by the inducer maltotriose. It can be inhibited by the interaction with certain proteins, and its expression can be controlled. We report here a novel aspect of mal gene regulation: the effect of cytoplasmic glucose and glucokinase (Glk) on the activity and the expression of MalT. Amylomaltase (MalQ) is essential for the metabolism of maltose. It forms maltodextrins and glucose from maltose or maltodextrins. We found that glucose above a concentration of 0.1 mM blocked the activity of the enzyme. malQ mutants when grown in the absence of maltodextrins are endogenously induced by maltotriose that is derived from the degradation of glycogen. Therefore, the fact that glk malQ(+) mutants showed elevated mal gene expression finds its explanation in the reduced ability to remove glucose from MalQ-catalyzed maltodextrin formation and is caused by a metabolically induced MalQ(-) phenotype. However, even in mutants lacking glycogen, Glk controls endogenous induction. We found that overexpressed Glk due to its structural similarity with Mlc, the repressor of malT, binds to the glucose transporter (PtsG), releasing Mlc and thus increasing malT repression. In addition, even in mutants lacking Mlc (and glycogen), the overexpression of glk leads to a reduction in mal gene expression. We interpret this repression by a direct interaction of Glk with MalT concomitant with MalT inhibition. This repression was dependent on the presence of either maltodextrin phosphorylase or amylomaltase and led to the inactivation of MalT. PMID:19028900

  5. Mutations in tar suppress defects in maltose chemotaxis caused by specific malE mutations.

    PubMed

    Manson, M D; Kossmann, M

    1986-01-01

    Maltose-binding protein (MBP), which is encoded by the malE gene, is the maltose chemoreceptor of Escherichia coli, as well as an essential component of the maltose uptake system. Maltose-loaded MBP is thought to initiate a chemotactic response by binding to the tar gene product, the signal transducer Tar, which is also the aspartate chemoreceptor. To study the interaction of MBP with Tar, we selected 14 malE mutants which had specific defects in maltose taxis. Three of these mutants were fully active in maltose transport and produced MBP in normal amounts. The isoelectric points of the MBPs from these three mutants were identical to (malE461 and malE469) or only 0.1 pH unit more basic than (malE454) the isoelectric point of the wild-type protein (pH 5.0). Six of the mutations, including malE454, malE461, and malE469, were mapped in detail; they were located in two regions within malE. We also isolated second-site suppressor mutations in the tar gene that restored maltose taxis in combination with the closely linked malE454 and malE461 mutations but not with the malE469 mutation, which maps in a different part of the gene. This allele-specific suppression confirmed that MBP and Tar interact directly. PMID:3510191

  6. Induction conductivity and natural gamma logs collected in 15 wells at Camp Stanley Storage Activity, Bexar County, Texas

    USGS Publications Warehouse

    Stanton, Gregory P.

    2005-01-01

    The U.S. Geological Survey, in cooperation with the Camp Stanley Storage Activity conducted electromagnetic induction conductivity and natural gamma logging of 15 selected wells on the Camp Stanley Storage Activity, located in northern Bexar County, Texas, during March 28-30, 2005. In late 2004, a helicopter electromagnetic survey was flown of the Camp Stanley Storage Activity as part of a U.S. Geological Survey project to better define subsurface geologic units, the structure, and the catchment area of the Trinity aquifer. The electromagnetic induction conductivity and natural gamma log data in this report were collected to constrain the calculation of resistivity depth sections and to provide subsurface controls for interpretation of the helicopter electromagnetic data collected for the Camp Stanley Storage Activity. Logs were recorded digitally while moving the probe in an upward direction to maintain proper depth control. Logging speed was no greater than 30 feet per minute. During logging, a repeat section of at least 100 feet was recorded to check repeatability of log responses. Several of the wells logged were completed with polyvinyl chloride casing that can be penetrated by electromagnetic induction fields and allows conductivity measurement. However, some wells were constructed with steel centralizers and stainless steel screen that caused spikes on both conductivity and resulting resistivity log curves. These responses are easily recognizable and appear at regular intervals on several logs.

  7. Investigation of the malE Promoter and MalR, a Positive Regulator of the Maltose Regulon, for an Improved Expression System in Sulfolobus acidocaldarius

    PubMed Central

    Wagner, Michaela; Wagner, Alexander; Ma, Xiaoqing; Kort, Julia Christin; Ghosh, Abhrajyoti; Rauch, Bernadette; Siebers, Bettina

    2014-01-01

    In this study, the regulator MalR (Saci_1161) of the TrmB family from Sulfolobus acidocaldarius was identified and was shown to be involved in transcriptional control of the maltose regulon (Saci_1660 to Saci_1666), including the ABC transporter (malEFGK), α-amylase (amyA), and α-glycosidase (malA). The ΔmalR deletion mutant exhibited a significantly decreased growth rate on maltose and dextrin but not on sucrose. The expression of the genes organized in the maltose regulon was induced only in the presence of MalR and maltose in the growth medium, indicating that MalR, in contrast to its TrmB and TrmB-like homologues, is an activator of the maltose gene cluster. Electrophoretic mobility shift assays revealed that the binding of MalR to malE was independent of sugars. Here we report the identification of the archaeal maltose regulator protein MalR, which acts as an activator and controls the expression of genes involved in maltose transport and metabolic conversion in S. acidocaldarius, and its use for improvement of the S. acidocaldarius expression system under the control of an optimized maltose binding protein (malE) promoter by promoter mutagenesis. PMID:24271181

  8. Mutations in SIN4 and RGR1 cause constitutive expression of MAL structural genes in Saccharomyces cerevisiae.

    PubMed

    Wang, Xin; Michels, Corinne A

    2004-10-01

    Transcription of the Saccharomyces MAL structural genes is induced 40-fold by maltose and requires the MAL-activator and maltose permease. To identify additional players involved in regulating MAL gene expression, we carried out a genetic selection for MAL constitutive mutants. Strain CMY4000 containing MAL1 and integrated copies of MAL61promoter-HIS3 and MAL61promoter-lacZ reporter genes was used to select constitutive mutants. The 29 recessive mutants fall into at least three complementation groups. Group 1 and group 2 mutants exhibit pleiotropic phenotypes and represent alleles of Mediator component genes RGR1 and SIN4, respectively. The rgr1 and sin4 constitutive phenotype does not require either the MAL-activator or maltose permease, indicating that Mediator represses MAL basal expression. Further genetic analysis demonstrates that RGR1 and SIN4 work in a common pathway and each component of the Mediator Sin4 module plays a distinct role in regulating MAL gene expression. Additionally, the Swi/Snf chromatin-remodeling complex is required for full induction, suggesting a role for chromatin remodeling in the regulation of MAL gene expression. A sin4Delta mutation is unable to suppress the defects in MAL gene expression resulting from loss of the Swi/Snf complex component Snf2p. The role of the Mediator in MAL gene regulation is discussed. PMID:15514050

  9. The MalT-dependent and malZ-encoded maltodextrin glucosidase of Escherichia coli can be converted into a dextrinyltransferase by a single mutation.

    PubMed

    Peist, R; Schneider-Fresenius, C; Boos, W

    1996-05-01

    malZ is a member of the mal regulon. It is controlled by MatT, the transcriptional activator of the maltose system. MalZ has been purified and identified as an enzyme hydrolyzing maltotriose and longer maltodextrins to glucose and maltose. MalZ is dispensable for growth on maltose or maltodextrins. Mutants lacking amylomaltase (encoded by malQ), the major maltose utilizing enzyme, cannot grow on maltose, maltotriose, or maltotetraose, despite the fact that they contain an effective transport system and MalZ. From such a malQ mutant a pseudorevertant was isolated that was able to grow on maltose. The suppressor mutation was mapped in malZ. The mutant gene was cloned. It contained a Trp to Cys exchange at position 292 of the deduced protein sequence. Surprisingly, the purified mutant enzyme was still unable to hydrolyze maltose as was the wild type enzyme, while both were able to release glucose from maltodextrins. However, the mutant enzyme had gained the ability to transfer dextrinyl moieties to glucose, maltose, and other maltodextrins. Thus, it had gained an activity associated with amylomaltase. It was the MalZ292-associated transferase reaction that allowed the utilization of maltose. In addition, we discovered that mutant and wild type enzyme alike were highly active as gamma-cyclodextrinases. PMID:8631875

  10. Correlation of fungostatic activity with log P and sigma parameters in the group of thiobenzanilides.

    PubMed

    Jóźwiak, K; Szumiło, H

    2000-11-01

    2,4-Dihydroxythiobenzanilide and its analogues were recently found to show strong biological activity. Earlier works exhibited that their biological activity depends strongly on their lipophilicity determined by means of RP-HPLC. Among others, fungostatic activity against tested yeast and mould strains appeared to be comparatively poorer modelled by chromatographic lipophilicity parameters. Very high correlation (r approximately 0.85-0.9) with these activities was obtained by means of multiparameter regression analysis where calculated log P and Hammet sigma values were involved as the independent variables. Analysed data show that activity against yeast and mould fungi is a superposition of two basic properties of thiobenzanilides: their lipophilicity and electronic properties. PMID:11293275

  11. Sensing actin dynamics: Structural basis for G-actin-sensitive nuclear import of MAL

    SciTech Connect

    Hirano, Hidemi; Matsuura, Yoshiyuki

    2011-10-22

    Highlights: {yields} MAL has a bipartite NLS that binds to Imp{alpha} in an extended conformation. {yields} Mutational analyses verified the functional significance of MAL-Imp{alpha} interactions. {yields} Induced folding and NLS-masking by G-actins inhibit nuclear import of MAL. -- Abstract: The coordination of cytoskeletal actin dynamics with gene expression reprogramming is emerging as a crucial mechanism to control diverse cellular processes, including cell migration, differentiation and neuronal circuit assembly. The actin-binding transcriptional coactivator MAL (also known as MRTF-A/MKL1/BSAC) senses G-actin concentration and transduces Rho GTPase signals to serum response factor (SRF). MAL rapidly shuttles between the cytoplasm and the nucleus in unstimulated cells but Rho-induced depletion of G-actin leads to MAL nuclear accumulation and activation of transcription of SRF:MAL-target genes. Although the molecular and structural basis of actin-regulated nucleocytoplasmic shuttling of MAL is not understood fully, it is proposed that nuclear import of MAL is mediated by importin {alpha}/{beta} heterodimer, and that G-actin competes with importin {alpha}/{beta} for the binding to MAL. Here we present structural, biochemical and cell biological evidence that MAL has a classical bipartite nuclear localization signal (NLS) in the N-terminal 'RPEL' domain containing Arg-Pro-X-X-X-Glu-Leu (RPEL) motifs. The NLS residues of MAL adopt an extended conformation and bind along the surface groove of importin-{alpha}, interacting with the major- and minor-NLS binding sites. We also present a crystal structure of wild-type MAL RPEL domain in complex with five G-actins. Comparison of the importin-{alpha}- and actin-complexes revealed that the binding of G-actins to MAL is associated with folding of NLS residues into a helical conformation that is inappropriate for importin-{alpha} recognition.

  12. Gly-46 and His-50 of yeast maltose transporter Mal21p are essential for its resistance against glucose-induced degradation.

    PubMed

    Hatanaka, Haruyo; Omura, Fumihiko; Kodama, Yukiko; Ashikari, Toshihiko

    2009-06-01

    The maltose transporter gene is situated at the MAL locus, which consists of genes for a transporter, maltase, and transcriptional activator. Five unlinked MAL loci (MAL1, MAL2, MAL3, MAL4, and MAL6) constitute a gene family in Saccharomyces cerevisiae. The expression of the maltose transporter is induced by maltose and repressed by glucose. The activity of the maltose transporter is also regulated post-translationally; Mal61p is rapidly internalized from the plasma membrane and degraded by ubiquitin-mediated proteolysis in the presence of glucose. We found that S. cerevisiae strain ATCC20598 harboring MAL21 could grow in maltose supplemented with a non- assimilable glucose analogue, 2-deoxyglucose, whereas strain ATCC96955 harboring MAL61 and strain CB11 with MAL31 and AGT1 could not. These observations implied a Mal21p-specific resistance against glucose-induced degradation. Mal21p found in ATCC20598 has 10 amino acids, including Gly-46 and His-50, that are inconsistent with the corresponding residues in Mal61p. The half-life of Mal21p for glucose-induced degradation was 118 min when expressed using the constitutive TPI1 promoter, which was significantly longer than that of Mal61p (25 min). Studies with mutant cells that are defective in endocytosis or the ubiquitination process indicated that Mal21p was less ubiquitinated than Mal61p, suggesting that Mal21p remains on the plasma membrane because of poor susceptibility to ubiquitination. Mutational studies revealed that both residues Gly-46 and His-50 in Mal21p are essential for the full resistance of maltose transporters against glucose-induced degradation. PMID:19359240

  13. Gly-46 and His-50 of Yeast Maltose Transporter Mal21p Are Essential for Its Resistance against Glucose-induced Degradation

    PubMed Central

    Hatanaka, Haruyo; Omura, Fumihiko; Kodama, Yukiko; Ashikari, Toshihiko

    2009-01-01

    The maltose transporter gene is situated at the MAL locus, which consists of genes for a transporter, maltase, and transcriptional activator. Five unlinked MAL loci (MAL1, MAL2, MAL3, MAL4, and MAL6) constitute a gene family in Saccharomyces cerevisiae. The expression of the maltose transporter is induced by maltose and repressed by glucose. The activity of the maltose transporter is also regulated post-translationally; Mal61p is rapidly internalized from the plasma membrane and degraded by ubiquitin-mediated proteolysis in the presence of glucose. We found that S. cerevisiae strain ATCC20598 harboring MAL21 could grow in maltose supplemented with a non- assimilable glucose analogue, 2-deoxyglucose, whereas strain ATCC96955 harboring MAL61 and strain CB11 with MAL31 and AGT1 could not. These observations implied a Mal21p-specific resistance against glucose-induced degradation. Mal21p found in ATCC20598 has 10 amino acids, including Gly-46 and His-50, that are inconsistent with the corresponding residues in Mal61p. The half-life of Mal21p for glucose-induced degradation was 118 min when expressed using the constitutive TPI1 promoter, which was significantly longer than that of Mal61p (25 min). Studies with mutant cells that are defective in endocytosis or the ubiquitination process indicated that Mal21p was less ubiquitinated than Mal61p, suggesting that Mal21p remains on the plasma membrane because of poor susceptibility to ubiquitination. Mutational studies revealed that both residues Gly-46 and His-50 in Mal21p are essential for the full resistance of maltose transporters against glucose-induced degradation. PMID:19359240

  14. MIG1-dependent and MIG1-independent glucose regulation of MAL gene expression in Saccharomyces cerevisiae.

    PubMed

    Hu, Z; Nehlin, J O; Ronne, H; Michels, C A

    1995-08-01

    Glucose repression is a global regulatory system in Saccharomyces cerevisiae controlling carbon-source utilization, mitochondrial biogenesis, gluconeogenesis and other metabolic pathways. Mig1p, a zinc-finger class of DNA-binding protein, is a transcriptional repressor regulating GAL and SUC gene expression in response to glucose. This report demonstrates that Mig1 protein represses transcription of the MAL61 and MAL62 structural genes and also the MAL63 gene, which encodes the Mal-activator. Mig1p DNA-binding sites were identified upstream of all three MAL genes. Both of the Mig1p-binding sites found in the bidirectional MAL61-MAL62 promoter were shown to function in the Mig1p-dependent glucose repression. Studies using constitutive Mal-activator alleles suggest that glucose regulation of inducer availability is a second major contributing factor in glucose repression of MAL gene expression and is even stronger than the Mig1p-dependent component of repression. Moreover, our results also suggest the contribution of other minor mechanisms in glucose regulation of MAL gene expression. PMID:8529272

  15. Genetic variation of the repeated MAL loci in natural populations of Saccharomyces cerevisiae and Saccharomyces paradoxus.

    PubMed

    Naumov, G I; Naumova, E S; Michels, C A

    1994-03-01

    In Saccharomyces cerevisiae, the gene functions required to ferment the disaccharide maltose are encoded by the MAL loci. Any one of five highly sequence homologous MAL loci identified in various S. cerevisiae strains (called MAL1, 2, 3, 4 and 6) is sufficient to ferment maltose. Each is a complex of three genes encoding maltose permease, maltase and a transcription activator. This family of loci maps to telomere-linked positions on different chromosomes and most natural strains contain more than one MAL locus. A number of naturally occurring, mutant alleles of MAL1 and MAL3 have been characterized which lack one or more of the gene functions encoded by the fully functional MAL loci. Loss of these gene functions appears to have resulted from mutation and/or rearrangement within the locus. Studies to date concentrated on the standard maltose fermenting strains of S. cerevisiae available from the Berkeley Yeast Stock Center collection. In this report we extend our genetic analysis of the MAL loci to a number of maltose fermenting and nonfermenting natural strains of S. cerevisiae and Saccharomyces paradoxus. No new MAL loci were discovered but several new mutant alleles of MAL1 were identified. The evolution of this gene family is discussed. PMID:8005435

  16. Mal de Meleda: A Focused Review.

    PubMed

    Perez, Caroline; Khachemoune, Amor

    2016-02-01

    Mal de Meleda is a rare autosomal recessive palmoplantar keratoderma (PPK) disease with an estimated prevalence of 1:100,000. Clinically, the onset of the disease is typically soon after birth and features a transgrediens (plantar surface progressing to dorsal surface) and progrediens (worsening with age) pattern of hyperkeratosis of the palms and soles. The disease can feature other potentially disfiguring effects on the hands and feet that can severely impact function. Histologically, the lesions show hyperkeratosis and acanthosis without epidermolysis in the epidermis, accompanied by perivascular lymphocytic infiltrate in the dermis. Secreted LY6/urokinase-type plasminogen activator receptor (uPAR)-related protein-1 (SLURP-1) genetic mutations are implicated in Mal de Meleda. SLURP-1 is involved in mediation of inflammation as well as keratinocyte apoptosis regulation. Because the disease is so rare, there are no set guidelines for management, but the accepted approach tends to include oral acitretin plus topical keratolytic therapy. Genetic counseling should also be offered. This focused review highlights the clinical and histological features, differential diagnoses, genetic background, and the current thoughts on management of Mal de Meleda. PMID:26445964

  17. A Depth Video Sensor-Based Life-Logging Human Activity Recognition System for Elderly Care in Smart Indoor Environments

    PubMed Central

    Jalal, Ahmad; Kamal, Shaharyar; Kim, Daijin

    2014-01-01

    Recent advancements in depth video sensors technologies have made human activity recognition (HAR) realizable for elderly monitoring applications. Although conventional HAR utilizes RGB video sensors, HAR could be greatly improved with depth video sensors which produce depth or distance information. In this paper, a depth-based life logging HAR system is designed to recognize the daily activities of elderly people and turn these environments into an intelligent living space. Initially, a depth imaging sensor is used to capture depth silhouettes. Based on these silhouettes, human skeletons with joint information are produced which are further used for activity recognition and generating their life logs. The life-logging system is divided into two processes. Firstly, the training system includes data collection using a depth camera, feature extraction and training for each activity via Hidden Markov Models. Secondly, after training, the recognition engine starts to recognize the learned activities and produces life logs. The system was evaluated using life logging features against principal component and independent component features and achieved satisfactory recognition rates against the conventional approaches. Experiments conducted on the smart indoor activity datasets and the MSRDailyActivity3D dataset show promising results. The proposed system is directly applicable to any elderly monitoring system, such as monitoring healthcare problems for elderly people, or examining the indoor activities of people at home, office or hospital. PMID:24991942

  18. The feasibility of well-logging measurements of arsenic levels using neutron-activation analysis

    USGS Publications Warehouse

    Oden, C.P.; Schweitzer, J.S.; McDowell, G.M.

    2006-01-01

    Arsenic is an extremely toxic metal, which poses a significant problem in many mining environments. Arsenic contamination is also a major problem in ground and surface waters. A feasibility study was conducted to determine if neutron-activation analysis is a practical method of measuring in situ arsenic levels. The response of hypothetical well-logging tools to arsenic was simulated using a readily available Monte Carlo simulation code (MCNP). Simulations were made for probes with both hyperpure germanium (HPGe) and bismuth germanate (BGO) detectors using accelerator and isotopic neutron sources. Both sources produce similar results; however, the BGO detector is much more susceptible to spectral interference than the HPGe detector. Spectral interference from copper can preclude low-level arsenic measurements when using the BGO detector. Results show that a borehole probe could be built that would measure arsenic concentrations of 100 ppm by weight to an uncertainty of 50 ppm in about 15 min. ?? 2006 Elsevier Ltd. All rights reserved.

  19. Maltose-Dependent Transcriptional Regulation of the mal Regulon by MalR in Streptococcus pneumoniae

    PubMed Central

    Afzal, Muhammad; Shafeeq, Sulman; Manzoor, Irfan; Kuipers, Oscar P.

    2015-01-01

    The maltose regulon (mal regulon) has previously been shown to consist of the mal gene cluster (malMP, malXCD and malAR operons) in Streptococcus pneumoniae. In this study, we have further elucidated the complete mal regulon in S. pneumoniae D39 using microarray analyses and β-galactosidase assays. In addition to the mal gene cluster, the complete mal regulon of S. pneumoniae D39 consists of a pullulanase (PulA), a glucosidase (DexB), a glucokinase (RokB), a PTS component (PtsG) and an amylase (AmyA2). Our microarray studies and β-galactosidase assays further showed that the LacI-family transcriptional regulator MalR represses the expression of the mal regulon in the absence of maltose. Furthermore, the role of the pleiotropic transcriptional regulator CcpA in the regulation of the mal regulon in the presence of maltose was explored. Our microarray analysis with a ΔccpA strain showed that CcpA only represses the expression of the malXCD operon and the pulA gene in the presence of maltose. Hence, we extend the mal regulon now consisting of pulA, dexB, rokB, ptsG and amyA2 in addition to malMP, malXCD and malAR operons. PMID:26030923

  20. Maltose-Dependent Transcriptional Regulation of the mal Regulon by MalR in Streptococcus pneumoniae.

    PubMed

    Afzal, Muhammad; Shafeeq, Sulman; Manzoor, Irfan; Kuipers, Oscar P

    2015-01-01

    The maltose regulon (mal regulon) has previously been shown to consist of the mal gene cluster (malMP, malXCD and malAR operons) in Streptococcus pneumoniae. In this study, we have further elucidated the complete mal regulon in S. pneumoniae D39 using microarray analyses and β-galactosidase assays. In addition to the mal gene cluster, the complete mal regulon of S. pneumoniae D39 consists of a pullulanase (PulA), a glucosidase (DexB), a glucokinase (RokB), a PTS component (PtsG) and an amylase (AmyA2). Our microarray studies and β-galactosidase assays further showed that the LacI-family transcriptional regulator MalR represses the expression of the mal regulon in the absence of maltose. Furthermore, the role of the pleiotropic transcriptional regulator CcpA in the regulation of the mal regulon in the presence of maltose was explored. Our microarray analysis with a ΔccpA strain showed that CcpA only represses the expression of the malXCD operon and the pulA gene in the presence of maltose. Hence, we extend the mal regulon now consisting of pulA, dexB, rokB, ptsG and amyA2 in addition to malMP, malXCD and malAR operons. PMID:26030923

  1. 75 FR 81660 - Agency Information Collection Activities; Submission for OMB Review; Comment Request; Logging...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-28

    ... additional information, see the related notice published in the Federal Register on October 15, 2010 (75 FR...; Logging Operations Standard ACTION: Notice. SUMMARY: The Department of Labor (DOL) hereby announces the... request (ICR) titled, ``Logging Operations Standard,'' to the Office of Management and Budget (OMB)...

  2. Identification and Characterization of MalA in the Maltose/Maltodextrin Operon of Sulfolobus acidocaldarius DSM639

    PubMed Central

    Choi, Kyoung-Hwa; Hwang, Sungmin

    2013-01-01

    A putative maltose/maltodextrin operon was found in the Sulfolobus acidocaldarius DSM639 genome. The gene cluster consisted of 7 genes (malA, trmB, amyA, malG, malF, malE, and malK). Here, we report the identification of MalA, which is responsible for the hydrolysis of maltose or maltodextrin to glucose in S. acidocaldarius. The transcription level of malA was increased 3-fold upon the addition of maltose or starch to the medium. Moreover, the α-glucosidase activity for maltose as a substrate in cell extracts of S. acidocaldarius DSM639 was also 11- and 10-fold higher during growth in YT medium (Brock's mineral salts, 0.1% [wt/vol] tryptone, and 0.005% [wt/vol] yeast extract) containing maltose or starch, respectively, than during growth on other sugars. The gene encoding MalA was cloned and expressed in S. acidocaldarius. The enzyme purified from the organism was a dodecamer in its active state and showed strong maltose-hydrolyzing activity at 100°C and pH 5.0. MalA was remarkably thermostable, with half-lives of 33.8 h, 10.6 h, and 1.8 h at 95°C, 100°C, and 105°C, respectively. Substrate specificity and kinetic studies of MalA with maltooligosaccharides indicated that MalA efficiently hydrolyzed maltose to maltopentaose, which is a typical characteristic of GH31-type α-glucosidases. However, glycogen or starch was not hydrolyzed. Reverse transcription-PCR, sugar uptake, and growth studies of the wild-type DSM639 and ΔmalEFG mutant on different sugars demonstrated that MalA located in the mal operon gene cluster is involved in maltose and starch metabolism in S. acidocaldarius. PMID:23396915

  3. Effects of logging activities on ecological water quality indicators in the Berasau River, Johor, Malaysia.

    PubMed

    Nor Zaiha, A; Mohd Ismid, M S; Salmiati; Shahrul Azri, M S

    2015-08-01

    Influence of deforestation on biodiversity of aquatic organisms was investigated in a stream in the Ulu Sedili Forest Reserve. The stream was monitored five (5) times from December 2011 until December 2012 with 2-month intervals. Sampling of benthic communities was carried out using rectangular dip net while water quality study using a YSI ProPlus meter and the rest were done in the laboratory. Physicochemical parameters and water quality index (WQI) calculation showed no significant difference among the investigated events. WQI classified the Berasau River between Class II (good) to III (moderate) of river water quality. In total, 603 individuals representing 25 taxa that were recorded with Decapods from genus Macrobrabchium were widely distributed. Several intolerant taxa, especially Ephemeroptera and Odonata, were also observed in this river. According to Pearson's correlation analysis, the richness and diversity indices were generally influenced by water quality parameters represented by WQI (P < 0.01). In conclusion, logging activities have strong attributes for variation in benthic macroinvertebrate assemblage. PMID:26154860

  4. Essential and nonessential sequences in malPp, a positively controlled promoter in Escherichia coli.

    PubMed

    Raibaud, O; Gutierrez, C; Schwartz, M

    1985-03-01

    A plasmid bearing the malPp promoter was digested with Bal31 to obtain a set of deletions with closely spaced endpoints in the upstream region of this promoter. Some of these deletions were sequenced, and their effect on malPQ expression was determined after having transferred them onto the chromosome. We found that a site which binds the cyclic AMP receptor protein in vitro and which is centered at position -93 with respect to the site of transcription initiation could be deleted without affecting malPQ expression. In contrast, the activity of the malPp promoter decreased abruptly when the deletions reached position -72. The downstream region of the promoter was analyzed by using a technique of "sequence replacement" which involved the selection of Mal+ pseudorevertants from strains which carried small deletions in the -25 region. The pseudorevertants, which expressed the malPQ operon in a manner indistinguishable from wild type, had grossly different sequences downstream from position -38, except for a few positions, some of which must be important for promoter function. By combining all presently available information, it is suggested that the malPp promoter contains three binding sites for its activator, the product of gene malT. These sites are defined by three quasi-identical hexanucleotides present in one orientation around position -37 and twice in the other orientation around positions -60 and -73. PMID:3156124

  5. X-ray structure of MalY from Escherichia coli: a pyridoxal 5'-phosphate-dependent enzyme acting as a modulator in mal gene expression.

    PubMed

    Clausen, T; Schlegel, A; Peist, R; Schneider, E; Steegborn, C; Chang, Y S; Haase, A; Bourenkov, G P; Bartunik, H D; Boos, W

    2000-03-01

    MalY represents a bifunctional pyridoxal 5'-phosphate-dependent enzyme acting as a beta-cystathionase and as a repressor of the maltose regulon. Here we present the crystal structures of wild-type and A221V mutant protein. Each subunit of the MalY dimer is composed of a large pyridoxal 5'-phosphate-binding domain and a small domain similar to aminotransferases. The structural alignment with related enzymes identifies residues that are generally responsible for beta-lyase activity and depicts a unique binding mode of the pyridoxal 5'-phosphate correlated with a larger, more flexible substrate-binding pocket. In a screen for MalY mutants with reduced mal repressor properties, mutations occurred in three clusters: I, 83-84; II, 181-189 and III, 215-221, which constitute a clearly distinguished region in the MalY crystal structure far away from the cofactor. The tertiary structure of one of these mutants (A221V) demonstrates that positional rearrangements are indeed restricted to regions I, II and III. Therefore, we propose that a direct protein-protein interaction with MalT, the central transcriptional activator of the maltose system, underlies MalY-dependent repression of the maltose system. PMID:10698925

  6. PARduino: a simple and inexpensive device for logging photosynthetically active radiation.

    PubMed

    Barnard, Holly R; Findley, Matthew C; Csavina, Janae

    2014-06-01

    Photosynthetically active radiation (PAR, 400-700 nm) is one of the primary controls of forest carbon and water relations. In complex terrain, PAR has high spatial variability. Given the high cost of commercial datalogging equipment, spatially distributed measurements of PAR have been typically modeled using geographic coordinates and terrain indices. Here, we present a design for a low-cost, field-deployable device for measuring and recording PAR built around an Arduino microcontroller-named PARduino. PARduino provides for widely distributed sensor arrays and tests the feasibility of using open-source, hobbyist-grade electronics for collecting scientific data. PARduino components include a quantum sensor, an EME Systems signal converter/amplifier and an Arduino Pro Mini microcontroller. Additional components include a real-time clock, a microSD Flash memory card and a custom printed circuit board. The components were selected for ease of assembly. We found strong agreement between the PARduino datalogger system and National Institute of Standards and Technology traceable sensors logged by an industry standard datalogger (slope = 0.99, SE < 0.01, P < 0.01; intercept = - 14.84, SE = 0.78, P < 0.01). The average difference between the two systems was 22.0 µmol m(-2) s(-1) with PARduino typically underestimating PAR. The average percentage difference between systems was 3.49%. On average, PARduino performed within the factory absolute calibration of the PAR sensor; however, larger errors occurred at low PAR levels. Using open-source technologies such as this can make it possible to develop a spatially distributed sensor network within the constraints of a typical research budget. PMID:24935916

  7. Field evaluation of active and passive direct uranium borehole logging systems

    SciTech Connect

    Wilson, R.D.; Cosby, M.S.; Stone, J.M.

    1980-05-01

    Thirty test holes were placed in a variety of geologic environments and for wide variations in ore zone grade, thickness, and uranium/radium disequilibrium condition. The ore zones of each test hole were core drilled with >90% core recovery. Core samples were analyzed for a number of trace, minor and major elemental constituents, and for several physical properties. A standard suite of geophysical logs was obtained prior to casing the test holes. Direct uranium logs were then obtained by the PGT, Sandia, IRT, and Century Geophysical sondes. All core and logging results have been written to a computerized data base. The data base was then used to produce various comparison plots and other forms of data evaluation. Calculation of the grade-thickness product for each ore zone and sonde type shows that the logging results are widely dispersed about the values obtained from the core assays. Results for the IRT sonde are systematically lower than core results, the Century sonde severely overestimates the grade-thickness product for very low grade zones, and the PGT sonde exhibits a systematic trend toward underestimating grade-thickness for higher grade (>1000 ppM) ore zones. The Sandia sonde shows no such systematic trends and agrees well with core results at the higher grades (1000 to 2500 ppM range). Neglecting the very large discrepancies observed, for example, with Century's sonde at low grade, or with IRT's sonde when malfunction was suspected, the four direct uranium logging sondes exhibited similar dispersions about the core results.Approximately 50 percent of the time the logging sondes are within +-30% of the core results while about 75% of the time they are within +-50%. A certain amount of this dispersion is due to the unfavorable borehole conditions and to the variety of geologic environments sampled.

  8. Structural and photoluminescence properties of Dy3+ co-doped and Eu2+ activated MAl2O4 (M = Ba, Ca, Sr) nanophosphors

    NASA Astrophysics Data System (ADS)

    Dejene, F. B.; Kebede, M. A.; Redi-Abshiro, M.; Kgarebe, B. V.

    2013-09-01

    Long afterglow alkaline earth aluminates MAl2O4:Eu, Dy (M: Ca, Sr, Ba) phosphors are generally synthesized by the solid-state process which is more feasible than other conventional processes in terms of operation and large-scale production. However, the constituents of phosphors synthesized using this process are usually not mixed well, the particles agglomerates and very high temperature requirement to synthesize the final powder make it undesirable. In order to circumvent these problems, MAl2O4:Eu, Dy (Ca, Ba, Sr) phosphors were prepared at low temperatures (500 °C) by the solution-combustion of corresponding metal nitrate-urea solution mixtures, over a time of 5-10 min. In order to elucidate the relationship between the constituent, structure and PL properties product's particle size, morphological and structural properties were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), energy dispersive X-ray spectrometer (EDS), while the characteristic luminescence properties were investigated using emission spectra. The low temperature monoclinic structure for both CaAl2O4 and SrAl2O4 and the hexagonal structure of BaAl2O4 were observed. The emission spectra of these phosphors indicated that all of them are broad band, and the only emission peaks around 448, 490 and 515 nm of CaAl2O4:Eu, Dy, BaAl2O4:Eu, Dy and SrAl2O4:Eu, Dy, respectively, are due to 5d → 4f transition of Eu2+. The decay curves implied that these phosphors contain fast, medium and slow-decay process. The Dy3+ trap levels may be considered to be responsible for the long afterglow phosphorescence at room temperature.

  9. Transaction Logging.

    ERIC Educational Resources Information Center

    Jones, S.; And Others

    1997-01-01

    Discusses the use of transaction logging in Okapi-related projects to allow search algorithms and user interfaces to be investigated, evaluated, and compared. A series of examples is presented, illustrating logging software for character-based and graphical user interface systems, and demonstrating the usefulness of relational database management…

  10. Genetic evidence for substrate and periplasmic-binding-protein recognition by the MalF and MalG proteins, cytoplasmic membrane components of the Escherichia coli maltose transport system.

    PubMed

    Treptow, N A; Shuman, H A

    1985-08-01

    We isolated mutants of Escherichia coli in which the maltose-binding protein (MBP) is no longer required for growth on maltose as the sole source of carbon and energy. These mutants were selected as Mal+ revertants of a strain which carries a deletion of the MBP structural gene, malE. In one class of these mutants, maltose is transported into the cell independently of MBP by the remaining components of the maltose system. The mutations in these strains map in either malF or malG. These genes code for two of the cytoplasmic membrane components of the maltose transport system. In some of the mutants, MBP actually inhibits maltose transport. We demonstrate that these mutants still transport maltose actively and in a stereospecific manner. These results suggest that the malF and malG mutations result in exposure of a substrate recognition site that is usually available only to substrates bound to MBP. PMID:3894331

  11. Design and evaluation of a location and activity log used for assessing personal exposure to air pollutants

    SciTech Connect

    Freeman, N.C.; Waldman, J.M.; Lioy, P.J. )

    1991-07-01

    As part of the Total Human Environmental Exposure Study (THEES), a self-administered questionnaire was developed to identify sources of exposure to BaP and PM-10. Thirteen participants in ten households completed a daily personal activity log for fourteen consecutive days during January 1988. Validation of the instrument was obtained in three ways: internal questionnaire checks, comparison with pre-sampling estimates of time/activity patterns, and comparison with earlier studies. The log was found to be easy for participants to use and reliable in most of its questions. Effectiveness of the log in identifying sources of exposure was enhanced by having most responses in the form of continuous variables. While most of personal exposure to both BaP and PM-10 could be attributed to outdoor sources, a variety of household sources and personal activities were also identified. Higher levels of PM-10 were associated with use of unvented kerosene space heaters and coalstoves, stove-top cooking, ETS, and house cleaning. Personal exposure to BaP was primarily associated with ambient levels, and secondarily with ETS, coalstove use, and cooking activities.

  12. Identification and characterization of the active hydrothermal deposits in Okinawa Trough, SW Japan: Estimates from logging-while-drilling

    NASA Astrophysics Data System (ADS)

    Saito, S.; Sanada, Y.; Moe, K.; Kido, Y. N.; Hamada, Y.; Kumagai, H.; Nozaki, T.; Takai, K.; Suzuki, K.

    2015-12-01

    A scientific drilling expedition was conducted at an active hydrothermal field on the Iheya-North Knoll by D/V Chikyu in 2014 (Expedition 907) as a part of "Next-generation Technology for Ocean Resources Survey" of the Cross-ministerial Strategic Innovation Promotion Program. During the expedition logging while drilling (LWD) was deployed to constrain the area of the fluid reservoir beneath seafloor followed by three coring holes down to 150 meter below the seafloor (mbsf). The LWD system is composed of arcVISION for resistivity and natural gamma ray measurement and TeleScope for real-time transmission of drilling parameters and arcVISION data. Five sites (C9011-15) at the Iheya-North Original Site and one site (C9016) at Aki Site were drilled with LWD. At C9012 and C9016, the arcVISION detected temperature anomaly up to 84℃ at 234 mbsf and up to 39℃ at 80 mbsf, respectively. The temperature quickly increases at that depth and it would reflect the existence of high-temperature heat source along borehole. Due to the continuous fluid circulation during drilling, the measured temperature does not indicate in-situ temperature, but it reflects the heat disturbed by the cold circulated water instead. High quality resistivity and natural gamma ray data were acquired at six sites. The log curves at Site C9016 show characteristic response; the natural gamma ray log exhibits extremely high radiation (>500 gAPI) at 7-13 and 23-31 mbsf (Zone A). In the underlying interval of 31-40 mbsf, the resistivity log exhibits extremely low value (<0.2 ohm-m) (Zone B). Then the resistivity log exhibits higher value (~10 ohm-m) and the natural gamma ray log shows very low radiation (<50 gAPI) at the interval of 41-48 mbsf (Zone C). The log characteristics in Zone A, B, and C can be interpreted as a series of K-rich alteration zone, sulfide zone, and low-K hard (silicified) sediments, respectively. The LWD-based lithological interpretation was confirmed by the following core description

  13. 7 CFR 1421.419 - MAL or LDP servicing.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...-MARKETING ASSISTANCE LOANS AND LOAN DEFICIENCY PAYMENTS FOR 2008 THROUGH 2012 Designated Marketing... MAL maturity. (2) Maintain the MAL or LDP documents according to FSA requirements. (3) Transmit...

  14. 7 CFR 1421.419 - MAL or LDP servicing.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...-MARKETING ASSISTANCE LOANS AND LOAN DEFICIENCY PAYMENTS FOR 2008 THROUGH 2012 Designated Marketing... MAL maturity. (2) Maintain the MAL or LDP documents according to FSA requirements. (3) Transmit...

  15. Human saccadic eye movements and tracking by active foveation in log polar space

    NASA Astrophysics Data System (ADS)

    Lim, Fee-Lee; Venkatesh, Svetha; West, Geoffrey A. W.

    1996-04-01

    One of the possible models of the human visual system (HVS) in the computer vision literature has a high resolution fovea and exponentially decreasing resolution periphery. The high resolution fovea is used to extract necessary information in order to solve a vision task and the periphery may be used to detect motion. To obtain the desired information, the fovea is guided by the contents of the scene and other knowledge to position the fovea over areas of interest. These eye movements are called saccades and corrective saccades. A two stage process has been implemented as a mechanism for changing foveation in log polar space. Initially, the open loop stage roughly foveates on the best interest feature and then the closed loop stage is invoked to accurately iteratively converge onto the foveation point. The open loop stage developed for the foveation algorithm is applied to saccadic eye movements and a tracking system. Log polar space is preferred over Cartesian space as: (1) it simultaneously provides high resolution and a wide viewing angle; and (2) feature invariance occurs in the fovea which simplifies the foveation process.

  16. Gravimetry logging

    SciTech Connect

    Lyle, W.D.

    1989-03-07

    This patent describes a method for conducting a gravimetry survey of an earth formation, comprising the steps of: continuously traversing the formation with a gravity logging tool having at least two piezoelectric force transducers mounted at spaced-apart positions within the tool, exciting the piezoelectric transducers to vibrate at a characteristic resonant frequency, measuring the periods of vibration of the piezoelectric transducers as the logging tool continuously traverses the formation, the periods of vibration changing in response to the force exerted on the piezoelectric transducer by the acceleration of gravity and acceleration due to tool motion along the formation, and determining the difference in the measured periods of vibration of the piezoelectric transducers compensated for temperature relating force to the periods of vibration within the formation.

  17. A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling.

    PubMed

    Ní Cheallaigh, Clíona; Sheedy, Frederick J; Harris, James; Muñoz-Wolf, Natalia; Lee, Jinhee; West, Kim; McDermott, Eva Palsson; Smyth, Alicia; Gleeson, Laura E; Coleman, Michelle; Martinez, Nuria; Hearnden, Claire H A; Tynan, Graham A; Carroll, Elizabeth C; Jones, Sarah A; Corr, Sinéad C; Bernard, Nicholas J; Hughes, Mark M; Corcoran, Sarah E; O'Sullivan, Mary; Fallon, Ciara M; Kornfeld, Hardy; Golenbock, Douglas; Gordon, Stephen V; O'Neill, Luke A J; Lavelle, Ed C; Keane, Joseph

    2016-02-16

    Humans that are heterozygous for the common S180L polymorphism in the Toll-like receptor (TLR) adaptor Mal (encoded by TIRAP) are protected from a number of infectious diseases, including tuberculosis (TB), whereas those homozygous for the allele are at increased risk. The reason for this difference in susceptibility is not clear. We report that Mal has a TLR-independent role in interferon-gamma (IFN-γ) receptor signaling. Mal-dependent IFN-γ receptor (IFNGR) signaling led to mitogen-activated protein kinase (MAPK) p38 phosphorylation and autophagy. IFN-γ signaling via Mal was required for phagosome maturation and killing of intracellular Mycobacterium tuberculosis (Mtb). The S180L polymorphism, and its murine equivalent S200L, reduced the affinity of Mal for the IFNGR, thereby compromising IFNGR signaling in macrophages and impairing responses to TB. Our findings highlight a role for Mal outside the TLR system and imply that genetic variation in TIRAP may be linked to other IFN-γ-related diseases including autoimmunity and cancer. PMID:26885859

  18. A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling

    PubMed Central

    Ní Cheallaigh, Clíona; Sheedy, Frederick J.; Harris, James; Muñoz-Wolf, Natalia; Lee, Jinhee; West, Kim; McDermott, Eva Palsson; Smyth, Alicia; Gleeson, Laura E.; Coleman, Michelle; Martinez, Nuria; Hearnden, Claire H.A.; Tynan, Graham A.; Carroll, Elizabeth C.; Jones, Sarah A.; Corr, Sinéad C.; Bernard, Nicholas J.; Hughes, Mark M.; Corcoran, Sarah E.; O’Sullivan, Mary; Fallon, Ciara M.; Kornfeld, Hardy; Golenbock, Douglas; Gordon, Stephen V.; O’Neill, Luke A.J.; Lavelle, Ed C.; Keane, Joseph

    2016-01-01

    Summary Humans that are heterozygous for the common S180L polymorphism in the Toll-like receptor (TLR) adaptor Mal (encoded by TIRAP) are protected from a number of infectious diseases, including tuberculosis (TB), whereas those homozygous for the allele are at increased risk. The reason for this difference in susceptibility is not clear. We report that Mal has a TLR-independent role in interferon-gamma (IFN-γ) receptor signaling. Mal-dependent IFN-γ receptor (IFNGR) signaling led to mitogen-activated protein kinase (MAPK) p38 phosphorylation and autophagy. IFN-γ signaling via Mal was required for phagosome maturation and killing of intracellular Mycobacterium tuberculosis (Mtb). The S180L polymorphism, and its murine equivalent S200L, reduced the affinity of Mal for the IFNGR, thereby compromising IFNGR signaling in macrophages and impairing responses to TB. Our findings highlight a role for Mal outside the TLR system and imply that genetic variation in TIRAP may be linked to other IFN-γ-related diseases including autoimmunity and cancer. PMID:26885859

  19. Integrating electrodermal biofeedback into pharmacologic treatment of grand mal seizures

    PubMed Central

    Scrimali, Tullio; Tomasello, Damiana; Sciuto, Massimo

    2015-01-01

    Electrodermal activity (EDA) and electrodermal biofeedback, when integrated with pharmacologic treatments, indicate promising methods for the treatment of grand mal seizures. They can be used to monitor patient arousal and help patients learn new strategies to better cope with stress and anxiety. Our proposed method can possibly reduce the number of crises for patients who are dependent on pharmacologic therapy and can improve their quality of life. This article describes the scientific background of electrodermal monitoring and electrodermal biofeedback for patients affected by grand mal seizures. In this study, we have reported a clinical case study. The patient was treated for 2 years with electrodermal biofeedback to augment pharmacologic treatments. The trial has been designed in accordance with “n = 1 case study research”. Our results have shown that our methods could achieve a significant reduction in grand mal seizures and sympathetic arousal when applied. The patient under consideration was also relaxed and exhibited greater competency to cope with stress. Additionally, the patient’s sense of mastery and self-efficacy was enhanced. PMID:26029078

  20. Integrating electrodermal biofeedback into pharmacologic treatment of grand mal seizures.

    PubMed

    Scrimali, Tullio; Tomasello, Damiana; Sciuto, Massimo

    2015-01-01

    Electrodermal activity (EDA) and electrodermal biofeedback, when integrated with pharmacologic treatments, indicate promising methods for the treatment of grand mal seizures. They can be used to monitor patient arousal and help patients learn new strategies to better cope with stress and anxiety. Our proposed method can possibly reduce the number of crises for patients who are dependent on pharmacologic therapy and can improve their quality of life. This article describes the scientific background of electrodermal monitoring and electrodermal biofeedback for patients affected by grand mal seizures. In this study, we have reported a clinical case study. The patient was treated for 2 years with electrodermal biofeedback to augment pharmacologic treatments. The trial has been designed in accordance with "n = 1 case study research". Our results have shown that our methods could achieve a significant reduction in grand mal seizures and sympathetic arousal when applied. The patient under consideration was also relaxed and exhibited greater competency to cope with stress. Additionally, the patient's sense of mastery and self-efficacy was enhanced. PMID:26029078

  1. Maltase protein of Ogataea (Hansenula) polymorpha is a counterpart to the resurrected ancestor protein ancMALS of yeast maltases and isomaltases.

    PubMed

    Viigand, Katrin; Visnapuu, Triinu; Mardo, Karin; Aasamets, Anneli; Alamäe, Tiina

    2016-08-01

    Saccharomyces cerevisiae maltases use maltose, maltulose, turanose and maltotriose as substrates, isomaltases use isomaltose, α-methylglucoside and palatinose and both use sucrose. These enzymes are hypothesized to have evolved from a promiscuous α-glucosidase ancMALS through duplication and mutation of the genes. We studied substrate specificity of the maltase protein MAL1 from an earlier diverged yeast, Ogataea polymorpha (Op), in the light of this hypothesis. MAL1 has extended substrate specificity and its properties are strikingly similar to those of resurrected ancMALS. Moreover, amino acids considered to determine selective substrate binding are highly conserved between Op MAL1 and ancMALS. Op MAL1 represents an α-glucosidase in which both maltase and isomaltase activities are well optimized in a single enzyme. Substitution of Thr200 (corresponds to Val216 in S. cerevisiae isomaltase IMA1) with Val in MAL1 drastically reduced the hydrolysis of maltose-like substrates (α-1,4-glucosides), confirming the requirement of Thr at the respective position for this function. Differential scanning fluorimetry (DSF) of the catalytically inactive mutant Asp199Ala of MAL1 in the presence of its substrates and selected monosaccharides suggested that the substrate-binding pocket of MAL1 has three subsites (-1, +1 and +2) and that binding is strongest at the -1 subsite. The DSF assay results were in good accordance with affinity (Km ) and inhibition (Ki ) data of the enzyme for tested substrates, indicating the power of the method to predict substrate binding. Deletion of either the maltase (MAL1) or α-glucoside permease (MAL2) gene in Op abolished the growth of yeast on MAL1 substrates, confirming the requirement of both proteins for usage of these sugars. © 2016 The Authors. Yeast published by John Wiley & Sons, Ltd. PMID:26919272

  2. Virus Characterization by FFF-MALS Assay

    NASA Astrophysics Data System (ADS)

    Razinkov, Vladimer

    2009-03-01

    Adequate biophysical characterization of influenza virions is important for vaccine development. The influenza virus vaccines are produced from the allantoic fluid of developing chicken embryos. The process of viral replication produces a heterogeneous mixture of infectious and non-infectious viral particles with varying states of aggregation. The study of the relative distribution and behavior of different subpopulations and their inter-correlation can assist in the development of a robust process for a live virus vaccine. This report describes a field flow fractionation and multiangle light scattering (FFF-MALS) method optimized for the analysis of size distribution and total particle counts. A method using a combination of asymmetric flow field-flow fractionation (AFFFF) and multiangle light scattering (MALS) techniques has been shown to improve the estimation of virus particle counts and the amount of aggregated virus in laboratory samples. The FFF-MALS method was compared with several other methods such as transmission electron microscopy (TEM), atomic force microscopy (AFM), size exclusion chromatography followed by MALS (SEC-MALS), quantitative reverse transcription polymerase chain reaction (RT Q-PCR), median tissue culture dose (TCID(50)), and the fluorescent focus assay (FFA). The correlation between the various methods for determining total particle counts, infectivity and size distribution is reported. The pros and cons of each of the analytical methods are discussed.

  3. MAL2 and tumor protein D52 (TPD52) are frequently overexpressed in ovarian carcinoma, but differentially associated with histological subtype and patient outcome

    PubMed Central

    2010-01-01

    Background The four-transmembrane MAL2 protein is frequently overexpressed in breast carcinoma, and MAL2 overexpression is associated with gain of the corresponding locus at chromosome 8q24.12. Independent expression microarray studies predict MAL2 overexpression in ovarian carcinoma, but these had remained unconfirmed. MAL2 binds tumor protein D52 (TPD52), which is frequently overexpressed in ovarian carcinoma, but the clinical significance of MAL2 and TPD52 overexpression was unknown. Methods Immunohistochemical analyses of MAL2 and TPD52 expression were performed using tissue microarray sections including benign, borderline and malignant epithelial ovarian tumours. Inmmunohistochemical staining intensity and distribution was assessed both visually and digitally. Results MAL2 and TPD52 were significantly overexpressed in high-grade serous carcinomas compared with serous borderline tumours. MAL2 expression was highest in serous carcinomas relative to other histological subtypes, whereas TPD52 expression was highest in clear cell carcinomas. MAL2 expression was not related to patient survival, however high-level TPD52 staining was significantly associated with improved overall survival in patients with stage III serous ovarian carcinoma (log-rank test, p < 0.001; n = 124) and was an independent predictor of survival in the overall carcinoma cohort (hazard ratio (HR), 0.498; 95% confidence interval (CI), 0.34-0.728; p < 0.001; n = 221), and in serous carcinomas (HR, 0.440; 95% CI, 0.294-0.658; p < 0.001; n = 182). Conclusions MAL2 is frequently overexpressed in ovarian carcinoma, and TPD52 overexpression is a favourable independent prognostic marker of potential value in the management of ovarian carcinoma patients. PMID:20846453

  4. The mean age of petit mal epilepsy

    PubMed Central

    Syeda, Afsarunnesa; Karim, Md. Rezaul

    2016-01-01

    Objective: Petit mal epilepsy or absence seizures involve brief, sudden lapses of consciousness and most often occurs in people under age of 20 years. This study was done to find out the most likely significant age affected by petit mal epilepsy and whether they had higher rate of behavioral, educational, and social problems. Materials and Methods: We run tests on total 32 patients (male 16 and female 16) from newborns to 20 years of age. Results: The most affected ages were from 4 to 9 years and both genders were equally affected. They have higher rate of behavioral, educational, and social problems, and most likely recovering ages from the disease were from 15 to 20 years. Conclusion: These findings could contribute in diagnosis and treatment of Petit Mal Epilepsy, as it often misinterpreted as daydreaming or inattention.

  5. NMR logging apparatus

    DOEpatents

    Walsh, David O; Turner, Peter

    2014-05-27

    Technologies including NMR logging apparatus and methods are disclosed. Example NMR logging apparatus may include surface instrumentation and one or more downhole probes configured to fit within an earth borehole. The surface instrumentation may comprise a power amplifier, which may be coupled to the downhole probes via one or more transmission lines, and a controller configured to cause the power amplifier to generate a NMR activating pulse or sequence of pulses. Impedance matching means may be configured to match an output impedance of the power amplifier through a transmission line to a load impedance of a downhole probe. Methods may include deploying the various elements of disclosed NMR logging apparatus and using the apparatus to perform NMR measurements.

  6. The ALFA (Activity Log Files Aggregation) Toolkit: A Method for Precise Observation of the Consultation

    PubMed Central

    2008-01-01

    Background There is a lack of tools to evaluate and compare Electronic patient record (EPR) systems to inform a rational choice or development agenda. Objective To develop a tool kit to measure the impact of different EPR system features on the consultation. Methods We first developed a specification to overcome the limitations of existing methods. We divided this into work packages: (1) developing a method to display multichannel video of the consultation; (2) code and measure activities, including computer use and verbal interactions; (3) automate the capture of nonverbal interactions; (4) aggregate multiple observations into a single navigable output; and (5) produce an output interpretable by software developers. We piloted this method by filming live consultations (n = 22) by 4 general practitioners (GPs) using different EPR systems. We compared the time taken and variations during coded data entry, prescribing, and blood pressure (BP) recording. We used nonparametric tests to make statistical comparisons. We contrasted methods of BP recording using Unified Modeling Language (UML) sequence diagrams. Results We found that 4 channels of video were optimal. We identified an existing application for manual coding of video output. We developed in-house tools for capturing use of keyboard and mouse and to time stamp speech. The transcript is then typed within this time stamp. Although we managed to capture body language using pattern recognition software, we were unable to use this data quantitatively. We loaded these observational outputs into our aggregation tool, which allows simultaneous navigation and viewing of multiple files. This also creates a single exportable file in XML format, which we used to develop UML sequence diagrams. In our pilot, the GP using the EMIS LV (Egton Medical Information Systems Limited, Leeds, UK) system took the longest time to code data (mean 11.5 s, 95% CI 8.7-14.2). Nonparametric comparison of EMIS LV with the other systems showed

  7. The Pediatric Motor Activity Log-Revised: Assessing Real-world Arm Use in Children with Cerebral Palsy

    PubMed Central

    Uswatte, Gitendra; Taub, Edward; Griffin, Angi; Vogtle, Laura; Rowe, Jan; Barman, Joydip

    2012-01-01

    Objective Widely accepted models of disability suggest that actual use of an impaired upper-extremity in everyday life frequently deviates from its motor capacity, as measured by laboratory tests. Yet, direct measures of real-world use of an impaired upper-extremity are rare in pediatric neurorehabilitation. This paper examines how well the Pediatric Motor Activity Log-Revised (PMAL-R) measures this parameter, when the PMAL-R is administered as a structured interview as originally designed. Design Parents of sixty children between 2–8 years with upper-extremity hemiparesis due to cerebral palsy (CP) completed the PMAL-R twice. Additionally, the children were videotaped during play structured to elicit spontaneous arm use. More-affected arm use was scored by masked raters; it was thought to reflect everyday activity since no cues were given about which arm to employ. Testing sessions were separated by 3 weeks, during which 29 children received upper-extremity rehabilitation and 31 did not. Results The PMAL-R had high internal consistency (Cronbach's α = .93) and test-retest reliability (r = .89). Convergent validity was supported by a strong correlation between changes in PMAL-R scores and more-affected arm use during play, r(53) = .5, p < .001. Conclusions The PMAL-R interview is a reliable and valid measure of upper-extremity pediatric neurorehabilitation outcome. PMID:22686553

  8. Structural evaluation of BTK and PKCδ mediated phosphorylation of MAL at positions Tyr86 and Tyr106.

    PubMed

    Paracha, Rehan Zafar; Ali, Amjad; Ahmad, Jamil; Hussain, Riaz; Niazi, Umar; Muhammad, Syed Aun

    2014-08-01

    A number of diseases including sepsis, rheumatoid arthritis, diabetes, cardiovascular diseases and hyperinflammatory immune disorders have been associated with Toll like receptor (TLR) 2 and TLR4. Endogenous adaptor protein known as MyD88 adapter-like protein (MAL) bind exclusively to the cytosolic portions of TLR2 and TLR4 to initiate downstream signalling. Brutons tyrosine kinase (BTK) and protein kinase C delta (PKCδ) have been implicated to phosphorylate MAL and activate it to initiate downstream signalling. BTK has been associated with phosphorylation at positions Tyr86 and Tyr106, necessary for the activation of MAL but definite residual target of PKCδ in MAL is still to be explored. To produce a better understanding of the functional domains involved in the formation of MAL-kinase complexes, computer-aided studies were used to characterize the protein-protein interactions (PPIs) of phosphorylated BTK and PKCδ with MAL. Docking and physicochemical studies indicated that BTK was involved in close contact with Tyr86 and Tyr106 of MAL whereas PKCδ may phosphorylate Tyr106 only. Moreover, the electrostatics charge distribution of binding interfaces of BTK and PKCδ were distinct but compatible with respective regions of MAL. Our results implicate that position of Tyr86 is specifically phosphorylated by BTK whereas Tyr106 can be phosphorylated by competitive action of both BTK and PKCδ. Additionally, the residues of MAL which are necessary for interaction with TLR2, TLR4, MyD88 and SOCS-1 also play their roles in maintaining interaction with kinases and can be targeted in future to reduce TLR2 and TLR4 induced pathological responses. PMID:24840642

  9. Mal de Debarquement (Sickness of Disembarkment)

    MedlinePlus

    ... that will counter the different, rhythmical shipboard movements. Adaptation to such movement is sometimes referred to as ... Shupak A. “Clinical features of mal de débarquement: adaptation and habituation to sea conditions.” Journal of Vestibular ...

  10. Mal de debarquement syndrome: a systematic review.

    PubMed

    Van Ombergen, Angelique; Van Rompaey, Vincent; Maes, Leen K; Van de Heyning, Paul H; Wuyts, Floris L

    2016-05-01

    Mal de debarquement (MdD) is a subjective perception of self-motion after exposure to passive motion, in most cases sea travel, hence the name. Mal de debarquement occurs quite frequently in otherwise healthy individuals for a short period of time (several hours). However, in some people symptoms remain for a longer period of time or even persist and this is then called mal de debarquement syndrome (MdDS). The underlying pathogenesis is poorly understood and therefore, treatment options are limited. In general, limited studies have focused on the topic, but the past few years more and more interest has been attributed to MdDS and its facets, which is reflected by an increasing number of papers. Till date, some interesting reviews on the topic have been published, but a systematic review of the literature is lacking and could help to address the shortcomings and flaws of the current literature. We here present a systematic review of MdD(S) based on a systematic search of medical databases employing predefined criteria, using the terms "mal de debarquement" and "sea legs". Based on this, we suggest a list of criteria that could aid healthcare professionals in the diagnosis of MdDS. Further research needs to address the blank gaps by addressing how prevalent MdD(S) really is, by digging deeper into the underlying pathophysiology and setting up prospective, randomized placebo-controlled studies to evaluate the effectiveness of possible treatment strategies. PMID:26559820

  11. Mal'tsev algebras and triality

    NASA Astrophysics Data System (ADS)

    Paal, Eugen

    2012-02-01

    A concept of the Mal'tsev pair is presented. This concept is based on the generalized Maurer-Cartan equations of a local analytic Moufang loop. The triality can be seen as a fundamental property of such pairs. Based on triality, the Yamagutian is constructed. Properties of the Yamagutian are studied.

  12. Portable device for detection of petit mal epilepsy

    NASA Technical Reports Server (NTRS)

    Smith, R. G.; Houge, J. C.; Webster, J. G.

    1979-01-01

    A portable device that analyzes the electroencephalogram to determine if petit mal epilepsy waveforms are present is developed and tested. Clinicians should find it useful in diagnosing seizure activity of their patients. The micropower, battery-operated, portable device indicates a seizure has occurred if three criteria are satisfied: (1) frequencies of 2.5-7 Hz, (2) large-amplitude waves, and (3) minimum number of waves per second. Levels and counts are adjustable, thus insuring high reliability against noise artifacts and permitting each subject to be individually fitted. The device has shown promise in giving the patient a possible mechanism of seizure control or suppression.

  13. VIP17/MAL expression modulates epithelial cyst formation and ciliogenesis

    PubMed Central

    Takiar, Vinita; Mistry, Kavita; Carmosino, Monica; Schaeren-Wiemers, Nicole

    2012-01-01

    The polarized organization of epithelial cells is required for vectorial solute transport and may be altered in renal cystic diseases. Vesicle integral protein of 17 kDa (VIP17/MAL) is involved in apical vesicle transport. VIP17/MAL overexpression in vivo results in renal cystogenesis of unknown etiology. Renal cystogenesis can occur as a consequence of defects of the primary cilium. To explore the role of VIP17/MAL in renal cystogenesis and ciliogenesis, we examined the polarization and ciliary morphology of wild-type and VIP17/MAL overexpressing Madin-Darby canine kidney renal epithelial cells grown in two-dimensional (2D) and three-dimensional (3D) cyst culture. VIP17/MAL is apically localized when expressed in cells maintained in 2D and 3D culture. VIP17/MAL overexpressing cells produce more multilumen cysts compared with controls. While the distributions of basolateral markers are not affected, VIP17/MAL expression results in aberrant sorting of the apical marker gp135 to the primary cilium. VIP17/MAL overexpression is also associated with shortened or absent cilia. Immunofluorescence analysis performed on kidney sections from VIP17/MAL transgenic mice also demonstrates fewer and shortened cilia within dilated lumens (P < 0.01). These studies demonstrate that VIP17/MAL overexpression results in abnormal cilium and cyst development, in vitro and in vivo, suggesting that VIP17/MAL overexpressing mice may develop cysts secondary to a ciliary defect. PMID:22895261

  14. Validity, Responsiveness, Minimal Detectable Change, and Minimal Clinically Important Change of the Pediatric Motor Activity Log in Children with Cerebral Palsy

    ERIC Educational Resources Information Center

    Lin, Keh-chung; Chen, Hui-fang; Chen, Chia-ling; Wang, Tien-ni; Wu, Ching-yi; Hsieh, Yu-wei; Wu, Li-ling

    2012-01-01

    This study examined criterion-related validity and clinimetric properties of the Pediatric Motor Activity Log (PMAL) in children with cerebral palsy. Study participants were 41 children (age range: 28-113 months) and their parents. Criterion-related validity was evaluated by the associations between the PMAL and criterion measures at baseline and…

  15. Learning Logs

    ERIC Educational Resources Information Center

    Heuser, Daniel

    2005-01-01

    Just what do children get out of inquiry? Good inquiry activities help students hone their inquiry abilities and teach them about the nature of science. But inquiry is also a way to teach science content, and teachers need to know if this instruction is helping children gain these important ideas. So, how do teachers know what students are…

  16. Logging Activity in the Trinational Amazonian Region of Pando/Bolivia, Acre and Rond“nia/Brazil, and Madre de Dios/Peru: Analysis of Existing Data

    NASA Astrophysics Data System (ADS)

    Mendoza, E.; Brilhante, S. H.; Brown, I.; Peralta, R.; Rivero, S.; Melendez, N.

    2002-12-01

    Logging activity in the trinational southwestern Amazonia will grow in importance as a driver of regional land-use change as expanding road access facilitates both timber extraction and transport to international markets. Official data on current activity in this ~50 million ha region are limited and inconsistent with differences as much as twenty-fold between official estimates; nevertheless, they serve as guides for understanding the relative magnitude of logging activities. For 2000, an estimated 5 million m3 of timber were commercialized in Rondonia, 400,000 m3 in Acre, Brazil, and 200,000 m3 for the combined departments of Pando, Bolivia and Madre de Dios, Peru. About 70% of this timber originates from clear cutting done for pasture and agriculture activities, nearly a third from unregulated selective logging, and only 2% from managed selective logging. Eight timber species are preferentially extracted. The total area for timber concessions in Acre, Pando and Madre de Dios extends to about 4 million ha for a potential timber supply of 65 million m3. About 150,000 m3/yr of illegal timber is confiscated by federal and state agencies in Acre, Pando and Madre de Dios. Problems of enforcement in the region are due principally to the lack of trained personnel and little cooperation among agencies of the three countries. Proposed development plans indicate a 3- to >10-fold increase in logging activity in the Acre and Pando regions during the coming decade. More detailed studies are urgently needed to guide sustainable development of this resource in southwestern Amazonia.

  17. Determination of depth, permeability, and fluid pressure of hydraulically active fractures in the COSC-1 borehole and their correlation with chemical and geophysical logging data

    NASA Astrophysics Data System (ADS)

    Tsang, Chin-Fu; Doughty, Christine; Rosberg, Jan-Erik; Berthet, Theo; Juhlin, Christopher; Niemi, Auli

    2016-04-01

    The Flowing Fluid Electricity Conductivity (FFEC) logging method has been applied to the 2.5-km fully-cored COSC-1 borehole in Sweden, both during and after the drilling period. The method is based on the fact that the drilling fluid has a lower electric conductivity (EC) value (about 200 μS/cm) compared to the formation water. Thus, by scanning several times along the borehole while it is being pumped at a low rate, Q, the locations of inflow zones can be identified as EC peaks at these depths. An analysis of the shape of the EC peaks will yield the local inflow rates and the formation water EC at each of the inflow zones. Further, by conducting the logging more than once with two values of Q, the initial or inherent fluid pressure at each inflow zone can be calculated. In the case of the COSC-1 borehole, the method has identified nine discrete inflow zones between 250 m depth and the borehole bottom of 2500 m depth. The permeability values are small and spread over more than one order of magnitude. The fluid pressures in the inflow zones show two groups of similar values with the shallow inflow zones having a higher pressure than those in the deeper part of the borehole. Correlation of the FFEC logging results with other information and data from the COSC-1 borehole are underway. First, rock cores were carefully examined at the depths of the inflow zones identified by FFEC logging. We were able to identify the fractures which may be responsible for the flow. It appears that each inflow zone can be correlated with one single fracture. The cores with these hydraulically active fractures have been transferred to the laboratory for detailed study. Second, COSC-1 fracture logs were reviewed. The majority of the fractures in the borehole are not hydraulically active and the active ones represent only about 1-2 % of the total number of fractures, consistent with previous statistical studies of fractures in crystalline rocks. Breakout logs were also studied and it

  18. The HSP70 Modulator MAL3-101 Inhibits Merkel Cell Carcinoma

    PubMed Central

    Adam, Christian; Baeurle, Anne; Brodsky, Jeffrey L.; Wipf, Peter; Schrama, David

    2014-01-01

    Merkel Cell Carcinoma (MCC) is a rare and highly aggressive neuroendocrine skin cancer for which no effective treatment is available. MCC represents a human cancer with the best experimental evidence for a causal role of a polyoma virus. Large T antigens (LTA) encoded by polyoma viruses are oncoproteins, which are thought to require support of cellular heat shock protein 70 (HSP70) to exert their transforming activity. Here we evaluated the capability of MAL3-101, a synthetic HSP70 inhibitor, to limit proliferation and survival of various MCC cell lines. Remarkably, MAL3-101 treatment resulted in considerable apoptosis in 5 out of 7 MCC cell lines. While this effect was not associated with the viral status of the MCC cells, quantitative mRNA expression analysis of the known HSP70 isoforms revealed a significant correlation between MAL3-101 sensitivity and HSC70 expression, the most prominent isoform in all cell lines. Moreover, MAL3-101 also exhibited in vivo antitumor activity in an MCC xenograft model suggesting that this substance or related compounds are potential therapeutics for the treatment of MCC in the future. PMID:24694787

  19. Reconstitution of maltose transport in malB and malA mutants of Escherichia coli.

    PubMed

    Brass, J M

    1982-01-01

    Pretreatment of lamB cells for 3 h with 10 mM Tris, pH 7.2, containing 25 mM Ca++ resulted in a Ca++-induced shift of the apparent Km of the maltose transport system from about 100 microM to about 15 microM. In contrast to maltose transport in untreated cells, that of Ca++-treated lamB cells was inhibited by anti-MBP (maltose-binding protein) antibodies. The calcium-induced permeability increase of the outer membrane allowed reconstitution of maltose transport in a malE mutant upon exposure to shock fluid or purified MBP. The efficiency of reconstitution, as judged by the Km of the maltose transport system in reconstituted cells, was rather high (Km = 5 microM). Vmax was around 20% of the wild-type. The rapid increase in maltose transport between 2' and 30' of incubation with shock fluid indicated that MBP readily entered the periplasm of Ca++-treated cells. Maltose transport continued for at least 1 h after washing the reconstituted cells. Surprisingly, Ca++ treatment also seemed to allow partial reconstitution of maltose transport in strain SF1701 malT::Tn10 after incubation with cell-free extracts of strain pop1740 malB,malTc. PMID:7041740

  20. The α-Glucan Phosphorylase MalP of Corynebacterium glutamicum Is Subject to Transcriptional Regulation and Competitive Inhibition by ADP-Glucose

    PubMed Central

    Clermont, Lina; Macha, Arthur; Müller, Laura M.; Derya, Sami M.; von Zaluskowski, Philipp; Eck, Alexander; Eikmanns, Bernhard J.

    2015-01-01

    ABSTRACT α-Glucan phosphorylases contribute to degradation of glycogen and maltodextrins formed in the course of maltose metabolism in bacteria. Accordingly, bacterial α-glucan phosphorylases are classified as either glycogen or maltodextrin phosphorylase, GlgP or MalP, respectively. GlgP and MalP enzymes follow the same catalytic mechanism, and thus their substrate spectra overlap; however, they differ in their regulation: GlgP genes are constitutively expressed and the enzymes are controlled on the activity level, whereas expression of MalP genes are transcriptionally controlled in response to the carbon source used for cultivation. We characterize here the modes of control of the α-glucan phosphorylase MalP of the Gram-positive Corynebacterium glutamicum. In accordance to the proposed function of the malP gene product as MalP, we found transcription of malP to be regulated in response to the carbon source. Moreover, malP transcription is shown to depend on the growth phase and to occur independently of the cell glycogen content. Surprisingly, we also found MalP activity to be tightly regulated competitively by the presence of ADP-glucose, an intermediate of glycogen synthesis. Since the latter is considered a typical feature of GlgPs, we propose that C. glutamicum MalP acts as both maltodextrin and glycogen phosphorylase and, based on these findings, we question the current system for classification of bacterial α-glucan phosphorylases. IMPORTANCE Bacterial α-glucan phosphorylases have been classified conferring to their purpose as either glycogen or maltodextrin phosphorylases. We found transcription of malP in C. glutamicum to be regulated in response to the carbon source, which is recognized as typical for maltodextrin phosphorylases. Surprisingly, we also found MalP activity to be tightly regulated competitively by the presence of ADP-glucose, an intermediate of glycogen synthesis. The latter is considered a typical feature of GlgPs. These findings

  1. Enhanced carbon-oxygen log interpretations using supplemental log curves

    SciTech Connect

    Wyatt, D.F. Jr.; Jacobson, L.A.; Fox, P.

    1994-12-31

    Supplemental measurements from induced nuclear spectrometry tools are examined to demonstrate what additional information they provide about the well and reservoir conditions. Logs in shut-in wells from Indonesia provide examples of oxygen activation measurements showing cross-flow from one reservoir to another via open perforations. Leaking squeezed perforations were also observed. An example from Alaska shows radioactive scale build-up in the casing which spectral analysis identifies as a mixture of uranium and thorium salts. Another log, where the casing fluid was replaced with crude oil, demonstrates a technique for identifying cement channels. Logs from Nigeria comparing oil saturation estimates before and after a squeeze operation illustrate the effect of casing fluid flushing of the formation through open perforations. Understanding the diagnostic character of these curves leads to higher confidence in the overall log interpretation process.

  2. Log-Tool

    SciTech Connect

    Goodall, John

    2012-05-21

    Log files are typically semi- or un-structured. To be useable for visualization and machine learning, they need to be parsed into a standard, structured format. Log-tool is a tool for facilitating the parsing, structuring, and routing of log files (e.g. intrusion detection long, web server logs, system logs). It consists of three main components: (1) Input – it will input data from files, standard input, and syslog, (2) Parser – it will parse the log file based on regular expressions into structured data (JSNO format), (3) Output – it will output structured data into commonly used formats, including Redis (a database), standard output, and syslog.

  3. Cochlear implantation in a patient with grand mal epilepsy.

    PubMed

    Szilvassy, J; Czigner, J; Somogyi, I; Jori, J; Kiss, J G; Szilvassy, Z

    1998-06-01

    A case is reported in which a Nucleus 22 channel intracochlear implant was used to treat a deaf Hungarian woman (aged 37 years) with a 34-year history of grand mal (GM) epilepsy maintained on carbamazepine-diazepam combination therapy who had not benefited from conventional hearing aids. Pre-operative electrical stimulation of the acoustic nerve, however, exhibited a good nerve function with no evidence of abnormal waveforms in the electroencephalogram (EEG). Successful intracochlear insertion of the 22 electrode resulted in a 40 dB hearing improvement at frequencies 250-2000 Hz in the implanted ear with no signs of pathologic wave activity at either the previously recognized epileptic focus (fronto-precentral region) or indeed, in other regions of the brain at use of the implant. We conclude that intracochlear implantation per se is not a hazardous intervention in patients with fronto-precentral epileptic foci. PMID:9764299

  4. LogScope

    NASA Technical Reports Server (NTRS)

    Havelund, Klaus; Smith, Margaret H.; Barringer, Howard; Groce, Alex

    2012-01-01

    LogScope is a software package for analyzing log files. The intended use is for offline post-processing of such logs, after the execution of the system under test. LogScope can, however, in principle, also be used to monitor systems online during their execution. Logs are checked against requirements formulated as monitors expressed in a rule-based specification language. This language has similarities to a state machine language, but is more expressive, for example, in its handling of data parameters. The specification language is user friendly, simple, and yet expressive enough for many practical scenarios. The LogScope software was initially developed to specifically assist in testing JPL s Mars Science Laboratory (MSL) flight software, but it is very generic in nature and can be applied to any application that produces some form of logging information (which almost any software does).

  5. Evaluation of the use of empirical ambient ozone pollutant modeling and subject activity logs as an indirect measurement of ozone exposure

    SciTech Connect

    Hopkins, L.P.; Fraser, M.P.; Ensor, K.B.; Rifai, H.S.

    1998-12-31

    The personal ozone exposure of women on the track team at Rice University was monitored using Harvard passive samplers over a period of six weeks during August and September of 1997. Each subject logged their location and activity in and around campus during the exposure period. A three-dimensional kriging model of ozone was developed to estimate the ozone exposure for each subject from ambient fixed site monitoring data. The ozone predictions from the model were combined with the activity and location information, adjusted for indoor environment when applicable, to estimate personal exposure concentrations for each subject. Using two independent approaches, the kriging model was proven to provide accurate spatial and temporal estimates of ozone at subject exposure points. The results from this work show that the method developed to estimate exposure through kriging over (x,y,t) to predict ozone concentrations at exposure points combined with subject activity/time logs produces exposure estimates within the error bounds of the analytical methods for personal monitoring.

  6. A Universal Logging System for LHCb Online

    NASA Astrophysics Data System (ADS)

    Nikolaidis, Fotis; Brarda, Loic; Garnier, Jean-Christophe; Neufeld, Niko

    2011-12-01

    A log is recording of system's activity, aimed to help system administrator to traceback an attack, find the causes of a malfunction and generally with troubleshooting. The fact that logs are the only information an administrator may have for an incident, makes logging system a crucial part of an IT infrastructure. In large scale infrastructures, such as LHCb Online, where quite a few GB of logs are produced daily, it is impossible for a human to review all of these logs. Moreover, a great percentage of them as just "noise". That makes clear that a more automated and sophisticated approach is needed. In this paper, we present a low-cost centralized logging system which allow us to do in-depth analysis of every log.

  7. Recovery Efficiency Test Project: Phase 1, Activity report. Volume 1: Site selection, drill plan preparation, drilling, logging, and coring operations

    SciTech Connect

    Overbey, W.K. Jr.; Carden, R.S.; Kirr, J.N.

    1987-04-01

    The recovery Efficiency Test well project addressed a number of technical issues. The primary objective was to determine the increased efficiency gas recovery of a long horizontal wellbore over that of a vertical wellbore and, more specifically, what improvements can be expected from inducing multiple hydraulic fractures from such a wellbore. BDM corporation located, planned, and drilled a long radius turn horizontal well in the Devonian shale Lower Huron section in Wayne County, West Virginia, demonstrating that state-of-the-art technology is capable of drilling such wells. BDM successfully tested drilling, coring, and logging in a horizontal well using air as the circulating medium; conducted reservoir modeling studies to protect flow rates and reserves in advance of drilling operations; observed two phase flow conditions in the wellbore not observed previously; cored a fracture zone which produced gas; observed that fractures in the core and the wellbore were not systematically spaced (varied from 5 to 68 feet in different parts of the wellbore); observed that highest gas show rates reported by the mud logger corresponded to zone with lowest fracture spacing (five feet) or high fracture frequency. Four and one-half inch casting was successfully installed in the borehole and was equipped to isolate the horizontal section into eight (8) zones for future testing and stimulation operations. 6 refs., 48 figs., 10 tabs.

  8. malB Region in Escherichia coli K-12: Characterization of New Mutations

    PubMed Central

    Hofnung, Maurice; Hatfield, Dolph; Schwartz, Maxime

    1974-01-01

    Phenotypic characterization and mapping of more than 50 Mal− mutations located in the malB region lead one to divide the site for Mal−λs mutations (formerly called gene malB) in that region, into two adjacent genetic segments malJ and malK. malJ and malK are both involved in maltose permeation. It is suggested that (i) malK and lamB, the only known gene specifically involved in phage λ adsorption (20), constitute an operon of polarity malK lamB. (ii) malJ and malK correspond to two different genes, and (iii) a promoter for the malK lamB operon is located between malJ and malK. Since λ receptors and maltose permease are inducible by maltose and absent in malT mutants, it is likely that the expression of the malK lamB operon is controlled by the product of gene malT, the positive regulatory gene of the maltose system. PMID:4587612

  9. Learning new tricks from an old dog: MalT of the Escherichia coli maltose system is part of a complex regulatory network.

    PubMed

    Boos, W; Böhm, A

    2000-09-01

    The regulation of the maltose system in Escherichia coli has traditionally been viewed as a simple positive feedback loop. Today, we know that there are cross connections to several, seemingly unrelated, metabolic pathways. MalT, the central activator of the mal genes, is the key element in this complex regulatory network and integrates the different signals to give an appropriate transcriptional response. PMID:10973069

  10. Well Log ETL tool

    2013-08-01

    This is an executable python script which offers two different conversions for well log data: 1) Conversion from a BoreholeLASLogData.xls model to a LAS version 2.0 formatted XML file. 2) Conversion from a LAS 2.0 formatted XML file to an entry in the WellLog Content Model. Example templates for BoreholeLASLogData.xls and WellLogsTemplate.xls can be found in the package after download.

  11. Leu343Phe substitution in the Malx3 protein of Saccharomyces cerevisiae increases the constitutivity and glucose insensitivity of MAL gene expression.

    PubMed

    Higgins, V J; Braidwood, M; Bissinger, P; Dawes, I W; Attfield, P V

    1999-06-01

    To utilise maltose as a carbon source Saccharomyces cerevisiae needs one or more functional MAL loci that contain the MALx1 gene encoding maltose permease, MALx2 encoding maltase, and MALx3 encoding a transcriptional activator. Maltose causes a rapid MALx3-dependent induction of MAL gene transcription, and glucose represses this activation via Mig1p. A MALx3 gene conveying high MAL gene expression in the absence of maltose in a malx3 laboratory mutant strain has been isolated from baker's yeast. The construction of hybrid genes between the isolated gene and a highly regulated MALx3 gene showed that constitutivity was the result of multiple amino-acid alterations throughout the structural gene. The combined effect of these amino-acid alterations was shown to be stronger than the sum of their individual effects on constitutivity. Analysis in glucose-repressed conditions confirmed that increased MALx3 transcript levels increased the glucose insensitivity of MAL gene expression but did not affect constitutivity. Analysis of four mutations between aa 343 and 375, lying within a proposed negative regulatory domain, showed that the single mutation of Leu343Phe increased the glucose insensitivity of MAL gene expression by 30-fold. These results demonstrate that not only Mig1p modulation of MALx3 expression, but also the MALx3 protein structure, is involved in the glucose-insensitive expression of the MAL genes. PMID:10369955

  12. Log-Tool

    2012-05-21

    Log files are typically semi- or un-structured. To be useable for visualization and machine learning, they need to be parsed into a standard, structured format. Log-tool is a tool for facilitating the parsing, structuring, and routing of log files (e.g. intrusion detection long, web server logs, system logs). It consists of three main components: (1) Input – it will input data from files, standard input, and syslog, (2) Parser – it will parse the logmore » file based on regular expressions into structured data (JSNO format), (3) Output – it will output structured data into commonly used formats, including Redis (a database), standard output, and syslog.« less

  13. Selective logging and its relation to deforestation

    NASA Astrophysics Data System (ADS)

    Asner, Gregory P.; Keller, Michael; Lentini, Marco; Merry, Frank; Souza, Carlos, Jr.

    Selective logging is a major contributor to the social, economic, and ecological dynamics of Brazilian Amazonia. Logging activities have expanded from low-volume floodplain harvests in past centuries to high-volume operations today that take about 25 million m3 of wood from the forest each year. The most common highimpact conventional and often illegal logging practices result in major collateral forest damage, with cascading effects on ecosystem processes. Initial carbon losses and forest recovery rates following timber harvest are tightly linked to initial logging intensity, which drives changes in forest gap fraction, fragmentation, and the light environment. Other ecological processes affected by selective logging include nutrient cycling, hydrological function, and postharvest disturbance such as fire. This chapter synthesizes the ecological impacts of selective logging, in the context of the recent socioeconomic conditions throughout Brazilian Amazonia, as determined from field-based and remote sensing studies carried out during the Large-Scale Biosphere-Atmosphere Experiment in Amazonia program.

  14. A Burkholderia thailandensis Acyl-Homoserine Lactone-Independent Orphan LuxR Homolog That Activates Production of the Cytotoxin Malleilactone

    PubMed Central

    Truong, Thao T.; Seyedsayamdost, Mohammad; Greenberg, E. Peter

    2015-01-01

    ABSTRACT Burkholderia thailandensis has three acyl-homoserine lactone (AHL) LuxR-LuxI quorum-sensing circuits and two orphan LuxR homologs. Orphans are LuxR-type transcription factors that do not have cognate LuxI-type AHL synthases. One of the orphans, MalR, is genetically linked to the mal gene cluster, which encodes enzymes required for production of the cytotoxic polyketide malleilactone. Under normal laboratory conditions the mal gene cluster is silent; however, antibiotics like trimethoprim induce mal transcription. We show that trimethoprim-dependent induction of the mal genes requires MalR. MalR has all of the conserved amino acid residues characteristic of AHL-responsive LuxR homologs, but in B. thailandensis, MalR activation of malleilactone synthesis genes is not responsive to AHLs. MalR can activate transcription from the mal promoter in E. coli without addition of AHLs or trimethoprim. Expression of malR in B. thailandensis is induced by trimethoprim. Our data indicate that MalR binds to a lux box-like element in the mal promoter and activates transcription of the mal genes in an AHL-independent manner. Antibiotics like trimethoprim appear to activate mal gene expression indirectly by somehow activating malR expression. MalR activation of the mal genes represents an example of a LuxR homolog that is not a receptor for an AHL quorum-sensing signal. Our evidence is consistent with the idea that mal gene activation depends solely on sufficient transcription of the malR gene. IMPORTANCE LuxR proteins are transcription factors that are typically activated by acyl-homoserine lactone (AHL) signals. We demonstrate that a conserved LuxR family protein, MalR, activates genes independently of AHLs. MalR is required for transcription of genes coding for synthesis of the cytotoxic polyketide malleilactone. These genes are not expressed when cells are grown under normal laboratory conditions. In laboratory culture, MalR induction of malleilactone requires certain

  15. 47 CFR 73.1820 - Station log.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... part. (iii) An entry of each test and activation of the Emergency Alert System (EAS) pursuant to the requirement of part 11 of this chapter and the EAS Operating Handbook. Stations may keep EAS data in a special EAS log which shall be maintained at a convenient location; however, this log is considered a part...

  16. 47 CFR 73.1820 - Station log.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... part. (iii) An entry of each test and activation of the Emergency Alert System (EAS) pursuant to the requirement of part 11 of this chapter and the EAS Operating Handbook. Stations may keep EAS data in a special EAS log which shall be maintained at a convenient location; however, this log is considered a part...

  17. 47 CFR 73.1820 - Station log.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... part. (iii) An entry of each test and activation of the Emergency Alert System (EAS) pursuant to the requirement of part 11 of this chapter and the EAS Operating Handbook. Stations may keep EAS data in a special EAS log which shall be maintained at a convenient location; however, this log is considered a part...

  18. 47 CFR 73.1820 - Station log.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... part. (iii) An entry of each test and activation of the Emergency Alert System (EAS) pursuant to the requirement of part 11 of this chapter and the EAS Operating Handbook. Stations may keep EAS data in a special EAS log which shall be maintained at a convenient location; however, this log is considered a part...

  19. 47 CFR 73.1820 - Station log.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... part. (iii) An entry of each test and activation of the Emergency Alert System (EAS) pursuant to the requirement of part 11 of this chapter and the EAS Operating Handbook. Stations may keep EAS data in a special EAS log which shall be maintained at a convenient location; however, this log is considered a part...

  20. Structural basis for cytokinin production by LOG from Corynebacterium glutamicum.

    PubMed

    Seo, Hogyun; Kim, Sangwoo; Sagong, Hye-Young; Son, Hyeoncheol Francis; Jin, Kyeong Sik; Kim, Il-Kwon; Kim, Kyung-Jin

    2016-01-01

    "Lonely guy" (LOG) has been identified as a cytokinin-producing enzyme in plants and plant-interacting fungi. The gene product of Cg2612 from the soil-dwelling bacterium Corynebacterium glutamicum was annotated as an LDC. However, the facts that C. glutamicum lacks an LDC and Cg2612 has high amino acid similarity with LOG proteins suggest that Cg2612 is possibly an LOG protein. To investigate the function of Cg2612, we determined its crystal structure at a resolution of 2.3 Å. Cg2612 functions as a dimer and shows an overall structure similar to other known LOGs, such as LOGs from Arabidopsis thaliana (AtLOG), Claviceps purpurea (CpLOG), and Mycobacterium marinum (MmLOG). Cg2612 also contains a "PGGXGTXXE" motif that contributes to the formation of an active site similar to other LOGs. Moreover, biochemical studies on Cg2612 revealed that the protein has phosphoribohydrolase activity but not LDC activity. Based on these structural and biochemical studies, we propose that Cg2612 is not an LDC family enzyme, but instead belongs to the LOG family. In addition, the prenyl-binding site of Cg2612 (CgLOG) comprised residues identical to those seen in AtLOG and CpLOG, albeit dissimilar to those in MmLOG. The work provides structural and functional implications for LOG-like proteins from other microorganisms. PMID:27507425

  1. Structural basis for cytokinin production by LOG from Corynebacterium glutamicum

    PubMed Central

    Seo, Hogyun; Kim, Sangwoo; Sagong, Hye-Young; Son, Hyeoncheol Francis; Jin, Kyeong Sik; Kim, Il-Kwon; Kim, Kyung-Jin

    2016-01-01

    “Lonely guy” (LOG) has been identified as a cytokinin-producing enzyme in plants and plant-interacting fungi. The gene product of Cg2612 from the soil-dwelling bacterium Corynebacterium glutamicum was annotated as an LDC. However, the facts that C. glutamicum lacks an LDC and Cg2612 has high amino acid similarity with LOG proteins suggest that Cg2612 is possibly an LOG protein. To investigate the function of Cg2612, we determined its crystal structure at a resolution of 2.3 Å. Cg2612 functions as a dimer and shows an overall structure similar to other known LOGs, such as LOGs from Arabidopsis thaliana (AtLOG), Claviceps purpurea (CpLOG), and Mycobacterium marinum (MmLOG). Cg2612 also contains a “PGGXGTXXE” motif that contributes to the formation of an active site similar to other LOGs. Moreover, biochemical studies on Cg2612 revealed that the protein has phosphoribohydrolase activity but not LDC activity. Based on these structural and biochemical studies, we propose that Cg2612 is not an LDC family enzyme, but instead belongs to the LOG family. In addition, the prenyl-binding site of Cg2612 (CgLOG) comprised residues identical to those seen in AtLOG and CpLOG, albeit dissimilar to those in MmLOG. The work provides structural and functional implications for LOG-like proteins from other microorganisms. PMID:27507425

  2. Overexpression of Mal61p in Saccharomyces cerevisiae and characterization of maltose transport in artificial membranes.

    PubMed

    van der Rest, M E; de Vries, Y; Poolman, B; Konings, W N

    1995-10-01

    For maltose uptake in Saccharomyces cerevisiae, multiple kinetic forms of transport as well as inhibition of transport by high concentrations of maltose at the trans side of the plasma membrane have been described. Most of these studies were hampered by a lack of genetically well-defined mutants and/or the lack of an artificial membrane system to study translocation catalysis in vitro. A genetically well-defined S. cerevisiae strain lacking the various MAL loci was constructed by gene disruption. Expression of the maltose transport protein (Mal61p) was studied by using various plasmid vectors that differed in copy number and/or type of promoter. The expression levels were quantitated by immunoblotting with antibodies generated against the N-terminal half of Mal61p. The levels of expression as well as the initial uptake rates were increased 20-fold compared with those in a yeast strain carrying only one chromosomal MAL locus. Similar results were obtained when the transport activities were compared in hybrid membranes of the corresponding strains. To generate a proton motive force, isolated membranes were fused with liposomes containing cytochrome c oxidase as a proton pump. Fusion was achieved by a cycle of freeze-thawing, after which the hybrid membranes were passed through a filter with a defined pore size to obtain unilamellar membrane vesicles. Proton motive force-driven maltose uptake, maltose efflux down the concentration gradient, and equilibrium exchange of maltose in the hybrid membranes vesicles have been analyzed. The data indicate that maltose transport by the maltose transporter is kinetically monophasic and fully reversible under all conditions tested. PMID:7559327

  3. Overexpression of Mal61p in Saccharomyces cerevisiae and characterization of maltose transport in artificial membranes.

    PubMed Central

    van der Rest, M E; de Vries, Y; Poolman, B; Konings, W N

    1995-01-01

    For maltose uptake in Saccharomyces cerevisiae, multiple kinetic forms of transport as well as inhibition of transport by high concentrations of maltose at the trans side of the plasma membrane have been described. Most of these studies were hampered by a lack of genetically well-defined mutants and/or the lack of an artificial membrane system to study translocation catalysis in vitro. A genetically well-defined S. cerevisiae strain lacking the various MAL loci was constructed by gene disruption. Expression of the maltose transport protein (Mal61p) was studied by using various plasmid vectors that differed in copy number and/or type of promoter. The expression levels were quantitated by immunoblotting with antibodies generated against the N-terminal half of Mal61p. The levels of expression as well as the initial uptake rates were increased 20-fold compared with those in a yeast strain carrying only one chromosomal MAL locus. Similar results were obtained when the transport activities were compared in hybrid membranes of the corresponding strains. To generate a proton motive force, isolated membranes were fused with liposomes containing cytochrome c oxidase as a proton pump. Fusion was achieved by a cycle of freeze-thawing, after which the hybrid membranes were passed through a filter with a defined pore size to obtain unilamellar membrane vesicles. Proton motive force-driven maltose uptake, maltose efflux down the concentration gradient, and equilibrium exchange of maltose in the hybrid membranes vesicles have been analyzed. The data indicate that maltose transport by the maltose transporter is kinetically monophasic and fully reversible under all conditions tested. PMID:7559327

  4. Can we use digital life-log images to investigate active and sedentary travel behaviour? Results from a pilot study

    PubMed Central

    2011-01-01

    Background Active travel such as walking and cycling has potential to increase physical activity levels in sedentary individuals. Motorised car travel is a sedentary behaviour that contributes to carbon emissions. There have been recent calls for technology that will improve our ability to measure these travel behaviours, and in particular evaluate modes and volumes of active versus sedentary travel. The purpose of this pilot study is to investigate the potential efficacy of a new electronic measurement device, a wearable digital camera called SenseCam, in travel research. Methods Participants (n = 20) were required to wear the SenseCam device for one full day of travel. The device automatically records approximately 3,600 time-stamped, first-person point-of-view images per day, without any action required by the wearer. Participants also completed a self-report travel diary over the same period for comparison, and were interviewed afterwards to assess user burden and experience. Results There were a total of 105 confirmed journeys in this pilot. The new SenseCam device recorded more journeys than the travel diary (99 vs. 94). Although the two measures demonstrated an acceptable correlation for journey duration (r = 0.92, p < 0.001) self-reported journey duration was over-reported (mean difference 154 s per journey; 95% CI = 89 to 218 s; 95% limits of agreement = 154 ± 598 s (-444 to 752 s)). The device also provided visual data that was used for directed interviews about sources of error. Conclusions Direct observation of travel behaviour from time-stamped images shows considerable potential in the field of travel research. Journey duration derived from direct observation of travel behaviour from time-stamped images appears to suggest over-reporting of self-reported journey duration. PMID:21599935

  5. MalI, a novel protein involved in regulation of the maltose system of Escherichia coli, is highly homologous to the repressor proteins GalR, CytR, and LacI.

    PubMed

    Reidl, J; Römisch, K; Ehrmann, M; Boos, W

    1989-09-01

    The maltose regulon of Escherichia coli comprises several operons that are under common regulatory control of the MalT activator protein. Five mal genes, organized in two divergent operons, code for a binding-protein-dependent transport system specific for maltose and maltodextrins. MalK, one of the subunits of this transport system, not only is essential for transport but also plays a role in regulation. Mutations abolishing MalK function not only result in inability to transport maltose but also cause constitutive expression of the maltose regulon. For this constitutivity to be exerted, the function of an additional gene product, MalI, is necessary. Using the constitutive expression of a malK-lacZ fusion as a signal, we cloned the malI gene, expressed it in minicells, and determined its DNA sequence. The sequence predicted a protein of 34,729 molecular weight, in agreement with the apparent molecular weight of the protein (35,000) when expressed in minicells and analyzed by polyacrylamide gel electrophoresis and autoradiography. MalI exhibited high homology to the repressor proteins GalR, CytR, and LacI. When the amino acid sequences were appropriately aligned, MalI showed 28% identity to GalR, 21% to CytR, and 24% to LacI. Including conservative amino acid exchanges, these numbers increased to 69, 56, and 58%, respectively. The regions of high homology were clustered in particular at the N-terminal portion of the protein that includes the helix-turn-helix motif thought to be involved in DNA binding. The protein contained a short stretch of 30 amino acids that was surprisingly homologous to a sequence in MalT. The amino-terminal half of the protein exhibited significant homology with MalK. The transcriptional start of malI was determined by reverse transcriptase and by S1 nuclease mapping. We found a possible binding site for cyclic AMP receptor protein in the promoter region of malI as well as two perfect direct repeats of 14 base pairs with twofold symmetry

  6. Stress Response and Perinatal Reprogramming: Unraveling (Mal)adaptive Strategies.

    PubMed

    Musazzi, Laura; Marrocco, Jordan

    2016-01-01

    Environmental stressors induce coping strategies in the majority of individuals. The stress response, involving the activation of the hypothalamic-pituitary-adrenocortical axis and the consequent release of corticosteroid hormones, is indeed aimed at promoting metabolic, functional, and behavioral adaptations. However, behavioral stress is also associated with fast and long-lasting neurochemical, structural, and behavioral changes, leading to long-term remodeling of glutamate transmission, and increased susceptibility to neuropsychiatric disorders. Of note, early-life events, both in utero and during the early postnatal life, trigger reprogramming of the stress response, which is often associated with loss of stress resilience and ensuing neurobehavioral (mal)adaptations. Indeed, adverse experiences in early life are known to induce long-term stress-related neuropsychiatric disorders in vulnerable individuals. Here, we discuss recent findings about stress remodeling of excitatory neurotransmission and brain morphology in animal models of behavioral stress. These changes are likely driven by epigenetic factors that lie at the core of the stress-response reprogramming in individuals with a history of perinatal stress. We propose that reprogramming mechanisms may underlie the reorganization of excitatory neurotransmission in the short- and long-term response to stressful stimuli. PMID:27057367

  7. Stress Response and Perinatal Reprogramming: Unraveling (Mal)adaptive Strategies

    PubMed Central

    Musazzi, Laura; Marrocco, Jordan

    2016-01-01

    Environmental stressors induce coping strategies in the majority of individuals. The stress response, involving the activation of the hypothalamic-pituitary-adrenocortical axis and the consequent release of corticosteroid hormones, is indeed aimed at promoting metabolic, functional, and behavioral adaptations. However, behavioral stress is also associated with fast and long-lasting neurochemical, structural, and behavioral changes, leading to long-term remodeling of glutamate transmission, and increased susceptibility to neuropsychiatric disorders. Of note, early-life events, both in utero and during the early postnatal life, trigger reprogramming of the stress response, which is often associated with loss of stress resilience and ensuing neurobehavioral (mal)adaptations. Indeed, adverse experiences in early life are known to induce long-term stress-related neuropsychiatric disorders in vulnerable individuals. Here, we discuss recent findings about stress remodeling of excitatory neurotransmission and brain morphology in animal models of behavioral stress. These changes are likely driven by epigenetic factors that lie at the core of the stress-response reprogramming in individuals with a history of perinatal stress. We propose that reprogramming mechanisms may underlie the reorganization of excitatory neurotransmission in the short- and long-term response to stressful stimuli. PMID:27057367

  8. 6. Log calving barn. Interior view showing log postandbeam support ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Log calving barn. Interior view showing log post-and-beam support system and animal stalls. - William & Lucina Bowe Ranch, Log Calving Barn, 230 feet south-southwest of House, Melrose, Silver Bow County, MT

  9. EE-3A Logging Report

    SciTech Connect

    Anderson, David W.

    1993-12-15

    Two logs of EE-3A were performed during the last couple of weeks. The first of which, was a Temperature/Casing-Collar Locator (CCL) log, which took place on Friday, December 10th., 1993. The second log was a Caliper log which was done in cooperation with the Dia-Log Company, of Odessa, TX. on Monday, December, 13th., 1993.

  10. Proof of Concept of the Core Parameter Service Using the CCSDS SM&C MAL Service

    NASA Astrophysics Data System (ADS)

    Poupart, E.; Steere, S.; Coccoluto, F.; Feliot, D.

    2009-05-01

    Within the context of the Spacecraft Monitoring & Control (SM&C) work group of the Consultative Committee for Space Data Systems (CCSDS), which sees the active participation of 10 space agencies and of the Space Domain Task Force of the Object Management Group (OMG), a service oriented architecture is being defined consisting of a set of standard end-to-end services between functions based on the ground or on-board a spacecraft, that are responsible for mission operations. A specification for the layering service has been agreed upon (see [1], [2], [3], [4]) between the involved space agencies to achieve interoperability at the service level. Mission operation services sit upon a Message Abstract Layer (MAL) which is transport agnostic (see [4]). the CCSDS Message Abstraction Layer (MAL) provides message abstraction and generic service patterns to the Mission Operation Services defined in [1]. The three layers of the Mission Operations Service Framework [1] are The Mission Operations (MO) Layer, The Common Services Layer, and the Message Abstraction Layer (MAL). The CNES has decided to study the implementation of this service oriented architecture on one of its Monitoring & Control applications, called OCTAVE, using the Message Oriented Middleware JORAM. Many Questions arise when trying to migrate existing Monitoring & Control applications towards this standard: Questions concerning the SM&c Standard: Is it possible to have a satifying operational implementation? Is there an over cost due to the richness of data structures? Is the standard complete enough to be used by a project? Questions concerning migration: Is it feasible to migrate the CNES legacy Monitoring & Control System (MCS) "OCTAVE" and if yes how? External Adapters? Internal Adapters? Native SM&C? Is it possible to reduce the impact on our existing legacy application? How to keep existing additional functionalities not covered by SM&C? MAL implementation questions: Is the CNES MAL/Joram reference

  11. Mal de Meleda with Congenital Cataract: A Novel Case Report.

    PubMed

    Sethi, Anisha; Janda, Jaspreet Kaur; Sharma, Nidhi; Malhotra, S K

    2015-01-01

    Mal de meleda (MdM), a rare autosomal recessive genodermatosis is characterized by erythema and hyperkeratosis of the palms and soles with a sharp demarcation and that progress with age (progrediens) and extend to the dorsal aspects of the hands and feet (transgrediens). It has been associated with various conditions albeit rarely with congenial cataract. Ocular lens and the skin have the same embryological origins. We hereby present this novel case report of Mal de meleda in association with congenital posterior subcapsular cataract which to the best of our knowledge has not been reported from India before. PMID:26538740

  12. Microbiologic Methods Utilized in the MAL-ED Cohort Study

    PubMed Central

    Houpt, Eric; Gratz, Jean; Kosek, Margaret; Zaidi, Anita K. M.; Qureshi, Shahida; Kang, Gagandeep; Babji, Sudhir; Mason, Carl; Bodhidatta, Ladaporn; Samie, Amidou; Bessong, Pascal; Barrett, Leah; Lima, Aldo; Havt, Alexandre; Haque, Rashidul; Mondal, Dinesh; Taniuchi, Mami; Stroup, Suzanne; McGrath, Monica; Lang, Dennis

    2014-01-01

    A central hypothesis of The Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) study is that enteropathogens contribute to growth faltering. To examine this question, the MAL-ED network of investigators set out to achieve 3 goals: (1) develop harmonized protocols to test for a diverse range of enteropathogens, (2) provide quality-assured and comparable results from 8 global sites, and (3) achieve maximum laboratory throughput and minimum cost. This paper describes the rationale for the microbiologic assays chosen and methodologies used to accomplish the 3 goals. PMID:25305291

  13. 4. Log chicken house (far left foreground), log bunkhouse (far ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Log chicken house (far left foreground), log bunkhouse (far left background), one-room log cabin (left of center background), log root cellar (center), post-and-beam center in foreground, and blacksmith shop (far right foreground). View to southeast. - William & Lucina Bowe Ranch, County Road 44, 0.1 mile northeast of Big Hole River Bridge, Melrose, Silver Bow County, MT

  14. Reconsidering Data Logging in Light of Digital Forensics

    NASA Astrophysics Data System (ADS)

    Chou, Bin-Hui; Takahashi, Kenichi; Hori, Yoshiaki; Sakurai, Kouichi

    Logs record the events that have happened within in a system so they are considered the history of system activities. They are one of the objects that digital forensic investigators would like to examine when a security incident happens. However, logs were initially created for trouble shooting, and are not purposefully designed for digital forensics. Thus, enormous and redundant log data make analysis tasks complicated and time-consuming to find valuable information, and make logging-related techniques difficult utilized in some systems such as embedded systems. In this paper, we reconsider a data logging mechanism in terms of forensics and consequently, we propose purpose-based forensic logging. In purpose-based forensic logging, we only collect the required logs according to a specific purpose, which could decrease the space that logs occupy and may mitigate the analysis tasks during forensic investigations.

  15. Neutron logging tool

    SciTech Connect

    Taylor, J.A.; Taylor, K.G.

    1987-02-03

    A method is described of logging earth formations traversed by a well bore and utilizing a logging tool having a neutron source and a short spaced and a long spaced thermal neutron detector which produce an independent response as a function of depth of the logging tool in a well bore. The method comprises: moving the logging tool through a well bore to locate a section of the earth formations which has minimum porosity and obtaining measurement responses from each of the long and short spaced detectors; normalizing the responses of the long and short spaced detectors by matching the sensitivity of response of the long spaced detector to the sensitivity of response of the short spaced detector for an earth formation which has minimum porosity so that the normalized responses track one another in an earth formation which has minimum porosity; and moving the tool over the length of the well bore to be surveyed while recording the normalized responses of the long and short spaced neutron detectors as a function of depth.

  16. Logging on to Learn

    ERIC Educational Resources Information Center

    Butler, Kevin

    2010-01-01

    A classroom lecture at Capistrano Connections Academy in Southern California involves booting up the home computer, logging on to a Web site, and observing a teacher conducting a PowerPoint presentation of that day's lesson entirely online. Through microphone headsets, students can watch on their home computers, respond to the teacher's questions,…

  17. Interactive Reflective Logs

    ERIC Educational Resources Information Center

    Deaton, Cynthia Minchew; Deaton, Benjamin E.; Leland, Katina

    2010-01-01

    The authors created an interactive reflective log (IRL) to provide teachers with an opportunity to use a journal approach to record, evaluate, and communicate student understanding of science concepts. Unlike a traditional journal, the IRL incorporates prompts to encourage students to discuss their understanding of science content and science…

  18. Logs Perl Module

    2007-04-04

    A perl module designed to read and parse the voluminous set of event or accounting log files produced by a Portable Batch System (PBS) server. This module can filter on date-time and/or record type. The data can be returned in a variety of formats.

  19. Log of Apollo 11.

    ERIC Educational Resources Information Center

    National Aeronautics and Space Administration, Washington, DC.

    The major events of the first manned moon landing mission, Apollo 11, are presented in chronological order from launch time until arrival of the astronauts aboard the U.S.S. Hornet. The log is descriptive, non-technical, and includes numerous color photographs of the astronauts on the moon. (PR)

  20. 7 CFR 1421.417 - Disbursing MAL and LDP proceeds.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... COMMODITIES-MARKETING ASSISTANCE LOANS AND LOAN DEFICIENCY PAYMENTS FOR 2008 THROUGH 2012 Designated Marketing... producer within 3 work days from the date the DMA receives MAL or LDP proceeds from CCC, after deduction of... distributed to the producer within 3 days of the completion of the application. (d) The DMA shall...

  1. 7 CFR 1421.417 - Disbursing MAL and LDP proceeds.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... COMMODITIES-MARKETING ASSISTANCE LOANS AND LOAN DEFICIENCY PAYMENTS FOR 2008 THROUGH 2012 Designated Marketing... producer within 3 work days from the date the DMA receives MAL or LDP proceeds from CCC, after deduction of... distributed to the producer within 3 days of the completion of the application. (d) The DMA shall...

  2. Log-Concavity and Strong Log-Concavity: a review

    PubMed Central

    Saumard, Adrien; Wellner, Jon A.

    2016-01-01

    We review and formulate results concerning log-concavity and strong-log-concavity in both discrete and continuous settings. We show how preservation of log-concavity and strongly log-concavity on ℝ under convolution follows from a fundamental monotonicity result of Efron (1969). We provide a new proof of Efron's theorem using the recent asymmetric Brascamp-Lieb inequality due to Otto and Menz (2013). Along the way we review connections between log-concavity and other areas of mathematics and statistics, including concentration of measure, log-Sobolev inequalities, convex geometry, MCMC algorithms, Laplace approximations, and machine learning. PMID:27134693

  3. Mal3 masks catastrophe events in Schizosaccharomyces pombe microtubules by inhibiting shrinkage and promoting rescue.

    PubMed

    Katsuki, Miho; Drummond, Douglas R; Osei, Michael; Cross, Robert A

    2009-10-23

    Schizosaccharomyces pombe Mal3 is a member of the EB family of proteins, which are proposed to be core elements in a tip-tracking network that regulates microtubule dynamics in cells. How Mal3 itself influences microtubule dynamics is unclear. We tested the effects of full-length recombinant Mal3 on dynamic microtubules assembled in vitro from purified S. pombe tubulin, using dark field video microscopy to avoid fluorescent tagging and data-averaging techniques to improve spatiotemporal resolution. We find that catastrophe occurs stochastically as a fast (<2.2 s) transition from constant speed growth to constant speed shrinkage with a constant probability that is independent of the Mal3 concentration. This implies that Mal3 neither stabilizes nor destabilizes microtubule tips. Mal3 does, however, stabilize the main part of the microtubule lattice, inhibiting shrinkage and increasing the frequency of rescues, consistent with recent models in which Mal3 on the lattice forms stabilizing lateral links between neighboring protofilaments. At high concentrations, Mal3 can entirely block shrinkage and induce very rapid rescue, making catastrophes impossible to detect, which may account for the apparent suppression of catastrophe by Mal3 and other EBs in vivo. Overall, we find that Mal3 stabilizes microtubules not by preventing catastrophe at the microtubule tip but by inhibiting lattice depolymerization and enhancing rescue. We argue that this implies that Mal3 binds microtubules in different modes at the tip and on the lattice. PMID:19740752

  4. Brucella TIR-like protein TcpB/Btp1 specifically targets the host adaptor protein MAL/TIRAP to promote infection.

    PubMed

    Li, Wenna; Ke, Yuehua; Wang, Yufei; Yang, Mingjuan; Gao, Junguang; Zhan, Shaoxia; Xinying, Du; Huang, Liuyu; Li, Wenfeng; Chen, Zeliang; Li, Juan

    2016-08-26

    Brucella spp. are known to avoid host immune recognition and weaken the immune response to infection. Brucella like accomplish this by employing two clever strategies, called the stealth strategy and hijacking strategy. The TIR domain-containing protein (TcpB/Btp1) of Brucella melitensis is thought to be involved in inhibiting host NF-κB activation by binding to adaptors downstream of Toll-like receptors. However, of the five TIR domain-containing adaptors conserved in mammals, whether MyD88 or MAL, even other three adaptors, are specifically targeted by TcpB has not been identified. Here, we confirmed the effect of TcpB on B.melitensis virulence in mice and found that TcpB selectively targets MAL. By using siRNA against MAL, we found that TcpB from B.melitensis is involved in intracellular survival and that MAL affects intracellular replication of B.melitensis. Our results confirm that TcpB specifically targets MAL/TIRAP to disrupt downstream signaling pathways and promote intra-host survival of Brucella spp. PMID:27311859

  5. Modelling pathogen log10 reduction values achieved by activated sludge treatment using naïve and semi naïve Bayes network models.

    PubMed

    Carvajal, Guido; Roser, David J; Sisson, Scott A; Keegan, Alexandra; Khan, Stuart J

    2015-11-15

    Risk management for wastewater treatment and reuse have led to growing interest in understanding and optimising pathogen reduction during biological treatment processes. However, modelling pathogen reduction is often limited by poor characterization of the relationships between variables and incomplete knowledge of removal mechanisms. The aim of this paper was to assess the applicability of Bayesian belief network models to represent associations between pathogen reduction, and operating conditions and monitoring parameters and predict AS performance. Naïve Bayes and semi-naïve Bayes networks were constructed from an activated sludge dataset including operating and monitoring parameters, and removal efficiencies for two pathogens (native Giardia lamblia and seeded Cryptosporidium parvum) and five native microbial indicators (F-RNA bacteriophage, Clostridium perfringens, Escherichia coli, coliforms and enterococci). First we defined the Bayesian network structures for the two pathogen log10 reduction values (LRVs) class nodes discretized into two states (< and ≥ 1 LRV) using two different learning algorithms. Eight metrics, such as Prediction Accuracy (PA) and Area Under the receiver operating Curve (AUC), provided a comparison of model prediction performance, certainty and goodness of fit. This comparison was used to select the optimum models. The optimum Tree Augmented naïve models predicted removal efficiency with high AUC when all system parameters were used simultaneously (AUCs for C. parvum and G. lamblia LRVs of 0.95 and 0.87 respectively). However, metrics for individual system parameters showed only the C. parvum model was reliable. By contrast individual parameters for G. lamblia LRV prediction typically obtained low AUC scores (AUC < 0.81). Useful predictors for C. parvum LRV included solids retention time, turbidity and total coliform LRV. The methodology developed appears applicable for predicting pathogen removal efficiency in water treatment

  6. Energy saving and endurance log for a log building

    SciTech Connect

    Dolata, G.

    1987-03-17

    A log is described for construction of a log building which comprises: an elongated peeled log of substantially uniform diameter along its length with parallel end faces, a bottom surface of the log having a concave surface configuration centered on a diametrical line of the log, a rounded top surface directly opposite from the concave bottom surface which mates with a concave surface of another log when placed upon the rounded top surface, a vertically extending longitudinal slot in the top surface of the log that extends the length of the log, a vertically extending longitudinal slot along at least one side of the log with the slot extending vertically substantially parallel with the diametrical line with the slot being formed outwardly of the concave surface, the log including at least one butt end, the butt end including an end slot along the diametrical line which extends from a top of the log down through the butt end to the concave surface; and the butt includes at least one short, longitudinally extending arcuate groove near an outer surface of the log which extends from a line juxtaposed the end slot down to at least one longitudinal slot in the log.

  7. Well logging system

    SciTech Connect

    Pitts, R.W.

    1980-02-19

    A well logging system includes a logging tool adapted to be passed through a borehole traversing an earth formation. The logging tool contains a sensor sensing a condition of the earth formation and providing electrical pulses corresponding in number and peak amplitude to the sensed condition. A first electrical pulse from the sensor occurring during each predetermined time period of a plurality of predetermined time periods, is stretched and then converted to parallel digital signals. A register receives the parallel digital signals and provides a serial digital signal in response to the shift pulses. A network provides an electrical synchronization pulse each time period prior to the occurrence of the shift pulses. A light emitting diode converts the synchronization pulses and the serial digital signals to corresponding light pulses. A cable including a fiber optic conductor transmits the light pulses uphole to the surface. Surface electronics includes a light-to-electrical converter for providing corresponding electrical pulses in accordance with the light pulses, so that the light-to-electrical converter provides a synchronization pulse followed by a serial digital signal each time period. Another circuit provides a set of shift pulses in response to the synchronizing pulse from the light-to-electrical converter, and an output circuit provides parallel output digital signals corresponding to the sensed condition in accordance with the shift pulses and the serial digital signals from the light-to -electrical converter.

  8. 2. Onroom log cabin (right), log root cellar (center), tworoom ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. On-room log cabin (right), log root cellar (center), two-room log cabin (left), and post-and-beam garage (background). View to southwest. - William & Lucina Bowe Ranch, County Road 44, 0.1 mile northeast of Big Hole River Bridge, Melrose, Silver Bow County, MT

  9. 12. Upstream view showing thelower log pond log chute in ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. Upstream view showing thelower log pond log chute in the main channel of the Hudson River. The log chute in the dam can be seen in the background. Facing southwest. - Glens Falls Dam, 100' to 450' West of U.S. Route 9 Bridge Spanning Hudson River, Glens Falls, Warren County, NY

  10. SedLog: A shareware program for drawing graphic logs and log data manipulation

    NASA Astrophysics Data System (ADS)

    Zervas, Dimitrios; Nichols, Gary J.; Hall, Robert; Smyth, Helen R.; Lüthje, Charlotta; Murtagh, Fionn

    2009-10-01

    SedLog is a free multi-platform software package for creating graphic sediment logs providing an intuitive graphical user interface. The graphic sediment logs generated by SedLog can be exported as PDF, Scalable Vector Graphics (SVG), or JPEG for use by other drawing applications or for publications. Log data can be imported and exported in Comma Separated Values (CSV) format. The logs can also be printed to any paper size the user wants. Zoom In, Zoom Out, Fit page, Fit Height and Fit Width facilities are also provided to enable the user to customise the workspace size.

  11. Continuous gravity gradient logging

    SciTech Connect

    Fitch, J.L.; Lyle, W.D. Jr.

    1986-07-29

    A method is described for conducting a gravimetry survey of an earth formation, comprising the steps of: (a) continuously traversing the earth formation with a gravity logging tool having a column of fluid within the tool, (b) measuring a first pressure difference along a first interval within the column of fluid, (c) measuring a second pressure difference along a second interval within the column of fluid, (d) differencing the first and second pressure differences to determine the gravity gradient along the earth formation between the first and second intervals.

  12. [Meleda disease (Mal de Meleda): historical shifts in perception].

    PubMed

    Gjurasić, Marija

    2010-01-01

    Nowadays, hereditary diseases are viewed through molecular mechanisms, and one of them, which keeps occurring rather frequently in medical publications, has been named after the Island of Mljet. The world first learned about mal de Meleda from a Dubrovnik physician Luka Stulli in 1826. He described it in a number of his island patients as a non-contagious hereditary skin disease, and named it mal de Meleda (a disease of Mljet). After Stulli, numerous scientists continued to investigate its aetiology and distinctive properties, introducing new scientific procedures to research the disease. The article keeps track of the way people and medicine perceived and treated mal de Meleda patients, starting from the early 19th century to the present day. It pays special attention to how the disease was perceived and described in medical literature through history. There are no reports in writing about the disease before the 19th century, but in oral tradition it was perceived as a punishment for the sins of sacrilege, sins of piracy, or even as leftovers of leprosy brought by the crusaders. We investigated if these legends have any support in preserved historical documents and to what extent they are related to real historical events and circumstances. Influenced by the booming research in microbiology, end 19th century physicians believed the disease was an isolated focus of leprosy. However, early 20th century physicians defined it as a hereditary skin disease with changes which distinguish it from other skin conditions. Genetic nature of the disease was later confirmed by molecular science. As for its geographical origin, the most recent medical research has shown that mal de Meleda is not restricted to the island of Mljet, and that it is spread worldwide, particularly in regions that, historically, were the trading routes of the Dubrovnik Republic. This implies that the mutation has spread through migration and persists only because it is not lethal and does not affect

  13. Grid Logging: Best Practices Guide

    SciTech Connect

    Tierney, Brian L; Tierney, Brian L; Gunter, Dan

    2008-04-01

    The purpose of this document is to help developers of Grid middleware and application software generate log files that will be useful to Grid administrators, users, developers and Grid middleware itself. Currently, most of the currently generated log files are only useful to the author of the program. Good logging practices are instrumental to performance analysis, problem diagnosis, and security auditing tasks such as incident tracing and damage assessment. This document does not discuss the issue of a logging API. It is assumed that a standard log API such as syslog (C), log4j (Java), or logger (Python) is being used. Other custom logging API or even printf could be used. The key point is that the logs must contain the required information in the required format. At a high level of abstraction, the best practices for Grid logging are: (1) Consistently structured, typed, log events; (2) A standard high-resolution timestamp; (3) Use of logging levels and categories to separate logs by detail and purpose; (4) Consistent use of global and local identifiers; and (5) Use of some regular, newline-delimited ASCII text format. The rest of this document describes each of these recommendations in detail.

  14. Weekly Log Record Sort (WLSORT).

    ERIC Educational Resources Information Center

    Foote, Thomas

    Computer routines to sort the weekly log records submitted by teachers participating in the Southwest Regional Laboratory's communications skills monitoring program are described. Written in Univac FORTRAN V, Weekly Log Record Sort (WLSORT) sorts log records on magnetic tape to enable subsequent computer programs to interpret the input data by…

  15. Assessment of Environmental Enteropathy in the MAL-ED Cohort Study: Theoretical and Analytic Framework

    PubMed Central

    Kosek, Margaret; Guerrant, Richard L.; Kang, Gagandeep; Bhutta, Zulfiqar; Yori, Pablo Peñataro; Gratz, Jean; Gottlieb, Michael; Lang, Dennis; Lee, Gwenyth; Haque, Rashidul; Mason, Carl J.; Ahmed, Tahmeed; Lima, Aldo; Petri, William A.; Houpt, Eric; Olortegui, Maribel Paredes; Seidman, Jessica C.; Mduma, Estomih; Samie, Amidou; Babji, Sudhir

    2014-01-01

    Individuals in the developing world live in conditions of intense exposure to enteric pathogens due to suboptimal water and sanitation. These environmental conditions lead to alterations in intestinal structure, function, and local and systemic immune activation that are collectively referred to as environmental enteropathy (EE). This condition, although poorly defined, is likely to be exacerbated by undernutrition as well as being responsible for permanent growth deficits acquired in early childhood, vaccine failure, and loss of human potential. This article addresses the underlying theoretical and analytical frameworks informing the methodology proposed by the Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) cohort study to define and quantify the burden of disease caused by EE within a multisite cohort. Additionally, we will discuss efforts to improve, standardize, and harmonize laboratory practices within the MAL-ED Network. These efforts will address current limitations in the understanding of EE and its burden on children in the developing world. PMID:25305293

  16. Assessment of environmental enteropathy in the MAL-ED cohort study: theoretical and analytic framework.

    PubMed

    Kosek, Margaret; Guerrant, Richard L; Kang, Gagandeep; Bhutta, Zulfiqar; Yori, Pablo Peñataro; Gratz, Jean; Gottlieb, Michael; Lang, Dennis; Lee, Gwenyth; Haque, Rashidul; Mason, Carl J; Ahmed, Tahmeed; Lima, Aldo; Petri, William A; Houpt, Eric; Olortegui, Maribel Paredes; Seidman, Jessica C; Mduma, Estomih; Samie, Amidou; Babji, Sudhir

    2014-11-01

    Individuals in the developing world live in conditions of intense exposure to enteric pathogens due to suboptimal water and sanitation. These environmental conditions lead to alterations in intestinal structure, function, and local and systemic immune activation that are collectively referred to as environmental enteropathy (EE). This condition, although poorly defined, is likely to be exacerbated by undernutrition as well as being responsible for permanent growth deficits acquired in early childhood, vaccine failure, and loss of human potential. This article addresses the underlying theoretical and analytical frameworks informing the methodology proposed by the Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) cohort study to define and quantify the burden of disease caused by EE within a multisite cohort. Additionally, we will discuss efforts to improve, standardize, and harmonize laboratory practices within the MAL-ED Network. These efforts will address current limitations in the understanding of EE and its burden on children in the developing world. PMID:25305293

  17. Engineered VEGF-releasing PEG-MAL hydrogel for pancreatic islet vascularization

    PubMed Central

    Phelps, Edward A.; Templeman, Kellie L.; Thulé, Peter M.; García, Andrés J.

    2013-01-01

    Biofunctionalized polyethylene glycol maleimide (PEG-MAL) hydrogels were engineered as a platform to deliver pancreatic islets to the small bowel mesentery and promote graft vascularization. VEGF, a potent stimulator of angiogenesis, was incorporated into the hydrogel to be released in an on-demand manner through enzymatic degradation. PEG-MAL hydrogel enabled extended in vivo release of VEGF. Isolated rat islets encapsulated in PEG-MAL hydrogels remained viable in culture and secreted insulin. Islets encapsulated in PEG-MAL matrix and transplanted to the small bowel mesentery of healthy rats grafted to the host tissue and revascularized by 4 weeks. Addition of VEGF release to the PEG-MAL matrix greatly augmented the vascularization response. These results establish PEG-MAL engineered matrices as a vascular-inductive cell delivery vehicle and warrant their further investigation as islet transplantation vehicles in diabetic animal models. PMID:25787738

  18. Automated lithology prediction from PGNAA and other geophysical logs.

    PubMed

    Borsaru, M; Zhou, B; Aizawa, T; Karashima, H; Hashimoto, T

    2006-02-01

    Different methods of lithology predictions from geophysical data have been developed in the last 15 years. The geophysical logs used for predicting lithology are the conventional logs: sonic, neutron-neutron, gamma (total natural-gamma) and density (backscattered gamma-gamma). The prompt gamma neutron activation analysis (PGNAA) is another established geophysical logging technique for in situ element analysis of rocks in boreholes. The work described in this paper was carried out to investigate the application of PGNAA to the lithology interpretation. The data interpretation was conducted using the automatic interpretation program LogTrans based on statistical analysis. Limited test suggests that PGNAA logging data can be used to predict the lithology. A success rate of 73% for lithology prediction was achieved from PGNAA logging data only. It can also be used in conjunction with the conventional geophysical logs to enhance the lithology prediction. PMID:16140021

  19. ExbBD-Dependent Transport of Maltodextrins through the Novel MalA Protein across the Outer Membrane of Caulobacter crescentus

    PubMed Central

    Neugebauer, Heidi; Herrmann, Christina; Kammer, Winfried; Schwarz, Gerold; Nordheim, Alfred; Braun, Volkmar

    2005-01-01

    the C. crescentus malA mutant was slower than permeation through the outer membrane of an E. coli lamB mutant, which suggests a low porin activity in C. crescentus. The pores of the C. crescentus porins are slightly larger than those of E. coli K-12, since maltotetraose supported growth of the C. crescentus malA mutant but failed to support growth of the E. coli lamB mutant. The data are consistent with the proposal that binding of maltodextrins to MalA requires energy and MalA actively transports maltodextrins with Kd values 1,000-fold smaller than those for the LamB porin and 100-fold larger than those for the vitamin B12 and ferric siderophore outer membrane transporters. MalA is the first example of an outer membrane protein for which an ExbB/ExbD-dependent transport of a nutrient other than iron and vitamin B12 has been demonstrated. PMID:16321934

  20. Oracle Log Buffer Queueing

    SciTech Connect

    Rivenes, A S

    2004-12-08

    The purpose of this document is to investigate Oracle database log buffer queuing and its affect on the ability to load data using a specialized data loading system. Experiments were carried out on a Linux system using an Oracle 9.2 database. Previous experiments on a Sun 4800 running Solaris had shown that 100,000 entities per minute was an achievable rate. The question was then asked, can we do this on Linux, and where are the bottlenecks? A secondary question was also lurking, how can the loading be further scaled to handle even higher throughput requirements? Testing was conducted using a Dell PowerEdge 6650 server with four CPUs and a Dell PowerVault 220s RAID array with 14 36GB drives and 128 MB of cache. Oracle Enterprise Edition 9.2.0.4 was used for the database and Red Hat Linux Advanced Server 2.1 was used for the operating system. This document will detail the maximum observed throughputs using the same test suite that was used for the Sun tests. A detailed description of the testing performed along with an analysis of bottlenecks encountered will be made. Issues related to Oracle and Linux will also be detailed and some recommendations based on the findings.

  1. Acoustic paramagnetic logging tool

    DOEpatents

    Vail, III, William B.

    1988-01-01

    New methods and apparatus are disclosed which allow measurement of the presence of oil and water in geological formations using a new physical effect called the Acoustic Paramagnetic Logging Effect (APLE). The presence of petroleum in formation causes a slight increase in the earth's magnetic field in the vicinity of the reservoir. This is the phenomena of paramagnetism. Application of an acoustic source to a geological formation at the Larmor frequency of the nucleons present causes the paramagnetism of the formation to disappear. This results in a decrease in the earth3 s magnetic field in the vicinity of the oil bearing formation. Repetitively frequency sweeping the acoustic source through the Larmor frequency of the nucleons present (approx. 2 kHz) causes an amplitude modulation of the earth's magnetic field which is a consequence of the APLE. The amplitude modulation of the earth's magnetic field is measured with an induction coil gradiometer and provides a direct measure of the amount of oil and water in the excitation zone of the formation . The phase of the signal is used to infer the longitudinal relaxation times of the fluids present, which results in the ability in general to separate oil and water and to measure the viscosity of the oil present. Such measurements may be preformed in open boreholes and in cased well bores.

  2. Neutron well logging

    SciTech Connect

    Smith, H. D. Jr.; Schultz, W. E.

    1985-01-08

    This invention relates to an improved method for determining the oil saturation of subsurface earth formations in the vicinity of a well borehole. High energy neutrons irradiate the subsurface earth formations and gamma rays caused by inelastic scatter with the subsurface earth formation constituent materials are measured. For a chosen borehole depth, gamma ray logs are taken in different situations: first, with the formation fluid water and oil mixture in an undisturbed state; second, after flushing the formation with alcohol to displace the formation water and oil mixture; and, finally, after flushing the alcohol from the formation with water to obtain a measurement with no oil in the formation. The gamma ray measurements obtained are then used to determine the oil saturation without requiring knowledge of the porosity of the earth formation, borehole conditions or formation type. When the original oil content of the formation is at a naturally flushed, or residual, oil saturation, the present invention may be used to determine the residual oil saturation.

  3. 3. Log bunkhouse (far left), log chicken house (left of ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Log bunkhouse (far left), log chicken house (left of center), equipment shed (center), and workshop (far right). View to northwest. - William & Lucina Bowe Ranch, County Road 44, 0.1 mile northeast of Big Hole River Bridge, Melrose, Silver Bow County, MT

  4. Unconventional neutron sources for oil well logging

    NASA Astrophysics Data System (ADS)

    Frankle, C. M.; Dale, G. E.

    2013-09-01

    Americium-Beryllium (AmBe) radiological neutron sources have been widely used in the petroleum industry for well logging purposes. There is strong desire on the part of various governmental and regulatory bodies to find alternate sources due to the high activity and small size of AmBe sources. Other neutron sources are available, both radiological (252Cf) and electronic accelerator driven (D-D and D-T). All of these, however, have substantially different neutron energy spectra from AmBe and thus cause significantly different responses in well logging tools. We report on simulations performed using unconventional sources and techniques to attempt to better replicate the porosity and carbon/oxygen ratio responses a well logging tool would see from AmBe neutrons. The AmBe response of these two types of tools is compared to the response from 252Cf, D-D, D-T, filtered D-T, and T-T sources.

  5. Logging Concessions Enable Illegal Logging Crisis in the Peruvian Amazon

    NASA Astrophysics Data System (ADS)

    Finer, Matt; Jenkins, Clinton N.; Sky, Melissa A. Blue; Pine, Justin

    2014-04-01

    The Peruvian Amazon is an important arena in global efforts to promote sustainable logging in the tropics. Despite recent efforts to achieve sustainability, such as provisions in the US-Peru Trade Promotion Agreement, illegal logging continues to plague the region. We present evidence that Peru's legal logging concession system is enabling the widespread illegal logging via the regulatory documents designed to ensure sustainable logging. Analyzing official government data, we found that 68.3% of all concessions supervised by authorities were suspected of major violations. Of the 609 total concessions, nearly 30% have been cancelled for violations and we expect this percentage to increase as investigations continue. Moreover, the nature of the violations indicate that the permits associated with legal concessions are used to harvest trees in unauthorized areas, thus threatening all forested areas. Many of the violations pertain to the illegal extraction of CITES-listed timber species outside authorized areas. These findings highlight the need for additional reforms.

  6. Logging concessions enable illegal logging crisis in the Peruvian Amazon.

    PubMed

    Finer, Matt; Jenkins, Clinton N; Sky, Melissa A Blue; Pine, Justin

    2014-01-01

    The Peruvian Amazon is an important arena in global efforts to promote sustainable logging in the tropics. Despite recent efforts to achieve sustainability, such as provisions in the US-Peru Trade Promotion Agreement, illegal logging continues to plague the region. We present evidence that Peru's legal logging concession system is enabling the widespread illegal logging via the regulatory documents designed to ensure sustainable logging. Analyzing official government data, we found that 68.3% of all concessions supervised by authorities were suspected of major violations. Of the 609 total concessions, nearly 30% have been cancelled for violations and we expect this percentage to increase as investigations continue. Moreover, the nature of the violations indicate that the permits associated with legal concessions are used to harvest trees in unauthorized areas, thus threatening all forested areas. Many of the violations pertain to the illegal extraction of CITES-listed timber species outside authorized areas. These findings highlight the need for additional reforms. PMID:24743552

  7. Modulating the immunological properties of a linear B-cell epitope by insertion into permissive sites of the MalE protein.

    PubMed

    Martineau, P; Leclerc, C; Hofnung, M

    1996-12-01

    In a previous study, a set of positions in the MalE protein from Escherichia coli were identified, which tolerated short insertions or deletions without compromising the maltose binding activity of the protein. It is now shown that these sites accommodate an insert of 13 amino acids and are, therefore, permissive. Eleven sites were used, including eight permissive sites, to display a linear neutralization B-cell epitope of poliovirus (C3 epitope) at different positions on the surface of MalE. The affinity of a monoclonal neutralizing anti-poliovirus antibody (anti-C3 mAb) for the hybrid proteins varied from undetectable, to more than 1000 times higher than for the synthetic peptide. Therefore, some MalEC3 proteins mimic interactions of the viral epitope with the monoclonal antibody more efficiently than the free peptide. The results are interpreted in terms of the mobility of the insert and its flanking regions. It was further shown that some of the purified hybrid proteins are able to induce high titer anti-C3-peptide antibodies in mice. A strong correlation exists between the capacity of a MalEC3 protein to induce anti-C3-peptide antibodies and the antigenicity of the inserted peptide, measured with a polyclonal serum raised against the synthetic peptide. PMID:9171894

  8. Well Logging with Californium-252

    SciTech Connect

    Boulogne, A.R.

    2003-01-06

    Californium-252 is an intense neutron emitter that has only recently become available for experimental well logging. The purpose of this research is to investigate the application of well logging to groundwater hydrology; however, most of the techniques and purposes are quite similar to applications in the petroleum industry.

  9. 7 CFR 1421.418 - Submitting MAL and LDP documentation to FSA.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... disbursement date, peanut type, warehouse code, and State where peanuts were inspected; and (2) LDPs with the... this section shall be submitted to FSA with the following documents: (1) Individual paper warehouse... receipts as one MAL or LDP, waive the service fee to the DMA, and either hold MAL paper warehouse...

  10. 7 CFR 1421.418 - Submitting MAL and LDP documentation to FSA.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... disbursement date, peanut type, warehouse code, and State where peanuts were inspected; and (2) LDPs with the... this section shall be submitted to FSA with the following documents: (1) Individual paper warehouse... receipts as one MAL or LDP, waive the service fee to the DMA, and either hold MAL paper warehouse...

  11. 7 CFR 1421.418 - Submitting MAL and LDP documentation to FSA.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... disbursement date, peanut type, warehouse code, and State where peanuts were inspected; and (2) LDPs with the... this section shall be submitted to FSA with the following documents: (1) Individual paper warehouse... receipts as one MAL or LDP, waive the service fee to the DMA, and either hold MAL paper warehouse...

  12. Mal de Debarquement Syndrome: A Rare Entity—A Case Report and Review of the Literature

    PubMed Central

    Nwagwu, Veronica; Patel, Rakesh; Okudo, Jerome

    2015-01-01

    Mal de Debarquement Syndrome (MDS) is a rare, understudied, underdiagnosed, and self-limiting condition. Etiology and incidence are unknown. It is characterized by abnormal sensation of motion/balance reported after travel by air, land, and sea; being reexposed to motion/activity relieves it. Symptoms may last from minutes to years. Workup though required reveals no findings; it is a diagnosis of exclusion. While no efficacious treatment exists, amitriptyline and benzodiazepines as well as supportive therapy have proved to be useful. We have described a 40-year-old Caucasian female who presented for the evaluation of persistent rocking and swaying sensation after a ship cruise which lasted for one week. Patient was treated with benzodiazepines after extensive workup and is now stable. A high index of suspicion is required to make a diagnosis. PMID:26346344

  13. A new approach for deriving pseudovelocity logs from resistivity logs

    SciTech Connect

    Dos Santos, W.L.B.; Ulrych, T.J.; De Lima, O.A.L.

    1988-01-01

    This paper describes a method of generating pseudovelocity logs using measurements of electrical resistivity. A theoretical relation between electrical resistivity and transit time, which is applicable to a wide range of lithologies, has been developed. The application of this relation using a method which defines lithoresistivity zones as lithological intervals related to the same formation and showing small resistivity variations, has been tested in the Reconcavo sedimentary basin in Bahia, Brazil. A comparison of derived pseudovelocity logs with actual sonic logs for five wells shows the validity of the present approach.

  14. Modelling tropical forests response to logging

    NASA Astrophysics Data System (ADS)

    Cazzolla Gatti, Roberto; Di Paola, Arianna; Valentini, Riccardo; Paparella, Francesco

    2013-04-01

    Tropical rainforests are among the most threatened ecosystems by large-scale fragmentation due to human activity such as heavy logging and agricultural clearance. Although, they provide crucial ecosystem goods and services, such as sequestering carbon from the atmosphere, protecting watersheds and conserving biodiversity. In several countries forest resource extraction has experienced a shift from clearcutting to selective logging to maintain a significant forest cover and understock of living biomass. However the knowledge on the short and long-term effects of removing selected species in tropical rainforest are scarce and need to be further investigated. One of the main effects of selective logging on forest dynamics seems to be the local disturbance which involve the invasion of open space by weed, vines and climbers at the expense of the late-successional state cenosis. We present a simple deterministic model that describes the dynamics of tropical rainforest subject to selective logging to understand how and why weeds displace native species. We argue that the selective removal of tallest tropical trees carries out gaps of light that allow weeds, vines and climbers to prevail on native species, inhibiting the possibility of recovery of the original vegetation. Our results show that different regime shifts may occur depending on the type of forest management adopted. This hypothesis is supported by a dataset of trees height and weed/vines cover that we collected from 9 plots located in Central and West Africa both in untouched and managed areas.

  15. Flow rate logging seepage meter

    NASA Technical Reports Server (NTRS)

    Reay, William G. (Inventor); Walthall, Harry G. (Inventor)

    1996-01-01

    An apparatus for remotely measuring and logging the flow rate of groundwater seepage into surface water bodies. As groundwater seeps into a cavity created by a bottomless housing, it displaces water through an inlet and into a waterproof sealed upper compartment, at which point, the water is collected by a collection bag, which is contained in a bag chamber. A magnet on the collection bag approaches a proximity switch as the collection bag fills, and eventually enables the proximity switch to activate a control circuit. The control circuit then rotates a three-way valve from the collection path to a discharge path, enables a data logger to record the time, and enables a pump, which discharges the water from the collection bag, through the three-way valve and pump, and into the sea. As the collection bag empties, the magnet leaves the proximity of the proximity switch, and the control circuit turns off the pump, resets the valve to provide a collection path, and restarts the collection cycle.

  16. New materials for fireplace logs

    NASA Technical Reports Server (NTRS)

    Kieselback, D. J.; Smock, A. W.

    1971-01-01

    Fibrous insulation and refractory concrete are used for logs as well as fireproof walls, incinerator bricks, planters, and roof shingles. Insulation is lighter and more shock resistant than fireclay. Lightweight slag bonded with refractory concrete serves as aggregrate.

  17. Camphor: an herbal medicine causing grand mal seizures.

    PubMed

    MacKinney, Theodore G; Soti, Kamal Raj; Shrestha, Poojan; Basnyat, Buddha

    2015-01-01

    Camphor is usually used in the USA to repel insects, but it is widely used in other countries as an herb. We report the case of a 52-year-old previously healthy Nepali man who ingested approximately 10 g of pure camphor with therapeutic intention. He developed grand mal seizures, and was evaluated in an emergency room. He failed to recall the camphor ingestion initially, and was treated with phenytoin for new-onset idiopathic seizures. Examining physicians only later found out about his camphor ingestion. Finding the cause of new-onset seizures is often challenging for emergency room physicians, internists and neurologists. In addition to other well-reported causes of secondary seizures, herbal medications and supplements must also be explored. PMID:26065546

  18. Structure-function study of MalF protein by random mutagenesis.

    PubMed

    Tapia, M I; Mourez, M; Hofnung, M; Dassa, E

    1999-04-01

    MalF is one of the two integral inner membrane proteins of the maltose-maltodextrin transport system. To identify functional regions in this protein, we characterized a collection of malF mutants obtained by random mutagenesis. We analyzed their growth on maltose and maltodextrins, the steady-state levels and subcellular localization of the mutant proteins, and the subcellular localization of MalK. Only 2 of the 21 MalF mutant proteins allowed growth on maltose and maltodextrins. Most mutations resulting in immunodetectable proteins mapped to hydrophilic domains, indicating that insertions affecting transmembrane segments gave rise to unstable or lethal proteins. All MalF mutant proteins, even those C-terminally truncated or with large N-terminal deletions, were inserted into the cytoplasmic membrane. Having identified mutations leading to reduced steady-state level, to partial mislocation, and/or to misfolding, we were able to assign to some regions of MalF a role in the assembly of the MalFGK2 complex and/or in the transport mechanism. PMID:10094708

  19. Structure-Function Study of MalF Protein by Random Mutagenesis

    PubMed Central

    Tapia, María Isabel; Mourez, Michaël; Hofnung, Maurice; Dassa, Elie

    1999-01-01

    MalF is one of the two integral inner membrane proteins of the maltose-maltodextrin transport system. To identify functional regions in this protein, we characterized a collection of malF mutants obtained by random mutagenesis. We analyzed their growth on maltose and maltodextrins, the steady-state levels and subcellular localization of the mutant proteins, and the subcellular localization of MalK. Only 2 of the 21 MalF mutant proteins allowed growth on maltose and maltodextrins. Most mutations resulting in immunodetectable proteins mapped to hydrophilic domains, indicating that insertions affecting transmembrane segments gave rise to unstable or lethal proteins. All MalF mutant proteins, even those C-terminally truncated or with large N-terminal deletions, were inserted into the cytoplasmic membrane. Having identified mutations leading to reduced steady-state level, to partial mislocation, and/or to misfolding, we were able to assign to some regions of MalF a role in the assembly of the MalFGK2 complex and/or in the transport mechanism. PMID:10094708

  20. Temperature and volume estimation of under-seafloor fluid from the logging-while-drilling data beneath an active hydrothermal field

    NASA Astrophysics Data System (ADS)

    Hamada, Y.; Saito, S.; Sanada, Y.; Masaki, Y.; Moe, K.; Kido, Y. N.; Kumagai, H.; Takai, K.; Suzuki, K.

    2015-12-01

    In July of 2014, offshore drillings on Iheya-North Knoll, Okinawa Trough, was executed as part of Next-generation technology for ocean resources survey, which is a research program in Cross-ministerial Strategic Innovation Promotion Program (SIP). In this expedition, logging-while- drilling (LWD) and measuring-while-drilling (MWD) were inserted into 6 holes (C9011 - C9016) to investigate spatial distribution of hydrothermal deposit and geothermal fluid reservoir. Both of these tools included annular pressure-while-drilling (APWD). Annular pressure and temperature were monitored by the APWD to detect possible exceedingly-high-temperature geofluid. In addition, drilling fluid was continuously circulated at sufficient flow rate to protect LWD tools against high temperature (non-stop driller system). At C9012 and C9016, the LWD tool clearly detected pressure and temperature anomaly at 234 meter below the seafloor (mbsf) and 80 mbsf, respectively. Annular pressure and temperature quickly increases at that depth and it would reflect the injection of high-temperature fluid. During the drilling, however, drilling water was continuously circulated at high flow-rate (2600L/min) and the measured temperature is not exactly in-situ temperature. To investigate the detail of the heat source, such as in-situ temperature and quantity of heat, we performed numerical analyses of thermal fluid and energy-balance assuming injection of high-temperature fluid. We combined pressure loss theory of double cylinders and temperature equation to replicate the fluid flow and its temperature between borehole wall and drilling pipe during the thermofluid injection. As the result, we estimated the temperature and the volume of injected fluid to be 115oC~ and 17.3 m3, respectively (at C9012) from the calculation. This temperature is lower than that of a hydrothermall vent which had been found near the hole (300oC).

  1. Logging and Fire Effects in Siberian Boreal Forests

    NASA Astrophysics Data System (ADS)

    Kukavskaya, E.; Buryak, L.; Ivanova, G.; Kalenskaya, O.; Bogorodskaya, A.; Zhila, S.; McRae, D.; Conard, S. G.

    2013-12-01

    The Russian boreal zone supports a huge terrestrial carbon pool. Moreover, it is a tremendous reservoir of wood products concentrated mainly in Siberia. The main natural disturbance in these forests is wildfire, which modifies the carbon budget and has potentially important climate feedbacks. In addition, both legal and illegal logging increase landscape complexity and fire hazard. We investigated a number of sites in different regions of Siberia to evaluate the impacts of fire and logging on fuel loads, carbon emissions, tree regeneration, soil respiration, and microbocenosis. We found large variations of fire and logging effects among regions depending on growing conditions and type of logging activity. Partial logging had no negative impact on forest conditions and carbon cycle. Illegal logging resulted in increase of fire hazard, and higher carbon emissions than legal logging. The highest fuel loads and carbon emissions were found on repeatedly burned unlogged sites where first fire resulted in total tree mortality. Repeated fires together with logging activities in drier conditions and on large burned sites resulted in insufficient regeneration, or even total lack of tree seedlings. Soil respiration was less on both burned and logged areas than in undisturbed forest. The highest structural and functional disturbances of the soil microbocenosis were observed on logged burned sites. Understanding current interactions between fire and logging is important for modeling ecosystem processes and for managers to develop strategies of sustainable forest management. Changing patterns in the harvest of wood products increase landscape complexity and can be expected to increase emissions and ecosystem damage from wildfires, inhibit recovery of natural ecosystems, and exacerbate impacts of wildland fire on changing climate and air quality. The research was supported by NASA LCLUC Program, RFBR grant # 12-04-31258, and Russian Academy of Sciences.

  2. Inflow and outflow signatures in flowing wellbore electrical conductivity logs

    SciTech Connect

    Doughty, Christine; Tsang, Chin-Fu

    2002-08-28

    Flowing wellbore electrical-conductivity logging provides a means to determine hydrologic properties of fractures, fracture zones, or other permeable layers intersecting a borehole in saturated rock. The method involves analyzing the time-evolution of fluid electrical-conductivity logs obtained while the well is being pumped and yields information on the location, hydraulic transmissivity, and salinity of permeable layers, as well as their initial (or ambient) pressure head. Earlier analysis methods were restricted to the case in which flows from the permeable layers or fractures were directed into the borehole. More recently, a numerical model for simulating flowing-conductivity logging was adapted to permit treatment of both inflow and outflow, including analysis of natural regional flow in the permeable layer. However, determining the fracture properties with the numerical model by optimizing the match to the conductivity logs is a laborious trial-and-error procedure. In this paper, we identify the signatures of various inflow and outflow features in the conductivity logs to expedite this procedure and to provide physical insight for the analysis of these logs. Generally, inflow points are found to produce a distinctive signature on the conductivity logs themselves, enabling the determination of location, inflow rate, and ion concentration in a straightforward manner. Identifying outflow locations and flow rates, on the other hand, can be done with a more complicated integral method. Running a set of several conductivity logs with different pumping rates (e.g., half and double the original pumping rate) provides further information on the nature of the feed points. In addition to enabling the estimation of flow parameters from conductivity logs, an understanding of the conductivity log signatures can aid in the design of follow-up logging activities.

  3. Cutting Edge: Regulation of Exosome Secretion by the Integral MAL Protein in T Cells.

    PubMed

    Ventimiglia, Leandro N; Fernández-Martín, Laura; Martínez-Alonso, Emma; Antón, Olga M; Guerra, Milagros; Martínez-Menárguez, José Angel; Andrés, Germán; Alonso, Miguel A

    2015-08-01

    Exosomes secreted by T cells play an important role in coordinating the immune response. HIV-1 Nef hijacks the route of exosome secretion of T cells to modulate the functioning of uninfected cells. Despite the importance of the process, the protein machinery involved in exosome biogenesis is yet to be identified. In this study, we show that MAL, a tetraspanning membrane protein expressed in human T cells, is present in endosomes that travel toward the plasma membrane for exosome secretion. In the absence of MAL, the release of exosome particles and markers was greatly impaired. This effect was accompanied by protein sorting defects at multivesicular endosomes that divert the exosomal marker CD63 to autophagic vacuoles. Exosome release induced by HIV-1 Nef was also dependent on MAL expression. Therefore, MAL is a critical element of the machinery for exosome secretion and may constitute a target for modulating exosome secretion by human T cells. PMID:26109641

  4. Mail LOG: Program operating instructions

    NASA Technical Reports Server (NTRS)

    Harris, D. K.

    1979-01-01

    The operating instructions for the software package, MAIL LOG, developed for the Scout Project Automatic Data System, SPADS, are provided. The program is written in FORTRAN for the PRIME 300 computer system. The MAIL LOG program has the following four modes of operation: (1) INPUT - putting new records into the data base (2) REVISE - changing or modifying existing records in the data base (3) SEARCH - finding special records existing in the data base (4) ARCHIVE - store or put away existing records in the data base. The output includes special printouts of records in the data base and results from the INPUT and SEARCH modes. The MAIL LOG data base consists of three main subfiles: Incoming and outgoing mail correspondence; Design Information Releases and Releases and Reports; and Drawings and Engineering orders.

  5. Fatal grand mal seizure in a Dutch trekker.

    PubMed

    Basnyat, B

    1998-12-01

    A 35-year-old healthy Dutch woman went on a trek (Lang Tang) in Nepal up to an approximate altitude of about 3800 meters. She had no prior history of any medical problems except attacks of generalized epilepsy when she was 19 years old, which had been controlled with antiepileptic medications. She had had no attacks after the age of 20. A CT scan done around that time had apparently been normal. On this trek she had developed diarrhea which had been cured with norfloxacin 400 mg two times per day for 3 days. Two days later, while descending, she developed a grand mal seizure at an altitude of 3300 meters, after which she developed a classic postictal phase but gradually recovered. She developed grand mal seizures again the next day, but when she went to a travel clinic in Kathmandu, she had been seizure free for 72 hours. She also revealed that she had not suffered from acute mountain sickness on the trek. She also had a prior history of gastroenteritis at high altitude which improved significantly with norfloxacin, a quinolone antibiotic. This was corroborated by her party. Upon examination she was fully conscious and oriented to person, place and time. Her pulse was 70 beats per minute and her BP was 110/80 mm of Hg. Her fundi and cranial nerves exam were completely normal. Her abstract thinking, gait, power, tone, reflexes and other facets of her neurologic exam revealed absolutely no abnormalities. Her cardiovascular exam revealed a normal rhythm with no murmurs or bruits. The rest of her exam was also normal. She revealed that she played tennis on a regular basis and was an outdoor person. She had not trekked before in the Himalayas and it was uncertain if she had been to high altitude before. She was on no medications at the time. There was no history of drug abuse. She did not smoke and consumed few alcoholic beverages. She had not consumed any alcohol on the trek. She was advised to get a CT scan (she declined as she was going home to Holland in 2 days) and

  6. Postfire logging in riparian areas.

    PubMed

    Reeves, Gordon H; Bisson, Peter A; Rieman, Bruce E; Benda, Lee E

    2006-08-01

    We reviewed the behavior of wildfire in riparian zones, primarily in the western United States, and the potential ecological consequences of postfire logging. Fire behavior in riparian zones is complex, but many aquatic and riparian organisms exhibit a suite of adaptations that allow relatively rapid recovery after fire. Unless constrained by other factors, fish tend to rebound relatively quickly, usually within a decade after a wildfire. Additionally, fire and subsequent erosion events contribute wood and coarse sediment that can create and maintain productive aquatic habitats over time. The potential effects of postfire logging in riparian areas depend on the landscape context and disturbance history of a site; however available evidence suggests two key management implications: (1) fire in riparian areas creates conditions that may not require intervention to sustain the long-term productivity of the aquatic network and (2) protection of burned riparian areas gives priority to what is left rather than what is removed. Research is needed to determine how postfire logging in riparian areas has affected the spread of invasive species and the vulnerability of upland forests to insect and disease outbreaks and how postfire logging will affect the frequency and behavior of future fires. The effectiveness of using postfire logging to restore desired riparian structure and function is therefore unproven, but such projects are gaining interest with the departure of forest conditions from those that existed prior to timber harvest, fire suppression, and climate change. In the absence of reliable information about the potential consequence of postfire timber harvest, we conclude that providing postfire riparian zones with the same environmental protections they received before they burned isjustified ecologically Without a commitment to monitor management experiments, the effects of postfire riparian logging will remain unknown and highly contentious. PMID:16922216

  7. MAL Is a Regulator of the Recruitment of Myelin Protein PLP to Membrane Microdomains

    PubMed Central

    Bijlard, Marjolein; de Jonge, Jenny C.; Klunder, Bert; Nomden, Anita; Hoekstra, Dick; Baron, Wia

    2016-01-01

    In oligodendrocytes (OLGs), an indirect, transcytotic pathway is mediating transport of de novo synthesized PLP, a major myelin specific protein, from the apical-like plasma membrane to the specialized basolateral-like myelin membrane to prevent its premature compaction. MAL is a well-known regulator of polarized trafficking in epithelial cells, and given its presence in OLGs it was therefore of interest to investigate whether MAL played a similar role in PLP transport in OLGs, taking into account its timely expression in these cells. Our data revealed that premature expression of mCherry-MAL in oligodendrocyte progenitor cells interfered with terminal OLG differentiation, although myelin membrane formation per se was not impaired. In fact, also PLP transport to myelin membranes via the cell body plasma membrane was unaffected. However, the typical shift of PLP from TX-100-insoluble membrane domains to CHAPS-resistant, but TX-100-soluble membrane domains, seen in the absence of MAL expression, is substantially reduced upon expression of the MAL protein. Interestingly, not only in vitro, but also in developing brain a strongly diminished shift from TX-100 resistant to TX-100 soluble domains was observed. Consistently, the MAL-expression mediated annihilation of the typical membrane microdomain shift of PLP is also reflected by a loss of the characteristic surface expression profile of conformation-sensitive anti-PLP antibodies. Hence, these findings suggest that MAL is not involved in vesicular PLP trafficking to either the plasma membrane and/or the myelin membrane as such. Rather, we propose that MAL may regulate PLP’s distribution into distinct membrane microdomains that allow for lateral diffusion of PLP, directly from the plasma membrane to the myelin membrane once the myelin sheath has been assembled. PMID:27171274

  8. Method for induced polarization logging

    SciTech Connect

    Vinegar, H.J.; Waxman, M.H.

    1987-04-14

    A method is described for generating a log of the formation phase shift, resistivity and spontaneous potential of an earth formation from data obtained from the earth formation with a multi-electrode induced polarization logging tool. The method comprises obtaining data samples from the formation at measurement points equally spaced in time of the magnitude and phase of the induced voltage and the magnitude and phase of the current supplied by a circuit through a reference resistance R/sub 0/ to a survey current electrode associated with the tool.

  9. Design, Development, and Formative Evaluation of a Smartphone Application for Recording and Monitoring Physical Activity Levels: The 10,000 Steps "iStepLog"

    ERIC Educational Resources Information Center

    Kirwan, Morwenna; Duncan, Mitch J.; Vandelanotte, Corneel; Mummery, W. Kerry

    2013-01-01

    Objectives: Limited research exists addressing the development of health-related smartphone apps, a new and potentially effective health promotion delivery strategy. This article describes the development and formative evaluation of a smartphone app associated with a physical activity promotion website. Methods: A combination of qualitative and…

  10. Outdoor Education Student Log Book.

    ERIC Educational Resources Information Center

    Garbutt, Barbara; And Others.

    A student log book for outdoor education was developed to aid Oakland County (Michigan) teachers and supervisors of outdoor education in preparing student campers for their role and responsibilities in the total program. A sample letter to sixth graders explains the purpose of the booklet. General camp rules (10) are presented, followed by 6 woods…

  11. A New Approach to Logging.

    ERIC Educational Resources Information Center

    Miles, Donna

    2001-01-01

    In response to high numbers of preventable fatal accidents in the logging industry, the Occupational Safety and Health Administration (OSHA) developed a week-long logger safety training program that includes hands-on learning of safety techniques in the woods. Reaching small operators has been challenging; outreach initiatives in Maine, North…

  12. Dual spectra well logging system

    SciTech Connect

    Nussbaum, T.W.

    1982-09-07

    A dual spectra well logging system includes a well logging tool which is adapted to pass through a bore hole in an earth formation. The well logging tool includes at least two sensors which sense at least one condition of the earth formation and provides corresponding pulse signals. A circuit connected to the sensors provides a combined pulse signal wherein the pulses of the pulse signal from one sensor has one polarity and the pulses of the pulse signal from the other sensor has pulses of an opposite polarity. A circuit applies the combined pulse signal to a well logging cable which conducts the combined pulse signal to the surface of the earth formation. Surface apparatus includes a network connected to the cable which provides control signals in accordance with the polarity of the pulses in the combined pulse signal. A network connected to the cable inverts the combined pulse signal and provides a combined pulse signal and an inverted combined pulse signal. A first switching network receiving the combined pulse signal passes the pulses derived from the pulses of the one polarity in acccordance with the control signals to provide a first pulse signal while a second switching network receiving the inverted combined pulse signal passes the pulses derived from the pulses of the opposite polarity in accordance with the control signals to provide a second pulse signal. An output network processes the two pulse signals to provide an indication of the earth's condition in accordance with the processed pulse signals.

  13. Statistical log analysis made practical

    SciTech Connect

    Mitchell, W.K.; Nelson, R.J. )

    1991-06-01

    This paper discusses the advantages of a statistical approach to log analysis. Statistical techniques use inverse methods to calculate formation parameters. The use of statistical techniques has been limited, however, by the complexity of the mathematics and lengthy computer time required to minimize traditionally used nonlinear equations.

  14. CRYPTOSPORIDIUM LOG INACTIVATION CALCULATION METHODS

    EPA Science Inventory

    Appendix O of the Surface Water Treatment Rule (SWTR) Guidance Manual introduces the CeffT10 (i.e., reaction zone outlet C value and T10 time) method for calculating ozone CT value and Giardia and virus log inactivation. The LT2ESWTR Pre-proposal Draft Regulatory Language for St...

  15. SwampLog II: A Structured Journal for Personal and Professional Inquiry within a Collaborative Environment.

    ERIC Educational Resources Information Center

    Nicassio, Frank J.

    SwampLog is a type of journal keeping that records the facts of daily activities as experienced and perceived by practitioners. The label, "SwampLog," was inspired by Donald Schon's metaphor used to distinguish the "swamplands of practice" from the "high, hard ground of research." Keeping a SwampLog consists of recording four general types of…

  16. Functional expression and molecular characterization of Culex quinquefasciatus salivary α-glucosidase (MalI).

    PubMed

    Suthangkornkul, Rungarun; Sirichaiyakul, Phanthila; Sungvornyothin, Sungsit; Thepouyporn, Apanchanid; Svasti, Jisnuson; Arthan, Dumrongkiet

    2015-06-01

    Salivary α-glucosidases (MalI) have been much less characterized when compared with midgut α-glucosidases, which have been studied in depth. Few studies have been reported on the partial characterization of MalI, but no clear function has been ascribed. The aim of this study is to purify and characterize the recombinant Culex quinquefasciatus (CQ) α-glucosidase expressed in Pichia pastoris. The cDNA encoding mature Cx. quinquefasciatus α-glucosidase gene with polyhistidine tag (rCQMalIHis) was successfully cloned into the expression vector, pPICZαB, designated as pPICZαB/CQMalIHis. The activity of recombinant rCQMalIHis expressed in P. pastoris could be detected at 3.75U/ml, under optimal culture conditions. The purified rCQMalIHis showed a single band of molecular weight of approximately 92kDa on SDS-PAGE. After Endoglycosidase H digestion, a single band at 69kDa was found on SDS-PAGE analysis, suggesting that rCQMalIHis is a glycoprotein. Additionally, tryptic digestion and LC-MALDI MS/MS analysis suggested that the 69kDa band corresponds to the Cx. quinquefasciatus α-glucosidase. Thus, rCQMalIHis is a glycoprotein. The rCQMalIHis exhibited optimum pH and temperature at 5.5 and 35°C, respectively. The catalytic efficiency (kcat/Km) of the purified rCQMalIHis for maltotriose is higher than those for sucrose, maltotetraose, maltose and p-nitrophenyl-α-glucoside, indicating that the enzyme prefers maltotriose. Additionally, the rCQMalIHis is significantly inhibited by d-gluconic acid δ-lactone, but not by Mg(2+), Ca(2+) and EDTA. The rCQMalIHis is strongly inhibited by acarbose with IC50 67.8±5.6nM, but weakly inhibited by glucose with IC50 115.9±7.3mM. PMID:25746591

  17. Influence of logging on the effects of wildfire in Siberia

    NASA Astrophysics Data System (ADS)

    Kukavskaya, E. A.; Buryak, L. V.; Ivanova, G. A.; Conard, S. G.; Kalenskaya, O. P.; Zhila, S. V.; McRae, D. J.

    2013-12-01

    The Russian boreal zone supports a huge terrestrial carbon pool. Moreover, it is a tremendous reservoir of wood products concentrated mainly in Siberia. The main natural disturbance in these forests is wildfire, which modifies the carbon budget and has potentially important climate feedbacks. In addition, both legal and illegal logging increase landscape complexity and affect burning conditions and fuel consumption. We investigated 100 individual sites with different histories of logging and fire on a total of 23 study areas in three different regions of Siberia to evaluate the impacts of fire and logging on fuel loads, carbon emissions, and tree regeneration in pine and larch forests. We found large variations of fire and logging effects among regions depending on growing conditions and type of logging activity. Logged areas in the Angara region had the highest surface and ground fuel loads (up to 135 t ha-1), mainly due to logging debris. This resulted in high carbon emissions where fires occurred on logged sites (up to 41 tC ha-1). The Shushenskoe/Minusinsk and Zabaikal regions are characterized by better slash removal and a smaller amount of carbon emitted to the atmosphere during fires. Illegal logging, which is widespread in the Zabaikal region, resulted in an increase in fire hazard and higher carbon emissions than legal logging. The highest fuel loads (on average 108 t ha-1) and carbon emissions (18-28 tC ha-1) in the Zabaikal region are on repeatedly burned unlogged sites where trees fell on the ground following the first fire event. Partial logging in the Shushenskoe/Minusinsk region has insufficient impact on stand density, tree mortality, and other forest conditions to substantially increase fire hazard or affect carbon stocks. Repeated fires on logged sites resulted in insufficient tree regeneration and transformation of forest to grasslands. We conclude that negative impacts of fire and logging on air quality, the carbon cycle, and ecosystem

  18. Temperature compensated well logging tool

    SciTech Connect

    Riedesel, R.G.; Nussbaum, T.W.; Warren, W.F.

    1984-01-24

    A well logging tool adapted for use in a borehole traversing an earth formation includes at least one sensor sensing at least one characteristic of the earth formation. Another sensor senses the ambient temperature and provides a corresponding temperature signal. An output circuit provides a temperature compensated output signal corresponding to the sensed characteristic of the earth formation in accordance with the temperature signal and the characteristic signal.

  19. Chemical logging of geothermal wells

    DOEpatents

    Allen, C.A.; McAtee, R.E.

    The presence of geothermal aquifers can be detected while drilling in geothermal formations by maintaining a chemical log of the ratio of the concentrations of calcium to carbonate and bicarbonate ions in the return drilling fluid. A continuous increase in the ratio of the concentrations of calcium to carbonate and bicarbonate ions is indicative of the existence of a warm or hot geothermal aquifer at some increased depth.

  20. Chemical logging of geothermal wells

    DOEpatents

    Allen, Charles A.; McAtee, Richard E.

    1981-01-01

    The presence of geothermal aquifers can be detected while drilling in geothermal formations by maintaining a chemical log of the ratio of the concentrations of calcium to carbonate and bicarbonate ions in the return drilling fluid. A continuous increase in the ratio of the concentrations of calcium to carbonate and bicarbonate ions is indicative of the existence of a warm or hot geothermal aquifer at some increased depth.

  1. Audit Log for Forensic Photography

    NASA Astrophysics Data System (ADS)

    Neville, Timothy; Sorell, Matthew

    We propose an architecture for an audit log system for forensic photography, which ensures that the chain of evidence of a photograph taken by a photographer at a crime scene is maintained from the point of image capture to its end application at trial. The requirements for such a system are specified and the results of experiments are presented which demonstrate the feasibility of the proposed approach.

  2. Comparison of the effectiveness of active and passive neuromuscular electrical stimulation of hemiplegic upper extremities: a randomized, controlled trial.

    PubMed

    Boyaci, Ahmet; Topuz, Oya; Alkan, Hakan; Ozgen, Merih; Sarsan, Ayse; Yildiz, Necmettin; Ardic, Fusun

    2013-12-01

    To compare the efficacy of electromyography (EMG)-triggered (active) neuromuscular electrical stimulation (NMES) and passive NMES in enhancing the upper extremity (UE) motor and functional recovery of subacute and chronic stage stroke patients. Thirty-one hemiplegic patients were randomly assigned to active NMES (n=11), passive NMES (n=10), and control (sham stimulation) (n=10) groups. Each treatment regimen was applied five times per week for 45 min for 3 weeks. All of the patients performed the same neurophysiologic exercise program for 45 min five times per week for 3 weeks. Patients were assessed by the UE component of the Fugl-Meyer Motor Assessment (UE-FMA), the self-care component of the Functional Independence Measure (self-care FIM), the Motor Activity Log (MAL), goniometric measurements of active wrist and metacarpophalangeal joint extension, surface EMG potentials, grip strength, and the modified Ashworth scale in a blinded manner. Data were obtained before and at the end of the treatment. Participants were similar in all clinical and demographic features (P>0.05). All groups were comparable with respect to UE-FMA, MAL, self-care FIM, wrist and finger flexor spasticity, active range of motion (ROM), grip strength, and surface EMG potentials before treatment (P>0.05). The active ROM, grip strength, FMA, FIM, surface EMG potentials, and MAL: amount of use were significantly improved in the EMG-triggered NMES group compared with the controls (P<0.05). The active wrist extension ROM and FMA scores were significantly improved in the passive NMES group compared with the controls (P<0.05). There were no statistically significant differences between active and passive NMES groups in any of the parameters evaluated at the end of the treatment (P>0.05). Both active and passive NMES as adjuvant therapy in the neurophysiologic exercise program effectively enhanced the UE motor and functional recovery of stroke survivors. PMID:23579106

  3. Interaction of PLP with GFP-MAL2 in the human oligodendroglial cell line HOG.

    PubMed

    Bello-Morales, Raquel; Pérez-Hernández, Marta; Rejas, María Teresa; Matesanz, Fuencisla; Alcina, Antonio; López-Guerrero, José Antonio

    2011-01-01

    The velocity of the nerve impulse conduction of vertebrates relies on the myelin sheath, an electrically insulating layer that surrounds axons in both the central and peripheral nervous systems, enabling saltatory conduction of the action potential. Oligodendrocytes are the myelin-producing glial cells in the central nervous system. A deeper understanding of the molecular basis of myelination and, specifically, of the transport of myelin proteins, will contribute to the search of the aetiology of many dysmyelinating and demyelinating diseases, including multiple sclerosis. Recent investigations suggest that proteolipid protein (PLP), the major myelin protein, could reach myelin sheath by an indirect transport pathway, that is, a transcytotic route via the plasma membrane of the cell body. If PLP transport relies on a transcytotic process, it is reasonable to consider that this myelin protein could be associated with MAL2, a raft protein essential for transcytosis. In this study, carried out with the human oligodendrocytic cell line HOG, we show that PLP colocalized with green fluorescent protein (GFP)-MAL2 after internalization from the plasma membrane. In addition, both immunoprecipitation and immunofluorescence assays, indicated the existence of an interaction between GFP-MAL2 and PLP. Finally, ultrastructural studies demonstrated colocalization of GFP-MAL2 and PLP in vesicles and tubulovesicular structures. Taken together, these results prove for the first time the interaction of PLP and MAL2 in oligodendrocytic cells, supporting the transcytotic model of PLP transport previously suggested. PMID:21573057

  4. Optimized Hypergraph Clustering-based Network Security Log Mining*

    NASA Astrophysics Data System (ADS)

    Che, Jianhua; Lin, Weimin; Yu, Yong; Yao, Wei

    With network's growth and popularization, network security experts are facing bigger and bigger network security log. Network security log is a kind of valuable and important information recording various network behaviors, and has the features of large-scale and high dimension. Therefore, how to analyze these network security log to enhance the security of network becomes the focus of many researchers. In this paper, we first design a frequent attack sequencebased hypergraph clustering algorithm to mine the network security log, and then improve this algorithm with a synthetic measure of hyperedge weight and two optimization functions of clustering result. The experimental results show that the synthetic measure and optimization functions can promote significantly the coverage and precision of clustering result. The optimized hypergraph clustering algorithm provides a data analyzing method for intrusion detecting and active forewarning of network.

  5. An innovative OSCE clinical log station: a quantitative study of its influence on Log use by medical students

    PubMed Central

    2012-01-01

    Background A Clinical Log was introduced as part of a medical student learning portfolio, aiming to develop a habit of critical reflection while learning was taking place, and provide feedback to students and the institution on learning progress. It was designed as a longitudinal self-directed structured record of student learning events, with reflection on these for personal and professional development, and actions planned or taken for learning. As incentive was needed to encourage student engagement, an innovative Clinical Log station was introduced in the OSCE, an assessment format with established acceptance at the School. This study questions: How does an OSCE Clinical Log station influence Log use by students? Methods The Log station was introduced into the formative, and subsequent summative, OSCEs with careful attention to student and assessor training, marking rubrics and the standard setting procedure. The scoring process sought evidence of educational use of the log, and an ability to present and reflect on key learning issues in a concise and coherent manner. Results Analysis of the first cohort’s Log use over the four-year course (quantified as number of patient visits entered by all students) revealed limited initial use. Usage was stimulated after introduction of the Log station early in third year, with some improvement during the subsequent year-long integrated community-based clerkship. Student reflection, quantified by the mean number of characters in the ‘reflection’ fields per entry, peaked just prior to the final OSCE (mid-Year 4). Following this, very few students continued to enter and reflect on clinical experience using the Log. Conclusion While the current study suggested that we can’t assume students will self-reflect unless such an activity is included in an assessment, ongoing work has focused on building learner and faculty confidence in the value of self-reflection as part of being a competent physician. PMID:23140250

  6. Avian responses to selective logging shaped by species traits and logging practices.

    PubMed

    Burivalova, Zuzana; Lee, Tien Ming; Giam, Xingli; Şekercioğlu, Çağan Hakkı; Wilcove, David S; Koh, Lian Pin

    2015-06-01

    Selective logging is one of the most common forms of forest use in the tropics. Although the effects of selective logging on biodiversity have been widely studied, there is little agreement on the relationship between life-history traits and tolerance to logging. In this study, we assessed how species traits and logging practices combine to determine species responses to selective logging, based on over 4000 observations of the responses of nearly 1000 bird species to selective logging across the tropics. Our analysis shows that species traits, such as feeding group and body mass, and logging practices, such as time since logging and logging intensity, interact to influence a species' response to logging. Frugivores and insectivores were most adversely affected by logging and declined further with increasing logging intensity. Nectarivores and granivores responded positively to selective logging for the first two decades, after which their abundances decrease below pre-logging levels. Larger species of omnivores and granivores responded more positively to selective logging than smaller species from either feeding group, whereas this effect of body size was reversed for carnivores, herbivores, frugivores and insectivores. Most importantly, species most negatively impacted by selective logging had not recovered approximately 40 years after logging cessation. We conclude that selective timber harvest has the potential to cause large and long-lasting changes in avian biodiversity. However, our results suggest that the impacts can be mitigated to a certain extent through specific forest management strategies such as lengthening the rotation cycle and implementing reduced impact logging. PMID:25994673

  7. Tucker Wireline Open Hole Wireline Logging

    SciTech Connect

    Milliken, M.

    2002-05-23

    The Tucker Wireline unit ran a suite of open hole logs right behind the RMOTC logging contractor for comparison purposes. The tools included Dual Laterolog, Phased Induction, BHC Sonic, and Density-Porosity.

  8. Data Mining of Network Logs

    NASA Technical Reports Server (NTRS)

    Collazo, Carlimar

    2011-01-01

    The statement of purpose is to analyze network monitoring logs to support the computer incident response team. Specifically, gain a clear understanding of the Uniform Resource Locator (URL) and its structure, and provide a way to breakdown a URL based on protocol, host name domain name, path, and other attributes. Finally, provide a method to perform data reduction by identifying the different types of advertisements shown on a webpage for incident data analysis. The procedures used for analysis and data reduction will be a computer program which would analyze the URL and identify and advertisement links from the actual content links.

  9. Tracking the Inside Intruder Using Net Log on Debug Logging in Microsoft Windows Server Operating Systems

    SciTech Connect

    Davis, CS

    2004-01-20

    In today's well-connected environments of the Internet, intranets, and extranets, protecting the Microsoft Windows network can be a daunting task for the security engineer. Intrusion Detection Systems are a must-have for most companies, but few have either the financial resources or the people resources to implement and maintain full-scale intrusion detection systems for their networks and hosts. Many will at least invest in intrusion detection for their Internet presence, but others have not yet stepped up to the plate with regard to internal intrusion detection. Unfortunately, most attacks will come from within. Microsoft Windows server operating systems are widely used across both large and small enterprises. Unfortunately, there is no intrusion detection built-in to the Windows server operating system. The security logs are valuable but can be difficult to manage even in a small to medium sized environment. So the question arises, can one effectively detect and identify an in side intruder using the native tools that come with Microsoft Windows Server operating systems? One such method is to use Net Logon Service debug logging to identify and track malicious user activity. This paper discusses how to use Net Logon debug logging to identify and track malicious user activity both in real-time and for forensic analysis.

  10. Balloon logging with the inverted skyline

    NASA Technical Reports Server (NTRS)

    Mosher, C. F.

    1975-01-01

    There is a gap in aerial logging techniques that has to be filled. The need for a simple, safe, sizeable system has to be developed before aerial logging will become effective and accepted in the logging industry. This paper presents such a system designed on simple principles with realistic cost and ecological benefits.

  11. 47 CFR 80.409 - Station logs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Station logs. 80.409 Section 80.409 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES STATIONS IN THE MARITIME SERVICES Station Documents § 80.409 Station logs. (a) General requirements. Logs must be established and properly maintained as follows:...

  12. 47 CFR 80.409 - Station logs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Station logs. 80.409 Section 80.409 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES STATIONS IN THE MARITIME SERVICES Station Documents § 80.409 Station logs. (a) General requirements. Logs must be established and properly maintained as follows:...

  13. Rising Mal-Employment and the Great Recession: The Growing Disconnection between Recent College Graduates and the College Labor Market

    ERIC Educational Resources Information Center

    Fogg, Neeta P.; Harrington, Paul E.

    2011-01-01

    This article looks at the phenomenon of mal-employment among college graduates in the United States, beginning with an overview of labor-market trends and the effects of the Great Recession on the job-market experiences of young people, including recent college graduates. It then defines "mal-employment" and examines its incidence over time. The…

  14. Change in Myself-as-a-Learner Scale (MALS) Scores as Pupils Transfer to and Progress through Secondary School

    ERIC Educational Resources Information Center

    Norgate, Roger; Osborne, Cara; Warhurst, Amy

    2013-01-01

    Longitudinal changes in pupils' academic self-perception (as measured by Myself-As-a-Learner Scale [MALS]) were investigated between Year 6 and Year 10. The possibility of there being gender and attainment differences was also explored. There was a significant drop in mean MALS scores between Years 6 and 7. There was a further drop between…

  15. Spatio-temporal analysis of human electroencephalograms: Petit-mal epilepsy

    NASA Astrophysics Data System (ADS)

    Friedrich, R.; Uhl, C.

    An analysis of multigrid electroencephalograms (EEG) derived from two different persons suffering from petit-mal epilepsy is performed. Using a previously devised method for analyzing spatio-temporal patterns (Uhl, et al., Z. Phys. B 92 (1993) 211-219), we find a suitable mode decomposition of the EEG. Additionally, we are able to extract a three-dimensional dynamical system which describes the dynamics of the patterns as a kind of mode interaction. We show that the spike-wave behavior characteristic for petit-mal epilepsy arising in the dynamical system is related with Sil'nikov-type behavior of the mode dynamics.

  16. A Different Presentation of Mal De Meleda: New Skin Lesions in a Residual Limb after Traumatic Amputation.

    PubMed

    Adıgüzel, Emre; Yüksel, Emine; Safaz, İsmail; Kenan Tan, Arif

    2016-06-01

    Mal de Meleda is a rare autosomal recessive skin disease which is known as keratoderma palmoplantaris transgradiens. Here we report a case of Mal de Meleda who had skin lesions in the residual limb and pseudoainhum in the thigh after traumatic lower leg amputation. A 71-year-old female was admitted to our tertiary hospital for prosthetic rehabilitation. On the physical examination, thickening of the skin on palms, left sole and residual limb was present. The patient reported that she had these skin lesions since infancy and she realized new skin lesions after amputation in the residual limb. We requested dermatology consultation and she was diagnosed as Mal de Meleda. To our knowledge, this is the first Mal de Meleda case in the literature with new lesions at the residual limb. Although exact pathophysiological mechanisms are not well known in Mal de Meleda, prosthesis use might have accelerated disease process in our patient. PMID:27477174

  17. Logs Wanted - Dead or Alive

    NASA Astrophysics Data System (ADS)

    Schuchardt, A.; Morche, D.

    2015-12-01

    Rivers cover only a small part of the Earth`s surface, yet they transfer sediment in globally significant quantities. In mountainous regions, the majority of the total channel length occurs in headwater streams. Those mountain channels are influenced in terms of sediment connectivity by processes on the slopes. For example in such a sediment routing system, sediment originating from debris flows on the slopes is delivered along sediment pathways to the channel system and can be transported further downstream as solid load. Interruption of instream coarse sediment connectivity is closely related to the existence of channel blocking barriers which also can be formed by biota. By storing sediment large wood (LW) log jams disrupt in-channel sediment connectivity. We present a study design in order to decipher the short to long term effects (c. 10-2-102 years) of sediment (dis)connectivity effects of large wood. The study areas are two basins in mountain ranges in Germany and Austria. In Austria the drainage area of the river Fugnitz was chosen which is located in the National Park Thayatal. The other drainage area of the river Sieber in Saxony-Anhalt, Germany, is located in the Harz National Park. Since studies on LW and its geomorphological effects in Central European rivers are still rare the main goals of the project are: •to identify important triggers for LW transport from slopes into the channels •to examine the spatial distribution and characterization of LW in main and slope channels by mapping and dGPS measurements •to determine the effects of LW on channel hydraulic parameters (e.g. slope, width, grains size composition, roughness) by field measurements of channel long profiles and cross section with dGPS and Wolman particle counts •to quantify the direct effects of LW on discharge and bed load transport by measuring flow velocity with an Ott-Nautilus current meter and to measure bed load up- and downstream of log jams using a portable Helley

  18. Voxel Based Morphometry Alterations in Mal de Debarquement Syndrome

    PubMed Central

    Cha, Yoon-Hee; Chakrapani, Shruthi

    2015-01-01

    Background Mal de debarquement syndrome (MdDS) is a disorder of chronic self-motion perception that occurs though entrainment to rhythmic background motion, such as from sea voyage, and involves the perception of low-frequency rocking that can last for months or years. The neural basis of this persistent sensory perception abnormality is not well understood. Methods We investigated grey matter volume differences underlying persistent MdDS by performing voxel-based morphometry on whole brain and pre-specified ROIs in 28 individuals with MdDS and comparing them to 18 age, sex, and handedness matched controls. Results MdDS participants exhibited greater grey matter volume in the left inferior parietal lobule, right inferior occipital gyrus (area V3v), right temporal pole, bilateral cerebellar hemispheric lobules VIII/IX and left lobule VIIa/VIIb. Grey matter volumes were lower in bilateral inferior frontal, orbitofrontal, pregenual anterior cingulate cortex (pgACC) and left superior medial gyri (t = 3.0, p<0.005uncorr). In ROI analyses, there were no volume differences in the middle occipital gyrus (region of V5/MT) or parietal operculum 2 (region of the parietoinsular vestibular cortex). Illness duration was positively related to grey matter volume in bilateral inferior frontal gyrus/anterior insula (IFG/AI), right posterior insula, superior parietal lobule, left middle occipital gyrus (V5/MT), bilateral postcentral gyrus, anterior cerebellum, and left cerebellar hemisphere and vermian lobule IX. In contrast, illness duration was negatively related to volume in pgACC, posterior middle cingulate gyrus (MCC), left middle frontal gyrus (dorsolateral prefrontal cortex-DLPFC), and right cerebellar hemispheric lobule VIIIb (t = 3.0, p<0.005uncorr). The most significant differences were decreased volume in the pgACC and increased volume in the left IFG/AI with longer illness duration (qFDRcorr <0.05). Concurrent medication use did not correlate with these findings or have a

  19. Leak checker data logging system

    DOEpatents

    Gannon, J.C.; Payne, J.J.

    1996-09-03

    A portable, high speed, computer-based data logging system for field testing systems or components located some distance apart employs a plurality of spaced mass spectrometers and is particularly adapted for monitoring the vacuum integrity of a long string of a superconducting magnets such as used in high energy particle accelerators. The system provides precise tracking of a gas such as helium through the magnet string when the helium is released into the vacuum by monitoring the spaced mass spectrometers allowing for control, display and storage of various parameters involved with leak detection and localization. A system user can observe the flow of helium through the magnet string on a real-time basis hour the exact moment of opening of the helium input valve. Graph reading can be normalized to compensate for magnet sections that deplete vacuum faster than other sections between testing to permit repetitive testing of vacuum integrity in reduced time. 18 figs.

  20. Log interpretation of shaly sandstones

    SciTech Connect

    Baker, J.F.

    1988-01-01

    The determination of water saturation from electrical resistivity measurements to evaluate the potential of reservoirs is a fundamental tool of the oil industry. Shaly sandstones are difficult to evaluate because clays are conductive and they lower the resistivity of the rock. A review of shaly-sandstone research concerning ''volume-of-shale'' equations reveals three theoretical categories: (1) laminated clay equations, (2) dispersed clay equations, and (3) equations that assume that the effect of the clays on the conductivity measurement is directly related to water saturation. A new model for predicting the relative amounts of laminated and dispersed shales and accounting for their effects according to their abundance can be used for any sandstone, clean or shaly. Equations representing each of the three theoretical categories and the new equation were tested on cored Wilcox sandstones from two wells. Cores were analyzed to determine the volume and distribution of clays and to correlate porosity with the well logs.

  1. Analysis of Web Proxy Logs

    NASA Astrophysics Data System (ADS)

    Fei, Bennie; Eloff, Jan; Olivier, Martin; Venter, Hein

    Network forensics involves capturing, recording and analysing network audit trails. A crucial part of network forensics is to gather evidence at the server level, proxy level and from other sources. A web proxy relays URL requests from clients to a server. Analysing web proxy logs can give unobtrusive insights to the browsing behavior of computer users and provide an overview of the Internet usage in an organisation. More importantly, in terms of network forensics, it can aid in detecting anomalous browsing behavior. This paper demonstrates the use of a self-organising map (SOM), a powerful data mining technique, in network forensics. In particular, it focuses on how a SOM can be used to analyse data gathered at the web proxy level.

  2. Leak checker data logging system

    DOEpatents

    Gannon, Jeffrey C.; Payne, John J.

    1996-01-01

    A portable, high speed, computer-based data logging system for field testing systems or components located some distance apart employs a plurality of spaced mass spectrometers and is particularly adapted for monitoring the vacuum integrity of a long string of a superconducting magnets such as used in high energy particle accelerators. The system provides precise tracking of a gas such as helium through the magnet string when the helium is released into the vacuum by monitoring the spaced mass spectrometers allowing for control, display and storage of various parameters involved with leak detection and localization. A system user can observe the flow of helium through the magnet string on a real-time basis hour the exact moment of opening of the helium input valve. Graph reading can be normalized to compensate for magnet sections that deplete vacuum faster than other sections between testing to permit repetitive testing of vacuum integrity in reduced time.

  3. Leak checker data logging system

    SciTech Connect

    Payne, J.J.; Gannon, J.C.

    1994-12-31

    A portable, high speed, computer-based data logging system for field testing systems or components located some distance apart employs a plurality of spaced mass spectrometers and is particularly adapted for monitoring the vacuum integrity of a long string of a superconducting magnets such as used in high energy particle accelerators. The system provides precise tracking of a gas such as helium through the magnet string when the helium is released into the vacuum by monitoring the spaced mass spectrometers allowing for control, display and storage of various parameters involved with leak detection and localization. A system user can observe the flow of helium through the magnet string on a real-time basis hour the exact moment of opening of the helium input valve. Graph reading can be normalized to compensate for magnet sections that deplete vacuum faster than other sections between testing to permit repetitive testing of vacuum integrity in reduced time.

  4. 7 CFR 1421.418 - Submitting MAL and LDP documentation to FSA.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 10 2011-01-01 2011-01-01 false Submitting MAL and LDP documentation to FSA. 1421.418 Section 1421.418 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS GRAINS AND SIMILARLY HANDLED COMMODITIES-MARKETING ASSISTANCE...

  5. 7 CFR 1421.418 - Submitting MAL and LDP documentation to FSA.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 10 2012-01-01 2012-01-01 false Submitting MAL and LDP documentation to FSA. 1421.418 Section 1421.418 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS GRAINS AND SIMILARLY HANDLED COMMODITIES-MARKETING ASSISTANCE...

  6. Correlating Log Messages for System Diagnostics

    SciTech Connect

    Gunasekaran, Raghul; Dillow, David A; Shipman, Galen M; Maxwell, Don E; Hill, Jason J; Park, Byung H; Geist, Al

    2010-01-01

    In large-scale computing systems, the sheer volume of log data generated presents daunting challenges for debugging and monitoring of these systems. The Oak Ridge Leadership Computing Facility s premier simulation platform, the Cray XT5 known as Jaguar, can generate a few hundred thousand log entries in less than a minute for many system level events. Determining the root cause of such system events requires analyzing and interpretation of a large number of log messages. Most often, the log messages are best understood when they are interpreted collectively rather than individually. In this paper, we present our approach to interpreting log messages by identifying their commonalities and grouping them into clusters. Given a set of log messages within a time interval, we group the messages based on source, target, and/or error type, and correlate the messages with hardware and application information. We monitor the Lustre log messages in the XT5 console log and show that such grouping of log messages assists in detecting the source of system events. By intelligent grouping and correlation of events in the log, we are able to provide system administrators with meaningful information in a concise format for root cause analysis.

  7. Step-by-step thermal transformations of a new porous coordination polymer [(H2O)5CuBa(Me2mal)2]n (Me2mal2-=dimethylmalonate): Thermal degradation to barium cuprate

    NASA Astrophysics Data System (ADS)

    Zauzolkova, Natalya; Dobrokhotova, Zhanna; Lermontov, Anatoly; Zorina, Ekaterina; Emelina, Anna; Bukov, Mikhail; Chernyshev, Vladimir; Sidorov, Aleksey; Kiskin, Mikhail; Bogomyakov, Artem; Lytvynenko, Anton; Kolotilov, Sergey; Velikodnyi, Yuriy; Kovba, Maksim; Novotortsev, Vladimir; Eremenko, Igor

    2013-01-01

    The reactions of CuSO4·5H2O, dimethylmalonic acid and Ba(OH)2·H2O (Cu: H2Me2mal: Ba=1: 2: 2) in aqueous and aqueous-ethanol solutions (H2O: EtOH=1: 1) resulted in formation of 3D-porous coordination polymers [(H2O)3(μ-H2O)2CuBa(μ3-Me2mal)(Me2mal)]n (1) and [(μ-H2O)CuBa(μ3-Me2mal)(μ4-Me2mal)]n (2), respectively. It has been shown that compound 2 was an intermediate in the thermal degradation of compound 1. Thorough studies of solid-state thermolysis of 1 and 2 allowed to detect formation of coordination polymer [CuBa(μ4-Me2mal)(μ5-Me2mal)]n (3), structure of which was determined by X-ray powder diffraction. It has been found that the channels in polymer 3 were accessible for guest molecules (MeOH). Theoretical estimation of methanol diffusion barrier was carried out. Complete solid-phase thermolysis of 1 and 2 leads to a mixture of BaCuO2, BaCO3, and CuO. Special conditions for obtaining of a crystalline phase of pure cubic BaCuO2 were determined.

  8. A critical role for the TLR signaling adapter Mal in alveolar macrophage-mediated protection against Bordetella pertussis.

    PubMed

    Bernard, N J; Finlay, C M; Tannahill, G M; Cassidy, J P; O'Neill, L A; Mills, K H G

    2015-09-01

    Bordetella pertussis causes whooping cough, an infectious disease of the respiratory tract that is re-emerging despite high vaccine coverage. Here we examined the role of Toll-like receptor (TLR) adapter protein Mal in the control of B. pertussis infection in the lungs. We found that B. pertussis bacterial load in the lungs of Mal-defective (Mal(-/-)) mice exceeded that of wild-type (WT) mice by up to 100-fold and bacteria disseminated to the liver in Mal(-/-) mice and 50% of these mice died from the infection. Macrophages from Mal(-/-) mice were defective in an early burst of pro-inflammatory cytokine production and in their ability to kill or constrain intracellular growth of B. pertussis. Importantly, the B. pertussis bacterial load in the lungs inversely correlated with the number of alveolar macrophages. Despite the maintenance and expansion of other cell populations, alveolar macrophages were completely depleted from the lungs of infected Mal(-/-) mice, but not from infected WT mice. Our findings define for the first time a role for a microbial pattern-recognition pathway in the survival of alveolar macrophages and uncover a mechanism of macrophage-mediated immunity to B. pertussis in which Mal controls intracellular survival and dissemination of bacteria from the lungs. PMID:25515629

  9. Optimal message log reclamation for independent checkpointing

    NASA Technical Reports Server (NTRS)

    Wang, Yi-Min; Fuchs, W. Kent

    1993-01-01

    Independent (uncoordinated) check pointing for parallel and distributed systems allows maximum process autonomy but suffers from possible domino effects and the associated storage space overhead for maintaining multiple checkpoints and message logs. In most research on check pointing and recovery, it was assumed that only the checkpoints and message logs older than the global recovery line can be discarded. It is shown how recovery line transformation and decomposition can be applied to the problem of efficiently identifying all discardable message logs, thereby achieving optimal garbage collection. Communication trace-driven simulation for several parallel programs is used to show the benefits of the proposed algorithm for message log reclamation.

  10. 29 CFR 1917.18 - Log handling.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 7 2010-07-01 2010-07-01 false Log handling. 1917.18 Section 1917.18 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) MARINE TERMINALS Marine Terminal Operations § 1917.18 Log handling. (a) The employer shall ensure...

  11. 40 CFR 90.412 - Data logging.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 20 2014-07-01 2013-07-01 true Data logging. 90.412 Section 90.412....412 Data logging. (a) A computer or any other automatic data collection (ADC) device(s) may be used as long as the system meets the requirements of this subpart. (b) Determine from the data...

  12. 40 CFR 89.409 - Data logging.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 21 2012-07-01 2012-07-01 false Data logging. 89.409 Section 89.409... Data logging. (a) A computer or any other automatic data processing device(s) may be used as long as the system meets the requirements of this subpart. (b) Determine from the data collection records...

  13. 40 CFR 90.412 - Data logging.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Data logging. 90.412 Section 90.412....412 Data logging. (a) A computer or any other automatic data collection (ADC) device(s) may be used as long as the system meets the requirements of this subpart. (b) Determine from the data...

  14. 40 CFR 89.409 - Data logging.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 20 2011-07-01 2011-07-01 false Data logging. 89.409 Section 89.409... Data logging. (a) A computer or any other automatic data processing device(s) may be used as long as the system meets the requirements of this subpart. (b) Determine from the data collection records...

  15. 40 CFR 89.409 - Data logging.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Data logging. 89.409 Section 89.409... Data logging. (a) A computer or any other automatic data processing device(s) may be used as long as the system meets the requirements of this subpart. (b) Determine from the data collection records...

  16. 40 CFR 90.412 - Data logging.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 20 2011-07-01 2011-07-01 false Data logging. 90.412 Section 90.412....412 Data logging. (a) A computer or any other automatic data collection (ADC) device(s) may be used as long as the system meets the requirements of this subpart. (b) Determine from the data...

  17. 40 CFR 91.412 - Data logging.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 20 2011-07-01 2011-07-01 false Data logging. 91.412 Section 91.412... EMISSIONS FROM MARINE SPARK-IGNITION ENGINES Gaseous Exhaust Test Procedures § 91.412 Data logging. (a) A computer or any other automatic data collection (ADC) device(s) may be used as long as the system meets...

  18. 40 CFR 89.409 - Data logging.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 21 2013-07-01 2013-07-01 false Data logging. 89.409 Section 89.409... Data logging. (a) A computer or any other automatic data processing device(s) may be used as long as the system meets the requirements of this subpart. (b) Determine from the data collection records...

  19. 40 CFR 91.412 - Data logging.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 21 2013-07-01 2013-07-01 false Data logging. 91.412 Section 91.412... EMISSIONS FROM MARINE SPARK-IGNITION ENGINES Gaseous Exhaust Test Procedures § 91.412 Data logging. (a) A computer or any other automatic data collection (ADC) device(s) may be used as long as the system meets...

  20. 40 CFR 91.412 - Data logging.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 21 2012-07-01 2012-07-01 false Data logging. 91.412 Section 91.412... EMISSIONS FROM MARINE SPARK-IGNITION ENGINES Gaseous Exhaust Test Procedures § 91.412 Data logging. (a) A computer or any other automatic data collection (ADC) device(s) may be used as long as the system meets...

  1. 40 CFR 90.412 - Data logging.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 21 2012-07-01 2012-07-01 false Data logging. 90.412 Section 90.412....412 Data logging. (a) A computer or any other automatic data collection (ADC) device(s) may be used as long as the system meets the requirements of this subpart. (b) Determine from the data...

  2. 40 CFR 90.412 - Data logging.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 21 2013-07-01 2013-07-01 false Data logging. 90.412 Section 90.412....412 Data logging. (a) A computer or any other automatic data collection (ADC) device(s) may be used as long as the system meets the requirements of this subpart. (b) Determine from the data...

  3. 40 CFR 91.412 - Data logging.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Data logging. 91.412 Section 91.412... EMISSIONS FROM MARINE SPARK-IGNITION ENGINES Gaseous Exhaust Test Procedures § 91.412 Data logging. (a) A computer or any other automatic data collection (ADC) device(s) may be used as long as the system meets...

  4. 40 CFR 89.409 - Data logging.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 20 2014-07-01 2013-07-01 true Data logging. 89.409 Section 89.409... Data logging. (a) A computer or any other automatic data processing device(s) may be used as long as the system meets the requirements of this subpart. (b) Determine from the data collection records...

  5. 40 CFR 91.412 - Data logging.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 20 2014-07-01 2013-07-01 true Data logging. 91.412 Section 91.412... EMISSIONS FROM MARINE SPARK-IGNITION ENGINES Gaseous Exhaust Test Procedures § 91.412 Data logging. (a) A computer or any other automatic data collection (ADC) device(s) may be used as long as the system meets...

  6. Learning Logs in Introductory Literature Courses

    ERIC Educational Resources Information Center

    Babcock, Matthew James

    2007-01-01

    This article explores the beneficial and sometimes unpredictable implications of a daily reflective writing exercise for introductory literature courses: the learning log. Pseudonymous samples of student writing, coupled with instructor commentary, gesture toward ways in which the learning log's continual implementation and modification foster a…

  7. Improve reliability with operator log sheets

    SciTech Connect

    Devender, A.V.; Ganesan, S.T.

    1996-01-01

    Recently, there have been significant improvements in computerized vibration and online performance monitoring systems. However, despite all the developments, the importance of monitoring rotating equipment through operator log sheets must not be overlooked or neglected. Operator log sheets filled out during shifts can be very useful tools in detecting problems early, provided they are diligently completed and evaluated during the operating shift. In most cases, performance deviations can be corrected by measured within the control of the operator. If the operator understands the purpose of log sheets, and knows the cause and effect of deviations in operating parameters, he or she will be motivated to complete the log sheets to increase equipment reliability. Logged data should include any operating data from equipment that reveals its mechanical condition or performance. The most common data logged are pressure, temperature, flow, power and vibration. The purposes of log sheets are to: establish and recognize the normal operating parameters and identify deviations in performance data; perform timely corrective actions on deviations to avoid unplanned shutdowns and catastrophic failures; avoid repetitive failures and increase mean time between failures; and provide base line data for troubleshooting. Two case histories are presented to illustrate the usefulness of logs: a compressor thrust bearing problem and steam turbine blade washing.

  8. 10 CFR 34.71 - Utilization logs.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Utilization logs. 34.71 Section 34.71 Energy NUCLEAR REGULATORY COMMISSION LICENSES FOR INDUSTRIAL RADIOGRAPHY AND RADIATION SAFETY REQUIREMENTS FOR INDUSTRIAL RADIOGRAPHIC OPERATIONS Recordkeeping Requirements § 34.71 Utilization logs. (a) Each licensee shall...

  9. Discover Presidential Log Cabins. Teacher's Discussion Guide.

    ERIC Educational Resources Information Center

    National Park Service (Dept. of Interior), Washington, DC.

    Discover Presidential Log Cabins is a set of materials designed to help educate 6-8 grade students about the significance of three log cabin sites occupied by George Washington, Ulysses Grant, Abraham Lincoln, and Theodore Roosevelt. This teacher's discussion guide is intended for use as part of a larger, comprehensive social studies program, and…

  10. Selective Logging in the Brazilian Amazon

    NASA Astrophysics Data System (ADS)

    Asner, Gregory P.; Knapp, David E.; Broadbent, Eben N.; Oliveira, Paulo J. C.; Keller, Michael; Silva, Jose N.

    2005-10-01

    Amazon deforestation has been measured by remote sensing for three decades. In comparison, selective logging has been mostly invisible to satellites. We developed a large-scale, high-resolution, automated remote-sensing analysis of selective logging in the top five timber-producing states of the Brazilian Amazon. Logged areas ranged from 12,075 to 19,823 square kilometers per year (+/-14%) between 1999 and 2002, equivalent to 60 to 123% of previously reported deforestation area. Up to 1200 square kilometers per year of logging were observed on conservation lands. Each year, 27 million to 50 million cubic meters of wood were extracted, and a gross flux of ~0.1 billion metric tons of carbon was destined for release to the atmosphere by logging.

  11. Coal-log pipeline system development

    SciTech Connect

    Liu, H.

    1991-12-01

    Project tasks include: (1) Perform the necessary testing and development to demonstrate that the amount of binder in coal logs can be reduced to 8% or lower to produce logs with adequate strength to eliminate breakage during pipeline transportation, under conditions experienced in long distance pipeline systems. Prior to conducting any testing and demonstration, grantee shall perform an information search and make full determination of all previous attempts to extrude or briquette coal, upon which the testing and demonstration shall be based. (2) Perform the necessary development to demonstrate a small model of the most promising injection system for coal-logs, and tests the logs produced. (3) Conduct economic analysis of coal-log pipeline, based upon the work to date. Refine and complete the economic model. (VC)

  12. Designing and Piloting a Leadership Daily Practice Log: Using Logs to Study the Practice of Leadership

    ERIC Educational Resources Information Center

    Spillane, James P.; Zuberi, Anita

    2009-01-01

    Purpose: This article aims to validate the Leadership Daily Practice (LDP) log, an instrument for conducting research on leadership in schools. Research Design: Using a combination of data sources--namely, a daily practice log, observations, and open-ended cognitive interviews--the authors evaluate the validity of the LDP log. Participants: Formal…

  13. The dynamics of the MBP-MalFGK(2) interaction: a prototype for binding protein dependent ABC-transporter systems.

    PubMed

    Shilton, Brian H

    2008-09-01

    This review is focused on the interaction between maltose binding protein (MBP) and the maltose transporter complex, MalFGK(2), which is a member of the ATP Binding Cassette (ABC) superfamily. The interaction between MBP and MalFGK(2) has a critical role in maltose transport, but a coherent description of the interaction is complicated because both MBP and MalFGK(2) can adopt multiple conformations. Drawing on genetic, structural, and biochemical data, the different conformations of MBP and MalFGK(2) are described and incorporated into a model for their interaction. The most important feature of this model is that ligand-bound MBP initiates the process of ATP-dependent maltose transport by stabilizing a high-energy conformation of MalFGK(2). In this model of the MBP-MalFGK(2) interaction, stabilization of a high-energy conformation of MalFGK(2) allows ATP to drive conformational changes in the system - in particular the opening of bound MBP - that leads to formation of a transition state for ATP hydrolysis. Such a role for ligand-bound MBP explains how MBP-independent MalFGK(2) mutants work, and represents a general mechanism for binding-protein dependent ABC import systems. In ABC export systems, which do not use a binding protein, the substrate itself is expected to play a role similar to ligand-bound MBP in the maltose transport system. The mechanistic model for the maltose transporter suggests that ABC-type import systems evolved to make use of a peripheral binding protein so that the transport process is essentially irreversible. PMID:17950243

  14. Une localisation exceptionnelle de la tuberculose vertébrale Mal de Pott sous-occipital

    PubMed Central

    Yahyaoui, Sana; Majdoub, Senda; Zaghouani, Houneida; Fradj, Hosni Ben; Bakir, Dejla; Bouajina, Elyes; Kraiem, Chakib

    2013-01-01

    Le mal de Pott est la forme la plus commune de la tuberculose osseuse touchant essentiellement le rachis dorso-lombaire. La localisation sous-occipitale reste exceptionnelle. Le diagnostic de cette entité est le plus souvent tardif ce qui expose à des complications graves. Les radiographies standard ne sont parlantes qu’à un stade tardif de la maladie, d'où l'intérêt de l'imagerie moderne notamment la tomodensitométrie (TDM) et l'imagerie par résonance magnétique (IRM) qui permettent un diagnostic précoce. Nous rapportons un nouveau cas de tuberculose sous-occipitale. Le diagnostic était posé sur l'imagerie en coupe et confirmé histologiquement à la biopsie transorale. Sont rappelés les aspects en imagerie de cette localisation particulière du mal de Pott. PMID:23819005

  15. SmartMal: a service-oriented behavioral malware detection framework for mobile devices.

    PubMed

    Wang, Chao; Wu, Zhizhong; Li, Xi; Zhou, Xuehai; Wang, Aili; Hung, Patrick C K

    2014-01-01

    This paper presents SmartMal--a novel service-oriented behavioral malware detection framework for vehicular and mobile devices. The highlight of SmartMal is to introduce service-oriented architecture (SOA) concepts and behavior analysis into the malware detection paradigms. The proposed framework relies on client-server architecture, the client continuously extracts various features and transfers them to the server, and the server's main task is to detect anomalies using state-of-art detection algorithms. Multiple distributed servers simultaneously analyze the feature vector using various detectors and information fusion is used to concatenate the results of detectors. We also propose a cycle-based statistical approach for mobile device anomaly detection. We accomplish this by analyzing the users' regular usage patterns. Empirical results suggest that the proposed framework and novel anomaly detection algorithm are highly effective in detecting malware on Android devices. PMID:25165729

  16. Does Information Contained in Systems Logs at Colleges and Universities Constitute Education Records?

    ERIC Educational Resources Information Center

    Rezmierski, Virginia E.; Seese, Marshall R., Jr.

    2002-01-01

    Describes a study of the logging and monitoring activities of college and university system administrators, and its recommendations for handling log data. Reviews the Family Educational Rights and Privacy Act (FERPA). Discusses whether study results are consistent FERPA. Addresses the potential impact of the USA Patriot Act on university…

  17. Coal log pipeline pilot plant study

    SciTech Connect

    Liu, H.; Lenau, C.W.; Burkett, W.

    2000-07-01

    After 8 years of extensive R and D in the new technology of coal log pipeline (CLP), a pilot plant is being built to demonstrate and test a complete CLP system for coal transportation. The system consists of a coal log fabrication plant, a 3,000-ft-length, 6-inch-diameter underground pipeline loop to transport 5.4-inch diameter coal logs, a log injection/ejection system, a pump bypass, a reservoir that serves as both the intake and the outlet of the CLP systems, an instrumentation system that includes pressure transducers, coal log sensors, and flowmeters, and an automatic control system that includes PLCs and a central computer. The pilot plant is to be completed in May of Year 2000. Upon completion of construction, the pilot plant will be used for running various types of coal, testing the degradation rate of drag reduction in CLP using Polyox (polyethylene oxide), testing the reliability of a special coal log sensor invented at the University of Missouri, testing the reliability and the efficiency of the pump-bypass system for pumping coal log trains through the pipe, and testing various hardware components and software for operating the pilot plant. Data collected from the tests will be used for designing future commercial systems of CLP. The pilot plant experiments are to be completed in two years. Then, the technology of CLP will be ready for commercial use.

  18. Recognizing Patterns In Log-Polar Coordinates

    NASA Technical Reports Server (NTRS)

    Weiman, Carl F. R.

    1992-01-01

    Log-Hough transform is basis of improved method for recognition of patterns - particularly, straight lines - in noisy images. Takes advantage of rotational and scale invariance of mapping from Cartesian to log-polar coordinates, and offers economy of representation and computation. Unification of iconic and Hough domains simplifies computations in recognition and eliminates erroneous quantization of slopes attributable to finite spacing of Cartesian coordinate grid of classical Hough transform. Equally efficient recognizing curves. Log-Hough transform more amenable to massively parallel computing architectures than traditional Cartesian Hough transform. "In-place" nature makes it possible to apply local pixel-neighborhood processing.

  19. Nonblocking and orphan free message logging protocols

    NASA Technical Reports Server (NTRS)

    Alvisi, Lorenzo; Hoppe, Bruce; Marzullo, Keith

    1992-01-01

    Currently existing message logging protocols demonstrate a classic pessimistic vs. optimistic tradeoff. We show that the optimistic-pessimistic tradeoff is not inherent to the problem of message logging. We construct a message-logging protocol that has the positive features of both optimistic and pessimistic protocol: our protocol prevents orphans and allows simple failure recovery; however, it requires no blocking in failure-free runs. Furthermore, this protocol does not introduce any additional message overhead as compared to one implemented for a system in which messages may be lost but processes do not crash.

  20. Efficient Preprocessing technique using Web log mining

    NASA Astrophysics Data System (ADS)

    Raiyani, Sheetal A.; jain, Shailendra

    2012-11-01

    Web Usage Mining can be described as the discovery and Analysis of user access pattern through mining of log files and associated data from a particular websites. No. of visitors interact daily with web sites around the world. enormous amount of data are being generated and these information could be very prize to the company in the field of accepting Customerís behaviors. In this paper a complete preprocessing style having data cleaning, user and session Identification activities to improve the quality of data. Efficient preprocessing technique one of the User Identification which is key issue in preprocessing technique phase is to identify the Unique web users. Traditional User Identification is based on the site structure, being supported by using some heuristic rules, for use of this reduced the efficiency of user identification solve this difficulty we introduced proposed Technique DUI (Distinct User Identification) based on IP address ,Agent and Session time ,Referred pages on desired session time. Which can be used in counter terrorism, fraud detection and detection of unusual access of secure data, as well as through detection of regular access behavior of users improve the overall designing and performance of upcoming access of preprocessing results.

  1. Evaluation of historical dry well surveillance logs

    SciTech Connect

    Price, R.K.

    1996-09-09

    Several dry well surveillance logs from 1975 through 1995 for the SX Tank Farm have been examined to identify potential subsurface zones of radioactive contaminant migration. Several dynamic conditions of the gamma-ray emitting radioactive contaminant shave been identified.

  2. 10 CFR 34.71 - Utilization logs.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... RADIOGRAPHIC OPERATIONS Recordkeeping Requirements § 34.71 Utilization logs. (a) Each licensee shall maintain... make, model, and serial number of the radiographic exposure device or transport or storage container...

  3. 10 CFR 34.71 - Utilization logs.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... RADIOGRAPHIC OPERATIONS Recordkeeping Requirements § 34.71 Utilization logs. (a) Each licensee shall maintain... make, model, and serial number of the radiographic exposure device or transport or storage container...

  4. 10 CFR 34.71 - Utilization logs.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... RADIOGRAPHIC OPERATIONS Recordkeeping Requirements § 34.71 Utilization logs. (a) Each licensee shall maintain... make, model, and serial number of the radiographic exposure device or transport or storage container...

  5. 10 CFR 34.71 - Utilization logs.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... RADIOGRAPHIC OPERATIONS Recordkeeping Requirements § 34.71 Utilization logs. (a) Each licensee shall maintain... make, model, and serial number of the radiographic exposure device or transport or storage container...

  6. Logging-while-coring method and apparatus

    DOEpatents

    Goldberg, David S.; Myers, Gregory J.

    2007-11-13

    A method and apparatus for downhole coring while receiving logging-while-drilling tool data. The apparatus includes core collar and a retrievable core barrel. The retrievable core barrel receives core from a borehole which is sent to the surface for analysis via wireline and latching tool The core collar includes logging-while-drilling tools for the simultaneous measurement of formation properties during the core excavation process. Examples of logging-while-drilling tools include nuclear sensors, resistivity sensors, gamma ray sensors, and bit resistivity sensors. The disclosed method allows for precise core-log depth calibration and core orientation within a single borehole, and without at pipe trip, providing both time saving and unique scientific advantages.

  7. Logging-while-coring method and apparatus

    DOEpatents

    Goldberg, David S.; Myers, Gregory J.

    2007-01-30

    A method and apparatus for downhole coring while receiving logging-while-drilling tool data. The apparatus includes core collar and a retrievable core barrel. The retrievable core barrel receives core from a borehole which is sent to the surface for analysis via wireline and latching tool The core collar includes logging-while-drilling tools for the simultaneous measurement of formation properties during the core excavation process. Examples of logging-while-drilling tools include nuclear sensors, resistivity sensors, gamma ray sensors, and bit resistivity sensors. The disclosed method allows for precise core-log depth calibration and core orientation within a single borehole, and without at pipe trip, providing both time saving and unique scientific advantages.

  8. CMLOG: A common message logging system

    SciTech Connect

    Chen, J.; Akers, W.; Bickley, M.; Wu, D.; Watson, W. III

    1997-12-01

    The Common Message Logging (CMLOG) system is an object-oriented and distributed system that not only allows applications and systems to log data (messages) of any type into a centralized database but also lets applications view incoming messages in real-time or retrieve stored data from the database according to selection rules. It consists of a concurrent Unix server that handles incoming logging or searching messages, a Motif browser that can view incoming messages in real-time or display stored data in the database, a client daemon that buffers and sends logging messages to the server, and libraries that can be used by applications to send data to or retrieve data from the database via the server. This paper presents the design and implementation of the CMLOG system meanwhile it will also address the issue of integration of CMLOG into existing control systems.

  9. Sisyphus - An Event Log Analysis Toolset

    SciTech Connect

    Jon Stearley, Glenn Laguna

    2004-09-01

    Event logs are a ubiquitous source of system feedback from computer systems, but have widely ranging format and can be extremely numerous, particularly from systems with many logging components. Inspection of these logs is fundamental to system debugging; increased capability to quickly extract meaningful information will impact MTTR (mean time to repair) and may impact MTBF (mean time between failure). Sisyphus is a machine-leanring analysis system whose goal is to enable content-novice analysts to efficieniiy understand evolving trends, identify anomalies, and investigate cause-effect hypotheses in large multiple-souce log sets. The toolkit is comprised a framework for utilizing third-party frequentitemset data mining tools Teiresias and SLCT. and software to cluster messages according to time statistics, and an interactive results viewer.

  10. Expansion of industrial logging in Central Africa.

    PubMed

    Laporte, Nadine T; Stabach, Jared A; Grosch, Robert; Lin, Tiffany S; Goetz, Scott J

    2007-06-01

    Industrial logging has become the most extensive land use in Central Africa, with more than 600,000 square kilometers (30%) of forest currently under concession. With use of a time series of satellite imagery for the period from 1976 to 2003, we measured 51,916 kilometers of new logging roads. The density of roads across the forested region was 0.03 kilometer per square kilometer, but areas of Gabon and Equatorial Guinea had values over 0.09 kilometer per square kilometer. A new frontier of logging expansion was identified within the Democratic Republic of Congo, which contains 63% of the remaining forest of the region. Tree felling and skid trails increased disturbance in selectively logged areas. PMID:17556578

  11. Sisyphus - An Event Log Analysis Toolset

    2004-09-01

    Event logs are a ubiquitous source of system feedback from computer systems, but have widely ranging format and can be extremely numerous, particularly from systems with many logging components. Inspection of these logs is fundamental to system debugging; increased capability to quickly extract meaningful information will impact MTTR (mean time to repair) and may impact MTBF (mean time between failure). Sisyphus is a machine-leanring analysis system whose goal is to enable content-novice analysts to efficieniiymore » understand evolving trends, identify anomalies, and investigate cause-effect hypotheses in large multiple-souce log sets. The toolkit is comprised a framework for utilizing third-party frequentitemset data mining tools Teiresias and SLCT. and software to cluster messages according to time statistics, and an interactive results viewer.« less

  12. Optimal message log reclamation for uncoordinated checkpointing

    NASA Technical Reports Server (NTRS)

    Wang, Yi-Min; Fuchs, W. K.

    1994-01-01

    Uncoordinated checkpointing for message-passing systems allows maximum process autonomy and general nondeterministic execution, but suffers from potential domino effect and the large space overhead for maintaining checkpoints and message logs. Traditionally, it has been assumed that only obsolete checkpoints and message logs before the global recovery line can be garbage-collected. Recently, an approach to identifying all garbage checkpoints based on recovery line transformation and decomposition has been developed. We show in this paper that the same approach can be applied to the problem of identifying all garbage message logs for systems requiring message logging to record in-transit messages. Communication trace-driven simulation for several parallel programs is used to evaluate the proposed algorithm.

  13. Conversation Threads Hidden within Email Server Logs

    NASA Astrophysics Data System (ADS)

    Palus, Sebastian; Kazienko, Przemysław

    Email server logs contain records of all email Exchange through this server. Often we would like to analyze those emails not separately but in conversation thread, especially when we need to analyze social network extracted from those email logs. Unfortunately each mail is in different record and those record are not tided to each other in any obvious way. In this paper method for discussion threads extraction was proposed together with experiments on two different data sets - Enron and WrUT..

  14. 3D GPR Imaging of Wooden Logs

    NASA Astrophysics Data System (ADS)

    Halabe, Udaya B.; Pyakurel, Sandeep

    2007-03-01

    There has been a lack of an effective NDE technique to locate internal defects within wooden logs. The few available elastic wave propagation based techniques are limited to predicting E values. Other techniques such as X-rays have not been very successful in detecting internal defects in logs. If defects such as embedded metals could be identified before the sawing process, the saw mills could significantly increase their production by reducing the probability of damage to the saw blade and the associated downtime and the repair cost. Also, if the internal defects such as knots and decayed areas could be identified in logs, the sawing blade can be oriented to exclude the defective portion and optimize the volume of high valued lumber that can be obtained from the logs. In this research, GPR has been successfully used to locate internal defects (knots, decays and embedded metals) within the logs. This paper discusses GPR imaging and mapping of the internal defects using both 2D and 3D interpretation methodology. Metal pieces were inserted in a log and the reflection patterns from these metals were interpreted from the radargrams acquired using 900 MHz antenna. Also, GPR was able to accurately identify the location of knots and decays. Scans from several orientations of the log were collected to generate 3D cylindrical volume. The actual location of the defects showed good correlation with the interpreted defects in the 3D volume. The time/depth slices from 3D cylindrical volume data were useful in understanding the extent of defects inside the log.

  15. Salvage logging, ecosystem processes, and biodiversity conservation.

    PubMed

    Lindenmayer, D B; Noss, R F

    2006-08-01

    We summarize the documented and potential impacts of salvage logging--a form of logging that removes trees and other biological material from sites after natural disturbance. Such operations may reduce or eliminate biological legacies, modify rare postdisturbance habitats, influence populations, alter community composition, impair natural vegetation recovery, facilitate the colonization of invasive species, alter soil properties and nutrient levels, increase erosion, modify hydrological regimes and aquatic ecosystems, and alter patterns of landscape heterogeneity These impacts can be assigned to three broad and interrelated effects: (1) altered stand structural complexity; (2) altered ecosystem processes and functions; and (3) altered populations of species and community composition. Some impacts may be different from or additional to the effects of traditional logging that is not preceded by a large natural disturbance because the conditions before, during, and after salvage logging may differ from those that characterize traditional timber harvesting. The potential impacts of salvage logging often have been overlooked, partly because the processes of ecosystem recovery after natural disturbance are still poorly understood and partly because potential cumulative effects of natural and human disturbance have not been well documented. Ecologically informed policies regarding salvage logging are needed prior to major natural disturbances so that when they occur ad hoc and crisis-mode decision making can be avoided. These policies should lead to salvage-exemption zones and limits on the amounts of disturbance-derived biological legacies (e.g., burned trees, logs) that are removed where salvage logging takes place. Finally, we believe new terminology is needed. The word salvage implies that something is being saved or recovered, whereas from an ecological perspective this is rarely the case. PMID:16922212

  16. Selective Logging, Fire, and Biomass in Amazonia

    NASA Technical Reports Server (NTRS)

    Houghton, R. A.

    1999-01-01

    Biomass and rates of disturbance are major factors in determining the net flux of carbon between terrestrial ecosystems and the atmosphere, and neither of them is well known for most of the earth's surface. Satellite data over large areas are beginning to be used systematically to measure rates of two of the most important types of disturbance, deforestation and reforestation, but these are not the only types of disturbance that affect carbon storage. Other examples include selective logging and fire. In northern mid-latitude forests, logging and subsequent regrowth of forests have, in recent decades, contributed more to the net flux of carbon between terrestrial ecosystems and the atmosphere than any other type of land use. In the tropics logging is also becoming increasingly important. According to the FAO/UNEP assessment of tropical forests, about 25% of total area of productive forests have been logged one or more times in the 60-80 years before 1980. The fraction must be considerably greater at present. Thus, deforestation by itself accounts for only a portion of the emissions carbon from land. Furthermore, as rates of deforestation become more accurately measured with satellites, uncertainty in biomass will become the major factor accounting for the remaining uncertainty in estimates of carbon flux. An approach is needed for determining the biomass of terrestrial ecosystems. 3 Selective logging is increasingly important in Amazonia, yet it has not been included in region-wide, satellite-based assessments of land-cover change, in part because it is not as striking as deforestation. Nevertheless, logging affects terrestrial carbon storage both directly and indirectly. Besides the losses of carbon directly associated with selective logging, logging also increases the likelihood of fire.

  17. 32 CFR 700.845 - Maintenance of logs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Commanding Officers Afloat § 700.845 Maintenance of logs. (a) A deck log and an engineering log shall be... bell book shall be maintained as an adjunct to the engineering log. (c) The Chief of Naval Operations shall prescribe regulations governing the contents and preparation of the deck and engineering logs...

  18. 29 CFR 42.7 - Complaint/directed action logs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Complaint/directed action logs. 42.7 Section 42.7 Labor Office of the Secretary of Labor COORDINATED ENFORCEMENT § 42.7 Complaint/directed action logs. (a) To... operation of a system of coordinated Complaint/Directed Action Logs (logs). The logs shall be maintained...

  19. 29 CFR 42.7 - Complaint/directed action logs.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 1 2011-07-01 2011-07-01 false Complaint/directed action logs. 42.7 Section 42.7 Labor Office of the Secretary of Labor COORDINATED ENFORCEMENT § 42.7 Complaint/directed action logs. (a) To... operation of a system of coordinated Complaint/Directed Action Logs (logs). The logs shall be maintained...

  20. Data Mining in the SIMBAD Database Web Log Files

    NASA Astrophysics Data System (ADS)

    Wenger, M.; Oberto, A.

    2010-12-01

    The SIMBAD web server generates log records for every query. In the last years, the number of queries increased from 30,000 to 200,000 queries per day. This gives a good basis to make some data mining among this information. Using the available data, and a database of geolocalisation by IP address, we can find many unusual results: from session duration to preferred working hours in countries and the most and less active countries in astronomy.

  1. MyD88 adaptor-like (Mal) functions in the epithelial barrier and contributes to intestinal integrity via protein kinase C.

    PubMed

    Corr, S C; Palsson-McDermott, E M; Grishina, I; Barry, S P; Aviello, G; Bernard, N J; Casey, P G; Ward, J B J; Keely, S J; Dandekar, S; Fallon, P G; O'Neill, L A J

    2014-01-01

    MyD88 adapter-like (Mal)-deficient mice displayed increased susceptibility to oral but not intraperitoneal infection with Salmonella Typhimurium. Bone marrow chimeras demonstrated that mice with Mal-deficient non-hematopoietic cells were more susceptible to infection, indicating a role for Mal in non-myeloid cells. We observed perturbed barrier function in Mal(-/-) mice, as indicated by reduced electrical resistance and increased mucosa blood permeability following infection. Altered expression of occludin, Zonula occludens-1, and claudin-3 in intestinal epithelia from Mal(-/-) mice suggest that Mal regulates tight junction formation, which may in part contribute to intestinal integrity. Mal interacted with several protein kinase C (PKC) isoforms in a Caco-2 model of intestinal epithelia and inhibition of Mal or PKC increased permeability and bacterial invasion via a paracellular route, while a pan-PKC inhibitor increased susceptibility to oral infection in mice. Mal signaling is therefore beneficial to the integrity of the intestinal barrier during infection. PMID:23612054

  2. On-site assessment of rock discontinuities from resistivity logs. T-L log: A new logging technique

    NASA Astrophysics Data System (ADS)

    Tselentis, Gerasimos-Akis

    1986-03-01

    The direct on-site assessment of the vertical distribution of discontinuities to rock masses is very important since it can give a first estimation of the hydraulic properties of the strata and has many practical applications, such as groundwater resources investigations, radioactive and toxic waste disposal, dam foundation site investigations, etc. In the present work, the effect that fractures have upon some geophysical parameters which can easily be determined from the analysis of conventional normal resistivity logs is examined and a new technique for the on-site processing of resistivity logging data is introduced. Using a microcomputer in series with the logging unit, a zonation process was applied to the logs, which were interpreted in terms of a series of beds, each having a specific thickness and resistivity, and a new parameter defined by the difference between transverse and longitudinal resistivities was computed (T-L log). In almost all the cases that the method was applied, the obtained results were satisfactory and the microcomputer-based software and hardware package that was developed for the automatic processing of the data proved to be very efficient.

  3. Carbon emissions performance of commercial logging in East Kalimantan, Indonesia.

    PubMed

    Griscom, Bronson; Ellis, Peter; Putz, Francis E

    2014-03-01

    Adoption of reduced-impact logging (RIL) methods could reduce CO2 emissions by 30-50% across at least 20% of remaining tropical forests. We developed two cost effective and robust indices for comparing the climate benefits (reduced CO2 emissions) due to RIL. The indices correct for variability in the volume of commercial timber among concessions. We determined that a correction for variability in terrain slope was not needed. We found that concessions certified by the Forest Stewardship Council (FSC, N = 3), when compared with noncertified concessions (N = 6), did not have lower overall CO2 emissions from logging activity (felling, skidding, and hauling). On the other hand, FSC certified concessions did have lower emissions from one type of logging impact (skidding), and we found evidence of a range of improved practices using other field metrics. One explanation of these results may be that FSC criteria and indicators, and associated RIL practices, were not designed to achieve overall emissions reductions. Also, commonly used field metrics are not reliable proxies for overall logging emissions performance. Furthermore, the simple distinction between certified and noncertified concessions does not fully represent the complex history of investments in improved logging practices. To clarify the relationship between RIL and emissions reductions, we propose the more explicit term 'RIL-C' to refer to the subset of RIL practices that can be defined by quantified thresholds and that result in measurable emissions reductions. If tropical forest certification is to be linked with CO2 emissions reductions, certification standards need to explicitly require RIL-C practices. PMID:24022913

  4. 55. VIEW OF STEAMOPERATED LOG HOIST TO PUT IN COMING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    55. VIEW OF STEAM-OPERATED LOG HOIST TO PUT IN COMING LOGS INTO RALPH HULL LUMBER CO. LOG POND. PHOTOGRAPHER: UNKNOWN. DATE: 1942. COURTESY OF RALPH HULL. - Hull-Oakes Lumber Company, 23837 Dawson Road, Monroe, Benton County, OR

  5. 5. Log calving barn. Detail of wall corner showing half ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Log calving barn. Detail of wall corner showing half dovetail notching on hand-hewn logs. - William & Lucina Bowe Ranch, Log Calving Barn, 230 feet south-southwest of House, Melrose, Silver Bow County, MT

  6. 32 CFR 700.846 - Status of logs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... OFFICIAL RECORDS UNITED STATES NAVY REGULATIONS AND OFFICIAL RECORDS The Commanding Officer Commanding Officers Afloat § 700.846 Status of logs. The deck log, the engineering log, the compass record,...

  7. 32 CFR 700.846 - Status of logs.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... OFFICIAL RECORDS UNITED STATES NAVY REGULATIONS AND OFFICIAL RECORDS The Commanding Officer Commanding Officers Afloat § 700.846 Status of logs. The deck log, the engineering log, the compass record,...

  8. Deep penetration well logging system and method

    SciTech Connect

    Cox, P.T.; Warren, W.F.; Johnson, D.L.

    1990-01-30

    This patent describes a well logging system for determining the dielectric constant and/or resistivity of earth formations, some of which have been invaded by drilling fluid, traversed by a borehole. It comprises: a well logging sonde adapted to be passed through the borehole including: means for transmitting electromagnetic energy into the earth formation at a frequency which enables the electromagnetic energy to propagate throughout the surrounding earth formation; first, second and third receiver means; means connected to the three receiver means for processing the three receiver signals to provide a combined signal for application to well logging cable means, well logging cable means for conducting the combined signal from the signal processing means out of the borehole; and surface electronics. The surface electronics includes indication means connected to the well logging cable means for providing an indication of the dielectric constant and/or the resistivity of the earth formation in accordance with portions of the combined signal conducted by the cable means representative of secondary electromagnetic fields at two of the three receiving means locations.

  9. Logjam: A scalable unified log file archiver

    2001-08-01

    Log files are a necessary record of events on any system. However, as systems scale, so does the volume of data captured. To complicate matters, this data can be distributed across all nodes within the system. This creates challenges in ways to obtain these files as well as archiving them in a consistent manner. It has become commonplace to develop a custom written utility for each system that is tailored specifically to that system. Formore » computer centers that contain multiple systems, each system would have their own respective utility for gathering and archiving log files. Each time a new log file is produced, a modification to the utility is necessary. With each modification, risks of errors could be introduced as well as spending time to introduce that change. This is precisely the purpose of logjam. Once installed, the code only requires modification when new features are required. A configuration file is used to identify each log file as well as where to harvest it and how to archive it. Adding a new log file is as simple as defining it in a configuration file and testing can be performed in the production environment.« less

  10. Logjam: A scalable unified log file archiver

    SciTech Connect

    Cardo, Nicholas P.

    2001-08-01

    Log files are a necessary record of events on any system. However, as systems scale, so does the volume of data captured. To complicate matters, this data can be distributed across all nodes within the system. This creates challenges in ways to obtain these files as well as archiving them in a consistent manner. It has become commonplace to develop a custom written utility for each system that is tailored specifically to that system. For computer centers that contain multiple systems, each system would have their own respective utility for gathering and archiving log files. Each time a new log file is produced, a modification to the utility is necessary. With each modification, risks of errors could be introduced as well as spending time to introduce that change. This is precisely the purpose of logjam. Once installed, the code only requires modification when new features are required. A configuration file is used to identify each log file as well as where to harvest it and how to archive it. Adding a new log file is as simple as defining it in a configuration file and testing can be performed in the production environment.

  11. Seasonal logging, process response, and geomorphic work

    NASA Astrophysics Data System (ADS)

    Mohr, C.; Zimmermann, A.; Korup, O.; Iroume, A.; Francke, T.; Bronstert, A.

    2013-12-01

    Deforestation is a prominent anthropogenic cause of erosive overland flow and slope instability, boosting rates of soil erosion and concomitant sediment flux. Conventional methods of gauging or estimating post-logging sediment flux focus on annual timescales, but overlook potentially important process response on shorter intervals immediately following timber harvest. We resolve such dynamics from non-parametric Quantile Regression Forests (QRF) of high-frequency (3-min) measurements of stream discharge and sediment concentrations in similar-sized (~0.1 km2) forested Chilean catchments that were logged during either the rainy or the dry season. The method of QRF builds on the Random Forest algorithm, and combines quantile regression with repeated random sub-sampling of both cases and predictors which in turn provides model uncertainties. We find that, where no logging occurred, ~80% of the total sediment load was transported during extremely variable runoff events during only 5% of the monitoring period. Particularly dry-season logging dampened the role of these rare, extreme sediment-transport events by increasing load efficiency during more efficient moderate events. We conclude that QRF may reliably support forest management recommendations by providing robust simulations of post-logging response of water and sediment fluxes at high temporal resolution.

  12. Structure of the conserved hypothetical protein MAL13P1.257 from Plasmodium falciparum

    PubMed Central

    Holmes, Margaret A.; Buckner, Frederick S.; Van Voorhis, Wesley C.; Mehlin, Christopher; Boni, Erica; Earnest, Thomas N.; DeTitta, George; Luft, Joseph; Lauricella, Angela; Anderson, Lori; Kalyuzhniy, Oleksandr; Zucker, Frank; Schoenfeld, Lori W.; Hol, Wim G. J.; Merritt, Ethan A.

    2006-01-01

    The structure of a conserved hypothetical protein, PlasmoDB sequence MAL13P1.257 from Plasmodium falciparum, Pfam sequence family PF05907, has been determined as part of the structural genomics effort of the Structural Genomics of Pathogenic Protozoa consortium. The structure was determined by multiple-wavelength anomalous dispersion at 2.17 Å resolution. The structure is almost entirely β-sheet; it consists of 15 β-strands and one short 310-helix and represents a new protein fold. The packing of the two monomers in the asymmetric unit indicates that the biological unit may be a dimer. PMID:16511296

  13. Spreadsheet log analysis in subsurface geology

    USGS Publications Warehouse

    Doveton, J.H.

    2000-01-01

    Most of the direct knowledge of the geology of the subsurface is gained from the examination of core and drill-cuttings recovered from boreholes drilled by the petroleum and water industries. Wireline logs run in these same boreholes generally have been restricted to tasks of lithostratigraphic correlation and thee location of hydrocarbon pay zones. However, the range of petrophysical measurements has expanded markedly in recent years, so that log traces now can be transformed to estimates of rock composition. Increasingly, logs are available in a digital format that can be read easily by a desktop computer and processed by simple spreadsheet software methods. Taken together, these developments offer accessible tools for new insights into subsurface geology that complement the traditional, but limited, sources of core and cutting observations.

  14. Log-rolling block copolymers cylinders

    NASA Astrophysics Data System (ADS)

    Kim, So Youn; Kim, Ye Chan; Kim, Dong Hyup; Kwon, Na Kyung; Register, Richard A.

    Shear has been the most effective method to create long range order of micro- or nano- structures in soft materials. When shear is applied, soft particles or polymers tend to align along the shear direction to minimize the viscous dissipation, thus transverse (so-called ``log-rolling'') alignment is unfavored. In this study, for the first time we report the transverse alignment of cylinder-forming block copolymers. Poly(styrene-b-methyl methacrylate), PS-PMMA, can form a metastable hemicylinder structure when confined in a thin film, and this hemicylinder structure can align either along the shear direction, or transverse to the shear direction (``log-rolling''), depending on the shearing temperature. This unusual ``log-rolling'' behavior is explained by the different chain mobility of the two blocks in PS-PMMA; the rigidity of core cylinder is the critical parameter determining the direction of shear alignment.

  15. LogSafe and Smart: Minnesota OSHA's LogSafe Program Takes Root.

    ERIC Educational Resources Information Center

    Honerman, James

    1999-01-01

    Logging is now the most dangerous U.S. occupation. The Occupational Safety and Health Administration (OSHA) developed specialized safety training for the logging industry but has been challenged to reach small operators. An OSHA-approved state program in Minnesota provides annual safety seminars to about two-thirds of the state's full-time…

  16. Lithologic logs and geophysical logs from test drilling in Palm Beach County, Florida, since 1974

    USGS Publications Warehouse

    Swayze, Leo J.; McGovern, Michael C.; Fischer, John N.

    1980-01-01

    Test-hole data that may be used to determine the hydrogeology of the zone of high permeability in Palm Beach County, Fla., are presented. Lithologic logs from 46 test wells and geophysical logs from 40 test wells are contained in this report. (USGS)

  17. Breaking the vicious circle of illegal logging in Indonesia.

    PubMed

    Linkie, Matthew; Sloan, Sean; Kasia, Rahmad; Kiswayadi, Dedy; Azmi, Wahdi

    2014-08-01

    The government of Indonesia, which presides over 10% of the world's tropical forests, has set ambitious targets to cut its high deforestation rates through an REDD+ scheme (Reducing Emissions from Deforestation and forest Degradation). This will require strong law enforcement to succeed. Yet, strategies that have accomplished this are rare and, along with past failures, tend not to be documented. We evaluated a multistakeholder approach that seeks to tackle illegal logging in the carbon-rich province of Aceh, Sumatra. From 2008 to 2009, Fauna & Flora International established and supported a community-based informant network for the 738,000 ha Ulu Masen ecosystem. The network reported 190 forest offenses to local law enforcement agencies, which responded with 86 field operations that confiscated illicit vehicles, equipment, and timber, and arrested 138 illegal logging suspects. From 45 cases subsequently monitored, 64.4% proceeded to court, from which 90.0% of defendants received a prison sentence or a verbal warning for a first offense. Spatial analyses of illegal logging and timber storage incidents predicted that illegal activities would be more effectively deterred by law enforcement operations that targeted the storage sites. Although numerous clusters of incidents were identified, they were still widespread reflecting the ubiquity of illegal activities. The multistakeholder results were promising, but illegal logging still persisted at apparently similar levels at the project's end, indicating that efforts need to be further strengthened. Nevertheless, several actions contributed to the law enforcement achievements: strong political will; strong stakeholder support; and funding that could be promptly accessed. These factors are highlighted as prerequisites for achieving Indonesia's ambitious REDD+ goals. PMID:24628366

  18. Development of pulsed neutron uranium logging instrument

    SciTech Connect

    Wang, Xin-guang; Liu, Dan; Zhang, Feng

    2015-03-15

    This article introduces a development of pulsed neutron uranium logging instrument. By analyzing the temporal distribution of epithermal neutrons generated from the thermal fission of {sup 235}U, we propose a new method with a uranium-bearing index to calculate the uranium content in the formation. An instrument employing a D-T neutron generator and two epithermal neutron detectors has been developed. The logging response is studied using Monte Carlo simulation and experiments in calibration wells. The simulation and experimental results show that the uranium-bearing index is linearly correlated with the uranium content, and the porosity and thermal neutron lifetime of the formation can be acquired simultaneously.

  19. Development of pulsed neutron uranium logging instrument.

    PubMed

    Wang, Xin-guang; Liu, Dan; Zhang, Feng

    2015-03-01

    This article introduces a development of pulsed neutron uranium logging instrument. By analyzing the temporal distribution of epithermal neutrons generated from the thermal fission of (235)U, we propose a new method with a uranium-bearing index to calculate the uranium content in the formation. An instrument employing a D-T neutron generator and two epithermal neutron detectors has been developed. The logging response is studied using Monte Carlo simulation and experiments in calibration wells. The simulation and experimental results show that the uranium-bearing index is linearly correlated with the uranium content, and the porosity and thermal neutron lifetime of the formation can be acquired simultaneously. PMID:25832251

  20. Permeability extraction: A sonic log inversion

    SciTech Connect

    Akbar, N.; Kim, J.J.

    1994-12-31

    In this paper the authors provide the missing important link between permeability and acoustic velocities by generating a permeability-dependent synthetic sonic log in a carbonate reservoir. The computations are based on Akbar`s theory that relates wave velocity to frequency, rock properties (e.g., lithology, permeability, and porosity), and fluid saturation and properties (viscosity, density, and compressibility). An inverted analytical expression of the theory is used to extract permeability from sonic velocity. The synthetic sonic and the computed permeability are compared with the observed sonic log and with plug permeability, respectively. The results demonstrate, as predicted by theory, that permeability can be related directly to acoustic velocities.

  1. MAIL LOG, program summary and specifications

    NASA Technical Reports Server (NTRS)

    Harris, D. K.

    1979-01-01

    The summary and specifications to obtain the software package, MAIL LOG, developed for the Scout Project Automatic Data System, SPADS are provided. The MAIL LOG program has four modes of operation: (1) input - putting new records into the data base; (2) revise - changing or modifying existing records in the data base; (3) search - finding special records existing in the data base; and (4) archive - store or put away existing records in the data base. The output includes special printouts of records in the data base and results from the input and search modes.

  2. Compacting a Kentucky coal for quality logs

    SciTech Connect

    Lin, Y.; Li, Z.; Mao, S.

    1999-07-01

    A Kentucky coal was found more difficult to be compacted into large size strong logs. Study showed that compaction parameters affecting the strength of compacted coal logs could be categorized into three groups. The first group is coal inherent properties such as elasticity and coefficient of friction, the second group is machine properties such as mold geometry, and the third group is the coal mixture preparation parameters such as particle size distribution. Theoretical analysis showed that an appropriate backpressure can reduce surface cracks occurring during ejection. This has been confirmed by the experiments conducted.

  3. Characterization and Functional Analysis of the MAL and MPH Loci for Maltose Utilization in Some Ale and Lager Yeast Strains

    PubMed Central

    Vidgren, Virve; Ruohonen, Laura; Londesborough, John

    2005-01-01

    Maltose and maltotriose are the major sugars in brewer's wort. Brewer's yeasts contain multiple genes for maltose transporters. It is not known which of these express functional transporters. We correlated maltose transport kinetics with the genotypes of some ale and lager yeasts. Maltose transport by two ale strains was strongly inhibited by other α-glucosides, suggesting the use of broad substrate specificity transporters, such as Agt1p. Maltose transport by three lager strains was weakly inhibited by other α-glucosides, suggesting the use of narrow substrate specificity transporters. Hybridization studies showed that all five strains contained complete MAL1, MAL2, MAL3, and MAL4 loci, except for one ale strain, which lacked a MAL2 locus. All five strains also contained both AGT1 (coding a broad specificity α-glucoside transporter) and MAL11 alleles. MPH genes (maltose permease homologues) were present in the lager but not in the ale strains. During growth on maltose, the lager strains expressed AGT1 at low levels and MALx1 genes at high levels, whereas the ale strains expressed AGT1 at high levels and MALx1 genes at low levels. MPHx expression was negligible in all strains. The AGT1 sequences from the ale strains encoded full-length (616 amino acid) polypeptides, but those from both sequenced lager strains encoded truncated (394 amino acid) polypeptides that are unlikely to be functional transporters. Thus, despite the apparently similar genotypes of these ale and lager strains revealed by hybridization, maltose is predominantly carried by AGT1-encoded transporters in the ale strains and by MALx1-encoded transporters in the lager strains. PMID:16332759

  4. The Soufriere Hills Volcano, Montserrat, is "log logistic"

    NASA Astrophysics Data System (ADS)

    Connor, C.; Sparks, S.; Mason, R.; Bonadonna, C.; Young, S.; Lejeune, A.

    2002-12-01

    The Soufriere Hills Volcano, Montserrat, experienced a remarkable episode of activity in September-October, 1997. During this period, 75 vulcanian explosions generated plumes that commonly rose between 5 to 15 km a.s.l. accompanied by pyroclastic flows. Repose intervals between vulcanian explosions varied from 2.77 to 33.7 hrs, with a median repose interval of 9.0 hr and mean of 9.6 hr. During the eruption, this narrow range of repose intervals was used in a practical way to provide qualitative forecasts of volcanic hazard. We analyzed repose intervals for these 75 vulcanian explosions and discovered they fit a log logistic distribution with > 99% confidence. This comparatively simple, two parameter model accounts for departures from a classical material failure model (Weibull distribution) at long repose intervals, and serves as the basis for improved hazard forecasts. The crucial differences between Weibull, and log logistic probability models for volcano repose interval are illustrated by comparing their hazard functions. For Weibull distributions the hazard increases indefinitely: the volcano must erupt explosively eventually and as time increases the probability of an eruption in the next time interval becomes much greater. In contrast the log logistic hazard function goes through a simple maximum. We note that largest magnitude eruptions in the time series, deduced from column height estimates and seismic explosion amplitudes, correlate with the peak in the log logistic hazard function. The excellent model fit is explained in terms of two competing processes operating in the upper conduit on different time scales. Gas bubble pressure increases with time due to exsolution and due to rheological stiffening of magma of magma following an abrupt decompression caused by a previous explosion. Once bubble gas pressure exceeds the tensile strength of the magma an explosion occurs - a material failure model that should follow a Weibull distribution. However, this

  5. MalF is essential for persistence of Mycoplasma gallisepticum in vivo.

    PubMed

    Tseng, Chi-Wen; Kanci, Anna; Citti, Christine; Rosengarten, Renate; Chiu, Chien-Ju; Chen, Zheng-Hong; Geary, Steven J; Browning, Glenn F; Markham, Philip F

    2013-07-01

    There is limited understanding of the molecular basis of virulence in the important avian pathogen Mycoplasma gallisepticum. To define genes that may be involved in colonization of chickens, a collection of mutants of the virulent Ap3AS strain of M. gallisepticum were generated by signature-tagged transposon mutagenesis. The collection included mutants with single insertions in the genes encoding the adhesin GapA and the cytadherence-related protein CrmA, and Western blotting confirmed that these mutants did not express these proteins. In two separate in vivo screenings, two GapA-deficient mutants (ST mutants 02-1 and 06-1) were occasionally recovered from birds, suggesting that GapA expression may not always be essential for persistence of strain Ap3AS. CrmA-deficient ST mutant 33-1 colonized birds poorly and had reduced virulence, indicating that CrmA was a significant virulence factor, but was not absolutely essential for colonization. ST mutant 04-1 contained a single transposon insertion in malF, a predicted ABC sugar transport permease, and could not be reisolated even when inoculated by itself into a group of birds, suggesting that expression of MalF was essential for persistence of M. galliseptium strain Ap3AS in infected birds. PMID:23657682

  6. Methods of Analysis of Enteropathogen Infection in the MAL-ED Cohort Study

    PubMed Central

    Platts-Mills, James A.; McCormick, Benjamin J. J.; Kosek, Margaret; Pan, William K.; Checkley, William; Houpt, Eric R.

    2014-01-01

    Studies of diarrheal etiology in low- and middle-income countries have typically focused on children presenting with severe symptoms to health centers and thus are best equipped to describe the pathogens capable of leading to severe diarrheal disease. The Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) cohort study was designed to evaluate, via intensive community surveillance, the hypothesis that repeated exposure to enteropathogens has a detrimental effect on growth, vaccine response, and cognitive development, which are the primary outcome measures for this study. In the setting of multiple outcomes of interest, a longitudinal cohort design was chosen. Because many or even the majority of enteric infections are asymptomatic, the collection of asymptomatic surveillance stools was a critical element. However, capturing diarrheal stools additionally allowed for the determination of the principle causes of diarrhea at the community level as well as for a comparison between those enteropathogens associated with diarrhea and those that are associated with poor growth, diminished vaccine response, and impaired cognitive development. Here, we discuss the analytical methods proposed for the MAL-ED study to determine the principal causes of diarrhea at the community level and describe the complex interplay between recurrent exposure to enteropathogens and these critical long-term outcomes. PMID:25305292

  7. 1. GENERAL VIEW OF LOG POND AND BOOM FOR UNLOADING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. GENERAL VIEW OF LOG POND AND BOOM FOR UNLOADING CEDAR LOGS FROM TRUCKS AT LOG DUMP, ADJACENT TO MILL; TRUCKS FORMERLY USED TRIP STAKES, THOUGH FOR SAFER HANDLING OF LOGS WELDED STAKES ARE NOW REQUIRED; AS A RESULT LOADING IS NOW DONE WITH A CRANE - Lester Shingle Mill, 1602 North Eighteenth Street, Sweet Home, Linn County, OR

  8. 32 CFR 700.845 - Maintenance of logs.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... AND OFFICIAL RECORDS UNITED STATES NAVY REGULATIONS AND OFFICIAL RECORDS The Commanding Officer Commanding Officers Afloat § 700.845 Maintenance of logs. (a) A deck log and an engineering log shall be... Naval Operations. (b) A compass record shall be maintained as an adjunct to the deck log. An...

  9. Discovering the Local Landscape: Pioneer Log Buildings.

    ERIC Educational Resources Information Center

    Douglas, Bob; And Others

    Building structures made from logs appeared in the eastern United States during the late 17th century, and immigrants from Sweden, Finland, and Germany are credited with their construction. There were two types of structures: the horizontal design introduced by the Scandinavians and the German or Pennsylvania Dutch model that was used by the…

  10. Predicting reservoir wettability via well logs

    NASA Astrophysics Data System (ADS)

    Feng, Cheng; Fu, Jinhua; Shi, Yujiang; Li, Gaoren; Mao, Zhiqiang

    2016-06-01

    Wettability is an important factor in controlling the distribution of oil and water. However, its evaluation has so far been a difficult problem because no log data can directly indicate it. In this paper, a new method is proposed for quantitatively predicting reservoir wettability via well log analysis. Specifically, based on the J function, diagenetic facies classification and the piecewise power functions, capillary pressure curves are constructed from conventional logs and a nuclear magnetic resonance (NMR) log respectively. Under the influence of wettability, the latter is distorted while the former remains unaffected. Therefore, the ratio of the median radius obtained from the two kinds of capillary pressure curve is calculated to reflect wettability, a quantitative relationship between the ratio and reservoir wettability is then established. According to the low-permeability core sample capillary pressure curve, NMR {{T}2} spectrum and contact angle experimental data from the bottom of the Upper Triassic reservoirs in western Ordos Basin, China, two kinds of constructing capillary pressure curve models and a predictive wettability model are calibrated. The wettability model is verified through the Amott wettability index and saturation exponent from resistivity measurement and their determined wettability levels are comparable, indicating that the proposed model is quite reliable. In addition, the model’s good application effect is exhibited in the field study. Thus, the quantitatively predicting reservoir wettability model proposed in this paper provides an effective tool for formation evaluation, field development and the improvement of oil recovery.

  11. There's Life in Those Dead Logs!

    ERIC Educational Resources Information Center

    Biggs, Devin; Miller, Todd; Hall, Dee

    2006-01-01

    Although it is unspectacular in appearance, dead wood is one of the most ecologically important resources in forests. Fallen logs, dead standing trees, stumps, and even cavities in live trees fulfill a wide range of roles. Prominent among these is that they provide habitat for many organisms, especially insects. Fourth-grade students at Fox…

  12. The Design Log: A New Informational Tool

    ERIC Educational Resources Information Center

    Spivak, Mayer

    1978-01-01

    The design log is a record of observations, diagnoses, prescriptions, and performance specifications for each space in a structure. It is a systematic approach to design that integrates information about user needs with traditional architectural programming and design. (Author/MLF)

  13. MAIL LOG, program theory, volume 2

    NASA Technical Reports Server (NTRS)

    Harris, D. K.

    1979-01-01

    Information relevant to the MAIL LOG program theory is documented. The L-files for mail correspondence, design information release/report, and the drawing/engineering order are given. In addition, sources for miscellaneous external routines and special support routines are documented along with a glossary of terms.

  14. 47 CFR 80.409 - Station logs.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... expressed in Coordinated Universal Time (UTC). (2) “ON WATCH” must be entered by the operator beginning a... until the claim or complaint has been satisfied or barred by statute limiting the time for filing suits... log by the operator's signature. (2) The date and time of making an entry must be shown opposite...

  15. 47 CFR 80.409 - Station logs.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... expressed in Coordinated Universal Time (UTC). (2) “ON WATCH” must be entered by the operator beginning a... until the claim or complaint has been satisfied or barred by statute limiting the time for filing suits... log by the operator's signature. (2) The date and time of making an entry must be shown opposite...

  16. 47 CFR 80.409 - Station logs.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... expressed in Coordinated Universal Time (UTC). (2) “ON WATCH” must be entered by the operator beginning a... until the claim or complaint has been satisfied or barred by statute limiting the time for filing suits... log by the operator's signature. (2) The date and time of making an entry must be shown opposite...

  17. OPAC User Logs: Implications for Bibliographic Instruction.

    ERIC Educational Resources Information Center

    Kern-Simirenko, Cheryl

    1983-01-01

    Discusses characteristics of typical online public access catalogs (OPACs) and examines patron use via printouts of transaction logs for three separate systems. Desirable features of OPACs (mnemonic search commands, boolean operators, forgiveness or automatic truncation, browsing a subject heading index, suggestive prompts) and need for…

  18. High temperature spectral gamma well logging

    SciTech Connect

    Normann, R.A.; Henfling, J.A.

    1997-01-01

    A high temperature spectral gamma tool has been designed and built for use in small-diameter geothermal exploration wells. Several engineering judgments are discussed regarding operating parameters, well model selection, and signal processing. An actual well log at elevated temperatures is given with spectral gamma reading showing repeatability.

  19. Rill Erosion in Post Wildfire Forests after Salvage Logging

    NASA Astrophysics Data System (ADS)

    Robichaud, Peter; Wagenbrenner, Joseph; Brown, Robert

    2016-04-01

    Despite the dominance of concentrated flow or rill erosion in the erosion processes especially in steep forest environments that have been affected by wildfire or management activities few studies have quantified these effects on rill erosion. This study quantified the effects of wildfire and post-fire timber salvage operations on rill runoff quantity, runoff velocity, and rill erosion. Simulated rill experiments were conducted at various sites in the Western US after wildfire and timber salvage operations. The onsite conditions consists of burned only, salvage logged, skid or snig trail, or skid trails with extra logging debris added. For each rill experiment, concentrated flow was applied at the top of the plot through an energy dissipater at five inflow rates for 12 min each. Runoff was sampled every 2 min and runoff volume and sediment concentration were determined for each sample. The runoff velocity was measured using a dyed calcium chloride solution and two conductivity probes placed a known distance apart. Runoff volume, runoff velocities, and sediment concentrations increased with increasing levels of disturbance. The burned only plots had lower runoff rates and sediment concentrations than any of the other disturbances. The salvage logged plots had greater responses than the burn only plots and the mitigation treatment had a marginal effect on runoff ratios, runoff velocities and sediment concentrations. These results suggest that additional disturbance after a wildfire can increase the erosional response and that proper erosion control mitigation may be an important consideration for post fire management to reduce onsite erosion.

  20. Requirements-Driven Log Analysis Extended Abstract

    NASA Technical Reports Server (NTRS)

    Havelund, Klaus

    2012-01-01

    Imagine that you are tasked to help a project improve their testing effort. In a realistic scenario it will quickly become clear, that having an impact is diffcult. First of all, it will likely be a challenge to suggest an alternative approach which is significantly more automated and/or more effective than current practice. The reality is that an average software system has a complex input/output behavior. An automated testing approach will have to auto-generate test cases, each being a pair (i; o) consisting of a test input i and an oracle o. The test input i has to be somewhat meaningful, and the oracle o can be very complicated to compute. Second, even in case where some testing technology has been developed that might improve current practice, it is then likely difficult to completely change the current behavior of the testing team unless the technique is obviously superior and does everything already done by existing technology. So is there an easier way to incorporate formal methods-based approaches than the full edged test revolution? Fortunately the answer is affirmative. A relatively simple approach is to benefit from possibly already existing logging infrastructure, which after all is part of most systems put in production. A log is a sequence of events, generated by special log recording statements, most often manually inserted in the code by the programmers. An event can be considered as a data record: a mapping from field names to values. We can analyze such a log using formal methods, for example checking it against a formal specification. This separates running the system for analyzing its behavior. It is not meant as an alternative to testing since it does not address the important in- put generation problem. However, it offers a solution which testing teams might accept since it has low impact on the existing process. A single person might be assigned to perform such log analysis, compared to the entire testing team changing behavior.

  1. Seasonal logging, process response, and geomorphic work

    NASA Astrophysics Data System (ADS)

    Mohr, C. H.; Zimmermann, A.; Korup, O.; Iroumé, A.; Francke, T.; Bronstert, A.

    2013-09-01

    Deforestation is a prominent anthropogenic cause of erosive overland flow and slope instability, boosting rates of soil erosion and concomitant sediment flux. Conventional methods of gauging or estimating post-logging sediment flux focus on annual timescales, but potentially overlook important geomorphic responses on shorter time scales immediately following timber harvest. Sediments fluxes are commonly estimated from linear regression of intermittent measurements of water and sediment discharge using sediment rating curves (SRCs). However, these often unsatisfactorily reproduce non-linear effects such as discharge-load hystereses. We resolve such important dynamics from non-parametric Quantile Regression Forests (QRF) of high-frequency (3 min) measurements of stream discharge and sediment concentrations in similar-sized (~ 0.1 km2) forested Chilean catchments that were logged during either the rainy or the dry season. The method of QRF builds on the Random Forest (RF) algorithm, and combines quantile regression with repeated random sub-sampling of both cases and predictors. The algorithm belongs to the family of decision-tree classifiers, which allow quantifying relevant predictors in high-dimensional parameter space. We find that, where no logging occurred, ~ 80% of the total sediment load was transported during rare but high magnitude runoff events during only 5% of the monitoring period. The variability of sediment flux of these rare events spans four orders of magnitude. In particular dry-season logging dampened the role of these rare, extreme sediment-transport events by increasing load efficiency during more moderate events. We show that QRFs outperforms traditional SRCs in terms of accurately simulating short-term dynamics of sediment flux, and conclude that QRF may reliably support forest management recommendations by providing robust simulations of post-logging response of water and sediment discharge at high temporal resolution.

  2. Seasonal logging, process response, and geomorphic work

    NASA Astrophysics Data System (ADS)

    Mohr, C. H.; Zimmermann, A.; Korup, O.; Iroumé, A.; Francke, T.; Bronstert, A.

    2014-03-01

    Deforestation is a prominent anthropogenic cause of erosive overland flow and slope instability, boosting rates of soil erosion and concomitant sediment flux. Conventional methods of gauging or estimating post-logging sediment flux often focus on annual timescales but overlook potentially important process response on shorter intervals immediately following timber harvest. We resolve such dynamics with non-parametric quantile regression forests (QRF) based on high-frequency (3 min) discharge measurements and sediment concentration data sampled every 30-60 min in similar-sized (˜0.1 km2) forested Chilean catchments that were logged during either the rainy or the dry season. The method of QRF builds on the random forest algorithm, and combines quantile regression with repeated random sub-sampling of both cases and predictors. The algorithm belongs to the family of decision-tree classifiers, which allow quantifying relevant predictors in high-dimensional parameter space. We find that, where no logging occurred, ˜80% of the total sediment load was transported during extremely variable runoff events during only 5% of the monitoring period. In particular, dry-season logging dampened the relative role of these rare, extreme sediment-transport events by increasing load efficiency during more efficient moderate events. We show that QRFs outperform traditional sediment rating curves (SRCs) in terms of accurately simulating short-term dynamics of sediment flux, and conclude that QRF may reliably support forest management recommendations by providing robust simulations of post-logging response of water and sediment fluxes at high temporal resolution.

  3. Improved production log interpretation in horizontal wells using pulsed neutron logs

    SciTech Connect

    Brady, J.L.; Kohring, J.J.; North, R.J.

    1996-12-31

    Production log flow profiles provide a valuable tool to evaluate well and reservoir performance. Horizontal wellbores and their associated completion designs present several challenges to profile interpretation for conventional production logging sensors and techniques. A unique approach combining pulsed neutron capture (PNC) log data with conventional production logging measurements is providing improved flow profile answers in slotted liner, horizontal well completions on the North Slope of Alaska. Identifying and eliminating undesirable gas production is one of the chief goals of production logging on the North Slope. This process becomes difficult in horizontal wellbores as fluid segregation affects the area investigated by the various logging sensors and also the velocities of the individual phases. Typical slotted liner completions further complicate analysis as fluids are able to flow in the liner/openhole annulus. Analysis of PNC log data provides two good qualitative indicators of formation permeability. The first technique is derived from the difference of the formation sigma response before and after injecting a high-capture cross-section borax solution. The second technique uses the difference of the formation sigma response and the formation porosity measured while injecting the formation with crude or seawater. Further analysis of PNC log runs show that the two techniques closely correlate with production flow profiles under solution gas-oil ratio (GOR) conditions. These two techniques in combination with conventional production logging measurements of temperature, capacitance, pressure, and spinner improve flow profile results. PNC results can be combined with temperature and pressure data in the absence of valid spinner data to provide an approximate flow profile. These techniques have been used to successfully determine profiles in both cemented and slotted liner completions with GORs in excess of 15,000 scf/bbl.

  4. The application of PGNAA borehole logging for copper grade estimation at Chuquicamata mine.

    PubMed

    Charbucinski, J; Duran, O; Freraut, R; Heresi, N; Pineyro, I

    2004-05-01

    The field trials of a prompt gamma neutron activation (PGNAA) spectrometric logging method and instrumentation (SIROLOG) for copper grade estimation in production holes of a porphyry type copper ore mine, Chuquicamata in Chile, are described. Examples of data analysis, calibration procedures and copper grade profiles are provided. The field tests have proved the suitability of the PGNAA logging system for in situ quality control of copper ore. PMID:15082058

  5. Solar flare activity changes and global magnetic field disturbances

    NASA Astrophysics Data System (ADS)

    Bumba, V.; Hejna, L.

    1988-01-01

    Published observational data on solar-flare activity in the period 1965-1980 are analyzed statistically and related to changes in the magnetic active longitudes (MALs) identified and studied by Bumba and Hejna (1986). MALs are long strips of single-polarity fields which may persist for about 8-30 rotations and display internal structure. The data sets employed are briefly characterized, and the results are presented graphically. Flare maxima are found to correlate well with MAL disturbances, especially during the ascending phase of the solar cycle and with MALs of negative polarity. The possible implications of these findings for the interplanetary magnetic field and for theoretical models of flare generation are indicated.

  6. The X-ray log N-log S relation. [background radiation in extragalactic media

    NASA Technical Reports Server (NTRS)

    Boldt, Elihu

    1989-01-01

    Results from various surveys are reviewed as regards X-ray source counts at high galactic latitudes and the luminosity functions determined for extragalactic sources. Constraints on the associated log N-log S relation provided by the extragalactic X-ray background are emphasized in terms of its spatial fluctuations and spectrum as well as absolute flux level. The large number of sources required for this background suggests that there is not a sharp boundary in the redshift distribution of visible matter.

  7. Comparative in vivo study of precursors of PpIX (ALA and MAL) used topically in photodynamic therapy

    NASA Astrophysics Data System (ADS)

    Rego, Raquel F.; Inada, Natalia M.; Ferreira, Juliana; Araújo-Moreira, Fernando M.; Bagnato, Vanderlei S.

    2009-06-01

    The efficacy of Photodynamic Therapy (PDT) combined with aminolevulinic acid (ALA) or methyl aminolevulinate (MAL) in treatment of cancer has been studied for over ten years. However, there is no established dose for the topical use of these drugs in PDT. The purpose of this study was the comparison of induced PDT response of ALAsense (5-aminolevulinic acid - ALA) and Metvix (methyl aminolevulinate - MAL). Depth of necrosis induced by PDT was analyzed in normal liver of male Wistar rats, using different light doses and topical application of both PpIX precursors - ALA and MAL. PDT was performed with a diode laser at 630 nm with different doses of light (20, 50, 100 and 200 J/cm2), and intensity of 250 mW/cm2. Depth of necrosis analysis was used to calculate the threshold dose for each drug. The results showed that MAL-PDT presented a better response than ALA-PDT, mainly due to formulation differences. Moreover, the ability of the ALA PpIX production was more efficient.

  8. Measuring pad arrangement for a logging sonde

    SciTech Connect

    Vannier, D.; Tromelin, J.

    1989-08-29

    This patent describes a logging sonde for use in a borehole traversing an earth formation. The logging sonde comprising: an elongated sonde body; a plurality of measuring means for measuring a characteristic of the earth formation. Each of the measuring means comprising: a central element; a first measuring flap hingably connected to the central element; a second measuring flap hingable connected to the central element. The measuring flaps being disposed on either side of the central element, the first measuring flap staggered relative to the second measuring flap along the longitudinal direction of the sonde body; means operatively connected between the sonde body and the first and second measuring flaps for applying a resilient force to each of the measuring flaps, thereby tending to move the flaps away from the sonde body; and means connected between the sonde body and each of the measuring means for translocating the measuring means away from and back to the sonde body.

  9. Quantifying logging residue - before the fact

    SciTech Connect

    Bones, J.T.

    1982-06-01

    Tree biomass estimation, which is being integrated into the U.S. Forest Service Renewable Resources Evaluation Program, will give foresters the ability to estimate the amount of logging residues they might expect from harvested treetops and branches and residual rough, rotten, and small trees before the actual harvest. With planning, and increased demand for such timber products as pulpwood and fuelwood, product recovery could be increased by up to 43 percent in softwood stands and 99% in hardwoods. Recovery levels affect gross product receipts and site preparation costs. An example of product recovery and residue generation is presented for three harvesting options in Pennsylvania hardwood stands. Under the whole-tree harvesting option, 46% more product was recovered than in single product harvesting, and logging residue levels were reduced by 58%.

  10. INSPIRE and SPIRES Log File Analysis

    SciTech Connect

    Adams, Cole; /Wheaton Coll. /SLAC

    2012-08-31

    SPIRES, an aging high-energy physics publication data base, is in the process of being replaced by INSPIRE. In order to ease the transition from SPIRES to INSPIRE it is important to understand user behavior and the drivers for adoption. The goal of this project was to address some questions in regards to the presumed two-thirds of the users still using SPIRES. These questions are answered through analysis of the log files from both websites. A series of scripts were developed to collect and interpret the data contained in the log files. The common search patterns and usage comparisons are made between INSPIRE and SPIRES, and a method for detecting user frustration is presented. The analysis reveals a more even split than originally thought as well as the expected trend of user transition to INSPIRE.

  11. LOTUS template for calculating well logs

    SciTech Connect

    Mitchell, R.J. ); Taylor, S.J. )

    1993-09-01

    Calculating well logs is a time-consuming process. This template uses input parameters consisting of well name, location county, state, formation name, starting depth, repeat interval, resistivity of shale, and irreducible bulk volume water, which provides heading information for print outs. Required information from basic well logs are porosity, conductivity (optional), formation resistivity, resistivity of the formation water for the zone being calculated, resistivity of the mud filtrate, the porosity cutoff for pay in the zone being calculated, and the saltwater saturation cutoff for the pay zone. These parameters are used to calculate apparent water resistivity, saltwater saturation, bulk volume water, ratio of apparent water resistivity to input water resistivity, irreducible saltwater saturation, resistivity volume of shale, permeability, and a derived porosity value. A print out of the results is available through the lotus print function. Using this template allows maximum control of the input parameters and reduces hand calculation time.

  12. Using Web Logs in the Science Classroom

    ERIC Educational Resources Information Center

    Duplichan, Staycle C.

    2009-01-01

    As educators we must ask ourselves if we are meeting the needs of today's students. The science world is adapting to our ever-changing society; are the methodology and philosophy of our educational system keeping up? In this article, you'll learn why web logs (also called blogs) are an important Web 2.0 tool in your science classroom and how they…

  13. Quantitative Literacy: Working with Log Graphs

    NASA Astrophysics Data System (ADS)

    Shawl, S.

    2013-04-01

    The need for working with and understanding different types of graphs is a common occurrence in everyday life. Examples include anything having to do investments, being an educated juror in a case that involves evidence presented graphically, and understanding many aspect of our current political discourse. Within a science class graphs play a crucial role in presenting and interpreting data. In astronomy, where the range of graphed values is many orders of magnitude, log-axes must be used and understood. Experience shows that students do not understand how to read and interpret log-axes or how they differ from linear. Alters (1996), in a study of college students in an algebra-based physics class, found little understanding of log plotting. The purpose of this poster is to show the method and progression I have developed for use in my “ASTRO 101” class, with the goal being to help students better understand the H-R diagram, mass-luminosity relationship, and digital spectra.

  14. Chiral gravity, log gravity, and extremal CFT

    SciTech Connect

    Maloney, Alexander; Song Wei; Strominger, Andrew

    2010-03-15

    We show that the linearization of all exact solutions of classical chiral gravity around the AdS{sub 3} vacuum have positive energy. Nonchiral and negative-energy solutions of the linearized equations are infrared divergent at second order, and so are removed from the spectrum. In other words, chirality is confined and the equations of motion have linearization instabilities. We prove that the only stationary, axially symmetric solutions of chiral gravity are BTZ black holes, which have positive energy. It is further shown that classical log gravity--the theory with logarithmically relaxed boundary conditions--has finite asymptotic symmetry generators but is not chiral and hence may be dual at the quantum level to a logarithmic conformal field theories (CFT). Moreover we show that log gravity contains chiral gravity within it as a decoupled charge superselection sector. We formally evaluate the Euclidean sum over geometries of chiral gravity and show that it gives precisely the holomorphic extremal CFT partition function. The modular invariance and integrality of the expansion coefficients of this partition function are consistent with the existence of an exact quantum theory of chiral gravity. We argue that the problem of quantizing chiral gravity is the holographic dual of the problem of constructing an extremal CFT, while quantizing log gravity is dual to the problem of constructing a logarithmic extremal CFT.

  15. Log-transforming the matter power spectrum

    NASA Astrophysics Data System (ADS)

    Greiner, M.; Enßlin, T. A.

    2015-02-01

    We investigate whether non-linear effects on the large-scale power spectrum of dark matter, namely the increase in small-scale power and the smearing of baryon acoustic oscillations, can be decreased by a log-transformation or emulated by an exponential transformation of the linear spectrum. To that end we present a formalism to convert the power spectrum of a log-normal field to the power spectrum of the logarithmic Gaussian field and vice versa. All ingredients of our derivation can already be found in various publications in cosmology and other fields. We follow a more pedagogical approach providing a detailed derivation, application examples, and a discussion of implementation subtleties in one text. We use the formalism to show that the non-linear increase in small-scale power in the matter power spectrum is significantly smaller for the log-transformed spectrum which fits the linear spectrum (with less than 20% error) for redshifts down to 1 and k ≤ 1.0 h Mpc. For lower redshifts the fit to the linear spectrum is not as good, but the reduction of non-linear effects is still significant. Similarly, we show that applying the linear growth factor to the logarithmic density leads to an automatic increase in small-scale power for low redshifts fitting to third-order perturbation spectra and Cosmic Emulator spectra with an error of less than 20%. Smearing of baryon acoustic oscillations is at least three times weaker, but still present.

  16. Interactions Between Hillslope Processes and Channel Form in a Logged Coastal Redwood Forest

    NASA Astrophysics Data System (ADS)

    Lisle, T. E.; Reid, L. M.; Hilton, S.

    2009-12-01

    Impacts of land-use activities can appear far downstream of the activity sites, introducing potentials for downstream impact accumulation and for lengthy time-lags between activity and impact. Consequently, attribution of particular downstream changes to specific upstream activities is often difficult. We conducted a series of hydrologic and geomorphic studies to evaluate pathways of influence between changes occurring on hillslopes and downstream channel responses at the Caspar Creek Experimental Watersheds in northwest California. About 39% of the second-growth redwood forest in the 473-ha North Fork Caspar Creek watershed was clearcut between 1989 and 1991. Stream gauges at the mouths of five logged subwatersheds showed increased average peakflow, runoff, and suspended sediment yield relative to three control watersheds. Modeling on the basis of rainfall interception measurements suggests that about 2/3 of the change in peakflow magnitudes results from altered interception after logging and 1/3 from reduced transpiration. Field surveys of erosion process distribution—including landslides, surface erosion, bank erosion, and gully erosion—suggest that in-channel erosion processes provided the dominant influence on sediment increases in the three years following logging. Changes in sediment load are most strongly correlated with runoff changes, but sediment increases at the mouth of the watershed are lower than predicted from sub-watershed outputs, suggesting deposition has occurred along the mainstem. Comparison of channel characteristics in logged and control watersheds indicates that networks expanded headward in the logged watersheds to a point that stream-power indices reflecting the altered hydrology are equivalent to those at channel heads before logging. In addition, channels are wider and deeper in reaches draining logged watersheds. Cross sections are resurveyed and woody debris tagged and remapped at approximately 2-year intervals along the North

  17. MAL Overexpression Leads to Disturbed Expression of Genes That Influence Cytoskeletal Organization and Differentiation of Schwann Cells

    PubMed Central

    Schmid, Daniela; Zeis, Thomas; Sobrio, Monia

    2014-01-01

    In the developing peripheral nervous system, a coordinated reciprocal signaling between Schwann cells and axons is crucial for accurate myelination. The myelin and lymphocyte protein MAL is a component of lipid rafts that is important for targeting proteins and lipids to distinct domains. MAL overexpression impedes peripheral myelinogenesis, which is evident by a delayed onset of myelination and reduced expression of the myelin protein zero (Mpz/P0) and the low-affinity neurotrophin receptor p75NTR. This study shows that MAL overexpression leads to a significant reduction of Mpz and p75NTR expression in primary mouse Schwann cell cultures, which was already evident before differentiation, implicating an effect of MAL in early Schwann cell development. Their transcription was robustly reduced, despite normal expression of essential transcription factors and receptors. Further, the cAMP response element-binding protein (CREB) and phosphoinositide 3-kinase signaling pathways important for Schwann cell differentiation were correctly induced, highlighting that other so far unknown rate limiting factors do exist. We identified novel genes expressed by Schwann cells in a MAL-dependent manner in vivo and in vitro. A number of those, including S100a4, RhoU and Krt23, are implicated in cytoskeletal organization and plasma membrane dynamics. We showed that S100a4 is predominantly expressed by nonmyelinating Schwann cells, whereas RhoU was localized within myelin membranes, and Krt23 was detected in nonmyelinating as well as in myelinating Schwann cells. Their differential expression during early peripheral nerve development further underlines their possible role in influencing Schwann cell differentiation and myelination. PMID:25290060

  18. SmartMal: A Service-Oriented Behavioral Malware Detection Framework for Mobile Devices

    PubMed Central

    Wu, Zhizhong; Li, Xi; Zhou, Xuehai; Wang, Aili; Hung, Patrick C. K.

    2014-01-01

    This paper presents SmartMal—a novel service-oriented behavioral malware detection framework for vehicular and mobile devices. The highlight of SmartMal is to introduce service-oriented architecture (SOA) concepts and behavior analysis into the malware detection paradigms. The proposed framework relies on client-server architecture, the client continuously extracts various features and transfers them to the server, and the server's main task is to detect anomalies using state-of-art detection algorithms. Multiple distributed servers simultaneously analyze the feature vector using various detectors and information fusion is used to concatenate the results of detectors. We also propose a cycle-based statistical approach for mobile device anomaly detection. We accomplish this by analyzing the users' regular usage patterns. Empirical results suggest that the proposed framework and novel anomaly detection algorithm are highly effective in detecting malware on Android devices. PMID:25165729

  19. Infant Feeding Practices, Dietary Adequacy, and Micronutrient Status Measures in the MAL-ED Study

    PubMed Central

    Caulfield, Laura E.; Bose, Anuradha; Chandyo, Ram Krishna; Nesamvuni, Cebisa; de Moraes, Milena Lima; Turab, Ali; Patil, Crystal; Mahfuz, Mustafa; Ambikapathi, Ramya; Ahmed, Tahmeed

    2014-01-01

    The overall goal of The Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) cohort study is to evaluate the roles of repeated enteric infection and poor dietary intakes on the development of malnutrition, poor cognitive development, and diminished immune response. The use of 8 distinct sites for data collection from Latin America, sub-Saharan Africa, and South Asia allow for an examination of these relationships across different environmental contexts. Key to testing study hypotheses is the collection of appropriate data to characterize the dietary intakes and nutritional status of study children from birth through 24 months of age. The focus of the current article is on the collection of data to describe the nature and adequacy of infant feeding, energy and nutrient intakes, and the chosen indicators to capture micronutrient status in children over time. PMID:25305294

  20. [Metabolism and elimination of ethosuximide in neonates whose mothers had petit mal].

    PubMed

    Tejerizo López, L C; de Santiago Obeso, J; Henríquez Esquiroz, J M; Pérez González, M C; Jorge Mendoza, J M

    1987-11-01

    In thirteen newborn infants of mothers affected with "petit mal" and treated with ethosuximide, submitted to artificial feeding with powdered milk, it was found that transplacental elimination of the drug occurred. Authors recorded daily serum concentration of ethosuximide and found that average life before it was totally eliminated was 80.62 +/- 7.24 hours. At the moment of birth serum concentration of mothers, and their newborn infants are similar due to transplacental by-pass. Through a lineal regression coefficient they find a relation between serum concentration in newborn infants and time passed from the moment of birth. This coefficient was negative and thus signified facility of the newborn to eliminate the drug. This result allows us to treat the mother adequately during anti-natal period with adequate dose to avoid subsequent epileptic attacks without producing toxicity in the newborn child. PMID:3125772

  1. On the hydrophobicity of peptides: Comparing empirical predictions of peptide log P values.

    PubMed

    Thompson, Sarah J; Hattotuwagama, Channa K; Holliday, John D; Flower, Darren R

    2006-01-01

    Peptides are of great therapeutic potential as vaccines and drugs. Knowledge of physicochemical descriptors, including the partition coefficient logP, is useful for the development of predictive Quantitative Structure-Activity Relationships (QSARs). We have investigated the accuracy of available programs for the prediction of logP values for peptides with known experimental values obtained from the literature. Eight prediction programs were tested, of which seven programs were fragment-based methods: XLogP, LogKow, PLogP, ACDLogP, AlogP, Interactive Analysis's LogP and MlogP; and one program used a whole molecule approach: QikProp. The predictive accuracy of the programs was assessed using r(2) values, with ALogP being the most effective (r( 2) = 0.822) and MLogP the least (r(2) = 0.090). We also examined three distinct types of peptide structure: blocked, unblocked, and cyclic. For each study (all peptides, blocked, unblocked and cyclic peptides) the performance of programs rated from best to worse is as follows: all peptides - ALogP, QikProp, PLogP, XLogP, IALogP, LogKow, ACDLogP, and MlogP; blocked peptides - PLogP, XLogP, ACDLogP, IALogP, LogKow, QikProp, ALogP, and MLogP; unblocked peptides - QikProp, IALogP, ALogP, ACDLogP, MLogP, XLogP, LogKow and PLogP; cyclic peptides - LogKow, ALogP, XLogP, MLogP, QikProp, ACDLogP, IALogP. In summary, all programs gave better predictions for blocked peptides, while, in general, logP values for cyclic peptides were under-predicted and those of unblocked peptides were over-predicted. PMID:17597897

  2. Log-periodic route to fractal functions.

    PubMed

    Gluzman, S; Sornette, D

    2002-03-01

    Log-periodic oscillations have been found to decorate the usual power-law behavior found to describe the approach to a critical point, when the continuous scale-invariance symmetry is partially broken into a discrete-scale invariance symmetry. For Ising or Potts spins with ferromagnetic interactions on hierarchical systems, the relative magnitude of the log-periodic corrections are usually very small, of order 10(-5). In growth processes [diffusion limited aggregation (DLA)], rupture, earthquake, and financial crashes, log-periodic oscillations with amplitudes of the order of 10% have been reported. We suggest a "technical" explanation for this 4 order-of-magnitude difference based on the property of the "regular function" g(x) embodying the effect of the microscopic degrees of freedom summed over in a renormalization group (RG) approach F(x)=g(x)+mu(-1)F(gamma x) of an observable F as a function of a control parameter x. For systems for which the RG equation has not been derived, the previous equation can be understood as a Jackson q integral, which is the natural tool for describing discrete-scale invariance. We classify the "Weierstrass-type" solutions of the RG into two classes characterized by the amplitudes A(n) of the power-law series expansion. These two classes are separated by a novel "critical" point. Growth processes (DLA), rupture, earthquake, and financial crashes thus seem to be characterized by oscillatory or bounded regular microscopic functions that lead to a slow power-law decay of A(n), giving strong log-periodic amplitudes. If in addition, the phases of A(n) are ergodic and mixing, the observable presents self-affine nondifferentiable properties. In contrast, the regular function of statistical physics models with "ferromagnetic"-type interactions at equilibrium involves unbound logarithms of polynomials of the control variable that lead to a fast exponential decay of A(n) giving weak log-periodic amplitudes and smoothed observables. PMID

  3. Bhaktapur, Nepal: the MAL-ED birth cohort study in Nepal.

    PubMed

    Shrestha, Prakash Sunder; Shrestha, Sanjaya Kumar; Bodhidatta, Ladaporn; Strand, Tor; Shrestha, Binob; Shrestha, Rita; Chandyo, Ram Krishna; Ulak, Manjeswori; Mason, Carl J

    2014-11-01

    The Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) cohort study site in Nepal is located in the Bhaktapur municipality, 15 km east of Kathmandu, the capital city of Nepal. Bhaktapur, an ancient city famous for its traditional temples and buildings, is included on UNESCO's World Heritage List and is a major tourist attraction in Nepal. Nepal is a land-locked country located in South Asia between China and India with an area of 147 181 km(2), ranging from sea-level plains to Mount Everest, the world's highest peak. The total population as of the 2011 census was 26.6 million, with an average annual population growth rate of 1.4. Nepal is one of the world's least developed countries and is ranked 157 of 186 in the 2013 Human Development Report; one-third of the Nepali population lives below the poverty line. The current under-5 mortality rate is 54 per 1000 live births, the infant mortality rate is 46 per 1000 live births, and the neonatal mortality rate is 33 per 1000 live births. Vaccine coverage for all Expanded Program on Immunization vaccines is >80%. Among children, the most common diseases contributing to significant morbidity and mortality are acute respiratory infection and dehydration from severe diarrhea. In this article, we report on the geographic, demographic, and socioeconomic features of the Bhaktapur MAL-ED site and describe the data that informed our cohort recruitment strategy. PMID:25305301

  4. The elastic, electronic and magnetism structure of the MAl and M3Al (M=Fe and Ni) alloy with and without hydrogen atoms

    NASA Astrophysics Data System (ADS)

    Mubarak, A. A.

    2016-03-01

    The energetic stability, electronic and magnetism of the MAl, M3Al alloy (M=Fe, Ni) and variant surfaces of MAl (001) with and without hydrogen atoms are investigated by utilizing DFT and GGA as the exchange-correlation potential. All presented alloys with and without the H atom absorption is found elastically and thermodynamically stable. The calculated absorption energy shows that H is more energetically stable in the bridge and octahedral site in MAl and M3Al alloys, respectively. Hydrogen atoms absorption is expanded and brittle the studied host alloys. The ability of absorption of H atom at more than one site in the MAl alloy is found energetically and thermodynamically stable. The H adsorption on the variant surfaces of MAl (001) is predicted too. Fourfold and top sites are found more energetically stable to adsorbed the H atom on the above surface layer of H/MAl-M and H/MAl-Al, respectively. The obvious changes are observed in the interlayer spacing for studied surfaces which yields to decrease the LDOS and magnetic moments of the surface and subsurface layers.

  5. Geophysical Logs of Selected Test Wells at the Diaz Chemical Superfund Site in Holley, New York

    USGS Publications Warehouse

    Eckhardt, David A.V.; Anderson, J. Alton

    2007-01-01

    In June and July 2006, geophysical logs were collected and analyzed along with rock-core samples to define the bedrock stratigraphy and flow zones penetrated by four test wells at the Diaz Chemical Superfund site at Holley in eastern Orleans County, New York. The work was completed as a preliminary part of the investigation of contamination by organic compounds in the shale, mudstone, and sandstone bedrock. The geophysical logs included natural-gamma, caliper, borehole image, fluid properties, and flowmeter data. The orientation of fractures in the boreholes was inferred from the log data and summarized in stereo and tadpole plots; the transmissivity and hydraulic head was also determined for fracture zones that were observed to be hydraulically active through the flowmeter logs. The data are intended in part for use in the remediation of the site.

  6. Generalized localization for the double trigonometric Fourier series and the Walsh-Fourier series of functions in L\\log^+L\\log^+\\log^+L

    NASA Astrophysics Data System (ADS)

    Bloshanskaya, S. K.; Bloshanskii, I. L.; Y Roslova, T.

    1998-06-01

    For an arbitrary open set \\Omega\\subset I^2= \\lbrack 0,1)^2 and an arbitrary function f\\in L\\log^+L\\log^+\\log^+L(I^2) such that f=0 on \\Omega the double Fourier series of f with respect to the trigonometric system \\Psi=\\mathscr E and the Walsh-Paley system \\Psi=W is shown to converge to zero (over rectangles) almost everywhere on \\Omega. Thus, it is proved that generalized localization almost everywhere holds on arbitrary open subsets of the square I^2 for the double trigonometric Fourier series and the Walsh-Fourier series of functions in the class L\\log^+L\\log^+\\log^+L (in the case of summation over rectangles). It is also established that such localization breaks down on arbitrary sets that are not dense in I^2, in the classes \\Phi_\\Psi(L)(I^2) for the orthonormal system \\Psi=\\mathscr E and an arbitrary function such that \\Phi_{\\mathscr E}(u)=o(u\\log^+\\log^+u) as u\\to\\infty or for \\Phi_W(u)=u(\\log^+\\log^+u)^{1-\\varepsilon}, 0<\\varepsilon<1.

  7. Logging system adds value to field rejuvenation efforts

    SciTech Connect

    Peters, D.; Bartenhagen, K.; Santolamazza, A.

    1997-11-01

    As with any rejuvenation scheme, the first step is always identification and evaluation of potential producible reserves. But economic and physical factors made evaluation using traditional logging techniques problematic. The constraints that inhibited earlier logging tools have been addressed by a new, compact integrated system called Platform Express (PEX). Oil companies operating in two of the most mature producing regions of the US, the Hugoton-Panhandle Field and the Southwest Nena Lucia Field in West Texas, discuss the physical and economic advantages they are reaping using PEX technologies. Hugoton-Panhandle Field, discovered around 1920, sprawls across parts of three south-central states and has been one of the world`s largest gas producers. Despite continuing pressure declines in this aging gas giant, the entire region has undergone restoration in the last few years. In its Kansas portions, a modest oil production has almost doubled since 1990 and a steep gas decline has been completely turned around. These production gains have come from an active program of recompletions, the deepening of old holes and new drilling. The story in the southwest Nena Lucia Field is much the same. Operator Oryx Energy has been active in the field, located west of Abilene, Texas, since its discovery in the 1950s. The goal with this field is to use advanced technologies to reverse the production declines that began years ago. Such a reversal began in mid-1996 and has been sustained thus far.

  8. Nuclear Tools For Oilfield Logging-While-Drilling Applications

    NASA Astrophysics Data System (ADS)

    Reijonen, Jani

    2011-06-01

    Schlumberger is an international oilfield service company with nearly 80,000 employees of 140 nationalities, operating globally in 80 countries. As a market leader in oilfield services, Schlumberger has developed a suite of technologies to assess the downhole environment, including, among others, electromagnetic, seismic, chemical, and nuclear measurements. In the past 10 years there has been a radical shift in the oilfield service industry from traditional wireline measurements to logging-while-drilling (LWD) analysis. For LWD measurements, the analysis is performed and the instruments are operated while the borehole is being drilled. The high temperature, high shock, and extreme vibration environment of LWD imposes stringent requirements for the devices used in these applications. This has a significant impact on the design of the components and subcomponents of a downhole tool. Another significant change in the past few years for nuclear-based oilwell logging tools is the desire to replace the sealed radioisotope sources with active, electronic ones. These active radiation sources provide great benefits compared to the isotopic sources, ranging from handling and safety to nonproliferation and well contamination issues. The challenge is to develop electronic generators that have a high degree of reliability for the entire lifetime of a downhole tool. LWD tool testing and operations are highlighted with particular emphasis on electronic radiation sources and nuclear detectors for the downhole environment.

  9. 4. Exterior, detail south elevation, showing jointing of logs on ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Exterior, detail south elevation, showing jointing of logs on later extension. Sept. 12, 1940. Mixon. - Upper Swedish Log Cabin, Darby Creek vicinity, Clifton Heights (Upper Darby Township), Darby, Delaware County, PA

  10. 4. WEST SIDE ELEVATION SHOWING WEATHERBOARD LOG COVERING, DOOR CUT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. WEST SIDE ELEVATION SHOWING WEATHERBOARD LOG COVERING, DOOR CUT INTO WEST WALL TO ENTER DOG TROT, AND UPROOTED TREE WHERE LATER SECOND PEN WAS LOCATED (4 x 5 negative) - Thomas Jefferson Walling Log Cabin, Henderson, Rusk County, TX

  11. 6. SOUTHWEST CORNER DETAIL (FRONT AND LEFT SIDE) SHOWING LOG ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. SOUTHWEST CORNER DETAIL (FRONT AND LEFT SIDE) SHOWING LOG JOINERY AND WEATHERBOARDING (copy negative, original 35 mm negative in field records) - Thomas Jefferson Walling Log Cabin, Henderson, Rusk County, TX

  12. 7. NORTHEAST CORNER DETAIL SHOWING LOG JOINERY. AT RIGHT IS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. NORTHEAST CORNER DETAIL SHOWING LOG JOINERY. AT RIGHT IS REAR SHED ROOM ADDITION (copy negative, original 35 mm negative in field records) - Thomas Jefferson Walling Log Cabin, Henderson, Rusk County, TX

  13. 2. VIEW OF BLOCK AND TACKLE FOR MOVING CEDAR LOGS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. VIEW OF BLOCK AND TACKLE FOR MOVING CEDAR LOGS FROM POND TO JACK LADDER--AN ENDLESS CHAIN CONVEYOR THAT MOVES LOGS INTO MILL - Lester Shingle Mill, 1602 North Eighteenth Street, Sweet Home, Linn County, OR

  14. 8. Double crib barn, south corner, log section, loft area, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Double crib barn, south corner, log section, loft area, detail of log construction - Wilkins Farm, Barn, South side of Dove Hollow Road, 6000 feet east of State Route 259, Lost City, Hardy County, WV

  15. 35. SOUTHWEST CORNER OF EAST CHIMNEY BASE SHOWING CONTINUOUS LOG ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    35. SOUTHWEST CORNER OF EAST CHIMNEY BASE SHOWING CONTINUOUS LOG FOUNDATION OVER VAULT AND THE WEST CRIBBING LOG WITH STONE FILL ON THE EAST. - Penacook House, Daniel Webster Highway (U.S. Route 3), Boscawen, Merrimack County, NH

  16. 5. Log draft horse barn. Detail of west side showing ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Log draft horse barn. Detail of west side showing Dutch door and square notching at wall corner. View to east. - William & Lucina Bowe Ranch, Log Draft Horse Barn, 290 feet southwest of House, Melrose, Silver Bow County, MT

  17. 6. SIDE ELEVATION, DETAIL SHOWING ORIGINAL LOG CONSTRUCTION, CLAPBOARD ADDITION ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. SIDE ELEVATION, DETAIL SHOWING ORIGINAL LOG CONSTRUCTION, CLAPBOARD ADDITION AND CHIMNEY STACK - Shinn-Curtis Log Cabin, 23 Washington Street (moved from Rancocas Boulevard), Mount Holly, Burlington County, NJ

  18. 8. William E. Barrett, Photographer, August 1975. LOG DOCK AND ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. William E. Barrett, Photographer, August 1975. LOG DOCK AND PARTIALLY DEMOLISHED JACKSLIP USED FOR HAULING LOGS UP TO SAWMILL. - Meadow River Lumber Company, Highway 60, Rainelle, Greenbrier County, WV

  19. 3. MAIN ELEVATION, DETAIL SHOWING HEWN LOGS WITH HALFDOVETAIL JOINTS; ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. MAIN ELEVATION, DETAIL SHOWING HEWN LOGS WITH HALF-DOVETAIL JOINTS; LATHE AND PLASTER ADDITION; AND CLAPBOARD SIDING - Shinn-Curtis Log Cabin, 23 Washington Street (moved from Rancocas Boulevard), Mount Holly, Burlington County, NJ

  20. Evaluation of an anti-p185HER2 (scFv-CH2-CH3)2 fragment following radioiodination using two different residualizing labels: SGMIB and IB-Mal-D-GEEEK

    PubMed Central

    Vaidyanathan, Ganesan; Jestin, Emmanuelle; Olafsen, Tove; Wu, Anna M.; Zalutsky, Michael R.

    2009-01-01

    Introduction A 105 kDa double mutant single-chain Fv-Fc fragment (scFv-Fc DM) derived from the anti-p185HER2 hu4D5v8 antibody (trastuzumab; Herceptin™) has been described recently. The goal of this study was to investigate whether improved tumor targeting could be achieved with this fragment through the use of residualizing radioiodination methods. Methods The scFv-Fc DM fragment was radioiodinated using N-succinimidyl 4-guanidinomethyl 3-[131I]iodobenzoate ([131I]SGMIB) and N-(3-[131I]iodobenzoyl)-Lys5-N- maleimido-Gly 1-GEEEK ([131I]IB-Mal-D-GEEEK), two residualizing radioiodination agents that have been used successfully with intact antibodies. Paired-label internalization assays of the labeled fragments were performed in vitro using MCF7 human breast cancer cells transfected to express HER2 (MCF7-HER2); comparisons were made to scFv-Fc DM directly radioiodinated using Iodogen. The tissue distribution of the scFv-Fc DM labeled with [125I]IB-Mal-D-GEEEK and [131I]SGMIB was compared in athymic mice bearing MCF7-HER2 xenografts. Results The scFv-Fc DM fragment was labeled with [131I]SGMIB and [131I]IB-Mal-D-GEEEK in conjugation yields of 53% and 25%, respectively, with preservation of immunoreactivity for HER2. Internalization assays indicated that labeling via SGMIB resulted in a 1.6- to 3.5-fold higher (p < 0.05) retention of radioactivity, compared to that from the directly labeled fragment, in HER2-expressing cells during a 24 h observation period. Likewise, the amount of radioactivity retained in cells from the IB-Mal-D-GEEEK-labeled fragment was 1.4- to 3.3-fold higher (p < 0.05). Tumor uptake of radioiodine activity in athymic mice bearing MCF7-HER2 xenografts in vivo was significantly higher for the [125I]IB-Mal-D-GEEEK-labeled scFv-Fc DM fragment compared with that of the [131I]SGMIB-labeled fragment, particularly at later time points. The uptake of 125I was 3-fold (3.6 ± 1.1%ID/g versus 1.2 ± 0.4%ID/g) and 4-fold (3.1 ± 1.7%ID/g versus 0.8 ± 0.4%ID

  1. Apparatus for focused electrode induced polarization logging

    SciTech Connect

    Vinegar, H.J.; Waxman, M.H.

    1986-04-15

    An induced polarization logging tool is described for measuring parameters of a formation surrounding a borehole. The logging tool consists of: a non-conductive logging sonde; a plurality of electrodes disposed on the sonde, the electrodes including at least a survey current electrode and guard electrodes disposed on opposite sides of the survey current electrode, a non-polarizing voltage measuring electrode, a non-polarizing voltage reference electrode and a current return electrode, both the voltage reference and current return electrodes being located a greater distance from the survey current electrode than the guard electrodes; means connected to the survey current electrode and the guard electrodes for generating a signal representative of the potential difference in the formation between the survey current electrode and the guard electrodes; first control means directly coupled to the survey current electrode, the first control means controlling the current flow to the survey current electrode in response to the potential difference signal; a second control means directly coupled to the guard electrodes to control the current flow to the guard electrodes in response to the potential difference signal; a source of alternating current located at the surface, one end of the source being coupled to the two control means and the other to the current return electrode, the source supplying alternating current at various discrete frequencies between substantially 0.01 and 100 Hz; measurement means directly coupled to the voltage measurement and survey current electrodes to measure the amplitude and phase of the voltage induced in the formation and the amplitude and phase of the current flow to the survey electrode; and transmission means for transmitting the measurements to the surface.

  2. Well log evaluation of natural gas hydrates

    SciTech Connect

    Collett, T.S.

    1992-10-01

    Gas hydrates are crystalline substances composed of water and gas, in which a solid-water-lattice accommodates gas molecules in a cage-like structure. Gas hydrates are globally widespread in permafrost regions and beneath the sea in sediment of outer continental margins. While methane, propane, and other gases can be included in the clathrate structure, methane hydrates appear to be the most common in nature. The amount of methane sequestered in gas hydrates is probably enormous, but estimates are speculative and range over three orders of magnitude from about 100,000 to 270,000,000 trillion cubic feet. The amount of gas in the hydrate reservoirs of the world greedy exceeds the volume of known conventional gas reserves. Gas hydrates also represent a significant drilling and production hazard. A fundamental question linking gas hydrate resource and hazard issues is: What is the volume of gas hydrates and included gas within a given gas hydrate occurrence Most published gas hydrate resource estimates have, of necessity, been made by broad extrapolation of only general knowledge of local geologic conditions. Gas volumes that may be attributed to gas hydrates are dependent on a number of reservoir parameters, including the areal extent ofthe gas-hydrate occurrence, reservoir thickness, hydrate number, reservoir porosity, and the degree of gas-hydrate saturation. Two of the most difficult reservoir parameters to determine are porosity and degreeof gas hydrate saturation. Well logs often serve as a source of porosity and hydrocarbon saturation data; however, well-log calculations within gas-hydrate-bearing intervals are subject to error. The primary reason for this difficulty is the lack of quantitative laboratory and field studies. The primary purpose of this paper is to review the response of well logs to the presence of gas hydrates.

  3. Well log evaluation of natural gas hydrates

    SciTech Connect

    Collett, T.S.

    1992-10-01

    Gas hydrates are crystalline substances composed of water and gas, in which a solid-water-lattice accommodates gas molecules in a cage-like structure. Gas hydrates are globally widespread in permafrost regions and beneath the sea in sediment of outer continental margins. While methane, propane, and other gases can be included in the clathrate structure, methane hydrates appear to be the most common in nature. The amount of methane sequestered in gas hydrates is probably enormous, but estimates are speculative and range over three orders of magnitude from about 100,000 to 270,000,000 trillion cubic feet. The amount of gas in the hydrate reservoirs of the world greedy exceeds the volume of known conventional gas reserves. Gas hydrates also represent a significant drilling and production hazard. A fundamental question linking gas hydrate resource and hazard issues is: What is the volume of gas hydrates and included gas within a given gas hydrate occurrence? Most published gas hydrate resource estimates have, of necessity, been made by broad extrapolation of only general knowledge of local geologic conditions. Gas volumes that may be attributed to gas hydrates are dependent on a number of reservoir parameters, including the areal extent ofthe gas-hydrate occurrence, reservoir thickness, hydrate number, reservoir porosity, and the degree of gas-hydrate saturation. Two of the most difficult reservoir parameters to determine are porosity and degreeof gas hydrate saturation. Well logs often serve as a source of porosity and hydrocarbon saturation data; however, well-log calculations within gas-hydrate-bearing intervals are subject to error. The primary reason for this difficulty is the lack of quantitative laboratory and field studies. The primary purpose of this paper is to review the response of well logs to the presence of gas hydrates.

  4. Characterisation and antimicrobial activity of the volatile components of the flowers of Magydaris tomentosa (Desf.) DC. collected in Sicily and Algeria.

    PubMed

    Khaoukha, Guesmia; Ben Jemia, Mariem; Amira, Smain; Laouer, Hocine; Bruno, Maurizio; Scandolera, Elia; Senatore, Felice

    2014-01-01

    The essential oils of the flowers of Magydaris tomentosa (Desf.) DC. (Apiaceae) collected in Sicily (MSi) and Algeria (MAl), respectively, were obtained by hydrodistillation, and their compositions were analysed. The analyses allowed the identification and quantification of 23 components in MSi and 60 compounds in MAl, respectively, showing a very different profile in the composition of the two populations. The main components of MSi were cembrene (28.2%), α-springene (17.5%) and β-springene (14.8%), also present in MAl but in lesser amount (0.4%, 1.8% and 0.9%, respectively), whereas the principal constituents of MAl were (E)-nerolidol (35.4%), α-costol (13.3%) and β-costol (6.8%). Both MSi and MAl exhibited a significant antibacterial activity against Staphylococcus epidermidis (minimum inhibitory concentration = 25 and 12.5 μg/mL, respectively). The chemotaxonomy markers of the species were identified. PMID:24871127

  5. Outcrop gamma-ray logging applied to subsurface petroleum geology

    SciTech Connect

    Slatt, R.M.; Borer, J.M.; Horn, B.W.

    1995-10-01

    Developing a gamma-ray log profile of an outcrop with a hand-held scintillometer has many applications to subsurface petroleum geology. The outcrop gamma-ray log provides a readily understandable bridge between what is observed in outcrop and what is to be interpreted on well logs and seismic records. Several examples are presented in this paper that demonstrate major applications. An outcrop from the Cretaceous Mesaverde Group in Colorado provides an excellent example of the use of outcrop gamma-ray logs to better visualize spatial variability of depositional settings for improved well log correlations. Out crops from the Cretaceous Almond Formation, Niobrara Formation, and Graneros Shale in Colorado serve as examples of outcrop gamma-ray logging used to correlate outcrops with their subsurface equivalents for improved lithologic and stratigraphic interpretation of well logs. Outcrops of the Cretaceous Sharon Springs Member of the Pierre Shale in Colorado and the Eocene Green River Formation in Wyoming provide examples of the application of outcrop-gamma ray logging to identify and characterize organic-rich shales in outcrops and on well logs. Outcrops of the Pennsylvanian Jackfork Formation in Arkansas demonstrate the use of outcrop logging to yield improved interpretation of reservoir quality on well logs and for one- and two-dimensional seismic modeling. An outcrop of Precambrian and Cambro-Ordovician rocks from Algeria provides an example of outcrop logging to recognize unconformities and other major surfaces on well logs. An outcrop of the Niobrara Formation in Colorado is used as an example for improved understanding of horizontal gamma-ray log response. The example logs presented are all drived with a hand-held scintillometer. This technique is simple, quick, and relatively inexpensive, so is recommended for any outcrop work that is intended to be applied t;o subsurface well logs or seismic interpretation.

  6. Calibration Tests of a German Log Rodmeter

    NASA Technical Reports Server (NTRS)

    Mottard, Elmo J.; Stillman, Everette R.

    1949-01-01

    A German log rodmeter of the pitot static type was calibrated in Langley tank no. 1 at speeds up to 34 knots and angles of yaw from 0 deg to plus or minus 10 3/4 degrees. The dynamic head approximated the theoretical head at 0 degrees yaw but decreased as the yaw was increased. The static head was negative and in general became more negative with increasing speed and yaw. Cavitation occurred at speeds above 31 knots at 0 deg yaw and 21 knots at 10 3/4 deg yaw.

  7. Identifying related journals through log analysis

    PubMed Central

    Lu, Zhiyong; Xie, Natalie; Wilbur, W. John

    2009-01-01

    Motivation: With the explosion of biomedical literature and the evolution of online and open access, scientists are reading more articles from a wider variety of journals. Thus, the list of core journals relevant to their research may be less obvious and may often change over time. To help researchers quickly identify appropriate journals to read and publish in, we developed a web application for finding related journals based on the analysis of PubMed log data. Availability: http://www.ncbi.nlm.nih.gov/IRET/Journals Contact: luzh@ncbi.nlm.nih.gov Supplementary information: Supplementary data are available at Bioinformatics online. PMID:19734155

  8. VAFLE: visual analytics of firewall log events

    NASA Astrophysics Data System (ADS)

    Ghoniem, Mohammad; Shurkhovetskyy, Georgiy; Bahey, Ahmed; Otjacques, Benoît.

    2013-12-01

    In this work, we present VAFLE, an interactive network security visualization prototype for the analysis of firewall log events. Keeping it simple yet effective for analysts, we provide multiple coordinated interactive visualizations augmented with clustering capabilities customized to support anomaly detection and cyber situation awareness. We evaluate the usefulness of the prototype in a use case with network traffic datasets from previous VAST Challenges, illustrating its effectiveness at promoting fast and well-informed decisions. We explain how a security analyst may spot suspicious traffic using VAFLE. We further assess its usefulness through a qualitative evaluation involving network security experts, whose feedback is reported and discussed.

  9. Shear wave logging using guided waves

    SciTech Connect

    Winbow, G.A.; Chen, S.T.; Rice, J.A.

    1988-09-27

    This patent describes a method for acoustically logging an earth formation surrounding a borehole which contains a liquid where the approximate shear wave velocity v of the formation is known. The method consists of: vibrating a dipole source in the liquid to generate in the liquid a guided wave the frequencies of which include a critical frequency f given by zeta = ..nu..12a where a is the borehole radius, so that the fastest component of the guided wave has velocity substantially equal to ..nu..; and detecting the arrival of the fastest component of the guided wave at least one location in the liquid spaced longitudinally along the borehole from the dipole source.

  10. K - log P is that all?

    NASA Astrophysics Data System (ADS)

    Lub, J.

    2016-05-01

    We investigate the derivation of the K - log P relation for RR Lyrae stars based upon the simplest possible theoretical pulsation equation. Making use of recent theoretical advances due to Marconi et al. (2015) this leads to a direct determination of MV for individual stars, but at the same time we re- discover a simple method using the reddening free and metallicity independent combination W(B,V) = V -3.06(B-V) to do the same. We discuss the relation between the two approaches and compare with other determinations in the liter- ature. A consistent distance of the LMC is derived directly from measurements of its RR Lyrae stars.

  11. An electronic encounter log's failure to scale.

    PubMed

    Sumner, Walton; Asaro, Phil; Asaro, Phillip

    2008-01-01

    We have developed a series of Electronic Student Encounter Log (ESEL) programs intended to introduce medical students to promising medical informatics concepts. We attempted to expand ESELs scope from ambulatory settings to all hospital venues and to track progress toward educational goals. Students were confused and frustrated by a previously fast interface and delayed feedback. Numerous scaling problems emerged. Our attempt to address these problems in an extensive revision, developed for the latest affordable hardware and operating system, failed due to new data-corrupting crashes. Risks of scaling up and other familiar software development lessons are reinforced. PMID:18998815

  12. Log amplifier with pole-zero compensation

    DOEpatents

    Brookshier, W.

    1985-02-08

    A logarithmic amplifier circuit provides pole-zero compensation for improved stability and response time over 6-8 decades of input signal frequency. The amplifer circuit includes a first operational amplifier with a first feedback loop which includes a second, inverting operational amplifier in a second feedstock loop. The compensated output signal is provided by the second operational amplifier with the log elements, i.e., resistors, and the compensating capacitors in each of the feedback loops having equal values so that each break point is offset by a compensating break point or zero.

  13. Log amplifier with pole-zero compensation

    DOEpatents

    Brookshier, William

    1987-01-01

    A logarithmic amplifier circuit provides pole-zero compensation for improved stability and response time over 6-8 decades of input signal frequency. The amplifier circuit includes a first operational amplifier with a first feedback loop which includes a second, inverting operational amplifier in a second feedback loop. The compensated output signal is provided by the second operational amplifier with the log elements, i.e., resistors, and the compensating capacitors in each of the feedback loops having equal values so that each break point or pole is offset by a compensating break point or zero.

  14. Nonlinear filters with log-homotopy

    NASA Astrophysics Data System (ADS)

    Daum, Fred; Huang, Jim

    2007-09-01

    We derive and test a new nonlinear filter that implements Bayes' rule using an ODE rather than with a pointwise multiplication of two functions. This avoids one of the fundamental and well known problems in particle filters, namely "particle collapse" as a result of Bayes' rule. We use a log-homotopy to construct this ODE. Our new algorithm is vastly superior to the classic particle filter, and we do not use any proposal density supplied by an EKF or UKF or other outside source. This paper was written for normal engineers, who do not have homotopy for breakfast.

  15. Intensifying the Group Member's Experience Using the Group Log.

    ERIC Educational Resources Information Center

    Valine, Warren J.

    1983-01-01

    Presents the use of a group log in which members analyze the content and process of each session using a suggested format. The log promotes dialogue between the leader and each group member and involves members more fully in the group process. Feedback indicates the log is valuable. (JAC)

  16. Learning Logs in the Science Classroom: The Literacy Advantage

    ERIC Educational Resources Information Center

    Steenson, Cheryl

    2006-01-01

    In this article, the author discusses one of the most functional forms of writing to learn, the two-column learning logs. Two-column learning logs are based on the premise that collecting information and processing information are two very different aspects of learning. Two-column logs allow students to connect the facts and theories of science to…

  17. 46 CFR 131.620 - Matters that must be logged.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false Matters that must be logged. 131.620 Section 131.620 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OFFSHORE SUPPLY VESSELS OPERATIONS Logs § 131.620 Matters that must be logged. The following matters must be entered in each vessel's...

  18. 47 CFR 73.1840 - Retention of logs.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... by station licensees shall be retained by them for a period of 2 years. However, logs involving... inspection of logs pursuant to § 73.1226, availability to FCC of station logs and records. (2) Reproduction... any application; or placed in the station's local public inspection file as part of an application;...

  19. 47 CFR 73.1840 - Retention of logs.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... by station licensees shall be retained by them for a period of 2 years. However, logs involving... inspection of logs pursuant to § 73.1226, availability to FCC of station logs and records. (2) Reproduction... any application; or placed in the station's local public inspection file as part of an application;...

  20. 47 CFR 73.1840 - Retention of logs.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... by station licensees shall be retained by them for a period of 2 years. However, logs involving... inspection of logs pursuant to § 73.1226, availability to FCC of station logs and records. (2) Reproduction... any application; or placed in the station's local public inspection file as part of an application;...

  1. 47 CFR 73.1840 - Retention of logs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... by station licensees shall be retained by them for a period of 2 years. However, logs involving... inspection of logs pursuant to § 73.1226, availability to FCC of station logs and records. (2) Reproduction... any application; or placed in the station's local public inspection file as part of an application;...

  2. 47 CFR 73.1840 - Retention of logs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... by station licensees shall be retained by them for a period of 2 years. However, logs involving... inspection of logs pursuant to § 73.1226, availability to FCC of station logs and records. (2) Reproduction... any application; or placed in the station's local public inspection file as part of an application;...

  3. The Learning Log as an Integrated Instructional Assessment Tool.

    ERIC Educational Resources Information Center

    Topaz, Beverley

    1997-01-01

    Use of student learning logs is recommended as a means for both students and teacher to assess second-language learning. The approach encourages learners to analyze their learning difficulties and plan for overcoming them. Incorporated into portfolios, logs can be used to analyze progress. Sample log sheet and chart used as a framework for…

  4. 10 CFR 39.13 - Specific licenses for well logging.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Specific licenses for well logging. 39.13 Section 39.13 Energy NUCLEAR REGULATORY COMMISSION LICENSES AND RADIATION SAFETY REQUIREMENTS FOR WELL LOGGING Specific Licensing Requirements § 39.13 Specific licenses for well logging. The Commission will approve...

  5. 10 CFR 39.13 - Specific licenses for well logging.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Specific licenses for well logging. 39.13 Section 39.13 Energy NUCLEAR REGULATORY COMMISSION LICENSES AND RADIATION SAFETY REQUIREMENTS FOR WELL LOGGING Specific Licensing Requirements § 39.13 Specific licenses for well logging. The Commission will approve...

  6. 10 CFR 39.13 - Specific licenses for well logging.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Specific licenses for well logging. 39.13 Section 39.13 Energy NUCLEAR REGULATORY COMMISSION LICENSES AND RADIATION SAFETY REQUIREMENTS FOR WELL LOGGING Specific Licensing Requirements § 39.13 Specific licenses for well logging. The Commission will approve...

  7. Why, What, and How to Log? Lessons from LISTEN

    ERIC Educational Resources Information Center

    Mostow, Jack; Beck, Joseph E.

    2009-01-01

    The ability to log tutorial interactions in comprehensive, longitudinal, fine-grained detail offers great potential for educational data mining--but what data is logged, and how, can facilitate or impede the realization of that potential. We propose guidelines gleaned over 15 years of logging, exploring, and analyzing millions of events from…

  8. 10 CFR 39.13 - Specific licenses for well logging.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Specific licenses for well logging. 39.13 Section 39.13 Energy NUCLEAR REGULATORY COMMISSION LICENSES AND RADIATION SAFETY REQUIREMENTS FOR WELL LOGGING Specific Licensing Requirements § 39.13 Specific licenses for well logging. The Commission will approve...

  9. 10 CFR 39.13 - Specific licenses for well logging.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Specific licenses for well logging. 39.13 Section 39.13 Energy NUCLEAR REGULATORY COMMISSION LICENSES AND RADIATION SAFETY REQUIREMENTS FOR WELL LOGGING Specific Licensing Requirements § 39.13 Specific licenses for well logging. The Commission will approve...

  10. EFFECTS OF LOG HANDLING AND STORAGE ON WATER QUALITY

    EPA Science Inventory

    The biological and chemical effects of three types of log storage on water quality were investigated. Three flow-through log ponds, two wet deck operations, and five log rafting areas were studied. Both biological and chemical aspects of stream quality can be adversely affected b...

  11. Application of ALOGPS to predict 1-octanol/water distribution coefficients, logP, and logD, of AstraZeneca in-house database.

    PubMed

    Tetko, Igor V; Bruneau, Pierre

    2004-12-01

    The ALOGPS 2.1 was developed to predict 1-octanol/water partition coefficients, logP, and aqueous solubility of neutral compounds. An exclusive feature of this program is its ability to incorporate new user-provided data by means of self-learning properties of Associative Neural Networks. Using this feature, it calculated a similar performance, RMSE = 0.7 and mean average error 0.5, for 2569 neutral logP, and 8122 pH-dependent logD(7.4), distribution coefficients from the AstraZeneca "in-house" database. The high performance of the program for the logD(7.4) prediction looks surprising, because this property also depends on ionization constants pKa. Therefore, logD(7.4) is considered to be more difficult to predict than its neutral analog. We explain and illustrate this result and, moreover, discuss a possible application of the approach to calculate other pharmacokinetic and biological activities of chemicals important for drug development. PMID:15514985

  12. Log-Log Convexity of Type-Token Growth in Zipf's Systems

    NASA Astrophysics Data System (ADS)

    Font-Clos, Francesc; Corral, Álvaro

    2015-06-01

    It is traditionally assumed that Zipf's law implies the power-law growth of the number of different elements with the total number of elements in a system—the so-called Heaps' law. We show that a careful definition of Zipf's law leads to the violation of Heaps' law in random systems, with growth curves that have a convex shape in log-log scale. These curves fulfill universal data collapse that only depends on the value of Zipf's exponent. We observe that real books behave very much in the same way as random systems, despite the presence of burstiness in word occurrence. We advance an explanation for this unexpected correspondence.

  13. Biochemical analyses of the antioxidative activity and chemical ingredients in eight different Allium alien monosomic addition lines.

    PubMed

    Yaguchi, Shigenori; Matsumoto, Misato; Date, Rie; Harada, Kazuki; Maeda, Toshimichi; Yamauchi, Naoki; Shigyo, Masayoshi

    2013-01-01

    We measured the antioxidant contents and antioxidative activities in eight Allium fistulosum-shallot monosomic addition lines (MAL; FF+1A-FF+8A). The high antioxidative activity lines (FF+2A and FF+6A) showed high polyphenol accumulation. These additional chromosomes (2A and 6A) would therefore have anonymous genes related to the upregulation of polyphenol production, the antioxidative activities consequently being increased in these MALs. PMID:24317054

  14. Dual excitation acoustic paramagnetic logging tool

    DOEpatents

    Vail, III, William B.

    1989-01-01

    New methods and apparatus are disclosed which allow measurement of the presence of oil and water in gelogical formations using a new physical effect called the Acoustic Paramagnetic Logging Effect (APLE). The presence of petroleum in formation causes a slight increase in the earth's magnetic field in the vicinity of the reservoir. This is the phenomena of paramagnetism. Application of an acoustic source to a geological formation at the Larmor frequency of the nucleous present causes the paramagnetism of the formation to disappear. This results in a decrease in the earth's magnetic field in the vicinity of the oil bearing formation. Repetitively frequency sweeping the acoustic source through the Larmor frequency of the nucleons present (approx. 2 kHz) causes an amplitude modulation of the earth's magnetic field which is a consequence of the APLE. The amplitude modulation of the earth's magnetic field is measured with an induction coil gradiometer and provides a direct measure of the amount of oil and water in the excitation zone of the formation. The phase of the signal is used to infer the longitudinal relaxation times of the fluids present, which results in the ability in general to separate oil and water and to measure the viscosity of the oil present. Such measurements may be preformed in open boreholes and in cased well bores. The Dual Excitation Acoustic Paramagnetic Logging Tool employing two acoustic sources is also described.

  15. Method and apparatus for multipole acoustic logging

    SciTech Connect

    Chang, S.K.; Froelich, B.G.; Varga, G.

    1990-08-21

    This patent describes a logging tool for use in a borehole traversing an earth formation, the tool having a multiple dipole source connected to the tool in a fixed position and orientation to generate shear wave radiation in multiple directions in the formation upon excitation. It comprises: generating shear wave radiation in a first direction; receiving at each detector at least a portion of the generated shear wave in a second and a third direction; generating shear wave radiation in a fourth direction; receiving at each detector at least a portion of the generated shear wave in a fifth and a sixth direction; determining, for each detector, a composite dipole waveform for azimuthal directions based on at least a portion of the received waveforms in the second, third, fifth and sixth directions received at each detector; determining for each azimuthal direction, a shear wave velocity based on the composite dipole waveforms determined for each azimuthal direction; and obtaining the magnitude and direction of formation anisotropy, relative to the position of the logging tool.

  16. Log-Euclidean free-form deformation

    NASA Astrophysics Data System (ADS)

    Modat, Marc; Ridgway, Gerard R.; Daga, Pankaj; Cardoso, M. J.; Hawkes, David J.; Ashburner, John; Ourselin, Sébastien

    2011-03-01

    The Free-Form Deformation (FFD) algorithm is a widely used method for non-rigid registration. Modifications have previously been proposed to ensure topology preservation and invertibility within this framework. However, in practice, none of these yield the inverse transformation itself, and one loses the parsimonious B-spline parametrisation. We present a novel log-Euclidean FFD approach in which a spline model of a stationary velocity field is exponentiated to yield a diffeomorphism, using an efficient scaling-and-squaring algorithm. The log-Euclidean framework allows easy computation of a consistent inverse transformation, and offers advantages in group-wise atlas building and statistical analysis. We optimise the Normalised Mutual Information plus a regularisation term based on the Jacobian determinant of the transformation, and we present a novel analytical gradient of the latter. The proposed method has been assessed against a fast FFD implementation (F3D) using simulated T1- and T2-weighted magnetic resonance brain images. The overlap measures between propagated grey matter tissue probability maps used in the simulations show similar results for both approaches; however, our new method obtains more reasonable Jacobian values, and yields inverse transformations.

  17. Close-Call Action Log Form

    NASA Technical Reports Server (NTRS)

    Spuler, Linda M.; Ford, Patricia K.; Skeete, Darren C.; Hershman, Scot; Raviprakash, Pushpa; Arnold, John W.; Tran, Victor; Haenze, Mary Alice

    2005-01-01

    "Close Call Action Log Form" ("CCALF") is the name of both a computer program and a Web-based service provided by the program for creating an enhanced database of close calls (in the colloquial sense of mishaps that were avoided by small margins) assigned to the Center Operations Directorate (COD) at Johnson Space Center. CCALF provides a single facility for on-line collaborative review of close calls. Through CCALF, managers can delegate responses to employees. CCALF utilizes a pre-existing e-mail system to notify managers that there are close calls to review, but eliminates the need for the prior practices of passing multiple e-mail messages around the COD, then collecting and consolidating them into final responses: CCALF now collects comments from all responders for incorporation into reports that it generates. Also, whereas it was previously necessary to manually calculate metrics (e.g., numbers of maintenance-work orders necessitated by close calls) for inclusion in the reports, CCALF now computes the metrics, summarizes them, and displays them in graphical form. The reports and all pertinent information used to generate the reports are logged, tracked, and retained by CCALF for historical purposes.

  18. Dual excitation acoustic paramagnetic logging tool

    DOEpatents

    Vail, W.B. III.

    1989-02-14

    New methods and apparatus are disclosed which allow measurement of the presence of oil and water in geological formations using a new physical effect called the Acoustic Paramagnetic Logging Effect (APLE). The presence of petroleum in formation causes a slight increase in the earth's magnetic field in the vicinity of the reservoir. This is the phenomena of paramagnetism. Application of an acoustic source to a geological formation at the Larmor frequency of the nucleons present causes the paramagnetism of the formation to disappear. This results in a decrease in the earth's magnetic field in the vicinity of the oil bearing formation. Repetitively frequency sweeping the acoustic source through the Larmor frequency of the nucleons present (approx. 2 kHz) causes an amplitude modulation of the earth's magnetic field which is a consequence of the APLE. The amplitude modulation of the earth's magnetic field is measured with an induction coil gradiometer and provides a direct measure of the amount of oil and water in the excitation zone of the formation. The phase of the signal is used to infer the longitudinal relaxation times of the fluids present, which results in the ability in general to separate oil and water and to measure the viscosity of the oil present. Such measurements may be performed in open boreholes and in cased well bores. The Dual Excitation Acoustic Paramagnetic Logging Tool employing two acoustic sources is also described. 6 figs.

  19. Dewarless Logging Tool - 1st Generation

    SciTech Connect

    HENFLING,JOSEPH A.; NORMANN,RANDY A.

    2000-08-01

    This report focuses on Sandia National Laboratories' effort to create high-temperature logging tools for geothermal applications without the need for heat shielding. One of the mechanisms for failure in conventional downhole tools is temperature. They can only survive a limited number of hours in high temperature environments. For the first time since the evolution of integrated circuits, components are now commercially available that are qualified to 225 C with many continuing to work up to 300 C. These components are primarily based on Silicon-On-Insulator (SOI) technology. Sandia has developed and tested a simple data logger based on this technology that operates up to 300 C with a few limiting components operating to only 250 C without thermal protection. An actual well log to 240 C without shielding is discussed. The first prototype high-temperature tool measures pressure and temperature using a wire-line for power and communication. The tool is based around the HT83C51 microcontroller. A brief discussion of the background and status of the High Temperature Instrumentation program at Sandia, objectives, data logger development, and future project plans are given.

  20. Results of investigations at the Zunil geothermal field, Guatemala: Well logging and brine geochemistry

    SciTech Connect

    Adams, A.; Dennis, B.; Van Eeckhout, E.; Goff, F.; Lawton, R.; Trujillo, P.E.; Counce, D.; Archuleta, J. ); Medina, V. . Unidad de Desarollo Geotermico)

    1991-07-01

    The well logging team from Los Alamos and its counterpart from Central America were tasked to investigate the condition of four producing geothermal wells in the Zunil Geothermal Field. The information obtained would be used to help evaluate the Zunil geothermal reservoir in terms of possible additional drilling and future power plant design. The field activities focused on downhole measurements in four production wells (ZCQ-3, ZCQ-4, ZCQ-5, and ZCQ-6). The teams took measurements of the wells in both static (shut-in) and flowing conditions, using the high-temperature well logging tools developed at Los Alamos National Laboratory. Two well logging missions were conducted in the Zunil field. In October 1988 measurements were made in well ZCQ-3, ZCQ-5, and ZCQ-6. In December 1989 the second field operation logged ZCQ-4 and repeated logs in ZCQ-3. Both field operations included not only well logging but the collecting of numerous fluid samples from both thermal and nonthermal waters. 18 refs., 22 figs., 7 tabs.

  1. Coal log pipeline: Development status of the first commercial system

    SciTech Connect

    Marrero, T.R.

    1996-12-31

    The coal log pipeline (CLP) is an innovative means for long-distance transportation of coal. In the CLP concept, coal is pressed into the form of cylinders--coal logs--that are propelled by water flowing through underground pipe. A coal log pipeline has many advantages when compared to coal transport by unit train, slurry pipeline and long-distance trucking: low-cost, low energy consumption, low-water consumption, simple dewatering at pipeline exit, safe, and environmentally friendly. The coal logs travel butted together, as trains. Between the coal log {open_quotes}trains,{close_quotes} some space is allowed for valve switching. The optimum diameter of a coal log is approximately 90 to 95% the inside diameter of the pipe. The coal-to-water ratio is about 4 to 1. A 200 mm diameter CLP can transport about 2 million tonnes of coal per year. The coal logs at their destination come out of the pipeline onto a moving conveyer which transports the logs to a crusher or stock pile. Coal logs are crushed to match the size of existing fuel. The water effluent is treated and reused at the power plant; there is no need for its discharge. Coal logs can be manufactured with and without the use of binder. By using less than 2 percent emulsified asphalt as binder, no heat is required to compact coal logs. Binderless coal logs can be compacted at less than 90{degrees}C. Compaction pressures, for coal logs made with or without binder, are about 70 MPa. The coal particle size distribution and moisture content must be controlled. The economics of coal log pipeline system have been studied. Results indicate that a new coal log pipeline is cost-competitive with existing railroads for distances greater than 80 km, approximately. CLP is much more economical than coal slurry pipeline of the same diameter. This paper describes the current R&D and commercialization plan for CLP. 4 refs.

  2. « Les fleurs du MAL » une méthode d'ondelettes adaptive de lignes arbitraires I : problèmes de convection diffusion

    NASA Astrophysics Data System (ADS)

    Ren, Xiaoan; Xanthis, Leonidas S.

    2004-01-01

    Baudelaire's 'les fleurs du mal' refers to various new developments ('les fleurs') of the method ofarbitrarylines ( mal), since it was first published (in C. R. Acad. Sci. Paris, Sér. I, in 1991). Here we revisit the basic mal (semi-discretization) methodology for stationary convection-diffusion problems and develop an adaptive, wavelet-based solver that is capable of capturing the thin layers that arise in such problems. We show the efficacy and high accuracy of the wavelet-mal solver by applying it to a challenging 2D problem involving both boundary and interior layers. To cite this article: X. Ren, L.S. Xanthis, C. R. Mecanique 332 (2004).

  3. Parameter estimation and forecasting for multiplicative log-normal cascades.

    PubMed

    Leövey, Andrés E; Lux, Thomas

    2012-04-01

    We study the well-known multiplicative log-normal cascade process in which the multiplication of Gaussian and log normally distributed random variables yields time series with intermittent bursts of activity. Due to the nonstationarity of this process and the combinatorial nature of such a formalism, its parameters have been estimated mostly by fitting the numerical approximation of the associated non-Gaussian probability density function to empirical data, cf. Castaing et al. [Physica D 46, 177 (1990)]. More recently, alternative estimators based upon various moments have been proposed by Beck [Physica D 193, 195 (2004)] and Kiyono et al. [Phys. Rev. E 76, 041113 (2007)]. In this paper, we pursue this moment-based approach further and develop a more rigorous generalized method of moments (GMM) estimation procedure to cope with the documented difficulties of previous methodologies. We show that even under uncertainty about the actual number of cascade steps, our methodology yields very reliable results for the estimated intermittency parameter. Employing the Levinson-Durbin algorithm for best linear forecasts, we also show that estimated parameters can be used for forecasting the evolution of the turbulent flow. We compare forecasting results from the GMM and Kiyono et al.'s procedure via Monte Carlo simulations. We finally test the applicability of our approach by estimating the intermittency parameter and forecasting of volatility for a sample of financial data from stock and foreign exchange markets. PMID:22680545

  4. Use of historical logging patterns to identify disproportionately logged ecosystems within temperate rainforests of southeastern Alaska.

    PubMed

    Albert, David M; Schoen, John W

    2013-08-01

    The forests of southeastern Alaska remain largely intact and contain a substantial proportion of Earth's remaining old-growth temperate rainforest. Nonetheless, industrial-scale logging has occurred since the 1950s within a relatively narrow range of forest types that has never been quantified at a regional scale. We analyzed historical patterns of logging from 1954 through 2004 and compared the relative rates of change among forest types, landform associations, and biogeographic provinces. We found a consistent pattern of disproportionate logging at multiple scales, including large-tree stands and landscapes with contiguous productive old-growth forests. The highest rates of change were among landform associations and biogeographic provinces that originally contained the largest concentrations of productive old growth (i.e., timber volume >46.6 m³/ha). Although only 11.9% of productive old-growth forests have been logged region wide, large-tree stands have been reduced by at least 28.1%, karst forests by 37%, and landscapes with the highest volume of contiguous old growth by 66.5%. Within some island biogeographic provinces, loss of rare forest types may place local viability of species dependent on old growth at risk of extirpation. Examination of historical patterns of change among ecological forest types can facilitate planning for conservation of biodiversity and sustainable use of forest resources. PMID:23866037

  5. Regularized Multitask Learning for Multidimensional Log-Density Gradient Estimation.

    PubMed

    Yamane, Ikko; Sasaki, Hiroaki; Sugiyama, Masashi

    2016-07-01

    Log-density gradient estimation is a fundamental statistical problem and possesses various practical applications such as clustering and measuring nongaussianity. A naive two-step approach of first estimating the density and then taking its log gradient is unreliable because an accurate density estimate does not necessarily lead to an accurate log-density gradient estimate. To cope with this problem, a method to directly estimate the log-density gradient without density estimation has been explored and demonstrated to work much better than the two-step method. The objective of this letter is to improve the performance of this direct method in multidimensional cases. Our idea is to regard the problem of log-density gradient estimation in each dimension as a task and apply regularized multitask learning to the direct log-density gradient estimator. We experimentally demonstrate the usefulness of the proposed multitask method in log-density gradient estimation and mode-seeking clustering. PMID:27171983

  6. Method for induced gamma ray logging

    SciTech Connect

    Randall, R.R.

    1987-02-24

    This patent describes a nuclear well logging operation. A method is described for determining a parameter responsive to the condition of a borehole transversing a subsurface earth formation, comprising the steps of: cyclically irradiating the subsurface earth formation with bursts of high energy neutrons; detecting for one or more burst cycles the impingement of gamma radiation upon a first gamma radiation detector means during and between each of the bursts; determining first count of detected impingements of primarily inelastic gamma radiation upon the first detection means; and normalizing the first count to remove the effects upon the first count of variations in the bursts of high energy neutrons, the normalized first count producing the parameter responsive to the condition of the borehole.

  7. Method for induced gamma ray logging

    SciTech Connect

    Randall, R.R.

    1987-04-07

    In a nuclear well logging operation, a method is described for indicating the presence of gas in a fluid filled zone of a subsurface earth formation, comprising the steps of: cyclically irradiating the subsurface earth formation with bursts of high energy neutrons; detecting for one or more burst cycles the impingement of gamma radiation upon a first gamma radiation detector means during and between each of the burst; determining a first parameter indicative of the count of detected impingements of primarily inelastic gamma radiation upon the first detector means; determining a second parameter indicative of the count of detected impingements of primarily capture gamma radiation upon the first detector means; and comparing the first and second parameters to determine the presence of gas.

  8. Simulation Control Graphical User Interface Logging Report

    NASA Technical Reports Server (NTRS)

    Hewling, Karl B., Jr.

    2012-01-01

    One of the many tasks of my project was to revise the code of the Simulation Control Graphical User Interface (SIM GUI) to enable logging functionality to a file. I was also tasked with developing a script that directed the startup and initialization flow of the various LCS software components. This makes sure that a software component will not spin up until all the appropriate dependencies have been configured properly. Also I was able to assist hardware modelers in verifying the configuration of models after they have been upgraded to a new software version. I developed some code that analyzes the MDL files to determine if any error were generated due to the upgrade process. Another one of the projects assigned to me was supporting the End-to-End Hardware/Software Daily Tag-up meeting.

  9. Armored instrumentation cable for geothermal well logging

    SciTech Connect

    Dennis, B.R.; Johnson, J.; Todd, B.

    1981-01-01

    Multiconductor armored well-logging cable is used extensively by the oil and natural gas industry to lower various instruments used to measure the geological and geophysical parameters into deep wellbores. Advanced technology in oil-well drilling makes it possible to achieve borehole depths of 9 km (30,000 ft). The higher temperatures in these deeper boreholes demand advancements in the design and manufacturing of wireline cable and in the electrical insulating and armoring materials used as integral components. If geothermal energy is proved an abundant economic resource, drilling temperatures approaching and exceeding 300/sup 0/C will become commonplace. The adaptation of teflons as electrical insulating material permitted use of armored cable in geothermal wellbores where temperatures are slightly in excess of 200/sup 0/C, and where the concentrations of corrosive minerals and gases are high. Teflon materials presently used in wireline cables, however, are not capable of continuous operation at the anticipated higher temperatures.

  10. Tolerance bounds for log gamma regression models

    NASA Technical Reports Server (NTRS)

    Jones, R. A.; Scholz, F. W.; Ossiander, M.; Shorack, G. R.

    1985-01-01

    The present procedure for finding lower confidence bounds for the quantiles of Weibull populations, on the basis of the solution of a quadratic equation, is more accurate than current Monte Carlo tables and extends to any location-scale family. It is shown that this method is accurate for all members of the log gamma(K) family, where K = 1/2 to infinity, and works well for censored data, while also extending to regression data. An even more accurate procedure involving an approximation to the Lawless (1982) conditional procedure, with numerical integrations whose tables are independent of the data, is also presented. These methods are applied to the case of failure strengths of ceramic specimens from each of three billets of Si3N4, which have undergone flexural strength testing.

  11. Squirt flow influence on sonic log parameters

    NASA Astrophysics Data System (ADS)

    Markova, I.; Ronquillo Jarillo, G.; Markov, M.; Gurevich, B.

    2014-02-01

    Most sedimentary rocks contain movable fluid in the pores. Hydrodynamic effects due to wave-induced oscillatory fluid flow can lead to significant changes of velocities and attenuations of elastic waves in these rocks. In this paper, we consider the influence of a squirt flow (local flow between the pores of different compressibility) on the sonic log response. The calculations are performed using a unified model describing the joint influence of squirt flow and Biot's global flow. The results show that the influence of the squirt flow increases with increase of a signal frequency. This influence is relatively small in the case of the Stoneley wave but it is significant in the case of P and S waves.

  12. Recombinant Mal d 1 facilitates sublingual challenge tests of birch pollen-allergic patients with apple allergy

    PubMed Central

    Kinaciyan, T.; Nagl, B.; Faustmann, S.; Kopp, S.; Wolkersdorfer, M.; Bohle, B.

    2015-01-01

    It is still unclear whether allergen-specific immunotherapy (AIT) with birch pollen improves birch pollen-related food allergy. One reason for this may be the lack of standardized tests to assess clinical reactions to birch pollen-related foods, for example apple. We tested the applicability of recombinant (r) Mal d 1, the Bet v 1-homolog in apple, for oral challenge tests. Increasing concentrations of rMal d 1 in 0.9% NaCl were sublingually administered to 72 birch pollen-allergic patients with apple allergy. The dose of 1.6 μg induced oral allergy syndromes in 26.4%, 3.2 μg in 15.3%, 6.3 μg in 27.8%, 12.5 μg in 8.3%, 25 μg in 11.1%, and 50 μg in 4.2% of the patients. No severe reactions occurred. None of the patients reacted to 0.9% NaCl alone. Sublingual administration of 50 μg of rMal d 1 induced no reactions in three nonallergic individuals. Our approach allows straight forward, dose-defined sublingual challenge tests in a high number of birch pollen-allergic patients that inter alia can be applied to evaluate the therapeutic efficacy of birch pollen AIT on birch pollen-related food allergy. PMID:26443126

  13. Recombinant Mal d 1 facilitates sublingual challenge tests of birch pollen-allergic patients with apple allergy.

    PubMed

    Kinaciyan, T; Nagl, B; Faustmann, S; Kopp, S; Wolkersdorfer, M; Bohle, B

    2016-02-01

    It is still unclear whether allergen-specific immunotherapy (AIT) with birch pollen improves birch pollen-related food allergy. One reason for this may be the lack of standardized tests to assess clinical reactions to birch pollen-related foods, for example apple. We tested the applicability of recombinant (r) Mal d 1, the Bet v 1-homolog in apple, for oral challenge tests. Increasing concentrations of rMal d 1 in 0.9% NaCl were sublingually administered to 72 birch pollen-allergic patients with apple allergy. The dose of 1.6 μg induced oral allergy syndromes in 26.4%, 3.2 μg in 15.3%, 6.3 μg in 27.8%, 12.5 μg in 8.3%, 25 μg in 11.1%, and 50 μg in 4.2% of the patients. No severe reactions occurred. None of the patients reacted to 0.9% NaCl alone. Sublingual administration of 50 μg of rMal d 1 induced no reactions in three nonallergic individuals. Our approach allows straight forward, dose-defined sublingual challenge tests in a high number of birch pollen-allergic patients that inter alia can be applied to evaluate the therapeutic efficacy of birch pollen AIT on birch pollen-related food allergy. PMID:26443126

  14. Investigation of the physical properties of the tetragonal CeMAl4Si2 (M = Rh, Ir, Pt) compounds

    DOE PAGESBeta

    Ghimire, N. J.; Ronning, F.; Williams, D. J.; Scott, B. L.; Luo, Yongkang; Thompson, J. D.; Bauer, E. D.

    2014-12-15

    The synthesis, crystal structure and physical properties studied by means of x-ray diffraction, magnetic, thermal and transport measurements of CeMAl4Si2 (M = Rh, Ir, Pt) are reported, along with the electronic structure calculations for LaMAl4Si2 (M = Rh, Ir, Pt). These materials adopt a tetragonal crystal structure (space group P4/mmm) comprised of BaAl4 blocks, separated by MAl2 units, stacked along the c-axis. Both CeRhAl4Si2 and CeIrAl4Si2 order antiferromagnetically below TN1 = 14 and 16 K, respectively, and undergo a second antiferromagnetic transitition at lower temperature (TN2 = 9 and 14 K, respectively). CePtAl4Si2 orders ferromagnetically below TC = 3 Kmore » with an ordered moment of μsat = 0.8 μB for a magnetic field applied perpendicular to the c-axis. Electronic structure calculations reveal quasi-2D character of the Fermi surface.« less

  15. Sequential and compartmentalized action of Rabs, SNAREs, and MAL in the apical delivery of fusiform vesicles in urothelial umbrella cells

    PubMed Central

    Wankel, Bret; Ouyang, Jiangyong; Guo, Xuemei; Hadjiolova, Krassimira; Miller, Jeremy; Liao, Yi; Tham, Daniel Kai Long; Romih, Rok; Andrade, Leonardo R.; Gumper, Iwona; Simon, Jean-Pierre; Sachdeva, Rakhee; Tolmachova, Tanya; Seabra, Miguel C.; Fukuda, Mitsunori; Schaeren-Wiemers, Nicole; Hong, Wan Jin; Sabatini, David D.; Wu, Xue-Ru; Kong, Xiangpeng; Kreibich, Gert; Rindler, Michael J.; Sun, Tung-Tien

    2016-01-01

    Uroplakins (UPs) are major differentiation products of urothelial umbrella cells and play important roles in forming the permeability barrier and in the expansion/stabilization of the apical membrane. Further, UPIa serves as a uropathogenic Escherichia coli receptor. Although it is understood that UPs are delivered to the apical membrane via fusiform vesicles (FVs), the mechanisms that regulate this exocytic pathway remain poorly understood. Immunomicroscopy of normal and mutant mouse urothelia show that the UP-delivering FVs contained Rab8/11 and Rab27b/Slac2-a, which mediate apical transport along actin filaments. Subsequently a Rab27b/Slp2-a complex mediated FV–membrane anchorage before SNARE-mediated and MAL-facilitated apical fusion. We also show that keratin 20 (K20), which forms a chicken-wire network ∼200 nm below the apical membrane and has hole sizes allowing FV passage, defines a subapical compartment containing FVs primed and strategically located for fusion. Finally, we show that Rab8/11 and Rab27b function in the same pathway, Rab27b knockout leads to uroplakin and Slp2-a destabilization, and Rab27b works upstream from MAL. These data support a unifying model in which UP cargoes are targeted for apical insertion via sequential interactions with Rabs and their effectors, SNAREs and MAL, and in which K20 plays a key role in regulating vesicular trafficking. PMID:27009205

  16. Idaho National Laboratory PCB Annual Document Log and Annual Records Report for Calendar Year 2013

    SciTech Connect

    no name on report

    2014-06-01

    The requirements for the reporting of polychlorinated biphenyl (PCB)-related activities are found in 40 Code of Federal Regulations (CFR) 761 Subpart J, "General Records and Reports." The PCB Annual Document Log is a detailed record of the PCB waste handling activities at the facility. The facility must prepare it each year by July 1 and maintain it at the facility for at least 3 years after the facility ceases using or storing PCBs and PCB items. While submittal of the PCB Annual Document Log to the U.S. Environmental Protection Agency (EPA) is not required by regulation, EPA has verbally requested in telephone conversations that this report be submitted to them on an annual basis. The Annual Document Log section of this report meets the requirements of 40 CFR 761.180(a)(2), as applicable, while the Annual Records section meets the requirement of 40 CFR 761.180(a)(1).

  17. Immunohistological study of tight junction protein expression in mal de Meleda.

    PubMed

    Kacem, Monia; Agili, Faouzia; Tounsi, Haifa; Zribi, Hela; Zaraa, Ines; Mokni, Mourad; Boubaker, Samir

    2016-01-01

    Mal de Meleda (MdM, MIM: 248300) is a rare autosomal recessive skin disorder characterized by diffuse palmoplantar keratoderma and transgressive keratosis with onset in early infancy. The gene responsible for MdM, ARS, encodes for Secreted Lys6/Plaur domain-containing protein 1 which is essential for epidermal homeostasis. Tight junctions have been proposed to have two mutually exclusive functions: a fence function which prevents the mixing of membrane proteins between the apical and basolateral membranes; and a gate function which controls the paracellular passage of ions and solutes between cells. In this study we report immunohistochemical investigations of tight junction proteins claudin-1 and occludin in MdM Tunisian families. Nine skin biopsies from patients with MdM were analyzed. The control group was formed by skin biopsies belonging to healthy individuals. Immunohistochemical study was performed on fixed sections from biopsies of four microns with the following polyclonal antibodies: anti-claudin-1 and anti-occludin. In control skin, claudin-1 exhibited membrane expression throughout the epidermis with increasing and upward intensity, whereas occludin was detected in the cell membrane of keratinocytes of the stratum granulosum. In MdM skin, claudin-1 was expressed throughout the thickness of the spinous layers with membrane staining, and occludin had cytoplasmic staining in the granular layer. The immunohistochemical expression of TJ proteins in MdM patients harbors premature expression of occludin and decreased expression of claudin-1, highlighting further evidence for disorders in epidermal homeostasis. PMID:26986447

  18. Santa Clara de Nanay: the MAL-ED cohort in Peru.

    PubMed

    Yori, Pablo Peñataro; Lee, Gwenyth; Olórtegui, Maribel Paredes; Chávez, César Banda; Flores, Julian Torres; Vasquez, Angel Orbe; Burga, Rosa; Pinedo, Silvia Rengifo; Asayag, César Ramal; Black, Robert E; Caulfield, Laura E; Kosek, Margaret

    2014-11-01

    The Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) cohort study communities in Peru are located in Loreto province, in a rural area 15 km from the city of Iquitos. This riverine population of approximately 5000 individuals is fairly representative of Loreto. The province lags behind the rest of the country in access to water and sanitation, per capita income, and key health indicators including infant mortality (43.0 vs 16.0 per 1000 nationwide) and under-5 mortality (60.6 vs 21.0 per 1000). Total fertility rates are higher than elsewhere in the country (4.3 vs 2.6). Nationwide, the prevalence of human immunodeficiency virus is estimated at 0.45%, the prevalence of tuberculosis is 117 per 100 000, and the incidence of malaria is 258 per 100 000. Stunting in this community is high, whereas acute undernutrition is relatively uncommon. The population suffers from high rates of diarrheal disease. Prevalent enteric pathogens include Ascaris, Giardia, enterotoxigenic Escherichia coli, Shigella, and Campylobacter. PMID:25305303

  19. Intelligent approaches for the synthesis of petrophysical logs

    NASA Astrophysics Data System (ADS)

    Rezaee, M. Reza; Kadkhodaie-Ilkhchi, Ali; Alizadeh, Pooya Mohammad

    2008-03-01

    Log data are of prime importance in acquiring petrophysical data from hydrocarbon reservoirs. Reliable log analysis in a hydrocarbon reservoir requires a complete set of logs. For many reasons, such as incomplete logging in old wells, destruction of logs due to inappropriate data storage and measurement errors due to problems with logging apparatus or hole conditions, log suites are either incomplete or unreliable. In this study, fuzzy logic and artificial neural networks were used as intelligent tools to synthesize petrophysical logs including neutron, density, sonic and deep resistivity. The petrophysical data from two wells were used for constructing intelligent models in the Fahlian limestone reservoir, Southern Iran. A third well from the field was used to evaluate the reliability of the models. The results showed that fuzzy logic and artificial neural networks were successful in synthesizing wireline logs. The combination of the results obtained from fuzzy logic and neural networks in a simple averaging committee machine (CM) showed a significant improvement in the accuracy of the estimations. This committee machine performed better than fuzzy logic or the neural network model in the problem of estimating petrophysical properties from well logs.

  20. Effects of logging and recruitment on community phylogenetic structure in 32 permanent forest plots of Kampong Thom, Cambodia.

    PubMed

    Toyama, Hironori; Kajisa, Tsuyoshi; Tagane, Shuichiro; Mase, Keiko; Chhang, Phourin; Samreth, Vanna; Ma, Vuthy; Sokh, Heng; Ichihashi, Ryuji; Onoda, Yusuke; Mizoue, Nobuya; Yahara, Tetsukazu

    2015-02-19

    Ecological communities including tropical rainforest are rapidly changing under various disturbances caused by increasing human activities. Recently in Cambodia, illegal logging and clear-felling for agriculture have been increasing. Here, we study the effects of logging, mortality and recruitment of plot trees on phylogenetic community structure in 32 plots in Kampong Thom, Cambodia. Each plot was 0.25 ha; 28 plots were established in primary evergreen forests and four were established in secondary dry deciduous forests. Measurements were made in 1998, 2000, 2004 and 2010, and logging, recruitment and mortality of each tree were recorded. We estimated phylogeny using rbcL and matK gene sequences and quantified phylogenetic α and β diversity. Within communities, logging decreased phylogenetic diversity, and increased overall phylogenetic clustering and terminal phylogenetic evenness. Between communities, logging increased phylogenetic similarity between evergreen and deciduous plots. On the other hand, recruitment had opposite effects both within and between communities. The observed patterns can be explained by environmental homogenization under logging. Logging is biased to particular species and larger diameter at breast height, and forest patrol has been effective in decreasing logging. PMID:25561669

  1. Effects of logging and recruitment on community phylogenetic structure in 32 permanent forest plots of Kampong Thom, Cambodia

    PubMed Central

    Toyama, Hironori; Kajisa, Tsuyoshi; Tagane, Shuichiro; Mase, Keiko; Chhang, Phourin; Samreth, Vanna; Ma, Vuthy; Sokh, Heng; Ichihashi, Ryuji; Onoda, Yusuke; Mizoue, Nobuya; Yahara, Tetsukazu

    2015-01-01

    Ecological communities including tropical rainforest are rapidly changing under various disturbances caused by increasing human activities. Recently in Cambodia, illegal logging and clear-felling for agriculture have been increasing. Here, we study the effects of logging, mortality and recruitment of plot trees on phylogenetic community structure in 32 plots in Kampong Thom, Cambodia. Each plot was 0.25 ha; 28 plots were established in primary evergreen forests and four were established in secondary dry deciduous forests. Measurements were made in 1998, 2000, 2004 and 2010, and logging, recruitment and mortality of each tree were recorded. We estimated phylogeny using rbcL and matK gene sequences and quantified phylogenetic α and β diversity. Within communities, logging decreased phylogenetic diversity, and increased overall phylogenetic clustering and terminal phylogenetic evenness. Between communities, logging increased phylogenetic similarity between evergreen and deciduous plots. On the other hand, recruitment had opposite effects both within and between communities. The observed patterns can be explained by environmental homogenization under logging. Logging is biased to particular species and larger diameter at breast height, and forest patrol has been effective in decreasing logging. PMID:25561669

  2. malT knockout mutation invokes a stringent type gene-expression profile in Actinobacillus pleuropneumoniae in bronchoalveolar fluid

    PubMed Central

    2009-01-01

    Background Actinobacillus pleuropneumoniae causes contagious pleuropneumonia, an economically important disease of commercially reared pigs throughout the world. To cause this disease, A. pleuropneumoniae must rapidly overcome porcine pulmonary innate immune defenses. Since bronchoalveolar fluid (BALF) contains many of the innate immune and other components found in the lungs, we examined the gene expression of a virulent serovar 1 strain of A. pleuropneumoniae after exposure to concentrated BALF for 30 min. Results In reverse transcription PCR differential display (RT-PCR DD) experiments, A. pleuropneumoniae CM5 exposed to BALF up-regulated, among other genes, a gene predicted to encode LamB, an outer-membrane transport protein of the maltose regulon. To determine the role of the lamB and other genes of the maltose regulon in the pathogenesis of A. pleuropneumoniae, knockout mutations were created in the lamB and malT genes, the latter being the positive transcriptional regulator of the maltose regulon. Relative to the lamB mutant and the wild type, the malT mutant had a significant (P < 0.05) decrease in growth rate and an increased sensitivity to fresh porcine serum and high concentrations (more than 0.5 M) of sodium chloride. In DNA microarray experiments, the BALF-exposed malT mutant exhibited a gene-expression profile resembling that of a stringent type gene-expression profile seen in bacteria facing amino acid or carbon starvation. Genes encoding proteins for protein synthesis, energy metabolism, and DNA replication were down-regulated, while genes involved in stringent response (e.g., relA), amino acid and nucleotide biosynthesis, biofilm formation, DNA transformation, and stress response were up-regulated. Conclusion These results suggest that MalT may be involved in protection against some stressors and in the transport of one or more essential nutrients in BALF. Moreover, if MalT is directly or indirectly linked to the stringent response, an important

  3. Development of a glacially dominated shelf-slope-fan system in tectonically active southeast Alaska: Results of IODP Expedition 341 core-log-seismic integrated studies at glacial cycle resolution

    NASA Astrophysics Data System (ADS)

    Gulick, Sean; Jaeger, John; Mix, Alan; Swartz, John; Worthington, Lindsay; Reece, Robert

    2014-05-01

    Collision of the Yakutat microplate with North American formed the St. Elias Mountains in coastal Gulf of Alaska. While the tectonic driver for orogenesis has been ongoing since the Miocene, results from the Integrated Ocean Drilling Program Expedition 341 suggests that direct climatic perturbation of active orogenesis through glacial erosion is non-linear. Geophysical studies of the glaciated continental margin, slope, and adjacent deep-sea Surveyor Fan allow examination of the glaciated orogen from source to sink. Using high-resolution and crustal-scale seismic data and through comparison with other glaciated margins, we can identify key diagnostic seismic morphologies and facies indicative of glacial proximity and sediment routing. Expedition drilling results calibrated these images suggesting a timeline for initial advances of the Cordilleran ice sheet related glacial systems onto the shelf and a further timeline for the development of ice streams that reach the shelf edge. Comparisons can be made within this single margin between evolution of the tectonic-glacial system where erosion and sediment transport are occurring within a fold and thrust belt versus on a more stable shelf region. Onshore the Bering-Bagley glacial system in the west flows across the Yakataga fold and thrust belt, allowing examination of whether glacial erosion can cause tectonic feedbacks, whereas offshore the Bering-Bagley system interacts with the Pamplona Zone thrusts in a region of significant sediment accommodation. Results from Expedition 341 imply that timing of glacial advance to the shelf edge in this region may be driven by the necessity of filling up the accommodation through aggradation followed by progradation and thus is autogenic. In contrast the Malaspina-Hubbard glacial system to the east encountered significantly less accommodation and more directly responded to climatic forcing including showing outer shelf glacial occupation since the mid-Pleistocene transition-MPT to

  4. Fluorescence and phosphorescence properties of the low temperature forms of the MAl{sub 2}Si{sub 2}O{sub 8}:Eu{sup 2+} (M=Ca, Sr, Ba) compounds

    SciTech Connect

    Clabau, Frederic; Garcia, Alain; Bonville, Pierre; Gonbeau, Danielle; Le Mercier, Thierry; Deniard, Philippe; Jobic, Stephane

    2008-06-15

    The fluorescence and phosphorescence properties of Europium-doped MAl{sub 2}Si{sub 2}O{sub 8} (M=Ca, Sr, Ba) are reinvestigated and discussed on the basis of the propensity of an activator to agglomerate with an oxygen vacancy. Due to a stronger attraction of the anion vacancy towards Eu{sup 2+} cations going from BaAl{sub 2}Si{sub 2}O{sub 8} to SrAl{sub 2}Si{sub 2}O{sub 8} and CaAl{sub 2}Si{sub 2}O{sub 8} host lattices, the interpretation of the fluorescence spectra turns out to be less trivial in the Ca and Sr host lattices than in the Ba one and requests the account for Eu{sup 2+} cations lying at alkaline-earth sites with or without vacancy in their neighborhood. Phosphorescence in these compounds is highlighted. - Graphical abstract: The Eu{sup 2+}-doped MAl{sub 2}Si{sub 2}O{sub 8} (M=Ca, Sr, and Ba) aluminosilicates exhibit a bluish white luminescence, which can last several minutes after the removal of the excitation. The account for Eu{sup 2+} cations coupled with defects is required to explain fluorescence spectra.

  5. Nut Production in Bertholletia excelsa across a Logged Forest Mosaic: Implications for Multiple Forest Use

    PubMed Central

    Rockwell, Cara A.; Guariguata, Manuel R.; Menton, Mary; Arroyo Quispe, Eriks; Quaedvlieg, Julia; Warren-Thomas, Eleanor; Fernandez Silva, Harol; Jurado Rojas, Edwin Eduardo; Kohagura Arrunátegui, José Andrés Hideki; Meza Vega, Luis Alberto; Revilla Vera, Olivia; Valera Tito, Jonatan Frank; Villarroel Panduro, Betxy Tabita; Yucra Salas, Juan José

    2015-01-01

    Although many examples of multiple-use forest management may be found in tropical smallholder systems, few studies provide empirical support for the integration of selective timber harvesting with non-timber forest product (NTFP) extraction. Brazil nut (Bertholletia excelsa, Lecythidaceae) is one of the world’s most economically-important NTFP species extracted almost entirely from natural forests across the Amazon Basin. An obligate out-crosser, Brazil nut flowers are pollinated by large-bodied bees, a process resulting in a hard round fruit that takes up to 14 months to mature. As many smallholders turn to the financial security provided by timber, Brazil nut fruits are increasingly being harvested in logged forests. We tested the influence of tree and stand-level covariates (distance to nearest cut stump and local logging intensity) on total nut production at the individual tree level in five recently logged Brazil nut concessions covering about 4000 ha of forest in Madre de Dios, Peru. Our field team accompanied Brazil nut harvesters during the traditional harvest period (January-April 2012 and January-April 2013) in order to collect data on fruit production. Three hundred and ninety-nine (approximately 80%) of the 499 trees included in this study were at least 100 m from the nearest cut stump, suggesting that concessionaires avoid logging near adult Brazil nut trees. Yet even for those trees on the edge of logging gaps, distance to nearest cut stump and local logging intensity did not have a statistically significant influence on Brazil nut production at the applied logging intensities (typically 1–2 timber trees removed per ha). In one concession where at least 4 trees ha-1 were removed, however, the logging intensity covariate resulted in a marginally significant (0.09) P value, highlighting a potential risk for a drop in nut production at higher intensities. While we do not suggest that logging activities should be completely avoided in Brazil nut rich

  6. Nut Production in Bertholletia excelsa across a Logged Forest Mosaic: Implications for Multiple Forest Use.

    PubMed

    Rockwell, Cara A; Guariguata, Manuel R; Menton, Mary; Arroyo Quispe, Eriks; Quaedvlieg, Julia; Warren-Thomas, Eleanor; Fernandez Silva, Harol; Jurado Rojas, Edwin Eduardo; Kohagura Arrunátegui, José Andrés Hideki; Meza Vega, Luis Alberto; Revilla Vera, Olivia; Quenta Hancco, Roger; Valera Tito, Jonatan Frank; Villarroel Panduro, Betxy Tabita; Yucra Salas, Juan José

    2015-01-01

    Although many examples of multiple-use forest management may be found in tropical smallholder systems, few studies provide empirical support for the integration of selective timber harvesting with non-timber forest product (NTFP) extraction. Brazil nut (Bertholletia excelsa, Lecythidaceae) is one of the world's most economically-important NTFP species extracted almost entirely from natural forests across the Amazon Basin. An obligate out-crosser, Brazil nut flowers are pollinated by large-bodied bees, a process resulting in a hard round fruit that takes up to 14 months to mature. As many smallholders turn to the financial security provided by timber, Brazil nut fruits are increasingly being harvested in logged forests. We tested the influence of tree and stand-level covariates (distance to nearest cut stump and local logging intensity) on total nut production at the individual tree level in five recently logged Brazil nut concessions covering about 4000 ha of forest in Madre de Dios, Peru. Our field team accompanied Brazil nut harvesters during the traditional harvest period (January-April 2012 and January-April 2013) in order to collect data on fruit production. Three hundred and ninety-nine (approximately 80%) of the 499 trees included in this study were at least 100 m from the nearest cut stump, suggesting that concessionaires avoid logging near adult Brazil nut trees. Yet even for those trees on the edge of logging gaps, distance to nearest cut stump and local logging intensity did not have a statistically significant influence on Brazil nut production at the applied logging intensities (typically 1-2 timber trees removed per ha). In one concession where at least 4 trees ha-1 were removed, however, the logging intensity covariate resulted in a marginally significant (0.09) P value, highlighting a potential risk for a drop in nut production at higher intensities. While we do not suggest that logging activities should be completely avoided in Brazil nut rich

  7. The logN-logS relationship of normal X-ray emitting galaxies

    NASA Astrophysics Data System (ADS)

    Tajer, M.; Trinchieri, G.; Wolter A.; Campana, S.; Moretti, A.; Tagliaferri, G.

    We have selected a flux limited serendipitous sample of galaxies from the cross-correlation of the BMW (Brera Multiscale Wavelet) ROSAT HRI and the LEDA (Lyon - Meudon Extragalactic Database) Catalogues. This sample is used to study the X-ray properties of normal galaxies in the local universe. We also find that the logN-logS distribution we derived for a serendipitous subsample, optically and X-ray flux limited, is consistent with the euclidean slope in the flux range FX(0.5 - 2) ˜ 1.1 - 110 × 10-14 erg cm-2 s-1. We further show that the same law is valid over 4 decades, from the bright sample derived from the RASS data to the very faint detections in deep XMM-Newton fields.

  8. Certified and Uncertified Logging Concessions Compared in Gabon: Changes in Stand Structure, Tree Species, and Biomass

    NASA Astrophysics Data System (ADS)

    Medjibe, V. P.; Putz, Francis E.; Romero, Claudia

    2013-03-01

    Forest management certification is assumed to promote sustainable forest management, but there is little field-based evidence to support this claim. To help fill this gap, we compared a Forest Stewardship Council (FSC)-certified with an adjacent uncertified, conventionally logged concession (CL) in Gabon on the basis of logging damage, above-ground biomass (AGB), and tree species diversity and composition. Before logging, we marked, mapped, and measured all trees >10 cm dbh in 20 and twelve 1-ha permanent plots in the FSC and CL areas, respectively. Soil and tree damage due to felling, skidding, and road-related activities was then assessed 2-3 months after the 508 ha FSC study area and the 200 ha CL study area were selectively logged at respective intensities of 5.7 m3/ha (0.39 trees/ha) and 11.4 m3/ha (0.76 trees/ha). For each tree felled, averages of 9.1 and 20.9 other trees were damaged in the FSC and CL plots, respectively; when expressed as the impacts per timber volume extracted, the values did not differ between the two treatments. Skid trails covered 2.9 % more of the CL surface, but skid trail length per unit timber volume extracted was not greater. Logging roads were wider in the CL than FSC site and disturbed 4.7 % more of the surface. Overall, logging caused declines in AGB of 7.1 and 13.4 % at the FSC and CL sites, respectively. Changes in tree species composition were small but greater for the CL site. Based on these findings and in light of the pseudoreplicated study design with less-than perfect counterfactual, we cautiously conclude that certification yields environmental benefits even after accounting for differences in logging intensities.

  9. Certified and uncertified logging concessions compared in Gabon: changes in stand structure, tree species, and biomass.

    PubMed

    Medjibe, V P; Putz, Francis E; Romero, Claudia

    2013-03-01

    Forest management certification is assumed to promote sustainable forest management, but there is little field-based evidence to support this claim. To help fill this gap, we compared a Forest Stewardship Council (FSC)-certified with an adjacent uncertified, conventionally logged concession (CL) in Gabon on the basis of logging damage, above-ground biomass (AGB), and tree species diversity and composition. Before logging, we marked, mapped, and measured all trees >10 cm dbh in 20 and twelve 1-ha permanent plots in the FSC and CL areas, respectively. Soil and tree damage due to felling, skidding, and road-related activities was then assessed 2-3 months after the 508 ha FSC study area and the 200 ha CL study area were selectively logged at respective intensities of 5.7 m(3)/ha (0.39 trees/ha) and 11.4 m(3)/ha (0.76 trees/ha). For each tree felled, averages of 9.1 and 20.9 other trees were damaged in the FSC and CL plots, respectively; when expressed as the impacts per timber volume extracted, the values did not differ between the two treatments. Skid trails covered 2.9 % more of the CL surface, but skid trail length per unit timber volume extracted was not greater. Logging roads were wider in the CL than FSC site and disturbed 4.7 % more of the surface. Overall, logging caused declines in AGB of 7.1 and 13.4 % at the FSC and CL sites, respectively. Changes in tree species composition were small but greater for the CL site. Based on these findings and in light of the pseudoreplicated study design with less-than perfect counterfactual, we cautiously conclude that certification yields environmental benefits even after accounting for differences in logging intensities. PMID:23277438

  10. Landscape-scale changes in forest canopy structure across a partially logged tropical peat swamp

    NASA Astrophysics Data System (ADS)

    Wedeux, B. M. M.; Coomes, D. A.

    2015-11-01

    Forest canopy structure is strongly influenced by environmental factors and disturbance, and in turn influences key ecosystem processes including productivity, evapotranspiration and habitat availability. In tropical forests increasingly modified by human activities, the interplay between environmental factors and disturbance legacies on forest canopy structure across landscapes is practically unexplored. We used airborne laser scanning (ALS) data to measure the canopy of old-growth and selectively logged peat swamp forest across a peat dome in Central Kalimantan, Indonesia, and quantified how canopy structure metrics varied with peat depth and under logging. Several million canopy gaps in different height cross-sections of the canopy were measured in 100 plots of 1 km2 spanning the peat dome, allowing us to describe canopy structure with seven metrics. Old-growth forest became shorter and had simpler vertical canopy profiles on deeper peat, consistent with previous work linking deep peat to stunted tree growth. Gap size frequency distributions (GSFDs) indicated fewer and smaller canopy gaps on the deeper peat (i.e. the scaling exponent of Pareto functions increased from 1.76 to 3.76 with peat depth). Areas subjected to concessionary logging until 2000, and illegal logging since then, had the same canopy top height as old-growth forest, indicating the persistence of some large trees, but mean canopy height was significantly reduced. With logging, the total area of canopy gaps increased and the GSFD scaling exponent was reduced. Logging effects were most evident on the deepest peat, where nutrient depletion and waterlogged conditions restrain tree growth and recovery. A tight relationship exists between canopy structure and peat depth gradient within the old-growth tropical peat swamp forest. This relationship breaks down after selective logging, with canopy structural recovery, as observed by ALS, modulated by environmental conditions. These findings improve our

  11. Geophysical borehole logging in the unsaturated zone, Yucca Mountain, Nevada

    USGS Publications Warehouse

    Schimschal, Ulrich; Nelson, Philip H.

    1991-01-01

    Borehole geophysical logging for site characterization in the volcanic rocks at the proposed nuclear waste repository at Yucca Mountain, Nevada, requires data collection under rather unusual conditions. Logging tools must operate in rugose, dry holes above the water table in the unsaturated zone. Not all logging tools will operate in this environment, therefore; careful consideration must be given to selection and calibration. A sample suite of logs is presented that demonstrates correlation of geological formations from borehole to borehole, the definition of zones of altered mineralogy, and the quantitative estimates of rock properties. We show the results of an exploratory calculation of porosity and water saturation based upon density and epithermal neutron logs. Comparison of the results with a few core samples is encouraging, particularly because the logs can provide continuous data in boreholes where core samples are not available.

  12. Color images of Kansas subsurface geology from well logs

    USGS Publications Warehouse

    Collins, D.R.; Doveton, J.H.

    1986-01-01

    Modern wireline log combinations give highly diagnostic information that goes beyond the basic shale content, pore volume, and fluid saturation of older logs. Pattern recognition of geology from logs is made conventionally through either the examination of log overlays or log crossplots. Both methods can be combined through the use of color as a medium of information by setting the three color primaries of blue, green, and red light as axes of three dimensional color space. Multiple log readings of zones are rendered as composite color mixtures which, when plotted sequentially with depth, show lithological successions in a striking manner. The method is extremely simple to program and display on a color monitor. Illustrative examples are described from the Kansas subsurface. ?? 1986.

  13. Log evaluation of oil-bearing igneous rocks

    SciTech Connect

    Khatchikian, A.

    1983-12-01

    The evaluation of porosity, water saturation and clay content of oilbearing igneous rocks with well logs is difficult due to the mineralogical complexity of this type of rocks. The log responses to rhyolite and rhyolite tuff; andesite, dacite and zeolite tuff; diabase and basalt have been studied from examples in western Argentina and compared with values observed in other countries. Several field examples show how these log responses can be used in a complex lithology program to make a complete evaluation.

  14. Western tight gas sands advanced logging workshop proceedings

    SciTech Connect

    Jennings, J B; Carroll, Jr, H B

    1982-04-01

    An advanced logging research program is one major aspect of the Western Tight Sands Program. Purpose of this workshop is to help BETC define critical logging needs for tight gas sands and to allow free interchange of ideas on all aspects of the current logging research program. Sixteen papers and abstracts are included together with discussions. Separate abstracts have been prepared for the 12 papers. (DLC)

  15. A Clustering Methodology of Web Log Data for Learning Management Systems

    ERIC Educational Resources Information Center

    Valsamidis, Stavros; Kontogiannis, Sotirios; Kazanidis, Ioannis; Theodosiou, Theodosios; Karakos, Alexandros

    2012-01-01

    Learning Management Systems (LMS) collect large amounts of data. Data mining techniques can be applied to analyse their web data log files. The instructors may use this data for assessing and measuring their courses. In this respect, we have proposed a methodology for analysing LMS courses and students' activity. This methodology uses a Markov…

  16. Reading Logs: An Application of Reader-Response Theory in ELT.

    ERIC Educational Resources Information Center

    Carlisle, Anthony

    2000-01-01

    Introduces the activity of student-written reading logs as a practical application of reader-response theory in English-as-Foreign-Language literature teaching. Because reader-response theory stresses the synthesis between reader and text, it is proposed that practical applications should be based on the interaction. (Author/VWL)

  17. The effect of hydrophobicity upon the direct mutagenicity of N-acyloxy-N-alkoxyamides--Bilinear dependence upon LogP.

    PubMed

    Glover, Stephen A; Schumacher, Rhiannon R

    2016-01-01

    N-Acyloxy-N-alkoxyamides 1 are direct-acting mutagens for which a bilinear QSAR has been established, which predicts with accuracy their activity in the Ames reverse mutation assay in Salmonella typhimurium TA100, based upon their hydrophobicity (LogP), reactivity (pKA of the carboxylic acid of the N-carboxyl group) and TAFT steric parameters. From activity data for 55 congeners and incorporating five mutagens bearing long-chain hydrocarbons on the alkoxyl and acyloxyl groups, designed for this study, a maximal LogPo, is found to be LogP=6.4. Mutagens with LogPLogP>LogPo undergo lipid entrapment which masks the DNA binding effect. The QSAR has been used to differentiate between lipophilicity and steric inhibition to groove binding in a series of outliers bearing large tert-butyl groups as well as to confirm the enhancement to DNA binding of the naphthalene moiety, which is shown to be equivalent to about 3.5LogP units. PMID:26774666

  18. Allied health applications of a computerized clinical log database system.

    PubMed

    Boyce, K E; Winn, J S; Anderson, S L; Bryant, B G

    1999-01-01

    Preliminary research in the development and use of computerized clinical log records began in 1987 in an allied health college at a midwestern academic health center. This article reviews development and implementation of a computerized system for managing clinical log records to improve and enhance allied health educational programs in the radiation sciences. These clinical log databases are used for quantitative and qualitative analyses of student participation in clinical procedures, and educational planning for each student. Collecting and recording data from clinical log records serves as a valuable instructional tool for students, with both clinical and didactic applications. PMID:10389054

  19. Effects of postfire salvage logging on deadwood-associated beetles.

    PubMed

    Cobb, T P; Morissette, J L; Jacobs, J M; Koivula, M J; Spence, J R; Langor, D W

    2011-02-01

    In Canada and the United States pressure to recoup financial costs of wildfire by harvesting burned timber is increasing, despite insufficient understanding of the ecological consequences of postfire salvage logging. We compared the species richness and composition of deadwood-associated beetle assemblages among undisturbed, recently burned, logged, and salvage-logged, boreal, mixed-wood stands. Species richness was lowest in salvage-logged stands, largely due to a negative effect of harvesting on the occurrence of wood- and bark-boring species. In comparison with undisturbed stands, the combination of wildfire and logging in salvage-logged stands had a greater effect on species composition than either disturbance alone. Strong differences in species composition among stand treatments were linked to differences in quantity and quality (e.g., decay stage) of coarse woody debris. We found that the effects of wildfire and logging on deadwood-associated beetles were synergistic, such that the effects of postfire salvage logging could not be predicted reliably on the basis of data on either disturbance alone. Thus, increases in salvage logging of burned forests may have serious negative consequences for deadwood-associated beetles and their ecological functions in early postfire successional forests. PMID:20735453

  20. 7. William E. Barrett, Photographer, August 1975. LOG PONDS LOOKING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. William E. Barrett, Photographer, August 1975. LOG PONDS LOOKING WEST FROM POWERHOUSE ROOF. TRANSFORMER SHED IN FOREGROUND. - Meadow River Lumber Company, Highway 60, Rainelle, Greenbrier County, WV

  1. Using a Log Analyser to Assist Research into Haptic Technology

    NASA Astrophysics Data System (ADS)

    Jónsson, Fannar Freyr; Hvannberg, Ebba Þóra

    Usability evaluations collect subjective and objective measures. Examples of the latter are time to complete a task. The paper describes use cases of a log analyser for haptic feedback. The log analyser reads a log file and extracts information such as time of each practice and assessment session, analyses whether the user goes off curve and measures the force applied. A study case using the analyser is performed using a PHANToM haptic learning environment application that is used to teach young visually impaired students the subject of polynomials. The paper answers six questions to illustrate further use cases of the log analyser.

  2. Saving big bucks with your log sheets

    SciTech Connect

    Puskar, J.R.

    1999-07-01

    This article speaks to a common problem in a lot of industrial and institutional boilerhouses. Most boilerhouses do an excellent job at collecting information. Circular chart recorders churn out pressures, temperatures, and flows for everything from steam to natural gas to city water consumption. At most facilities, this stuff all gets chucked into a drawer or file cabinet daily. Have you ever wondered why you collect and record what you do? What were people thinking when the existing logs were set up? This article attempts to challenge the original thought process and hopes to evoke in the reader a renewed vision of what should be collected, how, and then what can be done with it. The goal of this article is not to define new and expensive data acquisition or control system projects. It is instead to show how to develop systems that only require paper, pencils, and people who are motivated and care. These people are probably already being paid to do most of this work. Experience is that if these people are treated with respect and given some simple tools they will do amazing things beyond what was thought possible. This is a low-tech humanistic approach that has a fabulous rate of return. It`s also something that can be immediately implemented.

  3. log(MPl/m3/2)

    SciTech Connect

    Loaiza-Brito, Oscar; Martin, Johannes; Nilles, Hans Peter; Ratz, Michael

    2005-12-02

    Flux compactifications of string theory seem to require the presence of a fine-tuned constant in the superpotential. We discuss a scheme where this constant is replaced by a dynamical quantity which we argue to be a 'continuous Chern-Simons term'. In such a scheme, the gaugino condensate generates the hierarchically small scale of supersymmetry breakdown rather than adjusting its size to a constant. A crucial ingredient is the appearance of the hierarchically small quantity exp(-) which corresponds to the scale of gaugino condensation. Under rather general circumstances, this leads to a scenario of moduli stabilization, which is endowed with a hierarchy between the mass of the lightest modulus, the gravitino mass and the scale of the soft terms, mmodulus {approx} m3/2 {approx} 2 msoft. The 'little hierarchy' is given by the logarithm of the ratio of the Planck scale and the gravitino mass, {approx} log(MPl/m3/2) {approx} 4{pi}2. This exhibits a new mediation scheme of supersymmetry breakdown, called mirage mediation. We highlight the special properties of the scheme, and their consequences for phenomenology and cosmology.

  4. MCNP capabilities for nuclear well logging calculations

    SciTech Connect

    Forster, R.A.; Little, R.C.; Briesmeister, J.F.; Hendricks, J.S. . Applied Theoretical Physics Div.)

    1990-06-01

    The Los Alamos Radiation Transport Code System (LARTCS) consists of state-of-the-art Monte Carlo and discrete ordinates transport codes and data libraries. This paper discusses how the general-purpose continuous-energy Monte Carlo code MCNP ({und M}onte {und C}arlo {und n}eutron {und p}hoton), part of the LARTCS, provides a computational predictive capability for many applications of interest to the nuclear well logging community. The generalized three-dimensional geometry of MCNP is well suited for borehole-tool models. SABRINA, another component of the LARTCS, is a graphics code that can be used to interactively create a complex MCNP geometry. Users can define many source and tally characteristics with standard MCNP features. The time-dependent capability of the code is essential when modeling pulsed sources. Problems with neutrons, photons, and electrons as either single particle or coupled particles can be calculated with MCNP. The physics of neutron and photon transport and interactions is modeled in detail using the latest available cross-section data.

  5. Borehole induction logging for the Dynamic Underground Stripping Project LLNL gasoline spill site

    SciTech Connect

    Boyd, S.; Newmark, R.; Wilt, M.

    1994-01-21

    Borehole induction logs were acquired for the purpose of characterizing subsurface physical properties and monitoring steam clean up activities at the Lawrence Livermore National Laboratory. This work was part of the Dynamic Underground Stripping Project`s demonstrated clean up of a gasoline spin. The site is composed of unconsolidated days, sands and gravels which contain gasoline both above and below the water table. Induction logs were used to characterize lithology, to provide ``ground truth`` resistivity values for electrical resistance tomography (ERT), and to monitor the movement of an underground steam plume used to heat the soil and drive volatile organic compounds (VOCs) to the extraction wells.

  6. The Flux of Carbon from Selective Logging, Fire, and Regrowth in Amazonia

    NASA Technical Reports Server (NTRS)

    Houghton, R. A.

    2004-01-01

    The major goal of this work was to develop a spatial, process-based model (CARLUC) that would calculate sources and sinks of carbon from changes in land use, including logging and fire. The work also included Landsat data, together with fieldwork, to investigate fire and logging in three different forest types within Brazilian Amazonia. Results from these three activities (modeling, fieldwork, and remote sensing) are described, individually, below. The work and some of the personnel overlapped with research carried out by Dr. Daniel Nepstad's LBA team, and thus some of the findings are also reported in his summaries.

  7. An Examination of Forest Certification Status among Logging Companies in Cameroon.

    PubMed

    Nukpezah, Daniel; Alemagi, Dieudonne; Duguma, Lalisa; Minang, Peter; Mbosso, Charlie; Tchoundjeu, Zac

    2014-01-01

    This paper assesses the level of interest, awareness, and adoption of ISO 14001 and Forest Stewardship Council (FSC) certification schemes among logging companies in Cameroon. Eleven logging companies located in Douala in the Littoral Region of Cameroon were assessed through a structured interview using an administered questionnaire which was mostly analyzed qualitatively thereafter. The findings indicated that none of the companies was certified for ISO 14001; however 63.64% of them were already FSC-certified. Four companies (36.36%) were neither FSC- nor ISO 14001 EMS-certified. Among the factors found to influence the adoption rate was the level of awareness about ISO 14001 and FSC certification schemes. The main drivers for pursuing FSC certification were easy penetration into international markets, tax holiday benefits, and enhancement of corporate image of the logging companies through corporate social responsibility fulfillments. Poor domestic market for certified products was found to be the major impediment to get certified. To make logging activities more environmentally friendly and socially acceptable, logging companies should be encouraged to get certified through the ISO 14001 EMS scheme which is almost nonexistent so far. This requires awareness creation about the scheme, encouraging domestic markets for certified products and creating policy incentives. PMID:27355041

  8. An Examination of Forest Certification Status among Logging Companies in Cameroon

    PubMed Central

    Nukpezah, Daniel; Alemagi, Dieudonne; Duguma, Lalisa; Minang, Peter; Mbosso, Charlie; Tchoundjeu, Zac

    2014-01-01

    This paper assesses the level of interest, awareness, and adoption of ISO 14001 and Forest Stewardship Council (FSC) certification schemes among logging companies in Cameroon. Eleven logging companies located in Douala in the Littoral Region of Cameroon were assessed through a structured interview using an administered questionnaire which was mostly analyzed qualitatively thereafter. The findings indicated that none of the companies was certified for ISO 14001; however 63.64% of them were already FSC-certified. Four companies (36.36%) were neither FSC- nor ISO 14001 EMS-certified. Among the factors found to influence the adoption rate was the level of awareness about ISO 14001 and FSC certification schemes. The main drivers for pursuing FSC certification were easy penetration into international markets, tax holiday benefits, and enhancement of corporate image of the logging companies through corporate social responsibility fulfillments. Poor domestic market for certified products was found to be the major impediment to get certified. To make logging activities more environmentally friendly and socially acceptable, logging companies should be encouraged to get certified through the ISO 14001 EMS scheme which is almost nonexistent so far. This requires awareness creation about the scheme, encouraging domestic markets for certified products and creating policy incentives. PMID:27355041

  9. Little effects of reduced-impact logging on insect communities in eastern Amazonia.

    PubMed

    Nogueira, Denis Silva; Calvão, Lenize Batista; de Assis Montag, Luciano Fogaça; Juen, Leandro; De Marco, Paulo

    2016-07-01

    Selective logging has become a major source of threats to tropical forest, bringing challenges for both ecologists and managers to develop low-impact forestry. Reduced-impact logging (RIL) is a prominent activity accounting for such forestry practices to prevent strong forest disturbances. Our aims were to evaluate the effects of RIL on insect communities of forested streams from Eastern Amazon and to test the hypothesis of negative effects of RIL on species richness, abundance, and functional feeding groups of aquatic insect assemblages. Neither of the evaluated metrics of the studied assemblages were negatively affected by RIL. Environmental metrics, such as substrate heterogeneity, woody canopy cover, and hill slope height, varied more among RIL streams than in reference streams, indicating a gradient according to logging impacts, and are suitable candidates to monitor RIL impacts in Amazonian streams. In addition, the PHI index also varied among REF and RIL, according to age class and year of logging, which could reflect trends to recover the forest structure after logging in a time frame of only 10 years. We conclude that RIL impacts have not had detrimental impacts on insect communities, but have changed little of the environmental conditions, especially of the riparian vegetation around streams. PMID:27353133

  10. High flare activity and redistribution of solar global magnetic fields

    NASA Astrophysics Data System (ADS)

    Bumba, V.; Hejna, L.; Gesztelyi, L.

    It is demonstrated that, both on the global scale and on the scale of large and complex active regions, high flare activity is closely related to changes in the whole background magnetic-field distribution. It is found that the disturbances of the normal course of magnetic active longitudes (MAL) during the years 1965-1980 correlated with the maxima of flare activity, while the mode of the MAL distribution correlated with the mean level of solar flare numbers. The development of activity during the last two submaxima of the 21st cycle, especially the formation of the white-light flare region of April 1984, were parts of global processes in the solar atmosphere. They were accompanied by a complete reorganization of the MAL patterns, background field sector structure, and coronal holes.

  11. Readaptation of the Vestibulo-Ocular Reflex Relieves the Mal De Debarquement Syndrome

    PubMed Central

    Dai, Mingjia; Cohen, Bernard; Smouha, Eric; Cho, Catherine

    2014-01-01

    The mal de debarquement syndrome (MdDS), a continuous feeling of swaying, rocking, and/or bobbing, generally follows travel on the sea. The associated symptoms cause considerable distress. The underlying neural mechanisms are unknown, and to date there have been no effective treatments for this condition. Results in monkeys and humans suggested that MdDS was caused by maladaptation of the vestibulo-ocular reflex (VOR) to roll of the head during rotation. We studied 24 subjects with persistent MdDS (3 males, 21 females; 19.1 ± 33 months). Physical findings included body oscillation at 0.2 Hz, oscillating vertical nystagmus when the head was rolled from side-to-side in darkness, and unilateral rotation during the Fukuda stepping test. We posited that the maladapted rocking and the physical symptoms could be diminished or extinguished by readapting the VOR. Subjects were treated by rolling the head from side-to-side while watching a rotating full-field visual stimulus. Seventeen of the 24 subjects had a complete or substantial recovery on average for approximately 1 year. Six were initially better, but the symptoms recurred. One subject did not respond to treatment. Thus, readaptation of the VOR has led to a cure or substantial improvement in 70% of the subjects with MdDS. We conclude that the adaptive processes associated with roll-while-rotating are responsible for producing MdDS, and that the symptoms can be reduced or resolved by readapting the VOR. PMID:25076935

  12. Early interruption of exclusive breastfeeding: results from the eight-country MAL-ED study.

    PubMed

    Patil, Crystal L; Turab, Ali; Ambikapathi, Ramya; Nesamvuni, Cebisa; Chandyo, Ram Krishna; Bose, Anuradha; Islam, M Munirul; Ahmed, A M Shamsir; Olortegui, Maribel Paredes; de Moraes, Milena Lima; Caulfield, Laura E

    2015-01-01

    We report the infant feeding experiences in the first month of life for 2,053 infants participating in "Malnutrition and Enteric Infections: Consequences for Child Health and Development" (MAL-ED). Eight sites (in Bangladesh, India, Nepal, Pakistan, Brazil, Peru, South Africa, Tanzania), each followed a cohort of children from birth (by day 17), collecting detailed information on infant feeding practices, diet and illness episodes. Mothers were queried twice weekly regarding health status, breastfeeding and the introduction (or no) of non-breast milk liquids and foods. Here, our goal is to describe the early infant feeding practices in the cohort and evaluate factors associated with termination of exclusive breastfeeding in the first month of life. With data from enrollment to a visit at 28-33 days of life, we characterized exclusive, predominant or partial breastfeeding (using a median of 6-9 visits per child across the sites). Only 6 of 2,053 infants were never breastfed. By one month, the prevalences of exclusive breastfeeding were < 60% in 6 of 8 sites, and of partial breastfeeding (or no) were > 20% in 6 of 8 sites. Logistic regression revealed that prelacteal feeding (given to 4-63% of infants) increased the likelihood of partial breastfeeding (Odds Ratio (OR): 1.48 (95% confidence interval (CI): 1.04, 2.10), as did the withholding of colostrum (2-16% of infants) (OR: 1.63:1.01, 2.62), and being a first-time mother (OR: 1.38:1.10, 1.75). Our results reveal diversity across these sites, but an overall trend of early transition away from exclusive breastfeeding in the first month of life. Interventions which introduce or reinforce the WHO/UNICEF Ten Steps for Successful Breastfeeding are needed in these sites to improve breastfeeding initiation, to reinforce exclusive breastfeeding and delay introduction of non-breast milk foods and/or liquids. PMID:26825923

  13. The key role of log jams in the influence of transport and deposition of woody debris in a mountain stream

    NASA Astrophysics Data System (ADS)

    Jochner, Matthias; Turowski, Jens M.; Stoffel, Markus; Badoux, Alexandre

    2014-05-01

    Log jams in mountains streams are preferred storage sites for bedload material and woody debris. The resulting formation of steps and pools within a channel reduces flow velocities and thereby mitigates natural hazards in case of flood events. However, this requires analysing the resilience of log jams during high discharge events which in case of failure can release large amounts of stored material. In this study we investigate log jams in the Erlenbach mountain stream in the Swiss Prealps regarding their storage function of woody debris and residence times of stored logs. Nine log jams were surveyed in detail regarding their position, extent and volume. Artificially introduced wood pieces were tagged with Radio Frequency Identification (RFID) transponders and tracked along a study reach for five months. These tracers confirmed the hypothesis of debris dams being a preferred storage site for dead wood in mountain streams by the calculating tracer data point densities. The average point density for obstruction free channel reaches amounts to 0.13 pieces per m2 while it increases to 0.46 pieces per m2 for channel areas covered by log jams. The size and position of the log jams are mainly determined by bank erosion and hillslope activity as log jams are situated in highly active zones. Large logs of coniferous wood within the jams were dated using tree-ring analysis and their residence times within the channel determined based on the year of tree dieback. The residence times of large logs stored within the jams show a strong connection to the last two exceptional discharge events that occurred at the Erlenbach in 2007 and 2010 (flood events with return times of 50 and 20 years, respectively). The highest number of logs died back in 2007. The year with the second largest number of introduced logs is 2010. The consecutive years after those two high discharge events showed a declining number of trees entering the stream. So both events presumably caused a reactivation

  14. Scientific LogAnalyzer: a web-based tool for analyses of server log files in psychological research.

    PubMed

    Reips, Ulf-Dietrich; Stieger, Stefan

    2004-05-01

    Scientific LogAnalyzer is a platform-independent interactive Web service for the analysis of log files. Scientific LogAnalyzer offers several features not available in other log file analysis tools--for example, organizational criteria and computational algorithms suited to aid behavioral and social scientists. Scientific LogAnalyzer is highly flexible on the input side (unlimited types of log file formats), while strictly keeping a scientific output format. Features include (1) free definition of log file format, (2) searching and marking dependent on any combination of strings (necessary for identifying conditions in experiment data), (3) computation of response times, (4) detection of multiple sessions, (5) speedy analysis of large log files, (6) output in HTML and/or tab-delimited form, suitable for import into statistics software, and (7) a module for analyzing and visualizing drop-out. Several methodological features specifically needed in the analysis of data collected in Internet-based experiments have been implemented in the Web-based tool and are described in this article. A regression analysis with data from 44 log file analyses shows that the size of the log file and the domain name lookup are the two main factors determining the duration of an analysis. It is less than a minute for a standard experimental study with a 2 x 2 design, a dozen Web pages, and 48 participants (ca. 800 lines, including data from drop-outs). The current version of Scientific LogAnalyzer is freely available for small log files. Its Web address is http://genpsylab-logcrunsh.unizh.ch/. PMID:15354696

  15. Parameter estimation and forecasting for multiplicative log-normal cascades

    NASA Astrophysics Data System (ADS)

    Leövey, Andrés E.; Lux, Thomas

    2012-04-01

    We study the well-known multiplicative log-normal cascade process in which the multiplication of Gaussian and log normally distributed random variables yields time series with intermittent bursts of activity. Due to the nonstationarity of this process and the combinatorial nature of such a formalism, its parameters have been estimated mostly by fitting the numerical approximation of the associated non-Gaussian probability density function to empirical data, cf. Castaing [Physica DPDNPDT0167-278910.1016/0167-2789(90)90035-N 46, 177 (1990)]. More recently, alternative estimators based upon various moments have been proposed by Beck [Physica DPDNPDT0167-278910.1016/j.physd.2004.01.020 193, 195 (2004)] and Kiyono [Phys. Rev. EPLEEE81539-375510.1103/PhysRevE.76.041113 76, 041113 (2007)]. In this paper, we pursue this moment-based approach further and develop a more rigorous generalized method of moments (GMM) estimation procedure to cope with the documented difficulties of previous methodologies. We show that even under uncertainty about the actual number of cascade steps, our methodology yields very reliable results for the estimated intermittency parameter. Employing the Levinson-Durbin algorithm for best linear forecasts, we also show that estimated parameters can be used for forecasting the evolution of the turbulent flow. We compare forecasting results from the GMM and Kiyono 's procedure via Monte Carlo simulations. We finally test the applicability of our approach by estimating the intermittency parameter and forecasting of volatility for a sample of financial data from stock and foreign exchange markets.

  16. Well Logging and Logging Analysis of UHP metamorphic Rocks in CCSD Main Hole (0-2000m)

    NASA Astrophysics Data System (ADS)

    Pan, H.; Niu, Y.; Wang, W.; Zhu, L.; Xu, D.; Wu, H.; Li, S.; Luo, M.

    2004-12-01

    CCSD logging engineering gather many modern high technologies and employs various advanced logging tools to survey the sidewall continuously. This can obtain various physical, chemical, geometrical, etc in-situ information of the borehole's profile. So well logging is one of the most important parts and pivotal technologies in the project of CCSD. The main logging methods in CCSD-MH(0-2000m) are laterolog (Rd,Rs), gamma ray(GR), nature gamma spectrometry(U, TH, K), density(DEN), photo electric section exponent (Pe), compensated neutron(CNL), multipole array acoustic (Vp, Vs, Vst), Simultaneous Acoustic-Resistivity-image(Star-II), temperature(T),magnetic susceptibility(MS), three component borehole magnetic and redox potential log,etc. The various metamorphic rocks can be classified by logging curves,and their physical parameters can be acquired by analyzing the response characters of various metamorphic rocks and by statistics. According to the logging cross plot, We can research the clustering of metamorphite's physical property. Five lithologic segments can be obtainend by logging curves. The GR, Th, U, K logging values of segment 1 is lower than the third, fourth and fiveth segment, higher than segment 2; The DEN, Pe values of segment 1 higher than the third, fourth and fiveth segments. The main rocks in segment 1,2,3,4,5 are eclogites, serpentinites, paragneiss, orthogneiss, and eclogites(containing silicon and muscovite ) respectively. Generally, eclogite contain rutile, silicon, muscovite, etc. minerals. These minerals have response obviously on log curves.There are rutile,ilmenite, pyrite mineralized, etc. Making use of DEN, Pe, susceptibility log values, these mineralized layers can be goodly demarcation. For example, on the rutile mineralzed layer, the logging curve response characters are of high density and Pe obviously. The key data of the synthetical seismic record is wave impedance. In this paper, Utilize the data of AC, DEN curves to calculate the

  17. An n log n Generalized Born Approximation.

    PubMed

    Anandakrishnan, Ramu; Daga, Mayank; Onufriev, Alexey V

    2011-03-01

    Molecular dynamics (MD) simulations based on the generalized Born (GB) model of implicit solvation offer a number of important advantages over the traditional explicit solvent based simulations. Yet, in MD simulations, the GB model has not been able to reach its full potential partly due to its computational cost, which scales as ∼n(2), where n is the number of solute atoms. We present here an ∼n log n approximation for the generalized Born (GB) implicit solvent model. The approximation is based on the hierarchical charge partitioning (HCP) method (Anandakrishnan and Onufriev J. Comput. Chem. 2010 , 31 , 691 - 706 ) previously developed and tested for electrostatic computations in gas-phase and distant dependent dielectric models. The HCP uses the natural organization of biomolecular structures to partition the structures into multiple hierarchical levels of components. The charge distribution for each of these components is approximated by a much smaller number of charges. The approximate charges are then used for computing electrostatic interactions with distant components, while the full set of atomic charges are used for nearby components. To apply the HCP concept to the GB model, we define the equivalent of the effective Born radius for components. The component effective Born radius is then used in GB computations for points that are distant from the component. This HCP approximation for GB (HCP-GB) is implemented in the open source MD software, NAB in AmberTools, and tested on a set of representative biomolecular structures ranging in size from 632 atoms to ∼3 million atoms. For this set of test structures, the HCP-GB method is 1.1-390 times faster than the GB computation without additional approximations (the reference GB computation), depending on the size of the structure. Similar to the spherical cutoff method with GB (cutoff-GB), which also scales as ∼n log n, the HCP-GB is relatively simple. However, for the structures considered here, we show

  18. Spatiotemporal dynamics of forest degradation by selective logging and forest fire in the Brazilian Amazon

    NASA Astrophysics Data System (ADS)

    Matricardi, Eraldo A. T.

    Selective logging and forest fires have increased at a rapid pace in tropical regions in recent decades. Forest disturbances caused by selective logging and forest fires may vary in scale, ranging from local damage to forest canopy, habitats, soils, and biodiversity, to global changes caused by logging-related release of carbon into the atmosphere. This study provides a regional assessment of forest impacts by selective logging and forest fires for 1992, 1996, and 1999. Multivariate statistical models, remote sensing approaches, Geographic Information System (GIS), and remotely sensed imagery combined with field data were applied to verify the scale of environmental changes associated with these processes of forest disturbance. In this regard, the study widens the current knowledge on land use and land cover classifications to include selectively logged and burned forests as additional thematic classes. These classes have not yet been properly accounted for by conventional remote sensing approaches of deforestation assessment, despite their relevance for the understanding of the changes affecting tropical forests. This study is the first multi-temporal and spatial assessment of the selective logging and forest fire impacts in the Brazilian Amazon. The resulting estimates show that at least 11800 km 2, 16500 km2, and 35600 km2 of natural forests were selectively logged and/or burned by 1992, 1996, and 1999, respectively. More than 60% of these forest disturbances observed in the Brazilian Amazon during those years were due to selective logging activities. However, forest fires were responsible for the greatest impacts on natural forests, causing an estimated loss of 18.8% of forest canopy in the study region. I also estimated that approximately 5467 km2, 7618 km2, and 17437 km2 were active areas of selective logging and/or forest fires in 1992, 1996, and 1999, respectively. In addition, approximately 4% of total forest disturbed by selective logging and forest fires

  19. Idaho National Laboratory PCB Annual Document Log and Annual Records Report for calendar year 2014

    SciTech Connect

    Layton, Deborah L.

    2015-06-01

    The requirements for the reporting of polychlorinated biphenyl (PCB)-related activities are found in 40 Code of Federal Regulations (CFR) 761 Subpart J, "General Records and Reports." The PCB Annual Document Log is a detailed record of the PCB waste handling activities at the facility. The facility must prepare it each year by July 1 and maintain it at the facility for at least 3 years after the facility ceases using or storing PCBs and PCB items. While submittal of the PCB Annual Document Log to the U.S. Environmental Protection Agency (EPA) is not required by regulation, EPA has verbally requested in telephone conversations that this report be submitted to them on an annual basis. The Annual Records are not required to be submitted to EPA and are not considered to be part of the Annual Document Log, but are included to provide the complete disposition history or status of all PCB activities during the year. The Annual Document Log section of this report (Section 2.0) meets the requirements of 40 CFR 761.180(a)(2), as applicable, while the Annual Records section (Section 3.0) meets the requirement of 40 CFR 761.180(a)(1).

  20. Reorganization of the actin cytoskeleton via transcriptional regulation of cytoskeletal/focal adhesion genes by myocardin-related transcription factors (MRTFs/MAL/MKLs)

    SciTech Connect

    Morita, Tsuyoshi; Mayanagi, Taira; Sobue, Kenji

    2007-10-01

    RhoA is a crucial regulator of stress fiber and focal adhesion formation through the activation of actin nucleation and polymerization. It also regulates the nuclear translocation of myocardin-related transcription factor-A and -B (MRTF-A/B, MAL or MKL 1/2), which are co-activators of serum response factor (SRF). In dominant-negative MRTF-A (DN-MRTF-A)-expressing NIH 3T3 cell lines, the expressions of several cytoskeletal/focal adhesion genes were down-regulated, and the formation of stress fiber and focal adhesion was severely diminished. MRTF-A/B-knockdown cells also exhibited such cytoskeletal defects. In reporter assays, both RhoA and MRTF-A enhanced promoter activities of these genes in a CArG-box-dependent manner, and DN-MRTF-A inhibited the RhoA-mediated activation of these promoters. In dominant-negative RhoA (RhoA-N19)-expressing NIH 3T3 cell lines, the nuclear translocation of MRTF-A/B was predominantly prevented, resulting in the reduced expression of cytoskeletal/focal adhesion proteins. Further, constitutive-active MRTF-A/B increased the expression of endogenous cytoskeletal/focal adhesion proteins, and thereby rescued the defective phenotype of stress fibers and focal adhesions in RhoA-N19 expressing cells. These results indicate that MRTF-A/B act as pivotal mediators of stress fiber and focal adhesion formation via the transcriptional regulation of a subset of cytoskeletal/focal adhesion genes.

  1. 33 CFR 207.370 - Big Fork River, Minn.; logging.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false Big Fork River, Minn.; logging..., DEPARTMENT OF DEFENSE NAVIGATION REGULATIONS § 207.370 Big Fork River, Minn.; logging. (a) During the season... maintained at all times for the navigation of steamboats, flatboats, and other small craft. (b) A...

  2. 33 CFR 207.370 - Big Fork River, Minn.; logging.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 3 2012-07-01 2012-07-01 false Big Fork River, Minn.; logging..., DEPARTMENT OF DEFENSE NAVIGATION REGULATIONS § 207.370 Big Fork River, Minn.; logging. (a) During the season... maintained at all times for the navigation of steamboats, flatboats, and other small craft. (b) A...

  3. 33 CFR 207.370 - Big Fork River, Minn.; logging.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 3 2014-07-01 2014-07-01 false Big Fork River, Minn.; logging..., DEPARTMENT OF DEFENSE NAVIGATION REGULATIONS § 207.370 Big Fork River, Minn.; logging. (a) During the season... maintained at all times for the navigation of steamboats, flatboats, and other small craft. (b) A...

  4. 33 CFR 207.370 - Big Fork River, Minn.; logging.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Big Fork River, Minn.; logging..., DEPARTMENT OF DEFENSE NAVIGATION REGULATIONS § 207.370 Big Fork River, Minn.; logging. (a) During the season... maintained at all times for the navigation of steamboats, flatboats, and other small craft. (b) A...

  5. 33 CFR 207.370 - Big Fork River, Minn.; logging.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 3 2013-07-01 2013-07-01 false Big Fork River, Minn.; logging..., DEPARTMENT OF DEFENSE NAVIGATION REGULATIONS § 207.370 Big Fork River, Minn.; logging. (a) During the season... maintained at all times for the navigation of steamboats, flatboats, and other small craft. (b) A...

  6. Prediction of Log "P": ALOGPS Application in Medicinal Chemistry Education

    ERIC Educational Resources Information Center

    Kujawski, Jacek; Bernard, Marek K.; Janusz, Anna; Kuzma, Weronika

    2012-01-01

    Molecular hydrophobicity (lipophilicity), usually quantified as log "P" where "P" is the partition coefficient, is an important molecular characteristic in medicinal chemistry and drug design. The log "P" coefficient is one of the principal parameters for the estimation of lipophilicity of chemical compounds and pharmacokinetic properties. The…

  7. Design and Use of the Stratigraphic Strip Log.

    ERIC Educational Resources Information Center

    Fichter, Lynn Stanton

    1987-01-01

    Discusses the use of a strip log as a diagrammatic representation of the information available in a sequence of sedimentary rocks. Describes the design of the strip log (both symbolically and by visual/spatial patterns) and some of the possible interpretations that can be made using them. (TW)

  8. Teaching an Old Log New Tricks with Machine Learning.

    PubMed

    Schnell, Krista; Puri, Colin; Mahler, Paul; Dukatz, Carl

    2014-03-01

    To most people, the log file would not be considered an exciting area in technology today. However, these relatively benign, slowly growing data sources can drive large business transformations when combined with modern-day analytics. Accenture Technology Labs has built a new framework that helps to expand existing vendor solutions to create new methods of gaining insights from these benevolent information springs. This framework provides a systematic and effective machine-learning mechanism to understand, analyze, and visualize heterogeneous log files. These techniques enable an automated approach to analyzing log content in real time, learning relevant behaviors, and creating actionable insights applicable in traditionally reactive situations. Using this approach, companies can now tap into a wealth of knowledge residing in log file data that is currently being collected but underutilized because of its overwhelming variety and volume. By using log files as an important data input into the larger enterprise data supply chain, businesses have the opportunity to enhance their current operational log management solution and generate entirely new business insights-no longer limited to the realm of reactive IT management, but extending from proactive product improvement to defense from attacks. As we will discuss, this solution has immediate relevance in the telecommunications and security industries. However, the most forward-looking companies can take it even further. How? By thinking beyond the log file and applying the same machine-learning framework to other log file use cases (including logistics, social media, and consumer behavior) and any other transactional data source. PMID:27447306

  9. 46 CFR 148.100 - Log book entries.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 5 2013-10-01 2013-10-01 false Log book entries. 148.100 Section 148.100 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) DANGEROUS CARGOES CARRIAGE OF BULK SOLID MATERIALS THAT REQUIRE SPECIAL HANDLING Minimum Transportation Requirements § 148.100 Log book entries....

  10. 46 CFR 148.100 - Log book entries.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 5 2011-10-01 2011-10-01 false Log book entries. 148.100 Section 148.100 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) DANGEROUS CARGOES CARRIAGE OF BULK SOLID MATERIALS THAT REQUIRE SPECIAL HANDLING Minimum Transportation Requirements § 148.100 Log book entries....

  11. 46 CFR 148.100 - Log book entries.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 5 2012-10-01 2012-10-01 false Log book entries. 148.100 Section 148.100 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) DANGEROUS CARGOES CARRIAGE OF BULK SOLID MATERIALS THAT REQUIRE SPECIAL HANDLING Minimum Transportation Requirements § 148.100 Log book entries....

  12. 46 CFR 148.100 - Log book entries.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 5 2014-10-01 2014-10-01 false Log book entries. 148.100 Section 148.100 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) DANGEROUS CARGOES CARRIAGE OF BULK SOLID MATERIALS THAT REQUIRE SPECIAL HANDLING Minimum Transportation Requirements § 148.100 Log book entries....

  13. Condition and fate of logged forests in the Brazilian Amazon

    PubMed Central

    Asner, Gregory P.; Broadbent, Eben N.; Oliveira, Paulo J. C.; Keller, Michael; Knapp, David E.; Silva, José N. M.

    2006-01-01

    The long-term viability of a forest industry in the Amazon region of Brazil depends on the maintenance of adequate timber volume and growth in healthy forests. Using extensive high-resolution satellite analyses, we studied the forest damage caused by recent logging operations and the likelihood that logged forests would be cleared within 4 years after timber harvest. Across 2,030,637 km2 of the Brazilian Amazon from 1999 to 2004, at least 76% of all harvest practices resulted in high levels of canopy damage sufficient to leave forests susceptible to drought and fire. We found that 16 ± 1% of selectively logged areas were deforested within 1 year of logging, with a subsequent annual deforestation rate of 5.4% for 4 years after timber harvests. Nearly all logging occurred within 25 km of main roads, and within that area, the probability of deforestation for a logged forest was up to four times greater than for unlogged forests. In combination, our results show that logging in the Brazilian Amazon is dominated by highly damaging operations, often followed rapidly by deforestation decades before forests can recover sufficiently to produce timber for a second harvest. Under the management regimes in effect at the time of our study in the Brazilian Amazon, selective logging would not be sustained. PMID:16901980

  14. Data-Logging in Practical Science: Research and Reality.

    ERIC Educational Resources Information Center

    Newton, Leonard R.

    2000-01-01

    Surveys some of the benefits claimed for data-logging methods identified through research. Discusses findings from research that sought to explore the translation of these benefits into the real-world of science classrooms and identify the range of influences on science teachers adopting and developing data-logging methods. (SAH)

  15. 29 CFR 1401.32 - Logging of written requests.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 4 2011-07-01 2011-07-01 false Logging of written requests. 1401.32 Section 1401.32 Labor Regulations Relating to Labor (Continued) FEDERAL MEDIATION AND CONCILIATION SERVICE PUBLIC INFORMATION Production or Disclosure of Information § 1401.32 Logging of written requests. (a) All requests for...

  16. 29 CFR 1401.32 - Logging of written requests.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 4 2013-07-01 2013-07-01 false Logging of written requests. 1401.32 Section 1401.32 Labor Regulations Relating to Labor (Continued) FEDERAL MEDIATION AND CONCILIATION SERVICE PUBLIC INFORMATION Production or Disclosure of Information § 1401.32 Logging of written requests. (a) All requests for...

  17. 29 CFR 1401.32 - Logging of written requests.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 4 2012-07-01 2012-07-01 false Logging of written requests. 1401.32 Section 1401.32 Labor Regulations Relating to Labor (Continued) FEDERAL MEDIATION AND CONCILIATION SERVICE PUBLIC INFORMATION Production or Disclosure of Information § 1401.32 Logging of written requests. (a) All requests for...

  18. 29 CFR 1401.32 - Logging of written requests.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Logging of written requests. 1401.32 Section 1401.32 Labor Regulations Relating to Labor (Continued) FEDERAL MEDIATION AND CONCILIATION SERVICE PUBLIC INFORMATION Production or Disclosure of Information § 1401.32 Logging of written requests. (a) All requests for...

  19. 29 CFR 1401.32 - Logging of written requests.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 4 2014-07-01 2014-07-01 false Logging of written requests. 1401.32 Section 1401.32 Labor Regulations Relating to Labor (Continued) FEDERAL MEDIATION AND CONCILIATION SERVICE PUBLIC INFORMATION Production or Disclosure of Information § 1401.32 Logging of written requests. (a) All requests for...

  20. Condition and fate of logged forests in the Brazilian Amazon.

    PubMed

    Asner, Gregory P; Broadbent, Eben N; Oliveira, Paulo J C; Keller, Michael; Knapp, David E; Silva, José N M

    2006-08-22

    The long-term viability of a forest industry in the Amazon region of Brazil depends on the maintenance of adequate timber volume and growth in healthy forests. Using extensive high-resolution satellite analyses, we studied the forest damage caused by recent logging operations and the likelihood that logged forests would be cleared within 4 years after timber harvest. Across 2,030,637 km2 of the Brazilian Amazon from 1999 to 2004, at least 76% of all harvest practices resulted in high levels of canopy damage sufficient to leave forests susceptible to drought and fire. We found that 16+/-1% of selectively logged areas were deforested within 1 year of logging, with a subsequent annual deforestation rate of 5.4% for 4 years after timber harvests. Nearly all logging occurred within 25 km of main roads, and within that area, the probability of deforestation for a logged forest was up to four times greater than for unlogged forests. In combination, our results show that logging in the Brazilian Amazon is dominated by highly damaging operations, often followed rapidly by deforestation decades before forests can recover sufficiently to produce timber for a second harvest. Under the management regimes in effect at the time of our study in the Brazilian Amazon, selective logging would not be sustained. PMID:16901980

  1. 6. Livestock barn (far left), log drafthorse barn (left of ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Livestock barn (far left), log draft-horse barn (left of center), loafing shed (center), log calving barn (right of center). View to west-northwest. - William & Lucina Bowe Ranch, County Road 44, 0.1 mile northeast of Big Hole River Bridge, Melrose, Silver Bow County, MT

  2. A RAPID METHOD FOR ESTIMATING LOG P FOR ORGANIC CHEMICALS

    EPA Science Inventory

    The logarithm of the retention time (log RT) of organic chemicals on a permanently bonded (C-18) reverse-phase high-pressure liquid chromatography system is shown to be linearly related to the logarithm of the n-octanol/water partition coefficient (log P). A rapid, inexpensive te...

  3. Ubiquitous Learning Project Using Life-Logging Technology in Japan

    ERIC Educational Resources Information Center

    Ogata, Hiroaki; Hou, Bin; Li, Mengmeng; Uosaki, Noriko; Mouri, Kosuke; Liu, Songran

    2014-01-01

    A Ubiquitous Learning Log (ULL) is defined as a digital record of what a learner has learned in daily life using ubiquitous computing technologies. In this paper, a project which developed a system called SCROLL (System for Capturing and Reusing Of Learning Log) is presented. The aim of developing SCROLL is to help learners record, organize,…

  4. A study of sonic logging in a cased borehole

    SciTech Connect

    Chang, S.; Everhart, A.

    1982-09-01

    A study was undertaken to investigate the feasibility of sonic logging in a cased borehole. Results were obtained from a scaled-model laboratory experiment and from computer simulations. The waveforms from the computer model indicate that sonic logging can be successful in bonded and unbonded cased holes. A slowness-time semblance signal processing technique is used to obtain wave velocities from waveforms.

  5. A study of sonic logging in a cased borehole

    SciTech Connect

    Chang, S.K.; Everhart, A.H.

    1983-09-01

    A study was undertaken to investigate the feasibility of sonic logging in a cased borehole. Results were obtained from a scale-model laboratory experiment and from computer simulations. The waveforms from the computer model indicate that sonic logging can be successful in bonded and unbonded cased holes. A slowness/timesemblance signal-processing technique is used to obtain wave velocities from waveforms.

  6. 14 CFR 125.407 - Maintenance log: Airplanes.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Maintenance log: Airplanes. 125.407 Section... OPERATIONS: AIRPLANES HAVING A SEATING CAPACITY OF 20 OR MORE PASSENGERS OR A MAXIMUM PAYLOAD CAPACITY OF 6... Maintenance log: Airplanes. (a) Each person who takes corrective action or defers action concerning a...

  7. 14 CFR 125.407 - Maintenance log: Airplanes.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Maintenance log: Airplanes. 125.407 Section... OPERATIONS: AIRPLANES HAVING A SEATING CAPACITY OF 20 OR MORE PASSENGERS OR A MAXIMUM PAYLOAD CAPACITY OF 6... Maintenance log: Airplanes. (a) Each person who takes corrective action or defers action concerning a...

  8. 14 CFR 125.407 - Maintenance log: Airplanes.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Maintenance log: Airplanes. 125.407 Section... OPERATIONS: AIRPLANES HAVING A SEATING CAPACITY OF 20 OR MORE PASSENGERS OR A MAXIMUM PAYLOAD CAPACITY OF 6... Maintenance log: Airplanes. (a) Each person who takes corrective action or defers action concerning a...

  9. 14 CFR 125.407 - Maintenance log: Airplanes.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Maintenance log: Airplanes. 125.407 Section... OPERATIONS: AIRPLANES HAVING A SEATING CAPACITY OF 20 OR MORE PASSENGERS OR A MAXIMUM PAYLOAD CAPACITY OF 6... Maintenance log: Airplanes. (a) Each person who takes corrective action or defers action concerning a...

  10. Effects of selective logging on tropical forest tree growth

    NASA Astrophysics Data System (ADS)

    Figueira, Adelaine Michela E. S.; Miller, Scott D.; de Sousa, Cleilim Albert D.; Menton, Mary C.; Maia, Augusto R.; Da Rocha, Humberto R.; Goulden, Michael L.

    2008-03-01

    We combined measurements of tree growth and carbon dioxide exchange to investigate the effects of selective logging on the Aboveground Live Biomass (AGLB) of a tropical rain forest in the Amazon. Most of the measurements began at least 10 months before logging and continued at least 36 months after logging. The logging removed ˜15% of the trees with Diameter at Breast Height (DBH) greater than 35 cm, which resulted in an instantaneous 10% reduction in AGLB. Both wood production and mortality increased following logging, while Gross Primary Production (GPP) was unchanged. The ratio of wood production to GPP (the wood Carbon Use Efficiency or wood CUE) more than doubled following logging. Small trees (10 cm < DBH < 35 cm) accounted for most of the enhanced wood production. Medium trees (35 cm < DBH < 55 cm) that were within 30 m of canopy gaps created by the logging also showed increased growth. The patterns of enhanced growth are most consistent with logging-induced increases in light availability. The AGLB continued to decline over the study, as mortality outpaced wood production. Wood CUE and mortality remained elevated throughout the 3 years of postlogging measurements. The future trajectory of AGLB and the forest's carbon balance are uncertain, and will depend on how long it takes for heterotrophic respiration, mortality, and CUE to return to prelogging levels.

  11. VIEW OF DEBARKER FROM LOG INFEED DECK. NOTE ROOF SUPPORT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF DEBARKER FROM LOG IN-FEED DECK. NOTE ROOF SUPPORT OVER CARRIAGE AND LOG IN-FEED DECK IN UPPER RIGHT. (SEE OR-89-18 AND OR-89-23 FOR RELATED ARCHITECTURAL DETAILS.) - Hull-Oakes Lumber Company, 23837 Dawson Road, Monroe, Benton County, OR

  12. 22. VIEW OF DEBARKER FROM LOG INFEED DECK. NOTE ROOF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    22. VIEW OF DEBARKER FROM LOG IN-FEED DECK. NOTE ROOF SUPPORT OVER CARRIAGE AND LOG IN-FEED DECK IN UPPER RIGHT. (SEE OR-89-18 AND OR-89-23 FOR RELATED ARCHITECTURAL DETAILS.) - Hull-Oakes Lumber Company, 23837 Dawson Road, Monroe, Benton County, OR

  13. 47 CFR 80.1153 - Station log and radio watches.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Station log and radio watches. 80.1153 Section 80.1153 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES STATIONS IN THE MARITIME SERVICES Voluntary Radio Installations General § 80.1153 Station log...

  14. 47 CFR 80.1153 - Station log and radio watches.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false Station log and radio watches. 80.1153 Section 80.1153 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES STATIONS IN THE MARITIME SERVICES Voluntary Radio Installations General § 80.1153 Station log...

  15. 47 CFR 80.1153 - Station log and radio watches.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Station log and radio watches. 80.1153 Section 80.1153 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES STATIONS IN THE MARITIME SERVICES Voluntary Radio Installations General § 80.1153 Station log...

  16. 47 CFR 80.1153 - Station log and radio watches.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Station log and radio watches. 80.1153 Section 80.1153 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES STATIONS IN THE MARITIME SERVICES Voluntary Radio Installations General § 80.1153 Station log...

  17. 47 CFR 80.1153 - Station log and radio watches.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 5 2013-10-01 2013-10-01 false Station log and radio watches. 80.1153 Section 80.1153 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES STATIONS IN THE MARITIME SERVICES Voluntary Radio Installations General § 80.1153 Station log...

  18. Real-Time System Log Monitoring/Analytics Framework

    SciTech Connect

    Oral, H Sarp; Dillow, David A; Park, Byung H; Shipman, Galen M; Geist, Al; Gunasekaran, Raghul

    2011-01-01

    Analyzing system logs provides useful insights for identifying system/application anomalies and helps in better usage of system resources. Nevertheless, it is simply not practical to scan through the raw log messages on a regular basis for large-scale systems. First, the sheer volume of unstructured log messages affects the readability, and secondly correlating the log messages to system events is a daunting task. These factors limit large-scale system logs primarily for generating alerts on known system events, and post-mortem diagnosis for identifying previously unknown system events that impacted the systems performance. In this paper, we describe a log monitoring framework that enables prompt analysis of system events in real-time. Our web-based framework provides a summarized view of console, netwatch, consumer, and apsched logs in real- time. The logs are parsed and processed to generate views of applications, message types, individual/group of compute nodes, and in sections of the compute platform. Also from past application runs we build a statistical profile of user/application characteristics with respect to known system events, recoverable/non-recoverable error messages and resources utilized. The web-based tool is being developed for Jaguar XT5 at the Oak Ridge Leadership Computing facility.

  19. 14 CFR 125.407 - Maintenance log: Airplanes.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Maintenance log: Airplanes. 125.407 Section... OPERATIONS: AIRPLANES HAVING A SEATING CAPACITY OF 20 OR MORE PASSENGERS OR A MAXIMUM PAYLOAD CAPACITY OF 6... Maintenance log: Airplanes. (a) Each person who takes corrective action or defers action concerning a...

  20. Web Log Analysis: A Study of Instructor Evaluations Done Online

    ERIC Educational Resources Information Center

    Klassen, Kenneth J.; Smith, Wayne

    2004-01-01

    This paper focuses on developing a relatively simple method for analyzing web-logs. It also explores the challenges and benefits of web-log analysis. The study of student behavior on this site provides insights into website design and the effectiveness of this site in particular. Another benefit realized from the paper is the ease with which these…

  1. West Pembina Nisku reef log-core correlations

    SciTech Connect

    McFadzean, T.B.

    1983-01-01

    A study was initiated to correlate log parameters and core data from West Pembina Nisku (D-2) Pinnacle reefs. The primary objective was to derive basic input data for making volumetric estimates of reserves and for providing initial input data for doing enhanced recovery model studies. A secondary objective was to determine if a set of log analysis parameters could be derived that would work universally in the many pinnacle reefs of the West Pembina area. The results of the study indicate that porosity log response in the West Pembina Nisku reefs deviates a fair amount from the standards used in log analysis chart books. A multilinear regression formula for determining porosity was derived which worked well for 18 wells studied, on which there was both log and core data. A brief description of the Nisku reef geology, a description of the methods used in doing the study, and a graphic presentation of the results are included.

  2. Heimdal monitoring. 1: Establishing feasibility from cores and logs

    SciTech Connect

    Jizba, D.L.; Marion, D.P.

    1994-12-31

    This paper presents a method that uses core and log measurements to quantify the influence of saturation changes on elastic properties at core, log, and seismic scales in order to investigate the feasibility of using seismic measurements to monitor gas production on the Heimdal North Sea field. In the first part, laboratory measurements of P- and S-wave velocities, porosity, density, and mineralogy are used to determined the influence of partial saturation on elastic parameters. These measurement are compared with theoretical predictions using Gassmann`s model. Second, the authors invert from logs, the rock parameters that are necessary to simulate the impact of water rise on elastic properties at log scale. Third, the well logs are modelled at seismic scales of resolution and are used to identify the effect of fluid movement on the seismic response. Finally, the results are compared to repetitive seismic measurements.

  3. Coal log pipeline research at the University of Missouri

    SciTech Connect

    Liu, H.

    1992-03-01

    Project tasks: Perform the necessary testing and development to demonstrate that the amount of binder in coal logs can be reduced to 8% or lower to produce logs with adequate strength to eliminate breakage during pipeline transportation, under conditions experienced in long distance pipeline systems. Prior to conducting any testing and demonstration, grantee shall perform an information search and make full determination of all previous attempts to extrude or briquette coal, upon which the testing and demonstration shall be based. Perform the necessary development to demonstrate a small model of the most promising injection system for coal-logs, and test the logs produced from Task 1. Conduct economic analysis of coal-log pipeline, based upon the work to date. Refine and complete the economic model. Prepare a final report for DOE.

  4. Maintaining ecosystem function and services in logged tropical forests.

    PubMed

    Edwards, David P; Tobias, Joseph A; Sheil, Douglas; Meijaard, Erik; Laurance, William F

    2014-09-01

    Vast expanses of tropical forests worldwide are being impacted by selective logging. We evaluate the environmental impacts of such logging and conclude that natural timber-production forests typically retain most of their biodiversity and associated ecosystem functions, as well as their carbon, climatic, and soil-hydrological ecosystem services. Unfortunately, the value of production forests is often overlooked, leaving them vulnerable to further degradation including post-logging clearing, fires, and hunting. Because logged tropical forests are extensive, functionally diverse, and provide many ecosystem services, efforts to expand their role in conservation strategies are urgently needed. Key priorities include improving harvest practices to reduce negative impacts on ecosystem functions and services, and preventing the rapid conversion and loss of logged forests. PMID:25092495

  5. An {Omega}({radical}log log n) lower bound for routing in optical networks

    SciTech Connect

    Goldberg, L.A.; Jerrum, M.; MacKenzie, P.D.

    1993-11-06

    Optical communication is likely to significantly speed up parallel computation because the vast bandwidth of the optical medium can be divided to produce communication networks of very high degree. However, the problem of contention in high-degree networks makes the routing problem in these networks theoretically (and practically) difficult. In this paper we examine Valiant`s h-relation routing problem, which is a fundamental problem in the theory of parallel computing. The h-relation routing problem arises both in the direct implementation of specific parallel algorithms on distributed-memory machines and in the general simulation of shared memory models such as the PRAM on distributed-memory machines. In an h-relation routing problem each processor has up to h messages that it wishes to send to other processors and each processor is the destination of at most h messages. We present a lower bound for routing an h-relation (for any h > 1) on a complete optical network of size -n. Our lower bound applies to any randomized distributed algorithm for this task. Specifically, we show that the expected number of communication steps required to route an arbitrary h-relation is {Omega}(h + {radical}log log n). This is the first known lower bound for this problem which does not restrict the class of algorithms under consideration.

  6. Landscape-scale changes in forest canopy structure across a partially logged tropical peat swamp

    NASA Astrophysics Data System (ADS)

    Wedeux, B. M. M.; Coomes, D. A.

    2015-07-01

    Forest canopy structure is strongly influenced by environmental factors and disturbance, and in turn influences key ecosystem processes including productivity, evapotranspiration and habitat availability. In tropical forests increasingly modified by human activities, the interplaying effects of environmental factors and disturbance legacies on forest canopy structure across landscapes are practically unexplored. We used high-fidelity airborne laser scanning (ALS) data to measure the canopy of old-growth and selectively logged peat swamp forest across a peat dome in Central Kalimantan, Indonesia, and quantified how canopy structure metrics varied with peat depth and under logging. Several million canopy gaps in different height cross-sections of the canopy were measured in 100 plots of 1 km2 spanning the peat dome, allowing us to describe canopy structure with seven metrics. Old-growth forest became shorter and had simpler vertical canopy profiles on deeper peat, consistently with previous work linking deep peat to stunted tree growth. Gap Size Frequency Distributions (GSFDs) indicated fewer and smaller canopy gaps on the deeper peat (i.e. the scaling exponent of pareto functions increased from 1.76 to 3.76 with peat depth). Areas subjected to concessionary logging until 2000, and informal logging since then, had the same canopy top height as old-growth forest, indicating the persistence of some large trees, but mean canopy height was significantly reduced; the total area of canopy gaps increased and the GSFD scaling exponent was reduced. Logging effects were most evident on the deepest peat, where nutrient depletion and waterlogged conditions restrain tree growth and recovery. A tight relationship exists between canopy structure and the peat deph gradient within the old-growth tropical peat swamp. This relationship breaks down after selective logging, with canopy structural recovery being modulated by environmental conditions.

  7. Assessing the impact of Amazonia logging with a new ecosystem model

    NASA Astrophysics Data System (ADS)

    Huang, M.; Asner, G. P.; Keller, M.; Berry, J. A.; Bustamante, M. M.

    2006-12-01

    Old-growth Amazonian forests play a fundamental role in the global climate and carbon cycle. Land use in old- growth tropical forests contributes to the accumulation of CO2 in the atmosphere and can alter the hydrological cycle, locally, regionally, and globally. Although deforestation, largely for the conversion of land to food crops or pastures, is the major destructive force in tropical forests worldwide (Houghton et al., 2000), other forest disturbances such as the selective logging have also increased in frequency and extent. Selective logging causes widespread collateral damage to remaining trees, sub-canopy vegetation, and soils, with impacts on hydrological processes, erosion, fire, carbon storage, and plant and animal species. In this study, the impact of selective logging on the carbon budget of the Brazil Amazon region is assessed with a new 3-D version of the Carnegie-Ames-Stanford Approach (CASA) ecosystem model, which features: (1) an alternative way of estimating absorbed photosynthetically-active radiation (APAR) by taking advantage of new high-resolution maps of forest canopy gap fraction; (2) a pulse disturbance module to realistically modify the carbon pools after timber harvest; (3) a regrowth module considering changes in community composition; and (4) a radiative transfer module for charactering the dynamic 3-D light environment above the canopy and within gaps after logging. The model was calibrated and validated with field observations from the Large-scale Biosphere Atmosphere Experiment (LBA) and its sensitivity was evaluated with Monte Carlo simulations. The impacts of selected logging on regional carbon budget of the Brazilian Amazon were then assessed under different future climate change scenarios. Results from this study quantify the gross and net carbon storage effects of widespread logging practices throughout the Brazilian Amazon.

  8. Long-term carbon loss and recovery following selective logging in Amazon forests

    NASA Astrophysics Data System (ADS)

    Huang, Maoyi; Asner, Gregory P.

    2010-09-01

    Amazon deforestation contributes significantly to global carbon (C) emissions. In comparison, the contribution from selective logging to atmospheric CO2 emissions, and its impact on regional C dynamics, is highly uncertain. Using a new geographically based modeling approach in combination with high resolution remote sensing data from 1999 to 2002, we estimate that C emissions were 0.04-0.05 Pg C yr-1 due to selective logging from a ˜2,664,960 km2 region of the Brazilian Amazon. Selective logging was responsible for 15-19% higher carbon emissions than reported from deforestation (clear-cutting) alone. Our simulations indicated that forest carbon lost via selective logging lasts two to three decades following harvest, and that the original live biomass takes up to a century to recover, if the forests are not subsequently cleared. The two- to three-decade loss of carbon results from the biomass damaged by logging activities, including leaves, wood, and roots, estimated to be 89.1 Tg C yr-1 from 1999 to 2002 over the study region, leaving 70.0 Tg C yr-1 and 7.9 Tg C yr-1 to accumulate as coarse woody debris and soil C, respectively. While avoided deforestation is central to crediting rain forest nations for reduced carbon emissions, the extent and intensity of selective logging are also critical to determining carbon emissions in the context of Reduced Emissions from Deforestation and Forest Degradation (REDD). We show that a combination of automated high-resolution satellite monitoring and detailed forest C modeling can yield spatially explicit estimates of harvest-related C losses and subsequent recovery in support of REDD and other international carbon market mechanisms.

  9. Long-term Carbon Loss and Recovery Following Selective Logging in Amazon Forests

    SciTech Connect

    Huang, Maoyi; Asner, Gregory P.

    2010-09-30

    Amazon deforestation contributes significantly to global carbon (C) emissions. In comparison, the contribution from selective logging to atmospheric CO2 emissions, and its impact on regional C dynamics, is highly uncertain. Using a new geographically-based modeling approach in combination with high resolution remote sensing data from 1999-2002, we estimate that C emissions were 0.04 – 0.05 Pg C yr-1 due to selective logging from a ~2,664,960 km2 region of the Brazilian Amazon. Selective logging was responsible for 15-19% higher carbon emissions than reported from deforestation (clear-cutting) alone. Our simulations indicated that forest carbon lost via selective logging lasts two to three decades following harvest, and that the original live biomass takes up to a century to recover, if the forests are not subsequently cleared. The two- to three-decade loss of carbon results from the biomass damaged by logging activities, including leaves, wood, and roots, estimated to be 89.1 Tg C yr-1 from 1999-2002 over the study region, leaving 70.0 Tg C yr-1 and 7.9 Tg C yr-1 to accumulate as coarse woody debris and soil C, respectively. While avoided deforestation is central to crediting rainforest nations for reduced carbon emissions, the extent and intensity of selective logging are also critical to determining carbon emissions in the context of Reduced Emissions from Deforestation and Forest Degradation (REDD). We show that a combination of automated high-resolution satellite monitoring and detailed forest C modeling can yield spatially explicit estimates of harvest related C losses and subsequent recovery in support of REDD and other international carbon market mechanisms.

  10. Log Normal Distribution of Cellular Uptake of Radioactivity: Statistical Analysis of Alpha Particle Track Autoradiography

    PubMed Central

    Neti, Prasad V.S.V.; Howell, Roger W.

    2008-01-01

    Recently, the distribution of radioactivity among a population of cells labeled with 210Po was shown to be well described by a log normal distribution function (J Nucl Med 47, 6 (2006) 1049-1058) with the aid of an autoradiographic approach. To ascertain the influence of Poisson statistics on the interpretation of the autoradiographic data, the present work reports on a detailed statistical analyses of these data. Methods The measured distributions of alpha particle tracks per cell were subjected to statistical tests with Poisson (P), log normal (LN), and Poisson – log normal (P – LN) models. Results The LN distribution function best describes the distribution of radioactivity among cell populations exposed to 0.52 and 3.8 kBq/mL 210Po-citrate. When cells were exposed to 67 kBq/mL, the P – LN distribution function gave a better fit, however, the underlying activity distribution remained log normal. Conclusions The present analysis generally provides further support for the use of LN distributions to describe the cellular uptake of radioactivity. Care should be exercised when analyzing autoradiographic data on activity distributions to ensure that Poisson processes do not distort the underlying LN distribution. PMID:16741316

  11. Surface modification of MAl2O4:Eu2+,Dy3+ (M = Sr, Ca, Ba) phosphors to enhance water resistance by combustion method

    NASA Astrophysics Data System (ADS)

    Deng, Suqing; Xue, Zhiping; Yang, Qu; Liu, Yingliang; Lei, Bingfu; Xiao, Yong; Zheng, Mingtao

    2013-10-01

    A facile combustion method was introduced into surface modification of MAl2O4:Eu2+,Dy3+ (M = Sr, Ca, Ba) phosphors to improve their water resistance. X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), high-resolution transmission electron microscopy (HRTEM), pH measurements and photoluminescence (PL) spectrophotometry were used to characterize the phosphors before and after modification, respectively. Experimental results showed that compact layer of MAl2B2O7 (M = Sr, Ca, Ba) substance was formed on the surface of aluminate phosphors by direct chemical reaction between aluminate and boracic acid. MAl2B2O7 (M = Sr, Ca, Ba) substance is chemically stable in water and could improve water resistance of aluminate phosphors effectively with little influence of luminescence property. It was considered that the versatility of combustion method for surface modification of aluminate phosphors has been confirmed.

  12. Alternative splicing of human T-cell-specific MAL mRNA and its correlation with the exon/intron organization of the gene

    SciTech Connect

    Rancano, C.; Rubio, T.; Alonso, M.A. )

    1994-05-15

    Sequence analysis of the T-cell-specific MAL gene revealed four exons, each encoding a hydrophobic, presumably membrane-associated, segment and its adjacent hydrophilic sequence. Amplification by the polymerase chain reaction of cDNA from different T-cell samples indicated the existence of four different forms of MAL mRNA, termed MAL-a, -b, -c, and -d, that arise from differential usage of exons II and/or III. As the three introns were located between complete codons, the reading frame was maintained in all the transcripts. A model resembling the structures postulated for different proteolipid proteins is proposed for the protein encoded by each alternative mRNA species. 9 refs., 3 figs.

  13. Tuberculose ostéoarticulaire (mal de Pott exclu): à propos de 120 cas à Abidjan

    PubMed Central

    Gbané-Koné, Mariam; Koné, Samba; Ouali, Boubacar; Djaha, Kouassi Jean -Mermoz; Akoli, Ekoya Ondzala; Nseng, Ingrid Nseng; Eti, Edmond; Daboiko, Jean Claude; Touré, Stanislas André; Kouakou, N'zué Marcel

    2015-01-01

    Introduction La tuberculose ostéoarticulaire (TOA) représente 2 à 5% de l'ensemble des tuberculoses. Elle demeure d'actualité surtout dans les pays à forte endémicité tuberculeuse. L'objectif était de déterminer la prévalence, les aspects topographiques, radiologiques de la TOA en milieu hospitalier ivoirien. Méthodes Les auteurs rapportent une expérience de 11 ans, à travers une étude rétrospective de 120 dossiers de patients atteints de la tuberculose ostéoarticulaire (le mal de Pott est exclu de cette étude). N'ont pas été inclus dans l’étude les dossiers ne comportant pas d'imagerie. Résultats L'atteinte extra vertébrale représentait 09,2% de la tuberculose ostéoarticulaire. Il s'agissait de 54 hommes et 66 femmes, l’âge moyen était de 43,13 ans. On notait 123 cas d'ostéoarthrites, et 8 cas d'ostéites des os plats. L'atteinte des membres inférieurs prédominait dans 91,87% des cas. La hanche était la première localisation (45,04%), suivie du genou (25,19%). Les atteintes étaient multifocales dans 20% des cas. L'atteinte osseuse était associée à une tuberculose pulmonaire dans 05,83% des cas. Des localisations inhabituelles ont été rapportées: poignet (n = 2), branches ischiopubiennes (n = 4), atteinte sternoclaviculaire (n = 4), médiopieds (n = 2). Les lésions radiologiques étaient avancées (stades III et IV) dans 55,73% des cas. A la TDM, la prévalence des abcès était de 77%. Un geste chirurgical a été réalisé sur 16 articulations (2 épaules, 13 genoux, une cheville). Conclusion La TOA des membres est peu fréquente contrairement à l'atteinte vertébrale. La hanche est la principale localisation. Le retard au diagnostic explique l’étendue des lésions anatomoradiologiques. PMID:26587129

  14. EJERCICIO Y LA DETECCION DEL MAL AGUDO DE MONTAÑA GRAVE

    PubMed Central

    Garófoli, Adrián; Montoya, Paola; Elías, Carlos; Benzo, Roberto

    2012-01-01

    El Mal Agudo de Montaña (MAM) es un conjunto de síntomas inespecíficos padecidos por sujetos que ascienden rápidamente desde baja a alta altura sin adecuada aclimatación. Usualmente es autolimitado, pero las formas graves (edema pulmonar y cerebral) pueden causar la muerte. La hipoxemia exagerada en reposo está relacionada con el desarrollo de MAM pero su valor predictivo es limitado. Dado que el ejercicio en altura se acompaña de mayor hipoxemia y síntomas, postulamos el valor predictivo de un simple test de ejercicio para pronosticar MAM grave. Se estudió el valor predictivo de la saturación de oxígeno en reposo y ejercicio submáximo a 2 700m y 4 300m en 63 sujetos que ascendían al cerro Aconcagua (6 962m). Se consideró desaturación de oxígeno con ejercicio a una disminución >=5% respecto al reposo. Se utilizó la escala de Lake-Louise para establecer la presencia de MAM grave. 6 sujetos presentaron MAM grave (9.5%) y requirieron evacuación. La saturación de oxígeno en reposo a 2 700m no fue significativa para clasificar sujetos que luego desarrollaron MAM grave. Por el contrario, la asociación de desaturación durante el ejercicio a 2 700m más la saturación inapropiada en reposo a 4 300m fue significativa para clasificar a los sujetos que desarrollaron MAM grave con un valor predictivo positivo de 80% y un valor predictivo negativo del 97%. Nuestros resultados son relevantes para el montañismo y sugieren la adición de un simple test de ejercicio en la predicción del MAM grave. PMID:20228017

  15. Extracting the Textual and Temporal Structure of Supercomputing Logs

    SciTech Connect

    Jain, S; Singh, I; Chandra, A; Zhang, Z; Bronevetsky, G

    2009-05-26

    Supercomputers are prone to frequent faults that adversely affect their performance, reliability and functionality. System logs collected on these systems are a valuable resource of information about their operational status and health. However, their massive size, complexity, and lack of standard format makes it difficult to automatically extract information that can be used to improve system management. In this work we propose a novel method to succinctly represent the contents of supercomputing logs, by using textual clustering to automatically find the syntactic structures of log messages. This information is used to automatically classify messages into semantic groups via an online clustering algorithm. Further, we describe a methodology for using the temporal proximity between groups of log messages to identify correlated events in the system. We apply our proposed methods to two large, publicly available supercomputing logs and show that our technique features nearly perfect accuracy for online log-classification and extracts meaningful structural and temporal message patterns that can be used to improve the accuracy of other log analysis techniques.

  16. Numerical simulation of responses for cased-hole density logging

    NASA Astrophysics Data System (ADS)

    Wu, Wensheng; Fu, Yaping; Niu, Wei

    2013-10-01

    Stabilizing or stimulating oil production in old oil fields requires density logging in cased holes where open-hole logging data are either missing or of bad quality. However, measured values from cased-hole density logging are more severely influenced by factors such as fluid, casing, cement sheath and the outer diameter of the open-hole well compared with those from open-hole logging. To correctly apply the cased-hole formation density logging data, one must eliminate these influences on the measured values and study the characteristics of how the cased-hole density logging instrument responds to these factors. In this paper, a Monte Carlo numerical simulation technique was used to calculate the responses of the far detector of a cased-hole density logging instrument to in-hole fluid, casing wall thickness, cement sheath density and the formation and thus to obtain influence rules and response coefficients. The obtained response of the detector is a function of in-hole liquid, casing wall thickness, the casing's outer diameter, cement sheath density, open-hole well diameter and formation density. The ratio of the counting rate of the detector in the calibration well to that in the measurement well was used to get a fairly simple detector response equation and the coefficients in the equation are easy to acquire. These provide a new way of calculating cased-hole density through forward modelling methods.

  17. Geophysical Logs of Selected Wells at the Diaz Chemical Superfund Site in the Village of Holley, New York, 2009

    USGS Publications Warehouse

    Eckhardt, David A.V.; Anderson, J. Alton

    2010-01-01

    Geophysical logs were collected and analyzed to define the bedrock fracture patterns and flow zones penetrated by three wells at the Diaz Chemical Superfund Site in the Village of Holley in Orleans County, New York. The work was conducted in December 2009 as part of the investigation of contamination by organic compounds in the shale, mudstone, and sandstone bedrock at the Site. The geophysical logs include natural-gamma, caliper, borehole image, fluid properties, and flowmeter data. The orientation of fractures in the boreholes was inferred from the log data and summarized in stereo and tadpole plots; when possible, the transmissivity and hydraulic head was also determined for fracture zones that were observed to be hydraulically active through the flowmeter logs. The data are intended, in part, for use in the remediation of the site.

  18. New Techniques: Muon Glaciology and Ultrasonic Logging

    NASA Astrophysics Data System (ADS)

    Chirkin, D.; Allen, J.; Bay, R. C.; Bramall, N.; Price, P. B.

    2003-12-01

    The strain rate of cold glacial ice depends mainly on the stress tensor, temperature, grain size, and crystal habit. Lab measurements cannot be made at both the low stresses and low temperatures relevant to flow of cold glacial ice. Field studies with inclinometers measure only the horizontal components of flow. We have developed a new method for measuring the 3D strain-rate field at -40o to -15oC, using the AMANDA neutrino-detecting array frozen into deep ice at South Pole. Each strain detector consists of a photomultiplier tube (PMT) in its pressure vessel. AMANDA has ˜600 PMTs at depths 1500 to 2300 m in a ˜0.02 km3 volume. The coordinates of each PMT relative to a coordinate system moving down slope at 9 m yr-1 can be measured with s.d. <1 m in 1 day by mapping trajectories of down-going cosmic-ray muons that pass through the array. The PMTs record the arrival times of the Cherenkov light emitted along the muon trajectory. Use of maximum likelihood for 105 muon tracks allows PMT positions to be determined; their positions are then updated at six-month intervals. We will report results of strain-rate measurements in three dimensions, made in 2000, 2001, and 2002 at T ≈ -30oC. Applying the same technique to the future 1 km3 IceCube array, by averaging over subsets of the 5000 detectors, values of the strain-rate tensor as small as 3x 10-5 yr-1 can be measured as a function of temperature and lateral position. The vertical strain rate due to snow accumulation, estimated to be ˜ 3x 10-5 yr-1, can be measured and will serve as a check on the method. The second new method is designed to measure mean grain size in the ice surrounding a borehole. We will adapt an all-digital logging tool originally developed by Advanced Logic Technology (Luxembourg) for geophysics prospecting in rock boreholes. A 1.3 MHz transducer emits acoustic pulses horizontally into the ice in increments of 5o in azimuth and records the wave train back-scattered from grain boundaries. For

  19. Triangulated Mal-Signaling in Alzheimer's Disease: Roles of Neurotoxic Ceramides, ER Stress, and Insulin Resistance Reviewed

    PubMed Central

    de la Monte, Suzanne M.

    2015-01-01

    Ceramides are lipid signaling molecules that cause cytotoxicity and cell death mediated by insulin resistance, inflammation, and endoplasmic reticulum (ER) stress. However, insulin resistance dysregulates lipid metabolism, which promotes ceramide accumulation with attendant inflammation and ER stress. Herein, we discuss two major pathways, extrinsic and intrinsic, that converge and often overlap in propagating AD-type neurodegeneration via a triangulated mal-signaling network. First, we review evidence that systemic insulin resistance diseases linked to obesity, type 2 diabetes, and non-alcoholic steatohepatitis promote neurodegeneration. Mechanistically, we propose that toxic ceramides generated in extra-CNS tissues (e.g., liver) get released into peripheral blood, and subsequently transit across the blood-brain barrier into the brain where they induce brain insulin resistance, inflammation, and cell death (extrinsic pathway). Then we discuss the role of the intrinsic pathway of neurodegeneration which is mediated by endogenous or primary brain insulin/IGF resistance, and impairs neuronal and oligodendrocyte survival, energy metabolism, membrane integrity, cytoskeletal function, and AβPP-Aβ secretion. The end result is increased ER stress and ceramide generation, which exacerbate brain insulin resistance, cell death, myelin degeneration, and neuroinflammation. Altogether, the data suggest that the triangulated mal-signaling network mediated by toxic ceramides, ER stress, and insulin resistance should be targeted to disrupt positive feedback loops that drive the AD neurodegeneration cascade. PMID:22337830

  20. LogCauchy, log-sech and lognormal distributions of species abundances in forest communities

    USGS Publications Warehouse

    Yin, Z.-Y.; Peng, S.-L.; Ren, H.; Guo, Q.; Chen, Z.-H.

    2005-01-01

    Species-abundance (SA) pattern is one of the most fundamental aspects of biological community structure, providing important information regarding species richness, species-area relation and succession. To better describe the SA distribution (SAD) in a community, based on the widely used lognormal (LN) distribution model with exp(-x2) roll-off on Preston's octave scale, this study proposed two additional models, logCauchy (LC) and log-sech (LS), respectively with roll-offs of simple x-2 and e-x. The estimation of the theoretical total number of species in the whole community, S*, including very rare species not yet collected in sample, was derived from the left-truncation of each distribution. We fitted these three models by Levenberg-Marquardt nonlinear regression and measured the model fit to the data using coefficient of determination of regression, parameters' t-test and distribution's Kolmogorov-Smirnov (KS) test. Examining the SA data from six forest communities (five in lower subtropics and one in tropics), we found that: (1) on a log scale, all three models that are bell-shaped and left-truncated statistically adequately fitted the observed SADs, and the LC and LS did better than the LN; (2) from each model and for each community the S* values estimated by the integral and summation methods were almost equal, allowing us to estimate S* using a simple integral formula and to estimate its asymptotic confidence internals by regression of a transformed model containing it; (3) following the order of LC, LS, and LN, the fitted distributions became lower in the peak, less concave in the side, and shorter in the tail, and overall the LC tended to overestimate, the LN tended to underestimate, while the LS was intermediate but slightly tended to underestimate, the observed SADs (particularly the number of common species in the right tail); (4) the six communities had some similar structural properties such as following similar distribution models, having a common