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Sample records for activity pa participation

  1. What are the factors associated with physical activity (PA) participation in community dwelling adults with dementia? A systematic review of PA correlates.

    PubMed

    Stubbs, Brendon; Eggermont, Laura; Soundy, Andrew; Probst, Michel; Vandenbulcke, Mathieu; Vancampfort, Davy

    2014-01-01

    PA shows promise as a modifiable lifestyle intervention to benefit pathological symptoms of dementia. However, little is known about the factors associated with participation in PA in community dwelling adults with dementia. A systematic review was undertaken to identify PA correlates. Two independent reviewers searched major electronic databases and extracted data on studies reporting quantitative correlates of PA participation in community dwelling adults with dementia. PA correlates were analyzed using the summary code approach within the socio-ecological model. Out of a potential of 118 articles, 12 met the eligibility criteria encompassing 752 participants. We conducted secondary analysis on nine data sets. Increased energy intake, resting metabolic rate, fat free mass, gait speed, global motor function, overall health related quality of life (HRQOL), physical HRQOL, higher levels of social functioning and reduced apathy were positively associated with PA. Taking ≥ four medications, dizziness, lower activities of daily living (ADL) function, a history of falls, less waking hours in the day, more autonomic problems and delirium were negatively associated with PA. Increasing age and lower global cognition were not consistently associated with PA participation. It is surprising that increasing age and lower global cognition do not appear to influence PA participation. All significant correlates should be confirmed in prospective studies with particular focus on the relationship of PA and gait speed, ADL function, falls history and dietary intake and the progression of frailty and nursing home admission as a priority.

  2. Physical activity participation in African American churches.

    PubMed

    Bopp, Melissa; Wilcox, Sara; Laken, Marilyn; McClorin, Lottie

    2009-01-01

    The potential benefit of physical activity (PA) programs delivered through churches is largely unexamined. This study examined availability of PA programs, interpersonal support for PA, and PA participation in African-American churches. Individuals from a random sample of 20 churches in South Carolina participated in a telephone survey (N = 571). Forty two percent of respondents reported PA programs at their churches. Walking programs (20%), aerobics (22%) or a combination of both (20%) were most common. Respondents who reported having these programs were more likely to meet PA recommendations than those who did not (p = 0.05). Larger churches were more likely to offer PA programs (p = 0.02) than small or medium sized churches. Only 24% of respondents had spoken with the health director at their church about participating in a PA program, and only 25% and 33% had ever spoken with another church member about a PA program or were encouraged to join a PA program, respectively. Individuals with more interpersonal support from other church members for PA were significantly more likely to meet PA recommendations (p = 0.01). This study indicates that program and interpersonal supports within African American churches may offer a venue for increasing PA among members.

  3. Proteasome activators, PA28γ and PA200, play indispensable roles in male fertility

    PubMed Central

    Huang, Lin; Haratake, Kousuke; Miyahara, Hatsumi; Chiba, Tomoki

    2016-01-01

    Protein degradation mediated by the proteasome is important for the protein homeostasis. Various proteasome activators, such as PA28 and PA200, regulate the proteasome function. Here we show double knockout (dKO) mice of Psme3 and Psme4 (genes for PA28γ and PA200), but not each single knockout mice, are completely infertile in male. The dKO sperms exhibited remarkable defects in motility, although most of them showed normal appearance in morphology. The proteasome activity of the mutant sperms decreased notably, and the sperms were strongly positive with ubiquitin staining. Quantitative analyses of proteins expressed in dKO sperms revealed up-regulation of several proteins involved in oxidative stress response. Furthermore, increased 8-OHdG staining was observed in dKO sperms head, suggesting defective response to oxidative damage. This report verified PA28γ and PA200 play indispensable roles in male fertility, and provides a novel insight into the role of proteasome activators in antioxidant response. PMID:27003159

  4. Microglial tissue plasminogen activator (tPA) triggers neuronal apoptosis in vitro.

    PubMed

    Flavin, M P; Zhao, G; Ho, L T

    2000-02-15

    Several CNS disorders feature microglial activation. Microglia are known to have both restorative and cytotoxic capabilities. Neuronal apoptosis has been noted after an acute insult such as ischemia. Microglia may participate in this event. We previously showed that conditioned medium (CM) harvested from peritoneal macrophages or from activated microglia triggered apoptosis in rat hippocampal neurons in culture. We wished to characterize the factor responsible for triggering neuronal death. Quiescent microglia produced CM that did not disrupt hippocampal neurons. Lipopolysaccharide-activated microglia produced CM which resulted in neuronal death. This effect was blocked by plasminogen activator inhibitor-1, by tPA STOP, and by co-incubation with tPA antibody. Recombinant human tPA exaggerated the neurotoxic effects of microglial CM, while tPA alone was toxic only at very high concentrations. This in vitro system, which probably excludes any significant impact of microglial free radicals, suggests that microglial tPA may contribute significantly to hippocampal neuronal death.

  5. Formation of proteasome-PA700 complexes directly correlates with activation of peptidase activity.

    PubMed

    Adams, G M; Crotchett, B; Slaughter, C A; DeMartino, G N; Gogol, E P

    1998-09-15

    The proteolytic activity of the eukaryotic 20S proteasome is stimulated by a multisubunit activator, PA700, which forms both 1:1 and 2:1 complexes with the proteasome. Formation of the complexes is enhanced by an additional protein assembly called modulator, which also stimulates the enzymatic activity of the proteasome only in the presence of PA700. Here we show that the binding of PA700 to the proteasome is cooperative, as is the activation of the proteasome's intrinsic peptidase activity. Modulator increases the extent of complex formation and peptidase activation, while preserving the cooperative kinetics. Furthermore, the increase in activity is not linear with the number of PA700 assemblies bound to the proteasome, but rather with the number of proteasome-PA700 complexes, regardless of the PA700:proteasome stoichiometry. Hence the stimulation of peptidase activity is fully (or almost fully) effected by the binding of a single PA700 to the 20S proteasome. The stimulation of peptidase by modulator is explained entirely by the increased number of proteasome-PA700 complexes formed in its presence, rather than by any substantial direct stimulation of catalysis. These observations are consistent with a model in which PA700, either alone or assisted by modulator, promotes conformational changes in the proteasome that activate the catalytic sites and/or facilitate access of peptide substrates to these sites. PMID:9737872

  6. Parent participation plays an important part in promoting physical activity

    PubMed Central

    Lindqvist, Anna-Karin; Kostenius, Catrine; Gard, Gunvor; Rutberg, Stina

    2015-01-01

    Although physical activity (PA) is an important and modifiable determinant of health, in Sweden only 15% of boys and 10% of girls aged 15 years old achieve the recommended levels of PA 7 days per week. Adolescents’ PA levels are associated with social influence exerted by parents, friends, and teachers. The purpose of this study was to describe parents’ experiences of being a part of their adolescents’ empowerment-inspired PA intervention. A qualitative interview study was performed at a school in the northern part of Sweden. A total of 10 parents were interviewed, and the collected data were analyzed with qualitative content analysis. Three subthemes were combined into one main theme, demonstrating that parents are one important part of a successful PA intervention. The life of an adolescent has many options and demands that make it difficult to prioritize PA. Although parents felt that they were important in supporting their adolescent, a successful PA intervention must have multiple components. Moreover, the parents noted that the intervention had a positive effect upon not only their adolescents’, but also their own PA. Interventions aimed at promoting PA among adolescents should include measures to stimulate parent participation, have an empowerment approach, and preferably be school-based. PMID:26282870

  7. Association of After-School Physical Activity Levels and Organized Physical Activity Participation in Hong Kong Children

    ERIC Educational Resources Information Center

    Cheung, Peggy PY

    2012-01-01

    The aims of this study were to 1) describe the children's physical activity (PA) patterns during the after-school period and 2) to compare the type and intensity of activity during the after-school period of children with or without participation in organized PA programmes. The participants were 456 children from four primary schools in Hong Kong.…

  8. Phosphatidic acid (PA) binds PP2AA1 to regulate PP2A activity and PIN1 polar localization.

    PubMed

    Gao, Hong-Bo; Chu, Yu-Jia; Xue, Hong-Wei

    2013-09-01

    Phospholipase D (PLD) exerts broad biological functions in eukaryotes through regulating downstream effectors by its product, phosphatidic acid (PA). Protein kinases and phosphatases, such as mammalian target of rapamycin (mTOR), Protein Phosphatase 1 (PP1) and Protein Phosphatase 2C (PP2C), are PA-binding proteins that execute crucial regulatory functions in both animals and plants. PA participates in many signaling pathways by modulating the enzymatic activity and/or subcellular localization of bound proteins. In this study, we demonstrated that PLD-derived PA interacts with the scaffolding A1 subunit of Protein Phosphatase 2A (PP2A) and regulates PP2A-mediated PIN1 dephosphorylation in Arabidopsis. Genetic and pharmacological studies showed that both PA and PP2A participate in the regulation of auxin distribution. In addition, both the phosphorylation status and polar localization of PIN1 protein were affected by PLD inhibitors. Exogenous PA triggered the membrane accumulation of PP2AA1 and enhanced the PP2A activity at membrane, while PLD inhibition resulted in the reduced endosomal localization and perinuclear aggregation of PP2AA1. These results demonstrate the important role of PLD-derived PA in normal PP2A-mediated PIN dephosphorylation and reveal a novel mechanism, in which PA recruits PP2AA1 to the membrane system and regulates PP2A function on membrane-targeted proteins. As PA and PP2A are conserved among eukaryotes, other organisms might use similar mechanisms to mediate multiple biological processes.

  9. Crystal structure of an avian influenza polymerase PA[subscript N] reveals an endonuclease active site

    SciTech Connect

    Yuan, Puwei; Bartlam, Mark; Lou, Zhiyong; Chen, Shoudeng; Zhou, Jie; He, Xiaojing; Lv, Zongyang; Ge, Ruowen; Li, Xuemei; Deng, Tao; Fodor, Ervin; Rao, Zihe; Liu, Yingfang

    2009-11-10

    The heterotrimeric influenza virus polymerase, containing the PA, PB1 and PB2 proteins, catalyses viral RNA replication and transcription in the nucleus of infected cells. PB1 holds the polymerase active site and reportedly harbours endonuclease activity, whereas PB2 is responsible for cap binding. The PA amino terminus is understood to be the major functional part of the PA protein and has been implicated in several roles, including endonuclease and protease activities as well as viral RNA/complementary RNA promoter binding. Here we report the 2.2 angstrom (A) crystal structure of the N-terminal 197 residues of PA, termed PA(N), from an avian influenza H5N1 virus. The PA(N) structure has an alpha/beta architecture and reveals a bound magnesium ion coordinated by a motif similar to the (P)DX(N)(D/E)XK motif characteristic of many endonucleases. Structural comparisons and mutagenesis analysis of the motif identified in PA(N) provide further evidence that PA(N) holds an endonuclease active site. Furthermore, functional analysis with in vivo ribonucleoprotein reconstitution and direct in vitro endonuclease assays strongly suggest that PA(N) holds the endonuclease active site and has critical roles in endonuclease activity of the influenza virus polymerase, rather than PB1. The high conservation of this endonuclease active site among influenza strains indicates that PA(N) is an important target for the design of new anti-influenza therapeutics.

  10. Low-Temperature Curable Photo-Active Anisotropic Conductive Films (PA-ACFs)

    NASA Astrophysics Data System (ADS)

    Kim, Il; Paik, Kyung-Wook

    2014-09-01

    Photo-active anisotropic conductive films (PA-ACFs) with curing temperatures below 120°C were introduced using photo-active curing agents. The PA-ACFs showed no curing before UV activation, and the crosslinking systems of the PA-ACFs were not activated under fluorescent light exposure. However, after UV activation, the PA-ACFs were completely cured at 120°C within 10 s. Flex-on-board (FOB) assembly using PA-ACFs had adhesion strength and joint resistances similar to those of the FOB assemblies using conventional epoxy-based ACFs. This study demonstrates that PA-ACFs provide reliable interconnection and minimal thermal deformation among all the commercially available ACFs, especially for low T g substrate applications.

  11. Male Adolescents' Reasons for Participating in Physical Activity, Barriers to Participation, and Suggestions for Increasing Participation

    ERIC Educational Resources Information Center

    Allison, Kenneth R.; Dwyer, John J. M.; Goldenberg, Ellie; Fein, Allan; Yoshida, Karen K.; Boutilier, Marie

    2005-01-01

    This study explored male adolescents' reasons for participating in moderate and vigorous physical activity, perceived barriers to moderate and vigorous physical activity, and suggestions as to what can be done to increase participation in physical activity. A total of 26 male 15- and 16-year-old adolescents participated in focus group sessions,…

  12. Effects of Partners Together in Health (PaTH) Intervention on Physical Activity and Healthy Eating Behaviors: A Pilot Study

    PubMed Central

    Yates, Bernice C.; Norman, Joseph; Meza, Jane; Krogstrand, Kaye Stanek; Harrington, Susana; Shurmur, Scott; Johnson, Matthew; Schumacher, Karen

    2014-01-01

    Background Despite proven efficacy of cardiac rehabilitation (CR) in helping patients initiate physical activity and healthy eating changes, less than 50% of CR participants maintain changes 6 months later. Objective The objective of this feasibility study was to test the Partners Together in Health (PaTH) Intervention versus usual care (UC) in improving physical activity and healthy eating behaviors in coronary artery bypass graft (CABG) surgery patients and spouses. Methods An experimental, two-group (n = 17 couples/group), repeated measures design was used. CABG patients in both groups participated in Phase II outpatient CR. Spouses in the PaTH group attended CR with the patient and were asked to make the same physical activity and healthy eating changes as patients. Spouses in the control group attended educational classes with patients. It was theorized that “two persons would be better than one” at making changes and sticking with them long-term. Physical activity behavior was measured using the Actiheart accelerometer; the activity biomarker was an exercise tolerance test. Eating behavior was measured using 3-day food records; the biomarker was the lipid profile. Data were collected at baseline (entrance in CR), 3-months (post-CR), and 6-months. Changes over time were examined using Mann-Whitney U statistics and effect sizes. Results The PaTH intervention was successful primarily in demonstrating improved trends in healthy eating behavior for patients and spouses. No differences were found between the PaTH and UC patients or spouses at 3 or 6 months in the number of minutes/week of physical activity. By 6 months, patients in both groups were, on average, below the national guidelines for PA recommendations (≥ 150 min/week at > 3 METs). Conclusions The couple-focused PaTH intervention demonstrated promise in offsetting the decline in dietary adherence typically seen 6 months after CR. PMID:24434826

  13. Thrombolytic efficacy and enzymatic activity of rt-PA-loaded echogenic liposomes.

    PubMed

    Bader, Kenneth B; Bouchoux, Guillaume; Peng, Tao; Klegerman, Melvin E; McPherson, David D; Holland, Christy K

    2015-08-01

    Echogenic liposomes (ELIP), that can encapsulate both recombinant tissue-type plasminogen activator (rt-PA) and microbubbles, are under development to improve the treatment of thrombo-occlusive disease. However, the enzymatic activity, thrombolytic efficacy, and stable cavitation activity generated by this agent has yet to be evaluated and compared to another established ultrasound-enhanced thrombolytic scheme. A spectrophotometric method was used to compare the enzymatic activity of the rt-PA incorporated into ELIP (t-ELIP) to that of rt-PA. An in vitro flow model was employed to measure the thrombolytic efficacy and dose of ultraharmonic emissions from stable cavitation for 120-kHz ultrasound exposure of three treatment schemes: rt-PA, rt-PA and the perfluorocarbon-filled microbubble Definity(®), and t-ELIP. The enzymatic activity of rt-PA incorporated into t-ELIP was 28 % that of rt-PA. Thrombolytic efficacy of t-ELIP or rt-PA and Definity(®) was equivalent when the dose of t-ELIP was adjusted to produce comparable enzymatic activity. Sustained bubble activity was nucleated from Definity but not from t-ELIP exposed to 120-kHz ultrasound. These results emphasize the advantages of encapsulating a thrombolytic and the importance of incorporating an insoluble gas required to promote sustained, stable cavitation activity.

  14. Reliability of the modified child and adolescent physical activity and nutrition survey, physical activity (CAPANS-PA) questionnaire among chinese-australian youth

    PubMed Central

    2011-01-01

    Background Evidence suggests that differences exist in physical activity (PA) participation among Culturally and Linguistically Diverse (CALD) children and adolescents. It is possible that these differences could be influenced by variations in measurement technique and instrument reliability. However, culturally sensitive instruments for examining PA behaviour among CALD populations are lacking. This study tested the reliability of the Child and Adolescent Physical Activity and Nutrition Survey (CAPANS-PA) recall questionnaire among a sample of Chinese-Australian youth. Methods The psychometric property of the CAPANS-PA questionnaire was examined among a sample of 77 Chinese-Australian youth (aged 11 - 14 y) who completed the questionnaire twice within 7 days. Test-retest reliability of individual items and scales within the CAPANS-PA questionnaire was determined using Kappa statistics for categorical variables and intraclass correlation coefficients (ICC) for continuous variables. Results The CAPANS-PA questionnaire demonstrated acceptable test-retest reliability for frequency and duration of time spent in weekly Moderate to Vigorous Physical Activity (MVPA) (ICC ≥ 0.70) for all participants. Test-retest reliability for time spent in weekly sedentary activities was acceptable for females (ICC = 0.82) and males (ICC = 0.72). Conclusions The results suggest the CAPANS-PA questionnaire provides reliable estimates for type, frequency and duration of MVPA participation among Chinese-Australian youth. Further investigation into the reliability of the sedentary items within the CAPANS-PA is required before these items can be used with confidence. This study is novel in that the reliability of instruments among CALD groups nationally and internationally remains sparse and this study contributes to the wider body of available psychometrically tested instruments. In addition, this study is the first to our knowledge to successfully engage and investigate the basic health

  15. Adolescent Girls' Participation in Physical Activity.

    ERIC Educational Resources Information Center

    Butcher, Janice; Hall, M. Ann

    A longitudinal study of girls from the sixth through tenth grades sought to determine if the extent and type of participation in physical activities changed with age. A sample of 207 girls was selected with 140 completing the survey over 5 years. Participation was measured by activities in interschool teams, intramural activities,…

  16. Molecular and functional characterization of a putative PA28γ proteasome activator orthologue in Schistosoma mansoni

    PubMed Central

    Soares, Cláudia Sossai; Morais, Enyara Rezende; Magalhães, Lizandra G.; Machado, Carla Botelho; Moreira, Érika Bueno de Carvalho; Teixeira, Felipe Roberti; Rodrigues, Vanderlei; Yoshino, Timothy P.

    2013-01-01

    PA28γ is a proteasome activator involved in the regulation of the cellular proliferation, differentiation and growth. In the present study, we identified and characterized a cDNA from Schistosoma mansoni exhibiting significant homology to PA28γ of diverse taxa ranging from mammals (including humans) to simple invertebrates. Designated SmPA28γ, this transcript has a 753 bp predicted ORF encoding a protein of 250 amino acid residues. Alignment of SmPA28γ with multiple PA28γ orthologues revealed an average similarity of ~40% among the investigated organisms, and 90% similarity with PA28γ from Schistosoma japonicum. In addition, phylogenetic analysis demonstrated a close linkage between SmPA28γ to its sister group that contains well-characterized PA28γ sequences from Drosophila spp., as well as sharing the same branch with PA28γ from S. japonicum. Gene expression profiling of SmPA28γ using real-time quantitative PCR revealed elevated steady-state transcript levels in the eggs, miracidia and paired adult worms compared to other stages. In parallel with gene expression profiles, an affinity-purified anti-SmPA28γ antibody produced against recombinant protein exhibited strongest reactivity in Western blot analyses to endogenous SmPA28γ from miracidia, sporocysts and paired adult worms. Given its known regulatory function in other organisms, we hypothesized that the high level of SmPA28γ transcript and protein in these stages may be correlated with an important role of the PA28γ in the cellular growth and/or development of this parasite. To address this hypothesis, miracidia were transformed in vitro to sporocysts in the presence of SmPA28γ double-stranded RNAs (dsRNAs) and cultivated for 4 days, after which time steady-state transcript and protein levels, and phenotypic changes were evaluated. SmPA28γ dsRNA treatment resulted in gene and protein knockdown of ~60% and ~80%, respectively, which were correlated with a significant decrease in larval length

  17. Conformations of tissue plasminogen activator (tPA) orchestrate neuronal survival by a crosstalk between EGFR and NMDAR

    PubMed Central

    Bertrand, T; Lesept, F; Chevilley, A; Lenoir, S; Aimable, M; Briens, A; Hommet, Y; Bardou, I; Parcq, J; Vivien, D

    2015-01-01

    Tissue-type plasminogen activator (tPA) is a pleiotropic serine protease of the central nervous system (CNS) with reported neurotrophic and neurotoxic functions. Produced and released under its single chain form (sc), the sc-tPA can be cleaved by plasmin or kallikrein in a two chain form, tc-tPA. Although both sc-tPA and tc-tPA display a similar fibrinolytic activity, we postulated here that these two conformations of tPA (sc-tPA and tc-tPA) could differentially control the effects of tPA on neuronal survival. Using primary cultures of mouse cortical neurons, our present study reveals that sc-tPA is the only one capable to promote N-methyl-D-aspartate receptor (NMDAR)-induced calcium influx and subsequent excitotoxicity. In contrast, both sc-tPA and tc-tPA are capable to activate epidermal growth factor receptors (EGFRs), a mechanism mediating the antiapoptotic effects of tPA. Interestingly, we revealed a tPA dependent crosstalk between EGFR and NMDAR in which a tPA-dependent activation of EGFRs leads to downregulation of NMDAR signaling and to subsequent neurotrophic effects. PMID:26469972

  18. Removal of damaged proteins during ES cell fate specification requires the proteasome activator PA28

    PubMed Central

    Hernebring, Malin; Fredriksson, Åsa; Liljevald, Maria; Cvijovic, Marija; Norrman, Karin; Wiseman, John; Semb, Henrik; Nyström, Thomas

    2013-01-01

    In embryonic stem cells, removal of oxidatively damaged proteins is triggered upon the first signs of cell fate specification but the underlying mechanism is not known. Here, we report that this phase of differentiation encompasses an unexpected induction of genes encoding the proteasome activator PA28αβ (11S), subunits of the immunoproteasome (20Si), and the 20Si regulator TNFα. This induction is accompanied by assembly of mature PA28-20S(i) proteasomes and elevated proteasome activity. Inhibiting accumulation of PA28α using miRNA counteracted the removal of damaged proteins demonstrating that PA28αβ has a hitherto unidentified role required for resetting the levels of protein damage at the transition from self-renewal to cell differentiation. PMID:23459332

  19. Impacts of tissue-type plasminogen activator (tPA) on neuronal survival

    PubMed Central

    Chevilley, Arnaud; Lesept, Flavie; Lenoir, Sophie; Ali, Carine; Parcq, Jérôme; Vivien, Denis

    2015-01-01

    Tissue-type plasminogen activator (tPA) a serine protease is constituted of five functional domains through which it interacts with different substrates, binding proteins, and receptors. In the last years, great interest has been given to the clinical relevance of targeting tPA in different diseases of the central nervous system, in particular stroke. Among its reported functions in the central nervous system, tPA displays both neurotrophic and neurotoxic effects. How can the protease mediate such opposite functions remain unclear but several hypotheses have been proposed. These include an influence of the degree of maturity and/or the type of neurons, of the level of tPA, of its origin (endogenous or exogenous) or of its form (single chain tPA versus two chain tPA). In this review, we will provide a synthetic snapshot of our current knowledge regarding the natural history of tPA and discuss how it sustains its pleiotropic functions with focus on excitotoxic/ischemic neuronal death and neuronal survival. PMID:26528141

  20. Interaction of human tissue plasminogen activator (t-PA) with pregnancy zone protein: a comparative study with t-PA-alpha2-macroglobulin interaction.

    PubMed

    Sánchez, M C; Chiabrando, G A; Guglielmone, H A; Bonacci, G R; Rabinovich, G A; Vides, M A

    1998-08-01

    Human pregnancy zone protein (PZP) is a major pregnancy-associated plasma protein strongly related to alpha2-macroglobulin (alpha2-M). Interactions of tissue plasminogen activator (t-PA) with PZP and alpha2-M were both investigated in vitro and the complexes were analyzed by polyacrylamide gel electrophoresis (PAGE). The results demonstrated that PZP-t-PA complex formation was evident within 1 h of incubation, whereas alpha2-M-t-PA complexes were formed after 18 h. Conclusions were supported by the following evidence: (i) PZP and alpha2-M complexes revealed changes of the mobility rate in non-denaturing PAGE, similar to those observed with alpha-Ms-chymotrypsin; (ii) both PZP and alpha2-M formed complexes of molecular size >360 kDa by SDS-PAGE, in accordance with the covalent binding of t-PA, which was previously reported for other proteinases; and (iii) PZP underwent a specific cleavage of the bait region with appearence of fragments of 85-90 kDa as judged by reducing SDS-PAGE. In contrast, the proteolytic attack on alpha2-M was found to occur more slowly, requiring several hours of incubation with t-PA for generation of an appreciable amount of fragments of 85-90 kDa. The appearance of free SH-groups of alpha-Ms was further investigated by titration with 5, 5'-dithiobis(2-nitrobenzoic acid). The maximal level of SH-groups raised was 3.9 mol/mol of PZP and 3.5 mol/mol of alpha2-M, indicating approximately one SH-group for each 180-kDa subunit. Finally, t-PA activity in PZP-t-PA complex was evaluated by measuring the hydrolysis of the chromogenic substrate Flavigen t-PA. Our results revealed that prolongation of the incubation period of this complex increased t-PA-mediated hydrolysis of Flavigen t-PA until a plateau was reached, approximately between 60 and 120 min. The present study suggests that PZP, by binding to t-PA, may contribute to the control of the activity of proteinases derived from fibrinolytic systems.

  1. Physical Activity Participation of Disabled Children: A Systematic Review of Conceptual and Methodological Approaches in Health Research

    PubMed Central

    Ross, Samantha Mae; Bogart, Kathleen R.; Logan, Samuel W.; Case, Layne; Fine, Jeremiah; Thompson, Hanna

    2016-01-01

    Physical activity (PA) participation is widely recognized as a critical component of health and development for disabled and non-disabled children. Emergent literature reflects a paradigm shift in the conceptualization of childhood PA as a multi-dimensional construct, encompassing aspects of physical performance, and self-perceived engagement. However, ambiguity remains around how participation as a health construct is integrated into PA research. The primary objective of the present mini-review is to critically examine current conceptual and methodological approaches to evaluating PA participation among disabled children. We conducted a systematic review of contemporary literature (published between 2000 and 2016). Seventeen articles met inclusion criteria, and their research approach was classified into guiding framework, definition of the key construct, and measurement used. The primary guiding framework was the international classification of functioning, disability and health. An explicit definition of PA participation was absent from all studies. Eight studies (47%) operationalized PA and participation as independent constructs. Measurements included traditional performance-based aspects of PA (frequency, duration, and intensity), and alternative participation measures (subjective perception of involvement, inclusion, or enjoyment). Approximately 64% of included articles were published in the past 2 years (2014–2016) indicating a rising interest in the topic of PA participation. Drawing from the broader discussion of participation in the literature, we offer a working definition of PA participation as it pertains to active, health-associated behaviors. Further description of alternative approaches to framing and measuring PA participation are offered to support effective assessment of health status among disabled children. PMID:27656639

  2. Physical Activity Participation of Disabled Children: A Systematic Review of Conceptual and Methodological Approaches in Health Research.

    PubMed

    Ross, Samantha Mae; Bogart, Kathleen R; Logan, Samuel W; Case, Layne; Fine, Jeremiah; Thompson, Hanna

    2016-01-01

    Physical activity (PA) participation is widely recognized as a critical component of health and development for disabled and non-disabled children. Emergent literature reflects a paradigm shift in the conceptualization of childhood PA as a multi-dimensional construct, encompassing aspects of physical performance, and self-perceived engagement. However, ambiguity remains around how participation as a health construct is integrated into PA research. The primary objective of the present mini-review is to critically examine current conceptual and methodological approaches to evaluating PA participation among disabled children. We conducted a systematic review of contemporary literature (published between 2000 and 2016). Seventeen articles met inclusion criteria, and their research approach was classified into guiding framework, definition of the key construct, and measurement used. The primary guiding framework was the international classification of functioning, disability and health. An explicit definition of PA participation was absent from all studies. Eight studies (47%) operationalized PA and participation as independent constructs. Measurements included traditional performance-based aspects of PA (frequency, duration, and intensity), and alternative participation measures (subjective perception of involvement, inclusion, or enjoyment). Approximately 64% of included articles were published in the past 2 years (2014-2016) indicating a rising interest in the topic of PA participation. Drawing from the broader discussion of participation in the literature, we offer a working definition of PA participation as it pertains to active, health-associated behaviors. Further description of alternative approaches to framing and measuring PA participation are offered to support effective assessment of health status among disabled children. PMID:27656639

  3. Physical Activity Participation of Disabled Children: A Systematic Review of Conceptual and Methodological Approaches in Health Research

    PubMed Central

    Ross, Samantha Mae; Bogart, Kathleen R.; Logan, Samuel W.; Case, Layne; Fine, Jeremiah; Thompson, Hanna

    2016-01-01

    Physical activity (PA) participation is widely recognized as a critical component of health and development for disabled and non-disabled children. Emergent literature reflects a paradigm shift in the conceptualization of childhood PA as a multi-dimensional construct, encompassing aspects of physical performance, and self-perceived engagement. However, ambiguity remains around how participation as a health construct is integrated into PA research. The primary objective of the present mini-review is to critically examine current conceptual and methodological approaches to evaluating PA participation among disabled children. We conducted a systematic review of contemporary literature (published between 2000 and 2016). Seventeen articles met inclusion criteria, and their research approach was classified into guiding framework, definition of the key construct, and measurement used. The primary guiding framework was the international classification of functioning, disability and health. An explicit definition of PA participation was absent from all studies. Eight studies (47%) operationalized PA and participation as independent constructs. Measurements included traditional performance-based aspects of PA (frequency, duration, and intensity), and alternative participation measures (subjective perception of involvement, inclusion, or enjoyment). Approximately 64% of included articles were published in the past 2 years (2014–2016) indicating a rising interest in the topic of PA participation. Drawing from the broader discussion of participation in the literature, we offer a working definition of PA participation as it pertains to active, health-associated behaviors. Further description of alternative approaches to framing and measuring PA participation are offered to support effective assessment of health status among disabled children.

  4. Physical Activity Participation and Preferences: Developmental and Oncology-Related Transitions in Adolescents Treated for Cancer

    PubMed Central

    2015-01-01

    ABSTRACT Purpose: To describe motor function and participation in, barriers to, and preferences for physical activity (PA) in adolescents during and after treatment of cancer and to discuss PA promotion in the context of developmental and cancer transitions. Method: A cross-sectional survey study used the Transfer and Basic Mobility and Sports/Physical Functioning self-report and parent-report scales of the Pediatric Outcomes Data Collection Instrument (PODCI) and questions about PA participation and preferences to collect information from 80 adolescents and 63 parents. Results: PODCI scores for adolescents receiving treatment were more variable and significantly lower than those of adolescents who had been off treatment for more than 2 years. Fatigue, pain, general health, and doctor's orders were frequently identified as barriers to PA for adolescents receiving treatment. Many did not achieve recommended levels of PA. The adolescents expressed preferences for being active with friends and family, at home or in school, in the afternoon or evening, and through daily recreational and sports activities typical of teenagers. Conclusions: Physical abilities and participation in and barriers to PA vary across the cancer journey. Interventions should be sensitive to variability and acknowledge individual preferences and environments throughout the trajectories and transitions of cancer treatment and youth development to achieve lifelong healthy lifestyles. PMID:26839461

  5. Self-Regulated Learning and Perceived Health among University Students Participating in Physical Activity Classes

    ERIC Educational Resources Information Center

    McBride, Ron E.; Altunsöz, Irmak Hürmeriç; Su, Xiaoxia; Xiang, Ping; Demirhan, Giyasettin

    2016-01-01

    The purpose of this study was to explore motivational indicators of self-regulated learning (SRL) and the relationship between self-regulation (SR) and perceived health among university students enrolled in physical activity (PA) classes. One hundred thirty-one Turkish students participating in physical education activity classes at two…

  6. Microglia and the urokinase plasminogen activator receptor/uPA system in innate brain inflammation.

    PubMed

    Cunningham, Orla; Campion, Suzanne; Perry, V Hugh; Murray, Carol; Sidenius, Nicolai; Docagne, Fabian; Cunningham, Colm

    2009-12-01

    The urokinase plasminogen activator (uPA) receptor (uPAR) is a GPI-linked cell surface protein that facilitates focused plasmin proteolytic activity at the cell surface. uPAR has been detected in macrophages infiltrating the central nervous system (CNS) and soluble uPAR has been detected in the cerebrospinal fluid during a number of CNS pathologies. However, its expression by resident microglial cells in vivo remains uncertain. In this work, we aimed to elucidate the murine CNS expression of uPAR and uPA as well as that of tissue plasminogen activator and plasminogen activator inhibitor 1 (PAI-1) during insults generating distinct and well-characterized inflammatory responses; acute intracerebral lipopolysaccharide (LPS), acute kainate-induced neurodegeneration, and chronic neurodegeneration induced by prion disease inoculation. All three insults induced marked expression of uPAR at both mRNA and protein level compared to controls (naïve, saline, or control inoculum-injected). uPAR expression was microglial in all cases. Conversely, uPA transcription and activity was only markedly increased during chronic neurodegeneration. Dissociation of uPA and uPAR levels in acute challenges is suggestive of additional proteolysis-independent roles for uPAR. PAI-1 was most highly expressed upon LPS challenge, whereas tissue plasminogen activator mRNA was constitutively present and less responsive to all insults studied. These data are novel and suggest much wider involvement of the uPAR/uPA system in CNS function and pathology than previously supposed. PMID:19459212

  7. Microglia and the urokinase plasminogen activator receptor/uPA system in innate brain inflammation.

    PubMed

    Cunningham, Orla; Campion, Suzanne; Perry, V Hugh; Murray, Carol; Sidenius, Nicolai; Docagne, Fabian; Cunningham, Colm

    2009-12-01

    The urokinase plasminogen activator (uPA) receptor (uPAR) is a GPI-linked cell surface protein that facilitates focused plasmin proteolytic activity at the cell surface. uPAR has been detected in macrophages infiltrating the central nervous system (CNS) and soluble uPAR has been detected in the cerebrospinal fluid during a number of CNS pathologies. However, its expression by resident microglial cells in vivo remains uncertain. In this work, we aimed to elucidate the murine CNS expression of uPAR and uPA as well as that of tissue plasminogen activator and plasminogen activator inhibitor 1 (PAI-1) during insults generating distinct and well-characterized inflammatory responses; acute intracerebral lipopolysaccharide (LPS), acute kainate-induced neurodegeneration, and chronic neurodegeneration induced by prion disease inoculation. All three insults induced marked expression of uPAR at both mRNA and protein level compared to controls (naïve, saline, or control inoculum-injected). uPAR expression was microglial in all cases. Conversely, uPA transcription and activity was only markedly increased during chronic neurodegeneration. Dissociation of uPA and uPAR levels in acute challenges is suggestive of additional proteolysis-independent roles for uPAR. PAI-1 was most highly expressed upon LPS challenge, whereas tissue plasminogen activator mRNA was constitutively present and less responsive to all insults studied. These data are novel and suggest much wider involvement of the uPAR/uPA system in CNS function and pathology than previously supposed.

  8. Development through Participation in Sociocultural Activity.

    ERIC Educational Resources Information Center

    Rogoff, Barbara; And Others

    1995-01-01

    Presents the theoretical position that as people participate in sociocultural activities, they contribute to the development of community practices that simultaneously contribute to the individuals' own development. Illustrates this argument using observations of the developmental processes of individual Girl Scouts and of community traditions of…

  9. Dcsbis (PA2771) from Pseudomonas aeruginosa is a highly active diguanylate cyclase with unique activity regulation

    PubMed Central

    Chen, Ying; Liu, Shiheng; Liu, Cuilan; Huang, Yan; Chi, Kaikai; Su, Tiantian; Zhu, Deyu; Peng, Jin; Xia, Zhijie; He, Jing; Xu, Sujuan; Hu, Wei; Gu, Lichuan

    2016-01-01

    C-di-GMP (3’,5’ -Cyclic diguanylic acid) is an important second messenger in bacteria that influences virulence, motility, biofilm formation, and cell division. The level of c-di-GMP in cells is controlled by diguanyl cyclases (DGCs) and phosphodiesterases (PDEs). Here, we report the biochemical functions and crystal structure of the potential diguanylase Dcsbis (PA2771, a diguanylate cyclase with a self-blocked I-site) from Pseudomonas aeruginosa PAO1. The full-length Dcsbis protein contains an N-terminal GAF domain and a C-terminal GGDEF domain. We showed that Dcsbis tightly coordinates cell motility without markedly affecting biofilm formation and is a diguanylate cyclase with a catalytic activity much higher than those of many other DGCs. Unexpectedly, we found that a peptide loop (protecting loop) extending from the GAF domain occupies the conserved inhibition site, thereby largely relieving the product-inhibition effect. A large hydrophobic pocket was observed in the GAF domain, thus suggesting that an unknown upstream signaling molecule may bind to the GAF domain, moving the protecting loop from the I-site and thereby turning off the enzymatic activity. PMID:27388857

  10. EuPA achieves visibility - an activity report on the first three years.

    PubMed

    Dunn, M J; Gil, C; Kleinhammer, C; Lottspeich, F; Pennington, S; Sanchez, J-Ch; Albar, J P; Bini, L; Corrales, F; Corthals, G L; Fountoulakis, M M; Hoogland, C; James, P; Jensen, O N; Jiménez, C; Jorrín-Novo, J; Kraus, H-J; Meyer, H; Noukakis, D; Palagi, P M; Penque, D; Quinn, A; Rabilloud, T

    2008-04-30

    Plans for the European Proteomics Association (EuPA) were conceived and established during 2004 and 2005, and culminated in the formal inception of the organisation during the 4th HUPO World Congress held in Munich in 2005. The mission from the outset has been three-tiered and is to: i) strengthen the national Proteomics organizations in their efforts; ii) to co-ordinate and provide educational programs, and iii) to advance the networking of scientists through meetings, workshops and student exchange. Linked to the mission were objectives to emphasise the benefits and contributions of Proteomics to biological and industrial researchers, the general public and science policy makers in Europe. In addition, the EuPA set out to promote scientific exchange for all applications and technology development related to Proteomics, and coordinate joint activities of national Proteomics societies at the European level. To achieve these tasks an organisational structure was conceived whereby four Activity Committees (Conferences/Communications, Education, EuPA-HUPO-Interactions and Funding) were implemented and a General Council consisting of all member countries. The remarkable rise and progress the EuPA has achieved in this small time frame is reported here.

  11. Pyruvate and cilostazol protect cultured rat cortical pericytes against tissue plasminogen activator (tPA)-induced cell death.

    PubMed

    Kim, Ha Na; Kim, Tae-Youn; Yoon, Young Hee; Koh, Jae-Young

    2015-12-01

    Since even a brief ischemia can cause permanent brain damage, rapid restoration of blood flow is critical to limiting damage. Although intravenous tPA during the acute stage is the treatment of choice for achieving reperfusion, this treatment is sometimes associated with brain hemorrhage. Agents that reduce tPA-related bleeding risk may help expand its therapeutic window. This study assessed whether zinc dyshomeostasis underlies the toxic effect of tPA on brain vascular pericytes; whether pyruvate, an inhibitor of zinc toxicity, protects pericytes against tPA-induced cell death; and whether cilostazol, which protects pericytes against tPA-induced cell death, affects zinc dyshomeostasis associated with tPA toxicity. Cultured pericytes from newborn rat brains were treated with 10-200 μg/ml tPA for 24 h, inducing cell death in a concentration-dependent manner. tPA-induced cell death was preceded by increases in intracellular free zinc levels, and was substantially attenuated by plasminogen activator inhibitor-1 (PAI-1) or TPEN. Pyruvate completely blocked direct zinc toxicity and tPA-induced pericyte cell death. Both cAMP and cilostazol, a PDE3 inhibitor that attenuates tPA-induced pericyte cell death in vitro and tPA-induced brain hemorrhage in vivo, reduced zinc- and tPA-induced pericyte cell death, suggesting that zinc dyshomeostasis may be targeted by cilostazol in tPA toxicity. These findings show that tPA-induced pericyte cell death may involve zinc dyshomeostasis, and that pyruvate and cilostazol attenuate tPA-induced cell death by reducing the toxic cascade triggered by zinc dyshomeostasis. Since pyruvate is an endogenous metabolite and cilostazol is an FDA-approved drug, in vivo testing of both as protectors against tPA-induced brain hemorrhage may be warranted. This article is part of a Special Issue entitled SI: Neuroprotection.

  12. 26 CFR 1.219-2 - Definition of active participant.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 3 2010-04-01 2010-04-01 false Definition of active participant. 1.219-2... active participant. (a) In general. This section defines the term active participant for individuals who participate in retirement plans described in section 219(b)(2). Any individual who is an active participant...

  13. Participation in Physical Activity among Normal- and Overweight Hispanic and Non-Hispanic White Adolescents

    ERIC Educational Resources Information Center

    Stovitz, Steven D.; Steffen, Lyn M.; Boostrom, Ardys

    2008-01-01

    Background: The purpose of this study was to determine the relation between weight status and participation in physical activity (PA) among Hispanic and non-Hispanic white (NHW) adolescent boys and girls. Methods: In this cross-sectional study, height and weight were measured and a modified 2001 Youth Risk Behavior Survey was administered to 1302…

  14. Transition in Participation in Sport and Unstructured Physical Activity for Rural Living Adolescent Girls

    ERIC Educational Resources Information Center

    Eime, R. M.; Payne, W. R.; Casey, M. M.; Harvey, J. T.

    2010-01-01

    Physical activity (PA) is important for lifelong health; however, participation is lower in rural compared with metropolitan areas and declines during adolescence, particularly for girls. It is likely that this decline is related to the number of life transitions that occur during adolescence. This qualitative study examined the views of active…

  15. 29 CFR 4043.23 - Active participant reduction.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 9 2011-07-01 2011-07-01 false Active participant reduction. 4043.23 Section 4043.23 Labor... Active participant reduction. (a) Reportable event. A reportable event occurs when the number of active participants under a plan is reduced to less than 80 percent of the number of active participants at...

  16. 26 CFR 1.219-2 - Definition of active participant.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 3 2012-04-01 2012-04-01 false Definition of active participant. 1.219-2... Definition of active participant. (a) In general. This section defines the term active participant for... active participant in such a plan is not allowed a deduction under section 219(a) for contributions to...

  17. 29 CFR 4043.23 - Active participant reduction.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 9 2014-07-01 2014-07-01 false Active participant reduction. 4043.23 Section 4043.23 Labor... Active participant reduction. (a) Reportable event. A reportable event occurs when the number of active participants under a plan is reduced to less than 80 percent of the number of active participants at...

  18. 26 CFR 1.219-2 - Definition of active participant.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 3 2013-04-01 2013-04-01 false Definition of active participant. 1.219-2... Definition of active participant. (a) In general. This section defines the term active participant for... active participant in such a plan is not allowed a deduction under section 219(a) for contributions to...

  19. 26 CFR 1.219-2 - Definition of active participant.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 3 2014-04-01 2014-04-01 false Definition of active participant. 1.219-2... Definition of active participant. (a) In general. This section defines the term active participant for... active participant in such a plan is not allowed a deduction under section 219(a) for contributions to...

  20. Involvement of tissue plasminogen activator "tPA" in ethanol-induced locomotor sensitization and conditioned-place preference.

    PubMed

    Bahi, Amine; Dreyer, Jean-Luc

    2012-01-01

    Ethanol is one of the most abused drugs in the western societies. It is well established that mesolimbic dopaminergic neurons mediate the rewarding properties of ethanol. In our previous studies we have shown that the serine protease tissue plasminogen activator (tPA) is involved in the rewarding properties of morphine and amphetamine. In the current study, we investigated the role of tPA in ethanol-induced behavioral sensitization and conditioned-place preference (CPP). Ethanol treatment dose-dependently induced tPA enzymatic activity in the nucleus accumbens (NAc). In addition, ethanol-induced increase in tPA activity was completely inhibited by pre-treatment with the dopamine D1 and D2 receptor antagonists SCH23390 and raclopride respectively. Furthermore, ethanol-induced locomotor stimulation, behavioral sensitization and conditioned-place preference were enhanced following tPA over-expression in the NAc using a lentiviral vector. In contrast, tPA knock down in the NAc with specific shRNA blocked the rewarding properties of ethanol. The defect of locomotor stimulation in shRNA-injected mice was reversed by microinjections of exogenous recombinant tPA into the nucleus accumbens. Collectively, these results indicate, for the first time, that activation of tPA is effective in enhancing the rewarding effects of ethanol. Targeting the tissue plasminogen activator system would provide new therapeutic approaches to the treatment of alcoholism.

  1. Effect of Electronic Messaging on Physical Activity Participation among Older Adults

    PubMed Central

    Antoine Parker, Chantrell; Ellis, Rebecca

    2016-01-01

    The purpose of this study was to determine if electronic messaging would increase min of aerobic physical activity (PA) among older adults. Participants were active older adults (n = 28; M age = 60 years, SD = 5.99, and range = 51–74 years). Using an incomplete within-subjects crossover design, participants were randomly assigned to begin the 4-week study receiving the treatment condition (a morning and evening text message) or the control condition (an evening text message). Participants self-reported min of completed aerobic PA by cell phone text. The 1-way within-subjects ANOVA showed significant group differences (p < 0.05). Specifically, when participants were in the treatment condition, they reported significantly greater average weekly min of aerobic PA (M = 96.88 min, SD = 62.9) compared to when they completed the control condition (M = 71.68 min, SD = 40.98). Electronic messaging delivered via cell phones was effective at increasing min of aerobic PA among older adults. PMID:27293891

  2. Expression and Biological Activity of the Cystine Knot Bioinsecticide PA1b (Pea Albumin 1 Subunit b)

    PubMed Central

    Eyraud, Vanessa; Karaki, Lamis; Rahioui, Isabelle; Sivignon, Catherine; Da Silva, Pedro; Rahbé, Yvan; Royer, Corinne; Gressent, Frédéric

    2013-01-01

    The PA1b (Pea Albumin 1, subunit b) peptide is an entomotoxin extract from Legume seeds with lethal activity on several insect pests, such as mosquitoes, some aphids and cereal weevils. This 37 amino-acid cysteine-rich peptide has been, until now, obtained by biochemical purification or chemical synthesis. In this paper, we present our results for the transient production of the peptide in Nicotiana benthamiana by agro-infiltration, with a yield of about 35 µg/g of fresh leaves and maximum production 8 days after infiltration. PA1b is part of the PA1 gene which, after post-translational modifications, encodes two peptides (PA1b and PA1a). We show that transforming tobacco with the PA1b cDNA alone does not result in production of the toxin and, in fact, the entire cDNA is necessary, raising the question of the role of PA1a. We constructed a PA1-cassette, allowing for the quick “cut/paste” of different PA1b mutants within a conserved PA1 cDNA. This cassette enabled us to produce the six isoforms of PA1b which exist in pea seeds. Biological tests revealed that all the isoforms display similar activity, with the exception of one which is inactive. The lack of activity in this isoform led us to conclude that the amphiphilic nature of the peptide is necessary for activity. The possible applications of this expression system for other cysteine-rich biomolecules are discussed. PMID:24349099

  3. STS-87 crew participate in TCDT activities

    NASA Technical Reports Server (NTRS)

    1997-01-01

    The crew of the STS-87 mission, scheduled for launch Nov. 19 aboard the Space Shuttle Columbia from Pad 39B at Kennedy Space Center (KSC), participates in the Terminal Countdown Demonstration Test (TCDT) at KSC. Getting a look at the Space Shuttle Columbia are, from left, Commander Kevin Kregel; Pilot Steven Lindsey; Mission Specialist Kalpana Chawla, Ph.D.; Payload Specialist Leonid Kadenyuk of the National Space Agency of Ukraine (NSAU); Mission Specialist Takao Doi, Ph.D., of the National Space Development Agency of Japan; Kadenyuks back-up, Yaroslav Pustovyi, Ph.D., also of NSAU; and Mission Specialist Winston Scott. The TCDT is held at KSC prior to each Space Shuttle flight providing the crew of each mission opportunities to participate in simulated countdown activities. The TCDT ends with a mock launch countdown culminating in a simulated main engine cut-off. The crew also spends time undergoing emergency egress training exercises at the pad and has an opportunity to view and inspect the payloads in the orbiter's payload bay.

  4. Reciprocal actions of NCAM and tPA via a Ras-dependent MAPK activation in rat hippocampal neurons.

    PubMed

    Son, Hyeon; Seuk Kim, Jin; Mogg Kim, Jung; Lee, Sang-Hun; Lee, Yong-Sung

    2002-10-25

    In an attempt to identify the functions of neural cell adhesion molecule (NCAM) and tissue plasminogen activator (tPA) in hippocampal synaptic plasticity, we investigated the relationship between the two molecules by focusing on mitogen-activated protein kinase (MAPK), an essential enzyme in this process. NCAM clustering in cultured hippocampal neurons transiently induced MAPK within 10min. Moreover, soluble NCAM also induced a Ras-dependent MAPK activation. Conversely, MAPK activation led to an increase in the expressions of all three isoforms of NCAM. Treatment of neurons with tPA and plasminogen induced a Ras-dependent MAPK activation and tPA-plasmin degradation of NCAM was mediated in a MAPK-dependent manner. Soluble NCAM transiently inhibited tPA mRNA expression levels in a MAPK-dependent manner, while stimulation of MAPK alone induced tPA reduction in cells. These results collectively indicate that NCAM and tPA reciprocally act as important regulators in the modulation of synaptic plasticity via a Ras-MAPK-involved signaling pathway. In turn, MAPK activation may cause tPA degradation or a decrease in expression to promote synaptic plasticity.

  5. Dopamine D3 receptor deletion increases tissue plasminogen activator (tPA) activity in prefrontal cortex and hippocampus.

    PubMed

    Castorina, A; D'Amico, A G; Scuderi, S; Leggio, G M; Drago, F; D'Agata, V

    2013-10-10

    Considerable evidence indicates that dopamine (DA) influences tissue plasminogen activator (tPA)-mediated proteolytic processing of the precursor of brain-derived neurotrophic factor (proBDNF) into mature BDNF (mBDNF). However, specific roles in this process for the dopamine D3 receptor (D3R) and the underlying molecular mechanisms are yet to be fully characterized. In the present study, we hypothesized that D3R deletion could influence tPA activity in the prefrontal cortex and hippocampus. Using D3R knockout (D3(-/-)) mice, we show that receptor inactivation is associated with increased tPA expression/activity both in the prefrontal cortex and, to a greater extent, in the hippocampus. Augmented tPA expression in D3(-/-) mice correlated with increased BDNF mRNA levels, plasmin/plasminogen protein ratio and the conversion of proBDNF into mBDNF, as well as enhanced tPA and mBDNF immunoreactivity, as determined by quantitative real time polymerase chain reaction (qRT-PCR), immunoblot and immunohistochemistry. In addition, when compared to wild-type controls, D3(-/-) mice exhibited increased basal activation of the canonical cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA)-driven Akt/cAMP-response element-binding protein (CREB) signaling cascade, as determined by the increased Akt phosphorylation both at Thr304 and Ser473 residues, of DA and cAMP-regulated protein of 32kDa (DARPP-32) at Thr34 and a phosphorylation state-dependent inhibition of glycogen synthetase kinase-3β (GSK-3β) at Ser9, a substrate of Akt whose constitutive function impairs normal CREB transcriptional activity through phosphorylation at its Ser129 residue. Accordingly, CREB phosphorylation at Ser133 was significantly increased in D3(-/-) mice, whereas the GSK-3β-dependent phosphorylation at Ser129 was diminished. Altogether, our finding reveals that mice lacking D3Rs show enhanced tPA proteolytic activity on BDNF which may involve, at least in part, a potentiated Akt/CREB signaling

  6. Mapping of a Region of the PA-X Protein of Influenza A Virus That Is Important for Its Shutoff Activity.

    PubMed

    Oishi, Kohei; Yamayoshi, Seiya; Kawaoka, Yoshihiro

    2015-08-01

    Influenza A virus PA-X comprises an N-terminal PA endonuclease domain and a C-terminal PA-X-specific domain. PA-X reduces host and viral mRNA accumulation via its endonuclease function. Here, we found that the N-terminal 15 amino acids, particularly six basic amino acids, in the C-terminal PA-X-specific region are important for PA-X shutoff activity. These six basic amino acids enabled a PA deletion mutant to suppress protein expression at a level comparable to that of wild-type PA-X.

  7. Structural details of light activation of the LOV2-based photoswitch PA-Rac1.

    PubMed

    Winkler, Andreas; Barends, Thomas R M; Udvarhelyi, Anikó; Lenherr-Frey, Daniel; Lomb, Lukas; Menzel, Andreas; Schlichting, Ilme

    2015-02-20

    Optical control of cellular processes is an emerging approach for studying biological systems, affording control with high spatial and temporal resolution. Specifically designed artificial photoswitches add an interesting extension to naturally occurring light-regulated functionalities. However, despite a great deal of structural information, the generation of new tools cannot be based fully on rational design yet; in many cases design is limited by our understanding of molecular details of light activation and signal transduction. Our biochemical and biophysical studies on the established optogenetic tool PA-Rac1, the photoactivatable small GTPase Rac1, reveal how unexpected details of the sensor-effector interface, such as metal coordination, significantly affect functionally important structural elements of this photoswitch. Together with solution scattering experiments, our results favor differences in the population of pre-existing conformations as the underlying allosteric activation mechanism of PA-Rac1, rather than the assumed release of the Rac1 domain from the caging photoreceptor domain. These results have implications for the design of new optogenetic tools and highlight the importance of including molecular details of the sensor-effector interface, which is however difficult to assess during the initial design of novel artificial photoswitches.

  8. Psychological Correlates of Self-Reported and Objectively Measured Physical Activity among Chinese Children—Psychological Correlates of PA

    PubMed Central

    Wang, Jing-Jing; Baranowski, Tom; Lau, Patrick W. C.; Chen, Tzu-An; Zhang, Shu-Ge

    2016-01-01

    This study aimed to explore the associations among psychological correlates and physical activity (PA) in Chinese children and to further examine whether these associations varied by different PA measures. PA self-efficacy, motivation, and preference were reported in 449 8–13-year-old Chinese children (252 males). Moderate- to vigorous- intensity PA (MVPA) was measured by the Physical Activity Questionnaire for Older Children (PAQ-C) and with an ActiGraph GT3X accelerometer. Correlations and hierarchical regressions were performed to explore their associations. The study psychological variables were all positively related to PAQ-C and objective MVPA (r: 0.22–0.63). The associations with PAQ-C were all substantially stronger than those with accelerometry. Beyond the explained variance accounted for by demographics and social desirability, the addition of the psychological correlates accounted for 45% of the variance of the PAQ-C score, while only 13% for accelerometry-based MVPA. The associations of specific variables with the PAQ-C score (age, PA self-efficacy, autonomous motivation and preference) were somewhat different from those associated with objective MVPA (PA self-efficacy, autonomous motivation, and negatively associated with female gender). This study demonstrated the importance of self-efficacy and autonomous motivation in association with PA and indicated the difference in level of their associations with different PA measures. PMID:27754396

  9. Specific interaction of tissue-type plasminogen activator (t-PA) with annexin II on the membrane of pancreatic cancer cells activates plasminogen and promotes invasion in vitro

    PubMed Central

    Díaz, V M; Hurtado, M; Thomson, T M; Reventós, J; Paciucci, R

    2004-01-01

    Background: Overexpression of tissue plasminogen activator (t-PA) in pancreatic cancer cells promotes invasion and proliferation in vitro and tumour growth and angiogenesis in vivo. Aims: To understand the mechanisms by which t-PA favours cancer progression, we analysed the surface membrane proteins responsible for binding specifically t-PA and studied the contribution of this interaction to the t-PA promoted invasion of pancreatic cancer cells. Methods: The ability of t-PA to activate plasmin and a fluorogenic plasmin substrate was used to analyse the nature of the binding of active t-PA to cell surfaces. Specific binding was determined in two pancreatic cancer cell lines (SK-PC-1 and PANC-1), and complex formation analysed by co-immunoprecipitation experiments and co-immunolocalisation in tumours. The functional role of the interaction was studied in Matrigel invasion assays. Results: t-PA bound to PANC-1 and SK-PC-1 cells in a specific and saturable manner while maintaining its activity. This binding was competitively inhibited by specific peptides interfering with the interaction of t-PA with annexin II. The t-PA/annexin II interaction on pancreatic cancer cells was also supported by co-immunoprecipitation assays using anti-t-PA antibodies and, reciprocally, with antiannexin II antibodies. In addition, confocal microscopy showed t-PA and annexin II colocalisation in tumour tissues. Finally, disruption of the t-PA/annexin II interaction by a specific hexapeptide significantly decreased the invasive capacity of SK-PC-1 cells in vitro. Conclusion: t-PA specifically binds to annexin II on the extracellular membrane of pancreatic cancer cells where it activates local plasmin production and tumour cell invasion. These findings may be clinically relevant for future therapeutic strategies based on specific drugs that counteract the activity of t-PA or its receptor annexin II, or their interaction at the surface level. PMID:15194650

  10. Leisure Activity Participation of Elderly Individuals with Low Vision.

    ERIC Educational Resources Information Center

    Heinemann, Allen W.

    1988-01-01

    Studied low vision elderly clinic patients (N=63) who reported participation in six categories of leisure activities currently and at onset of vision loss. Found subjects reported significant declines in five of six activity categories. Found prior activity participation was related to current participation only for active crafts, participatory…

  11. An effort to 'leverage' the effect of participation in a mass event on physical activity.

    PubMed

    Lane, Aoife; Murphy, Niamh; Bauman, Adrian

    2015-09-01

    Despite the considerable interest in community-based physical activity (PA) interventions, there is a lack of clarity on which strategies are most effective and most likely to work in different contexts. The purpose of this study was to use existing community resources to promote PA in a population sample of insufficiently active women using a cluster RCT design. Participants (n = 402) were grouped into 32 geographical-based clusters, which were randomly allocated into 16 intervention (n = 193) and 16 control (n = 209) regions. The intervention was delivered in conjunction with regional units of the Irish Sports Council; participants received a pack containing tailored information about local PA options in their community, training plans, stage-matched behaviour change booklets and a pedometer. Control participants received health promotion leaflets. Evaluation was conducted using the RE-AIM framework to assess both effectiveness and generalizability. Repeated measures ANOVAs with adjustment for clustering revealed that both groups displayed an approximate 39 min increase in PA, but decreases in sitting were greater in the intervention group than the control group (32.9 versus 1.2 min). Recall of materials was high ranging between 85 and 97% for the various intervention components. Finally, those who received higher doses of the intervention (three or more components) reported an approximate 50 min increase in PA compared with 18 min among those who did not use any aspect of the intervention. While no clear intervention effect was evident, this research was successful in linking and implementing good research design with PA promoting networks.

  12. Oxidation of gas-phase protactinium ions, Pa+ and Pa2+: formation and properties of PaO2(2+)(g), protactinyl.

    PubMed

    Santos, Marta; de Matos, António Pires; Marçalo, Joaquim; Gibson, John K; Haire, Richard G; Tyagi, Rajni; Pitzer, Russell M

    2006-05-01

    Oxidation reactions of bare and ligated, monopositive, and dipositive Pa ions in the gas phase were studied by Fourier transform ion cyclotron resonance mass spectrometry. Seven oxidants were employed, ranging from the thermodynamically robust N(2)O to the relatively weak CH(2)O-all oxidized Pa(+) to PaO(+) and PaO(+) to PaO(2)(+). On the basis of experimental observations, it was established that D[Pa(+)-O] and D[OPa(+)-O] > or = 751 kJ mol(-1). Estimates for D[Pa(+)-O], D[OPa(+)-O], IE[PaO], and IE[PaO(2)] were also obtained. The seven oxidants reacted with Pa(2+) to produce PaO(2+), indicating that D[Pa(2+)-O] > or = 751 kJ mol(-1). A particularly notable finding was the oxidation of PaO(2+) by N(2)O to PaO(2)(2+), a species, which formally comprises Pa(VI). Collision-induced dissociation of PaO(2)(2+) suggested the protactinyl connectivity, {O-Pa-O}(2+). The experimentally determined IE[PaO(2)(+)] approximately 16.6 eV is in agreement with self-consistent-field and configuration interaction calculations for PaO(2)(+) and PaO(2)(2+). These calculations provide insights into the electronic structures of these ions and indicate the participation of 5f orbitals in bonding and a partial "6p hole" in the case of protactinyl. It was found that PaO(2)(2+) catalyzes the oxidation of CO by N(2)O-such O atom transport via a dipositive metal oxide ion is distinctive. It was also observed that PaO(2)(2+) is capable of activating H(2) to form the stable PaO(2)H(2+) ion.

  13. Oxidation of gas-phase protactinium ions, Pa+ and Pa2+: formation and properties of PaO2(2+)(g), protactinyl.

    PubMed

    Santos, Marta; de Matos, António Pires; Marçalo, Joaquim; Gibson, John K; Haire, Richard G; Tyagi, Rajni; Pitzer, Russell M

    2006-05-01

    Oxidation reactions of bare and ligated, monopositive, and dipositive Pa ions in the gas phase were studied by Fourier transform ion cyclotron resonance mass spectrometry. Seven oxidants were employed, ranging from the thermodynamically robust N(2)O to the relatively weak CH(2)O-all oxidized Pa(+) to PaO(+) and PaO(+) to PaO(2)(+). On the basis of experimental observations, it was established that D[Pa(+)-O] and D[OPa(+)-O] > or = 751 kJ mol(-1). Estimates for D[Pa(+)-O], D[OPa(+)-O], IE[PaO], and IE[PaO(2)] were also obtained. The seven oxidants reacted with Pa(2+) to produce PaO(2+), indicating that D[Pa(2+)-O] > or = 751 kJ mol(-1). A particularly notable finding was the oxidation of PaO(2+) by N(2)O to PaO(2)(2+), a species, which formally comprises Pa(VI). Collision-induced dissociation of PaO(2)(2+) suggested the protactinyl connectivity, {O-Pa-O}(2+). The experimentally determined IE[PaO(2)(+)] approximately 16.6 eV is in agreement with self-consistent-field and configuration interaction calculations for PaO(2)(+) and PaO(2)(2+). These calculations provide insights into the electronic structures of these ions and indicate the participation of 5f orbitals in bonding and a partial "6p hole" in the case of protactinyl. It was found that PaO(2)(2+) catalyzes the oxidation of CO by N(2)O-such O atom transport via a dipositive metal oxide ion is distinctive. It was also observed that PaO(2)(2+) is capable of activating H(2) to form the stable PaO(2)H(2+) ion. PMID:16640369

  14. Spatial arrangement and functional role of α subunits of proteasome activator PA28 in hetero-oligomeric form

    SciTech Connect

    Sugiyama, Masaaki; Sahashi, Hiroki; Kurimoto, Eiji; Takata, Shin-ichi; Yagi, Hirokazu; Kanai, Keita; Sakata, Eri; Minami, Yasufumi; Tanaka, Keiji; Kato, Koichi

    2013-03-01

    Highlights: ► Homologous α and β subunits are alternatively arranged in the PA28 heptameric ring. ► The flexible loops of the three α subunits surround the site of substrate entry. ► The loops serve as gatekeepers that selectively hinder passage of longer peptides. - Abstract: A major form of proteasome activator PA28 is a heteroheptamer composed of interferon-γ-inducible α and β subunits, which share approximately 50% amino acid identity and possess distinct insert loops. This activator forms a complex with the 20S proteasome and thereby stimulates proteasomal degradation of peptides in an ATP-independent manner, giving rise to smaller antigenic peptides presented by major histocompatibility complex class I molecules. In this study, we performed biophysical and biochemical characterization of the structure and function of the PA28 hetero-oligomer. Deuteration-assisted small-angle neutron scattering demonstrated three α and four β subunits are alternately arranged in the heptameric ring. In this arrangement, PA28 loops surround the central pore of the heptameric ring (site for peptide entry). Activating the 20S proteasome with a PA28 mutant that lacked the α subunit loops cleaved model substrates longer than a nonapeptide with better efficiency when compared to wild-type PA28. Based on these data, we hypothesize that the flexible PA28 loops act as gatekeepers, which function to select the length of peptide substrates to be transported between the proteolytic chamber and the extra-proteasomal medium.

  15. TMPRSS4 upregulates uPA gene expression through JNK signaling activation to induce cancer cell invasion.

    PubMed

    Min, Hye-Jin; Lee, Yunhee; Zhao, Xue-Feng; Park, Young-Kyu; Lee, Myung Kyu; Lee, Jung Weon; Kim, Semi

    2014-02-01

    TMPRSS4 is a novel type II transmembrane serine protease that is highly expressed in pancreatic, thyroid, colon, and other cancer tissues. Previously, we demonstrated that TMPRSS4 mediates tumor cell invasion, migration, and metastasis. However, the mechanisms by which TMPRSS4 contributes to invasion are not fully understood. Here, we demonstrated that TMPRSS4 induced the transcription of the urokinase-type plasminogen activator (uPA) gene through activating the transcription factors Sp1, Sp3, and AP-1 in mainly a JNK-dependent manner and that the induction of uPA was required for TMPRSS4-mediated cancer cell invasion and signaling events. In addition, the uPA receptor was involved in TMPRSS4-induced signaling activation and subsequent uPA expression probably through its association with TMPRSS4 on the cell surface. Immunohistochemical analysis showed that uPA expression was significantly correlated with TMPRSS4 expression in human lung and prostate cancers. These observations suggest that TMPRSS4 is an important regulator of uPA gene expression; the upregulation of uPA by TMPRSS4 contributes to invasion and may represent a novel mechanism for the control of invasion. PMID:23978400

  16. Australian Small Business Participation in Training Activities

    ERIC Educational Resources Information Center

    Webster, Beverley; Walker, Elizabeth; Brown, Alan

    2005-01-01

    Purpose: This purpose of this paper is to investigate the use of on-line training by small businesses in Australia. It explores the relationship between the owners acceptance and use of the Internet, and their current participation in training opportunities. Design/Methodology/Approach: A sample of small businesses which had participated in an…

  17. Pakistani Children's Participation in Health Promotion Activities

    ERIC Educational Resources Information Center

    Ahmed, Shabnam

    2011-01-01

    This paper examines the effects of a Child-to-Child (CtC) health education programme designed to assist children in Pakistan to greater participation and voice in both their own education and their families' health by empowering them as change agents. The study compares parental involvement in their children's participation in health promotion…

  18. Contribution of the nitroimidazoles PA-824 and TBA-354 to the activity of novel regimens in murine models of tuberculosis.

    PubMed

    Tasneen, Rokeya; Williams, Kathy; Amoabeng, Opokua; Minkowski, Austin; Mdluli, Khisimuzi E; Upton, Anna M; Nuermberger, Eric L

    2015-01-01

    New regimens based on two or more novel agents are sought in order to shorten or simplify the treatment of both drug-susceptible and drug-resistant forms of tuberculosis. PA-824 is a nitroimidazo-oxazine now in phase II trials and has shown significant early bactericidal activity alone and in combination with the newly approved agent bedaquiline or with pyrazinamide with or without moxifloxacin. While the development of PA-824 continues, a potential next-generation derivative, TBA-354, has been discovered to have in vitro potency superior to that of PA-824 and greater metabolic stability than that of the other nitroimidazole derivative in clinical development, delamanid. In the present study, we compared the activities of PA-824 and TBA-354 as monotherapies in murine models of the initial intensive and continuation phases of treatment, as well as in combination with bedaquiline plus pyrazinamide, sutezolid, and/or clofazimine. The monotherapy studies demonstrated that TBA-354 is 5 to 10 times more potent than PA-824, but selected mutants are cross-resistant to PA-824 and delamanid. The combination studies revealed that TBA-354 is 2 to 4 times more potent than PA-824 when combined with bedaquiline, and when administered at a dose equivalent to that of PA-824, TBA-354 demonstrated superior sterilizing efficacy. Perhaps most importantly, the addition of either nitroimidazole significantly improved the sterilizing activities of bedaquiline and sutezolid, with or without pyrazinamide, confirming the value of each agent in this potentially universally active short-course regimen.

  19. Contribution of the Nitroimidazoles PA-824 and TBA-354 to the Activity of Novel Regimens in Murine Models of Tuberculosis

    PubMed Central

    Tasneen, Rokeya; Williams, Kathy; Amoabeng, Opokua; Minkowski, Austin; Mdluli, Khisimuzi E.; Upton, Anna M.

    2014-01-01

    New regimens based on two or more novel agents are sought in order to shorten or simplify the treatment of both drug-susceptible and drug-resistant forms of tuberculosis. PA-824 is a nitroimidazo-oxazine now in phase II trials and has shown significant early bactericidal activity alone and in combination with the newly approved agent bedaquiline or with pyrazinamide with or without moxifloxacin. While the development of PA-824 continues, a potential next-generation derivative, TBA-354, has been discovered to have in vitro potency superior to that of PA-824 and greater metabolic stability than that of the other nitroimidazole derivative in clinical development, delamanid. In the present study, we compared the activities of PA-824 and TBA-354 as monotherapies in murine models of the initial intensive and continuation phases of treatment, as well as in combination with bedaquiline plus pyrazinamide, sutezolid, and/or clofazimine. The monotherapy studies demonstrated that TBA-354 is 5 to 10 times more potent than PA-824, but selected mutants are cross-resistant to PA-824 and delamanid. The combination studies revealed that TBA-354 is 2 to 4 times more potent than PA-824 when combined with bedaquiline, and when administered at a dose equivalent to that of PA-824, TBA-354 demonstrated superior sterilizing efficacy. Perhaps most importantly, the addition of either nitroimidazole significantly improved the sterilizing activities of bedaquiline and sutezolid, with or without pyrazinamide, confirming the value of each agent in this potentially universally active short-course regimen. PMID:25331697

  20. Current perspectives on the use of intravenous recombinant tissue plasminogen activator (tPA) for treatment of acute ischemic stroke

    PubMed Central

    Chapman, Sherita N; Mehndiratta, Prachi; Johansen, Michelle C; McMurry, Timothy L; Johnston, Karen C; Southerland, Andrew M

    2014-01-01

    In 1995, the NINDS (National Institute of Neurological Disorders and Stroke) tPA (tissue plasminogen activator) Stroke Study Group published the results of a large multicenter clinical trial demonstrating efficacy of intravenous tPA by revealing a 30% relative risk reduction (absolute risk reduction 11%–15%) compared with placebo at 90 days in the likelihood of having minimal or no disability. Since approval in 1996, tPA remains the only drug treatment for acute ischemic stroke approved by the US Food and Drug Administration. Over the years, an abundance of research and clinical data has supported the safe and efficacious use of intravenous tPA in all eligible patients. Despite such supporting data, it remains substantially underutilized. Challenges to the utilization of tPA include narrow eligibility and treatment windows, risk of symptomatic intracerebral hemorrhage, perceived lack of efficacy in certain high-risk subgroups, and a limited pool of neurological and stroke expertise in the community. With recent US census data suggesting annual stroke incidence will more than double by 2050, better education and consensus among both the medical and lay public are necessary to optimize the use of tPA for all eligible stroke patients. Ongoing and future research should continue to improve upon the efficacy of tPA through more rapid stroke diagnosis and treatment, refinement of advanced neuroimaging and stroke biomarkers, and successful demonstration of alternative means of reperfusion. PMID:24591838

  1. Antimicrobial activity of pediocin PA-1 against Oenococcus oeni and other wine bacteria.

    PubMed

    Díez, Lorena; Rojo-Bezares, Beatriz; Zarazaga, Myriam; Rodríguez, Juan M; Torres, Carmen; Ruiz-Larrea, Fernanda

    2012-09-01

    Pediocin PA-1 is an antimicrobial peptide produced by lactic acid bacteria (LAB) that has been sufficiently well characterised to be used in food industry as a biopreservative. Sulphur dioxide is the traditional antimicrobial agent used during the winemaking process to control bacterial growth and wine spoilage. In this study, we describe the effect of pediocin PA-1 alone and in combination with sulphur dioxide and ethanol on the growth of a collection of 53 oenological LAB, 18 acetic acid bacteria and 16 yeast strains; in addition, production of pediocin PA-1 by Pediococcus acidilactici J347-29 in presence of ethanol and grape must is also reported. Inhibitory concentrations (IC) and minimal bactericide concentrations of pediocin PA-1 were determined against LAB, and revealed a bacteriostatic effect. Oenococcus oeni resulted more sensitive to pediocin PA-1 (IC(50) = 19 ng/ml) than the other LAB species (IC(50) = 312 ng/ml). Cooperative inhibitory effects of pediocin PA-1 and either sulphur dioxide or ethanol were observed on LAB growth. Moreover, the pediocin PA-1 producing P. acidilactici strain J347-29 was able to grow and produce the bacteriocin in presence of ethanol (up to 4% ethanol in the fermentation broth) and grape must (up to 80%), which indicated that pediocin PA-1 can be considered as a potential biopreservative in winemaking.

  2. Physical activity participation by parental language use in 4th, 8th, and 11th grade students in Texas, USA.

    PubMed

    Springer, Andrew E; Lewis, Kayan; Kelder, Steven H; Fernandez, Maria E; Barroso, Cristina S; Hoelscher, Deanna M

    2010-10-01

    Research on physical activity (PA) by level of acculturation in Hispanic children is limited and findings have been mixed. We examined PA participation by primary language used with parents in a representative sample of 4th, 8th, and 11th grade Texas public school students. Mixed-effects regression models were conducted using cross-sectional data from the 2004-2005 School Physical Activity and Nutrition Study (n = 22,049). Self-reported PA was compared among three language-ethnic groups: Spanish-Hispanic (SH) (referent); English-Hispanic (EH); and English-Other (EO). EH and/or EO girls were generally between 1.25 and 2.58 [OR] times more likely to participate in PA across grade levels, with the largest differences found for school sports in 8th grade girls. EH and EO 8th grade boys were 1.71 (CI: 1.40, 2.10) and 2.06 (CI: 1.68, 2.51) times, respectively, more likely to participate in school sports. Findings indicate important disparities in Spanish-speaking Hispanic children's PA participation. PMID:19365728

  3. Active Participation in the Literary Encounter.

    ERIC Educational Resources Information Center

    Twining, James E.

    A child's sense of involvement in story and desire to meaningfully experience literature must be sustained and promoted if the problem of "literacy" is to be resolved. Four activities, designed as a series of stages, can enhance the literary experience of children. The first activity is reading to children--exposing them to the language…

  4. 5 CFR 734.203 - Participation in nonpartisan activities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Participation in nonpartisan activities... Participation in nonpartisan activities. An employee may: (a) Express his or her opinion privately and publicly... nonpartisan activities of a civic, community, social, labor, or professional organization, or of a...

  5. Pharmacologic partial salvage of a failing free flap with recombinant tissue plasminogen activator (rt-PA).

    PubMed

    Atiyeh, B S; Fuleihan, N S; Musharafieh, R S

    1999-11-01

    Despite all the technical improvements in microvascular surgery and the experience gained in clinical practice, thrombosis at the site of microanastomosis remains a significant problem and a continuous source of frustration to most microsurgeons. Early recognition of vascular complications and prompt reexploration with vascular revision remain an essential and standard conduct for salvage. However, in situations where conditions for no-reflow have been established due to severe vasospasm or prolonged ischemia time, it becomes obvious that surgical reexploration alone is not enough to salvage a failing flap or a replanted limb. In such situations, the loss of the revascularized tissues seems to be inevitable. The authors describe their experience in partially salvaging a failing free flap with recombinant tissue plasminogen activator (rt-PA), reversing an established state of no-reflow. Pharmacologic manipulation of the complex and variable factors influencing anastomotic patency in microvascular tissue transfer seems to offer a new hope for preventing failures, as well as for salvaging failing flaps. It appears also that free-tissue transfer failure is not an all-or-none phenomenon.

  6. Late Quaternary mass-wasting records in the actively uplifting Pa-chang catchment, southwestern Taiwan

    NASA Astrophysics Data System (ADS)

    Hsieh, Meng-Long; Ching, Kuo-En; Chyi, Shyh-Jeng; Kang, Su-Chen; Chou, Chun-Yen

    2014-07-01

    Although dominated by erosion over long term, the tectonically active mountains of Taiwan commonly contain thick landslide and debris-flow gravels capping hillslopes or forming alluvial terraces. These deposits and their associated landforms serve to study ancient mass-wasting histories and their controls on fluvial processes. This study focuses on the Pa-chang River draining the < 2000 m high Ali-shan area in southwestern Taiwan (current tectonic uplift: 5-8 mm yr- 1). Although small (catchment area: 83 km2), the Pa-chang exhibits one of the largest alluvial terraces in Taiwan, which stretches from the outlet of the catchment for 9 km along the river and comprises fluvial and debris-flow gravels up to 150 m thick. Totally 55 radiocarbon dates have been obtained, tracing the mass-wasting records back to 14.8 ka. The largest events, which created the studied major terraces, occurred in 10.0-11.3 and 8.7-9.4 ka. These events are synchronous with the formation of some regionally largest alluvial terraces in Taiwan, and may have been triggered by the frequent heavy rains associated with the early Holocene East Asian summer-monsoon maximum. More mass-wasting events have been dated at ~ 5.4, ~ 1.9, 1.2-1.7, 0.7-0.9, ~ 0.6, and < 0.3 ka. The vast supply of sediment from the recorded mass-wasting events not only caused river aggradation but also regulated the subsequent incision by forming boulder armors. As a result, the bedrock incision in the upper part of the catchment has been negligible since the early Holocene debris-flow deposition. The incision rates increase to the downstream direction as the size and concentration of boulders reduce. Still, the 14.8 ka-averaged bedrock incision rate (< 4.5 mm yr- 1) at the catchment outlet is lower than the current uplift rate (6 mm yr- 1). At the same site, however, the bedrock incision rate is 23 mm yr- 1 averaged over the past 0.6 ka. Even higher rates of incision (> 50 mm yr- 1) are detected further downstream after the

  7. What a man wants: understanding the challenges and motivations to physical activity participation and healthy eating in middle-aged Australian men.

    PubMed

    Caperchione, Cristina M; Vandelanotte, Corneel; Kolt, Gregory S; Duncan, Mitch; Ellison, Marcus; George, Emma; Mummery, W Kerry

    2012-11-01

    Little attention has been paid to the physical activity (PA) and nutrition behaviors of middle-aged men; thus, the aim of this study was to gather information and gain insight into the PA and nutrition behaviors of these men. Six focus group sessions were undertaken with middle-aged men (N = 30) from regional Australia to explore the challenges and motivations to PA participation and healthy eating. Men had a good understanding of PA and nutrition; however, this was sometimes confounded by inconsistent media messages. Work commitments and family responsibilities were barriers to PA, while poor cooking skills and abilities were barriers to healthy eating. Disease prevention, weight management, and being a good role model were motivators for PA and healthy eating. By understanding what a man wants, PA and nutrition interventions can be designed and delivered to meet the needs of this hard-to-reach population.

  8. Massive Open Online Courses (MOOCs): Participant Activity, Demographics, and Satisfaction

    ERIC Educational Resources Information Center

    Shrader, Sara; Wu, Maryalice; Owens, Dawn; Santa Ana, Kathleen

    2016-01-01

    This paper examines activity patterns, participant demographics, and levels of satisfaction in multiple MOOC offerings at the University of Illinois at Urbana-Champaign from August 2012-December 2013. Using the following guiding questions: "Who are MOOC participants, how do they participate, and were they able to get what they wanted out of…

  9. Geochemical data package for the Hanford immobilized low-activity tank waste performance assessment (ILAW PA)

    SciTech Connect

    DI Kaplan; RJ Serne

    2000-02-24

    Lockheed Martin Hanford Company (LMHC) is designing and assessing the performance of disposal facilities to receive radioactive wastes that are stored in single- and double-shell tanks at the Hanford Site. The preferred method of disposing of the portion that is classified as low-activity waste is to vitrify the liquid/slurry and place the solid product in near-surface, shallow-land burial facilities. The LMHC project to assess the performance of these disposal facilities is the Hanford Immobilized Low-Activity Tank Waste (ILAW) Performance Assessment (PA) activity. The goal of this project is to provide a reasonable expectation that the disposal of the waste is protective of the general public, groundwater resources, air resources, surface-water resources, and inadvertent intruders. Achieving this goal will require prediction of contaminant migration from the facilities. This migration is expected to occur primarily via the movement of water through the facilities, and the consequent transport of dissolved contaminants in the porewater of the vadose zone. Pacific Northwest National Laboratory assists LMHC in their performance assessment activities. One of the PNNL tasks is to provide estimates of the geochemical properties of the materials comprising the disposal facility, the disturbed region around the facility, and the physically undisturbed sediments below the facility (including the vadose zone sediments and the aquifer sediments in the upper unconfined aquifer). The geochemical properties are expressed as parameters that quantify the adsorption of contaminants and the solubility constraints that might apply for those contaminants that may exceed solubility constraints. The common parameters used to quantify adsorption and solubility are the distribution coefficient (K{sub d}) and the thermodynamic solubility product (K{sub sp}), respectively. In this data package, the authors approximate the solubility of contaminants using a more simplified construct

  10. Walking Patterns in a Sample of African American, Native American, and Caucasian Women: The Cross-Cultural Activity Participation Study

    ERIC Educational Resources Information Center

    Whitt, Melicia C.; DuBose, Katrina D.; Ainsworth, Barbara E.; Tudor-Locke, Catrine

    2004-01-01

    This analysis describes walking patterns among African American, Native American, and Caucasian women from South Carolina and New Mexico. Walking was assessed using pedometer and physical activity (PA) record data based on 4 consecutive days on either three (Study Phase 1) or two (Study Phase 2) occasions. Participants walked 5,429 [plus or minus]…

  11. Improved antimicrobial activities of synthetic-hybrid bacteriocins designed from enterocin E50-52 and pediocin PA-1.

    PubMed

    Tiwari, Santosh Kumar; Sutyak Noll, Katia; Cavera, Veronica L; Chikindas, Michael L

    2015-03-01

    Two hybrid bacteriocins, enterocin E50-52/pediocin PA-1 (EP) and pediocin PA-1/enterocin E50-52 (PE), were designed by combining the N terminus of enterocin E50-52 and the C terminus of pediocin PA-1 and by combining the C terminus of pediocin PA-1 and the N terminus of enterocin E50-52, respectively. Both hybrid bacteriocins showed reduced MICs compared to those of their natural counterparts. The MICs of hybrid PE and EP were 64- and 32-fold lower, respectively, than the MIC of pediocin PA-1 and 8- and 4-fold lower, respectively, than the MIC of enterocin E50-52. In this study, the effect of hybrid as well as wild-type (WT) bacteriocins on the transmembrane electrical potential (ΔΨ) and their ability to induce the efflux of intracellular ATP were investigated. Enterocin E50-52, pediocin PA-1, and hybrid bacteriocin PE were able to dissipate ΔΨ, but EP was unable to deplete this component. Both hybrid bacteriocins caused a loss of the intracellular concentration of ATP. EP, however, caused a faster efflux than PE and enterocin E50-52. Enterocin E50-52 and hybrids PE and EP were active against the Gram-positive and Gram-negative bacteria tested, such as Micrococcus luteus, Salmonella enterica serovar Enteritidis 20E1090, and Escherichia coli O157:H7. The hybrid bacteriocins designed and described herein are antimicrobial peptides with MICs lower those of their natural counterparts. Both hybrid peptides induce the loss of intracellular ATP and are capable of inhibiting Gram-negative bacteria, and PE dissipates the electrical potential. In this study, the MIC of hybrid bacteriocin PE decreased 64-fold compared to the MIC of its natural peptide counterpart, pediocin PA-1. Inhibition of Gram-negative pathogens confers an additional advantage for the application of these peptides in therapeutics.

  12. Patterns of Children's Participation in Unorganized Physical Activity

    ERIC Educational Resources Information Center

    Findlay, Leanne C.; Garner, Rochelle E.; Kohen, Dafna E.

    2010-01-01

    Children's leisure-time or unorganized physical activity is associated with positive physical and mental health, yet there is little information available on tracking and predicting participation throughout the childhood and adolescent years. The purpose of the current study was to explore patterns of unorganized physical activity participation of…

  13. 27 CFR 6.100 - Participation in retailer association activities.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2013-04-01 2013-04-01 false Participation in retailer association activities. 6.100 Section 6.100 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL âTIED-HOUSEâ Exceptions § 6.100 Participation in retailer association activities....

  14. 27 CFR 6.100 - Participation in retailer association activities.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Participation in retailer association activities. 6.100 Section 6.100 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS âTIED-HOUSEâ Exceptions § 6.100 Participation in retailer association activities....

  15. 27 CFR 6.100 - Participation in retailer association activities.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2014-04-01 2014-04-01 false Participation in retailer association activities. 6.100 Section 6.100 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL âTIED-HOUSEâ Exceptions § 6.100 Participation in retailer association activities....

  16. 26 CFR 1.219-2 - Definition of active participant.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... under the plan to accrue a benefit. For example, assume a plan is integrated with Social Security and... taxable year by reason of attaining a specified age is not an active participant by reason of his... rule. An individual is not an active participant for a particular taxable year by reason of...

  17. Participating in sport and music activities in adolescence: the role of activity participation and motivational beliefs during elementary school.

    PubMed

    Simpkins, Sandra D; Vest, Andrea E; Becnel, Jennifer N

    2010-11-01

    This investigation examined the precursors of adolescents' participation in sport and music activities in the United States by testing a developmental model across 7 years. Data were drawn from youth questionnaires in the Childhood and Beyond Study (92% European American; N = 594). Findings suggest that patterns of participation across a 3-year period in elementary school predict adolescents' participation through their motivational beliefs. Specifically, children who participated in an activity, children who participated consistently across multiple years, and children who were highly active had higher adolescent motivational beliefs 4 years later than their peers. These motivational beliefs, in turn, positively predicted adolescents' participation 1 year later. Cross-domain analyses suggest that children typically maintain their orientation toward sports and music (e.g., high music-low sport orientation, not oriented toward either domain) as they age. These findings highlight the consistency in children's leisure pursuits and interests from childhood through adolescence.

  18. University Student Participation and Perception of Intramural Program Activities.

    ERIC Educational Resources Information Center

    Zuercher, Suzanne; And Others

    A sample of 286 University of Maryland, College Park, undergraduates were surveyed on their participation in and their perception of the intramural sports program and related activities of the institution. Ninety-three percent of those surveyed was aware of the intramural program and 43 percent indicated that they participated (70 percent male, 30…

  19. Comparing Participation in Activities among Children with Disabilities

    ERIC Educational Resources Information Center

    Masse, Louise C.; Miller, Anton R.; Shen, Jane; Schiariti, Veronica; Roxborough, Lori

    2012-01-01

    Introduction: Compared to typically developing peers, children with disabilities due to neurodevelopmental disorders and disabilities (NDD/D) and to chronic medical conditions (CMC) have reduced participation in activities. The extent to which these two groups of children have different levels of participation is unknown and was examined in this…

  20. Iowa Consumer Trends and Participation in Agritourism Activities

    ERIC Educational Resources Information Center

    Nasers, Melissa S.; Retallick, Michael S.

    2012-01-01

    As the agritourism industry grows and develops in Iowa, it is important to identify the knowledge and participation levels of prospective agritourism consumers. This article focuses on current consumer trends and participation levels in Iowa agritourism activities. The results revealed a majority of Iowans believe they have at least some…

  1. Parental Mediatory Role in Children's Physical Activity Participation

    ERIC Educational Resources Information Center

    Cheung, P. Y. Peggy; Chow, Bik C.

    2010-01-01

    Purpose: Parents are important agents in the physical activity socializing process in children. The present study aims to examine the parental mediatory role in children's physical activity participation via a youth physical activity promotion (YPAP) model. Design/methodology/approach: A total of 872 Hong Kong Chinese children (aged ten to 13) in…

  2. 27 CFR 6.100 - Participation in retailer association activities.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... association activities. 6.100 Section 6.100 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND... retailer association activities. The following acts by an industry member participating in retailer association activities do not constitute a means to induce within the meaning of section 105(b)(3) of the...

  3. 27 CFR 6.100 - Participation in retailer association activities.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... association activities. 6.100 Section 6.100 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND... retailer association activities. The following acts by an industry member participating in retailer association activities do not constitute a means to induce within the meaning of section 105(b)(3) of the...

  4. The Role of Schools in Children's Physical Activity Participation: Staff Perceptions

    ERIC Educational Resources Information Center

    Huberty, J.; Dinkel, D.; Coleman, J.; Beighle, A.; Apenteng, B.

    2012-01-01

    The school setting provides a promising environment to increase children's physical activity (PA), however, staff often impact the success of PA within schools. The purpose of this article was to describe the knowledge of elementary school staff related to PA and their perception of the importance of the school environment being conducive to PA…

  5. Psychological Changes among Muslim Students Participating in a Faith-Based School Physical Activity Program

    ERIC Educational Resources Information Center

    Nicaise, Virginie; Kahan, David

    2013-01-01

    Purpose: Some religions espouse doctrines that (in)directly impact physical activity (PA) behavior. Yet limited PA interventions have been tailored to religious minorities. Thus, a formative study was conducted to examine the effect of a faith-based pedometer program (Virtual Umra) on psychological correlates of PA behavior and their contribution…

  6. Health locus of control and participation in physical activity.

    PubMed

    Carlson, B R; Petti, K

    1989-01-01

    Abstract The purpose of this study was to determine the physical activity participation patterns of college students when defined by their Health Locus of Control orientation. One thousand thirty-three college-aged students completed the Wellness Activity Profile, a questionnaire that yielded data on Health Locus of Control and self-reported frequency of participation in physical activities. Discriminant analyses indicated that the combination of physical activities associated with internally and externally oriented students were different for both males and females. Participation in high caloric expenditure activities was more frequent among internal subjects (Male: bicycling, volleyball, other individual sports, and snorkel/scuba diving; Female: basketball, weight training, tennis, fast walking/jogging/running, and judo/karate), while low caloric expenditure activities were associated with an external orientation (Male: baseball/softball, sailing, fishing, golf, and other recreational sports; Female: track and field jumping and fishing).

  7. Participating in Sport and Music Activities in Adolescence: The Role of Activity Participation and Motivational Beliefs during Elementary School

    ERIC Educational Resources Information Center

    Simpkins, Sandra D.; Vest, Andrea E.; Becnel, Jennifer N.

    2010-01-01

    This investigation examined the precursors of adolescents' participation in sport and music activities in the United States by testing a developmental model across 7 years. Data were drawn from youth questionnaires in the Childhood and Beyond Study (92% European American; N = 594). Findings suggest that patterns of participation across a 3-year…

  8. Silent Participation: East Asian International Graduate Students' Views on Active Classroom Participation

    ERIC Educational Resources Information Center

    Kim, Soonhyang

    2008-01-01

    The author reports on perceptions of East Asian international graduate students (EAGS) regarding active classroom participation, as revealed through two focus group interviews with 15 EAGS at a large Midwestern research university in the U.S. The findings indicate that most EAGS shared similar views with their university instructors and American…

  9. Biological activity and binding site characteristics of the PA1b Entomotoxin on insects from different orders.

    PubMed

    Gressent, Frédéric; Duport, Gabrielle; Rahioui, Isabelle; Pauchet, Yannick; Bolland, Patrice; Specty, Olivier; Rahbe, Yvan

    2007-01-01

    The aim of this work was to investigate both the biological activity of an entomotoxin, the pea albumin 1b (PA1b), and the presence or absence of its binding site within an array of insect species. The data obtained showed that insect sensitivity was not related to its taxonomic position. Moreover, PA1b was not toxic to several tested microorganisms. However, the binding site was found to be conserved among very different insects, displaying similar thermodynamic constants regardless of the in vivo species sensitivity. The binding site alone was, therefore, not sufficient for toxicity. One exception was the pea weevil, Bruchus pisorum, which was the only tested species without any detectable binding activity. These findings indicate that the binding site probably has an important endogenous function in insects and that adaptation to pea seeds resulted in the elimination of the toxin binding activity in two independent insect lineages. Other mechanisms are likely to interact with the toxin effects, although they are still largely unknown, but there is no evidence of any specific degradation of PA1b in the midgut of insects insensitive to the toxin, such as Drosophila melanogaster or Mamestra brassicae.

  10. High-level expression of a novel recombinant human plasminogen activator (rhPA) in the milk of transgenic rabbits and its thrombolytic bioactivity in vitro.

    PubMed

    Song, Shaozheng; Ge, Xin; Cheng, Yaobin; Lu, Rui; Zhang, Ting; Yu, Baoli; Ji, Xueqiao; Qi, Zhengqiang; Rong, Yao; Yuan, Yuguo; Cheng, Yong

    2016-08-01

    The human tissue-type plasminogen activator (tPA) is a key kinase of fibrinolysis that plays an important role in dissolving fibrin clots to promote thrombolysis. The recombinant human plasminogen activator (rhPA) has more thrombolytic advantages than the wild type tPA. To increase the half-life and thrombolytic activity of tPA, a mutant containing only the essential K2 fibrin-binding and P activating plasminogen domains of the wild type tPA was cloned. This fragment was then inserted into goat β-casein regulatory sequences. Then, a mammary gland-specific expression vector, PCL25/rhPA, was constructed, and the transgenic rabbits were generated. In this study, 18 live transgenic founders (12♀, 6♂) were generated using pronuclear microinjection. Six transgenic rabbits were obtained, and the expression levels of rhPA in the milk had a range of 15.2-630 µg/ml. A fibrin agarose plate assay of rhPA showed that it had strong thrombolytic bioactivity in vitro, and the highest specific activity was >360 (360 times more than that of alteplase). The results indicated that the rhPA containing only the K2 and P domains is efficiently expressed with higher thrombolytic bioactivity in the milk of transgenic rabbits. Our study also demonstrated a new method for the large-scale production of clinically relevant recombinant pharmaceutical proteins in the mammary glands of transgenic rabbits. PMID:27230577

  11. t-PA-specific modulation of a human blood-brain barrier model involves plasmin-mediated activation of the Rho kinase pathway in astrocytes.

    PubMed

    Niego, Be'eri; Freeman, Roxann; Puschmann, Till B; Turnley, Ann M; Medcalf, Robert L

    2012-05-17

    Tissue-type plasminogen activator (t-PA) can modulate permeability of the neurovascular unit and exacerbate injury in ischemic stroke. We examined the effects of t-PA using in vitro models of the blood-brain barrier. t-PA caused a concentration-dependent increase in permeability. This effect was dependent on plasmin formation and potentiated in the presence of plasminogen. An inactive t-PA variant inhibited the t-PA-mediated increase in permeability, whereas blockade of low-density lipoprotein receptors or exposed lysine residues resulted in similar inhibition, implying a role for both a t-PA receptor, most likely a low-density lipoprotein receptor, and a plasminogen receptor. This effect was selective to t-PA and its close derivative tenecteplase. The truncated t-PA variant reteplase had a minor effect on permeability, whereas urokinase and desmoteplase were ineffective. t-PA also induced marked shape changes in both brain endothelial cells and astrocytes. Changes in astrocyte morphology coincided with increased F-actin staining intensity, larger focal adhesion size, and elevated levels of phosphorylated myosin. Inhibition of Rho kinase blocked these changes and reduced t-PA/plasminogen-mediated increase in permeability. Hence plasmin, generated on the cell surface selectively by t-PA, modulates the astrocytic cytoskeleton, leading to an increase in blood-brain barrier permeability. Blockade of the Rho/Rho kinase pathway may have beneficial consequences during thrombolytic therapy.

  12. 32 CFR 701.123 - PA fees.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false PA fees. 701.123 Section 701.123 National... DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.123 PA fees. The PA fee schedule is only applicable... PA system of record. DON activities receiving requests under PA, FOIA, or PA/FOIA shall only...

  13. Motives of College Women for Participating in Physical Activities.

    ERIC Educational Resources Information Center

    Lundegren, Herberta

    One hundred and fifty-one college women, 88 non-physical education majors, and 63 physical education majors were given a 75-item Q-sort of statements on motives for participation in physical activity and a background questionnaire that elicited demographic data and information on sports activity experience. The Q-sort data for each major group…

  14. Environmental guidance for public participation in environmental restoration activities

    SciTech Connect

    Not Available

    1991-11-01

    The US Department of Energy (DOE) is issuing this document, entitled Guidance on Public Participation for US Department of Energy Environmental Restoration Activities, to summarize policy and provide guidance for public participation in environmental restoration activities at DOE Headquarters, Field Offices, facilities, and laboratories. While the Office of Environmental Restoration and Waste Management (EM) has environmental restoration responsibility for the majority of DOE sites and facilities, other DOE Project Offices have similar responsibilities at their sites and facilities. This guidance is applicable to all environment restoration activities conducted by or for DOE under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA) as amended by the Superfund Amendments and Reauthorization Act of 1986 (SARA); the Resource Conservation and Recovery Act of 1976 (RCRA) as amended by the Hazardous and Solid Waste Amendments of 1984 (HSWA) (corrective actions only); and the National Environmental Policy Act of 1969 (NEPA). This guidance also is applicable to CERCLA remedial action programs under the Uranium Mill Tailings Radiation Control Act of 1978 and the Formerly Utilized Sites Remedial Action Program, where DOE is the designated lead. The primary objectives of this guidance document are as follows: acclimate DOE staff to a changing culture that emphasizes the importance of public participation activities; provide direction on implementing these public participation activities; and, provide consistent guidance for all DOE Field Offices and facilities. The purpose of this document is to provide guidance on conducting effective public participation activities for environmental restoration activities under CERCLA; RCRA corrective actions under sections 3004(u), 3004(v), and 3008(h); and NEPA public participation activities.

  15. 23 CFR Appendix F to Part 1200 - PLANNING AND ADMINISTRATION (P&A) COSTS

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 23 Highways 1 2013-04-01 2013-04-01 false PLANNING AND ADMINISTRATION (P&A) COSTS F APPENDIX F TO... HIGHWAY SAFETY GRANT PROGRAMS Pt. 1200, App. F APPENDIX F TO PART 1200—PLANNING AND ADMINISTRATION (P&A) COSTS (a) Policy. Federal participation in P&A activities shall not exceed 50 percent of the total...

  16. 23 CFR Appendix F to Part 1200 - Planning and Administration (P&A) Costs

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 23 Highways 1 2014-04-01 2014-04-01 false Planning and Administration (P&A) Costs F Appendix F to... HIGHWAY SAFETY GRANT PROGRAMS Pt. 1200, App. F Appendix F to Part 1200—Planning and Administration (P&A) Costs (a) Policy. Federal participation in P&A activities shall not exceed 50 percent of the total...

  17. Physical activity and senior games participation: benefits, constraints, and behaviors.

    PubMed

    Cardenas, David; Henderson, Karla A; Wilson, Beth E

    2009-04-01

    The purpose of the article was to examine the physical activity perceptions and behaviors of older adults who were active participants in a statewide senior games (i.e., North Carolina Senior Games; NCSG) program with its focus on year-round involvement through activities in local communities. A random sample of 440 older adults (55 years and older) completed a questionnaire in 2006 about their participation in community-based senior games. A uniqueness of this study is its focus on active older adults, which provides insight into how to maintain physical involvement. Older adults who were most active perceived the most benefits from senior games but did not necessarily have the fewest constraints. This study of NCSG as an organization designed to promote healthy living in communities offered an example of how a social-ecological framework aimed at health promotion can be applied. PMID:19451664

  18. The Determinants of Participation in Physical Activity in Malaysia

    PubMed Central

    Cheah, Yong Kang; Poh, Bee Koon

    2014-01-01

    Objectives In light of the importance of physical activity, the aim of the present study is to examine the factors affecting participation in physical activity among adults in Malaysia. Methods A logistic regression model and the Third National Health and Morbidity Survey consisting of 30,992 respondents were used. Results Age, income, gender, education, marital status, region, house locality, job characteristics, and medical conditions are significantly associated with participation in physical activity. In particular, old individuals, high income earners, females, the well-educated, widowed or divorced individuals, East Malaysians, urban dwellers, the unemployed, and individuals who are not diagnosed with hypercholesterolemia are less likely to be physically active than others. Conclusion Because sociodemographic and health factors play an important role in determining physical activity, the government should take them into account when formulating policy. PMID:24955308

  19. Participation of people with disabilities in selected activities.

    PubMed

    Dowler, J M; Jordan-Simpson, D A

    1990-01-01

    The Health and Activity Limitation Survey (HALS) surveyed disabled Canadians. The survey measured participation in selected cultural and leisure activities, the satisfaction of disabled people with their level of participation, and barriers to participation. Of those surveyed, 98.0% reported doing one or a combination of the following: watching television; listening to radio, records or tapes; reading. Those with speaking and "other" limitations used the telephone less than those with other types of limitations; similarly, those with severe disabilities used the telephone less than those with less-severe disabilities. Participation decreased with age for activities such as doing arts or crafts, gardening, and talking on the telephone. Those aged 65 and over were more likely to be satisfied with their activity than younger people. Overall, 47.4% of those with a severe disability wanted to do more, compared to 34.0% with a moderate disability and 26.2% with a slight disability. The physical inability to do more was the most-often cited barrier to increasing activity: 53.9% of men and 55.7% of women said it was a barrier. PMID:2151649

  20. Participation of people with disabilities in selected activities.

    PubMed

    Dowler, J M; Jordan-Simpson, D A

    1990-01-01

    The Health and Activity Limitation Survey (HALS) surveyed disabled Canadians. The survey measured participation in selected cultural and leisure activities, the satisfaction of disabled people with their level of participation, and barriers to participation. Of those surveyed, 98.0% reported doing one or a combination of the following: watching television; listening to radio, records or tapes; reading. Those with speaking and "other" limitations used the telephone less than those with other types of limitations; similarly, those with severe disabilities used the telephone less than those with less-severe disabilities. Participation decreased with age for activities such as doing arts or crafts, gardening, and talking on the telephone. Those aged 65 and over were more likely to be satisfied with their activity than younger people. Overall, 47.4% of those with a severe disability wanted to do more, compared to 34.0% with a moderate disability and 26.2% with a slight disability. The physical inability to do more was the most-often cited barrier to increasing activity: 53.9% of men and 55.7% of women said it was a barrier.

  1. Identifying solutions to increase participation in physical activity interventions within a socio-economically disadvantaged community: a qualitative study

    PubMed Central

    2014-01-01

    Background There is an urgent need to increase population levels of physical activity, particularly amongst those who are socio-economically disadvantaged. Multiple factors influence physical activity behaviour but the generalisability of current evidence to such ‘hard-to-reach’ population subgroups is limited by difficulties in recruiting them into studies. Also, rigorous qualitative studies of lay perceptions and perceptions of community leaders about public health efforts to increase physical activity are sparse. We sought to explore, within a socio-economically disadvantaged community, residents’ and community leaders’ perceptions of physical activity (PA) interventions and issues regarding their implementation, in order to improve understanding of needs, expectations, and social/environmental factors relevant to future interventions. Methods Within an ongoing regeneration project (Connswater Community Greenway), in a socio-economically disadvantaged community in Belfast, we collaborated with a Community Development Agency to purposively sample leaders from public- and voluntary-sector community groups and residents. Individual semi-structured interviews were conducted with 12 leaders. Residents (n = 113), of both genders and a range of ages (14 to 86 years) participated in focus groups (n = 14) in local facilities. Interviews and focus groups were recorded, transcribed verbatim and analysed using a thematic framework. Results Three main themes were identified: awareness of PA interventions; factors contributing to intervention effectiveness; and barriers to participation in PA interventions. Participants reported awareness only of interventions in which they were involved directly, highlighting a need for better communications, both inter- and intra-sectoral, and with residents. Meaningful engagement of residents in planning/organisation, tailoring to local context, supporting volunteers, providing relevant resources and an ‘exit strategy

  2. Short- and Long-Term Theory-Based Predictors of Physical Activity in Women Who Participated in a Weight-Management Program

    ERIC Educational Resources Information Center

    Wasserkampf, A.; Silva, M. N.; Santos, I. C.; Carraça, E. V.; Meis, J. J. M.; Kremers, S. P. J.; Teixeira, P. J.

    2014-01-01

    This study analyzed psychosocial predictors of the Theory of Planned Behavior (TPB) and Self-Determination Theory (SDT) and evaluated their associations with short- and long-term moderate plus vigorous physical activity (MVPA) and lifestyle physical activity (PA) outcomes in women who underwent a weight-management program. 221 participants (age…

  3. Validation of the Oxford Participation and Activities Questionnaire

    PubMed Central

    Morley, David; Dummett, Sarah; Kelly, Laura; Dawson, Jill; Fitzpatrick, Ray; Jenkinson, Crispin

    2016-01-01

    Purpose There is growing interest in the management of long-term conditions and in keeping people active and participating in the community. Testing the effectiveness of interventions that aim to affect activities and participation can be challenging without a well-developed, valid, and reliable instrument. This study therefore aims to develop a patient-reported outcome measure, the Oxford Participation and Activities Questionnaire (Ox-PAQ), which is theoretically grounded in the World Health Organization’s International Classification of Functioning, Disability, and Health (ICF) and fully compliant with current best practice guidelines. Methods Questionnaire items generated from patient interviews and based on the nine chapters of the ICF were administered by postal survey to 386 people with three neurological conditions: motor neuron disease, multiple sclerosis, and Parkinson’s disease. Participants also completed the Medical Outcomes Study (MOS) 36-Item Short Form Health Survey (SF-36) and EQ-5D-5L. Results Thus, 334 participants completed the survey, a response rate of 86.5%. Factor analysis techniques identified three Ox-PAQ domains, consisting of 23 items, accounting for 72.8% of variance. Internal reliability for the three domains was high (Cronbach’s α: 0.81–0.96), as was test–retest reliability (intraclass correlation: 0.83–0.92). Concurrent validity was demonstrated through highly significant relationships with relevant domains of the MOS SF-36 and the EQ- 5D-5L. Assessment of known-groups validity identified significant differences in Ox-PAQ scores among the three conditions included in the survey. Conclusion Results suggest that the Ox-PAQ is a valid and reliable measure of participation and activity. The measure will now be validated in a range of further conditions, and additional properties, such as responsiveness, will also be assessed in the next phase of the instrument’s development. PMID:27366108

  4. Determinants of Activity and Participation in Preschoolers with Developmental Delay

    ERIC Educational Resources Information Center

    Leung, Grantiana P. K.; Chan, Chetwyn C. H.; Chung, Raymond C. K.; Pang, Marco Y. C.

    2011-01-01

    According to the International Classification of Functioning, Disability and Health model endorsed by the World Health Organization, activity (the execution of a task or action by an individual), and participation (involvement in a life situation) are important components in the assessment of health and functioning of an individual. The purpose of…

  5. 17 CFR 242.101 - Activities by distribution participants.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Activities by distribution participants. 242.101 Section 242.101 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) REGULATIONS M, SHO, ATS, AC, AND NMS AND CUSTOMER MARGIN REQUIREMENTS FOR SECURITY...

  6. Making Sense of Participation in Cultural Activities for Children

    ERIC Educational Resources Information Center

    Hultgren, Frances; Johansson, Barbro

    2013-01-01

    Introduction: This paper investigates participatory practices in library activities for young children and their care-givers in a specific cultural context. Method: Using an ethnographic approach data were collected through participant observations of songtimes for babies and toddlers, and interviews and group interviews with staff and…

  7. Digital Storytelling: Capturing Children's Participation in Preschool Activities

    ERIC Educational Resources Information Center

    Kervin, Lisa; Mantei, Jessica

    2016-01-01

    Children should be active participants in the environments in which they engage. However in the prior to school setting, it is not necessarily clear to educators how children understand their role and place within that community. Lave and Wenger's (2005) situated learning theory provides a useful frame to consider this developing sense of…

  8. Active Classroom Participation in a Group Scribbles Primary Science Classroom

    ERIC Educational Resources Information Center

    Chen, Wenli; Looi, Chee-Kit

    2011-01-01

    A key stimulus of learning efficacy for students in the classroom is active participation and engagement in the learning process. This study examines the nature of teacher-student and student-student discourse when leveraged by an interactive technology--Group Scribbles (GS) in a Primary 5 Science classroom in Singapore which supports rapid…

  9. Examining Participation of University Students in Recreational Entertainment Marketing Activities

    ERIC Educational Resources Information Center

    Pala, Adem

    2016-01-01

    The aim of this study was to examine participation of university students in recreational entertainment marketing activities. The survey population consisted of university student in Marmara University Province of Istanbul. The sample constituted a total of 272 students (150 male and 122 female), determined by circumstantial method. The survey…

  10. Self-Concept and Participation in School Activities Reanalyzed.

    ERIC Educational Resources Information Center

    Winne, Philip H.; Walsh, John

    1980-01-01

    Yarworth and Gauthier (EJ 189 606) examined whether self-concept variables enhanced predictions about students' participation in school activities, using unstructured stepwise regression techniques. A reanalysis of their data using hierarchial regression models tested their hypothesis more appropriately, and uncovered multicollinearity and…

  11. Fathers' Participation in the Domestic Activities of Everyday Life

    ERIC Educational Resources Information Center

    Romano, Maria Clelia; Bruzzese, Dario

    2007-01-01

    In this paper, the data from the multi-purpose survey on household "Time Use" conducted by Istat (the Italian National Statistical Institute) in 2002-2003 and the data from this same survey conducted in 1988-1989 will be analysed with the purpose of describing the fathers' daily participation in the domestic activities and of highlighting the…

  12. Propagation of Action Potentials: An Active Participation Exercise.

    ERIC Educational Resources Information Center

    Felsten, Gary

    1998-01-01

    Describes an active participation exercise that demonstrates the propagation of action potentials (the ability to transmit information through the neural network, dependent upon chemical interactions in the brain). Students assume the structure and function of the network by lining up around the room and communicating through hand signals and…

  13. Pyrrolnitrin and Hydrogen Cyanide Production by Pseudomonas chlororaphis Strain PA23 Exhibits Nematicidal and Repellent Activity against Caenorhabditis elegans

    PubMed Central

    Nandi, Munmun; Selin, Carrie; Brassinga, Ann Karen C.; Belmonte, Mark F.; Fernando, W. G. Dilantha; Loewen, Peter C.; de Kievit, Teresa R.

    2015-01-01

    Pseudomonas chlororaphis strain PA23 is a biocontrol agent able to suppress growth of the fungal pathogen Sclerotinia sclerotiorum. This bacterium produces an arsenal of exometabolites including pyrrolnitrin (PRN), phenazine (PHZ), hydrogen cyanide (HCN), and degradative enzymes. Production of these compounds is controlled at both the transcriptional and posttranscriptional levels by the Gac-Rsm system, RpoS, PsrA, and the Phz quorum-sensing system. Beyond pathogen-suppression, the success of a biocontrol agent is dependent upon its ability to establish itself in the environment where predation by bacterivorous organisms, including nematodes, may threaten persistence. The focus of this study was to investigate whether PA23 is able to resist grazing by Caenorhabditis elegans and to define the role played by exoproducts in the bacterial-nematode interaction. We discovered that both PRN and HCN contribute to fast- and slow-killing of C. elegans. HCN is well-established as having lethal effects on C. elegans; however, PRN has not been reported to be nematicidal. Exposure of L4 stage nematodes to purified PRN reduced nematode viability in a dose-dependent fashion and led to reduced hatching of eggs laid by gravid adults. Because bacterial metabolites can act as chemoattractants or repellents, we analyzed whether PA23 exhibited attractant or repulsive properties towards C. elegans. Both PRN and HCN were found to be potent repellents. Next we investigated whether the presence of C. elegans would elicit changes in PA23 gene activity. Co-culturing the two organisms increased expression of a number of genes associated with biocontrol, including phzA, hcnA, phzR, phzI, rpoS and gacS. Exoproduct analysis showed that PHZ and autoinducer signals were upregulated, consistent with the gene expression profiles. Collectively, these findings indicate that PA23 is able to sense the presence of C. elegans and it is able to both repel and kill the nematodes, which should facilitate

  14. Factors associated with leisure time physical activity among ELSA-Brasil participants: Ecological model.

    PubMed

    Pitanga, Francisco José Gondim; Matos, Sheila Maria Alvim; Almeida, Maria da Conceição; Molina, Maria Del Carmen Bisi; Aquino, Estela M L

    2016-09-01

    The main objective of the study was identify the prevalence and factors associated with leisure time physical activity (LTPA) in adult participants of the Longitudinal Study of Adult Health (ELSA-Brasil). The LTPA was measured using the International Physical Activity Questionnaire (IPAQ), long version. A hierarchical ecological model was built with the possible factors associated with LTPA distributed across blocks. We estimated crude and adjusted odds ratios (ORs) and 95% confidence intervals (95% CIs) using logistic regression. In men, being more educated, having a high family income, living in environments with conditions and opportunities for PA, being retired and being overweight were positively associated, while current smoking, obesity and abdominal obesity were associated negatively with the LTPA. Among women, being over 60years old, being more educated, having a high family income, living in an environment with conditions and opportunities for PA practice and being retired were positively associated, while being overweight, obese and having abdominal obesity were associated negatively with the LTPA. The proposed ecological model explains the LTPA through the social, physical and personal environment and highlights gender differences in physical activity.

  15. Signalling networks associated with urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 in breast cancer tissues: new insights from protein microarray analysis.

    PubMed

    Wolff, Claudia; Malinowsky, Katharina; Berg, Daniela; Schragner, Kerstin; Schuster, Tibor; Walch, Axel; Bronger, Holger; Höfler, Heinz; Becker, Karl-Friedrich

    2011-01-01

    The urokinase-type plasminogen activator (uPA) and the main uPA inhibitor PAI-1 play important roles in cell migration and invasion in both physiological and pathological contexts. Both factors are clinically applicable predictive markers in node-negative breast cancer patients that are used to stratify patients for adjuvant chemotherapy. In addition to their classical functions in plasmin regulation, both factors are key components in cancer-related cell signalling. Such signalling cascades are well described in cell culture systems, but a better understanding of uPA- and PAI-1-associated signalling networks in clinical tissues is needed. We examined the expression of uPA, PAI-1, and 21 signalling molecules in 201 primary breast cancer tissues using protein microarrays. Expression of uPA was significantly correlated with the expression of ERK and Stat3, while expression of PAI-1 was correlated with the uPA receptor and Akt activation, presumably via integrin and HER-receptor signalling. Analysis of uPA expression did not reveal any significant correlation with staging, grading or age of the patients. The PAI-1 expression was correlated with nodal stage. Network monitoring for uPA and PAI-1 in breast cancer reveals interactions with main signalling cascades and extends the findings from cell culture experiments. Our results reveal possible mechanisms underlying cancer development.

  16. [Participation of pineal gland in antistressor activity of adaptogenic drugs].

    PubMed

    Arushanian, É B; Beĭer, É V

    2015-01-01

    Chronic stress produces some morphological changes in rats, including thymus weight reduction, adrenal hypertrophy, and peptic ulcers in stomach. Repeated administration of phytoadaptogenic drugs (ginseng and bilobil) decreased these stress-induced disorders. The antistressor activity of drugs was attenuated upon by removal of the pineal gland. Histochemical and morphometric investigation of pineal tissues in stressed animals showed that that the pharmacological effect was accompanied by increasing functional activity of the pineal gland. It is suggested that pineal mobilization may participate in antistressor activity of phytoadaptogenic drugs.

  17. [Participation of pineal gland in antistressor activity of adaptogenic drugs].

    PubMed

    Arushanian, É B; Beĭer, É V

    2015-01-01

    Chronic stress produces some morphological changes in rats, including thymus weight reduction, adrenal hypertrophy, and peptic ulcers in stomach. Repeated administration of phytoadaptogenic drugs (ginseng and bilobil) decreased these stress-induced disorders. The antistressor activity of drugs was attenuated upon by removal of the pineal gland. Histochemical and morphometric investigation of pineal tissues in stressed animals showed that that the pharmacological effect was accompanied by increasing functional activity of the pineal gland. It is suggested that pineal mobilization may participate in antistressor activity of phytoadaptogenic drugs. PMID:25826867

  18. Participation of iatrogenically coagulopathic patients in wilderness activities.

    PubMed

    Hawkins, Seth C; Caudell, Michael J; Deloughery, Thomas G; Murray, William

    2013-09-01

    An increasing number of patients routinely undergo long-term anticoagulation with warfarin or other pharmacological agents. There is little evidence and no consensus documents in the literature regarding the appropriateness and relative risk of their participation in wilderness activities. We present a case report, conduct an analysis of the limited literature that is available, and make recommendations for wilderness medicine practitioners and screening personnel.

  19. Specific identification of Lachesis muta muta snake venom using antibodies against the plasminogen activator enzyme, LV-PA.

    PubMed

    Felicori, Liza F; Chávez-Olórtegui, Carlos; Sánchez, Eladio F

    2005-05-01

    Sandwich-type enzyme linked immunosorbent assays (ELISA) were developed to detect Lachesis muta muta (bushmaster) snake venom using antibodies against the plasminogen activator enzyme (LV-PA). Antibodies to LV-PA were obtained by immunization of one rabbit with the purified enzyme. The IgG fraction was purified from rabbit blood in a single step on a column of Sepharose-L. m. muta venom and used to coat the microtiter plates. The specificity of the assay was demonstrated by its capacity to correctly discriminate between the circulating antigens in mice that were experimentally inoculated with L. m. muta venom from those in mice inoculated with venoms from Bothrops atrox, B. brazili, B. castelnaudi, Bothriopsis taeniata, B. bilineata, Crotalus durissus ruruima and the antigenic Bothrops (AgB) and Crotalus (AgC) pools venoms used to produce Bothropic and Crotalic antivenoms at Fundacao Ezequiel Dias (FUNED). Measurable absorbance signals were obtained with 1.5 ng of venom per assay. The ELISA was used to follow the kinetic distribution of antigens in experimentally envenomed mice. PMID:15804530

  20. Progression of Osteosarcoma from a Non-Metastatic to a Metastatic Phenotype Is Causally Associated with Activation of an Autocrine and Paracrine uPA Axis

    PubMed Central

    Endo-Munoz, Liliana; Cai, Na; Cumming, Andrew; Macklin, Rebecca; Merida de Long, Lilia; Topkas, Eleni; Mukhopadhyay, Pamela; Hill, Michelle; Saunders, Nicholas A

    2015-01-01

    Pulmonary metastasis is the major untreatable complication of osteosarcoma (OS) resulting in 10–20% long-term survival. The factors and pathways regulating these processes remain unclear, yet their identification is crucial in order to find new therapeutic targets. In this study we used a multi-omics approach to identify molecules in metastatic and non-metastatic OS cells that may contribute to OS metastasis, followed by validation in vitro and in vivo. We found elevated levels of the urokinase plasminogen activator (uPA) and of the uPA receptor (uPAR) exclusively in metastatic OS cells. uPA was secreted in soluble form and as part of the protein cargo of OS-secreted extracellular vesicles, including exosomes. In addition, in the tumour microenvironment, uPA was expressed and secreted by bone marrow cells (BMC), and OS- and BMC-derived uPA significantly and specifically stimulated migration of metastatic OS cells via uPA-dependent signaling pathways. Silencing of uPAR in metastatic OS cells abrogated the migratory response to uPA in vitro and decreased metastasis in vivo. Finally, a novel small-molecule inhibitor of uPA significantly (P = 0.0004) inhibited metastasis in an orthotopic mouse model of OS. Thus, we show for the first time that malignant conversion of OS cells to a metastatic phenotype is defined by activation of the uPA/uPAR axis in both an autocrine and paracrine fashion. Furthermore, metastasis is driven by changes in OS cells as well as in the microenvironment. Finally, our data show that pharmacological inhibition of the uPA/uPAR axis with a novel small-molecule inhibitor can prevent the emergence of metastatic foci. PMID:26317203

  1. Participant Adherence Indicators Predict Changes in Blood Pressure, Anthropometric Measures, and Self-Reported Physical Activity in a Lifestyle Intervention: HUB City Steps

    ERIC Educational Resources Information Center

    Thomson, Jessica L.; Landry, Alicia S.; Zoellner, Jamie M.; Connell, Carol; Madson, Michael B.; Molaison, Elaine Fontenot; Yadrick, Kathy

    2015-01-01

    The objective of this secondary analysis was to evaluate the utility of several participant adherence indicators for predicting changes in clinical, anthropometric, dietary, fitness, and physical activity (PA) outcomes in a lifestyle intervention, HUB City Steps, conducted in a southern, African American cohort in 2010. HUB City Steps was a…

  2. Caregiver Reports of Children's Activity Participation Following Serious Injury.

    PubMed

    Braaf, Sandra; Ameratunga, Shanthi; Teague, Warwick; Jowett, Helen; Gabbe, Belinda

    2016-01-01

    Paediatric trauma can result in significant levels of on-going disability. The aim of this study was to explore the restrictions on activity participation that children experience following serious injury from the perspective of their caregivers. We performed a thematic analysis of transcripts of semi-structured in-depth interviews with the caregivers of 44 seriously injured children, conducted three-years after the injury, and purposively sampled from a population-based cohort study. Both temporary and on-going restrictions on school, sport, leisure and social activities were identified, some of which were imposed by caregivers, schools, or recommended by health providers. The perceived risk of further injury, physical restrictions, emotional state and fatigue levels were important influences on degrees of activity restriction. Children who were socially less engaged, especially those who were more severely injured, had difficulty making and retaining friends, and exhibited signs of depression or social withdrawal. The activities of pre-school children were strongly regulated by their caregivers, while school age children faced obstacles with participation in aspects such as study, sport, and peer and teacher relationships, affecting learning, school attendance and enjoyment. The findings highlight the need for primary prevention and reducing the impacts of serious injury throughout the continuum of care. PMID:27399741

  3. Relationship between participation in leisure activities and constraints on Taiwanese breastfeeding mothers during leisure activities

    PubMed Central

    2013-01-01

    Background Participation in leisure activities strongly associates with health and well-being. Little research has explored the relationship between participation in leisure activities and constraints on breastfeeding mothers during leisure activities. The purposes of this study are: 1) to investigate constraints on breastfeeding mothers during leisure activities and participation in leisure activities; 2) to investigate the differences between preferences for leisure activities and actual participation by breastfeeding mothers; 3) to segment breastfeeding mothers with similar patterns, using a cluster analysis based on the delineated participation in leisure activities and leisure preferences; 4) to explore any differences between clusters of breastfeeding mothers with respect to socio-demographic characteristics, breastfeeding behaviours and leisure constraints. Methods This study has a cross-sectional design using an online survey conducted among mothers having breastfeeding experiences of more than four months. The questionnaire includes demographic variables, breastfeeding behaviours, preferences for leisure activities participation, and constraints on leisure activities. Collection of data occurred between March and July 2011, producing 415 valid responses for analysis. Results For breastfeeding mothers, this study identifies constraints on breastfeeding related to leisure activities in addition to the three traditional factors for constraints in the model. This study demonstrates that reports of constraints related to children, family, and nursing environments are the most frequent. Breastfeeding mothers in Taiwan participate regularly in family activities or activities related to their children. Cluster analysis classified breastfeeding mothers into Action and Contemplation groups, and found that mothers within the latter group participate less in leisure activities and experienced more constraints related to breastfeeding. Conclusions Implications provide

  4. Prognostic value of tissue-type plasminogen activator (tPA) and its complex with the type-1 inhibitor (PAI-1) in breast cancer

    PubMed Central

    Witte, J H de; Sweep, C G J; Klijn, J G M; Grebenschikov, N; Peters, H A; Look, M P; Tienoven, ThH van; Heuvel, J J T M; Vries, J Bolt-De; Benraad, ThJ; Foekens, J A

    1999-01-01

    The prognostic value of tissue-type plasminogen activator (tPA) measured in samples derived from 865 patients with primary breast cancer using a recently developed enzyme-linked immunosorbent assay (ELISA) was evaluated. Since the assay could easily be adapted to the assessment of the complex of tPA with its type-1 inhibitor (PAI-1), it was investigated whether the tPA:PAI-1 complex also provides prognostic information. To this end, cytosolic extracts and corresponding detergent extracts of 100 000 g pellets obtained after ultracentrifugation when preparing the cytosolic fractions for routine steroid hormone receptor determination were assayed. Statistically significant correlations were found between the cytosolic levels and those determined in the pellet extracts (Spearman correlation coefficient rs = 0.75, P < 0.001 for tPA and r = 0.50, P < 0.001 for tPA:PAI-1 complex). In both Cox univariate and multivariate analysis elevated levels of (total) tPA determined in the pellet extracts, but not in cytosols, were associated with prolonged relapse-free (RFS) and overall survival (OS). In contrast, high levels of the tPA:PAI-1 complex measured in cytosols, but not in the pellet extracts, were associated with a poor RFS and OS. The prognostic information provided by the cytosolic tPA:PAI-1 complex was comparable to that provided by cytosolic (total) PAI-1. Furthermore, the estimated levels of free, uncomplexed tPA and PAI-1, in cytosols and in pellet extracts, were related to patient prognosis in a similar way as the (total) levels of tPA and PAI-1 respectively. Determination of specific forms of components of the plasminogen activation system, i.e. tPA:PAI-1 complex and free, uncomplexed tPA and/or PAI-1, may be considered a useful adjunct to the analyses of the separate components (tPA and/or PAI-1) and provide valuable additional prognostic information with respect to survival of breast cancer patients. © 1999 Cancer Research Campaign PMID:10390010

  5. Putting Activism in Its Place: The Neighborhood Context of Participation in Neighborhood-Focused Activism.

    PubMed

    Gilster, Megan E

    2014-02-01

    Neighborhood-focused activism is one way residents enact their vision for their community. This study examines the neighborhood socioeconomic antecedents of participation in neighborhood-focused activism in a diverse sample of residents of Chicago neighborhoods to test three theories of neighborhood socioeconomic context and participation: 1) affluence affords participation, 2) activism addresses neighborhood needs associated with disadvantage, and 3) socioeconomic inequality creates contention that necessitates participation. Measuring neighborhood socioeconomic status as two unique dimensions, neighborhood affluence and neighborhood disadvantage, and accounting for both individual and neighborhood characteristics, I find support for each theory. Neighborhood socioeconomic context matters for participation, regardless of individual socioeconomic characteristics. Only when these three perspectives are considered jointly can they fully capture the socioeconomic context of participation in neighborhood-focused activism.

  6. What Young People Say about Physical Activity: The Children's Sport Participation and Physical Activity (CSPPA) Study

    ERIC Educational Resources Information Center

    Tannehill, Deborah; MacPhail, Ann; Walsh, Julia; Woods, Catherine

    2015-01-01

    The Children's Sport Participation and Physical Activity (CSPPA) study is a unique multi-centre/discipline study undertaken by three Irish institutions, Dublin City University, University of Limerick and University College Cork. The study sought to assess participation in physical activity, physical education and sport (PAPES) among 10-18 year…

  7. Enhancement of t-PA-mediated plasminogen activation by partially defucosylated glycosaminoglycans from the sea cucumber Stichopus japonicus.

    PubMed

    Kariya, Yutaka; Sakai, Tokiko; Kaneko, Takuji; Suzuki, Kiyoshi; Kyogashima, Mamoru

    2002-08-01

    Sea cucumber glycosaminoglycan (SC-GAG) was isolated from the body wall of the sea cucumber Stichopus japonicus. The SC-GAG consists of a chondroitin sulfate E-type core polymer with sulfated fucose branches attaching glycosidically to almost every disaccharide unit of the core polymer at the C-3 position of the GlcA or at C-4 and/or C-6 position(s) of GalNAc. SC-GAG was subjected to mild acid-hydrolysis, which cleaved selectively the glycosidic linkages between the core polymer and the fucose branches, resulting in two types of partially defucosylated SC-GAG derivatives. One type (type A), obtained by 3 h-hydrolysis, contained 33% of the fucose branches and the other type (type B), obtained by 6-h hydrolysis, contained 10% of the fucose branches. The molecular masses of types A and B were determined to be 8 and 4 kDa, respectively, by gel permeation HPLC. A chondroitinase ABC (Chase ABC)-digestion demonstrated that types A and B contained 46 and 66% of digestable disaccharide units, respectively, and both types contained 29% of E-type unsaturated disaccharide units bearing no fucose branches. Intact SC-GAG and types A and B were compared for t-PA-mediated plasminogen activation by an in vitro assay system. Although intact SC-GAG and type B exhibited rather weak activity at 6.25 microg/ml, type A exhibited 5 to 10-fold higher activity than intact SC-GAG and type B at the same concentration. The activity of type A was almost one-third that of purified chondroitin sulfate E (127 kDa containing 64.5% E-type disaccharide units) from squid cartilage at 6.25 microg/ml concentration. These results suggest that t-PA-mediated plasminogen activation requires the presence of E-type disaccharide units bearing no fucose branches and a molecular mass larger than 7.5 kDa in terms of the chondroitin sulfate E structure with or without fucose branching.

  8. Inter-participant variability in daily physical activity and sedentary time among male youth sport footballers: independent associations with indicators of adiposity and cardiorespiratory fitness.

    PubMed

    Fenton, Sally A M; Duda, Joan L; Barrett, Timothy

    2016-01-01

    Participation in youth sport is assumed to promote and contribute towards more physically active lifestyles among children and adolescents. The aim of this study was to examine inter-participant variability in objectively measured habitual physical activity (PA) behaviours and sedentary time among youth sport participants and their implications for health. One-hundred-and-eighteen male youth sport footballers (Mean ± s = 11.72 ± 1.60) wore a GT3X accelerometer for 7 days. Average daily PA [min · day(-1), in light (LPA), moderate (MPA), vigorous (VPA) and combined moderate-to-vigorous (MVPA)] and sedentary time were calculated. Participants' body mass index adjusted for age and sex (BMI-standard deviation score), per cent body fat (BF%), waist circumference and cardiorespiratory fitness were assessed. Results revealed that variability in daily PA behaviours and sedentary time (min · day(-1)) was associated with BMI-standard deviation score [VPA (-), MVPA (-)], BF% [sedentary time (+), VPA (-), MVPA (-)], waist circumference [sedentary time (+), LPA (-)] and cardiorespiratory fitness [sedentary time (-), MPA (+), VPA (+), MVPA (+)]. Whilst sedentary time and MVPA were not related to health outcomes independent of one another, associations with markers of adiposity and cardiorespiratory fitness were stronger for sedentary time. Sedentary time was also significantly positively related to waist circumference independent of VPA. Results demonstrate inter-participant variability in habitual PA and sedentary time among youth sport participants which holds implications for their health. Thus, promoting PA and, in particular, reducing sedentary time may contribute towards the prevention of adverse health consequences associated with a physically inactive lifestyle for children and adolescents active in the youth sport context.

  9. Preparing students to participate in an active learning environment.

    PubMed

    Modell, H I

    1996-06-01

    Most students have spent the majority of their school career in passive learning environments in which faculty were disseminators of information, and students were required to memorize information or use specified algorithms to "solve problems." In an active learning environment, students are encouraged to engage in the process of building and testing their own mental models from information that they are acquiring. In such a learner-centered environment, faculty become facilitators of learning, and students become active participants, engaging in a dialogue with their colleagues and with the instructor. To create a successful active learning environment, both faculty and students must make adjustments to what has been their respective "traditional" roles in the classroom. For the instructor who is committed to promoting active learning, the challenge lies in helping students understand the necessity of becoming active colleagues in learning. This process can be facilitated if the curriculum includes exercises to direct students' attention to a number of issues that impact their learning. This paper describes four such exercises designed to help students form appropriate course expectations, recognize the need for seeking clarification when communicating, recognize the role of personal experience in building mental models, and become familiar with study aids for building formal models.

  10. Reduction in ATP levels triggers immunoproteasome activation by the 11S (PA28) regulator during early antiviral response mediated by IFNβ in mouse pancreatic β-cells.

    PubMed

    Freudenburg, Wieke; Gautam, Madhav; Chakraborty, Pradipta; James, Jared; Richards, Jennifer; Salvatori, Alison S; Baldwin, Aaron; Schriewer, Jill; Buller, R Mark L; Corbett, John A; Skowyra, Dorota

    2013-01-01

    Autoimmune destruction of insulin producing pancreatic β-cells is the hallmark of type I diabetes. One of the key molecules implicated in the disease onset is the immunoproteasome, a protease with multiple proteolytic sites that collaborates with the constitutive 19S and the inducible 11S (PA28) activators to produce immunogenic peptides for presentation by MHC class I molecules. Despite its importance, little is known about the function and regulation of the immunoproteasome in pancreatic β-cells. Of special interest to immunoproteasome activation in β-cells are the effects of IFNβ, a type I IFN secreted by virus-infected cells and implicated in type I diabetes onset, compared to IFNγ, the classic immunoproteasome inducer secreted by cells of the immune system. By qPCR analysis, we show that mouse insulinoma MIN6 cells and mouse islets accumulate the immune proteolytic β1(i), β2(i) and β5(i), and 11S mRNAs upon exposure to IFNβ or IFNγ. Higher concentrations of IFNβ than IFNγ are needed for similar expression, but in each case the expression is transient, with maximal mRNA accumulation in 12 hours, and depends primarily on Interferon Regulatory Factor 1. IFNs do not alter expression of regular proteasome genes, and in the time frame of IFNβ-mediated response, the immune and regular proteolytic subunits co-exist in the 20S particles. In cell extracts with ATP, these particles have normal peptidase activities and degrade polyubiquitinated proteins with rates typical of the regular proteasome, implicating normal regulation by the 19S activator. However, ATP depletion rapidly stimulates the catalytic rates in a manner consistent with levels of the 11S activator. These findings suggest that stochastic combination of regular and immune proteolytic subunits may increase the probability with which unique immunogenic peptides are produced in pancreatic β-cells exposed to IFNβ, but primarily in cells with reduced ATP levels that stimulate the 11S

  11. Allelic imbalance of tissue-type plasminogen activator (t-PA) gene expression in human brain tissue.

    PubMed

    Tjarnlund-Wolf, A; Hultman, K; Curtis, M A; Faull, R L M; Medcalf, R L; Jern, C

    2011-06-01

    We have identified a single-nucleotide polymorphism (SNP) in the t-PA enhancer (-7351C>T), which is associated with endothelial t-PA release in vivo. In vitro studies demonstrated that this SNP is functional at the level of transcription. In the brain, t-PA has been implicated in both physiologic and pathophysiologic processes. The aim of the present study was to examine the effect of the t-PA -7351C>T SNP on t-PA gene expression in human brain tissue. Allelic mRNA expression was measured in heterozygous post-mortem brain tissues using quantitative TaqMan genotyping assay. Protein-DNA interactions were assessed using electrophoretic mobility shift assay (EMSA) and chromatin immunoprecipitation (ChIP). Significantly higher levels of t-PA mRNA were generated from chromosomes that harboured the wild-type -7351C allele, as compared to those generated from the mutant T allele (for the hippocampus, C to T allelic ratio of ~1.3, p=0.010, n=12; and for the cortex, C to T allelic ratio of ~1.2, p=0.017, n=12). EMSA showed reduced neuronal and astrocytic nuclear protein binding affinity to the T allele, and identified Sp1 and Sp3 as the major transcription factors that bound to the -7351 site. ChIP analyses confirmed that Sp1 recognises this site in intact cells. In conclusion, the t-PA -7351C>T SNP affects t-PA gene expression in human brain tissue. This finding might have clinical implications for neurological conditions associated with enhanced t-PA levels, such as in the acute phase of cerebral ischaemia, and also for stroke recovery.

  12. A novel small-molecule inhibitor of influenza A virus acts by suppressing PA endonuclease activity of the viral polymerase

    PubMed Central

    Yuan, Shuofeng; Chu, Hin; Singh, Kailash; Zhao, Hanjun; Zhang, Ke; Kao, Richard Y. T.; Chow, Billy K. C.; Zhou, Jie; Zheng, Bo-Jian

    2016-01-01

    The RNA-dependent RNA polymerase of influenza A virus comprises conserved and independently-folded subdomains with defined functionalities. The N-terminal domain of the PA subunit (PAN) harbors the endonuclease function so that it can serve as a desired target for drug discovery. To identify a class of anti-influenza inhibitors that impedes PAN endonuclease activity, a screening approach that integrated the fluorescence resonance energy transfer based endonuclease inhibitory assay with the DNA gel-based endonuclease inhibitory assay was conducted, followed by the evaluation of antiviral efficacies and potential cytotoxicity of the primary hits in vitro and in vivo. A small-molecule compound ANA-0 was identified as a potent inhibitor against the replication of multiple subtypes of influenza A virus, including H1N1, H3N2, H5N1, H7N7, H7N9 and H9N2, in cell cultures. Combinational treatment of zanamivir and ANA-0 exerted synergistic anti-influenza effect in vitro. Intranasal administration of ANA-0 protected mice from lethal challenge and reduced lung viral loads in H1N1 virus infected BALB/c mice. In summary, ANA-0 shows potential to be developed to novel anti-influenza agents. PMID:26956222

  13. Characteristic amino acid changes of influenza A(H1N1)pdm09 virus PA protein enhance A(H7N9) viral polymerase activity.

    PubMed

    Liu, Jun; Huang, Feng; Zhang, Junsong; Tan, Likai; Lu, Gen; Zhang, Xu; Zhang, Hui

    2016-06-01

    Human coinfection with a novel H7N9 influenza virus and the 2009 pandemic A(H1N1) influenza virus, H1N1pdm09, has recently been reported in China. Because reassortment can occur during coinfection, it is necessary to clarify the effects of gene reassortment between these two viruses. Among the viral ribonucleoprotein complex (vRNP) genes, only the PA gene of H1N1pdm09 enhances the avian influenza viral polymerase activity. Based on a phylogenetic analysis, we show a special evolutionary feature of the H1N1pdm09 PA gene, which clustered with those of the novel H7N9 virus and related H9N2 viruses, rather than in the outgroup as the H1N1pdm09 genes do on the phylogenetic trees of other vRNP genes. Using a minigenome system of the novel H7N9 virus, we further demonstrate that replacement of its PA gene significantly enhanced its polymerase activity, whereas replacement of the other vRNP genes reduced its polymerase activity. We also show that the residues of PA evolutionarily conserved between H1N1pdm09 and the novel H7N9 virus are associated with attenuated or neutral polymerase activity. The mutations associated with the increased activity of the novel H7N9 polymerase are characteristic of the H1N1pdm09 gene, and are located almost adjacent to the surface of the PA protein. Our results suggest that the novel H7N9 virus has more effective PB1, PB2, and NP genes than H1N1pdm09, and that H1N1pdm09-like PA mutations enhance the novel H7N9 polymerase function.

  14. Asthma and Rhinitis Are Associated with Less Objectively-Measured Moderate and Vigorous Physical Activity, but Similar Sport Participation, in Adolescent German Boys: GINIplus and LISAplus Cohorts

    PubMed Central

    Berdel, Dietrich; Bauer, Carl-Peter; Koletzko, Sibylle; Nowak, Dennis; Heinrich, Joachim; Schulz, Holger

    2016-01-01

    Introduction Physical activity (PA) protects against most noncommunicable diseases and has been associated with decreased risk of allergic phenotype, which is increasing worldwide. However, the association is not always present; furthermore it is not clear whether it is strongest for asthma, rhinitis, symptoms of these, or atopic sensitization; which sex is most affected; or whether it can be explained by either avoidance of sport or exacerbation of symptoms by exercise. Interventions are thus difficult to target. Methods PA was measured by one-week accelerometry in 1137 Germans (mean age 15.6 years, 47% boys) from the GINIplus and LISAplus birth cohorts, and modeled as a correlate of allergic symptoms, sensitization, or reported doctor-diagnosed asthma or rhinitis. Results 8.3% of children had asthma, of the remainder 7.9% had rhinitis, and of the remainder 32% were sensitized to aero-allergens (atopic). 52% were lung-healthy controls. Lung-healthy boys and girls averaged 46.4 min and 37.8 min moderate-to-vigorous PA per day, of which 14.6 and 11.4 min was vigorous. PA in allergic girls was not altered, but boys with asthma got 13% less moderate and 29% less vigorous PA, and those with rhinitis with 13% less moderate PA, than lung-healthy boys. Both sexes participated comparably in sport (70 to 84%). Adolescents with wheezing (up to 68%, in asthma) and/or nose/eye symptoms (up to 88%, in rhinitis) were no less active. Conclusions We found that asthma and rhinitis, but not atopy, were independently associated with low PA in boys, but not in girls. These results indicate that allergic boys remain a high-risk group for physical inactivity even if they participate comparably in sport. Research into the link between PA and allergy should consider population-specific and sex-specific effects, and clinicians, parents, and designers of PA interventions should specifically address PA in allergic boys to ensure full participation. PMID:27560942

  15. Maduramicin Rapidly Eliminates Malaria Parasites and Potentiates the Gametocytocidal Activity of the Pyrazoleamide PA21A050

    PubMed Central

    Maron, Maxim I.; Magle, Crystal T.; Czesny, Beata; Turturice, Benjamin A.; Huang, Ruili; Zheng, Wei; Vaidya, Akhil B.

    2015-01-01

    New strategies targeting Plasmodium falciparum gametocytes, the sexual-stage parasites that are responsible for malaria transmission, are needed to eradicate this disease. Most commonly used antimalarials are ineffective against P. falciparum gametocytes, allowing patients to continue to be infectious for over a week after asexual parasite clearance. A recent screen for gametocytocidal compounds demonstrated that the carboxylic polyether ionophore maduramicin is active at low nanomolar concentrations against P. falciparum sexual stages. In this study, we showed that maduramicin has an EC50 (effective concentration that inhibits the signal by 50%) of 14.8 nM against late-stage gametocytes and significantly blocks in vivo transmission in a mouse model of malaria transmission. In contrast to other reported gametocytocidal agents, maduramicin acts rapidly in vitro, eliminating gametocytes and asexual schizonts in less than 12 h without affecting uninfected red blood cells (RBCs). Ring stage parasites are cleared by 24 h. Within an hour of drug treatment, 40% of the normally crescent-shaped gametocytes round up and become spherical. The number of round gametocytes increases to >60% by 2 h, even before a change in membrane potential as monitored by MitoProbe DiIC1 (5) is detectable. Maduramicin is not preferentially taken up by gametocyte-infected RBCs compared to uninfected RBCs, suggesting that gametocytes are more sensitive to alterations in cation concentration than RBCs. Moreover, the addition of 15.6 nM maduramicin enhanced the gametocytocidal activity of the pyrazoleamide PA21A050, which is a promising new antimalarial candidate associated with an increase in intracellular Na+ concentration that is proposed to be due to inhibition of PfATP4, a putative Na+ pump. These results underscore the importance of cation homeostasis in sexual as well as asexual intraerythrocytic-stage P. falciparum parasites and the potential of targeting this pathway for drug development

  16. Participant adherence indicators predict changes in blood pressure, anthropometric measures, and self-reported physical activity in a lifestyle intervention: HUB city steps.

    PubMed

    Thomson, Jessica L; Landry, Alicia S; Zoellner, Jamie M; Connell, Carol; Madson, Michael B; Molaison, Elaine Fontenot; Yadrick, Kathy

    2015-02-01

    The objective of this secondary analysis was to evaluate the utility of several participant adherence indicators for predicting changes in clinical, anthropometric, dietary, fitness, and physical activity (PA) outcomes in a lifestyle intervention, HUB City Steps, conducted in a southern, African American cohort in 2010. HUB City Steps was a 6-month, community-engaged, multicomponent, noncontrolled intervention targeting hypertension risk factors. Descriptive indicators were constructed using two participant adherence measures, education session attendance (ESA) and weekly steps/day pedometer diary submission (PDS), separately and in combination. Analyses, based on data from 269 primarily African American adult participants, included bivariate tests of association and multivariable linear regression to determine significant relationships between seven adherence indicators and health outcome changes, including clinical, anthropometric, dietary, fitness, and PA measures. ESA indicators were significantly correlated with four health outcomes: body mass index (BMI), fat mass, low-density lipoprotein (LDL), and PA (-.29 ≤ r ≤ .23, p < .05). PDS indicators were significantly correlated with PA (r = .27, p < .001). Combination ESA/PDS indicators were significantly correlated with five health outcomes: BMI, percentage body fat (%BF), fat mass, LDL, and PA (r = -.26 to .29, p < .05). Results from the multivariate models indicated that the combination ESA/PDS indicators were the most significant predictors of changes for five outcomes--%BF, fat mass, LDL diastolic blood pressure (DBP), and PA--while ESA performed best for BMI only. For DBP, a one-unit increase in the continuous-categorical ESA/PDS indicator resulted in 0.3 mm Hg decrease. Implications for assessing participant adherence in community-based, multicomponent lifestyle intervention research are discussed.

  17. Oxidation of Gas-Phase Protactinium Ions, Pa+ and Pa2+: Formation and Properties of PaO22+(g), Protactinyl

    SciTech Connect

    Santos, M.; de Matos, A. Pires; Marcalo, J.; Gibson, John K; Haire, Richard {Dick} G; Tyagi, R.; Pitzer, R. M.

    2006-01-01

    Oxidation reactions of bare and ligated, monopositive, and dipositive Pa ions in the gas phase were studied by Fourier transform ion cyclotron resonance mass spectrometry. Seven oxidants were employed, ranging from the thermodynamically robust N{sub 2}O to the relatively weak CH{sub 2}O - all oxidized Pa{sup +} to PaO{sup +} and PaO{sup +} to PaO{sub 2}{sup +}. On the basis of experimental observations, it was established that D[Pa{sup +}-O] and D[OPa{sup +}-O] {ge} 751 kJ mol{sup -1}. Estimates for D[Pa{sup +}-O], D[OPa{sup +}-O], IE[PaO], and IE[PaO{sub 2}] were also obtained. The seven oxidants reacted with Pa{sup 2+} to produce PaO{sup 2+}, indicating that D[Pa{sup 2+}-O] {ge} 751 kJ mol{sup -1}. A particularly notable finding was the oxidation of PaO{sup 2+} by N{sub 2}O to PaO{sub 2}{sup 2+}, a species, which formally comprises Pa(VI). Collision-induced dissociation of PaO{sub 2}{sup 2+} suggested the protactinyl connectivity, {l_brace}O-Pa-O{r_brace}{sup 2+}. The experimentally determined IE[PaO{sub 2}{sup +}] {approx} 16.6 eV is in agreement with self-consistent-field and configuration interaction calculations for PaO{sub 2}{sup +} and PaO{sub 2}{sup 2+}. These calculations provide insights into the electronic structures of these ions and indicate the participation of 5f orbitals in bonding and a partial '6p hole' in the case of protactinyl. It was found that PaO{sub 2}{sup 2+} catalyzes the oxidation of CO by N{sub 2}O - such O atom transport via a dipositive metal oxide ion is distinctive. It was also observed that PaO{sub 2}{sup 2+} is capable of activating H{sub 2} to form the stable PaO{sub 2}H{sup 2+} ion.

  18. Adults' Participation in Informal Learning Activities: Key Findings from the Adult Education Participation Survey in Taiwan

    ERIC Educational Resources Information Center

    Lai, Horng-Ji; Wu, Ming-Lieh; Li, Ai-Tzu

    2011-01-01

    This study investigated the informal learning experiences expressed by Taiwanese adults (aged from 16 to 97) and examined their involvement related to selected socio-demographic characteristics. Data of the 2008 Adult Education Participation Survey in Taiwan and Fujian Area were used to look at different variables of adults' demographic…

  19. Monsters, Bananas and Seaweed: Active Participation and Young Children's Understanding of False Belief.

    ERIC Educational Resources Information Center

    Szarkowicz, Diane Louise

    This study investigated the effect of active participation in a story reading on children's understanding of false belief. Children, ages 38-63 months, were assigned to a participation or non-participation group. Participating children engaged in a book-reading process using puppets to respond to the story. Non-participating children were read the…

  20. Patterns of Adolescents' Participation in Organized Activities: Are Sports Best when Combined with Other Activities?

    ERIC Educational Resources Information Center

    Linver, Miriam R.; Roth, Jodie L.; Brooks-Gunn, Jeanne

    2009-01-01

    Although many adolescents participate in sports and other types of organized activities, little extant research explores how youth development outcomes may vary for youth involved in different combinations of activities. The present study uses the Child Development Supplement of the Panel Study of Income Dynamics, a large, nationally…

  1. The Meaningful Activity Participation Assessment: A Measure of Engagement in Personally Valued Activities

    ERIC Educational Resources Information Center

    Eakman, Aaron M.; Carlson, Mike E.; Clark, Florence A.

    2010-01-01

    The Meaningful Activity Participation Assessment (MAPA), a recently developed 28-item tool designed to measure the meaningfulness of activity, was tested in a sample of 154 older adults. The MAPA evidenced a sufficient level of internal consistency and test-retest reliability and correlated as theoretically predicted with the Life Satisfaction…

  2. Katimavik Participant's Manual, Book IX, Active Leisure = Katimavik manuel du participant, cahier IX, loisirs actifs.

    ERIC Educational Resources Information Center

    Crelinsten, Michael, Ed.

    The bilingual student manual, devoted to the active leisure learning activity portion of Katimavik (the nine-month volunteer community service and experiential learning program for 17 to 21 year old Canadians) contains sections on learning program objectives and trimester guidelines; optional activities; resume recordkeeping; general information…

  3. The Effect of Multilingual Facilitation on Active Participation in MOOCs

    ERIC Educational Resources Information Center

    Colas, Jean-François; Sloep, Peter B.; Garreta-Domingo, Muriel

    2016-01-01

    A new approach for overcoming the language and culture barriers to participation in Massive Open Online Courses (MOOCs) is reported. It is hypothesised that the juxtaposition of English as the "language of instruction," used for interacting with course materials, and one's preferred language as the "language of participation,"…

  4. 17 CFR 242.101 - Activities by distribution participants.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... passive market maker, that total less than 2% of the ADTV of the security being purchased, or unaccepted... distribution participant or an affiliate of the distribution participant; or (2) Investment grade... that signifies investment grade; or (3) Exempted securities. “Exempted securities” as defined...

  5. 17 CFR 242.101 - Activities by distribution participants.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... passive market maker, that total less than 2% of the ADTV of the security being purchased, or unaccepted... distribution participant or an affiliate of the distribution participant; or (2) Investment grade... that signifies investment grade; or (3) Exempted securities. “Exempted securities” as defined...

  6. Regulation of the sacPA operon of Bacillus subtilis: identification of phosphotransferase system components involved in SacT activity.

    PubMed

    Arnaud, M; Vary, P; Zagorec, M; Klier, A; Debarbouille, M; Postma, P; Rapoport, G

    1992-05-01

    The sacT gene which controls the sacPA operon of Bacillus subtilis encodes a polypeptide homologous to the B. subtilis SacY and the Escherichia coli BglG antiterminators. Expression of the sacT gene is shown to be constitutive. The DNA sequence upstream from sacP contains a palindromic sequence which functions as a transcriptional terminator. We have previously proposed that SacT acts as a transcriptional antiterminator, allowing transcription of the sacPA operon. In strains containing mutations inactivating ptsH or ptsI, the expression of sacPA and sacB is constitutive. In this work, we show that this constitutivity is due to a fully active SacY antiterminator. In the wild-type sacT+ strain or in the sacT30 mutant, SacT requires both enzyme I and HPr of the phosphotransferase system (PTS) for antitermination. It appears that the PTS exerts different effects on the sacB gene and the sacPA operon. The general proteins of the PTS are not required for the activity of SacY while they are necessary for SacT activity. PMID:1577686

  7. Patterns of adolescents' participation in organized activities: are sports best when combined with other activities?

    PubMed

    Linver, Miriam R; Roth, Jodie L; Brooks-Gunn, Jeanne

    2009-03-01

    Although many adolescents participate in sports and other types of organized activities, little extant research explores how youth development outcomes may vary for youth involved in different combinations of activities. The present study uses the Child Development Supplement of the Panel Study of Income Dynamics, a large, nationally representative sample, to compare activity patterns of adolescents ages 10-18 years (n = 1,711). A cluster analytic technique revealed 5 activity clusters: sports-focused, sports plus other activities, primarily school-based activities, primarily religious youth groups, and low activity involvement. Activity patterns were examined in conjunction with 5 categories of youth development outcomes, including competence (e.g., academic ability), confidence (e.g., self-concept of ability), connections (e.g., talking with friends), character (e.g., externalizing behavior problems), and caring (e.g., prosocial behavior). Results showed that those who participated only in sports had more positive outcomes compared with those who had little or no involvement in organized activities, but less positive outcomes compared with those who participated in sports plus other activities.

  8. Evaluating the effects of the Lunchtime Enjoyment Activity and Play (LEAP) school playground intervention on children’s quality of life, enjoyment and participation in physical activity

    PubMed Central

    2014-01-01

    Background An emerging public health strategy is to enhance children’s opportunities to be physically active during school break periods. The aim of this study was to evaluate the effects of the Lunchtime Enjoyment Activity and Play (LEAP) school playground intervention on primary school children’s quality of life (QOL), enjoyment and participation in physical activity (PA). Methods This study consisted of a movable/recycled materials intervention that included baseline, a 7-week post-test and an 8-month follow-up data collection phase. Children within an intervention school (n = 123) and a matched control school (n = 152) aged 5-to-12-years-old were recruited for the study. Children’s PA was measured using a combination of pedometers and direct observation (SOPLAY). Quality of life, enjoyment of PA and enjoyment of lunchtime activities were assessed in the 8-12 year children. A multi-level mixed effect linear regression model was applied in STATA (version 12.0) using the xtmixed command to fit linear mixed models to each of the variables to examine whether there was a significant difference (p < 0.05) between the intervention and control school at the three time points (pre, post and follow-up). Results Significant overall interaction effects (group × time) were identified for children’s mean steps and distance (pedometers) in the intervention school compared to the control school. Intervention school children also spent significantly higher proportions within specified target areas engaged in higher PA intensities in comparison to the control school at both the 7-week post-test and 8-month follow-up. A short-term treatment effect was revealed after 7-weeks for children’s physical health scale QOL, enjoyment of PA and enjoyment of intra-personal play activities. Conclusions Examining the effects of this school playground intervention over a school year suggested that the introduction of movable/recycled materials can have a significant

  9. Participation of Children with and without Disabilities in Social, Recreational and Leisure Activities

    ERIC Educational Resources Information Center

    Solish, Abbie; Perry, Adrienne; Minnes, Patricia

    2010-01-01

    Background: One method of promoting children's friendship development is through activity participation with peers. However, children with disabilities seem to engage in fewer of these activities, and when they do participate often do so primarily with adults. Materials and Methods: This study compared activity participation and friendship in…

  10. Prognostic impact of urokinase-type plasminogen activator (uPA) and its inhibitor (PAI-1) in cytosols and pellet extracts derived from 892 breast cancer patients

    PubMed Central

    de Witte, J H; Sweep, C G J; Klijn, J G M; Grebenschikov, N; Peters, H A; Look, M P; van Tienoven, Th H; Heuvel, J J T M; van Putten, W L J; Benraad, Th J; Foekens, J A

    1999-01-01

    To evaluate the clinical relevance of urokinase-type plasminogen activator (uPA) and its type-1 inhibitor (PAI-1) measured by a recently developed enzyme-linked immunosorbent assay (ELISA), we analysed both components in samples derived from 892 patients with primary breast cancer (median follow-up 99 months). The assays were performed in cytosolic extracts as well as in corresponding detergent extracts of pellets obtained after ultracentrifugation, which was carried out when preparing the cytosolic fractions for routine steroid hormone receptor determination. Statistically significant correlations were found between the cytosolic levels and those determined in the pellet extracts (Spearman correlation coefficient rs = 0.60, P < 0.0001 for uPA and rs = 0.65, P < 0.0001 for PAI-1). Furthermore, strong correlations were found between the levels of both uPA (rs = 0.85, P < 0.0001) and PAI-1 (rs = 0.90, P < 0.0001) in the cytosols and their levels previously measured with ELISAs based on commercial reagents. In both Cox univariate and multivariate analysis, high cytosolic levels of uPA or PAI-1 were significantly associated with increased rates of relapse and death. The levels of uPA and PAI-1 in the pellet extracts also provided prognostic information, although to a lesser extent compared with the cytosolic extracts. The prediction of prognosis on the basis of uPA and PAI-1 assessed by an alternative ELISA once again emphasizes the established prognostic role and usefulness of these parameters in selection of breast cancer patients at high or low risk of recurrence. © 1999 Cancer Research Campaign PMID:10098758

  11. Differential roles of the COOH termini of AAA subunits of PA700 (19 S regulator) in asymmetric assembly and activation of the 26 S proteasome.

    PubMed

    Gillette, Thomas G; Kumar, Brajesh; Thompson, David; Slaughter, Clive A; DeMartino, George N

    2008-11-14

    The 26 S proteasome is an energy-dependent protease that degrades proteins modified with polyubiquitin chains. It is assembled from two multi-protein subcomplexes: a protease (20 S proteasome) and an ATPase regulatory complex (PA700 or 19 S regulatory particle) that contains six different AAA family subunits (Rpt1 to -6). Here we show that binding of PA700 to the 20 S proteasome is mediated by the COOH termini of two (Rpt2 and Rpt5) of the six Rpt subunits that constitute the interaction surface between the subcomplexes. COOH-terminal peptides of either Rpt2 or Rpt5 bind to the 20 S proteasome and activate hydrolysis of short peptide substrates. Simultaneous binding of both COOH-terminal peptides had additive effects on peptide substrate hydrolysis, suggesting that they bind to distinct sites on the proteasome. In contrast, only the Rpt5 peptide activated hydrolysis of protein substrates. Nevertheless, the COOH-terminal peptide of Rpt2 greatly enhanced this effect, suggesting that proteasome activation is a multistate process. Rpt2 and Rpt5 COOH-terminal peptides cross-linked to different but specific subunits of the 20 S proteasome. These results reveal critical roles of COOH termini of Rpt subunits of PA700 in the assembly and activation of eukaryotic 26 S proteasome. Moreover, they support a model in which Rpt subunits bind to dedicated sites on the proteasome and play specific, nonequivalent roles in the asymmetric assembly and activation of the 26 S proteasome.

  12. Intensity of Participation in Organized Youth Activities during the High School Years: Longitudinal Associations with Adjustment

    ERIC Educational Resources Information Center

    Denault, Anne-Sophie; Poulin, Francois; Pedersen, Sara

    2009-01-01

    The goal of this study was to explore the longitudinal associations between youth activity participation and adjustment over the high school years by examining (a) correlations between participation and adjustment growth curves, and (b) bidirectional links between participation and adjustment from one year to the next. Participation was…

  13. Tyrosine Nitration of PA700 Activates the 26S Proteasome to Induce Endothelial Dysfunction in Mice With Angiotensin II–Induced Hypertension

    PubMed Central

    Xu, Jian; Wang, Shuangxi; Wu, Yong; Song, Ping; Zou, Ming-Hui

    2010-01-01

    The ubiquitin-proteasome system has been implicated in oxidative stress–induced endothelial dysfunction in cardiovascular diseases. However, the mechanism by which oxidative stress alters the ubiquitin-proteasome system is poorly defined. The present study was conducted to determine whether oxidative modifications of PA700, a 26S proteasome regulatory subunit, contributes to angiotensin II (Ang II)–induced endothelial dysfunction. Exposure of human umbilical vein endothelial cells to low concentrations of Ang II, but not vehicle, for 6 hours significantly decreased the levels of tetrahydro-L-biopterin (BH4), an essential cofactor of endothelial NO synthase, which was accompanied by a decrease in GTP cyclohydrolase I, the rate-limiting enzyme for de novo BH4 synthesis. In addition, Ang II increased both tyrosine nitration of PA700 and the 26S proteasome activity, which were paralleled by increased coimmunoprecipitation of PA700 and the 20S proteasome. Genetic inhibition of NAD(P)H oxidase or administration of uric acid (a peroxynitrite scavenger) or NG-nitro-L-arginine methyl ester (nonselective NO synthase inhibitor) significantly attenuated Ang II–induced PA700 nitration, 26S proteasome activation, and reduction of GTP cyclohydrolase I and BH4. Finally, Ang II infusion in mice decreased the levels of both BH4 and GTP cyclohydrolase I and impaired endothelial-dependent relaxation in isolated aortas, and all of these effects were prevented by the administration of MG132, a potent inhibitor for 26S proteasome. We conclude that Ang II increases tyrosine nitration of PA700 resulting in accelerated GTP cyclohydrolase I degradation, BH4 deficiency, and consequent endothelial dysfunction in hypertension. PMID:19597039

  14. How family support affects physical activity (PA) among middle-aged and elderly people before and after they suffer from chronic diseases.

    PubMed

    Yuan, Su-Chuan; Weng, Shuo-Chun; Chou, Ming-Chih; Tang, Yih-Jing; Lee, Shu-Hsin; Chen, Der-Yuan; Chuang, Ya-Wen; Yu, Chia-Hui; Kuo, Hsien-Wen

    2011-01-01

    The more support elderly people have from their family, the less likely they are to suffer from chronic diseases. The objective of this study is to investigate how family support affects the PA middle-aged and elderly people engage in before and after they suffer from chronic diseases. We interviewed 428 middle-aged and elderly people using a structured questionnaire to measure their aerobic PA. Eighteen percent of middle-aged and elderly people did participate in PA after suffering from chronic diseases. Using multivariate logistic regression models, we found that middle-aged and elderly people who rely on family members when they are sick (OR=1.87, 95%CI=1.08-3.25) and who are accompanied by family members (OR=2.09, 95%CI=1.20-3.62) when they are healthy are more likely to exercise. The more middle-aged and elderly people are supported by their family, the more likely they are to exercise. Strengthening family relationships should help reduce the prevalence of chronic diseases among middle-aged and elderly people.

  15. Does Participation in Extracurricular Activities Impact Student Achievement?

    ERIC Educational Resources Information Center

    Abruzzo, Kristen J.; Lenis, Cristina; Romero, Yansi V.; Maser, Kevin J.; Morote, Elsa-Sofia

    2016-01-01

    This study was conducted in two high schools located in suburban, Long Island, New York, with a predominantly white population. The respondents in this study consisted of 234, 11th grade students. The data was analyzed using the structural equation model. Findings show that there is a positive correlation between percent of participation in…

  16. Elections: Secondary Teaching Activities in the Participation Series.

    ERIC Educational Resources Information Center

    Schultz, John; Taft-Morales, Hugh

    One of a series of teacher-developed curriculum guides designed to encourage student participation and involvement in important social issues, this secondary level guide helps 7th through 12th grade English and social studies educators teach about the election process. An introductory section suggests practical considerations, means of enlisting…

  17. Family Influence on Teenage Participation in School Activities.

    ERIC Educational Resources Information Center

    Cashion, Barbara G.; Dager, Edward Z.

    This paper is concerned with the relationship between social participation and family structure. A theory is developed in the framework of George Herbert Mead's analysis on the development of a consistent self in response to a generalized other. According to this theory, the influence of the family is implicated as one of the social-psychological…

  18. Use of an activity monitor and GPS device to assess community activity and participation in transtibial amputees.

    PubMed

    Hordacre, Brenton; Barr, Christopher; Crotty, Maria

    2014-03-25

    This study characterized measures of community activity and participation of transtibial amputees based on combined data from separate accelerometer and GPS devices. The relationship between community activity and participation and standard clinical measures was assessed. Forty-seven participants were recruited (78% male, mean age 60.5 years). Participants wore the accelerometer and GPS devices for seven consecutive days. Data were linked to assess community activity (community based step counts) and community participation (number of community visits). Community activity and participation were compared across amputee K-level groups. Forty-six participants completed the study. On average each participant completed 16,645 (standard deviation (SD) 13,274) community steps and 16 (SD 10.9) community visits over seven days. There were differences between K-level groups for measures of community activity (F(2,45) = 9.4, p < 0.001) and participation (F(2,45) = 6.9, p = 0.002) with lower functioning K1/2 amputees demonstrating lower levels of community activity and participation than K3 and K4 amputees. There was no significant difference between K3 and K4 for community activity (p = 0.28) or participation (p = 0.43). This study demonstrated methodology to link accelerometer and GPS data to assess community activity and participation in a group of transtibial amputees. Differences in K-levels do not appear to accurately reflect actual community activity or participation in higher functioning transtibial amputees.

  19. What Influences Participation in Leisure Activities of Children and Youth with Physical Disabilities? A Systematic Review

    ERIC Educational Resources Information Center

    Bult, M. K.; Verschuren, O.; Jongmans, M. J.; Lindeman, E.; Ketelaar, M.

    2011-01-01

    In 2001 the International Classification of Functioning (ICF) defined participation as "someone's involvement in life situations". Participation in leisure activities contributes to the development of children and their quality of life. Children with physical disabilities are known to be at risk for participation in fewer activities. The group of…

  20. Understanding Participation in Sport and Physical Activity among Children and Adults: A Review of Qualitative Studies

    ERIC Educational Resources Information Center

    Allender, Steven; Cowburn, Gill; Foster, Charlie

    2006-01-01

    Qualitative research may be able to provide an answer as to why adults and children do or do not participate in sport and physical activity. This paper systematically examines published and unpublished qualitative research studies of UK children's and adults' reasons for participation and non-participation in sport and physical activity. The…

  1. Iron oxide nanoparticles protected by NIR-active multidentate-polymers as multifunctional nanoprobes for NIRF/PA/MR trimodal imaging

    NASA Astrophysics Data System (ADS)

    Wu, Yayun; Gao, Duyang; Zhang, Pengfei; Li, Chuansheng; Wan, Qian; Chen, Chi; Gong, Ping; Gao, Guanhui; Sheng, Zonghai; Cai, Lintao

    2015-12-01

    We designed and synthesized new kinds of near-infrared catechol-based multidentate polymers which were intended to yield compact NIR-active iron oxide nanoparticles with excellent stability and biocompatibility. The resulted multifunctional nanoprobes showed great potential as multimodal contrast agents for NIRF/PA/MR trimodal imaging in vivo.We designed and synthesized new kinds of near-infrared catechol-based multidentate polymers which were intended to yield compact NIR-active iron oxide nanoparticles with excellent stability and biocompatibility. The resulted multifunctional nanoprobes showed great potential as multimodal contrast agents for NIRF/PA/MR trimodal imaging in vivo. Electronic supplementary information (ESI) available: Details of the experiment and Fig. S1-S6. See DOI: 10.1039/c5nr06660c

  2. Scientific coordination of activities for university participation in mission to planet Earth

    NASA Technical Reports Server (NTRS)

    Kalb, Michael W.

    1994-01-01

    This report describes Universities Space Research Association (USRA) activities in support of the University Participation in Mission to Planet Earth. Specifically it addresses the following areas: personnel assigned to the effort, travel, consultant participants, technical progress, and contract spending.

  3. PtrA Is Functionally Intertwined with GacS in Regulating the Biocontrol Activity of Pseudomonas chlororaphis PA23

    PubMed Central

    Shah, Nidhi; Klaponski, Natasha; Selin, Carrie; Rudney, Rachel; Fernando, W. G. Dilantha; Belmonte, Mark F.; de Kievit, Teresa R.

    2016-01-01

    In vitro inhibition of the fungal pathogen Sclerotinia sclerotiorum by Pseudomonas chlororaphis PA23 is reliant upon a LysR-type transcriptional regulator (LTTR) called PtrA. In the current study, we show that Sclerotinia stem rot and leaf infection are significantly increased in canola plants inoculated with the ptrA-mutant compared to the wild type, establishing PtrA as an essential regulator of PA23 biocontrol. LTTRs typically regulate targets that are upstream of and divergently transcribed from the LTTR locus. We identified a short chain dehydrogenase (scd) gene immediately upstream of ptrA. Characterization of a scd mutant revealed that it is phenotypically identical to the wild type. Moreover, scd transcript abundance was unchanged in the ptrA mutant. These findings indicate that PtrA regulation does not involve scd, rather this LTTR controls genes located elsewhere on the chromosome. Employing a combination of complementation and transcriptional analysis we investigated whether connections exist between PtrA and other regulators of biocontrol. Besides ptrA, gacS was the only gene able to partially rescue the wild-type phenotype, establishing a connection between PtrA and the sensor kinase GacS. Transcriptomic analysis revealed decreased expression of biosynthetic (phzA, prnA) and regulatory genes (phzI, phzR, rpoS, gacA, rsmX, rsmZ, retS) in the ptrA mutant; conversely, rsmE, and rsmY were markedly upregulated. The transcript abundance of ptrA was nine-fold higher in the mutant background indicating that this LTTR negatively autoregulates itself. In summary, PtrA is an essential regulator of genes required for PA23 biocontrol that is functionally intertwined with GacS. PMID:27713742

  4. What Turns Older Adults on to Education. Research Describing Participation in Educational Activities by Active Older Adults.

    ERIC Educational Resources Information Center

    Fisher, James C.

    A study identified distinguishing characteristics of active older adults who participate in educational activities and measured factors that motivated participation. The dependent variables were participation and nonparticipation; independent variables were educational attainment, anomie, life satisfaction, and certain learning-related factors. A…

  5. A Qualitative Study of the Achievement Goals of Recreational Exercise Participants

    ERIC Educational Resources Information Center

    Rogers, Helen; Morris, Tony; Moore, Melissa

    2008-01-01

    Physical inactivity is a major risk factor for many of today's leading causes of ill health. In-order to increase physical activity (PA) participation and information about why people engage in PA is needed. We interviewed 11 recreational exercise participants to examine their goals for participating in recreational exercise. Our results revealed…

  6. THE MEANINGFUL ACTIVITY PARTICIPATION ASSESSMENT: A MEASURE OF ENGAGEMENT IN PERSONALLY VALUED ACTIVITIES*

    PubMed Central

    EAKMAN, AARON M.; CARLSON, MIKE E.; CLARK, FLORENCE A.

    2011-01-01

    The Meaningful Activity Participation Assessment (MAPA), a recently developed 28-item tool designed to measure the meaningfulness of activity, was tested in a sample of 154 older adults. The MAPA evidenced a sufficient level of internal consistency and test-retest reliability and correlated as theoretically predicted with the Life Satisfaction Index-Z, the Satisfaction with Life Scale, the Engagement in Meaningful Activities Survey, the Purpose in Life Test, the Center for Epidemiologic Studies Depression Inventory and the Rand SF-36v2 Health Survey subscales. Zero-order correlations consistently demonstrated meaningful relationships between the MAPA and scales of psychosocial well-being and health-related quality of life. Results from multiple regression analyses further substantiated these findings, as greater meaningful activity participation was associated with better psychological well-being and health-related quality of life. The MAPA appears to be a reliable and valid measure of meaningful activity, incorporating both subjective and objective indicators of activity engagement. PMID:20649161

  7. Factors That Motivate Faculty to Participate in Professional Development Activities

    ERIC Educational Resources Information Center

    Lian, Xiaoyu

    2014-01-01

    Research has found that effective FPD activities improve faculty's instructional practices and pedagogy, technology skills, and knowledge and that the impact last over time (Rutz, Condon, Iverson, Manduca, & Willett, 2012). FPD activities also reduce job burnout and increase a sense of belonging and morale among faculty (Thomas, 2012).…

  8. Silent Students' Participation in a Large Active Learning Science Classroom

    ERIC Educational Resources Information Center

    Obenland, Carrie A.; Munson, Ashlyn H.; Hutchinson, John S.

    2012-01-01

    Active learning in large science classrooms furthers opportunities for students to engage in the content and in meaningful learning, yet students can still remain anonymously silent. This study aims to understand the impact of active learning on these silent students in a large General Chemistry course taught via Socratic questioning and…

  9. Fitness, Fun and Friends through Participation in Preferred Physical Activities: Achievable for Children with Disabilities?

    ERIC Educational Resources Information Center

    Nyquist, Astrid; Moser, Thomas; Jahnsen, Reidun

    2016-01-01

    This study investigates the preferences for actual participation in and enjoyment of physical out-of-school activities in children with physical disabilities, including what particular activities they are actually participating in, how often, with whom, where, and how enjoyable they find these activities. The data are based on structured…

  10. Activity Participation and Well-Being among Older People with Arthritis.

    ERIC Educational Resources Information Center

    Zimmer, Zachary; And Others

    1995-01-01

    Tested hypotheses that severity of arthritis is inversely associated with frequency of activity participation, and arthritis sufferers who maintain higher levels of participation, particularly in social activities, are less likely to experience a decline in well-being. Found well-being is influenced by social activity, whereas solitary and…

  11. Locations that Support Social Activity Participation of the Aging Population

    PubMed Central

    van den Berg, Pauline; Kemperman, Astrid; de Kleijn, Boy; Borgers, Aloys

    2015-01-01

    Social activities are an important aspect of health and quality of life of the aging population. They are key elements in the prevention of loneliness. In order to create living environments that stimulate older adults to engage in social activities, more insight is needed in the social activity patterns of the aging population. This study therefore analyzes the heterogeneity in older adults’ preferences for different social activity location types and the relationship between these preferences and personal and mobility characteristics. This is done using a latent class multinomial logit model based on two-day diary data collected in 2014 in Noord-Limburg in the Netherlands among 213 respondents aged 65 or over. The results show that three latent classes can be identified among the respondents who recorded social activities in the diary: a group that mainly socializes at home, a group that mainly socializes at a community center and a group that is more likely to socialize at public ‘third’ places. The respondents who did not record any interactions during the two days, are considered as a separate segment. Relationships between segment membership and personal and mobility characteristics were tested using cross-tabulations with chi-square tests and analyses of variance. The results suggest that both personal and mobility characteristics play an important role in social activity patterns of older adults. PMID:26343690

  12. Does Participation in Youth Sport Influence Sport and Physical Activity in Young Adulthood?

    ERIC Educational Resources Information Center

    Provence, Jeremy E.

    2013-01-01

    The purpose of Russell and Limle's (2013) study was to determine whether youth-sport specialization and retrospective recall of youth-sport experiences were related to participants' perceptions of and participation in sport and physical activity as young adults. A significant number of participants (76 percent) reported specializing in…

  13. Participation in Daytime Activities among People with Mild or Moderate Intellectual Disability

    ERIC Educational Resources Information Center

    Dusseljee, J. C. E.; Rijken, P. M.; Cardol, M.; Curfs, L. M. G.; Groenewegen, P. P.

    2011-01-01

    Background: Community participation has been defined as performing daytime activities by people while interacting with others. Previous studies on community participation among people with intellectual disability (ID) have mainly focused on the domestic life aspect. This study investigates the variation in community participation in the domains…

  14. Participation and Enjoyment of Leisure Activities in School-Aged Children with Cerebral Palsy

    ERIC Educational Resources Information Center

    Majnemer, Annette; Shevell, Michael; Law, Mary; Birnbaum, Rena; Chilingaryan, Gevorg; Rosenbaum, Peter; Poulin, Chantal

    2008-01-01

    The objective of this study was to characterize participation in leisure activities in children with cerebral palsy (CP) and identify determinants of greater involvement. Ninety-five children of school age (9y 7mo [SD 2y 1mo]) with CP were recruited, and participation was evaluated with the Children's Assessment of Participation and Enjoyment in a…

  15. Factors That Moderate Activity Limitation and Participation Restriction in People With Multiple Sclerosis.

    PubMed

    Goverover, Yael; Strober, Lauren; Chiaravalloti, Nancy; DeLuca, John

    2015-01-01

    We examined the variables most associated with activity limitation (i.e., cooking) and participation restriction (i.e., employment) in 72 people with multiple sclerosis (MS). Participants underwent a comprehensive neuropsychological test battery assessing memory, executive functions, visual perception, and processing speed and completed questionnaires assessing activity, participation, fatigue, and affective symptoms. Results showed that processing speed was the only variable consistently significantly related to both activity and participation. When examining specific aspects of activity and participation in isolation, employment status was significantly associated with education level, visual memory, fatigue, and processing speed. Cooking ability was associated with performance on tasks of working memory, verbal memory, and processing speed. These findings suggest that processing speed is a primary cognitive factor in MS influencing quality of both activity and participation in everyday life. PMID:26122682

  16. Active Patient Participation in the Development of an Online Intervention

    PubMed Central

    van Weel-Baumgarten, Evelyn M; Snippe, Harm Wouter; Gouw, Hans; Zijlstra, Josée M; van Dulmen, Sandra

    2014-01-01

    Background An important and challenging part of living with cancer relates to the repeated visits to the hospital. Since how patients cope between these post-diagnostic visits depends partly on the information and support received from their physician during the visits, it is important to make the most of them. Recent findings reinforce the importance of training not only the health care professionals in communication skills, but providing patients with support in communication as well. Delivering such supportive interventions online can have potential benefits in terms of accessibility, cost-effectiveness, and ability to tailor information to personal needs. However, problems with attrition (dropout, non-usage) during the test phase and poor uptake after implementation are frequently reported. The marginal level of engagement of the patient as end user seems to play a role in this. Therefore, recent research suggests integrating theory-based development methods with methods that promote involvement of the patient at an early stage. This paper describes a participatory protocol, used to let patients guide a theory-informed development process. Objective The objective of this project was to apply a bottom-up inspired procedure to develop a patient-centered intervention with corresponding evaluation and implementation plan. Methods The applied development protocol was based on the intervention mapping framework, combined with patient participatory methods that were inspired by the participation ladder and user-centred design methods. Results The applied protocol led to a self-directed online communication intervention aimed at helping patients gain control during their communications with health care professionals. It also led to an evaluation plan and an implementation plan. The protocol enabled the continuous involvement of patient research partners and the partial involvement of patient service users, which led to valuable insights and improvements. Conclusions

  17. Determinants of participation in leisure activities among adolescents with cerebral palsy.

    PubMed

    Shikako-Thomas, Keiko; Shevell, Michael; Schmitz, Norbert; Lach, Lucyna; Law, Mary; Poulin, Chantal; Majnemer, Annette

    2013-09-01

    Studies have identified restrictions in engagement in leisure activities for adolescents with disabilities. Participation is a complex construct and likely influenced by a variety of factors. These potential determinants have not yet been sufficiently explored in the population of adolescents with cerebral palsy (CP). The objective of this study is to estimate the potential influence of adolescent characteristics and environmental factors as determinants of participation in leisure activities for adolescents with CP. A cross-sectional design was used. Participants were adolescents (12-19 years old) with cerebral palsy. Participants were assessed with the Vineland Adaptive Behavior Scale - II, Gross Motor Function Measure, Gross Motor Function Classification System, Manual Ability Classification System and completed the Self-Perception Profile for Adolescents, Dimensions of Mastery Questionnaire, Strengths and Difficulties Questionnaire, Family Environment Scale, the European Child Environment Questionnaire and the Preferences for Activities of Children. The main outcome measure was the Children's Assessment of Participation and Enjoyment. 187 adolescents (age M=15.4; SD=2.2) completed the study. Multivariate models of participation in leisure revealed associations with factors related to the adolescents' functional characteristics and attitudes, the family environment, socioeconomic status, and contextual factors such as school type, and collectively explained from 28% (diversity of skill-based activities) up to 48% (intensity and diversity of self-improvement activities) of the variance in intensity and diversity in five leisure participation domains (diversity: r(2)=.33 recreational; r(2)=.39 active-physical; r(2)=.33 social activities). Adolescent's mastery motivation, self-perception and behavior were individually associated with participation in different activity domains, but did not strongly predict participation within multivariate models, while preferences

  18. The tissue plasminogen activator (tPA)/plasmin extracellular proteolytic system regulates seizure-induced hippocampal mossy fiber outgrowth through a proteoglycan substrate.

    PubMed

    Wu, Y P; Siao, C J; Lu, W; Sung, T C; Frohman, M A; Milev, P; Bugge, T H; Degen, J L; Levine, J M; Margolis, R U; Tsirka, S E

    2000-03-20

    Short seizure episodes are associated with remodeling of neuronal connections. One region where such reorganization occurs is the hippocampus, and in particular, the mossy fiber pathway. Using genetic and pharmacological approaches, we show here a critical role in vivo for tissue plasminogen activator (tPA), an extracellular protease that converts plasminogen to plasmin, to induce mossy fiber sprouting. We identify DSD-1-PG/phosphacan, an extracellular matrix component associated with neurite reorganization, as a physiological target of plasmin. Mice lacking tPA displayed decreased mossy fiber outgrowth and an aberrant band at the border of the supragranular region of the dentate gyrus that coincides with the deposition of unprocessed DSD-1-PG/phosphacan and excessive Timm-positive, mossy fiber termini. Plasminogen-deficient mice also exhibit the laminar band and DSD- 1-PG/phosphacan deposition, but mossy fiber outgrowth through the supragranular region is normal. These results demonstrate that tPA functions acutely, both through and independently of plasmin, to mediate mossy fiber reorganization.

  19. Total Participation Techniques: Making Every Student an Active Learner

    ERIC Educational Resources Information Center

    Himmele, Persida; Himmele, William

    2011-01-01

    Yes, there are easy-to-use and incredibly effective alternatives to the "stand and deliver" approach to teaching that causes so many students to tune out--or even drop out. Here's your opportunity to explore dozens of ways to engage K-12 students in active learning and allow them to demonstrate the depth of their knowledge and understanding. The…

  20. Shaping Student Activists: Discursive Sensemaking of Activism and Participation Research

    ERIC Educational Resources Information Center

    Taha, Diane E.; Hastings, Sally O.; Minei, Elizabeth M.

    2015-01-01

    As social media becomes a more potent force in society, particularly for younger generations, the role in activism has been contested. This qualitative study examines 35 interviews with students regarding their perceptions of the use of social media in social change, their perceptions of activists, and their level of self-identification as an…

  1. Prospective Relations between Organized Activity Participation and Psychopathology during Adolescence

    ERIC Educational Resources Information Center

    Bohnert, Amy M.; Garber, Judy

    2007-01-01

    This longitudinal study examined psychopathology as a predictor and outcome of organized activity involvement during high school among 198 adolescents who varied in risk for psychopathology as a function of their mother's depression history. Higher levels of internalizing and externalizing symptoms in eighth grade significantly predicted lower…

  2. Lytic efficacy of apoli protein E2 (ApoE2) and recombinant tissue plasminogen activator (rt-PA) treatment with 120 kHz ultrasound in an in-vitro human clot model

    NASA Astrophysics Data System (ADS)

    Meunier, Jason M.; Cheng, Jason Y.; Clark, Joseph F.; Shaw, George J.

    2005-04-01

    Currently, the only FDA approved therapy for acute ischemic stroke is recombinant tissue plasminogen activator (rt-PA). However rt-PA has substantial side effects such as hemorrhage. This has led to interest in other potential therapies. For example, ultrasound (US) increases the lytic efficacy of rt-PA. Also, apolipoprotein E2 (ApoE2) increases rt-PA activity. This suggests combining US, ApoE2 and rt-PA to improve thrombolysis, but the efficacy is not known. Here, the lytic efficacy of apoE2, rt-PA and 120 kHz US is measured in a human clot model. Whole blood was obtained from volunteers, after local institutional approval. Clots were formed in 1.7 mm micropipettes, and placed in a water tank that allowed microscopic video imaging during US and thrombolytic exposure. Clots were treated with rt-PA ([rt-PA]=3.15 μg/ml), rt-PA and apoE2 ([apoE2]=9.8 μg/ml), or rt-PA, apoE2 and 120 kHz US (0.35 MPa, PRF=1667 Hz, 80% duty cycle) for 15 min at 37°C in human plasma. Clot lysis was visually recorded and the lysis depth (LD) determined from these data using an image analysis algorithm. LD was linear with time for all treatments (R2>=0.81), allowing the determination of a lytic rate (LR). LR was found to be 0.35+/-0.03, 1.55+/-0.11, and 0.75+/-0.04 μm/min for the rt-PA, rt-PA and apoE2, and US treated groups respectively. The thrombolytic efficacy of rt-PA is enhanced by ApoE2. The interaction of 120 kHz with apoE2 and rt-PA showed a reduced lytic efficacy compared with rt-PA and apoE2 treatment alone. It is possible that US interferes with the ApoE2-mediated activation of rt-PA.

  3. Upper Elementary Boys' Participation during Group Singing Activities in Single-Sex and Coeducational Classes

    ERIC Educational Resources Information Center

    Bazzy, Zadda M.

    2010-01-01

    As boys in the upper elementary grades become increasingly influenced by peer pressure, many are less likely to participate in singing activities because singing is considered a "feminine" activity. The purpose of this research was to explore if there was an effect on upper elementary boys' level of participation during group singing activities…

  4. Factors Related to Rural Young Adolescents' Participation in Outdoor, Noncompetitive Physical Activity

    ERIC Educational Resources Information Center

    Christiana, Richard W.; Davis, Marsha; Wilson, Mark G.; McCarty, Frances A.; Green, Gary T.

    2014-01-01

    Purpose: Young adolescents who have little interest in participating in competitive team sports are at an increased risk for physical inactivity. Noncompetitive outdoor physical activity can provide young adolescents with increased opportunities to participate in physical activities that appeal to them and have positive health effects. The purpose…

  5. Title IX, Girls' Sports Participation, and Adult Female Physical Activity and Weight

    ERIC Educational Resources Information Center

    Kaestner, Robert; Xu, Xin

    2010-01-01

    Arguably, the most important school-based intervention to increase physical activity was Title IX of the Education Amendments of 1972, which led to a 600% increase in girls' sports participation between 1972 and 1978. We studied the effect of this increase in sports participation and athletic opportunities while young on the physical activity and…

  6. Participation in Extracurricular Activities and Adolescent Adjustment: Cross-Sectional and Longitudinal Findings

    ERIC Educational Resources Information Center

    Darling, Nancy

    2005-01-01

    This study extends previous understanding of the association between adolescent extracurricular activity participation and adjustment by asking whether participation in school-based extracurricular activities is associated with lower substance use and depression, higher grades and academic aspirations, and more positive attitude toward school. In…

  7. Action Research to Encourage Pupils' Active Participation in the Sustainable School

    ERIC Educational Resources Information Center

    Katsenou, Christina; Flogaitis, Evgenia; Liarakou, Georgia

    2015-01-01

    This article aims to explore the contribution of action research to the development of active participation of pupils in the context of the sustainable school. Action research is looked at not simply as a methodological tool for the exploration of participation, but as a key element of the educational actions that promote the active participation…

  8. Focused Campaign Increases Activity among Participants in "Nature's Notebook," a Citizen Science Project

    ERIC Educational Resources Information Center

    Crimmins, Theresa M.; Weltzin, Jake F.; Rosemartin, Alyssa H.; Surina, Echo M.; Marsh, Lee; Denny, Ellen G.

    2014-01-01

    Science projects, which engage non-professional scientists in one or more stages of scientific research, have been gaining popularity; yet maintaining participants' activity level over time remains a challenge. The objective of this study was to evaluate the potential for a short-term, focused campaign to increase participant activity in a…

  9. Parents' Networking Strategies: Participation of Formal and Informal Parent Groups in School Activities and Decisions

    ERIC Educational Resources Information Center

    Wanat, Carolyn L.

    2010-01-01

    This case study examined parent groups' involvement in school activities and their participation in decision making. Research questions included the following: (1) What is the nature of parent groups in schools? (2) What activities and issues gain parent groups' attention and participation? (3) How do parent groups communicate concerns about…

  10. Australian Adolescents' Extracurricular Activity Participation and Positive Development: Is the Relationship Mediated by Peer Attributes?

    ERIC Educational Resources Information Center

    Blomfield, Corey; Barber, Bonnie

    2010-01-01

    Adolescent participation in extracurricular activities is associated with numerous positive outcomes, yet the mechanisms underlying this relationship are largely unknown. This study had two goals: to investigate the association between participation in extracurricular activities and indicators of positive and negative development for Australian…

  11. Association between School Policies and Built Environment, and Youth's Participation in Various Types of Physical Activities

    ERIC Educational Resources Information Center

    Ward, Stephanie; Bélanger, Mathieu; Donovan, Denise; Caissie, Isabelle; Goguen, Julie; Vanasse, Allain

    2015-01-01

    Background: School environmental characteristics may be associated with youth's participation in different types of physical activities (PAs). This study aimed to identify which school policies and built environmental characteristics were associated with participation in organized, nonorganized, individual, and group-based activities. Methods:…

  12. Secretion of multi-protein migratory complex induced by Toxoplasma gondii infection in macrophages involves the uPA/uPAR activation system.

    PubMed

    Schuindt, Sara Hellen Santos; Oliveira, Bruno Cabral de Lima; Pimentel, Pollyana Maria de Oliveira; Resende, Thatiane Lacerda; Retamal, Cláudio A; DaMatta, Renato A; Seipel, Daniele; Arnholdt, Andrea Cristina Vetö

    2012-05-25

    Toxoplasmosis is a world wide spread zoonosis caused by Toxoplasma gondii, an obligate intracellular parasite that is able to disseminate into deep tissues and cross biological barriers, reaching immunoprivileged sites such as the brain and retina. The parasite is able to infect macrophages and dendritic cells for dispersal throughout the body. However, the molecular mechanisms or outcomes of the subversion of the host cell are largely unknown. Recently our group established that metalloproteinases are involved in migration of infected macrophages. Herein, we evaluated the recruitment of host invasive machinery components in T. gondii infected murine macrophages. We showed by immunoprecipitation assays that MMP-9, CD44 TIMP-1 and uPAR were secreted as a multi-protein complex by infected macrophages. Zymographic analysis revealed that MMP-9 was present in its pro- and active form. Moreover, inhibition of uPA/uPAR pathway by PAI-1 decreased secretion of MMP-9 active forms, as well those associated to uPAR and TIMP-1, but not to CD44. Data presented here suggest that MMP-9 is secreted as a multiprotein complex by T. gondii infected macrophages, similar to that observed in metastatic cells. We further speculate that uPA/uPAR system is involved in the expression/secretion of complexes containing active MMP-9 forms.

  13. Antibacterial activity of defensin PaDef from avocado fruit (Persea americana var. drymifolia) expressed in endothelial cells against Escherichia coli and Staphylococcus aureus.

    PubMed

    Guzmán-Rodríguez, Jaquelina Julia; López-Gómez, Rodolfo; Suárez-Rodríguez, Luis M; Salgado-Garciglia, Rafael; Rodríguez-Zapata, Luis C; Ochoa-Zarzosa, Alejandra; López-Meza, Joel E

    2013-01-01

    Antimicrobial therapy is a useful tool to control infectious diseases in general and rising antibiotic resistant microorganisms in particular. Alternative strategies are desirable, and antimicrobial peptides (AMP) represent attractive control agents. Mexican avocado (Persea americana var. drymifolia) is used in traditional medicine; however, the AMP production has not been reported in this plant. We obtained a cDNA library from avocado fruit and clone PaDef was identified, which has a cDNA (249 bp) encoding a protein (78 aa) homologous with plant defensins (>80%). We expressed the defensin PaDef cDNA (pBME3) in the bovine endothelial cell line BVE-E6E7. Polyclonal and clonal populations were obtained and their activity was evaluated against Escherichia coli, Staphylococcus aureus, and Candida albicans. E. coli viability was inhibited with 100 μg/mL of total protein from clones (>55%). Also, S. aureus viability was inhibited from 50 μg/mL total protein (27-38%) but was more evident at 100 μg/mL (52-65%). This inhibition was higher than the effect showed by polyclonal population (~23%). Finally, we did not detect activity against C. albicans. These results are the first report that shows antimicrobial activity of a defensin produced by avocado and suggest that this AMP could be used in the control of pathogens. PMID:24319695

  14. Antibacterial Activity of Defensin PaDef from Avocado Fruit (Persea americana var. drymifolia) Expressed in Endothelial Cells against Escherichia coli and Staphylococcus aureus

    PubMed Central

    Guzmán-Rodríguez, Jaquelina Julia; López-Gómez, Rodolfo; Suárez-Rodríguez, Luis M.; Salgado-Garciglia, Rafael; Rodríguez-Zapata, Luis C.; Ochoa-Zarzosa, Alejandra; López-Meza, Joel E.

    2013-01-01

    Antimicrobial therapy is a useful tool to control infectious diseases in general and rising antibiotic resistant microorganisms in particular. Alternative strategies are desirable, and antimicrobial peptides (AMP) represent attractive control agents. Mexican avocado (Persea americana var. drymifolia) is used in traditional medicine; however, the AMP production has not been reported in this plant. We obtained a cDNA library from avocado fruit and clone PaDef was identified, which has a cDNA (249 bp) encoding a protein (78 aa) homologous with plant defensins (>80%). We expressed the defensin PaDef cDNA (pBME3) in the bovine endothelial cell line BVE-E6E7. Polyclonal and clonal populations were obtained and their activity was evaluated against Escherichia coli, Staphylococcus aureus, and Candida albicans. E. coli viability was inhibited with 100 μg/mL of total protein from clones (>55%). Also, S. aureus viability was inhibited from 50 μg/mL total protein (27–38%) but was more evident at 100 μg/mL (52–65%). This inhibition was higher than the effect showed by polyclonal population (~23%). Finally, we did not detect activity against C. albicans. These results are the first report that shows antimicrobial activity of a defensin produced by avocado and suggest that this AMP could be used in the control of pathogens. PMID:24319695

  15. Antibacterial activity of defensin PaDef from avocado fruit (Persea americana var. drymifolia) expressed in endothelial cells against Escherichia coli and Staphylococcus aureus.

    PubMed

    Guzmán-Rodríguez, Jaquelina Julia; López-Gómez, Rodolfo; Suárez-Rodríguez, Luis M; Salgado-Garciglia, Rafael; Rodríguez-Zapata, Luis C; Ochoa-Zarzosa, Alejandra; López-Meza, Joel E

    2013-01-01

    Antimicrobial therapy is a useful tool to control infectious diseases in general and rising antibiotic resistant microorganisms in particular. Alternative strategies are desirable, and antimicrobial peptides (AMP) represent attractive control agents. Mexican avocado (Persea americana var. drymifolia) is used in traditional medicine; however, the AMP production has not been reported in this plant. We obtained a cDNA library from avocado fruit and clone PaDef was identified, which has a cDNA (249 bp) encoding a protein (78 aa) homologous with plant defensins (>80%). We expressed the defensin PaDef cDNA (pBME3) in the bovine endothelial cell line BVE-E6E7. Polyclonal and clonal populations were obtained and their activity was evaluated against Escherichia coli, Staphylococcus aureus, and Candida albicans. E. coli viability was inhibited with 100 μg/mL of total protein from clones (>55%). Also, S. aureus viability was inhibited from 50 μg/mL total protein (27-38%) but was more evident at 100 μg/mL (52-65%). This inhibition was higher than the effect showed by polyclonal population (~23%). Finally, we did not detect activity against C. albicans. These results are the first report that shows antimicrobial activity of a defensin produced by avocado and suggest that this AMP could be used in the control of pathogens.

  16. Role of tyrosine 131 in the active site of paAzoR1, an azoreductase with specificity for the inflammatory bowel disease prodrug balsalazide

    PubMed Central

    Wang, Chan-Ju; Laurieri, Nicola; Abuhammad, Areej; Lowe, Edward; Westwood, Isaac; Ryan, Ali; Sim, Edith

    2010-01-01

    Azoreductase 1 from Pseudomonas aeruginosa strain PAO1 (paAzoR1) catalyses the activation of the prodrug balsalazide and reduces the azo dye methyl red using reduced nicotinamide adenine dinucleotide cofactor as an electron donor. To investigate the mechanism of the enzyme, a Y131F mutation was introduced and the enzymic properties of the mutant were compared with those of the wild-type enzyme. The crystallographic structure of the mutant with methyl red bound was solved at 2.1 Å resolution and compared with the wild-type structure. Tyr131 is important in the architecture of the active site but is not essential for enzymic activity. PMID:20057057

  17. Is Self-Reported Physical Activity Participation Associated with Lower Health Services Utilization among Older Adults? Cross-Sectional Evidence from the Canadian Community Health Survey.

    PubMed

    Fisher, Koren L; Harrison, Elizabeth L; Reeder, Bruce A; Sari, Nazmi; Chad, Karen E

    2015-01-01

    Purpose. To examine relationships between leisure time physical activity (LTPA) and health services utilization (H) in a nationally representative sample of community-dwelling older adults. Methods. Cross-sectional data from 56,652 Canadian Community Health Survey respondents aged ≥ 50 years (48% M; 52% F; mean age 63.5 ± 10.2 years) were stratified into three age groups and analysed using multivariate generalized linear modeling techniques. Participants were classified according to PA level based on self-reported daily energy expenditure. Nonleisure PA (NLPA) was categorized into four levels ranging from mostly sitting to mostly lifting objects. Results. Active 50-65-year-old individuals were 27% less likely to report any GP consultations (ORadj = 0.73;  P < 0.001) and had 8% fewer GP consultations annually (IRRadj = 0.92;  P < 0.01) than their inactive peers. Active persons aged 65-79 years were 18% less likely than inactive respondents to have been hospitalized overnight in the previous year (ORadj = 0.82,  P < 0.05). Higher levels of NLPA were significantly associated with lower levels of HSU, across all age groups. Conclusion. Nonleisure PA appeared to be a stronger predictor of all types of HSU, particularly in the two oldest age groups. Considering strategies that focus on reducing time spent in sedentary activities may have a positive impact on reducing the demand for health services. PMID:26347491

  18. Is Self-Reported Physical Activity Participation Associated with Lower Health Services Utilization among Older Adults? Cross-Sectional Evidence from the Canadian Community Health Survey

    PubMed Central

    Fisher, Koren L.; Harrison, Elizabeth L.; Reeder, Bruce A.; Sari, Nazmi; Chad, Karen E.

    2015-01-01

    Purpose. To examine relationships between leisure time physical activity (LTPA) and health services utilization (H) in a nationally representative sample of community-dwelling older adults. Methods. Cross-sectional data from 56,652 Canadian Community Health Survey respondents aged ≥ 50 years (48% M; 52% F; mean age 63.5 ± 10.2 years) were stratified into three age groups and analysed using multivariate generalized linear modeling techniques. Participants were classified according to PA level based on self-reported daily energy expenditure. Nonleisure PA (NLPA) was categorized into four levels ranging from mostly sitting to mostly lifting objects. Results. Active 50–65-year-old individuals were 27% less likely to report any GP consultations (ORadj = 0.73;  P < 0.001) and had 8% fewer GP consultations annually (IRRadj = 0.92;  P < 0.01) than their inactive peers. Active persons aged 65–79 years were 18% less likely than inactive respondents to have been hospitalized overnight in the previous year (ORadj = 0.82,  P < 0.05). Higher levels of NLPA were significantly associated with lower levels of HSU, across all age groups. Conclusion. Nonleisure PA appeared to be a stronger predictor of all types of HSU, particularly in the two oldest age groups. Considering strategies that focus on reducing time spent in sedentary activities may have a positive impact on reducing the demand for health services. PMID:26347491

  19. The Relationship between Activities of Daily Living and Life Satisfaction in the Elderly: Active Engagement as Compared to Passive Participation.

    ERIC Educational Resources Information Center

    Iannuzzelli, Jena; England, Eileen M.

    Daily activities and social contact were studied as influences on the life satisfaction of elderly people. It was considered that all activities might not be equal and that individuals who participate in more active activities and who have more active social contacts would score higher in life satisfaction than those who engage in inactive…

  20. Participants' experiences of facilitated physical activity for the management of depression in primary care.

    PubMed

    Searle, Aidan; Haase, Anne M; Chalder, Melanie; Fox, Kenneth R; Taylor, Adrian H; Lewis, Glyn; Turner, Katrina M

    2014-11-01

    A qualitative study was conducted within a randomised trial of facilitated physical activity for depression based on Self-Determination Theory and motivational interviewing. Interviews were held with 19 participants at 4 months, and 12 participants were re-interviewed 8 months later. The interviews were analysed in accordance with Grounded Theory using framework. Themes consisted of the following: relationship with the physical activity facilitators, mode of facilitation, impact of contact with physical activity facilitator/assimilation and future plans, change in activity, and effectiveness of physical activity facilitator techniques. Engagement in physical activity was enhanced within an autonomy-supportive environment.

  1. Independent and joint effects of personality on intentions to become an active participant in local union activities in Canada.

    PubMed

    McPhee, Deborah M; Sears, Greg J; Wiesner, Willi H

    2014-01-01

    Drawing on the theory of planned behavior (TPB), this field study (N = 282) investigates the impact of two focal personality traits, extraversion and conscientiousness, on employees' attitudes and intentions to actively participate in their local union. Consistent with the TPB, subjective norms, perceived behavioral control, and attitudes toward participation each explained unique variance in union participation intentions. Furthermore, results revealed that extraversion was positively related, and conscientiousness was negatively related to participation intentions, with attitudes toward participation mediating these effects. A significant interaction between extraversion and conscientiousness was also observed, such that introverted workers higher in conscientiousness were less inclined to express positive attitudes toward union participation. Overall, these results provide support for the utility of the TPB in predicting union participation intentions and highlight the vital role that personality traits may play in determining union participation attitudes and intentions. PMID:24684076

  2. Perceptions of Physical Activity and Influences of Participation in Young African-American Adolescent Girls.

    PubMed

    Morrison, Shannon; Knight, Candace; Crew-Gooden, Annette

    2015-12-01

    The purpose of this study was to explore African-American adolescent girls' perceptions of physical activity participation, examine how physical activity is defined and identify the most preferred forms of physical activity. Qualitative focus group interviews of a convenience sample (N = 30; Mean age = 14.3 years) were used to identifyfactors that influence African-American girls' physical activity participation as well as to explore how physical activity is defined within this population. Four themes emerged: (a) benefits and motivation to engage in physical activity, (b) behaviors consistent with perceived physical activity, (c) most enjoyable physical activity/activities, and (d) barriers to physical activity. Physical activities that promoted normative adolescent development (i.e., autonomy) were perceived as most beneficial, desirable, and most likely to be sustained. Implications of these findings highlight the importance of the incorporation of socialization and peer engagement in physical activity programs designed for African-American adolescent girls. PMID:27045157

  3. Barriers to Participation in Physical Activity Among South Sudanese Children in South Australia: Parents' Perspectives.

    PubMed

    Mude, William; Mwanri, Lillian

    2016-01-01

    Physical inactivity is one of the determinants of childhood obesity. Although its facilitators are well documented for the general community, limited evidence exists informing newly arrived and emerging migrant communities in Australia. To explore parents' perspectives of barriers to participation in physical activity among South Sudanese children in South Australia. Qualitative, face-to-face interviews were conducted with parents. Data were transcribed, coded, and analyzed thematically using NVivo software. Multiple and complex barriers to physical activity participation were described. Enabling and supportive programs are needed to improve physical activity participation and health outcomes of new migrants. PMID:27536934

  4. Anti-tissue plasminogen activator (tPA) as an effective therapy of neonatal hypoxia-ischemia with and without inflammation.

    PubMed

    Yang, Dianer; Kuan, Chia-Yi

    2015-04-01

    Hypoxic-ischemic brain injury is an important cause of neurodevelopmental deficits in neonates. Intrauterine infection and the ensuing fetal inflammatory responses augment hypoxic-ischemic brain injury and attenuate the efficacy of therapeutic hypothermia. Here, we review evidences from preclinical studies suggesting that the induction of brain parenchymal tissue-type plasminogen activator (tPA) plays an important pathogenic role in these conditions. Moreover, administration of a stable-mutant form of plasminogen activator inhibitor-1 called CPAI confers potent protection against hypoxic-ischemic injury with and without inflammation via different mechanisms. Besides intracerebroventricular injection, CPAI can also be administered into the brain using a noninvasive intranasal delivery strategy, adding to its applicability in clinical use. In sum, the therapeutic potential of CPAI in neonatal care merits further investigation with large-animal models of hypoxia-ischemia and cerebral palsy. PMID:25475942

  5. Purpose and pleasure in late life: Conceptualising older women's participation in art and craft activities.

    PubMed

    Liddle, Jeannine L M; Parkinson, Lynne; Sibbritt, David W

    2013-12-01

    The fourth age, as the last stage of life, represents a final challenge to find personal meaning in the face of changing capacities, illness and disability. Participation in valued activities is important for sustaining interest in life and has been associated with enhanced health and well-being. Art and craft activities are a popular form of participation amongst women in late life with growing international interest in the potential for these types of activities to maintain health and well-being and address problems of social isolation. Drawing on open text comments from 114 women enrolled in the Australian Longitudinal Study on Women's Health and in-depth interviews with 23 women all aged in their eighties, this paper explores the nature of older women's participation in art and craft activities and conceptualises links between participation in these activities and health and well-being in late life. Participation in art and craft activities is complex and dynamic, comprising cognitive and physical processes infused with emotion and occurs in the context of social relationships, physical spaces, physical ailments and beliefs about the value of the activities. By participating in art and craft activities, older women find purpose in their lives, contributing to their subjective well-being whilst helping and being appreciated by others. They develop a self view as enabled and as such take on new art and craft challenges, continue to learn and develop as art and craft makers and remain open to new possibilities.

  6. A Review of Research on Small-School Student Participation in Extracurricular Activities.

    ERIC Educational Resources Information Center

    Stevens, Neil G.; Peltier, Gary L.

    1994-01-01

    Research reveals that high school students in small schools participate more in extracurricular activities than their peers in large schools; that a high degree of student participation provides opportunities for enhancing leadership, responsibility, and motivation; that students in small schools feel needed; and that the benefits of…

  7. Exploring Social and Environmental Factors Affecting Adolescents' Participation in Physical Activity

    ERIC Educational Resources Information Center

    Dagkas, Symeon; Stathi, Afroditi

    2007-01-01

    This study explores the social factors that influence young people's participation in school and out of school physical activities. Fifty-two 16-year-old adolescents from different socioeconomic backgrounds in one suburban and one inner-city secondary school in the Midlands, UK, participated in group interviews which explored their perceptions…

  8. Changes in Social Participation and Volunteer Activity among Recently Widowed Older Adults

    ERIC Educational Resources Information Center

    Donnelly, Elizabeth A.; Hinterlong, James E.

    2010-01-01

    Purpose: Widowhood eliminates a key source of support that may trigger greater involvement in social activities and volunteer participation, which are related to better late-life health and functioning. We reexamine and build upon 2 recent studies exploring recent widowhood and social participation. Using different data, we perform a…

  9. Attitudes toward the Participation of Individuals with Disabilities in Physical Activity: A Review

    ERIC Educational Resources Information Center

    Hutzler, Yeshayahu

    2003-01-01

    This review covers articles published during the recent two decades on attitudes toward the participation of individuals with disabilities in physical activity. Research literature has been retrieved and analyzed by content and quality, across research type categories (cross sectional vs. intervention) and members of the participation context…

  10. Participation in Home, Extracurricular, and Community Activities among Children and Young People with Cerebral Palsy

    ERIC Educational Resources Information Center

    Orlin, Margo N.; Palisano, Robert J.; Chiarello, Lisa A.; Kang, Lin-Ju; Polansky, Marcia; Almasri, Nihad; Maggs, Jill

    2010-01-01

    Aim: Participation in home, extracurricular, and community activities is a desired outcome of rehabilitation services for children and young people with cerebral palsy (CP). The purpose of this study was to investigate the effect of age and gross motor function on participation among children and young people with CP. Method: Five hundred…

  11. The Impact of Participating in a Peer Assessment Activity on Subsequent Academic Performance

    ERIC Educational Resources Information Center

    Jhangiani, Rajiv S.

    2016-01-01

    The present study investigates the impact of participation in a peer assessment activity on subsequent academic performance. Students in two sections of an introductory psychology course completed a practice quiz 1 week prior to each of three course exams. Students in the experimental group participated in a five-step double-blind peer assessment…

  12. "Class-Bucks": A Motivational Tool to Encourage Active Student Participation during Lectures

    ERIC Educational Resources Information Center

    de Jager, T.

    2013-01-01

    The purpose of this study was to ascertain the influence of an extrinsic motivational tool, "class-bucks," on the possibility of improving first year student-teachers' participation in active learning at Tshwane University of Technology in South Africa. Research participants (n=289) were divided into four classes and engaged in this…

  13. Adolescents with Learning Disabilities: Are They Allowed to Participate in Activities?

    ERIC Educational Resources Information Center

    Plata, Maximino; Trusty, Jerry; Glasgow, Danny

    2005-01-01

    Fifty-one Anglo American (28 educationally successful, 23 educationally at risk) and 20 African American (10 educationally successful, 10 educationally at risk) high school boys participated in a study to determine their willingness to allow same-sex peers with learning disabilities (LD) participate in a variety of activities. Kruskal-Wallis…

  14. The Comparative Impacts of Social Justice Educational Methods on Political Participation, Civic Engagement, and Multicultural Activism

    ERIC Educational Resources Information Center

    Krings, Amy; Austic, Elizabeth A.; Gutiérrez, Lorraine M.; Dirksen, Kaleigh E.

    2015-01-01

    This cross-sectional, repeated measures, quasi-experimental study evaluates changes in college students' commitment toward, and confidence in, political participation, civic engagement, and multicultural activism. Our sample (n = 653) consisted of college students in a Midwestern university who participated in one of three social justice education…

  15. Determinants of Intensity of Participation in Leisure and Recreational Activities by Children with Cerebral Palsy

    ERIC Educational Resources Information Center

    Palisano, Robert J.; Chiarello, Lisa A.; Orlin, Margo; Oeffinger, Donna; Polansky, Marcy; Maggs, Jill; Bagley, Anita; Gorton, George

    2011-01-01

    Aim: To test a model of child, family, and service determinants of intensity of participation in leisure and recreational activities by children with cerebral palsy (CP). Method: Participants were 288 children with CP, age range 6 to 12 years (mean 9y 8mo, SD 2y), and their parents from seven children's hospitals. The sample comprised 166 (57.6%)…

  16. Self-Regulated Learning and Perceived Health among Students Participating in University Physical Activity Classes

    ERIC Educational Resources Information Center

    McBride, Ron E.; Xiang, Ping

    2013-01-01

    Three hundred and sixty-one students participating in university physical activity classes completed questionnaires assessing perceived health and self-regulated learning. In addition, 20 students (11 men; 9 women) were interviewed about their reasons for enrolling, participation and goals in the class. Results indicated the students endorsed…

  17. Participation in Student Activities as a Variable in the Educational Attainment and Expectation Process.

    ERIC Educational Resources Information Center

    Rehberg, Richard A.; Schafer, Walter E.

    Four-wave, five-year longitudinal panel data are used to assess selected antecedents and consequences of participation in student activities. Path analysis reveals that the "early" or freshman year educational expectations of high school students are a critical determinant of participation. Measured intelligence is also a determinant of senior…

  18. Motivational Attitudes toward Participating in Physical Activity among International Students Attending Colleges in the United States

    ERIC Educational Resources Information Center

    Yoh, Taeho

    2009-01-01

    The purpose of this study was to investigate motivational attitudes toward participating in physical activity among international students attending colleges in the United States. Five-hundred twenty-one students participated in this study. The results indicated that the factors of organic development ("keeping good health and physical condition,…

  19. Participating in Political Activities: Political Systems, Unit Three. Comparing Political Experiences, Experimental Edition.

    ERIC Educational Resources Information Center

    Gillespie, Judith A.; Patrick, John J.

    The third unit to the first-semester course, "Comparing Political Experiences," provides 16 activities to help 12th-grade students acquire in-depth knowledge of various kinds of political activities, such as decision making, leadership, communication, and participation. The activities and readings are divided into six sections which stress the…

  20. Location, Timing, and Social Structure Patterns Related to Physical Activity Participation in Weight Loss Programs

    ERIC Educational Resources Information Center

    Gay, Jennifer L.; Trevarthen, Grace

    2013-01-01

    Less than half of the adults in the United States meet national guidelines for physical activity. Physical activity programs can induce short-term improvements in physical activity. To develop effective interventions, researchers and practitioners should consider the timing, location, and social structure patterns of participants. Using a pretest,…

  1. Comparing Participants' Rating and Compendium Coding to Estimate Physical Activity Intensities

    ERIC Educational Resources Information Center

    Masse, Louise C.; Eason, Karen E.; Tortolero, Susan R.; Kelder, Steven H.

    2005-01-01

    This study assessed agreement between participants' rating (PMET) and compendium coding (CMET) of estimating physical activity intensity in a population of older minority women. As part of the Women on the Move study, 224 women completed a 7-day activity diary and wore an accelerometer for 7 days. All activities recorded were coded using PMET and…

  2. Fifth Grade Students' Experiences Participating in Active Gaming in Physical Education: The Persistence to Game

    ERIC Educational Resources Information Center

    Hansen, Lisa; Sanders, Steve

    2010-01-01

    Although video games are often associated with sedentary behaviors, active gaming is a new genre that requires children to become physically active while playing the games. In this study six fifth grade students' experiences participating in active gaming in eight-week physical education classes were explored. Qualitative methods of interviews,…

  3. High School Students' Participation in Music Activities beyond the School Day

    ERIC Educational Resources Information Center

    Kuntz, Tammy L.

    2011-01-01

    The purpose of this qualitative study was to investigate the music activities that high school band students are involved in and how these activities might lead to lifelong music participation. Specific research questions were the following: (a) In what activities are high school band students involved? (b) What are high school band directors…

  4. Residents' perceptions and experiences of social interaction and participation in leisure activities in residential aged care.

    PubMed

    Thomas, Jessica E; O'Connell, Beverly; Gaskin, Cadeyrn J

    2013-10-01

    Social interaction and participation in leisure activities are positively related to the health and well-being of elderly people. The main focus of this exploratory study was to investigate elderly peoples' perceptions and experiences of social interaction and leisure activities living in a residential aged care (RAC) facility. Six residents were interviewed. Themes emerging from discussions about their social interactions included: importance of family, fostering friendships with fellow residents, placement at dining room tables, multiple communication methods, and minimal social isolation and boredom. Excursions away from the RAC facility were favourite activities. Participants commonly were involved in leisure activities to be socially connected. Poor health, family, the RAC facility, staffing, transportation, and geography influenced their social interaction and participation in leisure activities. The use of new technologies and creative problem solving with staff are ways in which residents could enhance their social lives and remain engaged in leisure activities. PMID:24299253

  5. Sensory Patterns, Obesity, and Physical Activity Participation of Children With Autism Spectrum Disorder.

    PubMed

    Lawson, Lisa Mische; Foster, Lauren

    2016-01-01

    Obesity is a public health concern for the population in general and for children with autism spectrum disorder (ASD) specifically. The purpose of this study was to understand relationships between sensory patterns, obesity, and physical activity engagement of children with ASD (N = 77) sampled from a specialized community-based swimming program. This retrospective correlational study analyzed program data. Results show that almost half (42.2%) of the children were overweight or obese, and sensory avoiding behaviors were related to higher body mass index (BMI). Children participated in few formal and informal physically active recreation activities. Sensory seeking behaviors were associated with increased participation in informal activities, and higher BMI was associated with less participation in both formal and informal activities. Practitioners should consider sensory processing patterns and BMI when developing community-based programs to promote physical activity of children with ASD. PMID:27548863

  6. Participation in leisure activities among boys with attention deficit hyperactivity disorder.

    PubMed

    Shimoni, Ma'ayan; Engel-Yeger, Batya; Tirosh, Emanuel

    2010-01-01

    ADHD is a neural developmental disorder expressed in various life settings. Yet, previous studies have focused mainly on children's function in school and academic achievement. The purpose of the present study was, therefore, to examine participation patterns in outside formal school activities among boys with ADHD compared to typical boys. Participants included 25 boys aged 8-11 years with ADHD and 25 age-matched typical boys. All participants completed the Children's Assessment of Participation and Enjoyment (CAPE). Several aspects of participation were examined: diversity, intensity, enjoyment, place, and partners in 49 extra curricular activities. The findings indicate that boys with ADHD reported significant lower intensity rates of participation in most activity domains. Furthermore, boys with ADHD also reported higher diversity scores and lower enjoyment in 'formal' activities. Yet, no significant differences were found with regard to activity place and partners. These findings enhance the importance of providing therapy that refers to after school activities. Accordingly, CAPE can be useful for assessing boys with ADHD and planning appropriate intervention programs. PMID:20705424

  7. Alamethicin-like behaviour of new 18-residue peptaibols, trichorzins PA. Role of the C-terminal amino-alcohol in the ion channel forming activity.

    PubMed

    Duval, D; Cosette, P; Rebuffat, S; Duclohier, H; Bodo, B; Molle, G

    1998-03-01

    The influences of peptide length, absence of a Glx (Gln/Glu) residue and the C-terminal amino alcohol on liposome permeabilization and ion-channel characteristics in planar lipid bilayers were examined with two 18-residue peptaibols, PA V and PA IX. As compared to the 20-residue alamethicin, both peptides belonging to the newly isolated trichorzin family, lack a proline in the N-terminal part and one of the two Gln/Glu residues in the C-terminal part of the sequence. The two analogues studied here differ among themselves in their C-terminal amino alcohol (tryptophanol for PA V and phenylalaninol for PA IX). These alpha-helical peptaibols modify to a similar extent the permeability of liposomes, as measured by leakage of a previously entrapped fluorescent probe. Monitoring tryptophanol fluorescence, a greater embedment of the peptide PA V is observed in cholesterol-free bilayers. Macroscopic conductance studies for PA V and PA IX display alamethicin-like current-voltage curves, with a similar voltage dependence, but a smaller mean number of monomers per conducting aggregate is estimated for the tryptophanol analogue, PA V. Single-channel recordings indicate faster current fluctuations for PA IX, while amplitude histograms show lower conductance levels for PA V. Apart from underlining the role of the mismatch between helix length and bilayer hydrophobic thickness, these results stress that the C-terminal tryptophanol favours a stabilization of the conducting aggregates. PMID:9518665

  8. Participation in Daily Activities of Young Adults with High Functioning Autism Spectrum Disorder.

    PubMed

    McCollum, Mary; LaVesser, Patti; Berg, Christine

    2016-03-01

    Young adults with an autism spectrum disorder (ASD) struggle to assume adult roles. This research assessed the feasibility of using the Adolescent and Young Adult Activity Card Sort (AYA-ACS) with emerging adults with high functioning ASD. Two phases were utilized during this research: (1) comparing the activity participation reported by emerging adults with an ASD and that reported by their caring adult; (2) examining the barriers to participation reported. Preliminary results demonstrate that the AYA-ACS appears to be a reliable and valid method of identifying emerging adults' participation strengths as well as personal and environmental challenges in a variety of age-appropriate activities. The AYA-ACS could assist service providers by providing an understanding of the challenges to participation faced by this population and aid in developing client centered interventions.

  9. Restrictions of physical activity participation in older adults with disability: employing keyword network analysis

    PubMed Central

    Koo, Kyo-Man; Kim, Chun-Jong; Park, Chae-Hee; Byeun, Jung-Kyun; Seo, Geon-Woo

    2016-01-01

    Older adults with disability might have been increasing due to the rapid aging of society. Many studies showed that physical activity is an essential part for improving quality of life in later lives. Regular physical activity is an efficient means that has roles of primary prevention and secondary prevention. However, there were few studies regarding older adults with disability and physical activity participation. The purpose of this current study was to investigate restriction factors to regularly participate older adults with disability in physical activity by employing keyword network analysis. Two hundred twenty-nine older adults with disability who were over 65 including aging with disability and disability with aging in type of physical disability and brain lesions defined by disabled person welfare law partook in the open questionnaire assessing barriers to participate in physical activity. The results showed that the keyword the most often used was ‘Traffic’ which was total of 21 times (3.47%) and the same proportion as in the ‘personal’ and ‘economical’. Exercise was considered the most central keyword for participating in physical activity and keywords such as facility, physical activity, disabled, program, transportation, gym, discomfort, opportunity, and leisure activity were associated with exercise. In conclusion, it is necessary to educate older persons with disability about a true meaning of physical activity and providing more physical activity opportunities and decreasing inconvenience should be systematically structured in Korea. PMID:27656637

  10. Restrictions of physical activity participation in older adults with disability: employing keyword network analysis.

    PubMed

    Koo, Kyo-Man; Kim, Chun-Jong; Park, Chae-Hee; Byeun, Jung-Kyun; Seo, Geon-Woo

    2016-08-01

    Older adults with disability might have been increasing due to the rapid aging of society. Many studies showed that physical activity is an essential part for improving quality of life in later lives. Regular physical activity is an efficient means that has roles of primary prevention and secondary prevention. However, there were few studies regarding older adults with disability and physical activity participation. The purpose of this current study was to investigate restriction factors to regularly participate older adults with disability in physical activity by employing keyword network analysis. Two hundred twenty-nine older adults with disability who were over 65 including aging with disability and disability with aging in type of physical disability and brain lesions defined by disabled person welfare law partook in the open questionnaire assessing barriers to participate in physical activity. The results showed that the keyword the most often used was 'Traffic' which was total of 21 times (3.47%) and the same proportion as in the 'personal' and 'economical'. Exercise was considered the most central keyword for participating in physical activity and keywords such as facility, physical activity, disabled, program, transportation, gym, discomfort, opportunity, and leisure activity were associated with exercise. In conclusion, it is necessary to educate older persons with disability about a true meaning of physical activity and providing more physical activity opportunities and decreasing inconvenience should be systematically structured in Korea. PMID:27656637

  11. Restrictions of physical activity participation in older adults with disability: employing keyword network analysis

    PubMed Central

    Koo, Kyo-Man; Kim, Chun-Jong; Park, Chae-Hee; Byeun, Jung-Kyun; Seo, Geon-Woo

    2016-01-01

    Older adults with disability might have been increasing due to the rapid aging of society. Many studies showed that physical activity is an essential part for improving quality of life in later lives. Regular physical activity is an efficient means that has roles of primary prevention and secondary prevention. However, there were few studies regarding older adults with disability and physical activity participation. The purpose of this current study was to investigate restriction factors to regularly participate older adults with disability in physical activity by employing keyword network analysis. Two hundred twenty-nine older adults with disability who were over 65 including aging with disability and disability with aging in type of physical disability and brain lesions defined by disabled person welfare law partook in the open questionnaire assessing barriers to participate in physical activity. The results showed that the keyword the most often used was ‘Traffic’ which was total of 21 times (3.47%) and the same proportion as in the ‘personal’ and ‘economical’. Exercise was considered the most central keyword for participating in physical activity and keywords such as facility, physical activity, disabled, program, transportation, gym, discomfort, opportunity, and leisure activity were associated with exercise. In conclusion, it is necessary to educate older persons with disability about a true meaning of physical activity and providing more physical activity opportunities and decreasing inconvenience should be systematically structured in Korea.

  12. Sensory modulation disorder: a risk factor for participation in daily life activities.

    PubMed

    Bar-Shalita, Tami; Vatine, Jean-Jacques; Parush, Shula

    2008-12-01

    Participation in childhood daily functional performance was examined in 78 children: 44 with sensory modulation disorder (SMD); (33 males, 11 females; mean age 7y 6mo [SD 1.20]) and 34 without SMD (18 males, 16 females; mean age 7y 8mo [SD 1.33]). Group classification was determined using two measures: the Short Sensory Profile (SSP) and the Full-form Sensory Profile. Parents completed a battery of caregiver questionnaires. Children with SMD scored significantly lower on all three participation scales than the control group. A high correlation was observed between level of activity performance of the Participation in Childhood Occupations Questionnaire (PICO-Q) and the SSP, and a moderate correlation was observed between the Enjoyment of Performance of the PICO-Q and the SSP. A low correlation was observed between Frequency of Performance of the PICO-Q and the SSP. Logistic regression indicated that all three participation scales (level of activity performance, level of enjoyment of the activity, and frequency of performance of the activity) are significantly associated with group classification, with odds ratios of 3.13, 2.05, and 1.73 respectively. These findings are the first, to our knowledge, to confirm claims of limited participation in daily activities among children with SMD. Our results have significant clinical implications and provide support for the need for practitioners and caregivers of children with SMD to facilitate participation.

  13. Development of the Oxford Participation and Activities Questionnaire: constructing an item pool

    PubMed Central

    Kelly, Laura; Jenkinson, Crispin; Dummett, Sarah; Dawson, Jill; Fitzpatrick, Ray; Morley, David

    2015-01-01

    Purpose The Oxford Participation and Activities Questionnaire is a patient-reported outcome measure in development that is grounded on the World Health Organization International Classification of Functioning, Disability, and Health (ICF). The study reported here aimed to inform and generate an item pool for the new measure, which is specifically designed for the assessment of participation and activity in patients experiencing a range of health conditions. Methods Items were informed through in-depth interviews conducted with 37 participants spanning a range of conditions. Interviews aimed to identify how their condition impacted their ability to participate in meaningful activities. Conditions included arthritis, cancer, chronic back pain, diabetes, motor neuron disease, multiple sclerosis, Parkinson’s disease, and spinal cord injury. Transcripts were analyzed using the framework method. Statements relating to ICF themes were recast as questionnaire items and shown for review to an expert panel. Cognitive debrief interviews (n=13) were used to assess items for face and content validity. Results ICF themes relevant to activities and participation in everyday life were explored, and a total of 222 items formed the initial item pool. This item pool was refined by the research team and 28 generic items were mapped onto all nine chapters of the ICF construct, detailing activity and participation. Cognitive interviewing confirmed the questionnaire instructions, items, and response options were acceptable to participants. Conclusion Using a clear conceptual basis to inform item generation, 28 items have been identified as suitable to undergo further psychometric testing. A large-scale postal survey will follow in order to refine the instrument further and to assess its psychometric properties. The final instrument is intended for use in clinical trials and interventions targeted at maintaining or improving activity and participation. PMID:26056503

  14. Trajectories of Organized Activity Participation Among Urban Adolescents: An Analysis of Predisposing Factors.

    PubMed

    Eisman, Andria B; Stoddard, Sarah A; Bauermeister, José A; Caldwell, Cleopatra H; Zimmerman, Marc A

    2016-01-01

    Organized activity participation provides important opportunities for adolescents to develop assets and resources related to positive youth development. Predisposing factors, in addition to sociodemographics and self-selection factors, may influence how youth participate over time. In this study, we used growth mixture modeling with longitudinal data from African American adolescents attending urban high schools in Flint, MI to identify subgroups of participation trajectories (Wave 1 N = 681, mean age at Wave 1 = 14.86 years, 51% female). We measured activity participation using psychological and behavioral engagement across multiple contexts over the 4 years of high school. We examined how predisposing risk and promotive factors were related to these trajectories, accounting for sociodemographic and self-selection factors. The results indicated three participation trajectories: a low group decreasing over time (74%), a moderate, consistent participation group (21%) and a moderate, increasing group (5%). More substance use was associated with lower odds of being in the moderate/consistent versus low/decreasing participation group. More parental support was associated with lower odds of being in the moderate/increasing versus the moderate/consistent group. Our results suggest that addressing predisposing factors such as substance use may help facilitate participation over time.

  15. Participation in Social Activities among Adolescents with an Autism Spectrum Disorder

    PubMed Central

    Shattuck, Paul T.; Orsmond, Gael I.; Wagner, Mary; Cooper, Benjamin P.

    2011-01-01

    Background Little is known about patterns of participation in social activities among adolescents with an autism spectrum disorder (ASD). The objectives were to report nationally representative (U.S.) estimates of participation in social activities among adolescents with an ASD, to compare these estimates to other groups of adolescents with disabilities, and examine correlates of limited social participation. Methods and Findings We analyzed data from wave 1 of the National Longitudinal Transition Study 2, a large cohort study of adolescents enrolled in special education. Three comparison groups included adolescents with learning disabilities, mental retardation, and speech/language impairments. Adolescents with an ASD were significantly more likely never to see friends out of school (43.3%), never to get called by friends (54.4%), and never to be invited to social activities (50.4%) when compared with adolescents from all the other groups. Correlates of limited social participation included low family income and having impairments in conversational ability, social communication, and functional cognitive skills. Conclusions Compared with prior research, our study significantly expands inquiry in this area by broadening the range of social participation indicators examined, increasing the external validity of findings, focusing on the under-studied developmental stage of adolescence, and taking an ecological approach that included many potential correlates of social participation. There were notable differences in social participation by income, a dimension of social context seldom examined in research on ASDs. PMID:22110612

  16. Beyond participation: the association between school extracurricular activities and involvement in violence across generations of immigration.

    PubMed

    Jiang, Xin; Peterson, Ruth D

    2012-03-01

    Participation in extracurricular activities is purported to protect the broad spectrum of youth from a host of behavioral risks. Yet, empirical research on the extent to which this assumption holds for involvement in violence by immigrant youth is limited. Thus, using data for 13,236 (51.8% female) adolescents from the National Longitudinal Study of Adolescent Health, this study explores how the relationship between extracurricular activities and youth violence varies by type of extracurricular activity profile (sports alone, non-sports alone, and a combination of sports and non-sports) and by generations of immigration (first, second, and third-plus). The sample is composed of 9.3% (n = 1,233) first-generation youth, 15.7% (n = 2,080) second generation, and 74.9% (n = 9,923) third-plus generation. The results reveal that adolescents from the third-plus generation (i.e., non-immigrant youth) who participate in non-sports alone or sports plus non-sports have lower odds of involvement in violence than adolescents from the same generation who do not participate in extracurricular activities. However, for first- and second-generation adolescents, participation in extracurricular activities is associated with higher rather than lower odds of violence compared to their non-participating counterparts. These findings challenge the viewpoint that participation in mainstream extracurricular activities as afforded by US schools is equally beneficial for all youth. They also call for additional research that explores why immigrant youth are less likely than non-immigrant youth to gain violence-reducing benefits when they participate in extracurricular activities.

  17. A combination of desmopressin and docetaxel inhibit cell proliferation and invasion mediated by urokinase-type plasminogen activator (uPA) in human prostate cancer cells

    SciTech Connect

    Sasaki, Hiroshi; Klotz, Laurence H.; Sugar, Linda M.; Kiss, Alexander; Venkateswaran, Vasundara

    2015-08-28

    Background: This study was designed to assess the effectiveness of a combination treatment using both desmopressin and docetaxel in prostate cancer treatment. Desmopressin is a well-known synthetic analogue of the antidiuretic hormone vasopressin. It has recently been demonstrated to inhibit tumor progression and metastasis in in vivo models. Docetaxel is widely used for the treatment of castration resistant prostate cancer (CRPC) patients. However, durable responses have been uncommon to date. In this study, we investigated the anti-tumor effect of desmopressin in combination with docetaxel in vitro and in vivo. Methods: Two prostate cancer cells (PC3, LNCaP) were treated with different concentrations of desmopressin alone, docetaxel alone, and a combination of desmopressin and docetaxel. Cell proliferation was determined by MTS assay. The anti-invasive and anti-migration potential of desmopressin and in combination with docetaxel were examined by wound healing assay, migration chamber assay, and matrigel invasion assay. Results: The combination of desmopressin and docetaxel resulted in a significant inhibition of PC3 and LNCaP cell proliferation (p < 0.01). Additionally, cell migration and invasion were also inhibited by the combination when compared to that of either treatment alone in PC3 cells (p < 0.01). The anti-tumor effect of this combination treatment was associated with down-regulation of both urokinase-type plasminogen activator (uPA) and matrix metalloproteinase (MMP-2 and MMP-9) in PC3 cells. Conclusions: We are the first to elucidate the anti-tumor and anti-metastatic potential of desmopressin in combination with docetaxel in a prostate cancer model via the uPA-MMP pathway. Our finding could potentially contribute to the therapeutic profile of desmopressin and enhance the efficacy of docetaxel based treatment for CRPC. - Highlights: • Desmopressin inhibits cell proliferation in prostate cancer cells. • The expression of cyclin A and CDK2

  18. Motor speech impairment, activity, and participation in children with cerebral palsy.

    PubMed

    Mei, Cristina; Reilly, Sheena; Reddihough, Dinah; Mensah, Fiona; Morgan, Angela

    2014-08-01

    The present study used a population-based sample of children with cerebral palsy (CP) to estimate the prevalence of motor speech impairment and its association with activity and participation. A sample of 79 Victorian children aged 4 years 11 months to 6 years 5 months was recruited through the Victorian CP Register. The presence of motor speech impairment was recorded using the Viking Speech Scale (VSS). Activity and participation outcomes included speech intelligibility (the National Technical Institute for the Deaf rating scale, NTID), the Functional Communication Classification System (FCCS) and Communication Function Classification System (CFCS). A parent completed rating scale was used to examine the association between motor speech impairment and participation. Ninety per cent (71/79) of children demonstrated a motor speech impairment. Strong associations were found between the VSS and NTID (< .001), CFCS (< .001), and FCCS levels (<.001). VSS levels III-IV were significantly associated with restrictions in home, school, and community-based participation as perceived by parents. Although some diversity in activity and participation outcomes was observed within specific VSS levels, the results of this study suggested that children with mild motor speech impairments are more likely to demonstrate superior activity and participation outcomes compared to children with moderate or severe deficits.

  19. [Male participation in types of physical activities of a program for the elderly: a longitudinal study].

    PubMed

    Medeiros, Paulo Adão de; Streit, Inês Amanda; Sandreschi, Paula Fabricio; Fortunato, Artur Rodrigues; Mazo, Giovana Zarpellon

    2014-08-01

    The article seeks to describe male participation on a physical activity program for the elderly in the south of Brazil over a ten-year period (2003-2013). The data of the study were extracted from a database and assessed using descriptive and inferential statistics and assessment of the thematic content. The first phase of the study was longitudinal (from 2003 to 2013) with 163 elderly participants, while the second phase was cross-sectional for the year of 2013 with 45 elderly individuals. Male participation was, on average, 3.5 times lower than female participation for all years assessed, and the activity most practiced was swimming. In the year 2013, the average age of the elderly men was 68 ± 7.8 years. Most of them are married, have tertiary education, good acquisitive power, positive self perception of health, one or more diagnosed diseases, and do not participate in any other physical activity outside the program. According to the elderly, the reasons for participating most cited was the search for quality of life and health and, for continuing to exercise, acquiring the taste for the physical activity. Understanding the profile of these individuals and of the reasons that motivate them are important tools to comprehend the issue and help to define public politics directed at this population group. PMID:25119086

  20. Feasibility and Effects of Short Activity Breaks for Increasing Preschool-Age Children's Physical Activity Levels

    ERIC Educational Resources Information Center

    Alhassan, Sofiya; Nwaokelemeh, Ogechi; Mendoza, Albert; Shitole, Sanyog; Puleo, Elaine; Pfeiffer, Karin A.; Whitt-Glover, Melicia C.

    2016-01-01

    Background: We examined the effects of short bouts of structured physical activity (SBS-PA) implemented within the classroom setting as part of designated gross-motor playtime on preschoolers PA. Methods: Preschools were randomized to SBS-PA (centers, N = 5; participants, N = 141) or unstructured free playtime (UPA) (centers, N = 5; participants,…

  1. Extracurricular Activities, Athletic Participation, and Adolescent Alcohol Use: Gender-Differentiated and School-Contextual Effects

    ERIC Educational Resources Information Center

    Hoffmann, John P.

    2006-01-01

    This research investigates the effects of extracurricular activities on alcohol use among male (n = 4,495) and female (n = 5,398) adolescents who participated in the 1990-92 National Education Longitudinal Study. Previous studies have assessed the association between extracurricular activities and alcohol use, but none have explored whether the…

  2. Participation in Daily Activities of Young Adults with High Functioning Autism Spectrum Disorder

    ERIC Educational Resources Information Center

    McCollum, Mary; LaVesser, Patti; Berg, Christine

    2016-01-01

    Young adults with an autism spectrum disorder (ASD) struggle to assume adult roles. This research assessed the feasibility of using the Adolescent and Young Adult Activity Card Sort (AYA-ACS) with emerging adults with high functioning ASD. Two phases were utilized during this research: (1) comparing the activity participation reported by emerging…

  3. Arranging Instruction to Ensure the Active Participation of Severely Multihandicapped Students.

    ERIC Educational Resources Information Center

    Ford, Alison; And Others

    This task force report considers strategies designed to elicit active participation on the part of severely multihandicapped students. The first section considers ways to gather information on environments and daily activities of severely multihandicapped students. Hypothetical daily home and vocational routines were composed and estimates made of…

  4. Young School-Aged Children's Behaviour and Their Participation in Extra-Curricular Activities

    ERIC Educational Resources Information Center

    Simoncini, Kym; Caltabiono, Nerina

    2012-01-01

    While research has repeatedly shown the benefits of participation in extracurricular activities for adolescents, few studies have focused on very young children. Extra-curricular activities afford children opportunities for development and can also influence their behaviour. Children's behaviour is an important predictor of their future successes…

  5. Promoting Active Participation in Book Reading for Preschoolers with Autism Spectrum Disorder: A Preliminary Study

    ERIC Educational Resources Information Center

    Fleury, Veronica P.; Miramontez, Shane Herriott; Hudson, Roxanne F.; Schwartz, Ilene S.

    2014-01-01

    A common literacy practice in early childhood classrooms is reading aloud to children. Little is known, however, about the quality of engagement in shared reading activities for young children with Autism Spectrum Disorders (ASD). Dialogic reading is one method of shared reading in which adults encourage children to actively participate in the…

  6. Student Learning through Participation in Inquiry Activities: Two Case Studies in Teacher and Computer Engineering Education

    ERIC Educational Resources Information Center

    Damsa, Crina I.; Nerland, Monika

    2016-01-01

    The two case studies reported in this article contribute to a better understanding of how inquiry tasks and activities are employed as resourceful means for learning in higher professional education. An observation-based approach was used to explore characteristics of and challenges in students' participation in collaborative inquiry activities in…

  7. A Literature Review of the Impact of Extracurricular Activities Participation on Students' Academic Performance

    ERIC Educational Resources Information Center

    Seow, Poh-Sun; Pan, Gary

    2014-01-01

    Extracurricular activities (ECA) have become an important component of students' school life and many schools have invested significant resources on extracurricular activities. The authors suggest three major theoretical frameworks (zero-sum, developmental, and threshold) to explain the impact of ECA participation on students' academic…

  8. Secondary School Students' Physical Activity Participation across Physical Education Classes: The Expectancy-Value Theory Approach

    ERIC Educational Resources Information Center

    Gråstén, Arto; Watt, Anthony; Hagger, Martin; Jaakkola, Timo; Liukkonen, Jarmo

    2015-01-01

    The primary purpose of this study was to analyze the link between students' expectancy beliefs, subjective task values, out-of-school activity, and moderate to vigorous physical activity (MVPA) participation across secondary school physical education (PE) classes. The sample comprised 96 students (58 girls, 38 boys; Mage = 15.03, SD = 0.94) from…

  9. A population-based profile of adult Canadians living with participation and activity limitations

    PubMed Central

    Goodridge, Donna; Lawson, Josh; Marciniuk, Darcy; Rennie, Donna

    2011-01-01

    Background: Currently, one out of every seven Canadians is affected by limitations to their participation and activity. This study describes the self-reported main causes of these limitations in a national sample. Methods: The 2006 Participation and Activity Limitation Survey was a two-phase stratified survey based on filter questions posed in the 2006 Census of Population conducted by Statistics Canada. Respondents to the survey represent 5 185 980 Canadian adults with activity and participation limitations. We used these data to develop a profile of our population of interest: adult Canadians with activity and participation limitations. Associations between demographic variables and self-reported causes of activity and participation limitations were assessed using multiple logistic regression. Results: One quarter of participants did not attribute their disability to any medical cause. The most prevalent medical conditions to which disabilities were attributed were musculoskeletal (46.1%), cardio/cerebrovascular (12.3%), mental health (8.4%), neurologic (6.0%), endocrine (6.0%) and respiratory (4.5%) conditions. Significant associations were noted between sociodemographic variables and participants’ attributions of medical conditions as cause of disability. Multiple logistic regression with bootstrapping showed that people who reported a medical cause for their limitation were more likely (p < 0.05) to be female, widowed, 40 years of age or older, born in Canada or white and were less likely (p < 0.05) to be in the highest income category or to be employed (i.e., to work more than 0 h/w). Interpretation: Most people living with activity and participation limitations report having a musculoskeletal disorder. However, a significant proportion of respondants did not attribute their limitations to a medical cause. PMID:21825051

  10. Female participation in housing activities: some assessment of the socio-economic and cultural impact.

    PubMed

    Mujahid-mukhtar, E; Noor-ul-hassan

    1992-01-01

    Ordinary least squares techniques (logit and probit models yielded similar results) were used to assess the impact of sociocultural and economic conditions on women's physical or financial involvement in housing activities: construction, repairs, improvements, and additions in Pakistan. Explanatory variables were the number of men and women, family income, employment, literacy, extended family on the same or different budget, decision making by women, joint decision making, urbanization, and ethnic origin. Data were obtained from a survey undertaken by the AERC/World Bank in 1989 of 829 households (370 urban and 454 rural). A description is provided of women's role in housing, the nature of activities in which women participate, and the factors that influence their participation. Women's participation could involve decision making, contributions of assets or savings, and/or physical labor or supervision of physical construction of housing. The results indicated a uniform pattern in the performance of explanatory variables. Financially, urban women tended to participate more in financial dealings than rural women. Significant explanatory factors impacting on the proportion of women contributing financially toward housing were women's own income, their employment, their involvement in decision making for that activity, their nuclear household, and an urban location. A significant negative factor was family size. Literacy had no effect. Rural women tended to participate more in the physical construction of housing than urban women. Positive impacts on physical participation were a nuclear household, women's involvement in decision making, her employment, and a rural location. Literacy had a significant negative influence on physical participation. Unexpectedly, the number of adult females had a significant negative effect on physical or supervisory participation; the number of adult males was positive and insignificant. Factors influencing women's supervisory

  11. Early psychosis, activity performance and social participation: a conceptual model to guide rehabilitation and recovery.

    PubMed

    Woodside, Harriet; Krupa, Terry; Pocock, Karen

    2007-01-01

    In this paper we present a conceptual model focusing on activity performance and social participation of individuals in the period prior to their first acute episodes of psychosis. The model was developed using the constructivist grounded theory method. Data from interviews and documents was collected from 25 primary participants. Interviews were also conducted with 15 members of the participants' support networks and six experts in the field of early psychosis and rehabilitation. The model illustrates how the core constructs of activity performance and social participation are set against the natural context and influenced by shifts in three determinants: faltering personal capacities, negotiating for success and risk factors. The model suggests rehabilitation and recovery practices in early intervention work. PMID:18018956

  12. Relationship between activity limitations and participation restriction in school-aged children with cerebral palsy

    PubMed Central

    Park, Eun-Young; Kim, Won-Ho

    2015-01-01

    [Purpose] This study investigated the relationship between activity limitation and participation restriction in school-aged children with cerebral palsy. [Subjects and Methods] Data were collected from 109 children with cerebral palsy aged 6–12 years. Activity limitations were assessed by using functional classification systems including the Korean-Gross Motor Function Classification System, the Korean-Manual Ability Classification System, and the Korean-Communication Function Classification System. Participation restriction was measured using the Korean-Frequency of Participation Questionnaire. Physical or occupational therapists and parents collected the data. [Results] All levels of the functional classification systems were significantly negatively correlated with Korean-Frequency of Participation Questionnaire ratings (r= −0.382 to −0.477). The Korean-Frequency of Participation Questionnaire ratings differed significantly with respect to the functional classification systems; in particular, the differences in the ratings of levels I and V were significant. The Korean-Communication Function Classification System and Korean-Gross Motor Function Classification System were significant predictors of participation, explaining 26.5% of the variance. [Conclusion] Intervention programs are required to promote communication skills and gross motor ability in order to improve the participation of children with cerebral palsy. PMID:26357445

  13. Participation in School Food and Nutrition Activities among Grade 6-8 Students in Vancouver.

    PubMed

    Stephens, Teya A; Black, Jennifer L; Chapman, Gwen E; Velazquez, Cayley E; Rojas, Alejandro

    2016-07-01

    This study examined student-reported participation in school food and nutrition activities in Vancouver, British Columbia (BC), and whether engagement differed by gender and between elementary and secondary school students. A cross-sectional survey of grade 6-8 public school students (n = 937) from 20 elementary and 6 secondary schools assessed student-reported participation in a range of food and nutrition activities. Statistical analyses included descriptive statistics and multilevel logistic regression to examine associations between participation with gender and school type. Overall, <50% of students reported engaging in most of the food and nutrition activities examined in the 2011-2012 school year, including: food preparation (36%), choosing/tasting healthy foods (27%), learning about Canada's Food Guide (CFG) (45%), learning about foods grown in BC (35%), gardening (21%), composting (32%), and recycling (51%). Females were more likely to report recycling and learning about CFG and BC-grown foods (P < 0.05). Secondary students were more likely to report activities focused on working with or learning about food/nutrition (P < 0.05). Despite local and provincial efforts to engage students in food and nutrition experiences, participation in most activities remains relatively low, with few students exposed to multiple activities. Continued advocacy is needed from the dietetics community to improve student engagement in food and nutrition activities. PMID:27182726

  14. Evaluating the ParticipACTION "Think Again" Campaign

    ERIC Educational Resources Information Center

    Gainforth, Heather L.; Jarvis, Jocelyn W.; Berry, Tanya R.; Chulak-Bozzer, Tala; Deshpande, Sameer; Faulkner, Guy; Rhodes, Ryan E.; Spence, John C.; Tremblay, Mark S.; Latimer-Cheung, Amy E.

    2016-01-01

    Introduction: ParticipACTION's 2011 "Think Again" campaign aimed to draw parents', and specifically mothers', attention to the amount of physical activity (PA) their children do relative to the national guidelines (physical activity guidelines [PAG]). Purpose: To evaluate ParticipACTION's "Think Again" campaign in the context…

  15. Physical activity research in Hong Kong from 1987 to 2012: evidence on children and adolescents.

    PubMed

    He, Gang; Huang, Wendy Yajun; Wong, Stephen H

    2014-11-01

    A comprehensive understanding of research on the physical activity (PA) of Hong Kong youth is necessary to develop specific and effective intervention strategies. This review summarizes existing evidence in studies on PA among the Hong Kong youth. An electronic literature search was conducted using MEDLINE, SPORTDiscus, ERIC, and HighWire database. Forty-five studies published from 1987 to 2012 were included in this review. The findings are presented in five categories, namely, health benefits of PA, participation in PA, assessment of PA, correlates of PA, and interventions to promote PA. The results indicate that PA among the youth in Hong Kong has attracted concern in the past decade. Specifically, extensive studies focused on the areas of health benefits of PA, participation in PA, and correlates of PA. Research into context-specific correlates of PA and tailored PA promotion programs for the Hong Kong youth is warranted in the future.

  16. The Relationship of Participation in Extracurricular Activities to Student Achievement, Student Attendance, and Student Behavior in a Nebraska School District

    ERIC Educational Resources Information Center

    Dick, Andrew D.

    2010-01-01

    The purpose of this study was to examine possible relationships between participation in extracurricular activities and student achievement, participation in extracurricular activities and attendance, and participation in extracurricular activities and behavior. The setting for this study was a high school in western Nebraska. Data for 275 of the…

  17. Associations of Physical Activity, Sports Participation and Active Commuting on Mathematic Performance and Inhibitory Control in Adolescents

    PubMed Central

    Huang, Tao; Gejl, Anne Kær; Froberg, Karsten

    2016-01-01

    Objectives To examine objectively measured physical activity level, organized sports participation and active commuting to school in relation to mathematic performance and inhibitory control in adolescents. Methods The design was cross-sectional. A convenient sample of 869 sixth and seventh grade students (12–14 years) was invited to participate in the study. A total of 568 students fulfilled the inclusion criteria and comprised the final sample for this study. Mathematic performance was assessed by a customized test and inhibitory control was assessed by a modified Eriksen flanker task. Physical activity was assessed with GT3X and GT3X+ accelerometers presented in sex-specific quartiles of mean counts per minute and mean minutes per day in moderate-to-vigorous physical activity. Active commuting and sports participation was self-reported. Mixed model regression was applied. Total physical activity level was stratified by bicycling status in order to bypass measurement error subject to the accelerometer. Results Non-cyclists in the 2nd quartile of counts per minute displayed a higher mathematic score, so did cyclists in the 2nd and 3rd quartile of moderate-to-vigorous physical activity relative to the least active quartile. Non-cyclists in the 3rd quartile of counts per minute had an improved reaction time and cyclists in the 2nd quartile of counts per minute and moderate-to-vigorous physical activity displayed an improved accuracy, whereas non-cyclists in the 2nd quartile of counts per minute showed an inferior accuracy relative to the least active quartile. Bicycling to school and organized sports participation were positively associated with mathematic performance. Conclusions Sports participation and bicycling were positively associated with mathematic performance. Results regarding objectively measured physical activity were mixed. Although, no linear nor dose-response relationship was observed there was no indication of a higher activity level impairing the

  18. Democracy to Come: Active Forums as Indicator Suites for e-Participation and e-Governance

    NASA Astrophysics Data System (ADS)

    Rodan, Debbie; Balnaves, Mark

    There is in modern industrial societies a ‘civic deficit’ Civic engagement in the traditional sense of community values and civic participation is declining (Putman 2000). What has not been examined is the ways in which various media including new media may provide real options for participatory cultures and participatory democracy now and in the future. Undoubtedly there are differences between participatory cultures that are considered a ‘genuine’ contribution to representational democracy and those that are not. This paper, based on initial research into Internet activism, will examine GetUp! as a specific example of an active forum that the authors argue enable participatory citizenship through media participation. While there are very few examples of active forums that might be considered a ‘genuine’ contribution to representational democracy there are clear signals that activism through active forums is maturing into a potent democratic force.

  19. Parent influences on physical activity participation and physical fitness of deaf children.

    PubMed

    Ellis, M Kathleen; Lieberman, Lauren J; Dummer, Gail M

    2014-04-01

    Research has consistently demonstrated that parents' values toward physical activity and fitness have strongly influenced the physical activity habits of hearing children (Welk, G. J., Wood, K., & Morss, G. [2003]. Parental influences on physical activity in children: An exploration of potential mechanisms. Pediatric Exercise Science, 15, 19-33). The primary purpose of this study was to determine whether similar findings are obtained for deaf (1) children. The influence of parents' hearing status and parents' involvement in Deaf sport (2) was assessed in addition to their values toward sports participation and physical fitness for their deaf children. Deaf children's physical activity habits were determined by the number of activities participated per week, and fitness levels by the number of scores within the Healthy Fitness Zone from the Fitnessgram test. Parents demonstrated positive values toward physical fitness regardless of hearing status; this finding was strongest among deaf parents of deaf children. Significant positive relationships were found among parents' values toward physical fitness and sport participation and children's physical activity and fitness levels, as well as between Deaf sport involvement by deaf parents and children's physical activity levels.

  20. Modelling the participation decision and duration of sporting activity in Scotland

    PubMed Central

    Eberth, Barbara; Smith, Murray D.

    2010-01-01

    Motivating individuals to actively engage in physical activity due to its beneficial health effects has been an integral part of Scotland's health policy agenda. The current Scottish guidelines recommend individuals participate in physical activity of moderate vigour for 30 min at least five times per week. For an individual contemplating the recommendation, decisions have to be made in regard of participation, intensity, duration and multiplicity. For the policy maker, understanding the determinants of each decision will assist in designing an intervention to effect the recommended policy. With secondary data sourced from the 2003 Scottish Health Survey (SHeS) we statistically model the combined decisions process, employing a copula approach to model specification. In taking this approach the model flexibly accounts for any statistical associations that may exist between the component decisions. Thus, we model the endogenous relationship between the decision of individuals to participate in sporting activities and, amongst those who participate, the duration of time spent undertaking their chosen activities. The main focus is to establish whether dependence exists between the two random variables assuming the vigour with which sporting activity is performed to be independent of the participation and duration decision. We allow for a variety of controls including demographic factors such as age and gender, economic factors such as income and educational attainment, lifestyle factors such as smoking, alcohol consumption, healthy eating and medical history. We use the model to compare the effect of interventions designed to increase the vigour with which individuals undertake their sport, relating it to obesity as a health outcome. PMID:20640033

  1. Modeling a 15-min extravehicular activity prebreathe protocol using NASA's exploration atmosphere (56.5 kPa/34% O2)

    NASA Astrophysics Data System (ADS)

    Abercromby, Andrew F. J.; Conkin, Johnny; Gernhardt, Michael L.

    2015-04-01

    NASA's plans for future human exploration missions utilize a new atmosphere of 56.5 kPa (8.2 psia), 34% O2, 66% N2 to enable rapid extravehicular activity (EVA) capability with minimal gas losses; however, existing EVA prebreathe protocols to mitigate risk of decompression sickness (DCS) are not applicable to the new exploration atmosphere. We provide preliminary analysis of a 15-min prebreathe protocol and examine the potential benefits of intermittent recompression (IR) and an abbreviated N2 purge on crew time and gas consumables usage. A probabilistic model of decompression stress based on an established biophysical model of DCS risk was developed, providing significant (p<0.0001) prediction and goodness-of-fit with 84 cases of DCS in 668 human altitude exposures including a variety of pressure profiles. DCS risk for a 15-min prebreathe protocol was then estimated under different exploration EVA scenarios. Estimated DCS risk for all EVA scenarios modeled using the 15-min prebreathe protocol ranged between 6.1% and 12.1%. Supersaturation in neurological tissues (5- and 10-min half-time compartments) is prevented and tissue tensions in faster half-time compartments (≤40 min), where the majority of whole-body N2 is located, are reduced to about the levels (30.0 vs. 27.6 kPa) achieved during a standard Shuttle prebreathe protocol. IR reduced estimated DCS risk from 9.7% to 7.9% (1.8% reduction) and from 8.4% to 6.1% (2.3% reduction) for the scenarios modeled; the penalty of N2 reuptake during IR may be outweighed by the benefit of decreased bubble size. Savings of 75% of purge gas and time (0.22 kg gas and 6 min of crew time per person per EVA) are achievable by abbreviating the EVA suit purge to 20% N2 vs. 5% N2 at the expense of an increase in estimated DCS risk from 9.7% to 12.1% (2.4% increase). A 15-min prebreathe protocol appears feasible using the new exploration atmosphere. IR between EVAs may enable reductions in suit purge and prebreathe requirements

  2. The Impact of Education on Rural Women's Participation in Political and Economic Activities

    ERIC Educational Resources Information Center

    Bishaw, Alemayehu

    2014-01-01

    This study endeavored to investigate the impact of education on rural women's participation in political and economic activities. Six hundred rural women and 12 gender Activists were selected for this study from three Zones of Amhara Region, Ethiopia using multi-stage random sampling technique and purposeful sampling techniques respectively.…

  3. Adolescent Developmental Experiences and Participation in Extracurricular Activities in Saudi Arabia

    ERIC Educational Resources Information Center

    Alfnifie, Shuaa

    2012-01-01

    This study examined adolescent developmental experiences and participation in extracurricular activities. Providing youth with multiple channels to nurture their development and acknowledge their interests and strengths can play a significant role in their holistic growth. This is a descriptive study of a mixed-methods design (quantitative and…

  4. Toward Enriched Conceptions of Work Learning: Participation, Expansion, and Translation among Individuals with/in Activity

    ERIC Educational Resources Information Center

    Fenwick, Tara

    2006-01-01

    This article argues that understandings of work learning within human resource development (HRD) theory can be fruitfully enriched by more fully incorporating practice-based perspectives. Three contemporary theories that analyze learning as a relation of individuals with and/or in activity are discussed: the participational perspective of situated…

  5. Conceptual and Methodological Considerations in Self-Concept and Participation in School Activities Reanalyzed.

    ERIC Educational Resources Information Center

    Gauthier, William J., Jr.; Yaworth, Joseph S.

    1980-01-01

    Winne and Walsh's Reanalysis (EJ 229 157) of Gauthier and Yarworth's study of self-concept and participation in high school activities (EJ 189 606) is addressed, particularly with respect to the statistical techniques used. The intentions of the original article are also clarified. (GDC)

  6. Energy Efficiency in Gait, Activity, Participation, and Health Status in Children with Cerebral Palsy

    ERIC Educational Resources Information Center

    Kerr, Claire; Parkes, Jackie; Stevenson, Mike; Cosgrove, Aidan P.; McDowell, Brona C.

    2008-01-01

    The aim of the study was to establish if a relationship exists between the energy efficiency of gait, and measures of activity limitation, participation restriction, and health status in a representative sample of children with cerebral palsy (CP). Secondary aims were to investigate potential differences between clinical subtypes and gross motor…

  7. Inequity outside the Classroom: Growing Class Differences in Participation in Extracurricular Activities

    ERIC Educational Resources Information Center

    Snellman, Kaisa; Silva, Jennifer M.; Putnam, Robert D.

    2015-01-01

    In this article, the authors report on research that shows that extracurricular activities help cultivate the skills, connections, and knowledge that prepare children for lifelong success. They add, however, that low-income students are increasingly being excluded from participating. Struggling with budget cuts and deficits, many school districts…

  8. Predisposing, Reinforcing and Enabling Predictors of Middle School Children's After-School Physical Activity Participation

    ERIC Educational Resources Information Center

    King, Kristi M.; Ogletree, Roberta J.; Fetro, Joyce V.; Brown, Stephen L.; Partridge, Julie A.

    2011-01-01

    Children's participation in after-school physical activity can attenuate the overweight and obesity rates among rural, low socioeconomic status (SES) children. Children's individual determination, as well as social and environmental factors, can influence their behaviors. Purpose: The purposes of this study were to determine if a difference…

  9. Activities and Participation in Children with Developmental Coordination Disorder: A Systematic Review

    ERIC Educational Resources Information Center

    Magalhaes, L. C.; Cardoso, A. A.; Missiuna, C.

    2011-01-01

    Purpose: To systematically review all literature published in peer reviewed journals from January 1995 to July 2008 in order to summarize and describe the activity limitations and participation restrictions of children with developmental coordination disorder (DCD). Methods: Multiple databases were systematically searched for articles related to…

  10. Description of Functional Disability among Younger Stroke Patients: Exploration of Activity and Participation and Environmental Factors

    ERIC Educational Resources Information Center

    Snogren, Maria; Sunnerhagen, Katharina Stibrant

    2009-01-01

    The aim of the study is to describe disability among younger stroke patients by analyzing activity and participation and the environmental aspect as well as to compare assessed and self-perceived problems after stroke. International Classification of Functioning and Health (ICF) is a tool that provides a scientific basis for understanding and…

  11. Participation in Organized Activities and Conduct Problems in Elementary School: The Mediating Effect of Social Skills

    ERIC Educational Resources Information Center

    Denault, Anne-Sophie; Déry, Michèle

    2015-01-01

    The goal of this study was to test a mediation model in which social skills mediate the relationship between participation in organized activities and conduct problems among elementary school children. Two moderators of these associations were also examined, namely, gender and reception of special education services. A total of 563 children (45%…

  12. Developmental Coordination Disorder, Gender, and Body Weight: Examining the Impact of Participation in Active Play

    ERIC Educational Resources Information Center

    Cairney, John; Kwan, Matthew Y. W.; Hay, John A.; Faught, Brent E.

    2012-01-01

    Background: To examine whether differences in participation in active play (PAP) can account for gender differences in the relationship between Developmental Coordination Disorder (DCD) and body weight/fat (BMI and percentage fat) in youth. Methods: A cross-sectional investigation of students in grades four through eight (n = 590). Height, weight…

  13. Adolescent Expectancy-Value Motivation, Achievement in Physical Education, and Physical Activity Participation

    ERIC Educational Resources Information Center

    Zhu, Xihe; Chen, Ang

    2013-01-01

    This study examined the relation between adolescent expectancy-value motivation, achievements, and after-school physical activity participation. Adolescents (N = 854) from 12 middle schools completed an expectancy-value motivation questionnaire, pre and posttests in psychomotor skill and health-related fitness knowledge tests, and a three-day…

  14. Beyond Participation: The Association between School Extracurricular Activities and Involvement in Violence across Generations of Immigration

    ERIC Educational Resources Information Center

    Jiang, Xin; Peterson, Ruth D.

    2012-01-01

    Participation in extracurricular activities is purported to protect the broad spectrum of youth from a host of behavioral risks. Yet, empirical research on the extent to which this assumption holds for involvement in violence by immigrant youth is limited. Thus, using data for 13,236 (51.8% female) adolescents from the National Longitudinal Study…

  15. Socioemotional Behavior and School Achievement in Relation to Extracurricular Activity Participation in Middle Childhood

    ERIC Educational Resources Information Center

    Metsapelto, Riitta-Leena; Pulkkinen, Lea

    2012-01-01

    This 3-year longitudinal study investigated the associations of student (aged 9 to 10 years at the beginning of the study; n = 281; 51% girls) participation in extracurricular activities with teacher-rated socioemotional behavior and school achievement. MANOVA results showed that, after controlling for the grade level and the initial level of the…

  16. Factors of Participants and Blogs That Predict Blogging Activeness during Teaching Practice and Induction Year

    ERIC Educational Resources Information Center

    Luik, Piret; Taimalu, Merle

    2016-01-01

    The blog as a type of social software has been used in education for several years, and its positive effect in the field has been asserted in many studies. This study presents the factors of participants and blogs that predict blogging activeness during teaching practice and induction year. During the teaching practice and induction year all…

  17. Participation of Elderly Women in Community Welfare Activities in Akinyele Local Government, Oyo State, Nigeria

    ERIC Educational Resources Information Center

    Odebode, Stella O.

    2009-01-01

    This paper assessed the participation of elderly women in community welfare activities in Oyo State, Nigeria. Simple random sampling technique was used to select 120 elderly women from six out of the twelve political wards in the study area. Both qualitative and quantitative methods of data collection were used to elicit information from the…

  18. 7 CFR 621.40 - Participation in Federal interagency policy activities at the national level.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 6 2012-01-01 2012-01-01 false Participation in Federal interagency policy activities at the national level. 621.40 Section 621.40 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE WATER RESOURCES RIVER...

  19. 7 CFR 621.40 - Participation in Federal interagency policy activities at the national level.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false Participation in Federal interagency policy activities at the national level. 621.40 Section 621.40 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE WATER RESOURCES RIVER...

  20. Footballs versus Barbies: Childhood Play Activities as Predictors of Sport Participation by Women.

    ERIC Educational Resources Information Center

    Guiliano, Traci A.; Popp, Kathryn E.; Knight, Jennifer L.

    2000-01-01

    Examined the extent to which women's childhood play activities predicted future sport participation. College athletes and nonathletes completed a survey on childhood play and adult sports experiences. Playing with masculine toys and games, playing in predominantly male or mixed groups, and being a tomboy characterized women who later became…

  1. Moral Development and Identity Formation in High School Juniors: The Effects of Participation in Extracurricular Activities.

    ERIC Educational Resources Information Center

    Manners, Pamela A.; Smart, David J.

    The research described in this paper is from the fifth year of a 6-year longitudinal study investigating psychosocial and demographic factors associated with a wide range of behaviors among adolescents. The present analyses investigate the relationship between students' participation in extracurricular activities (athletic teams, musical groups,…

  2. Extracurricular Activity Participation of Hispanic Students: Implications for Social Capital Outcomes

    ERIC Educational Resources Information Center

    Villarreal, Victor; Gonzalez, Jorge E.

    2016-01-01

    The authors investigated whether participation in school-based extracurricular activities would predict social and behavioral outcomes (school membership, peer prosocial orientation, and prosocial behavior) associated with school social capital in a group of Hispanic middle school students from the United States of America. Results of hierarchical…

  3. What Do Mothers Say? Korean Mothers' Perceptions of Children's Participation in Extra-Curricular Musical Activities

    ERIC Educational Resources Information Center

    Cho, Eun

    2015-01-01

    A recent study of Korean middle-class mothers' perceptions and parenting practices associated with children's participation in musical activities reported unique forms of musical parenting, which closely correspond with previous studies of concerted cultivation in Western middle-class families. Are these unique patterns exclusive to middle-class…

  4. Physical Activity and Sport Participation in Youth with Congenital Heart Disease: Perceptions of Children and Parents

    ERIC Educational Resources Information Center

    Moola, Fiona; Faulkner, Guy E. J.; Kirsh, Joel A.; Kilburn, Jennifer

    2008-01-01

    This study explored perceptions toward physical activity and sport in the lives of youth with congenital heart disease. Thirteen cardiac participants were interviewed in the presence of their parents, and a process of inductive analysis was conducted. Sport was not considered a valued pursuit despite the belief that it is essential for the…

  5. Other-Repetition as a Resource for Participation in the Activity of Playing a Video Game

    ERIC Educational Resources Information Center

    Piirainen-Marsh, Arja; Tainio, Liisa

    2009-01-01

    This article offers an empirically based contribution to the growing body of studies using Conversation Analysis (CA) as a tool for analyzing second/foreign language learning in and through interaction. Building on a sociointeractional view of learning as grounded in the structures of participation in social activities, we apply CA methods to…

  6. Early-career registered nurses' participation in hospital quality improvement activities.

    PubMed

    Djukic, Maja; Kovner, Christine T; Brewer, Carol S; Fatehi, Farida K; Bernstein, Ilya

    2013-01-01

    We surveyed 2 cohorts of early-career registered nurses from 15 states in the US, 2 years apart, to compare their reported participation in hospital quality improvement (QI) activities. We anticipated differences between the 2 cohorts because of the growth of several initiatives for engaging nurses in QI. There were no differences between the 2 cohorts across 14 measured activities, except for their reported use of appropriate strategies to improve hand-washing compliance to reduce nosocomial infection rates. PMID:23192224

  7. Enabling Remote Activity: Using mobile technology for remote participation in geoscience fieldwork

    NASA Astrophysics Data System (ADS)

    Davies, Sarah; Collins, Trevor; Gaved, Mark; Bartlett, Jessica; Valentine, Chris; McCann, Lewis

    2010-05-01

    Field-based activities are regarded as essential to the development of a range of professional and personal skills within the geosciences. Students enjoy field activities, preferring these to learning with simulations (Spicer and Stratford 2001), and these improve deeper learning and understanding (Kern and Carpenter, 1984; Elkins and Elkins, 2007). However, some students find it difficult to access these field-based learning opportunities. Field sites may be remote and often require travel across uneven, challenging or potentially dangerous terrain. Mobility-impaired students are particularly limited in their opportunities to participate in field-based learning activities and, as higher education institutions have a responsibility to provide inclusive opportunities for students (UK Disability Discrimination Act 1995, UK Special Education Needs and Disability Rights Act 2001), the need for inclusive fieldwork learning is being increasingly recognised. The Enabling Remote Activity (ERA) project has been investigating how mobile communications technologies might allow field learning experiences to be brought to students who would otherwise find it difficult to participate, and also to enhance activities for all participants. It uses a rapidly deployable, battery-powered wireless network to transmit video, audio, and high resolution still images to connect participants at an accessible location with participants in the field. Crucially, the system uses a transient wireless network, allowing multiple locations to be explored during a field visit, and for plans to be changed dynamically if required. Central to the concept is the requirement for independent investigative learning: students are enabled to participate actively in the learning experience and to direct the investigations, as opposed to being simply remote viewers of the experience. Two ways of using the ERA system have been investigated: remote access and collaborative groupwork. In 2006 and 2008 remote

  8. Attitudinal Determinants of Local Public Health Workers' Participation in Hurricane Sandy Recovery Activities.

    PubMed

    Errett, Nicole A; Egan, Shannon; Garrity, Stephanie; Rutkow, Lainie; Walsh, Lauren; Thompson, Carol B; Strauss-Riggs, Kandra; Altman, Brian; Schor, Kenneth; Barnett, Daniel J

    2015-01-01

    Local health departments play a critical role in short-, intermediate-, and long-term recovery activities after a public health emergency. However, research has not explored attitudinal determinants of health department workers' participation in the recovery phase following a disaster. Accordingly, this qualitative investigation aims to understand perceived facilitators and barriers to performing recovery-related activities following Hurricane Sandy among local health department workers. In January 2014, 2 focus groups were conducted in geographically representative clusters of local health departments affected by Hurricane Sandy (1 cluster in Maryland and 1 cluster in New Jersey). Focus groups were recorded, transcribed verbatim, and analyzed to qualitatively assess attitudes toward Hurricane Sandy recovery activities. This analysis identified 5 major thematic categories as facilitators and barriers to participation in recovery activities: training, safety, family preparedness, policies and planning, and efficacy. Systems that support engagement of health department personnel in recovery activities may endeavor to develop and communicate intra- and interjurisdictional policies that minimize barriers in these areas. Development and implementation of evidence-informed curricular interventions that explain recovery roles may also increase local health department worker motivation to participate in recovery activities. PMID:26173013

  9. Predictors of Change Over Time in the Activity Participation of Children and Youth with Physical Disabilities

    PubMed Central

    King, Gillian; McDougall, Janette; DeWit, David; Petrenchik, Theresa; Hurley, Patricia; Law, Mary

    2009-01-01

    Little is known about predictors of change over time in the intensity of the leisure and recreational activity participation of children with physical disabilities. This study reports data from 402 children/youth with physical disabilities (216 boys and 186 girls), ages 6 to 15, collected on three occasions over a 3-year period. Latent growth curve modeling was used to determine the significant child, family, and community predictors of change in the intensity of their participation in five types of activities (recreational, active physical, social, skill-based, and self-improvement). Differences in predictors were examined for boys versus girls, and older versus younger children. Significant predictors of change were found only for recreational and active physical activities. The findings indicate that factors associated with change in participation intensity are dependent on the type of activity, and vary as a function of children’s sex and age. Implications for research and service delivery are discussed, including the importance of a contextualized, holistic, and developmental approach to intervention. PMID:19907673

  10. Attitudinal Determinants of Local Public Health Workers' Participation in Hurricane Sandy Recovery Activities.

    PubMed

    Errett, Nicole A; Egan, Shannon; Garrity, Stephanie; Rutkow, Lainie; Walsh, Lauren; Thompson, Carol B; Strauss-Riggs, Kandra; Altman, Brian; Schor, Kenneth; Barnett, Daniel J

    2015-01-01

    Local health departments play a critical role in short-, intermediate-, and long-term recovery activities after a public health emergency. However, research has not explored attitudinal determinants of health department workers' participation in the recovery phase following a disaster. Accordingly, this qualitative investigation aims to understand perceived facilitators and barriers to performing recovery-related activities following Hurricane Sandy among local health department workers. In January 2014, 2 focus groups were conducted in geographically representative clusters of local health departments affected by Hurricane Sandy (1 cluster in Maryland and 1 cluster in New Jersey). Focus groups were recorded, transcribed verbatim, and analyzed to qualitatively assess attitudes toward Hurricane Sandy recovery activities. This analysis identified 5 major thematic categories as facilitators and barriers to participation in recovery activities: training, safety, family preparedness, policies and planning, and efficacy. Systems that support engagement of health department personnel in recovery activities may endeavor to develop and communicate intra- and interjurisdictional policies that minimize barriers in these areas. Development and implementation of evidence-informed curricular interventions that explain recovery roles may also increase local health department worker motivation to participate in recovery activities.

  11. Is Participation in Organized Leisure-Time Activities Associated with School Performance in Adolescence?

    PubMed Central

    Sigmundova, Dagmar; Sirucek, Jan

    2016-01-01

    Background Organized leisure-time activities (OLTA) have been identified as a context suitable for improvement of school performance. This study aimed to assess the associations between participation in OLTA and school engagement, school-related stress, academic achievement and whether these associations differ by specific pattern of OLTA participation, gender and age. Furthermore, it assessed whether OLTA participants are more likely to acquire support for schoolwork from outside the family. Methods The sample concerned 10,483 adolescents (49.2% boys) aged 11, 13 and 15 from the Health Behaviour in School-aged Children data collection in 2014 in the Czech Republic. Logistic regressions adjusted for gender and age were used to analyse the associations between participation in OLTA and four education-related outcomes. Results Participation in OLTA was associated with higher school engagement, lower levels of school-related stress and better academic achievement regardless of gender and age. The strongest associations were observed for adolescents involved in various types of OLTA concurrently, with odds ratios ranging from 1.34 (95% confidence interval (CI) 1.17–1.54) for lower school-related stress to 1.97 (95% CI 1.73–2.25) for above-average academic achievement. OLTA participants were also more likely to have a non-familial person to help them with schoolwork, though this association was weaker in 15-year-olds. Conclusion Youth involvement in OLTA is linked to general better school performance and attachment to school. Adolescents participating in more activities at the same time have the best school performance. PMID:27073841

  12. Mexican-Origin Youth Participation in Extracurricular Activities: Predicting Trajectories of Involvement from 7th to 12th Grade.

    PubMed

    Dawes, Nickki Pearce; Modecki, Kathryn L; Gonzales, Nancy; Dumka, Larry; Millsap, Roger

    2015-11-01

    The potential benefits of participation in extracurricular activities may be especially important for youth who are at risk for academic underachievement, such as low income Mexican-origin youth in the U.S. To advance understanding of factors that drive participation for this population, this study examined Mexican-origin youth's trajectories of participation in extracurricular activities across Grades 7-12 and tested theoretically-derived predictors of these trajectories. Participants were 178 adolescents (53.9 % Female, Mage = 12.28) and their mothers who separately completed in-home interviews. Youth reported the frequency of their participation across a range of extracurricular activities. Latent growth curve models of overall extracurricular activities participation, sports participation, and fine arts participation were individually estimated via structural equation modeling. The findings demonstrated developmental declines in overall participation and in sports participation. For fine arts, declines in participation in middle school were followed by subsequent increases during high school (a curvilinear pattern). Motivationally-salient predictors of participation trajectories included youth's traditional cultural values orientation (sports), the mothers' educational aspirations for the youth (sports, fine arts, overall activity), and youth gender (sports, fine arts). Overall, the results suggest variability in participation trajectories based on program type, and highlight the need for additional research to enhance our understanding of the impact of culturally-relevant predictors on participation over time.

  13. Participation of PLA2 and PLC in DhL-induced activation of Rhinella arenarum oocytes.

    PubMed

    Zapata-Martínez, J; Medina, M F; Gramajo-Bühler, M C; Sánchez-Toranzo, G

    2016-08-01

    Rhinella arenarum oocytes can be artificially activated, a process known as parthenogenesis, by a sesquiterpenic lactone of the guaianolide group, dehydroleucodine (DhL). Transient increases in the concentration of cytosolic Ca2+ are essential to trigger egg activation events. In this sense, the 1-4-5 inositol triphosphate receptors (IP3R) seem to be involved in the Ca2+ transient release induced by DhL in this species. We analyzed the involvement of phosphoinositide metabolism, especially the participation of phospholipase A2 (PLA2) and phospholipase C (PLC) in DhL-induced activation. Different doses of quinacrine, aristolochic acid (ATA) (PLA2 inhibitors) or neomycin, an antibiotic that binds to PIP2, thus preventing its hydrolysis, were used in mature Rhinella arenarum oocytes. In order to assay the participation of PI-PLC and PC- PLC we used U73122, a competitive inhibitor of PI-PLC dependent events and D609, an inhibitor of PC-PLC. We found that PLA2 inhibits quinacrine more effectively than ATA. This difference could be explained by the fact that quinacrine is not a specific inhibitor for PLA2 while ATA is specific for this enzyme. With respect to the participation of PLC, a higher decrease in oocyte activation was detected when cells were exposed to neomycin. Inhibition of PC-PLC with D609 and IP-PLC with U73122 indicated that the last PLC has a significant participation in the effect of DhL-induced activation. Results would indicate that DhL induces activation of in vitro matured oocytes of Rhinella arenarum by activation of IP-PLC, which in turn may induce IP3 formation which produces Ca2+ release.

  14. Children with Autism Spectrum Disorder and Patterns of Participation in Daily Physical and Play Activities

    PubMed Central

    Memari, Amir Hossein; Panahi, Nekoo; Ranjbar, Elaheh; Moshayedi, Pouria; Shafiei, Masih; Kordi, Ramin; Ziaee, Vahid

    2015-01-01

    Autism spectrum disorder (ASD) indicates several neurodevelopmental impairments which may end in impairments in motor or physical activities. Daily physical activity involvement was investigated in a total of 83 children (52 boys and 31 girls) with ASD aged 6–15 years. Results indicated that only 10 (12%) of children with ASD were physically active. Children were predominantly engaged in solitary play rather than social play activities. Gender, family income, and household structure were found to be associated with activity scores. Financial burden and lack of opportunities were noted as the leading barriers to physical activities. In conclusion, findings indicated a low rate of physical activity participation in children with ASD that is closely associated with sociodemographic variables. PMID:26171247

  15. Urinary-Type Plasminogen Activator Receptor (uPA/R)/α3β1 Integrin Signaling, Altered Gene Expression, and Oral Tumor Progression

    PubMed Central

    Ghosh, Supurna; Koblinski, Jennifer; Johnson, Jeffrey; Liu, Yueying; Ericsson, Aaron; Davis, J. Wade; Shi, Zonggao; Ravosa, Matthew J.; Crawford, Susan; Frazier, Shellaine; Stack, M. Sharon

    2009-01-01

    Oral squamous cell carcinoma (OSCC) has 50% 5-year survival rate, highlighting our limited understanding of the molecular events that contribute to disease progression. Microarray analyses of primary oral tumors have identified urinary type plasminogen activator (uPA) and its receptor (uPAR) as key genes associated with human OSCC progression. The uPAR functions both as a proteinase receptor and an integrin ligand, modifying proteolysis, migration, integrin signaling and cellular transcription. In the current study, uPAR expression levels were modified in OSCC cells, followed by analysis of tumor growth in an in vivo orthotopic xenograft model and by transcriptional profiling. Overexpression of uPAR resulted in more infiltrative and less differentiated tumors, with ill-defined borders, cytologic atypia, and enhanced vascularity. Analysis of serial sections of both murine experimental tumors and microarrayed human OSCC demonstrated a statistically significant association between uPAR and α3 integrin co-localization in areas exhibiting ERK phosphorylation, suggesting that uPAR/α3 integrin interaction potentiates ERK signaling in vivo. This is supported by cDNA microarray analysis which showed differential expression of 148 genes (113 up, 35 down). Validation of gene expression changes in human OSCC using immunohistochemistry and quantitative real-time PCR showed increased growth factors, proteinases/inhibitor and matrix components in uPAR-overexpressing tumors. Together these results support a model wherein increased uPAR expression promotes α3β1 integrin association, resulting in increased MAPK signaling and transcriptional activation, leading to the formation of more aggressive tongue tumors. This combined approach has efficacy to identify additional biomarkers and/or prognostic indicators associated with aggressive human OSCC. PMID:20145038

  16. Extracurricular activity availability and participation and substance use among American Indian adolescents.

    PubMed

    Moilanen, Kristin L; Markstrom, Carol A; Jones, Elizabeth

    2014-03-01

    School-based extracurricular activity involvement has been associated with lower levels of substance use among adolescents from various populations; however, these associations have only been slightly examined among American Indian (AI) adolescents. Building from various theoretical perspectives, it was hypothesized that AI adolescents' perceived access to and the intensity (i.e., frequency) of participation in extracurricular activities would be associated with lower substance use and less engagement in risky substance use behaviors (i.e., being drunk or high at school, riding/driving with an intoxicated driver, and selling drugs). The moderating influences of sex, age, reservation residence, and metropolitan status also were examined. Data from the 2010 Arizona Youth Survey were analyzed for 5,701 8th, 10th, and 12th grade AI adolescents (49.1% female). The expected protective effects of extracurricular participation were demonstrated, such that high levels of perceived availability and intensity of participation consistently predicted low levels of all outcomes. Some of these associations were moderated by one or more demographic factors, with unique patterns emerging for each behavior. Ultimately, the findings suggest that AI adolescents benefit from the availability of extracurricular activities and intensity of participation in them, but the degree of the effect is contingent upon other individual and contextual characteristics.

  17. Effects of sports participation on psychiatric symptoms and brain activations during sports observation in schizophrenia

    PubMed Central

    Takahashi, H; Sassa, T; Shibuya, T; Kato, M; Koeda, M; Murai, T; Matsuura, M; Asai, K; Suhara, T; Okubo, Y

    2012-01-01

    Weight gain has been identified as being responsible for increased morbidity and mortality rates of schizophrenia patients. For the management of weight gain, exercise is one of the most acknowledged interventions. At the same time, exercise and sports have been recognized for their positive impact on psychiatric symptoms of schizophrenia. However, the neurobiological basis for this remains poorly understood. We aimed to examine the effect of sports participation on weight gain, psychiatric symptoms and brain activation during sports observation in schizophrenia patients. Thirteen schizophrenia patients who participated in a 3-month program, including sports participation and 10 control schizophrenia patients were studied. In both groups, body mass index (BMI), Positive and Negative Syndrome Scale (PANSS), and brain activation during observation of sports-related actions measured by functional magnetic resonance imaging were accessed before and after a 3-month interval. BMI and general psychopathology scale of PANSS were significantly reduced in the program group but not in the control group after a 3-month interval. Compared with baseline, activation of the body-selective extrastriate body area (EBA) in the posterior temporal-occipital cortex during observation of sports-related actions was increased in the program group. In this group, increase in EBA activation was associated with improvement in the general psychopathology scale of PANSS. Sports participation had a positive effect not only on weight gain but also on psychiatric symptoms in schizophrenia. EBA might mediate these beneficial effects of sports participation. Our findings merit further investigation of neurobiological mechanisms underlying the therapeutic effect of sports for schizophrenia. PMID:22832861

  18. Effects of sports participation on psychiatric symptoms and brain activations during sports observation in schizophrenia.

    PubMed

    Takahashi, H; Sassa, T; Shibuya, T; Kato, M; Koeda, M; Murai, T; Matsuura, M; Asai, K; Suhara, T; Okubo, Y

    2012-01-01

    Weight gain has been identified as being responsible for increased morbidity and mortality rates of schizophrenia patients. For the management of weight gain, exercise is one of the most acknowledged interventions. At the same time, exercise and sports have been recognized for their positive impact on psychiatric symptoms of schizophrenia. However, the neurobiological basis for this remains poorly understood. We aimed to examine the effect of sports participation on weight gain, psychiatric symptoms and brain activation during sports observation in schizophrenia patients. Thirteen schizophrenia patients who participated in a 3-month program, including sports participation and 10 control schizophrenia patients were studied. In both groups, body mass index (BMI), Positive and Negative Syndrome Scale (PANSS), and brain activation during observation of sports-related actions measured by functional magnetic resonance imaging were accessed before and after a 3-month interval. BMI and general psychopathology scale of PANSS were significantly reduced in the program group but not in the control group after a 3-month interval. Compared with baseline, activation of the body-selective extrastriate body area (EBA) in the posterior temporal-occipital cortex during observation of sports-related actions was increased in the program group. In this group, increase in EBA activation was associated with improvement in the general psychopathology scale of PANSS. Sports participation had a positive effect not only on weight gain but also on psychiatric symptoms in schizophrenia. EBA might mediate these beneficial effects of sports participation. Our findings merit further investigation of neurobiological mechanisms underlying the therapeutic effect of sports for schizophrenia.

  19. Participatory action research: practical strategies for actively engaging and maintaining participation in immigrant and refugee communities.

    PubMed

    van der Velde, Jeannette; Williamson, Deanna L; Ogilvie, Linda D

    2009-09-01

    In this research we examined the processes involved in implementing and maintaining a participatory action research (PAR) project by uncovering how theoretical PAR tenets hold up in the reality of a community-based project addressing immigrants' and refugees' mental health needs. Qualitative data from focus groups with these newcomers were analyzed for thematic content. Findings reveal that active participation is seen as the gateway into a PAR project, whereas knowledge attainment and empowerment are the stimuli for continued participation. The data also suggest that newcomers' motivations to participate in a PAR-oriented project might vary across ethno-cultural groups. Practitioners working in community-based initiatives would do well to appeal to the diversity of motivational factors, while endorsing individual and group strengths.

  20. Functional Characterization of Phalaenopsis aphrodite Flowering Genes PaFT1 and PaFD.

    PubMed

    Jang, Seonghoe; Choi, Sang-Chul; Li, Hsing-Yi; An, Gynheung; Schmelzer, Elmon

    2015-01-01

    We show that the key flowering regulators encoded by Phalaenopsis aphrodite FLOWERING LOCUS T1 (PaFT1) and PaFD share high sequence homologies to these from long-day flowering Arabidopsis and short-day flowering rice. Interestingly, PaFT1 is specifically up-regulated during flowering inductive cooling treatment but is not subjected to control by photoperiod in P. aphrodite. Phloem or shoot apex-specific expression of PaFT1 restores the late flowering of Arabidopsis ft mutants. Moreover, PaFT1 can suppress the delayed flowering caused by SHORT VEGATATIVE PHASE (SVP) overexpression as well as an active FRIGIDA (FRI) allele, indicating the functional conservation of flowering regulatory circuit in different plant species. PaFT1 promoter:GUS in Arabidopsis showed similar staining pattern to that of Arabidopsis FT in the leaves and guard cells but different in the shoot apex. A genomic clone or heat shock-inducible expression of PaFT1 is sufficient to the partial complementation of the ft mutants. Remarkably, ectopic PaFT1 expression also triggers precocious heading in rice. To further demonstrate the functional conservation of the flowering regulators, we show that PaFD, a bZIP transcription factor involved in flowering promotion, interacts with PaFT1, and PaFD partially complemented Arabidopsis fd mutants. Transgenic rice expressing PaFD also flowered early with increased expression of rice homologues of APETALA1 (AP1). Consistently, PaFT1 knock-down Phalaenopsis plants generated by virus-induced gene silencing exhibit delayed spiking. These studies suggest functional conservation of FT and FD genes, which may have evolved and integrated into distinct regulatory circuits in monopodial orchids, Arabidopsis and rice that promote flowering under their own inductive conditions. PMID:26317412

  1. Functional Characterization of Phalaenopsis aphrodite Flowering Genes PaFT1 and PaFD

    PubMed Central

    Jang, Seonghoe; Choi, Sang-Chul; Li, Hsing-Yi; An, Gynheung; Schmelzer, Elmon

    2015-01-01

    We show that the key flowering regulators encoded by Phalaenopsis aphrodite FLOWERING LOCUS T1 (PaFT1) and PaFD share high sequence homologies to these from long-day flowering Arabidopsis and short-day flowering rice. Interestingly, PaFT1 is specifically up-regulated during flowering inductive cooling treatment but is not subjected to control by photoperiod in P. aphrodite. Phloem or shoot apex-specific expression of PaFT1 restores the late flowering of Arabidopsis ft mutants. Moreover, PaFT1 can suppress the delayed flowering caused by SHORT VEGATATIVE PHASE (SVP) overexpression as well as an active FRIGIDA (FRI) allele, indicating the functional conservation of flowering regulatory circuit in different plant species. PaFT1 promoter:GUS in Arabidopsis showed similar staining pattern to that of Arabidopsis FT in the leaves and guard cells but different in the shoot apex. A genomic clone or heat shock-inducible expression of PaFT1 is sufficient to the partial complementation of the ft mutants. Remarkably, ectopic PaFT1 expression also triggers precocious heading in rice. To further demonstrate the functional conservation of the flowering regulators, we show that PaFD, a bZIP transcription factor involved in flowering promotion, interacts with PaFT1, and PaFD partially complemented Arabidopsis fd mutants. Transgenic rice expressing PaFD also flowered early with increased expression of rice homologues of APETALA1 (AP1). Consistently, PaFT1 knock-down Phalaenopsis plants generated by virus-induced gene silencing exhibit delayed spiking. These studies suggest functional conservation of FT and FD genes, which may have evolved and integrated into distinct regulatory circuits in monopodial orchids, Arabidopsis and rice that promote flowering under their own inductive conditions. PMID:26317412

  2. Performance Measures for Evaluating Public Participation Activities in the Office of Environmental Management (DOE)

    SciTech Connect

    Carnes, S.A.

    2001-02-15

    Public participation in Office of Environmental Management (EM) activities throughout the DOE complex is a critical component of the overall success of remediation and waste management efforts. The challenges facing EM and its stakeholders over the next decade or more are daunting (Nuclear Waste News 1996). Achieving a mission composed of such challenges will require innovation, dedication, and a significant degree of good will among all stakeholders. EM's efforts to date, including obtaining and using inputs offered by EM stakeholders, have been notable. Public participation specialists have accepted and met challenges and have consistently tried to improve their performance. They have reported their experiences both formally and informally (e.g., at professional conferences and EM Public Participation Network Workshops, other internal meetings of DOE and contractor public participation specialists, and one-on-one consultations) in order to advance the state of their practice. Our research, and our field research in particular (including our interactions with many representatives of numerous stakeholder groups at nine DOE sites with diverse EM problems), have shown that it, is possible to develop coherent results even in a problem domain as complex as that of EM. We conclude that performance-based evaluations of public participation appear possible, and we have recommended an approach, based on combined and integrated multi-stakeholder views on the attributes of successful public participation and associated performance indicators, that seems workable and should be acceptable to diverse stakeholders. Of course, as an untested recommendation, our approach needs the validation that can only be achieved by application (perhaps at a few DOE sites with ongoing EM activities). Such an application would serve to refine the proposed approach in terms of its clarity, its workability, and its potential for full-scale use by EM and, potentially, other government agencies and

  3. Association Between Social Participation and Instrumental Activities of Daily Living Among Community-Dwelling Older Adults

    PubMed Central

    Tomioka, Kimiko; Kurumatani, Norio; Hosoi, Hiroshi

    2016-01-01

    Background Population-based data examining the relationship between social participation (SP) and instrumental activities of daily living (IADL) are scarce. This study examined the cross-sectional relationship between SP and IADL in community-dwelling elderly persons. Methods Self-administered questionnaires were mailed to 23 710 residents aged ≥65 years in Nara, Japan (response rate: 74.2%). Data from 14 956 respondents (6935 males and 8021 females) without dependency in basic activities of daily living (ADL) were analyzed. The number, type, and frequency of participation in social groups (SGs) were used to measure SP. SGs included volunteer groups, sports groups, hobby groups, senior citizens’ clubs, neighborhood community associations, and cultural groups. IADL was evaluated using the Tokyo Metropolitan Institute of Gerontology Index of Competence. Logistic regression models stratified by gender were used. Results After adjustment for putative confounding factors, including demographics, health status, life-style habits, ADL, depression, cognitive function, social networks, social support, and social roles, participation in various SGs among both genders was inversely associated with poor IADL, showing a significant dose-response relationship between an increasing number of SGs and a lower proportion of those with poor IADL (P for trend <0.001). A significant inverse association between frequent participation and poor IADL was observed for all types of SGs among females, whereas the association was limited to sports groups and senior citizens’ clubs among males. Conclusions Our results show that participation in a variety of SGs is associated with independent IADL among the community-dwelling elderly, regardless of gender. However, the beneficial effects of frequent participation on IADL may be stronger for females than for males. PMID:27180933

  4. Brief report: Performing on the stage, the field, or both? Australian adolescent extracurricular activity participation and self-concept.

    PubMed

    Blomfield, Corey J; Barber, Bonnie L

    2009-06-01

    The relationship between Australian adolescents' participation in extracurricular activities and their self-concepts was investigated. A total of 1489 adolescents (56% female; mean age 13.8 years) completed measures of social self-concept, academic self-concept, and general self-worth, and reported on their extracurricular activity participation. In general, participation in any type of extracurricular activity was associated with a higher social and academic self-concept, and general self-worth, compared to no participation. Adolescents who participated in both sports and non-sports also reported a more positive social self-concept and general self-worth, compared to those who only participated in one of the activity types. This research provides support for extracurricular activities as a context facilitative of positive self-concept, and demonstrates the importance of a mixed participation profile for an adolescent's self-concept.

  5. Barriers to participation in physical activity and exercise among middle-aged and elderly individuals.

    PubMed

    Justine, Maria; Azizan, Azliyana; Hassan, Vaharli; Salleh, Zoolfaiz; Manaf, Haidzir

    2013-10-01

    INTRODUCTION Although the benefits of physical activity and exercise are widely acknowledged, many middle-aged and elderly individuals remain sedentary. This cross-sectional study aimed to identify the external and internal barriers to physical activity and exercise participation among middle-aged and elderly individuals, as well as identify any differences in these barriers between the two groups. METHODS Recruited individuals were categorised into either the middle-aged (age 45-59 years, n = 60) or elderly (age ≥ 60 years, n = 60) group. Data on demographics, anthropometry, as well as external and internal barriers to participation in physical activity and exercise were collected. RESULTS Analysis showed no significant differences in the total scores of all internal barriers between the two groups (p > 0.05). The total scores for most external barriers between the two groups also showed no significant differences (p > 0.05); only 'cost' (p = 0.045) and 'exercise interferes with social/family activities' (p = 0.011) showed significant differences. The most common external barriers among the middle-aged and elderly respondents were 'not enough time' (46.7% vs. 48.4%), 'no one to exercise with' (40.0% vs. 28.3%) and 'lack of facilities' (33.4% vs. 35.0%). The most common internal barriers for middle-aged respondents were 'too tired' (48.3%), 'already active enough' (38.3%), 'do not know how to do it' (36.7%) and 'too lazy' (36.7%), while those for elderly respondents were 'too tired' (51.7%), 'lack of motivation' (38.4%) and 'already active enough' (38.4%). CONCLUSION Middle-aged and elderly respondents presented with similar external and internal barriers to physical activity and exercise participation. These factors should be taken into account when healthcare policies are being designed and when interventions such as the provision of facilities to promote physical activity and exercise among older people are being considered.

  6. [Pre-participation screening of individuals engaging in noncompetitive physical activity].

    PubMed

    Scheinowitz, Mickey; Dankner, Rachel; Goldbourt, Uri; Marom-Klibansky, Rachel

    2008-07-01

    There is accumulating data suggesting that physical activity is associated with reduced total mortality, sudden cardiac death, reduced risk of cardiovascular diseases, colon and breast cancer, osteoporosis, diabetes, hypertension, obesity, cognitive decline, dementia and depression. In addition, physical activity increases work productivity and well-being. Despite these health benefits, only approximately 30% of Israelis engage in regular physical activity. In Israel, the Physical Fitness Law requires a medical clearance prior to participation in physical activity in the gym. However, the medical community does not have written recommendations as to what type of examinations one should undergo. This paper was written following a request by the National Committee for the Prevention and Treatment of Cardiovascular Diseases, Israeli Ministry of Health, joined by the Israeli Heart Society to write new recommendations for the primary health care physician on the medical screening needed prior to the participation in a non-competitive physical activity among healthy Israelis. It includes a self report physical activity readiness questionnaire (PAR-Q), medical examinations, and exercise stress test. Since moderate types of physical activity performed under supervised conditions in a health/fitness facilities are safe, the recommendations for most individuals would be to complete the PAR-Q questionnaire with no further medical examinations. The position of the authors in the current article is similar to that approved by the National Committee for the Prevention and Treatment of Cardiovascular Diseases and the Israeli Heart Society and as was published by the Israel Medical Association.

  7. Physical Activity, Physical Fitness, and Health-Related Quality of Life in School-Aged Children

    ERIC Educational Resources Information Center

    Gu, Xiangli; Chang, Mei; Solmon, Melinda A.

    2015-01-01

    Purpose: This study examined the association between physical activity (PA), physical fitness, and health-related quality of life (HRQOL) among school-aged children. Methods: Participants were 201 children (91 boys, 110 girls; M[subscript age] = 9.82) enrolled in one school in the southern US. Students' PA (self-reported PA, pedometer-based PA)…

  8. Focused campaign increases activity among participants in Nature's Notebook, a citizen science project

    USGS Publications Warehouse

    Crimmins, Theresa M.; Weltzin, Jake F.; Rosemartin, Alyssa H.; Surina, Echo M.; Marsh, Lee; Denny, Ellen G.

    2014-01-01

    Citizen science projects, which engage non-professional scientists in one or more stages of scientific research, have been gaining popularity; yet maintaining participants’ activity level over time remains a challenge. The objective of this study was to evaluate the potential for a short-term, focused campaign to increase participant activity in a national-scale citizen science program. The campaign that we implemented was designed to answer a compelling scientific question. We invited participants in the phenology-observing program, Nature’s Notebook, to track trees throughout the spring of 2012, to ascertain whether the season arrived as early as the anomalous spring of 2010. Consisting of a series of six electronic newsletters and costing our office slightly more than 1 week of staff resources, our effort was successful; compared with previous years, the number of observations collected in the region where the campaign was run increased by 184%, the number of participants submitting observations increased by 116%, and the number of trees registered increased by 110%. In comparison, these respective metrics grew by 25, 55, and 44%, over previous years, in the southeastern quadrant of the United States, where no such campaign was carried out. The campaign approach we describe here is a model that could be adapted by a wide variety of programs to increase engagement and thereby positively influence participant retention.

  9. An interactional structure of medical activities during acute visits and its implications for patients' participation.

    PubMed

    Robinson, Jeffrey D

    2003-01-01

    Within the context of primary-care, physician-patient visits, researchers have documented both patients' low levels of communicative participation (e.g., question asking) and the advantages of such participation to healthcare (e.g., improved physical health and satisfaction). Prior research has offered a variety of partial, non-exclusive explanations for patients' low levels of participation. This article investigates one underdeveloped source of explanation: the organization of interaction itself. This article argues that the establishment of new medical problems in acute visits makes relevant an organized structure of social action that is composed of an ordered series of medical activities: establishing the reason for the visit, physicians gathering additional information (i.e., history taking and physical examination), physicians delivering diagnoses, and physicians providing treatment recommendations. This "project" of medical activity shapes physicians' and patients' understanding and production of communicative behavior. Using the method of conversation analysis, and analyzing transcribed audio- and videotape data of actual acute visits, this article describes and grounds this project and discusses its implications for research, theory, and improvement on patient participation.

  10. Katimavik Participant's Manual, Book VII, Socio-Cultural Activities = Katimavik manuel du participant, cahier VII, activites socio-culturelles.

    ERIC Educational Resources Information Center

    OPCAN, Montreal (Quebec).

    The bilingual student manual, devoted to the socio-cultural learning activity portion of Katimavik (a nine-month volunteer community service and experiential learning program for 17 to 21 year old Canadians), contains sections on learning program objectives and trimester guidelines, optional activities, resume recordkeeping, general topic…

  11. Characteristics of "Tween" Participants and Non-Participants in the VERB[TM] Summer Scorecard Physical Activity Promotion Program

    ERIC Educational Resources Information Center

    Nickelson, Jen; Alfonso, Moya L.; McDermott, Robert J.; Bumpus, Elizabeth C.; Bryant, Carol A.; Baldwin, Julie A.

    2011-01-01

    Creating community-based opportunities for youth to be physically active is challenging for many municipalities. A Lexington, Kentucky community coalition designed and piloted a physical activity program, "VERB[TM] summer scorecard (VSS)", leveraging the brand equity of the national VERB[TM]--It's What You Do! campaign. Key elements of VSS…

  12. Obesity and other correlates of physical activity and sedentary behaviors among US high school students.

    PubMed

    Lowry, Richard; Lee, Sarah M; Fulton, Janet E; Demissie, Zewditu; Kann, Laura

    2013-01-01

    Understanding correlates of physical activity (PA) can help inform and improve programs that promote PA among youth. We analyzed data from the 2010 National Youth Physical Activity and Nutrition Study, a representative sample of US students in grades 9-12. Logistic regression was used to examine associations between PA correlates (obesity, physical education classes, sports team participation, attitude toward PA, adult support for PA, and environmental support for PA) and participation in daily PA (DPA), vigorous PA (VPA), muscle-strengthening activity (MSA), viewing television (TV), and using computers or video games (C/VG). A positive attitude toward PA and adult support for PA were both associated with increased PA and decreased sedentary behavior. However, among students who lived in neighborhoods that were not safe for PA, a positive attitude toward PA was not associated with increased DPA or decreased sedentary behavior and was less strongly associated with VPA and MSA. Efforts to increase PA among youth should promote a positive attitude toward PA among youth and encourage adult family members to support their efforts to be active. Policies that promote safe neighborhoods may work synergistically with a positive attitude toward PA to increase participation in PA and decrease sedentary behaviors.

  13. Obesity and other correlates of physical activity and sedentary behaviors among US high school students.

    PubMed

    Lowry, Richard; Lee, Sarah M; Fulton, Janet E; Demissie, Zewditu; Kann, Laura

    2013-01-01

    Understanding correlates of physical activity (PA) can help inform and improve programs that promote PA among youth. We analyzed data from the 2010 National Youth Physical Activity and Nutrition Study, a representative sample of US students in grades 9-12. Logistic regression was used to examine associations between PA correlates (obesity, physical education classes, sports team participation, attitude toward PA, adult support for PA, and environmental support for PA) and participation in daily PA (DPA), vigorous PA (VPA), muscle-strengthening activity (MSA), viewing television (TV), and using computers or video games (C/VG). A positive attitude toward PA and adult support for PA were both associated with increased PA and decreased sedentary behavior. However, among students who lived in neighborhoods that were not safe for PA, a positive attitude toward PA was not associated with increased DPA or decreased sedentary behavior and was less strongly associated with VPA and MSA. Efforts to increase PA among youth should promote a positive attitude toward PA among youth and encourage adult family members to support their efforts to be active. Policies that promote safe neighborhoods may work synergistically with a positive attitude toward PA to increase participation in PA and decrease sedentary behaviors. PMID:23606950

  14. Activation properties of trigeminal motoneurons in participants with and without bruxism

    PubMed Central

    D'Amico, Jessica M.; Yavuz, Ş. Utku; Saraçoğlu, Ahmet; Atiş, Elif Sibel; Türker, Kemal S.

    2013-01-01

    In animals, sodium- and calcium-mediated persistent inward currents (PICs), which produce long-lasting periods of depolarization under conditions of low synaptic drive, can be activated in trigeminal motoneurons following the application of the monoamine serotonin. Here we examined if PICs are activated in human trigeminal motoneurons during voluntary contractions and under physiological levels of monoaminergic drive (e.g., serotonin and norepinephrine) using a paired motor unit analysis technique. We also examined if PICs activated during voluntary contractions are larger in participants who demonstrate involuntary chewing during sleep (bruxism), which is accompanied by periods of high monoaminergic drive. In control participants, during a slowly increasing and then decreasing isometric contraction, the firing rate of an earlier-recruited masseter motor unit, which served as a measure of synaptic input to a later-recruited test unit, was consistently lower during derecruitment of the test unit compared with at recruitment (ΔF = 4.6 ± 1.5 imp/s). The ΔF, therefore, is a measure of the reduction in synaptic input needed to counteract the depolarization from the PIC to provide an indirect estimate of PIC amplitude. The range of ΔF values measured in the bruxer participants during similar voluntary contractions was the same as in controls, suggesting that abnormally high levels of monoaminergic drive are not continually present in the absence of involuntary motor activity. We also observed a consistent “onion skin effect” during the moderately sized contractions (<20% of maximal), whereby the firing rate of higher threshold motor units discharged at slower rates (by 4–7 imp/s) compared with motor units with relatively lower thresholds. The presence of lower firing rates in the more fatigue-prone, higher threshold trigeminal motoneurons, in addition to the activation of PICs, likely facilitates the activation of the masseter muscle during motor activities

  15. Performance measures for evaluating public participation activities in DOE`s Office of Environmental Management

    SciTech Connect

    Carnes, S.A.; Schweitzer, M.; Peelle, E.B.; Wolfe, A.K.; Munro, J.F.

    1996-08-01

    Public participation in decision-making in the United States has become a dominant theme throughout the public sector and is increasingly used in the private sector. Recent reports by the National Research Council and the Commission on Risk Assessment and Risk Management, set up jointly by the White House and Congress, conclude that risk decisions must increasingly be structured in such a manner as to involve stakeholders meaningfully in the processes and activities leading to decisions and, perhaps, through decision implementation. Both of these reports indicate that decisions may take longer but be better if officials: (1) bring all interested and affected parties to the table at the beginning of the risk-discussion process; (2) identify relevant concerns, losses, exposures and other information the parties have; (3) address significant concerns through appropriate research; and (4) present findings in an understandable, accessible way. This report is intended to facilitate subsequent evaluations of public participation activities and programs.

  16. [Participation of the primary motor cortex in programming of muscle activity during catching of falling object].

    PubMed

    Kazennikov, O V; Lipshits, M I

    2011-01-01

    Object fell into the cup that sitting subject held between thumb and index fingers. Transcranial magnetic stimulation (TMS) of the primary motor cortex was performed early before and during anticipatory grip force increasing. Comparison of current EMG activity of adductor pollicis brevis and first dorsal interosseous muscles and responses of these muscles on TMS showed that responses were increased before the raising of muscle activity. From the other side only slight augmentation of responses was observed during subsequent strong muscle activation. It is assumed that the increasing of the TMS responses that occurred before the initiation of muscle activity reflects the enhancement ofthe motor cortex excitability associated to specific processes related to the motor cortex participation in programming of the muscles activities. PMID:22117465

  17. Perspectives and experiences related to physical activity of elders in long-term-care settings.

    PubMed

    Phillips, Lorraine J; Flesner, Marcia

    2013-01-01

    This qualitative study investigated individual and situational factors influencing physical activity (PA) practices of elders in residential-care/assisted-living (RC/AL) communities. This article describes the results of focus-group interviews involving 47 residents across 6 RC/AL settings. Thematic analysis revealed 6 themes: staying active, past PA experiences, value of PA, barriers to PA, strategies to facilitate PA, and support needs to promote PA. Staying active meant walking indoors and out, attending chair-exercise programs, performing professionally prescribed home exercises, and using available exercise equipment. Past PA experiences shaped current preferences and practices. Participants agreed that exercise helped maintain physical functioning but recounted cognitive and situational barriers to PA. Lack of dedicated exercise space and short corridors hampered efforts to stay active. Participants wished for individualized home exercise programs and supervised exercise sessions. Future research should examine the extent to which the physical environment and PA programming in RC/AL communities affect elders' PA.

  18. Expanding nurses' participation in ethics: an empirical examination of ethical activism and ethical assertiveness.

    PubMed

    Dodd, Sarah-Jane; Jansson, Bruce S; Brown-Saltzman, Katherine; Shirk, Marilyn; Wunch, Karen

    2004-01-01

    This research project investigated the extent to which nurses engage in two important kinds of ethical behaviours: ethical activism (where they try to make hospitals more receptive to nurses' participation in ethics deliberations) and ethical assertiveness (where they participate in ethics deliberations even when not formally invited). This research probed not only the extent to which nurses engage in these ethical behaviours but also whether this is influenced by professional, training and organizational factors. A random sample of 165 nurses from three major hospitals in Los Angeles provided the data. Regression analyses indicate that both ethical activism and ethical assertiveness are strongly influenced by nurses' perceptions of the receptivity of hospitals to their inclusion in ethics deliberations. In addition, nurses' education in ethics is a significant predictor of ethical activism. The findings have important implications for the content of nurses' ethics training as well as for expanding the boundaries of nurses' participation in ethics deliberations. The authors define ethics deliberations as specific meetings of a number of people to discuss an ethical issue, such as one regarding the care of a patient. PMID:14763647

  19. Quantifying patterns of brain activity: Distinguishing unaffected siblings from participants with ADHD and healthy individuals.

    PubMed

    Wolfers, Thomas; van Rooij, Daan; Oosterlaan, Jaap; Heslenfeld, Dirk; Hartman, Catharina A; Hoekstra, Pieter J; Beckmann, Christian F; Franke, Barbara; Buitelaar, Jan K; Marquand, Andre F

    2016-01-01

    Attention-deficit/hyperactivity disorder (ADHD) is one of the most prevalent and heritable psychiatric disorders. While previous studies have focussed on mapping focal or connectivity differences at the group level, the present study employed pattern recognition to quantify group separation between unaffected siblings, participants with ADHD, and healthy controls on the basis of spatially distributed brain activations. This was achieved using an fMRI-adapted version of the Stop-Signal Task in a sample of 103 unaffected siblings, 184 participants with ADHD, and 128 healthy controls. We used activation maps derived from three task regressors as features in our analyses employing a Gaussian process classifier. We showed that unaffected siblings could be distinguished from participants with ADHD (area under the receiver operating characteristic curve (AUC) = 0.65, p = 0.002, 95% Modified Wald CI: 0.59-0.71 AUC) and healthy controls (AUC = 0.59, p = 0.030, 95% Modified Wald CI: 0.52-0.66 AUC), although the latter did not survive correction for multiple comparisons. Further, participants with ADHD could be distinguished from healthy controls (AUC = 0.64, p = 0.001, 95% Modified Wald CI: 0.58-0.70 AUC). Altogether the present results characterise a pattern of frontolateral, superior temporal and inferior parietal expansion that is associated with risk for ADHD. Unaffected siblings show differences primarily in frontolateral regions. This provides evidence for a neural profile shared between participants with ADHD and their healthy siblings. PMID:27489770

  20. Participating in politics resembles physical activity: general action patterns in international archives, United States archives, and experiments.

    PubMed

    Noguchi, Kenji; Handley, Ian M; Albarracín, Dolores

    2011-02-01

    A series of studies examined whether political participation can emerge from general patterns of indiscriminate activity. In the first two studies, general action tendencies were measured by combining national and state-level indicators of high activity (e.g., impulsiveness, pace of life, and physical activity) from international and U.S. data. This action-tendency index positively correlated with a measure of political participation that consisted of voting behaviors and participation in political demonstrations. The following two experimental studies indicated that participants exposed to action words (e.g., go, move) had stronger intentions to vote in an upcoming election and volunteered more time to make phone calls on behalf of a university policy than participants exposed to inaction words did (e.g., relax, stop). These studies suggest that political participation can be predicted from general tendencies toward activity present at the national and state levels, as well as from verbal prompts suggestive of activity. PMID:21177515

  1. Participating in Politics Resembles Physical Activity: General Action Patterns in International Archives, United States Archives, and Experiments

    PubMed Central

    Noguchi, Kenji; Handley, Ian M.; Albarracín, Dolores

    2016-01-01

    A series of studies examined whether political participation can emerge from general patterns of indiscriminate activity. In the first two studies, general action tendencies were measured by combining national and state-level indicators of high activity (e.g., impulsiveness, pace of life, and physical activity) from international and U.S. data. This action-tendency index positively correlated with a measure of political participation that consisted of voting behaviors and participation in political demonstrations. The following two experimental studies indicated that participants exposed to action words (e.g., go, move) had stronger intentions to vote in an upcoming election and volunteered more time to make phone calls on behalf of a university policy than participants exposed to inaction words did (e.g., relax, stop). These studies suggest that political participation can be predicted from general tendencies toward activity present at the national and state levels, as well as from verbal prompts suggestive of activity. PMID:21177515

  2. Changes in Psychosocial Factors and Physical Activity Frequency among Third- to Eighth-Grade Girls Who Participated in a Developmentally Focused Youth Sport Program: A Preliminary Study

    ERIC Educational Resources Information Center

    Debate, Rita D.; Gabriel, Kelley Pettee; Zwald, Marissa; Huberty, Jennifer; Zhang, Yan

    2009-01-01

    Background: Despite the numerous physiological, psychological, and academic benefits of physical activity (PA), declines in PA levels among girls have been observed over the last decade. The purpose of this preliminary study was to assess the short-term changes pertaining to Girls on the Run and Girls on Track developmentally focused youth sport…

  3. Physical activity and sport participation: A systematic review of the impact of fatherhood.

    PubMed

    Pot, Niek; Keizer, Renske

    2016-12-01

    Moderate to Vigorous Physical Activity (MVPA), including sport participation, is an important component of a healthy lifestyle. Scholars have devoted considerable attention to understanding the impact of parenthood on MVPA, albeit only for women. As the impact of fatherhood on men's lives is drawing more and more scholarly and societal attention, the aim of the current article is to provide an systematic overview of studies examining the impact of fatherhood on MVPA. A systematic review was conducted in Google Scholar, Web of Science and Web of Knowledge, using (combinations of) the search terms: father(hood), parent(hood), exercise, physical activity, sport and leisure time. This resulted in 54 papers reporting differences in MVPA and/or sport between fathers and childless men or within men that became father, of which 13 were included. Our overview of findings suggested that fathers spent less time on MVPA compared with childless men, but that fathers did not differ from their childless counterparts on the subarea of sport participation. Differences in time spent on MVPA were strongest between childless men and fathers with young children (< 6 yrs). Our systematic review revealed that fathers spent less time on MVPA compared to childless men, especially when they had young children. Interestingly, linkages between parental status and the subarea of sport participation were not found, which suggests that fathers cut back on other areas of MVPA. Given the impact of MVPA on a healthy lifestyle, future research in this field is warranted.

  4. Reliability and validity of the modified child and adolescent physical activity and nutrition survey (CAPANS-C) questionnaire examining potential correlates of physical activity participation among Chinese-Australian youth

    PubMed Central

    2014-01-01

    Background To date, few questionnaires examining psychosocial influences of physical activity (PA) participation have been psychometrically tested among Culturally and Linguistically Diverse (CALD) youth. An understanding of these influences may help explain the observed differences in PA among CALD youth. Therefore, this study examined the reliability and predictive validity of a brief self-report questionnaire examining potential psychological and social correlates of physical activity among a sample of Chinese-Australian youth. Methods Two Chinese-weekend cultural schools from eastern metropolitan Melbourne consented to participate in this study. In total, 505 students aged 11 to 16 years were eligible for inclusion in the present study, and of these, 106 students agreed to participate (21% response rate). Participants completed at 37-item self-report questionnaire examining perceived psychological and social influences on physical activity participation twice, with a test–retest interval of 7 days. Predictive validity, internal consistency and test–retest reliability were evaluated using exploratory factor analyses, Cronbach’s α coefficient, and the intraclass correlation coefficient (ICC) respectively. Predictive validity was assessed by correlating responses against duration spent in self-reported moderate-to-vigorous physical activity (MVPA). Results The exploratory factor analysis revealed a nine factor structure, with the majority of factors exhibiting high internal consistency (α ≥ 0.6). In addition, four of the nine factors had an ICC ≥ 0.6. Spearman rank-order correlations coefficients between the nine factors and self-reported minutes spent in MVPA ranged from -0.5 to 0.3 for all participants. Conclusion This is the first study to examine the psychometric properties of a potential psychological and social correlates questionnaire among Chinese-Australian youth. The questionnaire was found to provide reliable estimates on a range

  5. Muscle-Activation Onset Times With Shoes and Foot Orthoses in Participants With Chronic Ankle Instability

    PubMed Central

    Dingenen, Bart; Peeraer, Louis; Deschamps, Kevin; Fieuws, Steffen; Janssens, Luc; Staes, Filip

    2015-01-01

    Context Participants with chronic ankle instability (CAI) use an altered neuromuscular strategy to shift weight from double-legged to single-legged stance. Shoes and foot orthoses may influence these muscle-activation patterns. Objective To evaluate the influence of shoes and foot orthoses on onset times of lower extremity muscle activity in participants with CAI during the transition from double-legged to single-legged stance. Design Cross-sectional study. Setting Musculoskeletal laboratory. Patients or Other Participants A total of 15 people (9 men, 6 women; age = 21.8 ± 3.0 years, height = 177.7 ± 9.6 cm, mass = 72.0 ± 14.6 kg) who had CAI and wore foot orthoses were recruited. Intervention(s) A transition task from double-legged to single-legged stance was performed with eyes open and with eyes closed. Both limbs were tested in 4 experimental conditions: (1) barefoot (BF), (2) shoes only, (3) shoes with standard foot orthoses, and (4) shoes with custom foot orthoses (SCFO). Main Outcome Measure(s) The onset of activity of 9 lower extremity muscles was recorded using surface electromyography and a single force plate. Results Based on a full-factorial (condition, region, limb, vision) linear model for repeated measures, we found a condition effect (F3,91.8 = 9.39, P < .001). Differences among experimental conditions did not depend on limb or vision condition. Based on a 2-way (condition, muscle) linear model within each region (ankle, knee, hip), earlier muscle-activation onset times were observed in the SCFO than in the BF condition for the peroneus longus (P < .001), tibialis anterior (P = .003), vastus medialis obliquus (P = .04), and vastus lateralis (P = .005). Furthermore, the peroneus longus was activated earlier in the shoes-only (P = .02) and shoes-with-standard-foot-orthoses (P = .03) conditions than in the BF condition. No differences were observed for the hip muscles. Conclusions Earlier onset of muscle activity was most apparent in the SCFO

  6. Caregiver Reports of Children’s Activity Participation Following Serious Injury

    PubMed Central

    Braaf, Sandra; Ameratunga, Shanthi; Teague, Warwick; Jowett, Helen; Gabbe, Belinda

    2016-01-01

    Paediatric trauma can result in significant levels of on-going disability. The aim of this study was to explore the restrictions on activity participation that children experience following serious injury from the perspective of their caregivers. We performed a thematic analysis of transcripts of semi-structured in-depth interviews with the caregivers of 44 seriously injured children, conducted three-years after the injury, and purposively sampled from a population-based cohort study. Both temporary and on-going restrictions on school, sport, leisure and social activities were identified, some of which were imposed by caregivers, schools, or recommended by health providers. The perceived risk of further injury, physical restrictions, emotional state and fatigue levels were important influences on degrees of activity restriction. Children who were socially less engaged, especially those who were more severely injured, had difficulty making and retaining friends, and exhibited signs of depression or social withdrawal. The activities of pre-school children were strongly regulated by their caregivers, while school age children faced obstacles with participation in aspects such as study, sport, and peer and teacher relationships, affecting learning, school attendance and enjoyment. The findings highlight the need for primary prevention and reducing the impacts of serious injury throughout the continuum of care. PMID:27399741

  7. Mechanism for macrophage activation against Corynebacterium parvum--participation of T cells and its lymphokines.

    PubMed

    Mori, H; Mihara, M; Uesugi, Y; Nagai, H; Koda, A

    1994-01-01

    It is well known that Corynebacterium parvum activates macrophages to produce tumor necrosis factor (TNF). It is suspected that the activation of macrophages by C. parvum requires T-cell participation. The purpose of this study was to confirm that T cells participate in the activation of macrophages by C. parvum. TNF production in vitro from the spleen cells of BALB/c(-)+/+ mice was abrogated completely by the pre-treatment of spleen cells with anti-Ia antiserum and complement, indicating that Ia+ cells are the source of TNF. TNF production was not elicited at all in BALB/c-nu/nu mice. However, there was an increase in the number of Ia+ cells as well as an increase in the weight of spleen and liver. Supernatant from a culture of spleen cells stimulated with phytohemagglutinin-P (a PHA-induced lymphokine) made it possible for BALB/c-nu/nu mice to produce TNF, associated with an induction of Lyt-1+ cells and Lyt-2+ cells. However, treatment with the lymphokine did not augment the increases of Ia+ cells or liver and spleen weights. These results suggest that increasing the number of Ia+ cells is not sufficient to bring about TNF production; Ia+ cells must also be stimulated by T cells or T-cell lymphokines in order to produce TNF. These results suggest that T cells play an essential role in the activation of Ia+ cells against C. parvum. PMID:7723692

  8. Flying the "Active School Flag": Physical Activity Promotion through Self-Evaluation in Primary Schools in Ireland

    ERIC Educational Resources Information Center

    Chroinin, Deirdre Ni; Murtagh, Elaine; Bowles, Richard

    2012-01-01

    Primary schools are key sites where children can be active, advance their knowledge and understanding of how to participate in physical activity (PA) and develop an appreciation of its importance in their lives. This study explored the role of schools in promoting PA asking: how do primary schools approach the promotion of whole-school PA? Data…

  9. Enabling Remote Activity: Using mobile technology for remote participation in geoscience fieldwork

    NASA Astrophysics Data System (ADS)

    Davies, Sarah; Collins, Trevor; Gaved, Mark; Bartlett, Jessica; Valentine, Chris; McCann, Lewis

    2010-05-01

    Field-based activities are regarded as essential to the development of a range of professional and personal skills within the geosciences. Students enjoy field activities, preferring these to learning with simulations (Spicer and Stratford 2001), and these improve deeper learning and understanding (Kern and Carpenter, 1984; Elkins and Elkins, 2007). However, some students find it difficult to access these field-based learning opportunities. Field sites may be remote and often require travel across uneven, challenging or potentially dangerous terrain. Mobility-impaired students are particularly limited in their opportunities to participate in field-based learning activities and, as higher education institutions have a responsibility to provide inclusive opportunities for students (UK Disability Discrimination Act 1995, UK Special Education Needs and Disability Rights Act 2001), the need for inclusive fieldwork learning is being increasingly recognised. The Enabling Remote Activity (ERA) project has been investigating how mobile communications technologies might allow field learning experiences to be brought to students who would otherwise find it difficult to participate, and also to enhance activities for all participants. It uses a rapidly deployable, battery-powered wireless network to transmit video, audio, and high resolution still images to connect participants at an accessible location with participants in the field. Crucially, the system uses a transient wireless network, allowing multiple locations to be explored during a field visit, and for plans to be changed dynamically if required. Central to the concept is the requirement for independent investigative learning: students are enabled to participate actively in the learning experience and to direct the investigations, as opposed to being simply remote viewers of the experience. Two ways of using the ERA system have been investigated: remote access and collaborative groupwork. In 2006 and 2008 remote

  10. Barriers to participation in physical activity and exercise among middle-aged and elderly individuals.

    PubMed

    Justine, Maria; Azizan, Azliyana; Hassan, Vaharli; Salleh, Zoolfaiz; Manaf, Haidzir

    2013-10-01

    INTRODUCTION Although the benefits of physical activity and exercise are widely acknowledged, many middle-aged and elderly individuals remain sedentary. This cross-sectional study aimed to identify the external and internal barriers to physical activity and exercise participation among middle-aged and elderly individuals, as well as identify any differences in these barriers between the two groups. METHODS Recruited individuals were categorised into either the middle-aged (age 45-59 years, n = 60) or elderly (age ≥ 60 years, n = 60) group. Data on demographics, anthropometry, as well as external and internal barriers to participation in physical activity and exercise were collected. RESULTS Analysis showed no significant differences in the total scores of all internal barriers between the two groups (p > 0.05). The total scores for most external barriers between the two groups also showed no significant differences (p > 0.05); only 'cost' (p = 0.045) and 'exercise interferes with social/family activities' (p = 0.011) showed significant differences. The most common external barriers among the middle-aged and elderly respondents were 'not enough time' (46.7% vs. 48.4%), 'no one to exercise with' (40.0% vs. 28.3%) and 'lack of facilities' (33.4% vs. 35.0%). The most common internal barriers for middle-aged respondents were 'too tired' (48.3%), 'already active enough' (38.3%), 'do not know how to do it' (36.7%) and 'too lazy' (36.7%), while those for elderly respondents were 'too tired' (51.7%), 'lack of motivation' (38.4%) and 'already active enough' (38.4%). CONCLUSION Middle-aged and elderly respondents presented with similar external and internal barriers to physical activity and exercise participation. These factors should be taken into account when healthcare policies are being designed and when interventions such as the provision of facilities to promote physical activity and exercise among older people are being considered. PMID:24154584

  11. Getting kids active by participating in sport and doing It more often: focusing on what matters

    PubMed Central

    2012-01-01

    Background Reduced time dedicated to physical education and free play in recent decades emphasizes the need to promote opportunities for sport participation in adolescents in order to increase physical activity levels. The purpose of this study was to examine the association of sociodemographic and biological characteristics, behavioural patterns, and school-related and sport-specific variables with time spent participating in sport. Methods A total of 1837 secondary school students (age: 14.6 ± 1.2 years; 50.9 % boys) from 19 of 23 schools in the Otago Region (New Zealand) completed an online sport survey and Youth Physical Activity Questionnaire in 2009. Using multilevel modeling, we examined the association of individual-, school- and sport-related variables on sport participation and the amount of time spent in sports. Results Higher rates of sport participation were associated with lower neighbourhood deprivation scores (OR (95%CI): 0.75 (0.49-1.14), 0.57 (0.38-0.86), 0.48 (0.28-0.81)), higher quintiles of physical activity (2.89 (2.10-3.96), 2.81 (1.68-4.70), 3.54 (2.24-5.57), 3.97 (1.99-7.95)), highest quintiles of screen time (1.58 (0.94-2.65), 1.99 (1.42-2.80), 2.17 (1.43-3.30), 1.88 (1.37-2.57)) and boys only school status (2.21 (1.57-3.10)). Greater amount of time spent in sports was associated with male gender (0.56 (0.43-0.74), lower neighbourhood deprivation scores (0.72 (0.59-0.93), 0.78 (0.58-1.04), 0.62 (0.39-1.00)), higher quintiles of physical activity (3.18 (2.29-4.41), 4.25 (2.91-6.20), 8.33 (5.58-12.44), 6.58 (4.07-10.64)), highest quintile of screen time (1.83 (1.31-2.56), greater availability of sports outside school (1.68 (1.22-2.32)), better sport management (2.57 (1.63-4.07)) and provision of sport courts at school (0.57 (0.40-0.81)). Conversely, obesity was associated with less time spent participating in sport (0.50 (0.31-0.80)). Conclusion Results support the use of sport participation as an effective strategy to increase

  12. Increasing Physical Activity and Participation in People With Multiple Sclerosis: A Review.

    PubMed

    Backus, Deborah

    2016-09-01

    Multiple sclerosis (MS) is a chronic progressive disease of the central nervous system (CNS) affecting >2.5 million people worldwide. Damage to neurons in the CNS causes various sensorimotor and cognitive symptoms, such as fatigue, pain, spasticity, memory deficits, and impairment of mobility. Until the late 1990s, it was believed that symptoms of MS would be worsened with physical exertion and people with MS were encouraged to limit physical activity and exertion. Not only has emerging evidence suggested that physical activity, including exercise, is safe for people with MS, there is also evidence that at least some of the disability that occurs after MS is due to secondary deconditioning from the sedentary lifestyle adopted because of the symptoms of MS, not just CNS damage alone. Therefore, not only is physical activity safe, it is also required for maintaining function and health in people with MS. The purpose of this article is to review the unique physical and social barriers to physical activity in people with MS, including those with moderate to severe disability who use a wheelchair or scooter for mobility. We will discuss how existing guidelines for physical activity may not meet the needs of people with MS and present evidence-based considerations for promoting physical activity in people with MS. Ultimately, the goal is to overcome the barriers to physical activity and improve health, participation, and quality of life in people with MS. PMID:27211007

  13. Findings from HFRP's Study of Predictors of Participation in Out-of-School Time Activities: Fact Sheet

    ERIC Educational Resources Information Center

    Harvard Family Research Project, 2007

    2007-01-01

    Participation in various structured out-of-school time (OST) activities benefits youth socially, emotionally, and academically and may have the most positive effects for youth who are most at risk. Little research, however, has explored the questions of who participates in OST activities and why. The Harvard Family Research Project examined the…

  14. Activity Participation Intensity Is Associated with Skeletal Development in Pre-Pubertal Children with Developmental Coordination Disorder

    ERIC Educational Resources Information Center

    Tsang, William W. N.; Guo, X.; Fong, Shirley S. M.; Mak, Kwok-Kei; Pang, Marco Y. C.

    2012-01-01

    Purpose: This study aimed (1) to compare the skeletal maturity and activity participation pattern between children with and without developmental coordination disorder (DCD); and (2) to determine whether activity participation pattern was associated with the skeletal development among children with DCD. Materials and methods: Thirty-three children…

  15. Exploring How Factors Impact the Activities and Participation of Persons with Disability: Constructing a Model through Grounded Theory

    ERIC Educational Resources Information Center

    Wee, Joy; Paterson, Margo

    2009-01-01

    This paper explores a conceptualization of how factors impact activities of daily living (ADL) and participation from the perspective of persons with disability. This study identified what, and how, factors perceived by participants affect their daily activities, to better inform reporting of scores obtained on measures of ADLs and participation…

  16. How Do Changes in Body Functions and Structures, Activity, and Participation Relate in Children with Cerebral Palsy?

    ERIC Educational Resources Information Center

    Wright, F. Virginia; Rosenbaum, Peter L.; Goldsmith, Charles H.; Law, Mary; Fehlings, Darcy L.

    2008-01-01

    Rehabilitation increasingly addresses the International Classification of Functioning, Disability and Health's (ICF) concepts of activity and participation, but little is known about associations between changes in body functions and structures, activity, and participation. We conducted a before-and-after study of 35 ambulatory children with…

  17. Motor Ability and Weight Status Are Determinants of Out-of-School Activity Participation for Children with Developmental Coordination Disorder

    ERIC Educational Resources Information Center

    Fong, Shirley S. M.; Lee, Velma Y. L.; Chan, Nerita N. C.; Chan, Rachel S. H.; Chak, Wai-Kwong; Pang, Marco Y. C.

    2011-01-01

    According to the International Classification of Functioning, Disability and Health model endorsed by the World Health Organization, participation in everyday activities is integral to normal child development. However, little is known about the influence of motor ability and weight status on physical activity participation in children with…

  18. Picture Me Playing--A Portrait of Participation and Enjoyment of Leisure Activities in Adolescents with Cerebral Palsy

    ERIC Educational Resources Information Center

    Shikako-Thomas, Keiko; Shevell, Michael; Lach, Lucyna; Law, Mary; Schmitz, Norbert; Poulin, Chantal; Majnemer, Annette

    2013-01-01

    In recent years attention has been paid to the participation levels of children and youth with Cerebral Palsy (CP), particularly the extent to which they have the opportunity to be involved in and enjoy leisure activities. The objective of this study is to describe the level of participation and enjoyment in leisure activities among adolescents…

  19. Impact of Organized Sports on Activity, Participation, and Quality of Life in People With Neurologic Disabilities.

    PubMed

    Sahlin, K Barbara; Lexell, Jan

    2015-10-01

    Physical activity and exercise is the mainstay of chronic disease prevention and health maintenance for all people with and without a disability, and clear evidence exists of the benefits among various populations with neurologic disabilities. However, the potential benefits of organized sports for people with neurologic disabilities are not as well explored. In this narrative review, current evidence regarding the impact of organized sports on activity, participation, and quality of life in people with neurologic disabilities of all ages is summarized, and facilitators of and barriers to participation in sports for this population are discussed. The articles reviewed were divided into 2 sets: (1) children and adolescents and (2) adults. The subjects of almost all of the studies were persons with a spinal cord injury. Children and adolescents with a disability who engaged in sports reported self-concept scores close to those of able-bodied athletes, as well as higher levels of physical activity. Adults with a spinal cord injury who engaged in organized sports reported decreased depression and anxiety, increased life satisfaction, and increased opportunity for gainful employment compared with nonathletic persons with disabilities. General facilitators, regardless of age, were fitness, fun, health, competence, and social aspects, whereas overall barriers were lack of or inappropriate medical advice and facilities, decreased self-esteem, poor finances, dependency on others, and views held by others. The importance of this topic for further research is highlighted, and suggestions for future studies are proposed. PMID:25828205

  20. Sleep is associated with task-negative brain activity in fibromyalgia participants with comorbid chronic insomnia.

    PubMed

    Vatthauer, Karlyn E; Craggs, Jason G; Robinson, Michael E; Staud, Roland; Berry, Richard B; Perlstein, William M; McCrae, Christina S

    2015-01-01

    Patients with chronic pain exhibit altered default mode network (DMN) activity. This preliminary project questioned whether comorbid disease states are associated with further brain alterations. Thirteen women with fibromyalgia (FM) only and 26 women with fibromyalgia with comorbid chronic insomnia (FMI) underwent a single night of ambulatory polysomnography and completed a sleep diary each morning for 14 days prior to performing a neuroimaging protocol. Novel imaging analyses were utilized to identify regions associated with significantly disordered sleep that were more active in task-negative periods than task-oriented periods in participants with FMI, when compared to participants with FM. It was hypothesized that core DMN areas (ie, cingulate cortex, inferior parietal lobule, medial prefrontal cortex, medial temporal cortex, precuneus) would exhibit increased activity during task-negative periods. Analyses revealed that significantly disordered sleep significantly contributed to group differences in the right cingulate gyrus, left lentiform nucleus, left anterior cingulate, left superior gyrus, medial frontal gyrus, right caudate, and the left inferior parietal lobules. Results suggest that FMI may alter some brain areas of the DMN, above and beyond FM. However, future work will need to investigate these results further by controlling for chronic insomnia only before conclusions can be made regarding the effect of FMI comorbidity on the DMN. PMID:26648751

  1. Impact of Organized Sports on Activity, Participation, and Quality of Life in People With Neurologic Disabilities.

    PubMed

    Sahlin, K Barbara; Lexell, Jan

    2015-10-01

    Physical activity and exercise is the mainstay of chronic disease prevention and health maintenance for all people with and without a disability, and clear evidence exists of the benefits among various populations with neurologic disabilities. However, the potential benefits of organized sports for people with neurologic disabilities are not as well explored. In this narrative review, current evidence regarding the impact of organized sports on activity, participation, and quality of life in people with neurologic disabilities of all ages is summarized, and facilitators of and barriers to participation in sports for this population are discussed. The articles reviewed were divided into 2 sets: (1) children and adolescents and (2) adults. The subjects of almost all of the studies were persons with a spinal cord injury. Children and adolescents with a disability who engaged in sports reported self-concept scores close to those of able-bodied athletes, as well as higher levels of physical activity. Adults with a spinal cord injury who engaged in organized sports reported decreased depression and anxiety, increased life satisfaction, and increased opportunity for gainful employment compared with nonathletic persons with disabilities. General facilitators, regardless of age, were fitness, fun, health, competence, and social aspects, whereas overall barriers were lack of or inappropriate medical advice and facilities, decreased self-esteem, poor finances, dependency on others, and views held by others. The importance of this topic for further research is highlighted, and suggestions for future studies are proposed.

  2. Sleep is associated with task-negative brain activity in fibromyalgia participants with comorbid chronic insomnia

    PubMed Central

    Vatthauer, Karlyn E; Craggs, Jason G; Robinson, Michael E; Staud, Roland; Berry, Richard B; Perlstein, William M; McCrae, Christina S

    2015-01-01

    Patients with chronic pain exhibit altered default mode network (DMN) activity. This preliminary project questioned whether comorbid disease states are associated with further brain alterations. Thirteen women with fibromyalgia (FM) only and 26 women with fibromyalgia with comorbid chronic insomnia (FMI) underwent a single night of ambulatory polysomnography and completed a sleep diary each morning for 14 days prior to performing a neuroimaging protocol. Novel imaging analyses were utilized to identify regions associated with significantly disordered sleep that were more active in task-negative periods than task-oriented periods in participants with FMI, when compared to participants with FM. It was hypothesized that core DMN areas (ie, cingulate cortex, inferior parietal lobule, medial prefrontal cortex, medial temporal cortex, precuneus) would exhibit increased activity during task-negative periods. Analyses revealed that significantly disordered sleep significantly contributed to group differences in the right cingulate gyrus, left lentiform nucleus, left anterior cingulate, left superior gyrus, medial frontal gyrus, right caudate, and the left inferior parietal lobules. Results suggest that FMI may alter some brain areas of the DMN, above and beyond FM. However, future work will need to investigate these results further by controlling for chronic insomnia only before conclusions can be made regarding the effect of FMI comorbidity on the DMN. PMID:26648751

  3. Anger expression and natural killer cell activity in family caregivers participating in a physical activity trial.

    PubMed

    Wilcox, S; King, A C; Vitaliano, P P; Brassington, G S

    2000-07-01

    Associations between psychological functioning and natural killer cell activity (NKA) were examined in 23 older (62.2 ± 7.5 years) family caregivers randomized to a moderate intensity four-month exercise program or to a wait-list control condition. At baseline, although NKA was related to anger-control (r = -.42; trend p < .06) and anger-out (r = .50; p < .03), it was not related to depression, anxiety, perceived stress, or caregiver burden. After controlling for baseline NKA, changes in anger-control explained 14 percent of the variance in NKA four months later. Decreases in anger-control predicted increases in NKA. Group assignment (exercise vs control) was unrelated to changes in NKA over the four-month period; however, the study was not powered to detect this effect. These results are consistent with reported relationships of anger expression with other physiological measures, and extend the importance of anger expression to immune functioning in older family caregivers.

  4. MCHergic projections to the nucleus pontis oralis participate in the control of active (REM) sleep.

    PubMed

    Torterolo, Pablo; Sampogna, Sharon; Chase, Michael H

    2009-05-01

    Neurons that utilize melanin-concentrating hormone (MCH) as a neuromodulator are located in the lateral hypothalamus and incerto-hypothalamic area and project diffusely throughout the central nervous system, including areas that participate in the generation and maintenance of sleep and wakefulness. Recent studies have shown that hypothalamic MCHergic neurons are active during active sleep (AS), and that intraventricular microinjections of MCH induce AS sleep; however, there are no data available regarding the manner in which MCHergic neurons participate in the control of this behavioral state. Utilizing immunohistochemical and retrograde tracing techniques, we examined, in the cat, projections from MCHergic neurons to the nucleus pontis oralis (NPO), which is considered to be the executive area that is responsible for the generation and maintenance of AS. In addition, we explored the effects on sleep and waking states produced by the microinjection of MCH into the NPO. We first determined that MCHergic fibers and terminals are present in the NPO. We also found that when a retrograde tracer (cholera toxin subunit B) was placed in the NPO MCHergic neurons of the hypothalamus were labeled. When MCH was microinjected into the NPO, there was a significant increase in the amount of AS (19.8+/-1.4% versus 11.9+/-0.2%, P<0.05) and a significant decrease in the latency to AS (10.4+/-4.2 versus 26.6+/-2.3 min, P<0.05). The preceding anatomical and functional data support our hypothesis that the MCHergic system participates in the regulation of AS by modulating neuronal activity in the NPO. PMID:19269278

  5. MCHergic projections to the nucleus pontis oralis participate in the control of active (REM) sleep.

    PubMed

    Torterolo, Pablo; Sampogna, Sharon; Chase, Michael H

    2009-05-01

    Neurons that utilize melanin-concentrating hormone (MCH) as a neuromodulator are located in the lateral hypothalamus and incerto-hypothalamic area and project diffusely throughout the central nervous system, including areas that participate in the generation and maintenance of sleep and wakefulness. Recent studies have shown that hypothalamic MCHergic neurons are active during active sleep (AS), and that intraventricular microinjections of MCH induce AS sleep; however, there are no data available regarding the manner in which MCHergic neurons participate in the control of this behavioral state. Utilizing immunohistochemical and retrograde tracing techniques, we examined, in the cat, projections from MCHergic neurons to the nucleus pontis oralis (NPO), which is considered to be the executive area that is responsible for the generation and maintenance of AS. In addition, we explored the effects on sleep and waking states produced by the microinjection of MCH into the NPO. We first determined that MCHergic fibers and terminals are present in the NPO. We also found that when a retrograde tracer (cholera toxin subunit B) was placed in the NPO MCHergic neurons of the hypothalamus were labeled. When MCH was microinjected into the NPO, there was a significant increase in the amount of AS (19.8+/-1.4% versus 11.9+/-0.2%, P<0.05) and a significant decrease in the latency to AS (10.4+/-4.2 versus 26.6+/-2.3 min, P<0.05). The preceding anatomical and functional data support our hypothesis that the MCHergic system participates in the regulation of AS by modulating neuronal activity in the NPO.

  6. Participation in Types of Physical Activities Among US Adults—National Health and Nutrition Examination Survey 1999–2006

    PubMed Central

    Dai, Shifan; Carroll, Dianna D.; Watson, Kathleen B.; Paul, Prabasaj; Carlson, Susan A.; Fulton, Janet E.

    2015-01-01

    Background Information on specific types of physical activities in which US adults participate is important for community and program development to promote physical activity. Methods Prevalence of participation and average time spent for 33 leisure-time aerobic activities and 10 activity categories were calculated using self-reported data from 22,545 participants aged ≥ 18 years in the National Health and Nutrition Examination Survey 1999–2006. Results Overall, 38% of US adults reported no leisure-time physical activities, and 43% reported 1 or 2 activities in the past 30 days. Walking was the most frequently reported activity for both men (29%) and women (38%). Among walkers, the average time spent walking was 198 minutes/week for men and 152 minutes/week for women. The most reported activities for men after walking were bicycling and yard work, and for women were aerobics and dance. For most activity categories, participation was lower among adults aged ≥ 65 years than among younger adults, and among Mexican Americans and non-Hispanic blacks than among non-Hispanic whites. Participation in most categories increased with increasing educational attainment. Conclusions Participation in physical activity differs by types of activities and demographic characteristics. Physical activity promotion programs should take these differences into account when developing intervention strategies. PMID:26083795

  7. Composition of objectively measured physical activity and sedentary behaviour participation across the school-day, influence of gender and weight status: cross-sectional analyses among disadvantaged Victorian school children

    PubMed Central

    Strugnell, Claudia; Turner, Kyle; Malakellis, Mary; Hayward, Josh; Foster, Charlie; Millar, Lynne; Allender, Steve

    2016-01-01

    Background The after-school period has been described as the ‘critical window’ for physical activity (PA) participation. However, little is known about the importance of this window compared with the before and during-school period among socioeconomically disadvantaged children, and influence of gender and weight status. Methods 39 out of 156 (RR=25%) invited primary schools across 26 local government areas in Victoria, Australia, consented to participate with 856 children (RR=36%) participating in the wider study. The analysis sample included 298 Grade 4 and Grade 6 children (mean age: 11.2±1.1; 44% male) whom met minimum accelerometry wear-time criteria and had complete height, weight and health-behaviours questionnaire data. Accelerometry measured duration in daily light-intensity PA (LPA), moderate-to-vigorous PA (MVPA) and sedentary time (ST) was calculated for before-school=8–8:59, during-school=9:00–15:29 and after-school=15:30–18:00. Bivariate and multivariable linear regression analyses were conducted. Results During-school represented the greatest accumulation of LPA and MVPA compared with the before and after-school periods. Boys engaged in 102 min/day of LPA (95% CI 98.5 to 104.9) and 62 min/day of MVPA (95% CI 58.9 to 64.7) during-school; girls engaged in 103 min/day of LPA (95% CI 99.7 to 106.5) and 45 min/day of MVPA (95% CI 42.9 to 47.4). Linear regression models indicated that girls with overweight or obesity engaged in significantly less LPA, MVPA and more time in ST during-school. Conclusions This study highlights the importance of in-school PA compared with after-school PA among socioeconomically disadvantage children whom may have fewer resources to participate in after-school PA. PMID:27601489

  8. The pepsin residue glycine-76 contributes to active-site loop flexibility and participates in catalysis.

    PubMed Central

    Okoniewska, M; Tanaka, T; Yada, R Y

    2000-01-01

    Glycine residues are known to contribute to conformational flexibility of polypeptide chains, and have been found to contribute to flexibility of some loops associated with enzymic catalysis. A comparison of porcine pepsin in zymogen, mature and inhibited forms revealed that a loop (a flap), consisting of residues 71--80, located near the active site changed its position upon substrate binding. The loop residue, glycine-76, has been implicated in the catalytic process and thought to participate in a hydrogen-bond network aligning the substrate. This study investigated the role of glycine-76 using site-directed mutagenesis. Three mutants, G76A, G76V and G76S, were constructed to increase conformational restriction of a polypeptide chain. In addition, the serine mutant introduced a hydrogen-bonding potential at position 76 similar to that observed in human renin. All the mutants, regardless of amino acid size and polarity, had lower catalytic efficiency and activated more slowly than the wild-type enzyme. The slower activation process was associated directly with altered proteolytic activity. Consequently, it was proposed that a proteolytic cleavage represents a limiting step of the activation process. Lower catalytic efficiency of the mutants was explained as a decrease in the flap flexibility and, therefore, a different pattern of hydrogen bonds responsible for substrate alignment and flap conformation. The results demonstrated that flap flexibility is essential for efficient catalytic and activation processes. PMID:10861225

  9. Understanding physical activity participation in spinal cord injured populations: Three narrative types for consideration.

    PubMed

    Papathomas, Anthony; Williams, Toni L; Smith, Brett

    2015-01-01

    The aim of this study was to identity the types of physical activity narratives drawn upon by active spinal injured people. More than 50 h of semi-structured life-story interview data, collected as part of larger interdisciplinary program of disability lifestyle research, was analysed for 30 physically active male and female spinal cord injury (SCI) participants. A structural narrative analysis of data identified three narrative types which people with SCI draw on: (1) exercise is restitution, (2) exercise is medicine, and (3) exercise is progressive redemption. These insights contribute new knowledge by adding a unique narrative perspective to existing cognitive understanding of physical activity behaviour in the spinal cord injured population. The implications of this narrative typology for developing effective positive behavioural change interventions are critically discussed. It is concluded that the identified narratives types may be constitutive, as well as reflective, of physical activity experiences and therefore may be a useful tool on which to base physical activity promotion initiatives.

  10. Understanding physical activity participation in spinal cord injured populations: Three narrative types for consideration

    PubMed Central

    Papathomas, Anthony; Williams, Toni L.; Smith, Brett

    2015-01-01

    The aim of this study was to identity the types of physical activity narratives drawn upon by active spinal injured people. More than 50 h of semi-structured life-story interview data, collected as part of larger interdisciplinary program of disability lifestyle research, was analysed for 30 physically active male and female spinal cord injury (SCI) participants. A structural narrative analysis of data identified three narrative types which people with SCI draw on: (1) exercise is restitution, (2) exercise is medicine, and (3) exercise is progressive redemption. These insights contribute new knowledge by adding a unique narrative perspective to existing cognitive understanding of physical activity behaviour in the spinal cord injured population. The implications of this narrative typology for developing effective positive behavioural change interventions are critically discussed. It is concluded that the identified narratives types may be constitutive, as well as reflective, of physical activity experiences and therefore may be a useful tool on which to base physical activity promotion initiatives. PMID:26282868

  11. Reasons for non-participation in a primary care-based physical activity trial: a qualitative study

    PubMed Central

    Attwood, S; Morton, K L; Mitchell, J; Van Emmenis, M; Sutton, S

    2016-01-01

    Objectives To explore reasons for non-participation in a primary care-based physical activity trial and understand how these may contribute to recruitment of non-representative research samples. We also aimed to elicit non-participants’ own recommendations for enhancing trial uptake in primary care. Design Semistructured telephone interviews with non-participants to a randomised controlled trial of a very brief intervention for promoting physical activity conducted in primary care (the Very Brief Interventions trial), with thematic analysis of interview transcripts. Setting 5 general practice (GP) surgeries in the East of England, UK. Participants Interviews were completed with 10 female and 6 male non-participants of white ethnicity and aged between 40 and 71 years. 13 of the 16 interviewees were either active or moderately active according to the GP Physical Activity Questionnaire (GPPAQ). Results Interviewees discussed a range of reasons for non-participation. These included beliefs surrounding the personal relevance of the trial based on preconceptions of intervention content. Many interviewees considered themselves either sufficiently active or too functionally limited to increase activity levels further, so rendering participation pointless in their view. Other identified barriers included a lack of free time, for trial participation and for increasing physical activity, and dissatisfaction with appointment scheduling systems in place at GP surgeries. Interviewees questioned the appropriateness of primary care as a context for delivering interventions to promote physical activity. In general, interviewees were positively disposed towards the idea of trial participation, especially if personal benefits are made salient, but suggested that interventions could be delivered in a different setting such as the internet. Conclusions To increase participation in physical activity promotion trials conducted in primary care, the content of invitation materials and

  12. [Participation of one children hospital residents in scientific and training activities of Sociedad Argentina de Pediatría].

    PubMed

    Davenport, María Carolina; Domínguez, Paula Alejandra; Martins, Andrea Elizabeth

    2012-04-01

    The Sociedad Argentina de Pediatría, SAP (Argentine Society of Pediatrics) offers courses and scientific activities for pediatricians and residents. We evaluated the participation of Pedro de Elizalde Hospital residents in the scientific and training activities of SAP and assessed the trend of participation throughout the residency; 107 residents were surveyed; 48% were members, and the participation increased significantly throughout the residence (p <0.01). None of the surveyed residents were part of any association; 84% did not know the "Pediatricians in Training Group"; 49% participated in continued training programs, with a growing tendency to participation through-out the residency (p <0.01); 80% considered that the SAP is a friendly entity. We concluded that participation of residents in the SAP is scarce during the first two years of training, and that it shows a growth in the senior residents' group. Encouraging the interest of first and second year residents in the activities is necessary.

  13. Relationship between motor skills, participation in leisure activities and quality of life of children with Developmental Coordination Disorder: temporal aspects.

    PubMed

    Raz-Silbiger, S; Lifshitz, N; Katz, N; Steinhart, S; Cermak, S A; Weintraub, N

    2015-03-01

    The study examined the relationship between motor skills, participation in leisure activities and quality of life (QOL), within a temporal context (school year vs. summer vacation and school days vs. weekends). Parents of 22 children with Developmental Coordination Disorder (DCD) and of 55 typically developing children, aged 6-11, filled out two questionnaires relating to their children's participation in leisure activities (vigorous, moderate and sedentary) and QOL. The Movement Assessment Battery for Children-2 (MABC-2) was administered to their children. Results showed that among the children with DCD, balance scores positively correlated with participation in sedentary activities, and in both groups both balance and aiming and catching were related to the physical and school aspects of QOL. Furthermore, participation in vigorous activities in the summer was positively correlated with social and school QOL. In contrast, among typically developing children, participation in vigorous activities during the school year was negatively correlated with school QOL. Finally, in both groups, participation in sedentary activities during school days was negatively correlated with school QOL. These results suggest that the parents' perceptions of their children's QOL may be related to the level of activeness of the leisure activities but also to temporal aspects. Therefore, it is important that therapists and educators consider the temporal aspects, when consulting with parents and their children regarding participation in leisure activities.

  14. Cross-cultural adaptation of the Italian version of the Voice Activity Participation Profile.

    PubMed

    Fava, Gaetano; Paolillo, Nico Paolo; Oliveira, Gisele; Behlau, Mara

    2014-01-01

    The Vocal Activity Participation Profile (VAPP), originally developed in English, is a self-assessment tool used to measure individuals' voice activity limitation and participation restriction. Based on the fact that the cultural/linguistic adaptation is an essential step of validating a protocol in another language, the purpose was to linguistically and culturally adapt the VAPP into Italian. The adaptation was performed in accordance to the Scientific Advisory Committee of the Medical Outcomes Trust. The translation was performed by one bilingual speech-language pathologist and by one bilingual interpreter, who knew about the purpose of this project. A bilingual English teacher, who had not participated in the previous step, performed the back translation. A committee composed by three speech-language pathologists specialized in voice and one laryngologist compared the forward and backward translations, to assess for any discrepancies. A final version was produced and called Profilo di Attività e Partecipazione Vocale (PAPV). A "not applicable" option was included to each item and was administered to 17 individuals with voice problems, six males and 11 females, aged between 21 to 55 years. All items were relevant, as no patients chose the "not applicable" option. However, four individuals, who had a lower educational level, did not fully understand the instructions of the opening statement. Therefore, the questionnaire was further reviewed and adjusted to clarify the information. Otherwise, no items were changed and/or deleted. The PAPV kept the same structure as the original version. The cultural equivalence of the Italian VAPP was demonstrated and entitled PAPV, whose validation is currently in process. PMID:25118924

  15. [Digital democracy and experiences in e-participation: Internet activism and public policy].

    PubMed

    Araújo, Rafael de Paula Aguiar; Penteado, Cláudio Luis Camargo; Santos, Marcelo Burgos Pimentel dos

    2015-12-01

    The article explores processes of interaction between the State and organized civil society in an effort to assess the weight of the various social mobilization strategies utilized by different social organizations active in the city of São Paulo. The study is particularly interested in analyzing how the use of information and communications technology (ICT) influences the development of public policy as a means for shaping citizen opinion and establishing demands. A Political Participation and Influence Index was used to evaluate experiences in Internet activism in the city of São Paulo. Findings suggest that the movements and collectivities with the most inventive and broadest diversity of strategies achieve better results, signaling a new method of action in contemporary politics.

  16. [Digital democracy and experiences in e-participation: Internet activism and public policy].

    PubMed

    Araújo, Rafael de Paula Aguiar; Penteado, Cláudio Luis Camargo; Santos, Marcelo Burgos Pimentel dos

    2015-12-01

    The article explores processes of interaction between the State and organized civil society in an effort to assess the weight of the various social mobilization strategies utilized by different social organizations active in the city of São Paulo. The study is particularly interested in analyzing how the use of information and communications technology (ICT) influences the development of public policy as a means for shaping citizen opinion and establishing demands. A Political Participation and Influence Index was used to evaluate experiences in Internet activism in the city of São Paulo. Findings suggest that the movements and collectivities with the most inventive and broadest diversity of strategies achieve better results, signaling a new method of action in contemporary politics. PMID:26785869

  17. SPoRT's Participation in the GOES-R Proving Ground Activity

    NASA Technical Reports Server (NTRS)

    Jedlovec, Gary; Fuell, Kevin; Smith, Matthew; Stano, Geoffrey; Molthan, Andrew

    2011-01-01

    The next generation geostationary satellite, GOES-R, will carry two new instruments with unique atmospheric and surface observing capabilities, the Advanced Baseline Imager (ABI) and the Geostationary Lightning Mapper (GLM), to study short-term weather processes. The ABI will bring enhanced multispectral observing capabilities with frequent refresh rates for regional and full disk coverage to geostationary orbit to address many existing and new forecast challenges. The GLM will, for the first time, provide the continuous monitoring of total lightning flashes over a hemispherical region from space. NOAA established the GOES-R Proving Ground activity several years ago to demonstrate the new capabilities of these instruments and to prepare forecasters for their day one use. Proving Ground partners work closely with algorithm developers and the end user community to develop and transition proxy data sets representing GOES-R observing capabilities. This close collaboration helps to maximize refine algorithms leading to the delivery of a product that effectively address a forecast challenge. The NASA Short-term Prediction Research and Transition (SPoRT) program has been a participant in the NOAA GOES-R Proving Ground activity by developing and disseminating selected GOES-R proxy products to collaborating WFOs and National Centers. Established in 2002 to demonstrate the weather and forecasting application of real-time EOS measurements, the SPoRT program has grown to be an end-to-end research to operations activity focused on the use of advanced NASA modeling and data assimilation approaches, nowcasting techniques, and unique high-resolution multispectral data from EOS satellites to improve short-term weather forecasts on a regional and local scale. Participation in the Proving Ground activities extends SPoRT s activities and taps its experience and expertise in diagnostic weather analysis, short-term weather forecasting, and the transition of research and experimental

  18. SPoRT's Participation in the GOES-R Proving Ground Activity

    NASA Astrophysics Data System (ADS)

    Jedlovec, G.; Fuell, K.; Smith, M. R.; Stano, G. T.; Molthan, A.

    2011-12-01

    The next generation geostationary satellite, GOES-R, will carry two new instruments with unique atmospheric and surface observing capabilities, the Advanced Baseline Imager (ABI) and the Geostationary Lightning Mapper (GLM), to study short-term weather processes. The ABI will bring enhanced multispectral observing capabilities with frequent refresh rates for regional and full disk coverage to geostationary orbit to address many existing and new forecast challenges. The GLM will, for the first time, provide the continuous monitoring of total lightning flashes over a hemispherical region from space. NOAA established the GOES-R Proving Ground activity several years ago to demonstrate the new capabilities of these instruments and to prepare forecasters for their day one use. Proving Ground partners work closely with algorithm developers and the end user community to develop and transition proxy data sets representing GOES-R observing capabilities. This close collaboration helps to maximize refine algorithms leading to the delivery of a product that effectively address a forecast challenge. The NASA Short-term Prediction Research and Transition (SPoRT) program has been a participant in the NOAA GOES-R Proving Ground activity by developing and disseminating selected GOES-R proxy products to collaborating WFOs and National Centers. Established in 2002 to demonstrate the weather and forecasting application of real-time EOS measurements, the SPoRT program has grown to be an end-to-end research to operations activity focused on the use of advanced NASA modeling and data assimilation approaches, nowcasting techniques, and unique high-resolution multispectral data from EOS satellites to improve short-term weather forecasts on a regional and local scale. Participation in the Proving Ground activities extends SPoRT's activities and taps its experience and expertise in diagnostic weather analysis, short-term weather forecasting, and the transition of research and experimental

  19. A Retrospective Study of thrombolysis with 0.6 mg/kg Recombinant Tissue Plasminogen Activator (rt-PA) in Mild Stroke.

    PubMed

    Yang, Jie; Yu, Fei; Liu, Hong; An, Hedi; Xiong, Ran; Huang, Dongya

    2016-01-01

    We sought to assess the safety, effectiveness and cost of 0.6 mg/kg rt-PA treatment for patients with acute mild stroke and to compare that with 0.9 mg/kg. We retrospectively analyzed consecutive acute ischemic stroke patients who had a NIHSS score ≤5 at admission and who were treated with rt-PA within 4.5 hours of symptom onset. The demographic data, clinical outcomes and hospitalization cost were analyzed. A total of 108 patients were included. Forty six patients (42.6%) received a 0.6 mg/kg dosage of rt-PA. The baseline characteristics of the two groups were well matched (p > 0.05). Regarding the safety and effectiveness, the 0.6 mg/kg dosage group had a comparable proportion of symptomatic intracranial hemorrhage (sICH) (0.6 mg/kg, 4.3% vs 0.9 mg/kg, 4.8%; p > 0.05), early neurological deterioration (END) (19.6% vs 17.7%; p > 0.05), in-hospital mortality (4.3% vs 1.6%; p > 0.05), and a similar rate of favorable functional outcome (mRS score 0-1) at 3 months (73.9% vs 71.0%; p > 0.05) to those who received the standard dosage. However, the hospital cost was markedly lower in the 0.6 mg/kg group (0.6  mg/kg, 3,401.7 USD vs 0.9  mg/kg, 4,157.4 USD; p < 0.01). Our study suggest that 0.6 mg/kg rt-PA shared similar effectiveness and safety profile compared with that of 0.9 mg/kg in treating mild stroke, but cost less. PMID:27510959

  20. A Retrospective Study of thrombolysis with 0.6 mg/kg Recombinant Tissue Plasminogen Activator (rt-PA) in Mild Stroke

    PubMed Central

    Yang, Jie; Yu, Fei; Liu, Hong; An, Hedi; Xiong, Ran; Huang, Dongya

    2016-01-01

    We sought to assess the safety, effectiveness and cost of 0.6 mg/kg rt-PA treatment for patients with acute mild stroke and to compare that with 0.9 mg/kg. We retrospectively analyzed consecutive acute ischemic stroke patients who had a NIHSS score ≤5 at admission and who were treated with rt-PA within 4.5 hours of symptom onset. The demographic data, clinical outcomes and hospitalization cost were analyzed. A total of 108 patients were included. Forty six patients (42.6%) received a 0.6 mg/kg dosage of rt-PA. The baseline characteristics of the two groups were well matched (p > 0.05). Regarding the safety and effectiveness, the 0.6 mg/kg dosage group had a comparable proportion of symptomatic intracranial hemorrhage (sICH) (0.6 mg/kg, 4.3% vs 0.9 mg/kg, 4.8%; p > 0.05), early neurological deterioration (END) (19.6% vs 17.7%; p > 0.05), in-hospital mortality (4.3% vs 1.6%; p > 0.05), and a similar rate of favorable functional outcome (mRS score 0–1) at 3 months (73.9% vs 71.0%; p > 0.05) to those who received the standard dosage. However, the hospital cost was markedly lower in the 0.6 mg/kg group (0.6  mg/kg, 3,401.7 USD vs 0.9  mg/kg, 4,157.4 USD; p < 0.01). Our study suggest that 0.6 mg/kg rt-PA shared similar effectiveness and safety profile compared with that of 0.9 mg/kg in treating mild stroke, but cost less. PMID:27510959

  1. Patterns of Leisure-Time Physical Activity Participation in a British Birth Cohort at Early Old Age

    PubMed Central

    Martin, Kathryn R.; Cooper, Rachel; Harris, Tamara B.; Brage, Soren; Hardy, Rebecca; Kuh, Diana

    2014-01-01

    Using data from a nationally representative British birth cohort we characterized the type and diversity of leisure-time physical activity that 2,188 participants (age 60–64 years) engaged in throughout the year by gender and obesity. Participants most commonly reported walking (71%), swimming (33%), floor exercises (24%) and cycling (15%). Sixty-two percent of participants reported ≥2 activities in the past year and 40% reported diversity on a regular basis. Regular engagement in different types of activity (cardio-respiratory, balance/flexibility and strength) was reported by 67%, 19% and 11% of participants, respectively. We found gender differences, as well as differences by obesity status, in the activities reported, the levels of activity diversity and activity type. Non-obese participants had greater activity diversity, and more often reported activities beneficial for cardio-respiratory health and balance/flexibility than obese participants. These findings may be used to inform the development of trials of physical activity interventions targeting older adults, and those older adults with high body mass index. PMID:24911018

  2. p21-activated kinase 1 participates in vascular remodeling in vitro and in vivo.

    PubMed

    Hinoki, Akinari; Kimura, Keita; Higuchi, Sadaharu; Eguchi, Kunie; Takaguri, Akira; Ishimaru, Kazuhiro; Frank, Gerald D; Gerthoffer, William T; Sommerville, Laura J; Autieri, Michael V; Eguchi, Satoru

    2010-01-01

    Vascular smooth muscle cell hypertrophy, proliferation, or migration occurs in hypertension, atherosclerosis, and restenosis after angioplasty, leading to pathophysiological vascular remodeling. Angiotensin II and platelet-derived growth factor are well-known participants of vascular remodeling and activate a myriad of downstream protein kinases, including p21-activated protein kinase (PAK1). PAK1, an effector kinase of small GTPases, phosphorylates several substrates to regulate cytoskeletal reorganization. However, the exact role of PAK1 activation in vascular remodeling remains to be elucidated. Here, we have hypothesized that PAK1 is a critical target of intervention for the prevention of vascular remodeling. Adenoviral expression of dominant-negative PAK1 inhibited angiotensin II-stimulated vascular smooth muscle cell migration. It also inhibited vascular smooth muscle cell proliferation induced by platelet-derived growth factor. PAK1 was activated in neointima of the carotid artery after balloon injury in the rat. Moreover, marked inhibition of the neointima hyperplasia was observed in a dominant-negative PAK1 adenovirus-treated carotid artery after the balloon injury. Taken together, these results suggest that PAK1 is involved in both angiotensin II and platelet-derived growth factor-mediated vascular smooth muscle cell remodeling, and inactivation of PAK1 in vivo could be effective in preventing pathophysiological vascular remodeling.

  3. How does participation in inquiry-based activities influence gifted students' higher order thinking?

    NASA Astrophysics Data System (ADS)

    Reger, Barbara H.

    Inquiry-based learning is considered a useful technique to strengthen the critical thinking skills of students. The National Science Standards emphasize its use and the complexities and challenge it provides are well suited for meeting the needs of the gifted. While many studies have documented the effectiveness of this type of instruction, there is a lack of research on growth in higher-order thinking through participation in science inquiry. This study investigated such growth among a small group of gifted fifth-grade students. In this study a group of fifth-grade gifted science students completed a series of three forensics inquiry lessons, and documented questions, ideas and reflections as they constructed evidence to solve a crime. From this class of students, one small group was purposely selected to serve as the focus of the study. Using qualitative techniques, the questions and statements students made as they interacted in the activity were analyzed. Videotaped comments and student logs were coded for emerging patterns and also examined for evidence of increased levels of higher-order thinking based on a rubric that was designed using the six levels of Bloom's Taxonomy. Evidence from this study showed marked increase in and deeper levels of higher-order thinking for two of the students. The other boy and girl showed progress using the inquiry activities, but it was not as evident. The social dynamics of the group seemed to hinder one girl's participation during some of the activities. The social interactions played a role in strengthening the exchange of ideas and thinking skills for the others. The teacher had a tremendous influence over the production of higher-level statements by modeling that level of thinking as she questioned the students. Through her practice of answering a question with a question, she gradually solicited more analytical thinking from her students.

  4. Active lifestyles related to excellent self-rated health and quality of life: cross sectional findings from 194,545 participants in The 45 and Up Study

    PubMed Central

    2013-01-01

    Background Physical activity and sitting time independently contribute to chronic disease risk, though little work has focused on aspirational health outcomes. The purpose of this study was to examine associations between physical activity, sitting time, and excellent overall health (ExH) and quality of life (ExQoL) in Australian adults. Methods The 45 and Up Study is a large Australian prospective cohort study (n = 267,153). Present analyses are from 194,545 participants (48% male; mean age = 61.6 ± 10.7 yrs) with complete baseline questionnaire data on exposures, outcomes, and potential confounders (age, income, education, smoking, marital status, weight status, sex, residential remoteness and economic advantage, functional limitation and chronic disease). The Active Australia survey was used to assess walking, moderate, and vigorous physical activity. Sitting time was determined by asking participants to indicate number of hours per day usually spent sitting. Participants reported overall health and quality of life, using a five-point scale (excellent—poor). Binary logistic regression models were used to analyze associations, controlling for potential confounders. Results Approximately 16.5% of participants reported ExH, and 25.7% reported ExQoL. In fully adjusted models, physical activity was positively associated with ExH (AOR = adjusted odds ratio for most versus least active = 2.22, 95% CI = 2.20, 2.47; Ptrend < 0.001) and ExQoL (AOR for most versus least active = 2.30, 95% CI = 2.12, 2.49; Ptrend < 0.001). In fully adjusted models, sitting time was inversely associated with ExH (AOR for least versus most sitting group = 1.13, 95% CI = 1.09, 1.18; Ptrend < 0.001) and ExQoL (AOR for least versus most sitting group = 1.13, 95% CI = 1.10, 1.17; Ptrend < 0.001). In fully adjusted models, interactions between physical activity and sitting time were not significant for ExH (P = 0.118) or Ex

  5. Constraints of recreational sport participation: measurement invariance and latent mean differences across sex and physical activity status.

    PubMed

    Liu, Jing Dong; Chung, Pak Kwong; Chen, Wing Ping

    2014-10-01

    The purpose of the current study was to (a) examine the measurement invariance of the Constraint Scale of Sport Participation across sex and physical activity status among the undergraduate students (N = 630) in Hong Kong and (b) compare the latent mean differences across groups. Measurement invariance of the Constraint Scale of Sport Participation across sex of and physical activity status of the participants was examined first. With receiving support on the measurement invariance across groups, latent mean differences of the scores across groups were examined. Multi-group confirmatory factor analysis revealed that the configural, metric, scalar, and structural invariance of the scale was supported across groups. The results of latent mean differences suggested that the women reported significantly higher constraints on time, partner, psychology, knowledge, and interest than the men. The physically inactive participants reported significantly higher scores on all constraints except for accessibility than the physically active participants.

  6. Constraints of recreational sport participation: measurement invariance and latent mean differences across sex and physical activity status.

    PubMed

    Liu, Jing Dong; Chung, Pak Kwong; Chen, Wing Ping

    2014-10-01

    The purpose of the current study was to (a) examine the measurement invariance of the Constraint Scale of Sport Participation across sex and physical activity status among the undergraduate students (N = 630) in Hong Kong and (b) compare the latent mean differences across groups. Measurement invariance of the Constraint Scale of Sport Participation across sex of and physical activity status of the participants was examined first. With receiving support on the measurement invariance across groups, latent mean differences of the scores across groups were examined. Multi-group confirmatory factor analysis revealed that the configural, metric, scalar, and structural invariance of the scale was supported across groups. The results of latent mean differences suggested that the women reported significantly higher constraints on time, partner, psychology, knowledge, and interest than the men. The physically inactive participants reported significantly higher scores on all constraints except for accessibility than the physically active participants. PMID:25310228

  7. Factors that influence exercise activity among women post hip fracture participating in the Exercise Plus Program

    PubMed Central

    Resnick, Barbara; Orwig, Denise; D’Adamo, Christopher; Yu-Yahiro, Janet; Hawkes, William; Shardell, Michelle; Golden, Justine; Zimmerman, Sheryl; Magaziner, Jay

    2007-01-01

    Using a social ecological model, this paper describes selected intra- and interpersonal factors that influence exercise behavior in women post hip fracture who participated in the Exercise Plus Program. Model testing of factors that influence exercise behavior at 2, 6 and 12 months post hip fracture was done. The full model hypothesized that demographic variables; cognitive, affective, physical and functional status; pain; fear of falling; social support for exercise, and exposure to the Exercise Plus Program would influence self-efficacy, outcome expectations, and stage of change both directly and indirectly influencing total time spent exercising. Two hundred and nine female hip fracture patients (age 81.0 ± 6.9), the majority of whom were Caucasian (97%), participated in this study. The three predictive models tested across the 12 month recovery trajectory suggest that somewhat different factors may influence exercise over the recovery period and the models explained 8 to 21% of the variance in time spent exercising. To optimize exercise activity post hip fracture, older adults should be helped to realistically assess their self-efficacy and outcome expectations related to exercise, health care providers and friends/peers should be encouraged to reinforce the positive benefits of exercise post hip fracture, and fear of falling should be addressed throughout the entire hip fracture recovery trajectory. PMID:18044192

  8. Synthesis and antitubercular activity of 7-(R)- and 7-(S)-methyl-2-nitro-6-(S)-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazines, analogues of PA-824

    PubMed Central

    Li, Xiaojin; Manjunatha, Ujjini H.; Goodwin, Michael B.; Knox, John E.; Lipinski, Christopher A.; Keller, Thomas H.; Barry, Clifton E.; Dowd, Cynthia S.

    2008-01-01

    Nitroimidazoles such as PA-824 and OPC-67683 are currently in clinical development as members of a promising new class of therapeutics for tuberculosis. While the antitubercular activity of these compounds is high, they both suffer from poor water solubility thus complicating development. We determined the single-crystal X-ray structure of PA-824 and found a close packing of the nitroimidazoles facilitated by a pseudoaxial conformation of the p-trifluoromethoxybenzyl ether. To attempt to disrupt this tight packing by destabilizing the axial preference of this side chain, we prepared the two diastereomers of the 7-methyl-nitroimidazo-oxazine. Determination of the crystal structure of the 7-(S)-methyl derivative (5, cis) revealed that the benzylic side chain remained pseudoaxial while the 7-(R)-methyl derivative (6, trans) adopted the desired pseudoequatorial conformation. Both derivatives displayed similar activities against Mycobacterium tuberculosis, but neither showed improved aqueous solubility, suggesting that inherent lattice stability is not likely to be a major factor in limiting solubility. Conformational analysis revealed that all three compounds have similar energetically accessible conformations in solution. Additionally, these results suggest that the nitroreductase that initially recognizes PA-824 is somewhat insensitive to substitutions at the 7-position. PMID:18358721

  9. The Impact of External Employment on 12th Grade Student Participation in Extracurricular Activities as a Function of School Size

    ERIC Educational Resources Information Center

    Garcia, Miguel A.

    2012-01-01

    Data from the Educational Longitudinal Study of 2002 were used to compare 11,000 high school students on school size, time spent participating in extracurricular activities (ECA), and hours spent in employment. Findings indicated that students from small schools spent more time participating in ECA than students from larger schools for equivalent…

  10. The Effects of Constraint-Induced Movement Therapy on Activities Important to Independent School Participation of Children with Hemiparesis

    ERIC Educational Resources Information Center

    Carney, Joan

    2012-01-01

    This study investigated the efficacy of constraint-induced movement therapy (CI therapy) on activities important to school participation in children with hemiparesis. Four children, ages 4-0 to 7-10 participated in an intensive CI therapy program in a clinical setting. Constraining casts were worn 24 hours daily. Therapy was delivered 6 hours…

  11. An Analysis of Female Lecturers' Participation in Civil Engineering Research and Development Activities at One Polytechnic in Zimbabwe

    ERIC Educational Resources Information Center

    Chikuvadze, Pinias; Matswetu, Vimbai Sharon; Mugijima, Samuel

    2015-01-01

    This study sought to explore female lecturers' participation in civil engineering research and development activities at one polytechnic in Zimbabwe. Case study design was chosen for this study to make predictions, narration of events, comparisons and drawing of conclusions. The female lecturers were purposively sampled to participate in the…

  12. Self-Efficacy and Participation in Physical and Social Activity among Older Adults in Spain and the United States

    ERIC Educational Resources Information Center

    Perkins, Jessica M.; Multhaup, Kristi S.; Perkins, H. Wesley; Barton, Cole

    2008-01-01

    Purpose: We explored Bandura's self-efficacy theory as applied to older adult (aged 63-92) participation in physical and social activity in a cross-cultural study. Design and Methods: Older adults in Spain (n = 53) and the United States (n = 55) completed questions regarding self-efficacy, outcome expectancy, and participation in physical and…

  13. Status of Participation in Physical Activity among International Students Attending Colleges and Universities in the United States

    ERIC Educational Resources Information Center

    Yoh, Taeho; Yang, Heewon; Gordon, Brian

    2008-01-01

    This study examined the status of participation in physical activity among international students attending colleges and universities in the United States. Participants for the study were 521 international students from five universities in the Midwestern part of the United States. Descriptive statistics revealed that international college…

  14. The Relationship between Attitudes toward Participation in Physical Activities and Motives for Choosing Teaching Physical Education as a Career

    ERIC Educational Resources Information Center

    Al-Rawahi, Nasser; Al-Yarabi, Ali

    2013-01-01

    This study aims at investigating the relationship between physical education teachers' attitudes toward participation in physical activity and their motives toward choosing physical education as a teaching profession. Two questionnaires with a sample of 98 participants were employed as a data collection vehicle. The results showed that…

  15. Patterns and Predictors of Participation in Leisure Activities outside of School in Children and Adolescents with Cerebral Palsy

    ERIC Educational Resources Information Center

    Longo, Egmar; Badia, Marta; Orgaz, Begona M.

    2013-01-01

    This study analyzed the patterns and predictors of participation in leisure activities outside of school of Spanish children and adolescents with Cerebral Palsy (CP). Children and adolescents with CP (n = 199; 113 males and 86 females) participated in this cross-sectional study. Their mean age was 12.11 years (SD = 3.02; range 8-18 years), and…

  16. Environmental resources moderate the relationship between social support and school sports participation among adolescents: a cross-sectional analysis

    PubMed Central

    2011-01-01

    Background Most Americans are not active at recommended levels. Adolescence is a developmental period when physical activity (PA) decreases markedly. Methods This study investigates whether access to environmental PA resources moderates the relationship between psychosocial resources (social support and perceived competence) and PA among 192 adolescents. Results Environmental access to PA resources (determined via GIS-based assessment of the number of gyms, schools, trails, parks and athletic fields within 0.5 miles of each participant's home) moderated the association between social support and PA; among adolescents with high levels of environmental resources, greater social support was associated with students participating in a greater number of sports in school, whereas no such relationship emerged among adolescents with low environmental resources. Conclusions PA-promotion interventions should aim to enhance both social and environmental resources; targeting either one alone may be insufficient. PMID:21501504

  17. Race-related Disparities in Five-year Cognitive Level and Change in Untrained ACTIVE Participants

    PubMed Central

    Marsiske, Michael; Dzierzewski, Joseph M.; Thomas, Kelsey R.; Kasten, Linda; Jones, Rich; Johnson, Kathy; Willis, Sherry; Whitfield, Keith; Ball, Karlene; Rebok, George

    2013-01-01

    Objectives The current study examined five-year cognitive change in untrained African American and White participants from the ACTIVE study Methods Five year trajectories of memory, reasoning, visual processing speed/useful field of view, digit symbol substitution, and vocabulary were investigated. Education, health, gender, age and retest/practice effects were controlled for, and a missing data pattern mixture approach was used to adjust for dropout effects. Results After considering age, education health and gender, being African American uniquely explained 2% to 7% of the variance in cognitive performance. There were virtually no significant race differences in rates of change. Discussion Race-related results in the current study are consistent with previous research suggesting that social advantage factors like education have a stronger influence on level of performance than rate of change. The small remaining effects of being African American on performance levels likely reflect uncontrolled variation in factors like literacy and financial advantage. PMID:24385632

  18. Pseudomonas aeruginosa phage PaP1 DNA polymerase is an A-family DNA polymerase demonstrating ssDNA and dsDNA 3'-5' exonuclease activity.

    PubMed

    Liu, Binyan; Gu, Shiling; Liang, Nengsong; Xiong, Mei; Xue, Qizhen; Lu, Shuguang; Hu, Fuquan; Zhang, Huidong

    2016-08-01

    Most phages contain DNA polymerases, which are essential for DNA replication and propagation in infected host bacteria. However, our knowledge on phage-encoded DNA polymerases remains limited. This study investigated the function of a novel DNA polymerase of PaP1, which is the lytic phage of Pseudomonas aeruginosa. PaP1 encodes its sole DNA polymerase called Gp90 that was predicted as an A-family DNA polymerase with polymerase and 3'-5' exonuclease activities. The sequence of Gp90 is homologous but not identical to that of other A-family DNA polymerases, such as T7 DNA polymerases (Pol) and DNA Pol I. The purified Gp90 demonstrated a polymerase activity. The processivity of Gp90 in DNA replication and its efficiency in single-dNTP incorporation are similar to those of T7 Pol with processive thioredoxin (T7 Pol/trx). Gp90 can degrade ssDNA and dsDNA in 3'-5' direction at a similar rate, which is considerably lower than that of T7 Pol/trx. The optimized conditions for polymerization were a temperature of 37 °C and a buffer consisting of 40 mM Tris-HCl (pH 8.0), 30 mM MgCl2, and 200 mM NaCl. These studies on DNA polymerase encoded by PaP1 help advance our knowledge on phage-encoded DNA polymerases and elucidate PaP1 propagation in infected P. aeruginosa. PMID:27052734

  19. A pilot study on the feasibility of robot-aided leg motor training to facilitate active participation.

    PubMed

    Krishnan, Chandramouli; Ranganathan, Rajiv; Dhaher, Yasin Y; Rymer, William Z

    2013-01-01

    Robot-aided gait therapy offers a promising approach towards improving gait function in individuals with neurological disorders such as stroke or spinal cord injury. However, incorporation of appropriate control strategies is essential for actively engaging the patient in the therapeutic process. Although several control algorithms (such as assist-as-needed and error augmentation) have been proposed to improve active patient participation, we hypothesize that the therapeutic benefits of these control algorithms can be greatly enhanced if combined with a motor learning task to facilitate neural reorganization and motor recovery. Here, we describe an active robotic training approach (patient-cooperative robotic gait training combined with a motor learning task) using the Lokomat and pilot-tested whether this approach can enhance active patient participation during training. Six neurologically intact adults and three chronic stroke survivors participated in this pilot feasibility study. Participants walked in a Lokomat while simultaneously performing a foot target-tracking task that necessitated greater hip and knee flexion during the swing phase of the gait. We computed the changes in tracking error as a measure of motor performance and changes in muscle activation as a measure of active subject participation. Repeated practice of the motor-learning task resulted in significant reductions in target-tracking error in all subjects. Muscle activation was also significantly higher during active robotic training compared to simply walking in the robot. The data from stroke participants also showed a trend similar to neurologically intact participants. These findings provide a proof-of-concept demonstration that combining robotic gait training with a motor learning task enhances active participation.

  20. Assessing the impact participation in science journalism activities has on scientific literacy among high school students

    NASA Astrophysics Data System (ADS)

    Farrar, Cathy

    As part of the National Science Foundation Science Literacy through Science Journalism (SciJourn) research and development initiative (http://www.scijourn.org ; Polman, Saul, Newman, and Farrar, 2008) a quasi-experimental design was used to investigate what impact incorporating science journalism activities had on students' scientific literacy. Over the course of a school year students participated in a variety of activities culminating in the production of science news articles for Scijourner, a regional print and online high school science news magazine. Participating teachers and SciJourn team members collaboratively developed activities focused on five aspects of scientific literacy: placing information into context, recognizing relevance, evaluating factual accuracy, use of multiple credible sources and information seeking processes. This study details the development process for the Scientific Literacy Assessment (SLA) including validity and reliability studies, evaluates student scientific literacy using the SLA, examines student SLA responses to provide a description of high school students' scientific literacy, and outlines implications of the findings in relation to the National Research Council's A Framework for K-12 Science Education: Practices, Crosscutting Concepts, and Core Ideas (2012) and classroom science teaching practices. Scientifically literate adults acting as experts in the assessment development phase informed the creation of a scoring guide that was used to analyze student responses. Experts tended to draw on both their understanding of science concepts and life experiences to formulate answers; paying close attention to scientific factual inaccuracies, sources of information, how new information fit into their view of science and society as well as targeted strategies for information seeking. Novices (i.e., students), in contrast, tended to ignore factual inaccuracies, showed little understanding about source credibility and suggested

  1. Social participation and independence in activities of daily living: a cross sectional study

    PubMed Central

    Rubio, Encarnación; Lázaro, Angelina; Sánchez-Sánchez, Antonio

    2009-01-01

    Background It is today widely accepted that participation in social activities contributes towards successful ageing whilst, at the same time, maintaining independence in the activities of daily living (ADLs) is the sine qua non for achieving that end. This study looks at people aged 65 and over living in an urban area in Spain who retain the ability to attend Social Centres providing recreational facilities. The aim of this paper is to quantify independence and identify the risk factors involved in its deterioration. Methods The sample size was calculated using the equation for proportions in finite populations based on a random proportional sample type, absolute error (e) = 0.05, α = 0.05, β = 0.1, p = q = 0.5. Two-stage sampling was used. In the first place, the population was stratified by residence and a Social Centre was randomly chosen for each district. In the second stage, individuals were selected in a simple random sample without replacement in proportion to the number of members at each social centre. A multivariate logistical regression analysis takes functional ADL capacity as the dependent variable. The choice of predictive variables was made using a bivariate correlation matrix. Among the estimators obtained, Nagelkerke's R2 coefficient, and the Odds ratio (CI 95%) were considered. Sensitivity and 1-specificity were adopted to present the results in graphic form. Results Out of this sample, 63.7% were fully capable of carrying out ADLs, while the main factors contributing to deterioration, identified on the basis of a logistic regression model, are in order of importance, poor physical health, poor mental health, age (above 75 years) and gender (female). The model employed has a predictive value of 88% and 92% (depending on the age range considered) with regard to the independence in ADLs. Conclusion A review of the few Spanish works using similar methodology shows that the percentage of non-institutionalised persons who are independent enough to

  2. Factors Associated with Tweens' Intentions to Sustain Participation in an Innovative Community-Based Physical Activity Intervention

    ERIC Educational Resources Information Center

    DeBate, Rita D.; McDermott, Robert J.; Baldwin, Julie A.; Bryant, Carol A.; Courtney, Anita H.; Hogeboom, David L.; Nickelson, Jen; Phiilips, Leah M.; Alfonso, Moya L.

    2009-01-01

    Background: Participation in free-time play, including individual and group activities, is important during youth as patterns of physical activity established then persist into adulthood. The VERB Summer Scorecard (VSS) intervention is an innovative physical activity promotion initiative that offers tweens (8-13 year-olds) opportunities to be…

  3. A propensity score matching study of participation in community activities: a path to positive outcomes for youth in New Zealand?

    PubMed

    O'Connor, Seini; Jose, Paul E

    2012-11-01

    Extracurricular activities are important in many young people's lives and have been associated with positive academic, psychological, and social outcomes. However, most previous research has been limited to school-based activities in the North American context. This study expands existing literature by analyzing longitudinal data from more than 1,300 young Māori and European New Zealanders, using propensity score matching techniques to control for selection effects. Results suggest that youth participating in community-based activities experienced greater social support than nonparticipants. For Māori youth, participating in nonsports activities was associated with later benefits, while for New Zealand European youth, benefits were associated with sports activities. Participants of different ages reported different types of benefits. These findings highlight points of similarity and difference between New Zealand and North American youth and provide a better understanding of the positive impacts of community-based activities for young people.

  4. A propensity score matching study of participation in community activities: a path to positive outcomes for youth in New Zealand?

    PubMed

    O'Connor, Seini; Jose, Paul E

    2012-11-01

    Extracurricular activities are important in many young people's lives and have been associated with positive academic, psychological, and social outcomes. However, most previous research has been limited to school-based activities in the North American context. This study expands existing literature by analyzing longitudinal data from more than 1,300 young Māori and European New Zealanders, using propensity score matching techniques to control for selection effects. Results suggest that youth participating in community-based activities experienced greater social support than nonparticipants. For Māori youth, participating in nonsports activities was associated with later benefits, while for New Zealand European youth, benefits were associated with sports activities. Participants of different ages reported different types of benefits. These findings highlight points of similarity and difference between New Zealand and North American youth and provide a better understanding of the positive impacts of community-based activities for young people. PMID:22390671

  5. Participation of functionally active plasma cells in acute rejection and response to therapy in renal allografts.

    PubMed

    Bhat, Zeenat Yousuf; Bostwick, David G; Hossain, Deloar; Zeng, Xu

    2014-07-01

    Acute rejection (AR) includes T-cell-mediated and antibody-mediated rejection. The inflammatory infiltrate comprised not only T cells but also varying amounts of B cells (CD20(+)) and plasma cells (CD138(+)). The latter are associated with poor clinical outcomes, but their functional status is not clear. The phosphorylation of the S6 ribosomal protein (p-S6RP) is present in cells that are metabolically active, thus identifying functionally active antibody-secreting plasma cells. This study was designed to evaluate the clinical significance of functionally active p-S6RP plasma cells in AR in renal allografts. Renal allografts with biopsy evidence of AR during 2006-2009 were included. Immunohistochemistry staining for CD20, CD138, and p-S6RP was performed on paraffin-embedded slides and scaled as 0-6. The response to antirejection treatment was assessed by the serum creatinine ratio (CrR) at rejection episode (time 0) and following treatment (4 and 12 weeks). Patients with lower scores (0-2) were compared with a higher scored group (3-6). The T-test was conducted using statistical significance of p<0.05. A total of 28 patients (40.7 ± 14.3 year; M:F=15:13) were diagnosed with acute T-cell-mediated rejection (I and II). The p-S6RP staining in the high-score group had a significantly higher CrR (p<0.05) than the low-score group at the time of biopsy, 4 and 12 weeks following treatment. There was no significant difference in the CrR between groups for CD20 or CD138 staining. Functional antibody-secreting p-S6RP plasma cells are actively participating in AR and associated with poor response to treatment in renal allografts. PMID:24684655

  6. Epigenetic mediated transcriptional activation of WNT5A participates in arsenical-associated malignant transformation

    SciTech Connect

    Jensen, Taylor J.; Wozniak, Ryan J.; Eblin, Kylee E.; Wnek, Sean M.; Gandolfi, A. Jay; Futscher, Bernard W.

    2009-02-15

    Arsenic is a human carcinogen with exposure associated with cancer of the lung, skin, and bladder. Many potential mechanisms have been implicated as playing a role in the process of arsenical-induced malignancy including the perturbation of signaling pathways and aberrant epigenetic regulation. We initiated studies to examine the role of a member of the non-canonical WNT signaling pathway, WNT5A, in UROtsa cells and arsenite [URO-ASSC] and monomethylarsonous acid [URO-MSC] malignantly transformed variants. We present data herein that suggest that WNT5A is transcriptionally activated during arsenical-induced malignant transformation. This WNT5A transcriptional activation is correlated with the enrichment of permissive histone modifications and the reduction of repressive modifications in the WNT5A promoter region. The epigenetic activation of WNT5A expression and acetylation of its promoter remain after the removal of the arsenical, consistent with the maintenance of an anchorage independent growth phenotype in these cells. Additionally, treatment with epigenetic modifying drugs supports a functional role for these epigenetic marks in controlling gene expression. Reduction of WNT5A using lentiviral shRNA greatly attenuated the ability of these cells to grow in an anchorage independent fashion. Extension of our model into human bladder cancer cell lines indicates that each of the cell lines examined also express WNT5A. Taken together, these data suggest that the epigenetic remodeling of the WNT5A promoter is correlated with its transcriptional activation and this upregulation likely participates in arsenical-induced malignant transformation.

  7. How Do Young Children with DCD Participate and Enjoy Daily Activities?

    ERIC Educational Resources Information Center

    Bart, O.; Jarus, T.; Erez, Y.; Rosenberg, L.

    2011-01-01

    Developmental problems may decrease participation of children. The objective of this study was to evaluate multidimensional aspects of participation amongst preschool children with and without DCD. Participants included 63 children with mean age of 4.96 years (SD = 0.62; range = 4.02-6.35 years). Twenty one children were diagnosed with DCD, 21…

  8. Increasing Practitioners Knowledge of Participation Among Elderly Adults in Senior Center Activities

    ERIC Educational Resources Information Center

    Walker, Jan; Bisbee, Carol; Porter, Russell; Flanders, Joanne

    2004-01-01

    The research reported in this paper attempted to identify predictors of senior center participation and to ascertain why there has been a decline in the number of individuals participating at senior centers in recent years. The research reports the results of a survey conducted among senior center participants in an 11-county area in the Nortex…

  9. Increasing Practitioners' Knowledge of Participation among Elderly Adults in Senior Center Activities

    ERIC Educational Resources Information Center

    Walker, Jan; Bisbee, Carol; Porter, Russell; Flanders, Joanne

    2004-01-01

    The research reported in this paper attempted to identify predictors of senior center participation and to ascertain why there has been a decline in the number of individuals participating at senior centers in recent years. The research reports the results of a survey conducted among senior center participants in an 11-county area in the Nortex…

  10. Factors affecting student participation in extra-curricular activities: A comparison between two Middle Eastern dental schools

    PubMed Central

    Al-Ansari, Asim; Al-Harbi, Fahad; AbdelAziz, Wafaa; AbdelSalam, Maha; El Tantawi, Maha M.; ElRefae, Ismail

    2015-01-01

    Objective This study was conducted to assess the level of participation of dental undergraduate students in extracurricular activities (ECAs) and the factors affecting this participation. Methods The study included dental students enrolled in undergraduate programs at the Faculty of Dentistry, Alexandria University, Egypt, and the College of Dentistry, University of Dammam, Saudi Arabia. A questionnaire was developed to collect background information about students, their participation in ECAs, and time allocated for these activities. Students were asked about their perceptions of the relationship between ECAs and academic studies, and their reasons for participating in and satisfaction with ECAs. Results The study included 199 students from Alexandria and 146 students from Dammam, with response rates of 99.5% and 73%, respectively. The percentages of those reporting ECA participation were 27.1% and 43.8%, respectively, mostly in community service, sports, and social activities. About 60% of students did not think that ECAs affected their studies, although the perceived difficulty of balancing ECAs and academics was associated with lower odds of participation (odds ratio = 0.51). Most students participated in ECAs to socialize and make friends, and the majority was dissatisfied with school-organized ECAs (52% and 59%, respectively). Gender and/or perceived relation between ECAs and academic studies affected actual participation in ECAs in one school but not the other. Conclusions ECA participation among these students was low. Gender and perception of ECAs in relation to academic studies affected ECA participation differently in the two schools. Better planning and management of ECAs that incorporate students’ preferences and reasons for participation is needed. Gender issues and the relationship between ECAs and academic performance should be addressed in relation to school and social characteristics. PMID:26792968

  11. Responsibilities of the active participation of geoscientists in public funded projects

    NASA Astrophysics Data System (ADS)

    Correia, Victor; Fernandez, Isabel

    2016-04-01

    The European Federation of Geologists (EFG) is based in 24 European countries and represents over 50,000 geoscientists in Europe, working in organisations dealing with many of the critical societal challenges that came with fast population growing: soils fertility; fresh water; energy; and raw materials supply. This calls for the concerted contribution of networks of geoscientists to frame and answer the global challenges we are facing. In Europe, the Research and Innovation funding program Horizon 2020 provided a unique opportunity for EFG to play an active role in this context, and this justifies the direct involvement of EFG in several funded projects, ranging from international cooperation on raw materials supply to groundwater research or combined heat, power and metal extraction from ultra-deep ore bodies. But an active participation of a not for profit organization of geoscientists in such public funded projects brings responsibilities and reputational risks. The authors will describe how EFG is taking these responsibilities and facing the correspondent risks, through the involvement of certified professionals. The authors will highlight why EFG is keen in promoting the EurGeol professional title, ensuring title holders are skilled and competent to deliver high quality services within the practice of geology, framed by a Code of Ethics and a commitment towards continuing professional development.

  12. Activity limitations and participation restrictions in women with hand osteoarthritis: patients' descriptions and associations between dimensions of functioning

    PubMed Central

    Kjeken, I; Dagfinrud, H; Slatkowsky-Christ..., B; Mowinckel, P; Uhlig, T; Kvien, T; Finset, A

    2005-01-01

    Objective: To describe the functional consequences of hand osteoarthritis, and analyse associations between personal factors, hand impairment, activity limitations, and participation restrictions within the framework of the International Classification of Functioning (ICF). Methods: 87 women with hand osteoarthritis completed a clinical examination including recording of sociodemographic data, measures of hand impairment, and completion of self reported health status measures. The function subscale of the AUSCAN Osteoarthritis Hand Index was used as a measure of hand related activity limitations, while the Canadian Occupational Performance Measure (COPM) was used to describe and measure activity limitations and participation restrictions as perceived by the individual. The study variables were categorised using the dimensions in the ICF framework and analysed using bivariate and multivariate statistical approaches. Results: The patients described problems in many domains of activity and participation. The most frequently described hand related problems were activities requiring considerable grip strength combined with twisting of the hands. On the impairment level, the patients had reduced grip force and joint mobility in the hands, and resisted motion was painful. Regression analyses showed that hand related activity limitations were associated with measures of hand impairment, while activity and participation (as measured by the COPM) were more strongly associated with personal factors than with hand impairment. Conclusions: Hand osteoarthritis has important functional consequences in terms of pain, reduced hand mobility and grip force, activity limitations, and participation restrictions. Rehabilitation programmes should therefore be multidisciplinary and multidimensional, focusing on hand function, occupational performance, and coping strategies. PMID:15829571

  13. Household Factors Influencing Participation in Bird Feeding Activity: A National Scale Analysis

    PubMed Central

    Davies, Zoe G.; Fuller, Richard A.; Dallimer, Martin; Loram, Alison; Gaston, Kevin J.

    2012-01-01

    Ameliorating pressures on the ecological condition of the wider landscape outside of protected areas is a key focus of conservation initiatives in the developed world. In highly urbanized nations, domestic gardens can play a significant role in maintaining biodiversity and facilitating human-wildlife interactions, which benefit personal and societal health and well-being. The extent to which sociodemographic and socioeconomic factors are associated with engagement in wildlife gardening activities remain largely unresolved. Using two household-level survey datasets gathered from across Britain, we determine whether and how the socioeconomic background of a household influences participation in food provision for wild birds, the most popular and widespread form of human-wildlife interaction. A majority of households feed birds (64% across rural and urban areas in England, and 53% within five British study cities). House type, household size and the age of the head of the household were all important predictors of bird feeding, whereas gross annual household income, the occupation of the head of the household, and whether the house is owned or rented were not. In both surveys, the prevalence of bird feeding rose as house type became more detached and as the age of the head of the household increased. A clear, consistent pattern between households of varying size was less evident. When regularity of food provision was examined in the study cities, just 29% of households provided food at least once a week. The proportion of households regularly feeding birds was positively related to the age of the head of the household, but declined with gross annual income. As concerns grow about the lack of engagement between people and the natural environment, such findings are important if conservation organizations are successfully to promote public participation in wildlife gardening specifically and environmentally beneficial behaviour in society more generally. PMID:22761872

  14. Household factors influencing participation in bird feeding activity: a national scale analysis.

    PubMed

    Davies, Zoe G; Fuller, Richard A; Dallimer, Martin; Loram, Alison; Gaston, Kevin J

    2012-01-01

    Ameliorating pressures on the ecological condition of the wider landscape outside of protected areas is a key focus of conservation initiatives in the developed world. In highly urbanized nations, domestic gardens can play a significant role in maintaining biodiversity and facilitating human-wildlife interactions, which benefit personal and societal health and well-being. The extent to which sociodemographic and socioeconomic factors are associated with engagement in wildlife gardening activities remain largely unresolved. Using two household-level survey datasets gathered from across Britain, we determine whether and how the socioeconomic background of a household influences participation in food provision for wild birds, the most popular and widespread form of human-wildlife interaction. A majority of households feed birds (64% across rural and urban areas in England, and 53% within five British study cities). House type, household size and the age of the head of the household were all important predictors of bird feeding, whereas gross annual household income, the occupation of the head of the household, and whether the house is owned or rented were not. In both surveys, the prevalence of bird feeding rose as house type became more detached and as the age of the head of the household increased. A clear, consistent pattern between households of varying size was less evident. When regularity of food provision was examined in the study cities, just 29% of households provided food at least once a week. The proportion of households regularly feeding birds was positively related to the age of the head of the household, but declined with gross annual income. As concerns grow about the lack of engagement between people and the natural environment, such findings are important if conservation organizations are successfully to promote public participation in wildlife gardening specifically and environmentally beneficial behaviour in society more generally.

  15. An In-Depth Examination of Perceptions of Physical Activity in Regularly Active and Insufficiently Active Older African American Women: A Participatory Approach

    PubMed Central

    2015-01-01

    Despite considerable research and programmatic efforts to alleviate racial/ethnic disparities in physical activity (PA), disparities in PA among older minorities and major racial ethnic groups persist. This study explored perceptions of PA among regularly active (RA) and insufficiently active (IA) older African American women (AAW) and the factors that influence (positively and negatively) their physical participation in their socio-cultural environment. A total of 20 AAW aged 60 to 80 years participated in a cross-sectional mixed-methods study (i.e., qualitative and quantitative) employing participatory research approaches (i.e., photoelicitation) along with an objective assessment of PA. Nine women were considered RA and 11 IA according to current PA recommendations. RA and IA women held two major beliefs about the nature of PA (i.e., PA as a broadly defined construct that goes beyond traditional exercise routines; and PA and exercise are synonymous and can be used interchangeably) and had a good understanding of its benefits. Participants in both groups did not know about the importance of PA intensity for health benefits. Barriers and facilitator of PA were found to be similar among RA and IA participants. Special attention should be paid to providing access to no or low cost opportunities for PA participation in safe environments. PMID:26554842

  16. An In-Depth Examination of Perceptions of Physical Activity in Regularly Active and Insufficiently Active Older African American Women: A Participatory Approach.

    PubMed

    Sebastião, Emerson; Chodzko-Zajko, Wojtek; Schwingel, Andiara

    2015-01-01

    Despite considerable research and programmatic efforts to alleviate racial/ethnic disparities in physical activity (PA), disparities in PA among older minorities and major racial ethnic groups persist. This study explored perceptions of PA among regularly active (RA) and insufficiently active (IA) older African American women (AAW) and the factors that influence (positively and negatively) their physical participation in their socio-cultural environment. A total of 20 AAW aged 60 to 80 years participated in a cross-sectional mixed-methods study (i.e., qualitative and quantitative) employing participatory research approaches (i.e., photoelicitation) along with an objective assessment of PA. Nine women were considered RA and 11 IA according to current PA recommendations. RA and IA women held two major beliefs about the nature of PA (i.e., PA as a broadly defined construct that goes beyond traditional exercise routines; and PA and exercise are synonymous and can be used interchangeably) and had a good understanding of its benefits. Participants in both groups did not know about the importance of PA intensity for health benefits. Barriers and facilitator of PA were found to be similar among RA and IA participants. Special attention should be paid to providing access to no or low cost opportunities for PA participation in safe environments.

  17. PaR-PaR Laboratory Automation Platform

    SciTech Connect

    Linshiz, G; Stawski, N; Poust, S; Bi, CH; Keasling, JD; Hilson, NJ

    2013-05-01

    Labor-intensive multistep biological tasks, such as the construction and cloning of DNA molecules, are prime candidates for laboratory automation. Flexible and biology-friendly operation of robotic equipment is key to its successful integration in biological laboratories, and the efforts required to operate a robot must be much smaller than the alternative manual lab work. To achieve these goals, a simple high-level biology-friendly robot programming language is needed. We have developed and experimentally validated such a language: Programming a Robot (PaR-PaR). The syntax and compiler for the language are based on computer science principles and a deep understanding of biological workflows. PaR-PaR allows researchers to use liquid-handling robots effectively, enabling experiments that would not have been considered previously. After minimal training, a biologist can independently write complicated protocols for a robot within an hour. Adoption of PaR-PaR as a standard cross-platform language would enable hand-written or software-generated robotic protocols to be shared across laboratories.

  18. PaR-PaR laboratory automation platform.

    PubMed

    Linshiz, Gregory; Stawski, Nina; Poust, Sean; Bi, Changhao; Keasling, Jay D; Hillson, Nathan J

    2013-05-17

    Labor-intensive multistep biological tasks, such as the construction and cloning of DNA molecules, are prime candidates for laboratory automation. Flexible and biology-friendly operation of robotic equipment is key to its successful integration in biological laboratories, and the efforts required to operate a robot must be much smaller than the alternative manual lab work. To achieve these goals, a simple high-level biology-friendly robot programming language is needed. We have developed and experimentally validated such a language: Programming a Robot (PaR-PaR). The syntax and compiler for the language are based on computer science principles and a deep understanding of biological workflows. PaR-PaR allows researchers to use liquid-handling robots effectively, enabling experiments that would not have been considered previously. After minimal training, a biologist can independently write complicated protocols for a robot within an hour. Adoption of PaR-PaR as a standard cross-platform language would enable hand-written or software-generated robotic protocols to be shared across laboratories.

  19. Healthy Cities: facilitating the active participation and empowerment of local people.

    PubMed

    Dooris, Mark; Heritage, Zoe

    2013-10-01

    Community participation and empowerment are key values underpinning the European WHO Healthy Cities initiative, now in its fifth phase. This paper provides a brief overview of the history, policy context, and theory relating to community participation and empowerment. Drawing on Phase IV evaluation data, it presents the findings in relation to the four quadrants of Davidson's Wheel of Participation--information, consultation, participation in decision making, and empowerment. The large majority of European Healthy Cities have mechanisms in place to provide information for and to consult with local people. Most also demonstrate a commitment to enabling community participation in decision-making and to empowering citizens. Within this context, the evaluation highlighted a diversity of approaches and revealed varied perspectives on how participation and empowerment can be integrated within city leadership and governance processes. The paper concludes by suggesting that there is a need to strengthen future evaluative research to better understand how and why the Healthy Cities approach makes a difference.

  20. Interrelation of Sport Participation, Physical Activity, Social Capital and Mental Health in Disadvantaged Communities: A SEM-Analysis

    PubMed Central

    Marlier, Mathieu; Van Dyck, Delfien; Cardon, Greet; De Bourdeaudhuij, Ilse; Babiak, Kathy; Willem, Annick

    2015-01-01

    Background The Health through Sport conceptual model links sport participation with physical, social and psychological outcomes and stresses the need for more understanding between these outcomes. The present study aims to uncover how sport participation, physical activity, social capital and mental health are interrelated by examining these outcomes in one model. Methods A cross-sectional survey was conducted in nine disadvantaged communities in Antwerp (Belgium). Two hundred adults (aged 18–56) per community were randomly selected and visited at home to fill out a questionnaire on socio-demographics, sport participation, physical activity, social capital and mental health. A sample of 414 adults participated in the study. Results Structural Equation Modeling analysis showed that sport participation (β = .095) and not total physical activity (β = .027) was associated with better mental health. No association was found between sport participation and community social capital (β = .009) or individual social capital (β = .045). Furthermore, only community social capital was linked with physical activity (β = .114), individual social capital was not (β = -.013). In contrast, only individual social capital was directly associated with mental health (β = .152), community social capital was not (β = .070). Conclusion This study emphasizes the importance of sport participation and individual social capital to improve mental health in disadvantaged communities. It further gives a unique insight into the functionalities of how sport participation, physical activity, social capital and mental health are interrelated. Implications for policy are that cross-sector initiatives between the sport, social and health sector need to be supported as their outcomes are directly linked to one another. PMID:26451731

  1. Active participation in preventionist professional practices: a specific ergonomics training course.

    PubMed

    Querelle, Léonard; Duwelz, Michel; Beaujouan, Joffrey; Pignault, Anne

    2012-01-01

    Currently, the different forms of corporate management methods (quality circles, lean manufacturing, etc.) are usually based on employee mobilisation. Very often, the goal of this type of approach is at best, to ensure that employees embrace corporate projects, or otherwise to impose changes on them without taking into account the real work and difficulties that they face daily. However, do these employee solicitation methods converge with participatory approaches as envisaged by ergonomists and more generally, preventionists? Based on the observation that the activity of institutional preventionists evolves with regulatory constraints and work related to the monitoring of indicators, the implementation and steering of the participatory approach within companies may be a major lever for prevention. After describing the foundations of a participatory approach, this paper will present a training experiment aimed at implementing and promoting employee participation in prevention efforts. The content of this training is then analysed with regard to the balance between methodology and the use of trainees' narratives. The results of the training session are presented from the point of view of the development prospects for pedagogical tools and the organisation of the training. PMID:22317524

  2. [Mast cell-derived exosome participates in acupoint-stimulation initiated local network activities].

    PubMed

    Chen, Bo; Li, Ming-yue; Guo, Yi; Zhao, Xue; Liu, Yang-yang

    2015-02-01

    The exosome, released from mast cells, T cells, B cells and many other types of cells, is the common form of vesicle transportation between cells and participates in the exchange of information between cells, and may be also involved in acupuncture induced clinical effects. In the present paper, the authors reviewed recent development of researches on this field from 1) acupuncture stimulation induces changes of number and function of mast cells in the local acupoint area, probably being the key factor for initiating acupuncture effect; 2) acupuncture stimulation induces release of neurotransmitters, hormones, cytokines, Ca2+, etc., in the local acupoint region, possibly being closely associated with the production of clinical effects; 3) acupuncture stimulation results in excitation of sensory afferent nerve fibers, triggering neuro-regulation; 4) exosomes derived from mast cells contain multiple neurotransmitters, hormones, cytokines, etc. to activate immune cells and sensory afferent fibers, inducing immuno-regulation and neuro-regulation; and 5) acupuncture stimulation induced release of Ca2+, ATP, etc. may potentiate release and transportation of exosomes. However, current researches are lack of excavation of network connection and transformation from basic research to clinical application. The authors hold that the exosome, released from mast cells by needling acupoints, acts as a messenger in network connection of nerve-mast cell-signal molecule in the body and may be one of the key factors of therapeutic effects.

  3. Active participation in preventionist professional practices: a specific ergonomics training course.

    PubMed

    Querelle, Léonard; Duwelz, Michel; Beaujouan, Joffrey; Pignault, Anne

    2012-01-01

    Currently, the different forms of corporate management methods (quality circles, lean manufacturing, etc.) are usually based on employee mobilisation. Very often, the goal of this type of approach is at best, to ensure that employees embrace corporate projects, or otherwise to impose changes on them without taking into account the real work and difficulties that they face daily. However, do these employee solicitation methods converge with participatory approaches as envisaged by ergonomists and more generally, preventionists? Based on the observation that the activity of institutional preventionists evolves with regulatory constraints and work related to the monitoring of indicators, the implementation and steering of the participatory approach within companies may be a major lever for prevention. After describing the foundations of a participatory approach, this paper will present a training experiment aimed at implementing and promoting employee participation in prevention efforts. The content of this training is then analysed with regard to the balance between methodology and the use of trainees' narratives. The results of the training session are presented from the point of view of the development prospects for pedagogical tools and the organisation of the training.

  4. Community participation in AIDS activities in two pilot areas, Machinga district, Malawi.

    PubMed

    Mwangalawa, A S

    1995-09-01

    Students from the Department of Fine Art and Performing Arts of Chancellor College were subcontracted to spend one month in Nyambi and one month in Gawanani to facilitate participatory research and information gathering from the villages using focus group interviews. Nyambi is an Islamic-dominated area, while Gawanani is Christian-dominated. Music and drama were used to mobilize the communities. Performances were followed by discussion of how traditional practices potentially increasing the community risk of HIV infection could be altered. A drama presentation with proposed solutions was then presented to each community. Major risk factors identified were promiscuity and commercial sex, traditional male circumcision conducted with nonsterile equipment, female initiation requiring young women's participation in sexual intercourse, the sexual cleansing of young widows, tattooing by traditional healers, and misconceptions about how HIV is transmitted. Furthermore, extramarital relationships lead to marital breakdown and the subsequent involvement of unsupervised children in exploratory sexual activities. The district AIDS coordinator facilitated meetings with community leaders to mobilize them to form local AIDS committees. The committees then identified volunteers within their areas who were trained in AIDS education and group discussion skills. 58 volunteers were trained in January 1995. Further plans include the additional training of the volunteers in counseling and home-based care skills, transformation of the volunteers groups into self-administered local nongovernmental organizations, the provision of income-generating activities skills, condom promotion, and the application of the project method in other areas in the district. The success of this project attests to how people, when given the opportunity and guidance, can respond positively to problems and tackle them in their own context.

  5. Localization of Serotoninergic Neurons that Participate in Regulating Diaphragm Activity in the Cat

    PubMed Central

    Rice, Cory D.; Lois, James H.; Kerman, Ilan A.; Yates, Bill J.

    2009-01-01

    Although a considerable body of literature indicates that serotoninergic neurons affect diaphragm activity both through direct inputs to phrenic motoneurons and multisynaptic connections involving the brainstem respiratory groups, the locations of the serotoninergic neurons that modulate breathing have not been well defined. The present study identified these neurons in cats by combining the transneuronal retrograde transport of rabies virus from the diaphragm with the immunohistochemical detection of the N-terminal region of tryptophan hydroxylase-2 (TPH2), the brain-specific isoform of the enzyme responsible for the initial and rate-limiting step in serotonin synthesis. TPH2-immunopositive neurons were present in the midline raphe nuclei, formed a column in the ventrolateral medulla near the lateral reticular nucleus, and were spread across the dorsal portion of the pons just below the fourth ventricle. In most animals, only a small fraction of neurons (typically < 20%) labeled for TPH2 in each of the medullary raphe nuclei and the medullary ventrolateral column were infected with rabies virus. However, the percentage of medullary neurons dual-labeled for both rabies and TPH2 was much higher in animals with very advanced infections where virus had spread transneuronally through many synapses. Furthermore, in all cases, TPH2-immunopositive neurons that were infected by rabies virus were significantly less prevalent in the pons than the medulla. These findings suggest that although serotoninergic neurons with direct influences on diaphragm activity are widely scattered in the brainstem, the majority of these neurons are located in the medulla. Many nonserotoninergic neurons in the raphe nuclei were also infected with rabies virus, indicating that midline cells utilizing multiple neurotransmitters participate in the control of breathing. PMID:19433074

  6. Seahorse-derived peptide suppresses invasive migration of HT1080 fibrosarcoma cells by competing with intracellular α-enolase for plasminogen binding and inhibiting uPA-mediated activation of plasminogen.

    PubMed

    Kim, Yong-Tae; Kim, Se-kwon; Jeon, You-Jin; Park, Sun Joo

    2014-12-01

    α-Enolase is a glycolytic enzyme and a surface receptor for plasminogen. α-Enolase-bound plasminogen promotes tumor cell invasion and cancer metastasis by activating plasmin and consequently degrading the extracellular matrix degradation. Therefore, α-enolase and plasminogen are novel targets for cancer therapy. We found that the amino acid sequence of a peptide purified from enzymatic hydrolysates of seahorse has striking similarities to that of α-enolase. In this study, we report that this peptide competes with cellular α-enolase for plasminogen binding and suppresses urokinase plasminogen activator (uPA)-mediated activation of plasminogen, which results in decreased invasive migration of HT1080 fibrosarcoma cells. In addition, the peptide treatment decreased the expression levels of uPA compared to that of untreated controls. These results provide new insight into the mechanism by which the seahorse-derived peptide suppresses invasive properties of human cancer cells. Our findings suggest that this peptide could emerge as a potential therapeutic agent for cancer.

  7. Extracurricular Activity Participation and the Acquisition of Developmental Assets: Differences between Involved and Noninvolved Canadian High School Students

    ERIC Educational Resources Information Center

    Forneris, Tanya; Camiré, Martin; Williamson, Robert

    2015-01-01

    In order to prepare students for adulthood and responsible citizenship, most high schools offer extracurricular activities designed to facilitate the learning of a wide range of competencies. The purpose of this study was to examine how participation in a single or a combination of extracurricular school activities for high school students may…

  8. Physical Activity and Sports Team Participation: Associations with Academic Outcomes in Middle School and High School Students

    ERIC Educational Resources Information Center

    Fox, Claudia K.; Barr-Anderson, Daheia; Neumark-Sztainer, Dianne; Wall, Melanie

    2010-01-01

    Background: Previous studies have found that higher physical activity levels are associated with greater academic achievement among students. However, it remains unclear whether associations are due to the physical activity itself or sports team participation, which may involve requirements for maintaining certain grades, for example. The purpose…

  9. Active Aging: Exploration into Self-Ratings of "Being Active," Out-of-Home Physical Activity, and Participation among Older Australian Adults Living in Four Different Settings.

    PubMed

    Aird, Rosemary L; Buys, Laurie

    2015-01-01

    We examined whether self-ratings of "being active" among older people living in four different settings (major city high and lower density suburbs, a regional city, and a rural area) were associated with out-of-home participation and outdoor physical activity. A mixed-methods approach (survey, travel diary, and GPS tracking over a one-week period) was used to gather data from 48 individuals aged over 55 years. Self-ratings of "being active" were found to be positively correlated with the number of days older people spent time away from home but unrelated to time traveled by active means (walking and biking). No significant differences in active travel were found between the four study locations, despite differences in their respective built environments. The findings suggest that additional strategies to the creation of "age-friendly" environments are needed if older people are to increase their levels of outdoor physical activity. "Active aging" promotion campaigns may need to explicitly identify the benefits of walking outdoors to ambulatory older people as a means of maintaining their overall health, functional ability, and participation within society in the long-term and also encourage the development of community-based programs in order to facilitate regular walking for this group. PMID:26346381

  10. Pathological VWF fibers resist tPA and ADAMTS13 while promoting the contact pathway and shear-induced platelet activation

    PubMed Central

    Herbig, Bradley A.

    2015-01-01

    Summary Background Under severe stenotic conditions, von Willebrand Factor (VWF) multimerizes into large insoluble fibers at pathological shear rates. Objective Evaluate the mechanics and biology of VWF fibers without the confounding effects of endothelium or collagen. Methods Within a micropost-impingement microfluidic device, >100 µm long VWF fibers multimerized on the post within 10 min using EDTA-treated PFP perfused at wall shear rates >5000 s−1. Results VWF fiber thickness increased to >10 µm by increasing shear rate to 10,000 s−1. In a stress-strain test, fibrous VWF had an elastic modulus of ~50 MPa. The insoluble VWF fibers were non-amyloid since they rapidly dissolved in trypsin, plasmin, or 2% SDS, but were resistant to 50 nM ADAMTS13 or 100 nM tPA in plasma. Following fiber formation, perfusion of low corn trypsin inhibitor (CTI)-treated (4 µg/ml), recalcified citrated plasma at 1500 s−1 caused fibrin formation on the VWF fibers, a result not observed with purified type 1 collagen or a naked micropost. During VWF fiber formation, contact pathway factors accumulated on VWF since the use of EDTA/PPACK/apixaban/high CTI-treated PFP during VWF fiber formation prevented subsequent fibrin production from low CTI, recalcified citrated PFP. VWF fibers displayed FXIIa-immunostaining. When PPACK-inhibited whole blood was perfused over VWF fibers, platelets rolled and arrested on the surface of VWF, but only displayed P-selectin if prevailing shear rates were pathological. Platelet arrest on VWF fibers was blocked with αIIbβ3 antagonist GR144053. Conclusions We report VWF fiber-contact pathway crosstalk and mechanisms of thrombolytic resistance in hemodynamic settings of myocardial infarction. PMID:26178390

  11. Self-efficacy as a mediator of the relationship between perceived union barriers and women's participation in union activities.

    PubMed

    Bulger, C A; Mellor, S

    1997-12-01

    This study investigated the influence of union self-efficacy (expectations of success in pursuit of union activities) as a mediator of the relationship between perceptions of barriers to union participation and women's participation in union activities (N = 89). Perceived barriers were defined in 4 domains (community, family, union, work), and self-efficacy was operationalized based on C. Lee and P. Bobko's (1994) analysis of self-efficacy measures (self-efficacy magnitude, self-efficacy strength). Union self-efficacy was found to mediate the relationship between the magnitude of perceived union barriers and the magnitude of union participation, although mediation was limited to women with weak union self-efficacy. Implications for designing training and intervention programs to enhance women's participation in the face of perceived barriers are discussed.

  12. Participation in Out-of-School Time Activities and Programs. Research Brief. Publication #2014-13

    ERIC Educational Resources Information Center

    Moore, Kristin Anderson; Murphey, David; Bandy, Tawana; Cooper, Mae

    2014-01-01

    Children and youth who participate in out-of-school-time (OST) programming are more likely than their non-participating peers to do well in school, get sufficient physical exercise, and avoid involvement in risky behaviors. However, there are concerns that there are inequities in access to OST programs, particularly for those from lower-income…

  13. Pupils as Active Participants: Diamond Ranking as a Tool to Investigate Pupils' Experiences of Classroom Practices

    ERIC Educational Resources Information Center

    Niemi, Reetta; Kumpulainen, Kristiina; Lipponen, Lasse

    2015-01-01

    This article is based on a pedagogical action research initiative carried out in a Finnish primary school. Twenty-four 5th grade pupils and their teacher participated in the study. The research initiative was guided by two questions: (1) How do pupils experience their classroom practices? (2) How can pupils participate in the process of developing…

  14. Adjustment after Spinal Cord Injury: Relationship to Participation in Employment or Educational Activities.

    ERIC Educational Resources Information Center

    Krause, J. Stuart; Anson, Carol A.

    1997-01-01

    Compares the life adjustment of participants with spinal cord injury (SCI) who were either employed; unemployed, but attending school; or unemployed. Results show that the employed and student participants reported superior adjustment scores compared to the unemployed/nonstudents. Findings reveal the importance of work and education following SCI.…

  15. Socioeconomic status, ethnicity, culture, and immigration: examining the potential mechanisms underlying Mexican-origin adolescents' organized activity participation.

    PubMed

    Simpkins, Sandra D; Delgado, Melissa Y; Price, Chara D; Quach, Alex; Starbuck, Elizabeth

    2013-04-01

    The integrative model for child development and ecodevelopmental theory suggest that macro factors, such as socioeconomic status, ethnicity, culture, and immigration influence the settings in which adolescents engage. The goal of this investigation was to use a combination of deductive and inductive qualitative analysis to describe the mechanisms by which these macro factors might be related to Mexican-origin adolescents' participation in organized after-school activities. Qualitative data were collected through focus group interviews with 44 adolescents, 50 parents, and 18 activity leaders from 2 neighborhoods that varied in ethnic composition and average family income. Results indicated that family socioeconomic status might be related to adolescents' participation through financial resources and parents' work. Ethnicity was identified as a predictor of participation via experiences with ethnic discrimination, particularly in the neighborhood with a low percentage of Hispanic families. Cultural values and practices were related to participants' preferences for particular activities (e.g., bilingual, church-sponsored) and adolescents' participation in activities. Immigration seemed to be a factor in parents' familiarity with and beliefs about organized activities. PMID:22545831

  16. Reliability of ultrasound measurement of automatic activity of the abdominal muscle in participants with and without chronic low back pain

    PubMed Central

    2013-01-01

    Background Ultrasound (US) imaging has been considered as a non-invasive technique to measure thickness and estimate relative abdominal muscle activity. Although some studies have assessed the reliability of US imaging, no study has assessed the reliability of US measurement of automatic activity of abdominal muscles in positions with different levels of stability in participants with chronic low back pain (cLBP). The purpose of this study was to investigate within-day and between-days reliability of US thickness measurements of automatic activity of the abdominal muscles in asymptomatic participants and within-day reliability in those with cLBP. Methods A total of 20 participants (10 with cLBP, 10 healthy) participated in the study. The reliability of US thickness measurements at supine lying and sitting positions (sitting on a chair, sitting on a gym ball with both feet on the ground or lifting one foot off the floor) were assessed. We evaluated within-day reliability in all participants and between-days reliability in asymptomatic participants. Results We found high ICC scores (0.85-0.95) and also small SEM and MDC scores in both groups. The reliability of the measurements was comparable between participants with and without LBP in each position but the SEMs and MDCs was slightly higher in patient group compared with healthy group. It indicates high intra-tester reliability for the US measurement of the thickness of abdominal muscles in all positions. Conclusion US imaging can be used as a reliable method for assessment of automatic activity of abdominal muscles in positions with low levels of stability in participants with and without LBP. PMID:24479859

  17. Reported Sports Participation, Race, Sex, Ethnicity, and Obesity in US Adolescents From NHANES Physical Activity (PAQ_D).

    PubMed

    Turner, Robert W; Perrin, Eliana M; Coyne-Beasley, Tamera; Peterson, Camilla J; Skinner, Asheley C

    2015-01-01

    Objective. To understand the relationships between participation in different types of leisure time sport activity and adolescent obesity, and how those relationships might differ based on race, gender, and household income. Methods. Data consisted of 6667 students that took part in the 1999 to 2006 National Health and Nutrition Examination Survey. The authors used adjusted Wald tests to examine differences in the prevalence of obesity (body mass index >95th percentile for age and sex) by sport for boys and girls separately. Results. Among adolescent youth age 12 to 19 years, 16.6% of male leisure time sport participants and 15.3% of female sport participants were obese, compared with 23.6% for male nonathlete participant-in-other-activities and 17.0% obesity rate for female nonathlete/participant-in-other-activities. For both males and females, reported participation in leisure time sports decreased between middle school and high school, and this reduction was associated with higher body mass index.

  18. Reported Sports Participation, Race, Sex, Ethnicity, and Obesity in US Adolescents From NHANES Physical Activity (PAQ_D)

    PubMed Central

    Perrin, Eliana M.; Coyne-Beasley, Tamera; Peterson, Camilla J.; Skinner, Asheley C.

    2015-01-01

    Objective. To understand the relationships between participation in different types of leisure time sport activity and adolescent obesity, and how those relationships might differ based on race, gender, and household income. Methods. Data consisted of 6667 students that took part in the 1999 to 2006 National Health and Nutrition Examination Survey. The authors used adjusted Wald tests to examine differences in the prevalence of obesity (body mass index >95th percentile for age and sex) by sport for boys and girls separately. Results. Among adolescent youth age 12 to 19 years, 16.6% of male leisure time sport participants and 15.3% of female sport participants were obese, compared with 23.6% for male nonathlete participant-in-other-activities and 17.0% obesity rate for female nonathlete/participant-in-other-activities. For both males and females, reported participation in leisure time sports decreased between middle school and high school, and this reduction was associated with higher body mass index. PMID:27335953

  19. "Because I am Muslim, I cannot wear a swimsuit": Muslim girls negotiate participation opportunities for physical activity.

    PubMed

    Hamzeh, Manal; Oliver, Kimberly L

    2012-06-01

    Drawing on the works of postcolonial critical feminist and Arab Muslim feminist scholars, we discuss in this paper how 4 muslim girls (ages 14- 17 years) negotiated their participation in opportunities for physical activity. Data collection methods included self mapping questionnaires, digital photos, private journal entries, and recordings of informal conversations. We discuss (a) how three discursive challenges emerged in veiling-off opportunities for physical activity, and (b) how the girls uncovered alternative ways of being physically active. To promote active life practices with muslim girls, we need to (a) navigate the diversity of young muslims within the intersecting discourses in their lives that potentially challenge their participation in physical activities, and (b) honor young muslims' choices while negotiating their chances of maintaining physical activities.

  20. "Because I am Muslim, I cannot wear a swimsuit": Muslim girls negotiate participation opportunities for physical activity.

    PubMed

    Hamzeh, Manal; Oliver, Kimberly L

    2012-06-01

    Drawing on the works of postcolonial critical feminist and Arab Muslim feminist scholars, we discuss in this paper how 4 muslim girls (ages 14- 17 years) negotiated their participation in opportunities for physical activity. Data collection methods included self mapping questionnaires, digital photos, private journal entries, and recordings of informal conversations. We discuss (a) how three discursive challenges emerged in veiling-off opportunities for physical activity, and (b) how the girls uncovered alternative ways of being physically active. To promote active life practices with muslim girls, we need to (a) navigate the diversity of young muslims within the intersecting discourses in their lives that potentially challenge their participation in physical activities, and (b) honor young muslims' choices while negotiating their chances of maintaining physical activities. PMID:22808719

  1. Participant adherence indicators predict changes in dietary, physical activity, and clinical outcomes in church-based, diet and supervised physical activity intervention: Delta Body and Soul III

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This secondary analysis evaluated the utility of several participant adherence indicators for predicting health outcome changes in a 6-month, church-based, controlled, lifestyle intervention previously proven effective for improving diet quality, physical activity, and blood lipids. Descriptive ind...

  2. Examination of Children's Recess Physical Activity Patterns Using the Activities for Daily Living-Playground Participation (ADL-PP) Instrument

    ERIC Educational Resources Information Center

    Stellino, Megan Babkes; Sinclair, Christina

    2014-01-01

    Thorough assessment of children's physical activity is essential to efficacious interventions to reduce childhood obesity prevalence. The purpose of this study was to examine children's recess physical activity (RPA) patterns of behavior using the Activities of Daily Living-Playground Participation (ADL-PP: Watkinson et al., 2001)…

  3. 4,6-Diphenylpyridines as Promising Novel Anti-Influenza Agents Targeting the PA-PB1 Protein-Protein Interaction: Structure-Activity Relationships Exploration with the Aid of Molecular Modeling.

    PubMed

    Trist, Iuni M L; Nannetti, Giulio; Tintori, Cristina; Fallacara, Anna Lucia; Deodato, Davide; Mercorelli, Beatrice; Palù, Giorgio; Wijtmans, Maikel; Gospodova, Tzveta; Edink, Ewald; Verheij, Mark; de Esch, Iwan; Viteva, Lilia; Loregian, Arianna; Botta, Maurizio

    2016-03-24

    Influenza is an infectious disease that represents an important public health burden, with high impact on the global morbidity, mortality, and economy. The poor protection and the need of annual updating of the anti-influenza vaccine, added to the rapid emergence of viral strains resistant to current therapy make the need for antiviral drugs with novel mechanisms of action compelling. In this regard, the viral RNA polymerase is an attractive target that allows the design of selective compounds with reduced risk of resistance. In previous studies we showed that the inhibition of the polymerase acidic protein-basic protein 1 (PA-PB1) interaction is a promising strategy for the development of anti-influenza agents. Starting from the previously identified 3-cyano-4,6-diphenyl-pyridines, we chemically modified this scaffold and explored its structure-activity relationships. Noncytotoxic compounds with both the ability of disrupting the PA-PB1 interaction and antiviral activity were identified, and their mechanism of target binding was clarified with molecular modeling simulations. PMID:26924568

  4. The association between active participation in a sports club, physical activity and social network on the development of lung cancer in smokers: a case-control study

    PubMed Central

    2012-01-01

    Background This study analyses the effect of active participation in a sports club, physical activity and social networks on the development of lung cancer in patients who smoke. Our hypothesis is that study participants who lack social networks and do not actively participate in a sports club are at a greater risk for lung cancer than those who do. Methods Data for the study were taken from the Cologne Smoking Study (CoSmoS), a retrospective case-control study examining potential psychosocial risk factors for the development of lung cancer. Our sample consisted of n = 158 participants who had suffered lung cancer (diagnosis in the patient document) and n = 144 control group participants. Both groups had a history of smoking. Data on social networks were collected by asking participants whether they participated in a sports club and about the number of friends and relatives in their social environment. In addition, sociodemographic data (gender, age, education, marital status, residence and religion), physical activity and data on pack years (the cumulative number of cigarettes smoked by an individual, calculated by multiplying the number of cigarettes smoked per day by the number of years the person has smoked divided by 20) were collected to control for potential confounders. Logistic regression was used for the statistical analysis. Results The results reveal that participants who are physically active are at a lower risk of lung cancer than those who are not (adjusted OR = 0.53*; CI = 0.29-0.97). Older age and lower education seem also to be risk factors for the development of lung cancer. The extent of smoking, furthermore, measured by pack years is statistically significant. Active participation in a sports club, number of friends and relatives had no statistically significant influence on the development of the cancer. Conclusions The results of the study suggest that there is a lower risk for physically active participants to develop lung cancer. In the

  5. Recommendations for participation in competitive sport and leisure-time physical activity in individuals with cardiomyopathies, myocarditis and pericarditis.

    PubMed

    Pelliccia, Antonio; Corrado, Domenico; Bjørnstad, Hans Halvor; Panhuyzen-Goedkoop, Nicole; Urhausen, Axel; Carre, Francois; Anastasakis, Aris; Vanhees, Luc; Arbustini, Eloisa; Priori, Silvia

    2006-12-01

    Several relatively uncommon, but important cardiovascular diseases are associated with increased risk for acute cardiac events during exercise (including sudden death), such as hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), arrhythmogenic right ventricular cardiomyopathy (ARVC) and myo-pericarditis. Practising cardiologists are frequently asked to advise on exercise programmes and sport participation in young individuals with these cardiovascular diseases. Indeed, many asymptomatic (or mildly symptomatic) patients with cardiomyopathies aspire to a physically active lifestyle to take advantage of the many documented benefits of exercise. While recommendations dictating the participation in competitive sport for athletes with cardiomyopathies and myo-pericarditis have recently been published as a consensus document of the European Society of Cardiology, no European guidelines have addressed the possible participation of patients with cardiomyopathies in recreational and amateur sport activities. The present document is intended to offer a comprehensive overview to practising cardiologists and sport physicians of the recommendations governing safe participation in different types of competitive sport, as well as the participation in a variety of recreational physical activities and amateur sports in individuals with cardiomyopathies and myo-pericarditis. These recommendations, based largely on the experience and insights of the expert panel appointed by the European Society of Cardiology, include the most up-to-date information concerning regular exercise and sports activity in patients with cardiomyopathies and myo-pericarditis. PMID:17143118

  6. 77 FR 32087 - Agency Information Collection Activities; Proposed Collection; Comment Request; Participation by...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-31

    ... Disadvantaged Business Enterprises in Procurement Under Environmental Protection Agency (EPA) Financial...: Participation by Disadvantaged Business Enterprises in Procurement under EPA Financial Assistance Agreements... requires an entity to be certified in order to be considered a Minority Business Enterprise (MBE) or...

  7. Associations of participation in service activities with academic, behavioral, and civic outcomes of adolescents at varying risk levels.

    PubMed

    Schmidt, Jennifer A; Shumow, Lee; Kackar, Hayal Z

    2012-07-01

    Youth who participate in service activities differ from those who do not on a number of key demographic characteristics like socio-economic status and other indicators of risk; and most studies demonstrating positive outcomes among service participants employ small non-representative samples. Thus, there is little evidence as to whether the outcomes associated with service participation are similar among students with varying levels of risk. The National Household Education Survey of 1999, a large nationally representative cross-sectional data set that focused on community service, was analyzed to investigate associations between the risk status of 4,306 adolescent students (50.2% female; 63.3% European American, M age = 15.9), their participation in community service, and their academic adjustment, behavioral problems, and civic knowledge. Because adolescents who participate in service differ from those who do not with respect to demographic characteristics, propensity score analyses were used to correct for potential selection bias in the examination of these relationships. Analyses tested competing theoretical models of service-protective versus compensatory-among students at varying levels of risk, and suggested that service acts as a compensatory factor with respect to academic, behavioral, and civic outcomes. Propensity score analyses revealed patterns suggesting that, in some cases, students with certain demographic profiles that are themselves related to the likelihood of service participation may benefit from service participation more than others. Findings are discussed in terms of their significance for adolescent development, for planning service programs, and for educational policy.

  8. Alcohol-related and alcohol-free activity participation and enjoyment among college students: a behavioral theories of choice analysis.

    PubMed

    Murphy, James G; Barnett, Nancy P; Colby, Suzanne M

    2006-08-01

    College student alcohol abuse remains a significant public health problem, and there is a need for theory-driven and empirically based models to guide prevention efforts. Behavioral theories of choice assume that the decision to consume alcohol is influenced by the relative value of alcohol versus other available activities. In the present study, a sample of college student drinkers (N=108; 56% female, 44% male) who had previously completed a mandatory alcohol intervention completed a measure of alcohol-related and alcohol-free activity participation and enjoyment. The goals of the study were to examine the influence of drinking quantity and contextual variables on activity enjoyment and to identify enjoyable alcohol-free activities that take place on evenings when students might otherwise be drinking. Overall, students found alcohol-related activities more enjoyable than alcohol-free activities, and drinking quantity was positively related to enjoyment. However, alcohol-free activities such as watching movies, going to the theater or museums, going to bars or parties, hanging out with friends, eating at restaurants, and engaging in creative activity were generally as enjoyable as drinking. Alcohol-free activities that included peers or dates were more enjoyable than solitary activities. Men were less likely to engage in alcohol-free activities that included peers and reported less enjoyment related to alcohol-free activities than did women. Further research is required to identify procedures for increasing participation in alcohol-free activities and to determine whether increased alcohol-free activity participation results in decreased alcohol consumption. PMID:16893277

  9. Motivation and Physical Activity Behaviors among Older Women: A Self-Determination Perspective

    ERIC Educational Resources Information Center

    Stephan, Yannick; Boiche, Julie; Le Scanff, Christine

    2010-01-01

    Drawing upon Self-Determination Theory, the purpose of our study was to examine the motivational determinants of older women's dropout and participation in physical activity (PA). Older women who dropped out (n = 242) or remained (n = 332) in an organized PA program completed the Sport Motivation Scale as well as health and PA measures. We found…

  10. Mediated Effects of Perceived Competence on Youth Physical Activity and Sedentary Behavior

    ERIC Educational Resources Information Center

    Bai, Yang; Chen, Senlin; Vazou, Spyridoula; Welk, Gregory J.; Schaben, Jodee

    2015-01-01

    Purpose: This study evaluates whether physical activity (PA) and sedentary behavior (SB) are influenced by a common mediating relationship. Method: A total of 1,552 participants in 3rd to 12th grade completed an online survey that included assessments of PA at school (PAS), PA at home (PAH), and SB as well as a battery of psychosocial variables…

  11. Social Cognitive Factors Associated with Physical Activity in Elementary School Girls

    ERIC Educational Resources Information Center

    Bean, Melanie K.; Miller, Sara; Mazzeo, Suzanne E.; Fries, Elizabeth A.

    2012-01-01

    Objective: To examine social cognitive factors associated with physical activity (PA) among preadolescent girls. Method: Social cognitive theory was used to examine PA in girls (N = 90; 71% African American) participating in Girls on the Run. Multiple regressions explored factors associated with PA at posttesting and 3-month follow-up. Results:…

  12. Physical Activity Behavior, Barriers to Activity, and Opinions About a Smartphone-Based Physical Activity Intervention Among Rural Residents

    PubMed Central

    Logan, Henrietta; Manini, Todd; Dallery, Jesse

    2015-01-01

    Abstract Background: Rural Americans engage in less physical activity (PA) and experience higher rates of consequent health problems (i.e., obesity, cardiovascular disease) than urban Americans. Although geographic barriers have historically made this population hard to reach, rural individuals are increasingly gaining access to smartphones. Thus, the purpose of this study was to evaluate PA behavior and barriers to PA among rural residents and to gauge their receptiveness to a smartphone-based PA intervention that is currently in the development stage. Materials and Methods: Rural Floridian adults (n=113), 18 years of age and older, completed surveys to assess PA behavior, PA barriers, and opinions about an intervention to increase PA. Specifically, they were asked to imagine a program that would require them to do PA with their mobile phones and whether they viewed intended aspects of the program as helpful. The present work is therefore formative research that sought to determine the feasibility and acceptability of a smartphone-based intervention among rural residents. Results of the survey will inform the development of a tailored, smartphone-based PA intervention. Results: The 37.2% of participants with low PA levels (<600 metabolic equivalent [MET]-min per week) were more likely to report personal and environmental barriers to PA than the 47.8% of participants with moderate PA levels (≥600 MET-min per week). More barriers were reported among participants who self-reported as white and among participants of older age, lower education level, and lower socioeconomic status. Additionally, 75.9% of participants reported features of the intervention as at least somewhat helpful. Conclusions: The growing ubiquity of smartphones among rural residents, combined with participants' positive response to the program description, supports the acceptability of a smartphone-based PA intervention for rural communities. Given the participants' receptiveness, future research

  13. Influences of personality traits and continuation intentions on physical activity participation within the theory of planned behaviour.

    PubMed

    Chatzisarantis, Nikos L D; Hagger, Martin S

    2008-01-01

    Previous research has suggested that the theory of planned behaviour is insufficient in capturing all the antecedents of physical activity participation and that continuation intentions or personality traits may improve the predictive validity of the model. The present study examined the combined effects of continuation intentions and personality traits on health behaviour within the theory of planned behaviour. To examine these effects, 180 university students (N = 180, Male = 87, Female = 93, Age = 19.14 years, SD = 0.94) completed self-report measures of the theory of planned behaviour, personality traits and continuation intentions. After 5 weeks, perceived achievement of behavioural outcomes and actual participation in physical activities were assessed. Results supported discriminant validity between continuation intentions, conscientiousness and extroversion and indicated that perceived achievement of behavioural outcomes and continuation intentions of failure predicted physical activity participation after controlling for personality effects, past behaviour and other variables in the theory of planned behaviour. In addition, results indicated that conscientiousness moderated the effects of continuation intentions of failure on physical activity such that continuation intentions of failure predicted physical activity participation among conscientious and not among less conscientious individuals. These findings suggest that the effects of continuation intentions on health behaviour are contingent on personality characteristics.

  14. Tag team simulation: An innovative approach for promoting active engagement of participants and observers during group simulations.

    PubMed

    Levett-Jones, Tracy; Andersen, Patrea; Reid-Searl, Kerry; Guinea, Stephen; McAllister, Margaret; Lapkin, Samuel; Palmer, Lorinda; Niddrie, Marian

    2015-09-01

    Active participation in immersive simulation experiences can result in technical and non-technical skill enhancement. However, when simulations are conducted in large groups, maintaining the interest of observers so that they do not disengage from the learning experience can be challenging. We implemented Tag Team Simulation with the aim of ensuring that both participants and observers had active and integral roles in the simulation. In this paper we outline the features of this innovative approach and provide an example of its application to a pain simulation. Evaluation was conducted using the Satisfaction with Simulation Experience Scale. A total of 444 year nursing students participated from a population of 536 (response rate 83%). Cronbach's alpha for the Scale was .94 indicating high internal consistency. The mean satisfaction score for participants was 4.63 compared to 4.56 for observers. An independent sample t test revealed no significant difference between these scores (t (300) = -1.414, p = 0.16). Tag team simulation is an effective approach for ensuring observers' and participants' active involvement during group-based simulations and one that is highly regarded by students. It has the potential for broad applicability across a range of leaning domains both within and beyond nursing. PMID:25936431

  15. Boys, Transitions, and Physical (In)activity: Exploring the Socio-Behavioural Mediators of Participation.

    PubMed

    Jachyra, Patrick; Gibson, Barbara E

    2016-01-01

    Objet: Explorer les mécanismes sociocomportementaux qui poussent les garçons à faire de l'activité physique (AP) ou les en dissuade à l'aube de l'adolescence et les répercussions sur le plan de la physiothérapie. Méthodes: Cette étude qualitative critique comportait des entrevues en profondeur basées sur des techniques de « l'entrevue active » de 15 garçons adolescents. La génération et l'analyse des données ont été propulsées par les techniques de la théorie à base empirique et la sociologie de la pratique de Bourdieu. Résultats: L'analyse a dégagé des relations intersectionnelles entre les émotions, les plaisirs inhérents au mouvement et un sentiment de lien avec l'AP, dont chacune a agi comme facteur de motivation incitant à faire de l'AP. De façon analogue, l'insatisfaction à l'égard de leur corps, des perceptions de soi négatives et des cas répétés d'intimidation explicite et symbolique ont convergé pour dissuader de faire de l'AP et susciter de l'apathie à cet égard. Conclusion: La détermination de mécanismes sociocomportementaux qui motivent et découragent l'activité physique aide à produire de nouvelles connaissances qui aident à comprendre l'attrition de l'AP chez les garçons à l'aube de l'adolescence. En tant que promoteurs de la santé et experts du mouvement, les physiothérapeutes ont un rôle important à jouer en aidant les adolescents, sans égard à leurs aptitudes, à participer à des activités qui leur donnent un sens, de l'inclusivité et un sentiment de lien avec l'AP.

  16. Differences in behavior, psychological factors, and environmental factors associated with participation in school sports and other activities in adolescence.

    PubMed

    Harrison, Patricia A; Narayan, Gopalakrishnan

    2003-03-01

    This study examined whether participation in school team sports, exclusively or in combination with other extracurricular activities, is associated with higher levels of psychosocial functioning and healthy behavior than participation in other extracurricular activities alone or nonparticipation. The study sample includes 50,168 ninth grade public school students who completed an anonymous, voluntary statewide survey in 2001. Students were classified into four groups based on their participation in sports and other activities (such as clubs, volunteer work, band, choir, or music lessons): neither, both, other activities only, and sports only. Odds ratios for the group involved in both types of activities were significantly higher than those for all the other groups for all healthy behaviors and measures of connectedness, and significantly lower for all but one of the unhealthy behaviors. Students involved in sports, alone or in combination with other activities, had significantly higher odds than the other two groups for exercise, milk consumption, and healthy self-image, and significantly lower odds for emotional distress, suicidal behavior, family substance abuse, and physical and sexual abuse victimization. Students involved in other activities, alone or in combination with sports, had significantly higher odds than the other two groups for doing homework and significantly lower odds for alcohol consumption, marijuana use, and vandalism. The finding that abuse victims appeared to avoid sports but not other group activities raises concern and merits further research. Considering the potential benefits of participation in sports and other activities, more research is needed to identify and overcome barriers or deterrents, particularly for youth from low-income families.

  17. Differences in behavior, psychological factors, and environmental factors associated with participation in school sports and other activities in adolescence.

    PubMed

    Harrison, Patricia A; Narayan, Gopalakrishnan

    2003-03-01

    This study examined whether participation in school team sports, exclusively or in combination with other extracurricular activities, is associated with higher levels of psychosocial functioning and healthy behavior than participation in other extracurricular activities alone or nonparticipation. The study sample includes 50,168 ninth grade public school students who completed an anonymous, voluntary statewide survey in 2001. Students were classified into four groups based on their participation in sports and other activities (such as clubs, volunteer work, band, choir, or music lessons): neither, both, other activities only, and sports only. Odds ratios for the group involved in both types of activities were significantly higher than those for all the other groups for all healthy behaviors and measures of connectedness, and significantly lower for all but one of the unhealthy behaviors. Students involved in sports, alone or in combination with other activities, had significantly higher odds than the other two groups for exercise, milk consumption, and healthy self-image, and significantly lower odds for emotional distress, suicidal behavior, family substance abuse, and physical and sexual abuse victimization. Students involved in other activities, alone or in combination with sports, had significantly higher odds than the other two groups for doing homework and significantly lower odds for alcohol consumption, marijuana use, and vandalism. The finding that abuse victims appeared to avoid sports but not other group activities raises concern and merits further research. Considering the potential benefits of participation in sports and other activities, more research is needed to identify and overcome barriers or deterrents, particularly for youth from low-income families. PMID:12677730

  18. Neighbourhood green space, physical function and participation in physical activities among elderly men: the Caerphilly Prospective study

    PubMed Central

    2014-01-01

    Background The built environment in which older people live plays an important role in promoting or inhibiting physical activity. Most work on this complex relationship between physical activity and the environment has excluded people with reduced physical function or ignored the difference between groups with different levels of physical function. This study aims to explore the role of neighbourhood green space in determining levels of participation in physical activity among elderly men with different levels of lower extremity physical function. Method Using data collected from the Caerphilly Prospective Study (CaPS) and green space data collected from high resolution Landmap true colour aerial photography, we first investigated the effect of the quantity of neighbourhood green space and the variation in neighbourhood vegetation on participation in physical activity for 1,010 men aged 66 and over in Caerphilly county borough, Wales, UK. Second, we explored whether neighbourhood green space affects groups with different levels of lower extremity physical function in different ways. Results Increasing percentage of green space within a 400 meters radius buffer around the home was significantly associated with more participation in physical activity after adjusting for lower extremity physical function, psychological distress, general health, car ownership, age group, marital status, social class, education level and other environmental factors (OR = 1.21, 95% CI 1.05, 1.41). A statistically significant interaction between the variation in neighbourhood vegetation and lower extremity physical function was observed (OR = 1.92, 95% CI 1.12, 3.28). Conclusion Elderly men living in neighbourhoods with more green space have higher levels of participation in regular physical activity. The association between variation in neighbourhood vegetation and regular physical activity varied according to lower extremity physical function. Subjects reporting poor lower extremity

  19. Less Socially Engaged? Participation in Friendship and Extracurricular Activities Among Racial/Ethnic Minority and Immigrant Adolescents

    ERIC Educational Resources Information Center

    Cherng, Hua-Yu Sebastian; Turney, Kristin; Kao, Grace

    2014-01-01

    Background/Context: Prior research has linked social engagement, such as peer interaction and participation in school activities, to a host of positive outcomes for youth and adolescents. However, little research considers patterns of social engagement among racial/ethnic minority and immigrant adolescents, despite prior research suggesting…

  20. Effects of Participation in High School Sports and Nonsport Extracurricular Activities on Political Engagement among Black Young Adults

    ERIC Educational Resources Information Center

    Braddock, Jomills Henry; Hua, Lv; Dawkins, Marvin P.

    2007-01-01

    The impact of involvement in high school athletics and nonsport extracurricular activities on political engagement among young Black adults was examined. We developed a conceptual model to identify school engagement factors and assess their influence on political participation (i.e., voter registration and voting behavior) of Blacks in early…

  1. The Over-Scheduling Hypothesis Revisited: Intensity of Organized Activity Participation during Adolescence and Young Adult Outcomes

    ERIC Educational Resources Information Center

    Mahoney, Joseph L.; Vest, Andrea E.

    2012-01-01

    Concern exists that youth who spend a lot of time participating in organized out-of-school activities (e.g., sports) are at-risk for poor developmental outcomes. This concern--called the over-scheduling hypothesis--has primarily been assessed in terms of adolescent adjustment. This longitudinal study of a nationally representative sample of 1,115…

  2. Student Teachers' Beliefs about Learning and Teaching and Their Participation in Career-Long Learning Activities

    ERIC Educational Resources Information Center

    de Vries, Siebrich; Jansen, Ellen P. W. A.; Helms-Lorenz, Michelle; van de Grift, Wim J. C. M.

    2014-01-01

    Career-long teacher learning is essential to the teaching profession because it is strongly connected with teacher quality and practices. Student teachers in the first stage of their career-long learning continuum, however, vary in the extent to which they participate in learning activities. This study explores the relationship between beliefs…

  3. Negotiating Participation and Power in a School Setting: The Implementation of Active Citizenship within the Undergraduate Sociology Curriculum

    ERIC Educational Resources Information Center

    Gifford, Chris; Watt, Paul; Clark, Wayne; Koster, Shirley

    2005-01-01

    Since the Crick Report, active citizenship has been promoted as a vehicle for enhancing community involvement and political literacy among school and higher education students. This ostensibly progressive educational and social goal is beset with a number of tensions and contradictions, notably around the nature of participation and between…

  4. Group Dynamics in the Language Classroom: Embodied Participation as Active Reception in the Collective Zone of Proximal Development

    ERIC Educational Resources Information Center

    van Compernolle, Rémi A.; Williams, Lawrence

    2013-01-01

    This article explores the notion of "active reception" during small-group collaborative interaction in the foreign language classroom, focusing on the embodied participation of a secondary (nonspeaking) interactant, Diane. Drawing on Vygotskian sociocultural theory, we argue that within small-group work, a Zone of Proximal Development…

  5. The Impact of Media Sport Events on the Active Participation of Young People and Some Implications for PE Pedagogy

    ERIC Educational Resources Information Center

    Lines, Gill

    2007-01-01

    This article addresses the impact of selected sports media events on the active participation of a group of young people aged 14/15. Its particular focus is on an intense period of media sport coverage during the European Soccer Championships (Euro '96), the Wimbledon Lawn Tennis Championships and the Atlanta Olympics and on how a group of British…

  6. Understanding EFL Students' Participation in Group Peer Feedback of L2 Writing: A Case Study from an Activity Theory Perspective

    ERIC Educational Resources Information Center

    Yu, Shulin; Lee, Icy

    2015-01-01

    While the last three decades have witnessed a growing body of research on peer feedback in first language (L1) and second language (L2) writing, research about students' motives for participating in group peer feedback has remained underexplored. In order to fill this important gap, this case study, guided by the constructs of activity and motive…

  7. Women Empowerment and Participation in Economic Activities: Indispensable Tools for Self-Reliance and Development of Nigerian Society

    ERIC Educational Resources Information Center

    E. N., Ekesionye; A. N., Okolo

    2012-01-01

    The objective of the study was to examine women empowerment and participation in economic activities as tools for self-reliance and development of the Nigerian society. Research questions and hypothesis were used to guide the study. Structured questionnaire was used as the major instrument for data collection. Copies of questionnaires were…

  8. 5 CFR 734.502 - Participation in political activity while on duty, in uniform, in any room or building occupied...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Office of the President § 734.502 Participation in political activity while on duty, in uniform, in any... appropriation for the Executive Office of President; or (ii) An employee appointed by the President by and with... of the Vice President which are part of the Residence area or which are not regularly used solely...

  9. 5 CFR 734.502 - Participation in political activity while on duty, in uniform, in any room or building occupied...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Office of the President § 734.502 Participation in political activity while on duty, in uniform, in any... appropriation for the Executive Office of President; or (ii) An employee appointed by the President by and with... of the Vice President which are part of the Residence area or which are not regularly used solely...

  10. 5 CFR 734.502 - Participation in political activity while on duty, in uniform, in any room or building occupied...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Office of the President § 734.502 Participation in political activity while on duty, in uniform, in any... appropriation for the Executive Office of President; or (ii) An employee appointed by the President by and with... of the Vice President which are part of the Residence area or which are not regularly used solely...

  11. 5 CFR 734.502 - Participation in political activity while on duty, in uniform, in any room or building occupied...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Office of the President § 734.502 Participation in political activity while on duty, in uniform, in any... appropriation for the Executive Office of President; or (ii) An employee appointed by the President by and with... of the Vice President which are part of the Residence area or which are not regularly used solely...

  12. 5 CFR 734.502 - Participation in political activity while on duty, in uniform, in any room or building occupied...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Office of the President § 734.502 Participation in political activity while on duty, in uniform, in any... appropriation for the Executive Office of President; or (ii) An employee appointed by the President by and with... of the Vice President which are part of the Residence area or which are not regularly used solely...

  13. Participation in Extracurricular Activities in the Middle School Years: Are There Developmental Benefits for African American and European American Youth?

    ERIC Educational Resources Information Center

    Fredricks, Jennifer A.; Eccles, Jacquelynne S.

    2008-01-01

    In this study, we examined the associations between organized activity participation during early adolescence and adjustment in a large and economically diverse sample of African American and European American youth. The sample included 1,047 youth (51% female and 49% male and 67% African American and 33% European American). We used analysis of…

  14. Local Ownership of Education Policies at the Crossroads between the Active Participation and the Passive Compliance to International Goals

    ERIC Educational Resources Information Center

    Imaniriho, Dan

    2015-01-01

    Over the past three decades, perceptions about the role of local population in policy development process have deeply changed. This change is related to the idea promoted by international institutions that the development actions cannot succeed without a strong local ownership and a broad approach that guarantee active participation of local…

  15. "Because I Am Muslim, I Cannot Wear a Swimsuit:" Muslim Girls Negotiate Participation Opportunities for Physical Activity

    ERIC Educational Resources Information Center

    Hamzeh, Manal; Oliver, Kimberly L.

    2012-01-01

    Drawing on the works of postcolonial critical feminist and Arab Muslim feminist scholars, we discuss in this paper how 4 Muslim girls (ages 14-17 years) negotiated their participation in opportunities for physical activity. Data collection methods included self-mapping questionnaires, digital photos, private journal entries, and recordings of…

  16. Participation in Activities outside of School Hours in Relation to Problem Behavior and Social Skills in Middle Childhood

    ERIC Educational Resources Information Center

    Howie, LaJeana D.; Lukacs, Susan L.; Pastor, Patricia N.; Reuben, Cynthia A.; Mendola, Pauline

    2010-01-01

    Background: Research has shown that participating in activities outside of school hours is associated with lower dropout rates, enhanced school performance, improved social skills, and reduced problem behaviors. However, most prior studies have been limited to small populations of older children (greater than 12 years). This analysis focuses on…

  17. COMPARISON OF EXERCISE PARTICIPATION RATES FOR CHILDREN IN THE LITERATURE WITH THOSE IN EPA'S CONSOLIDATED HUMAN ACTIVITY DATABASE (CHAD)

    EPA Science Inventory

    CHAD contains over 22,000 person-days of human activity pattern survey data. Part of the database includes exercise participation rates for children 0-17 years old, as well as for adults. Analyses of this database indicates that approximately 34% of the 0-17 age group (herea...

  18. 7 CFR 621.41 - Participation in Federal-State policy and planning activities at the regional level.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... activities at the regional level. 621.41 Section 621.41 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE WATER RESOURCES RIVER BASIN INVESTIGATIONS AND SURVEYS Interagency Coordination § 621.41 Participation in...

  19. 7 CFR 621.41 - Participation in Federal-State policy and planning activities at the regional level.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... activities at the regional level. 621.41 Section 621.41 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE WATER RESOURCES RIVER BASIN INVESTIGATIONS AND SURVEYS Interagency Coordination § 621.41 Participation in...

  20. 7 CFR 621.41 - Participation in Federal-State policy and planning activities at the regional level.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... activities at the regional level. 621.41 Section 621.41 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE WATER RESOURCES RIVER BASIN INVESTIGATIONS AND SURVEYS Interagency Coordination § 621.41 Participation in...

  1. The Contribution of Executive Functions to Participation in School Activities of Children with High Functioning Autism Spectrum Disorder

    ERIC Educational Resources Information Center

    Zingerevich, Chaya; Patricia D., LaVesser

    2009-01-01

    This study describes the contribution of executive functions to participation in school activities of children diagnosed with ASD ages 6-9 years while controlling for sensory processing. Twenty-four children, ages 73-112 months (S.D. = 11.4), diagnosed with high functioning ASD were assessed with the Wisconsin Card Sorting Test. Their teachers…

  2. 20 CFR 667.274 - What health and safety standards apply to the working conditions of participants in activities...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false What health and safety standards apply to the...' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR ADMINISTRATIVE PROVISIONS UNDER TITLE... and safety standards apply to the working conditions of participants in activities under title I...

  3. 20 CFR 667.274 - What health and safety standards apply to the working conditions of participants in activities...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false What health and safety standards apply to the...' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR ADMINISTRATIVE PROVISIONS UNDER TITLE... and safety standards apply to the working conditions of participants in activities under title I...

  4. Onset of Smoking Behaviors and Participation in Leisure Physical Activities of Turkish Adolescents Attending Vocational Health Schools

    ERIC Educational Resources Information Center

    Subasi, Feryal; Hey, William; Mumcu, Gonca; Koksal, Leyla; Luleci, Emel; Sur, Haydar

    2006-01-01

    This cross-sectional study was conducted with the aim of examining the relationships between smoking behavior and leisure physical activity habits of adolescents (n=170, 85F & 85M, mean age= 15.42 [plus or minus] 0.58, age range=15-17 years) attending vocational health schools in Turkey. Participants were randomly selected from four provinces of…

  5. Warm-Up Activities of Middle and High School Band Directors Participating in State-Level Concert Band Assessments

    ERIC Educational Resources Information Center

    Ward, Justin P.; Hancock, Carl B.

    2016-01-01

    The purpose of this study was to examine the warm-ups chosen by concert band directors participating in state-level performance assessments. We observed 29 middle and high school bands and coded the frequency and duration of warm-up activities and behaviors. Results indicated that most bands rehearsed music and played scales, long tones, and…

  6. Implications of Rural Environmental Variables Associated with the Participation of Children in Farming Activities: A Lesson from Rural Southwestern Nigeria

    ERIC Educational Resources Information Center

    Ajayi, A. O.; Jibowo, A. A.

    2006-01-01

    This study aimed at investigating the relationship between the participation of rural children in farming activities and selected social, school, and physical environment related variables. Data were collected from four hundred and fifty eight children selected through stage-wise random sampling procedure from the four agricultural zones in Oyo…

  7. Effects of an intervention based on self-determination theory on self-reported leisure-time physical activity participation.

    PubMed

    Chatzisarantis, Nikos L D; Hagger, Martin S

    2009-01-01

    Based on self-determination theory, the present study developed and evaluated the utility a school-based intervention to change pupils' physical activity intentions and self-reported leisure-time physical activity behaviour. The study evaluated utility of the intervention to promote physical activity participation over a 5-week interval of time. A cluster randomised design targeting 215 pupils from 10 schools with schools as the unit of randomisation was adopted (Male = 106, Female = 109, Age = 14.84, SD = 0.48). Results indicated that pupils who were taught by autonomy-supportive teachers reported stronger intentions to exercise during leisure time and participated more frequently in leisure-time physical activities than pupils in the control condition. Autonomous motivation and intentions mediated the effects of the intervention on self-reported physical activity behaviour. It is concluded that self-determination theory provides a useful framework for the development of school-based interventions that ultimately affect leisure-time physical activity participation.

  8. Participation in the Virtual Environment of Blended College Courses: An Activity Study of Student Performance

    ERIC Educational Resources Information Center

    Cavanaugh, Cathy; Hargis, Jace; Mayberry, John

    2016-01-01

    This paper describes a study of success factors in the introductory semester of liberal studies blended courses offered at the bachelor of science level. The influence of student participation in the online course environment was examined, as measured by the number of times students logged into the learning management system (LMS) and average…

  9. Sibling Influence on Physical Activity and Sport Participation: Considerations for Coaches

    ERIC Educational Resources Information Center

    Allbaugh, Chelsea N.; Bolter, Nicole D.; Shimon, Jane M.

    2016-01-01

    Sibling relationships are some of the most influential throughout one's life. While family influences have often been examined in sports settings, less has been studied regarding the specific roles siblings may play. Research suggests that the way athletes view sport participation can be shaped by their experiences and relationships with siblings.…

  10. Using a Peer-Mediated Intervention To Facilitate Children's Participation in Inclusive Childcare Activities.

    ERIC Educational Resources Information Center

    Robertson, Jo; Green, Kim; Alper, Sandra; Schloss, Patrick J.; Kohler, Frank

    2003-01-01

    A study examined the impact of a peer-mediated intervention consisting of songs and finger plays, attention to photographs of desired behavior, and peer verbal cues, on two preschoolers with developmental delays. The intervention resulted in increases in engaged and on-task behavior, interactive play, and appropriate participation in circle/story…

  11. Professional Student Organizations and Experiential Learning Activities: What Drives Student Intentions to Participate?

    ERIC Educational Resources Information Center

    Munoz, Laura; Miller, Richard; Poole, Sonja Martin

    2016-01-01

    Experiential learning theory has been referenced as a possible method for attracting and retaining members in student organizations. In a survey, undergraduate students evaluated a variety of organizational features pertaining to their intention to participate in professional student organizations. The study found that students value activities…

  12. Political Activities of Social Workers: Addressing Perceived Barriers to Political Participation

    ERIC Educational Resources Information Center

    Rocha, Cynthia; Poe, Bethanie; Thomas, Veliska

    2010-01-01

    This article reviews the literature on political participation of social workers and the variables that promote or impede political advocacy. Early research in the 1980s and 1990s most often reported education, feelings of efficacy, having a macro-type job, and being a member of a national association as factors that determine greater political…

  13. Three Worlds: New Directions in Participant Development in Sport and Physical Activity

    ERIC Educational Resources Information Center

    Collins, Dave; Bailey, Richard; Ford, Paul A.; MacNamara, Aine; Toms, Martin; Pearce, Gemma

    2012-01-01

    The twin challenges of inactivity and the 2012 Olympics have tightened the focus in UK sport promotion. However, the twin track approach which treats these challenges as distinct concerns may limit the efficacy of interventions in either area. We propose that a continuum between participation, performance sport and elite achievement represents the…

  14. Exploring the Lived Experiences of Participants in Simulation-Based Learning Activities

    ERIC Educational Resources Information Center

    Beard, Rachael

    2013-01-01

    There is currently a small body of research on the experiences of participants, both facilitators and learners, during simulated mock codes (cardiac arrest) in the healthcare setting. This study was based on a practitioner's concerns that mock codes are facilitated differently among educators, mock codes are not aligned with andragogy theory of…

  15. OXIDATIVE STRESS PARTICIPATES IN ACUTE LUNG INJURY AND ACTIVATION OF MITOGEN ACTIVATED PROTEIN KINASES (MAPK) FOLLOWING AIR POLLUTION PARTICLE EXPOSURE (PM)

    EPA Science Inventory

    OXIDATIVE STRESS PARTICIPATES IN ACUTE LUNG INJURY AND ACTIVATION OF MITOGEN ACTIVATED PROTEIN KINASES (MAPK) FOLLOWING AIR POLLUTION PARTICLE EXPOSURE (PM). E S Roberts1, R Jaskot2, J Richards2, and K L Dreher2. 1College of Veterinary Medicine, NC State University, Raleigh, NC a...

  16. College Students' Motivation for Physical Activity: Differentiating Men's and Women's Motives for Sport Participation and Exercise

    ERIC Educational Resources Information Center

    Kilpatrick, Marcus; Hebert, Edward; Bartholomew, John

    2005-01-01

    Despite the many clear benefits of an active lifestyle, lack of physical activity is a significant health problem in the college population. A key issue in physical activity research is developing an understanding of motivation. Although physical activity takes many forms, most research designed to enhance motivation for and adherence to physical…

  17. Comments on "Female Participation in Housing Activities: Some Assessment of the Socio-economic and Cultural Impact.

    PubMed

    Kazi, S

    1992-01-01

    Critical comments are provided on a study of Pakistani women's participation in housing activities from a financial, physical, and decision-making viewpoint. It is highlighted that the multivariate analysis focused only on financial and physical participation. The statistical analysis is considered flawed, because factors such as age and the relationship of the woman to the head of the household were not included. As a consequence there is no distinction between an elderly mother-in-law's or a young unmarried girl's contribution to housing participation. Another criticism is the use of a dummy variable for employment rather than specification of type of employment. Prior research suggests that type of employment is the critical determinant of women's participation. A woman's control over decision making is expected to differ in households where women are engaged in agricultural production rather than in the market economy. Those women working in the informal economy are different from women working in the formal sector. Literacy as a dummy variable obscures the effects of levels of educational status. The analysis also lacks a firm explanation for why Baluchistan is positive and significant in explaining women's financial participation in housing. Balochi women tend to have low status in terms of employment and education. The expectation is that household income and number of adult women would be negatively related to physical participation in housing, rather than insignificantly related. Another shortcoming is the lack of attention to the extent of women's involvement in housing activities and a description of the socioeconomic characteristics of respondents. The most important omission is the failure to focus on women's involvement in decision making and the identification of factors that influence women's participation in decision making. PMID:12286750

  18. Does Spinal Fusion and Scoliosis Correction Improve Activity and Participation for Children With GMFCS level 4 and 5 Cerebral Palsy?

    PubMed

    Sewell, Mathew David; Wallace, Charlie; Malagelada, Francesc; Gibson, Alex; Noordeen, Hilali; Tucker, Stewart; Molloy, Sean; Lehovsky, Jan

    2015-12-01

    Spinal fusion is used to treat scoliosis in children with cerebral palsy (CP). Following intervention, the WHO considers activity and participation should be assessed to guide intervention and assess the effects. This study assesses whether spinal fusion for scoliosis improves activity and participation for children with severe CP.Retrospective cohort study of 70 children (39M:31F) with GMFCS level 4/5 CP and significant scoliosis. Thirty-six underwent observational and/or brace treatment as the sole treatment for their scoliosis, and 34 underwent surgery. Children in the operative group were older and had worse scoliosis than those in the observational group. Questionnaire and radiographic data were recorded over a 2-year period. The ASKp was used to measure activity and participation.In the observational group, Cobb angle and pelvic obliquity increased from 51 (40-90) and 10 (0-30) to 70 (43-111) and 14 (0-37). Mean ASKp decreased from 16.3 (1-38) to 14.2 (1-36). In the operative group, Cobb angle and pelvic obliquity decreased from 81 (50-131) and 14 (1-35) to 38 (10-76) and 9 (0-24). Mean ASKp increased from 10.5 (0-29) to 15.9 (3-38). Spinal-related pain correlated most with change in activity and participation in both groups. There was no difference in mobility, GMFCS level, feeding or communication in either group before and after treatment.In children with significant scoliosis and CP classified within GMFCS levels 4 and 5, spinal fusion was associated with an improvement in activity and participation, whereas nonoperative treatment was associated with a small reduction. Pain should be carefully assessed to guide intervention.

  19. Does Spinal Fusion and Scoliosis Correction Improve Activity and Participation for Children With GMFCS level 4 and 5 Cerebral Palsy?

    PubMed Central

    Sewell, Mathew David; Wallace, Charlie; Malagelada, Francesc; Gibson, Alex; Noordeen, Hilali; Tucker, Stewart; Molloy, Sean; Lehovsky, Jan

    2015-01-01

    Abstract Spinal fusion is used to treat scoliosis in children with cerebral palsy (CP). Following intervention, the WHO considers activity and participation should be assessed to guide intervention and assess the effects. This study assesses whether spinal fusion for scoliosis improves activity and participation for children with severe CP. Retrospective cohort study of 70 children (39M:31F) with GMFCS level 4/5 CP and significant scoliosis. Thirty-six underwent observational and/or brace treatment as the sole treatment for their scoliosis, and 34 underwent surgery. Children in the operative group were older and had worse scoliosis than those in the observational group. Questionnaire and radiographic data were recorded over a 2-year period. The ASKp was used to measure activity and participation. In the observational group, Cobb angle and pelvic obliquity increased from 51o (40–90) and 10o (0–30) to 70o (43–111) and 14o (0–37). Mean ASKp decreased from 16.3 (1–38) to 14.2 (1–36). In the operative group, Cobb angle and pelvic obliquity decreased from 81o (50–131) and 14o (1–35) to 38o (10–76) and 9o (0–24). Mean ASKp increased from 10.5 (0–29) to 15.9 (3–38). Spinal-related pain correlated most with change in activity and participation in both groups. There was no difference in mobility, GMFCS level, feeding or communication in either group before and after treatment. In children with significant scoliosis and CP classified within GMFCS levels 4 and 5, spinal fusion was associated with an improvement in activity and participation, whereas nonoperative treatment was associated with a small reduction. Pain should be carefully assessed to guide intervention. PMID:26656322

  20. Relationship of stride activity and participation in mobility-based life habits among children with cerebral palsy

    PubMed Central

    Bjornson, Kristie F.; Zhou, Chuan; Stevenson, Richard D.; Christakis, Dimitri

    2014-01-01

    Objective To date walking outcomes in cerebral palsy (CP) have been capacity-based (what a child does in structured setting). Physical activity performance (what a child really does in daily life) has been documented to influence the relationship of capacity-based gross motor measures to participation.(1) This study examines the relationship between walking performance and participation in mobility-related habits of daily life in children with CP. Design Cross-sectional prospective cohort study. Setting Regional pediatric specialty care centers Participants A cohort of 128 ambulatory children with CP ages 2–9 yrs, 41% female, and 49% having hemiplegia participated. Interventions Not Applicable. Main Outcome Measures Walking performance was quantified from a 5-day sample of StepWatch accelerometry data. Stride activity was summarized through the outcomes of average total strides/day (independent of intensity) and average number of strides/day at > 30 strides/minute (marker of intensity). Mobility-based participation was assessed by the Life Habits (Life-H) categories of Personal Care, Housing, Mobility, and Recreation. Regression models were developed controlling for gender, age, cognition, communication, pain, and body composition. Results Average total strides/day was positively associated with the Personal Care, Housing, Mobility, and Recreation Life-H categories (β = .34 to.41, p <.001). Average number of strides > 30 stride/min/day was associated with all categories (β = .54 to.60, p < .001). Conclusions Accelerometry-based walking activity performance is significantly associated with levels of participation in mobility-based life habits for ambulatory children with CP. Evaluation of other factors and the direction of relationships within the ICF is warranted to inform rehabilitation strategies. PMID:24231402

  1. Perceptions of barriers and facilitators in physical activity participation among women in Thiruvananthapuram City, India

    PubMed Central

    Mathews, Elezebeth; Lakshmi, J. K.; Sundari Ravindran, T. K.; Pratt, Michael; Thankappan, K. R.

    2015-01-01

    Background Despite the known benefits of physical activity, very few people, especially women, are found to engage in regular physical activity. This study explored the perceptions, barriers and facilitators related to physical activity among women in Thiruvananthapuram City, India. Methods Four focus group discussions were conducted among individuals between 25 and 60 years of age, in a few areas of Thiruvananthapuram City Corporation limits in Kerala, preparatory to the design of a physical activity intervention trial. An open-ended approach was used and emergent findings were analyzed and interpreted. Results Women associated physical activity mostly with household activities. The majority of the women considered their activity level adequate, although they engaged in what the researchers concluded were quite low levels of activity. Commonly reported barriers were lack of time, motivation, and interest; stray dogs; narrow roads; and not being used to the culture of walking. Facilitators of activity were seeing others walking, walking in pairs, and pleasant walking routes. Walking was reported as the most feasible physical activity by women. Conclusion Physical activity promotion strategies among women should address the prevailing cultural norms in the community, and involve social norming and overcoming cultural barriers. They should also target the modifiable determinants of physical activity, such as improving self-efficacy, improving knowledge on the adequacy of physical activity and its recommendations, facilitating goal-setting, and enhancing social support through peer support and group-based activities. PMID:25829405

  2. CicLAvia: Evaluation of participation, physical activity and cost of an open streets event in Los Angeles.

    PubMed

    Cohen, Deborah; Han, Bing; Derose, Kathryn P; Williamson, Stephanie; Paley, Aaron; Batteate, Christina

    2016-09-01

    Physical activity is beneficial for health, but there are limited opportunities in urban areas to safely access public streets for traffic-free cycling, skating or walking. Ciclovías are open streets programs that close major roads to motor vehicles so they can be exclusively used by bicyclists and pedestrians. We estimated participation in one Los Angeles Ciclovía event (CicLAvia) using intercept surveys and 14 surveillance cameras which were placed along the 6-mile route in April 2014. We also applied estimates of the distance and speed traveled from the use of GPS data acquired from subsequent CicLAvia events. CicLAvia attracted between 37,700 and 53,950 active participants generating 176,500 to 263,000 MET-hours of energy expenditure, at an estimated cost borne by tax dollars of $1.29 to $1.91 per MET-hour. Among participants, 37% had never previously participated in CicLAvia, but 40% of individuals said that if they were not at CicLAvia they would have been physically active elsewhere and 45% would have been sedentary. Given its large reach, it makes sense to increase the frequency of Ciclovías to occur more than a few times a year to promote population health. PMID:27317978

  3. Technical Insights for Saltstone PA Maintenance

    SciTech Connect

    Flach, G.; Sarkar, S.; Mahadevan, S.; Kosson, D.

    2011-07-20

    compatibility with existing CBP expertise and already-planned activities. Based on these criteria, the five original topics were down-selected to two: external sulfate attack and mechanistic geochemical prediction. For each of the selected topics, the CBP communicated with the PA analysts and subject matter experts at Savannah River to acquire input data specific to the Saltstone facility and related laboratory experiments. Simulations and analyses were performed for both topics using STADIUM (SIMCO 2008), LeachXS/ORCHESTRA (ECN 2007, Meeussen 2003), and other software tools. These supplemental CBP analyses produced valuable technical insights that can be used to strengthen the Saltstone PA using the ongoing PA maintenance process. This report in part summarizes key information gleaned from more comprehensive documents prepared by Sarkar et al. (2010), Samson (2010), and Sarkar (2010).

  4. Preschooler's Physical Activity Levels and Associations with Lesson Context, Teacher's Behavior, and Environment during Preschool Physical Education

    ERIC Educational Resources Information Center

    Van Cauwenberghe, Eveline; Labarque, Valery; Gubbels, Jessica; De Bourdeaudhuij, Ilse; Cardon, Greet

    2012-01-01

    Preschools offer two main opportunities, recess and physical education (PE), for preschool children to participate in physical activity (PA) and are considered a suitable institution for PA promotion given the large number of children enrolled. Although PE can have a meaningful effect on preschoolers' PA levels, preschool PE characteristics…

  5. Participation in Physical, Social, and Religious Activity and Risk of Depression in the Elderly: A Community-Based Three-Year Longitudinal Study in Korea

    PubMed Central

    Roh, Hyun Woong; Hong, Chang Hyung; Lee, Yunhwan; Oh, Byoung Hoon; Lee, Kang Soo; Chang, Ki Jung; Kang, Dae Ryong; Kim, Jinhee; Lee, SooJin; Back, Joung Hwan; Chung, Young Ki; Lim, Ki Young; Noh, Jai Sung; Kim, Dongsoo; Son, Sang Joon

    2015-01-01

    Background We examined the longitudinal association between participation in individual or combinations of physical, social, and religious activity and risk of depression in the elderly. Methods Elderly subjects aged ≥60 years who completed the Living Profiles of Older People Survey in Korea (n = 6,647) were included. The baseline assessment, Wave 1, was conducted in 2008, and a follow-up assessment, Wave 2, was conducted in 2011. We defined participation in frequent physical activity as ≥3 times weekly (at least 30 minutes per activity). Frequent participation in social and religious activity was defined as ≥1 activity weekly. The primary outcome was depression at 3-year follow up. Results Multivariable logistic regression analysis showed that subjects who participated in frequent physical, social, and religious activity had an adjusted odds ratio of 0.81 (95% confidence interval [CI], 0.69–0.96), 0.87 (95% CI, 0.75–1.00), and 0.78 (95% CI, 0.67–0.90), respectively, compared with participants who did not participate in each activity. Participants who participated in only one type of activity frequently and participants who participated in two or three types of activities frequently had an adjusted odds ratio of 0.86 (95% CI, 0.75–0.98) and 0.64 (95% CI, 0.52–0.79), respectively, compared with participants who did not participate in any type of physical, social, and religious activity frequently. Conclusion Participation in physical, social, and religious activity was associated with decreased risk of depression in the elderly. In addition, risk of depression was much lower in the elderly people who participated in two or three of the above-mentioned types of activity than that in the elderly who did not. PMID:26172441

  6. High t-PA release by neonate brain microvascular endothelial cells under glutamate exposure affects neuronal fate.

    PubMed

    Henry, Vincent Jean; Lecointre, Maryline; Laudenbach, Vincent; Ali, Carine; Macrez, Richard; Jullienne, Amandine; Berezowski, Vincent; Carmeliet, Peter; Vivien, Denis; Marret, Stéphane; Gonzalez, Bruno José; Leroux, Philippe

    2013-02-01

    Glutamate excitotoxicity is a consolidated hypothesis in neonatal brain injuries and tissue plasminogen activator (t-PA) participates in the processes through proteolytic and receptor mediated effects. In brain microvascular endothelial cell (nBMEC) cultures from neonates, t-PA content and release upon glutamate are higher than in adult (aBMECs) cultures. Owing to the variety of t-PA substrates and receptor targets, the study was aimed at determining the putative roles of endothelial t-PA in the neonatal brain parenchyma under glutamate challenge. Basal t-PA release was 4.4 fold higher in nBMECs vs aBMECs and glutamate was 20 fold more potent to allow Evans blue vascular permeability in neonate microvessels indicating that, under noxious glutamate (50 μM) exposure, high amounts of endothelial t-PA stores may be mobilized and may access the nervous parenchyma. Culture media from nBMECS or aBMECs challenged by excitotoxic glutamate were applied to neuron cultures at DIV 11. While media from adult cells did not evoke more LDH release in neuronal cultures that under glutamate alone, media from nBMECs enhanced 2.2 fold LDH release. This effect was not observed with media from t-PA(-/-) nBMECs and was inhibited by hr-PAI-1. In Cortical slices from 10 day-old mice, hrt-PA associated with glutamate evoked neuronal necrosis in deeper (more mature) layers, an effect reversed by NMDA receptor GluN1 amino-terminal domain antibody capable of inhibiting t-PA potentiation of the receptor. In superficial layers (less mature), hrt-PA alone inhibited apoptosis, an effect reversed by the EGF receptor antagonist AG1478. Applied to immature neurons in culture (DIV5), media from nBMEC rescued 85.1% of neurons from cell death induced by serum deprivation. In cortical slices, the anti-apoptotic effect of t-PA fitted with age dependent localization of less mature neurons. These data suggest that in the immature brain, propensity of vessels to release high amounts of t-PA may not only

  7. Extracurricular activities: Investigating the affects of participation-nonparticipation on the Georgia High School Science Graduation Test

    NASA Astrophysics Data System (ADS)

    Moran, Ray A.

    Student achievement research suggests that participation in extracurricular activities has a positive impact on the academic and developmental outcomes for adolescents. Specifically, several studies reported that adolescents who participate in extra-curricular activities are more likely to experience increases in academic achievement, self-esteem, high school graduation rates, and pro-social behaviors. On the other hand, there is research suggesting that participation in extracurricular activities may distract students from their academic pursuits. The state of Georgia requires all eleventh grade students to participate in the Georgia High School Graduation Test (GHSGT). The GHSGT consists of five separate tests that include (a) English/language arts, (b) math, (c) writing, (d) social studies, and (e) science. Each comprehensive exam is worth 600 points. A high school diploma will be awarded if the student scores at least 500 points on each individual exam. Further, review of student outcomes on the GHSGT revealed that first-time test takers were failing the science portion of the test at a greater percentage than any other subject on the GHSGT. Specifically, the Governor's Office of Student Achievement (GOSA) reported that from 2002 through 2004, a total of 70,451 students or 30.3% of students that were first-time test takers failed the science portion of the GHSGT. As a result, investigating factors that potentially could increase student achievement in science became the impetus for this study. In particular, this study examined the relationships between the levels of student participation in school sponsored extracurricular activities in relation to the level of student achievement in the area of science.

  8. Automated Analysis of e-Participation Data by Utilizing Associative Networks, Spreading Activation and Unsupervised Learning

    NASA Astrophysics Data System (ADS)

    Teufl, Peter; Payer, Udo; Parycek, Peter

    According to [1], the term e-participation is defined as ”the use of information and communication technologies to broaden and deepen political participation by enabling citizens to connect with one another and with their elected representatives”. This definition sounds quite simple and logical, but when considering the implementation of such a service in a real world scenario, it is obvious that it is not possible to evaluate messages, which are generated by thousands of citizens, by hand. Such documents need to be read and analyzed by experts with the required in-depth domain knowledge. In order to enable this analysis process and thereby to increase the number of possible e-particpation applications, we need to provide these experts with automated analysis tools that cluster, pre-screen and pre-evaluate public opinions and public contributions. In this paper we present a framework based on Machine Learning-(ML) and Artificial Intelligence-(AI) techniques that are capable of various analysis mechanisms such as unsupervised clustering of yet unread documents, searching for related concepts within documents and the description of relations between terms. To finish, we show how the proposed framework can be applied to real world data taken from the Austrian e-participation platform mitmachen.at.

  9. Student Constructions of "Active Citizenship": What Does Participation Mean to Students?

    ERIC Educational Resources Information Center

    Kennedy, Kerry J.

    2007-01-01

    "Active citizenship" is currently a popular term in citizenship education policy discourse. Despite this policy interest, there is no agreement about the meaning of "active citizenship". This article draws on data from the IEA Civic Education Study to explore how students themselves construct "active citizenship". The results show that students…

  10. Developing Long-Term Physical Activity Participation: A Grounded Theory Study with African American Women

    ERIC Educational Resources Information Center

    Harley, Amy E.; Buckworth, Janet; Katz, Mira L.; Willis, Sharla K.; Odoms-Young, Angela; Heaney, Catherine A.

    2009-01-01

    Regular physical activity is linked to a reduced risk of obesity and chronic disease. African American women bear a disproportionate burden from these conditions and many do not get the recommended amount of physical activity. Long-term success of interventions to initiate and maintain a physically active lifestyle among African American women has…

  11. An Examination of Triple Jeopardy in Rural Youth Physical Activity Participation

    ERIC Educational Resources Information Center

    Shores, Kindal A.; Moore, Justin B.; Yin, Zenong

    2010-01-01

    Purpose: Chances for a healthy life are not equally distributed across society. Instead, genetic, social, and environmental factors help determine the probability that a child will be healthy and active. We investigate the probability that youth will be physically active by examining 3 consistent correlates of physical activity. The individual and…

  12. Atomic structure of anthrax PA pore elucidates toxin translocation

    PubMed Central

    Jiang, Jiansen; Pentelute, Bradley L.; Collier, R. John; Zhou, Z. Hong

    2015-01-01

    Summary Anthrax toxin, comprising protective antigen (PA), lethal factor (LF) and edema factor (EF), is the major virulence factor of Bacillus anthracis, an agent that causes high mortality in human and animals. PA forms oligomeric prepores that undergo conversion to membrane-spanning pores by endosomal acidification, and these pores translocate the enzymes LF and EF into the cytosol of target cells1. PA is not only a vaccine component and therapeutic target for anthrax infections but also an excellent model system for understanding the mechanism of protein translocation. Based on biochemical and electrophysiological results, researchers have proposed that a Φ-clamp composed of Phe427 residues of PA catalyzes protein translocation via a charge-state dependent Brownian ratchet2–9. Although atomic structures of PA prepores are available10–14, how PA senses low pH, converts to active pore and translocates LF and EF are not well defined without an atomic model of the PA pore. Here, by cryo electron microscopy (cryoEM) with direct electron counting, we have determined the PA pore structure at 2.9-Å resolution. The structure reveals the long-sought-after catalytic Φ-clamp and the membrane-spanning translocation channel, and supports the Brownian ratchet model for protein translocation. Comparisons of four structures reveal conformational changes in prepore to pore conversion that support a multi-step mechanism by which low-pH is sensed and the membrane-spanning channel is formed. PMID:25778700

  13. Anti-listeria activity of poly(lactic acid)/sawdust particle biocomposite film impregnated with pediocin PA-1/AcH and its use in raw sliced pork.

    PubMed

    Woraprayote, Weerapong; Kingcha, Yutthana; Amonphanpokin, Pannawit; Kruenate, Jittiporn; Zendo, Takeshi; Sonomoto, Kenji; Benjakul, Soottawat; Visessanguan, Wonnop

    2013-10-15

    A novel poly(lactic acid) (PLA)/sawdust particle (SP) biocomposite film with anti-listeria activity was developed by incorporation of pediocin PA-1/AcH (Ped) using diffusion coating method. Sawdust particle played an important role in embedding pediocin into the hydrophobic PLA film. The anti-listeria activity of the PLA/SP biocomposite film incorporated with Ped (PLA/SP+Ped) was detected, while no activity against the tested pathogen was observed for the control PLA films (without SP and/or Ped). Dry-heat treatment of film before coating with Ped resulted in the highest Ped adsorption (11.63 ± 3.07 μg protein/cm(2)) and the highest anti-listeria activity. A model study of PLA/SP+Ped as a food-contact antimicrobial packaging on raw sliced pork suggests a potential inhibition of Listeria monocytogenes (99% of total listerial population) on raw sliced pork during the chilled storage. This study supports the feasibility of using PLA/SP+Ped film to reduce the initial load of L. monocytogenes on the surface of raw pork.

  14. Elucidating Protactinium Hydrolysis: The Relative Stabilities of PaO2(H2O)(+) and PaO(OH)2(+).

    PubMed

    Dau, Phuong D; Wilson, Richard E; Gibson, John K

    2015-08-01

    It is demonstrated that the gas-phase oxo-exchange of PaO2(+) with water is substantially faster than that of UO2(+), indicating that the Pa-O bonds are more susceptible to activation and formation of the bis-hydroxide intermediate, PaO(OH)2(+). To elucidate the nature of the water adduct of PaO2(+), hydration of PaO2(+) and UO2(+), as well as collision induced dissociation (CID) and ligand-exchange of the water adducts of PaO2(+) and UO2(+), was studied. The results indicate that, in contrast to UO2(H2O)(+), the protactinium oxo bis-hydroxide isomer, PaO(OH)2(+), is produced as a gas-phase species close in energy to the hydrate isomer, PaO2(H2O)(+). CID behavior similar to that of Th(OH)3(+) supports the assignment as PaO(OH)2(+). The gas-phase results are consistent with the spontaneous hydrolysis of PaO2(+) in aqueous solution, this in contrast to later AnO2(+) (An = U, Np, Pu), which forms stable hydrates in both solution and gas phase. In view of the known propensity for Th(IV) to hydrolyze, and previous gas-phase studies of other AnO2(+), it is concluded that the stabilities of oxo-hydroxides relative to oxide hydrates decreases in the order: Th(IV) > Pa(V) > U(V) > Np(V) > Pu(V). This trend suggests increasing covalency and decreasing ionicity of An-O bonds upon proceeding across the actinide series.

  15. Elucidating Protactinium Hydrolysis: The Relative Stabilities of PaO2(H2O)(+) and PaO(OH)2(+).

    PubMed

    Dau, Phuong D; Wilson, Richard E; Gibson, John K

    2015-08-01

    It is demonstrated that the gas-phase oxo-exchange of PaO2(+) with water is substantially faster than that of UO2(+), indicating that the Pa-O bonds are more susceptible to activation and formation of the bis-hydroxide intermediate, PaO(OH)2(+). To elucidate the nature of the water adduct of PaO2(+), hydration of PaO2(+) and UO2(+), as well as collision induced dissociation (CID) and ligand-exchange of the water adducts of PaO2(+) and UO2(+), was studied. The results indicate that, in contrast to UO2(H2O)(+), the protactinium oxo bis-hydroxide isomer, PaO(OH)2(+), is produced as a gas-phase species close in energy to the hydrate isomer, PaO2(H2O)(+). CID behavior similar to that of Th(OH)3(+) supports the assignment as PaO(OH)2(+). The gas-phase results are consistent with the spontaneous hydrolysis of PaO2(+) in aqueous solution, this in contrast to later AnO2(+) (An = U, Np, Pu), which forms stable hydrates in both solution and gas phase. In view of the known propensity for Th(IV) to hydrolyze, and previous gas-phase studies of other AnO2(+), it is concluded that the stabilities of oxo-hydroxides relative to oxide hydrates decreases in the order: Th(IV) > Pa(V) > U(V) > Np(V) > Pu(V). This trend suggests increasing covalency and decreasing ionicity of An-O bonds upon proceeding across the actinide series. PMID:26203499

  16. Why older people engage in physical activity: an exploratory study of participants in a community-based walking program.

    PubMed

    Capalb, Darren J; O'Halloran, Paul; Liamputtong, Pranee

    2014-01-01

    While older people experience substantial physical and mental health benefits from regular physical activity, participation rates among older people are low. There is a need to gather more information about why older people do and do not engage in physical activity. This paper aims to examine the reasons why older men and women chose to engage in a community-based physical activity program. Specific issues that were examined included reasons why older people who had been involved in a community-based program on a regular basis: commenced the program; continued with the program; and recommenced the program after they had dropped out. Ten participants (eight females and two males) aged between 62 and 75 years, who had been participating in a community-based physical activity program for a minimum of 6 months, were individually interviewed. Thematic analysis was used to analyse the data. Three major themes emerged, including 'time to bond: social interaction' with sub-themes 'bona fide friendships' and 'freedom from being isolated'; 'I want to be healthy: chronic disease management'; and 'new lease on life'. Two of the primary reasons why older people both commenced and recommenced the program were the promise of social interaction and to be able to better manage their chronic conditions. PMID:23241196

  17. Children's Physical Activity Behavior during School Recess: A Pilot Study Using GPS, Accelerometer, Participant Observation, and Go-Along Interview.

    PubMed

    Pawlowski, Charlotte Skau; Andersen, Henriette Bondo; Troelsen, Jens; Schipperijn, Jasper

    2016-01-01

    Schoolyards are recognized as important settings for physical activity interventions during recess. However, varying results have been reported. This pilot study was conducted to gain in-depth knowledge of children's physical activity behavior during recess using a mixed-methods approach combining quantitative GPS and accelerometer measurements with qualitative go-along group interviews and participant observations. Data were collected during three weekdays in a public school in Denmark. Eighty-one children (47 girls) wore an accelerometer (ActiGraph GT3X) and GPS (QStarz BT-Q1000xt), sixteen children participated in go-along group interviews, and recess behavior was observed using an ethnographical participant observation approach. All data were analyzed separated systematically answering the Five W Questions. Children were categorized into Low, Middle and High physical activity groups and these groups were predominantly staying in three different locations during recess: school building, schoolyard and field, respectively. Mostly girls were in the building remaining in there because of a perceived lack of attractive outdoor play facilities. The children in the schoolyard were predominantly girls who preferred the schoolyard over the field to avoid the competitive soccer games on the field whereas boys dominated the field playing soccer. Using a mixed-methods approach to investigate children's physical activity behavior during recess helped gain in-depth knowledge that can aid development of future interventions in the school environment.

  18. Children's Physical Activity Behavior during School Recess: A Pilot Study Using GPS, Accelerometer, Participant Observation, and Go-Along Interview.

    PubMed

    Pawlowski, Charlotte Skau; Andersen, Henriette Bondo; Troelsen, Jens; Schipperijn, Jasper

    2016-01-01

    Schoolyards are recognized as important settings for physical activity interventions during recess. However, varying results have been reported. This pilot study was conducted to gain in-depth knowledge of children's physical activity behavior during recess using a mixed-methods approach combining quantitative GPS and accelerometer measurements with qualitative go-along group interviews and participant observations. Data were collected during three weekdays in a public school in Denmark. Eighty-one children (47 girls) wore an accelerometer (ActiGraph GT3X) and GPS (QStarz BT-Q1000xt), sixteen children participated in go-along group interviews, and recess behavior was observed using an ethnographical participant observation approach. All data were analyzed separated systematically answering the Five W Questions. Children were categorized into Low, Middle and High physical activity groups and these groups were predominantly staying in three different locations during recess: school building, schoolyard and field, respectively. Mostly girls were in the building remaining in there because of a perceived lack of attractive outdoor play facilities. The children in the schoolyard were predominantly girls who preferred the schoolyard over the field to avoid the competitive soccer games on the field whereas boys dominated the field playing soccer. Using a mixed-methods approach to investigate children's physical activity behavior during recess helped gain in-depth knowledge that can aid development of future interventions in the school environment. PMID:26859288

  19. The influence of physical activity on alcohol consumption among heavy drinkers participating in an alcohol treatment intervention.

    PubMed

    Kendzor, Darla E; Dubbert, Patricia M; Olivier, Jake; Businelle, Michael S; Grothe, Karen B

    2008-10-01

    Researchers have hypothesized that physical activity may be beneficial for individuals attempting to reduce their alcohol consumption, although few studies have actually tested this relationship. The purpose of the present study was to describe the physical activity of 620 male veterans enrolled in a treatment intervention study for heavy drinkers, and to determine whether greater involvement in physical activity was associated with greater reductions in alcohol consumption. Participants endorsed moderate physical activity at the baseline visit (median=1.65 kcal/kg/day expended from physical activity), although physical activity declined during over time, p=.011. The most frequently endorsed activities included walking, gardening/yardwork, calisthenics, biking, swimming, weight lifting, golfing, and dancing. Regression analyses revealed no significant relationships between energy expenditure from physical activity and reductions in alcohol consumption at the six- and 12-month visits. Findings suggest that engaging in physical activity does not enhance treatment outcomes within interventions that do not specifically aim to increase physical activity. However, commonly endorsed activities may be easily incorporated into interventions in which physical activity is a desired component. PMID:18639987

  20. Women's weekend in ninth year. PinnacleHealth, Harrisburg, PA.

    PubMed

    Herreria, J

    1997-01-01

    For nine years, PinnacleHealth has lured busy women in the Harrisburg, Pa., area away for a weekend of pampering. It's a project of PinnacleHealth's WomanCare's Resource Center. The program began with 239 women, last year the event drew 400 participants. PMID:10174494