Science.gov

Sample records for activity page features

  1. Social Bookmarking Induced Active Page Ranking

    NASA Astrophysics Data System (ADS)

    Takahashi, Tsubasa; Kitagawa, Hiroyuki; Watanabe, Keita

    Social bookmarking services have recently made it possible for us to register and share our own bookmarks on the web and are attracting attention. The services let us get structured data: (URL, Username, Timestamp, Tag Set). And these data represent user interest in web pages. The number of bookmarks is a barometer of web page value. Some web pages have many bookmarks, but most of those bookmarks may have been posted far in the past. Therefore, even if a web page has many bookmarks, their value is not guaranteed. If most of the bookmarks are very old, the page may be obsolete. In this paper, by focusing on the timestamp sequence of social bookmarkings on web pages, we model their activation levels representing current values. Further, we improve our previously proposed ranking method for web search by introducing the activation level concept. Finally, through experiments, we show effectiveness of the proposed ranking method.

  2. An Ant Colony Optimization Based Feature Selection for Web Page Classification

    PubMed Central

    2014-01-01

    The increased popularity of the web has caused the inclusion of huge amount of information to the web, and as a result of this explosive information growth, automated web page classification systems are needed to improve search engines' performance. Web pages have a large number of features such as HTML/XML tags, URLs, hyperlinks, and text contents that should be considered during an automated classification process. The aim of this study is to reduce the number of features to be used to improve runtime and accuracy of the classification of web pages. In this study, we used an ant colony optimization (ACO) algorithm to select the best features, and then we applied the well-known C4.5, naive Bayes, and k nearest neighbor classifiers to assign class labels to web pages. We used the WebKB and Conference datasets in our experiments, and we showed that using the ACO for feature selection improves both accuracy and runtime performance of classification. We also showed that the proposed ACO based algorithm can select better features with respect to the well-known information gain and chi square feature selection methods. PMID:25136678

  3. An ant colony optimization based feature selection for web page classification.

    PubMed

    Saraç, Esra; Özel, Selma Ayşe

    2014-01-01

    The increased popularity of the web has caused the inclusion of huge amount of information to the web, and as a result of this explosive information growth, automated web page classification systems are needed to improve search engines' performance. Web pages have a large number of features such as HTML/XML tags, URLs, hyperlinks, and text contents that should be considered during an automated classification process. The aim of this study is to reduce the number of features to be used to improve runtime and accuracy of the classification of web pages. In this study, we used an ant colony optimization (ACO) algorithm to select the best features, and then we applied the well-known C4.5, naive Bayes, and k nearest neighbor classifiers to assign class labels to web pages. We used the WebKB and Conference datasets in our experiments, and we showed that using the ACO for feature selection improves both accuracy and runtime performance of classification. We also showed that the proposed ACO based algorithm can select better features with respect to the well-known information gain and chi square feature selection methods. PMID:25136678

  4. Comments on Hudesman and Page's reply to Fudin's comments on Hudesman, Page and Rautianen's subliminal psychodynamic activation experiment.

    PubMed

    Fudin, R

    1993-06-01

    Hudesman and Page's contention that Gustafson and Källmén's 1991 results indicate that subsequent subliminal psychodynamic activation experiments do not require the controls suggested by Fudin in 1986 is questioned. The rationale for Fudin's 1993 comment concerning the limited generalizability of Hudesman, et al.'s (1992) results, a comment Hudesman and Page contended is unfounded, is discussed. PMID:8321599

  5. Shakespeare Page to Stage: An Active Approach to "Othello."

    ERIC Educational Resources Information Center

    Thomas, Peter

    1994-01-01

    Presents an account of how one English teacher taught William Shakespeare's "Othello" through dramatics in a challenging way. Considers how teachers of drama might discuss props, stage directions, and the proper handling of Desdemona's handkerchief. Explains how teachers should try to take the plays from "page to stage." (HB)

  6. 75 FR 76080 - Agency Information Collection (VetBiz Vendor Information Pages Verification Program) Activity...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-07

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF VETERANS AFFAIRS Agency Information Collection (VetBiz Vendor Information Pages Verification Program) Activity... . Please refer to ``OMB Control No. 2900- 0675.'' SUPPLEMENTAL INFORMATION: Title: VetBiz...

  7. 75 FR 60169 - Proposed Information Collection (Vetbiz Vendor Information Pages Verification Program) Activity...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-29

    ... AFFAIRS Proposed Information Collection (Vetbiz Vendor Information Pages Verification Program) Activity... opportunity for public comment on the proposed collection of certain information by the agency. Under the... Register concerning each proposed collection of information, including each proposed extension of...

  8. The Green Pages: Environmental Education Activities K-12.

    ERIC Educational Resources Information Center

    Clearing, 1991

    1991-01-01

    Presented are 38 environmental education activities for grades K-12. Topics include seed dispersal, food chains, plant identification, sizes and shapes, trees, common names, air pollution, recycling, temperature, litter, water conservation, photography, insects, urban areas, diversity, natural cycles, rain, erosion, phosphates, human population,…

  9. The Green Pages: Environmental Education Activities K-12.

    ERIC Educational Resources Information Center

    Clearing, 1990

    1990-01-01

    Presented are 37 environmental science activities for students in grades K-12. Topics include water pollution, glaciers, protective coloration, shapes in nature, environmental impacts, recycling, creative writing, litter, shapes found in nature, color, rain cycle, waste management, plastics, energy, pH, landfills, runoff, watersheds,…

  10. The Green Pages: Environmental Education Activities K-12.

    ERIC Educational Resources Information Center

    Clearing, 1990

    1990-01-01

    Presented are 20 science activities for students K-12. Topics include role playing, similarities between urban and forest communities, ecosystems, garbage, recycling, food production, habitats, insects, tidal zone, animals, diversity, interest groups, rivers, spaceship earth, ecological interactions, and the cost of recreation. (KR)

  11. Automated grading of homework assignments and tests in introductory and intermediate statistics courses using active server pages.

    PubMed

    Stockburger, D W

    1999-05-01

    Active server pages permit a software developer to customize the Web experience for users by inserting server-side script and database access into Web pages. This paper describes applications of these techniques and provides a primer on the use of these methods. Applications include a system that generates and grades individualized homework assignments and tests for statistics students. The student accesses the system as a Web page, prints out the assignment, does the assignment, and enters the answers on the Web page. The server, running on NT Server 4.0, grades the assignment, updates the grade book (on a database), and returns the answer key to the student. PMID:10495807

  12. 76 FR 2754 - Agency Information Collection (Pay Now Enter Info Page) Activity Under OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-14

    ... payments through VA's Pay Now Enter Info Page website. Data enter on the Pay Now Enter Info Page is redirected to the Department of Treasury's Pay.gov website allowing claimants to make payments with credit...

  13. ACSM Fit Society Page

    MedlinePlus

    ... Physical Activity Marketplace Health & Physical Activity Reference Database Public Information Newsletters ACSM Blog ACSM Blog Search By ... Activity Marketplace Health & Physical Activity Reference Database Home Public Information Newsletters Fit Society Page ACSM Fit Society ® ...

  14. Coevolution of active vision and feature selection.

    PubMed

    Floreano, Dario; Kato, Toshifumi; Marocco, Davide; Sauser, Eric

    2004-03-01

    We show that complex visual tasks, such as position- and size-invariant shape recognition and navigation in the environment, can be tackled with simple architectures generated by a coevolutionary process of active vision and feature selection. Behavioral machines equipped with primitive vision systems and direct pathways between visual and motor neurons are evolved while they freely interact with their environments. We describe the application of this methodology in three sets of experiments, namely, shape discrimination, car driving, and robot navigation. We show that these systems develop sensitivity to a number of oriented, retinotopic, visual-feature-oriented edges, corners, height, and a behavioral repertoire to locate, bring, and keep these features in sensitive regions of the vision system, resembling strategies observed in simple insects. PMID:15052484

  15. Final comments on Hudesman, Page, and Rautiainen's (1992) subliminal psychodynamic activation experiment.

    PubMed

    Fudin, R

    1993-10-01

    Hudesman, et al.'s (1992) contention that their finding shows that subliminal psychodynamic activation (SPA) improved academic performance is questioned. That experiment lacked controls outlined by Fudin in 1986 which are needed to support the assumption that a positive SPA outcome is effected because the meaning of an entire experimental message is encoded. In 1993 Hudesman and Page argued that Gustafson and Källmén's 1991 results, obtained with such controls, indicated that the controls do not have to be used in subsequent SPA experiments. The 1990 results of Greenberg and of Kothera, Fudin, and Nicastro, however, do not support those of Gustafson and Källmén. From a different perspective, it is argued that good experimental controls are needed in all SPA experiments because they increase internal validity. Given that Hudesman, et al.'s subjects scored in a limited range on the mathematics portion of the 1978 CUNY Skills Assessment Test, the implication that their result can be generalized to all subjects is questioned. PMID:8247655

  16. Desired features of smartphone applications promoting physical activity.

    PubMed

    Rabin, Carolyn; Bock, Beth

    2011-12-01

    Approximately one-third of adults in the United States are physically inactive. This is a significant public health concern as physical activity (PA) can influence the risk of cardiovascular disease, diabetes, and certain forms of cancer. To minimize these health risks, effective PA interventions must be developed and disseminated to the vast number of individuals who remain sedentary. Smartphone technology presents an exciting opportunity for delivering PA interventions remotely. Although a number of PA applications are currently available for smartphones, these "apps" are not based on established theories of health behavior change and most do not include evidence-based features (e.g., reinforcement and goal setting). Our aim was to collect formative data to develop a smartphone PA app that is empirically and theoretically-based and incorporates user preferences. We recruited 15 sedentary adults to test three currently available PA smartphone apps and provide qualitative and quantitative feedback. Findings indicate that users have a number of specific preferences with regard to PA app features, including that apps provide automatic tracking of PA (e.g., steps taken and calories burned), track progress toward PA goals, and integrate a music feature. Participants also preferred that PA apps be flexible enough to be used with several types of PA, and have well-documented features and user-friendly interfaces (e.g., a one-click main page). When queried by the researcher, most participants endorsed including goal-setting and problem-solving features. These findings provide a blue print for developing a smartphone PA app that incorporates evidence-based components and user preferences. PMID:22010977

  17. Land Use and Climate Impacts on Fluvial Systems (LUCIFS): A PAGES - Focus 4 (PHAROS) research activity

    NASA Astrophysics Data System (ADS)

    Dearing, John; Hoffmann, Thomas

    2010-05-01

    LUCIFS is a global research program which is concerned with understanding past interactions between climate, human activity and fluvial systems. Its focus is on evaluating the geomorphic impact of humans on landscapes, with a strong emphasis on geomorphological and sedimentological perspectives on mid- to long-term man-landscape interactions. Of particular relevance are aspects of sediment redistribution systems such as non-linear behaviour, the role of system configuration, scale effects, and emergent properties Over the last decade the LUCIFS program has been investigating both contemporary and long-term river response to global change with the principal aims of i)quantifying land use and climate change impacts of river-borne fluxes of water, sediment, C, N and P; ii) identification of key controls on these fluxes at the catchment scale; and iii) identification of the feedback on both human society and biogeochemical cycles of long-term changes in the fluxes of these materials The major scientific tasks of the LUCIFS-program are: • synthesising results of regional case studies • identify regional gaps and encouraging new case studies • addressing research gaps and formulating new research questions • organising workshops and conferences In this paper we present the LUCIFS program within the new PAGES structure. LUCIFS is located in the Focus 4 (PHAROS) dealing with how a knowledge of human-climate-ecosystem interactions in the past can help inform understanding and management today. In conjunction with the other working groups HITE (Human Impacts on Terrestrial Ecosystems), LIMPACS (Human Impacts on Lake Ecosystems) and IHOPE (Integrated History of People on Earth) PHAROS aims to compare regional-scale reconstructions of environmental and climatic processes using natural archives, documentary and instrumental data, with evidence of past human activity obtained from historical, paleoecological and archaeological records.

  18. Basics. [A Compilation of Learning Activities Pages from Seven Issues of Instructor Magazine, September 1982 through March 1983 and May 1983.

    ERIC Educational Resources Information Center

    Instructor, 1983

    1983-01-01

    This collection of 18 learning activities pages focuses on the subject areas of science, language arts, mathematics, and social studies. The science activities pages concern the study of earthquakes, sound, environmental changes, snails and slugs, and friction. Many of the activities are in the form of experiments for the students to perform.…

  19. Physical activity

    MedlinePlus

    ... this page: //medlineplus.gov/ency/article/001941.htm Physical activity To use the sharing features on this page, please enable JavaScript. Physical activity -- which includes an active lifestyle and routine exercise -- ...

  20. OBSERVED ENVIRONMENTAL FEATURES AND THE PHYSICAL ACTIVITY OF ADOLESCENT MALES

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Background: It has recently been reported that adult physical activity was associated with environmental features. The aim of this study was to determine whether environmental features were associated with physical activity among male adolescents. Methods: Physical activity levels of 210 Boy Scouts ...

  1. The Green Pages Environmental Education Activities K-12: Gardens for Young Growing Lives.

    ERIC Educational Resources Information Center

    Larson, Jan

    1997-01-01

    Describes several gardening activities that can be kept simple or used as a foundation for more in-depth projects. Activities include setting up an indoor garden spot, making compost which helps students understand the terms "decompose" and "compost", watching plants drink in which students measure water movement in plants, making herb gardens,…

  2. Monitoring Activation of the Antiviral Pattern Recognition Receptors RIG-I And PKR By Limited Protease Digestion and Native PAGE

    PubMed Central

    Weber, Michaela; Weber, Friedemann

    2014-01-01

    Host defenses to virus infection are dependent on a rapid detection by pattern recognition receptors (PRRs) of the innate immune system. In the cytoplasm, the PRRs RIG-I and PKR bind to specific viral RNA ligands. This first mediates conformational switching and oligomerization, and then enables activation of an antiviral interferon response. While methods to measure antiviral host gene expression are well established, methods to directly monitor the activation states of RIG-I and PKR are only partially and less well established. Here, we describe two methods to monitor RIG-I and PKR stimulation upon infection with an established interferon inducer, the Rift Valley fever virus mutant clone 13 (Cl 13). Limited trypsin digestion allows to analyze alterations in protease sensitivity, indicating conformational changes of the PRRs. Trypsin digestion of lysates from mock infected cells results in a rapid degradation of RIG-I and PKR, whereas Cl 13 infection leads to the emergence of a protease-resistant RIG-I fragment. Also PKR shows a virus-induced partial resistance to trypsin digestion, which coincides with its hallmark phosphorylation at Thr 446. The formation of RIG-I and PKR oligomers was validated by native polyacrylamide gel electrophoresis (PAGE). Upon infection, there is a strong accumulation of RIG-I and PKR oligomeric complexes, whereas these proteins remained as monomers in mock infected samples. Limited protease digestion and native PAGE, both coupled to western blot analysis, allow a sensitive and direct measurement of two diverse steps of RIG-I and PKR activation. These techniques are relatively easy and quick to perform and do not require expensive equipment. PMID:25146252

  3. Comments on Hudesman, Page, and Rautiainen's (1992) subliminal psychodynamic activation experiment.

    PubMed

    Fudin, R

    1993-02-01

    Hudesman, et al.'s (1992) contention that their finding and those of Ariam (1979), Parker (1982), and Cook (1985) show that subliminal psychodynamic activation (SPA) can improve academic performance is questioned. Results obtained from experiments using methodological innovations (Fudin, 1986) would allow a clearer interpretation of positive SPA outcomes. PMID:8451149

  4. The Foreign Language Feature Film and Language Teaching Activities.

    ERIC Educational Resources Information Center

    Chappell, Martin

    1986-01-01

    Analysis of foreign language films, featuring consideration of film sequence, image and film analysis, and literary adaptation, is an effective teaching activity with foreign language students. An example illustrates film analysis activities in a first-year French class. (CB)

  5. Web Page Design.

    ERIC Educational Resources Information Center

    Lindsay, Lorin

    Designing a web home page involves many decisions that affect how the page will look, the kind of technology required to use the page, the links the page will provide, and kinds of patrons who can use the page. The theme of information literacy needs to be built into every web page; users need to be taught the skills of sorting and applying…

  6. 47 CFR 79.109 - Activating accessibility features.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... ACCESSIBILITY OF VIDEO PROGRAMMING Apparatus § 79.109 Activating accessibility features. (a) Requirements... video programming transmitted in digital format simultaneously with sound, including apparatus designed to receive or display video programming transmitted in digital format using Internet protocol,...

  7. Features for voice activity detection: a comparative analysis

    NASA Astrophysics Data System (ADS)

    Graf, Simon; Herbig, Tobias; Buck, Markus; Schmidt, Gerhard

    2015-12-01

    In many speech signal processing applications, voice activity detection (VAD) plays an essential role for separating an audio stream into time intervals that contain speech activity and time intervals where speech is absent. Many features that reflect the presence of speech were introduced in literature. However, to our knowledge, no extensive comparison has been provided yet. In this article, we therefore present a structured overview of several established VAD features that target at different properties of speech. We categorize the features with respect to properties that are exploited, such as power, harmonicity, or modulation, and evaluate the performance of some dedicated features. The importance of temporal context is discussed in relation to latency restrictions imposed by different applications. Our analyses allow for selecting promising VAD features and finding a reasonable trade-off between performance and complexity.

  8. Bootstrapping structured page segmentation

    NASA Astrophysics Data System (ADS)

    Ma, Huanfeng; Doermann, David S.

    2003-01-01

    In this paper, we present an approach to the bootstrap learning of a page segmentation model. The idea evolves from attempts to segment dictionaries that often have a consistent page structure, and is extended to the segmentation of more general structured documents. In cases of highly regular structure, the layout can be learned from examples of only a few pages. The system is first trained using a small number of samples, and a larger test set is processed based on the training result. After making corrections to a selected subset of the test set, these corrected samples are combined with the original training samples to generate bootstrap samples. The newly created samples are used to retrain the system, refine the learned features and resegment the test samples. This procedure is applied iteratively until the learned parameters are stable. Using this approach, we do not need to initially provide a large set of training samples. We have applied this segmentation to many structured documents such as dictionaries, phone books, spoken language transcripts, and obtained satisfying segmentation performance.

  9. Active transportation safety features around schools in Canada.

    PubMed

    Pinkerton, Bryn; Rosu, Andrei; Janssen, Ian; Pickett, William

    2013-11-01

    The purpose of this study was to describe the presence and quality of active transportation safety features in Canadian school environments that relate to pedestrian and bicycle safety. Variations in these features and associated traffic concerns as perceived by school administrators were examined by geographic status and school type. The study was based on schools that participated in 2009/2010 Health Behaviour in School-aged Children (HBSC) survey. ArcGIS software version 10 and Google Earth were used to assess the presence and quality of ten different active transportation safety features. Findings suggest that there are crosswalks and good sidewalk coverage in the environments surrounding most Canadian schools, but a dearth of bicycle lanes and other traffic calming measures (e.g., speed bumps, traffic chokers). Significant urban/rural inequities exist with a greater prevalence of sidewalk coverage, crosswalks, traffic medians, and speed bumps in urban areas. With the exception of bicycle lanes, the active transportation safety features that were present were generally rated as high quality. Traffic was more of a concern to administrators in urban areas. This study provides novel information about active transportation safety features in Canadian school environments. This information could help guide public health efforts aimed at increasing active transportation levels while simultaneously decreasing active transportation injuries. PMID:24185844

  10. CTAB-PAGE.

    PubMed

    Simpson, Richard J

    2010-04-01

    Although SDS-PAGE is the method of choice for most denaturing gel electrophoresis procedures, the anionic detergent SDS still presents some drawbacks. For example, SDS forms crystals at low temperatures and, in some cases, causes proteins to aggregate or precipitate. In addition, some proteins are not well-resolved in SDS gels or may migrate anomalously. In these situations, the use of a cationic detergent for PAGE offers an alternative approach. The system described in this protocol uses the cationic detergent cetyltrimethyl ammonium bromide (CTAB) and includes a stacking gel based on the zwitterion arginine (used as a stacking agent) and tricine (N-tris[hydroxymethyl]-methylglycine) used as a counterion and buffer. Some proteins separated on the CTAB electrophoresis system retain their native enzymatic activity, provided the samples are prepared without boiling and without the addition of a reducing agent. PMID:20360366

  11. Unconscious Semantic Activation Depends on Feature-Specific Attention Allocation

    ERIC Educational Resources Information Center

    Spruyt, Adriaan; De Houwer, Jan; Everaert, Tom; Hermans, Dirk

    2012-01-01

    We examined whether semantic activation by subliminally presented stimuli is dependent upon the extent to which participants assign attention to specific semantic stimulus features and stimulus dimensions. Participants pronounced visible target words that were preceded by briefly presented, masked prime words. Both affective and non-affective…

  12. Masked Primes Activate Feature Representations in Reading Aloud

    ERIC Educational Resources Information Center

    Mousikou, Petroula; Roon, Kevin D.; Rastle, Kathleen

    2015-01-01

    Theories of reading aloud are silent about the role of subphonemic/subsegmental representations in translating print to sound. However, there is empirical evidence suggesting that feature representations are activated in speech production and visual word recognition. In the present study, we sought to determine whether masked primes activate…

  13. Learning Behavior Characterization with Multi-Feature, Hierarchical Activity Sequences

    ERIC Educational Resources Information Center

    Ye, Cheng; Segedy, James R.; Kinnebrew, John S.; Biswas, Gautam

    2015-01-01

    This paper discusses Multi-Feature Hierarchical Sequential Pattern Mining, MFH-SPAM, a novel algorithm that efficiently extracts patterns from students' learning activity sequences. This algorithm extends an existing sequential pattern mining algorithm by dynamically selecting the level of specificity for hierarchically-defined features…

  14. FDA Kids' Home Page

    MedlinePlus

    ... Stay Healthy! Kids & Teens CVM Kid's Page National Agricultural Library Kids and Teens page - ? - Spotlight Pill Bottle ... For Government For Press Combination Products Advisory Committees Science & Research Regulatory Information Safety Emergency Preparedness International Programs ...

  15. Application of musical timbre discrimination features to active sonar classification

    NASA Astrophysics Data System (ADS)

    Young, Victor W.; Hines, Paul C.; Pecknold, Sean

    2005-04-01

    In musical acoustics significant effort has been devoted to uncovering the physical basis of timbre perception. Most investigations into timbre rely on multidimensional scaling (MDS), in which different musical sounds are arranged as points in multidimensional space. The Euclidean distance between points corresponds to the perceptual distance between sounds and the multidimensional axes are linked to measurable properties of the sounds. MDS has identified numerous temporal and spectral features believed to be important to timbre perception. There is reason to believe that some of these features may have wider application in the disparate field of underwater acoustics, since anecdotal evidence suggests active sonar returns from metallic objects sound different than natural clutter returns when auralized by human operators. This is particularly encouraging since attempts to develop robust automatic classifiers capable of target-clutter discrimination over a wide range of operational conditions have met with limited success. Spectral features relevant to target-clutter discrimination are believed to include click-pitch and envelope irregularity; relevant temporal features are believed to include duration, sub-band attack/decay time, and time separation pitch. Preliminary results from an investigation into the role of these timbre features in target-clutter discrimination will be presented. [Work supported by NSERC and GDC.

  16. Web Page Authoring Tools: Comparison and Trends.

    ERIC Educational Resources Information Center

    Craney, Linda

    Initially available from universities and individual enthusiasts, software tools to author World Wide Web pages are maturing into very feature-rich applications and are now offered by large corporations. These applications are enabling more companies to create and maintain pages themselves on the Web or on corporate Intranets. The market continues…

  17. ON THE 10 mum SILICATE FEATURE IN ACTIVE GALACTIC NUCLEI

    SciTech Connect

    Nikutta, Robert; Elitzur, Moshe; Lacy, Mark E-mail: moshe@pa.uky.ed

    2009-12-20

    The 10 mum silicate feature observed with Spitzer in active galactic nuclei (AGNs) reveals some puzzling behavior. It (1) has been detected in emission in type 2 sources, (2) shows broad, flat-topped emission peaks shifted toward long wavelengths in several type 1 sources, and (3) is not seen in deep absorption in any source observed so far. We solve all three puzzles with our clumpy dust radiative transfer formalism. Addressing (1), we present the spectral energy distribution (SED) of SST1721+6012, the first type 2 quasar observed to show a clear 10 mum silicate feature in emission. Such emission arises in models of the AGN torus easily when its clumpy nature is taken into account. We constructed a large database of clumpy torus models and performed extensive fitting of the observed SED. We find that the cloud radial distribution varies as r {sup -1.5} and the torus contains 2-4 clouds along radial equatorial rays, each with optical depth at visual approx60-80. The source bolometric luminosity is approx3 x 10{sup 12} L{sub sun}. Our modeling suggests that approx<35% of objects with tori sharing these characteristics and geometry would have their central engines obscured. This relatively low obscuration probability can explain the clear appearance of the 10 mum emission feature in SST1721+6012 together with its rarity among other QSO2. Investigating (2), we also fitted the SED of PG1211+143, one of the first type 1 QSOs with a 10 mum silicate feature detected in emission. Together with other similar sources, this QSO appears to display an unusually broadened feature whose peak is shifted toward longer wavelengths. Although this led to suggestions of non-standard dust chemistry in these sources, our analysis fits such SEDs with standard galactic dust; the apparent peak shifts arise from simple radiative transfer effects. Regarding (3), we find additionally that the distribution of silicate feature strengths among clumpy torus models closely resembles the observed

  18. Features of the Active Evening Plasma Sheet from MMS

    NASA Astrophysics Data System (ADS)

    Moore, T. E.; Chandler, M. O.; Avanov, L. A.; Burch, J. L.; Coffey, V. N.; Ergun, R. E.; Fuselier, S. A.; Gershman, D. J.; Giles, B. L.; Lavraud, B.; MacDonald, E.; Mauk, B.; Mukai, T.; Nakamura, R.; Pollock, C. J.; Russell, C. T.; Saito, Y.; Sauvaud, J. A.; Torbert, R. B.; Yokota, S.

    2015-12-01

    The Magnetospheric Multiscale (MMS) mission, consisting of four identical plasmas and fields observatories, was launched into a 12 RE elliptical equatorial orbit in March 2015 and was in the process of being commissioned through August 2015. During commissioning, the orbit apogee rotated from near midnight through the evening toward the dusk sector and occasionally captured new observations of the plasma sheet, its boundary layers, and the magnetospheric tail lobes. On 22-23 June, an especially active plasma sheet was involved in a major geospace storm that developed a ring current with 200 nT DST. We report on the ion kinetic and flow features of this active plasma sheet, comparing them with familiar observations from earlier missions, as an exercise in validating the MMS observations and assessing their capabilities to provide higher time resolution in multi-point views of thin, fast-moving structures. The observed features include but are not limited to cold lobal wind streams in the lobes, tailward flowing auroral beams and conics, hot earthward field-aligned flows and counter-flows, fast cross-field convection of some flows toward the neutral sheet, and the hot isotropic plasma sheet proper. Relationships between these features, the ionosphere, and the reconnecting magnetotail will be explored and discussed, seeking preliminary conclusions.

  19. Chemical and structural features influencing the biological activity of curcumin.

    PubMed

    Priyadarsini, K Indira

    2013-01-01

    Curcumin, a polyphenolic natural product, exhibits therapeutic activity against a number of diseases, attributed mainly to its chemical structure and unique physical, chemical, and biological properties. It is a diferuloyl methane molecule [1,7-bis (4-hydroxy-3- methoxyphenyl)-1,6-heptadiene-3,5-dione)] containing two ferulic acid residues joined by a methylene bridge. It has three important functionalities: an aromatic o-methoxy phenolic group, α, β-unsaturated β-diketo moiety and a seven carbon linker. Extensive research in the last two decades has provided evidence for the role of these different functional groups in its crucial biological activities. A few highlights of chemical structural features associated with the biological activity of curcumin are: The o-methoxyphenol group and methylenic hydrogen are responsible for the antioxidant activity of curcumin, and curcumin donates an electron/ hydrogen atom to reactive oxygen species. Curcumin interacts with a number of biomolecules through non-covalent and covalent binding. The hydrogen bonding and hydrophobicity of curcumin, arising from the aromatic and tautomeric structures along with the flexibility of the linker group are responsible for the non-covalent interactions. The α, β-unsaturated β-diketone moiety covalently interacts with protein thiols, through Michael reaction. The β-diketo group forms chelates with transition metals, there by reducing the metal induced toxicity and some of the metal complexes exhibit improved antioxidant activity as enzyme mimics. New analogues with improved activity are being developed with modifications on specific functional groups of curcumin. The physico-chemical and structural features associated with some of the biological activities of curcumin and important analogues are summarized in this article. PMID:23116315

  20. Active shape models with optimised texture features for radiotherapy

    NASA Astrophysics Data System (ADS)

    Cheng, K.; Montgomery, D.; Yang, F.; McLaren, D. B.; McLaughlin, S.; Nailon, W. H.

    2014-03-01

    There is now considerable interest in radiation oncology on the use of shape models of anatomy to improve target delineation and assess anatomical disparity at time of radiotherapy. In this paper a texture based active shape model (ASM) is presented for automatic delineation of the gross tumor volume (GTV), containing the prostate, on computed tomography (CT) images of prostate cancer patients. The model was trained on two-dimensional (2D) contours identified by a radiation oncologist on sequential CT image slices. A three-dimensional (3D) GTV shape was constructed from these and iteratively aligned using Procrustes analysis. To train the model the shape deformation variance was learnt using the Active Shape Model (ASM) approach. In a novel development to this approach a profile feature was selected from pre-computed texture features by minimizing the Mahalanobis distance to obtain the most distinct feature for each landmark. The interior of the GTV was modelled using quantile histograms to initialize the shape model on new cases. From the archive of 42 cases of contoured CT scans, 32 cases were randomly selected for training the model and 10 cases for evaluating performance. The gold standard was defined by the radiation oncologist. The shape model achieved an overall Dice coefficient of 0.81 for all test cases. Performance was found to increase, mean Dice coefficient of 0.87, when the volume size of the new case was similar to the mean shape of the model. With further work the approach has the potential to be used in real-time delineation of target volumes and improve segmentation accuracy.

  1. Wetlands and Web Pages.

    ERIC Educational Resources Information Center

    Tisone-Bartels, Dede

    1998-01-01

    Argues that the preservation of areas like the Shoreline Park (California) wetlands depends on educating students about the value of natural resources. Describes the creation of a Web page on the wetlands for third-grade students by seventh-grade art and ecology students. Outlines the technical process of developing a Web page. (DSK)

  2. Modeling place field activity with hierarchical slow feature analysis

    PubMed Central

    Schönfeld, Fabian; Wiskott, Laurenz

    2015-01-01

    What are the computational laws of hippocampal activity? In this paper we argue for the slowness principle as a fundamental processing paradigm behind hippocampal place cell firing. We present six different studies from the experimental literature, performed with real-life rats, that we replicated in computer simulations. Each of the chosen studies allows rodents to develop stable place fields and then examines a distinct property of the established spatial encoding: adaptation to cue relocation and removal; directional dependent firing in the linear track and open field; and morphing and scaling the environment itself. Simulations are based on a hierarchical Slow Feature Analysis (SFA) network topped by a principal component analysis (ICA) output layer. The slowness principle is shown to account for the main findings of the presented experimental studies. The SFA network generates its responses using raw visual input only, which adds to its biological plausibility but requires experiments performed in light conditions. Future iterations of the model will thus have to incorporate additional information, such as path integration and grid cell activity, in order to be able to also replicate studies that take place during darkness. PMID:26052279

  3. [Features of active control used in pharmacological studies].

    PubMed

    Nikol'skaia, K A; Kondashevskaia, M V

    2003-09-01

    The effects of 5 injections of salt solution and unfractionary heparin in dose 0.36 microgram/kg (Serva, Germany 10 kDa, activity 180 U/mg) have been studied in Wistar rats. It was found that two injections of salt solution were enough to form a stable defensive state in all rats which was manifested as an expectation of pain in tail-flick testing. The defensive motivation provoked by the injections negatively influenced the learning process as saline-induced rats refused to solve a food-getting task in a problem situation. Explorative and locomotor activities were depressed in these rats and were accompanied by numerous stressful and neurotic-like manifestations. Unlike saline-rats, practically all heparinized-rats instead of 45% of intact rats were able to solve a cognitive task despite the injections. Anxiety was decreased, but sensitivity to different external factors was increased in the heparin-induced rats. Formed habit in these rats was characterized by a high organization and stability. However, the majority heparin effects in tail-flick test were discovered when comparing the heparin-induced rats with intact ones and were not observed in comparison with the saline-rats. It is suggested that the saline-control should be considered as specific control having defensive features which are necessary to take into account in interpretation of effects of other pharmacological preparations. PMID:14758633

  4. Making Pages That Move.

    ERIC Educational Resources Information Center

    Gepner, Ivan

    2001-01-01

    Explains the mechanism of producing dynamic computer pages which is based on three technologies: (1) the document object model; (2) cascading stylesheets; and (3) javascript. Discusses the applications of these techniques in genetics and developmental biology. (YDS)

  5. Practice Audit in Gastroenterology (PAGE) program: A novel approach to continuing professional development

    PubMed Central

    Armstrong, David; Hollingworth, Roger; Gardiner, Tara; Klassen, Michael; Smith, Wendy; Hunt, Richard H; Barkun, Alan; Gould, Michael; Leddin, Desmond

    2006-01-01

    BACKGROUND: Practice audit is an important component of continuing professional development that may more readily be undertaken if it were less complex. This qualitative study assessed the use of personal digital assistants to facilitate data collection and review. METHODS: Personal digital assistants programmed with standard questionnaires related to upper gastrointestinal endoscopies (Practice Audit in Gastroenterology-Endoscopy [‘PAGE-Endo’]) and colonoscopies (PAGE-Colonoscopy [‘PAGE-Colo’]) were provided to Canadian gastroenterologists, surgeons and internists. Over a three-week audit period, participants recorded indications, and the expected (E) and reported (R) findings for each procedure. Thereafter, participants recorded compliance with reporting, the ease of use and value of the PAGE program, and their willingness to perform another audit. RESULTS: Over 15 to 18 months, 173 participants completed PAGE-Endo (6168 procedures) and 111 completed PAGE-Colo (4776 procedures). Most respondents noted that PAGE was easy to use (99%), beneficial (88% to 95%), and that they were willing undertake another audit (92% to 95%). In PAGE-Endo, alarm features were prevalent (55%), but major reported findings were less common than expected: esophagitis (E 29.9%, R 14.8%), esophageal stricture (E 8.3%, R 3.6%), gastric ulcer (E 17.0%, R 4.7%), gastric cancer (E 4.3%, R 1.0%) and duodenal ulcer (E 11.5%, R 5.7%). In PAGE-Colo, more colonoscopies were performed for symptom investigation (55%) than for screening (25%) or surveillance (20%). There were marked interprovincial variations with respect to sedation, biopsies and technical aspects of colonoscopy. CONCLUSION: Secure, real-time data entry with review of aggregate and individual data in the PAGE program provided an acceptable, straightforward methodology for accredited practice audit activities. PAGE has considerable potential for continuing professional development in gastroenterology and other specialties

  6. Page turning system

    NASA Technical Reports Server (NTRS)

    Kerley, James J. (Inventor); Eklund, Wayne D. (Inventor)

    1992-01-01

    A device for holding reading materials for use by readers without arm mobility is presented. The device is adapted to hold the reading materials in position for reading with the pages displayed to enable turning by use of a rubber tipped stick that is held in the mouth and has a pair of rectangular frames. The frames are for holding and positioning the reading materials opened in reading posture with the pages displayed at a substantially unobstructed sighting position for reading. The pair of rectangular frames are connected to one another by a hinge so the angle between the frames may be varied thereby varying the inclination of the reading material. A pair of bent spring mounted wires for holding opposing pages of the reading material open for reading without substantial visual interference of the pages is mounted to the base. The wires are also adjustable to the thickness of the reading material and have a variable friction adjustment. This enables the force of the wires against the pages to be varied and permits the reader to manipulate the pages with the stick.

  7. Structural features of immunologically active polysaccharides from Ganoderma lucidum.

    PubMed

    Bao, Xing-Feng; Wang, Xue-Song; Dong, Qun; Fang, Ji-Nian; Li, Xiao-Yu

    2002-01-01

    Three polysaccharides, two heteroglycans (PL-1 and PL-4) and one glucan (PL-3), were solubilized from the fruit bodies of Ganoderma lucidum and isolated by anion-exchange and gel-filtration chromatography. Their structural features were elucidated by glycosyl residue and glycosyl linkage composition analyses, partial acid hydrolysis, acetolysis, periodate oxidation, 1D and 2D NMR spectroscopy, and ESI-MS experiments. The data obtained indicated that PL-1 had a backbone consisting of 1,4-linked alpha-D-glucopyranosyl residues and 1,6-linked beta-D-galactopyranosyl residues with branches at O-6 of glucose residues and O-2 of galactose residues, composed of terminal glucose, 1,6-linked glucosyl residues and terminal rhamnose. PL-3 was a highly branched glucan composed of 1,3-linked beta-D-glucopyranosyl residues substituted at O-6 with 1,6-linked glucosyl residues. PL-4 was comprised of 1,3-, 1,4-, 1,6-linked beta-D-glucopyranosyl residues and 1,6-linked beta-D-mannopyranosyl residues. These polysaccharides enhanced the proliferation of T- and B-lymphocytes in vitro to varying contents and PL-1 exhibited an immune-stimulating activity in mice. PMID:11809453

  8. Influence of time and length size feature selections for human activity sequences recognition.

    PubMed

    Fang, Hongqing; Chen, Long; Srinivasan, Raghavendiran

    2014-01-01

    In this paper, Viterbi algorithm based on a hidden Markov model is applied to recognize activity sequences from observed sensors events. Alternative features selections of time feature values of sensors events and activity length size feature values are tested, respectively, and then the results of activity sequences recognition performances of Viterbi algorithm are evaluated. The results show that the selection of larger time feature values of sensor events and/or smaller activity length size feature values will generate relatively better results on the activity sequences recognition performances. PMID:24075148

  9. Universal emergence of PageRank

    NASA Astrophysics Data System (ADS)

    Frahm, K. M.; Georgeot, B.; Shepelyansky, D. L.

    2011-11-01

    The PageRank algorithm enables us to rank the nodes of a network through a specific eigenvector of the Google matrix, using a damping parameter α ∈ ]0, 1[. Using extensive numerical simulations of large web networks, with a special accent on British University networks, we determine numerically and analytically the universal features of the PageRank vector at its emergence when α → 1. The whole network can be divided into a core part and a group of invariant subspaces. For α → 1, PageRank converges to a universal power-law distribution on the invariant subspaces whose size distribution also follows a universal power law. The convergence of PageRank at α → 1 is controlled by eigenvalues of the core part of the Google matrix, which are extremely close to unity, leading to large relaxation times as, for example, in spin glasses.

  10. Physical activity advertisements that feature daily well-being improve autonomy and body image in overweight women but not men.

    PubMed

    Segar, Michelle L; Updegraff, John A; Zikmund-Fisher, Brian J; Richardson, Caroline R

    2012-01-01

    The reasons for exercising that are featured in health communications brand exercise and socialize individuals about why they should be physically active. Discovering which reasons for exercising are associated with high-quality motivation and behavioral regulation is essential to promoting physical activity and weight control that can be sustained over time. This study investigates whether framing physical activity in advertisements featuring distinct types of goals differentially influences body image and behavioral regulations based on self-determination theory among overweight and obese individuals. Using a three-arm randomized trial, overweight and obese women and men (aged 40-60 yr, n = 1690) read one of three ads framing physical activity as a way to achieve (1) better health, (2) weight loss, or (3) daily well-being. Framing effects were estimated in an ANOVA model with pairwise comparisons using the Bonferroni correction. This study showed that there are immediate framing effects on physical activity behavioral regulations and body image from reading a one-page advertisement about physical activity and that gender and BMI moderate these effects. Framing physical activity as a way to enhance daily well-being positively influenced participants' perceptions about the experience of being physically active and enhanced body image among overweight women, but not men. The experiment had less impact among the obese study participants compared to those who were overweight. These findings support a growing body of research suggesting that, compared to weight loss, framing physical activity for daily well-being is a better gain-frame message for overweight women in midlife. PMID:22701782

  11. Handley Page metal construction

    NASA Technical Reports Server (NTRS)

    1929-01-01

    In this report Handley Page construction techniques are shown such as: solid-drawn tubular duralumin spars are used in the stabilizer; plain channel sections are used extensively for minor components; and the manner of assembling them into a stabilizer compression strut is shown.

  12. Some features of active regions and bursts in millimetric range.

    NASA Astrophysics Data System (ADS)

    Yu, Xingfeng; Yao, Jinxing

    1995-09-01

    The characteristics of active regions and bursts at mm wavelengths, observed with the 13.7 m radio telescope at Quinghai from Nov 16 to Dec 1, 1993, are analyzed. It appears that the active region collapsed and vanished while there occurred a coronal loop with two polarities. GRE bursts at mm wavelength may be interpreted by thermal gyro-resonance radiation and are part of the chromospheric eruption. There is no indication of FFS in 10 ms recordings.

  13. Feature Selection in Classification of Eye Movements Using Electrooculography for Activity Recognition

    PubMed Central

    Mala, S.; Latha, K.

    2014-01-01

    Activity recognition is needed in different requisition, for example, reconnaissance system, patient monitoring, and human-computer interfaces. Feature selection plays an important role in activity recognition, data mining, and machine learning. In selecting subset of features, an efficient evolutionary algorithm Differential Evolution (DE), a very efficient optimizer, is used for finding informative features from eye movements using electrooculography (EOG). Many researchers use EOG signals in human-computer interactions with various computational intelligence methods to analyze eye movements. The proposed system involves analysis of EOG signals using clearness based features, minimum redundancy maximum relevance features, and Differential Evolution based features. This work concentrates more on the feature selection algorithm based on DE in order to improve the classification for faultless activity recognition. PMID:25574185

  14. Multiplex PageRank.

    PubMed

    Halu, Arda; Mondragón, Raúl J; Panzarasa, Pietro; Bianconi, Ginestra

    2013-01-01

    Many complex systems can be described as multiplex networks in which the same nodes can interact with one another in different layers, thus forming a set of interacting and co-evolving networks. Examples of such multiplex systems are social networks where people are involved in different types of relationships and interact through various forms of communication media. The ranking of nodes in multiplex networks is one of the most pressing and challenging tasks that research on complex networks is currently facing. When pairs of nodes can be connected through multiple links and in multiple layers, the ranking of nodes should necessarily reflect the importance of nodes in one layer as well as their importance in other interdependent layers. In this paper, we draw on the idea of biased random walks to define the Multiplex PageRank centrality measure in which the effects of the interplay between networks on the centrality of nodes are directly taken into account. In particular, depending on the intensity of the interaction between layers, we define the Additive, Multiplicative, Combined, and Neutral versions of Multiplex PageRank, and show how each version reflects the extent to which the importance of a node in one layer affects the importance the node can gain in another layer. We discuss these measures and apply them to an online multiplex social network. Findings indicate that taking the multiplex nature of the network into account helps uncover the emergence of rankings of nodes that differ from the rankings obtained from one single layer. Results provide support in favor of the salience of multiplex centrality measures, like Multiplex PageRank, for assessing the prominence of nodes embedded in multiple interacting networks, and for shedding a new light on structural properties that would otherwise remain undetected if each of the interacting networks were analyzed in isolation. PMID:24205186

  15. Tectonic activity and structural features of active intracontinental normal faults in the Weihe Graben, central China

    NASA Astrophysics Data System (ADS)

    Rao, Gang; Lin, Aiming; Yan, Bing; Jia, Dong; Wu, Xiaojun

    2014-12-01

    This study examines the tectonic activity and structural features of active normal faults in the Weihe Graben, central China. The Weihe Graben is an area with a high level of historic seismicity, and it is one of the intracontinental systems that developed since Tertiary in the extensional environment around the Ordos Block. Analysis of high-resolution remote-sensing imagery data, field observations, and radiocarbon dating results reveal the following: i) active normal faults are mainly developed within a zone < 500 m wide along the southern border of the eastern part of the Weihe Graben; ii) the active faults that have been identified are characterized by stepwise fault scarps dipping into the graben at angles of 40°-71°; iii) there are numerous discontinuous individual fault traces, ranging in length from a few tens of meters to 450 m (generally < 200 m); iv) fault zone structures, topographic features, and fault striations on the main fault planes indicate almost pure normal-slip; and v) late Pleistocene-Holocene terrace risers, loess, and alluvial deposits have been vertically offset by up to ~ 80 m, with a non-uniform dip-slip rate (throw-rates) ranging from ~ 2.1 to 5.7 mm/yr, mostly 2-3 mm/yr. Our results reveal that active normal faults have been developing in the Weihe Graben under an ongoing extensional environment, probably associated with the pre-existing graben and spreading of the continental crust, and this is in contrast with the Ordos Block and neighboring orogenic regions. These results provide new insights into the nature of extensional tectonic deformation in intracontinental graben systems.

  16. An Analysis of Academic Library Web Pages for Faculty

    ERIC Educational Resources Information Center

    Gardner, Susan J.; Juricek, John Eric; Xu, F. Grace

    2008-01-01

    Web sites are increasingly used by academic libraries to promote key services and collections to teaching faculty. This study analyzes the content, location, language, and technological features of fifty-four academic library Web pages designed especially for faculty to expose patterns in the development of these pages.

  17. Project EAGLE (Early Academic Gifted Learning Experience): A Program for Gifted and Talented Students (Grades K-3)--Kindergarten Activity Booklets: Xanthus; Zhack; and Activity Pages H-Z.

    ERIC Educational Resources Information Center

    Merkoski, Kay

    Three activity booklets are presented for implementing Project EAGLE, an enrichment program for gifted and talented kindergarten children. The first activity booklet contains a poem by J. D. Evans titled "In Search of the Xanthus," which describes the search for an imaginary beast that leaves an "X" on the spot where it used to be. The second…

  18. Guaiane sesquiterpenes from Biscogniauxia nummularia featuring potent antigerminative activity.

    PubMed

    Amand, Séverine; Langenfeld, Aude; Blond, Alain; Dupont, Joëlle; Nay, Bastien; Prado, Soizic

    2012-04-27

    Xylaranone, a previously unreported guaiane sesquiterpene along with the known terpenoid xylaranol B and the two mellein derivatives 3,5-dimethyl-8-methoxy-3,4-dihydroisocoumarin and 3,5-dimethyl-8-hydroxy-3,4-dihydroisocoumarin were isolated from Biscogniauxia nummularia. Pogostol was also isolated from this fungus, and in light of our spectroscopic data, its structure was revised and corrected. This fungus, which was isolated as an endophyte from the plum yew Cephalotaxus harringtonia, is also suspected of being a pathogen. Interestingly, we report here the potent antigerminative activity of xylaranone and xylaranol B against seeds of Raphanus sativus at concentrations comparable to glyphosate, a commonly used herbicide. This effect suggests a role for these metabolites in the latent fungal pathogenesis of B. nummularia. PMID:22486738

  19. MedlinePlus FAQ: What's New on Medline Plus Page and Email Updates

    MedlinePlus

    ... the What's New on MedlinePlus page and RSS feed different from the email updates? To use the ... The What's New on MedlinePlus page and RSS feed include alerts about new MedlinePlus features, useful resources, ...

  20. Activity of quinolones against gram-positive cocci: clinical features.

    PubMed

    Giamarellou, H

    1995-01-01

    The potential role of the commercially available fluoroquinolones in the treatment of Gram-positive infections is discussed on the basis of data obtained from animal experiments and clinical trials. In respiratory tract infections, and particularly in community-acquired pneumonia, it is evident that the presently available quinolones cannot be prescribed empirically as first-line therapy because of their borderline activity against Streptococcus pneumoniae and anaerobes. Reports of pneumococcal seeding in other tissues during quinolone therapy render their administration a debatable issue. Experience in endocarditis is limited to the use of ciprofloxacin plus rifampicin in intravenous drug users with right-sided Staphylococcus aureus endocarditis. Patients with staphylococcal osteomyelitis are included among cases of other bone infections. In noncontrolled studies ciprofloxacin, ofloxacin and pefloxacin attained a staphylococcal eradication rate ranging from 70 to 100%, while the addition of rifampicin has been proven to reduce the emergence of resistant mutants during therapy. In soft tissue and skin structure infections that also involve Gram-negative bacteria, ciprofloxacin and ofloxacin eradicated 72.6 and 89% of staphylococci, respectively; however, the presence of diabetes or vascular disease compromised the success of treatment. In staphylococcal peritonitis complicating continuous ambulatory peritoneal dialysis, results with ciprofloxacin given intravenously or intraperitoneally were promising. In infections in neutropenic hosts, success of prophylaxis or therapy is still not clear, since colonisation and breakthrough bacteraemias with viridans streptococci and staphylococci have been reported. Furthermore, therapeutic results are compromised by the low response rate in Gram-positive infections. Despite the reported clinical efficacy of the newer fluoroquinolones, physicians should be alerted to the emergence of staphylococci resistant to fluoroquinolones

  1. 8. Photocopy of printed page (original Page 30 of the ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Photocopy of printed page (original Page 30 of the Souvenir Program 1867-1967 Ridgely Centennial) Photographer unknown. Circa 1967. VIEW NORTHEAST, SOUTHWEST FRONT Ridgely's centennial was celebrated in 1967 and included in the souvenir brochure was page 30. This view shows the subject building with the 1950 modifications to provide for automotive traffic. It was a print of a current photograph. - 510 Central Avenue (Commercial Building), Ridgely, Caroline County, MD

  2. Function Follows Form: Activation of Shape and Function Features during Object Identification

    ERIC Educational Resources Information Center

    Yee, Eiling; Huffstetler, Stacy; Thompson-Schill, Sharon L.

    2011-01-01

    Most theories of semantic memory characterize knowledge of a given object as comprising a set of semantic features. But how does conceptual activation of these features proceed during object identification? We present the results of a pair of experiments that demonstrate that object recognition is a dynamically unfolding process in which function…

  3. Feature diagnosticity and task context shape activity in human scene-selective cortex.

    PubMed

    Lowe, Matthew X; Gallivan, Jason P; Ferber, Susanne; Cant, Jonathan S

    2016-01-15

    Scenes are constructed from multiple visual features, yet previous research investigating scene processing has often focused on the contributions of single features in isolation. In the real world, features rarely exist independently of one another and likely converge to inform scene identity in unique ways. Here, we utilize fMRI and pattern classification techniques to examine the interactions between task context (i.e., attend to diagnostic global scene features; texture or layout) and high-level scene attributes (content and spatial boundary) to test the novel hypothesis that scene-selective cortex represents multiple visual features, the importance of which varies according to their diagnostic relevance across scene categories and task demands. Our results show for the first time that scene representations are driven by interactions between multiple visual features and high-level scene attributes. Specifically, univariate analysis of scene-selective cortex revealed that task context and feature diagnosticity shape activity differentially across scene categories. Examination using multivariate decoding methods revealed results consistent with univariate findings, but also evidence for an interaction between high-level scene attributes and diagnostic visual features within scene categories. Critically, these findings suggest visual feature representations are not distributed uniformly across scene categories but are shaped by task context and feature diagnosticity. Thus, we propose that scene-selective cortex constructs a flexible representation of the environment by integrating multiple diagnostically relevant visual features, the nature of which varies according to the particular scene being perceived and the goals of the observer. PMID:26541082

  4. Identifying Key Features of Effective Active Learning: The Effects of Writing and Peer Discussion

    ERIC Educational Resources Information Center

    Linton, Debra L.; Pangle, Wiline M.; Wyatt, Kevin H.; Powell, Karli N.; Sherwood, Rachel E.

    2014-01-01

    We investigated some of the key features of effective active learning by comparing the outcomes of three different methods of implementing active-learning exercises in a majors introductory biology course. Students completed activities in one of three treatments: discussion, writing, and discussion + writing. Treatments were rotated weekly between…

  5. OBSERVED, GIS, AND SELF-REPORTED ENVIRONMENTAL FEATURES AND ADOLESCENT PHYSICAL ACTIVITY

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Purpose: Examine associations among observed, self-reported, and Geographical Information Systems (GIS) environmental features and physical activity among adolescent males. Design: Cross-sectional study. Setting: Boy Scout troops and neighborhoods in Houston, Texas. Subjects: Two hundred and ten ...

  6. Perceptual metrics and visualization tools for evaluation of page uniformity

    NASA Astrophysics Data System (ADS)

    Nguyen, Minh Q.; Jessome, Renee; Astling, Steve; Maggard, Eric; Nelson, Terry; Shaw, Mark; Allebach, Jan P.

    2014-01-01

    Uniformity is one of the issues of most critical concern for laser electrophotographic (EP) printers. Typically, full coverage constant-tint test pages are printed to assess uniformity. Exemplary nonuniformity defects include mottle, grain, pinholes, and "finger prints". It is a real challenge to make an overall Print Quality (PQ) assessment due to the large coverage of a letter-size, constant-tint printed test page and the variety of possible nonuniformity defects. In this paper, we propose a novel method that uses a block-based technique to analyze the page both visually and metrically. We use a grid of 150 pixels × 150 pixels ( ¼ inch × ¼ inch at 600-dpi resolution) square blocks throughout the scanned page. For each block, we examine two aspects: behavior of its pixels within the block (metrics of graininess) and behavior of the blocks within the printed page (metrics of nonuniformity). Both ΔE (CIE 1976) and the L* lightness channel are employed. For an input scanned page, we create eight visual outputs, each displaying a different aspect of nonuniformity. To apply machine learning, we train scanned pages of different 100% solid colors separately with the support vector machine (SVM) algorithm. We use two metrics as features for the SVM: average dispersion of page lightness and standard deviation in dispersion of page lightness. Our results show that we can predict, with 83% to 90% accuracy, the assignment by a print quality expert of one of two grades of uniformity in the print.

  7. Human activity recognition based on feature selection in smart home using back-propagation algorithm.

    PubMed

    Fang, Hongqing; He, Lei; Si, Hao; Liu, Peng; Xie, Xiaolei

    2014-09-01

    In this paper, Back-propagation(BP) algorithm has been used to train the feed forward neural network for human activity recognition in smart home environments, and inter-class distance method for feature selection of observed motion sensor events is discussed and tested. And then, the human activity recognition performances of neural network using BP algorithm have been evaluated and compared with other probabilistic algorithms: Naïve Bayes(NB) classifier and Hidden Markov Model(HMM). The results show that different feature datasets yield different activity recognition accuracy. The selection of unsuitable feature datasets increases the computational complexity and degrades the activity recognition accuracy. Furthermore, neural network using BP algorithm has relatively better human activity recognition performances than NB classifier and HMM. PMID:25016308

  8. Transform-invariant feature based functional MR image registration and neural activity modelling.

    PubMed

    Gong, Jiaqi; Hao, Qi; Hu, Fei

    2013-01-01

    In this paper, a set of non-rigid image registration and neural activity modelling methods using functional MR Images (fMRI) are proposed based on transform-invariant feature representations. Our work made two contributions. First, we propose to use a transform-invariant feature to improve image registration performance of Iterative Closest Point (ICP) based methods. The proposed feature utilises Gaussian Mixture Models (GMM) to describe the local topological structure of fMRI data. Second, we propose to use a 3-dimensional Scale-Invariant Feature Transform (SIFT) based descriptor to represent neural activities related to drinking behaviour. As a result, neural activities patterns of different subjects drinking water or intaking glucose can be recognised, with strong robustness against various artefacts. PMID:23900434

  9. Writing a Library Home Page.

    ERIC Educational Resources Information Center

    Matsco, Sandra; Campbell, Sharon

    1996-01-01

    Describes how Rochester Hills Public Library (Michigan) planned and implemented their award-winning World Wide Web home page. They evaluated other library sites, clarified goals and audience, used a shared network for communication, and organized the page based on library and community information and Internet resources. Also, provides guidelines…

  10. ACSM Fit Society Page

    MedlinePlus

    ... Exercise Current Sports Medicine Reports Exercise and Sport Sciences Reviews ACSM's Health & Fitness Journal Guidelines Books & Multimedia Sports Medicine Basics Fact Sheets Sports Medicine & Physical Activity Marketplace Health & Physical Activity Reference Database Fit ...

  11. Reese Sorenson's Individual Professional Page

    NASA Technical Reports Server (NTRS)

    Sorenson, Reese; Nixon, David (Technical Monitor)

    1998-01-01

    The subject document is a World Wide Web (WWW) page entitled, "Reese Sorenson's Individual Professional Page." Its can be accessed at "http://george.arc.nasa.gov/sorenson/personal/index.html". The purpose of this page is to make the reader aware of me, who I am, and what I do. It lists my work assignments, my computer experience, my place in the NASA hierarchy, publications by me, awards received by me, my education, and how to contact me. Writing this page was a learning experience, pursuant to an element in my Job Description which calls for me to be able to use the latest computers. This web page contains very little technical information, none of which is classified or sensitive.

  12. RELATIONSHIPS BETWEEN GIS ENVIRONMENTAL FEATURES AND ADOLESCENT MALE PHYSICAL ACTIVITY: GIS CODING DIFFERENCES

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Background: It is not clear if relationships between GIS obtained environmental features and physical activity differ according to the method used to code GIS data. Methods: Physical activity levels of 210 Boy Scouts were measured by accelerometer. Numbers of parks, trails, gymnasia, bus stops, groc...

  13. Wanted: Active Role Models for Today's Kids

    MedlinePlus

    ... this page please turn Javascript on. Feature: Reducing Childhood Obesity Wanted: Active Role Models for Today's Kids Past ... the active role models they can get. "With childhood obesity at an all-time high, we need to ...

  14. Feature activation during word recognition: action, visual, and associative-semantic priming effects

    PubMed Central

    Lam, Kevin J. Y.; Dijkstra, Ton; Rueschemeyer, Shirley-Ann

    2015-01-01

    Embodied theories of language postulate that language meaning is stored in modality-specific brain areas generally involved in perception and action in the real world. However, the temporal dynamics of the interaction between modality-specific information and lexical-semantic processing remain unclear. We investigated the relative timing at which two types of modality-specific information (action-based and visual-form information) contribute to lexical-semantic comprehension. To this end, we applied a behavioral priming paradigm in which prime and target words were related with respect to (1) action features, (2) visual features, or (3) semantically associative information. Using a Go/No-Go lexical decision task, priming effects were measured across four different inter-stimulus intervals (ISI = 100, 250, 400, and 1000 ms) to determine the relative time course of the different features. Notably, action priming effects were found in ISIs of 100, 250, and 1000 ms whereas a visual priming effect was seen only in the ISI of 1000 ms. Importantly, our data suggest that features follow different time courses of activation during word recognition. In this regard, feature activation is dynamic, measurable in specific time windows but not in others. Thus the current study (1) demonstrates how multiple ISIs can be used within an experiment to help chart the time course of feature activation and (2) provides new evidence for embodied theories of language. PMID:26074836

  15. Code AI Personal Web Pages

    NASA Technical Reports Server (NTRS)

    Garcia, Joseph A.; Smith, Charles A. (Technical Monitor)

    1998-01-01

    The document consists of a publicly available web site (george.arc.nasa.gov) for Joseph A. Garcia's personal web pages in the AI division. Only general information will be posted and no technical material. All the information is unclassified.

  16. Using Feature Films To Promote Active Learning in the College Classroom.

    ERIC Educational Resources Information Center

    Gregg, Virginia R.; And Others

    Using feature films to teach undergraduate psychology courses can promote active learning for several reasons. Films can reach students with a variety of learning styles, including those with a visual approach to learning. Also, students seem to enjoy commercial films and their use can help decrease levels of monotony from daily lectures. Feature…

  17. From Monty Python to Total Recall: A Feature Film Activity for the Cognitive Psychology Course.

    ERIC Educational Resources Information Center

    Conner, David B.

    1996-01-01

    Describes a college psychology course activity designed to help students define the parameters of cognitive psychology. Students selected a feature film and a journal article that represented some aspect of cognitive psychology. They then wrote a paper discussing the theoretical and empirical connections between the sources and the topic. (MJP)

  18. The Faculty Web Page: Contrivance or Continuation?

    ERIC Educational Resources Information Center

    Lennex, Lesia

    2007-01-01

    In an age of Internet education, what does it mean for a tenure/tenure-track faculty to have a web page? How many professors have web pages? If they have a page, what does it look like? Do they really need a web page at all? Many universities have faculty web pages. What do those collective pages look like? In what way do they represent the…

  19. Feature Statistics Modulate the Activation of Meaning During Spoken Word Processing.

    PubMed

    Devereux, Barry J; Taylor, Kirsten I; Randall, Billi; Geertzen, Jeroen; Tyler, Lorraine K

    2016-03-01

    Understanding spoken words involves a rapid mapping from speech to conceptual representations. One distributed feature-based conceptual account assumes that the statistical characteristics of concepts' features--the number of concepts they occur in (distinctiveness/sharedness) and likelihood of co-occurrence (correlational strength)--determine conceptual activation. To test these claims, we investigated the role of distinctiveness/sharedness and correlational strength in speech-to-meaning mapping, using a lexical decision task and computational simulations. Responses were faster for concepts with higher sharedness, suggesting that shared features are facilitatory in tasks like lexical decision that require access to them. Correlational strength facilitated responses for slower participants, suggesting a time-sensitive co-occurrence-driven settling mechanism. The computational simulation showed similar effects, with early effects of shared features and later effects of correlational strength. These results support a general-to-specific account of conceptual processing, whereby early activation of shared features is followed by the gradual emergence of a specific target representation. PMID:26043761

  20. Using Activity-Related Behavioural Features towards More Effective Automatic Stress Detection

    PubMed Central

    Giakoumis, Dimitris; Drosou, Anastasios; Cipresso, Pietro; Tzovaras, Dimitrios; Hassapis, George; Gaggioli, Andrea; Riva, Giuseppe

    2012-01-01

    This paper introduces activity-related behavioural features that can be automatically extracted from a computer system, with the aim to increase the effectiveness of automatic stress detection. The proposed features are based on processing of appropriate video and accelerometer recordings taken from the monitored subjects. For the purposes of the present study, an experiment was conducted that utilized a stress-induction protocol based on the stroop colour word test. Video, accelerometer and biosignal (Electrocardiogram and Galvanic Skin Response) recordings were collected from nineteen participants. Then, an explorative study was conducted by following a methodology mainly based on spatiotemporal descriptors (Motion History Images) that are extracted from video sequences. A large set of activity-related behavioural features, potentially useful for automatic stress detection, were proposed and examined. Experimental evaluation showed that several of these behavioural features significantly correlate to self-reported stress. Moreover, it was found that the use of the proposed features can significantly enhance the performance of typical automatic stress detection systems, commonly based on biosignal processing. PMID:23028461

  1. FUNCTION FOLLOWS FORM: ACTIVATION OF SHAPE & FUNCTION FEATURES DURING OBJECT IDENTIFICATION

    PubMed Central

    Yee, Eiling; Huffstetler, Stacy; Thompson-Schill, Sharon L.

    2011-01-01

    Most theories of semantic memory characterize knowledge of a given object as comprising a set of semantic features. But how does conceptual activation of these features proceed during object identification? We present the results of a pair of experiments that demonstrate that object recognition is a dynamically unfolding process in which function follows form. We used eye movements to explore whether activating one object’s concept leads to the activation of others that share perceptual (shape) or abstract (function) features. Participants viewed four-picture displays and clicked on the picture corresponding to a heard word. In critical trials, the conceptual representation of one of the objects in the display was similar in shape or function (i.e., its purpose) to the heard word. Importantly, this similarity was not apparent in the visual depictions (e.g., for the target “frisbee,” the shape-related object was a triangular slice of pizza – a shape that a frisbee cannot take); preferential fixations on the related object were therefore attributable to overlap of the conceptual representations on the relevant features. We observed relatedness effects for both shape and function, but shape effects occurred earlier than function effects. We discuss the implications of these findings for current accounts of the representation of semantic memory. PMID:21417543

  2. Multifractal features of magnetospheric dynamics and their dependence on solar activity

    NASA Astrophysics Data System (ADS)

    Gopinath, Sumesh

    2016-09-01

    In the present study, novel wavelet leaders (WL) based multifractal analysis has been used to get a better knowledge of the self-organization phenomena inherent in complex magnetospheric dynamics during disturbance and quiescent periods, focusing mainly on the intermittent features of auroral electrojet (AE) index. The results derived from the analysis certainly exhibit the phase transition property of magnetosphere system with respect to variabilities in the driving conditions. By using the novel WL method, solar activity dependence/independence of intermittency of magnetospheric proxies such as AE, SYM-H and Dst indices have been compared. The results indicate that the multifractality of AE index does not follow the solar activity cycle while intermittent features of SYM-H and Dst indices show high degree of solar activity dependence. This shows that along with the external solar wind perturbations, certain complex phenomena of internal origin also significantly modulate the dynamics of geomagnetic fluctuations in the auroral region.

  3. North-south asymmetry of different solar activity features during solar cycle 23

    NASA Astrophysics Data System (ADS)

    Bankoti, Neeraj Singh; Joshi, Navin Chandra; Pande, Seema; Pande, Bimal; Pandey, Kavita

    2010-08-01

    A study on north-south (N-S) asymmetry of different solar activity features (DSAF) such as solar proton events, solar active prominences [total, low (⩽40°) and high (⩾50°) latitudes], H α flare indices, soft X-ray flares, monthly mean sunspot areas and monthly mean sunspot numbers carried out from May 1996 to October 2008. Study shows a southern dominance of DSAF during this period. During the rising phase of the cycle 23 the number of DSAF approximately equals on both, the northern and the southern hemispheres. But these activities tend to shift from northern to southern hemisphere during the period 1998-1999. The statistical significance of the asymmetry time series using a χ2-test of goodness of fit indicates that in most of the cases the asymmetry is highly significant, meaning thereby that the asymmetry is a real feature in the N-S distribution of DSAF.

  4. Optimal feature point selection and automatic initialization in active shape model search.

    PubMed

    Lekadir, Karim; Yang, Guang-Zhong

    2008-01-01

    This paper presents a novel approach for robust and fully automatic segmentation with active shape model search. The proposed method incorporates global geometric constraints during feature point search by using interlandmark conditional probabilities. The A* graph search algorithm is adapted to identify in the image the optimal set of valid feature points. The technique is extended to enable reliable and fast automatic initialization of the ASM search. Validation with 2-D and 3-D MR segmentation of the left ventricular epicardial border demonstrates significant improvement in robustness and overall accuracy, while eliminating the need for manual initialization. PMID:18979776

  5. Research on identification of active volcano features based on Landsat TM/ETM+ imagery

    NASA Astrophysics Data System (ADS)

    Kong, Xiangsheng; Qian, Yonggang

    2009-10-01

    Volcanic activity can present unpredictable disasters to city populations living within regions and for people traveling in plane that intersect with ash-laden eruption clouds. Methods of monitoring volcanic activity include searching for variations in the thermal anomaly, clouds resource and subsidence deformation from active volcano. Over any active volcanoes, low spatial resolution satellite image are used to identify changes in eruptive activity, but are of insufficient spatial resolution to map active volcanic features. The Landsat data can be used to identify the thermal characteristics of a series of lava flows at Fuego volcano and Pacaya volcano, Guatemala. We use Landsat TM/ETM+ 7, 5, 4 (displayed in red, green, and blue, respectively) false-color composite of the research region, acquired on 18 December 1989 and 23 January 2000 to indicate the volcano image features which appear halo structure with blue red and yellow. The interpretation flag is obvious which indicate the difference temperature of volcano crater. Spatially varying haze emitted by volcano activity is identified and removed based on Improved Haze Optimized Transform (HOT) which is a robust haze assessing method. With improved spatial resolution in the thermal IR, we are able to map the bifurcation and braiding of underground lava tubes. With higher spatial resolution panchromatic data, we are able to map lava flow fields, trace very high temperature lava channels, and identify an accurate feature associated with a collapsed crater floor. At both Fuego and Pacaya, we are able to use the thermal data to estimate temperature. We can monitor the dynamic change of the two volcanoes using two difference date Landsat data.

  6. Feature integration in visual working memory: parietal gamma activity is related to cognitive coordination.

    PubMed

    Morgan, Helen M; Muthukumaraswamy, Suresh D; Hibbs, Carina S; Shapiro, Kimron L; Bracewell, R Martyn; Singh, Krish D; Linden, David E J

    2011-12-01

    The mechanism by which distinct subprocesses in the brain are coordinated is a central conundrum of systems neuroscience. The parietal lobe is thought to play a key role in visual feature integration, and oscillatory activity in the gamma frequency range has been associated with perception of coherent objects and other tasks requiring neural coordination. Here, we examined the neural correlates of integrating mental representations in working memory and hypothesized that parietal gamma activity would be related to the success of cognitive coordination. Working memory is a classic example of a cognitive operation that requires the coordinated processing of different types of information and the contribution of multiple cognitive domains. Using magnetoencephalography (MEG), we report parietal activity in the high gamma (80-100 Hz) range during manipulation of visual and spatial information (colors and angles) in working memory. This parietal gamma activity was significantly higher during manipulation of visual-spatial conjunctions compared with single features. Furthermore, gamma activity correlated with successful performance during the conjunction task but not during the component tasks. Cortical gamma activity in parietal cortex may therefore play a role in cognitive coordination. PMID:21940605

  7. Perception of race-related features modulates neural activity associated with action observation and imitation.

    PubMed

    Earls, Holly A; Englander, Zoë A; Morris, James P

    2013-05-29

    The present study examines whether race-specific features affect biological motion perception. Activation of the neural action observation and imitation network was measured using functional MRI. During scanning, individuals were asked to imitate and observe basic hand movements of own-race and other-race actors. Results indicate that three key areas often associated with action observation and imitation, the inferior parietal lobule, superior parietal lobule, and superior temporal sulcus, were more active when participants imitated and observed hand movements of own-race relative to other-race actors. These findings indicate that several regions associated with the neural imitation/observation network are sensitive to race-related features. PMID:23571693

  8. Learning through Web Page Design.

    ERIC Educational Resources Information Center

    Peel, Deborah

    2001-01-01

    Describes and evaluates the use of Web page design in an undergraduate course in the United Kingdom on town planning. Highlights include incorporating information and communication technologies into higher education; and a theoretical framework for the use of educational technology. (LRW)

  9. Design of Educational Web Pages

    ERIC Educational Resources Information Center

    Galan, Jose Gomez; Blanco, Soledad Mateos

    2004-01-01

    The methodological characteristics of teaching in primary and secondary education make it necessary to revise the pedagogical and instructive lines with which to introduce the new Information and Communication Technologies into the school context. The construction of Web pages that can be used to improve student learning is, therefore, fundamental…

  10. Optimization studies on the features of an activated charcoal-supported urease system.

    PubMed

    Kibarer, G D; Akovali, G

    1996-08-01

    The adsorption of urease onto a well-defined solid support, petroleum-based activated charcoal, has been achieved to provide the enzymatic hydrolysis of urea. In order to produce a biocompatible surface, the enzyme support system has been coated with hexamethyldisiloxane through plasma polymerization. The quality of the resulting coat was tested by electronic spectroscopy for chemical analysis and scanning electron microscopy techniques. Studies on the adsorption of urease, and activity and stability of the enzyme on the support have been in the direction to optimize the features of the charcoal-supported urease and improve its availability for further use in clinical applications. PMID:8853117

  11. RNA-Seq of Bacillus licheniformis: active regulatory RNA features expressed within a productive fermentation

    PubMed Central

    2013-01-01

    Background The production of enzymes by an industrial strain requires a complex adaption of the bacterial metabolism to the conditions within the fermenter. Regulatory events within the process result in a dynamic change of the transcriptional activity of the genome. This complex network of genes is orchestrated by proteins as well as regulatory RNA elements. Here we present an RNA-Seq based study considering selected phases of an industry-oriented fermentation of Bacillus licheniformis. Results A detailed analysis of 20 strand-specific RNA-Seq datasets revealed a multitude of transcriptionally active genomic regions. 3314 RNA features encoded by such active loci have been identified and sorted into ten functional classes. The identified sequences include the expected RNA features like housekeeping sRNAs, metabolic riboswitches and RNA switches well known from studies on Bacillus subtilis as well as a multitude of completely new candidates for regulatory RNAs. An unexpectedly high number of 855 RNA features are encoded antisense to annotated protein and RNA genes, in addition to 461 independently transcribed small RNAs. These antisense transcripts contain molecules with a remarkable size range variation from 38 to 6348 base pairs in length. The genome of the type strain B. licheniformis DSM13 was completely reannotated using data obtained from RNA-Seq analyses and from public databases. Conclusion The hereby generated data-sets represent a solid amount of knowledge on the dynamic transcriptional activities during the investigated fermentation stages. The identified regulatory elements enable research on the understanding and the optimization of crucial metabolic activities during a productive fermentation of Bacillus licheniformis strains. PMID:24079885

  12. Feature extraction and recognition of epileptiform activity in EEG by combining PCA with ApEn.

    PubMed

    Wang, Chunmei; Zou, Junzhong; Zhang, Jian; Wang, Min; Wang, Rubin

    2010-09-01

    This paper proposes a new method for feature extraction and recognition of epileptiform activity in EEG signals. The method improves feature extraction speed of epileptiform activity without reducing recognition rate. Firstly, Principal component analysis (PCA) is applied to the original EEG for dimension reduction and to the decorrelation of epileptic EEG and normal EEG. Then discrete wavelet transform (DWT) combined with approximate entropy (ApEn) is performed on epileptic EEG and normal EEG, respectively. At last, Neyman-Pearson criteria are applied to classify epileptic EEG and normal ones. The main procedure is that the principle component of EEG after PCA is decomposed into several sub-band signals using DWT, and ApEn algorithm is applied to the sub-band signals at different wavelet scales. Distinct difference is found between the ApEn values of epileptic and normal EEG. The method allows recognition of epileptiform activities and discriminates them from the normal EEG. The algorithm performs well at epileptiform activity recognition in the clinic EEG data and offers a flexible tool that is intended to be generalized to the simultaneous recognition of many waveforms in EEG. PMID:21886676

  13. Feature extraction and recognition of epileptiform activity in EEG by combining PCA with ApEn

    PubMed Central

    Zou, Junzhong; Zhang, Jian; Wang, Min; Wang, Rubin

    2010-01-01

    This paper proposes a new method for feature extraction and recognition of epileptiform activity in EEG signals. The method improves feature extraction speed of epileptiform activity without reducing recognition rate. Firstly, Principal component analysis (PCA) is applied to the original EEG for dimension reduction and to the decorrelation of epileptic EEG and normal EEG. Then discrete wavelet transform (DWT) combined with approximate entropy (ApEn) is performed on epileptic EEG and normal EEG, respectively. At last, Neyman–Pearson criteria are applied to classify epileptic EEG and normal ones. The main procedure is that the principle component of EEG after PCA is decomposed into several sub-band signals using DWT, and ApEn algorithm is applied to the sub-band signals at different wavelet scales. Distinct difference is found between the ApEn values of epileptic and normal EEG. The method allows recognition of epileptiform activities and discriminates them from the normal EEG. The algorithm performs well at epileptiform activity recognition in the clinic EEG data and offers a flexible tool that is intended to be generalized to the simultaneous recognition of many waveforms in EEG. PMID:21886676

  14. Promoting Metacognition in First Year Anatomy Laboratories Using Plasticine Modeling and Drawing Activities: A Pilot Study of the "Blank Page" Technique

    ERIC Educational Resources Information Center

    Naug, Helen L.; Colson, Natalie J.; Donner, Daniel G.

    2011-01-01

    Many first year students of anatomy and physiology courses demonstrate an inability to self-regulate their learning. To help students increase their awareness of their own learning in a first year undergraduate anatomy course, we piloted an exercise that incorporated the processes of (1) active learning: drawing and plasticine modeling and (2)…

  15. Geomorphological features of active tectonics and ongoing seismicity of northeastern Kumaun Himalaya, Uttarakhand, India

    NASA Astrophysics Data System (ADS)

    Pathak, Vivekanand; Pant, Charu C.; Darmwal, Gopal Singh

    2015-08-01

    The northeastern part of Kumaun Lesser Himalaya, Uttarakhand, India, lying between the rupture zones of 1905, Kangra and 1934, Bihar-Nepal earthquakes and known as `central seismic gap' is a segment of an active fault known to produce significant earthquakes and has not slipped in an unusually long time when compared to other segments. The studied section forms a part of this seismic gap and is seismically an active segment of the Himalayan arc, as compared to the remaining part of the Kumaun Lesser Himalaya and it is evident by active geomorphological features and seismicity data. The geomorphological features of various river valley transects suggest that the region had a history of tectonic rejuvenation which is testified by the deposition of various levels of terraces and their relative uplift, shifting and ponding of river channels, uplifted potholes, triangular facets on fault planes, fault scarps, etc. Further, the seismic data of five-station digital telemetered seismic network along with two stand alone systems show the distribution of earthquakes in or along the analyzed fault transects. It is observed that the microseismic earthquakes (magnitude 1.0-3.0) frequently occur in the region and hypocenters of these earthquakes are confined to shallow depths (10-20 km), with low stress drop values (1.0-10 bar) and higher peak ground velocity (PGV). The cluster of events is observed in the region, sandwiched between the Berinag Thrust (BT) in south and Main Central Thrust (MCT) in north. The occurrences of shallow focus earthquakes and the surface deformational features in the different river valley transect indicates that the region is undergoing neotectonic rejuvenation. In absence of chronology of the deposits it is difficult to relate it with extant seismicity, but from the geomorphic and seismic observations it may be concluded that the region is still tectonically active. The information would be very important in identifying the areas of hazard prone and

  16. Identifying Key Features of Effective Active Learning: The Effects of Writing and Peer Discussion

    PubMed Central

    Pangle, Wiline M.; Wyatt, Kevin H.; Powell, Karli N.; Sherwood, Rachel E.

    2014-01-01

    We investigated some of the key features of effective active learning by comparing the outcomes of three different methods of implementing active-learning exercises in a majors introductory biology course. Students completed activities in one of three treatments: discussion, writing, and discussion + writing. Treatments were rotated weekly between three sections taught by three different instructors in a full factorial design. The data set was analyzed by generalized linear mixed-effect models with three independent variables: student aptitude, treatment, and instructor, and three dependent (assessment) variables: change in score on pre- and postactivity clicker questions, and coding scores on in-class writing and exam essays. All independent variables had significant effects on student performance for at least one of the dependent variables. Students with higher aptitude scored higher on all assessments. Student scores were higher on exam essay questions when the activity was implemented with a writing component compared with peer discussion only. There was a significant effect of instructor, with instructors showing different degrees of effectiveness with active-learning techniques. We suggest that individual writing should be implemented as part of active learning whenever possible and that instructors may need training and practice to become effective with active learning. PMID:25185230

  17. Identifying key features of effective active learning: the effects of writing and peer discussion.

    PubMed

    Linton, Debra L; Pangle, Wiline M; Wyatt, Kevin H; Powell, Karli N; Sherwood, Rachel E

    2014-01-01

    We investigated some of the key features of effective active learning by comparing the outcomes of three different methods of implementing active-learning exercises in a majors introductory biology course. Students completed activities in one of three treatments: discussion, writing, and discussion + writing. Treatments were rotated weekly between three sections taught by three different instructors in a full factorial design. The data set was analyzed by generalized linear mixed-effect models with three independent variables: student aptitude, treatment, and instructor, and three dependent (assessment) variables: change in score on pre- and postactivity clicker questions, and coding scores on in-class writing and exam essays. All independent variables had significant effects on student performance for at least one of the dependent variables. Students with higher aptitude scored higher on all assessments. Student scores were higher on exam essay questions when the activity was implemented with a writing component compared with peer discussion only. There was a significant effect of instructor, with instructors showing different degrees of effectiveness with active-learning techniques. We suggest that individual writing should be implemented as part of active learning whenever possible and that instructors may need training and practice to become effective with active learning. PMID:25185230

  18. Market study: Tactile paging system

    NASA Technical Reports Server (NTRS)

    1977-01-01

    A market survey was conducted regarding the commercialization potential and key market factors relevant to a tactile paging system for deaf-blind people. The purpose of the tactile paging system is to communicate to the deaf-blind people in an institutional environment. The system consists of a main console and individual satellite wrist units. The console emits three signals by telemetry to the wrist com (receiving unit) which will measure approximately 2 x 4 x 3/4 inches and will be fastened to the wrist by a strap. The three vibration signals are fire alarm, time period indication, and a third signal which will alert the wearer of the wrist com to the fact that the pin on the top of the wrist is emitting a morse coded message. The Morse code message can be felt and recognized with the finger.

  19. Comparison of the surface features of two wood-based activated carbons

    SciTech Connect

    Salame, I.I.; Bandosz, T.J.

    2000-02-01

    The surface features of two carbons of wood origin were compared. One sample was manufactured using phosphoric acid activation and the other using potassium hydroxide activation. To check the susceptibility to oxidation and the stability of the porous structure, the samples were oxidized with ammonium persulfate. Structural properties of carbons and their oxidized counterparts were determined using sorption of nitrogen. Surface acidity was evaluated using Boehm titration, potentiometric titration, inverse gas chromatography, and diffuse reflectance FTIR. It was demonstrated that, despite the same wood origin, the carbons significantly differ in their pore structure and surface chemistry. The carbon obtained using KOH activation is homogeneously microporous with high surface area around 2,300 m{sup 2}/g (BET). On the other hand, the carbon manufactured using phosphoric acid contains a high volume of mesopores and its surface area is significantly lower. The carbons also differ in their surface chemistry and susceptibility to oxidation.

  20. Distinctive microstructural features of aged sodium silicate-activated slag concretes

    SciTech Connect

    San Nicolas, Rackel; Bernal, Susan A.; Mejía de Gutiérrez, Ruby; Deventer, Jannie S.J. van; Provis, John L.

    2014-11-15

    Electron microscopic characterisation of 7-year old alkali-activated blast-furnace slag concretes enabled the identification of distinct microstructural features, providing insight into the mechanisms by which these materials evolve over time. Backscattered electron images show the formation of Liesegang-type ring formations, suggesting that the reaction at advanced age is likely to follow an Oswald supersaturation–nucleation–depletion cycle. Segregation of Ca-rich veins, related to the formation of Ca(OH){sub 2}, is observed in microcracked regions due to the ongoing reaction between the pore solution and available calcium from remnant slag grains. A highly dense and uniform interfacial transition zone is identified between siliceous aggregate particles and the alkali activated slag binders, across the concretes assessed. Alkali-activated slag concretes retain a highly dense and stable microstructure at advanced ages, where any microcracks induced at early ages seem to be partially closing, and the remnant slag grains continue reacting.

  1. In re LePage.

    PubMed

    2001-01-01

    Court Decision: 18 Pacific Reporter, 3d Series 1177; 2001 Mar 8 (date of decision). The Supreme Court of Wyoming held that the state Department of Health was not authorized to inquire about the sincerity of a mother's religious beliefs when determining whether her daughter was exempt from a public school immunization requirement. Susan LePage submitted a request to the Department of Health seeking to exempt her daughter from receiving the hepatitis B vaccination. The Department of Health inquired into the sincerity of LePage's religious beliefs against vaccination and determined that her objections were of a personal or philosophical nature and not on religious grounds. The Department of Health denied LePage's request. The Supreme Court of Wyoming held that state law requires the Department of Health to grant an exemption upon the submission of a written objection and does not allow the Department of Health to make an inquiry into the sincerity of the requestor's religious beliefs. The court balanced a valid state interest in protecting schoolchildren from disease with the relatively low number of requests for exemption and its confidence in parents to make decisions in the best interest of their children's physical and spiritual health. Since there was no justification within the statute to allow a religious inquiry, the court held that the Department of Health had exceeded its authority with LePage. Furthermore, state law did not require a religious waiver to exempt a child from this particular vaccine. The lower court's holding was reversed. PMID:16479706

  2. Planetary Photojournal Home Page Graphic

    NASA Technical Reports Server (NTRS)

    2004-01-01

    This image is an unannotated version of the Planetary Photojournal Home Page graphic. This digital collage contains a highly stylized rendition of our solar system and points beyond. As this graphic was intended to be used as a navigation aid in searching for data within the Photojournal, certain artistic embellishments have been added (color, location, etc.). Several data sets from various planetary and astronomy missions were combined to create this image.

  3. Photojournal Home Page Graphic 2007

    NASA Technical Reports Server (NTRS)

    2008-01-01

    This image is an unannotated version of the Photojournal Home Page graphic released in October 2007. This digital collage contains a highly stylized rendition of our solar system and points beyond. As this graphic was intended to be used as a navigation aid in searching for data within the Photojournal, certain artistic embellishments have been added (color, location, etc.). Several data sets from various planetary and astronomy missions were combined to create this image.

  4. Music-induced emotions can be predicted from a combination of brain activity and acoustic features.

    PubMed

    Daly, Ian; Williams, Duncan; Hallowell, James; Hwang, Faustina; Kirke, Alexis; Malik, Asad; Weaver, James; Miranda, Eduardo; Nasuto, Slawomir J

    2015-12-01

    It is widely acknowledged that music can communicate and induce a wide range of emotions in the listener. However, music is a highly-complex audio signal composed of a wide range of complex time- and frequency-varying components. Additionally, music-induced emotions are known to differ greatly between listeners. Therefore, it is not immediately clear what emotions will be induced in a given individual by a piece of music. We attempt to predict the music-induced emotional response in a listener by measuring the activity in the listeners electroencephalogram (EEG). We combine these measures with acoustic descriptors of the music, an approach that allows us to consider music as a complex set of time-varying acoustic features, independently of any specific music theory. Regression models are found which allow us to predict the music-induced emotions of our participants with a correlation between the actual and predicted responses of up to r=0.234,p<0.001. This regression fit suggests that over 20% of the variance of the participant's music induced emotions can be predicted by their neural activity and the properties of the music. Given the large amount of noise, non-stationarity, and non-linearity in both EEG and music, this is an encouraging result. Additionally, the combination of measures of brain activity and acoustic features describing the music played to our participants allows us to predict music-induced emotions with significantly higher accuracies than either feature type alone (p<0.01). PMID:26544602

  5. Heap/stack guard pages using a wakeup unit

    SciTech Connect

    Gooding, Thomas M; Satterfield, David L; Steinmacher-Burow, Burkhard

    2014-04-29

    A method and system for providing a memory access check on a processor including the steps of detecting accesses to a memory device including level-1 cache using a wakeup unit. The method includes invalidating level-1 cache ranges corresponding to a guard page, and configuring a plurality of wakeup address compare (WAC) registers to allow access to selected WAC registers. The method selects one of the plurality of WAC registers, and sets up a WAC register related to the guard page. The method configures the wakeup unit to interrupt on access of the selected WAC register. The method detects access of the memory device using the wakeup unit when a guard page is violated. The method generates an interrupt to the core using the wakeup unit, and determines the source of the interrupt. The method detects the activated WAC registers assigned to the violated guard page, and initiates a response.

  6. Monocyte activation is a feature of common variable immunodeficiency irrespective of plasma lipopolysaccharide levels

    PubMed Central

    Barbosa, R R; Silva, S P; Silva, S L; Tendeiro, R; Melo, A C; Pedro, E; Barbosa, M P; Santos, M C P; Victorino, R M M; Sousa, A E

    2012-01-01

    Common variable immunodeficiency disorders (CVID), the most frequent cause of symptomatic primary immunodeficiency, are defined by impaired antibody production. Notwithstanding, T cell activation and granulomatous manifestations represent the main causes of CVID morbidity even in patients receiving immunoglobulin (Ig) G replacement therapy. Additionally, gut pathology is a frequent feature of CVID. In this study, we investigated monocyte imbalances and their possible relationship with increased microbial translocation in CVID patients. Monocyte subsets were defined according to CD14 and CD16 expression levels and evaluated in terms of human leucocyte antigen D-related (HLA-DR), CD86 and programmed death-1 molecule ligand 1 (PD-L1) expression by flow cytometry, in parallel with the quantification of plasma lipopolysaccharide (LPS) and serum levels of soluble CD14 (sCD14), LPS-binding protein (LBP) and anti-LPS antibodies. CVID patients (n = 31) featured significantly increased levels of serum sCD14 and an expansion of CD14brightCD16+ monocytes in direct correlation with T cell and B cell activation, the latter illustrated by the frequency of the CD21lowCD38low subset. Such alterations were not observed in patients lacking B cells due to congenital agammaglobulinaemia (n = 4). Moreover, we found no significant increase in circulating LPS or LBP levels in CVID patients, together with a relative preservation of serum anti-LPS antibodies, in agreement with their presence in commercial IgG preparations. In conclusion, CVID was associated with monocyte imbalances that correlated directly with T cell activation markers and with B cell imbalances, without an association with plasma LPS levels. The heightened monocyte activated state observed in CVID may represent an important target for complementary therapeutic strategies. PMID:22861366

  7. Joint Spatial-Spectral Feature Space Clustering for Speech Activity Detection from ECoG Signals

    PubMed Central

    Kanas, Vasileios G.; Mporas, Iosif; Benz, Heather L.; Sgarbas, Kyriakos N.; Bezerianos, Anastasios; Crone, Nathan E.

    2014-01-01

    Brain machine interfaces for speech restoration have been extensively studied for more than two decades. The success of such a system will depend in part on selecting the best brain recording sites and signal features corresponding to speech production. The purpose of this study was to detect speech activity automatically from electrocorticographic signals based on joint spatial-frequency clustering of the ECoG feature space. For this study, the ECoG signals were recorded while a subject performed two different syllable repetition tasks. We found that the optimal frequency resolution to detect speech activity from ECoG signals was 8 Hz, achieving 98.8% accuracy by employing support vector machines (SVM) as a classifier. We also defined the cortical areas that held the most information about the discrimination of speech and non-speech time intervals. Additionally, the results shed light on the distinct cortical areas associated with the two syllable repetition tasks and may contribute to the development of portable ECoG-based communication. PMID:24658248

  8. The energy balance and pressure in the solar transition zone for network and active region features

    NASA Technical Reports Server (NTRS)

    Nicolas, K. R.; Bartoe, J.-D. F.; Brueckner, G. E.; Vanhoosier, M. E.

    1979-01-01

    The electron pressure and energy balance in the solar transition zone are determined for about 125 network and active region features on the basis of high spectral and spatial resolution extreme ultraviolet spectra. Si III line intensity ratios obtained from the Naval Research Laboratory high-resolution telescope and spectrograph during a rocket flight are used as diagnostics of electron density and pressure for solar features near 3.5 x 10 to the 4th K. Observed ratios are compared with the calculated dependence of the 1301 A/1312 A and 1301 A/1296 A line intensity ratios on electron density, temperature and pressure. Electron densities ranging from 2 x 10 to the 10th/cu cm to 10 to the 12th/cu cm and active region pressures from 3 x 10 to the 15th to 10 to the 16th/cu cm K are obtained. Energy balance calculations reveal the balance of the divergence of the conductive flux and turbulent energy dissipation by radiative energy losses in a plane-parallel homogeneous transition zone (fill factor of 1), and an energy source requirement for a cylindrical zone geometry (fill factor less than 0.04).

  9. THE INTRINSIC VALUE OF HFO FEATURES AS A BIOMARKER OF EPILEPTIC ACTIVITY

    PubMed Central

    Gliske, Stephen V.; Stacey, William C.; Moon, Kevin R.; Hero, Alfred O.

    2016-01-01

    High frequency oscillations (HFOs) are a promising biomarker of epileptic brain tissue and activity. HFOs additionally serve as a prototypical example of challenges in the analysis of discrete events in high-temporal resolution, intracranial EEG data. Two primary challenges are 1) dimensionality reduction, and 2) assessing feasibility of classification. Dimensionality reduction assumes that the data lie on a manifold with dimension less than that of the features space. However, previous HFO analysis have assumed a linear manifold, global across time, space (i.e. recording electrode/channel), and individual patients. Instead, we assess both a) whether linear methods are appropriate and b) the consistency of the manifold across time, space, and patients. We also estimate bounds on the Bayes classification error to quantify the distinction between two classes of HFOs (those occurring during seizures and those occurring due to other processes). This analysis provides the foundation for future clinical use of HFO features and guides the analysis for other discrete events, such as individual action potentials or multi-unit activity.

  10. Genomic features of uncultured methylotrophs in activated-sludge microbiomes grown under different enrichment procedures

    PubMed Central

    Fujinawa, Kazuki; Asai, Yusuke; Miyahara, Morio; Kouzuma, Atsushi; Abe, Takashi; Watanabe, Kazuya

    2016-01-01

    Methylotrophs are organisms that are able to grow on C1 compounds as carbon and energy sources. They play important roles in the global carbon cycle and contribute largely to industrial wastewater treatment. To identify and characterize methylotrophs that are involved in methanol degradation in wastewater-treatment plants, methanol-fed activated-sludge (MAS) microbiomes were subjected to phylogenetic and metagenomic analyses, and genomic features of dominant methylotrophs in MAS were compared with those preferentially grown in laboratory enrichment cultures (LECs). These analyses consistently indicate that Hyphomicrobium plays important roles in MAS, while Methylophilus occurred predominantly in LECs. Comparative analyses of bin genomes reconstructed for the Hyphomicrobium and Methylophilus methylotrophs suggest that they have different C1-assimilation pathways. In addition, function-module analyses suggest that their cell-surface structures are different. Comparison of the MAS bin genome with genomes of closely related Hyphomicrobium isolates suggests that genes unnecessary in MAS (for instance, genes for anaerobic respiration) have been lost from the genome of the dominant methylotroph. We suggest that genomic features and coded functions in the MAS bin genome provide us with insights into how this methylotroph adapts to activated-sludge ecosystems. PMID:27221669

  11. Genomic features of uncultured methylotrophs in activated-sludge microbiomes grown under different enrichment procedures.

    PubMed

    Fujinawa, Kazuki; Asai, Yusuke; Miyahara, Morio; Kouzuma, Atsushi; Abe, Takashi; Watanabe, Kazuya

    2016-01-01

    Methylotrophs are organisms that are able to grow on C1 compounds as carbon and energy sources. They play important roles in the global carbon cycle and contribute largely to industrial wastewater treatment. To identify and characterize methylotrophs that are involved in methanol degradation in wastewater-treatment plants, methanol-fed activated-sludge (MAS) microbiomes were subjected to phylogenetic and metagenomic analyses, and genomic features of dominant methylotrophs in MAS were compared with those preferentially grown in laboratory enrichment cultures (LECs). These analyses consistently indicate that Hyphomicrobium plays important roles in MAS, while Methylophilus occurred predominantly in LECs. Comparative analyses of bin genomes reconstructed for the Hyphomicrobium and Methylophilus methylotrophs suggest that they have different C1-assimilation pathways. In addition, function-module analyses suggest that their cell-surface structures are different. Comparison of the MAS bin genome with genomes of closely related Hyphomicrobium isolates suggests that genes unnecessary in MAS (for instance, genes for anaerobic respiration) have been lost from the genome of the dominant methylotroph. We suggest that genomic features and coded functions in the MAS bin genome provide us with insights into how this methylotroph adapts to activated-sludge ecosystems. PMID:27221669

  12. Interstellar Initiative Web Page Design

    NASA Technical Reports Server (NTRS)

    Mehta, Alkesh

    1999-01-01

    This summer at NASA/MSFC, I have contributed to two projects: Interstellar Initiative Web Page Design and Lenz's Law Relative Motion Demonstration. In the Web Design Project, I worked on an Outline. The Web Design Outline was developed to provide a foundation for a Hierarchy Tree Structure. The Outline would help design a Website information base for future and near-term missions. The Website would give in-depth information on Propulsion Systems and Interstellar Travel. The Lenz's Law Relative Motion Demonstrator is discussed in this volume by Russell Lee.

  13. Seachable Solar Feature Catalogues in EGSO

    NASA Astrophysics Data System (ADS)

    Zharkova, V. V.; Aboudarham, J.; Zharkov, S. I.; Ipson, S. S.; Benkhalil, A. K.; Fuller, N.

    2004-12-01

    The searchable Solar Feature Catalogues (SFC) developed using automated pattern recognition techniques from digitized solar images are presented. The techniques were applied for detection of sunspots, active regions, filaments and line-on-sight magnetic neutral lines in the automatically standardized full disk solar images in Ca II K1, Ca II K3 and Ha taken at the Meudon Observatory and white light images and magnetograms from SOHO/MDI. The results of automated recognition were verified with the manual synoptic maps and available statistical data that revealed good detection accuracy. Based on the recognized parameters a structured database of the Solar Feature Catalogues was built on a mysql server for every feature and published with various pre-designed search pages on the Bradford University web site. The SFCs with 10 year coverage (1996-2005) is to be used for deeper investigation of the solar activity, activity feature classification and forecast.

  14. 12 CFR 1010.105 - Cover page.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 8 2014-01-01 2014-01-01 false Cover page. 1010.105 Section 1010.105 Banks and Banking BUREAU OF CONSUMER FINANCIAL PROTECTION LAND REGISTRATION (REGULATION J) Reporting Requirements § 1010.105 Cover page. The cover page of the Property Report shall be prepared in accordance with...

  15. 16 CFR 436.3 - Cover page.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Cover page. 436.3 Section 436.3 Commercial Practices FEDERAL TRADE COMMISSION TRADE REGULATION RULES DISCLOSURE REQUIREMENTS AND PROHIBITIONS CONCERNING FRANCHISING Contents of a Disclosure Document § 436.3 Cover page. Begin the disclosure document with a cover page, in the order and form...

  16. A Primer on Developing and Using Course-Related Library Web Pages.

    ERIC Educational Resources Information Center

    Ragains, Patrick

    2001-01-01

    Discusses course-related academic library Web pages and their use in library instruction. Describes course-related Web pages at the University of Nevada-Reno library that are designed on a template that includes main features of the library Web site, subject-specific online indexes and databases, links to electronic journals, and recommended Web…

  17. Frequencies, Laboratory Features, and Granulocyte Activation in Chinese Patients with CALR-Mutated Myeloproliferative Neoplasms

    PubMed Central

    Tian, Ruiyuan; Chang, Jianmei; Li, Jianlan; Tan, Yanhong; Xu, Zhifang; Ren, Fanggang; Zhao, Junxia; Pan, Jie; Zhang, Na; Wang, Xiaojuan; He, Jianxia; Yang, Wanfang; Wang, Hongwei

    2015-01-01

    Somatic mutations in the CALR gene have been recently identified as acquired alterations in myeloproliferative neoplasms (MPNs). In this study, we evaluated mutation frequencies, laboratory features, and granulocyte activation in Chinese patients with MPNs. A combination of qualitative allele-specific polymerase chain reaction and Sanger sequencing was used to detect three driver mutations (i.e., CALR, JAK2V617F, and MPL). CALR mutations were identified in 8.4% of cases with essential thrombocythemia (ET) and 5.3% of cases with primary myelofibrosis (PMF). Moreover, 25% of polycythemia vera, 29.5% of ET, and 48.1% of PMF were negative for all three mutations (JAK2V617F, MPL, and CALR). Compared with those patients with JAK2V617F mutation, CALR-mutated ET patients displayed unique hematological phenotypes, including higher platelet counts, and lower leukocyte counts and hemoglobin levels. Significant differences were not found between Chinese PMF patients with mutants CALR and JAK2V617F in terms of laboratory features. Interestingly, patients with CALR mutations showed markedly decreased levels of leukocyte alkaline phosphatase (LAP) expression, whereas those with JAK2V617F mutation presented with elevated levels. Overall, a lower mutant rate of CALR gene and a higher triple-negative rate were identified in the cohort of Chinese patients with MPNs. This result indicates that an undiscovered mutant gene may have a significant role in these patients. Moreover, these pathological features further imply that the disease biology varies considerably between mutants CALR and JAK2V617F. PMID:26375990

  18. Microscopic and mesoscopic structural features of an activated carbon sample, prepared from sorghum via activation by phosphoric acid

    SciTech Connect

    Temleitner, László; Pusztai, László; Rubio-Arroyo, Manuel F.; Aguilar-López, Sergio; Pizio, Orest

    2012-12-15

    Graphical abstract: Display Omitted Highlights: ► Preparation of a new activated carbon sample from sorghum. ► Characterization by adsorption/desorption methods. ► Determination of the structure by synchrotron X-ray diffraction. ► The sample is amorphous and contains distorted graphene fragments. ► A characteristic nanoscale distance is established from the radial distribution function. -- Abstract: An acidic chemical activation procedure has been used for preparing activated carbon with a surface area exceeding 1000 m{sup 2}/g from sorghum. In order to reveal structural features, synchrotron X-ray diffraction measurements have been performed. The structure of the material has been characterized by the total scattering structure factor and the radial distribution function describing short-range arrangement of atoms at distances of the order of a few atomic diameters as well as correlations at a longer scale, of the order of nanometers. The atomic arrangement has been found to be consistent with that of amorphous graphite-like carbon. As far as the mesoscopic structure is concerned, the presence of a characteristic distance is suggested on the basis of the clear nanometer scale oscillations of the radial distribution function, which distance may be assigned as the mesopore size in the material. It is suggested that the approach devized here may later be applied routinely for other activated carbon samples, too, for characterizing atomic and nanoscale order simultaneously.

  19. Unsupervised Feature Learning Improves Prediction of Human Brain Activity in Response to Natural Images

    PubMed Central

    Güçlü, Umut; van Gerven, Marcel A. J.

    2014-01-01

    Encoding and decoding in functional magnetic resonance imaging has recently emerged as an area of research to noninvasively characterize the relationship between stimulus features and human brain activity. To overcome the challenge of formalizing what stimulus features should modulate single voxel responses, we introduce a general approach for making directly testable predictions of single voxel responses to statistically adapted representations of ecologically valid stimuli. These representations are learned from unlabeled data without supervision. Our approach is validated using a parsimonious computational model of (i) how early visual cortical representations are adapted to statistical regularities in natural images and (ii) how populations of these representations are pooled by single voxels. This computational model is used to predict single voxel responses to natural images and identify natural images from stimulus-evoked multiple voxel responses. We show that statistically adapted low-level sparse and invariant representations of natural images better span the space of early visual cortical representations and can be more effectively exploited in stimulus identification than hand-designed Gabor wavelets. Our results demonstrate the potential of our approach to better probe unknown cortical representations. PMID:25101625

  20. Features of the electronic structure of the active center of an HbS molecule

    NASA Astrophysics Data System (ADS)

    Novoselov, D. Yu.; Korotin, Dm. M.; Anisimov, V. I.

    2016-01-01

    Features of the electronic structure of the nonprotein part of the mutant form of the human hemoglobin molecule, HbS, are studied along with the magnetic state of the iron ion that is the "nucleus" of the active center of the molecule. It is found that the mutant form of the HbS molecule differs from a normal hemoglobin molecule by the distortion of the local environment of the iron ion, which changes the energy level splitting by a crystal field. As a result of ab initio calculations, the magnetic transition in the iron atom from the high-spin state to the low-spin state upon the addition of molecular oxygen to hemoglobin molecule is reproduced. It is established for the first time that a change in the crystal and electronic structure of the active center as a result of a mutation can lead to a substantial change in the energy of the bond between the active center of the hemoglobin molecule and an oxygen molecule.

  1. Medicinal properties of mangiferin, structural features, derivative synthesis, pharmacokinetics and biological activities.

    PubMed

    Benard, Outhiriaradjou; Chi, Yuling

    2015-01-01

    The identification of biologically active and potentially therapeutically useful pharmacophores from natural products has been a long-term focus in the pharmaceutical industry. The recent emergence of a worldwide obesity and Type II diabetes epidemic has increased focus upon small molecules that can modulate energy metabolism, insulin sensitivity and fat biology. Interesting preliminary work done on mangiferin (MGF), the predominant constituent of extracts of the mango plant Mangifera indica L., portends potential for this pharmacophore as a novel parent compound for treating metabolic disorders. MGF is comprised of a C-glucosylated xanthone. Owing to the xanthone chemical structure, MGF has a redox active aromatic system and has antioxidant properties. MGF exerts varied and impressive metabolic effects in animals, improving metabolic disorders. For example we have discovered that MGF is a novel activator of the mammalian pyruvate dehydrogenase complex, leading to enhancement of carbohydrate utilization in oxidative metabolism, and leading to increased insulin sensitivity in animal models of obesity and insulin resistance. In addition, recent unbiased proteomics studies revealed that MGF upregulates proteins pivotal for mitochondrial bioenergetics and downregulates proteins controlling de novo lipogenesis in liver, helping to explain protective effects of MGF in prevention of liver steatosis. Several chemical studies have achieved synthesis of MGF, suggesting possible synthetic strategies to alter its chemical structure for development of structure-activity relationship (SAR) information. Ultimately, chemical derivatization studies could lead to the eventual development of novel therapeutics based upon the parent pharmacophore structure. Here we provide comprehensive review on chemical features of MGF, synthesis of its derivatives, its pharmacokinetics and biological activities. PMID:25827900

  2. Image sensor innovations for low light levels with active imaging features

    NASA Astrophysics Data System (ADS)

    Powell, Gareth H.; Fereyre, Pierre

    2015-02-01

    Advances in CMOS imaging enable image capture at lower light levels. Color detection is also possible where human vision becomes less sensitive in night conditions. In daytime conditions, there are a number of climatic conditions such as rain, fog, snow or smoke etc. that render traditional `intelligent' outdoor cameras that perform various forms of detection and identification tasks relatively ineffective. It has been proven that an adapted five transistor pixel CMOS sensor can perform range-gated active imaging that extends considerably the usability of intelligent cameras in the most difficult conditions. This paper discusses advanced state of the art image sensors with embedded features, with emphasis on the everimportant size, weight, power and cost benefits and discusses the new applications that are enabled.

  3. Feature Selection for Wearable Smartphone-Based Human Activity Recognition with Able bodied, Elderly, and Stroke Patients

    PubMed Central

    2015-01-01

    Human activity recognition (HAR), using wearable sensors, is a growing area with the potential to provide valuable information on patient mobility to rehabilitation specialists. Smartphones with accelerometer and gyroscope sensors are a convenient, minimally invasive, and low cost approach for mobility monitoring. HAR systems typically pre-process raw signals, segment the signals, and then extract features to be used in a classifier. Feature selection is a crucial step in the process to reduce potentially large data dimensionality and provide viable parameters to enable activity classification. Most HAR systems are customized to an individual research group, including a unique data set, classes, algorithms, and signal features. These data sets are obtained predominantly from able-bodied participants. In this paper, smartphone accelerometer and gyroscope sensor data were collected from populations that can benefit from human activity recognition: able-bodied, elderly, and stroke patients. Data from a consecutive sequence of 41 mobility tasks (18 different tasks) were collected for a total of 44 participants. Seventy-six signal features were calculated and subsets of these features were selected using three filter-based, classifier-independent, feature selection methods (Relief-F, Correlation-based Feature Selection, Fast Correlation Based Filter). The feature subsets were then evaluated using three generic classifiers (Naïve Bayes, Support Vector Machine, j48 Decision Tree). Common features were identified for all three populations, although the stroke population subset had some differences from both able-bodied and elderly sets. Evaluation with the three classifiers showed that the feature subsets produced similar or better accuracies than classification with the entire feature set. Therefore, since these feature subsets are classifier-independent, they should be useful for developing and improving HAR systems across and within populations. PMID:25885272

  4. Feature selection for wearable smartphone-based human activity recognition with able bodied, elderly, and stroke patients.

    PubMed

    Capela, Nicole A; Lemaire, Edward D; Baddour, Natalie

    2015-01-01

    Human activity recognition (HAR), using wearable sensors, is a growing area with the potential to provide valuable information on patient mobility to rehabilitation specialists. Smartphones with accelerometer and gyroscope sensors are a convenient, minimally invasive, and low cost approach for mobility monitoring. HAR systems typically pre-process raw signals, segment the signals, and then extract features to be used in a classifier. Feature selection is a crucial step in the process to reduce potentially large data dimensionality and provide viable parameters to enable activity classification. Most HAR systems are customized to an individual research group, including a unique data set, classes, algorithms, and signal features. These data sets are obtained predominantly from able-bodied participants. In this paper, smartphone accelerometer and gyroscope sensor data were collected from populations that can benefit from human activity recognition: able-bodied, elderly, and stroke patients. Data from a consecutive sequence of 41 mobility tasks (18 different tasks) were collected for a total of 44 participants. Seventy-six signal features were calculated and subsets of these features were selected using three filter-based, classifier-independent, feature selection methods (Relief-F, Correlation-based Feature Selection, Fast Correlation Based Filter). The feature subsets were then evaluated using three generic classifiers (Naïve Bayes, Support Vector Machine, j48 Decision Tree). Common features were identified for all three populations, although the stroke population subset had some differences from both able-bodied and elderly sets. Evaluation with the three classifiers showed that the feature subsets produced similar or better accuracies than classification with the entire feature set. Therefore, since these feature subsets are classifier-independent, they should be useful for developing and improving HAR systems across and within populations. PMID:25885272

  5. Combining EEG Microstates with fMRI Structural Features for Modeling Brain Activity.

    PubMed

    Michalopoulos, Kostas; Bourbakis, Nikolaos

    2015-12-01

    Combining information from Electroencephalography (EEG) and Functional Magnetic Resonance Imaging (fMRI) has been a topic of increased interest recently. The main advantage of the EEG is its high temporal resolution, in the scale of milliseconds, while the main advantage of fMRI is the detection of functional activity with good spatial resolution. The advantages of each modality seem to complement each other, providing better insight in the neuronal activity of the brain. The main goal of combining information from both modalities is to increase the spatial and the temporal localization of the underlying neuronal activity captured by each modality. This paper presents a novel technique based on the combination of these two modalities (EEG, fMRI) that allow a better representation and understanding of brain activities in time. EEG is modeled as a sequence of topographies, based on the notion of microstates. Hidden Markov Models (HMMs) were used to model the temporal evolution of the topography of the average Event Related Potential (ERP). For each model the Fisher score of the sequence is calculated by taking the gradient of the trained model parameters. The Fisher score describes how this sequence deviates from the learned HMM. Canonical Partial Least Squares (CPLS) were used to decompose the two datasets and fuse the EEG and fMRI features. In order to test the effectiveness of this method, the results of this methodology were compared with the results of CPLS using the average ERP signal of a single channel. The presented methodology was able to derive components that co-vary between EEG and fMRI and present significant differences between the two tasks. PMID:26584584

  6. Using Citizen Scientists to Gather, Analyze, and Disseminate Information About Neighborhood Features That Affect Active Living.

    PubMed

    Winter, Sandra J; Goldman Rosas, Lisa; Padilla Romero, Priscilla; Sheats, Jylana L; Buman, Matthew P; Baker, Cathleen; King, Abby C

    2016-10-01

    Many Latinos are insufficiently active, partly due to neighborhoods with little environmental support for physical activity. Multi-level approaches are needed to create health-promoting neighborhoods in disadvantaged communities. Participant "citizen scientists" were adolescent (n = 10, mean age = 12.8 ± 0.6 years) and older adult (n = 10, mean age = 71.3 ± 6.5 years), low income Latinos in North Fair Oaks, California. Citizen scientists conducted environmental assessments to document perceived barriers to active living using the Stanford Healthy Neighborhood Discovery Tool, which records GPS-tracked walking routes, photographs, audio narratives, and survey responses. Using a community-engaged approach, citizen scientists subsequently attended a community meeting to engage in advocacy training, review assessment data, prioritize issues to address and brainstorm potential solutions and partners. Citizen scientists each conducted a neighborhood environmental assessment and recorded 366 photographs and audio narratives. Adolescents (n = 4), older adults (n = 7) and community members (n = 4) collectively identified reducing trash and improving personal safety and sidewalk quality as the priority issues to address. Three adolescent and four older adult citizen scientists volunteered to present study findings to key stakeholders. This study demonstrated that with minimal training, low-income, Latino adolescent and older adult citizen scientists can: (1) use innovative technology to gather information about features of their neighborhood environment that influence active living, (2) analyze their information and identify potential solutions, and (3) engage with stakeholders to advocate for the development of healthier neighborhoods. PMID:26184398

  7. "I didn't know her, but…": parasocial mourning of mediated deaths on Facebook RIP pages

    NASA Astrophysics Data System (ADS)

    Klastrup, Lisbeth

    2015-04-01

    This article examines the use of six Danish "Rest in Peace" or (RIP) memorial pages. The article focuses on the relation between news media and RIP page use, in relation to general communicative practices on these pages. Based on an analysis of press coverage of the deaths of six young people and a close analysis of 1,015 comments extracted from the RIP pages created to memorialize them, it is shown that their deaths attracted considerable media attention, as did the RIP pages themselves. Comment activity seem to reflect the news stories in the way the commenters refer to the context of death and the emotional distress they experience, but mainly comments on the RIP pages are conventional expressions of sympathy and "RIP" wishes. The article concludes that public RIP pages might be understood as virtual spontaneous shrines, affording an emerging practice of "RIP-ing."

  8. An approach to the segmentation of multi-page document flow using binary classification

    NASA Astrophysics Data System (ADS)

    Agin, Onur; Ulas, Cagdas; Ahat, Mehmet; Bekar, Can

    2015-03-01

    In this paper, we present a method for segmentation of document page flow applied to heterogeneous real bank documents. The approach is based on the content of images and it also incorporates font based features inside the documents. Our method involves a bag of visual words (BoVW) model on the designed image based feature descriptors and a novel approach to combine the consecutive pages of a document into a single feature vector that represents the transition between these pages. The transitions here could be represented by one of the two different classes: continuity of the same document or beginning of a new document. Using the transition feature vectors, we utilize three different binary classifiers to make predictions on the relationship between consecutive pages. Our initial results demonstrate that the proposed method can exhibit promising performance for document flow segmentation at this stage.

  9. Premature skin aging features rescued by inhibition of NADPH oxidase activity in XPC-deficient mice.

    PubMed

    Hosseini, Mohsen; Mahfouf, Walid; Serrano-Sanchez, Martin; Raad, Houssam; Harfouche, Ghida; Bonneu, Marc; Claverol, Stephane; Mazurier, Frederic; Rossignol, Rodrigue; Taieb, Alain; Rezvani, Hamid Reza

    2015-04-01

    Xeroderma pigmentosum type C (XP-C) is characterized mostly by a predisposition to skin cancers and accelerated photoaging, but little is known about premature skin aging in this disease. By comparing young and old mice, we found that the level of progerin and p16(INK4a) expression, β-galactosidase activity, and reactive oxygen species, which increase with age, were higher in young Xpc(-/-) mice than in young Xpc(+/+) ones. The expression level of mitochondrial complexes and mitochondrial functions in the skin of young Xpc(-/-) was as low as in control aged Xpc(+/+)animals. Furthermore, the metabolic profile in young Xpc(-/-) mice resembled that found in aged Xpc(+/+) mice. Furthermore, premature skin aging features in young Xpc(-/-) mice were mostly rescued by inhibition of nicotinamide adenine dinucleotide phosphate oxidase 1 (NOX1) activity by using a NOX1 peptide inhibitor, suggesting that the continuous oxidative stress due to overactivation of NOX1 has a causative role in the underlying pathophysiology. PMID:25437426

  10. Strong Nonadditivity as a Key Structure–Activity Relationship Feature: Distinguishing Structural Changes from Assay Artifacts

    PubMed Central

    2015-01-01

    Nonadditivity in protein–ligand affinity data represents highly instructive structure–activity relationship (SAR) features that indicate structural changes and have the potential to guide rational drug design. At the same time, nonadditivity is a challenge for both basic SAR analysis as well as many ligand-based data analysis techniques such as Free-Wilson Analysis and Matched Molecular Pair analysis, since linear substituent contribution models inherently assume additivity and thus do not work in such cases. While structural causes for nonadditivity have been analyzed anecdotally, no systematic approaches to interpret and use nonadditivity prospectively have been developed yet. In this contribution, we lay the statistical framework for systematic analysis of nonadditivity in a SAR series. First, we develop a general metric to quantify nonadditivity. Then, we demonstrate the non-negligible impact of experimental uncertainty that creates apparent nonadditivity, and we introduce techniques to handle experimental uncertainty. Finally, we analyze public SAR data sets for strong nonadditivity and use recourse to the original publications and available X-ray structures to find structural explanations for the nonadditivity observed. We find that all cases of strong nonadditivity (ΔΔpKi and ΔΔpIC50 > 2.0 log units) with sufficient structural information to generate reasonable hypothesis involve changes in binding mode. With the appropriate statistical basis, nonadditivity analysis offers a variety of new attempts for various areas in computer-aided drug design, including the validation of scoring functions and free energy perturbation approaches, binding pocket classification, and novel features in SAR analysis tools. PMID:25760829

  11. Structural features important for the biological activity of the potassium channel blocking dendrotoxins.

    PubMed Central

    Hollecker, M.; Marshall, D. L.; Harvey, A. L.

    1993-01-01

    1. Dendrotoxins from mamba snake venoms are small proteins that block neuronal K+ channels. In order to investigate structural features associated with their biological activity, partially folded versions of dendrotoxins I and K from black mamba (Dendroaspis polylepis) were prepared by selectively reducing one or more of their three S-S bonds. 2. The modified toxins were tested for ability to compete with 125I-labelled native toxin I to high affinity binding sites on rat brain synaptosomal membranes and for the ability to increase acetylcholine release in a neuromuscular preparation. 3. Binding affinity increased progressively as the toxins folded to the native conformation and the most biologically active of the modified species were those in which only the disulphide bond between residues 14 and 38 was not formed. These intermediates had native-like conformations as determined by circular dichroism but still had about 5-10 times lower affinity than native toxins. 4. Addition of negatively charged groups to block the free sulthydryls at positions 14 and 38 caused a further, marked loss of activity. 5. The results are consistent with the existence of two important regions in the dendrotoxin molecules. The region containing two of the disulphide bonds (around Cys5-Cys55 and Cys30-Cys51) and much of the secondary structure is essential for the binding affinity of the toxins, while the region around Cys14 and Cys38, equivalent to part of the antiprotease site of the homologous protease inhibitor from bovine pancreas (BPTI), plays an important role in the potency of dendrotoxins. PMID:7694758

  12. Structural features important for the biological activity of the potassium channel blocking dendrotoxins.

    PubMed

    Hollecker, M; Marshall, D L; Harvey, A L

    1993-10-01

    1. Dendrotoxins from mamba snake venoms are small proteins that block neuronal K+ channels. In order to investigate structural features associated with their biological activity, partially folded versions of dendrotoxins I and K from black mamba (Dendroaspis polylepis) were prepared by selectively reducing one or more of their three S-S bonds. 2. The modified toxins were tested for ability to compete with 125I-labelled native toxin I to high affinity binding sites on rat brain synaptosomal membranes and for the ability to increase acetylcholine release in a neuromuscular preparation. 3. Binding affinity increased progressively as the toxins folded to the native conformation and the most biologically active of the modified species were those in which only the disulphide bond between residues 14 and 38 was not formed. These intermediates had native-like conformations as determined by circular dichroism but still had about 5-10 times lower affinity than native toxins. 4. Addition of negatively charged groups to block the free sulthydryls at positions 14 and 38 caused a further, marked loss of activity. 5. The results are consistent with the existence of two important regions in the dendrotoxin molecules. The region containing two of the disulphide bonds (around Cys5-Cys55 and Cys30-Cys51) and much of the secondary structure is essential for the binding affinity of the toxins, while the region around Cys14 and Cys38, equivalent to part of the antiprotease site of the homologous protease inhibitor from bovine pancreas (BPTI), plays an important role in the potency of dendrotoxins. PMID:7694758

  13. The luminous polycyclic aromatic hydrocarbon emission features: Applications to high redshift galaxies and active galactic nuclei

    NASA Astrophysics Data System (ADS)

    Shipley, Heath Vernon

    (corrected for attenuation using the mono-chromatic rest-frame 24um emission), with a tight scatter of 0.15 dex. The scatter is comparable to that between SFRs derived from the Paalpha and dust-corrected Halpha emission lines, implying the PAH features may be as accurate a SFR indicator as the Hydrogen recombination lines. Because the PAH features are so bright, our PAH SFR calibration enables an efficient way to measure SFRs in distant galaxies with JWST to SFRs as low as ~10 M; yr-1 to z >~ 2. We use Spitzer/IRS observations of PAH features in lensed star-forming galaxies at 1 < z < 3 to demonstrate the utility of the PAHs to derive SFRs as accurate as those available from Paalpha. Chapter 4 is the application of the PAH SFRs for galaxies with AGN to demonstrate the reliability for studies of the co-evolution of star-formation and SMBH accretion. We present a study of the contribution from star-formation in galaxies of varying AGN activity (from pure star-forming galaxies to quasars) as a function of total IR luminosity using a sample of 220 galaxies. We use mid-IR spectroscopy from the Spitzer/IRS and photometry from the MIPS mum, 70mum and 160mum bands with partial coverage of the sample with the Herschel 160mum band for the quasars. The contribution from star-formation to the total IR luminosity implied by the PAH emission decreases with increasing IR luminosity. We find a similar result to previous studies for the correlation between SFR, i.e. PAH luminosity, and AGN luminosity for quasars of LSF [special characters omitted] for the 11.3mum PAH feature only (which has been shown to be the most reliable PAH feature in the vicinity of AGN). This may indicate the PAH luminosity remains a reliable tracer of the SFR for galaxies with strong AGN contributions (i.e. quasars), as we did not subtract off the AGN component before measuring the SFR from the PAH luminosity.

  14. Activation and maintenance of peripheral semantic features of unambiguous words after right hemisphere brain damage in adults

    PubMed Central

    Tompkins, Connie A.; Fassbinder, Wiltrud; Scharp, Victoria L.; Meigh, Kimberly M.

    2009-01-01

    Background The right cerebral hemisphere (RH) sustains activation of subordinate, secondary, less common, and/or distantly related meanings of words. Much of the pertinent data come from studies of homonyms, but some evidence also suggests that the RH has a unique maintenance function in relation to unambiguous nouns. In a divided visual field priming study, Atchley, Burgess, and Keeney (1999) reported that only left visual field/RH presentation yielded evidence of continuing activation of peripheral semantic features that were incompatible with the most common image or representation of their corresponding nouns (e.g., rotten for “apple”). Activation for weakly related features that were compatible with the dominant representation (e.g., crunchy) was sustained over time regardless of the visual field/hemisphere of initial stimulus input. Several studies report that unilateral right hemisphere brain damage (RHD) in adults affects the RH’s meaning maintenance function, but this work also has centred on homonyms, and/or more recently metonymic and metaphoric polysemous words. Aims The current investigation examined whether RHD deficits in processing secondary and/or distantly related meanings of words, typically observed in studies of homonyms, would extend to peripheral, weakly related semantic features of unambiguous nouns. Methods & Procedures Participants were 28 adults with unilateral RHD from cerebrovascular accident, and 38 adults without brain damage. Participants listened to spoken sentences that ended with an unambiguous noun. Each sentence was followed by a spoken target phoneme string. Targets included peripheral semantic features of the sentence-final noun that were either compatible or incompatible with the dominant mental images of the noun, and were presented at two intervals after that noun. A lexical decision task was used to gauge both the early activation and maintenance of activation for these weakly related semantic features. Outcomes

  15. Mitigating DoS Attacks on the Paging Channel by Efficient Encoding in Page Messages

    NASA Astrophysics Data System (ADS)

    Cai, Liang; Maganis, Gabriel; Zang, Hui; Chen, Hao

    Paging is an important mechanism for network bandwidth efficiency and mobile terminal battery life. It has been widely adopted by mobile networks, such as cellular networks, WiMax, and Mobile IP. Due to certain mechanisms for achieving paging efficiency and the convergence of wireless voice and data networks, the paging channel is vulnerable to inexpensive DoS attacks. To mitigate these attacks, we propose to leverage the knowledge of the user population size, the slotted nature of the paging operation, and the quick paging mechanism to reduce the length of terminal identifiers. In the case of a CDMA2000 system, we can reduce each identifier from 34 bits down to 7 bits, effectively doubling the paging channel capacity. Moreover, our scheme incurs no paging latency, missed pages, or false pages. Using a simulator and data collected from a commercial cellular network, we demonstrate that our scheme doubles the cost for DoS attackers.

  16. Realistic page-turning of electronic books

    NASA Astrophysics Data System (ADS)

    Fan, Chaoran; Li, Haisheng; Bai, Yannan

    2014-01-01

    The booming electronic books (e-books), as an extension to the paper book, are popular with readers. Recently, many efforts are put into the realistic page-turning simulation o f e-book to improve its reading experience. This paper presents a new 3D page-turning simulation approach, which employs piecewise time-dependent cylindrical surfaces to describe the turning page and constructs smooth transition method between time-dependent cylinders. The page-turning animation is produced by sequentially mapping the turning page into the cylinders with different radii and positions. Compared to the previous approaches, our method is able to imitate various effects efficiently and obtains more natural animation of turning page.

  17. Autofluorescence based visualization of proteins from unstained native-PAGE

    NASA Astrophysics Data System (ADS)

    Manjunath, S.; Rao, Bola Sadashiva S.; Satyamoorthy, Kapaettu; Mahato, Krishna Kishore

    2015-03-01

    Proteins are the most diverse and functionally active biomolecules in the living system. In order to understand their diversity and dynamic functionality, visualization in native form without altering structural and functional properties during the separation from the complex mixtures is very much essential. In the present study, a sensitive methodology for optimal visualization of unstained or untagged proteins in native poly-acrylamide gel electrophoresis (N-PAGE) has been developed where, concentration of the acrylamide and bis-acrylamide mixture, Percentage of the gel, fixing of the N-PAGE by methanol: acetic acid: water and washing of the gel in the mili-Q water has been optimized for highest sensitivity using laser induced autofluorescence. The outcome with bovine serum albumin (BSA) in PAGE was found to be highest at acrylamide and bis-acrylamide concentrations of 29.2 and 0.8 respectively in 12% N-PAGE. After the electrophoresis run, washing of the N-PAGE immediately with miliQ water for 12 times and eliminating the methanol: acetic acid: water, fixing of the N-PAGE yielded better sensitivity of visualization. Using the above methodology 25ng of BSA protein band in PAGE was clearly identified by the technique. The currently used staining techniques for the visualization of proteins are coomassie brilliant blue and silver staining, have the sensitivity of 100ng and 5ng respectively. The current methodology was found to be more sensitive as compared to coomassie staining and less sensitive compared to silver staining respectively. The added advantage of this methodology is the faster visualization of proteins without altering their structure and functional properties.

  18. Mutations in LRP5 cause primary osteoporosis without features of OI by reducing Wnt signaling activity

    PubMed Central

    2012-01-01

    Background Primary osteoporosis is a rare childhood-onset skeletal condition whose pathogenesis has been largely unknown. We have previously shown that primary osteoporosis can be caused by heterozygous missense mutations in the Low-density lipoprotein receptor-related protein 5 (LRP5) gene, and the role of LRP5 is further investigated here. Methods LRP5 was analyzed in 18 otherwise healthy children and adolescents who had evidence of osteoporosis (manifested as reduced bone mineral density i.e. BMD, recurrent peripheral fractures and/or vertebral compression fractures) but who lacked the clinical features of osteogenesis imperfecta (OI) or other known syndromes linked to low BMD. Also 51 controls were analyzed. Methods used in the genetic analyses included direct sequencing and multiplex ligation-dependent probe amplification (MLPA). In vitro studies were performed using luciferase assay and quantitative real-time polymerase chain reaction (qPCR) to examine the effect of two novel and three previously identified mutations on the activity of canonical Wnt signaling and on expression of tryptophan hydroxylase 1 (Tph1) and 5-hydroxytryptamine (5-Htr1b). Results Two novel LRP5 mutations (c.3446 T > A; p.L1149Q and c.3553 G > A; p.G1185R) were identified in two patients and their affected family members. In vitro analyses showed that one of these novel mutations together with two previously reported mutations (p.C913fs, p.R1036Q) significantly reduced the activity of the canonical Wnt signaling pathway. Such reductions may lead to decreased bone formation, and could explain the bone phenotype. Gut-derived Lrp5 has been shown to regulate serotonin synthesis by controlling the production of serotonin rate-limiting enzyme, Tph1. LRP5 mutations did not affect Tph1 expression, and only one mutant (p.L1149Q) reduced expression of serotonin receptor 5-Htr1b (p < 0.002). Conclusions Our results provide additional information on the role of LRP5 mutations and their effects on

  19. Features of the planetary distribution of ion precipitation at different levels of magnetic activity

    NASA Astrophysics Data System (ADS)

    Vorobjev, V. G.; Yagodkina, O. I.; Antonova, E. E.

    2015-09-01

    Observations from DMSP F6 and F7 spacecraft were used to examine the features of the planetary distribution of ion precipitation. Ion characteristics were defined within the boundaries of different types of auroral electron precipitation, which in accordance with the conclusions from (Starkov et al., 2002) were divided into a structured precipitation of an auroral oval (AOP) and zones of diffuse precipitation DAZ and SDP located equatorward and poleward of AOP, respectively. Analogous to electron precipitation, ion precipitation did not demonstrate dependences of the average energy and the average energy flux of precipitating particles on the Dst index value. In the diffuse precipitation zone (DAZ) equatorward of the auroral oval, ion energies clearly peaked in the sector of 1500-1800 MLT. The average energy value grows as magnetic activity increases from ~12 keV at AL =-1000 nT to ~18 keV at AL =-1000 nT. In the region of structured precipitation (AOP), the minimum of the average ion energy is observed in the dawn sector of 0600-0900 MLT. Ion energy fluxes ( F i ) are maximal in the nighttime MLT sectors. In the zone of soft diffuse precipitation (SDP) poleward of AOP, the highest ion energy fluxes are observed in the daytime sector, while the nightside F i values are insignificant. Ion energy fluxes in the SDP zone show an anticorrelation with the average ion energy in the same MLT sector. An ion precipitation model was created which yields a global distribution of both the average ion energies and the ion energy fluxes depending on the magnetic activity expressed by AL and Dst indices. Comparison of this model with the model of electron precipitation shows that the planetary power of ion precipitation at low magnetic activity (| AL| = 100 nT) is ~12% of the electron precipitation power and exponentially decreases to ~4% at | AL| > 1000 nT. The ion precipitation model was used to calculate the plasma pressure at the ionospheric altitudes. The planetary

  20. Common features and peculiarities of the seismic activity at Phlegraean Fields, Long Valley, and Vesuvius

    USGS Publications Warehouse

    Marzocchi, W.; Vilardo, G.; Hill, D.P.; Ricciardi, G.P.; Ricco, C.

    2001-01-01

    We analyzed and compared the seismic activity that has occurred in the last two to three decades in three distinct volcanic areas: Phlegraean Fields, Italy; Vesuvius, Italy; and Long Valley, California. Our main goal is to identify and discuss common features and peculiarities in the temporal evolution of earthquake sequences that may reflect similarities and differences in the generating processes between these volcanic systems. In particular, we tried to characterize the time series of the number of events and of the seismic energy release in terms of stochastic, deterministic, and chaotic components. The time sequences from each area consist of thousands of earthquakes that allow a detailed quantitative analysis and comparison. The results obtained showed no evidence for either deterministic or chaotic components in the earthquake sequences in Long Valley caldera, which appears to be dominated by stochastic behavior. In contrast, earthquake sequences at Phlegrean Fields and Mount Vesuvius show a deterministic signal mainly consisting of a 24-hour periodicity. Our analysis suggests that the modulation in seismicity is in some way related to thermal diurnal processes, rather than luni-solar tidal effects. Independently from the process that generates these periodicities on the seismicity., it is suggested that the lack (or presence) of diurnal cycles is seismic swarms of volcanic areas could be closely linked to the presence (or lack) of magma motion.

  1. Automatic Hidden-Web Table Interpretation by Sibling Page Comparison

    NASA Astrophysics Data System (ADS)

    Tao, Cui; Embley, David W.

    The longstanding problem of automatic table interpretation still illudes us. Its solution would not only be an aid to table processing applications such as large volume table conversion, but would also be an aid in solving related problems such as information extraction and semi-structured data management. In this paper, we offer a conceptual modeling solution for the common special case in which so-called sibling pages are available. The sibling pages we consider are pages on the hidden web, commonly generated from underlying databases. We compare them to identify and connect nonvarying components (category labels) and varying components (data values). We tested our solution using more than 2,000 tables in source pages from three different domains—car advertisements, molecular biology, and geopolitical information. Experimental results show that the system can successfully identify sibling tables, generate structure patterns, interpret tables using the generated patterns, and automatically adjust the structure patterns, if necessary, as it processes a sequence of hidden-web pages. For these activities, the system was able to achieve an overall F-measure of 94.5%.

  2. Utility of passive photography to objectively audit built environment features of active transport journeys: an observational study

    PubMed Central

    2013-01-01

    Background Active transport can contribute to physical activity accumulation and improved health in adults. The built environment is an established associate of active transport behaviours; however, assessment of environmental features encountered during journeys remains challenging. The purpose of this study was to examine the utility of wearable cameras to objectively audit and quantify environmental features along work-related walking and cycling routes. Methods A convenience sample of employed adults was recruited in New Zealand, in June 2011. Participants wore a SenseCam for all journeys over three weekdays and completed travel diaries and demographic questionnaires. SenseCam images for work-related active transport journeys were coded for presence of environmental features hypothesised to be related to active transport. Differences in presence of features by transport mode and in participant-reported and SenseCam-derived journey duration were determined using two-sample tests of proportion and an independent samples t-test, respectively. Results Fifteen adults participated in the study, yielding 1749 SenseCam images from 30 work-related active transport journeys for coding. Significant differences in presence of features were found between walking and cycling journeys. Almost a quarter of images were uncodeable due to being too dark to determine features. There was a non-significant tendency for respondents to under-report their journey duration. Conclusion This study provides proof of concept for the use of the SenseCam to capture built environment data in real time that may be related to active transportation. Further work is required to test and refine coding methodologies across a range of settings, travel behaviours, and demographic groups. PMID:23575288

  3. Feature Statistics Modulate the Activation of Meaning during Spoken Word Processing

    ERIC Educational Resources Information Center

    Devereux, Barry J.; Taylor, Kirsten I.; Randall, Billi; Geertzen, Jeroen; Tyler, Lorraine K.

    2016-01-01

    Understanding spoken words involves a rapid mapping from speech to conceptual representations. One distributed feature-based conceptual account assumes that the statistical characteristics of concepts' features--the number of concepts they occur in ("distinctiveness/sharedness") and likelihood of co-occurrence ("correlational…

  4. Creating a Facebook Page for the Seismological Society of America

    NASA Astrophysics Data System (ADS)

    Newman, S. B.

    2009-12-01

    In August, 2009 I created a Facebook “fan” page for the Seismological Society of America. We had been exploring cost-effective options for providing forums for two-way communication for some months. We knew that a number of larger technical societies had invested significant sums of money to create customized social networking sites but that a small society would need to use existing low-cost software options. The first thing I discovered when I began to set up the fan page was that an unofficial SSA Facebook group already existed, established by Steven J. Gibbons, a member in Norway. Steven had done an excellent job of posting material about SSA. Partly because of the existing group, the official SSA fan page gained fans rapidly. We began by posting information about our own activities and then added links to activities in the broader geoscience community. While much of this material also appeared on our website and in our publication, Seismological Research Letters (SRL), the tone on the FB page is different. It is less formal with more emphasis on photos and links to other sites, including our own. Fans who are active on FB see the posts as part of their social network and do not need to take the initiative to go to the SSA site. Although the goal was to provide a forum for two-way communication, our initial experience was that people were clearly reading the page but not contributing content. This appears to be case with fan pages of sister geoscience societies. FB offers some demographic information to fan site administrators. In an initial review of the demographics it appeared that fans were younger than the overall demographics of the Society. It appeared that a few of the fans are not members or even scientists. Open questions are: what content will be most useful to fans? How will the existence of the page benefit the membership as a whole? Will the page ultimately encourage two-way communication as hoped? Web 2.0 is generating a series of new

  5. Teacher Web Pages that Build Parent Partnerships.

    ERIC Educational Resources Information Center

    Johnson, Doug

    2000-01-01

    Discusses the importance of collaboration between teachers and parents to help support students and describes teacher-created Web pages that help simplify communication and planning. Explains Web page design that can include general class descriptions, unit outlines and timetables, unit and project information, and student progress reports. (LRW)

  6. Automated Title Page Cataloging: A Feasibility Study.

    ERIC Educational Resources Information Center

    Weibel, Stuart; And Others

    1989-01-01

    Describes the design of a prototype rule-based system for the automation of descriptive cataloging from title pages. The discussion covers the results of tests of the prototype, major impediments to automatic cataloging from title pages, and prospects for further progress. The rules implemented in the prototype are appended. (16 references)…

  7. Adding Sound and Video to Web Pages.

    ERIC Educational Resources Information Center

    Duval, Beverly K.; Main, Linda

    1997-01-01

    Explains how to incorporate sound and video into Web pages with special software and HTML tags. Topics include creating sound files; sound formats; video technology; video formats; referencing sound and video files in HTML pages; embedding sounds and videos; players, plug-ins, and viewers; sound and video files from the Web; and streaming. (LRW)

  8. Preventing radio-paging system tieup

    NASA Technical Reports Server (NTRS)

    Jasmin, J. P.

    1978-01-01

    Time-delay relay limits message time of emergency radio-paging system, thereby preventing inadvertent tieup. Relay is connected with telephone circuit and permits adjustable message time between 30 and 55 seconds. After that time interval, relay opens, making line free for another paging regardless of what previous caller did with his telephone.

  9. 40 CFR 1502.7 - Page limits.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Page limits. 1502.7 Section 1502.7 Protection of Environment COUNCIL ON ENVIRONMENTAL QUALITY ENVIRONMENTAL IMPACT STATEMENT § 1502.7 Page limits. The text of final environmental impact statements (e.g., paragraphs (d) through (g) of §...

  10. An introduction to Turning the Pages.

    PubMed

    Kinally, Bridget; Stocking, Michael

    2007-06-01

    Turning the Pages, the award-winning interactive program developed by the British Library, provides access to unique medical resources held by the Wellcome Library, allowing visitors to 'turn' the pages virtually, zoom in on the high-quality digitized images and read (or listen to) notes explaining the beauty and significance of each text. PMID:17671916

  11. Minimal Guidelines for Authors of Web Pages.

    ERIC Educational Resources Information Center

    ADE Bulletin, 2002

    2002-01-01

    Presents guidelines that recommend the minimal reference information that should be provided on Web pages intended for use by students, teachers, and scholars in the modern languages. Suggests the inclusion of information about responsible parties, copyright declaration, privacy statements, and site information. Makes a note on Web page style. (SG)

  12. 40 CFR 1502.7 - Page limits.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 34 2012-07-01 2012-07-01 false Page limits. 1502.7 Section 1502.7 Protection of Environment COUNCIL ON ENVIRONMENTAL QUALITY ENVIRONMENTAL IMPACT STATEMENT § 1502.7 Page limits. The text of final environmental impact statements (e.g., paragraphs (d) through (g) of §...

  13. Autobiographical Planning and the Brain: Activation and Its Modulation by Qualitative Features.

    PubMed

    Spreng, R Nathan; Gerlach, Kathy D; Turner, Gary R; Schacter, Daniel L

    2015-11-01

    To engage in purposeful behavior, it is important to make plans, which organize subsequent actions. Most studies of planning involve "look-ahead" puzzle tasks that are unrelated to personal goals. We developed a task to assess autobiographical planning, which involves the formulation of personal plans in response to real-world goals, and examined autobiographical planning in 63 adults during fMRI scanning. Autobiographical planning was found to engage the default network, including medial-temporal lobe and midline structures, and executive control regions in lateral pFC and parietal cortex and caudate. To examine how specific qualitative features of autobiographical plans modulate neural activity, we performed parametric modulation analyses. Ratings of plan detail, novelty, temporal distance, ease of plan formulation, difficulty in goal completion, and confidence in goal accomplishment were used as covariates in six hierarchical linear regression models. This modeling procedure removed shared variance among the ratings, allowing us to determine the independent relationship between ratings of interest and trial-wise BOLD signal. We found that specific autobiographical planning, describing a detailed, achievable, and actionable planning process for attaining a clearly envisioned future, recruited both default and frontoparietal brain regions. In contrast, abstract autobiographical planning, plans that were constructed from more generalized semantic or affective representations of a less tangible and distant future, involved interactions among default, sensory perceptual, and limbic brain structures. Specific qualities of autobiographical plans are important predictors of default and frontoparietal control network engagement during plan formation and reflect the contribution of mnemonic and executive control processes to autobiographical planning. PMID:26102226

  14. Monoaminergic tone supports conductance correlations and stabilizes activity features in pattern generating neurons of the lobster, Panulirus interruptus.

    PubMed

    Krenz, Wulf-Dieter; Parker, Anna R; Rodgers, Edmund; Baro, Deborah J

    2015-01-01

    Experimental and computational studies demonstrate that different sets of intrinsic and synaptic conductances can give rise to equivalent activity patterns. This is because the balance of conductances, not their absolute values, defines a given activity feature. Activity-dependent feedback mechanisms maintain neuronal conductance correlations and their corresponding activity features. This study demonstrates that tonic nM concentrations of monoamines enable slow, activity-dependent processes that can maintain a correlation between the transient potassium current (I(A) and the hyperpolarization activated current (Ih) over the long-term (i.e., regulatory change persists for hours after removal of modulator). Tonic 5 nM DA acted through an RNA interference silencing complex (RISC)- and RNA polymerase II-dependent mechanism to maintain a long-term positive correlation between I(A) and Ih in the lateral pyloric neuron (LP) but not in the pyloric dilator neuron (PD). In contrast, tonic 5 nM 5HT maintained a RISC-dependent positive correlation between I(A) and Ih in PD but not LP over the long-term. Tonic 5 nM OCT maintained a long-term negative correlation between I(A) and Ih in PD but not LP; however, it was only revealed when RISC was inhibited. This study also demonstrated that monoaminergic tone can also preserve activity features over the long-term: the timing of LP activity, LP duty cycle and LP spike number per burst were maintained by tonic 5 nM DA. The data suggest that low-level monoaminergic tone acts through multiple slow processes to permit cell-specific, activity-dependent regulation of ionic conductances to maintain conductance correlations and their corresponding activity features over the long-term. PMID:26539083

  15. Monoaminergic tone supports conductance correlations and stabilizes activity features in pattern generating neurons of the lobster, Panulirus interruptus

    PubMed Central

    Krenz, Wulf-Dieter; Parker, Anna R.; Rodgers, Edmund; Baro, Deborah J.

    2015-01-01

    Experimental and computational studies demonstrate that different sets of intrinsic and synaptic conductances can give rise to equivalent activity patterns. This is because the balance of conductances, not their absolute values, defines a given activity feature. Activity-dependent feedback mechanisms maintain neuronal conductance correlations and their corresponding activity features. This study demonstrates that tonic nM concentrations of monoamines enable slow, activity-dependent processes that can maintain a correlation between the transient potassium current (IA) and the hyperpolarization activated current (Ih) over the long-term (i.e., regulatory change persists for hours after removal of modulator). Tonic 5 nM DA acted through an RNA interference silencing complex (RISC)- and RNA polymerase II-dependent mechanism to maintain a long-term positive correlation between IA and Ih in the lateral pyloric neuron (LP) but not in the pyloric dilator neuron (PD). In contrast, tonic 5 nM 5HT maintained a RISC-dependent positive correlation between IA and Ih in PD but not LP over the long-term. Tonic 5 nM OCT maintained a long-term negative correlation between IA and Ih in PD but not LP; however, it was only revealed when RISC was inhibited. This study also demonstrated that monoaminergic tone can also preserve activity features over the long-term: the timing of LP activity, LP duty cycle and LP spike number per burst were maintained by tonic 5 nM DA. The data suggest that low-level monoaminergic tone acts through multiple slow processes to permit cell-specific, activity-dependent regulation of ionic conductances to maintain conductance correlations and their corresponding activity features over the long-term. PMID:26539083

  16. Some features of the bioelectric activity of the muscles with prolonged hypokinesia

    NASA Technical Reports Server (NTRS)

    Belaya, N. A.; Amirov, R. Z.; Shaposhnikov, Y. A.; Lebedeva, I. P.; Sologub, B. S.

    1978-01-01

    The effects of prolonged hypokinesia, brought on by confinement to bed and the attendant lack of motor activity, on the bioelectric activity of muscles are studied. Electromyographic measurements of amplitude and frequency indicators of muscular bioelectric activity were analyzed.

  17. Building Model NASA Satellites: Elementary Students Studying Science Using a NASA-Themed Transmedia Book Featuring Digital Fabrication Activities

    ERIC Educational Resources Information Center

    Tillman, Daniel; An, Song; Boren, Rachel; Slykhuis, David

    2014-01-01

    This study assessed the impact of nine lessons incorporating a NASA-themed transmedia book featuring digital fabrication activities on 5th-grade students (n = 29) recognized as advanced in mathematics based on their academic record. Data collected included a pretest and posttest of science content questions taken from released Virginia Standards…

  18. 47 CFR 79.110 - Complaint procedures for user interfaces, menus and guides, and activating accessibility features...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 4 2014-10-01 2014-10-01 false Complaint procedures for user interfaces, menus and guides, and activating accessibility features on digital apparatus and navigation devices. 79.110... ACCESSIBILITY OF VIDEO PROGRAMMING Apparatus § 79.110 Complaint procedures for user interfaces, menus and...

  19. Object detection and tracking with active camera on motion vectors of feature points and particle filter.

    PubMed

    Chen, Yong; Zhang, Rong-Hua; Shang, Lei; Hu, Eric

    2013-06-01

    A method based on motion vectors of feature points and particle filter has been proposed and developed for an active∕moving camera for object detection and tracking purposes. The object is detected by histogram of motion vectors first, and then, on the basis of particle filter algorithm, the weighing factors are obtained via color information. In addition, re-sampling strategy and surf feature points are used to remedy the drawback of particle degeneration. Experimental results demonstrate the practicability and accuracy of the new method and are presented in the paper. PMID:23822380

  20. Activity Participation and Sensory Features among Children with Autism Spectrum Disorders

    ERIC Educational Resources Information Center

    Little, Lauren M.; Ausderau, Karla; Sideris, John; Baranek, Grace T.

    2015-01-01

    Sensory features are highly prevalent among children with autism spectrum disorders (ASD) and have been shown to cluster into four patterns of response, including hyperresponsiveness, hyporesponsiveness, enhanced perception, and sensory interests, repetitions and seeking behaviors. Given the lack of large-scale research on the differential effects…

  1. Interfacial Reaction-Driven Formation of Silica Carbonate Biomorphs with Subcellular Topographical Features and Their Biological Activity.

    PubMed

    Wang, Guocheng; Zhao, Xiaobing; Möller, Marco; Moya, Sergio E

    2015-10-28

    We report the interfacial reaction-driven formation of micro/nanostructured strontium carbonate (SrCO3) biomorphs with subcellular topographical features on strontium zinc silicate (Sr2ZnSi2O7) biomedical coatings and explore their potential use in bone tissue engineering. The resulting SrCO3 crystals build a well-integrated scaffold surface that not only prevents burst release of ions from the coating but also presents nanotopographical features similar to cellular filopodia. The surface with biomorphic crystals enhances osteoblast adhesion, upregulates the alkaline phosphatase activity, and increases collagen production, highlighting the potential of the silica carbonate biomorphs for tissue regeneration. PMID:26455427

  2. Features and amenities of school playgrounds: A direct observation study of utilization and physical activity levels outside of school time

    PubMed Central

    2011-01-01

    Background A significant amount of research has examined whether park or playground availability is associated with physical activity. However, little research has examined whether specific features or amenities of parks or playgrounds, such as the number of unique types of playground equipment or the safety of the equipment is associated with utilization of the facility or physical activity levels while at the facility. There are no studies that use direct observation and a detailed park assessment to examine these associations. Methods Twenty urban schoolyards in the Midwest, ten of which were renovated, were included in this study. Using a detailed environmental assessment tool (i.e., Environmental Assessment of Public Recreation Spaces), information on a variety of playground attributes was collected. Using direct observation (i.e., System for Observing Play and Leisure Activity in Youth), the number of adults, girls and boys attending each schoolyard and their physical activity levels were recorded. Each schoolyard was observed ten times for 90 minutes each time outside of school hours. Clustered multivariable negative binomial regressions and linear regressions were completed to examine the association between playground attributes and utilization of the schoolyard and the proportion active on the playground, respectively. Effect modification by renovation status was also examined. Results At renovated schoolyards, the total number of play features was significantly associated with greater utilization in adults and girls; overall cleanliness was significantly associated with less utilization in girls and boys; and coverage/shade for resting features was significantly associated with greater utilization in adults and boys. At unrenovated schoolyards, overall safety was significantly associated with greater utilization in boys. No playground attribute was associated with the proportion active on the playground after adjusting for all other significant

  3. New Cloud Activity on Uranus in 2004: First Detection of a Southern Feature at 2.2 microns

    NASA Astrophysics Data System (ADS)

    Hammel, H. B.; de Pater, I.; Gibbard, S. G.; Lockwood, G. W.; Rages, K.

    2004-11-01

    On 4 July 2004 UT, we detected a southern hemispheric cloud feature on Uranus at K' (2.2 microns) using adaptive optics and the NIRC2 camera on the Keck 10-m. At H (1.6 microns), the feature had two components: a condensed core (2004-A) co-located with the K' feature at latitude -36.0 ± 0.4 deg, and an extended feature (2004-B) at roughly -33.7 ± 0.4 deg. When we observed again on 8 July UT, the core had faded at K'. By 9 July we were unable to detect a K' feature; the extended feature was still seen at H. The initial high K'-brightness of 2004-A indicates that the core's scattering particles reached altitudes above the 1-bar level, with the larger feature at H, 2004-B, residing below the 1.1-bar level (assuming the model of de Pater et al. 2002, Icarus 160, 359). The core's rapid disappearance at K' indicates dynamical processes in the local vertical aerosol structure, for example, subsidence of the feature's cloud tops. Features 2004-A and 2004-B had zonal velocities of 107 and 115 m/s, respectively (+/- 3 m/s), different from past velocities near these latitudes. These features are either new, or are long-lived but drifting in latitude (as has been seen on Neptune); see abstract by Rages et al. this volume. Regardless of their latitude, no southern features on Uranus have been detected at wavelengths of 2 microns or longward, indicating some change of activity. Continued observations of Uranus are strongly encouraged as its 2007 equinox approaches. HBH acknowledges partial support from NASA grants NAG5-11961 and NAG5-10451. IdP acknowledges partial support from NSF and the Technology Center for Adaptive Optics, managed by UCSC under cooperative agreement No. AST-9876783. SGG's work was performed under the auspices of the U.S. DoE, National Nuclear Security Administration by the UC, LLNL under contract No. W-7405-Eng-48.

  4. Description Meta Tags in Public Home and Linked Pages.

    ERIC Educational Resources Information Center

    Craven, Timothy C.

    2001-01-01

    Random samples of 1,872 Web pages registered with Yahoo! And 1,638 pages reachable from Yahoo!-registered pages were analyzed for use of meta tags and specifically those containing descriptions. Results: 727 (38.8%) of the Yahoo!-registered pages and 442 (27%) of the other pages included descriptions in meta tages. Some descriptions greatly…

  5. AGU acts on NSF Page Charge Policy

    NASA Astrophysics Data System (ADS)

    Fast action by Headquarters alerted AGU members to a proposed change to the National Science Foundation's page charge policy that would weaken the ability of scientific societies to serve the scientific community.If adopted, NSF's new policy, announced in the Federal Register December 18, would remove the prohibition against allowing page charges to commercially produced journals. The proposal for the change was supposedly put forth to obtain a reaction from the scientific community.

  6. Feature-specific imaging: Extensions to adaptive object recognition and active illumination based scene reconstruction

    NASA Astrophysics Data System (ADS)

    Baheti, Pawan K.

    Computational imaging (CI) systems are hybrid imagers in which the optical and post-processing sub-systems are jointly optimized to maximize the task-specific performance. In this dissertation we consider a form of CI system that measures the linear projections (i.e., features) of the scene optically, and it is commonly referred to as feature-specific imaging (FSI). Most of the previous work on FSI has been concerned with image reconstruction. Previous FSI techniques have also been non-adaptive and restricted to the use of ambient illumination. We consider two novel extensions of the FSI system in this work. We first present an adaptive feature-specific imaging (AFSI) system and consider its application to a face-recognition task. The proposed system makes use of previous measurements to adapt the projection basis at each step. We present both statistical and information-theoretic adaptation mechanisms for the AFSI system. The sequential hypothesis testing framework is used to determine the number of measurements required for achieving a specified misclassification probability. We demonstrate that AFSI system requires significantly fewer measurements than static-FSI (SFSI) and conventional imaging at low signal-to-noise ratio (SNR). We also show a trade-off, in terms of average detection time, between measurement SNR and adaptation advantage. Experimental results validating the AFSI system are presented. Next we present a FSI system based on the use of structured light. Feature measurements are obtained by projecting spatially structured illumination onto an object and collecting all of the reflected light onto a single photodetector. We refer to this system as feature-specific structured imaging (FSSI). Principal component features are used to define the illumination patterns. The optimal LMMSE operator is used to generate object estimates from the measurements. We demonstrate that this new imaging approach reduces imager complexity and provides improved image

  7. A Web Page Summarization for Mobile Phones

    NASA Astrophysics Data System (ADS)

    Hasegawa, Takaaki; Nishikawa, Hitoshi; Imamura, Kenji; Kikui, Gen'ichiro; Okumur, Manabu

    Recently, web pages for mobile devices are widely spread on the Internet and a lot of people can access web pages through search engines by mobile devices as well as personal computers. A summary of a retrieved web page is important because the people judge whether or not the page would be relevant to their information need according to the summary. In particular, the summary must be not only compact but also grammatical and meaningful when the users retrieve information using a mobile phone with a small screen. Most search engines seem to produce a snippet based on the keyword-in-context (KWIC) method. However, this simple method could not generate a refined summary suitable for mobile phones because of low grammaticality and content overlap with the page title. We propose a more suitable method to generate a snippet for mobile devices using sentence extraction and sentence compression methods. First, sentences are biased based on whether they include the query terms from the users or words that are relevant to the queries, as well as whether they do not overlap with the page title based on maximal marginal relevance (MMR). Second, the selected sentences are compressed based on their phrase coverage, which is measured by the scores of words, and their phrase connection probability measured based on the language model, according to the dependency structure converted from the sentence. The experimental results reveal the proposed method outperformed the KWIC method in terms of relevance judgment, grammaticality, non-redundancy and content coverage.

  8. Antiprotozoal activity of bicycles featuring a dimethylamino group at their bridgehead.

    PubMed

    Faist, Johanna; Seebacher, Werner; Saf, Robert; Brun, Reto; Kaiser, Marcel; Weis, Robert

    2016-08-15

    Several dimethylamino-derivatives of the new compound-class 3-azabicyclo[3.2.2]nonanes were prepared. For better comparison of activity also a few analogues of bicyclo[2.2.2]octanes and 2-azabicyclo[3.2.2]nonanes were synthesized. Their activities were examined in vitro against the multiresistant K1 strain of Plasmodium falciparum and against Trypanosoma brucei rhodesiense (STIB 900). A couple of the newly synthesized compounds showed promising antiprotozoal activity and selectivity. The results of the biological tests of the novel compounds were compared with the activities of already synthesized compounds and of drugs in use. Structure-activity relationships were discussed. PMID:27344215

  9. A novel sodium bis(2-ethylhexyl) sulfosuccinate-PAGE system suitable for the separation of small peptides.

    PubMed

    Lu, Xuemei; Yao, Yao; Zhang, Weican

    2007-09-01

    A novel sodium bis(2-ethylhexyl) sulfosuccinate-PAGE (AOT-PAGE) system which delivers high resolution and sensitivity for small peptides with molecular masses of 0.8-17 kDa is described. Small peptides migrate more slowly and are less prone to leakage than in conventional SDS-PAGE, thus allowing for the in-gel detection with CBB R 250 of 0.5 mug of peptide. The system is also compatible with electroblotting, activity staining in renatured gels, and the peptide analysis by MALDI-MS. AOT-PAGE is simpler, more rapid, and cheaper than the generally adopted Tricine-SDS-PAGE method. PMID:17854120

  10. Polarization features of solar radio emission and possible existence of current sheets in active regions

    NASA Technical Reports Server (NTRS)

    Gopalswamy, N.; Zheleznyakov, V. V.; White, S. M.; Kundu, M. R.

    1994-01-01

    We show that it is possible to account for the polarization features of solar radio emission provided the linear mode coupling theory is properly applied and the presence of current sheets in the corona is taken into account. We present a schematic model, including a current sheet that can explain the polarization features of both the low frequency slowly varying component and the bipolar noise storm radiation; the two radiations face similar propagation conditions through a current sheet and hence display similar polarization behavior. We discuss the applications of the linear mode coupling theory to the following types of solar emission: the slowly varying component, the microwave radio bursts, metric type U bursts, and bipolar noise storms.

  11. JCE Feature Columns

    NASA Astrophysics Data System (ADS)

    Holmes, Jon L.

    1999-05-01

    The Features area of JCE Online is now readily accessible through a single click from our home page. In the Features area each column is linked to its own home page. These column home pages also have links to them from the online Journal Table of Contents pages or from any article published as part of that feature column. Using these links you can easily find abstracts of additional articles that are related by topic. Of course, JCE Online+ subscribers are then just one click away from the entire article. Finding related articles is easy because each feature column "site" contains links to the online abstracts of all the articles that have appeared in the column. In addition, you can find the mission statement for the column and the email link to the column editor that I mentioned above. At the discretion of its editor, a feature column site may contain additional resources. As an example, the Chemical Information Instructor column edited by Arleen Somerville will have a periodically updated bibliography of resources for teaching and using chemical information. Due to the increase in the number of these resources available on the WWW, it only makes sense to publish this information online so that you can get to these resources with a simple click of the mouse. We expect that there will soon be additional information and resources at several other feature column sites. Following in the footsteps of the Chemical Information Instructor, up-to-date bibliographies and links to related online resources can be made available. We hope to extend the online component of our feature columns with moderated online discussion forums. If you have a suggestion for an online resource you would like to see included, let the feature editor or JCE Online (jceonline@chem.wisc.edu) know about it. JCE Internet Features JCE Internet also has several feature columns: Chemical Education Resource Shelf, Conceptual Questions and Challenge Problems, Equipment Buyers Guide, Hal's Picks, Mathcad

  12. Can simple interactions capture complex features of neural activity underlying behavior in a virtual reality environment?

    NASA Astrophysics Data System (ADS)

    Meshulam, Leenoy; Gauthier, Jeffrey; Brody, Carlos; Tank, David; Bialek, William

    The complex neural interactions which are abundant in most recordings of neural activity are relatively poorly understood. A prime example of such interactions can be found in the in vivo neural activity which underlies complex behaviors of mice, imaged in brain regions such as hippocampus and parietal cortex. Experimental techniques now allow us to accurately follow these neural interactions in the simultaneous activity of large neuronal populations of awake behaving animals. Here, we demonstrate that pairwise maximum entropy models can predict a surprising number of properties of the neural activity. The models, that are constrained with activity rates and interactions between pairs of neurons, are well fit to the activity `states' in the hippocampus and cortex of mice performing cognitive tasks while navigating in a virtual reality environment.

  13. On the importance of anandamide structural features for its interactions with DPPC bilayers: effects on PLA2 activity.

    PubMed

    Ambrosi, S; Ragni, L; Ambrosini, A; Paccamiccio, L; Mariani, P; Fiorini, R; Bertoli, E; Zolese, G

    2005-09-01

    The acylethanolamide anandamide (AEA) occurs in a variety of mammalian tissues and, as a result of its action on cannabinoid receptors, exhibits several cannabimimetic activities. Moreover, some of its effects are mediated through interaction with an ion channel-type vanilloid receptor. However, the chemical features of AEA suggest that some of its biological effects could be related to physical interactions with the lipidic part of the membrane. The present work studies the effect of AEA-induced structural modifications of the dipalmitoylphosphatidylcholine (DPPC) bilayer on phospholipase A2 (PLA2) activity, which is strictly dependent on lipid bilayer features. This study, performed by 2-dimethylamino-(6-lauroyl)-naphthalene fluorescence, demonstrates that the effect of AEA on PLA2 activity is concentration-dependent. In fact, at low AEA/DPPC molar ratios (from R = 0.001 to R = 0.04), there is an increase of the enzymatic activity, which is completely inhibited for R = 0.1. X-ray diffraction data indicate that the AEA affects DPPC membrane structural properties in a concentration-dependent manner. Because the biphasic effect of increasing AEA concentrations on PLA2 activity is related to the induced modifications of membrane bilayer structural properties, we suggest that AEA-phospholipid interactions may be important to produce, at least in part, some of the similarly biphasic responses of some physiological activities to increasing concentrations of AEA. PMID:15961786

  14. Common Features of Professional Development Activities for Mathematics and Science Teachers

    ERIC Educational Resources Information Center

    Moyer-Packenham, Patricia S.; Bolyard, Johnna J.; Oh, Hana; Cerar, Nancy Irby

    2011-01-01

    This study examines professional development activities provided for mathematics and science teachers in the National Science Foundation's Math and Science Partnership Program by analyzing a cross-sectional sample of over 2000 professional development (PD) activities in the program. Data were gathered from secondary source documents and surveys to…

  15. The Luminous Polycyclic Aromatic Hydrocarbon Emission Features: Applications to High Redshift Galaxies and Active Galactic Nuclei

    NASA Astrophysics Data System (ADS)

    Shipley, Heath V.

    2016-01-01

    For decades, significant work has been applied to calibrating emission from the ultra-violet, nebular emission lines, far-infrared, X-ray and radio as tracers of the star-formation rate (SFR) in distant galaxies. Understanding the exact rate of star-formation and how it evolves with time and galaxy mass has deep implications for how galaxies form. The co-evolution of star-formation and supermassive black hole (SMBH) accretion is one of the key problems in galaxy formation theory. But, many of these SFR indicators are influenced by SMBH accretion in galaxies and result in unreliable SFRs. Utilizing the luminous polycyclic aromatic hydrocarbon (PAH) emission features, I provide a new robust SFR calibration using the luminosity emitted from the PAHs at 6.2μm, 7.7μm and 11.3μm to solve this. The PAH features emit strongly in the mid-infrared (mid-IR; 5-25μm) mitigating dust extinction, containing on average 5-10% of the total IR luminosity in galaxies. I use a sample of 105 star-forming galaxies covering a range of total IR luminosity, LIR = L(8-1000μm) = 109 - 1012 L⊙ and redshift 0 < z < 0.4, with mid-IR spectroscopy from the Spitzer Infrared Spectrograph (IRS), and data covering other SFR indicators (Hα emission and rest-frame 24μm continuum emission). The PAH luminosity correlates linearly with the SFR as measured by the Hα luminosity (corrected for attenuation using the mono-chromatic rest-frame 24μm emission), with a tight scatter of <0.15 dex. The scatter is comparable to that between SFRs derived from the Paα and dust-corrected Hα emission lines. We present a case study in advance of JWST, which will be capable of measuring SFRs (from 8μm rest-frame photometry, i.e. PAHs) in distant galaxies (z ≤ 2) with JWST/MIRI to SFRs as low as ~10 M⊙yr-1, because the PAH features are so bright. We use Spitzer/IRS observations of PAH features in lensed star-forming galaxies at 1 < z < 3 to demonstrate the utility of the PAHs to derive SFRs that agree with

  16. Features of the Built Environment Related to Physical Activity Friendliness and Children’s Obesity and Other Risk Factors

    PubMed Central

    Taylor, Wendell C.; Upchurch, Sandra L.; Brosnan, Christine A.; Selwyn, Beatrice J.; Nguyen, Thong Q.; Villagomez, Evangelina Trejo; Meininger, Janet C.

    2014-01-01

    Objectives We investigated the relationships among environmental features of physical activity friendliness, socioeconomic indicators, and prevalence of obesity (BMI status), central adiposity (waist circumference, waist-height ratio), and hypertension. Design The design was cross-sectional; the study was correlational. Sample The sample was 911 kindergarteners through sixth graders from three schools in an urban school district residing in 13 designated neighborhoods. Measurements Data from walking environmental community audits, census data for socioeconomic indicators, body mass index, waist circumference, waist-height ratio, and blood pressure were analyzed. A modified Alfonzo’s Hierarchy of Walking Needs model was the conceptual framework for environmental features (i.e., accessibility, safety, comfort, and pleasurability) related to physical activity. Results Accessibility was significantly and negatively correlated with prevalence of obesity and with prevalence of a waist-height ratio > 0.50. When neighborhood education was controlled, and when both neighborhood education and poverty were controlled with partial correlational analysis, comfort features of a walking environment were significantly and positively related to prevalence of obesity. When poverty was controlled with partial correlation, accessibility was significantly and negatively correlated with prevalence of waist-height ratio > 0.50. Conclusions The built environment merits further research to promote physical activity and stem the obesity epidemic in children. Our approach can be a useful framework for future research. PMID:25112374

  17. Basaltic lava flows covering active aeolian dunes in the Paraná Basin in southern Brazil: Features and emplacement aspects

    NASA Astrophysics Data System (ADS)

    Waichel, Breno L.; Scherer, Claiton M. S.; Frank, Heinrich T.

    2008-03-01

    Burial of active aeolian dunes by lava flows can preserve the morphology of the dunes and generate diverse features related to interaction between unconsolidated sediments and lavas. In the study area, located in southern Brazil, burial of aeolian deposits by Cretaceous basaltic lava flows completely preserved dunes, and generate sand-deformation features, sand diapirs and peperite-like breccia. The preserved dunes are crescentic and linear at the main contact with basalts, and smaller crescentic where interlayered with lavas. The various feature types formed on sediment surfaces by the advance of the flows reflect the emplacement style of the lavas which are compound pahoehoe type. Four feature types can be recognized: (a) type 1 features are related to the advance of sheet flows in dune-interdune areas with slopes > 5°, (b) type 2 is formed where the lava flows advance in lobes and climb the stoss slope of crescentic dunes (slopes 8-12°), (c) type 3 is generated by toes that descend the face of linear dunes (slopes 17-23°) and (d) type 4 occurs when lava lobes descend the stoss slope of crescentic dunes (slopes 10-15°). The direction of the flows, the disposition and morphology of the dunes and the ground slope are the main factors controlling formation of the features. The injection of unconsolidated sand in lava lobes forms diapirs and peperite-like breccias. Sand diapirs occur at the basal portion of lobes where the lava was more solidified. Peperite-like breccias occur in the inner portion where lava was more plastic, favoring the mingling of the components. The generation of both features is related to a mechanical process: the weight of the lava causes the injection of sand into the lava and the warming of the air in the pores of the sand facilitates this process. The lava-sediment interaction features presented here are consistent with previous reports of basalt lavas with unconsolidated arid sediments, and additional new sand-deformation features

  18. Phenomenological features of mortality and morbidity dynamics in Tomsk versus heliogeophysical activity

    NASA Astrophysics Data System (ADS)

    Borodin, A. S.; Tuzhilkin, D. A.; Gudina, M. V.; Vladimirsky, B. M.

    2015-12-01

    The influence of heliogeophysical activity on the morbidity and mortality of the population in Tomsk is studied epidemiologically on the basis of regional data. The biological effectiveness of heliogeophysical factors selected on the basis of the Karhunen-Loeve method from epidemiological data on the morbidity and mortality in Tomsk in 1990-2008 is estimated. An analysis of the impact of variations in heliogeophysical activity on morbidity and mortality (according to the International Statistical Classification of Diseases and Related Health, ICD-10) showed the existence of common factors within different nosological classes that reliably correlate with the major components of variations in characteristic indices of heliogeophysical activity.

  19. An Analysis of Activities in Saudi Arabian Middle School Science Textbooks and Workbooks for the Inclusion of Essential Features of Inquiry

    NASA Astrophysics Data System (ADS)

    Aldahmash, Abdulwali H.; Mansour, Nasser S.; Alshamrani, Saeed M.; Almohi, Saeed

    2016-01-01

    This study examines Saudi Arabian middle school science textbooks' coverage of the essential features of scientific inquiry. All activities in the middle school science textbooks and workbooks were analyzed by using the scientific inquiry `essential features' rubric. The results indicated that the essential features are included in about 59 % of the analyzed science activities. However, feature 2, `making learner give priority to evidence in responding to questions' and feature 3, `allowing learner to formulate explanations from evidence' appeared more frequently than the other three features (feature 1: engaging learner in scientifically oriented questions, feature 4: helping learner connect explanations to scientific knowledge, and feature 5: helping learner communicate and justify explanations to others), whether in the activities as a whole, or in the activities included in each of the four science domains (physical science, Earth science, life science and chemistry). These features are represented in almost all activities. This means that almost all activities in the middle school science textbooks and the workbooks include features 2 and 3. Meanwhile, the mean level of inclusion of the five essential features of scientific inquiry found in the middle school science textbooks and workbooks as a whole is 2.55. However, results found for features 1, 4, 5 and for in-level inclusion of the inquiry features in each of the science domains indicate that the inclusion of the essential inquiry features is teacher-centred. As a result, neither science textbooks nor workbooks provide students with the opportunity or encouragement to develop their inquiry skills. Consequently, the results suggest important directions for educational administrators and policy-makers in the preparation and use of science educational content.

  20. Emotion Recognition with Eigen Features of Frequency Band Activities Embedded in Induced Brain Oscillations Mediated by Affective Pictures.

    PubMed

    Aydin, Serap; Demirtaş, Serdar; Ateş, Kahraman; Tunga, M Alper

    2016-05-01

    In this study, singular spectrum analysis (SSA) has been used for the first time in order to extract emotional features from well-defined electroencephalography (EEG) frequency band activities (BAs) so-called delta (0.5-4 Hz), theta (4-8 Hz), alpha (8-16 Hz), beta (16-32 Hz), gamma (32-64 Hz). These five BAs were estimated by applying sixth-level multi-resolution wavelet decomposition (MRWD) with Daubechies wavelets (db-8) to single channel nonaveraged emotional EEG oscillations of 6 s for each scalp location over 16 recording sites (Fp1, Fp2, F3, F4, F7, F8, C3, C4, P3, P4, T3, T4, T5, T6, O1, O2). Every trial was mediated by different emotional stimuli which were selected from international affective picture system (IAPS) to induce emotional states such as pleasant (P), neutral (N), and unpleasant (UP). Largest principal components (PCs) of BAs were considered as emotional features and data mining approaches were used for the first time in order to classify both three different (P, N, UP) and two contrasting (P and UP) emotional states for 30 healthy controls. Emotional features extracted from gamma BAs (GBAs) for 16 recording sites provided the high classification accuracies of 87.1% and 100% for classification of three emotional states and two contrasting emotional states, respectively. In conclusion, we found the followings: (1) Eigenspectra of high frequency BAs in EEG are highly sensitive to emotional hemispheric activations, (2) emotional states are mostly mediated by GBA, (3) pleasant pictures induce the higher cortical activation in contrast to unpleasant pictures, (4) contrasting emotions induce opposite cortical activations, (5) cognitive activities are necessary for an emotion to occur. PMID:26971786

  1. The mediating role of facebook fan pages.

    PubMed

    Chih, Wen-Hai; Hsu, Li-Chun; Wang, Kai-Yu; Lin, Kuan-Yu

    2014-01-01

    Using the dual mediation hypothesis, this study investigates the role of interestingness (the power of attracting or holding one's attention) attitude towards the news, in the formation of Facebook Fan Page users' electronic word-of-mouth intentions. A total of 599 Facebook fan page users in Taiwan were recruited and structural equation modeling (SEM) was used to test the research hypotheses. The results show that both perceived news entertainment and informativeness positively influence interestingness attitude towards the news. Interestingness attitude towards the news subsequently influences hedonism and utilitarianism attitudes towards the Fan Page, which then influence eWOM intentions. Interestingness attitude towards the news plays a more important role than hedonism and utilitarianism attitudes in generating electronic word-of-mouth intentions. Based on the findings, the implications and future research suggestions are provided. PMID:24875695

  2. European user trial of paging by satellite

    NASA Technical Reports Server (NTRS)

    Fudge, R. E.; Fenton, C. J.

    1990-01-01

    British Telecom conceived the idea of adapting their existing paging service, together with the use of existing terrestrial pagers, to yield a one way data (i.e., paging) satellite service to mobiles. The user trial of paging by satellites was successful. It demonstrated that services could be provided over a wide geographical area to low priced terminals. Many lessons were learned in unexpected areas. These include the need for extensive liaison with all users involved, especially the drivers, to ensure they understood the potential benefits. There was a significant desire for a return acknowledgement channel or even a return data channel. Above all there is a need to ensure that the equipment can be taken across European borders and legitimately used in all European countries. The next step in a marketing assessment would be to consider the impact of two way data messaging such as INMARSAT-C.

  3. A rendering approach for stereoscopic web pages

    NASA Astrophysics Data System (ADS)

    Zhang, Jianlong; Wang, Wenmin; Wang, Ronggang; Chen, Qinshui

    2014-03-01

    Web technology provides a relatively easy way to generate contents for us to recognize the world, and with the development of stereoscopic display technology, the stereoscopic devices will become much more popular. The combination of web technology and stereoscopic display technology will bring revolutionary visual effect. The Stereoscopic 3D (S3D) web pages, in which text, image and video may have different depth, can be displayed on stereoscopic display devices. This paper presents the approach about how to render two viewing S3D web pages including text, images, widgets: first, an algorithm should be developed in order to display stereoscopic elements like text, widgets by using 2D graphic library; second, a method should be presented to render stereoscopic web page based on current framework of the browser; third, a rough solution is invented to fix the problem that comes out in the method.

  4. Ordinary and Activated Bone Grafts: Applied Classification and the Main Features

    PubMed Central

    Deev, R. V.; Drobyshev, A. Y.; Bozo, I. Y.; Isaev, A. A.

    2015-01-01

    Bone grafts are medical devices that are in high demand in clinical practice for substitution of bone defects and recovery of atrophic bone regions. Based on the analysis of the modern groups of bone grafts, the particularities of their composition, the mechanisms of their biological effects, and their therapeutic indications, applicable classification was proposed that separates the bone substitutes into “ordinary” and “activated.” The main differential criterion is the presence of biologically active components in the material that are standardized by qualitative and quantitative parameters: growth factors, cells, or gene constructions encoding growth factors. The pronounced osteoinductive and (or) osteogenic properties of activated osteoplastic materials allow drawing upon their efficacy in the substitution of large bone defects. PMID:26649300

  5. Incidental and context-responsive activation of structure- and function-based action features during object identification.

    PubMed

    Lee, Chia-lin; Middleton, Erica; Mirman, Daniel; Kalénine, Solène; Buxbaum, Laurel J

    2013-02-01

    Previous studies suggest that action representations are activated during object processing, even when task-irrelevant. In addition, there is evidence that lexical-semantic context may affect such activation during object processing. Finally, prior work from our laboratory and others indicates that function-based ("use") and structure-based ("move") action subtypes may differ in their activation characteristics. Most studies assessing such effects, however, have required manual object-relevant motor responses, thereby plausibly influencing the activation of action representations. The present work uses eyetracking and a Visual World Paradigm task without object-relevant actions to assess the time course of activation of action representations, as well as their responsiveness to lexical-semantic context. In two experiments, participants heard a target word and selected its referent from an array of four objects. Gaze fixations on nontarget objects signal activation of features shared between targets and nontargets. The experiments assessed activation of structure-based (Experiment 1) or function-based (Experiment 2) distractors, using neutral sentences ("S/he saw the....") or sentences with a relevant action verb (Experiment 1: "S/he picked up the...."; Experiment 2: "S/he used the...."). We observed task-irrelevant activations of action information in both experiments. In neutral contexts, structure-based activation was relatively faster-rising but more transient than function-based activation. Additionally, action verb contexts reliably modified patterns of activation in both Experiments. These data provide fine-grained information about the dynamics of activation of function-based and structure-based actions in neutral and action-relevant contexts, in support of the "Two Action System" model of object and action processing (e.g., Buxbaum & Kalénine, 2010). PMID:22390294

  6. SPAX - PAX with Super-Pages

    NASA Astrophysics Data System (ADS)

    Bößwetter, Daniel

    Much has been written about the pros and cons of column-orientation as a means to speed up read-mostly analytic workloads in relational databases. In this paper we try to dissect the primitive mechanisms of a database that help express the coherence of tuples and present a novel way of organizing relational data in order to exploit the advantages of both, the row-oriented and the column-oriented world. As we go, we break with yet another bad habit of databases, namely the equal granularity of reads and writes which leads us to the introduction of consecutive clusters of disk pages called super-pages.

  7. ActiveTutor: Towards More Adaptive Features in an E-Learning Framework

    ERIC Educational Resources Information Center

    Fournier, Jean-Pierre; Sansonnet, Jean-Paul

    2008-01-01

    Purpose: This paper aims to sketch the emerging notion of auto-adaptive software when applied to e-learning software. Design/methodology/approach: The study and the implementation of the auto-adaptive architecture are based on the operational framework "ActiveTutor" that is used for teaching the topic of computer science programming in first-grade…

  8. Making rainfall features fun: scientific activities for teaching children aged 5-12 years

    NASA Astrophysics Data System (ADS)

    Gires, Auguste; Muller, Catherine L.; le Gueut, Marie-Agathe; Schertzer, Daniel

    2016-05-01

    Research projects now rely on an array of different channels to increase impact, including high-level scientific output, tools, and equipment, but also communication, outreach, and educational activities. This paper focuses on education for children aged 5-12 years and presents activities that aim to help them (and their teachers) grasp some of the complex underlying issues in environmental science. More generally, it helps children to become familiarized with science and scientists, with the aim to enhance scientific culture and promote careers in this field. The activities developed are focused on rainfall: (a) designing and using a disdrometer to observe the variety of drop sizes; (b) careful recording of successive dry and rainy days and reproducing patterns using a simple model based on fractal random multiplicative cascades; and (c) collaboratively writing a children's book about rainfall. These activities are discussed in the context of current state-of-the-art pedagogical practices and goals set by project funders, especially in a European Union framework.

  9. Apple Treats. BASIC Classroom Computing Featuring Hands-On Activities and Pencil/Paper Fun.

    ERIC Educational Resources Information Center

    Embry, Lynn

    Developed as an introduction to computer programming using an Apple microcomputer, this document presents teachers and students with: (1) essential vocabulary used in the BASIC language; (2) syntax; and (3) programming techniques. Simple hands-on activities designed to guide the learner through beginning BASIC programming skills and fundamental…

  10. Distinct features of circulating microparticles and their relationship with disease activity in inflammatory bowel disease

    PubMed Central

    Voudoukis, Evangelos; Vetsika, Eleni-Kyriaki; Giannakopoulou, Konstantina; Karmiris, Konstantinos; Theodoropoulou, Angeliki; Sfiridaki, Aekaterini; Georgoulias, Vassilis; Paspatis, Gregorios A.; Koutroubakis, Ioannis E.

    2016-01-01

    Background There is evidence that circulating microparticles (MPs) and annexin (+) platelet-derived MPs (PDMPs) are increased in inflammatory bowel disease (IBD). The aim of our study was to characterize the abundance, origin, and annexin V binding of MPs in patients with IBD and correlate them with the disease characteristics. Methods Case-control study of 46 IBD patients (23 Crohn’s disease, 23 ulcerative colitis) and 40 matched healthy controls (HC). MPs were divided according to annexin V binding, their origin was estimated based on specific cell membrane markers in plasma samples and their number was calculated via flow cytometry. Clinical and laboratory activity indices were also analyzed. Results Annexin (-) PDMPs (P=0.0004), total (P=0.04) and annexin (+) monocyte-derived MPs (P=0.02) were increased and annexin (-) total MPs (P=0.0007) were decreased in IBD patients compared to HC. The annexin (+)/(-) ratio of all MP types were significantly elevated in IBD patients compared to HC (P<0.003). IBD patients with active disease displayed elevated total and annexin (+) total MPs, total, annexin (+) and (-) PDMPs compared with those in remission (P<0.05). Annexin (-) PDMPs were considerably increased in IBD patients with active compared to those with inactive disease (P=0.0013). Total and annexin (-) PDMPs were significantly correlated with most of the disease activity indices (P<0.05). Conclusion The majority of circulating MPs, their counterparts and particularly annexin (-) PDMPs are increased in active IBD patients. Annexin (+)/(-) ratio proved to be the most reliable distinctive MP index between HC and IBD patients. PMID:27065731

  11. Metabolic Features of Protochlamydia amoebophila Elementary Bodies – A Link between Activity and Infectivity in Chlamydiae

    PubMed Central

    Watzka, Margarete; Wultsch, Anna; Tziotis, Dimitrios; Montanaro, Jacqueline; Richter, Andreas; Schmitt-Kopplin, Philippe; Horn, Matthias

    2013-01-01

    The Chlamydiae are a highly successful group of obligate intracellular bacteria, whose members are remarkably diverse, ranging from major pathogens of humans and animals to symbionts of ubiquitous protozoa. While their infective developmental stage, the elementary body (EB), has long been accepted to be completely metabolically inert, it has recently been shown to sustain some activities, including uptake of amino acids and protein biosynthesis. In the current study, we performed an in-depth characterization of the metabolic capabilities of EBs of the amoeba symbiont Protochlamydia amoebophila. A combined metabolomics approach, including fluorescence microscopy-based assays, isotope-ratio mass spectrometry (IRMS), ion cyclotron resonance Fourier transform mass spectrometry (ICR/FT-MS), and ultra-performance liquid chromatography mass spectrometry (UPLC-MS) was conducted, with a particular focus on the central carbon metabolism. In addition, the effect of nutrient deprivation on chlamydial infectivity was analyzed. Our investigations revealed that host-free P. amoebophila EBs maintain respiratory activity and metabolize D-glucose, including substrate uptake as well as host-free synthesis of labeled metabolites and release of labeled CO2 from 13C-labeled D-glucose. The pentose phosphate pathway was identified as major route of D-glucose catabolism and host-independent activity of the tricarboxylic acid (TCA) cycle was observed. Our data strongly suggest anabolic reactions in P. amoebophila EBs and demonstrate that under the applied conditions D-glucose availability is essential to sustain metabolic activity. Replacement of this substrate by L-glucose, a non-metabolizable sugar, led to a rapid decline in the number of infectious particles. Likewise, infectivity of Chlamydia trachomatis, a major human pathogen, also declined more rapidly in the absence of nutrients. Collectively, these findings demonstrate that D-glucose is utilized by P. amoebophila EBs and provide

  12. Metabolic features of Protochlamydia amoebophila elementary bodies--a link between activity and infectivity in Chlamydiae.

    PubMed

    Sixt, Barbara S; Siegl, Alexander; Müller, Constanze; Watzka, Margarete; Wultsch, Anna; Tziotis, Dimitrios; Montanaro, Jacqueline; Richter, Andreas; Schmitt-Kopplin, Philippe; Horn, Matthias

    2013-01-01

    The Chlamydiae are a highly successful group of obligate intracellular bacteria, whose members are remarkably diverse, ranging from major pathogens of humans and animals to symbionts of ubiquitous protozoa. While their infective developmental stage, the elementary body (EB), has long been accepted to be completely metabolically inert, it has recently been shown to sustain some activities, including uptake of amino acids and protein biosynthesis. In the current study, we performed an in-depth characterization of the metabolic capabilities of EBs of the amoeba symbiont Protochlamydia amoebophila. A combined metabolomics approach, including fluorescence microscopy-based assays, isotope-ratio mass spectrometry (IRMS), ion cyclotron resonance Fourier transform mass spectrometry (ICR/FT-MS), and ultra-performance liquid chromatography mass spectrometry (UPLC-MS) was conducted, with a particular focus on the central carbon metabolism. In addition, the effect of nutrient deprivation on chlamydial infectivity was analyzed. Our investigations revealed that host-free P. amoebophila EBs maintain respiratory activity and metabolize D-glucose, including substrate uptake as well as host-free synthesis of labeled metabolites and release of labeled CO2 from (13)C-labeled D-glucose. The pentose phosphate pathway was identified as major route of D-glucose catabolism and host-independent activity of the tricarboxylic acid (TCA) cycle was observed. Our data strongly suggest anabolic reactions in P. amoebophila EBs and demonstrate that under the applied conditions D-glucose availability is essential to sustain metabolic activity. Replacement of this substrate by L-glucose, a non-metabolizable sugar, led to a rapid decline in the number of infectious particles. Likewise, infectivity of Chlamydia trachomatis, a major human pathogen, also declined more rapidly in the absence of nutrients. Collectively, these findings demonstrate that D-glucose is utilized by P. amoebophila EBs and provide

  13. Enhancing magnetic nanoparticle-based DNA transfection: Intracellular-active cassette features

    NASA Astrophysics Data System (ADS)

    Vernon, Matthew Martin

    Efficient plasmid DNA transfection of embryonic stem cells, mesenchymal stem cells, neural cell lines and the majority of primary cell lines is a current challenge in gene therapy research. Magnetic nanoparticle-based DNA transfection is a gene vectoring technique that is promising because it is capable of outperforming most other non-viral transfection methods in terms of both transfection efficiency and cell viability. The nature of the DNA vector implemented depends on the target cell phenotype, where the particle surface chemistry and DNA binding/unbinding kinetics of the DNA carrier molecule play a critical role in the many steps required for successful gene transfection. Accordingly, Neuromag, an iron oxide/polymer nanoparticle optimized for transfection of neural phenotypes, outperforms many other nanoparticles and lipidbased DNA carriers. Up to now, improvements to nanomagnetic transfection techniques have focused mostly on particle functionalization and transfection parameter optimization (cell confluence, growth media, serum starvation, magnet oscillation parameters, etc.). None of these parameters are capable of assisting the nuclear translocation of delivered plasmid DNA once the particle-DNA complex is released from the endosome and dissociates in the cell's cytoplasm. In this study, incorporation of a DNA targeting sequence (DTS) feature in the transfecting plasmid DNA confers improved nuclear translocation, demonstrating significant improvement in nanomagnetic transfection efficiency in differentiated SH-SY5Y neuroblastoma cells. Other parameters, such as days in vitro, are also found to play a role and represent potential targets for further optimization.

  14. Noticing relevant problem features: activating prior knowledge affects problem solving by guiding encoding

    PubMed Central

    Crooks, Noelle M.; Alibali, Martha W.

    2013-01-01

    This study investigated whether activating elements of prior knowledge can influence how problem solvers encode and solve simple mathematical equivalence problems (e.g., 3 + 4 + 5 = 3 + __). Past work has shown that such problems are difficult for elementary school students (McNeil and Alibali, 2000). One possible reason is that children's experiences in math classes may encourage them to think about equations in ways that are ultimately detrimental. Specifically, children learn a set of patterns that are potentially problematic (McNeil and Alibali, 2005a): the perceptual pattern that all equations follow an “operations = answer” format, the conceptual pattern that the equal sign means “calculate the total”, and the procedural pattern that the correct way to solve an equation is to perform all of the given operations on all of the given numbers. Upon viewing an equivalence problem, knowledge of these patterns may be reactivated, leading to incorrect problem solving. We hypothesized that these patterns may negatively affect problem solving by influencing what people encode about a problem. To test this hypothesis in children would require strengthening their misconceptions, and this could be detrimental to their mathematical development. Therefore, we tested this hypothesis in undergraduate participants. Participants completed either control tasks or tasks that activated their knowledge of the three patterns, and were then asked to reconstruct and solve a set of equivalence problems. Participants in the knowledge activation condition encoded the problems less well than control participants. They also made more errors in solving the problems, and their errors resembled the errors children make when solving equivalence problems. Moreover, encoding performance mediated the effect of knowledge activation on equivalence problem solving. Thus, one way in which experience may affect equivalence problem solving is by influencing what students encode about the

  15. Active site mapping of Loxosceles phospholipases D: Biochemical and biological features.

    PubMed

    Vuitika, L; Chaves-Moreira, D; Caruso, I; Lima, M A; Matsubara, F H; Murakami, M T; Takahashi, H K; Toledo, M S; Coronado, M A; Nader, H B; Senff-Ribeiro, A; Chaim, O M; Arni, R K; Veiga, S S

    2016-09-01

    Brown spider phospholipases D from Loxosceles venoms are among the most widely studied toxins since they induce dermonecrosis, triggering inflammatory responses, increase vascular permeability, cause hemolysis, and renal failure. The catalytic (H12 and H47) and metal-ion binding (E32 and D34) residues in Loxosceles intermedia phospholipase D (LiRecDT1) were mutated to understand their roles in the observed activities. All mutants were identified using whole venom serum antibodies and a specific antibody to wild-type LiRecDT1, they were also analyzed by circular dichroism (CD) and differential scanning calorimetry (DSC). The phospholipase D activities of H12A, H47A, H12A-H47A, E32, D34 and E32A-D34A, such as vascular permeability, dermonecrosis, and hemolytic effects were inhibited. The mutant Y228A was equally detrimental to biochemical and biological effects of phospholipase D, suggesting an essential role of this residue in substrate recognition and binding. On the other hand, the mutant C53A-C201A reduced the enzyme's ability to hydrolyze phospholipids and promote dermonecrosis, hemolytic, and vascular effects. These results provide the basis understanding the importance of specific residues in the observed activities and contribute to the design of synthetic and specific inhibitors for Brown spider venom phospholipases D. PMID:27233517

  16. Structural features and antioxidant activities of lignins from steam-exploded bamboo (Phyllostachys pubescens).

    PubMed

    Sun, Shao-Ni; Cao, Xue-Fei; Xu, Feng; Sun, Run-Cang; Jones, Gwynn Lloyd

    2014-06-25

    An environmentally friendly steam explosion process of bamboo, followed by alkali and alkaline ethanol delignification, was developed to fractionate lignins. Results showed that after steam explosion the lignins isolated showed relatively low carbohydrate contents (0.55-1.76%) and molecular weights (780-1050 g/mol). For each steam-exploded sample, alkali-extracted lignins presented higher phenolic OH values (1.41-1.82 mmol/g), p-coumaric acid to ferulic acid ratios (pCA/FA ratios 4.5-14.1), and syringyl to guaiacyl ratios (S/G ratios 5.0-8.5) than those from alkaline ethanol-extracted lignins (phenolic OH 0.85-1.35 mmol/g, pCA/FA ratios 1.6-5.2, and S/G ratios 3.5-4.8). The lignins obtained consisted mainly of β-O-4' linkages combined with small amounts of β-β', β-5', and α-O-4/β-O-4 linkages. Antioxidant activities of the lignins obtained were tested by the 2,2-diphenyl-1-picrylhydrazyl, 2,2'-azobis(3-ethylbenzothiazoline-6-sulfonic acid), and ferric reducing activity power methods. It was found that alkali-extracted lignins obtained during the initial extraction process had higher antioxidant activities than alkaline ethanol-extracted lignins obtained during the second extraction process. PMID:24927101

  17. The Luminous Polycyclic Aromatic Hydrocarbon Emission Features: Applications to High Redshift Galaxies and Active Galactic Nuclei

    NASA Astrophysics Data System (ADS)

    Shipley, Heath; Papovich, Casey

    2015-08-01

    We provide a new robust star-formation rate (SFR) calibration using the luminosity from polycyclic aromatic hydrogen (PAH) molecules. The PAH features emit strongly in the mid-infrared (mid-IR; 3-19μm), mitigating dust extinction, and they are very luminous, containing 5-10% of the total IR luminosity in galaxies. We derive the calibration of the PAH luminosity as a SFR indicator using a sample of 105 star-forming galaxies covering a range of total IR luminosity, LIR = L(8-1000μm) = 109 - 1012 L⊙ and redshift 0 < z < 0.6. The PAH luminosity correlates linearly with the SFR as measured by the dust-corrected Hα luminosity (using the sum of the Hα and rest-frame 24μm luminosity from Kennicutt et al. 2009), with tight scatter of ~0.15 dex, comparable to the scatter in the dust-corrected Hα SFRs and Paα SFRs. We show this relation is sensitive to galaxy metallicity, where the PAH luminosity of galaxies with Z < 0.7 Z⊙ departs from the linear SFR relationship but in a behaved manor. We derive for this a correction to galaxies below solar metallicity. As a case study for observations with JWST, we apply the PAH SFR calibration to a sample of lensed galaxies at 1 < z < 3 with Spitzer Infrared Spectrograph (IRS) data, and we demonstrate the utility of PAHs to derive SFRs as accurate as those available from any other indicator. This new SFR indicator will be useful for probing the peak of the SFR density of the universe (1 < z < 3) and for studying the coevolution of star-formation and supermassive blackhole accretion contemporaneously in a galaxy.

  18. Let's Meet Famous Artists. A Creative Art Activity Book. A Teacher's Guide Featuring 19 Famous Artists and Art Activities.

    ERIC Educational Resources Information Center

    Kinghorn, Harriet; And Others

    By studying the lives, important achievements, and works of famous artists, students may come to understand what those artists hoped to communicate to the world. By participating in art activities that are related to these artists' styles, students practice skills of observing, analyzing, and creating. This instructional guide provides…

  19. Classic to Contemporary: Famous Artists and Activities. A Teacher's Guide Featuring 19 Famous Artists' Biographies and Enrichment/Research Activities.

    ERIC Educational Resources Information Center

    Kinghorn, Harriet; Lewis-Spicer, Lisa

    By studying the lives, important achievements, and works of famous artists, students may come to understand what those artists hoped to communicate to the world. By participating in art activities that are related to these artists' styles, students practice skills of observing, analyzing, and creating. This instructional guide provides…

  20. Using Database-Driven Web Pages for Your Courses.

    ERIC Educational Resources Information Center

    Sullivan, Peter

    1999-01-01

    Describes database-driven Web pages that dynamically display different information each time the page is accessed in response to the user's needs. Highlights include information management; online assignments; grade tracking; updating Web pages; creating database-driven Web pages; and examples of how they have been used for a high school physics…

  1. 24 CFR 1710.105 - Cover page.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 5 2014-04-01 2014-04-01 false Cover page. 1710.105 Section 1710.105 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND...

  2. Turning the Page with Preconference Workshops

    ERIC Educational Resources Information Center

    Knowledge Quest, 2011

    2011-01-01

    For those who are experiencing a lack of creative inspiration within their school library program but are ready to "turn a page" in their career or school library program, they may head to Minneapolis to attend one of the many great preconference workshops. This article presents and describes preconference workshops design to rid librarians of the…

  3. Reconfigurable Full-Page Braille Displays

    NASA Technical Reports Server (NTRS)

    Garner, H. Douglas

    1994-01-01

    Electrically actuated braille display cells of proposed type arrayed together to form full-page braille displays. Like other braille display cells, these provide changeable patterns of bumps driven by digitally recorded text stored on magnetic tapes or in solid-state electronic memories. Proposed cells contain electrorheological fluid. Viscosity of such fluid increases in strong electrostatic field.

  4. Thomas Jefferson, Page Design, and Desktop Publishing.

    ERIC Educational Resources Information Center

    Hartley, James

    1991-01-01

    Discussion of page design for desktop publishing focuses on the importance of functional issues as opposed to aesthetic issues, and criticizes a previous article that stressed aesthetic issues. Topics discussed include balance, consistency in text structure, and how differences in layout affect the clarity of "The Declaration of Independence."…

  5. Policy Analysis of the Greenhouse Effect (PAGE)

    EPA Science Inventory

    PAGE09 is a spreadsheet probabilistic model written in Microsoft Office Excel. The model calculates regional and global impacts of climate change, and social costs of different greenhouse gases. It also calculates the costs of abatement and adaptation. It is an Integrated Assessm...

  6. Adding Graphics to Your WWW Page.

    ERIC Educational Resources Information Center

    Descy, Don E.

    1995-01-01

    Explains how to retrieve graphics that are available on the World Wide Web and add them to a Web page using a word processor that can save documents in an ASCII (American Standard Code Information Interchange) text format and a new version of Netscape. A list of various, unrelated Internet resources is also included. (LRW)

  7. Women's Page Editors: Self-Perceived Status.

    ERIC Educational Resources Information Center

    Chang, Won; And Others

    The focal points of this study are the role perceptions and the environments of women's page editors from daily and weekly newspapers across the United States. In the role perception areas, equal rights, discrimination, and the role of women in journalism are examined. Salaries, education, college major and minor, and years in the profession are…

  8. Efficient Web Change Monitoring with Page Digest

    SciTech Connect

    Buttler, D J; Rocco, D; Liu, L

    2004-02-20

    The Internet and the World Wide Web have enabled a publishing explosion of useful online information, which has produced the unfortunate side effect of information overload: it is increasingly difficult for individuals to keep abreast of fresh information. In this paper we describe an approach for building a system for efficiently monitoring changes to Web documents. This paper has three main contributions. First, we present a coherent framework that captures different characteristics of Web documents. The system uses the Page Digest encoding to provide a comprehensive monitoring system for content, structure, and other interesting properties of Web documents. Second, the Page Digest encoding enables improved performance for individual page monitors through mechanisms such as short-circuit evaluation, linear time algorithms for document and structure similarity, and data size reduction. Finally, we develop a collection of sentinel grouping techniques based on the Page Digest encoding to reduce redundant processing in large-scale monitoring systems by grouping similar monitoring requests together. We examine how effective these techniques are over a wide range of parameters and have seen an order of magnitude speed up over existing Web-based information monitoring systems.

  9. 24 CFR 1710.105 - Cover page.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 5 2011-04-01 2011-04-01 false Cover page. 1710.105 Section 1710.105 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... DEVELOPMENT (INTERSTATE LAND SALES REGISTRATION PROGRAM) LAND REGISTRATION Reporting Requirements §...

  10. 24 CFR 1710.105 - Cover page.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Cover page. 1710.105 Section 1710.105 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... DEVELOPMENT (INTERSTATE LAND SALES REGISTRATION PROGRAM) LAND REGISTRATION Reporting Requirements §...

  11. What's Not Funny about the Funny Pages?

    ERIC Educational Resources Information Center

    Lum, Lydia

    2008-01-01

    As a kid, Darrin Bell devoured newspaper comic strips. So it was disappointing whenever editors refused years later to add his comic strip, "Candorville," to their funny pages as soon as they saw that his lead characters were minorities. The editors would say they already carried a so-called Black strip. It is difficult for cartoonists like Bell…

  12. Testing of an actively damped boring bar featuring structurally integrated PZT stack actuators

    SciTech Connect

    Redmond, J.; Barney, P.

    1998-06-01

    This paper summarizes the results of cutting tests performed using an actively damped boring bar to minimize chatter in metal cutting. A commercially available 2 inch diameter boring bar was modified to incorporate PZT stack actuators for controlling tool bending vibrations encountered during metal removal. The extensional motion of the actuators induce bending moments in the host structure through a two-point preloaded mounting scheme. Cutting tests performed at various speeds and depths of cuts on a hardened steel workpiece illustrate the bar`s effectiveness toward eliminating chatter vibrations and improving workpiece surface finish.

  13. Hydroxycinnamic acid bound arabinoxylans from millet brans-structural features and antioxidant activity.

    PubMed

    Bijalwan, Vandana; Ali, Usman; Kesarwani, Atul Kumar; Yadav, Kamalendra; Mazumder, Koushik

    2016-07-01

    Hydroxycinnamic acid bound arabinoxylans (HCA-AXs) were extracted from brans of five Indian millet varieties and response surface methodology was used to optimize the extraction conditions. The optimal condition to obtain highest yield of millet HCA-AXs was determined as follows: time 61min, temperature 66°C, ratio of solvent to sample 12ml/g. Linkage analysis indicated that hydroxycinnamic acid bound arabinoxylan from kodo millet (KM-HCA-AX) contained comparatively low branched arabinoxylan consisting of 14.6% mono-substituted, 1.2% di-substituted and 41.2% un-substituted Xylp residues. The HPLC analysis of millet HCA-AXs showed significant variation in the content of three major bound hydroxycinnamic acids (caffeic, p-coumaric and ferulic acid). The antioxidant activity of millet HCA-AXs were evaluated using three in vitro assay methods (DPPH, FRAP and β-carotene linoleate emulsion assays) which suggested both phenolic acid composition and structural characteristics of arabinoxylans could be correlated to their antioxidant potential, the detailed structural analysis revealed that low substituted KM-HCA-AX exhibited relatively higher antioxidant activity compared to other medium and highly substituted HCA-AXs from finger (FM), proso (PM), barnyard (BM) and foxtail (FOXM) millet. PMID:27050114

  14. [Features of brain oscillatory activity and cardiac defense in treatment arterial hypertensives].

    PubMed

    Aftanas, L I; Brak, I V; Gilinskaia, O M; Pavlov, S V; Reva, N V

    2014-01-01

    Stress reactivity of the motivational system of defense can be assessed with the aid the cardiac defense response (CDR) - the reaction of the cardiovascular system to unexpected aversive unconditioned stimulus. The main objective of the study was revealing putative contribution of oscillatory systems of the brain into central pathogenic mechanisms of enhanced blood pressure (BP) stress-reactivity in naive patients with arterial hypertension (AH) of the 1st-2nd degrees (n = 17) and healthy control (n = 19) subjects. Using dynamic registration "beat-by-beat" arterial pressure, and oscillatory activity related EEG (64 channels) is estimated using the event-related synchronization/desynchronization (ERD/ERS). Along with abnormally high blood pressure in patients with hypertension background set significantly lower concentrations of serotonin blood platelets and increased tonic activation of the left hemisphere, reflected in the asymmetric reduction of delta- (2-4 Hz) and theta-1 (4-6 Hz) power in the central and parietal cortex in the hemisphere CDR of the patients are characterized by hyperactivity both short- and long-latency components of blood pressure. According to the dynamic analysis of the concomitant EEG, long-latency BP components may be accounted by, among other mechanisms, weakening of the descending ("top-down") inhibitory control, hypothetically implemented with the high-frequency EEG alpha (10-12 Hz) oscillations from the medial central-parietal cortex of both hemispheres of the brain. PMID:25464727

  15. Clinical features of active tuberculosis that developed during anti-tumor necrosis factor therapy in patients with inflammatory bowel disease

    PubMed Central

    Lee, Jang Wook; Park, Ji Hoon; Kim, Jeong Wook; Kang, Sang Bum; Koo, Ja Seol; Kim, Young-Ho; Kim, You Sun; Joo, Young Eun; Chang, Sae Kyung

    2016-01-01

    Background/Aims Anti-tumor necrosis factor (TNF) therapy for active ulcerative colitis (UC) and Crohn's disease (CD) is associated with increased risks of tuberculosis (TB) infection. We analyzed the incidence and clinical features of Korean patients with inflammatory bowel disease (IBD) who developed active TB during anti-TNF therapy. Methods Ten cases of active TB developed in patients treated with infliximab (n=592) or adalimumab (n=229) for UC (n=160) or CD (n=661) were reviewed. We analyzed demographics, interval between start of anti-TNF therapy and active TB development, tests for latent TB infection (LTBI), concomitant medications, and the details of diagnosis and treatments for TB. Results The incidence of active TB was 1.2% (10/821): 1.5% (9/592) and 0.4% (1/229) in patients receiving infliximab and adalimumab, respectively. The median time to the development of active TB after initiation of anti-TNF therapy was three months (range: 2–36). Three patients had past histories of treatment for TB. Positive findings in a TB skin test (TST) and/or interferon gamma releasing assay (IGRA) were observed in three patients, and two of them received anti-TB prophylaxis. Two patients were negative by both TST and IGRA. The most common site of active TB was the lungs, and the active TB was cured in all patients. Conclusions Active TB can develop during anti-TNF therapy in IBD patients without LTBI, and even in those with histories of TB treatment or LTBI prophylaxis. Physicians should be aware of the potential for TB development during anti-TNF therapy, especially in countries with a high prevalence of TB. PMID:27175115

  16. Transgenerational transmission of systemic mast cell activation disease-genetic and epigenetic features.

    PubMed

    Molderings, Gerhard J

    2016-08-01

    Systemic mast cell activation disease (MCAD) comprises disorders characterized by an enhanced release of mast cell mediators accompanied by a varying accumulation of dysfunctional mast cells. Within the last years, evidence has been presented that MCAD is a multifactorial polygenic determined disease with the KIT(D816V) mutation and its induced functional consequences considered as special case. The respective genes encode proteins for various signaling pathways, epigenetic regulators, the RNA splicing machinery, and transcription factors. Transgenerational transmission of MCAD appears to be quite common. The basics of the molecular mechanisms underlying predisposition of the disease, that is, somatic and germline mutations and the contribution of epigenetic processes have become identifiable. The aim of the present review is to present and discuss available genetic, epigenetic and epidemiological findings, and to present a model of MCAD pathogenesis. PMID:26880691

  17. Initial heats of H{sub 2}S adsorption on activated carbons: Effect of surface features

    SciTech Connect

    Bagreev, A.; Adib, F.; Bandosz, T.J.

    1999-11-15

    The sorption of hydrogen sulfide was studied on activated carbons of various origins by means of inverse gas chromatography at infinite dilution. The conditions of the experiment were dry and anaerobic. Prior to the experiments the surface of some carbon samples was oxidized using either nitric acid or ammonium persulfate. Then the structural parameters of carbons were evaluated from the sorption of nitrogen. From the IGC experiments at various temperatures, heats of adsorption were calculated. The results showed that the heat of H{sub 2}S adsorption under dry anaerobic conditions does not depend on surface chemistry. The dependence of the heat of adsorption on the characteristic energy of nitrogen adsorption calculated from the Dubinin-Raduskevich equation was found. This correlation can be used to predict the heat of H{sub 2}S adsorption based on the results obtained from nitrogen adsorption.

  18. Performance analysis of a semi-active railway vehicle suspension featuring MR dampers

    NASA Astrophysics Data System (ADS)

    Kim, Hwan-Choong; Choi, Seung-Bok; Lee, Gyu-Seop; An, Chae-Hun; You, Won-Hee

    2014-03-01

    This paper presents performance analysis of semi-active railway vehicle suspension system using MR damper. In order to achieve this goal, a mathematical dynamic model of railway vehicle is derived by integrating car body, bogie frame and wheel-set which can be able to represent lateral, yaw and roll motion. Based on this model, the dynamic range of MR damper at the railway secondary suspension system and design parameters of MR damper are calculated. Subsequently, control performances of railway vehicle including car body lateral motion and acceleration of MR damper are evaluated through computer simulations. Then, the MR damper is manufactured to be retrofitted with the real railway vehicle and its characteristics are experimentally measured. Experimental performance of MR damper is assessed using test rig which is composed of a car body and two bogies.

  19. A design study of a photorefractive page composer

    NASA Technical Reports Server (NTRS)

    1975-01-01

    A laboratory demonstration and preliminary system analysis of a page composer designed to have the dual advantages of low optical loss and small size, were reported. The current page composer is optically addressed and functions by virtue of optically induced refractive index changes in the active material. Laboratory demonstrations of the device were successfully performed using 10 x 10 bit and 128 x 128 bit data arrays. It was established that the only significant obstacle to the construction of a brass-board model working at megabit data rates is the lack of sensitivity of the photorefractive materials which were considered during the course of this study. Possible materials for future consideration are the photoplastics. While they have more than the required sensitivity, their stability and suitability for double exposure holography was not investigated. If a sufficiently sensitive material is found, then the photorefractive page composer could be built to perform in a highly efficient fashion which would result in a overall reduction of the size of the memory system and an easing of the requirements upon the sensitivity of the holographic recording material.

  20. Crevasse-squeeze ridge corridors: Diagnostic features of late-stage palaeo-ice stream activity

    NASA Astrophysics Data System (ADS)

    Evans, David J. A.; Storrar, Robert D.; Rea, Brice R.

    2016-04-01

    A 200-km-long and 10-km-wide linear assemblage of till-filled geometrical ridges on the bed of the Maskwa palaeo-ice stream of the late Wisconsinan southwest Laurentide Ice Sheet are interpreted as crevasse-squeeze ridges (CSR) developed during internal flow unit reorganization, immediately prior to ice stream shutdown. Ridge orientations are predominantly orientated WNW-ESE, with a subordinate WSW-ENE alignment, both indicative of ice fracture development transverse to former ice stream flow, as indicated by NNE-SSW aligned MSGL. Subglacial till injection into basal and/or full depth, mode I and II crevasses occurred at the approximate centreline of the ice stream, in response to extension and fracturing. Landform preservation indicates that this took place during the final stages of ice streaming, immediately prior to ice stream shutdown. This linear zone of ice fracturing therefore likely represents the narrowing of the fast-flowing trunk, similar to the plug flow identified in some surging valley glaciers. Lateral drag between the final active flow unit and the slower moving ice on either side is likely recorded by the up-ice bending of the CSR limbs. The resulting CSR corridor, here related to an individual ice stream flow unit, constitutes a previously unreported style of crevasse infilling and contrasts with two existing CSR patterns: (1) wide arcuate zones of CSRs related to widespread fracturing within glacier surge lobes; and (2) narrow concentric arcs of CSRs and recessional push moraines related to submarginal till deformation at active temperate glacier lobes.

  1. Variability of the X-ray broad iron spectral features in active galactic nuclei and black-hole binaries

    NASA Astrophysics Data System (ADS)

    Mizumoto, M.; Ebisawa, K.; Tsujimoto, M.; Inoue, H.

    2016-05-01

    The ``broad iron spectral features'' are often seen in X-ray spectra of active galactic nuclei (AGN) and black-hole binaries (BHB). These features may be explained either by the ``relativistic disc reflection'' scenario or the ``partial covering'' scenario: It is hardly possible to determine which model is valid from time-averaged spectral analysis. Thus, X-ray spectral variability has been investigated to constrain spectral models. To that end, it is crucial to study iron structure of BHBs in detail at short time-scales, which is, for the first time, made possible with the Parallel-sum clocking (P-sum) mode of XIS detectors on board of Suzaku. This observational mode has a time-resolution of 7.8 ms as well as a CCD energy-resolution. We have carried out systematic calibration of the P-sum mode, and investigated spectral variability of the BHB GRS 1915+105. Consequently, we found that the spectral variability of GRS 1915+105 does not show iron features at sub-seconds. This is totally different from variability of AGN such as 1H0707-495, where the variation amplitude significantly drops at the iron K-energy band. This difference can be naturally explained in the framework of the ``partial covering'' scenario.

  2. Are safety-related features of the road environment associated with smaller declines in physical activity among youth?

    PubMed

    Carver, Alison; Timperio, Anna; Hesketh, Kylie; Crawford, David

    2010-01-01

    This study examined how objective measures of the local road environment related to safety were associated with change in physical activity (including active transport) among youth. Few longitudinal studies have examined the impact of the road environment on physical activity among children/adolescents in their neighborhoods. Participants were children aged 8-9 years (n = 170) and adolescents aged 13-15 years (n = 276) in 2004. Data were collected in 2004 and 2006 during follow-up of participants recruited initially in 2001 from 19 primary schools in Melbourne, Australia. Walking/cycling to local destinations was parent-reported for children and self-reported by adolescents. Moderate-to-vigorous physical activity (MVPA) during nonschool hours was recorded using accelerometers. Road environment features in each participant's neighborhood (area within 800 m radius of their home) were measured objectively using a Geographical Information System. Linear regression analyses examined associations between road features and changes in active transport (AT) and MVPA over 2 years. Children's AT increased but MVPA levels decreased in both age groups; on average, younger girls recorded the greatest declines. The number of traffic/pedestrian lights was associated with DeltaAT among younger girls (B=0.45, p=0.004). The total length of walking tracks (in meters) was associated with AT among younger girls (B = 0.0016, p = 0.015) and adolescent girls (B = 0.0016, p = 0.002). For adolescent boys, intersection density was associated with AT (B = 0.03, p = 0.030). Slow points were associated with MVPA among younger boys before school (B = 1.55, p = 0.021), while speed humps were associated with MVPA among adolescent boys after school (B = 0.23, p = 0.015). There were many associations for adolescent girls: for example, the total length of local roads (B = 0.49, p = 0.005), intersection density (B = 0.05, p = 0.036), and number of speed humps (B = 0.33, p = 0.020) were associated with

  3. Study of Fractal Features of Geomagnetic Activity Through an MHD Shell Model

    NASA Astrophysics Data System (ADS)

    Dominguez, M.; Nigro, G.; Munoz, V.; Carbone, V.

    2013-12-01

    Studies on complexity have been of great interest in plasma physics, because they provide new insights and reveal possible universalities on issues such as geomagnetic activity, turbulence in laboratory plasmas, physics of the solar wind, etc. [1, 2]. In particular, various studies have discussed the relationship between the fractal dimension, as a measure of complexity, and physical processes in magnetized plasmas such as the Sun's surface, the solar wind and the Earth's magnetosphere, including the possibility of forecasting geomagnetic activity [3, 4, 5]. Shell models are low dimensional dynamical models describing the main statistical properties of magnetohydrodynamic (MHD) turbulence [6]. These models allow us to describe extreme parameter conditions hence reaching very high Reynolds (Re) numbers. In this work a MHD shell model is used to describe the dissipative events which are taking place in the Earth's magnetosphere and causing geomagnetic storms. The box-counting fractal dimension (D) [7] is calculated for the time series of the magnetic energy dissipation rate obtained in this MHD shell model. We analyze the correlation between D and the energy dissipation rate in order to make a comparison with the same analysis made on the geomagnetic data. We show that, depending on the values of the viscosity and the diffusivity, the fractal dimension and the occurrence of bursts exhibit correlations similar as those observed in geomagnetic and solar data, [8] suggesting that the latter parameters could play a fundamental role in these processes. References [1] R. O. Dendy, S. C. Chapman, and M. Paczuski, Plasma Phys. Controlled Fusion 49, A95 (2007). [2] T. Chang and C. C. Wu, Phys. Rev. E 77, 045401 (2008). [3] R. T. J. McAteer, P. T. Gallagher, and J. Ireland, Astrophys. J. 631, 628 (2005). [4] V. M. Uritsky, A. J. Klimas, and D. Vassiliadis, Adv. Space Res. 37, 539 (2006). [5] S. C. Chapman, B. Hnat, and K. Kiyani, Nonlinear Proc. Geophys. 15, 445 (2008). [6] G

  4. Features of artificial ULF/VLF signals induced by SURA facility under increased solar activity conditions

    NASA Astrophysics Data System (ADS)

    Kotik, Dmitry; Ryabov, Alexander; Pershin, Alexsander; Ermakova, Elena

    It was conducted a comprehensive study of artificial ionospheric signal generation in the ULF/VLF bands at SURA facility during the past four years. We investigated the influence of geomagnetic activity on the characteristics of artificial low-frequency signals in recent years under the background of increasing solar activity. No correlation with variations of Earth's magnetic field was observed for weak geomagnetic disturbances (Kp < 3). It was observed decreasing in the amplitude of signals at frequencies of 3 and 6 Hz, while the VLF signals at frequencies of 2 and 2.6 kHz increased for growth phase of the geomagnetic field perturbations during a small magnetic storms October 7, 2011 (Ki = 4 according to Moscow station). A similar pattern was traced in 2013 during storms March 21 (Kp = 5), May 24-25 (Kp = 5 +) and August 16 (Kp = 5 +). There are two possible reasons for the observed dependence - increasing the absorption of HF and VLF waves in the lower ionosphere, and / or reduction of the critical frequency of the F-layer, usually accompanied by a magnetic storm. The last factor is perhaps the most likely. This dependence was traced more convincingly on May 24-25, when during a storm time SURE had operated from evening until 6:00 MST in the morning. Signal amplitude explicitly followed the F- layer critical frequency variation. Some of the measurements in June 2012 were conducted during a magnetic storm on June 16-18, (Kp = 6). It was also found a decrease in the amplitude of the signal at the rise of the magnetic disturbance. In addition, during the daytime session 18.06.2012 during the recovery phase, it was detected modulation of artificial signals at frequencies 11 and 17 Hz with a period of 30 seconds. Note that the period of 30s is the main period of oscillation of the geomagnetic field line passing through the SURA facility, and more, the periods for torsional and the toroidal oscillation modes of this field line surprising coincidence for SURA

  5. More target features in visual working memory leads to poorer search guidance: Evidence from contralateral delay activity

    PubMed Central

    Schmidt, Joseph; MacNamara, Annmarie; Proudfit, Greg Hajcak; Zelinsky, Gregory J.

    2014-01-01

    The visual-search literature has assumed that the top-down target representation used to guide search resides in visual working memory (VWM). We directly tested this assumption using contralateral delay activity (CDA) to estimate the VWM load imposed by the target representation. In Experiment 1, observers previewed four photorealistic objects and were cued to remember the two objects appearing to the left or right of central fixation; Experiment 2 was identical except that observers previewed two photorealistic objects and were cued to remember one. CDA was measured during a delay following preview offset but before onset of a four-object search array. One of the targets was always present, and observers were asked to make an eye movement to it and press a button. We found lower magnitude CDA on trials when the initial search saccade was directed to the target (strong guidance) compared to when it was not (weak guidance). This difference also tended to be larger shortly before search-display onset and was largely unaffected by VWM item-capacity limits or number of previews. Moreover, the difference between mean strong- and weak-guidance CDA was proportional to the increase in search time between mean strong-and weak-guidance trials (as measured by time-to-target and reaction-time difference scores). Contrary to most search models, our data suggest that trials resulting in the maintenance of more target features results in poor search guidance to a target. We interpret these counterintuitive findings as evidence for strong search guidance using a small set of highly discriminative target features that remain after pruning from a larger set of features, with the load imposed on VWM varying with this feature-consolidation process. PMID:24599946

  6. A Statistical Study of Different Solar Activity Features with Total column Ozone at two hill stations of Uttarakhand, India

    NASA Astrophysics Data System (ADS)

    Pande, Seema

    Abstract:\\underline{} In this study, we have presented a statistical study of different solar activity features (DSAF) like sunspot number, solar active prominences, solar flares and solar energetic particle events (SEPs) with total column ozone amount using 28 years (1986-2013) data. The ozone data has been taken for two hill stations of Uttarakhand i.e. Nainital (29º 23’N, 79º27’E) and Mussoorie (30° 27' N, 78° 06' E). Graphs are plotted between Total column Ozone (TCO) and DSAF for months January to December annually. Positive correlation coefficient is obtained between TCO and sunspot number by using linear curve fitting method. We have also compared the SEPs intensity with the TCO for above two mentioned cities.

  7. Structural features that specify tyrosine kinase activity deduced from homology modeling of the epidermal growth factor receptor.

    PubMed Central

    Knighton, D R; Cadena, D L; Zheng, J; Ten Eyck, L F; Taylor, S S; Sowadski, J M; Gill, G N

    1993-01-01

    To identify structural features that distinguish protein-tyrosine kinases from protein-serine kinases, a molecular model of the kinase domain of epidermal growth factor receptor was constructed by substituting its amino acid sequence for the amino acid sequence of the catalytic subunit of cAMP-dependent protein kinase in a 2.7-A refined crystallographic model. General folding was conserved as was the configuration of invariant residues at the active site. Two sequence motifs that distinguish the two families correspond to loops that converge at the active site of the enzyme. A conserved arginine in the catalytic loop is proposed to interact with the gamma phosphate of ATP. The second loop provides a binding surface that positions the tyrosine of the substrate. A positively charged surface provides additional sites for substrate recognition. Images Fig. 2 Fig. 3 Fig. 4 PMID:8389462

  8. Resistance to Degradation and Cellular Distribution are Important Features for the Antitumor Activity of Gomesin

    PubMed Central

    Buri, Marcus V.; Domingues, Tatiana M.; Paredes-Gamero, Edgar J.; Casaes-Rodrigues, Rafael L.; Rodrigues, Elaine Guadelupe; Miranda, Antonio

    2013-01-01

    Many reports have shown that antimicrobial peptides exhibit anticancer abilities. Gomesin (Gm) exhibits potent cytotoxic activity against cancer cells by a membrane pore formation induced after well-orchestrated intracellular mechanisms. In this report, the replacements of the Cys by Ser or Thr, and the use D-amino acids in the Gm structure were done to investigate the importance of the resistance to degradation of the molecule with its cytotoxicity. [Thr2,6,11,15]-Gm, and [Ser2,6,11,15]-Gm exhibits low cytotoxicity, and low resistance to degradation, and after 24 h are present in localized area near to the membrane. Conversely, the use of D-amino acids in the analogue [D-Thr2,6,11,15]-D-Gm confers resistance to degradation, increases its potency, and maintained this peptide spread in the cytosol similarly to what happens with Gm. Replacements of Cys by Thr and Gln by L- or D-Pro ([D-Thr2,6,11,15, Pro9]-D-Gm, and [Thr2,6,11,15, D-Pro9]-Gm), which induced a similar β-hairpin conformation, also increase their resistance to degradation, and cytotoxicity, but after 24 h they are not present spread in the cytosol, exhibiting lower cytotoxicity in comparison to Gm. Additionally, chloroquine, a lysosomal enzyme inhibitor potentiated the effect of the peptides. Furthermore, the binding and internalization of peptides was determined, but a direct correlation among these factors was not observed. However, cholesterol ablation, which increase fluidity of cellular membrane, also increase cytotoxicity and internalization of peptides. β-hairpin spatial conformation, and intracellular localization/target, and the capability of entry are important properties of gomesin cytotoxicity. PMID:24312251

  9. Structural Features and Chaperone Activity of the NudC Protein Family

    SciTech Connect

    Zheng, Meiying; Cierpicki, Tomasz; Burdette, Alexander J.; Utepbergenov, Darkhan; Janczyk, Pawe; #322; #321; .; Derewenda, Urszula; Stukenberg, P. Todd; Caldwell, Kim A.; Derewenda, Zygmunt S.

    2012-05-25

    The NudC family consists of four conserved proteins with representatives in all eukaryotes. The archetypal nudC gene from Aspergillus nidulans is a member of the nud gene family that is involved in the maintenance of nuclear migration. This family also includes nudF, whose human orthologue, Lis1, codes for a protein essential for brain cortex development. Three paralogues of NudC are known in vertebrates: NudC, NudC-like (NudCL), and NudC-like 2 (NudCL2). The fourth distantly related member of the family, CML66, contains a NudC-like domain. The three principal NudC proteins have no catalytic activity but appear to play as yet poorly defined roles in proliferating and dividing cells. We present crystallographic and NMR studies of the human NudC protein and discuss the results in the context of structures recently deposited by structural genomics centers (i.e., NudCL and mouse NudCL2). All proteins share the same core CS domain characteristic of proteins acting either as cochaperones of Hsp90 or as independent small heat shock proteins. However, while NudC and NudCL dimerize via an N-terminally located coiled coil, the smaller NudCL2 lacks this motif and instead dimerizes as a result of unique domain swapping. We show that NudC and NudCL, but not NudCL2, inhibit the aggregation of several target proteins, consistent with an Hsp90-independent heat shock protein function. Importantly, and in contrast to several previous reports, none of the three proteins is able to form binary complexes with Lis1. The availability of structural information will be of help in further studies on the cellular functions of the NudC family.

  10. Phenotypic, functional, and plasticity features of classical and alternatively activated human macrophages.

    PubMed

    Tarique, Abdullah A; Logan, Jayden; Thomas, Emma; Holt, Patrick G; Sly, Peter D; Fantino, Emmanuelle

    2015-11-01

    Macrophages are dynamic cells that mature under the influence of signals from the local microenvironment into either classically (M1) or alternatively (M2) activated macrophages with specific functional and phenotypic properties. Although the phenotypic identification of M1 and M2 macrophages is well established in mice, this is less clear for human macrophages. In addition, the persistence and reversibility of polarized human phenotypes is not well established. Human peripheral blood monocytes were differentiated into uncommitted macrophages (M0) and then polarized to M1 and M2 phenotypes using LPS/IFN-γ and IL-4/IL-13, respectively. M1 and M2 were identified as CD64(+)CD80(+) and CD11b(+)CD209(+), respectively, by flow cytometry. Polarized M1 cells secreted IP-10, IFN-γ, IL-8, TNF-α, IL-1β, and RANTES, whereas M2 cells secreted IL-13, CCL17, and CCL18. Functionally, M2 cells were highly endocytic. In cytokine-deficient medium, the polarized macrophages reverted back to the M0 state within 12 days. If previously polarized macrophages were given the alternative polarizing stimulus after 6 days of resting in cytokine-deficient medium, a switch in polarization was seen (i.e., M1 macrophages switched to M2 and expressed CD11b(+)CD209(+) and vice versa). In summary, we report phenotypic identification of human M1 and M2 macrophages, their functional characteristics, and their ability to be reprogrammed given the appropriate stimuli. PMID:25870903

  11. THE DISK EVAPORATION MODEL FOR THE SPECTRAL FEATURES OF LOW-LUMINOSITY ACTIVE GALACTIC NUCLEI

    SciTech Connect

    Qiao, Erlin; Liu, B. F.; Panessa, Francesca; Liu, J. Y.

    2013-11-10

    Observations show that the accretion flows in low-luminosity active galactic nuclei probably have a two-component structure with an inner, hot, optically thin, advection-dominated accretion flow (ADAF) and an outer, truncated, cool, optically thick accretion disk. As shown by Taam et al., the truncation radius as a function of mass accretion rate is strongly affected by including the magnetic field within the framework of disk evaporation model, i.e., an increase in the magnetic field results in a smaller truncation radius of the accretion disk. In this work, we calculate the emergent spectrum of an inner ADAF + an outer truncated accretion disk around a supermassive black hole based on the prediction by Taam et al.. It is found that an increase in the magnetic field from β = 0.8 to β = 0.5 (with magnetic pressure p{sub m} = B {sup 2}/8π = (1 – β)p{sub tot}, p{sub tot} = p{sub gas} + p{sub m}) results in a factor of ∼8.7 increase in the luminosity from the truncated accretion disk. Meanwhile, results of the peak emission of the truncated accretion disk shift toward a a factor of ∼5 higher frequency. We found that the equipartition of gas pressure to magnetic pressure, i.e., β = 0.5, failed to explain the observed anti-correlation between L{sub 2-10{sub keV}}/L{sub Edd} and the bolometric correction κ{sub 2-10{sub keV}} (with κ{sub 2-10{sub keV}} = L{sub bol}/L{sub 2-10{sub keV}}). The emergent spectra for larger values of β = 0.8 or β = 0.95 can explain the observed L{sub 2-10{sub keV}}/L{sub Edd}-κ{sub 2-10{sub keV}} correlation. We argue that in the disk evaporation model, the electrons in the corona are assumed to be heated only by a transfer of energy from the ions to electrons via Coulomb collisions, which is reasonable for accretion with a lower mass accretion rate. Coulomb heating is the dominated heating mechanism for the electrons only if the magnetic field is strongly sub-equipartition, which is roughly consistent with observations.

  12. The Impact of Salient Advertisements on Reading and Attention on Web Pages

    ERIC Educational Resources Information Center

    Simola, Jaana; Kuisma, Jarmo; Oorni, Anssi; Uusitalo, Liisa; Hyona, Jukka

    2011-01-01

    Human vision is sensitive to salient features such as motion. Therefore, animation and onset of advertisements on Websites may attract visual attention and disrupt reading. We conducted three eye tracking experiments with authentic Web pages to assess whether (a) ads are efficiently ignored, (b) ads attract overt visual attention and disrupt…

  13. Insights into Facebook Pages: an early adolescent health research study page targeted at parents.

    PubMed

    Amon, Krestina L; Paxton, Karen; Klineberg, Emily; Riley, Lisa; Hawke, Catherine; Steinbeck, Katharine

    2016-02-01

    Facebook has been used in health research, but there is a lack of literature regarding how Facebook may be used to recruit younger adolescents. A Facebook Page was created for an adolescent cohort study on the effects of puberty hormones on well-being and behaviour in early adolescence. Used as a communication tool with existing participants, it also aimed to alert potential participants to the study. The purpose of this paper is to provide a detailed description of the development of the study Facebook Page and present the fan response to the types of posts made on the Page using the Facebook-generated Insights data. Two types of posts were made on the study Facebook Page. The first type was study-related update posts and events. The second was relevant adolescent and family research and current news posts. Observations on the use of and response to the Page were made over 1 year across three phases (phase 1, very low Facebook use; phase 2, high Facebook use; phase 3, low Facebook use). Most Page fans were female (88.6%), with the largest group of fans aged between 35 and 44 years. Study-related update posts with photographs were the most popular. This paper provides a model on which other researchers could base Facebook communication and potential recruitment in the absence of established guidelines. PMID:25781667

  14. Do not hesitate to use Tversky-and other hints for successful active analogue searches with feature count descriptors.

    PubMed

    Horvath, Dragos; Marcou, Gilles; Varnek, Alexandre

    2013-07-22

    This study is an exhaustive analysis of the neighborhood behavior over a large coherent data set (ChEMBL target/ligand pairs of known Ki, for 165 targets with >50 associated ligands each). It focuses on similarity-based virtual screening (SVS) success defined by the ascertained optimality index. This is a weighted compromise between purity and retrieval rate of active hits in the neighborhood of an active query. One key issue addressed here is the impact of Tversky asymmetric weighing of query vs candidate features (represented as integer-value ISIDA colored fragment/pharmacophore triplet count descriptor vectors). The nearly a 3/4 million independent SVS runs showed that Tversky scores with a strong bias in favor of query-specific features are, by far, the most successful and the least failure-prone out of a set of nine other dissimilarity scores. These include classical Tanimoto, which failed to defend its privileged status in practical SVS applications. Tversky performance is not significantly conditioned by tuning of its bias parameter α. Both initial "guesses" of α = 0.9 and 0.7 were more successful than Tanimoto (at its turn, better than Euclid). Tversky was eventually tested in exhaustive similarity searching within the library of 1.6 M commercial + bioactive molecules at http://infochim.u-strasbg.fr/webserv/VSEngine.html , comparing favorably to Tanimoto in terms of "scaffold hopping" propensity. Therefore, it should be used at least as often as, perhaps in parallel to Tanimoto in SVS. Analysis with respect to query subclasses highlighted relationships of query complexity (simply expressed in terms of pharmacophore pattern counts) and/or target nature vs SVS success likelihood. SVS using more complex queries are more robust with respect to the choice of their operational premises (descriptors, metric). Yet, they are best handled by "pro-query" Tversky scores at α > 0.5. Among simpler queries, one may distinguish between "growable" (allowing for active

  15. Controlling misses and false alarms in a machine learning framework for predicting uniformity of printed pages

    NASA Astrophysics Data System (ADS)

    Nguyen, Minh Q.; Allebach, Jan P.

    2015-01-01

    In our previous work1 , we presented a block-based technique to analyze printed page uniformity both visually and metrically. The features learned from the models were then employed in a Support Vector Machine (SVM) framework to classify the pages into one of the two categories of acceptable and unacceptable quality. In this paper, we introduce a set of tools for machine learning in the assessment of printed page uniformity. This work is primarily targeted to the printing industry, specifically the ubiquitous laser, electrophotographic printer. We use features that are well-correlated with the rankings of expert observers to develop a novel machine learning framework that allows one to achieve the minimum "false alarm" rate, subject to a chosen "miss" rate. Surprisingly, most of the research that has been conducted on machine learning does not consider this framework. During the process of developing a new product, test engineers will print hundreds of test pages, which can be scanned and then analyzed by an autonomous algorithm. Among these pages, most may be of acceptable quality. The objective is to find the ones that are not. These will provide critically important information to systems designers, regarding issues that need to be addressed in improving the printer design. A "miss" is defined to be a page that is not of acceptable quality to an expert observer that the prediction algorithm declares to be a "pass". Misses are a serious problem, since they represent problems that will not be seen by the systems designers. On the other hand, "false alarms" correspond to pages that an expert observer would declare to be of acceptable quality, but which are flagged by the prediction algorithm as "fails". In a typical printer testing and development scenario, such pages would be examined by an expert, and found to be of acceptable quality after all. "False alarm" pages result in extra pages to be examined by expert observers, which increases labor cost. But "false

  16. Clonal B cells in Waldenström's macroglobulinemia exhibit functional features of chronic active B-cell receptor signaling

    PubMed Central

    Argyropoulos, K V; Vogel, R; Ziegler, C; Altan-Bonnet, G; Velardi, E; Calafiore, M; Dogan, A; Arcila, M; Patel, M; Knapp, K; Mallek, C; Hunter, Z R; Treon, S P; van den Brink, M R M; Palomba, M L

    2016-01-01

    Waldenström's macroglobulinemia (WM) is a B-cell non-Hodgkin's lymphoma (B-NHL) characterized by immunoglobulin M (IgM) monoclonal gammopathy and the medullary expansion of clonal lymphoplasmacytic cells. Neoplastic transformation has been partially attributed to hyperactive MYD88 signaling, secondary to the MYD88 L265P mutation, occurring in the majority of WM patients. Nevertheless, the presence of chronic active B-cell receptor (BCR) signaling, a feature of multiple IgM+ B-NHL, remains a subject of speculation in WM. Here, we interrogated the BCR signaling capacity of primary WM cells by utilizing multiparametric phosphoflow cytometry and found heightened basal phosphorylation of BCR-related signaling proteins, and augmented phosphoresponses on surface IgM (sIgM) crosslinking, compared with normal B cells. In support of those findings we observed high sIgM expression and loss of phosphatase activity in WM cells, which could both lead to signaling potentiation in clonal cells. Finally, led by the high-signaling heterogeneity among WM samples, we generated patient-specific phosphosignatures, which subclassified patients into a ‘high' and a ‘healthy-like' signaling group, with the second corresponding to patients with a more indolent clinical phenotype. These findings support the presence of chronic active BCR signaling in WM while providing a link between differential BCR signaling utilization and distinct clinical WM subgroups. PMID:26867669

  17. Prognostic features of signal transducer and activator of transcription 3 in an ER(+) breast cancer model system

    PubMed Central

    Liu, Li-Yu D; Chang, Li-Yun; Kuo, Wen-Hung; Hwa, Hsiao-Lin; Lin, Yi-Shing; Jeng, Meei-Huey; Roth, Don A; Chang, King-Jen; Hsieh, Fon-Jou

    2014-01-01

    The aberrantly expressed signal transducer and activator of transcription 3 (STAT3) predicts poor prognosis, primarily in estrogen receptor positive (ER(+)) breast cancers. Activated STAT3 is overexpressed in luminal A subtype cells. The mechanisms contributing to the prognosis and/or subtype relevant features of STAT3 in ER(+) breast cancers are through multiple interacting regulatory pathways, including STAT3-MYC, STAT3-ERα, and STAT3-MYC-ERα interactions, as well as the direct action of activated STAT3. These data predict malignant events, treatment responses and a novel enhancer of tamoxifen resistance. The inferred crosstalk between ERα and STAT3 in regulating their shared target gene-METAP2 is partially validated in the luminal B breast cancer cell line-MCF7. Taken together, we identify a poor prognosis relevant gene set within the STAT3 network and a robust one in a subset of patients. VEGFA, ABL1, LYN, IGF2R and STAT3 are suggested therapeutic targets for further study based upon the degree of differential expression in our model. PMID:24526833

  18. Structural and conformational features relevant to the anti-tumor activity of calicheamicin γ 1I.

    PubMed

    Ellestad, George A

    2011-09-01

    The structural and conformational features of the potent 10-membered enediyne-containing calicheamicin γ 1I that account for its remarkable DNA site-specific binding and cleavage are reviewed. A variety of spectroscopic and biophysical techniques were used to gain insight into the binding and stereospecific DNA cleavage of this potent antitumor agent. These include gel-shift cleavage assays, atom transfer NMR experiments, drug-DNA conformational studies, circular dichroism, and capillary electrophoresis. Computational descriptions are described for the DNA binding and cleavage of calicheamicin and its activated transient intermediates based on density functional and molecular mechanics calculations. In addition, the structure and clinical utility of calicheamicin immunoconjugates for antibody-targeted chemotherapy is presented. PMID:21800378

  19. Wellness Partners: Design and Evaluation of a Web-Based Physical Activity Diary with Social Gaming Features for Adults

    PubMed Central

    Wang, Hua; Spruijt-Metz, Donna; Jordan-Marsh, Maryalice; Valente, Thomas William

    2013-01-01

    Background The United States is currently in an age of obesity and inactivity despite increasing public awareness and scientific knowledge of detrimental long-term health effects of this lifestyle. Behavior-tracking diaries offer an effective strategy for physical activity adherence and weight management. Furthermore, Web-based physical activity diaries can engage meaningful partners in people’s social networks through fun online gaming interactions and generate motivational mechanisms for effective behavioral change and positive health outcomes. Objective Wellness Partners (WP) is a Web-based intervention in the form of a physical activity diary with social networking and game features. Two versions were designed and developed for the purpose of this study—“Diary” only and “Diary+Game”. The objectives of this study included pilot testing the research process of this intervention design, implementation, evaluation, and exploring the effectiveness of social gaming features on adult participants’ physical activity and anthropometric measures. Methods We conducted a field experiment with randomized crossover design. Assessments occurred at baseline, first follow-up (FU, 5-8 weeks after using one version of WP), and second FU (5-8 weeks of using the other version of WP). In the control condition, participants started with the “Diary” version of WP while in the experimental condition, participants started with the “Diary+Game” version of WP. A total of 54 adults (egos) ages 44-88, and their family and friends (alters) ages 17-69 participated in the study in ego-network groups. Both egos and their alters completed online surveys about their exercise habits. In addition, egos completed anthropometric measurements of BMI, fat percentage, and fat mass by bioimpedance. Results From October 2009 to May 2010, flyers, emails, and Web advertisements yielded 335 volunteers who were screened. Rolling recruitment resulted in enrollment of 142 qualified

  20. DEEP SILICATE ABSORPTION FEATURES IN COMPTON-THICK ACTIVE GALACTIC NUCLEI PREDOMINANTLY ARISE DUE TO DUST IN THE HOST GALAXY

    SciTech Connect

    Goulding, A. D.; Forman, W. R.; Jones, C.; Trichas, M.; Alexander, D. M.; Mullaney, J. R.; Bauer, F. E.; Hickox, R. C.

    2012-08-10

    We explore the origin of mid-infrared (mid-IR) dust extinction in all 20 nearby (z < 0.05) bona fide Compton-thick (N{sub H} > 1.5 Multiplication-Sign 10{sup 24} cm{sup -2}) active galactic nuclei (AGNs) with hard energy (E > 10 keV) X-ray spectral measurements. We accurately measure the silicate absorption features at {lambda} {approx} 9.7 {mu}m in archival low-resolution (R {approx} 57-127) Spitzer Infrared Spectrograph spectroscopy, and show that only a minority ( Almost-Equal-To 45%) of nearby Compton-thick AGNs have strong Si-absorption features (S{sub 9.7} = ln (f{sub int}/f{sub obs}) {approx}> 0.5) which would indicate significant dust attenuation. The majority ( Almost-Equal-To 60%) are star formation dominated (AGN:SB < 0.5) at mid-IR wavelengths and lack the spectral signatures of AGN activity at optical wavelengths, most likely because the AGN emission lines are optically extinguished. Those Compton-thick AGNs hosted in low-inclination-angle galaxies exhibit a narrow range in Si-absorption (S{sub 9.7} {approx} 0-0.3), which is consistent with that predicted by clumpy-torus models. However, on the basis of the IR spectra and additional lines of evidence, we conclude that the dominant contribution to the observed mid-IR dust extinction is dust located in the host galaxy (i.e., due to disturbed morphologies, dust lanes, galaxy inclination angles) and not necessarily a compact obscuring torus surrounding the central engine.

  1. 46. Photograph of a published page. 'OPERATIONS IN INCORPORATION BUILDINGS: ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    46. Photograph of a published page. 'OPERATIONS IN INCORPORATION BUILDINGS: HOLSTON DEFENSE CORPORATION. 'HOLSTON ARMY AMMUNITION PLANT.' Page 17. (no date). - Holston Army Ammunition Plant, RDX-and-Composition-B Manufacturing Line 9, Kingsport, Sullivan County, TN

  2. 45. Photograph of a published page. OPERATIONS IN 'H' OR ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    45. Photograph of a published page. OPERATIONS IN 'H' OR DEWATERING BUILDING: HOLSTON DEFENSE CORPORATION. 'HOLSTON ARMY AMMUNITION PLANT.' Page 16. (no date). - Holston Army Ammunition Plant, RDX-and-Composition-B Manufacturing Line 9, Kingsport, Sullivan County, TN

  3. Emphasizing Social Features in Information Portals: Effects on New Member Engagement.

    PubMed

    Sharma, Nikhil; Butler, Brian S; Irwin, Jeannie; Spallek, Heiko

    2011-11-01

    Many information portals are adding social features with hopes of enhancing the overall user experience. Invitations to join and welcome pages that highlight these social features are expected to encourage use and participation. While this approach is widespread and seems plausible, the effect of providing and highlighting social features remains to be tested. We studied the effects of emphasizing social features on users' response to invitations, their decisions to join, their willingness to provide profile information, and their engagement with the portal's social features. The results of a quasi-experiment found no significant effect of social emphasis in invitations on receivers' responsiveness. However, users receiving invitations highlighting social benefits were less likely to join the portal and provide profile information. Social emphasis in the initial welcome page for the site also was found to have a significant effect on whether individuals joined the portal, how much profile information they provided and shared, and how much they engaged with social features on the site. Unexpectedly, users who were welcomed in a social manner were less likely to join and provided less profile information; they also were less likely to engage with social features of the portal. This suggests that even in online contexts where social activity is an increasingly common feature, highlighting the presence of social features may not always be the optimal presentation strategy. PMID:23626487

  4. Emphasizing Social Features in Information Portals: Effects on New Member Engagement

    PubMed Central

    Sharma, Nikhil; Butler, Brian S.; Irwin, Jeannie; Spallek, Heiko

    2013-01-01

    Many information portals are adding social features with hopes of enhancing the overall user experience. Invitations to join and welcome pages that highlight these social features are expected to encourage use and participation. While this approach is widespread and seems plausible, the effect of providing and highlighting social features remains to be tested. We studied the effects of emphasizing social features on users' response to invitations, their decisions to join, their willingness to provide profile information, and their engagement with the portal's social features. The results of a quasi-experiment found no significant effect of social emphasis in invitations on receivers' responsiveness. However, users receiving invitations highlighting social benefits were less likely to join the portal and provide profile information. Social emphasis in the initial welcome page for the site also was found to have a significant effect on whether individuals joined the portal, how much profile information they provided and shared, and how much they engaged with social features on the site. Unexpectedly, users who were welcomed in a social manner were less likely to join and provided less profile information; they also were less likely to engage with social features of the portal. This suggests that even in online contexts where social activity is an increasingly common feature, highlighting the presence of social features may not always be the optimal presentation strategy. PMID:23626487

  5. 3D SMoSIFT: three-dimensional sparse motion scale invariant feature transform for activity recognition from RGB-D videos

    NASA Astrophysics Data System (ADS)

    Wan, Jun; Ruan, Qiuqi; Li, Wei; An, Gaoyun; Zhao, Ruizhen

    2014-03-01

    Human activity recognition based on RGB-D data has received more attention in recent years. We propose a spatiotemporal feature named three-dimensional (3D) sparse motion scale-invariant feature transform (SIFT) from RGB-D data for activity recognition. First, we build pyramids as scale space for each RGB and depth frame, and then use Shi-Tomasi corner detector and sparse optical flow to quickly detect and track robust keypoints around the motion pattern in the scale space. Subsequently, local patches around keypoints, which are extracted from RGB-D data, are used to build 3D gradient and motion spaces. Then SIFT-like descriptors are calculated on both 3D spaces, respectively. The proposed feature is invariant to scale, transition, and partial occlusions. More importantly, the running time of the proposed feature is fast so that it is well-suited for real-time applications. We have evaluated the proposed feature under a bag of words model on three public RGB-D datasets: one-shot learning Chalearn Gesture Dataset, Cornell Activity Dataset-60, and MSR Daily Activity 3D dataset. Experimental results show that the proposed feature outperforms other spatiotemporal features and are comparative to other state-of-the-art approaches, even though there is only one training sample for each class.

  6. Ultrastructural features of left ventricular myocytes in active and torpid hamsters compared with rats: a morphometric study.

    PubMed Central

    Skepper, J N; Navaratnam, V

    1995-01-01

    Myocytes from the midmyocardium of the left ventricle of rats and hamsters were examined by transmission electron microscopy. The volume fraction of lipid droplets in such myocytes was about 6 times greater in the active hamster than in the rat, but it became progressively reduced during cold exposure and entry into hibernation to values similar to those of the rat. The volume fraction of the T-system as well as the surface density of its membranes were each found to be twice as large in hamster myocytes as in the rat but there was no difference in these parameters between control, cold-exposed and torpid hamsters. The surface density of the junctional sarcoplasmic reticulum coupled with elements of the T-system was greater in active hamsters when compared with those of the rat, and greater still in torpid hamsters. There was no significant difference in the surface density of free sarcoplasmic reticulum between control hamsters, cold-exposed hamsters and rats but it was almost doubled in torpid hamsters. It is proposed that these features represent inherent differences in the ultrastructure of the left ventricle between the rat and hamster that may facilitate entry into hibernation. Additionally, further structural modifications during entry into hibernation may be related to alterations in lipid metabolism and modifications of calcium handling. Images Fig. 1 Fig. 2 PMID:7559131

  7. Canine CD4+CD8+ double positive T cells in peripheral blood have features of activated T cells.

    PubMed

    Bismarck, Doris; Schütze, Nicole; Moore, Peter; Büttner, Mathias; Alber, Gottfried; Buttlar, Heiner v

    2012-10-15

    In dogs a CD4(+)CD8(+) double positive T cell subpopulation exists that has not been phenotypically defined yet. We demonstrate that canine CD4(+)CD8(+) T cells are mature CD1a(-) and TCRαβ(+) T cells. To analyse the activation potential of CD4(+)CD8(+) T cells, PBMC from dogs vaccinated against canine distemper virus (CDV) were re-stimulated with CDV. Upon antigen-specific stimulation, the CD4(+)CD8(+) T cell fraction increases and consists nearly exclusively of proliferated cells. Similarly, other features of activated effector/memory T cells such as up-regulation of CD25 and MHC-II as well as down-regulation of CD62L (L-selectin) were observed in CD4(+)CD8(+) T cells after stimulation. Canine CD4(+)CD8(+) T cells are less abundant, but more heterogeneous than porcine ones, comprising a small proportion expressing the β chain of CD8 in addition to the CD8α chain, like human CD4(+)CD8(+) T cells. In summary, this analysis provides the basis for functional characterisation of the in vivo relevance of CD4(+)CD8(+) T cells in T-cell mediated immunity. PMID:22789871

  8. World Wide Web Pages--Tools for Teaching and Learning.

    ERIC Educational Resources Information Center

    Beasley, Sarah; Kent, Jean

    Created to help educators incorporate World Wide Web pages into teaching and learning, this collection of Web pages presents resources, materials, and techniques for using the Web. The first page focuses on tools for teaching and learning via the Web, providing pointers to sites containing the following: (1) course materials for both distance and…

  9. 47 CFR 22.503 - Paging geographic area authorizations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 2 2013-10-01 2013-10-01 false Paging geographic area authorizations. 22.503 Section 22.503 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES PUBLIC MOBILE SERVICES Paging and Radiotelephone Service § 22.503 Paging geographic area authorizations. The FCC considers applications for...

  10. Young Children's Interpretations of Page Breaks in Contemporary Picture Storybooks

    ERIC Educational Resources Information Center

    Sipe, Lawrence R.; Brightman, Anne E.

    2009-01-01

    This article reports on a study of the responses of a second-grade class to the page breaks in contemporary picturebooks. In a picturebook, the text and accompanying illustrations are divided into a series of facing pages called openings, and the divisions between the openings are called page breaks or turns. Unlike a novel, in which the page…

  11. Required Discussion Web Pages in Psychology Courses and Student Outcomes

    ERIC Educational Resources Information Center

    Pettijohn, Terry F., II; Pettijohn, Terry F.

    2007-01-01

    We conducted 2 studies that investigated student outcomes when using discussion Web pages in psychology classes. In Study 1, we assigned 213 students enrolled in Introduction to Psychology courses to either a mandatory or an optional Web page discussion condition. Students used the discussion Web page significantly more often and performed…

  12. Digital Ethnography: Library Web Page Redesign among Digital Natives

    ERIC Educational Resources Information Center

    Klare, Diane; Hobbs, Kendall

    2011-01-01

    Presented with an opportunity to improve Wesleyan University's dated library home page, a team of librarians employed ethnographic techniques to explore how its users interacted with Wesleyan's current library home page and web pages in general. Based on the data that emerged, a group of library staff and members of the campus' information…

  13. Facebook's personal page modelling and simulation

    NASA Astrophysics Data System (ADS)

    Sarlis, Apostolos S.; Sakas, Damianos P.; Vlachos, D. S.

    2015-02-01

    In this paper we will try to define the utility of Facebook's Personal Page marketing method. This tool that Facebook provides, is modelled and simulated using iThink in the context of a Facebook marketing agency. The paper has leveraged the system's dynamic paradigm to conduct Facebook marketing tools and methods modelling, using iThink™ system to implement them. It uses the design science research methodology for the proof of concept of the models and modelling processes. The following model has been developed for a social media marketing agent/company, Facebook platform oriented and tested in real circumstances. This model is finalized through a number of revisions and iterators of the design, development, simulation, testing and evaluation processes. The validity and usefulness of this Facebook marketing model for the day-to-day decision making are authenticated by the management of the company organization. Facebook's Personal Page method can be adjusted, depending on the situation, in order to maximize the total profit of the company which is to bring new customers, keep the interest of the old customers and deliver traffic to its website.

  14. NRC PAGE. Sequential Analysis Materials Balance

    SciTech Connect

    Picard, R.

    1992-01-13

    NRCPAGE is used in safeguards applications to detect a recurring loss of special nuclear material by frequent evaluation (sequential analysis) of accountability data. Standard sequential testing procedures are traditionally based on sequences of independent and normally distributed measurements. This same approach can be applied to materials balance (MB) data. Here, the term materials balance has a meaning similar to inventory difference and represents a materials loss indicator localized in time and space. However, distinct MBs cannot be reasonably treated as statistically independent and may not always be reasonably treated as normally distributed. Furthermore, the covariance structure associated with a given MB sequence is not known and must be estimated. Nonindependence is treated by converting the MB sequence to the innovation sequence, sometimes called the ITMUF sequence or the sequence of MUF residuals, which are statistically independent and amenable to sequential test procedures. A one-sided page`s test, effective for a wide range of recurring loss scenarios, is applied to the standardized innovation sequence. The program can be easily modified to suit particular needs; the models for the assumption of multivariate normality for MBs when computing the innovation sequence or the test procedure can be changed as can the input/output format, dimensioning, local error checking, and simulation work. Input files can be sequentially constructed using local text editors to update existing files. Output files can be read by graphics, report writer, or other stand-alone utility routines.

  15. Women's Pages or People's Pages: The Production of News for Women in the "Washington Post" in the 1950s.

    ERIC Educational Resources Information Center

    Yang, Mei-ling

    1996-01-01

    Examines the women's pages of the "Washington Post" in the 1950s that were edited by Marie Sauer. States that the newspaper turned down Sauer's request in 1952 to change from traditional women's pages to a unisex "lifestyle" section. Analyzes how women's pages were shaped by factors such as advertising, professional values, and gender beliefs. (PA)

  16. Readers, Authors, and Page Structure: A Discussion of Four Questions Arising from a Content Analysis of Web Pages.

    ERIC Educational Resources Information Center

    Haas, Stephanie W.; Grams, Erika S.

    2000-01-01

    Discusses research describing Web page and link classification systems resulting from a content analysis of over 75 Web pages. Topics include the decision-making processes of Web page authors and readers; syntactic analysis of labeled and isolated anchors; expansion and resource links; and where links lead. (Author/LRW)

  17. Neighbourhoods for Active Kids: study protocol for a cross-sectional examination of neighbourhood features and children's physical activity, active travel, independent mobility and body size

    PubMed Central

    Oliver, Melody; McPhee, Julia; Carroll, Penelope; Ikeda, Erika; Mavoa, Suzanne; Mackay, Lisa; Kearns, Robin A; Kyttä, Marketta; Asiasiga, Lanuola; Garrett, Nicholas; Lin, Judy; Mackett, Roger; Zinn, Caryn; Moewaka Barnes, Helen; Egli, Victoria; Prendergast, Kate; Witten, Karen

    2016-01-01

    Introduction New Zealand children's physical activity, including independent mobility and active travel, has declined markedly over recent decades. The Neighbourhoods for Active Kids (NfAK) study examines how neighbourhood built environments are associated with the independent mobility, active travel, physical activity and neighbourhood experiences of children aged 9–12 years in primary and intermediate schools across Auckland, New Zealand's largest city. Methods and analysis Child-specific indices of walkability, destination accessibility and traffic exposure will be constructed to measure the built environment in 8 neighbourhoods in Auckland. Interactive online-mapping software will be used to measure children's independent mobility and transport mode to destinations and to derive measures of neighbourhood use and perceptions. Physical activity will be measured using 7-day accelerometry. Height, weight and waist circumference will be objectively measured. Parent telephone interviews will collect sociodemographic information and parent neighbourhood perceptions. Interviews with school representative will capture supports and barriers for healthy activity and nutrition behaviours at the school level. Multilevel modelling approaches will be used to understand how differing built environment variables are associated with activity, neighbourhood experiences and health outcomes. Discussion We anticipate that children who reside in neighbourhoods considered highly walkable will be more physically active, accumulate more independent mobility and active travel, and be more likely to have a healthy body size. This research is timely as cities throughout New Zealand develop and implement plans to improve the liveability of intensifying urban neighbourhoods. Results will be disseminated to participants, local government agencies and through conventional academic avenues. PMID:27531740

  18. Distinct perinatal features of the hyperpolarization-activated non-selective cation current Ih in the rat cortical plate

    PubMed Central

    2012-01-01

    Background During neocortical development, multiple voltage- and ligand-gated ion channels are differentially expressed in neurons thereby shaping their intrinsic electrical properties. One of these voltage-gated ion channels, the hyperpolarization-activated cyclic nucleotide-gated (HCN) channel and its current Ih, is an important regulator of neuronal excitability. Thus far, studies on an early Ih appearance in rodent neocortex are missing or conflicting. Therefore, we focused our study on perinatal neocortical Ih and its properties. Results In the perinatal rat neocortex we observed a rapid increase in the number of neurons exhibiting Ih. Perinatal Ih had unique properties: first, a pronounced cAMP sensitivity resulting in a marked shift of the voltage sufficient for half-maximum activation of the current towards depolarized voltages and second, an up to 10 times slower deactivation at physiological membrane potentials when compared to the one at postnatal day 30. The combination of these features was sufficient to suppress membrane resonance in our in silico and in vitro experiments. Although all four HCN subunits were present on the mRNA level we only detected HCN4, HCN3 and HCN1 on the protein level at P0. HCN1 protein at P0, however, appeared incompletely processed. At P30 glycosilated HCN1 and HCN2 dominated. By in silico simulations and heterologous co-expression experiments of a ‘slow’ and a ‘fast’ Ih conducting HCN channel subunit in HEK293 cells, we mimicked most characteristics of the native current, pointing to a functional combination of subunit homo- or heteromeres. Conclusion Taken together, these data indicate a HCN subunit shift initiated in the first 24 hours after birth and implicate a prominent perinatal role of the phylogenetically older HCN3 and/or HCN4 subunits in the developing neocortex. PMID:22694806

  19. Predicting Pathological Features at Radical Prostatectomy in Patients with Prostate Cancer Eligible for Active Surveillance by Multiparametric Magnetic Resonance Imaging

    PubMed Central

    de Cobelli, Ottavio; Terracciano, Daniela; Tagliabue, Elena; Raimondi, Sara; Bottero, Danilo; Cioffi, Antonio; Jereczek-Fossa, Barbara; Petralia, Giuseppe; Cordima, Giovanni; Almeida, Gilberto Laurino; Lucarelli, Giuseppe; Buonerba, Carlo; Matei, Deliu Victor; Renne, Giuseppe; Di Lorenzo, Giuseppe; Ferro, Matteo

    2015-01-01

    Purpose The aim of this study was to investigate the prognostic performance of multiparametric magnetic resonance imaging (mpMRI) and Prostate Imaging Reporting and Data System (PIRADS) score in predicting pathologic features in a cohort of patients eligible for active surveillance who underwent radical prostatectomy. Methods A total of 223 patients who fulfilled the criteria for “Prostate Cancer Research International: Active Surveillance”, were included. Mp–1.5 Tesla MRI examination staging with endorectal coil was performed at least 6–8 weeks after TRUS-guided biopsy. In all patients, the likelihood of the presence of cancer was assigned using PIRADS score between 1 and 5. Outcomes of interest were: Gleason score upgrading, extra capsular extension (ECE), unfavorable prognosis (occurrence of both upgrading and ECE), large tumor volume (≥0.5ml), and seminal vesicle invasion (SVI). Receiver Operating Characteristic (ROC) curves and Decision Curve Analyses (DCA) were performed for models with and without inclusion of PIRADS score. Results Multivariate analysis demonstrated the association of PIRADS score with upgrading (P<0.0001), ECE (P<0.0001), unfavorable prognosis (P<0.0001), and large tumor volume (P = 0.002). ROC curves and DCA showed that models including PIRADS score resulted in greater net benefit for almost all the outcomes of interest, with the only exception of SVI. Conclusions mpMRI and PIRADS scoring are feasible tools in clinical setting and could be used as decision-support systems for a more accurate selection of patients eligible for AS. PMID:26444548

  20. Synthesis of the quaternary in the almeria littoral neotectonic activity and its morphologic features, western betics, Spain

    NASA Astrophysics Data System (ADS)

    Goy, J. L.; Zazo, C.

    1986-11-01

    A sequence of marine and continental Quaternary episodes is established, as are their interrelationships. The zone's tectonics have, in most cases, remained active to the present and control the factors All the Tyrrhenian levels containing Strombus bubonius are affected by the many faults that cross the lateral fringe and continue onto the shelf. Among these are: the Loma del Viento Fault, (N120°E. a normal fault with certain leftward characteristics): the El Alquian faults (N140°, 160°E, which coincide, according to several authors (Bousquet, 1979), with the surface feature of a great dextral deep accident); and the Carboneras Fault, or the Serrata Fault, (N40°, 45°E, left strike-slip fault). Given the varying behaviour of the shoreline, we have chosen to divide it into four sectors: Campo de Dalias, El-Alquian-Cabo de Gata, Mojacar—Garrucha. and Campo de Nijar-Serrata. Due to its geographical location, no marine-continental relationships exist in the latter. A chart has been made in an attempt to synthesize the most significant stratigraphic, genetic and tectonic characteristics of each sector. Lastly, the influence of tectonics on the distribution and heights of the Quaternary shorelines is clearly shown in a chart of the transgressive maxima of the Tyrrhenian episodes.

  1. Evaluation of image features and search strategies for segmentation of bone structures in radiographs using Active Shape Models.

    PubMed

    Behiels, Gert; Maes, Frederik; Vandermeulen, Dirk; Suetens, Paul

    2002-03-01

    In this paper, we evaluate various image features and different search strategies for fitting Active Shape Models (ASM) to bone object boundaries in digitized radiographs. The original ASM method iteratively refines the pose and shape parameters of the point distribution model driving the ASM by a least squares fit of the shape to update the target points at the estimated object boundary position, as determined by a suitable object boundary criterion. We propose an improved search procedure that is more robust against outlier configurations in the boundary target points by requiring subsequent shape changes to be smooth, which is imposed by a smoothness constraint on the displacement of neighbouring target points at each iteration and implemented by a minimal cost path approach. We compare the original ASM search method and our improved search algorithm with a third method that does not rely on iteratively refined target point positions, but instead optimizes a global Bayesian objective function derived from statistical a priori contour shape and image models. Extensive validation of these methods on a database containing more than 400 images of the femur, humerus and calcaneus using the manual expert segmentation as ground truth shows that our minimal cost path method is the most robust. We also evaluate various measures for capturing local image appearance around each boundary point and conclude that the Mahalanobis distance applied to normalized image intensity profiles extracted normal to the shape is the most suitable criterion among the tested ones for guiding the ASM optimization. PMID:11836134

  2. Relating Field Observed Changes in the Active Stream Channel Network to Features of dQ/dt-Q Recession Curves

    NASA Astrophysics Data System (ADS)

    Shaw, S. B.

    2013-12-01

    Hydrologists have long plotted the rate of recession (dQ/dt) versus the absolute discharge (Q) to infer aquifer hydraulic properties. In recent years, these dQ/dt-Q plots have been examined in new ways, in particular, looking at individual event curves within the full dQ/dt-Q plot. When examining individual curves (in log-log space), in many cases one observes relatively constant slopes (usually near two) but finds that intercept values shift seasonally. Some have hypothesized that these two features of the dQ/dt-Q plots can be explained by the nature of the contraction of the stream channel network as flow diminishes (e.g. Biswal and Marani, 2010, GRL). To investigate this hypothesis, I have been mapping changes in the active channel network in a 250 ha catchment nested within the larger 69,000 ha Six Mile Creek watershed in central NY. Direct observations of the active channel network have been supplemented with streamflow measurements at 1st and 2nd order channels and the main channel. The larger Six Mile Creek watershed exhibits the expected constant dQ/dt-Q slopes and varying intercepts. However, the 250 ha catchment (assumed to be representative of the upland areas in the larger watershed) maintains a relatively constant active channel network, even during dry periods, and exhibits no systematic contraction of channel lengths. Most 1st order channels appear to be at least in part spring fed from their upper most point of origin. These field observations suggest that at least in this basin, the slope of two in log(dQ/dt) vs log(Q) plots is not directly related to contraction of the channel network. The fractional contribution of subbasins to total basin flow does indicate that these small upland basins contribute a decreased portion of total watershed flow during drier periods, supporting the notion that shifts in intercept may occur because of spatial changes in dominant contributing zones.

  3. Model of Reentrant Ventricular Tachycardia based upon Infarct Border Zone Geometry Predicts Reentrant Circuit Features as Determined by Activation Mapping

    PubMed Central

    Ciaccio, Edward J; Ashikaga, Hiroshi; Kaba, Riyaz A; Cervantes, Daniel; Hopenfeld, Bruce; Wit, Andrew L; Peters, Nicholas S; McVeigh, Elliot R; Garan, Hasan; Coromilas, James

    2008-01-01

    Background Infarct border zone (IBZ) geometry likely affects inducibility and characteristics of postinfarction reentrant ventricular tachycardia, but the connection has not been established. Objective To determine characteristics of post infarction ventricular tachycardia in the IBZ. Methods A geometric model describing the relationship between IBZ geometry and wavefront propagation in reentrant circuits was developed. Based on the formulation, slow conduction and block was expected to coincide with areas where IBZ thickness (T) is minimal and the local spatial gradient in thickness (ΔT) is maximal, so that the degree of wavefront curvature ρ ∝ ΔT/T is maximal. Regions of fastest conduction velocity were predicted to coincide with areas of minimum ΔT. In seven arrhythmogenic postinfarction canine heart experiments, tachycardia was induced by programmed stimulation, and activation maps were constructed from multichannel recordings. IBZ thickness was measured in excised hearts from histologic analysis or magnetic resonance imaging. Reentrant circuit properties were predicted from IBZ geometry and compared with ventricular activation maps following tachycardia induction. Results Mean IBZ thickness was 231±140µm at the reentry isthmus and 1440±770µm in the outer pathway (p<0.001). Mean curvature ρ was 1.63±0.45mm−1 at functional block line locations, 0.71±0.18mm−1 at isthmus entrance-exit points, and 0.33±0.13mm−1 in the outer reentrant circuit pathway. The mean conduction velocity about the circuit during reentrant tachycardia was 0.32±0.04mm/ms at entrance-exit points, 0.42±0.13mm/ms for the entire outer pathway, and 0.64±0.16mm/ms at outer pathway regions with minimum ΔT. Model sensitivity and specificity to detect isthmus location was 75.0±5.7% and 97.2±0.7%. Conclusions Reentrant circuit features as determined by activation mapping can be predicted on the basis of IBZ geometrical relationships. PMID:17675078

  4. Large fontanelles are a shared feature of haploinsufficiency of RUNX2 and its co-activator CBFB.

    PubMed

    Goto, Tomohide; Aramaki, Michihiko; Yoshihashi, Hiroshi; Nishimura, Gen; Hasegawa, Yukihiro; Takahashi, Takao; Ishii, Takashi; Fukushima, Yoshimitsu; Kosaki, Kenjiro

    2004-12-01

    CBFB at 16q22 heterodimerizes with either RUNX2 (also known as CBFA1) or RUNX1 (CBFA2) to activate the transcription of downstream molecules. RUNX2 regulates osteoblast differentiation and chondrocyte maturation and its haploinsufficiency leads to cleidocranial dysplasia, characterized large fontanelles, hypoplasia or aplasia of the clavicles, hypoplasia of the distal phalanges, and a wide pubic symphysis. Complete loss of Runx1 or Cbfb in mice is lethal because of the absence of fetal liver hematopoiesis. Fetal rescue in Cbfb(-/-) mice by providing the Cbfb functions in the hematopoietic progenitors leads to wide fontanelle and delayed chondrocyte maturation, presumably resulting from the incomplete function of the transcriptional pathway mediated by the Cbfb-Runx2 heterodimer. The present report describes a patient with a small deletion of chromosome 16q22.1 encompassing CBFB. Skeletal abnormalities included a widely open fontanelle, multiple wormian bones along the sagittal suture, hypoplasia of the distal phalanges, and mildly shortened clavicles. G-banding analysis revealed a shortening of the 16q22.1 band. A fluorescence in situ hybridization analysis, using the BAC probe spanning the CBFB locus at 16q22.1, revealed that the CBFB probe hybridized to only one of the two homologous chromosome 16 regions. Array-comparative genomic hybridization analysis revealed that the deletion spans 1.2 megabases. In reviewing eight previously reported cases of 16q interstitial deletions involving band q22, large cranial sutures were noted in all but one case. Considering the phenotypic similarity of the 16q22 deletion case and Cbfb(-/-) mice rescued for hematopoiesis and the consistency of the phenotype among 16q22 deletion cases, we suggest that the common phenotypic feature of the 16q22 deletion, large fontanelles, can be attributed to a haploinsufficiency of CBFB. PMID:15566413

  5. Active Features of Guguan-Guizhen Fault at the Northeast Margin of Qinghai-Tibet Block since Late Quaternary

    NASA Astrophysics Data System (ADS)

    Shi, Yaqin; Feng, Xijie; Li, Gaoyang; Ma, Ji; Li, Miao; Zhang, Yi

    2015-04-01

    Guguan-Guizhen fault is located at the northeast margin of Qinghai-Tibet Block and northwest margin of Ordos Block; it is the boundary of the two blocks, and one of the multiple faults of northwest Haiyuan-Liupanshan-Baoji fault zone. Guguan-Guizhen fault starts from Putuo Village, Huating County, Gansu Province, and goes through Badu Town, Long County in Shaanxi Province ends in Guozhen Town in Baoji City, Shaanxi Province. The fault has a full length of about 130km with the strike of 310-330°, the dip of SW and the rake of 50-60°, which is a sinistral slip reverse fault in the north part, and a sinistral slip normal fault in the southeast part. Guguan-Guizhen fault has a clear liner structure in satellite images and significant landform elevation difference with a maximum difference of 80m, and is higher in the east lower in the west. The northwest side of Guguan-Guizhen fault is composed of purplish-red Lower Cretaceous sandstones and river terrace; the northeast side is composed of Ordovician Limestone. Shigou, Piliang, Songjiashan, Tianjiagou and Chenjiagou fault profiles are found to the south of Badu Village. After 14C and optically stimulated luminescence dating, the fault does not dislocate the stratum since late Pleistocene (90.5±4.4ka) in Shigou, Piliang and Songjiashan fault profiles, and does not dislocate the cobble layer of Holocene first terrace and recent sliderock (3180±30 BP). But the fault dislocated the stratum of middle Pleistocene in some of the fault profiles. All the evidences above indicate that the fault is active in middle Pleistocene, and being silence since late Pleistocene. It might be active in Holocene to the north of Badu Village due to collapses are found in a certain area. The cause of these collapses is Qinlong M6-7 earthquake in 600 A.D., and might be relevant with Guguan-Guizhen fault after analysis of the scale, feature and age determination of the collapse. If any seismic surface rupture and ancient earthquake traces

  6. Calibrating page sized Gafchromic EBT3 films

    SciTech Connect

    Crijns, W.; Maes, F.; Heide, U. A. van der; Van den Heuvel, F.

    2013-01-15

    Purpose: The purpose is the development of a novel calibration method for dosimetry with Gafchromic EBT3 films. The method should be applicable for pretreatment verification of volumetric modulated arc, and intensity modulated radiotherapy. Because the exposed area on film can be large for such treatments, lateral scan errors must be taken into account. The correction for the lateral scan effect is obtained from the calibration data itself. Methods: In this work, the film measurements were modeled using their relative scan values (Transmittance, T). Inside the transmittance domain a linear combination and a parabolic lateral scan correction described the observed transmittance values. The linear combination model, combined a monomer transmittance state (T{sub 0}) and a polymer transmittance state (T{sub {infinity}}) of the film. The dose domain was associated with the observed effects in the transmittance domain through a rational calibration function. On the calibration film only simple static fields were applied and page sized films were used for calibration and measurements (treatment verification). Four different calibration setups were considered and compared with respect to dose estimation accuracy. The first (I) used a calibration table from 32 regions of interest (ROIs) spread on 4 calibration films, the second (II) used 16 ROIs spread on 2 calibration films, the third (III), and fourth (IV) used 8 ROIs spread on a single calibration film. The calibration tables of the setups I, II, and IV contained eight dose levels delivered to different positions on the films, while for setup III only four dose levels were applied. Validation was performed by irradiating film strips with known doses at two different time points over the course of a week. Accuracy of the dose response and the lateral effect correction was estimated using the dose difference and the root mean squared error (RMSE), respectively. Results: A calibration based on two films was the optimal

  7. College of DuPage Information Technology Plan, Fiscal Year 1994-95.

    ERIC Educational Resources Information Center

    College of DuPage, Glen Ellyn, IL.

    Building upon four previous planning documents for computing at College of DuPage in Illinois, this plan for fiscal year 1995 (FY95) provides a starting point for future plans to address all activities that relate to the use of information technology on campus. The FY95 "Information Technology Plan" is divided into six sections, each providing an…

  8. New Cloud Activity on Uranus in 2004: First Detection of a Southern Feature at 2.2 microns

    SciTech Connect

    Hammel, H B; de Pater, I; Gibbard, S; Lockwood, G; Rages, K

    2005-02-02

    On 4 July 2004 UT, we detected one of Uranus' southern hemispheric features at K' (2.2 {micro}m); this is the first such detection in half a decade of adaptive optics imaging of Uranus at the Keck 10-m telescope. When we observed again on 8 July UT the core had faded, and by 9 July UT it was not seen at K' and barely detectable at H. The detection and subsequent disappearance of the feature indicates rapid dynamical processes in the localized vertical aerosol structure.

  9. Web Pages for Your Classroom: The Easy Way!

    ERIC Educational Resources Information Center

    McCorkle, Sandra K.

    This book provides the classroom teacher or librarian with templates and instructions for creating Web pages for use with middle school or high school students. The pages can then be used for doing research projects or other types of projects that familiarize students with the power, flexibility, and usefulness of the Web. Part I, Technology in…

  10. 47 CFR 95.27 - Paging receiver description.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Paging receiver description. 95.27 Section 95.27 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES PERSONAL RADIO SERVICES General Mobile Radio Service (GMRS) § 95.27 Paging receiver description. A...

  11. 47 CFR 95.27 - Paging receiver description.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Paging receiver description. 95.27 Section 95.27 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES PERSONAL RADIO SERVICES General Mobile Radio Service (GMRS) § 95.27 Paging receiver description. A...

  12. Paging and Scrolling: Cognitive Styles in Learning from Hypermedia

    ERIC Educational Resources Information Center

    Eyuboglu, Filiz; Orhan, Feza

    2011-01-01

    This study investigates the navigational patterns and learning achievement of university students with different cognitive styles, on hypermedia learning environments using paging or scrolling. The global-local subscales of Sternberg's Thinking Styles Inventory, two hypermedia, one using paging, the other using scrolling, a multiple choice…

  13. The Library as Information Provider: The Home Page.

    ERIC Educational Resources Information Center

    Clyde, Laurel A.

    1996-01-01

    Discusses ways in which libraries are using the World Wide Web to provide information via a home page, based on information from a survey in Iceland as well as a larger study that conducted content analyses of home pages of public and school libraries in 13 countries. (Author/LRW)

  14. JavaScript: Convenient Interactivity for the Class Web Page.

    ERIC Educational Resources Information Center

    Gray, Patricia

    This paper shows how JavaScript can be used within HTML pages to add interactive review sessions and quizzes incorporating graphics and sound files. JavaScript has the advantage of providing basic interactive functions without the use of separate software applications and players. Because it can be part of a standard HTML page, it is…

  15. Instructional Opportunities of a Subject-Oriented (Law) Web Page.

    ERIC Educational Resources Information Center

    Lehner, John A.; Jacobson, Trudi E.

    1997-01-01

    Describes the State University of New York at Albany law Web page that was designed to help teach students and others, as well as to provide access to selected law resources. Benefits of this instructional subject-specific Web page are its user-friendliness, its flexibility, its ability to provide a cognitive structure and to promote critical…

  16. Evaluating Information Quality: Hidden Biases on the Children's Web Pages

    ERIC Educational Resources Information Center

    Kurubacak, Gulsun

    2006-01-01

    As global digital communication continues to flourish, the Children's Web pages become more critical for children to realize not only the surface but also breadth and deeper meanings in presenting these milieus. These pages not only are very diverse and complex but also enable intense communication across social, cultural and political…

  17. Dynamic Web Pages: Performance Impact on Web Servers.

    ERIC Educational Resources Information Center

    Kothari, Bhupesh; Claypool, Mark

    2001-01-01

    Discussion of Web servers and requests for dynamic pages focuses on experimentally measuring and analyzing the performance of the three dynamic Web page generation technologies: CGI, FastCGI, and Servlets. Develops a multivariate linear regression model and predicts Web server performance under some typical dynamic requests. (Author/LRW)

  18. Toward a User-Centered Academic Library Home Page

    ERIC Educational Resources Information Center

    McHale, Nina

    2008-01-01

    In the past decade, academic libraries have struggled with the design of an effective library home page. Since librarians' mental models of information architecture differ from those of their patrons, usability assessments are necessary in designing a user-centered home page. This study details a usability sequence of card sort and paper and…

  19. Adobe InDesign vs. QuarkXPress and PageMaker: The Best of Both Worlds?

    ERIC Educational Resources Information Center

    Wilson, Bradley

    2000-01-01

    Evaluates the newly released Adobe InDesign software, finding that while it brings new life into desktop publishing, it is not yet a "must buy" for publications advisers. Compares specific features that are relevant for student publications, including: character, paragraph, drop caps, define styles, page setup, text wrap, defining and using…

  20. Judging a Book by Its Cover: An Investigation of Peritextual Features in Caldecott Award Books

    ERIC Educational Resources Information Center

    Martinez, Miriam; Stier, Catherine; Falcon, Lori

    2016-01-01

    While scholars have recognized the meaning making potential offered by the peritext of picturebooks, there has previously been only limited research on the nature of peritextual features. This content analysis focused on the ways in which various peritextual features (dust jackets, beginning endpapers, illustrations before title page, title pages,…

  1. Optimizing TLB entries for mixed page size storage in contiguous memory

    DOEpatents

    Chen, Dong; Gara, Alan; Giampapa, Mark E.; Heidelberger, Philip; Kriegel, Jon K.; Ohmacht, Martin; Steinmacher-Burow, Burkhard

    2013-04-30

    A system and method for accessing memory are provided. The system comprises a lookup buffer for storing one or more page table entries, wherein each of the one or more page table entries comprises at least a virtual page number and a physical page number; a logic circuit for receiving a virtual address from said processor, said logic circuit for matching the virtual address to the virtual page number in one of the page table entries to select the physical page number in the same page table entry, said page table entry having one or more bits set to exclude a memory range from a page.

  2. Geographically Modified PageRank Algorithms: Identifying the Spatial Concentration of Human Movement in a Geospatial Network.

    PubMed

    Chin, Wei-Chien-Benny; Wen, Tzai-Hung

    2015-01-01

    A network approach, which simplifies geographic settings as a form of nodes and links, emphasizes the connectivity and relationships of spatial features. Topological networks of spatial features are used to explore geographical connectivity and structures. The PageRank algorithm, a network metric, is often used to help identify important locations where people or automobiles concentrate in the geographical literature. However, geographic considerations, including proximity and location attractiveness, are ignored in most network metrics. The objective of the present study is to propose two geographically modified PageRank algorithms-Distance-Decay PageRank (DDPR) and Geographical PageRank (GPR)-that incorporate geographic considerations into PageRank algorithms to identify the spatial concentration of human movement in a geospatial network. Our findings indicate that in both intercity and within-city settings the proposed algorithms more effectively capture the spatial locations where people reside than traditional commonly-used network metrics. In comparing location attractiveness and distance decay, we conclude that the concentration of human movement is largely determined by the distance decay. This implies that geographic proximity remains a key factor in human mobility. PMID:26437000

  3. Geographically Modified PageRank Algorithms: Identifying the Spatial Concentration of Human Movement in a Geospatial Network

    PubMed Central

    2015-01-01

    A network approach, which simplifies geographic settings as a form of nodes and links, emphasizes the connectivity and relationships of spatial features. Topological networks of spatial features are used to explore geographical connectivity and structures. The PageRank algorithm, a network metric, is often used to help identify important locations where people or automobiles concentrate in the geographical literature. However, geographic considerations, including proximity and location attractiveness, are ignored in most network metrics. The objective of the present study is to propose two geographically modified PageRank algorithms—Distance-Decay PageRank (DDPR) and Geographical PageRank (GPR)—that incorporate geographic considerations into PageRank algorithms to identify the spatial concentration of human movement in a geospatial network. Our findings indicate that in both intercity and within-city settings the proposed algorithms more effectively capture the spatial locations where people reside than traditional commonly-used network metrics. In comparing location attractiveness and distance decay, we conclude that the concentration of human movement is largely determined by the distance decay. This implies that geographic proximity remains a key factor in human mobility. PMID:26437000

  4. An Approach to Extract Informative Rules for Web Page Recommendation by Genetic Programming

    NASA Astrophysics Data System (ADS)

    Kim, Jaekwang; Yoon, Kwangho; Lee, Jee-Hyong

    Clickstreams in users' navigation logs have various data which are related to users' web surfing. Those are visit counts, stay times, product types, etc. When we observe these data, we can divide clickstreams into sub-clickstreams so that the pages in a sub-clickstream share more contexts with each other than with the pages in other sub-clickstreams. In this paper, we propose a method which extracts more informative rules from clickstreams for web page recommendation based on genetic programming and association rules. First, we split clickstreams into sub-clickstreams by contexts for generating more informative rules. In order to split clickstreams in consideration of context, we extract six features from users' navigation logs. A set of split rules is generated by combining those features through genetic programming, and then informative rules for recommendation are extracted with the association rule mining algorithm. Through experiments, we verify that the proposed method is more effective than the other methods in various conditions.

  5. Time-Frequency Feature Representation Using Multi-Resolution Texture Analysis and Acoustic Activity Detector for Real-Life Speech Emotion Recognition

    PubMed Central

    Wang, Kun-Ching

    2015-01-01

    The classification of emotional speech is mostly considered in speech-related research on human-computer interaction (HCI). In this paper, the purpose is to present a novel feature extraction based on multi-resolutions texture image information (MRTII). The MRTII feature set is derived from multi-resolution texture analysis for characterization and classification of different emotions in a speech signal. The motivation is that we have to consider emotions have different intensity values in different frequency bands. In terms of human visual perceptual, the texture property on multi-resolution of emotional speech spectrogram should be a good feature set for emotion classification in speech. Furthermore, the multi-resolution analysis on texture can give a clearer discrimination between each emotion than uniform-resolution analysis on texture. In order to provide high accuracy of emotional discrimination especially in real-life, an acoustic activity detection (AAD) algorithm must be applied into the MRTII-based feature extraction. Considering the presence of many blended emotions in real life, in this paper make use of two corpora of naturally-occurring dialogs recorded in real-life call centers. Compared with the traditional Mel-scale Frequency Cepstral Coefficients (MFCC) and the state-of-the-art features, the MRTII features also can improve the correct classification rates of proposed systems among different language databases. Experimental results show that the proposed MRTII-based feature information inspired by human visual perception of the spectrogram image can provide significant classification for real-life emotional recognition in speech. PMID:25594590

  6. Real-time evaluation of polyphenol oxidase (PPO) activity in lychee pericarp based on weighted combination of spectral data and image features as determined by fuzzy neural network.

    PubMed

    Yang, Yi-Chao; Sun, Da-Wen; Wang, Nan-Nan; Xie, Anguo

    2015-07-01

    A novel method of using hyperspectral imaging technique with the weighted combination of spectral data and image features by fuzzy neural network (FNN) was proposed for real-time prediction of polyphenol oxidase (PPO) activity in lychee pericarp. Lychee images were obtained by a hyperspectral reflectance imaging system operating in the range of 400-1000nm. A support vector machine-recursive feature elimination (SVM-RFE) algorithm was applied to eliminating variables with no or little information for the prediction from all bands, resulting in a reduced set of optimal wavelengths. Spectral information at the optimal wavelengths and image color features were then used respectively to develop calibration models for the prediction of PPO in pericarp during storage, and the results of two models were compared. In order to improve the prediction accuracy, a decision strategy was developed based on weighted combination of spectral data and image features, in which the weights were determined by FNN for a better estimation of PPO activity. The results showed that the combined decision model was the best among all of the calibration models, with high R(2) values of 0.9117 and 0.9072 and low RMSEs of 0.45% and 0.459% for calibration and prediction, respectively. These results demonstrate that the proposed weighted combined decision method has great potential for improving model performance. The proposed technique could be used for a better prediction of other internal and external quality attributes of fruits. PMID:25882427

  7. Stimulus-Related Independent Component and Voxel-Wise Analysis of Human Brain Activity during Free Viewing of a Feature Film

    PubMed Central

    Lahnakoski, Juha M.; Salmi, Juha; Jääskeläinen, Iiro P.; Lampinen, Jouko; Glerean, Enrico; Tikka, Pia; Sams, Mikko

    2012-01-01

    Understanding how the brain processes stimuli in a rich natural environment is a fundamental goal of neuroscience. Here, we showed a feature film to 10 healthy volunteers during functional magnetic resonance imaging (fMRI) of hemodynamic brain activity. We then annotated auditory and visual features of the motion picture to inform analysis of the hemodynamic data. The annotations were fitted to both voxel-wise data and brain network time courses extracted by independent component analysis (ICA). Auditory annotations correlated with two independent components (IC) disclosing two functional networks, one responding to variety of auditory stimulation and another responding preferentially to speech but parts of the network also responding to non-verbal communication. Visual feature annotations correlated with four ICs delineating visual areas according to their sensitivity to different visual stimulus features. In comparison, a separate voxel-wise general linear model based analysis disclosed brain areas preferentially responding to sound energy, speech, music, visual contrast edges, body motion and hand motion which largely overlapped the results revealed by ICA. Differences between the results of IC- and voxel-based analyses demonstrate that thorough analysis of voxel time courses is important for understanding the activity of specific sub-areas of the functional networks, while ICA is a valuable tool for revealing novel information about functional connectivity which need not be explained by the predefined model. Our results encourage the use of naturalistic stimuli and tasks in cognitive neuroimaging to study how the brain processes stimuli in rich natural environments. PMID:22496909

  8. Theoretical bases of radar (selected pages)

    NASA Astrophysics Data System (ADS)

    Shirman, Ya. D.; Golikov, V. N.; Busygin, I. N.; Kostin, G. A.; Manshos, V. N.

    1987-06-01

    A textbook is presented for radio engineering departments of schools of higher education, which prepare specialists in radar. The use of statistical methods of analysis as the single base is it special feature. The principles are given of construction and the theory of the devices/equipment of optimum detection in the presence of interferences; the methods are examined for obtaining the radar information taking into account achievements in the region of the optimum working/treatment of serrated radar signals, laws governing secondary radiation and radiowave propagation. A large number of examples, which permits the reader to more rapidly master main questions of theory and its application, are given.

  9. One-Shot Decoupling and Page Curves from a Dynamical Model for Black Hole Evaporation.

    PubMed

    Brádler, Kamil; Adami, Christoph

    2016-03-11

    One-shot decoupling is a powerful primitive in quantum information theory and was hypothesized to play a role in the black hole information paradox. We study black hole dynamics modeled by a trilinear Hamiltonian whose semiclassical limit gives rise to Hawking radiation. An explicit numerical calculation of the discretized path integral of the S matrix shows that decoupling is exact in the continuous limit, implying that quantum information is perfectly transferred from the black hole to radiation. A striking consequence of decoupling is the emergence of an output radiation entropy profile that follows Page's prediction. We argue that information transfer and the emergence of Page curves is a robust feature of any multilinear interaction Hamiltonian with a bounded spectrum. PMID:27015471

  10. One-Shot Decoupling and Page Curves from a Dynamical Model for Black Hole Evaporation

    NASA Astrophysics Data System (ADS)

    Brádler, Kamil; Adami, Christoph

    2016-03-01

    One-shot decoupling is a powerful primitive in quantum information theory and was hypothesized to play a role in the black hole information paradox. We study black hole dynamics modeled by a trilinear Hamiltonian whose semiclassical limit gives rise to Hawking radiation. An explicit numerical calculation of the discretized path integral of the S matrix shows that decoupling is exact in the continuous limit, implying that quantum information is perfectly transferred from the black hole to radiation. A striking consequence of decoupling is the emergence of an output radiation entropy profile that follows Page's prediction. We argue that information transfer and the emergence of Page curves is a robust feature of any multilinear interaction Hamiltonian with a bounded spectrum.

  11. An Efficient Web Page Ranking for Semantic Web

    NASA Astrophysics Data System (ADS)

    Chahal, P.; Singh, M.; Kumar, S.

    2014-01-01

    With the enormous amount of information presented on the web, the retrieval of relevant information has become a serious problem and is also the topic of research for last few years. The most common tools to retrieve information from web are search engines like Google. The Search engines are usually based on keyword searching and indexing of web pages. This approach is not very efficient as the result-set of web pages obtained include large irrelevant pages. Sometimes even the entire result-set may contain lot of irrelevant pages for the user. The next generation of search engines must address this problem. Recently, many semantic web search engines have been developed like Ontolook, Swoogle, which help in searching meaningful documents presented on semantic web. In this process the ranking of the retrieved web pages is very crucial. Some attempts have been made in ranking of semantic web pages but still the ranking of these semantic web documents is neither satisfactory and nor up to the user's expectations. In this paper we have proposed a semantic web based document ranking scheme that relies not only on the keywords but also on the conceptual instances present between the keywords. As a result only the relevant page will be on the top of the result-set of searched web pages. We explore all relevant relations between the keywords exploring the user's intention and then calculate the fraction of these relations on each web page to determine their relevance. We have found that this ranking technique gives better results than those by the prevailing methods.

  12. Exploring the use of a Facebook page in anatomy education.

    PubMed

    Jaffar, Akram Abood

    2014-01-01

    Facebook is the most popular social media site visited by university students on a daily basis. Consequently, Facebook is the logical place to start with for integrating social media technologies into education. This study explores how a faculty-administered Facebook Page can be used to supplement anatomy education beyond the traditional classroom. Observations were made on students' perceptions and effectiveness of using the Page, potential benefits and challenges of such use, and which Insights metrics best reflect user's engagement. The Human Anatomy Education Page was launched on Facebook and incorporated into anatomy resources for 157 medical students during two academic years. Students' use of Facebook and their perceptions of the Page were surveyed. Facebook's "Insights" tool was also used to evaluate Page performance during a period of 600 days. The majority of in-class students had a Facebook account which they adopted in education. Most students perceived Human Anatomy Education Page as effective in contributing to learning and favored "self-assessment" posts. The majority of students agreed that Facebook could be a suitable learning environment. The "Insights" tool revealed globally distributed fans with considerable Page interactions. The use of a faculty-administered Facebook Page provided a venue to enhance classroom teaching without intruding into students' social life. A wider educational use of Facebook should be adopted not only because students are embracing its use, but for its inherent potentials in boosting learning. The "Insights" metrics analyzed in this study might be helpful when establishing and evaluating the performance of education-oriented Facebook Pages. PMID:24022984

  13. Incidental and Context-Responsive Activation of Structure- and Function-Based Action Features during Object Identification

    ERIC Educational Resources Information Center

    Lee, Chia-lin; Middleton, Erica; Mirman, Daniel; Kalenine, Solene; Buxbaum, Laurel J.

    2013-01-01

    Previous studies suggest that action representations are activated during object processing, even when task-irrelevant. In addition, there is evidence that lexical-semantic context may affect such activation during object processing. Finally, prior work from our laboratory and others indicates that function-based ("use") and structure-based…

  14. Home Page: The Mode of Transport through the Information Superhighway

    NASA Technical Reports Server (NTRS)

    Lujan, Michelle R.

    1995-01-01

    The purpose of the project with the Aeroacoustics Branch was to create and submit a home page for the internet about branch information. In order to do this, one must also become familiar with the way that the internet operates. Learning HyperText Markup Language (HTML), and the ability to create a document using this language was the final objective in order to place a home page on the internet (World Wide Web). A manual of instructions regarding maintenance of the home page, and how to keep it up to date was also necessary in order to provide branch members with the opportunity to make any pertinent changes.

  15. Characterization of the Etna volcanic emissions through an active biomonitoring technique (moss-bags): part 2--morphological and mineralogical features.

    PubMed

    Calabrese, S; D'Alessandro, W

    2015-01-01

    Volcanic emissions were studied at Mount Etna (Italy) by using moss-bags technique. Mosses were exposed around the volcano at different distances from the active vents to evaluate the impact of volcanic emissions in the atmosphere. Morphology and mineralogy of volcanic particulate intercepted by mosses were investigated using scanning electron microscopy (SEM) equipped with energy dispersive spectrometer (EDS). Particles emitted during passive degassing activity from the two active vents, Bocca Nuova and North East Crater (BNC and NEC), were identified as silicates, sulfates and halide compounds. In addition to volcanic particles, we found evidences also of geogenic, anthropogenic and marine spray input. The study has shown the robustness of this active biomonitoring technique to collect particles, very useful in active volcanic areas characterized by continuous degassing and often not easily accessible to apply conventional sampling techniques. PMID:25311770

  16. Volcanic features of Io

    USGS Publications Warehouse

    Carr, M.H.; Masursky, H.; Strom, R.G.; Terrile, R.J.

    1979-01-01

    Volcanic activity is apparently higher on Io than on any other body in the Solar System. Its volcanic landforms can be compared with features on Earth to indicate the type of volcanism present on Io. ?? 1979 Nature Publishing Group.

  17. Where's the Noise? Key Features of Spontaneous Activity and Neural Variability Arise through Learning in a Deterministic Network.

    PubMed

    Hartmann, Christoph; Lazar, Andreea; Nessler, Bernhard; Triesch, Jochen

    2015-12-01

    Even in the absence of sensory stimulation the brain is spontaneously active. This background "noise" seems to be the dominant cause of the notoriously high trial-to-trial variability of neural recordings. Recent experimental observations have extended our knowledge of trial-to-trial variability and spontaneous activity in several directions: 1. Trial-to-trial variability systematically decreases following the onset of a sensory stimulus or the start of a motor act. 2. Spontaneous activity states in sensory cortex outline the region of evoked sensory responses. 3. Across development, spontaneous activity aligns itself with typical evoked activity patterns. 4. The spontaneous brain activity prior to the presentation of an ambiguous stimulus predicts how the stimulus will be interpreted. At present it is unclear how these observations relate to each other and how they arise in cortical circuits. Here we demonstrate that all of these phenomena can be accounted for by a deterministic self-organizing recurrent neural network model (SORN), which learns a predictive model of its sensory environment. The SORN comprises recurrently coupled populations of excitatory and inhibitory threshold units and learns via a combination of spike-timing dependent plasticity (STDP) and homeostatic plasticity mechanisms. Similar to balanced network architectures, units in the network show irregular activity and variable responses to inputs. Additionally, however, the SORN exhibits sequence learning abilities matching recent findings from visual cortex and the network's spontaneous activity reproduces the experimental findings mentioned above. Intriguingly, the network's behaviour is reminiscent of sampling-based probabilistic inference, suggesting that correlates of sampling-based inference can develop from the interaction of STDP and homeostasis in deterministic networks. We conclude that key observations on spontaneous brain activity and the variability of neural responses can be

  18. Where’s the Noise? Key Features of Spontaneous Activity and Neural Variability Arise through Learning in a Deterministic Network

    PubMed Central

    Hartmann, Christoph; Lazar, Andreea; Nessler, Bernhard; Triesch, Jochen

    2015-01-01

    Even in the absence of sensory stimulation the brain is spontaneously active. This background “noise” seems to be the dominant cause of the notoriously high trial-to-trial variability of neural recordings. Recent experimental observations have extended our knowledge of trial-to-trial variability and spontaneous activity in several directions: 1. Trial-to-trial variability systematically decreases following the onset of a sensory stimulus or the start of a motor act. 2. Spontaneous activity states in sensory cortex outline the region of evoked sensory responses. 3. Across development, spontaneous activity aligns itself with typical evoked activity patterns. 4. The spontaneous brain activity prior to the presentation of an ambiguous stimulus predicts how the stimulus will be interpreted. At present it is unclear how these observations relate to each other and how they arise in cortical circuits. Here we demonstrate that all of these phenomena can be accounted for by a deterministic self-organizing recurrent neural network model (SORN), which learns a predictive model of its sensory environment. The SORN comprises recurrently coupled populations of excitatory and inhibitory threshold units and learns via a combination of spike-timing dependent plasticity (STDP) and homeostatic plasticity mechanisms. Similar to balanced network architectures, units in the network show irregular activity and variable responses to inputs. Additionally, however, the SORN exhibits sequence learning abilities matching recent findings from visual cortex and the network’s spontaneous activity reproduces the experimental findings mentioned above. Intriguingly, the network’s behaviour is reminiscent of sampling-based probabilistic inference, suggesting that correlates of sampling-based inference can develop from the interaction of STDP and homeostasis in deterministic networks. We conclude that key observations on spontaneous brain activity and the variability of neural responses can be

  19. [The specific features of lipid metabolism and changes in the plasma activity of transaminases in patients with sepsis].

    PubMed

    Shcherbakova, L N; Iakovleva, I I; Molchanova, L V

    2004-01-01

    A parallel study of changes in the activity of transaminases and the parameters of lipid metabolism was conducted in patients with sepsis or septic shock, receiving renal replacement therapy. The multiple baseline increase in the activity of gamma-glutamyltranspeptidase was observed in about 50% of the patients and the elevated level of triglycerides and very low density-lipoprotein cholesterol in all the examinees. In case of the baseline multiple increased activity of gamma-glutamyltranspeptidase as compared with the normal physiological values, the probability of a good clinical outcome was some 67%, in the survivors, the activity of the enzyme significantly increasing during therapy. In the absence of the baseline multiple increased activity of gamma-glutamyltranspeptidase, there was a good clinical outcome provided that there were positive changes in triglycerides and very low-density lipoprotein cholesterol during therapy and its probability was about 33%. It is concluded that the activity of gamma-glutamyltranspeptidase and the concentration of triglycerides and very low-density lipoprotein cholesterol may be used to evaluate the efficiency of treatment and as predictors of the outcome of treatment in patients with sepsis and septic shock. PMID:15717510

  20. 8. DETAIL OF PAGE ONE IN VOLUME ONE OF KREGEL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. DETAIL OF PAGE ONE IN VOLUME ONE OF KREGEL WINDMILL COMPANY LEDGERS RECORDING THE FOUNDING OF THE COMPANY ON 19 AUGUST 1879. - Kregel Windmill Company Factory, 1416 Central Avenue, Nebraska City, Otoe County, NE

  1. Paging tradeoffs in distributed-shared-memory multiprocessors

    SciTech Connect

    Burger, D.C.; Hyder, R.S.; Miller, B.P.; Wood, D.A.

    1994-12-31

    Massively parallel processors have begun using commodity operating systems that support demand-paged virtual memory. To evaluate the utility of virtual memory, the authors measured the behavior of seven shared memory parallel application programs on a simulated distributed-shared-memory machine. The results (1) confirm the importance of gang CPU scheduling, (2) show that a page-faulting processor should spin rather than invoke a parallel context switch, (3) show that the parallel programs frequently touch most of their data, and (4) indicate that memory, not just CPUs, must be ``gang scheduled``. Overall, the experiments demonstrate that demand paging has limited value on current parallel machines because of the applications` synchronization and memory reference patterns and the machines` high page-fault and parallel-context-switch overheads.

  2. Ranking nodes in growing networks: When PageRank fails

    NASA Astrophysics Data System (ADS)

    Mariani, Manuel Sebastian; Medo, Matúš; Zhang, Yi-Cheng

    2015-11-01

    PageRank is arguably the most popular ranking algorithm which is being applied in real systems ranging from information to biological and infrastructure networks. Despite its outstanding popularity and broad use in different areas of science, the relation between the algorithm’s efficacy and properties of the network on which it acts has not yet been fully understood. We study here PageRank’s performance on a network model supported by real data, and show that realistic temporal effects make PageRank fail in individuating the most valuable nodes for a broad range of model parameters. Results on real data are in qualitative agreement with our model-based findings. This failure of PageRank reveals that the static approach to information filtering is inappropriate for a broad class of growing systems, and suggest that time-dependent algorithms that are based on the temporal linking patterns of these systems are needed to better rank the nodes.

  3. 110. Photocopy of plate opposite page 19 in Owen, Hints. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    110. Photocopy of plate opposite page 19 in Owen, Hints. CAMPANILE, SMITHSONIAN INSTITUTION, FROM THE NORTH-EAST - Smithsonian Institution Building, 1000 Jefferson Drive, between Ninth & Twelfth Streets, Southwest, Washington, District of Columbia, DC

  4. 107. Photocopy of plate opposite page 104 in Owen, Hints. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    107. Photocopy of plate opposite page 104 in Owen, Hints. SMITHSONIAN INSTITUTION, FROM THE NORTH-EAST - Smithsonian Institution Building, 1000 Jefferson Drive, between Ninth & Twelfth Streets, Southwest, Washington, District of Columbia, DC

  5. 112. Photocopy of plate opposite page 43 in Owen, Hints. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    112. Photocopy of plate opposite page 43 in Owen, Hints. CENTRAL SOUTHERN TOWER, SMITHSONIAN INSTITUTION; FROM THE SOUTH-WEST - Smithsonian Institution Building, 1000 Jefferson Drive, between Ninth & Twelfth Streets, Southwest, Washington, District of Columbia, DC

  6. 113. Photocopy of illustration on page 109 in Owen, Hints. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    113. Photocopy of illustration on page 109 in Owen, Hints. SOUTHERN GATEWAY, SMITHSONIAN INSTITUTION - Smithsonian Institution Building, 1000 Jefferson Drive, between Ninth & Twelfth Streets, Southwest, Washington, District of Columbia, DC

  7. 109. Photocopy of plate opposite page 75 in Owen, Hints. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    109. Photocopy of plate opposite page 75 in Owen, Hints. WEST WING, SMITHSONIAN INSTITUTION: FROM THE NORTH-EAST - Smithsonian Institution Building, 1000 Jefferson Drive, between Ninth & Twelfth Streets, Southwest, Washington, District of Columbia, DC

  8. 111. Photocopy of plate opposite page 108 in Owen, Hints. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    111. Photocopy of plate opposite page 108 in Owen, Hints. SMITHSONIAN INSTITUTION FROM THE SOUTH WEST - Smithsonian Institution Building, 1000 Jefferson Drive, between Ninth & Twelfth Streets, Southwest, Washington, District of Columbia, DC

  9. 47 CFR 22.503 - Paging geographic area authorizations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...-85. 28 (Little Rock) 90-92, 95. 29 (Kansas City) 93, 99, 123. 30 (St. Louis) 94, 96, 98. 31 (Houston... and operate sufficient facilities to cover one third of the population in the paging geographic...

  10. Progress In Automatic Reading Of Complex Typeset Pages

    NASA Astrophysics Data System (ADS)

    Vincent, Philippe

    1989-07-01

    For a long time, automatic reading has been limited to optical character recognition. one year ago, except for one high end product, all industrial software or hardware products where limited to the reading of mono-column texts without images. This does not correspond to real life needs. In a current, company, pages which need to be transformed into electronic form are not only typewritten pages, but also complex pages from professional magazines, technical manuals, financial reports and tables, administrative documents, various directories, lists of spare parts etc... The real problem of automatic reading is to transform such complex paper pages including columns, images, drawings, titles, footnotes, legends, tables, occasionally in landscape format, into a computer text file without the help of an operator. Moreover, the problem is to perform this operation at an economical cost with limited computer resources in terms of processor and memory.

  11. Book Holder And Page Turner For The Elderly And Handicapped

    NASA Technical Reports Server (NTRS)

    Kerley, James; Eklund, Wayne

    1993-01-01

    Device holds reading matter and facilitates page turning for person not having use of arms and hands. Accommodates variety of publication formats, whether book, magazine, or newspaper. Holder sits on hospital-bed table and adjusted to convenient viewing angle. Includes flat upright back support for reading matter, hinged base, and main bracket with bent-wire page holders. Top support on back extended for such large items as newspapers. Wings on back support extended for oversize materials. Reader turns page by gripping special rod via mouthpiece, applying friction cup at its tip to page, and manipulating rod. Mouthpiece wide and tapered so user grips with teeth and uses jaws to move it, rather than using tongue or lips. Helpful to older people, whose facial and mouth muscles weak.

  12. 1. Historic American Buildings Survey Annals of SF, Page 170 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Annals of SF, Page 170 Jocelyn Annin-Del Photo Taken: 1836 FOURTH OF JULY CELEBRATION YEAR BUILT 1836 - Jacob Leese House, Historic View, Grant Avenue, San Francisco, San Francisco County, CA

  13. Unsymmetric Mono- and Dinuclear Platinum(IV) Complexes Featuring an Ethylene Glycol Moiety: Synthesis, Characterization, and Biological Activity

    PubMed Central

    Pichler, Verena; Heffeter, Petra; Valiahdi, Seied M.; Kowol, Christian R.; Egger, Alexander; Berger, Walter; Jakupec, Michael A.; Galanski, Markus; Keppler, Bernhard K.

    2014-01-01

    Eight novel mononuclear and two dinuclear platinum(IV) complexes were synthesized and characterized by elemental analysis, one- and two-dimensional NMR spectroscopy, mass spectrometry, and reversed-phase HPLC (log kw) and in one case by X-ray diffraction. Cytotoxicity of the compounds was studied in three human cancer cell lines (CH1, SW480, and A549) by means of the MTT assay, featuring IC50 values to the low micromolar range. Furthermore a selected set of compounds was investigated in additional cancer cell lines (P31 and P31/cis, A2780 and A2780/cis, SW1573, 2R120, and 2R160) with regard to their resistance patterns, offering a distinctly different scheme compared to cisplatin. To gain further insights into the mode of action, drug uptake, DNA synthesis inhibition, cell cycle effects, and induction of apoptosis were determined for two characteristic substances. PMID:23194425

  14. Interactive effect of salicylic acid on some physiological features and antioxidant enzymes activity in ginger (Zingiber officinale Roscoe).

    PubMed

    Ghasemzadeh, Ali; Jaafar, Hawa Z E

    2013-01-01

    The effect of foliar salicylic acid (SA) applications (10⁻³ and 10⁻⁵ M) on activities of nitrate reductase, guaiacol peroxidase (POD), superoxide dismutases (SOD), catalase (CAT) and proline enzymes and physiological parameters was evaluated in two ginger varieties (Halia Bentong and Halia Bara) under greenhouse conditions. In both varieties, tested treatments generally enhanced photosynthetic rate and total dry weight. Photosynthetic rate increases were generally accompanied by increased or unchanged stomatal conductance levels, although intercellular CO₂ concentrations of treated plants were typically lower than in controls. Lower SA concentrations were generally more effective in enhancing photosynthetic rate and plant growth. Exogenous application of SA increased antioxidant enzyme activities and proline content; the greatest responses were obtained in plants sprayed with 10⁻⁵ M SA, with significant increases observed in CAT (20.1%), POD (45.2%), SOD (44.1%) and proline (43.1%) activities. Increased CAT activity in leaves is naturally expected to increase photosynthetic efficiency and thus net photosynthesis by maintaining a constant CO₂ supply. Our results support the idea that low SA concentrations (10⁻⁵ M) may induce nitrite reductase synthesis by mobilizing intracellular NO³⁻ and can provide protection to nitrite reductase degradation in vivo in the absence of NO³⁻. Observed positive correlations among proline, SOD, CAT and POD activities in the studied varieties suggest that increased SOD activity was accompanied by increases in CAT and POD activities because of the high demands of H₂O₂ quenching. PMID:23698049

  15. Prostate-associated gene 4 (PAGE4), an intrinsically disordered cancer/testis antigen, is a novel therapeutic target for prostate cancer.

    PubMed

    Kulkarni, Prakash; Dunker, A Keith; Weninger, Keith; Orban, John

    2016-01-01

    Prostate-associated gene 4 (PAGE4) is a remarkably prostate-specific Cancer/Testis Antigen that is highly upregulated in the human fetal prostate and its diseased states but not in the adult normal gland. PAGE4 is an intrinsically disordered protein (IDP) that functions as a stress-response protein to suppress reactive oxygen species as well as prevent DNA damage. In addition, PAGE4 is also a transcriptional regulator that potentiates transactivation by the oncogene c-Jun. c-Jun forms the AP-1 complex by heterodimerizing with members of the Fos family and plays an important role in the development and pathology of the prostate gland, underscoring the importance of the PAGE4/c-Jun interaction. HIPK1, also a component of the stress-response pathway, phosphorylates PAGE4 at T51 which is critical for its transcriptional activity. Phosphorylation induces conformational and dynamic switching in the PAGE4 ensemble leading to a new cellular function. Finally, bioinformatics evidence suggests that the PAGE4 mRNA could be alternatively spliced resulting in four potential isoforms of the polypeptide alluding to the possibility of a range of conformational ensembles with latent functions. Considered together, the data suggest that PAGE4 may represent the first molecular link between stress and prostate cancer (PCa). Thus, pharmacologically targeting PAGE4 may be a novel opportunity for treating and managing patients with PCa, especially patients with low-risk disease. PMID:27270343

  16. Prostate-associated gene 4 (PAGE4), an intrinsically disordered cancer/testis antigen, is a novel therapeutic target for prostate cancer

    PubMed Central

    Kulkarni, Prakash; Dunker, A Keith; Weninger, Keith; Orban, John

    2016-01-01

    Prostate-associated gene 4 (PAGE4) is a remarkably prostate-specific Cancer/Testis Antigen that is highly upregulated in the human fetal prostate and its diseased states but not in the adult normal gland. PAGE4 is an intrinsically disordered protein (IDP) that functions as a stress-response protein to suppress reactive oxygen species as well as prevent DNA damage. In addition, PAGE4 is also a transcriptional regulator that potentiates transactivation by the oncogene c-Jun. c-Jun forms the AP-1 complex by heterodimerizing with members of the Fos family and plays an important role in the development and pathology of the prostate gland, underscoring the importance of the PAGE4/c-Jun interaction. HIPK1, also a component of the stress-response pathway, phosphorylates PAGE4 at T51 which is critical for its transcriptional activity. Phosphorylation induces conformational and dynamic switching in the PAGE4 ensemble leading to a new cellular function. Finally, bioinformatics evidence suggests that the PAGE4 mRNA could be alternatively spliced resulting in four potential isoforms of the polypeptide alluding to the possibility of a range of conformational ensembles with latent functions. Considered together, the data suggest that PAGE4 may represent the first molecular link between stress and prostate cancer (PCa). Thus, pharmacologically targeting PAGE4 may be a novel opportunity for treating and managing patients with PCa, especially patients with low-risk disease. PMID:27270343

  17. A one-page orofacial myofunctional assessment form: a proposal.

    PubMed

    Paskay, Licia Coceani

    2012-11-01

    The author presents her own proposal of a one-page orofacial myofunctional assessment and for each item on the list a brief rationale is provided. The protocol is an easy but comprehensive form that can be faxed or emailed to referral sources as needed. As science provides more objective assessment and evaluation tools, this one-page form can be easily modified. PMID:23362751

  18. ASM Based Synthesis of Handwritten Arabic Text Pages.

    PubMed

    Dinges, Laslo; Al-Hamadi, Ayoub; Elzobi, Moftah; El-Etriby, Sherif; Ghoneim, Ahmed

    2015-01-01

    Document analysis tasks, as text recognition, word spotting, or segmentation, are highly dependent on comprehensive and suitable databases for training and validation. However their generation is expensive in sense of labor and time. As a matter of fact, there is a lack of such databases, which complicates research and development. This is especially true for the case of Arabic handwriting recognition, that involves different preprocessing, segmentation, and recognition methods, which have individual demands on samples and ground truth. To bypass this problem, we present an efficient system that automatically turns Arabic Unicode text into synthetic images of handwritten documents and detailed ground truth. Active Shape Models (ASMs) based on 28046 online samples were used for character synthesis and statistical properties were extracted from the IESK-arDB database to simulate baselines and word slant or skew. In the synthesis step ASM based representations are composed to words and text pages, smoothed by B-Spline interpolation and rendered considering writing speed and pen characteristics. Finally, we use the synthetic data to validate a segmentation method. An experimental comparison with the IESK-arDB database encourages to train and test document analysis related methods on synthetic samples, whenever no sufficient natural ground truthed data is available. PMID:26295059

  19. ASM Based Synthesis of Handwritten Arabic Text Pages

    PubMed Central

    Dinges, Laslo; Al-Hamadi, Ayoub; Elzobi, Moftah; El-etriby, Sherif; Ghoneim, Ahmed

    2015-01-01

    Document analysis tasks, as text recognition, word spotting, or segmentation, are highly dependent on comprehensive and suitable databases for training and validation. However their generation is expensive in sense of labor and time. As a matter of fact, there is a lack of such databases, which complicates research and development. This is especially true for the case of Arabic handwriting recognition, that involves different preprocessing, segmentation, and recognition methods, which have individual demands on samples and ground truth. To bypass this problem, we present an efficient system that automatically turns Arabic Unicode text into synthetic images of handwritten documents and detailed ground truth. Active Shape Models (ASMs) based on 28046 online samples were used for character synthesis and statistical properties were extracted from the IESK-arDB database to simulate baselines and word slant or skew. In the synthesis step ASM based representations are composed to words and text pages, smoothed by B-Spline interpolation and rendered considering writing speed and pen characteristics. Finally, we use the synthetic data to validate a segmentation method. An experimental comparison with the IESK-arDB database encourages to train and test document analysis related methods on synthetic samples, whenever no sufficient natural ground truthed data is available. PMID:26295059

  20. A Method for Extracting Suspected Parotid Lesions in CT Images using Feature-based Segmentation and Active Contours based on Stationary Wavelet Transform

    NASA Astrophysics Data System (ADS)

    Wu, T. Y.; Lin, S. F.

    2013-10-01

    Automatic suspected lesion extraction is an important application in computer-aided diagnosis (CAD). In this paper, we propose a method to automatically extract the suspected parotid regions for clinical evaluation in head and neck CT images. The suspected lesion tissues in low contrast tissue regions can be localized with feature-based segmentation (FBS) based on local texture features, and can be delineated with accuracy by modified active contour models (ACM). At first, stationary wavelet transform (SWT) is introduced. The derived wavelet coefficients are applied to derive the local features for FBS, and to generate enhanced energy maps for ACM computation. Geometric shape features (GSFs) are proposed to analyze each soft tissue region segmented by FBS; the regions with higher similarity GSFs with the lesions are extracted and the information is also applied as the initial conditions for fine delineation computation. Consequently, the suspected lesions can be automatically localized and accurately delineated for aiding clinical diagnosis. The performance of the proposed method is evaluated by comparing with the results outlined by clinical experts. The experiments on 20 pathological CT data sets show that the true-positive (TP) rate on recognizing parotid lesions is about 94%, and the dimension accuracy of delineation results can also approach over 93%.

  1. Book Clubs Turn the Page to Learning

    ERIC Educational Resources Information Center

    Sennett, Frank

    2006-01-01

    The nation's schools and libraries have come up with shelves full of innovative twists on the basic book club. This article offers a few of these fun and educational ideas that can be adapted for everyone from young beginning readers to teens. Teachers and librarians describe book club activities that they have found successful in: bringing…

  2. Visualizing Worlds from Words on a Page

    ERIC Educational Resources Information Center

    Parsons, Linda T.

    2006-01-01

    This study involved fourth grade children as co-researchers of their engaged, aesthetic reading experience. As members of the "Readers as Researchers Club," they documented their engagement with text--how they create, enter, and sustain the story world. The children, who self-identified as avid readers, explored the activities central to their…

  3. Deciphering solar magnetic activity. I. On the relationship between the sunspot cycle and the evolution of small magnetic features

    SciTech Connect

    McIntosh, Scott W.; Wang, Xin; Markel, Robert S.; Thompson, Michael J.; Leamon, Robert J.; Malanushenko, Anna V.; Davey, Alisdair R.; Howe, Rachel; Krista, Larisza D.; Cirtain, Jonathan W.; Gurman, Joseph B.; Pesnell, William D.

    2014-09-01

    Sunspots are a canonical marker of the Sun's internal magnetic field which flips polarity every ∼22 yr. The principal variation of sunspots, an ∼11 yr variation, modulates the amount of the magnetic field that pierces the solar surface and drives significant variations in our star's radiative, particulate, and eruptive output over that period. This paper presents observations from the Solar and Heliospheric Observatory and Solar Dynamics Observatory indicating that the 11 yr sunspot variation is intrinsically tied to the spatio-temporal overlap of the activity bands belonging to the 22 yr magnetic activity cycle. Using a systematic analysis of ubiquitous coronal brightpoints and the magnetic scale on which they appear to form, we show that the landmarks of sunspot cycle 23 can be explained by considering the evolution and interaction of the overlapping activity bands of the longer-scale variability.

  4. Detection of the end point temperature of thermal denatured protein in fish and chicken meat through SDS-PAGE electrophoresis

    NASA Astrophysics Data System (ADS)

    Gao, Hongwei; Mao, Mao; Liang, Chengzhu; Lin, Chao; Xiang, Jianhai

    2009-03-01

    Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) was applied in the detection of the end point temperature (EPT) of thermal denatured protein in fish and meat in this study. It was also used in studying the thermal denatured temperature range of proteins in salmon and chicken meat. The results show that the temperature ranges of denatured proteins were from 65°C to 75°C, and these temperature ranges were influenced by the processing methods. Through SDS-PAGE, the features of repeated heating thermal denatured proteins under the same temperature and processing time were studied. The electrophoresis patterns of thermal denatured proteins determined through repeated heating at the same temperature did not exhibit any change. For the detection of cooked fish and meat samples, they were subjected to applying the SDS-PAGE method, which revealed an EPT ranging from 60°C to 80°C.

  5. Molecular pathway activation features linked with transition from normal skin to primary and metastatic melanomas in human.

    PubMed

    Shepelin, Denis; Korzinkin, Mikhail; Vanyushina, Anna; Aliper, Alexander; Borisov, Nicolas; Vasilov, Raif; Zhukov, Nikolay; Sokov, Dmitry; Prassolov, Vladimir; Gaifullin, Nurshat; Zhavoronkov, Alex; Bhullar, Bhupinder; Buzdin, Anton

    2016-01-01

    Melanoma is the most aggressive and dangerous type of skin cancer, but its molecular mechanisms remain largely unclear. For transcriptomic data of 478 primary and metastatic melanoma, nevi and normal skin samples, we performed high-throughput analysis of intracellular molecular networks including 592 signaling and metabolic pathways. We showed that at the molecular pathway level, the formation of nevi largely resembles transition from normal skin to primary melanoma. Using a combination of bioinformatic machine learning algorithms, we identified 44 characteristic signaling and metabolic pathways connected with the formation of nevi, development of primary melanoma, and its metastases. We created a model describing formation and progression of melanoma at the level of molecular pathway activation. We discovered six novel associations between activation of metabolic molecular pathways and progression of melanoma: for allopregnanolone biosynthesis, L-carnitine biosynthesis, zymosterol biosynthesis (inhibited in melanoma), fructose 2, 6-bisphosphate synthesis and dephosphorylation, resolvin D biosynthesis (activated in melanoma), D-myo-inositol hexakisphosphate biosynthesis (activated in primary, inhibited in metastatic melanoma). Finally, we discovered fourteen tightly coordinated functional clusters of molecular pathways. This study helps to decode molecular mechanisms underlying the development of melanoma. PMID:26624979

  6. Molecular pathway activation features linked with transition from normal skin to primary and metastatic melanomas in human

    PubMed Central

    Shepelin, Denis; Korzinkin, Mikhail; Vanyushina, Anna; Aliper, Alexander; Borisov, Nicolas; Vasilov, Raif; Zhukov, Nikolay; Sokov, Dmitry; Prassolov, Vladimir; Gaifullin, Nurshat; Zhavoronkov, Alex; Bhullar, Bhupinder; Buzdin, Anton

    2016-01-01

    Melanoma is the most aggressive and dangerous type of skin cancer, but its molecular mechanisms remain largely unclear. For transcriptomic data of 478 primary and metastatic melanoma, nevi and normal skin samples, we performed high-throughput analysis of intracellular molecular networks including 592 signaling and metabolic pathways. We showed that at the molecular pathway level, the formation of nevi largely resembles transition from normal skin to primary melanoma. Using a combination of bioinformatic machine learning algorithms, we identified 44 characteristic signaling and metabolic pathways connected with the formation of nevi, development of primary melanoma, and its metastases. We created a model describing formation and progression of melanoma at the level of molecular pathway activation. We discovered six novel associations between activation of metabolic molecular pathways and progression of melanoma: for allopregnanolone biosynthesis, L-carnitine biosynthesis, zymosterol biosynthesis (inhibited in melanoma), fructose 2, 6-bisphosphate synthesis and dephosphorylation, resolvin D biosynthesis (activated in melanoma), D-myo-inositol hexakisphosphate biosynthesis (activated in primary, inhibited in metastatic melanoma). Finally, we discovered fourteen tightly coordinated functional clusters of molecular pathways. This study helps to decode molecular mechanisms underlying the development of melanoma. PMID:26624979

  7. Geographic Information Systems and Web Page Development

    NASA Technical Reports Server (NTRS)

    Reynolds, Justin

    2004-01-01

    The Facilities Engineering and Architectural Branch is responsible for the design and maintenance of buildings, laboratories, and civil structures. In order to improve efficiency and quality, the FEAB has dedicated itself to establishing a data infrastructure based on Geographic Information Systems, GIS. The value of GIS was explained in an article dating back to 1980 entitled "Need for a Multipurpose Cadastre" which stated, "There is a critical need for a better land-information system in the United States to improve land-conveyance procedures, furnish a basis for equitable taxation, and provide much-needed information for resource management and environmental planning." Scientists and engineers both point to GIS as the solution. What is GIS? According to most text books, Geographic Information Systems is a class of software that stores, manages, and analyzes mapable features on, above, or below the surface of the earth. GIS software is basically database management software to the management of spatial data and information. Simply put, Geographic Information Systems manage, analyze, chart, graph, and map spatial information. GIS can be broken down into two main categories, urban GIS and natural resource GIS. Further still, natural resource GIS can be broken down into six sub-categories, agriculture, forestry, wildlife, catchment management, archaeology, and geology/mining. Agriculture GIS has several applications, such as agricultural capability analysis, land conservation, market analysis, or whole farming planning. Forestry GIs can be used for timber assessment and management, harvest scheduling and planning, environmental impact assessment, and pest management. GIS when used in wildlife applications enables the user to assess and manage habitats, identify and track endangered and rare species, and monitor impact assessment.

  8. Color Composite of Solar Features

    NASA Technical Reports Server (NTRS)

    1998-01-01

    This composite image combines Extreme Ultravoilet Imaging Telescope (EIT)images from three wavelengths(171, 195 and 284 angstrom) into one that reveals solar features unique to each wavelength. Since the EIT images come to us from the spacecraft in black and white, they are color coded for easy identification. For this image, the nearly simultaneous images from May 1998 were each given a color code (red, yellow and blue) and merged into one.

    SOHO is a project of international cooperation between ESA and NASA. See the SOHO web page at http://sohowww.nascom.nasa.gov for more details.

  9. Polyalkoxybenzenes from plants. 5. Parsley seed extract in synthesis of azapodophyllotoxins featuring strong tubulin destabilizing activity in the sea urchin embryo and cell culture assays.

    PubMed

    Semenova, Marina N; Kiselyov, Alex S; Tsyganov, Dmitry V; Konyushkin, Leonid D; Firgang, Sergei I; Semenov, Roman V; Malyshev, Oleg R; Raihstat, Mikhail M; Fuchs, Fabian; Stielow, Anne; Lantow, Margareta; Philchenkov, Alex A; Zavelevich, Michael P; Zefirov, Nikolay S; Kuznetsov, Sergei A; Semenov, Victor V

    2011-10-27

    A series of 4-azapodophyllotoxin derivatives with modified rings B and E have been synthesized using allylpolyalkoxybenzenes from parsley seed oil. The targeted molecules were evaluated in vivo in a phenotypic sea urchin embryo assay for antimitotic and tubulin destabilizing activity. The most active compounds identified by the in vivo sea urchin embryo assay featured myristicin-derived ring E. These molecules were determined to be more potent than podophyllotoxin. Cytotoxic effects of selected molecules were further confirmed and evaluated by conventional assays with A549 and Jurkat human leukemic T-cell lines including cell growth inhibition, cell cycle arrest, cellular microtubule disruption, and induction of apoptosis. The ring B modification yielded 6-OMe substituted molecule as the most active compound. Finally, in Jurkat cells, compound induced caspase-dependent apoptosis mediated by the apical caspases-2 and -9 and not caspase-8, implying the involvement of the intrinsic caspase-9-dependent apoptotic pathway. PMID:21916509

  10. Reconstruction of eolian sequences - a function of scale, Jurassic Page sandstone, Arizona

    SciTech Connect

    Kocurek, G.; Knight, J.; Havholm, K.

    1989-03-01

    Interpretation of sequences of ergs and bed forms that comprise an eolian unit is strongly dependent on the scale of mapping. A pentagon-shaped, three-dimensional outcrop of eolian Middle Jurassic Page sandstone near Page, Arizona, measuring 36 m high and nearly 1 km in perimeter, was mapped with the aid of an electronic tacheometer. The extent and orientation of bounding surfaces and sets of cross-strata were mapped in detail, foreset orientation were measured, and a general depiction was made of the lateral and vertical distribution of stratification types within sets and of features associated with the surfaces. The level of mapping is at a middle scale with respect to architectural elements and proved adequate for an interpretation of most bed forms in terms of shape (two or three dimensions, sinuosity, symmetry, and crestline-phase relationships), size (height and width), aerodynamics (overall primary and secondary airflow patterns), and migration behavior (degree of climb and recognition of cyclicity). These interpretations allow the determination of bed-form hierarchy (simple dunes or draas) and of the bed-form type according to the descriptive (crescentic, linear) and dynamic (transverse, oblique, longitudinal) classifications. In conjunction with this level of mapping, large-scale or regional mapping was used in order to identify distinct, stacked, dune-field, and erg deposits that comprise the Page sandstone. Local mapping of the out-crop at a fine scale was necessary for refined interpretation of cyclicity, bed-form size, migration rate, and airflow pattern.

  11. The impact of salient advertisements on reading and attention on web pages.

    PubMed

    Simola, Jaana; Kuisma, Jarmo; Oörni, Anssi; Uusitalo, Liisa; Hyönä, Jukka

    2011-06-01

    Human vision is sensitive to salient features such as motion. Therefore, animation and onset of advertisements on Websites may attract visual attention and disrupt reading. We conducted three eye tracking experiments with authentic Web pages to assess whether (a) ads are efficiently ignored, (b) ads attract overt visual attention and disrupt reading, or (c) ads are covertly attended with distraction showing up indirectly in the reading performance. The Web pages contained an ad above a central text and another ad to the right of the text. In Experiments 1, 2, and 3A the task was to read for comprehension. Experiment 1 examined whether the degree of animation affects attention toward the ads. The results showed that ads were overtly attended during reading and that the dwell times on ads were the longest when the ad above was static and the other ad was animated. In Experiments 2 and 3, the ads appeared abruptly after a random time interval. The results showed that attention (i.e., the time when the eyes first entered an ad) was related to the ad onset time. This happened especially for the ad to the right, indicating that ads appearing close to the text region capture overt attention. In Experiment 3B the participants browsed the Web pages according to their own interest. The study demonstrated that salient ads attract overt visual attention and disrupt reading, but during free browsing, ads were viewed more frequently and for longer time than during reading. PMID:21604909

  12. The Candida Genome Database: the new homology information page highlights protein similarity and phylogeny.

    PubMed

    Binkley, Jonathan; Arnaud, Martha B; Inglis, Diane O; Skrzypek, Marek S; Shah, Prachi; Wymore, Farrell; Binkley, Gail; Miyasato, Stuart R; Simison, Matt; Sherlock, Gavin

    2014-01-01

    The Candida Genome Database (CGD, http://www.candidagenome.org/) is a freely available online resource that provides gene, protein and sequence information for multiple Candida species, along with web-based tools for accessing, analyzing and exploring these data. The goal of CGD is to facilitate and accelerate research into Candida pathogenesis and biology. The CGD Web site is organized around Locus pages, which display information collected about individual genes. Locus pages have multiple tabs for accessing different types of information; the default Summary tab provides an overview of the gene name, aliases, phenotype and Gene Ontology curation, whereas other tabs display more in-depth information, including protein product details for coding genes, notes on changes to the sequence or structure of the gene and a comprehensive reference list. Here, in this update to previous NAR Database articles featuring CGD, we describe a new tab that we have added to the Locus page, entitled the Homology Information tab, which displays phylogeny and gene similarity information for each locus. PMID:24185697

  13. 78 FR 51265 - 30-Day Notice of Proposed Information Collection: Application for Additional Visa Pages or...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-20

    ... Notice of Proposed Information Collection: Application for Additional Visa Pages or Miscellaneous...: Title of Information Collection: Application for Additional Visa Pages or Miscellaneous Passport... applies for the addition of visa pages to that passport, the Department must confirm the...

  14. Geographic Information Systems and Web Page Development

    NASA Technical Reports Server (NTRS)

    Reynolds, Justin

    2004-01-01

    The Facilities Engineering and Architectural Branch is responsible for the design and maintenance of buildings, laboratories, and civil structures. In order to improve efficiency and quality, the FEAB has dedicated itself to establishing a data infrastructure based on Geographic Information Systems, GIs. The value of GIS was explained in an article dating back to 1980 entitled "Need for a Multipurpose Cadastre which stated, "There is a critical need for a better land-information system in the United States to improve land-conveyance procedures, furnish a basis for equitable taxation, and provide much-needed information for resource management and environmental planning." Scientists and engineers both point to GIS as the solution. What is GIS? According to most text books, Geographic Information Systems is a class of software that stores, manages, and analyzes mapable features on, above, or below the surface of the earth. GIS software is basically database management software to the management of spatial data and information. Simply put, Geographic Information Systems manage, analyze, chart, graph, and map spatial information. At the outset, I was given goals and expectations from my branch and from my mentor with regards to the further implementation of GIs. Those goals are as follows: (1) Continue the development of GIS for the underground structures. (2) Extract and export annotated data from AutoCAD drawing files and construct a database (to serve as a prototype for future work). (3) Examine existing underground record drawings to determine existing and non-existing underground tanks. Once this data was collected and analyzed, I set out on the task of creating a user-friendly database that could be assessed by all members of the branch. It was important that the database be built using programs that most employees already possess, ruling out most AutoCAD-based viewers. Therefore, I set out to create an Access database that translated onto the web using Internet

  15. Identification of benzopyrone as a common structural feature in compounds with anti-inflammatory activity in a zebrafish phenotypic screen

    PubMed Central

    Robertson, Anne L.; Ogryzko, Nikolay V.; Henry, Katherine M.; Loynes, Catherine A.; Foulkes, Matthew J.; Meloni, Marco M.; Wang, Xingang; Ford, Christopher; Jackson, Malcolm; Ingham, Philip W.; Wilson, Heather L.; Farrow, Stuart N.; Solari, Roberto; Flower, Roderick J.; Jones, Simon; Whyte, Moira K. B.

    2016-01-01

    ABSTRACT Neutrophils are essential for host defence and are recruited to sites of inflammation in response to tissue injury or infection. For inflammation to resolve, these cells must be cleared efficiently and in a controlled manner, either by apoptosis or reverse migration. If the inflammatory response is not well-regulated, persistent neutrophils can cause damage to host tissues and contribute to the pathogenesis of chronic inflammatory diseases, which respond poorly to current treatments. It is therefore important to develop drug discovery strategies that can identify new therapeutics specifically targeting neutrophils, either by promoting their clearance or by preventing their recruitment. Our recent in vivo chemical genetic screen for accelerators of inflammation resolution identified a subset of compounds sharing a common chemical signature, the bicyclic benzopyrone rings. Here, we further investigate the mechanisms of action of the most active of this chemical series, isopimpinellin, in our zebrafish model of neutrophilic inflammation. We found that this compound targets both the recruitment and resolution phases of the inflammatory response. Neutrophil migration towards a site of injury is reduced by isopimpinellin and this occurs as a result of PI3K inhibition. We also show that isopimpinellin induces neutrophil apoptosis to drive inflammation resolution in vivo using a new zebrafish reporter line detecting in vivo neutrophil caspase-3 activity and allowing quantification of flux through the apoptotic pathway in real time. Finally, our studies reveal that clinically available ‘cromones’ are structurally related to isopimpinellin and have previously undescribed pro-resolution activity in vivo. These findings could have implications for the therapeutic use of benzopyrones in inflammatory disease. PMID:27079522

  16. Identification of benzopyrone as a common structural feature in compounds with anti-inflammatory activity in a zebrafish phenotypic screen.

    PubMed

    Robertson, Anne L; Ogryzko, Nikolay V; Henry, Katherine M; Loynes, Catherine A; Foulkes, Matthew J; Meloni, Marco M; Wang, Xingang; Ford, Christopher; Jackson, Malcolm; Ingham, Philip W; Wilson, Heather L; Farrow, Stuart N; Solari, Roberto; Flower, Roderick J; Jones, Simon; Whyte, Moira K B; Renshaw, Stephen A

    2016-06-01

    Neutrophils are essential for host defence and are recruited to sites of inflammation in response to tissue injury or infection. For inflammation to resolve, these cells must be cleared efficiently and in a controlled manner, either by apoptosis or reverse migration. If the inflammatory response is not well-regulated, persistent neutrophils can cause damage to host tissues and contribute to the pathogenesis of chronic inflammatory diseases, which respond poorly to current treatments. It is therefore important to develop drug discovery strategies that can identify new therapeutics specifically targeting neutrophils, either by promoting their clearance or by preventing their recruitment. Our recent in vivo chemical genetic screen for accelerators of inflammation resolution identified a subset of compounds sharing a common chemical signature, the bicyclic benzopyrone rings. Here, we further investigate the mechanisms of action of the most active of this chemical series, isopimpinellin, in our zebrafish model of neutrophilic inflammation. We found that this compound targets both the recruitment and resolution phases of the inflammatory response. Neutrophil migration towards a site of injury is reduced by isopimpinellin and this occurs as a result of PI3K inhibition. We also show that isopimpinellin induces neutrophil apoptosis to drive inflammation resolution in vivo using a new zebrafish reporter line detecting in vivo neutrophil caspase-3 activity and allowing quantification of flux through the apoptotic pathway in real time. Finally, our studies reveal that clinically available 'cromones' are structurally related to isopimpinellin and have previously undescribed pro-resolution activity in vivo These findings could have implications for the therapeutic use of benzopyrones in inflammatory disease. PMID:27079522

  17. fMRI Activity in Posterior Parietal Cortex Relates to the Perceptual Use of Binocular Disparity for Both Signal-In-Noise and Feature Difference Tasks

    PubMed Central

    Patten, Matthew L.; Welchman, Andrew E.

    2015-01-01

    Visually guided action and interaction depends on the brain’s ability to (a) extract and (b) discriminate meaningful targets from complex retinal inputs. Binocular disparity is known to facilitate this process, and it is an open question how activity in different parts of the visual cortex relates to these fundamental visual abilities. Here we examined fMRI responses related to performance on two different tasks (signal-in-noise “coarse” and feature difference “fine” tasks) that have been widely used in previous work, and are believed to differentially target the visual processes of signal extraction and feature discrimination. We used multi-voxel pattern analysis to decode depth positions (near vs. far) from the fMRI activity evoked while participants were engaged in these tasks. To look for similarities between perceptual judgments and brain activity, we constructed ‘fMR-metric’ functions that described decoding performance as a function of signal magnitude. Thereafter we compared fMR-metric and psychometric functions, and report an association between judged depth and fMRI responses in the posterior parietal cortex during performance on both tasks. This highlights common stages of processing during perceptual performance on these tasks. PMID:26529314

  18. Telomere 1 (POT1) gene expression and its association with telomerase activity in colorectal tumor samples with different pathological features.

    PubMed

    Izgi, Ahu; Gunal, Armagan; Yalcin, Serap; Gunduz, Ufuk

    2014-09-01

    The ends of chromosoms, telomeres are bound with a number of proteins which protect and stabilize telomeres against degredation, end to end fusion and aberrant recombinations. Telomeric DNA is bound of two groups of proteins, which are double-stranded telomeric DNA bindings proteins, and single stranded telomeric binding proteins. Among telomere binding proteins, protections of telomere 1 protein is a single stranded telomere binding proteins and suggested to be a significant player for telomere elongation and has an association with an enzyme called as telomerase which is an intrinsic reverse transcriptase. Telomerase synthesizes hexameric telomeric repeats onto the chromosomes thereby compansating telomere loss in immortal cells, such as tumor cells, whereas telomeres are shorthened with each division in normal cells. PCR-based TRAP (telomeric repeat amplification protocol) assay is a very sensitive assay for the detection of enzymatic activity of telomerase even if a few numbers of cancerous cells are available. The association between telomerase activity and hPOT1 expression in colorectal cancer is still unclear. Protein extraction was performed from specimens of matched normal and colorectal cancer specimens. Protein concentrations were determined by Bradford assay. Optimized protein concentrations were used for TRAP Assay. TRAP products were seperated by vertical gel electrophoresis on 12.5% polyacrylamide gels and visualized by silver staining. Gene expression of hPOT1 was determined by qPCR analysis. The results demonstrated that all tumor tissues were telomerase positive whereas all corresponding normal tissue was telomerase negative. Among clinicopathological findings, telomerase activity was found to be associated with stage, histology, localization, distant metastasis and lymph node metastasis of tumor in the current study. Although all of the clinicopathological findings differed in the expression of hPOT1 compared to normal tissues, they did not

  19. Synthesis, spectral features and biological activity of some novel hetarylazo dyes derived from 8-chloro-4-hydroxyl-2-quinolone

    NASA Astrophysics Data System (ADS)

    Yahyazadeh, Asieh; Yousefi, Hessamoddin

    2014-01-01

    In this study, 8-chloro-4-hydroxyl-2-quinolone was synthesized from cyclocondensation of corresponding dianilide and subsequently used as a potent coupling component with some diazotized heterocyclic amines. These compounds were characterized by UV-vis, FT-IR, 1H NMR spectroscopic techniques and elemental analysis. Absorption spectra of these dyes were measured in six polar solvents and discussed with respect to the nature of solvents and substituted groups. The effects of acid, base, temperature and concentration on the visible absorption spectra of the dyes were reported. In addition, the antimicrobial activity of the dyes was explored in detail.

  20. Characterization and Comparison of the Structural Features, Immune-Modulatory and Anti-Avian Influenza Virus Activities Conferred by Three Algal Sulfated Polysaccharides

    PubMed Central

    Song, Lin; Chen, Xiaolin; Liu, Xiaodong; Zhang, Fubo; Hu, Linfeng; Yue, Yang; Li, Kecheng; Li, Pengcheng

    2015-01-01

    Three marine macroalgae, i.e., Grateloupia filicina, Ulva pertusa and Sargassum qingdaoense, were selected as the deputies of Rhodophyta, Chlorophyta and Ochrophyta for comparative analysis of the molecular structures and biological activities of sulfated polysaccharides (SP). The ratio of water-soluble polysaccharides, the monosaccharide composition and the sulfated contents of three extracted SPs were determined, and their structures were characterized by Fourier transformation infrared spectroscopy. In addition, biological activity analysis showed that all three SPs had immune-modulatory activity both in vitro and in vivo, and SPs from S. qingdaoense had the best effect. Further bioassays showed that three SPs could not only enhance the immunity level stimulated by inactivated avian influenza virus (AIV) in vivo but also significantly inhibited the activity of activated AIV (H9N2 subtype) in vitro. G. filicina SP exhibited the strongest anti-AIV activity. These results revealed the variations in structural features and bioactivities among three SPs and indicated the potential adjuvants for immune-enhancement and anti-AIV. PMID:26729137

  1. Characterization and Comparison of the Structural Features, Immune-Modulatory and Anti-Avian Influenza Virus Activities Conferred by Three Algal Sulfated Polysaccharides.

    PubMed

    Song, Lin; Chen, Xiaolin; Liu, Xiaodong; Zhang, Fubo; Hu, Linfeng; Yue, Yang; Li, Kecheng; Li, Pengcheng

    2016-01-01

    Three marine macroalgae, i.e., Grateloupia filicina, Ulva pertusa and Sargassum qingdaoense, were selected as the deputies of Rhodophyta, Chlorophyta and Ochrophyta for comparative analysis of the molecular structures and biological activities of sulfated polysaccharides (SP). The ratio of water-soluble polysaccharides, the monosaccharide composition and the sulfated contents of three extracted SPs were determined, and their structures were characterized by Fourier transformation infrared spectroscopy. In addition, biological activity analysis showed that all three SPs had immune-modulatory activity both in vitro and in vivo, and SPs from S. qingdaoense had the best effect. Further bioassays showed that three SPs could not only enhance the immunity level stimulated by inactivated avian influenza virus (AIV) in vivo but also significantly inhibited the activity of activated AIV (H9N2 subtype) in vitro. G. filicina SP exhibited the strongest anti-AIV activity. These results revealed the variations in structural features and bioactivities among three SPs and indicated the potential adjuvants for immune-enhancement and anti-AIV. PMID:26729137

  2. Physical activity

    MedlinePlus

    ... time they spend watching TV and using a computer and other electronic devices. All of these activities ... U.S. Department of Health and Human Services. Physical Activity Guidelines for Americans: Recommendation ... Page last updated: ...

  3. Use of Feature-Film Videocassette Rentals in the Classroom.

    ERIC Educational Resources Information Center

    Fradkin, Bernard

    1986-01-01

    Discusses the position of a media copyright attorney on the classroom use of lawfully obtained, rented feature-film videocassettes. Describes the College of DuPage's radio-based course, "Film as Literature," which depends on student rental access to feature films. (DMM)

  4. Network and User-Perceived Performance of Web Page Retrievals

    NASA Technical Reports Server (NTRS)

    Kruse, Hans; Allman, Mark; Mallasch, Paul

    1998-01-01

    The development of the HTTP protocol has been driven by the need to improve the network performance of the protocol by allowing the efficient retrieval of multiple parts of a web page without the need for multiple simultaneous TCP connections between a client and a server. We suggest that the retrieval of multiple page elements sequentially over a single TCP connection may result in a degradation of the perceived performance experienced by the user. We attempt to quantify this perceived degradation through the use of a model which combines a web retrieval simulation and an analytical model of TCP operation. Starting with the current HTTP/l.1 specification, we first suggest a client@side heuristic to improve the perceived transfer performance. We show that the perceived speed of the page retrieval can be increased without sacrificing data transfer efficiency. We then propose a new client/server extension to the HTTP/l.1 protocol to allow for the interleaving of page element retrievals. We finally address the issue of the display of advertisements on web pages, and in particular suggest a number of mechanisms which can make efficient use of IP multicast to send advertisements to a number of clients within the same network.

  5. Automatic comic page image understanding based on edge segment analysis

    NASA Astrophysics Data System (ADS)

    Liu, Dong; Wang, Yongtao; Tang, Zhi; Li, Luyuan; Gao, Liangcai

    2013-12-01

    Comic page image understanding aims to analyse the layout of the comic page images by detecting the storyboards and identifying the reading order automatically. It is the key technique to produce the digital comic documents suitable for reading on mobile devices. In this paper, we propose a novel comic page image understanding method based on edge segment analysis. First, we propose an efficient edge point chaining method to extract Canny edge segments (i.e., contiguous chains of Canny edge points) from the input comic page image; second, we propose a top-down scheme to detect line segments within each obtained edge segment; third, we develop a novel method to detect the storyboards by selecting the border lines and further identify the reading order of these storyboards. The proposed method is performed on a data set consisting of 2000 comic page images from ten printed comic series. The experimental results demonstrate that the proposed method achieves satisfactory results on different comics and outperforms the existing methods.

  6. Synthesis, spectral features and biological activity of some novel hetarylazo dyes derived from 6-amino-1,3-dimethyluracil

    NASA Astrophysics Data System (ADS)

    Yousefi, Hessamoddin; Yahyazadeh, Asieh; Yazdanbakhsh, Mohammad Reza; Rassa, Mehdi; Moradi-e-Rufchahi, Enayat O.'llah

    2012-05-01

    A series of hetarylazoaminouracil dyes were prepared by coupling of 6-amino-1,3-dimethyluracil with eight diazotized heterocyclic amines in nitrosyl sulphuric acid. The prepared azo dyes were characterized by UV-Vis, FT-IR, 13C NMR, 1H NMR spectroscopic techniques and elemental analysis. The solvatochromism of dyes was evaluated with respect to wavelength of maximum absorption (λmax) in seven solvents with different polarities: acetic acid, methanol, water, chloroform, acetonitrile, dimethyl sulfoxide and dimethyl formamide. The effects of acid, base and concentration of the dye on the visible absorption spectra were also reported. In addition, the antimicrobial activity of the synthesized dyes was evaluated on Escherichia coli, Bacillus subtilis, Micrococcus leuteus and Pseudomonas aeruginosa.

  7. Electronic Structure and Multicatalytic Features of Redox-Active Bis(arylimino)acenaphthene (BIAN)-Derived Ruthenium Complexes.

    PubMed

    Singha Hazari, Arijit; Ray, Ritwika; Hoque, Md Asmaul; Lahiri, Goutam Kumar

    2016-08-15

    The article examines the newly designed and structurally characterized redox-active BIAN-derived [Ru(trpy)(R-BIAN)Cl]ClO4 ([1a]ClO4-[1c]ClO4), [Ru(trpy)(R-BIAN)(H2O)](ClO4)2 ([3a](ClO4)2-[3c](ClO4)2), and BIAO-derived [Ru(trpy)(BIAO)Cl]ClO4 ([2a]ClO4) (trpy = 2,2':6',2''-terpyridine, R-BIAN = bis(arylimino)acenaphthene (R = H (1a(+), 3a(2+)), 4-OMe (1b(+), 3b(2+)), 4-NO2 (1c(+), 3c(2+)), BIAO = [N-(phenyl)imino]acenapthenone). The experimental (X-ray, (1)H NMR, spectroelectrochemistry, EPR) and DFT/TD-DFT calculations of 1a(n)-1c(n) or 2a(n) collectively establish {Ru(II)-BIAN(0)} or {Ru(II)-BIAO(0)} configuration in the native state, metal-based oxidation to {Ru(III)-BIAN(0)} or {Ru(III)-BIAO(0)}, and successive electron uptake processes by the α-diimine fragment, followed by trpy and naphthalene π-system of BIAN or BIAO, respectively. The impact of the electron-withdrawing NO2 function in the BIAN moiety in 1c(+) has been reflected in the five nearby reduction steps within the accessible potential limit of -2 V versus SCE, leading to a fully reduced BIAN(4-) state in [1c](4-). The aqua derivatives ({Ru(II)-OH2}, 3a(2+)-3c(2+)) undergo simultaneous 2e(-)/2H(+) transfer to the corresponding {Ru(IV)═O} state and the catalytic current associated with the Ru(IV)/Ru(V) response probably implies its involvement in the electrocatalytic water oxidation. The aqua derivatives (3a(2+)-3c(2+)) are efficient and selective precatalysts in transforming a wide variety of alkenes to corresponding epoxides in the presence of PhI(OAc)2 as an oxidant in CH2Cl2 at 298 K as well as oxidation of primary, secondary, and heterocyclic alcohols with a large substrate scope with H2O2 as the stoichiometric oxidant in CH3CN at 343 K. The involvement of the {Ru(IV)═O} intermediate as the active catalyst in both the oxidation processes has been ascertained via a sequence of experimental evidence. PMID:27482834

  8. Features of Recently Transmitted HIV-1 Clade C Viruses that Impact Antibody Recognition: Implications for Active and Passive Immunization

    PubMed Central

    Rademeyer, Cecilia; Korber, Bette; Seaman, Michael S.; Giorgi, Elena E.; Thebus, Ruwayhida; Robles, Alexander; Sheward, Daniel J.; Wagh, Kshitij; Carey, Brittany R.; Gao, Hongmei; Greene, Kelli M.; Tang, Haili; Marais, Jinny C.; Diphoko, Thabo E.; Hraber, Peter; Tumba, Nancy; Moore, Penny L.; Gray, Glenda E.; Kublin, James; McElrath, M. Juliana; Vermeulen, Marion; Middelkoop, Keren; Bekker, Linda-Gail; Hoelscher, Michael; Maboko, Leonard; Makhema, Joseph; Robb, Merlin L.; Abdool Karim, Salim; Abdool Karim, Quarraisha; Kim, Jerome H.; Hahn, Beatrice H.; Gao, Feng; Swanstrom, Ronald; Morris, Lynn; Montefiori, David C.; Williamson, Carolyn

    2016-01-01

    The development of biomedical interventions to reduce acquisition of HIV-1 infection remains a global priority, however their potential effectiveness is challenged by very high HIV-1 envelope diversity. Two large prophylactic trials in high incidence, clade C epidemic regions in southern Africa are imminent; passive administration of the monoclonal antibody VRC01, and active immunization with a clade C modified RV144-like vaccines. We have created a large representative panel of C clade viruses to enable assessment of antibody responses to vaccines and natural infection in Southern Africa, and we investigated the genotypic and neutralization properties of recently transmitted clade C viruses to determine how viral diversity impacted antibody recognition. We further explore the implications of these findings for the potential effectiveness of these trials. A panel of 200 HIV-1 Envelope pseudoviruses was constructed from clade C viruses collected within the first 100 days following infection. Viruses collected pre-seroconversion were significantly more resistant to serum neutralization compared to post-seroconversion viruses (p = 0.001). Over 13 years of the study as the epidemic matured, HIV-1 diversified (p = 0.0009) and became more neutralization resistant to monoclonal antibodies VRC01, PG9 and 4E10. When tested at therapeutic levels (10ug/ml), VRC01 only neutralized 80% of viruses in the panel, although it did exhibit potent neutralization activity against sensitive viruses (IC50 titres of 0.42 μg/ml). The Gp120 amino acid similarity between the clade C panel and candidate C-clade vaccine protein boosts (Ce1086 and TV1) was 77%, which is 8% more distant than between CRF01_AE viruses and the RV144 CRF01_AE immunogen. Furthermore, two vaccine signature sites, K169 in V2 and I307 in V3, associated with reduced infection risk in RV144, occurred less frequently in clade C panel viruses than in CRF01_AE viruses from Thailand. Increased resistance of pre

  9. Structural Features and Anti-coagulant Activity of the Sulphated Polysaccharide SPS-CF from a Green Alga Capsosiphon fulvescens.

    PubMed

    Synytsya, Andriy; Choi, Doo Jin; Pohl, Radek; Na, Ye Seul; Capek, Peter; Lattová, Erika; Taubner, Tomáš; Choi, Ji Won; Lee, Chang Won; Park, Jae Kweon; Kim, Woo Jung; Kim, Sung Min; Lee, Jisun; Park, Yong Il

    2015-12-01

    Previously, we reported that the sulphated polysaccharides (SPS)-CF, a water-soluble polysaccharide isolated and purified from Korean green alga Maesaengi (Capsosiphon fulvescens, Chlorophyta), is a glucuronogalactomannan based mainly on the monosaccharide composition determined by high-performance liquid chromatography (HPLC) analysis after 1-phenyl-3-methyl-5-pyrazolone (PMP) labelling of sugars in the acid (trifluoroacetic acid (TFA)) hydrolyzates of SPS-CF, which showed mannose (55.4 mol %), galactose (25.3 mol %) and glucuronic acid (16.3 mol %) as major sugars (Na et al., Int Immunopharmacol 10:364-370, 2010). However, the results of the present study re-performed for monosaccharide composition of this polysaccharide using, in addition to HPLC of PMP-labelled sugars, other separation methods, i.e. high-performance anion-exchange chromatography with pulsed amperometric detection (HPAEC-PAD), gas chromatography with flame ionising detection (GC-FID) and thin-layer chromatography (TLC), clearly demonstrated that the most prominent neutral monosaccharides of SPS-CF are xylose (38.6-49.4 mol %) and rhamnose (39.6-45 mol %), while mannose and galactose are present at a much lesser extent or in negligible amount. These extensive monosaccharide analyses, correlation nuclear magnetic resonance (NMR), electrospray ionization mass spectrometry (ESI-MS) and matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) measurements confirmed the sulphated glucuronorhamnoxylan (ulvan) type of SPS-CF polysaccharide, whose backbone is composed of alternating sequence of 4-linked L-rhamnose-3-sulphate and D-xylose residues (ulvobiose U3s) carrying monomeric D-glucuronic acid or D-glucuronic acid-3-sulphate on O-2 of some L-rhamnose-3-sulphate units as the side chains. The SPS-CF exhibited significant in vitro anti-coagulant activity by which the activated partial thromboplastin time (aPTT) and thrombin time (TT) were significantly prolonged. The results of this

  10. Features of Recently Transmitted HIV-1 Clade C Viruses that Impact Antibody Recognition: Implications for Active and Passive Immunization.

    PubMed

    Rademeyer, Cecilia; Korber, Bette; Seaman, Michael S; Giorgi, Elena E; Thebus, Ruwayhida; Robles, Alexander; Sheward, Daniel J; Wagh, Kshitij; Garrity, Jetta; Carey, Brittany R; Gao, Hongmei; Greene, Kelli M; Tang, Haili; Bandawe, Gama P; Marais, Jinny C; Diphoko, Thabo E; Hraber, Peter; Tumba, Nancy; Moore, Penny L; Gray, Glenda E; Kublin, James; McElrath, M Juliana; Vermeulen, Marion; Middelkoop, Keren; Bekker, Linda-Gail; Hoelscher, Michael; Maboko, Leonard; Makhema, Joseph; Robb, Merlin L; Abdool Karim, Salim; Abdool Karim, Quarraisha; Kim, Jerome H; Hahn, Beatrice H; Gao, Feng; Swanstrom, Ronald; Morris, Lynn; Montefiori, David C; Williamson, Carolyn

    2016-07-01

    The development of biomedical interventions to reduce acquisition of HIV-1 infection remains a global priority, however their potential effectiveness is challenged by very high HIV-1 envelope diversity. Two large prophylactic trials in high incidence, clade C epidemic regions in southern Africa are imminent; passive administration of the monoclonal antibody VRC01, and active immunization with a clade C modified RV144-like vaccines. We have created a large representative panel of C clade viruses to enable assessment of antibody responses to vaccines and natural infection in Southern Africa, and we investigated the genotypic and neutralization properties of recently transmitted clade C viruses to determine how viral diversity impacted antibody recognition. We further explore the implications of these findings for the potential effectiveness of these trials. A panel of 200 HIV-1 Envelope pseudoviruses was constructed from clade C viruses collected within the first 100 days following infection. Viruses collected pre-seroconversion were significantly more resistant to serum neutralization compared to post-seroconversion viruses (p = 0.001). Over 13 years of the study as the epidemic matured, HIV-1 diversified (p = 0.0009) and became more neutralization resistant to monoclonal antibodies VRC01, PG9 and 4E10. When tested at therapeutic levels (10ug/ml), VRC01 only neutralized 80% of viruses in the panel, although it did exhibit potent neutralization activity against sensitive viruses (IC50 titres of 0.42 μg/ml). The Gp120 amino acid similarity between the clade C panel and candidate C-clade vaccine protein boosts (Ce1086 and TV1) was 77%, which is 8% more distant than between CRF01_AE viruses and the RV144 CRF01_AE immunogen. Furthermore, two vaccine signature sites, K169 in V2 and I307 in V3, associated with reduced infection risk in RV144, occurred less frequently in clade C panel viruses than in CRF01_AE viruses from Thailand. Increased resistance of pre

  11. Digital database of mining-related features at selected historic and active phosphate mines, Bannock, Bear Lake, Bingham, and Caribou counties, Idaho

    USGS Publications Warehouse

    Causey, J. Douglas; Moyle, Phillip R.

    2001-01-01

    This report provides a description of data and processes used to produce a spatial database that delineates mining-related features in areas of historic and active phosphate mining in the core of the southeastern Idaho phosphate resource area. The data have varying degrees of accuracy and attribution detail. Classification of areas by type of mining-related activity at active mines is generally detailed; however, the spatial coverage does not differentiate mining-related surface disturbance features at many of the closed or inactive mines. Nineteen phosphate mine sites are included in the study. A total of 5,728 hc (14,154 ac), or more than 57 km2 (22 mi2), of phosphate mining-related surface disturbance are documented in the spatial coverage of the core of the southeast Idaho phosphate resource area. The study includes 4 active phosphate mines—Dry Valley, Enoch Valley, Rasmussen Ridge, and Smoky Canyon—and 15 historic phosphate mines—Ballard, Champ, Conda, Diamond Gulch, Gay, Georgetown Canyon, Henry, Home Canyon, Lanes Creek, Maybe Canyon, Mountain Fuel, Trail Canyon, Rattlesnake Canyon, Waterloo, and Wooley Valley. Spatial data on the inactive historic mines is relatively up-to-date; however, spatially described areas for active mines are based on digital maps prepared in early 1999. The inactive Gay mine has the largest total area of disturbance: 1,917 hc (4,736 ac) or about 19 km2 (7.4 mi2). It encompasses over three times the disturbance area of the next largest mine, the Conda mine with 607 hc (1,504 ac), and it is nearly four times the area of the Smoky Canyon mine, the largest of the active mines with 497 hc (1,228 ac). The wide range of phosphate mining-related surface disturbance features (approximately 80) were reduced to 13 types or features used in this study—adit and pit, backfilled mine pit, facilities, mine pit, ore stockpile, railroad, road, sediment catchment, tailings or tailings pond, topsoil stockpile, water reservoir, and disturbed

  12. A Detailed Data-Driven Network Model of Prefrontal Cortex Reproduces Key Features of In Vivo Activity.

    PubMed

    Hass, Joachim; Hertäg, Loreen; Durstewitz, Daniel

    2016-05-01

    The prefrontal cortex is centrally involved in a wide range of cognitive functions and their impairment in psychiatric disorders. Yet, the computational principles that govern the dynamics of prefrontal neural networks, and link their physiological, biochemical and anatomical properties to cognitive functions, are not well understood. Computational models can help to bridge the gap between these different levels of description, provided they are sufficiently constrained by experimental data and capable of predicting key properties of the intact cortex. Here, we present a detailed network model of the prefrontal cortex, based on a simple computationally efficient single neuron model (simpAdEx), with all parameters derived from in vitro electrophysiological and anatomical data. Without additional tuning, this model could be shown to quantitatively reproduce a wide range of measures from in vivo electrophysiological recordings, to a degree where simulated and experimentally observed activities were statistically indistinguishable. These measures include spike train statistics, membrane potential fluctuations, local field potentials, and the transmission of transient stimulus information across layers. We further demonstrate that model predictions are robust against moderate changes in key parameters, and that synaptic heterogeneity is a crucial ingredient to the quantitative reproduction of in vivo-like electrophysiological behavior. Thus, we have produced a physiologically highly valid, in a quantitative sense, yet computationally efficient PFC network model, which helped to identify key properties underlying spike time dynamics as observed in vivo, and can be harvested for in-depth investigation of the links between physiology and cognition. PMID:27203563

  13. Novel 4-anilinoquinazoline derivatives featuring an 1-adamantyl moiety as potent EGFR inhibitors with enhanced activity against NSCLC cell lines.

    PubMed

    Yu, Haiqing; Li, Yanxia; Ge, Yang; Song, Zhendong; Wang, Changyuan; Huang, Shanshan; Jin, Yue; Han, Xu; Zhen, Yuhong; Liu, Kexin; Zhou, Youwen; Ma, Xiaodong

    2016-03-01

    With the aim of overcoming gefitinib resistance, a series of novel quinazoline derivatives bearing an adamantyl group on the aniline ring were synthesized as potent epidermal growth factor receptor (EGFR) inhibitors. Most of these analogues are comparable to gefitinib in their ability to inhibit non-small cell lung cancer (NSCLC) cell lines, and several also exhibited significantly enhanced anti-tumor potency. Specifically, compound 3d, with an IC50 value of 2.06 μM against A431 cells with the wild-type EGFR and of 0.009 μM against the gefitinib-sensitive cells, displayed approximately 5-fold higher potency than the lead compound to inhibit the cells harboring the EGFR(T790M) mutant. In addition, the molecular simulation and Western blot analysis results also indicated that these compounds effectively interfered with the EGFR(T790M) activity, and may serve as a new alternative structure to develop more effective antitumor agents. PMID:26829280

  14. Associations between Moderate-to-Vigorous Physical Activity and Neighbourhood Recreational Facilities: The Features of the Facilities Matter

    PubMed Central

    Lee, Ka Yiu; Lee, Paul H.; Macfarlane, Duncan

    2014-01-01

    Objectives: To examine the associations between objectively-assessed moderate-to-vigorous physical activity (MVPA) and perceived/objective measures of neighbourhood recreational facilities categorized into indoor or outdoor, public, residential or commercial facilities. The associations between facility perceptions and objectively-assessed numbers of recreational facilities were also examined. Method: A questionnaire was used on 480 adults to measure local facility perceptions, with 154 participants wearing ActiGraph accelerometers for ≥4 days. The objectively-assessed number of neighbourhood recreational facilities were examined using direct observations and Geographical Information System data. Results: Both positive and negative associations were found between MVPA and perceived/objective measures of recreational facilities. Some associations depended on whether the recreational facilities were indoor or outdoor, public or residential facilities. The objectively-assessed number of most public recreational facilities was associated with the corresponding facility perceptions, but the size of effect was generally lower than for residential recreational facilities. Conclusions: The objectively-assessed number of residential outdoor table tennis courts and public indoor swimming pools, the objectively-assessed presence of tennis courts and swimming pools, and the perceived presence of bike lanes and swimming pools were positive determinants of MVPA. It is suggested to categorize the recreational facilities into smaller divisions in order to identify unique associations with MVPA. PMID:25485980

  15. Common and distinct features of mammary tumors driven by Pten-deletion or activating Pik3ca mutation.

    PubMed

    Liu, Jeff C; Wang, Dong-Yu; Egan, Sean E; Zacksenhaus, Eldad

    2016-02-23

    PTEN loss and PIK3CA activation both promote the accumulation of phosphatidylinositol (3, 4, 5)-trisphosphate (PIP3). While these proteins also have distinct biochemical functions, beyond the regulation of PIP3, little is known about the consequences of these differences in vivo. Here, we directly compared cancer signalling in mammary tumors from MMTV-Cre:Ptenf/f and MMTV-Cre:Pik3caLSL-H1047R mice. Using unsupervised hierarchical clustering we found that whereas MMTV-Cre:Pik3caLSL-H1047R-derived tumors fall into two separate groups, designated squamous-likeEx and class14Ex, MMTV-Cre:Ptenf/f tumors cluster as one group together with PIK3CAH1047R class14Ex, exhibiting a 'luminal' expression profile. Gene Set Enrichment Analysis (GSEA) of Pten∆ and PIK3CAH1047R class14Ex tumors revealed very similar profiles of signalling pathways as well as some interesting differences. Analysis of 18 signalling signatures revealed that PI3K signalling is significantly induced whereas EGFR signalling is significantly reduced in Pten∆ versus PIK3CAH1047R tumors. Thus, Pten∆ and PIK3CAH1047R tumors exhibit discernable differences that may impact tumorigenesis and response to therapy. PMID:26814435

  16. A Detailed Data-Driven Network Model of Prefrontal Cortex Reproduces Key Features of In Vivo Activity

    PubMed Central

    Hass, Joachim; Hertäg, Loreen; Durstewitz, Daniel

    2016-01-01

    The prefrontal cortex is centrally involved in a wide range of cognitive functions and their impairment in psychiatric disorders. Yet, the computational principles that govern the dynamics of prefrontal neural networks, and link their physiological, biochemical and anatomical properties to cognitive functions, are not well understood. Computational models can help to bridge the gap between these different levels of description, provided they are sufficiently constrained by experimental data and capable of predicting key properties of the intact cortex. Here, we present a detailed network model of the prefrontal cortex, based on a simple computationally efficient single neuron model (simpAdEx), with all parameters derived from in vitro electrophysiological and anatomical data. Without additional tuning, this model could be shown to quantitatively reproduce a wide range of measures from in vivo electrophysiological recordings, to a degree where simulated and experimentally observed activities were statistically indistinguishable. These measures include spike train statistics, membrane potential fluctuations, local field potentials, and the transmission of transient stimulus information across layers. We further demonstrate that model predictions are robust against moderate changes in key parameters, and that synaptic heterogeneity is a crucial ingredient to the quantitative reproduction of in vivo-like electrophysiological behavior. Thus, we have produced a physiologically highly valid, in a quantitative sense, yet computationally efficient PFC network model, which helped to identify key properties underlying spike time dynamics as observed in vivo, and can be harvested for in-depth investigation of the links between physiology and cognition. PMID:27203563

  17. Common and distinct features of mammary tumors driven by Pten-deletion or activating Pik3ca mutation

    PubMed Central

    Liu, Jeff C.; Wang, Dong-Yu; Egan, Sean E.; Zacksenhaus, Eldad

    2016-01-01

    PTEN loss and PIK3CA activation both promote the accumulation of phosphatidylinositol (3, 4, 5)-trisphosphate (PIP3). While these proteins also have distinct biochemical functions, beyond the regulation of PIP3, little is known about the consequences of these differences in vivo. Here, we directly compared cancer signalling in mammary tumors from MMTV-Cre:Ptenf/f and MMTV-Cre:Pik3caLSL-H1047R mice. Using unsupervised hierarchical clustering we found that whereas MMTV-Cre:Pik3caLSL-H1047R-derived tumors fall into two separate groups, designated squamous-likeEx and class14Ex, MMTV-Cre:Ptenf/f tumors cluster as one group together with PIK3CAH1047R class14Ex, exhibiting a ‘luminal’ expression profile. Gene Set Enrichment Analysis (GSEA) of PtenΔ and PIK3CAH1047R class14Ex tumors revealed very similar profiles of signalling pathways as well as some interesting differences. Analysis of 18 signalling signatures revealed that PI3K signalling is significantly induced whereas EGFR signalling is significantly reduced in PtenΔ versus PIK3CAH1047R tumors. Thus, PtenΔ and PIK3CAH1047R tumors exhibit discernable differences that may impact tumorigenesis and response to therapy. PMID:26814435

  18. WALK 2.0: Examining the effectiveness of Web 2.0 features to increase physical activity in a ‘real world’ setting: an ecological trial

    PubMed Central

    Caperchione, Cristina M; Kolt, Gregory S; Savage, Trevor N; Rosenkranz, Richard R; Maeder, Anthony J; Vandelanotte, Corneel; Duncan, Mitch J; Van Itallie, Anetta; Tague, Rhys; Mummery, W Kerry

    2014-01-01

    Introduction Low levels of health-enhancing physical activity require novel approaches that have the potential to reach broad populations. Web-based interventions are a popular approach for behaviour change given their wide reach and accessibility. However, challenges with participant engagement and retention reduce the long-term maintenance of behaviour change. Web 2.0 features present a new and innovative online environment supporting greater interactivity, with the potential to increase engagement and retention. In order to understand the applicability of these innovative interventions for the broader population, ‘real-world’ interventions implemented under ‘everyday conditions’ are required. The aim of this study is to investigate the difference in physical activity behaviour between individuals using a traditional Web 1.0 website with those using a novel Web 2.0 website. Methods and analysis In this study we will aim to recruit 2894 participants. Participants will be recruited from individuals who register with a pre-existing health promotion website that currently provides Web 1.0 features (http://www.10000steps.org.au). Eligible participants who provide informed consent will be randomly assigned to one of the two trial conditions: the pre-existing 10 000 Steps website (with Web 1.0 features) or the newly developed WALK 2.0 website (with Web 2.0 features). Primary and secondary outcome measures will be assessed by self-report at baseline, 3 months and 12 months, and include: physical activity behaviour, height and weight, Internet self-efficacy, website usability, website usage and quality of life. Ethics and dissemination This study has received ethics approval from the University of Western Sydney Human Research Ethics Committee (Reference Number H8767) and has been funded by the National Health and Medical Research Council (Reference Number 589903). Study findings will be disseminated widely through peer-reviewed publications, academic

  19. Lead users’ ideas on core features to support physical activity in rheumatoid arthritis: a first step in the development of an internet service using participatory design

    PubMed Central

    2014-01-01

    Background Despite the growing evidence of the benefits of physical activity (PA) in individuals with rheumatoid arthritis (RA), the majority is not physically active enough. An innovative strategy is to engage lead users in the development of PA interventions provided over the internet. The aim was to explore lead users’ ideas and prioritization of core features in a future internet service targeting adoption and maintenance of healthy PA in people with RA. Methods Six focus group interviews were performed with a purposively selected sample of 26 individuals with RA. Data were analyzed with qualitative content analysis and quantification of participants’ prioritization of most important content. Results Six categories were identified as core features for a future internet service: up-to-date and evidence-based information and instructions, self-regulation tools, social interaction, personalized set-up, attractive design and content, and access to the internet service. The categories represented four themes, or core aspects, important to consider in the design of the future service: (1) content, (2) customized options, (3) user interface and (4) access and implementation. Conclusions This is, to the best of our knowledge, the first study involving people with RA in the development of an internet service to support the adoption and maintenance of PA. Participants helped identifying core features and aspects important to consider and further explore during the next phase of development. We hypothesize that involvement of lead users will make transfer from theory to service more adequate and user-friendly and therefore will be an effective mean to facilitate PA behavior change. PMID:24655757

  20. The 2006-2007 Active Phase Of Anomalous X-Ray Pulsar 4U 0142+61: Radiative and Timing Changes, Bursts, and Burst Spectral Features

    NASA Technical Reports Server (NTRS)

    Gavril, Fotis P.; Dib, Rim; Kaspi, Victoria M.

    2009-01-01

    After at least 6 years of quiescence, Anomalous X-ray Pulsar (AXP) 4U 0142+61 entered an active phase in 2006 March that lasted several months and included six X-ray bursts as well as many changes in the persistent X-ray emission. The bursts, the first seen from this AXP in >11 years of Rossi X-ray Timing Explorer monitoring, all occurred in the interval between 2006 April 6 and 2007 February 7. The burst durations ranged from 8-3x10(exp 3)s. The first five burst spectra are well modeled by blackbodies, with temperatures kT approx. 2 - 6 keV. However, the sixth burst had a complicated spectrum that is well characterized by a blackbody plus three emission features whose amplitude varied throughout the burst. The most prominent feature was at 14.0 keV. Upon entry into the active phase the pulsar showed a significant change in pulse morphology and a likely timing glitch. The glitch had a total frequency jump of (1.9+/-0.4)x10(exp -7) Hz, which recovered with a decay time of 17+/-2 days by more than the initial jump, implying a net spin-down of the pulsar. We discuss these events in the context of the magnetar model.

  1. Fast 3D Surface Extraction 2 pages (including abstract)

    SciTech Connect

    Sewell, Christopher Meyer; Patchett, John M.; Ahrens, James P.

    2012-06-05

    Ocean scientists searching for isosurfaces and/or thresholds of interest in high resolution 3D datasets required a tedious and time-consuming interactive exploration experience. PISTON research and development activities are enabling ocean scientists to rapidly and interactively explore isosurfaces and thresholds in their large data sets using a simple slider with real time calculation and visualization of these features. Ocean Scientists can now visualize more features in less time, helping them gain a better understanding of the high resolution data sets they work with on a daily basis. Isosurface timings (512{sup 3} grid): VTK 7.7 s, Parallel VTK (48-core) 1.3 s, PISTON OpenMP (48-core) 0.2 s, PISTON CUDA (Quadro 6000) 0.1 s.

  2. General features

    SciTech Connect

    Wallace, R.E.

    1990-01-01

    The San Andreas fault system, a complex of faults that display predominantly large-scale strike slip, is part of an even more complex system of faults, isolated segments of the East Pacific Rise, and scraps of plates lying east of the East Pacific Rise that collectively separate the North American plate from the Pacific plate. This chapter briefly describes the San Andreas fault system, its setting along the Pacific Ocean margin of North America, its extent, and the patterns of faulting. Only selected characteristics are described, and many features are left for depictions on maps and figures.

  3. A tactile paging system for deaf-blind people, phase 1. [human factors engineering of bioinstrumentation

    NASA Technical Reports Server (NTRS)

    Baer, J. A.

    1976-01-01

    A tactile paging system for deaf-blind people has been brought from the concept stage to the development of a first model. The model consists of a central station that transmits coded information via radio link to an on-body (i.e., worn on the wrist) receiving unit, the output from which is a coded vibrotactile signal. The model is a combination of commercially available equipment, customized electronic circuits, and electromechanical transducers. The paging system facilitates communication to deaf-blind clients in an institutional environment as an aid in their training and other activities. Several subunits of the system were individually developed, tested, and integrated into an operating system ready for experimentation and evaluation. The operation and characteristics of the system are described and photographs are shown.

  4. A membrane page composer - Further developments. [for holographic memory system

    NASA Technical Reports Server (NTRS)

    Cosentino, L. S.; Stewart, W. C.

    1974-01-01

    Membrane page composers were made and were evaluated in a simulated holographic optical memory system. Calculated and experimentally determined electromechanical and optical characteristics of the circular membrane light valves used on the arrays are shown to be in close agreement. Several operating prototypes of 8 x 8 and 16 x 16 elements were produced. Measurements were made of switching time, optical contrast, and dynamic storage time of many cells on the devices. Digital patterns were stored in the arrays. The performance required of the page composer as a component of an optical memory system is considered. The fabrication techniques used can be easily extended to larger arrays.

  5. Identification of Malicious Web Pages by Inductive Learning

    NASA Astrophysics Data System (ADS)

    Liu, Peishun; Wang, Xuefang

    Malicious web pages are an increasing threat to current computer systems in recent years. Traditional anti-virus techniques focus typically on detection of the static signatures of Malware and are ineffective against these new threats because they cannot deal with zero-day attacks. In this paper, a novel classification method for detecting malicious web pages is presented. This method is generalization and specialization of attack pattern based on inductive learning, which can be used for updating and expanding knowledge database. The attack pattern is established from an example and generalized by inductive learning, which can be used to detect unknown attacks whose behavior is similar to the example.

  6. Sterically hindered carboxylate ligands support water-bridged dimetallic centers that model features of metallohydrolase active sites.

    PubMed

    Lee, Dongwhan; Hung, Pei-Lin; Spingler, Bernhard; Lippard, Stephen J

    2002-02-11

    The synthesis and characterization of carboxylate-bridged dimetallic complexes are described. By using m-terphenyl-derived carboxylate ligands, a series of dicobalt(II), dicobalt(III), dinickel(II), and dizinc(II) complexes were synthesized. The compounds are [Co(2)(mu-O(2)CAr(Tol))(2)(O(2)CAr(Tol))(2)L(2)] (1), [Co(2)(mu-OH(2))(2)(mu-O(2)CAr(Tol))(2)(O(2)CAr(Tol))(2)L(2)] (2a-c), [Co(2)(mu-OH)(2)(mu-O(2)CAr(Tol))(2)(O(2)CAr(Tol))(2)L(2)] (3), [Ni(2)(mu-O(2)CAr(Tol))(4)L(2)] (4), [Ni(2)(mu-HO...H)(2)(mu-O(2)CAr(Tol))(2)(O(2)CAr(Tol))(2)L(2)] (5), and [Zn(2)(mu-O(2)CAr(Tol))(2)(O(2)CAr(Tol))(2)L(2)] (6), where Ar(Tol)CO(2)H = 2,6-di(p-tolyl)benzoic acid and L = pyridine, THF, or N,N-dibenzylethylenediamine. Structural analysis of these complexes revealed that additional bridging ligands can be readily accommodated within the [M(2)(mu-O(2)CAr(Tol))(2)](2+) core, allowing a wide distribution of M...M distances from 2.5745(6) to 4.0169(9) A. Unprecedented bridging units [M(2)(mu-OH(2))(2)(mu-O(2)CR)(2)](n+) and [M(2)(mu-HO...H)(2)(mu-O(2)CR)(2)](n+) were identified in 2a-c and 5, respectively, in which strong hydrogen bonding accommodates shifts of protons from bridging water molecules toward the dangling oxygen atoms of terminal monodentate carboxylate groups. Such a proton shift along the O...H...O coordinate attenuates the donor ability of the anionic carboxylate ligand, which can translate into increased Lewis acidity at the metal centers. Such double activation of bridging water molecules by a Lewis acidic metal center and a metal-bound general base may facilitate the reactivity of metallohydrolases such as methionine aminopeptidase (MAP). PMID:11825079

  7. Activated human mesenchymal stem/stromal cells suppress metastatic features of MDA-MB-231 cells by secreting IFN-β.

    PubMed

    Yoon, N; Park, M S; Shigemoto, T; Peltier, G; Lee, R H

    2016-01-01

    Our recent study showed that human mesenchymal stem/stromal cells (hMSCs) are activated to express tumor necrosis factor (TNF)-α-related apoptosis-inducing ligand (TRAIL) by exposure to TNF-α and these activated hMSCs effectively induce apoptosis in triple-negative breast cancer MDA-MB-231 (MDA) cells in vitro and in vivo. Here, we further demonstrated that activated hMSCs not only induced apoptosis of MDA cells but also reduced metastatic features in MDA cells. These activated hMSC-exposed MDA cells showed reduced tumorigenicity and suppressed formation of lung metastasis when implanted in the mammary fat pad. Surprisingly, the activated hMSC-exposed MDA cells increased TRAIL expression, resulting in apoptosis in MDA cells. Interestingly, upregulation of TRAIL in MDA cells was mediated by interferon-beta (IFN-β) secreted from activated hMSCs. Furthermore, IFN-β in activated hMSCs was induced by RNA and DNA released from apoptotic MDA cells in absent in melanoma 2 (AIM2) and IFN induced with helicase C domain 1 (IFIH1)-dependent manners. These observations were only seen in the TRAIL-sensitive breast cancer cell lines but not in the TRAIL-resistant breast cancer cell lines. Consistent with these results, Kaplan-Meier survival analysis also showed that lack of innate sensors detecting DNA or RNA is strongly associated with poor survival in estrogen receptor-negative breast cancer patients. In addition, cancer-associated fibroblasts (CAF) isolated from a breast cancer patient were also able to express TRAIL and IFN-β upon DNA and RNA stimulation. Therefore, our results suggest that the crosstalk between TRAIL-sensitive cancer cells and stromal cells creates a tumor-suppressive microenvironment and further provide a novel therapeutic approach to target stromal cells within cancer microenvironment for TRAIL sensitive cancer treatment. PMID:27077807

  8. Activated human mesenchymal stem/stromal cells suppress metastatic features of MDA-MB-231 cells by secreting IFN-β

    PubMed Central

    Yoon, N; Park, M S; Shigemoto, T; Peltier, G; Lee, R H

    2016-01-01

    Our recent study showed that human mesenchymal stem/stromal cells (hMSCs) are activated to express tumor necrosis factor (TNF)-α-related apoptosis-inducing ligand (TRAIL) by exposure to TNF-α and these activated hMSCs effectively induce apoptosis in triple-negative breast cancer MDA-MB-231 (MDA) cells in vitro and in vivo. Here, we further demonstrated that activated hMSCs not only induced apoptosis of MDA cells but also reduced metastatic features in MDA cells. These activated hMSC-exposed MDA cells showed reduced tumorigenicity and suppressed formation of lung metastasis when implanted in the mammary fat pad. Surprisingly, the activated hMSC-exposed MDA cells increased TRAIL expression, resulting in apoptosis in MDA cells. Interestingly, upregulation of TRAIL in MDA cells was mediated by interferon-beta (IFN-β) secreted from activated hMSCs. Furthermore, IFN-β in activated hMSCs was induced by RNA and DNA released from apoptotic MDA cells in absent in melanoma 2 (AIM2) and IFN induced with helicase C domain 1 (IFIH1)-dependent manners. These observations were only seen in the TRAIL-sensitive breast cancer cell lines but not in the TRAIL-resistant breast cancer cell lines. Consistent with these results, Kaplan–Meier survival analysis also showed that lack of innate sensors detecting DNA or RNA is strongly associated with poor survival in estrogen receptor-negative breast cancer patients. In addition, cancer-associated fibroblasts (CAF) isolated from a breast cancer patient were also able to express TRAIL and IFN-β upon DNA and RNA stimulation. Therefore, our results suggest that the crosstalk between TRAIL-sensitive cancer cells and stromal cells creates a tumor-suppressive microenvironment and further provide a novel therapeutic approach to target stromal cells within cancer microenvironment for TRAIL sensitive cancer treatment. PMID:27077807

  9. Let's Meet Famous Women Artists. A Creative Art Activity Book. A Teacher's Guide Featuring 19 Famous Women Artists' Biographies and Enrichment/Research Activities.

    ERIC Educational Resources Information Center

    Badman, Jacqueline; Lewis-Spicer, Lisa

    This activity guide showcases the work of 19 women artists who have made outstanding contributions to the world of art in spite of the incredible obstacles society placed upon them. Artists, alphabetically presented, include: Sofonisba Anguissola, Rosa Bonheur, Deborah Butterfield, Rosalba Carriera, Janet Fish, Helen Frankenthaler, Giovanna…

  10. Google's Web Page Ranking Applied to Different Topological Web Graph Structures.

    ERIC Educational Resources Information Center

    Meghabghab, George

    2001-01-01

    This research, part of the ongoing study to better understand Web page ranking on the Web, looks at a Web page as a graph structure or Web graph, and classifies different Web graphs in the new coordinate space (out-degree, in-degree). Google's Web ranking algorithm (Brin & Page, 1998) on ranking Web pages is applied in this new coordinate space.…

  11. 7 CFR 3402.11 - Proposal cover page.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Proposal cover page. 3402.11 Section 3402.11 Agriculture Regulations of the Department of Agriculture (Continued) COOPERATIVE STATE RESEARCH, EDUCATION, AND EXTENSION SERVICE, DEPARTMENT OF AGRICULTURE FOOD AND AGRICULTURAL SCIENCES NATIONAL...

  12. 7 CFR 3402.11 - Proposal cover page.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Proposal cover page. 3402.11 Section 3402.11 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE FOOD AND AGRICULTURAL SCIENCES NATIONAL NEEDS GRADUATE AND POSTGRADUATE FELLOWSHIP GRANTS...

  13. College of DuPage Student Portrait, Fall Quarter 1999.

    ERIC Educational Resources Information Center

    College of DuPage, Glen Ellyn, IL. Office of Research and Planning.

    The report profiles the College of DuPage's (COD) fall quarter 1999 student body. It presents a brief history of the college's enrollment and a comparison of enrollments with other Illinois community colleges. It also provides demographic information on current students. Additionally, enrollment information is included by program, division, and…

  14. Web Information Monitoring: An Analysis of Web Page Updates.

    ERIC Educational Resources Information Center

    Tan, Bing; Foo, Schubert; Hui, Siu Cheung

    2001-01-01

    Discusses the need for Web information mentoring systems that help users track and monitor Web information based on users' interests. Describes a study that analyzed Web pages, Web site domains and change frequency for a Web monitoring system developed at Nanyang Technological University (Singapore). (Author/LRW)

  15. Automatic Caption Localization for Photographs on World Wide Web Pages.

    ERIC Educational Resources Information Center

    Rowe, Neil C.; Frew, Brian

    1998-01-01

    Explores the indirect method of locating for indexing the likely explicit and implicit captions of photographs, using multimodal clues including the specific words used, syntax, surrounding layout of the Web page, and general appearance of the associated image. The MARIE-3 system thus avoids full image processing and full natural-language…

  16. Yellow-Page Services: Where are we Heading?

    NASA Astrophysics Data System (ADS)

    Heck, Andre

    1992-09-01

    Beyond purely scientific data, other kinds of information, not least useful and practical, are increasingly provided through networks of databases and archives. These "yellow-page services (YPS)" encompass bibliographic bases as well as directories. Thesauri, dictionaries of acronyms, libraries of software packages, sets of macros for electronic publishing are also rated as good complements.

  17. 48 CFR 1852.215-81 - Proposal page limitations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Proposal page limitations. 1852.215-81 Section 1852.215-81 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE... metric standard format most closely approximating the described standard 81/2″×11″ size may also be...

  18. 48 CFR 1852.215-81 - Proposal page limitations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Proposal page limitations. 1852.215-81 Section 1852.215-81 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE... metric standard format most closely approximating the described standard 81/2″×11″ size may also be...

  19. 22. PHOTOGRAPHIC ENLARGEMENT OF UPPER PHOTOGRAPH ON PAGE 986 IN ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    22. PHOTOGRAPHIC ENLARGEMENT OF UPPER PHOTOGRAPH ON PAGE 986 IN Keystone Coal Buyers Catalog, 1922, VIEW SOUTH, COMMUNITY OF ETHEL; ETHEL COAL COMPANY MINE SUPPLY BUILDING IS LOCATED IN MID-GROUND LEFT OF CENTER PARTIALLY OBSCURED BY ROOF OF HOUSE IN FOREGROUND - Ethel Coal Company & Supply Building, Left fork of Dingess Run (Ethel Hollow), Ethel, Logan County, WV

  20. 21. PHOTOGRAPH OF PAGE 986 IN Keystone Coal Buyers Catalog, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    21. PHOTOGRAPH OF PAGE 986 IN Keystone Coal Buyers Catalog, 1922, UPPER PHOTOGRAPH, VIEW SOUTH, COMMUNITY OF ETHEL; ETHEL COAL COMPANY MINE SUPPLY BUILDING IS LOCATED IN MID-GROUND LEFT OF CENTER PARTIALLY OBSCURED BY ROOF OF HOUSE IN FOREGROUND - Ethel Coal Company & Supply Building, Left fork of Dingess Run (Ethel Hollow), Ethel, Logan County, WV

  1. 23. PHOTOGRAPHIC ENLARGEMENT OF UPPER PHOTOGRAPH ON PAGE 986 IN ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    23. PHOTOGRAPHIC ENLARGEMENT OF UPPER PHOTOGRAPH ON PAGE 986 IN Keystone Coal Buyers Catalog, 1922, VIEW SOUTH, COMMUNITY OF ETHEL; ETHEL COAL COMPANY MINE SUPPLY BUILDING IS LOCATED IN MID-GROUND IN CENTER PARTIALLY OBSCURED BY ROOF OF HOUSE IN FOREGROUND - Ethel Coal Company & Supply Building, Left fork of Dingess Run (Ethel Hollow), Ethel, Logan County, WV

  2. 60. PAGE TWO OF PLANS FOR GRAND CANAL AT WASHINGTON ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    60. PAGE TWO OF PLANS FOR GRAND CANAL AT WASHINGTON STREET TIDEGATE SYSTEM REHABILITATION Plan Sheet D-28451, Sheet No. 2 of 3 (delineated by H. V. Nguyen, November 1985) - Venice Canals, Community of Venice, Los Angeles, Los Angeles County, CA

  3. 61. PAGE THREE OF PLANS FOR GRAND CANAL AT WASHINGTON ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    61. PAGE THREE OF PLANS FOR GRAND CANAL AT WASHINGTON STREET TIDEGATE SYSTEM REHABILITATION Plan Sheet D-28451, Sheet No. 3 of 3 (delineated by H. V. Nguyen, November 1985) - Venice Canals, Community of Venice, Los Angeles, Los Angeles County, CA

  4. Labels from the Electronic Yellow Pages: A BASIC Routine.

    ERIC Educational Resources Information Center

    Wismer, Donald

    1984-01-01

    Describes method of generating Electronic Yellow Pages mailing labels using DIALOG commands which involve downloading to disk and interposing a BASIC language program between disk and printer. Downloading problems (accession numbers, "tic" which DIALOG provides, line noise), two versions of program (full, compressed), and output examples are…

  5. What Should Be On A School Library Web Page?

    ERIC Educational Resources Information Center

    Baumbach, Donna; Brewer, Sally; Renfroe, Matt

    2004-01-01

    As varied as the schools and the communities they serve, so too are the Web pages for the library media programs that serve them. This article provides guidelines for effective web design and the information that might be included, including reference resources, reference asistance, curriculum support, literacy advocacy, and dynamic material. An…

  6. Exploring the Use of a Facebook Page in Anatomy Education

    ERIC Educational Resources Information Center

    Jaffar, Akram Abood

    2014-01-01

    Facebook is the most popular social media site visited by university students on a daily basis. Consequently, Facebook is the logical place to start with for integrating social media technologies into education. This study explores how a faculty-administered Facebook Page can be used to supplement anatomy education beyond the traditional…

  7. 8. Historic American Buildings Survey, From page 5, volume 26 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Historic American Buildings Survey, From page 5, volume 26 of the Castner Collection in the Print Room of the Free Library of Philadelphia, COPY OF c.1870 PHOTOGRAPH SHOWING NORTHEAST CORNER OF SIXTH AND ARCH STREETS-THE LEE HOUSE SIXTH FROM LEFT. - Robert M. Lee House & Law Office, 109-111 North Sixth Street, Philadelphia, Philadelphia County, PA

  8. 8. Historic American Buildings Survey, From page 18, volume 2 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Historic American Buildings Survey, From page 18, volume 2 of the Castner Collection in the Print Room of Free Library of Philadelphia, Logan Square. Negative is the gift of James F. O'Gorman COPY OF AN UNDATED DRAWING OF THE HALL VIEWED FROM NORTHEAST. - National Guard's Hall, 518-20 Race Street, Philadelphia, Philadelphia County, PA

  9. 36. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    36. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  10. 11. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  11. 29. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    29. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  12. 8. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  13. 24. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    24. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  14. 7. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  15. 25. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    25. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  16. 33. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    33. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  17. 22. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    22. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  18. 26. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    26. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  19. 10. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  20. 6. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  1. 3. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  2. 17. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    17. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  3. 34. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    34. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  4. 37. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    37. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  5. 38. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    38. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  6. 31. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    31. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  7. 20. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    20. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  8. 4. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  9. 15. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    15. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  10. 23. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    23. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  11. 12. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  12. 28. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    28. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  13. 19. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    19. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  14. 16. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  15. 21. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    21. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  16. 1. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  17. 13. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  18. 9. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  19. 5. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  20. 27. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    27. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  1. 30. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    30. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  2. 18. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    18. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  3. 39. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    39. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  4. 32. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    32. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  5. 35. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    35. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  6. 2. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  7. 14. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  8. 48 CFR 804.1102 - Vendor Information Pages (VIP) Database.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...://www.VetBiz.gov, and also must be registered in the Central Contractor Registration (CCR) (see 48 CFR... (VIP) Database. 804.1102 Section 804.1102 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS GENERAL ADMINISTRATIVE MATTERS Contract Execution 804.1102 Vendor Information Pages (VIP)...

  9. 48 CFR 804.1102 - Vendor Information Pages (VIP) Database.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...://www.VetBiz.gov, and also must be registered in the Central Contractor Registration (CCR) (see 48 CFR... (VIP) Database. 804.1102 Section 804.1102 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS GENERAL ADMINISTRATIVE MATTERS Contract Execution 804.1102 Vendor Information Pages (VIP)...

  10. 48 CFR 804.1102 - Vendor Information Pages (VIP) Database.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...://www.VetBiz.gov, and also must be registered in the Central Contractor Registration (CCR) (see 48 CFR... (VIP) Database. 804.1102 Section 804.1102 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS GENERAL ADMINISTRATIVE MATTERS Contract Execution 804.1102 Vendor Information Pages (VIP)...

  11. 48 CFR 804.1102 - Vendor Information Pages (VIP) Database.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...://www.VetBiz.gov, and also must be registered in the Central Contractor Registration (CCR) (see 48 CFR... (VIP) Database. 804.1102 Section 804.1102 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS GENERAL ADMINISTRATIVE MATTERS Contract Execution 804.1102 Vendor Information Pages (VIP)...

  12. 48 CFR 804.1102 - Vendor Information Pages (VIP) Database.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...://www.VetBiz.gov, and also must be registered in the Central Contractor Registration (CCR) (see 48 CFR... (VIP) Database. 804.1102 Section 804.1102 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS GENERAL ADMINISTRATIVE MATTERS Contract Execution 804.1102 Vendor Information Pages (VIP)...

  13. 7 CFR 3402.11 - Proposal cover page.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Proposal cover page. 3402.11 Section 3402.11 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE FOOD AND AGRICULTURAL SCIENCES NATIONAL NEEDS GRADUATE AND POSTGRADUATE FELLOWSHIP GRANTS...

  14. 7 CFR 3402.11 - Proposal cover page.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 15 2012-01-01 2012-01-01 false Proposal cover page. 3402.11 Section 3402.11 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE FOOD AND AGRICULTURAL SCIENCES NATIONAL NEEDS GRADUATE AND POSTGRADUATE FELLOWSHIP GRANTS...

  15. 105. Photocopy of plate opposite page 105 in Robert Dale ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    105. Photocopy of plate opposite page 105 in Robert Dale Owen, Hints on Public Architecture (New York, G. P. Putnam, 1849). GROUND-PLANS, SMITHSONIAN INSTITUTION - Smithsonian Institution Building, 1000 Jefferson Drive, between Ninth & Twelfth Streets, Southwest, Washington, District of Columbia, DC

  16. On Apples and Onions: A Reply to Page.

    ERIC Educational Resources Information Center

    Phillips, Gerald M.

    1980-01-01

    Answers some of William Page's criticisms (see preceding article, EJ 227 456) regarding the use of rhetoritherapy v behavior therapy to deal with students who exhibit communication apprehension. Argues that rhetoritherapy deals with people who have problems, not with problems. It is concerned with what can be done about the problem, not what the…

  17. The Inquiry Page: Bringing Digital Libraries to Learners.

    ERIC Educational Resources Information Center

    Bruce, Bertram C.; Bishop, Ann Peterson; Heidorn, P. Bryan; Lunsford, Karen J.; Poulakos, Steven; Won, Mihye

    2003-01-01

    Discusses digital library development, particularly a national science digital library, and describes the Inquiry Page which focuses on building a constructivist environment using Web resources, collaborative processes, and knowledge that bridges digital libraries with users in K-12 schools, museums, community groups, or other organizations. (LRW)

  18. 7 CFR 3402.11 - Proposal cover page.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Proposal cover page. 3402.11 Section 3402.11 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE FOOD AND AGRICULTURAL SCIENCES NATIONAL NEEDS GRADUATE AND POSTGRADUATE FELLOWSHIP GRANTS...

  19. Ranking nodes in growing networks: When PageRank fails

    PubMed Central

    Mariani, Manuel Sebastian; Medo, Matúš; Zhang, Yi-Cheng

    2015-01-01

    PageRank is arguably the most popular ranking algorithm which is being applied in real systems ranging from information to biological and infrastructure networks. Despite its outstanding popularity and broad use in different areas of science, the relation between the algorithm’s efficacy and properties of the network on which it acts has not yet been fully understood. We study here PageRank’s performance on a network model supported by real data, and show that realistic temporal effects make PageRank fail in individuating the most valuable nodes for a broad range of model parameters. Results on real data are in qualitative agreement with our model-based findings. This failure of PageRank reveals that the static approach to information filtering is inappropriate for a broad class of growing systems, and suggest that time-dependent algorithms that are based on the temporal linking patterns of these systems are needed to better rank the nodes. PMID:26553630

  20. Dynamic analysis of changing features of tumor cells incubated with antitumor agents in vitro and its application for predictive activity assay of antitumor agents.

    PubMed

    Oguro, M; Takagi, T; Takenaga, K

    1985-02-01

    Continuous observation of living malignant cells (L1210) in a specially devised glass observation chamber with an inverted microscope made it possible to classify various cellular morphological features induced by antitumor agents into the following four stages: 1) an initial stage consisting of cytoplasmic granulation and coloring, 2) an intermediate stage of shrinkage of nuclei, increases of vacuoles and cytoplasmic budding, 3) a determinate stage of cell ballooning and 4) the terminal stage (cell ghost). Both the initial and intermediate stages are characterized by cellular changes that appear at an early phase and remain opportunistic in terms of viability. Emergence of these cellular changes is largely dependent on the specific mode of action of antitumor agents. In contrast, definite irreversibility in the changes found in both the terminal and determinate stages was confirmed by continuous observation until the cells showed lytic or ghost features, using a video-recording system. A plot of the number of cells counted in both the determinate and terminal stages versus the time-dose schedule is designated as the "time-dose-response" plot, and this proved useful for estimating the characteristics of the antitumor agents tested and the actions of new antitumor agents on malignant cells (predictive activity assay graph). PMID:3920102

  1. Registered report: The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

    PubMed Central

    Fiehn, Oliver; Showalter, Megan Reed; Schaner-Tooley, Christine E

    2016-01-01

    The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by conducting replications of selected experiments from a number of high-profile papers in the field of cancer biology. The papers, which were published between 2010 and 2012, were selected on the basis of citations and Altmetric scores (Errington et al., 2014). This Registered Report describes the proposed replication plan of key experiments from “The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate” by Ward and colleagues, published in Cancer Cell in 2010 (Ward et al., 2010). The experiments that will be replicated are those reported in Figures 2, 3 and 5. Ward and colleagues demonstrate the mutations in isocitrate dehydrogenase 2 (IDH2), commonly found in acute myeloid leukemia (AML), abrogate the enzyme’s wild-type activity and confer to the mutant neomorphic activity that produces the oncometabolite 2-hydroxyglutarate (2-HG) (Figures 2 and 3). They then show that elevated levels of 2-HG are correlated with mutations in IDH1 and IDH2 in AML patient samples (Figure 5). The Reproducibility Project: Cancer Biology is a collaboration between the Center for Open Science and Science Exchange and the results of the replications will be published by eLife. DOI: http://dx.doi.org/10.7554/eLife.12626.001 PMID:26943899

  2. Novel derivatives of 1,3,4-oxadiazoles are potent mitostatic agents featuring strong microtubule depolymerizing activity in the sea urchin embryo and cell culture assays.

    PubMed

    Kiselyov, Alex S; Semenova, Marina N; Chernyshova, Natalya B; Leitao, Andrei; Samet, Alexandr V; Kislyi, Konstantine A; Raihstat, Mikhail M; Oprea, Tudor; Lemcke, Heiko; Lantow, Margaréta; Weiss, Dieter G; Ikizalp, Nazli N; Kuznetsov, Sergei A; Semenov, Victor V

    2010-05-01

    A series of novel 1,3,4-oxadiazole derivatives based on structural and electronic overlap with combretastatins have been designed and synthesized. Initially, we tested all new compounds in vivo using the phenotypic sea urchin embryo assay to yield a number of agents with anti-proliferative, anti-mitotic, and microtubule destabilizing activities. The experimental data led to identification of 1,3,4-oxadiazole derivatives with isothiazole (5-8) and phenyl (9-12) pharmacophores featuring activity profiles comparable to that of combretastatins, podophyllotoxin and nocodazole. Cytotoxic effects of the two lead molecules, namely 6 and 12, were further confirmed and evaluated by conventional assays with the A549 human cancer cell line including cell proliferation, cell cycle arrest at the G2/M phase, cellular microtubule distribution, and finally in vitro microtubule assembly with purified tubulin. The modeling results using 3D similarity (ROCS) and docking (FRED) correlated well with the observed activity of the molecules. Docking data suggested that the most potent molecules are likely to target the colchicine binding site. PMID:20110137

  3. Expression of FAP, ADAM12, WISP1, and SOX11 is heterogeneous in aggressive fibromatosis and spatially relates to the histologic features of tumor activity

    PubMed Central

    Misemer, Benjamin S; Skubitz, Amy P N; Carlos Manivel, J; Schmechel, Stephen C; Cheng, Edward Y; Henriksen, Jonathan C; Koopmeiners, Joseph S; Corless, Christopher L; Skubitz, Keith M

    2014-01-01

    Aggressive fibromatosis (AF) represents a group of tumors with a variable and unpredictable clinical course, characterized by a monoclonal proliferation of myofibroblastic cells. The optimal treatment for AF remains unclear. Identification and validation of genes whose expression patterns are associated with AF may elucidate biological mechanisms in AF, and aid treatment selection. This study was designed to examine the protein expression by immunohistochemistry (IHC) of four genes, ADAM12, FAP, SOX11, and WISP1, that were found in an earlier study to be uniquely overexpressed in AF compared with normal tissues. Digital image analysis was performed to evaluate inter- and intratumor heterogeneity, and correlate protein expression with histologic features, including a histopathologic assessment of tumor activity, defined by nuclear chromatin density ratio (CDR). AF tumors exhibited marked inter- and intratumor histologic heterogeneity. Pathologic assessment of tumor activity and digital assessment of average nuclear size and CDR were all significantly correlated. IHC revealed protein expression of all four genes. IHC staining for ADAM12, FAP, and WISP1 correlated with CDR and was higher, whereas SOX11 staining was lower in tumors with earlier recurrence following excision. All four proteins were expressed, and the regional variation in tumor activity within and among AF cases was demonstrated. A spatial correlation between protein expression and nuclear morphology was observed. IHC also correlated with the probability of recurrence following excision. These proteins may be involved in AF pathogenesis and the corresponding pathways could serve as potential targets of therapy. PMID:24402778

  4. Expression of FAP, ADAM12, WISP1, and SOX11 is heterogeneous in aggressive fibromatosis and spatially relates to the histologic features of tumor activity.

    PubMed

    Misemer, Benjamin S; Skubitz, Amy P N; Carlos Manivel, J; Schmechel, Stephen C; Cheng, Edward Y; Henriksen, Jonathan C; Koopmeiners, Joseph S; Corless, Christopher L; Skubitz, Keith M

    2014-02-01

    Aggressive fibromatosis (AF) represents a group of tumors with a variable and unpredictable clinical course, characterized by a monoclonal proliferation of myofibroblastic cells. The optimal treatment for AF remains unclear. Identification and validation of genes whose expression patterns are associated with AF may elucidate biological mechanisms in AF, and aid treatment selection. This study was designed to examine the protein expression by immunohistochemistry (IHC) of four genes, ADAM12, FAP, SOX11, and WISP1, that were found in an earlier study to be uniquely overexpressed in AF compared with normal tissues. Digital image analysis was performed to evaluate inter- and intratumor heterogeneity, and correlate protein expression with histologic features, including a histopathologic assessment of tumor activity, defined by nuclear chromatin density ratio (CDR). AF tumors exhibited marked inter- and intratumor histologic heterogeneity. Pathologic assessment of tumor activity and digital assessment of average nuclear size and CDR were all significantly correlated. IHC revealed protein expression of all four genes. IHC staining for ADAM12, FAP, and WISP1 correlated with CDR and was higher, whereas SOX11 staining was lower in tumors with earlier recurrence following excision. All four proteins were expressed, and the regional variation in tumor activity within and among AF cases was demonstrated. A spatial correlation between protein expression and nuclear morphology was observed. IHC also correlated with the probability of recurrence following excision. These proteins may be involved in AF pathogenesis and the corresponding pathways could serve as potential targets of therapy. PMID:24402778

  5. Video 3 of 8: Lesson Plan Feature on the Website

    NASA Video Gallery

    The Lesson Plan page provides lessons, activities and units. A search engine allows you to search by national standard, data or topics. These lesson plans engage students in science, technology, en...

  6. Activity, selectivity, and stereochemical features in the copper-catalyzed hydrogenative ring-opening of alkyl-substituted cyclopropanes - Nature of active sites

    SciTech Connect

    Palinko, I.; Molnar, A.; Kiss, J.T.; Bartok, M. )

    1990-02-01

    The reactions of four alkyl-substituted cyclopropanes in a hydrogen atmosphere in a closed circulation system have been studied over silica-supported and support-free copper catalysts made by different methods. Both isomerization and direct hydrogen addition occur. The ring opens in both the sterically more hindered and less hindered directions. On the basis of the kinetic data, mechanistic considerations are discussed. The catalysts were studied by N{sub 2}O titration and TPR (temperature-programmed reduction). The properties of the reactions and the TPR data indicate that the active centers are atomic clusters for the direct hydrogenation and Cu(I) ions for the ring-opening from the sterically hindered direction through the formation of olefinic compounds.

  7. The 2006-2007 Active Phase of Anomalous X-Ray Pulsar 4U 0142+61: Radiative and Timing Changes, Bursts,and Burst Spectral Features

    NASA Technical Reports Server (NTRS)

    Gavriil, Fotis P.; Dib, Rim; Kaspi, Victoria M.

    2011-01-01

    After at least 6 years of quiescence, Anomalous X-ray Pulsar (AXP) 4U 0142+61 entered an active phase in 2006 March that lasted several months and included six X-ray bursts as well as many changes in the persistent X-ray emission. The bursts, the first seen from this AXP in > 11 years of Rossi X-ray Timing Explorer monitoring, all occurred in the interval between 2006 April 6 and 2007 February 7. The burst durations ranged from 0.4 - 1.8 x 10(exp 3) s. The first five burst spectra are well modeled by blackbodies, with temperatures kT approx 2 - 9 keV. However, the sixth burst had a complicated spectrum that is well characterized by a blackbody plus two emission features whose amplitude varied throughout the burst. The most prominent feature was at 14.0 keV. Upon entry into the active phase the pulsar showed a significant change in pulse morphology and a likely timing glitch. The glitch had a total frequency jump of (1.9+/-0.4) x 10(exp -7) Hz, which recovered with a decay time of 17+/-2 days by more than the initial jump, implying a net spin-down of the pulsar. Within the framework of the magnetar model, the net spin-down of the star could be explained by regions of the superfluid that rotate. slower than the rest. The bursts, flux enhancements, and pulse morphology changes can be explained as arising from crustal deformations due to stresses imposed by the highly twisted internal magnetic field. However, unlike other AXP outbursts, we cannot account for a major twist being implanted in the magnetosphere.

  8. Feature- Spring 2010

    Cancer.gov

    NCI CAM News is a twice yearly newsletter produced by OCCAM to bring you information on the National Cancer Institute's latest CAM activities. Featured in the newsletter are: Highlights of NCI-sponsored CAM research Resources for researchers such as funding opportunities and grant writing workshops Upcoming meetings and lectures

  9. Feature Project--A Bright Idea.

    ERIC Educational Resources Information Center

    Tackabury, Pamela

    1985-01-01

    The teaching activities presented in this paper introduce elementary pupils to illuminated manuscripts of the Middle Ages, and, in doing so, integrate art and language and also provoke interest in history. The paper provides references, tells how to produce an illuminated calendar page (including getting background information on the history of…

  10. Google and the mind: predicting fluency with PageRank.

    PubMed

    Griffiths, Thomas L; Steyvers, Mark; Firl, Alana

    2007-12-01

    Human memory and Internet search engines face a shared computational problem, needing to retrieve stored pieces of information in response to a query. We explored whether they employ similar solutions, testing whether we could predict human performance on a fluency task using PageRank, a component of the Google search engine. In this task, people were shown a letter of the alphabet and asked to name the first word beginning with that letter that came to mind. We show that PageRank, computed on a semantic network constructed from word-association data, outperformed word frequency and the number of words for which a word is named as an associate as a predictor of the words that people produced in this task. We identify two simple process models that could support this apparent correspondence between human memory and Internet search, and relate our results to previous rational models of memory. PMID:18031414

  11. Automatic page composition with combined image crop and layout metrics

    NASA Astrophysics Data System (ADS)

    Hunter, Andrew; Greig, Darryl

    2012-03-01

    Automatic layout algorithms simplify the composition of image-rich documents, but they still require users to have sufficient artistry to supply well cropped and composed imagery. Combining an automatic cropping technology with a document layout system enables better results to be produced faster by less-skilled users. This paper reviews prior work in automatic image cropping and automatic page layout and presents a case for a combined crop and layout technology. We describe one such technology in a system for interactive publication design by amateur self-publishers and show that providing an automatic cropping system with additional information about the layout context can enable it to generate a more appropriate set of ranked crop options for a given image. Furthermore, we show that providing an automatic layout system with sets of ranked crop options for images can enable it to compose more appropriate page layouts.

  12. An adaptive replacement algorithm for paged-memory computer systems.

    NASA Technical Reports Server (NTRS)

    Thorington, J. M., Jr.; Irwin, J. D.

    1972-01-01

    A general class of adaptive replacement schemes for use in paged memories is developed. One such algorithm, called SIM, is simulated using a probability model that generates memory traces, and the results of the simulation of this adaptive scheme are compared with those obtained using the best nonlookahead algorithms. A technique for implementing this type of adaptive replacement algorithm with state of the art digital hardware is also presented.

  13. Error-correcting codes for page-oriented optical memories

    NASA Astrophysics Data System (ADS)

    Hutton, John F.; Betzos, George A.; Schaffer, Maureen E.; Mitkas, Pericles A.

    1996-11-01

    Parallel optical memories have been proposed to meet high speed, high capacity storage requirements for input/output intensive computer applications. This technology offers the capability for storage and retrieval of optical data in 2D pages resulting in high capacity and high throughput. CUrrent raw bit error rates of experimental systems fall significantly short of the minimum industry requirement of 10-12 for binary data. Thus, error control techniques for 2D data are necessary in order for such memories to be commercially feasible. In this paper, we discuss several error control schemes suitable for page- oriented data and specifically applicable to page-oriented optical memories. To better interface between the memory and the electronic host computer, we propose 'smart' photo- detector array devices in which the input is optical but the output is electronic. These arrays receive the optical signal form the memory and covert it to electronic data. Utilizing the speed of VLSI technology, the arrays perform fast parallel decoding and data correction, thereby providing an efficient optoelectronic interface between the memory and the electronic computer.

  14. Region-based Statistical Analysis of 2D PAGE Images

    PubMed Central

    Li, Feng; Seillier-Moiseiwitsch, Françoise; Korostyshevskiy, Valeriy R.

    2011-01-01

    A new comprehensive procedure for statistical analysis of two-dimensional polyacrylamide gel electrophoresis (2D PAGE) images is proposed, including protein region quantification, normalization and statistical analysis. Protein regions are defined by the master watershed map that is obtained from the mean gel. By working with these protein regions, the approach bypasses the current bottleneck in the analysis of 2D PAGE images: it does not require spot matching. Background correction is implemented in each protein region by local segmentation. Two-dimensional locally weighted smoothing (LOESS) is proposed to remove any systematic bias after quantification of protein regions. Proteins are separated into mutually independent sets based on detected correlations, and a multivariate analysis is used on each set to detect the group effect. A strategy for multiple hypothesis testing based on this multivariate approach combined with the usual Benjamini-Hochberg FDR procedure is formulated and applied to the differential analysis of 2D PAGE images. Each step in the analytical protocol is shown by using an actual dataset. The effectiveness of the proposed methodology is shown using simulated gels in comparison with the commercial software packages PDQuest and Dymension. We also introduce a new procedure for simulating gel images. PMID:21850152

  15. Adaptation of web pages and images for mobile applications

    NASA Astrophysics Data System (ADS)

    Kopf, Stephan; Guthier, Benjamin; Lemelson, Hendrik; Effelsberg, Wolfgang

    2009-02-01

    In this paper, we introduce our new visualization service which presents web pages and images on arbitrary devices with differing display resolutions. We analyze the layout of a web page and simplify its structure and formatting rules. The small screen of a mobile device is used much better this way. Our new image adaptation service combines several techniques. In a first step, border regions which do not contain relevant semantic content are identified. Cropping is used to remove these regions. Attention objects are identified in a second step. We use face detection, text detection and contrast based saliency maps to identify these objects and combine them into a region of interest. Optionally, the seam carving technique can be used to remove inner parts of an image. Additionally, we have developed a software tool to validate, add, delete, or modify all automatically extracted data. This tool also simulates different mobile devices, so that the user gets a feeling of how an adapted web page will look like. We have performed user studies to evaluate our web and image adaptation approach. Questions regarding software ergonomics, quality of the adapted content, and perceived benefit of the adaptation were asked.

  16. Using Firefly Tools to Enhance Archive Web Pages

    NASA Astrophysics Data System (ADS)

    Roby, W.; Wu, X.; Ly, L.; Goldina, T.

    2013-10-01

    Astronomy web developers are looking for fast and powerful HTML 5/AJAX tools to enhance their web archives. We are exploring ways to make this easier for the developer. How could you have a full FITS visualizer or a Web 2.0 table that supports paging, sorting, and filtering in your web page in 10 minutes? Can it be done without even installing any software or maintaining a server? Firefly is a powerful, configurable system for building web-based user interfaces to access astronomy science archives. It has been in production for the past three years. Recently, we have made some of the advanced components available through very simple JavaScript calls. This allows a web developer, without any significant knowledge of Firefly, to have FITS visualizers, advanced table display, and spectrum plots on their web pages with minimal learning curve. Because we use cross-site JSONP, installing a server is not necessary. Web sites that use these tools can be created in minutes. Firefly was created in IRSA, the NASA/IPAC Infrared Science Archive (http://irsa.ipac.caltech.edu). We are using Firefly to serve many projects including Spitzer, Planck, WISE, PTF, LSST and others.

  17. The Geological, Geomorphological Features and Kinematic Analysis of Active Faults Controlling Kemalpaşa Basin, Southwestern Part of Gediz Graben, Western Anatolia

    NASA Astrophysics Data System (ADS)

    Tepe, Çiǧdem; Sözbilir, Hasan

    2016-04-01

    The purpose of this study is to discuss the geological and geomorphological features of active faults controlling Kemalpaşa Basin. The study consists of basin-bounding faults expressions, kinematic and geomorphic analysis. Kemalpaşa Basin, which is approximately ENE trending and asymmetric graben is located in the southern part of Gediz Graben. Menderes Massif and Bornova Complex comprise the basement rocks of basin. Kızılca Formation, Sütçüler Formation and Alluvium uncomformably overlie the basement rocks. Kemalpaşa Basin which is one of the Quaternary basin in the Western Anatolia Extensional Province was developed at the structural border of the Spildaǧı Fault Zone in the north and the Kemalpaşa Fault in the south. Both the north and south margin-bounding faults of Kemalpaşa Basin are oblique-slip normal faults. According to the results of kinematic analysis, Kemalpaşa Basin has been formed under a NE-GW trending extensional tectonic regime. The variation in the relative degree of tectonic activity in Kemalpaşa Basin and its surroundings were interpreted a detailed geomorphic study of the fault-generated mountain fronts and drainage pattern of the both sides. To identify the impacts of active faults controlling the north and south margins of Kemalpaşa Basin on the geomorphological evolution, the geomorphic indices such as drainage basin geometries, triangular facets, axial river profiles have been determined and the degree of tectonic activity in the both sides of Kemalpaşa Basin has been numerically defined using morphometric indexes such as asymmetry factor (AF), hypsometric curve and integral (HI), valley floor width-to-height ratio (Vf) and mountain front sinuosity (Smf). In morphometric analysis, the both sides of the basin were investigated separating into two segments as the west and east. The values of HI (0,28-0,60), Vf (0,27-0,60) and Smf (1,3) calculated for the western part of the north margin compared with the values of HI (0

  18. Rich-club and page-club coefficients for directed graphs

    NASA Astrophysics Data System (ADS)

    Smilkov, Daniel; Kocarev, Ljupco

    2010-06-01

    Rich-club and page-club coefficients and their null models are introduced for directed graphs. Null models allow for a quantitative discussion of the rich-club and page-club phenomena. These coefficients are computed for four directed real-world networks: Arxiv High Energy Physics paper citation network, Web network (released from Google), Citation network among US Patents, and email network from a EU research institution. The results show a high correlation between rich-club and page-club ordering. For journal paper citation network, we identify both rich-club and page-club ordering, showing that “elite” papers are cited by other “elite” papers. Google web network shows partial rich-club and page-club ordering up to some point and then a narrow declining of the corresponding normalized coefficients, indicating the lack of rich-club ordering and the lack of page-club ordering, i.e. high in-degree (PageRank) pages purposely avoid sharing links with other high in-degree (PageRank) pages. For UC patents citation network, we identify page-club and rich-club ordering providing a conclusion that “elite” patents are cited by other “elite” patents. Finally, for email communication network we show lack of both rich-club and page-club ordering. We construct an example of synthetic network showing page-club ordering and the lack of rich-club ordering.

  19. XWRAPComposer: A Multi-Page Data Extraction Service for Bio-Computing Applications

    SciTech Connect

    Liu, L; Zhang, J; Han, W; Pu, C; Caverlee, J; Park, S; Critchlow, T; Coleman, M; Buttler, D

    2005-02-16

    This paper presents a service-oriented framework for the development of wrapper code generators, including the methodology of designing an effective wrapper program construction facility and a concrete implementation, called XWRAPComposer Three unique features distinguish XWRAPComposer from existing wrapper development approaches. First, XWRAPComposer is designed to enable multi-stage and multi-page data extraction. Second, XWRAPComposer is the only wrapper generation system that promotes the distinction of information extraction logic from query-answer control logic, allowing higher level of robustness against changes in the service provider's web site design or infrastructure. Third, XWRAPComposer provides a user-friendly plug-and-play interface, allowing seamless incorporation of external services and continuous changing service interfaces and data format.

  20. A small-scale hyperacute compound eye featuring active eye tremor: application to visual stabilization, target tracking, and short-range odometry.

    PubMed

    Colonnier, Fabien; Manecy, Augustin; Juston, Raphaël; Mallot, Hanspeter; Leitel, Robert; Floreano, Dario; Viollet, Stéphane

    2015-04-01

    In this study, a miniature artificial compound eye (15 mm in diameter) called the curved artificial compound eye (CurvACE) was endowed for the first time with hyperacuity, using similar micro-movements to those occurring in the fly's compound eye. A periodic micro-scanning movement of only a few degrees enables the vibrating compound eye to locate contrasting objects with a 40-fold greater resolution than that imposed by the interommatidial angle. In this study, we developed a new algorithm merging the output of 35 local processing units consisting of adjacent pairs of artificial ommatidia. The local measurements performed by each pair are processed in parallel with very few computational resources, which makes it possible to reach a high refresh rate of 500 Hz. An aerial robotic platform with two degrees of freedom equipped with the active CurvACE placed over naturally textured panels was able to assess its linear position accurately with respect to the environment thanks to its efficient gaze stabilization system. The algorithm was found to perform robustly at different light conditions as well as distance variations relative to the ground and featured small closed-loop positioning errors of the robot in the range of 45 mm. In addition, three tasks of interest were performed without having to change the algorithm: short-range odometry, visual stabilization, and tracking contrasting objects (hands) moving over a textured background. PMID:25712307

  1. H2 binding and splitting on a new-generation [FeFe]-hydrogenase model featuring a redox-active decamethylferrocenyl phosphine ligand: a theoretical investigation.

    PubMed

    Greco, Claudio

    2013-02-18

    [FeFe]-hydrogenases are dihydrogen-evolving metalloenzymes that are able to combine substrate binding and redox functionalities, a feature that has important bearing on their efficiency. New-generation bioinspired systems such as Fe(2)[(SCH(2))(2)NBn](CO)(3)(Cp*Fe(C(5)Me(4)CH(2)PEt(2)))(dppv) were shown to mimic H(2) oxidation and splitting processes performed by the [FeFe]-hydrogenase/ferredoxin system, and key mechanistic aspects of such reaction are theoretically investigated in the present contribution. We found that H(2) binding and heterolytic cleavage take place concomitantly on DFT models of the synthetic catalyst, due to a substrate-dependent intramolecular redox process that promotes dihydrogen activation. Therefore, formation of an iron-dihydrogen complex as a reaction intermediate is excluded in the biomimetic system, at variance with the case of the enzyme. H(2) uptake at the synthetic system also requires an energetically disfavored isomerization of the amine group acting as a base during splitting. A possible strategy to stabilize the conformation competent for H(2) binding is proposed, along with an analysis of the reactivity of a triiron complex in which di(thiomethyl)amine--the chelating group naturally occurring in [FeFe]-hydrogenases--substitutes the benzyl-containing dithiolate ligand. PMID:23374093

  2. MedlinePlus FAQ: Can you tell me how to cite MedlinePlus pages?

    MedlinePlus

    ... Here: Home → FAQs → Question URL of this page: https://www.nlm.nih.gov/medlineplus/faq/citation.html ... Aug 12; cited 2005 Aug 11]. Available from: https://www.nlm.nih.gov/medlineplus/. Health Topic page ...

  3. Business Systems Branch Abilities, Capabilities, and Services Web Page

    NASA Technical Reports Server (NTRS)

    Cortes-Pena, Aida Yoguely

    2009-01-01

    During the INSPIRE summer internship I acted as the Business Systems Branch Capability Owner for the Kennedy Web-based Initiative for Communicating Capabilities System (KWICC), with the responsibility of creating a portal that describes the services provided by this Branch. This project will help others achieve a clear view ofthe services that the Business System Branch provides to NASA and the Kennedy Space Center. After collecting the data through the interviews with subject matter experts and the literature in Business World and other web sites I identified discrepancies, made the necessary corrections to the sites and placed the information from the report into the KWICC web page.

  4. Children's recognition of advertisements on television and on Web pages.

    PubMed

    Blades, Mark; Oates, Caroline; Li, Shiying

    2013-03-01

    In this paper we consider the issue of advertising to children. Advertising to children raises a number of concerns, in particular the effects of food advertising on children's eating habits. We point out that virtually all the research into children's understanding of advertising has focused on traditional television advertisements, but much marketing aimed at children is now via the Internet and little is known about children's awareness of advertising on the Web. One important component of understanding advertisements is the ability to distinguish advertisements from other messages, and we suggest that young children's ability to recognise advertisements on a Web page is far behind their ability to recognise advertisements on television. PMID:22543303

  5. PageRank for low frequency earthquake detection

    NASA Astrophysics Data System (ADS)

    Aguiar, A. C.; Beroza, G. C.

    2013-12-01

    We have analyzed Hi-Net seismic waveform data during the April 2006 tremor episode in the Nankai Trough in SW Japan using the autocorrelation approach of Brown et al. (2008), which detects low frequency earthquakes (LFEs) based on pair-wise waveform matching. We have generalized this to exploit the fact that waveforms may repeat multiple times, on more than just a pair-wise basis. We are working towards developing a sound statistical basis for event detection, but that is complicated by two factors. First, the statistical behavior of the autocorrelations varies between stations. Analyzing one station at a time assures that the detection threshold will only depend on the station being analyzed. Second, the positive detections do not satisfy "closure." That is, if window A correlates with window B, and window B correlates with window C, then window A and window C do not necessarily correlate with one another. We want to evaluate whether or not a linked set of windows are correlated due to chance. To do this, we map our problem on to one that has previously been solved for web search, and apply Google's PageRank algorithm. PageRank is the probability of a 'random surfer' to visit a particular web page; it assigns a ranking for a webpage based on the amount of links associated with that page. For windows of seismic data instead of webpages, the windows with high probabilities suggest likely LFE signals. Once identified, we stack the matched windows to improve the snr and use these stacks as template signals to find other LFEs within continuous data. We compare the results among stations and declare a detection if they are found in a statistically significant number of stations, based on multinomial statistics. We compare our detections using the single-station method to detections found by Shelly et al. (2007) for the April 2006 tremor sequence in Shikoku, Japan. We find strong similarity between the results, as well as many new detections that were not found using

  6. NUCLEAR STRUCTURE AND DECAY DATA: INTRODUCTION TO RELEVANT WEB PAGES.

    SciTech Connect

    BURROWS, T.W.; MCLAUGHLIN, P.D.; NICHOLS, A.L.

    2005-04-04

    A brief description is given of the nuclear data centers around the world able to provide access to those databases and programs of highest relevance to nuclear structure and decay data specialists. A number of Web-page addresses are also provided for the reader to inspect and investigate these data and codes for study, evaluation and calculation. These instructions are not meant to be comprehensive, but should provide the reader with a reasonable means of electronic access to the most important data sets and programs.

  7. Photocopy of copy of blueprint between pages 151 and 152 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of copy of blueprint between pages 151 and 152 in completion report and history of the U.S.A. General hospital no. 21, compiled and edited under the direction of Major W.J. Cameron, by T.R. Wieger, Chief Engineer. The report was dated April 1, 1919. A copy of the report (4003/14/29) is at the National Archives, military records (floor 13 W), Washington, D.C. - Fitzsimons General Hospital, Bounded by East Colfax to south, Peoria Street to west, Denver City/County & Adams County Line to north, & U.S. Route 255 to east, Aurora, Adams County, CO

  8. Do-It-Yourself: A Special Library's Approach to Creating Dynamic Web Pages Using Commercial Off-The-Shelf Applications

    NASA Technical Reports Server (NTRS)

    Steeman, Gerald; Connell, Christopher

    2000-01-01

    Many librarians may feel that dynamic Web pages are out of their reach, financially and technically. Yet we are reminded in library and Web design literature that static home pages are a thing of the past. This paper describes how librarians at the Institute for Defense Analyses (IDA) library developed a database-driven, dynamic intranet site using commercial off-the-shelf applications. Administrative issues include surveying a library users group for interest and needs evaluation; outlining metadata elements; and, committing resources from managing time to populate the database and training in Microsoft FrontPage and Web-to-database design. Technical issues covered include Microsoft Access database fundamentals, lessons learned in the Web-to-database process (including setting up Database Source Names (DSNs), redesigning queries to accommodate the Web interface, and understanding Access 97 query language vs. Standard Query Language (SQL)). This paper also offers tips on editing Active Server Pages (ASP) scripting to create desired results. A how-to annotated resource list closes out the paper.

  9. Using Facebook Page Insights Data to Determine Posting Best Practices in an Academic Health Sciences Library

    ERIC Educational Resources Information Center

    Houk, Kathryn M.; Thornhill, Kate

    2013-01-01

    Tufts University Hirsh Health Sciences Library created a Facebook page and a corresponding managing committee in March 2010. Facebook Page Insights data collected from the library's Facebook page were statistically analyzed to investigate patterns of user engagement. The committee hoped to improve posting practices and increase user…

  10. Forum Page Letters in the "Straits Times" of Singapore during Relatively Free and Restricted Press Periods.

    ERIC Educational Resources Information Center

    Ramaprasad, Jyotika; Ong, James

    In order to identify the scope or limits of the practice of development journalism, a study examined the content of the Forum page in the "Straits Times" of Singapore during relatively free (1979-1980) and restricted (1986-1987) press periods. The study had two major objectives: (1) to study the nature of the Forum page (a readers' letter page in…

  11. 47 CFR 22.529 - Application requirements for the Paging and Radiotelephone Service.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 2 2012-10-01 2012-10-01 false Application requirements for the Paging and Radiotelephone Service. 22.529 Section 22.529 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES PUBLIC MOBILE SERVICES Paging and Radiotelephone Service § 22.529 Application requirements for the Paging...

  12. 78 FR 22937 - 60-Day Notice of Proposed Information Collection: Application for Additional Visa Pages or...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-17

    ... to general format changes, the following content changes have been made to the form. Page 1 Form...'' and the words ``Duration of Trip'' have been replaced with ``Return Date''. Page 1 Form--In the first... ``Signature''. Page 1 Form--The second signature block ``Parent's/Legal Guardian's Signature (if...

  13. 78 FR 44424 - Revisions to Page 700 of FERC Form No. 6

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-24

    ... rate base, and income taxes reported on Page 700. \\8\\ Revisions to Page 700 of FERC Form No. 6, 77 FR... (Commission) is modifying Page 700 of FERC Form No. 6 (Form 6) to facilitate the calculation of an oil.... NOPR 22 2. Comments 24 3. Commission Determination 26 E. Calculation of Actual Rate of Return on...

  14. 14 CFR 389.26 - Special rules for tariff page filings.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Special rules for tariff page filings. 389... § 389.26 Special rules for tariff page filings. (a) Tariffs issued by carriers. The filing fee for tariff pages filed by U.S. air carriers will be charged even if the tariff includes matters...

  15. MedlinePlus FAQ: What's New on Medline Plus Page and Email Updates

    MedlinePlus

    ... faq/whatsnew.html Question: How is the What's New on MedlinePlus page and RSS feed different from ... this page, please enable JavaScript. Answer: The What's New on MedlinePlus page and RSS feed include alerts ...

  16. Young children's ability to recognize advertisements in web page designs.

    PubMed

    Ali, Moondore; Blades, Mark; Oates, Caroline; Blumberg, Fran

    2009-03-01

    Identifying what is, and what is not an advertisement is the first step in realizing that an advertisement is a marketing message. Children can distinguish television advertisements from programmes by about 5 years of age. Although previous researchers have investigated television advertising, little attention has been given to advertisements in other media, even though other media, especially the Internet, have become important channels of marketing to children. We showed children printed copies of invented web pages that included advertisements, half of which had price information, and asked the children to point to whatever they thought was an advertisement. In two experiments we tested a total of 401 children, aged 6, 8, 10 and 12 years of age, from the United Kingdom and Indonesia. Six-year-olds recognized a quarter of the advertisements, 8-year-olds recognized half the advertisements, and the 10- and 12-year-olds recognized about three-quarters. Only the 10- and 12-year-olds were more likely to identify an advertisement when it included a price. We contrast our findings with previous results about the identification of television advertising, and discuss why children were poorer at recognizing web page advertisements. The performance of the children has implications for theories about how children develop an understanding of advertising. PMID:19972663

  17. How Much Information Do Search Engines Disclose on the Links to a Web Page? A Longitudinal Case Study of the "Cybermetrics" Home Page.

    ERIC Educational Resources Information Center

    Bar-Ilan, Judit

    2002-01-01

    Discussion of bibliometric studies on the World Wide Web focuses on results of a search for links to the home page of the electronic journal "Cybermetrics". Presents results of a content analysis that showed search engines do not retrieve all the link pages that are indexed by them. (Author/LRW)

  18. Credibility judgments in web page design - a brief review.

    PubMed

    Selejan, O; Muresanu, D F; Popa, L; Muresanu-Oloeriu, I; Iudean, D; Buzoianu, A; Suciu, S

    2016-01-01

    Today, more than ever, knowledge that interfaces appearance analysis is a crucial point in human-computer interaction field has been accepted. As nowadays virtually anyone can publish information on the web, the credibility role has grown increasingly important in relation to the web-based content. Areas like trust, credibility, and behavior, doubled by overall impression and user expectation are today in the spotlight of research compared to the last period, when other pragmatic areas such as usability and utility were considered. Credibility has been discussed as a theoretical construct in the field of communication in the past decades and revealed that people tend to evaluate the credibility of communication primarily by the communicator's expertise. Other factors involved in the content communication process are trustworthiness and dynamism as well as various other criteria but to a lower extent. In this brief review, factors like web page aesthetics, browsing experiences and user experience are considered. PMID:27453738

  19. Purification of DNA Oligos by denaturing polyacrylamide gel electrophoresis (PAGE).

    PubMed

    Lopez-Gomollon, Sara; Nicolas, Francisco Esteban

    2013-01-01

    After chemical synthesis, the oligonucleotide preparation contains the desired full-length oligonucleotide but also all of the DNA molecules that were aborted during each cycle in the synthesis, and the by-products generated during the chemical reactions. The purification of oligonucleotides is a critical step for demanding applications where the exact length or sequence of the oligonucleotide is important, or for oligonucleotides longer than 50 bases. There are several methods of increasing oligonucleotide purity, the choice of which will depend on modifications of the oligonucleotides and their intended use. Polyacrylamide gel purification (PAGE purification) is the method of choice when the highest percentage of full-length oligonucleotide is desired. This chapter describes a protocol for oligonucleotide purification using denaturing polyacrylamide gel electrophoresis, and includes oligonucleotide preparation, polyacrylamide gel electrophoresis, and purification from the gel slice by two different methods: by diffusion or by electroelution. This chapter also includes recommendations as well as protocol advice. PMID:24011037

  20. Learning Layouts for Single-Page Graphic Designs.

    PubMed

    O'Donovan, Peter; Agarwala, Aseem; Hertzmann, Aaron

    2014-08-01

    This paper presents an approach for automatically creating graphic design layouts using a new energy-based model derived from design principles. The model includes several new algorithms for analyzing graphic designs, including the prediction of perceived importance, alignment detection, and hierarchical segmentation. Given the model, we use optimization to synthesize new layouts for a variety of single-page graphic designs. Model parameters are learned with Nonlinear Inverse Optimization (NIO) from a small number of example layouts. To demonstrate our approach, we show results for applications including generating design layouts in various styles, retargeting designs to new sizes, and improving existing designs. We also compare our automatic results with designs created using crowdsourcing and show that our approach performs slightly better than novice designers. PMID:26357371

  1. Hawking-Page phase transition in new massive gravity

    NASA Astrophysics Data System (ADS)

    Zhang, Shao-Jun

    2015-07-01

    We consider Hawking-Page phase transition between the BTZ black hole with M ≥ 0 and the thermal soliton with M = - 1 in new massive gravity. By comparing the on-shell free energies, we can see that there exists a critical temperature. The thermal soliton is more probable than the black hole below the critical temperature while the black hole is more probable than the thermal soliton above the critical temperature. By consistently constructing the off-shell free energies taking into account the conical singularity, we show that there exist infinite non-equilibrium states connecting the BTZ black hole and the thermal soliton, so that they provide a picture of continuous evolution of the phase transition.

  2. Intelligent Paging Based Mobile User Tracking Using Fuzzy Logic

    NASA Astrophysics Data System (ADS)

    Saha, Sajal; Dutta, Raju; Debnath, Soumen; Mukhopadhyay, Asish K.

    2010-11-01

    In general, a mobile user travels in a predefined path that depends mostly on the user's characteristics. Thus, tracking the locations of a mobile user is one of the challenges for location management. In this paper, we introduce a movement pattern learning strategy system to track the user's movements using adaptive fuzzy logic. Our fuzzy inference system extracts patterns from the historical data record of the cell numbers along with the date and time stamp of the users occupying the cell. Implementation of this strategy has been evaluated with the real time user data which proves the efficiency and accuracy of the model. This mechanism not only reduces user location tracking costs, but also significantly decreases the call-loss rates and average paging delays.

  3. Credibility judgments in web page design – a brief review

    PubMed Central

    Selejan, O; Muresanu, DF; Popa, L; Muresanu-Oloeriu, I; Iudean, D; Buzoianu, A; Suciu, S

    2016-01-01

    Today, more than ever, knowledge that interfaces appearance analysis is a crucial point in human-computer interaction field has been accepted. As nowadays virtually anyone can publish information on the web, the credibility role has grown increasingly important in relation to the web-based content. Areas like trust, credibility, and behavior, doubled by overall impression and user expectation are today in the spotlight of research compared to the last period, when other pragmatic areas such as usability and utility were considered. Credibility has been discussed as a theoretical construct in the field of communication in the past decades and revealed that people tend to evaluate the credibility of communication primarily by the communicator’s expertise. Other factors involved in the content communication process are trustworthiness and dynamism as well as various other criteria but to a lower extent. In this brief review, factors like web page aesthetics, browsing experiences and user experience are considered. PMID:27453738

  4. Henry Hutchinson Stewart (1798-1879): from page to philanthropist.

    PubMed

    Breathnach, C S

    1998-03-01

    Henry Hutchinson Stewart [1798-1879] began life as a page to the Vice-Reine and came to the study of medicine rather belatedly. After some years in general practice he was appointed Governor to the Hospitals of the Houses of Industry in Dublin. In 1856 he was responsible for the removal of forgotten, friendless mental patients from the Houses of Industry to a disused hotel at Lucan outside the city. Later on, when a committee proposed to provide a training institution for the menatlly handicapped, he handed over his premises in Lucan to them with its annual income in addition to a donation. In his will he bequeathed further substantial sums to the Institution which still bears his name, and money was also made available to the Irish Universities to found valuable scholarships. PMID:11620006

  5. To Overcome HITS Rank Similarity Confliction of Web Pages using Weight Calculation and Rank Improvement

    NASA Astrophysics Data System (ADS)

    Nath, Rajender; Kumar, Naresh

    2011-12-01

    Search Engine gives an ordered list of web search results in response to a user query, wherein the important pages are usually displayed at the top with less important ones afterwards. It may be possible that the user may have to look for many screen results to get the required documents. In literatures, many page ranking algorithms has been given to find the page rank of a page. For example PageRank is considered in this work. This algorithm treats all the links equally when distributing rank scores. That's why this algorithm some time gives equal importance to all the pages. But in real this can not be happen because, if two pages have same rank then how we can judge which page is more important then other. So this paper proposes another idea to organize the search results and describe which page is more important when confliction of same rank is produced by the PageRank. So that the user can get more relevant and important results easily and in a short span of time.

  6. Semantic Feature Distinctiveness and Frequency

    ERIC Educational Resources Information Center

    Lamb, Katherine M.

    2012-01-01

    Lexical access is the process in which basic components of meaning in language, the lexical entries (words) are activated. This activation is based on the organization and representational structure of the lexical entries. Semantic features of words, which are the prominent semantic characteristics of a word concept, provide important information…

  7. "Spacecraft Reveals Recent Geological Activity on the Moon": Exploring the Features of NASA Twitter Posts and Their Potential to Engage Adolescents

    ERIC Educational Resources Information Center

    Lesley, Mellinee

    2014-01-01

    Through a content analysis of 200 "tweets," this study was an exploration into the distinct features of text posted to NASA's "Twitter" site and the potential for these posts to serve as more engaging scientific text than traditional textbooks for adolescents. Results of the content analysis indicated the tweets and linked…

  8. NIAMS Kids Pages on Muscles, Joints, Skin and Bones

    MedlinePlus

    ... that will help you keep your bones, joints, muscles, and skin healthy for years to come. Have ... back often for updates and new features. Healthy Muscles Matter Healthy Skin Matters Healthy Joints Matter Healthy ...

  9. Socorro Students Translate NRAO Web Pages Into Spanish

    NASA Astrophysics Data System (ADS)

    2002-07-01

    Six Socorro High School students are spending their summer working at the National Radio Astronomy Observatory (NRAO) on a unique project that gives them experience in language translation, World Wide Web design, and technical communication. Under the project, called "Un puente a los cielos," the students are translating many of NRAO's Web pages on astronomy into Spanish. "These students are using their bilingual skills to help us make basic information about astronomy and radio telescopes available to the Spanish-speaking community," said Kristy Dyer, who works at NRAO as a National Science Foundation postdoctoral fellow and who developed the project and obtained funding for it from the National Aeronautics and Space Administration. The students are: Daniel Acosta, 16; Rossellys Amarante, 15; Sandra Cano, 16; Joel Gonzalez, 16; Angelica Hernandez, 16; and Cecilia Lopez, 16. The translation project, a joint effort of NRAO and the NM Tech physics department, also includes Zammaya Moreno, a teacher from Ecuador, Robyn Harrison, NRAO's education officer, and NRAO computer specialist Allan Poindexter. The students are translating NRAO Web pages aimed at the general public. These pages cover the basics of radio astronomy and frequently-asked questions about NRAO and the scientific research done with NRAO's telescopes. "Writing about science for non-technical audiences has to be done carefully. Scientific concepts must be presented in terms that are understandable to non-scientists but also that remain scientifically accurate," Dyer said. "When translating this type of writing from one language to another, we need to preserve both the understandability and the accuracy," she added. For that reason, Dyer recruited 14 Spanish-speaking astronomers from Argentina, Mexico and the U.S. to help verify the scientific accuracy of the Spanish translations. The astronomers will review the translations. The project is giving the students a broad range of experience. "They are

  10. Features of Jupiter's Great Red Spot

    NASA Technical Reports Server (NTRS)

    1996-01-01

    This montage features activity in the turbulent region of Jupiter's Great Red Spot (GRS). Four sets of images of the GRS were taken through various filters of the Galileo imaging system over an 11.5 hour period on 26 June, 1996 Universal Time. The sequence was designed to reveal cloud motions. The top and bottom frames on the left are of the same area, northeast of the GRS, viewed through the methane (732 nm) filter but about 70 minutes apart. The top left and top middle frames are of the same area and at the same time, but the top middle frame is taken at a wavelength (886 nm) where methane absorbs more strongly. (Only high clouds can reflect sunlight in this wavelength.) Brightness differences are caused by the different depths of features in the two images. The bottom middle frame shows reflected light at a wavelength (757 nm) where there are essentially no absorbers in the Jovian atmosphere. The white spot is to the northwest of the GRS; its appearance at different wavelengths suggests that the brightest elements are 30 km higher than the surrounding clouds. The top and bottom frames on the right, taken nine hours apart and in the violet (415 nm) filter, show the time evolution of an atmospheric wave northeast of the GRS. Visible crests in the top right frame are much less apparent 9 hours later in the bottom right frame. The misalignment of the north-south wave crests with the observed northwestward local wind may indicate a shift in wind direction (wind shear) with height. The areas within the dark lines are 'truth windows' or sections of the images which were transmitted to Earth using less data compression. Each of the six squares covers 4.8 degrees of latitude and longitude (about 6000 square kilometers). North is at the top of each frame.

    Launched in October 1989, Galileo entered orbit around Jupiter on December 7, 1995. The spacecraft's mission is to conduct detailed studies of the giant planet, its largest moons and the Jovian magnetic environment

  11. Transfer Learning across Feature-Rich Heterogeneous Feature Spaces via Feature-Space Remapping (FSR)

    PubMed Central

    Feuz, Kyle D.; Cook, Diane J.

    2016-01-01

    Transfer learning aims to improve performance on a target task by utilizing previous knowledge learned from source tasks. In this paper we introduce a novel heterogeneous transfer learning technique, Feature- Space Remapping (FSR), which transfers knowledge between domains with different feature spaces. This is accomplished without requiring typical feature-feature, feature instance, or instance-instance co-occurrence data. Instead we relate features in different feature-spaces through the construction of meta-features. We show how these techniques can utilize multiple source datasets to construct an ensemble learner which further improves performance. We apply FSR to an activity recognition problem and a document classification problem. The ensemble technique is able to outperform all other baselines and even performs better than a classifier trained using a large amount of labeled data in the target domain. These problems are especially difficult because in addition to having different feature-spaces, the marginal probability distributions and the class labels are also different. This work extends the state of the art in transfer learning by considering large transfer across dramatically different spaces. PMID:27019767

  12. PAGES-Powell North America 2k database

    NASA Astrophysics Data System (ADS)

    McKay, N.

    2014-12-01

    Syntheses of paleoclimate data in North America are essential for understanding long-term spatiotemporal variability in climate and for properly assessing risk on decadal and longer timescales. Existing reconstructions of the past 2,000 years rely almost exclusively on tree-ring records, which can underestimate low-frequency variability and rarely extend beyond the last millennium. Meanwhile, many records from the full spectrum of paleoclimate archives are available and hold the potential of enhancing our understanding of past climate across North America over the past 2000 years. The second phase of the Past Global Changes (PAGES) North America 2k project began in 2014, with a primary goal of assembling these disparate paleoclimate records into a unified database. This effort is currently supported by the USGS Powell Center together with PAGES. Its success requires grassroots support from the community of researchers developing and interpreting paleoclimatic evidence relevant to the past 2000 years. Most likely, fewer than half of the published records appropriate for this database are publicly archived, and far fewer include the data needed to quantify geochronologic uncertainty, or to concisely describe how best to interpret the data in context of a large-scale paleoclimatic synthesis. The current version of the database includes records that (1) have been published in a peer-reviewed journal (including evidence of the record's relationship to climate), (2) cover a substantial portion of the past 2000 yr (>300 yr for annual records, >500 yr for lower frequency records) at relatively high resolution (<50 yr/observation), and (3) have reasonably small and quantifiable age uncertainty. Presently, the database includes records from boreholes, ice cores, lake and marine sediments, speleothems, and tree rings. This poster presentation will display the site locations and basic metadata of the records currently in the database. We invite anyone with interest in

  13. What I Need to Know about Physical Activity and Diabetes

    MedlinePlus

    ... Association of Diabetes Educators American Diabetes Association JDRF Diabetes Disease Organizations Many organizations provide support to patients ... I need to know about Physical Activity and Diabetes Page Content On this page: How can physical ...

  14. A biplex approach to PageRank centrality: From classic to multiplex networks.

    PubMed

    Pedroche, Francisco; Romance, Miguel; Criado, Regino

    2016-06-01

    In this paper, we present a new view of the PageRank algorithm inspired by multiplex networks. This new approach allows to introduce a new centrality measure for classic complex networks and a new proposal to extend the usual PageRank algorithm to multiplex networks. We give some analytical relations between these new approaches and the classic PageRank centrality measure, and we illustrate the new parameters presented by computing them on real underground networks. PMID:27368791

  15. A biplex approach to PageRank centrality: From classic to multiplex networks

    NASA Astrophysics Data System (ADS)

    Pedroche, Francisco; Romance, Miguel; Criado, Regino

    2016-06-01

    In this paper, we present a new view of the PageRank algorithm inspired by multiplex networks. This new approach allows to introduce a new centrality measure for classic complex networks and a new proposal to extend the usual PageRank algorithm to multiplex networks. We give some analytical relations between these new approaches and the classic PageRank centrality measure, and we illustrate the new parameters presented by computing them on real underground networks.

  16. Design and implementation of a page-oriented "holographic" memory based on a Lippmann architecture.

    PubMed

    Contreras, Kevin; Pauliat, Gilles

    2011-10-20

    Optical data storage inspired by Lippmann interference color photography was proposed a long time ago as an alternative to holographic memories. Very high capacities were predicted for a page-oriented approach with wavelength multiplexing, but, up to now, such an architecture has never been implemented. Based on simple conception rules, we build such a page-oriented Lippmann data storage system. Submicrometer resolved data pages recorded in thick materials are evidenced by the experimental results. PMID:22015410

  17. Page segmentation using script identification vectors: A first look

    SciTech Connect

    Hochberg, J.; Cannon, M.; Kelly, P.; White, J.

    1997-07-01

    Document images in which different scripts, such as Chinese and Roman, appear on a single page pose a problem for optical character recognition (OCR) systems. This paper explores the use of script identification vectors in the analysis of multilingual document images. A script identification vector is calculated for each connected component in a document. The vector expresses the closest distance between the component and templates developed for each of thirteen scripts, including Arabic, Chinese, Cyrillic, and Roman. The authors calculate the first three principal components within the resulting thirteen-dimensional space for each image. By mapping these components to red, green, and blue, they can visualize the information contained in the script identification vectors. The visualization of several multilingual images suggests that the script identification vectors can be used to segment images into script-specific regions as large as several paragraphs or as small as a few characters. The visualized vectors also reveal distinctions within scripts, such as font in Roman documents, and kanji vs. kana in Japanese. Results are best for documents containing highly dissimilar scripts such as Roman and Japanese. Documents containing similar scripts, such as Roman and Cyrillic will require further investigation.

  18. Rotorcraft Aeromechanics Branch Home Page on the World Wide Web

    NASA Technical Reports Server (NTRS)

    Peterson, Randall L.; Warmbrodt, William (Technical Monitor)

    1996-01-01

    , strength, and location of the tip vortex, therefore changing the BVI acoustics of the rotor. The subwings are approximately 20% of the blade chord and increase the rotor radius by about 3 percent. Four different subwing configurations will be tested, including square tipped subwings with different angles of incidence. The ability of active controls to reduce BVI acoustics will also be assessed. The dynamic control system of the RTA will be used to implement open- and closed-loop active control techniques, including individual blade control. Open-loop testing will be conducted using a personal computer based, automated, real-time data acquisition system. This system features combined automated output of open loop control signals and automated data acquisition of the resulting test data. A final technique to alter the noise of the rotor will be examined. This will involve changing the number of blades from three to four. A four-bladed rotor hub has been fabricated on which the XV-15 blades will be mounted. While the solidity of the rotor will increase, much useful information can be gained by examining the changes in the thrust and RPM with four blades.

  19. Flood-inundation maps for the DuPage River from Plainfield to Shorewood, Illinois, 2013

    USGS Publications Warehouse

    Murphy, Elizabeth A.; Sharpe, Jennifer B.

    2013-01-01

    Digital flood-inundation maps for a 15.5-mi reach of the DuPage River from Plainfield to Shorewood, Illinois, were created by the U.S. Geological Survey (USGS) in cooperation with the Will County Stormwater Management Planning Committee. The inundation maps, which can be accessed through the USGS Flood Inundation Mapping Science Web site at http://water.usgs.gov/osw/flood_inundation/ depict estimates of the areal extent of flooding corresponding to selected water levels (gage heights or stages) at the USGS streamgage at DuPage River at Shorewood, Illinois (sta. no. 05540500). Current conditions at the USGS streamgage may be obtained on the Internet at http://waterdata.usgs.gov/usa/nwis/uv?05540500. In addition, the information has been provided to the National Weather Service (NWS) for incorporation into their Advanced Hydrologic Prediction Service (AHPS) flood warning system (http://water.weather.gov/ahps/). The NWS forecasts flood hydrographs at many places that are often colocated with USGS streamgages. The NWS-forecasted peak-stage information, also shown on the DuPage River at Shorewood inundation Web site, may be used in conjunction with the maps developed in this study to show predicted areas of flood inundation. In this study, flood profiles were computed for the stream reach by means of a one-dimensional step-backwater model. The hydraulic model was then used to determine nine water-surface profiles for flood stages at 1-ft intervals referenced to the streamgage datum and ranging from NWS Action stage of 6 ft to the historic crest of 14.0 ft. The simulated water-surface profiles were then combined with a Digital Elevation Model (DEM) (derived from Light Detection And Ranging (LiDAR) data) by using a Geographic Information System (GIS) in order to delineate the area flooded at each water level. These maps, along with information on the Internet regarding current gage height from USGS streamgages and forecasted stream stages from the NWS, provide emergency

  20. Basic features of low-temperature plasma formation in the course of composite coating synthesis at the active faces of complex contoured hard tools

    NASA Astrophysics Data System (ADS)

    Brzhozovsky, B. M.; Zimnyakov, D. A.; Zinina, E. P.; Martynov, V. V.; Pleshakova, E. S.; Yuvchenko, S. A.

    2016-04-01

    Basic features of combined-discharge low-temperature plasma formation around the surfaces of complex-contoured metal units are considered. It is shown that it makes the possibilities for synthesis of hardened high-durable coatings of hard tools appropriate for material processing in extreme load-temperature conditions. Experimental study of the coating formation was carried out in combination with the analysis of emission spectra of a low-temperature plasma cloud. Some practical examples of the coating applications are presented.