Science.gov

Sample records for activity page features

  1. An Ant Colony Optimization Based Feature Selection for Web Page Classification

    PubMed Central

    2014-01-01

    The increased popularity of the web has caused the inclusion of huge amount of information to the web, and as a result of this explosive information growth, automated web page classification systems are needed to improve search engines' performance. Web pages have a large number of features such as HTML/XML tags, URLs, hyperlinks, and text contents that should be considered during an automated classification process. The aim of this study is to reduce the number of features to be used to improve runtime and accuracy of the classification of web pages. In this study, we used an ant colony optimization (ACO) algorithm to select the best features, and then we applied the well-known C4.5, naive Bayes, and k nearest neighbor classifiers to assign class labels to web pages. We used the WebKB and Conference datasets in our experiments, and we showed that using the ACO for feature selection improves both accuracy and runtime performance of classification. We also showed that the proposed ACO based algorithm can select better features with respect to the well-known information gain and chi square feature selection methods. PMID:25136678

  2. An ant colony optimization based feature selection for web page classification.

    PubMed

    Saraç, Esra; Özel, Selma Ayşe

    2014-01-01

    The increased popularity of the web has caused the inclusion of huge amount of information to the web, and as a result of this explosive information growth, automated web page classification systems are needed to improve search engines' performance. Web pages have a large number of features such as HTML/XML tags, URLs, hyperlinks, and text contents that should be considered during an automated classification process. The aim of this study is to reduce the number of features to be used to improve runtime and accuracy of the classification of web pages. In this study, we used an ant colony optimization (ACO) algorithm to select the best features, and then we applied the well-known C4.5, naive Bayes, and k nearest neighbor classifiers to assign class labels to web pages. We used the WebKB and Conference datasets in our experiments, and we showed that using the ACO for feature selection improves both accuracy and runtime performance of classification. We also showed that the proposed ACO based algorithm can select better features with respect to the well-known information gain and chi square feature selection methods.

  3. Comments on Hudesman and Page's reply to Fudin's comments on Hudesman, Page and Rautianen's subliminal psychodynamic activation experiment.

    PubMed

    Fudin, R

    1993-06-01

    Hudesman and Page's contention that Gustafson and Källmén's 1991 results indicate that subsequent subliminal psychodynamic activation experiments do not require the controls suggested by Fudin in 1986 is questioned. The rationale for Fudin's 1993 comment concerning the limited generalizability of Hudesman, et al.'s (1992) results, a comment Hudesman and Page contended is unfounded, is discussed. PMID:8321599

  4. 76 FR 2754 - Agency Information Collection (Pay Now Enter Info Page) Activity Under OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-14

    ... AFFAIRS Agency Information Collection (Pay Now Enter Info Page) Activity Under OMB Review AGENCY: Office... Info Page. OMB Control Number: 2900-0663. Type of Review: Extension of a currently approved collection... payments through VA's Pay Now Enter Info Page website. Data enter on the Pay Now Enter Info Page...

  5. Shakespeare Page to Stage: An Active Approach to "Othello."

    ERIC Educational Resources Information Center

    Thomas, Peter

    1994-01-01

    Presents an account of how one English teacher taught William Shakespeare's "Othello" through dramatics in a challenging way. Considers how teachers of drama might discuss props, stage directions, and the proper handling of Desdemona's handkerchief. Explains how teachers should try to take the plays from "page to stage." (HB)

  6. 75 FR 76080 - Agency Information Collection (VetBiz Vendor Information Pages Verification Program) Activity...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-07

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF VETERANS AFFAIRS Agency Information Collection (VetBiz Vendor Information Pages Verification Program) Activity... . Please refer to ``OMB Control No. 2900- 0675.'' SUPPLEMENTAL INFORMATION: Title: VetBiz...

  7. The Green Pages: Environmental Education Activities K-12.

    ERIC Educational Resources Information Center

    Clearing, 1990

    1990-01-01

    Presented are 20 science activities for students K-12. Topics include role playing, similarities between urban and forest communities, ecosystems, garbage, recycling, food production, habitats, insects, tidal zone, animals, diversity, interest groups, rivers, spaceship earth, ecological interactions, and the cost of recreation. (KR)

  8. The Green Pages: Environmental Education Activities K-12.

    ERIC Educational Resources Information Center

    Clearing, 1991

    1991-01-01

    Presented are 38 environmental education activities for grades K-12. Topics include seed dispersal, food chains, plant identification, sizes and shapes, trees, common names, air pollution, recycling, temperature, litter, water conservation, photography, insects, urban areas, diversity, natural cycles, rain, erosion, phosphates, human population,…

  9. The Green Pages: Environmental Education Activities K-12.

    ERIC Educational Resources Information Center

    Clearing, 1990

    1990-01-01

    Presented are 37 environmental science activities for students in grades K-12. Topics include water pollution, glaciers, protective coloration, shapes in nature, environmental impacts, recycling, creative writing, litter, shapes found in nature, color, rain cycle, waste management, plastics, energy, pH, landfills, runoff, watersheds,…

  10. Final comments on Hudesman, Page, and Rautiainen's (1992) subliminal psychodynamic activation experiment.

    PubMed

    Fudin, R

    1993-10-01

    Hudesman, et al.'s (1992) contention that their finding shows that subliminal psychodynamic activation (SPA) improved academic performance is questioned. That experiment lacked controls outlined by Fudin in 1986 which are needed to support the assumption that a positive SPA outcome is effected because the meaning of an entire experimental message is encoded. In 1993 Hudesman and Page argued that Gustafson and Källmén's 1991 results, obtained with such controls, indicated that the controls do not have to be used in subsequent SPA experiments. The 1990 results of Greenberg and of Kothera, Fudin, and Nicastro, however, do not support those of Gustafson and Källmén. From a different perspective, it is argued that good experimental controls are needed in all SPA experiments because they increase internal validity. Given that Hudesman, et al.'s subjects scored in a limited range on the mathematics portion of the 1978 CUNY Skills Assessment Test, the implication that their result can be generalized to all subjects is questioned. PMID:8247655

  11. Coevolution of active vision and feature selection.

    PubMed

    Floreano, Dario; Kato, Toshifumi; Marocco, Davide; Sauser, Eric

    2004-03-01

    We show that complex visual tasks, such as position- and size-invariant shape recognition and navigation in the environment, can be tackled with simple architectures generated by a coevolutionary process of active vision and feature selection. Behavioral machines equipped with primitive vision systems and direct pathways between visual and motor neurons are evolved while they freely interact with their environments. We describe the application of this methodology in three sets of experiments, namely, shape discrimination, car driving, and robot navigation. We show that these systems develop sensitivity to a number of oriented, retinotopic, visual-feature-oriented edges, corners, height, and a behavioral repertoire to locate, bring, and keep these features in sensitive regions of the vision system, resembling strategies observed in simple insects. PMID:15052484

  12. Coevolution of active vision and feature selection.

    PubMed

    Floreano, Dario; Kato, Toshifumi; Marocco, Davide; Sauser, Eric

    2004-03-01

    We show that complex visual tasks, such as position- and size-invariant shape recognition and navigation in the environment, can be tackled with simple architectures generated by a coevolutionary process of active vision and feature selection. Behavioral machines equipped with primitive vision systems and direct pathways between visual and motor neurons are evolved while they freely interact with their environments. We describe the application of this methodology in three sets of experiments, namely, shape discrimination, car driving, and robot navigation. We show that these systems develop sensitivity to a number of oriented, retinotopic, visual-feature-oriented edges, corners, height, and a behavioral repertoire to locate, bring, and keep these features in sensitive regions of the vision system, resembling strategies observed in simple insects.

  13. Desired features of smartphone applications promoting physical activity.

    PubMed

    Rabin, Carolyn; Bock, Beth

    2011-12-01

    Approximately one-third of adults in the United States are physically inactive. This is a significant public health concern as physical activity (PA) can influence the risk of cardiovascular disease, diabetes, and certain forms of cancer. To minimize these health risks, effective PA interventions must be developed and disseminated to the vast number of individuals who remain sedentary. Smartphone technology presents an exciting opportunity for delivering PA interventions remotely. Although a number of PA applications are currently available for smartphones, these "apps" are not based on established theories of health behavior change and most do not include evidence-based features (e.g., reinforcement and goal setting). Our aim was to collect formative data to develop a smartphone PA app that is empirically and theoretically-based and incorporates user preferences. We recruited 15 sedentary adults to test three currently available PA smartphone apps and provide qualitative and quantitative feedback. Findings indicate that users have a number of specific preferences with regard to PA app features, including that apps provide automatic tracking of PA (e.g., steps taken and calories burned), track progress toward PA goals, and integrate a music feature. Participants also preferred that PA apps be flexible enough to be used with several types of PA, and have well-documented features and user-friendly interfaces (e.g., a one-click main page). When queried by the researcher, most participants endorsed including goal-setting and problem-solving features. These findings provide a blue print for developing a smartphone PA app that incorporates evidence-based components and user preferences. PMID:22010977

  14. Desired features of smartphone applications promoting physical activity.

    PubMed

    Rabin, Carolyn; Bock, Beth

    2011-12-01

    Approximately one-third of adults in the United States are physically inactive. This is a significant public health concern as physical activity (PA) can influence the risk of cardiovascular disease, diabetes, and certain forms of cancer. To minimize these health risks, effective PA interventions must be developed and disseminated to the vast number of individuals who remain sedentary. Smartphone technology presents an exciting opportunity for delivering PA interventions remotely. Although a number of PA applications are currently available for smartphones, these "apps" are not based on established theories of health behavior change and most do not include evidence-based features (e.g., reinforcement and goal setting). Our aim was to collect formative data to develop a smartphone PA app that is empirically and theoretically-based and incorporates user preferences. We recruited 15 sedentary adults to test three currently available PA smartphone apps and provide qualitative and quantitative feedback. Findings indicate that users have a number of specific preferences with regard to PA app features, including that apps provide automatic tracking of PA (e.g., steps taken and calories burned), track progress toward PA goals, and integrate a music feature. Participants also preferred that PA apps be flexible enough to be used with several types of PA, and have well-documented features and user-friendly interfaces (e.g., a one-click main page). When queried by the researcher, most participants endorsed including goal-setting and problem-solving features. These findings provide a blue print for developing a smartphone PA app that incorporates evidence-based components and user preferences.

  15. Land Use and Climate Impacts on Fluvial Systems (LUCIFS): A PAGES - Focus 4 (PHAROS) research activity

    NASA Astrophysics Data System (ADS)

    Dearing, John; Hoffmann, Thomas

    2010-05-01

    LUCIFS is a global research program which is concerned with understanding past interactions between climate, human activity and fluvial systems. Its focus is on evaluating the geomorphic impact of humans on landscapes, with a strong emphasis on geomorphological and sedimentological perspectives on mid- to long-term man-landscape interactions. Of particular relevance are aspects of sediment redistribution systems such as non-linear behaviour, the role of system configuration, scale effects, and emergent properties Over the last decade the LUCIFS program has been investigating both contemporary and long-term river response to global change with the principal aims of i)quantifying land use and climate change impacts of river-borne fluxes of water, sediment, C, N and P; ii) identification of key controls on these fluxes at the catchment scale; and iii) identification of the feedback on both human society and biogeochemical cycles of long-term changes in the fluxes of these materials The major scientific tasks of the LUCIFS-program are: • synthesising results of regional case studies • identify regional gaps and encouraging new case studies • addressing research gaps and formulating new research questions • organising workshops and conferences In this paper we present the LUCIFS program within the new PAGES structure. LUCIFS is located in the Focus 4 (PHAROS) dealing with how a knowledge of human-climate-ecosystem interactions in the past can help inform understanding and management today. In conjunction with the other working groups HITE (Human Impacts on Terrestrial Ecosystems), LIMPACS (Human Impacts on Lake Ecosystems) and IHOPE (Integrated History of People on Earth) PHAROS aims to compare regional-scale reconstructions of environmental and climatic processes using natural archives, documentary and instrumental data, with evidence of past human activity obtained from historical, paleoecological and archaeological records.

  16. Basics. [A Compilation of Learning Activities Pages from Seven Issues of Instructor Magazine, September 1982 through March 1983 and May 1983.

    ERIC Educational Resources Information Center

    Instructor, 1983

    1983-01-01

    This collection of 18 learning activities pages focuses on the subject areas of science, language arts, mathematics, and social studies. The science activities pages concern the study of earthquakes, sound, environmental changes, snails and slugs, and friction. Many of the activities are in the form of experiments for the students to perform.…

  17. An Active Model for Facial Feature Tracking

    NASA Astrophysics Data System (ADS)

    Ahlberg, Jörgen

    2002-12-01

    We present a system for finding and tracking a face and extract global and local animation parameters from a video sequence. The system uses an initial colour processing step for finding a rough estimate of the position, size, and inplane rotation of the face, followed by a refinement step drived by an active model. The latter step refines the pre­vious estimate, and also extracts local animation parame­ters. The system is able to track the face and some facial features in near real-time, and can compress the result to a bitstream compliant to MPEG-4 face and body animation.

  18. The Green Pages Environmental Education Activities K-12: Gardens for Young Growing Lives.

    ERIC Educational Resources Information Center

    Larson, Jan

    1997-01-01

    Describes several gardening activities that can be kept simple or used as a foundation for more in-depth projects. Activities include setting up an indoor garden spot, making compost which helps students understand the terms "decompose" and "compost", watching plants drink in which students measure water movement in plants, making herb gardens,…

  19. Comments on Hudesman, Page, and Rautiainen's (1992) subliminal psychodynamic activation experiment.

    PubMed

    Fudin, R

    1993-02-01

    Hudesman, et al.'s (1992) contention that their finding and those of Ariam (1979), Parker (1982), and Cook (1985) show that subliminal psychodynamic activation (SPA) can improve academic performance is questioned. Results obtained from experiments using methodological innovations (Fudin, 1986) would allow a clearer interpretation of positive SPA outcomes. PMID:8451149

  20. The Foreign Language Feature Film and Language Teaching Activities.

    ERIC Educational Resources Information Center

    Chappell, Martin

    1986-01-01

    Analysis of foreign language films, featuring consideration of film sequence, image and film analysis, and literary adaptation, is an effective teaching activity with foreign language students. An example illustrates film analysis activities in a first-year French class. (CB)

  1. 47 CFR 79.109 - Activating accessibility features.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... ACCESSIBILITY OF VIDEO PROGRAMMING Apparatus § 79.109 Activating accessibility features. (a) Requirements... video programming transmitted in digital format simultaneously with sound, including apparatus designed to receive or display video programming transmitted in digital format using Internet protocol,...

  2. Extract the Relational Information of Static Features and Motion Features for Human Activities Recognition in Videos

    PubMed Central

    2016-01-01

    Both static features and motion features have shown promising performance in human activities recognition task. However, the information included in these features is insufficient for complex human activities. In this paper, we propose extracting relational information of static features and motion features for human activities recognition. The videos are represented by a classical Bag-of-Word (BoW) model which is useful in many works. To get a compact and discriminative codebook with small dimension, we employ the divisive algorithm based on KL-divergence to reconstruct the codebook. After that, to further capture strong relational information, we construct a bipartite graph to model the relationship between words of different feature set. Then we use a k-way partition to create a new codebook in which similar words are getting together. With this new codebook, videos can be represented by a new BoW vector with strong relational information. Moreover, we propose a method to compute new clusters from the divisive algorithm's projective function. We test our work on the several datasets and obtain very promising results. PMID:27656199

  3. Extract the Relational Information of Static Features and Motion Features for Human Activities Recognition in Videos

    PubMed Central

    2016-01-01

    Both static features and motion features have shown promising performance in human activities recognition task. However, the information included in these features is insufficient for complex human activities. In this paper, we propose extracting relational information of static features and motion features for human activities recognition. The videos are represented by a classical Bag-of-Word (BoW) model which is useful in many works. To get a compact and discriminative codebook with small dimension, we employ the divisive algorithm based on KL-divergence to reconstruct the codebook. After that, to further capture strong relational information, we construct a bipartite graph to model the relationship between words of different feature set. Then we use a k-way partition to create a new codebook in which similar words are getting together. With this new codebook, videos can be represented by a new BoW vector with strong relational information. Moreover, we propose a method to compute new clusters from the divisive algorithm's projective function. We test our work on the several datasets and obtain very promising results.

  4. Promoting metacognition in first year anatomy laboratories using plasticine modeling and drawing activities: a pilot study of the "blank page" technique.

    PubMed

    Naug, Helen L; Colson, Natalie J; Donner, Daniel G

    2011-01-01

    Many first year students of anatomy and physiology courses demonstrate an inability to self-regulate their learning. To help students increase their awareness of their own learning in a first year undergraduate anatomy course, we piloted an exercise that incorporated the processes of (1) active learning: drawing and plasticine modeling and (2) metacognition: planning, monitoring, reaction, and reflection. The activity was termed "blank page" because all learning cues were removed and students had to create models and diagrams from reflection and recall. Two hundred and eighty-two students responded to a questionnaire reporting qualitative feedback on the exercise. Based on student responses, the "blank page" activity was a positive learning experience and confirmed a need to teach metacognitive skills. From this pilot study, we established that drawing or plasticine modeling is an excellent vehicle for demonstration of the metacognitive processes that enable self-regulation: a known predictor of academic success. PMID:21618445

  5. Promoting metacognition in first year anatomy laboratories using plasticine modeling and drawing activities: a pilot study of the "blank page" technique.

    PubMed

    Naug, Helen L; Colson, Natalie J; Donner, Daniel G

    2011-01-01

    Many first year students of anatomy and physiology courses demonstrate an inability to self-regulate their learning. To help students increase their awareness of their own learning in a first year undergraduate anatomy course, we piloted an exercise that incorporated the processes of (1) active learning: drawing and plasticine modeling and (2) metacognition: planning, monitoring, reaction, and reflection. The activity was termed "blank page" because all learning cues were removed and students had to create models and diagrams from reflection and recall. Two hundred and eighty-two students responded to a questionnaire reporting qualitative feedback on the exercise. Based on student responses, the "blank page" activity was a positive learning experience and confirmed a need to teach metacognitive skills. From this pilot study, we established that drawing or plasticine modeling is an excellent vehicle for demonstration of the metacognitive processes that enable self-regulation: a known predictor of academic success.

  6. Learning Behavior Characterization with Multi-Feature, Hierarchical Activity Sequences

    ERIC Educational Resources Information Center

    Ye, Cheng; Segedy, James R.; Kinnebrew, John S.; Biswas, Gautam

    2015-01-01

    This paper discusses Multi-Feature Hierarchical Sequential Pattern Mining, MFH-SPAM, a novel algorithm that efficiently extracts patterns from students' learning activity sequences. This algorithm extends an existing sequential pattern mining algorithm by dynamically selecting the level of specificity for hierarchically-defined features…

  7. Masked Primes Activate Feature Representations in Reading Aloud

    ERIC Educational Resources Information Center

    Mousikou, Petroula; Roon, Kevin D.; Rastle, Kathleen

    2015-01-01

    Theories of reading aloud are silent about the role of subphonemic/subsegmental representations in translating print to sound. However, there is empirical evidence suggesting that feature representations are activated in speech production and visual word recognition. In the present study, we sought to determine whether masked primes activate…

  8. Unconscious Semantic Activation Depends on Feature-Specific Attention Allocation

    ERIC Educational Resources Information Center

    Spruyt, Adriaan; De Houwer, Jan; Everaert, Tom; Hermans, Dirk

    2012-01-01

    We examined whether semantic activation by subliminally presented stimuli is dependent upon the extent to which participants assign attention to specific semantic stimulus features and stimulus dimensions. Participants pronounced visible target words that were preceded by briefly presented, masked prime words. Both affective and non-affective…

  9. Masked primes activate feature representations in reading aloud.

    PubMed

    Mousikou, Petroula; Roon, Kevin D; Rastle, Kathleen

    2015-05-01

    Theories of reading aloud are silent about the role of subphonemic/subsegmental representations in translating print to sound. However, there is empirical evidence suggesting that feature representations are activated in speech production and visual word recognition. In the present study, we sought to determine whether masked primes activate feature representations in reading aloud using a variation of the masked onset priming effect (MOPE). We found that target nonwords (e.g., BAF) were read aloud faster when preceded by masked nonword primes that shared their initial phoneme with the target (e.g., bez), or primes whose initial phoneme shared all features except voicing with the first phoneme of the target (e.g., piz), compared with unrelated primes (e.g., suz). We obtained the same result in 2 experiments that used different participants and prime durations (around 60 ms in Experiment 1 and 50 ms in Experiment 2). The significant masked feature priming effect that was observed in both experiments converges with the empirical evidence in the speech production and visual word recognition domains indicating a functional role for features in reading aloud. Our findings motivate the further development of current theories of reading aloud and have important implications for extant theories of speech production. PMID:25528097

  10. Web Page Authoring Tools: Comparison and Trends.

    ERIC Educational Resources Information Center

    Craney, Linda

    Initially available from universities and individual enthusiasts, software tools to author World Wide Web pages are maturing into very feature-rich applications and are now offered by large corporations. These applications are enabling more companies to create and maintain pages themselves on the Web or on corporate Intranets. The market continues…

  11. ON THE 10 mum SILICATE FEATURE IN ACTIVE GALACTIC NUCLEI

    SciTech Connect

    Nikutta, Robert; Elitzur, Moshe; Lacy, Mark E-mail: moshe@pa.uky.ed

    2009-12-20

    The 10 mum silicate feature observed with Spitzer in active galactic nuclei (AGNs) reveals some puzzling behavior. It (1) has been detected in emission in type 2 sources, (2) shows broad, flat-topped emission peaks shifted toward long wavelengths in several type 1 sources, and (3) is not seen in deep absorption in any source observed so far. We solve all three puzzles with our clumpy dust radiative transfer formalism. Addressing (1), we present the spectral energy distribution (SED) of SST1721+6012, the first type 2 quasar observed to show a clear 10 mum silicate feature in emission. Such emission arises in models of the AGN torus easily when its clumpy nature is taken into account. We constructed a large database of clumpy torus models and performed extensive fitting of the observed SED. We find that the cloud radial distribution varies as r {sup -1.5} and the torus contains 2-4 clouds along radial equatorial rays, each with optical depth at visual approx60-80. The source bolometric luminosity is approx3 x 10{sup 12} L{sub sun}. Our modeling suggests that approx<35% of objects with tori sharing these characteristics and geometry would have their central engines obscured. This relatively low obscuration probability can explain the clear appearance of the 10 mum emission feature in SST1721+6012 together with its rarity among other QSO2. Investigating (2), we also fitted the SED of PG1211+143, one of the first type 1 QSOs with a 10 mum silicate feature detected in emission. Together with other similar sources, this QSO appears to display an unusually broadened feature whose peak is shifted toward longer wavelengths. Although this led to suggestions of non-standard dust chemistry in these sources, our analysis fits such SEDs with standard galactic dust; the apparent peak shifts arise from simple radiative transfer effects. Regarding (3), we find additionally that the distribution of silicate feature strengths among clumpy torus models closely resembles the observed

  12. Features of the Active Evening Plasma Sheet from MMS

    NASA Astrophysics Data System (ADS)

    Moore, T. E.; Chandler, M. O.; Avanov, L. A.; Burch, J. L.; Coffey, V. N.; Ergun, R. E.; Fuselier, S. A.; Gershman, D. J.; Giles, B. L.; Lavraud, B.; MacDonald, E.; Mauk, B.; Mukai, T.; Nakamura, R.; Pollock, C. J.; Russell, C. T.; Saito, Y.; Sauvaud, J. A.; Torbert, R. B.; Yokota, S.

    2015-12-01

    The Magnetospheric Multiscale (MMS) mission, consisting of four identical plasmas and fields observatories, was launched into a 12 RE elliptical equatorial orbit in March 2015 and was in the process of being commissioned through August 2015. During commissioning, the orbit apogee rotated from near midnight through the evening toward the dusk sector and occasionally captured new observations of the plasma sheet, its boundary layers, and the magnetospheric tail lobes. On 22-23 June, an especially active plasma sheet was involved in a major geospace storm that developed a ring current with 200 nT DST. We report on the ion kinetic and flow features of this active plasma sheet, comparing them with familiar observations from earlier missions, as an exercise in validating the MMS observations and assessing their capabilities to provide higher time resolution in multi-point views of thin, fast-moving structures. The observed features include but are not limited to cold lobal wind streams in the lobes, tailward flowing auroral beams and conics, hot earthward field-aligned flows and counter-flows, fast cross-field convection of some flows toward the neutral sheet, and the hot isotropic plasma sheet proper. Relationships between these features, the ionosphere, and the reconnecting magnetotail will be explored and discussed, seeking preliminary conclusions.

  13. Wetlands and Web Pages.

    ERIC Educational Resources Information Center

    Tisone-Bartels, Dede

    1998-01-01

    Argues that the preservation of areas like the Shoreline Park (California) wetlands depends on educating students about the value of natural resources. Describes the creation of a Web page on the wetlands for third-grade students by seventh-grade art and ecology students. Outlines the technical process of developing a Web page. (DSK)

  14. Making Pages That Move.

    ERIC Educational Resources Information Center

    Gepner, Ivan

    2001-01-01

    Explains the mechanism of producing dynamic computer pages which is based on three technologies: (1) the document object model; (2) cascading stylesheets; and (3) javascript. Discusses the applications of these techniques in genetics and developmental biology. (YDS)

  15. Modeling place field activity with hierarchical slow feature analysis

    PubMed Central

    Schönfeld, Fabian; Wiskott, Laurenz

    2015-01-01

    What are the computational laws of hippocampal activity? In this paper we argue for the slowness principle as a fundamental processing paradigm behind hippocampal place cell firing. We present six different studies from the experimental literature, performed with real-life rats, that we replicated in computer simulations. Each of the chosen studies allows rodents to develop stable place fields and then examines a distinct property of the established spatial encoding: adaptation to cue relocation and removal; directional dependent firing in the linear track and open field; and morphing and scaling the environment itself. Simulations are based on a hierarchical Slow Feature Analysis (SFA) network topped by a principal component analysis (ICA) output layer. The slowness principle is shown to account for the main findings of the presented experimental studies. The SFA network generates its responses using raw visual input only, which adds to its biological plausibility but requires experiments performed in light conditions. Future iterations of the model will thus have to incorporate additional information, such as path integration and grid cell activity, in order to be able to also replicate studies that take place during darkness. PMID:26052279

  16. Page turning system

    NASA Technical Reports Server (NTRS)

    Kerley, James J. (Inventor); Eklund, Wayne D. (Inventor)

    1992-01-01

    A device for holding reading materials for use by readers without arm mobility is presented. The device is adapted to hold the reading materials in position for reading with the pages displayed to enable turning by use of a rubber tipped stick that is held in the mouth and has a pair of rectangular frames. The frames are for holding and positioning the reading materials opened in reading posture with the pages displayed at a substantially unobstructed sighting position for reading. The pair of rectangular frames are connected to one another by a hinge so the angle between the frames may be varied thereby varying the inclination of the reading material. A pair of bent spring mounted wires for holding opposing pages of the reading material open for reading without substantial visual interference of the pages is mounted to the base. The wires are also adjustable to the thickness of the reading material and have a variable friction adjustment. This enables the force of the wires against the pages to be varied and permits the reader to manipulate the pages with the stick.

  17. Handley Page metal construction

    NASA Technical Reports Server (NTRS)

    1929-01-01

    In this report Handley Page construction techniques are shown such as: solid-drawn tubular duralumin spars are used in the stabilizer; plain channel sections are used extensively for minor components; and the manner of assembling them into a stabilizer compression strut is shown.

  18. Physical activity advertisements that feature daily well-being improve autonomy and body image in overweight women but not men.

    PubMed

    Segar, Michelle L; Updegraff, John A; Zikmund-Fisher, Brian J; Richardson, Caroline R

    2012-01-01

    The reasons for exercising that are featured in health communications brand exercise and socialize individuals about why they should be physically active. Discovering which reasons for exercising are associated with high-quality motivation and behavioral regulation is essential to promoting physical activity and weight control that can be sustained over time. This study investigates whether framing physical activity in advertisements featuring distinct types of goals differentially influences body image and behavioral regulations based on self-determination theory among overweight and obese individuals. Using a three-arm randomized trial, overweight and obese women and men (aged 40-60 yr, n = 1690) read one of three ads framing physical activity as a way to achieve (1) better health, (2) weight loss, or (3) daily well-being. Framing effects were estimated in an ANOVA model with pairwise comparisons using the Bonferroni correction. This study showed that there are immediate framing effects on physical activity behavioral regulations and body image from reading a one-page advertisement about physical activity and that gender and BMI moderate these effects. Framing physical activity as a way to enhance daily well-being positively influenced participants' perceptions about the experience of being physically active and enhanced body image among overweight women, but not men. The experiment had less impact among the obese study participants compared to those who were overweight. These findings support a growing body of research suggesting that, compared to weight loss, framing physical activity for daily well-being is a better gain-frame message for overweight women in midlife.

  19. Physical Activity Advertisements That Feature Daily Well-Being Improve Autonomy and Body Image in Overweight Women but Not Men

    PubMed Central

    Segar, Michelle L.; Updegraff, John A.; Zikmund-Fisher, Brian J.; Richardson, Caroline R.

    2012-01-01

    The reasons for exercising that are featured in health communications brand exercise and socialize individuals about why they should be physically active. Discovering which reasons for exercising are associated with high-quality motivation and behavioral regulation is essential to promoting physical activity and weight control that can be sustained over time. This study investigates whether framing physical activity in advertisements featuring distinct types of goals differentially influences body image and behavioral regulations based on self-determination theory among overweight and obese individuals. Using a three-arm randomized trial, overweight and obese women and men (aged 40–60 yr, n = 1690) read one of three ads framing physical activity as a way to achieve (1) better health, (2) weight loss, or (3) daily well-being. Framing effects were estimated in an ANOVA model with pairwise comparisons using the Bonferroni correction. This study showed that there are immediate framing effects on physical activity behavioral regulations and body image from reading a one-page advertisement about physical activity and that gender and BMI moderate these effects. Framing physical activity as a way to enhance daily well-being positively influenced participants' perceptions about the experience of being physically active and enhanced body image among overweight women, but not men. The experiment had less impact among the obese study participants compared to those who were overweight. These findings support a growing body of research suggesting that, compared to weight loss, framing physical activity for daily well-being is a better gain-frame message for overweight women in midlife. PMID:22701782

  20. Native SDS-PAGE: high resolution electrophoretic separation of proteins with retention of native properties including bound metal ions.

    PubMed

    Nowakowski, Andrew B; Wobig, William J; Petering, David H

    2014-05-01

    Sodium dodecyl-sulfate polyacrylamide gel electrophoresis (SDS-PAGE) is commonly used to obtain high resolution separation of complex mixtures of proteins. The method initially denatures the proteins that will undergo electrophoresis. Although covalent structural features of resolved proteins can be determined with SDS-PAGE, functional properties are destroyed, including the presence of non-covalently bound metal ions. To address this shortcoming, blue-native (BN)-PAGE has been introduced. This method retains functional properties but at the cost of protein resolving power. To address the need for a high resolution PAGE method that results in the separation of native proteins, experiments tested the impact of changing the conditions of SDS-PAGE on the quality of protein separation and retention of functional properties. Removal of SDS and EDTA from the sample buffer together with omission of a heating step had no effect on the results of PAGE. Reduction of SDS in the running buffer from 0.1% to 0.0375% together with deletion of EDTA also made little impact on the quality of the electrophoretograms of fractions of pig kidney (LLC-PK1) cell proteome in comparison with that achieved with the SDS-PAGE method. The modified conditions were called native (N)SDS-PAGE. Retention of Zn(2+) bound in proteomic samples increased from 26 to 98% upon shifting from standard to modified conditions. Moreover, seven of nine model enzymes, including four Zn(2+) proteins that were subjected to NSDS-PAGE retained activity. All nine were active in BN-PAGE, whereas all underwent denaturation during SDS-PAGE. Metal retention after electrophoresis was additionally confirmed using laser ablation-inductively coupled plasma-mass spectrometry and in-gel Zn-protein staining using the fluorophore TSQ.

  1. Native SDS-PAGE: High Resolution Electrophoretic Separation of Proteins With Retention of Native Properties Including Bound Metal Ions

    PubMed Central

    Nowakowski, Andrew B.; Wobig, William J.; Petering, David H.

    2014-01-01

    Sodium dodecyl-sulfate polyacrylamide gel electrophoresis (SDS-PAGE) is commonly used to obtain high resolution separation of complex mixtures of proteins. The method initially denatures the proteins that will undergo electrophoresis. Although covalent structural features of resolved proteins can be determined with SDS-PAGE, functional properties are destroyed, including the presence of non-covalently bound metal ions. To address this shortcoming, blue-native (BN)-PAGE has been introduced. This method retains functional properties but at the cost of protein resolving power. To address the need for a high resolution PAGE method that results in the separation of native proteins, experiments tested the impact of changing the conditions of SDS-PAGE on the quality of protein separation and retention of functional properties. Removal of SDS and EDTA from the sample buffer together with omission of a heating step had no effect on the results of PAGE. Reduction of SDS in the running buffer from 0.1% to 0.0375% together with deletion of EDTA also made little impact on the quality of the electrophoretograms of fractions of pig kidney (LLC-PK1) cell proteome in comparison with that achieved with the SDS-PAGE method. The modified conditions were called native (N)SDS-PAGE. Retention of Zn2+ bound in proteomic samples increased from 26 to 98% upon shifting from standard to modified conditions. Moreover, seven of nine model enzymes, including four Zn2+ proteins that were subjected to NSDS-PAGE retained activity. All nine were active in BN-PAGE, whereas all underwent denaturation during SDS-PAGE. Metal retention after electrophoresis was additionally confirmed using laser ablation-inductively coupled plasma-mass spectrometry and in-gel Zn-protein staining using the fluorophore TSQ. PMID:24686569

  2. Feature Selection in Classification of Eye Movements Using Electrooculography for Activity Recognition

    PubMed Central

    Mala, S.; Latha, K.

    2014-01-01

    Activity recognition is needed in different requisition, for example, reconnaissance system, patient monitoring, and human-computer interfaces. Feature selection plays an important role in activity recognition, data mining, and machine learning. In selecting subset of features, an efficient evolutionary algorithm Differential Evolution (DE), a very efficient optimizer, is used for finding informative features from eye movements using electrooculography (EOG). Many researchers use EOG signals in human-computer interactions with various computational intelligence methods to analyze eye movements. The proposed system involves analysis of EOG signals using clearness based features, minimum redundancy maximum relevance features, and Differential Evolution based features. This work concentrates more on the feature selection algorithm based on DE in order to improve the classification for faultless activity recognition. PMID:25574185

  3. An Analysis of Academic Library Web Pages for Faculty

    ERIC Educational Resources Information Center

    Gardner, Susan J.; Juricek, John Eric; Xu, F. Grace

    2008-01-01

    Web sites are increasingly used by academic libraries to promote key services and collections to teaching faculty. This study analyzes the content, location, language, and technological features of fifty-four academic library Web pages designed especially for faculty to expose patterns in the development of these pages.

  4. Tectonic activity and structural features of active intracontinental normal faults in the Weihe Graben, central China

    NASA Astrophysics Data System (ADS)

    Rao, Gang; Lin, Aiming; Yan, Bing; Jia, Dong; Wu, Xiaojun

    2014-12-01

    This study examines the tectonic activity and structural features of active normal faults in the Weihe Graben, central China. The Weihe Graben is an area with a high level of historic seismicity, and it is one of the intracontinental systems that developed since Tertiary in the extensional environment around the Ordos Block. Analysis of high-resolution remote-sensing imagery data, field observations, and radiocarbon dating results reveal the following: i) active normal faults are mainly developed within a zone < 500 m wide along the southern border of the eastern part of the Weihe Graben; ii) the active faults that have been identified are characterized by stepwise fault scarps dipping into the graben at angles of 40°-71°; iii) there are numerous discontinuous individual fault traces, ranging in length from a few tens of meters to 450 m (generally < 200 m); iv) fault zone structures, topographic features, and fault striations on the main fault planes indicate almost pure normal-slip; and v) late Pleistocene-Holocene terrace risers, loess, and alluvial deposits have been vertically offset by up to ~ 80 m, with a non-uniform dip-slip rate (throw-rates) ranging from ~ 2.1 to 5.7 mm/yr, mostly 2-3 mm/yr. Our results reveal that active normal faults have been developing in the Weihe Graben under an ongoing extensional environment, probably associated with the pre-existing graben and spreading of the continental crust, and this is in contrast with the Ordos Block and neighboring orogenic regions. These results provide new insights into the nature of extensional tectonic deformation in intracontinental graben systems.

  5. Project EAGLE (Early Academic Gifted Learning Experience): A Program for Gifted and Talented Students (Grades K-3)--Kindergarten Activity Booklets: Xanthus; Zhack; and Activity Pages H-Z.

    ERIC Educational Resources Information Center

    Merkoski, Kay

    Three activity booklets are presented for implementing Project EAGLE, an enrichment program for gifted and talented kindergarten children. The first activity booklet contains a poem by J. D. Evans titled "In Search of the Xanthus," which describes the search for an imaginary beast that leaves an "X" on the spot where it used to be. The second…

  6. MRI features of pediatric cerebral paragonimiasis in the active stage.

    PubMed

    Zhang, Jin Song; Huan, Yi; Sun, Li Jun; Zhang, Guang Yun; Ge, Ya Li; Zhao, Hai Tao

    2006-04-01

    We retrospectively reviewed the MR images of the brains of six children (age = 5-13 years) who had cerebral paragonimiasis in the early active stage. Diagnosis was based on a positive antibody test enzyme-linked immunosorbent assay (ELISA) for paragonimiasis in serum. The most common finding (in five patients) was irregular hemorrhage of various degrees. Moreover, in three cases some multiple irregular lesions with surrounding edema appeared to be conglomerated and aggregated. The rare appearance (in one patient) was a "tunnel sign," which showed the migrating track of the adult worm. In one patient with abscess and minimal hemorrhage, diffusion-weighted imaging (DWI) showed a heterogeneous high signal of lesions. Other findings included slight (one patient) or marked (one patient) irregular contrast enhancement, and large edematous areas surrounding small centers of hemorrhage (two patients). MR findings of conglomerated lesions with hemorrhage or tunnel sign may help to establish the diagnosis of active-stage cerebral paragonimiasis.

  7. Recognition of pornographic web pages by classifying texts and images.

    PubMed

    Hu, Weiming; Wu, Ou; Chen, Zhouyao; Fu, Zhouyu; Maybank, Steve

    2007-06-01

    With the rapid development of the World Wide Web, people benefit more and more from the sharing of information. However, Web pages with obscene, harmful, or illegal content can be easily accessed. It is important to recognize such unsuitable, offensive, or pornographic Web pages. In this paper, a novel framework for recognizing pornographic Web pages is described. A C4.5 decision tree is used to divide Web pages, according to content representations, into continuous text pages, discrete text pages, and image pages. These three categories of Web pages are handled, respectively, by a continuous text classifier, a discrete text classifier, and an algorithm that fuses the results from the image classifier and the discrete text classifier. In the continuous text classifier, statistical and semantic features are used to recognize pornographic texts. In the discrete text classifier, the naive Bayes rule is used to calculate the probability that a discrete text is pornographic. In the image classifier, the object's contour-based features are extracted to recognize pornographic images. In the text and image fusion algorithm, the Bayes theory is used to combine the recognition results from images and texts. Experimental results demonstrate that the continuous text classifier outperforms the traditional keyword-statistics-based classifier, the contour-based image classifier outperforms the traditional skin-region-based image classifier, the results obtained by our fusion algorithm outperform those by either of the individual classifiers, and our framework can be adapted to different categories of Web pages. PMID:17431300

  8. 8. Photocopy of printed page (original Page 30 of the ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Photocopy of printed page (original Page 30 of the Souvenir Program 1867-1967 Ridgely Centennial) Photographer unknown. Circa 1967. VIEW NORTHEAST, SOUTHWEST FRONT Ridgely's centennial was celebrated in 1967 and included in the souvenir brochure was page 30. This view shows the subject building with the 1950 modifications to provide for automotive traffic. It was a print of a current photograph. - 510 Central Avenue (Commercial Building), Ridgely, Caroline County, MD

  9. Identification of resting and active state EEG features of Alzheimer's disease using discrete wavelet transform.

    PubMed

    Ghorbanian, Parham; Devilbiss, David M; Verma, Ajay; Bernstein, Allan; Hess, Terry; Simon, Adam J; Ashrafiuon, Hashem

    2013-06-01

    Alzheimer's disease (AD) is associated with deficits in a number of cognitive processes and executive functions. Moreover, abnormalities in the electroencephalogram (EEG) power spectrum develop with the progression of AD. These features have been traditionally characterized with montage recordings and conventional spectral analysis during resting eyes-closed and resting eyes-open (EO) conditions. In this study, we introduce a single lead dry electrode EEG device which was employed on AD and control subjects during resting and activated battery of cognitive and sensory tasks such as Paced Auditory Serial Addition Test (PASAT) and auditory stimulations. EEG signals were recorded over the left prefrontal cortex (Fp1) from each subject. EEG signals were decomposed into sub-bands approximately corresponding to the major brain frequency bands using several different discrete wavelet transforms and developed statistical features for each band. Decision tree algorithms along with univariate and multivariate statistical analysis were used to identify the most predictive features across resting and active states, separately and collectively. During resting state recordings, we found that the AD patients exhibited elevated D4 (~4-8 Hz) mean power in EO state as their most distinctive feature. During the active states, however, the majority of AD patients exhibited larger minimum D3 (~8-12 Hz) values during auditory stimulation (18 Hz) combined with increased kurtosis of D5 (~2-4 Hz) during PASAT with 2 s interval. When analyzed using EEG recording data across all tasks, the most predictive AD patient features were a combination of the first two feature sets. However, the dominant discriminating feature for the majority of AD patients were still the same features as the active state analysis. The results from this small sample size pilot study indicate that although EEG recordings during resting conditions are able to differentiate AD from control subjects, EEG activity

  10. Function Follows Form: Activation of Shape and Function Features during Object Identification

    ERIC Educational Resources Information Center

    Yee, Eiling; Huffstetler, Stacy; Thompson-Schill, Sharon L.

    2011-01-01

    Most theories of semantic memory characterize knowledge of a given object as comprising a set of semantic features. But how does conceptual activation of these features proceed during object identification? We present the results of a pair of experiments that demonstrate that object recognition is a dynamically unfolding process in which function…

  11. Identifying Key Features of Effective Active Learning: The Effects of Writing and Peer Discussion

    ERIC Educational Resources Information Center

    Linton, Debra L.; Pangle, Wiline M.; Wyatt, Kevin H.; Powell, Karli N.; Sherwood, Rachel E.

    2014-01-01

    We investigated some of the key features of effective active learning by comparing the outcomes of three different methods of implementing active-learning exercises in a majors introductory biology course. Students completed activities in one of three treatments: discussion, writing, and discussion + writing. Treatments were rotated weekly between…

  12. OBSERVED, GIS, AND SELF-REPORTED ENVIRONMENTAL FEATURES AND ADOLESCENT PHYSICAL ACTIVITY

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Purpose: Examine associations among observed, self-reported, and Geographical Information Systems (GIS) environmental features and physical activity among adolescent males. Design: Cross-sectional study. Setting: Boy Scout troops and neighborhoods in Houston, Texas. Subjects: Two hundred and ten ...

  13. Designing a Web Page.

    ERIC Educational Resources Information Center

    Ackermann, Ernest; Hartman, Karen

    2000-01-01

    Presents technical issues, design considerations and resource sites to consider when designing a Web site. Discusses fonts; colors; screen resolutions; statement of purpose; audience; content; layout; size and number of images; spacing and emphasis; browser-supported features; grammar and spelling; revision/improvement; and testing. (AEF)

  14. Perceptual metrics and visualization tools for evaluation of page uniformity

    NASA Astrophysics Data System (ADS)

    Nguyen, Minh Q.; Jessome, Renee; Astling, Steve; Maggard, Eric; Nelson, Terry; Shaw, Mark; Allebach, Jan P.

    2014-01-01

    Uniformity is one of the issues of most critical concern for laser electrophotographic (EP) printers. Typically, full coverage constant-tint test pages are printed to assess uniformity. Exemplary nonuniformity defects include mottle, grain, pinholes, and "finger prints". It is a real challenge to make an overall Print Quality (PQ) assessment due to the large coverage of a letter-size, constant-tint printed test page and the variety of possible nonuniformity defects. In this paper, we propose a novel method that uses a block-based technique to analyze the page both visually and metrically. We use a grid of 150 pixels × 150 pixels ( ¼ inch × ¼ inch at 600-dpi resolution) square blocks throughout the scanned page. For each block, we examine two aspects: behavior of its pixels within the block (metrics of graininess) and behavior of the blocks within the printed page (metrics of nonuniformity). Both ΔE (CIE 1976) and the L* lightness channel are employed. For an input scanned page, we create eight visual outputs, each displaying a different aspect of nonuniformity. To apply machine learning, we train scanned pages of different 100% solid colors separately with the support vector machine (SVM) algorithm. We use two metrics as features for the SVM: average dispersion of page lightness and standard deviation in dispersion of page lightness. Our results show that we can predict, with 83% to 90% accuracy, the assignment by a print quality expert of one of two grades of uniformity in the print.

  15. ACSM Fit Society Page

    MedlinePlus

    ... Exercise Current Sports Medicine Reports Exercise and Sport Sciences Reviews ACSM's Health & Fitness Journal Guidelines Books & Multimedia Sports Medicine Basics Fact Sheets Sports Medicine & Physical Activity Marketplace Health & Physical Activity Reference Database Fit ...

  16. Control-Plate Regression (CPR) Normalization for High-Throughput Screens with Many Active Features.

    PubMed

    Murie, C; Barette, C; Lafanechère, L; Nadon, R

    2014-06-01

    Systematic error is present in all high-throughput screens, lowering measurement accuracy. Because screening occurs at the early stages of research projects, measurement inaccuracy leads to following up inactive features and failing to follow up active features. Current normalization methods take advantage of the fact that most primary-screen features (e.g., compounds) within each plate are inactive, which permits robust estimates of row and column systematic-error effects. Screens that contain a majority of potentially active features pose a more difficult challenge because even the most robust normalization methods will remove at least some of the biological signal. Control plates that contain the same feature in all wells can provide a solution to this problem by providing well-by-well estimates of systematic error, which can then be removed from the treatment plates. We introduce the robust control-plate regression (CPR) method, which uses this approach. CPR's performance is compared to a high-performing primary-screen normalization method in four experiments. These data were also perturbed to simulate screens with large numbers of active features to further assess CPR's performance. CPR performs almost as well as the best performing normalization methods with primary screens and outperforms the Z-score and equivalent methods with screens containing a large proportion of active features.

  17. Reese Sorenson's Individual Professional Page

    NASA Technical Reports Server (NTRS)

    Sorenson, Reese; Nixon, David (Technical Monitor)

    1998-01-01

    The subject document is a World Wide Web (WWW) page entitled, "Reese Sorenson's Individual Professional Page." Its can be accessed at "http://george.arc.nasa.gov/sorenson/personal/index.html". The purpose of this page is to make the reader aware of me, who I am, and what I do. It lists my work assignments, my computer experience, my place in the NASA hierarchy, publications by me, awards received by me, my education, and how to contact me. Writing this page was a learning experience, pursuant to an element in my Job Description which calls for me to be able to use the latest computers. This web page contains very little technical information, none of which is classified or sensitive.

  18. Human activity recognition based on feature selection in smart home using back-propagation algorithm.

    PubMed

    Fang, Hongqing; He, Lei; Si, Hao; Liu, Peng; Xie, Xiaolei

    2014-09-01

    In this paper, Back-propagation(BP) algorithm has been used to train the feed forward neural network for human activity recognition in smart home environments, and inter-class distance method for feature selection of observed motion sensor events is discussed and tested. And then, the human activity recognition performances of neural network using BP algorithm have been evaluated and compared with other probabilistic algorithms: Naïve Bayes(NB) classifier and Hidden Markov Model(HMM). The results show that different feature datasets yield different activity recognition accuracy. The selection of unsuitable feature datasets increases the computational complexity and degrades the activity recognition accuracy. Furthermore, neural network using BP algorithm has relatively better human activity recognition performances than NB classifier and HMM.

  19. RELATIONSHIPS BETWEEN GIS ENVIRONMENTAL FEATURES AND ADOLESCENT MALE PHYSICAL ACTIVITY: GIS CODING DIFFERENCES

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Background: It is not clear if relationships between GIS obtained environmental features and physical activity differ according to the method used to code GIS data. Methods: Physical activity levels of 210 Boy Scouts were measured by accelerometer. Numbers of parks, trails, gymnasia, bus stops, groc...

  20. Active shape models with invariant optimal features: application to facial analysis.

    PubMed

    Sukno, Federico M; Ordás, Sebastián; Butakoff, Constantine; Cruz, Santiago; Frangi, Alejandro F

    2007-07-01

    This work is framed in the field of statistical face analysis. In particular, the problem of accurate segmentation of prominent features of the face in frontal view images is addressed. We propose a method that generalizes linear Active Shape Models (ASMs), which have already been used for this task. The technique is built upon the development of a nonlinear intensity model, incorporating a reduced set of differential invariant features as local image descriptors. These features are invariant to rigid transformations, and a subset of them is chosen by Sequential Feature Selection for each landmark and resolution level. The new approach overcomes the unimodality and Gaussianity assumptions of classical ASMs regarding the distribution of the intensity values across the training set. Our methodology has demonstrated a significant improvement in segmentation precision as compared to the linear ASM and Optimal Features ASM (a nonlinear extension of the pioneer algorithm) in the tests performed on AR, XM2VTS, and EQUINOX databases. PMID:17496371

  1. Feature activation during word recognition: action, visual, and associative-semantic priming effects

    PubMed Central

    Lam, Kevin J. Y.; Dijkstra, Ton; Rueschemeyer, Shirley-Ann

    2015-01-01

    Embodied theories of language postulate that language meaning is stored in modality-specific brain areas generally involved in perception and action in the real world. However, the temporal dynamics of the interaction between modality-specific information and lexical-semantic processing remain unclear. We investigated the relative timing at which two types of modality-specific information (action-based and visual-form information) contribute to lexical-semantic comprehension. To this end, we applied a behavioral priming paradigm in which prime and target words were related with respect to (1) action features, (2) visual features, or (3) semantically associative information. Using a Go/No-Go lexical decision task, priming effects were measured across four different inter-stimulus intervals (ISI = 100, 250, 400, and 1000 ms) to determine the relative time course of the different features. Notably, action priming effects were found in ISIs of 100, 250, and 1000 ms whereas a visual priming effect was seen only in the ISI of 1000 ms. Importantly, our data suggest that features follow different time courses of activation during word recognition. In this regard, feature activation is dynamic, measurable in specific time windows but not in others. Thus the current study (1) demonstrates how multiple ISIs can be used within an experiment to help chart the time course of feature activation and (2) provides new evidence for embodied theories of language. PMID:26074836

  2. Code AI Personal Web Pages

    NASA Technical Reports Server (NTRS)

    Garcia, Joseph A.; Smith, Charles A. (Technical Monitor)

    1998-01-01

    The document consists of a publicly available web site (george.arc.nasa.gov) for Joseph A. Garcia's personal web pages in the AI division. Only general information will be posted and no technical material. All the information is unclassified.

  3. The Faculty Web Page: Contrivance or Continuation?

    ERIC Educational Resources Information Center

    Lennex, Lesia

    2007-01-01

    In an age of Internet education, what does it mean for a tenure/tenure-track faculty to have a web page? How many professors have web pages? If they have a page, what does it look like? Do they really need a web page at all? Many universities have faculty web pages. What do those collective pages look like? In what way do they represent the…

  4. From Monty Python to Total Recall: A Feature Film Activity for the Cognitive Psychology Course.

    ERIC Educational Resources Information Center

    Conner, David B.

    1996-01-01

    Describes a college psychology course activity designed to help students define the parameters of cognitive psychology. Students selected a feature film and a journal article that represented some aspect of cognitive psychology. They then wrote a paper discussing the theoretical and empirical connections between the sources and the topic. (MJP)

  5. Low activity of plasminogen activator: a common feature of non- iatrogenic comorbidities of schizophrenia.

    PubMed

    Hoirisch-Clapauch, Silvia; Nardi, Antonio E

    2015-01-01

    Understanding the pathogenesis of non-iatrogenic comorbidities of schizophrenia may provide insights into the pathogenesis of schizophrenia itself. First-episode, drug-naïve schizophrenia patients are at high risk of thromboembolic events, diseases related to substance abuse, sexual dysfunction, reproductive disorders, inflammatory and autoimmune diseases, as well as complications of hyperinsulinemia or hyperhomocysteinemia. This review focuses on the role of reduced plasminogen activator activity in non-iatrogenic comorbidity of schizophrenia. By preventing thrombus dissolution, low tissue plasminogen activator activity increases the risk of thrombotic events. Components of the plasminogen activator system also play a key role in reproduction. Both illicit drugs and tobacco increase plasminogen activator levels in the central nervous system, which seems to relieve symptoms of the mental disorder. Chronic alcoholism, sexual dysfunction, inflammatory and autoimmune disorders, and complications of hyperinsulinemia or hyperhomocysteinemia are somehow related to low plasminogen activator activity. Plasminogen activator mediates several neurochemical processes that seem to prevent or reverse gray-matter atrophy seen in first-episode schizophrenia patients. Such processes include cleavage of brain-derived neurotrophic factor precursor to an anti-apoptotic neurotrophin and activation of N-methyl-D-aspartate receptor. Controlled, randomized studies are needed to determine if measures aimed at correcting plasminogen activator activity can improve the quality of life, reduce morbidity and mortality rates, and particularly improve the course of schizophrenia. PMID:25714971

  6. Using Activity-Related Behavioural Features towards More Effective Automatic Stress Detection

    PubMed Central

    Giakoumis, Dimitris; Drosou, Anastasios; Cipresso, Pietro; Tzovaras, Dimitrios; Hassapis, George; Gaggioli, Andrea; Riva, Giuseppe

    2012-01-01

    This paper introduces activity-related behavioural features that can be automatically extracted from a computer system, with the aim to increase the effectiveness of automatic stress detection. The proposed features are based on processing of appropriate video and accelerometer recordings taken from the monitored subjects. For the purposes of the present study, an experiment was conducted that utilized a stress-induction protocol based on the stroop colour word test. Video, accelerometer and biosignal (Electrocardiogram and Galvanic Skin Response) recordings were collected from nineteen participants. Then, an explorative study was conducted by following a methodology mainly based on spatiotemporal descriptors (Motion History Images) that are extracted from video sequences. A large set of activity-related behavioural features, potentially useful for automatic stress detection, were proposed and examined. Experimental evaluation showed that several of these behavioural features significantly correlate to self-reported stress. Moreover, it was found that the use of the proposed features can significantly enhance the performance of typical automatic stress detection systems, commonly based on biosignal processing. PMID:23028461

  7. FUNCTION FOLLOWS FORM: ACTIVATION OF SHAPE & FUNCTION FEATURES DURING OBJECT IDENTIFICATION

    PubMed Central

    Yee, Eiling; Huffstetler, Stacy; Thompson-Schill, Sharon L.

    2011-01-01

    Most theories of semantic memory characterize knowledge of a given object as comprising a set of semantic features. But how does conceptual activation of these features proceed during object identification? We present the results of a pair of experiments that demonstrate that object recognition is a dynamically unfolding process in which function follows form. We used eye movements to explore whether activating one object’s concept leads to the activation of others that share perceptual (shape) or abstract (function) features. Participants viewed four-picture displays and clicked on the picture corresponding to a heard word. In critical trials, the conceptual representation of one of the objects in the display was similar in shape or function (i.e., its purpose) to the heard word. Importantly, this similarity was not apparent in the visual depictions (e.g., for the target “frisbee,” the shape-related object was a triangular slice of pizza – a shape that a frisbee cannot take); preferential fixations on the related object were therefore attributable to overlap of the conceptual representations on the relevant features. We observed relatedness effects for both shape and function, but shape effects occurred earlier than function effects. We discuss the implications of these findings for current accounts of the representation of semantic memory. PMID:21417543

  8. Multifractal features of magnetospheric dynamics and their dependence on solar activity

    NASA Astrophysics Data System (ADS)

    Gopinath, Sumesh

    2016-09-01

    In the present study, novel wavelet leaders (WL) based multifractal analysis has been used to get a better knowledge of the self-organization phenomena inherent in complex magnetospheric dynamics during disturbance and quiescent periods, focusing mainly on the intermittent features of auroral electrojet (AE) index. The results derived from the analysis certainly exhibit the phase transition property of magnetosphere system with respect to variabilities in the driving conditions. By using the novel WL method, solar activity dependence/independence of intermittency of magnetospheric proxies such as AE, SYM-H and Dst indices have been compared. The results indicate that the multifractality of AE index does not follow the solar activity cycle while intermittent features of SYM-H and Dst indices show high degree of solar activity dependence. This shows that along with the external solar wind perturbations, certain complex phenomena of internal origin also significantly modulate the dynamics of geomagnetic fluctuations in the auroral region.

  9. Design of Educational Web Pages

    ERIC Educational Resources Information Center

    Galan, Jose Gomez; Blanco, Soledad Mateos

    2004-01-01

    The methodological characteristics of teaching in primary and secondary education make it necessary to revise the pedagogical and instructive lines with which to introduce the new Information and Communication Technologies into the school context. The construction of Web pages that can be used to improve student learning is, therefore, fundamental…

  10. Learning through Web Page Design.

    ERIC Educational Resources Information Center

    Peel, Deborah

    2001-01-01

    Describes and evaluates the use of Web page design in an undergraduate course in the United Kingdom on town planning. Highlights include incorporating information and communication technologies into higher education; and a theoretical framework for the use of educational technology. (LRW)

  11. Ultra-low-molecular-weight heparins: precise structural features impacting specific anticoagulant activities.

    PubMed

    Lima, Marcelo A; Viskov, Christian; Herman, Frederic; Gray, Angel L; de Farias, Eduardo H C; Cavalheiro, Renan P; Sassaki, Guilherme L; Hoppensteadt, Debra; Fareed, Jawed; Nader, Helena B

    2013-03-01

    Ultra-low-molecular-weight heparins (ULMWHs) with better efficacy and safety ratios are under development; however, there are few structural data available. The main structural features and molecular weight of ULMWHs were studied and compared to enoxaparin. Their monosaccharide composition and average molecular weights were determined and preparations studied by nuclear magnetic resonance spectroscopy, scanning ultraviolet spectroscopy, circular dichroism and gel permeation chromatography. In general, ULMWHs presented higher 3-O-sulphated glucosamine and unsaturated uronic acid residues, the latter being comparable with their higher degree of depolymerisation. The analysis showed that ULMWHs are structurally related to LMWHs; however, their monosaccharide/oligosaccharide compositions and average molecular weights differed considerably explaining their different anticoagulant activities. The results relate structural features to activity, assisting the development of new and improved therapeutic agents, based on depolymerised heparin, for the prophylaxis and treatment of thrombotic disorders.

  12. Chemical features of Ganoderma polysaccharides with antioxidant, antitumor and antimicrobial activities.

    PubMed

    Ferreira, Isabel C F R; Heleno, Sandrina A; Reis, Filipa S; Stojkovic, Dejan; Queiroz, Maria João R P; Vasconcelos, M Helena; Sokovic, Marina

    2015-06-01

    Ganoderma genus comprises one of the most commonly studied species worldwide, Ganoderma lucidum. However, other Ganoderma species have been also reported as important sources of bioactive compounds. Polysaccharides are important contributors to the medicinal properties reported for Ganoderma species, as demonstrated by the numerous publications, including reviews, on this matter. Yet, what are the chemical features of Ganoderma polysaccharides that have bioactivity? In the present manuscript, the chemical features of Ganoderma polysaccharides with reported antioxidant, antitumor and antimicrobial activities (the most studied worldwide) are analyzed in detail. The composition of sugars (homo- versus hetero-glucans and other polysaccharides), type of glycosidic linkages, branching patterns, and linkage to proteins are discussed. Methods for extraction, isolation and identification are evaluated and, finally, the bioactivity of polysaccharidic extracts and purified compounds are discussed. The integration of data allows deduction of structure-activity relationships and gives clues to the chemical aspects involved in Ganoderma bioactivity.

  13. Music-induced emotions can be predicted from a combination of brain activity and acoustic features.

    PubMed

    Daly, Ian; Williams, Duncan; Hallowell, James; Hwang, Faustina; Kirke, Alexis; Malik, Asad; Weaver, James; Miranda, Eduardo; Nasuto, Slawomir J

    2015-12-01

    It is widely acknowledged that music can communicate and induce a wide range of emotions in the listener. However, music is a highly-complex audio signal composed of a wide range of complex time- and frequency-varying components. Additionally, music-induced emotions are known to differ greatly between listeners. Therefore, it is not immediately clear what emotions will be induced in a given individual by a piece of music. We attempt to predict the music-induced emotional response in a listener by measuring the activity in the listeners electroencephalogram (EEG). We combine these measures with acoustic descriptors of the music, an approach that allows us to consider music as a complex set of time-varying acoustic features, independently of any specific music theory. Regression models are found which allow us to predict the music-induced emotions of our participants with a correlation between the actual and predicted responses of up to r=0.234,p<0.001. This regression fit suggests that over 20% of the variance of the participant's music induced emotions can be predicted by their neural activity and the properties of the music. Given the large amount of noise, non-stationarity, and non-linearity in both EEG and music, this is an encouraging result. Additionally, the combination of measures of brain activity and acoustic features describing the music played to our participants allows us to predict music-induced emotions with significantly higher accuracies than either feature type alone (p<0.01).

  14. Feature transformation of neural activity with sparse and low-rank decomposition

    NASA Astrophysics Data System (ADS)

    Ni, Kang-Yu; Benvenuto, James; Bhattacharyya, Rajan; Millin, Rachel

    2015-03-01

    We propose a novel application of the sparse and low-rank (SLR) decomposition method to decode cognitive states for concept activity measured using fMRI BOLD. Current decoding methods attempt to reduce the dimensionality of fMRI BOLD signals to increase classification rate, but do not address the separable issues of multiple noise sources and complexity in the underlying data. Our feature transformation method extends SLR to separate task activity from the resting state and extract concept specific cognitive state. We show a significant increase in single trial decoding of concepts from fMRI BOLD using SLR to extract task specific cognitive state.

  15. Promoting Metacognition in First Year Anatomy Laboratories Using Plasticine Modeling and Drawing Activities: A Pilot Study of the "Blank Page" Technique

    ERIC Educational Resources Information Center

    Naug, Helen L.; Colson, Natalie J.; Donner, Daniel G.

    2011-01-01

    Many first year students of anatomy and physiology courses demonstrate an inability to self-regulate their learning. To help students increase their awareness of their own learning in a first year undergraduate anatomy course, we piloted an exercise that incorporated the processes of (1) active learning: drawing and plasticine modeling and (2)…

  16. Market study: Tactile paging system

    NASA Technical Reports Server (NTRS)

    1977-01-01

    A market survey was conducted regarding the commercialization potential and key market factors relevant to a tactile paging system for deaf-blind people. The purpose of the tactile paging system is to communicate to the deaf-blind people in an institutional environment. The system consists of a main console and individual satellite wrist units. The console emits three signals by telemetry to the wrist com (receiving unit) which will measure approximately 2 x 4 x 3/4 inches and will be fastened to the wrist by a strap. The three vibration signals are fire alarm, time period indication, and a third signal which will alert the wearer of the wrist com to the fact that the pin on the top of the wrist is emitting a morse coded message. The Morse code message can be felt and recognized with the finger.

  17. Photojournal Home Page Graphic 2007

    NASA Technical Reports Server (NTRS)

    2008-01-01

    This image is an unannotated version of the Photojournal Home Page graphic released in October 2007. This digital collage contains a highly stylized rendition of our solar system and points beyond. As this graphic was intended to be used as a navigation aid in searching for data within the Photojournal, certain artistic embellishments have been added (color, location, etc.). Several data sets from various planetary and astronomy missions were combined to create this image.

  18. Planetary Photojournal Home Page Graphic

    NASA Technical Reports Server (NTRS)

    2004-01-01

    This image is an unannotated version of the Planetary Photojournal Home Page graphic. This digital collage contains a highly stylized rendition of our solar system and points beyond. As this graphic was intended to be used as a navigation aid in searching for data within the Photojournal, certain artistic embellishments have been added (color, location, etc.). Several data sets from various planetary and astronomy missions were combined to create this image.

  19. Searchable solar feature catalogues

    NASA Astrophysics Data System (ADS)

    Zharkova, V. V.; Aboudarham, J.; Zharkov, S.; Ipson, S. S.; Benkhalil, A. K.; Fuller, N.

    The searchable Solar Feature Catalogues (SFCs) are developed from digitized solar images using automated pattern recognition techniques. The techniques were applied for the detection of sunspots, active regions, filaments and line-of-sight magnetic neutral lines in automatically standardized full disk solar images in Ca II K1, Ca II K3 and Ha lines taken at the Paris-Meudon Observatory and white light images and magnetograms from SOHO/MDI. The results of the automated recognition were verified with manual synoptic maps and available statistical data that revealed good detection accuracy. Based on the recognized parameters, a structured database of Solar Feature Catalogues was built on a MySQL server for every feature and published with various pre-designed search pages on the Bradford University web site http://www.cyber.brad.ac.uk/egso/SFC/. The SFCs with nine year coverage (1996-2004) is to be used for deeper investigation of the feature classification and solar activity forecast.

  20. Identifying Key Features of Effective Active Learning: The Effects of Writing and Peer Discussion

    PubMed Central

    Pangle, Wiline M.; Wyatt, Kevin H.; Powell, Karli N.; Sherwood, Rachel E.

    2014-01-01

    We investigated some of the key features of effective active learning by comparing the outcomes of three different methods of implementing active-learning exercises in a majors introductory biology course. Students completed activities in one of three treatments: discussion, writing, and discussion + writing. Treatments were rotated weekly between three sections taught by three different instructors in a full factorial design. The data set was analyzed by generalized linear mixed-effect models with three independent variables: student aptitude, treatment, and instructor, and three dependent (assessment) variables: change in score on pre- and postactivity clicker questions, and coding scores on in-class writing and exam essays. All independent variables had significant effects on student performance for at least one of the dependent variables. Students with higher aptitude scored higher on all assessments. Student scores were higher on exam essay questions when the activity was implemented with a writing component compared with peer discussion only. There was a significant effect of instructor, with instructors showing different degrees of effectiveness with active-learning techniques. We suggest that individual writing should be implemented as part of active learning whenever possible and that instructors may need training and practice to become effective with active learning. PMID:25185230

  1. Identifying key features of effective active learning: the effects of writing and peer discussion.

    PubMed

    Linton, Debra L; Pangle, Wiline M; Wyatt, Kevin H; Powell, Karli N; Sherwood, Rachel E

    2014-01-01

    We investigated some of the key features of effective active learning by comparing the outcomes of three different methods of implementing active-learning exercises in a majors introductory biology course. Students completed activities in one of three treatments: discussion, writing, and discussion + writing. Treatments were rotated weekly between three sections taught by three different instructors in a full factorial design. The data set was analyzed by generalized linear mixed-effect models with three independent variables: student aptitude, treatment, and instructor, and three dependent (assessment) variables: change in score on pre- and postactivity clicker questions, and coding scores on in-class writing and exam essays. All independent variables had significant effects on student performance for at least one of the dependent variables. Students with higher aptitude scored higher on all assessments. Student scores were higher on exam essay questions when the activity was implemented with a writing component compared with peer discussion only. There was a significant effect of instructor, with instructors showing different degrees of effectiveness with active-learning techniques. We suggest that individual writing should be implemented as part of active learning whenever possible and that instructors may need training and practice to become effective with active learning.

  2. Comparison of the surface features of two wood-based activated carbons

    SciTech Connect

    Salame, I.I.; Bandosz, T.J.

    2000-02-01

    The surface features of two carbons of wood origin were compared. One sample was manufactured using phosphoric acid activation and the other using potassium hydroxide activation. To check the susceptibility to oxidation and the stability of the porous structure, the samples were oxidized with ammonium persulfate. Structural properties of carbons and their oxidized counterparts were determined using sorption of nitrogen. Surface acidity was evaluated using Boehm titration, potentiometric titration, inverse gas chromatography, and diffuse reflectance FTIR. It was demonstrated that, despite the same wood origin, the carbons significantly differ in their pore structure and surface chemistry. The carbon obtained using KOH activation is homogeneously microporous with high surface area around 2,300 m{sup 2}/g (BET). On the other hand, the carbon manufactured using phosphoric acid contains a high volume of mesopores and its surface area is significantly lower. The carbons also differ in their surface chemistry and susceptibility to oxidation.

  3. Distinctive microstructural features of aged sodium silicate-activated slag concretes

    SciTech Connect

    San Nicolas, Rackel; Bernal, Susan A.; Mejía de Gutiérrez, Ruby; Deventer, Jannie S.J. van; Provis, John L.

    2014-11-15

    Electron microscopic characterisation of 7-year old alkali-activated blast-furnace slag concretes enabled the identification of distinct microstructural features, providing insight into the mechanisms by which these materials evolve over time. Backscattered electron images show the formation of Liesegang-type ring formations, suggesting that the reaction at advanced age is likely to follow an Oswald supersaturation–nucleation–depletion cycle. Segregation of Ca-rich veins, related to the formation of Ca(OH){sub 2}, is observed in microcracked regions due to the ongoing reaction between the pore solution and available calcium from remnant slag grains. A highly dense and uniform interfacial transition zone is identified between siliceous aggregate particles and the alkali activated slag binders, across the concretes assessed. Alkali-activated slag concretes retain a highly dense and stable microstructure at advanced ages, where any microcracks induced at early ages seem to be partially closing, and the remnant slag grains continue reacting.

  4. Music-induced emotions can be predicted from a combination of brain activity and acoustic features.

    PubMed

    Daly, Ian; Williams, Duncan; Hallowell, James; Hwang, Faustina; Kirke, Alexis; Malik, Asad; Weaver, James; Miranda, Eduardo; Nasuto, Slawomir J

    2015-12-01

    It is widely acknowledged that music can communicate and induce a wide range of emotions in the listener. However, music is a highly-complex audio signal composed of a wide range of complex time- and frequency-varying components. Additionally, music-induced emotions are known to differ greatly between listeners. Therefore, it is not immediately clear what emotions will be induced in a given individual by a piece of music. We attempt to predict the music-induced emotional response in a listener by measuring the activity in the listeners electroencephalogram (EEG). We combine these measures with acoustic descriptors of the music, an approach that allows us to consider music as a complex set of time-varying acoustic features, independently of any specific music theory. Regression models are found which allow us to predict the music-induced emotions of our participants with a correlation between the actual and predicted responses of up to r=0.234,p<0.001. This regression fit suggests that over 20% of the variance of the participant's music induced emotions can be predicted by their neural activity and the properties of the music. Given the large amount of noise, non-stationarity, and non-linearity in both EEG and music, this is an encouraging result. Additionally, the combination of measures of brain activity and acoustic features describing the music played to our participants allows us to predict music-induced emotions with significantly higher accuracies than either feature type alone (p<0.01). PMID:26544602

  5. The analysis of solar activity features by means of the BASIS digital imaging system

    NASA Astrophysics Data System (ADS)

    Messerotti, M.; Lampi, L.; Furlani, S.; Zlobec, P.

    CCD-based digital imaging systems are powerful tools for the analysis of solar activity features in real-time or as post-processing. Despite the actual sensor-limited resolutions of low-cost systems, interesting projects can be carried out such as, for instance, the tracing of photospheric motions, in principle also in automatic mode. With regard to that BASIS, a digital imaging system for the sun operated at Trieste, will be briefly described. Possible applications as mentioned above will be discussed with emphasis on photospheric and chromospheric patterns.

  6. Heap/stack guard pages using a wakeup unit

    DOEpatents

    Gooding, Thomas M; Satterfield, David L; Steinmacher-Burow, Burkhard

    2014-04-29

    A method and system for providing a memory access check on a processor including the steps of detecting accesses to a memory device including level-1 cache using a wakeup unit. The method includes invalidating level-1 cache ranges corresponding to a guard page, and configuring a plurality of wakeup address compare (WAC) registers to allow access to selected WAC registers. The method selects one of the plurality of WAC registers, and sets up a WAC register related to the guard page. The method configures the wakeup unit to interrupt on access of the selected WAC register. The method detects access of the memory device using the wakeup unit when a guard page is violated. The method generates an interrupt to the core using the wakeup unit, and determines the source of the interrupt. The method detects the activated WAC registers assigned to the violated guard page, and initiates a response.

  7. Interstellar Initiative Web Page Design

    NASA Technical Reports Server (NTRS)

    Mehta, Alkesh

    1999-01-01

    This summer at NASA/MSFC, I have contributed to two projects: Interstellar Initiative Web Page Design and Lenz's Law Relative Motion Demonstration. In the Web Design Project, I worked on an Outline. The Web Design Outline was developed to provide a foundation for a Hierarchy Tree Structure. The Outline would help design a Website information base for future and near-term missions. The Website would give in-depth information on Propulsion Systems and Interstellar Travel. The Lenz's Law Relative Motion Demonstrator is discussed in this volume by Russell Lee.

  8. Interstellar Initiative Web Page Design

    NASA Astrophysics Data System (ADS)

    Mehta, Alkesh

    1999-10-01

    This summer at NASA/MSFC, I have contributed to two projects: Interstellar Initiative Web Page Design and Lenz's Law Relative Motion Demonstration. In the Web Design Project, I worked on an Outline. The Web Design Outline was developed to provide a foundation for a Hierarchy Tree Structure. The Outline would help design a Website information base for future and near-term missions. The Website would give in-depth information on Propulsion Systems and Interstellar Travel. The Lenz's Law Relative Motion Demonstrator is discussed in this volume by Russell Lee.

  9. Joint spatial-spectral feature space clustering for speech activity detection from ECoG signals.

    PubMed

    Kanas, Vasileios G; Mporas, Iosif; Benz, Heather L; Sgarbas, Kyriakos N; Bezerianos, Anastasios; Crone, Nathan E

    2014-04-01

    Brain-machine interfaces for speech restoration have been extensively studied for more than two decades. The success of such a system will depend in part on selecting the best brain recording sites and signal features corresponding to speech production. The purpose of this study was to detect speech activity automatically from electrocorticographic signals based on joint spatial-frequency clustering of the ECoG feature space. For this study, the ECoG signals were recorded while a subject performed two different syllable repetition tasks. We found that the optimal frequency resolution to detect speech activity from ECoG signals was 8 Hz, achieving 98.8% accuracy by employing support vector machines as a classifier. We also defined the cortical areas that held the most information about the discrimination of speech and nonspeech time intervals. Additionally, the results shed light on the distinct cortical areas associated with the two syllables repetition tasks and may contribute to the development of portable ECoG-based communication.

  10. The features of longitudinal distribution of solar spots during the last 13 solar activity minima

    NASA Astrophysics Data System (ADS)

    Kostuchenko, I. G.; Benevolenskaya, E. E.

    2015-12-01

    We analyzed the features of the longitudinal distribution of the areas of solar spots during the solar activity minima, from the 11th cycle to the last minimum, based on data provided by the Greenwich Observatory and the Marshall Research Center. We discovered that the solar spots evolved in one or two neighboring bands (in terms of longitude), the Carrington longitude of which smoothly displaced from the east to the west, in the phase of the deep minimum in all of the considered cases. The spots at the high latitudes associated with a "new" cycle evolved on the same longitude bands. All of this led to the noticeable longitudinal asymmetry of magnetic fluxes related to the spots and flocculi. Based on our research, we propose the hypothesis that a nonaxisymmetric component of the total magnetic flux of the Sun is generated, together with the dipole component, by the solar dynamo mechanism, which is a typical feature of the phase of a minimum between the solar activity cycles.

  11. Genomic features of uncultured methylotrophs in activated-sludge microbiomes grown under different enrichment procedures.

    PubMed

    Fujinawa, Kazuki; Asai, Yusuke; Miyahara, Morio; Kouzuma, Atsushi; Abe, Takashi; Watanabe, Kazuya

    2016-01-01

    Methylotrophs are organisms that are able to grow on C1 compounds as carbon and energy sources. They play important roles in the global carbon cycle and contribute largely to industrial wastewater treatment. To identify and characterize methylotrophs that are involved in methanol degradation in wastewater-treatment plants, methanol-fed activated-sludge (MAS) microbiomes were subjected to phylogenetic and metagenomic analyses, and genomic features of dominant methylotrophs in MAS were compared with those preferentially grown in laboratory enrichment cultures (LECs). These analyses consistently indicate that Hyphomicrobium plays important roles in MAS, while Methylophilus occurred predominantly in LECs. Comparative analyses of bin genomes reconstructed for the Hyphomicrobium and Methylophilus methylotrophs suggest that they have different C1-assimilation pathways. In addition, function-module analyses suggest that their cell-surface structures are different. Comparison of the MAS bin genome with genomes of closely related Hyphomicrobium isolates suggests that genes unnecessary in MAS (for instance, genes for anaerobic respiration) have been lost from the genome of the dominant methylotroph. We suggest that genomic features and coded functions in the MAS bin genome provide us with insights into how this methylotroph adapts to activated-sludge ecosystems. PMID:27221669

  12. Genomic features of uncultured methylotrophs in activated-sludge microbiomes grown under different enrichment procedures

    PubMed Central

    Fujinawa, Kazuki; Asai, Yusuke; Miyahara, Morio; Kouzuma, Atsushi; Abe, Takashi; Watanabe, Kazuya

    2016-01-01

    Methylotrophs are organisms that are able to grow on C1 compounds as carbon and energy sources. They play important roles in the global carbon cycle and contribute largely to industrial wastewater treatment. To identify and characterize methylotrophs that are involved in methanol degradation in wastewater-treatment plants, methanol-fed activated-sludge (MAS) microbiomes were subjected to phylogenetic and metagenomic analyses, and genomic features of dominant methylotrophs in MAS were compared with those preferentially grown in laboratory enrichment cultures (LECs). These analyses consistently indicate that Hyphomicrobium plays important roles in MAS, while Methylophilus occurred predominantly in LECs. Comparative analyses of bin genomes reconstructed for the Hyphomicrobium and Methylophilus methylotrophs suggest that they have different C1-assimilation pathways. In addition, function-module analyses suggest that their cell-surface structures are different. Comparison of the MAS bin genome with genomes of closely related Hyphomicrobium isolates suggests that genes unnecessary in MAS (for instance, genes for anaerobic respiration) have been lost from the genome of the dominant methylotroph. We suggest that genomic features and coded functions in the MAS bin genome provide us with insights into how this methylotroph adapts to activated-sludge ecosystems. PMID:27221669

  13. Seachable Solar Feature Catalogues in EGSO

    NASA Astrophysics Data System (ADS)

    Zharkova, V. V.; Aboudarham, J.; Zharkov, S. I.; Ipson, S. S.; Benkhalil, A. K.; Fuller, N.

    2004-12-01

    The searchable Solar Feature Catalogues (SFC) developed using automated pattern recognition techniques from digitized solar images are presented. The techniques were applied for detection of sunspots, active regions, filaments and line-on-sight magnetic neutral lines in the automatically standardized full disk solar images in Ca II K1, Ca II K3 and Ha taken at the Meudon Observatory and white light images and magnetograms from SOHO/MDI. The results of automated recognition were verified with the manual synoptic maps and available statistical data that revealed good detection accuracy. Based on the recognized parameters a structured database of the Solar Feature Catalogues was built on a mysql server for every feature and published with various pre-designed search pages on the Bradford University web site. The SFCs with 10 year coverage (1996-2005) is to be used for deeper investigation of the solar activity, activity feature classification and forecast.

  14. Relationship between the latest activity of mare volcanism and topographic features of the Moon

    NASA Astrophysics Data System (ADS)

    Kato, Shinsuke; Morota, Tomokatsu; Yamaguchi, Yasushi; Watanabe, Sei-ichiro; Otake, Hisashi; Ohtake, Makiko

    2016-04-01

    Lunar mare basalts provide insights into compositions and thermal history of lunar mantle. According to crater counting analysis with remote sensing data, the model ages of mare basalt units indicate a second peak of magma activity at the end of mare volcanism (~2 Ga), and the latest eruptions were limited in the Procellarum KREEP Terrane (PKT), which has high abundances of heat-producing elements. In order to understand the mechanism for causing the second peak and its magma source, we examined the correlation between the titanium contents and eruption ages of mare basalt units using compositional and chronological data updated by SELENE/Kaguya. Although no systematic relationship is observed globally, a rapid increase in mean titanium (Ti) content occurred at 2.3 Ga in the PKT, suggesting that the magma source of mare basalts changed at that time. The high-Ti basaltic eruption, which occurred at the late stage of mare volcanism, can be correlated with the second peak of volcanic activity at ~2 Ga. The latest volcanic activity can be explained by a high-Ti hot plume originated from the core-mantle boundary. If the hot plume was occurred, the topographic features formed by the hot plume may be remained. We calculated the difference between topography and selenoid and found the circular feature like a plateau in the center of the PKT, which scale is ~1000 km horizontal and ~500 m vertical. We investigated the timing of ridge formation in the PKT by using stratigraphic relationship between mare basalts and ridges. The ridges were formed before and after the high-Ti basaltic eruptions and seem to be along with the plateau. These results suggest that the plateau formation is connected with the high-Ti basaltic eruptions.

  15. Frequencies, Laboratory Features, and Granulocyte Activation in Chinese Patients with CALR-Mutated Myeloproliferative Neoplasms

    PubMed Central

    Tian, Ruiyuan; Chang, Jianmei; Li, Jianlan; Tan, Yanhong; Xu, Zhifang; Ren, Fanggang; Zhao, Junxia; Pan, Jie; Zhang, Na; Wang, Xiaojuan; He, Jianxia; Yang, Wanfang; Wang, Hongwei

    2015-01-01

    Somatic mutations in the CALR gene have been recently identified as acquired alterations in myeloproliferative neoplasms (MPNs). In this study, we evaluated mutation frequencies, laboratory features, and granulocyte activation in Chinese patients with MPNs. A combination of qualitative allele-specific polymerase chain reaction and Sanger sequencing was used to detect three driver mutations (i.e., CALR, JAK2V617F, and MPL). CALR mutations were identified in 8.4% of cases with essential thrombocythemia (ET) and 5.3% of cases with primary myelofibrosis (PMF). Moreover, 25% of polycythemia vera, 29.5% of ET, and 48.1% of PMF were negative for all three mutations (JAK2V617F, MPL, and CALR). Compared with those patients with JAK2V617F mutation, CALR-mutated ET patients displayed unique hematological phenotypes, including higher platelet counts, and lower leukocyte counts and hemoglobin levels. Significant differences were not found between Chinese PMF patients with mutants CALR and JAK2V617F in terms of laboratory features. Interestingly, patients with CALR mutations showed markedly decreased levels of leukocyte alkaline phosphatase (LAP) expression, whereas those with JAK2V617F mutation presented with elevated levels. Overall, a lower mutant rate of CALR gene and a higher triple-negative rate were identified in the cohort of Chinese patients with MPNs. This result indicates that an undiscovered mutant gene may have a significant role in these patients. Moreover, these pathological features further imply that the disease biology varies considerably between mutants CALR and JAK2V617F. PMID:26375990

  16. Microscopic and mesoscopic structural features of an activated carbon sample, prepared from sorghum via activation by phosphoric acid

    SciTech Connect

    Temleitner, László; Pusztai, László; Rubio-Arroyo, Manuel F.; Aguilar-López, Sergio; Pizio, Orest

    2012-12-15

    Graphical abstract: Display Omitted Highlights: ► Preparation of a new activated carbon sample from sorghum. ► Characterization by adsorption/desorption methods. ► Determination of the structure by synchrotron X-ray diffraction. ► The sample is amorphous and contains distorted graphene fragments. ► A characteristic nanoscale distance is established from the radial distribution function. -- Abstract: An acidic chemical activation procedure has been used for preparing activated carbon with a surface area exceeding 1000 m{sup 2}/g from sorghum. In order to reveal structural features, synchrotron X-ray diffraction measurements have been performed. The structure of the material has been characterized by the total scattering structure factor and the radial distribution function describing short-range arrangement of atoms at distances of the order of a few atomic diameters as well as correlations at a longer scale, of the order of nanometers. The atomic arrangement has been found to be consistent with that of amorphous graphite-like carbon. As far as the mesoscopic structure is concerned, the presence of a characteristic distance is suggested on the basis of the clear nanometer scale oscillations of the radial distribution function, which distance may be assigned as the mesopore size in the material. It is suggested that the approach devized here may later be applied routinely for other activated carbon samples, too, for characterizing atomic and nanoscale order simultaneously.

  17. An efficient scheme for automatic web pages categorization using the support vector machine

    NASA Astrophysics Data System (ADS)

    Bhalla, Vinod Kumar; Kumar, Neeraj

    2016-07-01

    In the past few years, with an evolution of the Internet and related technologies, the number of the Internet users grows exponentially. These users demand access to relevant web pages from the Internet within fraction of seconds. To achieve this goal, there is a requirement of an efficient categorization of web page contents. Manual categorization of these billions of web pages to achieve high accuracy is a challenging task. Most of the existing techniques reported in the literature are semi-automatic. Using these techniques, higher level of accuracy cannot be achieved. To achieve these goals, this paper proposes an automatic web pages categorization into the domain category. The proposed scheme is based on the identification of specific and relevant features of the web pages. In the proposed scheme, first extraction and evaluation of features are done followed by filtering the feature set for categorization of domain web pages. A feature extraction tool based on the HTML document object model of the web page is developed in the proposed scheme. Feature extraction and weight assignment are based on the collection of domain-specific keyword list developed by considering various domain pages. Moreover, the keyword list is reduced on the basis of ids of keywords in keyword list. Also, stemming of keywords and tag text is done to achieve a higher accuracy. An extensive feature set is generated to develop a robust classification technique. The proposed scheme was evaluated using a machine learning method in combination with feature extraction and statistical analysis using support vector machine kernel as the classification tool. The results obtained confirm the effectiveness of the proposed scheme in terms of its accuracy in different categories of web pages.

  18. The neural organization of semantic memory: Electrophysiological activity suggests feature-based segregation

    PubMed Central

    Sitnikova, Tatiana; West, W. Caroline; Kuperberg, Gina R.; Holcomb, Phillip J.

    2007-01-01

    Despite decades of research, it remains controversial whether semantic knowledge is anatomically segregated in the human brain. To address this question, we recorded event-related potentials (ERPs) while participants viewed pictures of animals and tools. Within the 200–600-ms epoch after stimulus presentation, animals (relative to tools) elicited an increased anterior negativity that, based on previous ERP studies, we interpret as associated with semantic processing of visual object attributes. In contrast, tools (relative to animals) evoked an enhanced posterior left-lateralized negativity that, according to prior research, might reflect accessing knowledge of characteristic motion and/or more general functional properties of objects. These results support the hypothesis of the neuroanatomical knowledge organization at the level of object features: the observed neurophysiological activity was modulated by the features that were most salient for object recognition. The high temporal resolution of ERPs allowed us to demonstrate that differences in processing animals and tools occurred specifically within the time-window encompassing semantic analysis. PMID:16129544

  19. Features of the electronic structure of the active center of an HbS molecule

    NASA Astrophysics Data System (ADS)

    Novoselov, D. Yu.; Korotin, Dm. M.; Anisimov, V. I.

    2016-01-01

    Features of the electronic structure of the nonprotein part of the mutant form of the human hemoglobin molecule, HbS, are studied along with the magnetic state of the iron ion that is the "nucleus" of the active center of the molecule. It is found that the mutant form of the HbS molecule differs from a normal hemoglobin molecule by the distortion of the local environment of the iron ion, which changes the energy level splitting by a crystal field. As a result of ab initio calculations, the magnetic transition in the iron atom from the high-spin state to the low-spin state upon the addition of molecular oxygen to hemoglobin molecule is reproduced. It is established for the first time that a change in the crystal and electronic structure of the active center as a result of a mutation can lead to a substantial change in the energy of the bond between the active center of the hemoglobin molecule and an oxygen molecule.

  20. Image sensor innovations for low light levels with active imaging features

    NASA Astrophysics Data System (ADS)

    Powell, Gareth H.; Fereyre, Pierre

    2015-02-01

    Advances in CMOS imaging enable image capture at lower light levels. Color detection is also possible where human vision becomes less sensitive in night conditions. In daytime conditions, there are a number of climatic conditions such as rain, fog, snow or smoke etc. that render traditional `intelligent' outdoor cameras that perform various forms of detection and identification tasks relatively ineffective. It has been proven that an adapted five transistor pixel CMOS sensor can perform range-gated active imaging that extends considerably the usability of intelligent cameras in the most difficult conditions. This paper discusses advanced state of the art image sensors with embedded features, with emphasis on the everimportant size, weight, power and cost benefits and discusses the new applications that are enabled.

  1. Feature selection for wearable smartphone-based human activity recognition with able bodied, elderly, and stroke patients.

    PubMed

    Capela, Nicole A; Lemaire, Edward D; Baddour, Natalie

    2015-01-01

    Human activity recognition (HAR), using wearable sensors, is a growing area with the potential to provide valuable information on patient mobility to rehabilitation specialists. Smartphones with accelerometer and gyroscope sensors are a convenient, minimally invasive, and low cost approach for mobility monitoring. HAR systems typically pre-process raw signals, segment the signals, and then extract features to be used in a classifier. Feature selection is a crucial step in the process to reduce potentially large data dimensionality and provide viable parameters to enable activity classification. Most HAR systems are customized to an individual research group, including a unique data set, classes, algorithms, and signal features. These data sets are obtained predominantly from able-bodied participants. In this paper, smartphone accelerometer and gyroscope sensor data were collected from populations that can benefit from human activity recognition: able-bodied, elderly, and stroke patients. Data from a consecutive sequence of 41 mobility tasks (18 different tasks) were collected for a total of 44 participants. Seventy-six signal features were calculated and subsets of these features were selected using three filter-based, classifier-independent, feature selection methods (Relief-F, Correlation-based Feature Selection, Fast Correlation Based Filter). The feature subsets were then evaluated using three generic classifiers (Naïve Bayes, Support Vector Machine, j48 Decision Tree). Common features were identified for all three populations, although the stroke population subset had some differences from both able-bodied and elderly sets. Evaluation with the three classifiers showed that the feature subsets produced similar or better accuracies than classification with the entire feature set. Therefore, since these feature subsets are classifier-independent, they should be useful for developing and improving HAR systems across and within populations.

  2. Feature selection for wearable smartphone-based human activity recognition with able bodied, elderly, and stroke patients.

    PubMed

    Capela, Nicole A; Lemaire, Edward D; Baddour, Natalie

    2015-01-01

    Human activity recognition (HAR), using wearable sensors, is a growing area with the potential to provide valuable information on patient mobility to rehabilitation specialists. Smartphones with accelerometer and gyroscope sensors are a convenient, minimally invasive, and low cost approach for mobility monitoring. HAR systems typically pre-process raw signals, segment the signals, and then extract features to be used in a classifier. Feature selection is a crucial step in the process to reduce potentially large data dimensionality and provide viable parameters to enable activity classification. Most HAR systems are customized to an individual research group, including a unique data set, classes, algorithms, and signal features. These data sets are obtained predominantly from able-bodied participants. In this paper, smartphone accelerometer and gyroscope sensor data were collected from populations that can benefit from human activity recognition: able-bodied, elderly, and stroke patients. Data from a consecutive sequence of 41 mobility tasks (18 different tasks) were collected for a total of 44 participants. Seventy-six signal features were calculated and subsets of these features were selected using three filter-based, classifier-independent, feature selection methods (Relief-F, Correlation-based Feature Selection, Fast Correlation Based Filter). The feature subsets were then evaluated using three generic classifiers (Naïve Bayes, Support Vector Machine, j48 Decision Tree). Common features were identified for all three populations, although the stroke population subset had some differences from both able-bodied and elderly sets. Evaluation with the three classifiers showed that the feature subsets produced similar or better accuracies than classification with the entire feature set. Therefore, since these feature subsets are classifier-independent, they should be useful for developing and improving HAR systems across and within populations. PMID:25885272

  3. "I didn't know her, but…": parasocial mourning of mediated deaths on Facebook RIP pages

    NASA Astrophysics Data System (ADS)

    Klastrup, Lisbeth

    2015-04-01

    This article examines the use of six Danish "Rest in Peace" or (RIP) memorial pages. The article focuses on the relation between news media and RIP page use, in relation to general communicative practices on these pages. Based on an analysis of press coverage of the deaths of six young people and a close analysis of 1,015 comments extracted from the RIP pages created to memorialize them, it is shown that their deaths attracted considerable media attention, as did the RIP pages themselves. Comment activity seem to reflect the news stories in the way the commenters refer to the context of death and the emotional distress they experience, but mainly comments on the RIP pages are conventional expressions of sympathy and "RIP" wishes. The article concludes that public RIP pages might be understood as virtual spontaneous shrines, affording an emerging practice of "RIP-ing."

  4. Combining EEG Microstates with fMRI Structural Features for Modeling Brain Activity.

    PubMed

    Michalopoulos, Kostas; Bourbakis, Nikolaos

    2015-12-01

    Combining information from Electroencephalography (EEG) and Functional Magnetic Resonance Imaging (fMRI) has been a topic of increased interest recently. The main advantage of the EEG is its high temporal resolution, in the scale of milliseconds, while the main advantage of fMRI is the detection of functional activity with good spatial resolution. The advantages of each modality seem to complement each other, providing better insight in the neuronal activity of the brain. The main goal of combining information from both modalities is to increase the spatial and the temporal localization of the underlying neuronal activity captured by each modality. This paper presents a novel technique based on the combination of these two modalities (EEG, fMRI) that allow a better representation and understanding of brain activities in time. EEG is modeled as a sequence of topographies, based on the notion of microstates. Hidden Markov Models (HMMs) were used to model the temporal evolution of the topography of the average Event Related Potential (ERP). For each model the Fisher score of the sequence is calculated by taking the gradient of the trained model parameters. The Fisher score describes how this sequence deviates from the learned HMM. Canonical Partial Least Squares (CPLS) were used to decompose the two datasets and fuse the EEG and fMRI features. In order to test the effectiveness of this method, the results of this methodology were compared with the results of CPLS using the average ERP signal of a single channel. The presented methodology was able to derive components that co-vary between EEG and fMRI and present significant differences between the two tasks.

  5. Combining EEG Microstates with fMRI Structural Features for Modeling Brain Activity.

    PubMed

    Michalopoulos, Kostas; Bourbakis, Nikolaos

    2015-12-01

    Combining information from Electroencephalography (EEG) and Functional Magnetic Resonance Imaging (fMRI) has been a topic of increased interest recently. The main advantage of the EEG is its high temporal resolution, in the scale of milliseconds, while the main advantage of fMRI is the detection of functional activity with good spatial resolution. The advantages of each modality seem to complement each other, providing better insight in the neuronal activity of the brain. The main goal of combining information from both modalities is to increase the spatial and the temporal localization of the underlying neuronal activity captured by each modality. This paper presents a novel technique based on the combination of these two modalities (EEG, fMRI) that allow a better representation and understanding of brain activities in time. EEG is modeled as a sequence of topographies, based on the notion of microstates. Hidden Markov Models (HMMs) were used to model the temporal evolution of the topography of the average Event Related Potential (ERP). For each model the Fisher score of the sequence is calculated by taking the gradient of the trained model parameters. The Fisher score describes how this sequence deviates from the learned HMM. Canonical Partial Least Squares (CPLS) were used to decompose the two datasets and fuse the EEG and fMRI features. In order to test the effectiveness of this method, the results of this methodology were compared with the results of CPLS using the average ERP signal of a single channel. The presented methodology was able to derive components that co-vary between EEG and fMRI and present significant differences between the two tasks. PMID:26584584

  6. Using Citizen Scientists to Gather, Analyze, and Disseminate Information About Neighborhood Features That Affect Active Living.

    PubMed

    Winter, Sandra J; Goldman Rosas, Lisa; Padilla Romero, Priscilla; Sheats, Jylana L; Buman, Matthew P; Baker, Cathleen; King, Abby C

    2016-10-01

    Many Latinos are insufficiently active, partly due to neighborhoods with little environmental support for physical activity. Multi-level approaches are needed to create health-promoting neighborhoods in disadvantaged communities. Participant "citizen scientists" were adolescent (n = 10, mean age = 12.8 ± 0.6 years) and older adult (n = 10, mean age = 71.3 ± 6.5 years), low income Latinos in North Fair Oaks, California. Citizen scientists conducted environmental assessments to document perceived barriers to active living using the Stanford Healthy Neighborhood Discovery Tool, which records GPS-tracked walking routes, photographs, audio narratives, and survey responses. Using a community-engaged approach, citizen scientists subsequently attended a community meeting to engage in advocacy training, review assessment data, prioritize issues to address and brainstorm potential solutions and partners. Citizen scientists each conducted a neighborhood environmental assessment and recorded 366 photographs and audio narratives. Adolescents (n = 4), older adults (n = 7) and community members (n = 4) collectively identified reducing trash and improving personal safety and sidewalk quality as the priority issues to address. Three adolescent and four older adult citizen scientists volunteered to present study findings to key stakeholders. This study demonstrated that with minimal training, low-income, Latino adolescent and older adult citizen scientists can: (1) use innovative technology to gather information about features of their neighborhood environment that influence active living, (2) analyze their information and identify potential solutions, and (3) engage with stakeholders to advocate for the development of healthier neighborhoods.

  7. Premature skin aging features rescued by inhibition of NADPH oxidase activity in XPC-deficient mice.

    PubMed

    Hosseini, Mohsen; Mahfouf, Walid; Serrano-Sanchez, Martin; Raad, Houssam; Harfouche, Ghida; Bonneu, Marc; Claverol, Stephane; Mazurier, Frederic; Rossignol, Rodrigue; Taieb, Alain; Rezvani, Hamid Reza

    2015-04-01

    Xeroderma pigmentosum type C (XP-C) is characterized mostly by a predisposition to skin cancers and accelerated photoaging, but little is known about premature skin aging in this disease. By comparing young and old mice, we found that the level of progerin and p16(INK4a) expression, β-galactosidase activity, and reactive oxygen species, which increase with age, were higher in young Xpc(-/-) mice than in young Xpc(+/+) ones. The expression level of mitochondrial complexes and mitochondrial functions in the skin of young Xpc(-/-) was as low as in control aged Xpc(+/+)animals. Furthermore, the metabolic profile in young Xpc(-/-) mice resembled that found in aged Xpc(+/+) mice. Furthermore, premature skin aging features in young Xpc(-/-) mice were mostly rescued by inhibition of nicotinamide adenine dinucleotide phosphate oxidase 1 (NOX1) activity by using a NOX1 peptide inhibitor, suggesting that the continuous oxidative stress due to overactivation of NOX1 has a causative role in the underlying pathophysiology. PMID:25437426

  8. Structural features of endocrine active chemicals--A comparison of in vivo and in vitro data.

    PubMed

    Lewin, Geertje; Escher, Sylvia E; van der Burg, Bart; Simetska, Nelly; Mangelsdorf, Inge

    2015-08-01

    Studies on reproductive toxicity need high numbers of test animals. Therefore, we investigated whether chemical structural features (SF) in combination with in vitro data on specific adverse outcome pathways (AOPs) may be used for predicting reproductive toxicity of untested chemicals. Using the OECD Toolbox and expert judgment, we identified 89 structure groups for 275 chemicals for which the results of prenatal developmental toxicity or multigeneration studies were present in the Fraunhofer database on Fertility and Developmental Toxicity in experimental animals (FeDTex) database. Likewise, we evaluated 220 chemicals which had been tested in reporter gene assays on endocrine ((anti)estrogenic and (anti)androgenic) properties in the CALUX(®) test battery. There was a large spread of effect levels for substances within the chemical structure groups for both, in vivo and in vitro results. The groups of highest concern (diphenyl derivatives, planar conjugated systems with fused rings, phenols and organophosphates) correlated quite well, however, between the in vivo and in vitro data on estrogenic activity. For the 56 chemicals represented in both databases, lowest effect doses in vivo correlated well with the estrogenic activity in vitro. These results suggest that a panel of assays covering relevant AOPs and data on metabolism and toxicokinetics may allow prediction of relative reproductive or development toxicity potency within the identified chemical structure groups.

  9. A new irradiation plant in Italy: Technical features and activities performed

    NASA Astrophysics Data System (ADS)

    Tata, A.; Casali, F.; Schwarz, M.

    1998-06-01

    Since 1995, a new Hitesys Co. pilot/industrial irradiation plant has been operating in Aprilia, 50 km south of Rome. The plant, which was jointly designed by ENEA and Hitesys Co., is equipped with a highly flexible automatic materials transport system which is also suitable for continuous process repetition or, when upturned, for double-side material treatment. The main features of the irradiation plant are: - the radiation source: EB-machine LINAC type (s band) with maximum electron beam energy of 10 MeV and beam power of 1000 W; - the bunker: external type, shielded by ordinary concrete, equipped with a suitable entrance/exit maze in order to allow easy handling and managing of materials as well as to facilitate equipment and machinery maintenance and inspection activities. An intense program of R&D activities and technological services has already been performed in relation to industrial processes and environmental applications, as well as many other radiation technology applications, including agriculture related processes.

  10. Strong Nonadditivity as a Key Structure–Activity Relationship Feature: Distinguishing Structural Changes from Assay Artifacts

    PubMed Central

    2015-01-01

    Nonadditivity in protein–ligand affinity data represents highly instructive structure–activity relationship (SAR) features that indicate structural changes and have the potential to guide rational drug design. At the same time, nonadditivity is a challenge for both basic SAR analysis as well as many ligand-based data analysis techniques such as Free-Wilson Analysis and Matched Molecular Pair analysis, since linear substituent contribution models inherently assume additivity and thus do not work in such cases. While structural causes for nonadditivity have been analyzed anecdotally, no systematic approaches to interpret and use nonadditivity prospectively have been developed yet. In this contribution, we lay the statistical framework for systematic analysis of nonadditivity in a SAR series. First, we develop a general metric to quantify nonadditivity. Then, we demonstrate the non-negligible impact of experimental uncertainty that creates apparent nonadditivity, and we introduce techniques to handle experimental uncertainty. Finally, we analyze public SAR data sets for strong nonadditivity and use recourse to the original publications and available X-ray structures to find structural explanations for the nonadditivity observed. We find that all cases of strong nonadditivity (ΔΔpKi and ΔΔpIC50 > 2.0 log units) with sufficient structural information to generate reasonable hypothesis involve changes in binding mode. With the appropriate statistical basis, nonadditivity analysis offers a variety of new attempts for various areas in computer-aided drug design, including the validation of scoring functions and free energy perturbation approaches, binding pocket classification, and novel features in SAR analysis tools. PMID:25760829

  11. Finding Specification Pages from the Web

    NASA Astrophysics Data System (ADS)

    Yoshinaga, Naoki; Torisawa, Kentaro

    This paper presents a method of finding a specification page on the Web for a given object (e.g., ``Ch. d'Yquem'') and its class label (e.g., ``wine''). A specification page for an object is a Web page which gives concise attribute-value information about the object (e.g., ``county''-``Sauternes'') in well formatted structures. A simple unsupervised method using layout and symbolic decoration cues was applied to a large number of the Web pages to acquire candidate attributes for each class (e.g., ``county'' for a class ``wine''). We then filter out irrelevant words from the putative attributes through an author-aware scoring function that we called site frequency. We used the acquired attributes to select a representative specification page for a given object from the Web pages retrieved by a normal search engine. Experimental results revealed that our system greatly outperformed the normal search engine in terms of this specification retrieval.

  12. Realistic page-turning of electronic books

    NASA Astrophysics Data System (ADS)

    Fan, Chaoran; Li, Haisheng; Bai, Yannan

    2014-01-01

    The booming electronic books (e-books), as an extension to the paper book, are popular with readers. Recently, many efforts are put into the realistic page-turning simulation o f e-book to improve its reading experience. This paper presents a new 3D page-turning simulation approach, which employs piecewise time-dependent cylindrical surfaces to describe the turning page and constructs smooth transition method between time-dependent cylinders. The page-turning animation is produced by sequentially mapping the turning page into the cylinders with different radii and positions. Compared to the previous approaches, our method is able to imitate various effects efficiently and obtains more natural animation of turning page.

  13. The luminous polycyclic aromatic hydrocarbon emission features: Applications to high redshift galaxies and active galactic nuclei

    NASA Astrophysics Data System (ADS)

    Shipley, Heath Vernon

    (corrected for attenuation using the mono-chromatic rest-frame 24um emission), with a tight scatter of 0.15 dex. The scatter is comparable to that between SFRs derived from the Paalpha and dust-corrected Halpha emission lines, implying the PAH features may be as accurate a SFR indicator as the Hydrogen recombination lines. Because the PAH features are so bright, our PAH SFR calibration enables an efficient way to measure SFRs in distant galaxies with JWST to SFRs as low as ~10 M; yr-1 to z >~ 2. We use Spitzer/IRS observations of PAH features in lensed star-forming galaxies at 1 < z < 3 to demonstrate the utility of the PAHs to derive SFRs as accurate as those available from Paalpha. Chapter 4 is the application of the PAH SFRs for galaxies with AGN to demonstrate the reliability for studies of the co-evolution of star-formation and SMBH accretion. We present a study of the contribution from star-formation in galaxies of varying AGN activity (from pure star-forming galaxies to quasars) as a function of total IR luminosity using a sample of 220 galaxies. We use mid-IR spectroscopy from the Spitzer/IRS and photometry from the MIPS mum, 70mum and 160mum bands with partial coverage of the sample with the Herschel 160mum band for the quasars. The contribution from star-formation to the total IR luminosity implied by the PAH emission decreases with increasing IR luminosity. We find a similar result to previous studies for the correlation between SFR, i.e. PAH luminosity, and AGN luminosity for quasars of LSF [special characters omitted] for the 11.3mum PAH feature only (which has been shown to be the most reliable PAH feature in the vicinity of AGN). This may indicate the PAH luminosity remains a reliable tracer of the SFR for galaxies with strong AGN contributions (i.e. quasars), as we did not subtract off the AGN component before measuring the SFR from the PAH luminosity.

  14. Loss of EBP50 stimulates EGFR activity to induce EMT phenotypic features in biliary cancer cells.

    PubMed

    Clapéron, A; Guedj, N; Mergey, M; Vignjevic, D; Desbois-Mouthon, C; Boissan, M; Saubaméa, B; Paradis, V; Housset, C; Fouassier, L

    2012-03-15

    Scaffold proteins form multiprotein complexes that are central to the regulation of intracellular signaling. The scaffold protein ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) is highly expressed at the plasma membrane of normal biliary epithelial cells and binds epidermal growth factor receptor (EGFR), a tyrosine kinase receptor with oncogenic properties. This study investigated EBP50-EGFR interplay in biliary cancer. We report that in a collection of 106 cholangiocarcinomas, EBP50 was delocalized to the cytoplasm of tumor cells in 66% of the cases. Ectopic expression of EBP50 was correlated with the presence of satellite nodules and with the expression of EGFR, which was at the plasma membrane, implying a loss of interaction with EBP50 in these cases. In vitro, loss of interaction between EBP50 and EGFR was mimicked by EBP50 depletion using a small interfering RNA approach in human biliary carcinoma cells co-expressing the two proteins at their plasma membrane, and in which interaction between EBP50 and EGFR was validated. EBP50 depletion caused an increase in EGFR expression at their surface, and a sustained activation of the receptor and of its downstream effectors (extracellular signal-regulated kinase 1/2, signal transducer and activator of transcription 3) in both basal and EGF-stimulated conditions. Cells lacking EBP50 showed epithelial-to-mesenchymal transition-associated features, including reduction in E-cadherin and cytokeratin-19 expression, induction of S100A4 and of the E-cadherin transcriptional repressor, Slug, and loss of cell polarity. Accordingly, depletion of EBP50 induced the disruption of adherens junctional complexes, the development of lamellipodia structures and the subsequent acquisition of motility properties. All these phenotypic changes were prevented upon inhibition of EGFR tyrosine kinase by gefitinib. These findings indicate that loss of EBP50 at the plasma membrane in tumor cells may contribute to biliary carcinogenesis

  15. Autofluorescence based visualization of proteins from unstained native-PAGE

    NASA Astrophysics Data System (ADS)

    Manjunath, S.; Rao, Bola Sadashiva S.; Satyamoorthy, Kapaettu; Mahato, Krishna Kishore

    2015-03-01

    Proteins are the most diverse and functionally active biomolecules in the living system. In order to understand their diversity and dynamic functionality, visualization in native form without altering structural and functional properties during the separation from the complex mixtures is very much essential. In the present study, a sensitive methodology for optimal visualization of unstained or untagged proteins in native poly-acrylamide gel electrophoresis (N-PAGE) has been developed where, concentration of the acrylamide and bis-acrylamide mixture, Percentage of the gel, fixing of the N-PAGE by methanol: acetic acid: water and washing of the gel in the mili-Q water has been optimized for highest sensitivity using laser induced autofluorescence. The outcome with bovine serum albumin (BSA) in PAGE was found to be highest at acrylamide and bis-acrylamide concentrations of 29.2 and 0.8 respectively in 12% N-PAGE. After the electrophoresis run, washing of the N-PAGE immediately with miliQ water for 12 times and eliminating the methanol: acetic acid: water, fixing of the N-PAGE yielded better sensitivity of visualization. Using the above methodology 25ng of BSA protein band in PAGE was clearly identified by the technique. The currently used staining techniques for the visualization of proteins are coomassie brilliant blue and silver staining, have the sensitivity of 100ng and 5ng respectively. The current methodology was found to be more sensitive as compared to coomassie staining and less sensitive compared to silver staining respectively. The added advantage of this methodology is the faster visualization of proteins without altering their structure and functional properties.

  16. Activation and maintenance of peripheral semantic features of unambiguous words after right hemisphere brain damage in adults

    PubMed Central

    Tompkins, Connie A.; Fassbinder, Wiltrud; Scharp, Victoria L.; Meigh, Kimberly M.

    2009-01-01

    Background The right cerebral hemisphere (RH) sustains activation of subordinate, secondary, less common, and/or distantly related meanings of words. Much of the pertinent data come from studies of homonyms, but some evidence also suggests that the RH has a unique maintenance function in relation to unambiguous nouns. In a divided visual field priming study, Atchley, Burgess, and Keeney (1999) reported that only left visual field/RH presentation yielded evidence of continuing activation of peripheral semantic features that were incompatible with the most common image or representation of their corresponding nouns (e.g., rotten for “apple”). Activation for weakly related features that were compatible with the dominant representation (e.g., crunchy) was sustained over time regardless of the visual field/hemisphere of initial stimulus input. Several studies report that unilateral right hemisphere brain damage (RHD) in adults affects the RH’s meaning maintenance function, but this work also has centred on homonyms, and/or more recently metonymic and metaphoric polysemous words. Aims The current investigation examined whether RHD deficits in processing secondary and/or distantly related meanings of words, typically observed in studies of homonyms, would extend to peripheral, weakly related semantic features of unambiguous nouns. Methods & Procedures Participants were 28 adults with unilateral RHD from cerebrovascular accident, and 38 adults without brain damage. Participants listened to spoken sentences that ended with an unambiguous noun. Each sentence was followed by a spoken target phoneme string. Targets included peripheral semantic features of the sentence-final noun that were either compatible or incompatible with the dominant mental images of the noun, and were presented at two intervals after that noun. A lexical decision task was used to gauge both the early activation and maintenance of activation for these weakly related semantic features. Outcomes

  17. Library links on medical school home pages.

    PubMed

    Thomas, Sheila L

    2011-01-01

    The purpose of this study was to assess the websites of American Association of Medical Colleges (AAMC)-member medical schools for the presence of library links. Sixty-one percent (n = 92) of home pages of the 150 member schools of the AAMC contain library links. For the 58 home pages not offering such links, 50 provided a pathway of two or three clicks to a library link. The absence of library links on 39% of AAMC medical school home pages indicates that the designers of those pages did not consider the library to be a primary destination for their visitors.

  18. Recurrence of Acute Page Kidney in a Renal Transplant Allograft

    PubMed Central

    Zayas, Carlos; Mulloy, Laura; Jagadeesan, Muralidharan

    2016-01-01

    Acute Page Kidney (APK) phenomenon is a rare cause of secondary hypertension, mediated by activation of renin-angiotensin-aldosterone system (RAAS). Timely intervention is of great importance to prevent any end organ damage from hypertension. We present a unique case of three episodes of APK in the same renal transplant allograft. PMID:27725836

  19. Solar Feature Catalogues In Egso

    NASA Astrophysics Data System (ADS)

    Zharkova, V. V.; Aboudarham, J.; Zharkov, S.; Ipson, S. S.; Benkhalil, A. K.; Fuller, N.

    2005-05-01

    The Solar Feature Catalogues (SFCs) are created from digitized solar images using automated pattern recognition techniques developed in the European Grid of Solar Observation (EGSO) project. The techniques were applied for detection of sunspots, active regions and filaments in the automatically standardized full-disk solar images in Caii K1, Caii K3 and Hα taken at the Meudon Observatory and white-light images and magnetograms from SOHO/MDI. The results of automated recognition are verified with the manual synoptic maps and available statistical data from other observatories that revealed high detection accuracy. A structured database of the Solar Feature Catalogues is built on the MySQL server for every feature from their recognized parameters and cross-referenced to the original observations. The SFCs are published on the Bradford University web site http://www.cyber.brad.ac.uk/egso/SFC/ with the pre-designed web pages for a search by time, size and location. The SFCs with 9 year coverage (1996 2004) provide any possible information that can be extracted from full disk digital solar images. Thus information can be used for deeper investigation of the feature origin and association with other features for their automated classification and solar activity forecast.

  20. Common features and peculiarities of the seismic activity at Phlegraean Fields, Long Valley, and Vesuvius

    USGS Publications Warehouse

    Marzocchi, W.; Vilardo, G.; Hill, D.P.; Ricciardi, G.P.; Ricco, C.

    2001-01-01

    We analyzed and compared the seismic activity that has occurred in the last two to three decades in three distinct volcanic areas: Phlegraean Fields, Italy; Vesuvius, Italy; and Long Valley, California. Our main goal is to identify and discuss common features and peculiarities in the temporal evolution of earthquake sequences that may reflect similarities and differences in the generating processes between these volcanic systems. In particular, we tried to characterize the time series of the number of events and of the seismic energy release in terms of stochastic, deterministic, and chaotic components. The time sequences from each area consist of thousands of earthquakes that allow a detailed quantitative analysis and comparison. The results obtained showed no evidence for either deterministic or chaotic components in the earthquake sequences in Long Valley caldera, which appears to be dominated by stochastic behavior. In contrast, earthquake sequences at Phlegrean Fields and Mount Vesuvius show a deterministic signal mainly consisting of a 24-hour periodicity. Our analysis suggests that the modulation in seismicity is in some way related to thermal diurnal processes, rather than luni-solar tidal effects. Independently from the process that generates these periodicities on the seismicity., it is suggested that the lack (or presence) of diurnal cycles is seismic swarms of volcanic areas could be closely linked to the presence (or lack) of magma motion.

  1. Measuring consistency of web page design and its effects on performance and satisfaction.

    PubMed

    Ozok, A A; Salvendy, G

    2000-04-01

    This study examines the methods for measuring the consistency levels of web pages and the effect of consistency on the performance and satisfaction of the world-wide web (WWW) user. For clarification, a home page is referred to as a single page that is the default page of a web site on the WWW. A web page refers to a single screen that indicates a specific address on the WWW. This study has tested a series of web pages that were mostly hyperlinked. Therefore, the term 'web page' has been adopted for the nomenclature while referring to the objects of which the features were tested. It was hypothesized that participants would perform better and be more satisfied using web pages that have consistent rather than inconsistent interface design; that the overall consistency level of an interface design would significantly correlate with the three elements of consistency, physical, communicational and conceptual consistency; and that physical and communicational consistencies would interact with each other. The hypotheses were tested in a four-group, between-subject design, with 10 participants in each group. The results partially support the hypothesis regarding error rate, but not regarding satisfaction and performance time. The results also support the hypothesis that each of the three elements of consistency significantly contribute to the overall consistency of a web page, and that physical and communicational consistencies interact with each other, while conceptual consistency does not interact with them.

  2. Creating a Facebook Page for the Seismological Society of America

    NASA Astrophysics Data System (ADS)

    Newman, S. B.

    2009-12-01

    In August, 2009 I created a Facebook “fan” page for the Seismological Society of America. We had been exploring cost-effective options for providing forums for two-way communication for some months. We knew that a number of larger technical societies had invested significant sums of money to create customized social networking sites but that a small society would need to use existing low-cost software options. The first thing I discovered when I began to set up the fan page was that an unofficial SSA Facebook group already existed, established by Steven J. Gibbons, a member in Norway. Steven had done an excellent job of posting material about SSA. Partly because of the existing group, the official SSA fan page gained fans rapidly. We began by posting information about our own activities and then added links to activities in the broader geoscience community. While much of this material also appeared on our website and in our publication, Seismological Research Letters (SRL), the tone on the FB page is different. It is less formal with more emphasis on photos and links to other sites, including our own. Fans who are active on FB see the posts as part of their social network and do not need to take the initiative to go to the SSA site. Although the goal was to provide a forum for two-way communication, our initial experience was that people were clearly reading the page but not contributing content. This appears to be case with fan pages of sister geoscience societies. FB offers some demographic information to fan site administrators. In an initial review of the demographics it appeared that fans were younger than the overall demographics of the Society. It appeared that a few of the fans are not members or even scientists. Open questions are: what content will be most useful to fans? How will the existence of the page benefit the membership as a whole? Will the page ultimately encourage two-way communication as hoped? Web 2.0 is generating a series of new

  3. Utility of passive photography to objectively audit built environment features of active transport journeys: an observational study

    PubMed Central

    2013-01-01

    Background Active transport can contribute to physical activity accumulation and improved health in adults. The built environment is an established associate of active transport behaviours; however, assessment of environmental features encountered during journeys remains challenging. The purpose of this study was to examine the utility of wearable cameras to objectively audit and quantify environmental features along work-related walking and cycling routes. Methods A convenience sample of employed adults was recruited in New Zealand, in June 2011. Participants wore a SenseCam for all journeys over three weekdays and completed travel diaries and demographic questionnaires. SenseCam images for work-related active transport journeys were coded for presence of environmental features hypothesised to be related to active transport. Differences in presence of features by transport mode and in participant-reported and SenseCam-derived journey duration were determined using two-sample tests of proportion and an independent samples t-test, respectively. Results Fifteen adults participated in the study, yielding 1749 SenseCam images from 30 work-related active transport journeys for coding. Significant differences in presence of features were found between walking and cycling journeys. Almost a quarter of images were uncodeable due to being too dark to determine features. There was a non-significant tendency for respondents to under-report their journey duration. Conclusion This study provides proof of concept for the use of the SenseCam to capture built environment data in real time that may be related to active transportation. Further work is required to test and refine coding methodologies across a range of settings, travel behaviours, and demographic groups. PMID:23575288

  4. Automated Title Page Cataloging: A Feasibility Study.

    ERIC Educational Resources Information Center

    Weibel, Stuart; And Others

    1989-01-01

    Describes the design of a prototype rule-based system for the automation of descriptive cataloging from title pages. The discussion covers the results of tests of the prototype, major impediments to automatic cataloging from title pages, and prospects for further progress. The rules implemented in the prototype are appended. (16 references)…

  5. 40 CFR 1502.7 - Page limits.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 34 2012-07-01 2012-07-01 false Page limits. 1502.7 Section 1502.7 Protection of Environment COUNCIL ON ENVIRONMENTAL QUALITY ENVIRONMENTAL IMPACT STATEMENT § 1502.7 Page limits. The text of final environmental impact statements (e.g., paragraphs (d) through (g) of §...

  6. Preventing radio-paging system tieup

    NASA Technical Reports Server (NTRS)

    Jasmin, J. P.

    1978-01-01

    Time-delay relay limits message time of emergency radio-paging system, thereby preventing inadvertent tieup. Relay is connected with telephone circuit and permits adjustable message time between 30 and 55 seconds. After that time interval, relay opens, making line free for another paging regardless of what previous caller did with his telephone.

  7. 40 CFR 1502.7 - Page limits.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Page limits. 1502.7 Section 1502.7 Protection of Environment COUNCIL ON ENVIRONMENTAL QUALITY ENVIRONMENTAL IMPACT STATEMENT § 1502.7 Page limits. The text of final environmental impact statements (e.g., paragraphs (d) through (g) of §...

  8. Autobiographical Planning and the Brain: Activation and Its Modulation by Qualitative Features.

    PubMed

    Spreng, R Nathan; Gerlach, Kathy D; Turner, Gary R; Schacter, Daniel L

    2015-11-01

    To engage in purposeful behavior, it is important to make plans, which organize subsequent actions. Most studies of planning involve "look-ahead" puzzle tasks that are unrelated to personal goals. We developed a task to assess autobiographical planning, which involves the formulation of personal plans in response to real-world goals, and examined autobiographical planning in 63 adults during fMRI scanning. Autobiographical planning was found to engage the default network, including medial-temporal lobe and midline structures, and executive control regions in lateral pFC and parietal cortex and caudate. To examine how specific qualitative features of autobiographical plans modulate neural activity, we performed parametric modulation analyses. Ratings of plan detail, novelty, temporal distance, ease of plan formulation, difficulty in goal completion, and confidence in goal accomplishment were used as covariates in six hierarchical linear regression models. This modeling procedure removed shared variance among the ratings, allowing us to determine the independent relationship between ratings of interest and trial-wise BOLD signal. We found that specific autobiographical planning, describing a detailed, achievable, and actionable planning process for attaining a clearly envisioned future, recruited both default and frontoparietal brain regions. In contrast, abstract autobiographical planning, plans that were constructed from more generalized semantic or affective representations of a less tangible and distant future, involved interactions among default, sensory perceptual, and limbic brain structures. Specific qualities of autobiographical plans are important predictors of default and frontoparietal control network engagement during plan formation and reflect the contribution of mnemonic and executive control processes to autobiographical planning.

  9. Autobiographical Planning and the Brain: Activation and Its Modulation by Qualitative Features.

    PubMed

    Spreng, R Nathan; Gerlach, Kathy D; Turner, Gary R; Schacter, Daniel L

    2015-11-01

    To engage in purposeful behavior, it is important to make plans, which organize subsequent actions. Most studies of planning involve "look-ahead" puzzle tasks that are unrelated to personal goals. We developed a task to assess autobiographical planning, which involves the formulation of personal plans in response to real-world goals, and examined autobiographical planning in 63 adults during fMRI scanning. Autobiographical planning was found to engage the default network, including medial-temporal lobe and midline structures, and executive control regions in lateral pFC and parietal cortex and caudate. To examine how specific qualitative features of autobiographical plans modulate neural activity, we performed parametric modulation analyses. Ratings of plan detail, novelty, temporal distance, ease of plan formulation, difficulty in goal completion, and confidence in goal accomplishment were used as covariates in six hierarchical linear regression models. This modeling procedure removed shared variance among the ratings, allowing us to determine the independent relationship between ratings of interest and trial-wise BOLD signal. We found that specific autobiographical planning, describing a detailed, achievable, and actionable planning process for attaining a clearly envisioned future, recruited both default and frontoparietal brain regions. In contrast, abstract autobiographical planning, plans that were constructed from more generalized semantic or affective representations of a less tangible and distant future, involved interactions among default, sensory perceptual, and limbic brain structures. Specific qualities of autobiographical plans are important predictors of default and frontoparietal control network engagement during plan formation and reflect the contribution of mnemonic and executive control processes to autobiographical planning. PMID:26102226

  10. Monoaminergic tone supports conductance correlations and stabilizes activity features in pattern generating neurons of the lobster, Panulirus interruptus.

    PubMed

    Krenz, Wulf-Dieter; Parker, Anna R; Rodgers, Edmund; Baro, Deborah J

    2015-01-01

    Experimental and computational studies demonstrate that different sets of intrinsic and synaptic conductances can give rise to equivalent activity patterns. This is because the balance of conductances, not their absolute values, defines a given activity feature. Activity-dependent feedback mechanisms maintain neuronal conductance correlations and their corresponding activity features. This study demonstrates that tonic nM concentrations of monoamines enable slow, activity-dependent processes that can maintain a correlation between the transient potassium current (I(A) and the hyperpolarization activated current (Ih) over the long-term (i.e., regulatory change persists for hours after removal of modulator). Tonic 5 nM DA acted through an RNA interference silencing complex (RISC)- and RNA polymerase II-dependent mechanism to maintain a long-term positive correlation between I(A) and Ih in the lateral pyloric neuron (LP) but not in the pyloric dilator neuron (PD). In contrast, tonic 5 nM 5HT maintained a RISC-dependent positive correlation between I(A) and Ih in PD but not LP over the long-term. Tonic 5 nM OCT maintained a long-term negative correlation between I(A) and Ih in PD but not LP; however, it was only revealed when RISC was inhibited. This study also demonstrated that monoaminergic tone can also preserve activity features over the long-term: the timing of LP activity, LP duty cycle and LP spike number per burst were maintained by tonic 5 nM DA. The data suggest that low-level monoaminergic tone acts through multiple slow processes to permit cell-specific, activity-dependent regulation of ionic conductances to maintain conductance correlations and their corresponding activity features over the long-term. PMID:26539083

  11. Monoaminergic tone supports conductance correlations and stabilizes activity features in pattern generating neurons of the lobster, Panulirus interruptus

    PubMed Central

    Krenz, Wulf-Dieter; Parker, Anna R.; Rodgers, Edmund; Baro, Deborah J.

    2015-01-01

    Experimental and computational studies demonstrate that different sets of intrinsic and synaptic conductances can give rise to equivalent activity patterns. This is because the balance of conductances, not their absolute values, defines a given activity feature. Activity-dependent feedback mechanisms maintain neuronal conductance correlations and their corresponding activity features. This study demonstrates that tonic nM concentrations of monoamines enable slow, activity-dependent processes that can maintain a correlation between the transient potassium current (IA) and the hyperpolarization activated current (Ih) over the long-term (i.e., regulatory change persists for hours after removal of modulator). Tonic 5 nM DA acted through an RNA interference silencing complex (RISC)- and RNA polymerase II-dependent mechanism to maintain a long-term positive correlation between IA and Ih in the lateral pyloric neuron (LP) but not in the pyloric dilator neuron (PD). In contrast, tonic 5 nM 5HT maintained a RISC-dependent positive correlation between IA and Ih in PD but not LP over the long-term. Tonic 5 nM OCT maintained a long-term negative correlation between IA and Ih in PD but not LP; however, it was only revealed when RISC was inhibited. This study also demonstrated that monoaminergic tone can also preserve activity features over the long-term: the timing of LP activity, LP duty cycle and LP spike number per burst were maintained by tonic 5 nM DA. The data suggest that low-level monoaminergic tone acts through multiple slow processes to permit cell-specific, activity-dependent regulation of ionic conductances to maintain conductance correlations and their corresponding activity features over the long-term. PMID:26539083

  12. Some features of the bioelectric activity of the muscles with prolonged hypokinesia

    NASA Technical Reports Server (NTRS)

    Belaya, N. A.; Amirov, R. Z.; Shaposhnikov, Y. A.; Lebedeva, I. P.; Sologub, B. S.

    1978-01-01

    The effects of prolonged hypokinesia, brought on by confinement to bed and the attendant lack of motor activity, on the bioelectric activity of muscles are studied. Electromyographic measurements of amplitude and frequency indicators of muscular bioelectric activity were analyzed.

  13. Building Model NASA Satellites: Elementary Students Studying Science Using a NASA-Themed Transmedia Book Featuring Digital Fabrication Activities

    ERIC Educational Resources Information Center

    Tillman, Daniel; An, Song; Boren, Rachel; Slykhuis, David

    2014-01-01

    This study assessed the impact of nine lessons incorporating a NASA-themed transmedia book featuring digital fabrication activities on 5th-grade students (n = 29) recognized as advanced in mathematics based on their academic record. Data collected included a pretest and posttest of science content questions taken from released Virginia Standards…

  14. A triaxial accelerometer-based physical-activity recognition via augmented-signal features and a hierarchical recognizer.

    PubMed

    Khan, Adil Mehmood; Lee, Young-Koo; Lee, Sungyoung Y; Kim, Tae-Seong

    2010-09-01

    Physical-activity recognition via wearable sensors can provide valuable information regarding an individual's degree of functional ability and lifestyle. In this paper, we present an accelerometer sensor-based approach for human-activity recognition. Our proposed recognition method uses a hierarchical scheme. At the lower level, the state to which an activity belongs, i.e., static, transition, or dynamic, is recognized by means of statistical signal features and artificial-neural nets (ANNs). The upper level recognition uses the autoregressive (AR) modeling of the acceleration signals, thus, incorporating the derived AR-coefficients along with the signal-magnitude area and tilt angle to form an augmented-feature vector. The resulting feature vector is further processed by the linear-discriminant analysis and ANNs to recognize a particular human activity. Our proposed activity-recognition method recognizes three states and 15 activities with an average accuracy of 97.9% using only a single triaxial accelerometer attached to the subject's chest.

  15. Page turning solutions for musicians: a survey.

    PubMed

    Wolberg, George; Schipper, Irene

    2012-01-01

    Musicians have long been hampered by the challenge in turning sheet music while their hands are occupied playing an instrument. The sight of a human page turner assisting a pianist during a performance, for instance, is not uncommon. This need for a page turning solution is no less acute during practice sessions, which account for the vast majority of playing time. Despite widespread appreciation of the problem, there have been virtually no robust and affordable products to assist the musician. Recent progress in assistive technology and electronic reading devices offers promising solutions to this long-standing problem. The objective of this paper is to survey the technology landscape and assess the benefits and drawbacks of page turning solutions for musicians. A full range of mechanical and digital page turning products are reviewed. PMID:22246302

  16. AGU acts on NSF Page Charge Policy

    NASA Astrophysics Data System (ADS)

    Fast action by Headquarters alerted AGU members to a proposed change to the National Science Foundation's page charge policy that would weaken the ability of scientific societies to serve the scientific community.If adopted, NSF's new policy, announced in the Federal Register December 18, would remove the prohibition against allowing page charges to commercially produced journals. The proposal for the change was supposedly put forth to obtain a reaction from the scientific community.

  17. Description Meta Tags in Public Home and Linked Pages.

    ERIC Educational Resources Information Center

    Craven, Timothy C.

    2001-01-01

    Random samples of 1,872 Web pages registered with Yahoo! And 1,638 pages reachable from Yahoo!-registered pages were analyzed for use of meta tags and specifically those containing descriptions. Results: 727 (38.8%) of the Yahoo!-registered pages and 442 (27%) of the other pages included descriptions in meta tages. Some descriptions greatly…

  18. 47 CFR 22.503 - Paging geographic area authorizations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 2 2012-10-01 2012-10-01 false Paging geographic area authorizations. 22.503... PUBLIC MOBILE SERVICES Paging and Radiotelephone Service § 22.503 Paging geographic area authorizations. The FCC considers applications for and issues paging geographic area authorizations in the Paging...

  19. 47 CFR 22.503 - Paging geographic area authorizations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 2 2013-10-01 2013-10-01 false Paging geographic area authorizations. 22.503... PUBLIC MOBILE SERVICES Paging and Radiotelephone Service § 22.503 Paging geographic area authorizations. The FCC considers applications for and issues paging geographic area authorizations in the Paging...

  20. 47 CFR 22.503 - Paging geographic area authorizations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 2 2011-10-01 2011-10-01 false Paging geographic area authorizations. 22.503... PUBLIC MOBILE SERVICES Paging and Radiotelephone Service § 22.503 Paging geographic area authorizations. The FCC considers applications for and issues paging geographic area authorizations in the Paging...

  1. A Web Page Summarization for Mobile Phones

    NASA Astrophysics Data System (ADS)

    Hasegawa, Takaaki; Nishikawa, Hitoshi; Imamura, Kenji; Kikui, Gen'ichiro; Okumur, Manabu

    Recently, web pages for mobile devices are widely spread on the Internet and a lot of people can access web pages through search engines by mobile devices as well as personal computers. A summary of a retrieved web page is important because the people judge whether or not the page would be relevant to their information need according to the summary. In particular, the summary must be not only compact but also grammatical and meaningful when the users retrieve information using a mobile phone with a small screen. Most search engines seem to produce a snippet based on the keyword-in-context (KWIC) method. However, this simple method could not generate a refined summary suitable for mobile phones because of low grammaticality and content overlap with the page title. We propose a more suitable method to generate a snippet for mobile devices using sentence extraction and sentence compression methods. First, sentences are biased based on whether they include the query terms from the users or words that are relevant to the queries, as well as whether they do not overlap with the page title based on maximal marginal relevance (MMR). Second, the selected sentences are compressed based on their phrase coverage, which is measured by the scores of words, and their phrase connection probability measured based on the language model, according to the dependency structure converted from the sentence. The experimental results reveal the proposed method outperformed the KWIC method in terms of relevance judgment, grammaticality, non-redundancy and content coverage.

  2. Activity Participation and Sensory Features among Children with Autism Spectrum Disorders

    ERIC Educational Resources Information Center

    Little, Lauren M.; Ausderau, Karla; Sideris, John; Baranek, Grace T.

    2015-01-01

    Sensory features are highly prevalent among children with autism spectrum disorders (ASD) and have been shown to cluster into four patterns of response, including hyperresponsiveness, hyporesponsiveness, enhanced perception, and sensory interests, repetitions and seeking behaviors. Given the lack of large-scale research on the differential effects…

  3. Interfacial Reaction-Driven Formation of Silica Carbonate Biomorphs with Subcellular Topographical Features and Their Biological Activity.

    PubMed

    Wang, Guocheng; Zhao, Xiaobing; Möller, Marco; Moya, Sergio E

    2015-10-28

    We report the interfacial reaction-driven formation of micro/nanostructured strontium carbonate (SrCO3) biomorphs with subcellular topographical features on strontium zinc silicate (Sr2ZnSi2O7) biomedical coatings and explore their potential use in bone tissue engineering. The resulting SrCO3 crystals build a well-integrated scaffold surface that not only prevents burst release of ions from the coating but also presents nanotopographical features similar to cellular filopodia. The surface with biomorphic crystals enhances osteoblast adhesion, upregulates the alkaline phosphatase activity, and increases collagen production, highlighting the potential of the silica carbonate biomorphs for tissue regeneration. PMID:26455427

  4. Interfacial Reaction-Driven Formation of Silica Carbonate Biomorphs with Subcellular Topographical Features and Their Biological Activity.

    PubMed

    Wang, Guocheng; Zhao, Xiaobing; Möller, Marco; Moya, Sergio E

    2015-10-28

    We report the interfacial reaction-driven formation of micro/nanostructured strontium carbonate (SrCO3) biomorphs with subcellular topographical features on strontium zinc silicate (Sr2ZnSi2O7) biomedical coatings and explore their potential use in bone tissue engineering. The resulting SrCO3 crystals build a well-integrated scaffold surface that not only prevents burst release of ions from the coating but also presents nanotopographical features similar to cellular filopodia. The surface with biomorphic crystals enhances osteoblast adhesion, upregulates the alkaline phosphatase activity, and increases collagen production, highlighting the potential of the silica carbonate biomorphs for tissue regeneration.

  5. Towards global age-friendly cities: determining urban features that promote active aging.

    PubMed

    Plouffe, Louise; Kalache, Alexandre

    2010-09-01

    At the same time as cities are growing, their share of older residents is increasing. To engage and assist cities to become more "age-friendly," the World Health Organization (WHO) prepared the Global Age-Friendly Cities Guide and a companion "Checklist of Essential Features of Age-Friendly Cities". In collaboration with partners in 35 cities from developed and developing countries, WHO determined the features of age-friendly cities in eight domains of urban life: outdoor spaces and buildings; transportation; housing; social participation; respect and social inclusion; civic participation and employment; communication and information; and community support and health services. In 33 cities, partners conducted 158 focus groups with persons aged 60 years and older from lower- and middle-income areas of a locally defined geographic area (n = 1,485). Additional focus groups were held in most sites with caregivers of older persons (n = 250 caregivers) and with service providers from the public, voluntary, and commercial sectors (n = 515). No systematic differences in focus group themes were noted between cities in developed and developing countries, although the positive, age-friendly features were more numerous in cities in developed countries. Physical accessibility, service proximity, security, affordability, and inclusiveness were important characteristics everywhere. Based on the recurring issues, a set of core features of an age-friendly city was identified. The Global Age-Friendly Cities Guide and companion "Checklist of Essential Features of Age-Friendly Cities" released by WHO serve as reference for other communities to assess their age readiness and plan change.

  6. [Specific features of fear conditioning expression in active and passive rabbits].

    PubMed

    2013-11-01

    The active and passive rabbits selected previously on the basis of their behavior in open field and light-dark test, were subjected to fear conditioning using pairing light (4 s) with footshocks (10 Hz, 0.5 s). Heart rate and respiration rate were measured during the classical fear conditioning. Heart rate and respiration rate decreased in response to light before footshock in case of passive-defensive reaction. There were no heart rate and respiration rate reduction in the course of the active defensive reaction. In active rabbits, as compared to passive ones, the frequency of active locomotors reactions and heart rate were higher, the decrease of respiration rate to light was observed at later stages of training, and the detected bradycardia was not stable. Thus, based upon vegetative characteristics, the active rabbits had lower level of fear than passive ones. The active or passive behavioral strategies of animals were preserved during fear conditioning.

  7. Can simple interactions capture complex features of neural activity underlying behavior in a virtual reality environment?

    NASA Astrophysics Data System (ADS)

    Meshulam, Leenoy; Gauthier, Jeffrey; Brody, Carlos; Tank, David; Bialek, William

    The complex neural interactions which are abundant in most recordings of neural activity are relatively poorly understood. A prime example of such interactions can be found in the in vivo neural activity which underlies complex behaviors of mice, imaged in brain regions such as hippocampus and parietal cortex. Experimental techniques now allow us to accurately follow these neural interactions in the simultaneous activity of large neuronal populations of awake behaving animals. Here, we demonstrate that pairwise maximum entropy models can predict a surprising number of properties of the neural activity. The models, that are constrained with activity rates and interactions between pairs of neurons, are well fit to the activity `states' in the hippocampus and cortex of mice performing cognitive tasks while navigating in a virtual reality environment.

  8. The Luminous Polycyclic Aromatic Hydrocarbon Emission Features: Applications to High Redshift Galaxies and Active Galactic Nuclei

    NASA Astrophysics Data System (ADS)

    Shipley, Heath V.

    2016-01-01

    For decades, significant work has been applied to calibrating emission from the ultra-violet, nebular emission lines, far-infrared, X-ray and radio as tracers of the star-formation rate (SFR) in distant galaxies. Understanding the exact rate of star-formation and how it evolves with time and galaxy mass has deep implications for how galaxies form. The co-evolution of star-formation and supermassive black hole (SMBH) accretion is one of the key problems in galaxy formation theory. But, many of these SFR indicators are influenced by SMBH accretion in galaxies and result in unreliable SFRs. Utilizing the luminous polycyclic aromatic hydrocarbon (PAH) emission features, I provide a new robust SFR calibration using the luminosity emitted from the PAHs at 6.2μm, 7.7μm and 11.3μm to solve this. The PAH features emit strongly in the mid-infrared (mid-IR; 5-25μm) mitigating dust extinction, containing on average 5-10% of the total IR luminosity in galaxies. I use a sample of 105 star-forming galaxies covering a range of total IR luminosity, LIR = L(8-1000μm) = 109 - 1012 L⊙ and redshift 0 < z < 0.4, with mid-IR spectroscopy from the Spitzer Infrared Spectrograph (IRS), and data covering other SFR indicators (Hα emission and rest-frame 24μm continuum emission). The PAH luminosity correlates linearly with the SFR as measured by the Hα luminosity (corrected for attenuation using the mono-chromatic rest-frame 24μm emission), with a tight scatter of <0.15 dex. The scatter is comparable to that between SFRs derived from the Paα and dust-corrected Hα emission lines. We present a case study in advance of JWST, which will be capable of measuring SFRs (from 8μm rest-frame photometry, i.e. PAHs) in distant galaxies (z ≤ 2) with JWST/MIRI to SFRs as low as ~10 M⊙yr-1, because the PAH features are so bright. We use Spitzer/IRS observations of PAH features in lensed star-forming galaxies at 1 < z < 3 to demonstrate the utility of the PAHs to derive SFRs that agree with

  9. Benzenediol lactones: a class of fungal metabolites with diverse structural features and biological activities.

    PubMed

    Shen, Weiyun; Mao, Hongqiang; Huang, Qian; Dong, Jinyan

    2015-06-01

    Benzenediol lactones are a structurally variable family of fungal polyketide metabolites possessing a macrolide core structure fused into a resorcinol aromatic ring. These compounds are widespread in fungi mainly in the genera such as Aigialus, Cochliobolus, Curvularia, Fusarium, Humicola, Lasiodiplodia, Penicillium and Pochonia etc. Most of these fungal metabolites were reported to possess several interesting biological activities, such as cytotoxicities, nematicidal properties, inhibition of various kinases, receptor agonists, anti-inflammatory activities, heat shock response and immune system modulatory activities etc. This review summarizes the research on the isolation, structure elucidation, and biological activities of the benzenediol lactones, along with some available structure-activity relationships, biosynthetic studies, first syntheses, and syntheses that lead to the revision of structure or stereochemistry, published up to the year of 2014. More than 190 benzenediol lactones are described, and over 300 references cited. PMID:25559850

  10. Features of the Built Environment Related to Physical Activity Friendliness and Children’s Obesity and Other Risk Factors

    PubMed Central

    Taylor, Wendell C.; Upchurch, Sandra L.; Brosnan, Christine A.; Selwyn, Beatrice J.; Nguyen, Thong Q.; Villagomez, Evangelina Trejo; Meininger, Janet C.

    2014-01-01

    Objectives We investigated the relationships among environmental features of physical activity friendliness, socioeconomic indicators, and prevalence of obesity (BMI status), central adiposity (waist circumference, waist-height ratio), and hypertension. Design The design was cross-sectional; the study was correlational. Sample The sample was 911 kindergarteners through sixth graders from three schools in an urban school district residing in 13 designated neighborhoods. Measurements Data from walking environmental community audits, census data for socioeconomic indicators, body mass index, waist circumference, waist-height ratio, and blood pressure were analyzed. A modified Alfonzo’s Hierarchy of Walking Needs model was the conceptual framework for environmental features (i.e., accessibility, safety, comfort, and pleasurability) related to physical activity. Results Accessibility was significantly and negatively correlated with prevalence of obesity and with prevalence of a waist-height ratio > 0.50. When neighborhood education was controlled, and when both neighborhood education and poverty were controlled with partial correlational analysis, comfort features of a walking environment were significantly and positively related to prevalence of obesity. When poverty was controlled with partial correlation, accessibility was significantly and negatively correlated with prevalence of waist-height ratio > 0.50. Conclusions The built environment merits further research to promote physical activity and stem the obesity epidemic in children. Our approach can be a useful framework for future research. PMID:25112374

  11. Magnetic Tilts in Sunspot Groups and Active regions in the Cycle 23 obtained from the Solar Feature Catalogues

    NASA Astrophysics Data System (ADS)

    Zharkov, S. I.; Zharkova, V. V.; Bianda, M.; Cartesi, S.

    We compare a few methods for calculation of magnetic tilts in active regions using using the automated sunspot group classification from the Solar Feature Catalogues http solar inf brad ac uk for 1996-2005 The best performing methods were applied to investigate the statistical variations of magnetic field tilt in sunspot groups and their relation to the total magnetic field contained in sunspots during different phases of the solar cycle 23 The classification results are compared with the similar research for the cycle 22 and the specifics on the cycle 23 is discussed The results are also tested against the existing solar dynamo models and their applicability for the solar activity forecast

  12. Phenomenological features of mortality and morbidity dynamics in Tomsk versus heliogeophysical activity

    NASA Astrophysics Data System (ADS)

    Borodin, A. S.; Tuzhilkin, D. A.; Gudina, M. V.; Vladimirsky, B. M.

    2015-12-01

    The influence of heliogeophysical activity on the morbidity and mortality of the population in Tomsk is studied epidemiologically on the basis of regional data. The biological effectiveness of heliogeophysical factors selected on the basis of the Karhunen-Loeve method from epidemiological data on the morbidity and mortality in Tomsk in 1990-2008 is estimated. An analysis of the impact of variations in heliogeophysical activity on morbidity and mortality (according to the International Statistical Classification of Diseases and Related Health, ICD-10) showed the existence of common factors within different nosological classes that reliably correlate with the major components of variations in characteristic indices of heliogeophysical activity.

  13. The mediating role of facebook fan pages.

    PubMed

    Chih, Wen-Hai; Hsu, Li-Chun; Wang, Kai-Yu; Lin, Kuan-Yu

    2014-01-01

    Using the dual mediation hypothesis, this study investigates the role of interestingness (the power of attracting or holding one's attention) attitude towards the news, in the formation of Facebook Fan Page users' electronic word-of-mouth intentions. A total of 599 Facebook fan page users in Taiwan were recruited and structural equation modeling (SEM) was used to test the research hypotheses. The results show that both perceived news entertainment and informativeness positively influence interestingness attitude towards the news. Interestingness attitude towards the news subsequently influences hedonism and utilitarianism attitudes towards the Fan Page, which then influence eWOM intentions. Interestingness attitude towards the news plays a more important role than hedonism and utilitarianism attitudes in generating electronic word-of-mouth intentions. Based on the findings, the implications and future research suggestions are provided. PMID:24875695

  14. European user trial of paging by satellite

    NASA Technical Reports Server (NTRS)

    Fudge, R. E.; Fenton, C. J.

    1990-01-01

    British Telecom conceived the idea of adapting their existing paging service, together with the use of existing terrestrial pagers, to yield a one way data (i.e., paging) satellite service to mobiles. The user trial of paging by satellites was successful. It demonstrated that services could be provided over a wide geographical area to low priced terminals. Many lessons were learned in unexpected areas. These include the need for extensive liaison with all users involved, especially the drivers, to ensure they understood the potential benefits. There was a significant desire for a return acknowledgement channel or even a return data channel. Above all there is a need to ensure that the equipment can be taken across European borders and legitimately used in all European countries. The next step in a marketing assessment would be to consider the impact of two way data messaging such as INMARSAT-C.

  15. A rendering approach for stereoscopic web pages

    NASA Astrophysics Data System (ADS)

    Zhang, Jianlong; Wang, Wenmin; Wang, Ronggang; Chen, Qinshui

    2014-03-01

    Web technology provides a relatively easy way to generate contents for us to recognize the world, and with the development of stereoscopic display technology, the stereoscopic devices will become much more popular. The combination of web technology and stereoscopic display technology will bring revolutionary visual effect. The Stereoscopic 3D (S3D) web pages, in which text, image and video may have different depth, can be displayed on stereoscopic display devices. This paper presents the approach about how to render two viewing S3D web pages including text, images, widgets: first, an algorithm should be developed in order to display stereoscopic elements like text, widgets by using 2D graphic library; second, a method should be presented to render stereoscopic web page based on current framework of the browser; third, a rough solution is invented to fix the problem that comes out in the method.

  16. An Analysis of Activities in Saudi Arabian Middle School Science Textbooks and Workbooks for the Inclusion of Essential Features of Inquiry

    NASA Astrophysics Data System (ADS)

    Aldahmash, Abdulwali H.; Mansour, Nasser S.; Alshamrani, Saeed M.; Almohi, Saeed

    2016-01-01

    This study examines Saudi Arabian middle school science textbooks' coverage of the essential features of scientific inquiry. All activities in the middle school science textbooks and workbooks were analyzed by using the scientific inquiry `essential features' rubric. The results indicated that the essential features are included in about 59 % of the analyzed science activities. However, feature 2, `making learner give priority to evidence in responding to questions' and feature 3, `allowing learner to formulate explanations from evidence' appeared more frequently than the other three features (feature 1: engaging learner in scientifically oriented questions, feature 4: helping learner connect explanations to scientific knowledge, and feature 5: helping learner communicate and justify explanations to others), whether in the activities as a whole, or in the activities included in each of the four science domains (physical science, Earth science, life science and chemistry). These features are represented in almost all activities. This means that almost all activities in the middle school science textbooks and the workbooks include features 2 and 3. Meanwhile, the mean level of inclusion of the five essential features of scientific inquiry found in the middle school science textbooks and workbooks as a whole is 2.55. However, results found for features 1, 4, 5 and for in-level inclusion of the inquiry features in each of the science domains indicate that the inclusion of the essential inquiry features is teacher-centred. As a result, neither science textbooks nor workbooks provide students with the opportunity or encouragement to develop their inquiry skills. Consequently, the results suggest important directions for educational administrators and policy-makers in the preparation and use of science educational content.

  17. An Analysis of Activities in Saudi Arabian Middle School Science Textbooks and Workbooks for the Inclusion of Essential Features of Inquiry

    ERIC Educational Resources Information Center

    Aldahmash, Abdulwali H.; Mansour, Nasser S.; Alshamrani, Saeed M.; Almohi, Saeed

    2016-01-01

    This study examines Saudi Arabian middle school science textbooks' coverage of the essential features of scientific inquiry. All activities in the middle school science textbooks and workbooks were analyzed by using the scientific inquiry "essential features" rubric. The results indicated that the essential features are included in about…

  18. 60 FR 39766 - Supplement to Renovate the Alcohol Detention Center, Page, Arizona

    Federal Register 2010, 2011, 2012, 2013, 2014

    1995-08-03

    ... and alcohol treatment activities. The facility is currently being used to serve individuals targeted... treatment and counseling interventions. Alcohol related deaths, accidents, injuries, illness, violence, and... HUMAN SERVICES Supplement to Renovate the Alcohol Detention Center, Page, Arizona AGENCY: Center...

  19. [The behaviour and respiration features in rabbits with different pattern of their open field locomotor activity].

    PubMed

    Pavlova, I V; Levshina, I P; Venetsian, G L; Shuĭkin, N N; Ziablitseva, E A

    2005-09-01

    Behavior of 19 Chinchilla rabbits was tested in the open field. By the results of the first trial, animals were divided into three groups by the type of the exploratory locomotor activity (passive--37%; active--21; and medium--42%). During the repeated open field trials, the passive rabbits increased their activity and the active ones decreased it. Correlations were found between the open field behavior and patterns of the external respiration in the absence of movements. The longest respiratory cycles, expirations and respiratory breath holdings were observed in passive rabbits. Animals with prevailing right turnings in the open field displayed longer respiratory cycles and expirations than those with prevailing left turnings. It seems that the pattern of external respiration can predict the passive defensive strategy of rabbits in negative emotional situations.

  20. Playability: Built and Social Environment Features That Promote Physical Activity Within Children.

    PubMed

    Timperio, Anna; Reid, Jacqueline; Veitch, Jenny

    2015-12-01

    The role of neighbourhood built and social environments in shaping children's physical activity has received increasing interest over the past 10 years. We reviewed recent evidence published between 2011 and 2014. Most of the recent evidence continues to be cross-sectional. Few macro-level neighbourhood attributes were consistently associated with physical activity in the expected direction. The strongest evidence for associations between neighbourhood attributes and physical activity with was for the transportation environment, particularly in relation to proximity to school and transport-related physical activity. There was intermediate evidence that neighbourhood walking/cycling infrastructure and pedestrian safety structures are associated with transport-related PA. Recent evidence on associations between the neighbourhood built and social environment and children's PA is modest. Stronger study designs and greater attention to conceptual-matching and specificity of measures are critical to advance the evidence base.

  1. Page Recognition: Quantum Leap In Recognition Technology

    NASA Astrophysics Data System (ADS)

    Miller, Larry

    1989-07-01

    No milestone has proven as elusive as the always-approaching "year of the LAN," but the "year of the scanner" might claim the silver medal. Desktop scanners have been around almost as long as personal computers. And everyone thinks they are used for obvious desktop-publishing and business tasks like scanning business documents, magazine articles and other pages, and translating those words into files your computer understands. But, until now, the reality fell far short of the promise. Because it's true that scanners deliver an accurate image of the page to your computer, but the software to recognize this text has been woefully disappointing. Old optical-character recognition (OCR) software recognized such a limited range of pages as to be virtually useless to real users. (For example, one OCR vendor specified 12-point Courier font from an IBM Selectric typewriter: the same font in 10-point, or from a Diablo printer, was unrecognizable!) Computer dealers have told me the chasm between OCR expectations and reality is so broad and deep that nine out of ten prospects leave their stores in disgust when they learn the limitations. And this is a very important, very unfortunate gap. Because the promise of recognition -- what people want it to do -- carries with it tremendous improvements in our productivity and ability to get tons of written documents into our computers where we can do real work with it. The good news is that a revolutionary new development effort has led to the new technology of "page recognition," which actually does deliver the promise we've always wanted from OCR. I'm sure every reader appreciates the breakthrough represented by the laser printer and page-makeup software, a combination so powerful it created new reasons for buying a computer. A similar breakthrough is happening right now in page recognition: the Macintosh (and, I must admit, other personal computers) equipped with a moderately priced scanner and OmniPage software (from Caere

  2. Object features, object locations, and object files: which does selective attention activate and when?

    PubMed

    Lamy, D; Tsal, Y

    2000-08-01

    The representation within which attention operates was investigated in 3 experiments. The task was similar to that of R. Egly, J. Driver, and R. D. Rafal (1994). Participants had to detect the presence of a target at 1 of 4 ends of 2 shapes, differing in color and form. A precue appeared at 1 of the 4 possible corners. The 2 shapes occupied either the same or different locations in the cuing and target displays. The results showed that the cued object location was attended whether or not space was task relevant, whereas the cued object features (color and form) were attended only when these were task relevant. Moreover, when object file continuity was maintained through continuous movement, attention was found to follow the cued object file as it moved while also accruing to the cued location.

  3. [Importance of the hyperuricaemia, gout and gender nosological features in the activity of general practitioner - family doctor].

    PubMed

    Rudichenko, V M

    2012-01-01

    In this article there were analyzed gender data about features of hyperuricaemia and gout: women are much older at the onset of gout arthritis (one of main reasons, probably, makes menopause by itself), have more associated comorbid deseases as hypertension and kidney failure and drinks less alcoholic beverages. It was noticed, that typical localisation of the lesion on the first toe is less often in women, and women are more inclined to use diuretics among medical drugs. Abovementioned clinical features are of some importance for the broad activity of general practitioners - family doctors. Gender features of polyarthicular gout are not uniformed. Scientific researches confirmed possibility of the genetic basis of the uric acid metabolism, which influences some fenotypical features of the organism. Several genes are known for their influence on serum uric acid: PDZK1, GCKR, SLC2A9, ABCG2, LRRC16A, SLC17A3, SLC16A9 and SLC22A12. However, conclusions of the research works confirm the necessity of scientific clarification of the importance of different factors of gender differences.

  4. Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genes

    PubMed Central

    Kato, Lucia; Begum, Nasim A.; Burroughs, A. Maxwell; Doi, Tomomitsu; Kawai, Jun; Daub, Carsten O.; Kawaguchi, Takahisa; Matsuda, Fumihiko; Hayashizaki, Yoshihide; Honjo, Tasuku

    2012-01-01

    Activation-induced cytidine deaminase (AID) is required for both somatic hypermutation and class-switch recombination in activated B cells. AID is also known to target nonimmunoglobulin genes and introduce mutations or chromosomal translocations, eventually causing tumors. To identify as-yet-unknown AID targets, we screened early AID-induced DNA breaks by using two independent genome-wide approaches. Along with known AID targets, this screen identified a set of unique genes (SNHG3, MALAT1, BCL7A, and CUX1) and confirmed that these loci accumulated mutations as frequently as Ig locus after AID activation. Moreover, these genes share three important characteristics with the Ig gene: translocations in tumors, repetitive sequences, and the epigenetic modification of chromatin by H3K4 trimethylation in the vicinity of cleavage sites. PMID:22308462

  5. Ordinary and Activated Bone Grafts: Applied Classification and the Main Features

    PubMed Central

    Deev, R. V.; Drobyshev, A. Y.; Bozo, I. Y.; Isaev, A. A.

    2015-01-01

    Bone grafts are medical devices that are in high demand in clinical practice for substitution of bone defects and recovery of atrophic bone regions. Based on the analysis of the modern groups of bone grafts, the particularities of their composition, the mechanisms of their biological effects, and their therapeutic indications, applicable classification was proposed that separates the bone substitutes into “ordinary” and “activated.” The main differential criterion is the presence of biologically active components in the material that are standardized by qualitative and quantitative parameters: growth factors, cells, or gene constructions encoding growth factors. The pronounced osteoinductive and (or) osteogenic properties of activated osteoplastic materials allow drawing upon their efficacy in the substitution of large bone defects. PMID:26649300

  6. Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genes.

    PubMed

    Kato, Lucia; Begum, Nasim A; Burroughs, A Maxwell; Doi, Tomomitsu; Kawai, Jun; Daub, Carsten O; Kawaguchi, Takahisa; Matsuda, Fumihiko; Hayashizaki, Yoshihide; Honjo, Tasuku

    2012-02-14

    Activation-induced cytidine deaminase (AID) is required for both somatic hypermutation and class-switch recombination in activated B cells. AID is also known to target nonimmunoglobulin genes and introduce mutations or chromosomal translocations, eventually causing tumors. To identify as-yet-unknown AID targets, we screened early AID-induced DNA breaks by using two independent genome-wide approaches. Along with known AID targets, this screen identified a set of unique genes (SNHG3, MALAT1, BCL7A, and CUX1) and confirmed that these loci accumulated mutations as frequently as Ig locus after AID activation. Moreover, these genes share three important characteristics with the Ig gene: translocations in tumors, repetitive sequences, and the epigenetic modification of chromatin by H3K4 trimethylation in the vicinity of cleavage sites.

  7. Utilization of the Google Maps API in WebPages

    NASA Astrophysics Data System (ADS)

    Ricket, D.

    2006-12-01

    Google Maps, which offers a powerful, user-friendly mapping technology including business locations, contact information, and driving directions, also provides an easy-to-use platform for representing scientific information in a geographic format. Users can add draggable maps, satellite imagery, and zoom functionality technology to their own web pages using the Google Maps API. Features such as overlays (including markers and polylines) can be customized to show geologic map features and display shadowed "info windows" can be customized with additional information, images along with the direction they were taken, and access to data. A demonstration will be given of how to import large datasets into Google Maps, along formatting tips and tricks. Discussion of how the geoscience community would like to use both 2D and 3D mapping technologies is encouraged.

  8. Making rainfall features fun: scientific activities for teaching children aged 5-12 years

    NASA Astrophysics Data System (ADS)

    Gires, Auguste; Muller, Catherine L.; le Gueut, Marie-Agathe; Schertzer, Daniel

    2016-05-01

    Research projects now rely on an array of different channels to increase impact, including high-level scientific output, tools, and equipment, but also communication, outreach, and educational activities. This paper focuses on education for children aged 5-12 years and presents activities that aim to help them (and their teachers) grasp some of the complex underlying issues in environmental science. More generally, it helps children to become familiarized with science and scientists, with the aim to enhance scientific culture and promote careers in this field. The activities developed are focused on rainfall: (a) designing and using a disdrometer to observe the variety of drop sizes; (b) careful recording of successive dry and rainy days and reproducing patterns using a simple model based on fractal random multiplicative cascades; and (c) collaboratively writing a children's book about rainfall. These activities are discussed in the context of current state-of-the-art pedagogical practices and goals set by project funders, especially in a European Union framework.

  9. ActiveTutor: Towards More Adaptive Features in an E-Learning Framework

    ERIC Educational Resources Information Center

    Fournier, Jean-Pierre; Sansonnet, Jean-Paul

    2008-01-01

    Purpose: This paper aims to sketch the emerging notion of auto-adaptive software when applied to e-learning software. Design/methodology/approach: The study and the implementation of the auto-adaptive architecture are based on the operational framework "ActiveTutor" that is used for teaching the topic of computer science programming in first-grade…

  10. Galactan sulfate of Grateloupia indica: Isolation, structural features and antiviral activity.

    PubMed

    Chattopadhyay, Kausik; Mateu, Cecilia G; Mandal, Pinaki; Pujol, Carlos A; Damonte, Elsa B; Ray, Bimalendu

    2007-05-01

    Natural compounds offer interesting pharmacological perspectives for antiviral drug development with regard to broad-spectrum antiviral properties and novel modes of action. In this study, we have analyzed polysaccharide fractions isolated from Grateloupia indica. The crude water extract (GiWE) as well as one fraction (F3) obtained by anion exchange chromatography had potent anti-HSV activity. Their inhibitory concentration 50% (IC50) values (0.12-1.06 microg/ml) were much lower than cytotoxic concentration 50% values (>850 microg/ml). These fractions, which were effective antiviral inhibitors if added only during the adsorption period, had very low anticoagulant activity. Furthermore, they had no direct inactivating effect on virions in a virucidal assay. Chemical, chromatographic and spectroscopic methods showed that the active polysaccharide, which has an apparent molecular mass of 60 kDa and negative specific rotation [alpha]D(32) -16 degrees (c 0.2, H2O), contains alpha-(1-->4)- and alpha-(1-->3)-linked galactopyranose residues. Sulfate groups, if present, are located mostly at C-2/6 of (1-->4)- and C-4/6 of (1-->3)-linked galactopyranosyl units, and are essential for the anti herpetic activity of this polymer. PMID:17451760

  11. Structural features and antiviral activity of sulphated fucans from the brown seaweed Cystoseira indica.

    PubMed

    Mandal, Pinaki; Mateu, Cecilia Gabriela; Chattopadhyay, Kausik; Pujol, Carlos Alberto; Damonte, Elsa Beatriz; Ray, Bimalendu

    2007-01-01

    Natural compounds offer interesting pharmacological perspectives for antiviral drug development. In this study, we have analysed sulphated-fucan-containing fractions isolated from the brown seaweed Cystoseira indica. The crude water extract (CiWE) and the main fraction (CiF3) obtained by anion exchange chromatography had potent antiviral activity against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2) without cytotoxicity for Vero cell cultures. Furthermore, they had no direct inactivating effect on virions in a virucidal assay, and lacked anticoagulant activity. The mode of action of these compounds could be mainly ascribed to an inhibitory effect on virus adsorption. Chemical, chromatographic and spectroscopic methods showed that the major polysaccharide had an apparent molecular mass of 35 kDa and contained a backbone of alpha-(1 --> 3)-linked fucopyranosyl residues substituted at C-2 with fucopyranosyl and xylopyranosyl residues. This sulphated fucan, considered the active principle of the C. indica water extract, also contained variously linked xylose and galactose units and glucuronic acid residues. Sulphate groups, if present, are located mostly at C-4 of (1 --> 3)-linked fucopyranosyl units, and appeared to be very important for the anti-herpetic activity of this polymer. PMID:17626599

  12. Metabolic Features of Protochlamydia amoebophila Elementary Bodies – A Link between Activity and Infectivity in Chlamydiae

    PubMed Central

    Watzka, Margarete; Wultsch, Anna; Tziotis, Dimitrios; Montanaro, Jacqueline; Richter, Andreas; Schmitt-Kopplin, Philippe; Horn, Matthias

    2013-01-01

    The Chlamydiae are a highly successful group of obligate intracellular bacteria, whose members are remarkably diverse, ranging from major pathogens of humans and animals to symbionts of ubiquitous protozoa. While their infective developmental stage, the elementary body (EB), has long been accepted to be completely metabolically inert, it has recently been shown to sustain some activities, including uptake of amino acids and protein biosynthesis. In the current study, we performed an in-depth characterization of the metabolic capabilities of EBs of the amoeba symbiont Protochlamydia amoebophila. A combined metabolomics approach, including fluorescence microscopy-based assays, isotope-ratio mass spectrometry (IRMS), ion cyclotron resonance Fourier transform mass spectrometry (ICR/FT-MS), and ultra-performance liquid chromatography mass spectrometry (UPLC-MS) was conducted, with a particular focus on the central carbon metabolism. In addition, the effect of nutrient deprivation on chlamydial infectivity was analyzed. Our investigations revealed that host-free P. amoebophila EBs maintain respiratory activity and metabolize D-glucose, including substrate uptake as well as host-free synthesis of labeled metabolites and release of labeled CO2 from 13C-labeled D-glucose. The pentose phosphate pathway was identified as major route of D-glucose catabolism and host-independent activity of the tricarboxylic acid (TCA) cycle was observed. Our data strongly suggest anabolic reactions in P. amoebophila EBs and demonstrate that under the applied conditions D-glucose availability is essential to sustain metabolic activity. Replacement of this substrate by L-glucose, a non-metabolizable sugar, led to a rapid decline in the number of infectious particles. Likewise, infectivity of Chlamydia trachomatis, a major human pathogen, also declined more rapidly in the absence of nutrients. Collectively, these findings demonstrate that D-glucose is utilized by P. amoebophila EBs and provide

  13. Metabolic features of Protochlamydia amoebophila elementary bodies--a link between activity and infectivity in Chlamydiae.

    PubMed

    Sixt, Barbara S; Siegl, Alexander; Müller, Constanze; Watzka, Margarete; Wultsch, Anna; Tziotis, Dimitrios; Montanaro, Jacqueline; Richter, Andreas; Schmitt-Kopplin, Philippe; Horn, Matthias

    2013-01-01

    The Chlamydiae are a highly successful group of obligate intracellular bacteria, whose members are remarkably diverse, ranging from major pathogens of humans and animals to symbionts of ubiquitous protozoa. While their infective developmental stage, the elementary body (EB), has long been accepted to be completely metabolically inert, it has recently been shown to sustain some activities, including uptake of amino acids and protein biosynthesis. In the current study, we performed an in-depth characterization of the metabolic capabilities of EBs of the amoeba symbiont Protochlamydia amoebophila. A combined metabolomics approach, including fluorescence microscopy-based assays, isotope-ratio mass spectrometry (IRMS), ion cyclotron resonance Fourier transform mass spectrometry (ICR/FT-MS), and ultra-performance liquid chromatography mass spectrometry (UPLC-MS) was conducted, with a particular focus on the central carbon metabolism. In addition, the effect of nutrient deprivation on chlamydial infectivity was analyzed. Our investigations revealed that host-free P. amoebophila EBs maintain respiratory activity and metabolize D-glucose, including substrate uptake as well as host-free synthesis of labeled metabolites and release of labeled CO2 from (13)C-labeled D-glucose. The pentose phosphate pathway was identified as major route of D-glucose catabolism and host-independent activity of the tricarboxylic acid (TCA) cycle was observed. Our data strongly suggest anabolic reactions in P. amoebophila EBs and demonstrate that under the applied conditions D-glucose availability is essential to sustain metabolic activity. Replacement of this substrate by L-glucose, a non-metabolizable sugar, led to a rapid decline in the number of infectious particles. Likewise, infectivity of Chlamydia trachomatis, a major human pathogen, also declined more rapidly in the absence of nutrients. Collectively, these findings demonstrate that D-glucose is utilized by P. amoebophila EBs and provide

  14. Distinct features of circulating microparticles and their relationship with disease activity in inflammatory bowel disease

    PubMed Central

    Voudoukis, Evangelos; Vetsika, Eleni-Kyriaki; Giannakopoulou, Konstantina; Karmiris, Konstantinos; Theodoropoulou, Angeliki; Sfiridaki, Aekaterini; Georgoulias, Vassilis; Paspatis, Gregorios A.; Koutroubakis, Ioannis E.

    2016-01-01

    Background There is evidence that circulating microparticles (MPs) and annexin (+) platelet-derived MPs (PDMPs) are increased in inflammatory bowel disease (IBD). The aim of our study was to characterize the abundance, origin, and annexin V binding of MPs in patients with IBD and correlate them with the disease characteristics. Methods Case-control study of 46 IBD patients (23 Crohn’s disease, 23 ulcerative colitis) and 40 matched healthy controls (HC). MPs were divided according to annexin V binding, their origin was estimated based on specific cell membrane markers in plasma samples and their number was calculated via flow cytometry. Clinical and laboratory activity indices were also analyzed. Results Annexin (-) PDMPs (P=0.0004), total (P=0.04) and annexin (+) monocyte-derived MPs (P=0.02) were increased and annexin (-) total MPs (P=0.0007) were decreased in IBD patients compared to HC. The annexin (+)/(-) ratio of all MP types were significantly elevated in IBD patients compared to HC (P<0.003). IBD patients with active disease displayed elevated total and annexin (+) total MPs, total, annexin (+) and (-) PDMPs compared with those in remission (P<0.05). Annexin (-) PDMPs were considerably increased in IBD patients with active compared to those with inactive disease (P=0.0013). Total and annexin (-) PDMPs were significantly correlated with most of the disease activity indices (P<0.05). Conclusion The majority of circulating MPs, their counterparts and particularly annexin (-) PDMPs are increased in active IBD patients. Annexin (+)/(-) ratio proved to be the most reliable distinctive MP index between HC and IBD patients. PMID:27065731

  15. Enhancing magnetic nanoparticle-based DNA transfection: Intracellular-active cassette features

    NASA Astrophysics Data System (ADS)

    Vernon, Matthew Martin

    Efficient plasmid DNA transfection of embryonic stem cells, mesenchymal stem cells, neural cell lines and the majority of primary cell lines is a current challenge in gene therapy research. Magnetic nanoparticle-based DNA transfection is a gene vectoring technique that is promising because it is capable of outperforming most other non-viral transfection methods in terms of both transfection efficiency and cell viability. The nature of the DNA vector implemented depends on the target cell phenotype, where the particle surface chemistry and DNA binding/unbinding kinetics of the DNA carrier molecule play a critical role in the many steps required for successful gene transfection. Accordingly, Neuromag, an iron oxide/polymer nanoparticle optimized for transfection of neural phenotypes, outperforms many other nanoparticles and lipidbased DNA carriers. Up to now, improvements to nanomagnetic transfection techniques have focused mostly on particle functionalization and transfection parameter optimization (cell confluence, growth media, serum starvation, magnet oscillation parameters, etc.). None of these parameters are capable of assisting the nuclear translocation of delivered plasmid DNA once the particle-DNA complex is released from the endosome and dissociates in the cell's cytoplasm. In this study, incorporation of a DNA targeting sequence (DTS) feature in the transfecting plasmid DNA confers improved nuclear translocation, demonstrating significant improvement in nanomagnetic transfection efficiency in differentiated SH-SY5Y neuroblastoma cells. Other parameters, such as days in vitro, are also found to play a role and represent potential targets for further optimization.

  16. Accounting Programs' Home Pages: What's Happening.

    ERIC Educational Resources Information Center

    Peek, Lucia E.; Roxas, Maria L.

    2002-01-01

    Content analysis of 62 accounting programs' websites indicated the following: 53% include mission statements; 62.9% list accreditation; many faculty biographies and personal pages used inconsistent formats; provision of information on financial aid, student organizations, career services, and certified public accountant requirements varied. Many…

  17. 24 CFR 1710.105 - Cover page.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... DEVELOPMENT (INTERSTATE LAND SALES REGISTRATION PROGRAM) LAND REGISTRATION Reporting Requirements § 1710.105... 24 Housing and Urban Development 5 2012-04-01 2012-04-01 false Cover page. 1710.105 Section 1710.105 Housing and Urban Development Regulations Relating to Housing and Urban Development...

  18. Turning the Page with Preconference Workshops

    ERIC Educational Resources Information Center

    Knowledge Quest, 2011

    2011-01-01

    For those who are experiencing a lack of creative inspiration within their school library program but are ready to "turn a page" in their career or school library program, they may head to Minneapolis to attend one of the many great preconference workshops. This article presents and describes preconference workshops design to rid librarians of the…

  19. Adding Graphics to Your WWW Page.

    ERIC Educational Resources Information Center

    Descy, Don E.

    1995-01-01

    Explains how to retrieve graphics that are available on the World Wide Web and add them to a Web page using a word processor that can save documents in an ASCII (American Standard Code Information Interchange) text format and a new version of Netscape. A list of various, unrelated Internet resources is also included. (LRW)

  20. What's Not Funny about the Funny Pages?

    ERIC Educational Resources Information Center

    Lum, Lydia

    2008-01-01

    As a kid, Darrin Bell devoured newspaper comic strips. So it was disappointing whenever editors refused years later to add his comic strip, "Candorville," to their funny pages as soon as they saw that his lead characters were minorities. The editors would say they already carried a so-called Black strip. It is difficult for cartoonists like Bell…

  1. Accessibility of Special Education Program Home Pages.

    ERIC Educational Resources Information Center

    Flowers, Claudia P.; Bray, Marty; Algozzine, Robert F.

    1999-01-01

    Eighty-nine special education Web sites were evaluated for accessibility errors. Most (73 percent) special education home pages had accessibility problems, and the majority of these errors severely limited access for individuals with disabilities. The majority of the errors can be easily corrected. Recommendations and methods for improving…

  2. Thomas Jefferson, Page Design, and Desktop Publishing.

    ERIC Educational Resources Information Center

    Hartley, James

    1991-01-01

    Discussion of page design for desktop publishing focuses on the importance of functional issues as opposed to aesthetic issues, and criticizes a previous article that stressed aesthetic issues. Topics discussed include balance, consistency in text structure, and how differences in layout affect the clarity of "The Declaration of Independence."…

  3. Efficient Web Change Monitoring with Page Digest

    SciTech Connect

    Buttler, D J; Rocco, D; Liu, L

    2004-02-20

    The Internet and the World Wide Web have enabled a publishing explosion of useful online information, which has produced the unfortunate side effect of information overload: it is increasingly difficult for individuals to keep abreast of fresh information. In this paper we describe an approach for building a system for efficiently monitoring changes to Web documents. This paper has three main contributions. First, we present a coherent framework that captures different characteristics of Web documents. The system uses the Page Digest encoding to provide a comprehensive monitoring system for content, structure, and other interesting properties of Web documents. Second, the Page Digest encoding enables improved performance for individual page monitors through mechanisms such as short-circuit evaluation, linear time algorithms for document and structure similarity, and data size reduction. Finally, we develop a collection of sentinel grouping techniques based on the Page Digest encoding to reduce redundant processing in large-scale monitoring systems by grouping similar monitoring requests together. We examine how effective these techniques are over a wide range of parameters and have seen an order of magnitude speed up over existing Web-based information monitoring systems.

  4. Reconfigurable Full-Page Braille Displays

    NASA Technical Reports Server (NTRS)

    Garner, H. Douglas

    1994-01-01

    Electrically actuated braille display cells of proposed type arrayed together to form full-page braille displays. Like other braille display cells, these provide changeable patterns of bumps driven by digitally recorded text stored on magnetic tapes or in solid-state electronic memories. Proposed cells contain electrorheological fluid. Viscosity of such fluid increases in strong electrostatic field.

  5. 47 CFR 22.531 - Channels for paging operation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 22.531 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES PUBLIC MOBILE SERVICES Paging and Radiotelephone Service Paging Operation § 22.531 Channels for paging operation. The following channels are allocated for assignment to base transmitters that provide paging...

  6. The Luminous Polycyclic Aromatic Hydrocarbon Emission Features: Applications to High Redshift Galaxies and Active Galactic Nuclei

    NASA Astrophysics Data System (ADS)

    Shipley, Heath; Papovich, Casey

    2015-08-01

    We provide a new robust star-formation rate (SFR) calibration using the luminosity from polycyclic aromatic hydrogen (PAH) molecules. The PAH features emit strongly in the mid-infrared (mid-IR; 3-19μm), mitigating dust extinction, and they are very luminous, containing 5-10% of the total IR luminosity in galaxies. We derive the calibration of the PAH luminosity as a SFR indicator using a sample of 105 star-forming galaxies covering a range of total IR luminosity, LIR = L(8-1000μm) = 109 - 1012 L⊙ and redshift 0 < z < 0.6. The PAH luminosity correlates linearly with the SFR as measured by the dust-corrected Hα luminosity (using the sum of the Hα and rest-frame 24μm luminosity from Kennicutt et al. 2009), with tight scatter of ~0.15 dex, comparable to the scatter in the dust-corrected Hα SFRs and Paα SFRs. We show this relation is sensitive to galaxy metallicity, where the PAH luminosity of galaxies with Z < 0.7 Z⊙ departs from the linear SFR relationship but in a behaved manor. We derive for this a correction to galaxies below solar metallicity. As a case study for observations with JWST, we apply the PAH SFR calibration to a sample of lensed galaxies at 1 < z < 3 with Spitzer Infrared Spectrograph (IRS) data, and we demonstrate the utility of PAHs to derive SFRs as accurate as those available from any other indicator. This new SFR indicator will be useful for probing the peak of the SFR density of the universe (1 < z < 3) and for studying the coevolution of star-formation and supermassive blackhole accretion contemporaneously in a galaxy.

  7. Classic to Contemporary: Famous Artists and Activities. A Teacher's Guide Featuring 19 Famous Artists' Biographies and Enrichment/Research Activities.

    ERIC Educational Resources Information Center

    Kinghorn, Harriet; Lewis-Spicer, Lisa

    By studying the lives, important achievements, and works of famous artists, students may come to understand what those artists hoped to communicate to the world. By participating in art activities that are related to these artists' styles, students practice skills of observing, analyzing, and creating. This instructional guide provides…

  8. Let's Meet Famous Artists. A Creative Art Activity Book. A Teacher's Guide Featuring 19 Famous Artists and Art Activities.

    ERIC Educational Resources Information Center

    Kinghorn, Harriet; And Others

    By studying the lives, important achievements, and works of famous artists, students may come to understand what those artists hoped to communicate to the world. By participating in art activities that are related to these artists' styles, students practice skills of observing, analyzing, and creating. This instructional guide provides…

  9. Mining functional relationships in feature subspaces from gene expression profiles and drug activity profiles.

    PubMed

    Bao, Lei; Guo, Tao; Sun, Zhirong

    2002-04-10

    In an effort to determine putative functional relationships between gene expression patterns and drug activity patterns of 60 human cancer cell lines, a novel method was developed to discover local associations within cell line subsets. The association of drug-gene pairs is an explorative way of discovering gene markers that predict clinical tumor sensitivity to therapy. Nine drug-gene networks were discovered, as well as dozens of gene-gene and drug-drug networks. Three drug-gene networks with well studied members were discussed and the literature shows that hypothetical functional relationships exist. Therefore, this method enables the gathering of new information beyond global associations.

  10. Testing of an actively damped boring bar featuring structurally integrated PZT stack actuators

    SciTech Connect

    Redmond, J.; Barney, P.

    1998-06-01

    This paper summarizes the results of cutting tests performed using an actively damped boring bar to minimize chatter in metal cutting. A commercially available 2 inch diameter boring bar was modified to incorporate PZT stack actuators for controlling tool bending vibrations encountered during metal removal. The extensional motion of the actuators induce bending moments in the host structure through a two-point preloaded mounting scheme. Cutting tests performed at various speeds and depths of cuts on a hardened steel workpiece illustrate the bar`s effectiveness toward eliminating chatter vibrations and improving workpiece surface finish.

  11. Purification, structure features and anti-atherosclerosis activity of a Laminaria japonica polysaccharide.

    PubMed

    Peng, Fu-Hua; Zha, Xue-Qiang; Cui, Shao-Hua; Asghar, Muhammad-Naeem; Pan, Li-Hua; Wang, Jun-Hui; Luo, Jian-Ping

    2015-11-01

    A homogeneous polysaccharide (LJP12) was isolated from Laminaria japonica by diethylaminoethyl-cellulose and Sephacryl S-500 chromatography, with a molecular weight of 2.31×10(6)Da. Monosaccharide analysis showed that LJP12 was mainly composed of arabinose, xylose, mannose, glucose and galactose in a molar ratio of 1:0.17:1.54:2.64:0.18. For these monosaccharides, mannose was suggested to be 1,4-linked and 1,3,6-linked while glucose was linked by 1,6-glycosidic bond. The xylose, arabinose and galactose were suggested to be the terminal residues. To study the effects of LJP12 on protecting against atherosclerosis, LJP12 was administered to LDL receptor-deficient (LDLr(-/-)) mice (50, 100 and 200mg/kg/day, n=30 for each experimental group). Results showed that LJP12 exhibited the ability to inhibit high-fat-cholesterol diet (HFD)-induced formation of atherosclerotic plaques and plasma lipid levels in a dose-dependent manner. Meanwhile, both the HFD-induced systemic inflammation and local inflammation at the site of atherosclerotic lesion were significantly attenuated by LJP12, which were accompanied by the suppression of the activation of nuclear factor kappa-B (NF-κB) and mitogen-activated protein kinases (MAPKs) signaling pathways. Taken together, we concluded that long-term oral administration of LJP12 protects against atherosclerosis in LDLr(-/-) mice via inhibiting NF-κB/MAPKs-mediated inflammatory responses.

  12. Distinct structural features of TFAM drive mitochondrial DNA packaging versus transcriptional activation.

    PubMed

    Ngo, Huu B; Lovely, Geoffrey A; Phillips, Rob; Chan, David C

    2014-01-01

    TFAM (transcription factor A, mitochondrial) is a DNA-binding protein that activates transcription at the two major promoters of mitochondrial DNA (mtDNA)--the light strand promoter (LSP) and the heavy strand promoter 1 (HSP1). Equally important, it coats and packages the mitochondrial genome. TFAM has been shown to impose a U-turn on LSP DNA; however, whether this distortion is relevant at other sites is unknown. Here we present crystal structures of TFAM bound to HSP1 and to nonspecific DNA. In both, TFAM similarly distorts the DNA into a U-turn. Yet, TFAM binds to HSP1 in the opposite orientation from LSP explaining why transcription from LSP requires DNA bending, whereas transcription at HSP1 does not. Moreover, the crystal structures reveal dimerization of DNA-bound TFAM. This dimerization is dispensable for DNA bending and transcriptional activation but is important in DNA compaction. We propose that TFAM dimerization enhances mitochondrial DNA compaction by promoting looping of the DNA.

  13. [Features of brain oscillatory activity and cardiac defense in treatment arterial hypertensives].

    PubMed

    Aftanas, L I; Brak, I V; Gilinskaia, O M; Pavlov, S V; Reva, N V

    2014-01-01

    Stress reactivity of the motivational system of defense can be assessed with the aid the cardiac defense response (CDR) - the reaction of the cardiovascular system to unexpected aversive unconditioned stimulus. The main objective of the study was revealing putative contribution of oscillatory systems of the brain into central pathogenic mechanisms of enhanced blood pressure (BP) stress-reactivity in naive patients with arterial hypertension (AH) of the 1st-2nd degrees (n = 17) and healthy control (n = 19) subjects. Using dynamic registration "beat-by-beat" arterial pressure, and oscillatory activity related EEG (64 channels) is estimated using the event-related synchronization/desynchronization (ERD/ERS). Along with abnormally high blood pressure in patients with hypertension background set significantly lower concentrations of serotonin blood platelets and increased tonic activation of the left hemisphere, reflected in the asymmetric reduction of delta- (2-4 Hz) and theta-1 (4-6 Hz) power in the central and parietal cortex in the hemisphere CDR of the patients are characterized by hyperactivity both short- and long-latency components of blood pressure. According to the dynamic analysis of the concomitant EEG, long-latency BP components may be accounted by, among other mechanisms, weakening of the descending ("top-down") inhibitory control, hypothetically implemented with the high-frequency EEG alpha (10-12 Hz) oscillations from the medial central-parietal cortex of both hemispheres of the brain. PMID:25464727

  14. Initial heats of H{sub 2}S adsorption on activated carbons: Effect of surface features

    SciTech Connect

    Bagreev, A.; Adib, F.; Bandosz, T.J.

    1999-11-15

    The sorption of hydrogen sulfide was studied on activated carbons of various origins by means of inverse gas chromatography at infinite dilution. The conditions of the experiment were dry and anaerobic. Prior to the experiments the surface of some carbon samples was oxidized using either nitric acid or ammonium persulfate. Then the structural parameters of carbons were evaluated from the sorption of nitrogen. From the IGC experiments at various temperatures, heats of adsorption were calculated. The results showed that the heat of H{sub 2}S adsorption under dry anaerobic conditions does not depend on surface chemistry. The dependence of the heat of adsorption on the characteristic energy of nitrogen adsorption calculated from the Dubinin-Raduskevich equation was found. This correlation can be used to predict the heat of H{sub 2}S adsorption based on the results obtained from nitrogen adsorption.

  15. Performance analysis of a semi-active railway vehicle suspension featuring MR dampers

    NASA Astrophysics Data System (ADS)

    Kim, Hwan-Choong; Choi, Seung-Bok; Lee, Gyu-Seop; An, Chae-Hun; You, Won-Hee

    2014-03-01

    This paper presents performance analysis of semi-active railway vehicle suspension system using MR damper. In order to achieve this goal, a mathematical dynamic model of railway vehicle is derived by integrating car body, bogie frame and wheel-set which can be able to represent lateral, yaw and roll motion. Based on this model, the dynamic range of MR damper at the railway secondary suspension system and design parameters of MR damper are calculated. Subsequently, control performances of railway vehicle including car body lateral motion and acceleration of MR damper are evaluated through computer simulations. Then, the MR damper is manufactured to be retrofitted with the real railway vehicle and its characteristics are experimentally measured. Experimental performance of MR damper is assessed using test rig which is composed of a car body and two bogies.

  16. Crevasse-squeeze ridge corridors: Diagnostic features of late-stage palaeo-ice stream activity

    NASA Astrophysics Data System (ADS)

    Evans, David J. A.; Storrar, Robert D.; Rea, Brice R.

    2016-04-01

    A 200-km-long and 10-km-wide linear assemblage of till-filled geometrical ridges on the bed of the Maskwa palaeo-ice stream of the late Wisconsinan southwest Laurentide Ice Sheet are interpreted as crevasse-squeeze ridges (CSR) developed during internal flow unit reorganization, immediately prior to ice stream shutdown. Ridge orientations are predominantly orientated WNW-ESE, with a subordinate WSW-ENE alignment, both indicative of ice fracture development transverse to former ice stream flow, as indicated by NNE-SSW aligned MSGL. Subglacial till injection into basal and/or full depth, mode I and II crevasses occurred at the approximate centreline of the ice stream, in response to extension and fracturing. Landform preservation indicates that this took place during the final stages of ice streaming, immediately prior to ice stream shutdown. This linear zone of ice fracturing therefore likely represents the narrowing of the fast-flowing trunk, similar to the plug flow identified in some surging valley glaciers. Lateral drag between the final active flow unit and the slower moving ice on either side is likely recorded by the up-ice bending of the CSR limbs. The resulting CSR corridor, here related to an individual ice stream flow unit, constitutes a previously unreported style of crevasse infilling and contrasts with two existing CSR patterns: (1) wide arcuate zones of CSRs related to widespread fracturing within glacier surge lobes; and (2) narrow concentric arcs of CSRs and recessional push moraines related to submarginal till deformation at active temperate glacier lobes.

  17. Can Confirmatory Biopsy be Omitted in Prostate Cancer Active Surveillance Patients with Favorable Diagnostic Features?

    PubMed Central

    Satasivam, Prassannah; Poon, Bing Ying; Ehdaie, Behfar; Vickers, Andrew J.; Eastham, James A.

    2016-01-01

    Purpose We evaluated whether initial diagnostic parameters could predict the confirmatory biopsy result in patients initiating active surveillance for prostate cancer, to determine whether some men at low risk of reclassification could be spared unnecessary biopsy. Materials and Methods The cohort included 392 men with Gleason 6 prostate cancer on initial biopsy undergoing confirmatory biopsy. We used univariate and multivariable logistic regression to assess if high-grade cancer (Gleason ≥ 7) on confirmatory biopsy could be predicted from initial diagnostic parameters (prostate-specific antigen density, magnetic resonance imaging result, percent positive cores, percent cancer in positive cores, and total tumor length). Results Median age was 62 years (IQR 56–66) and 47% of patients were found to have a dominant or focal lesion on magnetic resonance imaging. Of the 392 patients, 44 (11%) were found to have high-grade cancer on confirmatory biopsy, among whom 39 had 3+4, 1 had 4+3, 3 had Gleason 8, and 1 patient had Gleason 9 disease. All predictors were significantly associated with high-grade cancer at confirmatory biopsy on univariate analysis. However, in the multivariable model only prostate-specific antigen density and total tumor length were significantly associated (AUC of 0.85). Using this model to select patients for confirmatory biopsy would generally provide a higher net benefit than performing confirmatory biopsy in all patients, across a wide range of threshold probabilities. Conclusion If externally validated, a model based on initial diagnostic criteria could be used to avoid confirmatory biopsy in many patients initiating active surveillance. PMID:26192258

  18. More target features in visual working memory leads to poorer search guidance: evidence from contralateral delay activity.

    PubMed

    Schmidt, Joseph; MacNamara, Annmarie; Proudfit, Greg Hajcak; Zelinsky, Gregory J

    2014-01-01

    The visual-search literature has assumed that the top-down target representation used to guide search resides in visual working memory (VWM). We directly tested this assumption using contralateral delay activity (CDA) to estimate the VWM load imposed by the target representation. In Experiment 1, observers previewed four photorealistic objects and were cued to remember the two objects appearing to the left or right of central fixation; Experiment 2 was identical except that observers previewed two photorealistic objects and were cued to remember one. CDA was measured during a delay following preview offset but before onset of a four-object search array. One of the targets was always present, and observers were asked to make an eye movement to it and press a button. We found lower magnitude CDA on trials when the initial search saccade was directed to the target (strong guidance) compared to when it was not (weak guidance). This difference also tended to be larger shortly before search-display onset and was largely unaffected by VWM item-capacity limits or number of previews. Moreover, the difference between mean strong- and weak-guidance CDA was proportional to the increase in search time between mean strong-and weak-guidance trials (as measured by time-to-target and reaction-time difference scores). Contrary to most search models, our data suggest that trials resulting in the maintenance of more target features results in poor search guidance to a target. We interpret these counterintuitive findings as evidence for strong search guidance using a small set of highly discriminative target features that remain after pruning from a larger set of features, with the load imposed on VWM varying with this feature-consolidation process. PMID:24599946

  19. More target features in visual working memory leads to poorer search guidance: evidence from contralateral delay activity.

    PubMed

    Schmidt, Joseph; MacNamara, Annmarie; Proudfit, Greg Hajcak; Zelinsky, Gregory J

    2014-03-05

    The visual-search literature has assumed that the top-down target representation used to guide search resides in visual working memory (VWM). We directly tested this assumption using contralateral delay activity (CDA) to estimate the VWM load imposed by the target representation. In Experiment 1, observers previewed four photorealistic objects and were cued to remember the two objects appearing to the left or right of central fixation; Experiment 2 was identical except that observers previewed two photorealistic objects and were cued to remember one. CDA was measured during a delay following preview offset but before onset of a four-object search array. One of the targets was always present, and observers were asked to make an eye movement to it and press a button. We found lower magnitude CDA on trials when the initial search saccade was directed to the target (strong guidance) compared to when it was not (weak guidance). This difference also tended to be larger shortly before search-display onset and was largely unaffected by VWM item-capacity limits or number of previews. Moreover, the difference between mean strong- and weak-guidance CDA was proportional to the increase in search time between mean strong-and weak-guidance trials (as measured by time-to-target and reaction-time difference scores). Contrary to most search models, our data suggest that trials resulting in the maintenance of more target features results in poor search guidance to a target. We interpret these counterintuitive findings as evidence for strong search guidance using a small set of highly discriminative target features that remain after pruning from a larger set of features, with the load imposed on VWM varying with this feature-consolidation process.

  20. Study of Fractal Features of Geomagnetic Activity Through an MHD Shell Model

    NASA Astrophysics Data System (ADS)

    Dominguez, M.; Nigro, G.; Munoz, V.; Carbone, V.

    2013-12-01

    Studies on complexity have been of great interest in plasma physics, because they provide new insights and reveal possible universalities on issues such as geomagnetic activity, turbulence in laboratory plasmas, physics of the solar wind, etc. [1, 2]. In particular, various studies have discussed the relationship between the fractal dimension, as a measure of complexity, and physical processes in magnetized plasmas such as the Sun's surface, the solar wind and the Earth's magnetosphere, including the possibility of forecasting geomagnetic activity [3, 4, 5]. Shell models are low dimensional dynamical models describing the main statistical properties of magnetohydrodynamic (MHD) turbulence [6]. These models allow us to describe extreme parameter conditions hence reaching very high Reynolds (Re) numbers. In this work a MHD shell model is used to describe the dissipative events which are taking place in the Earth's magnetosphere and causing geomagnetic storms. The box-counting fractal dimension (D) [7] is calculated for the time series of the magnetic energy dissipation rate obtained in this MHD shell model. We analyze the correlation between D and the energy dissipation rate in order to make a comparison with the same analysis made on the geomagnetic data. We show that, depending on the values of the viscosity and the diffusivity, the fractal dimension and the occurrence of bursts exhibit correlations similar as those observed in geomagnetic and solar data, [8] suggesting that the latter parameters could play a fundamental role in these processes. References [1] R. O. Dendy, S. C. Chapman, and M. Paczuski, Plasma Phys. Controlled Fusion 49, A95 (2007). [2] T. Chang and C. C. Wu, Phys. Rev. E 77, 045401 (2008). [3] R. T. J. McAteer, P. T. Gallagher, and J. Ireland, Astrophys. J. 631, 628 (2005). [4] V. M. Uritsky, A. J. Klimas, and D. Vassiliadis, Adv. Space Res. 37, 539 (2006). [5] S. C. Chapman, B. Hnat, and K. Kiyani, Nonlinear Proc. Geophys. 15, 445 (2008). [6] G

  1. What's New on MedlinePlus: Announcements and Special Features

    MedlinePlus

    ... this page: https://medlineplus.gov/whatsnew.html What's New: Announcements and Special Features To use the sharing ... a comprehensive, comparative study recently published in the New England Journal of Medicine ... Other Features Latest Health ...

  2. Structural features and antitumor activity of a novel polysaccharide from alkaline extract of Phellinus linteus mycelia.

    PubMed

    Pei, Juan-Juan; Wang, Zhen-Bin; Ma, Hai-Le; Yan, Jing-Kun

    2015-01-22

    A novel high molecular weight polysaccharide (PL-N1) was isolated from alkaline extract of the cultured Phellinus linteus mycelia. The weight average molecular weight (Mw) of PL-N1 was estimated at 343,000kDa. PL-N1 comprised arabinose, xylose, glucose, and galactose in the molar ratio of 4.0:6.7:1.3:1.0. The chemical structure of PL-N1 was investigated by FTIR and NMR spectroscopies and methylation analysis. The results showed that the backbone of PL-N1 comprised (1→4)-linked β-D-xylopyranosyl residues, (1→2)-linked α-D-xylopyranosyl residues, (1→4)-linked α-D-glucopyranosyl residues, (1→5)-linked β-D-arabinofuranosyl residues, (1→4)-linked β-D-xylopyranosyl residues which branched at O-2, and (1→4)-linked β-D-galactopyranosyl residues which branched at O-6. The branches consisted of (1→)-linked α-D-arabinofuranosyl residues. Antitumor activity assay in vitro showed that PL-N1 could inhibit the growth of HepG2 cells to a certain extent in a dose-dependent manner. Thus, PL-N1 may be developed as a potential, natural antitumor agent and functional food.

  3. Notch is active in Langerhans cell histiocytosis and confers pathognomonic features on dendritic cells.

    PubMed

    Hutter, Caroline; Kauer, Max; Simonitsch-Klupp, Ingrid; Jug, Gunhild; Schwentner, Raphaela; Leitner, Judith; Bock, Peter; Steinberger, Peter; Bauer, Wolfgang; Carlesso, Nadia; Minkov, Milen; Gadner, Helmut; Stingl, Georg; Kovar, Heinrich; Kriehuber, Ernst

    2012-12-20

    Langerhans cell histiocytosis (LCH) is an enigmatic disease defined by the accumulation of Langerhans cell-like dendritic cells (DCs). In the present study, we demonstrate that LCH cells exhibit a unique transcription profile that separates them not only from plasmacytoid and myeloid DCs, but also from epidermal Langerhans cells, indicating a distinct DC entity. Molecular analysis revealed that isolated and tissue-bound LCH cells selectively express the Notch ligand Jagged 2 (JAG2) and are the only DCs that express both Notch ligand and its receptor. We further show that JAG2 signaling induces key LCH-cell markers in monocyte-derived DCs, suggesting a functional role of Notch signaling in LCH ontogenesis. JAG2 also induced matrix-metalloproteinases 1 and 12, which are highly expressed in LCH and may account for tissue destruction in LCH lesions. This induction was selective for DCs and was not recapitulated in monocytes. The results of the present study suggest that JAG2-mediated Notch activation confers phenotypic and functional aspects of LCH to DCs; therefore, interference with Notch signaling may be an attractive strategy to combat this disease.

  4. Structural features of Escherichia coli heat-stable enterotoxin that activates membrane-associated guanylyl cyclase.

    PubMed

    Sato, T; Shimonishi, Y

    2004-03-01

    Heat-stable enterotoxin (ST), a small peptide of 18 or 19 amino acid residues produced by enterotoxigenic Escherichia coli, is the cause of acute diarrhea in infants and travelers in developing countries. ST triggers a biological response by binding to a membrane-associated guanylyl cyclase C (GC-C) which is located on intestinal epithelial cell membranes. This binding causes an increase in the concentration of cGMP as a second messenger in cells and activates protein kinase A and cystic fibrosis transmembrane conductance regulator. Here we describe the crystal structure of an ST at 0.89 A resolution. The molecule has a ring-shaped molecular architecture consisting of six peptide molecules with external and internal diameters of approximately 35 and 7 A, respectively and a thickness of approximately 11 A. The conserved residues at the central portion of ST are distributed on the outer surface of the ring-shaped peptide hexamer, suggesting that the hexamer may be implicated in the association with GC-C through these invariant residues. PMID:15049831

  5. The structural features of hemicelluloses dissolved out at different cooking stages of active oxygen cooking process.

    PubMed

    Shi, Jianbin; Yang, Qiulin; Lin, Lu

    2014-04-15

    This work described the morphologic changes of corn stalk and the structural characterization of its hemicelluloses dissolved in yellow liquor at different cooking stages. The results showed that active oxygen cooking process was an efficient method to depolymerize the corn stalk into cellulose, hemicelluloses, and lignin as a pretreatment of biomass conversion. This cooking process can also be divided into three phases: bulk delignification, extended delignification, and residual delignification. During the heating-up period 57.67% of hemicelluloses and 62.31% of lignin were removed from the raw material. However, only 15% of hemicelluloses and 23.21% of lignin were removed during at temperature' period. The hemicelluloses from the corn stalk and yellow liquor were composed of (1→4)-β-D-xylopyranose backbones substituted with α-l-arabinofuranosyl, 4-O-methyl-α-D-glucuronic acid, and some methoxyl residues. The backbones of hemicelluloses were gradually cleaved during the cooking process. The acetyl groups substituted with xylopyranosyl residues were completely cleaved during the cooking process.

  6. Feature activated molecular dynamics: an efficient approach for atomistic simulation of solid-state aggregation phenomena.

    PubMed

    Prasad, Manish; Sinno, Talid

    2004-11-01

    An efficient approach is presented for performing efficient molecular dynamics simulations of solute aggregation in crystalline solids. The method dynamically divides the total simulation space into "active" regions centered about each minority species, in which regular molecular dynamics is performed. The number, size, and shape of these regions is updated periodically based on the distribution of solute atoms within the overall simulation cell. The remainder of the system is essentially static except for periodic rescaling of the entire simulation cell in order to balance the pressure between the isolated molecular dynamics regions. The method is shown to be accurate and robust for the Environment-Dependant Interatomic Potential (EDIP) for silicon and an Embedded Atom Method potential (EAM) for copper. Several tests are performed beginning with the diffusion of a single vacancy all the way to large-scale simulations of vacancy clustering. In both material systems, the predicted evolutions agree closely with the results of standard molecular dynamics simulations. Computationally, the method is demonstrated to scale almost linearly with the concentration of solute atoms, but is essentially independent of the total system size. This scaling behavior allows for the full dynamical simulation of aggregation under conditions that are more experimentally realizable than would be possible with standard molecular dynamics.

  7. Anthelmintic Activities against Haemonchus contortus or Trichostrongylus colubriformis from Small Ruminants Are Influenced by Structural Features of Condensed Tannins.

    PubMed

    Quijada, Jessica; Fryganas, Christos; Ropiak, Honorata M; Ramsay, Aina; Mueller-Harvey, Irene; Hoste, Hervé

    2015-07-22

    Plants containing condensed tannins (CTs) may hold promise as alternatives to synthetic anthelmintic (AH) drugs for controlling gastrointestinal nematodes (GINs). However, the structural features that contribute to the AH activities of CTs remain elusive. This study probed the relationships between CT structures and their AH activities. Eighteen plant resources were selected on the basis of their diverse CT structures. From each plant resource, two CT fractions were isolated and their in vitro AH activities were measured with the larval exsheathment inhibition assay, which was applied to Haemonchus contortus and Trichostrongylus colubriformis. Calculation of mean EC50 values indicated that H. contortus was more susceptible than T. colubriformis to the different fractions and that the F1 fractions were less efficient than the F2 ones, as indicated by the respective mean values for H. contortus, F1 = 136.9 ± 74.1 μg/mL and F2 = 108.1 ± 53.2 μg/mL, and for T. colubriformis, F1 = 233 ± 54.3 μg/mL and F2 = 166 ± 39.9 μg/mL. The results showed that the AH activity against H. contortus was associated with the monomeric subunits that give rise to prodelphinidins (P < 0.05) and with CT polymer size (P < 0.10). However, for T. colubriformis AH activity was correlated only with prodelphinidins (P < 0.05). These results suggest that CTs have different modes of action against different parasite species.

  8. Developing a web page: bringing clinics online.

    PubMed

    Peterson, Ronnie; Berns, Susan

    2004-01-01

    Introducing clinical staff education, along with new policies and procedures, to over 50 different clinical sites can be a challenge. As any staff educator will confess, getting people to attend an educational inservice session can be difficult. Clinical staff request training, but no one has time to attend training sessions. Putting the training along with the policies and other information into "neat" concise packages via the computer and over the company's intranet was the way to go. However, how do you bring the clinics online when some of the clinical staff may still be reluctant to turn on their computers for anything other than to gather laboratory results? Developing an easy, fun, and accessible Web page was the answer. This article outlines the development of the first training Web page at the University of Wisconsin Medical Foundation, Madison, WI.

  9. Featured Article: Teriflunomide, an immunomodulatory drug, exerts anticancer activity in triple negative breast cancer cells

    PubMed Central

    Huang, Ou; Zhang, Weili; Zhi, Qiaoming; Xue, Xiaofeng; Liu, Hongchun; Shen, Daoming; Geng, Meiyu; Xie, Zuoquan

    2015-01-01

    Triple-negative breast cancer (TNBC) is defined as a group of primary breast cancers lacking expression of estrogen, progesterone, and human epidermal growth factor receptor-2 (HER-2) receptors, characterized by higher relapse rate and lower survival compared with other subtypes. Due to lack of identified targets and molecular heterogeneity, conventional chemotherapy is the only available option for treatment of TNBC, but non-discordant positive therapeutic efficacy could not be achieved. Here, we demonstrated that these TNBC cells were sensitive to teriflunomide, which was a well-known immunomodulatory drug for treatment of relapsing multiple sclerosis (MS). Potent anti-cancer effects in TNBC in vitro, including proliferation inhibition, cell cycle delay, cell apoptosis, and suppression of cell motility and invasiveness, could be achieved with this agent. Of note, we showed that multiple signals involved in TNBC proliferation, survival, migratory, and invasive potential were under regulation by teriflunomide. Among them, we identified down-regulation of growth factor receptors to abolish growth maintenance, suppression of c-Myc, and cyclin D1 to contribute to its anti-proliferative effect, modulation of components of cell cycle to induce S-phase arrest, degradation of Bcl-xL, and up-regulation of BAX via activation of MAPK pathway to induce apoptosis, and inhibition of epithelial-mesenchymal transition (EMT) process, matrix metalloproteinase-9 (MMP9) expression, and inactivation of Src/FAK to reduce TNBC migration and invasion. The results identified teriflunomide may be of therapeutic benefit for the more aggressive and difficult-to-treat breast cancer subtype, indicating the use of teriflunomide for clinical trials for treatment of TNBC patients. PMID:25304315

  10. Resistance to Degradation and Cellular Distribution are Important Features for the Antitumor Activity of Gomesin

    PubMed Central

    Buri, Marcus V.; Domingues, Tatiana M.; Paredes-Gamero, Edgar J.; Casaes-Rodrigues, Rafael L.; Rodrigues, Elaine Guadelupe; Miranda, Antonio

    2013-01-01

    Many reports have shown that antimicrobial peptides exhibit anticancer abilities. Gomesin (Gm) exhibits potent cytotoxic activity against cancer cells by a membrane pore formation induced after well-orchestrated intracellular mechanisms. In this report, the replacements of the Cys by Ser or Thr, and the use D-amino acids in the Gm structure were done to investigate the importance of the resistance to degradation of the molecule with its cytotoxicity. [Thr2,6,11,15]-Gm, and [Ser2,6,11,15]-Gm exhibits low cytotoxicity, and low resistance to degradation, and after 24 h are present in localized area near to the membrane. Conversely, the use of D-amino acids in the analogue [D-Thr2,6,11,15]-D-Gm confers resistance to degradation, increases its potency, and maintained this peptide spread in the cytosol similarly to what happens with Gm. Replacements of Cys by Thr and Gln by L- or D-Pro ([D-Thr2,6,11,15, Pro9]-D-Gm, and [Thr2,6,11,15, D-Pro9]-Gm), which induced a similar β-hairpin conformation, also increase their resistance to degradation, and cytotoxicity, but after 24 h they are not present spread in the cytosol, exhibiting lower cytotoxicity in comparison to Gm. Additionally, chloroquine, a lysosomal enzyme inhibitor potentiated the effect of the peptides. Furthermore, the binding and internalization of peptides was determined, but a direct correlation among these factors was not observed. However, cholesterol ablation, which increase fluidity of cellular membrane, also increase cytotoxicity and internalization of peptides. β-hairpin spatial conformation, and intracellular localization/target, and the capability of entry are important properties of gomesin cytotoxicity. PMID:24312251

  11. Structural Features and Chaperone Activity of the NudC Protein Family

    SciTech Connect

    Zheng, Meiying; Cierpicki, Tomasz; Burdette, Alexander J.; Utepbergenov, Darkhan; Janczyk, Pawe; #322; #321; .; Derewenda, Urszula; Stukenberg, P. Todd; Caldwell, Kim A.; Derewenda, Zygmunt S.

    2012-05-25

    The NudC family consists of four conserved proteins with representatives in all eukaryotes. The archetypal nudC gene from Aspergillus nidulans is a member of the nud gene family that is involved in the maintenance of nuclear migration. This family also includes nudF, whose human orthologue, Lis1, codes for a protein essential for brain cortex development. Three paralogues of NudC are known in vertebrates: NudC, NudC-like (NudCL), and NudC-like 2 (NudCL2). The fourth distantly related member of the family, CML66, contains a NudC-like domain. The three principal NudC proteins have no catalytic activity but appear to play as yet poorly defined roles in proliferating and dividing cells. We present crystallographic and NMR studies of the human NudC protein and discuss the results in the context of structures recently deposited by structural genomics centers (i.e., NudCL and mouse NudCL2). All proteins share the same core CS domain characteristic of proteins acting either as cochaperones of Hsp90 or as independent small heat shock proteins. However, while NudC and NudCL dimerize via an N-terminally located coiled coil, the smaller NudCL2 lacks this motif and instead dimerizes as a result of unique domain swapping. We show that NudC and NudCL, but not NudCL2, inhibit the aggregation of several target proteins, consistent with an Hsp90-independent heat shock protein function. Importantly, and in contrast to several previous reports, none of the three proteins is able to form binary complexes with Lis1. The availability of structural information will be of help in further studies on the cellular functions of the NudC family.

  12. Insights into Facebook Pages: an early adolescent health research study page targeted at parents.

    PubMed

    Amon, Krestina L; Paxton, Karen; Klineberg, Emily; Riley, Lisa; Hawke, Catherine; Steinbeck, Katharine

    2016-02-01

    Facebook has been used in health research, but there is a lack of literature regarding how Facebook may be used to recruit younger adolescents. A Facebook Page was created for an adolescent cohort study on the effects of puberty hormones on well-being and behaviour in early adolescence. Used as a communication tool with existing participants, it also aimed to alert potential participants to the study. The purpose of this paper is to provide a detailed description of the development of the study Facebook Page and present the fan response to the types of posts made on the Page using the Facebook-generated Insights data. Two types of posts were made on the study Facebook Page. The first type was study-related update posts and events. The second was relevant adolescent and family research and current news posts. Observations on the use of and response to the Page were made over 1 year across three phases (phase 1, very low Facebook use; phase 2, high Facebook use; phase 3, low Facebook use). Most Page fans were female (88.6%), with the largest group of fans aged between 35 and 44 years. Study-related update posts with photographs were the most popular. This paper provides a model on which other researchers could base Facebook communication and potential recruitment in the absence of established guidelines. PMID:25781667

  13. Insights into Facebook Pages: an early adolescent health research study page targeted at parents.

    PubMed

    Amon, Krestina L; Paxton, Karen; Klineberg, Emily; Riley, Lisa; Hawke, Catherine; Steinbeck, Katharine

    2016-02-01

    Facebook has been used in health research, but there is a lack of literature regarding how Facebook may be used to recruit younger adolescents. A Facebook Page was created for an adolescent cohort study on the effects of puberty hormones on well-being and behaviour in early adolescence. Used as a communication tool with existing participants, it also aimed to alert potential participants to the study. The purpose of this paper is to provide a detailed description of the development of the study Facebook Page and present the fan response to the types of posts made on the Page using the Facebook-generated Insights data. Two types of posts were made on the study Facebook Page. The first type was study-related update posts and events. The second was relevant adolescent and family research and current news posts. Observations on the use of and response to the Page were made over 1 year across three phases (phase 1, very low Facebook use; phase 2, high Facebook use; phase 3, low Facebook use). Most Page fans were female (88.6%), with the largest group of fans aged between 35 and 44 years. Study-related update posts with photographs were the most popular. This paper provides a model on which other researchers could base Facebook communication and potential recruitment in the absence of established guidelines.

  14. The Impact of Salient Advertisements on Reading and Attention on Web Pages

    ERIC Educational Resources Information Center

    Simola, Jaana; Kuisma, Jarmo; Oorni, Anssi; Uusitalo, Liisa; Hyona, Jukka

    2011-01-01

    Human vision is sensitive to salient features such as motion. Therefore, animation and onset of advertisements on Websites may attract visual attention and disrupt reading. We conducted three eye tracking experiments with authentic Web pages to assess whether (a) ads are efficiently ignored, (b) ads attract overt visual attention and disrupt…

  15. Perspectives on the consecutive pages problem

    NASA Astrophysics Data System (ADS)

    Srinivasan, V. K.

    2011-04-01

    This article presents different approaches to a problem, dubbed by the author as 'the consecutive pages problem'. The aim of this teaching-oriented article is to promote the teaching of abstract concepts in mathematics, by selecting a challenging amusement problem and then presenting various solutions in such a way that it can engage the attention of a fourth-grade student, a high school senior student, an average college student and scholars.

  16. THE DISK EVAPORATION MODEL FOR THE SPECTRAL FEATURES OF LOW-LUMINOSITY ACTIVE GALACTIC NUCLEI

    SciTech Connect

    Qiao, Erlin; Liu, B. F.; Panessa, Francesca; Liu, J. Y.

    2013-11-10

    Observations show that the accretion flows in low-luminosity active galactic nuclei probably have a two-component structure with an inner, hot, optically thin, advection-dominated accretion flow (ADAF) and an outer, truncated, cool, optically thick accretion disk. As shown by Taam et al., the truncation radius as a function of mass accretion rate is strongly affected by including the magnetic field within the framework of disk evaporation model, i.e., an increase in the magnetic field results in a smaller truncation radius of the accretion disk. In this work, we calculate the emergent spectrum of an inner ADAF + an outer truncated accretion disk around a supermassive black hole based on the prediction by Taam et al.. It is found that an increase in the magnetic field from β = 0.8 to β = 0.5 (with magnetic pressure p{sub m} = B {sup 2}/8π = (1 – β)p{sub tot}, p{sub tot} = p{sub gas} + p{sub m}) results in a factor of ∼8.7 increase in the luminosity from the truncated accretion disk. Meanwhile, results of the peak emission of the truncated accretion disk shift toward a a factor of ∼5 higher frequency. We found that the equipartition of gas pressure to magnetic pressure, i.e., β = 0.5, failed to explain the observed anti-correlation between L{sub 2-10{sub keV}}/L{sub Edd} and the bolometric correction κ{sub 2-10{sub keV}} (with κ{sub 2-10{sub keV}} = L{sub bol}/L{sub 2-10{sub keV}}). The emergent spectra for larger values of β = 0.8 or β = 0.95 can explain the observed L{sub 2-10{sub keV}}/L{sub Edd}-κ{sub 2-10{sub keV}} correlation. We argue that in the disk evaporation model, the electrons in the corona are assumed to be heated only by a transfer of energy from the ions to electrons via Coulomb collisions, which is reasonable for accretion with a lower mass accretion rate. Coulomb heating is the dominated heating mechanism for the electrons only if the magnetic field is strongly sub-equipartition, which is roughly consistent with observations.

  17. Erk1/2 activity promotes chromatin features and RNAPII phosphorylation at developmental promoters in mouse ESCs.

    PubMed

    Tee, Wee-Wei; Shen, Steven S; Oksuz, Ozgur; Narendra, Varun; Reinberg, Danny

    2014-02-13

    Erk1/2 activation contributes to mouse ES cell pluripotency. We found a direct role of Erk1/2 in modulating chromatin features required for regulated developmental gene expression. Erk2 binds to specific DNA sequence motifs typically accessed by Jarid2 and PRC2. Negating Erk1/2 activation leads to increased nucleosome occupancy and decreased occupancy of PRC2 and poised RNAPII at Erk2-PRC2-targeted developmental genes. Surprisingly, Erk2-PRC2-targeted genes are specifically devoid of TFIIH, known to phosphorylate RNA polymerase II (RNAPII) at serine-5, giving rise to its initiated form. Erk2 interacts with and phosphorylates RNAPII at its serine 5 residue, which is consistent with the presence of poised RNAPII as a function of Erk1/2 activation. These findings underscore a key role for Erk1/2 activation in promoting the primed status of developmental genes in mouse ES cells and suggest that the transcription complex at developmental genes is different than the complexes formed at other genes, offering alternative pathways of regulation.

  18. Controlling misses and false alarms in a machine learning framework for predicting uniformity of printed pages

    NASA Astrophysics Data System (ADS)

    Nguyen, Minh Q.; Allebach, Jan P.

    2015-01-01

    In our previous work1 , we presented a block-based technique to analyze printed page uniformity both visually and metrically. The features learned from the models were then employed in a Support Vector Machine (SVM) framework to classify the pages into one of the two categories of acceptable and unacceptable quality. In this paper, we introduce a set of tools for machine learning in the assessment of printed page uniformity. This work is primarily targeted to the printing industry, specifically the ubiquitous laser, electrophotographic printer. We use features that are well-correlated with the rankings of expert observers to develop a novel machine learning framework that allows one to achieve the minimum "false alarm" rate, subject to a chosen "miss" rate. Surprisingly, most of the research that has been conducted on machine learning does not consider this framework. During the process of developing a new product, test engineers will print hundreds of test pages, which can be scanned and then analyzed by an autonomous algorithm. Among these pages, most may be of acceptable quality. The objective is to find the ones that are not. These will provide critically important information to systems designers, regarding issues that need to be addressed in improving the printer design. A "miss" is defined to be a page that is not of acceptable quality to an expert observer that the prediction algorithm declares to be a "pass". Misses are a serious problem, since they represent problems that will not be seen by the systems designers. On the other hand, "false alarms" correspond to pages that an expert observer would declare to be of acceptable quality, but which are flagged by the prediction algorithm as "fails". In a typical printer testing and development scenario, such pages would be examined by an expert, and found to be of acceptable quality after all. "False alarm" pages result in extra pages to be examined by expert observers, which increases labor cost. But "false

  19. Do not hesitate to use Tversky-and other hints for successful active analogue searches with feature count descriptors.

    PubMed

    Horvath, Dragos; Marcou, Gilles; Varnek, Alexandre

    2013-07-22

    This study is an exhaustive analysis of the neighborhood behavior over a large coherent data set (ChEMBL target/ligand pairs of known Ki, for 165 targets with >50 associated ligands each). It focuses on similarity-based virtual screening (SVS) success defined by the ascertained optimality index. This is a weighted compromise between purity and retrieval rate of active hits in the neighborhood of an active query. One key issue addressed here is the impact of Tversky asymmetric weighing of query vs candidate features (represented as integer-value ISIDA colored fragment/pharmacophore triplet count descriptor vectors). The nearly a 3/4 million independent SVS runs showed that Tversky scores with a strong bias in favor of query-specific features are, by far, the most successful and the least failure-prone out of a set of nine other dissimilarity scores. These include classical Tanimoto, which failed to defend its privileged status in practical SVS applications. Tversky performance is not significantly conditioned by tuning of its bias parameter α. Both initial "guesses" of α = 0.9 and 0.7 were more successful than Tanimoto (at its turn, better than Euclid). Tversky was eventually tested in exhaustive similarity searching within the library of 1.6 M commercial + bioactive molecules at http://infochim.u-strasbg.fr/webserv/VSEngine.html , comparing favorably to Tanimoto in terms of "scaffold hopping" propensity. Therefore, it should be used at least as often as, perhaps in parallel to Tanimoto in SVS. Analysis with respect to query subclasses highlighted relationships of query complexity (simply expressed in terms of pharmacophore pattern counts) and/or target nature vs SVS success likelihood. SVS using more complex queries are more robust with respect to the choice of their operational premises (descriptors, metric). Yet, they are best handled by "pro-query" Tversky scores at α > 0.5. Among simpler queries, one may distinguish between "growable" (allowing for active

  20. Change in hippocampal theta activity with transfer from simple discrimination tasks to a simultaneous feature-negative task

    PubMed Central

    Sakimoto, Yuya; Sakata, Shogo

    2014-01-01

    It was showed that solving a simple discrimination task (A+, B−) and a simultaneous feature-negative (FN) task (A+, AB−) used the hippocampal-independent strategy. Recently, we showed that the number of sessions required for a rat to completely learn a task differed between the FN and simple discrimination tasks, and there was a difference in hippocampal theta activity between these tasks. These results suggested that solving the FN task relied on a different strategy than the simple discrimination task. In this study, we provided supportive evidence that solving the FN and simple discrimination tasks involved different strategies by examining changes in performance and hippocampal theta activity in the FN task after transfer from the simple discrimination task (A+, B− → A+, AB−). The results of this study showed that performance on the FN task was impaired and there was a difference in hippocampal theta activity between the simple discrimination task and FN task. Thus, we concluded that solving the FN task uses a different strategy than the simple discrimination task. PMID:24917797

  1. Clonal B cells in Waldenström's macroglobulinemia exhibit functional features of chronic active B-cell receptor signaling

    PubMed Central

    Argyropoulos, K V; Vogel, R; Ziegler, C; Altan-Bonnet, G; Velardi, E; Calafiore, M; Dogan, A; Arcila, M; Patel, M; Knapp, K; Mallek, C; Hunter, Z R; Treon, S P; van den Brink, M R M; Palomba, M L

    2016-01-01

    Waldenström's macroglobulinemia (WM) is a B-cell non-Hodgkin's lymphoma (B-NHL) characterized by immunoglobulin M (IgM) monoclonal gammopathy and the medullary expansion of clonal lymphoplasmacytic cells. Neoplastic transformation has been partially attributed to hyperactive MYD88 signaling, secondary to the MYD88 L265P mutation, occurring in the majority of WM patients. Nevertheless, the presence of chronic active B-cell receptor (BCR) signaling, a feature of multiple IgM+ B-NHL, remains a subject of speculation in WM. Here, we interrogated the BCR signaling capacity of primary WM cells by utilizing multiparametric phosphoflow cytometry and found heightened basal phosphorylation of BCR-related signaling proteins, and augmented phosphoresponses on surface IgM (sIgM) crosslinking, compared with normal B cells. In support of those findings we observed high sIgM expression and loss of phosphatase activity in WM cells, which could both lead to signaling potentiation in clonal cells. Finally, led by the high-signaling heterogeneity among WM samples, we generated patient-specific phosphosignatures, which subclassified patients into a ‘high' and a ‘healthy-like' signaling group, with the second corresponding to patients with a more indolent clinical phenotype. These findings support the presence of chronic active BCR signaling in WM while providing a link between differential BCR signaling utilization and distinct clinical WM subgroups. PMID:26867669

  2. Wellness Partners: Design and Evaluation of a Web-Based Physical Activity Diary with Social Gaming Features for Adults

    PubMed Central

    Wang, Hua; Spruijt-Metz, Donna; Jordan-Marsh, Maryalice; Valente, Thomas William

    2013-01-01

    Background The United States is currently in an age of obesity and inactivity despite increasing public awareness and scientific knowledge of detrimental long-term health effects of this lifestyle. Behavior-tracking diaries offer an effective strategy for physical activity adherence and weight management. Furthermore, Web-based physical activity diaries can engage meaningful partners in people’s social networks through fun online gaming interactions and generate motivational mechanisms for effective behavioral change and positive health outcomes. Objective Wellness Partners (WP) is a Web-based intervention in the form of a physical activity diary with social networking and game features. Two versions were designed and developed for the purpose of this study—“Diary” only and “Diary+Game”. The objectives of this study included pilot testing the research process of this intervention design, implementation, evaluation, and exploring the effectiveness of social gaming features on adult participants’ physical activity and anthropometric measures. Methods We conducted a field experiment with randomized crossover design. Assessments occurred at baseline, first follow-up (FU, 5-8 weeks after using one version of WP), and second FU (5-8 weeks of using the other version of WP). In the control condition, participants started with the “Diary” version of WP while in the experimental condition, participants started with the “Diary+Game” version of WP. A total of 54 adults (egos) ages 44-88, and their family and friends (alters) ages 17-69 participated in the study in ego-network groups. Both egos and their alters completed online surveys about their exercise habits. In addition, egos completed anthropometric measurements of BMI, fat percentage, and fat mass by bioimpedance. Results From October 2009 to May 2010, flyers, emails, and Web advertisements yielded 335 volunteers who were screened. Rolling recruitment resulted in enrollment of 142 qualified

  3. 46. Photograph of a published page. 'OPERATIONS IN INCORPORATION BUILDINGS: ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    46. Photograph of a published page. 'OPERATIONS IN INCORPORATION BUILDINGS: HOLSTON DEFENSE CORPORATION. 'HOLSTON ARMY AMMUNITION PLANT.' Page 17. (no date). - Holston Army Ammunition Plant, RDX-and-Composition-B Manufacturing Line 9, Kingsport, Sullivan County, TN

  4. 45. Photograph of a published page. OPERATIONS IN 'H' OR ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    45. Photograph of a published page. OPERATIONS IN 'H' OR DEWATERING BUILDING: HOLSTON DEFENSE CORPORATION. 'HOLSTON ARMY AMMUNITION PLANT.' Page 16. (no date). - Holston Army Ammunition Plant, RDX-and-Composition-B Manufacturing Line 9, Kingsport, Sullivan County, TN

  5. Classroom Web Pages: A "How-To" Guide for Educators.

    ERIC Educational Resources Information Center

    Fehling, Eric E.

    This manual provides teachers, with very little or no technology experience, with a step-by-step guide for developing the necessary skills for creating a class Web Page. The first part of the manual is devoted to the thought processes preceding the actual creation of the Web Page. These include looking at other Web Pages, deciding what should be…

  6. World Wide Web Pages--Tools for Teaching and Learning.

    ERIC Educational Resources Information Center

    Beasley, Sarah; Kent, Jean

    Created to help educators incorporate World Wide Web pages into teaching and learning, this collection of Web pages presents resources, materials, and techniques for using the Web. The first page focuses on tools for teaching and learning via the Web, providing pointers to sites containing the following: (1) course materials for both distance and…

  7. Young Children's Interpretations of Page Breaks in Contemporary Picture Storybooks

    ERIC Educational Resources Information Center

    Sipe, Lawrence R.; Brightman, Anne E.

    2009-01-01

    This article reports on a study of the responses of a second-grade class to the page breaks in contemporary picturebooks. In a picturebook, the text and accompanying illustrations are divided into a series of facing pages called openings, and the divisions between the openings are called page breaks or turns. Unlike a novel, in which the page…

  8. Digital Ethnography: Library Web Page Redesign among Digital Natives

    ERIC Educational Resources Information Center

    Klare, Diane; Hobbs, Kendall

    2011-01-01

    Presented with an opportunity to improve Wesleyan University's dated library home page, a team of librarians employed ethnographic techniques to explore how its users interacted with Wesleyan's current library home page and web pages in general. Based on the data that emerged, a group of library staff and members of the campus' information…

  9. Required Discussion Web Pages in Psychology Courses and Student Outcomes

    ERIC Educational Resources Information Center

    Pettijohn, Terry F., II; Pettijohn, Terry F.

    2007-01-01

    We conducted 2 studies that investigated student outcomes when using discussion Web pages in psychology classes. In Study 1, we assigned 213 students enrolled in Introduction to Psychology courses to either a mandatory or an optional Web page discussion condition. Students used the discussion Web page significantly more often and performed…

  10. Emphasizing Social Features in Information Portals: Effects on New Member Engagement

    PubMed Central

    Sharma, Nikhil; Butler, Brian S.; Irwin, Jeannie; Spallek, Heiko

    2013-01-01

    Many information portals are adding social features with hopes of enhancing the overall user experience. Invitations to join and welcome pages that highlight these social features are expected to encourage use and participation. While this approach is widespread and seems plausible, the effect of providing and highlighting social features remains to be tested. We studied the effects of emphasizing social features on users' response to invitations, their decisions to join, their willingness to provide profile information, and their engagement with the portal's social features. The results of a quasi-experiment found no significant effect of social emphasis in invitations on receivers' responsiveness. However, users receiving invitations highlighting social benefits were less likely to join the portal and provide profile information. Social emphasis in the initial welcome page for the site also was found to have a significant effect on whether individuals joined the portal, how much profile information they provided and shared, and how much they engaged with social features on the site. Unexpectedly, users who were welcomed in a social manner were less likely to join and provided less profile information; they also were less likely to engage with social features of the portal. This suggests that even in online contexts where social activity is an increasingly common feature, highlighting the presence of social features may not always be the optimal presentation strategy. PMID:23626487

  11. Emphasizing Social Features in Information Portals: Effects on New Member Engagement.

    PubMed

    Sharma, Nikhil; Butler, Brian S; Irwin, Jeannie; Spallek, Heiko

    2011-11-01

    Many information portals are adding social features with hopes of enhancing the overall user experience. Invitations to join and welcome pages that highlight these social features are expected to encourage use and participation. While this approach is widespread and seems plausible, the effect of providing and highlighting social features remains to be tested. We studied the effects of emphasizing social features on users' response to invitations, their decisions to join, their willingness to provide profile information, and their engagement with the portal's social features. The results of a quasi-experiment found no significant effect of social emphasis in invitations on receivers' responsiveness. However, users receiving invitations highlighting social benefits were less likely to join the portal and provide profile information. Social emphasis in the initial welcome page for the site also was found to have a significant effect on whether individuals joined the portal, how much profile information they provided and shared, and how much they engaged with social features on the site. Unexpectedly, users who were welcomed in a social manner were less likely to join and provided less profile information; they also were less likely to engage with social features of the portal. This suggests that even in online contexts where social activity is an increasingly common feature, highlighting the presence of social features may not always be the optimal presentation strategy. PMID:23626487

  12. Facebook's personal page modelling and simulation

    NASA Astrophysics Data System (ADS)

    Sarlis, Apostolos S.; Sakas, Damianos P.; Vlachos, D. S.

    2015-02-01

    In this paper we will try to define the utility of Facebook's Personal Page marketing method. This tool that Facebook provides, is modelled and simulated using iThink in the context of a Facebook marketing agency. The paper has leveraged the system's dynamic paradigm to conduct Facebook marketing tools and methods modelling, using iThink™ system to implement them. It uses the design science research methodology for the proof of concept of the models and modelling processes. The following model has been developed for a social media marketing agent/company, Facebook platform oriented and tested in real circumstances. This model is finalized through a number of revisions and iterators of the design, development, simulation, testing and evaluation processes. The validity and usefulness of this Facebook marketing model for the day-to-day decision making are authenticated by the management of the company organization. Facebook's Personal Page method can be adjusted, depending on the situation, in order to maximize the total profit of the company which is to bring new customers, keep the interest of the old customers and deliver traffic to its website.

  13. Design of a Web Page as a complement of educative innovation through MOODLE

    NASA Astrophysics Data System (ADS)

    Mendiola Ubillos, M. A.; Aguado Cortijo, Pedro L.

    2010-05-01

    In the context of Information Technology to impart knowledge and to establish MOODLE system as a support and complementary tool to on-site educational methodology (b-learning) a Web Page was designed in Agronomic and Food Industry Crops (Plantas de interés Agroalimentario) during 2006-07 course. This web was inserted in the Thecnical University of Madrid (Universidad Politécnica de Madrid) computer system to facilitate to the students the first contact with the contents of this subject. In this page the objectives and methodology, personal work planning, subject program given plus the activities are showed. At another web site, the evaluation criteria and recommended bibliography are located. The objective of this web page has been to make more transparent and accessible the necessary information in the learning process and presenting it in a more attractive frame. This page has been update and modified in each academic course offered since its first implementation. We had added in some cases new specific links to increase its useful. At the end of each course a test is applied to the students that take this subject. We have asked which elements would like to modify, delete and add to this web page. In this way the direct users give their point of view and help to improve the web page each course.

  14. Lifting Events in RDF from Interactions with Annotated Web Pages

    NASA Astrophysics Data System (ADS)

    Stühmer, Roland; Anicic, Darko; Sen, Sinan; Ma, Jun; Schmidt, Kay-Uwe; Stojanovic, Nenad

    In this paper we present a method and an implementation for creating and processing semantic events from interaction with Web pages which opens possibilities to build event-driven applications for the (Semantic) Web. Events, simple or complex, are models for things that happen e.g., when a user interacts with a Web page. Events are consumed in some meaningful way e.g., for monitoring reasons or to trigger actions such as responses. In order for receiving parties to understand events e.g., comprehend what has led to an event, we propose a general event schema using RDFS. In this schema we cover the composition of complex events and event-to-event relationships. These events can then be used to route semantic information about an occurrence to different recipients helping in making the Semantic Web active. Additionally, we present an architecture for detecting and composing events in Web clients. For the contents of events we show a way of how they are enriched with semantic information about the context in which they occurred. The paper is presented in conjunction with the use case of Semantic Advertising, which extends traditional clickstream analysis by introducing semantic short-term profiling, enabling discovery of the current interest of a Web user and therefore supporting advertisement providers in responding with more relevant advertisements.

  15. Neighbourhoods for Active Kids: study protocol for a cross-sectional examination of neighbourhood features and children's physical activity, active travel, independent mobility and body size

    PubMed Central

    Oliver, Melody; McPhee, Julia; Carroll, Penelope; Ikeda, Erika; Mavoa, Suzanne; Mackay, Lisa; Kearns, Robin A; Kyttä, Marketta; Asiasiga, Lanuola; Garrett, Nicholas; Lin, Judy; Mackett, Roger; Zinn, Caryn; Moewaka Barnes, Helen; Egli, Victoria; Prendergast, Kate; Witten, Karen

    2016-01-01

    Introduction New Zealand children's physical activity, including independent mobility and active travel, has declined markedly over recent decades. The Neighbourhoods for Active Kids (NfAK) study examines how neighbourhood built environments are associated with the independent mobility, active travel, physical activity and neighbourhood experiences of children aged 9–12 years in primary and intermediate schools across Auckland, New Zealand's largest city. Methods and analysis Child-specific indices of walkability, destination accessibility and traffic exposure will be constructed to measure the built environment in 8 neighbourhoods in Auckland. Interactive online-mapping software will be used to measure children's independent mobility and transport mode to destinations and to derive measures of neighbourhood use and perceptions. Physical activity will be measured using 7-day accelerometry. Height, weight and waist circumference will be objectively measured. Parent telephone interviews will collect sociodemographic information and parent neighbourhood perceptions. Interviews with school representative will capture supports and barriers for healthy activity and nutrition behaviours at the school level. Multilevel modelling approaches will be used to understand how differing built environment variables are associated with activity, neighbourhood experiences and health outcomes. Discussion We anticipate that children who reside in neighbourhoods considered highly walkable will be more physically active, accumulate more independent mobility and active travel, and be more likely to have a healthy body size. This research is timely as cities throughout New Zealand develop and implement plans to improve the liveability of intensifying urban neighbourhoods. Results will be disseminated to participants, local government agencies and through conventional academic avenues. PMID:27531740

  16. Synthesis of the quaternary in the almeria littoral neotectonic activity and its morphologic features, western betics, Spain

    NASA Astrophysics Data System (ADS)

    Goy, J. L.; Zazo, C.

    1986-11-01

    A sequence of marine and continental Quaternary episodes is established, as are their interrelationships. The zone's tectonics have, in most cases, remained active to the present and control the factors All the Tyrrhenian levels containing Strombus bubonius are affected by the many faults that cross the lateral fringe and continue onto the shelf. Among these are: the Loma del Viento Fault, (N120°E. a normal fault with certain leftward characteristics): the El Alquian faults (N140°, 160°E, which coincide, according to several authors (Bousquet, 1979), with the surface feature of a great dextral deep accident); and the Carboneras Fault, or the Serrata Fault, (N40°, 45°E, left strike-slip fault). Given the varying behaviour of the shoreline, we have chosen to divide it into four sectors: Campo de Dalias, El-Alquian-Cabo de Gata, Mojacar—Garrucha. and Campo de Nijar-Serrata. Due to its geographical location, no marine-continental relationships exist in the latter. A chart has been made in an attempt to synthesize the most significant stratigraphic, genetic and tectonic characteristics of each sector. Lastly, the influence of tectonics on the distribution and heights of the Quaternary shorelines is clearly shown in a chart of the transgressive maxima of the Tyrrhenian episodes.

  17. Evaluation of image features and search strategies for segmentation of bone structures in radiographs using Active Shape Models.

    PubMed

    Behiels, Gert; Maes, Frederik; Vandermeulen, Dirk; Suetens, Paul

    2002-03-01

    In this paper, we evaluate various image features and different search strategies for fitting Active Shape Models (ASM) to bone object boundaries in digitized radiographs. The original ASM method iteratively refines the pose and shape parameters of the point distribution model driving the ASM by a least squares fit of the shape to update the target points at the estimated object boundary position, as determined by a suitable object boundary criterion. We propose an improved search procedure that is more robust against outlier configurations in the boundary target points by requiring subsequent shape changes to be smooth, which is imposed by a smoothness constraint on the displacement of neighbouring target points at each iteration and implemented by a minimal cost path approach. We compare the original ASM search method and our improved search algorithm with a third method that does not rely on iteratively refined target point positions, but instead optimizes a global Bayesian objective function derived from statistical a priori contour shape and image models. Extensive validation of these methods on a database containing more than 400 images of the femur, humerus and calcaneus using the manual expert segmentation as ground truth shows that our minimal cost path method is the most robust. We also evaluate various measures for capturing local image appearance around each boundary point and conclude that the Mahalanobis distance applied to normalized image intensity profiles extracted normal to the shape is the most suitable criterion among the tested ones for guiding the ASM optimization. PMID:11836134

  18. Predicting Pathological Features at Radical Prostatectomy in Patients with Prostate Cancer Eligible for Active Surveillance by Multiparametric Magnetic Resonance Imaging

    PubMed Central

    de Cobelli, Ottavio; Terracciano, Daniela; Tagliabue, Elena; Raimondi, Sara; Bottero, Danilo; Cioffi, Antonio; Jereczek-Fossa, Barbara; Petralia, Giuseppe; Cordima, Giovanni; Almeida, Gilberto Laurino; Lucarelli, Giuseppe; Buonerba, Carlo; Matei, Deliu Victor; Renne, Giuseppe; Di Lorenzo, Giuseppe; Ferro, Matteo

    2015-01-01

    Purpose The aim of this study was to investigate the prognostic performance of multiparametric magnetic resonance imaging (mpMRI) and Prostate Imaging Reporting and Data System (PIRADS) score in predicting pathologic features in a cohort of patients eligible for active surveillance who underwent radical prostatectomy. Methods A total of 223 patients who fulfilled the criteria for “Prostate Cancer Research International: Active Surveillance”, were included. Mp–1.5 Tesla MRI examination staging with endorectal coil was performed at least 6–8 weeks after TRUS-guided biopsy. In all patients, the likelihood of the presence of cancer was assigned using PIRADS score between 1 and 5. Outcomes of interest were: Gleason score upgrading, extra capsular extension (ECE), unfavorable prognosis (occurrence of both upgrading and ECE), large tumor volume (≥0.5ml), and seminal vesicle invasion (SVI). Receiver Operating Characteristic (ROC) curves and Decision Curve Analyses (DCA) were performed for models with and without inclusion of PIRADS score. Results Multivariate analysis demonstrated the association of PIRADS score with upgrading (P<0.0001), ECE (P<0.0001), unfavorable prognosis (P<0.0001), and large tumor volume (P = 0.002). ROC curves and DCA showed that models including PIRADS score resulted in greater net benefit for almost all the outcomes of interest, with the only exception of SVI. Conclusions mpMRI and PIRADS scoring are feasible tools in clinical setting and could be used as decision-support systems for a more accurate selection of patients eligible for AS. PMID:26444548

  19. Use of quantitative shape-activity relationships to model the photoinduced toxicity of polycyclic aromatic hydrocarbons: Electron density shape features accurately predict toxicity

    SciTech Connect

    Mezey, P.G.; Zimpel, Z.; Warburton, P.; Walker, P.D.; Irvine, D.G.; Huang, X.D.; Dixon, D.G.; Greenberg, B.M.

    1998-07-01

    The quantitative shape-activity relationship (QShAR) methodology, based on accurate three-dimensional electron densities and detailed shape analysis methods, has been applied to a Lemna gibba photoinduced toxicity data set of 16 polycyclic aromatic hydrocarbon (PAH) molecules. In the first phase of the studies, a shape fragment QShAR database of PAHs was developed. The results provide a very good match to toxicity based on a combination of the local shape features of single rings in comparison to the central ring of anthracene and a more global shape feature involving larger molecular fragments. The local shape feature appears as a descriptor of the susceptibility of PAHs to photomodification and the global shape feature is probably related to photosensitization activity.

  20. College of DuPage Information Technology Plan, Fiscal Year 1994-95.

    ERIC Educational Resources Information Center

    College of DuPage, Glen Ellyn, IL.

    Building upon four previous planning documents for computing at College of DuPage in Illinois, this plan for fiscal year 1995 (FY95) provides a starting point for future plans to address all activities that relate to the use of information technology on campus. The FY95 "Information Technology Plan" is divided into six sections, each providing an…

  1. Multibeam Mapping of Active Slope Instability Features: Examples from the Fraser River and Squamish River Deltas, British Columbia, Canada

    NASA Astrophysics Data System (ADS)

    Hill, P. R.

    2004-12-01

    Multibeam mapping of the coastal waters of British Columbia has immensly improved our ability to identify and assess submarine landslide and tsunami hazard. This paper will present analysis of high-resolution images of slope instability features from two delta slopes where recent slope failure can be documented through repetitive multibeam mapping and/or comparison with previous single-beam hydrographic soundings. Numerous mass movement features characterize the slope of the Fraser River delta, all the recent features being located at the mouths of distributary channels. Engineering works have maintained the main channel in a fixed position since the 1930's, contributing to over-steepening of the slope and development of a network of submarine channels. Repetitive multibeam mapping shows that recent slope failures have occurred in numerous locations around the main channel lobe, some at the head of a large submarine channel system and others as isolated small failures that form the headwalls of small submarine channels. The scalloped morphology and association with channels, together with volume estimates derived from repetitive multibeam mapping, indicate that these features result from shallow, small volume liquefaction failures. Smaller scale, shallow slides are present on the very shallow water slope area adjacent to the channels, raising the possibility of groundwater seepage as an influence on slope stability. The slide masses from these failures are rapidly transformed into gravity flows that carve the submarine channels. Slides and channels of a similar scale are found at the mouth of a secondary distributary channel and an abandoned distributary channel. The multibeam imagery allows discrimination between recent slide features and relict features, the latter showing infilling or reworking by bottom currents. An area of undulatory seafloor, located on the flank of the main distributary channel lobe, has been cited as a possible creep displacement feature

  2. 48 CFR 1852.215-81 - Proposal page limitations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Proposal page limitations. 1852.215-81 Section 1852.215-81 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE... 1852.215-81 Proposal page limitations. As prescribed in 1815.209-70(d), insert the following...

  3. The Library as Information Provider: The Home Page.

    ERIC Educational Resources Information Center

    Clyde, Laurel A.

    1996-01-01

    Discusses ways in which libraries are using the World Wide Web to provide information via a home page, based on information from a survey in Iceland as well as a larger study that conducted content analyses of home pages of public and school libraries in 13 countries. (Author/LRW)

  4. Toward a User-Centered Academic Library Home Page

    ERIC Educational Resources Information Center

    McHale, Nina

    2008-01-01

    In the past decade, academic libraries have struggled with the design of an effective library home page. Since librarians' mental models of information architecture differ from those of their patrons, usability assessments are necessary in designing a user-centered home page. This study details a usability sequence of card sort and paper and…

  5. Paging and Scrolling: Cognitive Styles in Learning from Hypermedia

    ERIC Educational Resources Information Center

    Eyuboglu, Filiz; Orhan, Feza

    2011-01-01

    This study investigates the navigational patterns and learning achievement of university students with different cognitive styles, on hypermedia learning environments using paging or scrolling. The global-local subscales of Sternberg's Thinking Styles Inventory, two hypermedia, one using paging, the other using scrolling, a multiple choice…

  6. JavaScript: Convenient Interactivity for the Class Web Page.

    ERIC Educational Resources Information Center

    Gray, Patricia

    This paper shows how JavaScript can be used within HTML pages to add interactive review sessions and quizzes incorporating graphics and sound files. JavaScript has the advantage of providing basic interactive functions without the use of separate software applications and players. Because it can be part of a standard HTML page, it is…

  7. Evaluating Information Quality: Hidden Biases on the Children's Web Pages

    ERIC Educational Resources Information Center

    Kurubacak, Gulsun

    2006-01-01

    As global digital communication continues to flourish, the Children's Web pages become more critical for children to realize not only the surface but also breadth and deeper meanings in presenting these milieus. These pages not only are very diverse and complex but also enable intense communication across social, cultural and political…

  8. World Wide Web Page Design: A Structured Approach.

    ERIC Educational Resources Information Center

    Gregory, Gwen; Brown, M. Marlo

    1997-01-01

    Describes how to develop a World Wide Web site based on structured programming concepts. Highlights include flowcharting, first page design, evaluation, page titles, documenting source code, text, graphics, and browsers. Includes a template for HTML writers, tips for using graphics, a sample homepage, guidelines for authoring structured HTML, and…

  9. New Cloud Activity on Uranus in 2004: First Detection of a Southern Feature at 2.2 microns

    SciTech Connect

    Hammel, H B; de Pater, I; Gibbard, S; Lockwood, G; Rages, K

    2005-02-02

    On 4 July 2004 UT, we detected one of Uranus' southern hemispheric features at K' (2.2 {micro}m); this is the first such detection in half a decade of adaptive optics imaging of Uranus at the Keck 10-m telescope. When we observed again on 8 July UT the core had faded, and by 9 July UT it was not seen at K' and barely detectable at H. The detection and subsequent disappearance of the feature indicates rapid dynamical processes in the localized vertical aerosol structure.

  10. Adobe InDesign vs. QuarkXPress and PageMaker: The Best of Both Worlds?

    ERIC Educational Resources Information Center

    Wilson, Bradley

    2000-01-01

    Evaluates the newly released Adobe InDesign software, finding that while it brings new life into desktop publishing, it is not yet a "must buy" for publications advisers. Compares specific features that are relevant for student publications, including: character, paragraph, drop caps, define styles, page setup, text wrap, defining and using…

  11. Optimizing TLB entries for mixed page size storage in contiguous memory

    DOEpatents

    Chen, Dong; Gara, Alan; Giampapa, Mark E.; Heidelberger, Philip; Kriegel, Jon K.; Ohmacht, Martin; Steinmacher-Burow, Burkhard

    2013-04-30

    A system and method for accessing memory are provided. The system comprises a lookup buffer for storing one or more page table entries, wherein each of the one or more page table entries comprises at least a virtual page number and a physical page number; a logic circuit for receiving a virtual address from said processor, said logic circuit for matching the virtual address to the virtual page number in one of the page table entries to select the physical page number in the same page table entry, said page table entry having one or more bits set to exclude a memory range from a page.

  12. Geographically Modified PageRank Algorithms: Identifying the Spatial Concentration of Human Movement in a Geospatial Network.

    PubMed

    Chin, Wei-Chien-Benny; Wen, Tzai-Hung

    2015-01-01

    A network approach, which simplifies geographic settings as a form of nodes and links, emphasizes the connectivity and relationships of spatial features. Topological networks of spatial features are used to explore geographical connectivity and structures. The PageRank algorithm, a network metric, is often used to help identify important locations where people or automobiles concentrate in the geographical literature. However, geographic considerations, including proximity and location attractiveness, are ignored in most network metrics. The objective of the present study is to propose two geographically modified PageRank algorithms-Distance-Decay PageRank (DDPR) and Geographical PageRank (GPR)-that incorporate geographic considerations into PageRank algorithms to identify the spatial concentration of human movement in a geospatial network. Our findings indicate that in both intercity and within-city settings the proposed algorithms more effectively capture the spatial locations where people reside than traditional commonly-used network metrics. In comparing location attractiveness and distance decay, we conclude that the concentration of human movement is largely determined by the distance decay. This implies that geographic proximity remains a key factor in human mobility. PMID:26437000

  13. Geographically Modified PageRank Algorithms: Identifying the Spatial Concentration of Human Movement in a Geospatial Network

    PubMed Central

    2015-01-01

    A network approach, which simplifies geographic settings as a form of nodes and links, emphasizes the connectivity and relationships of spatial features. Topological networks of spatial features are used to explore geographical connectivity and structures. The PageRank algorithm, a network metric, is often used to help identify important locations where people or automobiles concentrate in the geographical literature. However, geographic considerations, including proximity and location attractiveness, are ignored in most network metrics. The objective of the present study is to propose two geographically modified PageRank algorithms—Distance-Decay PageRank (DDPR) and Geographical PageRank (GPR)—that incorporate geographic considerations into PageRank algorithms to identify the spatial concentration of human movement in a geospatial network. Our findings indicate that in both intercity and within-city settings the proposed algorithms more effectively capture the spatial locations where people reside than traditional commonly-used network metrics. In comparing location attractiveness and distance decay, we conclude that the concentration of human movement is largely determined by the distance decay. This implies that geographic proximity remains a key factor in human mobility. PMID:26437000

  14. Geographically Modified PageRank Algorithms: Identifying the Spatial Concentration of Human Movement in a Geospatial Network.

    PubMed

    Chin, Wei-Chien-Benny; Wen, Tzai-Hung

    2015-01-01

    A network approach, which simplifies geographic settings as a form of nodes and links, emphasizes the connectivity and relationships of spatial features. Topological networks of spatial features are used to explore geographical connectivity and structures. The PageRank algorithm, a network metric, is often used to help identify important locations where people or automobiles concentrate in the geographical literature. However, geographic considerations, including proximity and location attractiveness, are ignored in most network metrics. The objective of the present study is to propose two geographically modified PageRank algorithms-Distance-Decay PageRank (DDPR) and Geographical PageRank (GPR)-that incorporate geographic considerations into PageRank algorithms to identify the spatial concentration of human movement in a geospatial network. Our findings indicate that in both intercity and within-city settings the proposed algorithms more effectively capture the spatial locations where people reside than traditional commonly-used network metrics. In comparing location attractiveness and distance decay, we conclude that the concentration of human movement is largely determined by the distance decay. This implies that geographic proximity remains a key factor in human mobility.

  15. Judging a Book by Its Cover: An Investigation of Peritextual Features in Caldecott Award Books

    ERIC Educational Resources Information Center

    Martinez, Miriam; Stier, Catherine; Falcon, Lori

    2016-01-01

    While scholars have recognized the meaning making potential offered by the peritext of picturebooks, there has previously been only limited research on the nature of peritextual features. This content analysis focused on the ways in which various peritextual features (dust jackets, beginning endpapers, illustrations before title page, title pages,…

  16. One-Shot Decoupling and Page Curves from a Dynamical Model for Black Hole Evaporation.

    PubMed

    Brádler, Kamil; Adami, Christoph

    2016-03-11

    One-shot decoupling is a powerful primitive in quantum information theory and was hypothesized to play a role in the black hole information paradox. We study black hole dynamics modeled by a trilinear Hamiltonian whose semiclassical limit gives rise to Hawking radiation. An explicit numerical calculation of the discretized path integral of the S matrix shows that decoupling is exact in the continuous limit, implying that quantum information is perfectly transferred from the black hole to radiation. A striking consequence of decoupling is the emergence of an output radiation entropy profile that follows Page's prediction. We argue that information transfer and the emergence of Page curves is a robust feature of any multilinear interaction Hamiltonian with a bounded spectrum. PMID:27015471

  17. One-Shot Decoupling and Page Curves from a Dynamical Model for Black Hole Evaporation.

    PubMed

    Brádler, Kamil; Adami, Christoph

    2016-03-11

    One-shot decoupling is a powerful primitive in quantum information theory and was hypothesized to play a role in the black hole information paradox. We study black hole dynamics modeled by a trilinear Hamiltonian whose semiclassical limit gives rise to Hawking radiation. An explicit numerical calculation of the discretized path integral of the S matrix shows that decoupling is exact in the continuous limit, implying that quantum information is perfectly transferred from the black hole to radiation. A striking consequence of decoupling is the emergence of an output radiation entropy profile that follows Page's prediction. We argue that information transfer and the emergence of Page curves is a robust feature of any multilinear interaction Hamiltonian with a bounded spectrum.

  18. Eplerenone mimics features of the alternative activation in macrophages obtained from patients with heart failure and healthy volunteers.

    PubMed

    Łabuzek, Krzysztof; Liber, Sebastian; Bułdak, Łukasz; Krupej-Kędzierska, Joanna; Machnik, Grzegorz; Bobrzyk, Magdalena; Okopień, Bogusław

    2014-03-01

    Alternative activation of macrophages plays protective role in cardiac remodelling in heart failure and the activity of mineralocorticoid receptor may determine the phenotype of these cells. We examined the influence of eplerenone, aldosterone, and IL-4 on descriptors of alternative activation in blood monocytes collected from 19 patients with heart-failure and 20 healthy volunteers. “Heart failure” macrophages in comparison with “healthy” macrophages had increased mineralocorticoid activity, NO and reactive oxygen species production, expression of iNOS mRNA and protein, but decreased expression of arginase I and mannose receptor proteins, and activity of MnSOD and CuZnSOD. Aldosterone increased mineralocorticoid activity, NO and reactive oxygen species production, iNOS mRNA and protein expression, MnSOD and CuZnSOD activity. Eplerenone attenuated the effects of aldosterone on all but MnSOD and CuZnSOD variables. Eplerenone alone increased the production of NO, MnSOD and CuZnSOD activity, arginase I gene and protein expression, and mannose receptor gene and protein expression, but decreased mineralocorticoid activity only in “heart failure” macrophages. The latter suggests altered function of mineralocorticoid receptor in heart failure. Increased mineralocorticoid activity accounts for increased NO production, iNOS gene and protein expression but does not explain the increased basal reactive oxygen species production and decreased markers of alternative activation in “heart failure” macrophages. In the lack of change in basal mineralocorticoid activity, eplerenone increases markers of alternative activation in a mineralocorticoid receptor-independent manner. Because of changes in iNOS and NO variable, eplerenone induced qualitatively different activation of macrophages from that obtained with IL-4.

  19. An Efficient Web Page Ranking for Semantic Web

    NASA Astrophysics Data System (ADS)

    Chahal, P.; Singh, M.; Kumar, S.

    2014-01-01

    With the enormous amount of information presented on the web, the retrieval of relevant information has become a serious problem and is also the topic of research for last few years. The most common tools to retrieve information from web are search engines like Google. The Search engines are usually based on keyword searching and indexing of web pages. This approach is not very efficient as the result-set of web pages obtained include large irrelevant pages. Sometimes even the entire result-set may contain lot of irrelevant pages for the user. The next generation of search engines must address this problem. Recently, many semantic web search engines have been developed like Ontolook, Swoogle, which help in searching meaningful documents presented on semantic web. In this process the ranking of the retrieved web pages is very crucial. Some attempts have been made in ranking of semantic web pages but still the ranking of these semantic web documents is neither satisfactory and nor up to the user's expectations. In this paper we have proposed a semantic web based document ranking scheme that relies not only on the keywords but also on the conceptual instances present between the keywords. As a result only the relevant page will be on the top of the result-set of searched web pages. We explore all relevant relations between the keywords exploring the user's intention and then calculate the fraction of these relations on each web page to determine their relevance. We have found that this ranking technique gives better results than those by the prevailing methods.

  20. Exploring the use of a Facebook page in anatomy education.

    PubMed

    Jaffar, Akram Abood

    2014-01-01

    Facebook is the most popular social media site visited by university students on a daily basis. Consequently, Facebook is the logical place to start with for integrating social media technologies into education. This study explores how a faculty-administered Facebook Page can be used to supplement anatomy education beyond the traditional classroom. Observations were made on students' perceptions and effectiveness of using the Page, potential benefits and challenges of such use, and which Insights metrics best reflect user's engagement. The Human Anatomy Education Page was launched on Facebook and incorporated into anatomy resources for 157 medical students during two academic years. Students' use of Facebook and their perceptions of the Page were surveyed. Facebook's "Insights" tool was also used to evaluate Page performance during a period of 600 days. The majority of in-class students had a Facebook account which they adopted in education. Most students perceived Human Anatomy Education Page as effective in contributing to learning and favored "self-assessment" posts. The majority of students agreed that Facebook could be a suitable learning environment. The "Insights" tool revealed globally distributed fans with considerable Page interactions. The use of a faculty-administered Facebook Page provided a venue to enhance classroom teaching without intruding into students' social life. A wider educational use of Facebook should be adopted not only because students are embracing its use, but for its inherent potentials in boosting learning. The "Insights" metrics analyzed in this study might be helpful when establishing and evaluating the performance of education-oriented Facebook Pages.

  1. Exploring the use of a Facebook page in anatomy education.

    PubMed

    Jaffar, Akram Abood

    2014-01-01

    Facebook is the most popular social media site visited by university students on a daily basis. Consequently, Facebook is the logical place to start with for integrating social media technologies into education. This study explores how a faculty-administered Facebook Page can be used to supplement anatomy education beyond the traditional classroom. Observations were made on students' perceptions and effectiveness of using the Page, potential benefits and challenges of such use, and which Insights metrics best reflect user's engagement. The Human Anatomy Education Page was launched on Facebook and incorporated into anatomy resources for 157 medical students during two academic years. Students' use of Facebook and their perceptions of the Page were surveyed. Facebook's "Insights" tool was also used to evaluate Page performance during a period of 600 days. The majority of in-class students had a Facebook account which they adopted in education. Most students perceived Human Anatomy Education Page as effective in contributing to learning and favored "self-assessment" posts. The majority of students agreed that Facebook could be a suitable learning environment. The "Insights" tool revealed globally distributed fans with considerable Page interactions. The use of a faculty-administered Facebook Page provided a venue to enhance classroom teaching without intruding into students' social life. A wider educational use of Facebook should be adopted not only because students are embracing its use, but for its inherent potentials in boosting learning. The "Insights" metrics analyzed in this study might be helpful when establishing and evaluating the performance of education-oriented Facebook Pages. PMID:24022984

  2. Time-Frequency Feature Representation Using Multi-Resolution Texture Analysis and Acoustic Activity Detector for Real-Life Speech Emotion Recognition

    PubMed Central

    Wang, Kun-Ching

    2015-01-01

    The classification of emotional speech is mostly considered in speech-related research on human-computer interaction (HCI). In this paper, the purpose is to present a novel feature extraction based on multi-resolutions texture image information (MRTII). The MRTII feature set is derived from multi-resolution texture analysis for characterization and classification of different emotions in a speech signal. The motivation is that we have to consider emotions have different intensity values in different frequency bands. In terms of human visual perceptual, the texture property on multi-resolution of emotional speech spectrogram should be a good feature set for emotion classification in speech. Furthermore, the multi-resolution analysis on texture can give a clearer discrimination between each emotion than uniform-resolution analysis on texture. In order to provide high accuracy of emotional discrimination especially in real-life, an acoustic activity detection (AAD) algorithm must be applied into the MRTII-based feature extraction. Considering the presence of many blended emotions in real life, in this paper make use of two corpora of naturally-occurring dialogs recorded in real-life call centers. Compared with the traditional Mel-scale Frequency Cepstral Coefficients (MFCC) and the state-of-the-art features, the MRTII features also can improve the correct classification rates of proposed systems among different language databases. Experimental results show that the proposed MRTII-based feature information inspired by human visual perception of the spectrogram image can provide significant classification for real-life emotional recognition in speech. PMID:25594590

  3. Brain aneurysm segmentation in CTA and 3DRA using geodesic active regions based on second order prototype features and nonparametric density estimation

    NASA Astrophysics Data System (ADS)

    Hernandez, Monica; Frangi, Alejandro F.

    2005-04-01

    Coupling the geodesic active contours model with statistical information based on regions introduces robustness in the segmentation of images with weak or inhomogeneous gradients. In the estimation of the probability density function for each region take part the definition of the features that describe the image inside the different regions and the method of density estimation itself. A Gaussian Mixture Model is frequently proposed for density estimation. This approach is based on the assumption that the intensity distribution of the image is the most discriminant feature in a region. However, the use of second order features provides a better discrimination of the different regions, as these features represent more accurately the local properties of the image manifold. Due to the high dimensionality of the problem, the use of non parametric density estimation methods becomes necessary. In this article, we present a novel method of introducing the second order information of an image for non parametric estimation of the probability density functions of the different tissues that are present in medical images. The novelty of the method stems on the use of the response of the image under an orthogonal harmonic operator set projected onto a prototype space for feature generation. The technique described here is applied to the segmentation of brain aneurysms in Computed Tomography Angiography (CTA) and 3D Rotational Angiography (3DRA) showing a qualitative improvement from the Gaussian Mixture Model approach.

  4. Home Page: The Mode of Transport through the Information Superhighway

    NASA Technical Reports Server (NTRS)

    Lujan, Michelle R.

    1995-01-01

    The purpose of the project with the Aeroacoustics Branch was to create and submit a home page for the internet about branch information. In order to do this, one must also become familiar with the way that the internet operates. Learning HyperText Markup Language (HTML), and the ability to create a document using this language was the final objective in order to place a home page on the internet (World Wide Web). A manual of instructions regarding maintenance of the home page, and how to keep it up to date was also necessary in order to provide branch members with the opportunity to make any pertinent changes.

  5. Real-time evaluation of polyphenol oxidase (PPO) activity in lychee pericarp based on weighted combination of spectral data and image features as determined by fuzzy neural network.

    PubMed

    Yang, Yi-Chao; Sun, Da-Wen; Wang, Nan-Nan; Xie, Anguo

    2015-07-01

    A novel method of using hyperspectral imaging technique with the weighted combination of spectral data and image features by fuzzy neural network (FNN) was proposed for real-time prediction of polyphenol oxidase (PPO) activity in lychee pericarp. Lychee images were obtained by a hyperspectral reflectance imaging system operating in the range of 400-1000nm. A support vector machine-recursive feature elimination (SVM-RFE) algorithm was applied to eliminating variables with no or little information for the prediction from all bands, resulting in a reduced set of optimal wavelengths. Spectral information at the optimal wavelengths and image color features were then used respectively to develop calibration models for the prediction of PPO in pericarp during storage, and the results of two models were compared. In order to improve the prediction accuracy, a decision strategy was developed based on weighted combination of spectral data and image features, in which the weights were determined by FNN for a better estimation of PPO activity. The results showed that the combined decision model was the best among all of the calibration models, with high R(2) values of 0.9117 and 0.9072 and low RMSEs of 0.45% and 0.459% for calibration and prediction, respectively. These results demonstrate that the proposed weighted combined decision method has great potential for improving model performance. The proposed technique could be used for a better prediction of other internal and external quality attributes of fruits.

  6. Stimulus-related independent component and voxel-wise analysis of human brain activity during free viewing of a feature film.

    PubMed

    Lahnakoski, Juha M; Salmi, Juha; Jääskeläinen, Iiro P; Lampinen, Jouko; Glerean, Enrico; Tikka, Pia; Sams, Mikko

    2012-01-01

    Understanding how the brain processes stimuli in a rich natural environment is a fundamental goal of neuroscience. Here, we showed a feature film to 10 healthy volunteers during functional magnetic resonance imaging (fMRI) of hemodynamic brain activity. We then annotated auditory and visual features of the motion picture to inform analysis of the hemodynamic data. The annotations were fitted to both voxel-wise data and brain network time courses extracted by independent component analysis (ICA). Auditory annotations correlated with two independent components (IC) disclosing two functional networks, one responding to variety of auditory stimulation and another responding preferentially to speech but parts of the network also responding to non-verbal communication. Visual feature annotations correlated with four ICs delineating visual areas according to their sensitivity to different visual stimulus features. In comparison, a separate voxel-wise general linear model based analysis disclosed brain areas preferentially responding to sound energy, speech, music, visual contrast edges, body motion and hand motion which largely overlapped the results revealed by ICA. Differences between the results of IC- and voxel-based analyses demonstrate that thorough analysis of voxel time courses is important for understanding the activity of specific sub-areas of the functional networks, while ICA is a valuable tool for revealing novel information about functional connectivity which need not be explained by the predefined model. Our results encourage the use of naturalistic stimuli and tasks in cognitive neuroimaging to study how the brain processes stimuli in rich natural environments. PMID:22496909

  7. Stimulus-Related Independent Component and Voxel-Wise Analysis of Human Brain Activity during Free Viewing of a Feature Film

    PubMed Central

    Lahnakoski, Juha M.; Salmi, Juha; Jääskeläinen, Iiro P.; Lampinen, Jouko; Glerean, Enrico; Tikka, Pia; Sams, Mikko

    2012-01-01

    Understanding how the brain processes stimuli in a rich natural environment is a fundamental goal of neuroscience. Here, we showed a feature film to 10 healthy volunteers during functional magnetic resonance imaging (fMRI) of hemodynamic brain activity. We then annotated auditory and visual features of the motion picture to inform analysis of the hemodynamic data. The annotations were fitted to both voxel-wise data and brain network time courses extracted by independent component analysis (ICA). Auditory annotations correlated with two independent components (IC) disclosing two functional networks, one responding to variety of auditory stimulation and another responding preferentially to speech but parts of the network also responding to non-verbal communication. Visual feature annotations correlated with four ICs delineating visual areas according to their sensitivity to different visual stimulus features. In comparison, a separate voxel-wise general linear model based analysis disclosed brain areas preferentially responding to sound energy, speech, music, visual contrast edges, body motion and hand motion which largely overlapped the results revealed by ICA. Differences between the results of IC- and voxel-based analyses demonstrate that thorough analysis of voxel time courses is important for understanding the activity of specific sub-areas of the functional networks, while ICA is a valuable tool for revealing novel information about functional connectivity which need not be explained by the predefined model. Our results encourage the use of naturalistic stimuli and tasks in cognitive neuroimaging to study how the brain processes stimuli in rich natural environments. PMID:22496909

  8. [Changes in acetylcholinesterase and ATPase activity and certain structural features of the erythrocyte membrane in experimental myocardial ischemia].

    PubMed

    Chernukh, A M; Kopteva, L A; Shevchenko, A S

    1980-09-01

    Acute heart ischemia induced by ligation of the left coronary artery is associated with variation in the activity of acetylcholinesterase, Na, K-ATPase and Ca, Mg-ATPase in rat erythrocytes. The maximum pronounced variations in the enzymatic activity and in the membrane capacity of erythroblasts for binding direct turquoise are recorded on the 7th day of the experimental myocardial infarction.

  9. Incidental and Context-Responsive Activation of Structure- and Function-Based Action Features during Object Identification

    ERIC Educational Resources Information Center

    Lee, Chia-lin; Middleton, Erica; Mirman, Daniel; Kalenine, Solene; Buxbaum, Laurel J.

    2013-01-01

    Previous studies suggest that action representations are activated during object processing, even when task-irrelevant. In addition, there is evidence that lexical-semantic context may affect such activation during object processing. Finally, prior work from our laboratory and others indicates that function-based ("use") and structure-based…

  10. Characterization of the Etna volcanic emissions through an active biomonitoring technique (moss-bags): part 2--morphological and mineralogical features.

    PubMed

    Calabrese, S; D'Alessandro, W

    2015-01-01

    Volcanic emissions were studied at Mount Etna (Italy) by using moss-bags technique. Mosses were exposed around the volcano at different distances from the active vents to evaluate the impact of volcanic emissions in the atmosphere. Morphology and mineralogy of volcanic particulate intercepted by mosses were investigated using scanning electron microscopy (SEM) equipped with energy dispersive spectrometer (EDS). Particles emitted during passive degassing activity from the two active vents, Bocca Nuova and North East Crater (BNC and NEC), were identified as silicates, sulfates and halide compounds. In addition to volcanic particles, we found evidences also of geogenic, anthropogenic and marine spray input. The study has shown the robustness of this active biomonitoring technique to collect particles, very useful in active volcanic areas characterized by continuous degassing and often not easily accessible to apply conventional sampling techniques.

  11. Characterization of the Etna volcanic emissions through an active biomonitoring technique (moss-bags): part 2--morphological and mineralogical features.

    PubMed

    Calabrese, S; D'Alessandro, W

    2015-01-01

    Volcanic emissions were studied at Mount Etna (Italy) by using moss-bags technique. Mosses were exposed around the volcano at different distances from the active vents to evaluate the impact of volcanic emissions in the atmosphere. Morphology and mineralogy of volcanic particulate intercepted by mosses were investigated using scanning electron microscopy (SEM) equipped with energy dispersive spectrometer (EDS). Particles emitted during passive degassing activity from the two active vents, Bocca Nuova and North East Crater (BNC and NEC), were identified as silicates, sulfates and halide compounds. In addition to volcanic particles, we found evidences also of geogenic, anthropogenic and marine spray input. The study has shown the robustness of this active biomonitoring technique to collect particles, very useful in active volcanic areas characterized by continuous degassing and often not easily accessible to apply conventional sampling techniques. PMID:25311770

  12. 8. DETAIL OF PAGE ONE IN VOLUME ONE OF KREGEL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. DETAIL OF PAGE ONE IN VOLUME ONE OF KREGEL WINDMILL COMPANY LEDGERS RECORDING THE FOUNDING OF THE COMPANY ON 19 AUGUST 1879. - Kregel Windmill Company Factory, 1416 Central Avenue, Nebraska City, Otoe County, NE

  13. Book Holder And Page Turner For The Elderly And Handicapped

    NASA Technical Reports Server (NTRS)

    Kerley, James; Eklund, Wayne

    1993-01-01

    Device holds reading matter and facilitates page turning for person not having use of arms and hands. Accommodates variety of publication formats, whether book, magazine, or newspaper. Holder sits on hospital-bed table and adjusted to convenient viewing angle. Includes flat upright back support for reading matter, hinged base, and main bracket with bent-wire page holders. Top support on back extended for such large items as newspapers. Wings on back support extended for oversize materials. Reader turns page by gripping special rod via mouthpiece, applying friction cup at its tip to page, and manipulating rod. Mouthpiece wide and tapered so user grips with teeth and uses jaws to move it, rather than using tongue or lips. Helpful to older people, whose facial and mouth muscles weak.

  14. 1. Historic American Buildings Survey Annals of SF, Page 170 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Annals of SF, Page 170 Jocelyn Annin-Del Photo Taken: 1836 FOURTH OF JULY CELEBRATION YEAR BUILT 1836 - Jacob Leese House, Historic View, Grant Avenue, San Francisco, San Francisco County, CA

  15. Progress In Automatic Reading Of Complex Typeset Pages

    NASA Astrophysics Data System (ADS)

    Vincent, Philippe

    1989-07-01

    For a long time, automatic reading has been limited to optical character recognition. one year ago, except for one high end product, all industrial software or hardware products where limited to the reading of mono-column texts without images. This does not correspond to real life needs. In a current, company, pages which need to be transformed into electronic form are not only typewritten pages, but also complex pages from professional magazines, technical manuals, financial reports and tables, administrative documents, various directories, lists of spare parts etc... The real problem of automatic reading is to transform such complex paper pages including columns, images, drawings, titles, footnotes, legends, tables, occasionally in landscape format, into a computer text file without the help of an operator. Moreover, the problem is to perform this operation at an economical cost with limited computer resources in terms of processor and memory.

  16. 47 CFR 22.503 - Paging geographic area authorizations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... interference problems before bringing matters to the FCC. In the event that there is no co-channel paging... on a non-interfering basis. (j) Site location restriction. The transmitting antenna of each...

  17. Volcanic features of Io

    USGS Publications Warehouse

    Carr, M.H.; Masursky, H.; Strom, R.G.; Terrile, R.J.

    1979-01-01

    Volcanic activity is apparently higher on Io than on any other body in the Solar System. Its volcanic landforms can be compared with features on Earth to indicate the type of volcanism present on Io. ?? 1979 Nature Publishing Group.

  18. Structural features and complement-fixing activity of pectin from three Brassica oleracea varieties: white cabbage, kale, and red kale.

    PubMed

    Samuelsen, Anne Berit; Westereng, Bjørge; Yousif, Osman; Holtekjølen, Ann Katrin; Michaelsen, Terje E; Knutsen, Svein H

    2007-02-01

    Leaves of different cabbage species are used both as food and as wound healing remedies in traditional medicine. This supposed wound healing activity might be connected to presence of immunomodulating water soluble polysaccharides. To study this, three different cabbage varieties, white cabbage (W), kale (K), and red kale (RK), were pretreated with 80% ethanol and then extracted with water at 50 degrees C and 100 degrees C for isolation of polysaccharide-containing fractions. The fractions were analyzed for monosaccharide composition, glycosidic linkages, Mw distribution, protein content, and phenolic compounds and then tested for complement-fixing activity. All fractions contained pectin type polysaccharides with linkages corresponding to homogalacturonan and hairy regions. Those extracted at 50 degrees C contained higher amounts of neutral side chains and were more active in the complement-fixation test than those extracted at 100 degrees C. The fractions can be ranged by decreasing activity: K-50 > RK-50 > W-50 approximately = K-100 > RK100 approximately = W-100. Studies on structure-activity relationships (SAR) employing multivariate statistical analysis strongly suggest that the magnitude of the measured activity is influenced by the content of certain side chains in the polymers. High activity correlates to large neutral side chains with high amounts of (1-->6)- and (1-->3,6)-linked Gal and low amounts of (1-->4)-linked GalA but not on molecular weight distribution of the polymers.

  19. Where’s the Noise? Key Features of Spontaneous Activity and Neural Variability Arise through Learning in a Deterministic Network

    PubMed Central

    Hartmann, Christoph; Lazar, Andreea; Nessler, Bernhard; Triesch, Jochen

    2015-01-01

    Even in the absence of sensory stimulation the brain is spontaneously active. This background “noise” seems to be the dominant cause of the notoriously high trial-to-trial variability of neural recordings. Recent experimental observations have extended our knowledge of trial-to-trial variability and spontaneous activity in several directions: 1. Trial-to-trial variability systematically decreases following the onset of a sensory stimulus or the start of a motor act. 2. Spontaneous activity states in sensory cortex outline the region of evoked sensory responses. 3. Across development, spontaneous activity aligns itself with typical evoked activity patterns. 4. The spontaneous brain activity prior to the presentation of an ambiguous stimulus predicts how the stimulus will be interpreted. At present it is unclear how these observations relate to each other and how they arise in cortical circuits. Here we demonstrate that all of these phenomena can be accounted for by a deterministic self-organizing recurrent neural network model (SORN), which learns a predictive model of its sensory environment. The SORN comprises recurrently coupled populations of excitatory and inhibitory threshold units and learns via a combination of spike-timing dependent plasticity (STDP) and homeostatic plasticity mechanisms. Similar to balanced network architectures, units in the network show irregular activity and variable responses to inputs. Additionally, however, the SORN exhibits sequence learning abilities matching recent findings from visual cortex and the network’s spontaneous activity reproduces the experimental findings mentioned above. Intriguingly, the network’s behaviour is reminiscent of sampling-based probabilistic inference, suggesting that correlates of sampling-based inference can develop from the interaction of STDP and homeostasis in deterministic networks. We conclude that key observations on spontaneous brain activity and the variability of neural responses can be

  20. Where's the Noise? Key Features of Spontaneous Activity and Neural Variability Arise through Learning in a Deterministic Network.

    PubMed

    Hartmann, Christoph; Lazar, Andreea; Nessler, Bernhard; Triesch, Jochen

    2015-12-01

    Even in the absence of sensory stimulation the brain is spontaneously active. This background "noise" seems to be the dominant cause of the notoriously high trial-to-trial variability of neural recordings. Recent experimental observations have extended our knowledge of trial-to-trial variability and spontaneous activity in several directions: 1. Trial-to-trial variability systematically decreases following the onset of a sensory stimulus or the start of a motor act. 2. Spontaneous activity states in sensory cortex outline the region of evoked sensory responses. 3. Across development, spontaneous activity aligns itself with typical evoked activity patterns. 4. The spontaneous brain activity prior to the presentation of an ambiguous stimulus predicts how the stimulus will be interpreted. At present it is unclear how these observations relate to each other and how they arise in cortical circuits. Here we demonstrate that all of these phenomena can be accounted for by a deterministic self-organizing recurrent neural network model (SORN), which learns a predictive model of its sensory environment. The SORN comprises recurrently coupled populations of excitatory and inhibitory threshold units and learns via a combination of spike-timing dependent plasticity (STDP) and homeostatic plasticity mechanisms. Similar to balanced network architectures, units in the network show irregular activity and variable responses to inputs. Additionally, however, the SORN exhibits sequence learning abilities matching recent findings from visual cortex and the network's spontaneous activity reproduces the experimental findings mentioned above. Intriguingly, the network's behaviour is reminiscent of sampling-based probabilistic inference, suggesting that correlates of sampling-based inference can develop from the interaction of STDP and homeostasis in deterministic networks. We conclude that key observations on spontaneous brain activity and the variability of neural responses can be

  1. Where's the Noise? Key Features of Spontaneous Activity and Neural Variability Arise through Learning in a Deterministic Network.

    PubMed

    Hartmann, Christoph; Lazar, Andreea; Nessler, Bernhard; Triesch, Jochen

    2015-12-01

    Even in the absence of sensory stimulation the brain is spontaneously active. This background "noise" seems to be the dominant cause of the notoriously high trial-to-trial variability of neural recordings. Recent experimental observations have extended our knowledge of trial-to-trial variability and spontaneous activity in several directions: 1. Trial-to-trial variability systematically decreases following the onset of a sensory stimulus or the start of a motor act. 2. Spontaneous activity states in sensory cortex outline the region of evoked sensory responses. 3. Across development, spontaneous activity aligns itself with typical evoked activity patterns. 4. The spontaneous brain activity prior to the presentation of an ambiguous stimulus predicts how the stimulus will be interpreted. At present it is unclear how these observations relate to each other and how they arise in cortical circuits. Here we demonstrate that all of these phenomena can be accounted for by a deterministic self-organizing recurrent neural network model (SORN), which learns a predictive model of its sensory environment. The SORN comprises recurrently coupled populations of excitatory and inhibitory threshold units and learns via a combination of spike-timing dependent plasticity (STDP) and homeostatic plasticity mechanisms. Similar to balanced network architectures, units in the network show irregular activity and variable responses to inputs. Additionally, however, the SORN exhibits sequence learning abilities matching recent findings from visual cortex and the network's spontaneous activity reproduces the experimental findings mentioned above. Intriguingly, the network's behaviour is reminiscent of sampling-based probabilistic inference, suggesting that correlates of sampling-based inference can develop from the interaction of STDP and homeostasis in deterministic networks. We conclude that key observations on spontaneous brain activity and the variability of neural responses can be

  2. Visualizing Worlds from Words on a Page

    ERIC Educational Resources Information Center

    Parsons, Linda T.

    2006-01-01

    This study involved fourth grade children as co-researchers of their engaged, aesthetic reading experience. As members of the "Readers as Researchers Club," they documented their engagement with text--how they create, enter, and sustain the story world. The children, who self-identified as avid readers, explored the activities central to their…

  3. ASM Based Synthesis of Handwritten Arabic Text Pages

    PubMed Central

    Dinges, Laslo; Al-Hamadi, Ayoub; Elzobi, Moftah; El-etriby, Sherif; Ghoneim, Ahmed

    2015-01-01

    Document analysis tasks, as text recognition, word spotting, or segmentation, are highly dependent on comprehensive and suitable databases for training and validation. However their generation is expensive in sense of labor and time. As a matter of fact, there is a lack of such databases, which complicates research and development. This is especially true for the case of Arabic handwriting recognition, that involves different preprocessing, segmentation, and recognition methods, which have individual demands on samples and ground truth. To bypass this problem, we present an efficient system that automatically turns Arabic Unicode text into synthetic images of handwritten documents and detailed ground truth. Active Shape Models (ASMs) based on 28046 online samples were used for character synthesis and statistical properties were extracted from the IESK-arDB database to simulate baselines and word slant or skew. In the synthesis step ASM based representations are composed to words and text pages, smoothed by B-Spline interpolation and rendered considering writing speed and pen characteristics. Finally, we use the synthetic data to validate a segmentation method. An experimental comparison with the IESK-arDB database encourages to train and test document analysis related methods on synthetic samples, whenever no sufficient natural ground truthed data is available. PMID:26295059

  4. ASM Based Synthesis of Handwritten Arabic Text Pages.

    PubMed

    Dinges, Laslo; Al-Hamadi, Ayoub; Elzobi, Moftah; El-Etriby, Sherif; Ghoneim, Ahmed

    2015-01-01

    Document analysis tasks, as text recognition, word spotting, or segmentation, are highly dependent on comprehensive and suitable databases for training and validation. However their generation is expensive in sense of labor and time. As a matter of fact, there is a lack of such databases, which complicates research and development. This is especially true for the case of Arabic handwriting recognition, that involves different preprocessing, segmentation, and recognition methods, which have individual demands on samples and ground truth. To bypass this problem, we present an efficient system that automatically turns Arabic Unicode text into synthetic images of handwritten documents and detailed ground truth. Active Shape Models (ASMs) based on 28046 online samples were used for character synthesis and statistical properties were extracted from the IESK-arDB database to simulate baselines and word slant or skew. In the synthesis step ASM based representations are composed to words and text pages, smoothed by B-Spline interpolation and rendered considering writing speed and pen characteristics. Finally, we use the synthetic data to validate a segmentation method. An experimental comparison with the IESK-arDB database encourages to train and test document analysis related methods on synthetic samples, whenever no sufficient natural ground truthed data is available. PMID:26295059

  5. [Features of the lipid peroxidation process and antioxidant activity of white rats in extreme, multi-stage supercooling].

    PubMed

    Serebrennikova, E G; Mamaev, A T; Akhmedov, I G

    1992-01-01

    High content of polyenic fatty acids, slight increase in antioxidative activity and decrease in content of malonic dialdehyde (MDA) in rat myocardial tissues were observed in supercooling. The data obtained suggest that intensive oxidation of fatty acids occurred in the tissues, which may be essential for synthesis of biologically active substances involved in development of resistance to supercooling. Multiple supercooling caused an opposite effect in lung tissue: saturation of lipids was increased, antioxidative activity was maintained on the level similar to the control values, while content of MDA was markedly increased apparently due to destruction of metabolic products penetrating from other tissues. The dissimilar impairments of lipid metabolism were detected in liver tissue, where multiple supercooling did not alter the rate of lipid saturation, antioxidative activity was unaltered and content of MDA was as low as in the control animals.

  6. Using Shadow Page Cache to Improve Isolated Drivers Performance

    PubMed Central

    Dong, Xiaoshe; Wang, Endong; Chen, Baoke; Zhu, Zhengdong; Liu, Chengzhe

    2015-01-01

    With the advantage of the reusability property of the virtualization technology, users can reuse various types and versions of existing operating systems and drivers in a virtual machine, so as to customize their application environment. In order to prevent users' virtualization environments being impacted by driver faults in virtual machine, Chariot examines the correctness of driver's write operations by the method of combining a driver's write operation capture and a driver's private access control table. However, this method needs to keep the write permission of shadow page table as read-only, so as to capture isolated driver's write operations through page faults, which adversely affect the performance of the driver. Based on delaying setting frequently used shadow pages' write permissions to read-only, this paper proposes an algorithm using shadow page cache to improve the performance of isolated drivers and carefully study the relationship between the performance of drivers and the size of shadow page cache. Experimental results show that, through the shadow page cache, the performance of isolated drivers can be greatly improved without impacting Chariot's reliability too much. PMID:25815373

  7. Using shadow page cache to improve isolated drivers performance.

    PubMed

    Zheng, Hao; Dong, Xiaoshe; Wang, Endong; Chen, Baoke; Zhu, Zhengdong; Liu, Chengzhe

    2015-01-01

    With the advantage of the reusability property of the virtualization technology, users can reuse various types and versions of existing operating systems and drivers in a virtual machine, so as to customize their application environment. In order to prevent users' virtualization environments being impacted by driver faults in virtual machine, Chariot examines the correctness of driver's write operations by the method of combining a driver's write operation capture and a driver's private access control table. However, this method needs to keep the write permission of shadow page table as read-only, so as to capture isolated driver's write operations through page faults, which adversely affect the performance of the driver. Based on delaying setting frequently used shadow pages' write permissions to read-only, this paper proposes an algorithm using shadow page cache to improve the performance of isolated drivers and carefully study the relationship between the performance of drivers and the size of shadow page cache. Experimental results show that, through the shadow page cache, the performance of isolated drivers can be greatly improved without impacting Chariot's reliability too much. PMID:25815373

  8. Prostate-associated gene 4 (PAGE4), an intrinsically disordered cancer/testis antigen, is a novel therapeutic target for prostate cancer

    PubMed Central

    Kulkarni, Prakash; Dunker, A Keith; Weninger, Keith; Orban, John

    2016-01-01

    Prostate-associated gene 4 (PAGE4) is a remarkably prostate-specific Cancer/Testis Antigen that is highly upregulated in the human fetal prostate and its diseased states but not in the adult normal gland. PAGE4 is an intrinsically disordered protein (IDP) that functions as a stress-response protein to suppress reactive oxygen species as well as prevent DNA damage. In addition, PAGE4 is also a transcriptional regulator that potentiates transactivation by the oncogene c-Jun. c-Jun forms the AP-1 complex by heterodimerizing with members of the Fos family and plays an important role in the development and pathology of the prostate gland, underscoring the importance of the PAGE4/c-Jun interaction. HIPK1, also a component of the stress-response pathway, phosphorylates PAGE4 at T51 which is critical for its transcriptional activity. Phosphorylation induces conformational and dynamic switching in the PAGE4 ensemble leading to a new cellular function. Finally, bioinformatics evidence suggests that the PAGE4 mRNA could be alternatively spliced resulting in four potential isoforms of the polypeptide alluding to the possibility of a range of conformational ensembles with latent functions. Considered together, the data suggest that PAGE4 may represent the first molecular link between stress and prostate cancer (PCa). Thus, pharmacologically targeting PAGE4 may be a novel opportunity for treating and managing patients with PCa, especially patients with low-risk disease. PMID:27270343

  9. The relationship between the lizard eye and associated bony features: a cautionary note for interpreting fossil activity patterns.

    PubMed

    Hall, Margaret I

    2009-06-01

    Activity pattern, the time of day when an animal is active, is associated with ecology. There are two major activity patterns: diurnal (awake during the day in a photopic environment) and nocturnal (awake at night in a scotopic environment). Lizards exhibit characteristic eye shapes associated with activity pattern, with scotopic-adapted lizard eyes optimized for visual sensitivity with large corneal diameters relative to their eye axial lengths, and photopic-adapted lizards optimized for visual acuity, with larger axial lengths of the eye relative to their corneal diameters. This study: (1) quantifies the relationship between the lizard eye and its associated bony anatomy (the orbit, sclerotic ring, and associated skull widths); (2) investigates how activity pattern is reflected in that bony anatomy; and (3) determines if it is possible to reliably interpret activity pattern for a lizard that does not have the soft tissue available for study, specifically, for a fossil. Knowledge of extinct lizards' activity patterns would be useful in making paleoecological interpretations. Here, 96 scotopic- and photopic-adapted lizard species are analyzed in a phylogenetic context. Although there is a close relationship between the lepidosaur eye and associated bony anatomy, based on these data activity pattern cannot be reliably interpreted for bony-only specimens, such as a fossil, possibly because of the limited ossification of the lepidosaur skull. Caution should be exercised when utilizing lizard bony anatomy to interpret light-level adaptation, either for a fossil lizard or as part of an extant phylogenetic bracket to interpret other extinct animals with sclerotic rings, such as dinosaurs. PMID:19462447

  10. Detection of the end point temperature of thermal denatured protein in fish and chicken meat through SDS-PAGE electrophoresis

    NASA Astrophysics Data System (ADS)

    Gao, Hongwei; Mao, Mao; Liang, Chengzhu; Lin, Chao; Xiang, Jianhai

    2009-03-01

    Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) was applied in the detection of the end point temperature (EPT) of thermal denatured protein in fish and meat in this study. It was also used in studying the thermal denatured temperature range of proteins in salmon and chicken meat. The results show that the temperature ranges of denatured proteins were from 65°C to 75°C, and these temperature ranges were influenced by the processing methods. Through SDS-PAGE, the features of repeated heating thermal denatured proteins under the same temperature and processing time were studied. The electrophoresis patterns of thermal denatured proteins determined through repeated heating at the same temperature did not exhibit any change. For the detection of cooked fish and meat samples, they were subjected to applying the SDS-PAGE method, which revealed an EPT ranging from 60°C to 80°C.

  11. Interactive effect of salicylic acid on some physiological features and antioxidant enzymes activity in ginger (Zingiber officinale Roscoe).

    PubMed

    Ghasemzadeh, Ali; Jaafar, Hawa Z E

    2013-01-01

    The effect of foliar salicylic acid (SA) applications (10⁻³ and 10⁻⁵ M) on activities of nitrate reductase, guaiacol peroxidase (POD), superoxide dismutases (SOD), catalase (CAT) and proline enzymes and physiological parameters was evaluated in two ginger varieties (Halia Bentong and Halia Bara) under greenhouse conditions. In both varieties, tested treatments generally enhanced photosynthetic rate and total dry weight. Photosynthetic rate increases were generally accompanied by increased or unchanged stomatal conductance levels, although intercellular CO₂ concentrations of treated plants were typically lower than in controls. Lower SA concentrations were generally more effective in enhancing photosynthetic rate and plant growth. Exogenous application of SA increased antioxidant enzyme activities and proline content; the greatest responses were obtained in plants sprayed with 10⁻⁵ M SA, with significant increases observed in CAT (20.1%), POD (45.2%), SOD (44.1%) and proline (43.1%) activities. Increased CAT activity in leaves is naturally expected to increase photosynthetic efficiency and thus net photosynthesis by maintaining a constant CO₂ supply. Our results support the idea that low SA concentrations (10⁻⁵ M) may induce nitrite reductase synthesis by mobilizing intracellular NO³⁻ and can provide protection to nitrite reductase degradation in vivo in the absence of NO³⁻. Observed positive correlations among proline, SOD, CAT and POD activities in the studied varieties suggest that increased SOD activity was accompanied by increases in CAT and POD activities because of the high demands of H₂O₂ quenching. PMID:23698049

  12. Geographic Information Systems and Web Page Development

    NASA Technical Reports Server (NTRS)

    Reynolds, Justin

    2004-01-01

    The Facilities Engineering and Architectural Branch is responsible for the design and maintenance of buildings, laboratories, and civil structures. In order to improve efficiency and quality, the FEAB has dedicated itself to establishing a data infrastructure based on Geographic Information Systems, GIS. The value of GIS was explained in an article dating back to 1980 entitled "Need for a Multipurpose Cadastre" which stated, "There is a critical need for a better land-information system in the United States to improve land-conveyance procedures, furnish a basis for equitable taxation, and provide much-needed information for resource management and environmental planning." Scientists and engineers both point to GIS as the solution. What is GIS? According to most text books, Geographic Information Systems is a class of software that stores, manages, and analyzes mapable features on, above, or below the surface of the earth. GIS software is basically database management software to the management of spatial data and information. Simply put, Geographic Information Systems manage, analyze, chart, graph, and map spatial information. GIS can be broken down into two main categories, urban GIS and natural resource GIS. Further still, natural resource GIS can be broken down into six sub-categories, agriculture, forestry, wildlife, catchment management, archaeology, and geology/mining. Agriculture GIS has several applications, such as agricultural capability analysis, land conservation, market analysis, or whole farming planning. Forestry GIs can be used for timber assessment and management, harvest scheduling and planning, environmental impact assessment, and pest management. GIS when used in wildlife applications enables the user to assess and manage habitats, identify and track endangered and rare species, and monitor impact assessment.

  13. Featured Article: Differential regulation of endothelial nitric oxide synthase phosphorylation by protease-activated receptors in adult human endothelial cells

    PubMed Central

    Tillery, Lakeisha C; Epperson, Tenille A; Eguchi, Satoru

    2016-01-01

    Protease-activated receptors have been shown to regulate endothelial nitric oxide synthase through the phosphorylation of specific sites on the enzyme. It has been established that PAR-2 activation phosphorylates eNOS-Ser-1177 and leads to the production of the potent vasodilator nitric oxide, while PAR-1 activation phosphorylates eNOS-Thr-495 and decreases nitric oxide production in human umbilical vein endothelial cells. In this study, we hypothesize a differential coupling of protease-activated receptors to the signaling pathways that regulates endothelial nitric oxide synthase and nitric oxide production in primary adult human coronary artery endothelial cells. Using Western Blot analysis, we showed that thrombin and the PAR-1 activating peptide, TFLLR, lead to the phosphorylation of eNOS-Ser-1177 in human coronary artery endothelial cells, which was blocked by SCH-79797 (SCH), a PAR-1 inhibitor. Using the nitrate/nitrite assay, we also demonstrated that the thrombin- and TFLLR-induced production of nitric oxide was inhibited by SCH and L-NAME, a NOS inhibitor. In addition, we observed that TFLLR, unlike thrombin, significantly phosphorylated eNOS-Thr-495, which may explain the observed delay in nitric oxide production in comparison to that of thrombin. Activation of PAR-2 by SLIGRL, a PAR-2 specific ligand, leads to dual phosphorylation of both catalytic sites but primarily regulated eNOS-Thr-495 phosphorylation with no change in nitric oxide production in human coronary artery endothelial cells. PAR-3, known as the non-signaling receptor, was activated by TFRGAP, a PAR-3 mimicking peptide, and significantly induced the phosphorylation of eNOS-Thr-495 with minimal phosphorylation of eNOS-Ser-1177 with no change in nitric oxide production. In addition, we confirmed that PAR-mediated eNOS-Ser-1177 phosphorylation was Ca2+-dependent using the Ca2+ chelator, BAPTA, while eNOS-Thr-495 phosphorylation was mediated via Rho kinase using the ROCK inhibitor, Y-27632

  14. Featured Article: Differential regulation of endothelial nitric oxide synthase phosphorylation by protease-activated receptors in adult human endothelial cells.

    PubMed

    Tillery, Lakeisha C; Epperson, Tenille A; Eguchi, Satoru; Motley, Evangeline D

    2016-03-01

    Protease-activated receptors have been shown to regulate endothelial nitric oxide synthase through the phosphorylation of specific sites on the enzyme. It has been established that PAR-2 activation phosphorylates eNOS-Ser-1177 and leads to the production of the potent vasodilator nitric oxide, while PAR-1 activation phosphorylates eNOS-Thr-495 and decreases nitric oxide production in human umbilical vein endothelial cells. In this study, we hypothesize a differential coupling of protease-activated receptors to the signaling pathways that regulates endothelial nitric oxide synthase and nitric oxide production in primary adult human coronary artery endothelial cells. Using Western Blot analysis, we showed that thrombin and the PAR-1 activating peptide, TFLLR, lead to the phosphorylation of eNOS-Ser-1177 in human coronary artery endothelial cells, which was blocked by SCH-79797 (SCH), a PAR-1 inhibitor. Using the nitrate/nitrite assay, we also demonstrated that the thrombin- and TFLLR-induced production of nitric oxide was inhibited by SCH and L-NAME, a NOS inhibitor. In addition, we observed that TFLLR, unlike thrombin, significantly phosphorylated eNOS-Thr-495, which may explain the observed delay in nitric oxide production in comparison to that of thrombin. Activation of PAR-2 by SLIGRL, a PAR-2 specific ligand, leads to dual phosphorylation of both catalytic sites but primarily regulated eNOS-Thr-495 phosphorylation with no change in nitric oxide production in human coronary artery endothelial cells. PAR-3, known as the non-signaling receptor, was activated by TFRGAP, a PAR-3 mimicking peptide, and significantly induced the phosphorylation of eNOS-Thr-495 with minimal phosphorylation of eNOS-Ser-1177 with no change in nitric oxide production. In addition, we confirmed that PAR-mediated eNOS-Ser-1177 phosphorylation was Ca(2+)-dependent using the Ca(2+) chelator, BAPTA, while eNOS-Thr-495 phosphorylation was mediated via Rho kinase using the ROCK inhibitor, Y-27632

  15. Deciphering solar magnetic activity. I. On the relationship between the sunspot cycle and the evolution of small magnetic features

    SciTech Connect

    McIntosh, Scott W.; Wang, Xin; Markel, Robert S.; Thompson, Michael J.; Leamon, Robert J.; Malanushenko, Anna V.; Davey, Alisdair R.; Howe, Rachel; Krista, Larisza D.; Cirtain, Jonathan W.; Gurman, Joseph B.; Pesnell, William D.

    2014-09-01

    Sunspots are a canonical marker of the Sun's internal magnetic field which flips polarity every ∼22 yr. The principal variation of sunspots, an ∼11 yr variation, modulates the amount of the magnetic field that pierces the solar surface and drives significant variations in our star's radiative, particulate, and eruptive output over that period. This paper presents observations from the Solar and Heliospheric Observatory and Solar Dynamics Observatory indicating that the 11 yr sunspot variation is intrinsically tied to the spatio-temporal overlap of the activity bands belonging to the 22 yr magnetic activity cycle. Using a systematic analysis of ubiquitous coronal brightpoints and the magnetic scale on which they appear to form, we show that the landmarks of sunspot cycle 23 can be explained by considering the evolution and interaction of the overlapping activity bands of the longer-scale variability.

  16. Quantitatively analyzing metathesis catalyst activity and structural features in silica-supported tungsten imido-alkylidene complexes.

    PubMed

    Mougel, Victor; Santiago, Celine B; Zhizhko, Pavel A; Bess, Elizabeth N; Varga, Jeno; Frater, Georg; Sigman, Matthew S; Copéret, Christophe

    2015-05-27

    A broad series of fully characterized, well-defined silica-supported W metathesis catalysts with the general formula [(≡SiO)W(═NAr)(═CHCMe2R)(X)] (Ar = 2,6-iPr2C6H3 (AriPr), 2,6-Cl2C6H3 (ArCl), 2-CF3C6H4 (ArCF3), and C6F5 (ArF5); X = OC(CF3)3 (OtBuF9), OCMe(CF3)2 (OtBuF6), OtBu, OSi(OtBu)3, 2,5-dimethylpyrrolyl (Me2Pyr) and R = Me or Ph) was prepared by grafting bis-X substituted complexes [W(NAr)(═CHCMe2R)(X)2] on silica partially dehydroxylated at 700 °C (SiO2-(700)), and their activity was evaluated with the goal to obtain detailed structure-activity relationships. Quantitative influence of the ligand set on the activity (turnover frequency, TOF) in self-metathesis of cis-4-nonene was investigated using multivariate linear regression analysis tools. The TOF of these catalysts (activity) can be well predicted from simple steric and electronic parameters of the parent protonated ligands; it is described by the mutual contribution of the NBO charge of the nitrogen or the IR intensity of the symmetric N-H stretch of the ArNH2, corresponding to the imido ligand, together with the Sterimol B5 and pKa of HX, representing the X ligand. This quantitative and predictive structure-activity relationship analysis of well-defined heterogeneous catalysts shows that high activity is associated with the combination of X and NAr ligands of opposite electronic character and paves the way toward rational development of metathesis catalysts.

  17. A tale of two itches. Common features and notable differences in brain activation evoked by cowhage and histamine induced itch.

    PubMed

    Papoiu, Alexandru D P; Coghill, Robert C; Kraft, Robert A; Wang, Hui; Yosipovitch, Gil

    2012-02-15

    Previous PET and fMRI brain imaging studies targeting neural networks processing itch sensation have used histamine as the sole itch inducer. In contrast with histamine, cowhage-induced itch is mediated via proteinase activated receptors PAR2 and is transmitted through a separate spinothalamic pathway, therefore imaging the brain activation evoked by cowhage could provide further insight into central processing of itch. We report for the first time a functional MRI Arterial Spin Labeling (ASL) study of neuronal processing of itch induced by cowhage, analyzed in contrast with histamine-induced itch. We also explored the brain responses induced by histamine and cowhage combined in a tight sequence. The results of our analyses obtained in a group of 15 healthy volunteers suggested that cowhage and histamine co-activated a core group of brain structures, while also revealing notable differences. Core areas activated by both stimuli were found in the thalamus, primary and secondary somatosensory cortices, posterior parietal cortex, superior and middle temporal cortices, PCC, ACC, precuneus and cuneus. Cowhage induced a notably distinct and more extensive involvement of the insular cortex, claustrum, basal ganglia, putamen, thalamic nuclei and pulvinar. The differences observed between these two itch modalities were investigated to determine the impact of quantitative versus qualitative factors, and correlations between itch intensity and the patterns in brain activation were explored. Our analysis revealed that the most significant differences between cowhage and histamine itch were not affected by stimulus intensity, although a subset of regions displayed activations which were intensity-dependent. The combined application of cowhage and histamine highlighted the role of insula and claustrum in the processing of both itch modalities in the same time. The present results suggest the existence of overlapping but also distinct neuronal networks processing these two

  18. Application of genetic algorithm-kernel partial least square as a novel nonlinear feature selection method: activity of carbonic anhydrase II inhibitors.

    PubMed

    Jalali-Heravi, Mehdi; Kyani, Anahita

    2007-05-01

    This paper introduces the genetic algorithm-kernel partial least square (GA-KPLS), as a novel nonlinear feature selection method. This technique combines genetic algorithms (GAs) as powerful optimization methods with KPLS as a robust nonlinear statistical method for variable selection. This feature selection method is combined with artificial neural network to develop a nonlinear QSAR model for predicting activities of a series of substituted aromatic sulfonamides as carbonic anhydrase II (CA II) inhibitors. Eight simple one- and two-dimensional descriptors were selected by GA-KPLS and considered as inputs for developing artificial neural networks (ANNs). These parameters represent the role of acceptor-donor pair, hydrogen bonding, hydrosolubility and lipophilicity of the active sites and also the size of the inhibitors on inhibitor-isozyme interaction. The accuracy of 8-4-1 networks was illustrated by validation techniques of leave-one-out (LOO) and leave-multiple-out (LMO) cross-validations and Y-randomization. Superiority of this method (GA-KPLS-ANN) over the linear one (MLR) in a previous work and also the GA-PLS-ANN in which a linear feature selection method has been used indicates that the GA-KPLS approach is a powerful method for the variable selection in nonlinear systems. PMID:17316919

  19. Geographic Information Systems and Web Page Development

    NASA Technical Reports Server (NTRS)

    Reynolds, Justin

    2004-01-01

    The Facilities Engineering and Architectural Branch is responsible for the design and maintenance of buildings, laboratories, and civil structures. In order to improve efficiency and quality, the FEAB has dedicated itself to establishing a data infrastructure based on Geographic Information Systems, GIs. The value of GIS was explained in an article dating back to 1980 entitled "Need for a Multipurpose Cadastre which stated, "There is a critical need for a better land-information system in the United States to improve land-conveyance procedures, furnish a basis for equitable taxation, and provide much-needed information for resource management and environmental planning." Scientists and engineers both point to GIS as the solution. What is GIS? According to most text books, Geographic Information Systems is a class of software that stores, manages, and analyzes mapable features on, above, or below the surface of the earth. GIS software is basically database management software to the management of spatial data and information. Simply put, Geographic Information Systems manage, analyze, chart, graph, and map spatial information. At the outset, I was given goals and expectations from my branch and from my mentor with regards to the further implementation of GIs. Those goals are as follows: (1) Continue the development of GIS for the underground structures. (2) Extract and export annotated data from AutoCAD drawing files and construct a database (to serve as a prototype for future work). (3) Examine existing underground record drawings to determine existing and non-existing underground tanks. Once this data was collected and analyzed, I set out on the task of creating a user-friendly database that could be assessed by all members of the branch. It was important that the database be built using programs that most employees already possess, ruling out most AutoCAD-based viewers. Therefore, I set out to create an Access database that translated onto the web using Internet

  20. The impact of salient advertisements on reading and attention on web pages.

    PubMed

    Simola, Jaana; Kuisma, Jarmo; Oörni, Anssi; Uusitalo, Liisa; Hyönä, Jukka

    2011-06-01

    Human vision is sensitive to salient features such as motion. Therefore, animation and onset of advertisements on Websites may attract visual attention and disrupt reading. We conducted three eye tracking experiments with authentic Web pages to assess whether (a) ads are efficiently ignored, (b) ads attract overt visual attention and disrupt reading, or (c) ads are covertly attended with distraction showing up indirectly in the reading performance. The Web pages contained an ad above a central text and another ad to the right of the text. In Experiments 1, 2, and 3A the task was to read for comprehension. Experiment 1 examined whether the degree of animation affects attention toward the ads. The results showed that ads were overtly attended during reading and that the dwell times on ads were the longest when the ad above was static and the other ad was animated. In Experiments 2 and 3, the ads appeared abruptly after a random time interval. The results showed that attention (i.e., the time when the eyes first entered an ad) was related to the ad onset time. This happened especially for the ad to the right, indicating that ads appearing close to the text region capture overt attention. In Experiment 3B the participants browsed the Web pages according to their own interest. The study demonstrated that salient ads attract overt visual attention and disrupt reading, but during free browsing, ads were viewed more frequently and for longer time than during reading. PMID:21604909

  1. The Candida Genome Database: the new homology information page highlights protein similarity and phylogeny.

    PubMed

    Binkley, Jonathan; Arnaud, Martha B; Inglis, Diane O; Skrzypek, Marek S; Shah, Prachi; Wymore, Farrell; Binkley, Gail; Miyasato, Stuart R; Simison, Matt; Sherlock, Gavin

    2014-01-01

    The Candida Genome Database (CGD, http://www.candidagenome.org/) is a freely available online resource that provides gene, protein and sequence information for multiple Candida species, along with web-based tools for accessing, analyzing and exploring these data. The goal of CGD is to facilitate and accelerate research into Candida pathogenesis and biology. The CGD Web site is organized around Locus pages, which display information collected about individual genes. Locus pages have multiple tabs for accessing different types of information; the default Summary tab provides an overview of the gene name, aliases, phenotype and Gene Ontology curation, whereas other tabs display more in-depth information, including protein product details for coding genes, notes on changes to the sequence or structure of the gene and a comprehensive reference list. Here, in this update to previous NAR Database articles featuring CGD, we describe a new tab that we have added to the Locus page, entitled the Homology Information tab, which displays phylogeny and gene similarity information for each locus.

  2. Molecular pathway activation features linked with transition from normal skin to primary and metastatic melanomas in human.

    PubMed

    Shepelin, Denis; Korzinkin, Mikhail; Vanyushina, Anna; Aliper, Alexander; Borisov, Nicolas; Vasilov, Raif; Zhukov, Nikolay; Sokov, Dmitry; Prassolov, Vladimir; Gaifullin, Nurshat; Zhavoronkov, Alex; Bhullar, Bhupinder; Buzdin, Anton

    2016-01-01

    Melanoma is the most aggressive and dangerous type of skin cancer, but its molecular mechanisms remain largely unclear. For transcriptomic data of 478 primary and metastatic melanoma, nevi and normal skin samples, we performed high-throughput analysis of intracellular molecular networks including 592 signaling and metabolic pathways. We showed that at the molecular pathway level, the formation of nevi largely resembles transition from normal skin to primary melanoma. Using a combination of bioinformatic machine learning algorithms, we identified 44 characteristic signaling and metabolic pathways connected with the formation of nevi, development of primary melanoma, and its metastases. We created a model describing formation and progression of melanoma at the level of molecular pathway activation. We discovered six novel associations between activation of metabolic molecular pathways and progression of melanoma: for allopregnanolone biosynthesis, L-carnitine biosynthesis, zymosterol biosynthesis (inhibited in melanoma), fructose 2, 6-bisphosphate synthesis and dephosphorylation, resolvin D biosynthesis (activated in melanoma), D-myo-inositol hexakisphosphate biosynthesis (activated in primary, inhibited in metastatic melanoma). Finally, we discovered fourteen tightly coordinated functional clusters of molecular pathways. This study helps to decode molecular mechanisms underlying the development of melanoma. PMID:26624979

  3. Molecular pathway activation features linked with transition from normal skin to primary and metastatic melanomas in human

    PubMed Central

    Shepelin, Denis; Korzinkin, Mikhail; Vanyushina, Anna; Aliper, Alexander; Borisov, Nicolas; Vasilov, Raif; Zhukov, Nikolay; Sokov, Dmitry; Prassolov, Vladimir; Gaifullin, Nurshat; Zhavoronkov, Alex; Bhullar, Bhupinder; Buzdin, Anton

    2016-01-01

    Melanoma is the most aggressive and dangerous type of skin cancer, but its molecular mechanisms remain largely unclear. For transcriptomic data of 478 primary and metastatic melanoma, nevi and normal skin samples, we performed high-throughput analysis of intracellular molecular networks including 592 signaling and metabolic pathways. We showed that at the molecular pathway level, the formation of nevi largely resembles transition from normal skin to primary melanoma. Using a combination of bioinformatic machine learning algorithms, we identified 44 characteristic signaling and metabolic pathways connected with the formation of nevi, development of primary melanoma, and its metastases. We created a model describing formation and progression of melanoma at the level of molecular pathway activation. We discovered six novel associations between activation of metabolic molecular pathways and progression of melanoma: for allopregnanolone biosynthesis, L-carnitine biosynthesis, zymosterol biosynthesis (inhibited in melanoma), fructose 2, 6-bisphosphate synthesis and dephosphorylation, resolvin D biosynthesis (activated in melanoma), D-myo-inositol hexakisphosphate biosynthesis (activated in primary, inhibited in metastatic melanoma). Finally, we discovered fourteen tightly coordinated functional clusters of molecular pathways. This study helps to decode molecular mechanisms underlying the development of melanoma. PMID:26624979

  4. Molecular pathway activation features linked with transition from normal skin to primary and metastatic melanomas in human.

    PubMed

    Shepelin, Denis; Korzinkin, Mikhail; Vanyushina, Anna; Aliper, Alexander; Borisov, Nicolas; Vasilov, Raif; Zhukov, Nikolay; Sokov, Dmitry; Prassolov, Vladimir; Gaifullin, Nurshat; Zhavoronkov, Alex; Bhullar, Bhupinder; Buzdin, Anton

    2016-01-01

    Melanoma is the most aggressive and dangerous type of skin cancer, but its molecular mechanisms remain largely unclear. For transcriptomic data of 478 primary and metastatic melanoma, nevi and normal skin samples, we performed high-throughput analysis of intracellular molecular networks including 592 signaling and metabolic pathways. We showed that at the molecular pathway level, the formation of nevi largely resembles transition from normal skin to primary melanoma. Using a combination of bioinformatic machine learning algorithms, we identified 44 characteristic signaling and metabolic pathways connected with the formation of nevi, development of primary melanoma, and its metastases. We created a model describing formation and progression of melanoma at the level of molecular pathway activation. We discovered six novel associations between activation of metabolic molecular pathways and progression of melanoma: for allopregnanolone biosynthesis, L-carnitine biosynthesis, zymosterol biosynthesis (inhibited in melanoma), fructose 2, 6-bisphosphate synthesis and dephosphorylation, resolvin D biosynthesis (activated in melanoma), D-myo-inositol hexakisphosphate biosynthesis (activated in primary, inhibited in metastatic melanoma). Finally, we discovered fourteen tightly coordinated functional clusters of molecular pathways. This study helps to decode molecular mechanisms underlying the development of melanoma.

  5. 78 FR 51265 - 30-Day Notice of Proposed Information Collection: Application for Additional Visa Pages or...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-20

    ... Notice of Proposed Information Collection: Application for Additional Visa Pages or Miscellaneous...: Title of Information Collection: Application for Additional Visa Pages or Miscellaneous Passport... applies for the addition of visa pages to that passport, the Department must confirm the...

  6. Does the Op-Ed Page Have a Chance to Become a Public Forum?

    ERIC Educational Resources Information Center

    Ciofalo, Andrew; Traverso, Kim

    1994-01-01

    Surveys op-ed page editors, finding that fewer than half of the responding papers have op-ed pages; that professional journalists, public figures, and propagandists dominate the pages; and that editors firmly control the agenda. (SR)

  7. Natural killer cell dysfunction is a distinguishing feature of systemic onset juvenile rheumatoid arthritis and macrophage activation syndrome.

    PubMed

    Villanueva, Joyce; Lee, Susan; Giannini, Edward H; Graham, Thomas B; Passo, Murray H; Filipovich, Alexandra; Grom, Alexei A

    2005-01-01

    Macrophage activation syndrome (MAS) has been reported in association with many rheumatic diseases, most commonly in systemic juvenile rheumatoid arthritis (sJRA). Clinically, MAS is similar to hemophagocytic lymphohistiocytosis (HLH), a genetic disorder with absent or depressed natural killer (NK) function. We have previously reported that, as in HLH, patients with MAS have profoundly decreased NK activity, suggesting that this abnormality might be relevant to the pathogenesis of the syndrome. Here we examined the extent of NK dysfunction across the spectrum of diseases that comprise juvenile rheumatoid arthritis (JRA). Peripheral blood mononuclear cells (PBMC) were collected from patients with pauciarticular (n = 4), polyarticular (n = 16), and systemic (n = 20) forms of JRA. NK cytolytic activity was measured after co-incubation of PBMC with the NK-sensitive K562 cell line. NK cells (CD56+/T cell receptor [TCR]-alphabeta-), NK T cells (CD56+/TCR-alphabeta+), and CD8+ T cells were also assessed for perforin and granzyme B expression by flow cytometry. Overall, NK cytolytic activity was significantly lower in patients with sJRA than in other JRA patients and controls. In a subgroup of patients with predominantly sJRA, NK cell activity was profoundly decreased: in 10 of 20 patients with sJRA and in only 1 of 20 patients with other JRA, levels of NK activity were below two standard deviations of pediatric controls (P = 0.002). Some decrease in perforin expression in NK cells and cytotoxic T lymphocytes was seen in patients within each of the JRA groups with no statistically significant differences. There was a profound decrease in the proportion of circulating CD56bright NK cells in three sJRA patients, a pattern similar to that previously observed in MAS and HLH. In conclusion, a subgroup of patients with JRA who have not yet had an episode of MAS showed decreased NK function and an absence of circulating CD56bright population, similar to the abnormalities observed

  8. Statistical properties of sunspot, active region distributions and flare occurrences in the cycle 23 as detected from the Solar Feature Catalogues

    NASA Astrophysics Data System (ADS)

    Zharkova, V. V.; Zharkov, S. I.

    2006-08-01

    The statistical properties of sunspot and active regions (plages) distributions and their relation to flare distributions are presented for 1996-2005 from the automated Solar Feature Catalogues from the SOHO and Meudon Observatories (SFC, http://solar.inf.brad.ac.uk). Cross-correlation analysis is carried out between flare sizes, locations, significance and active region/sunspot parameters including magnetic field extracted in SFC. Sunspot and plage area distributions reveals a strong North-South asymmetry of about 0.2 and the period of about 7-8 years for sunspots and of 0.5 and period of 9 years for plages with both asymmetries decreasing towards the next cycle minimum. The temporal distribution of solar flare occurrences in Northern and Southern hemispheres, at different latitudes and longitudes are compared with those of plage and sunspot areas and LOS magnetic fields. The application of these results to the solar activity forecast is discussed.

  9. Polyalkoxybenzenes from plants. 5. Parsley seed extract in synthesis of azapodophyllotoxins featuring strong tubulin destabilizing activity in the sea urchin embryo and cell culture assays.

    PubMed

    Semenova, Marina N; Kiselyov, Alex S; Tsyganov, Dmitry V; Konyushkin, Leonid D; Firgang, Sergei I; Semenov, Roman V; Malyshev, Oleg R; Raihstat, Mikhail M; Fuchs, Fabian; Stielow, Anne; Lantow, Margareta; Philchenkov, Alex A; Zavelevich, Michael P; Zefirov, Nikolay S; Kuznetsov, Sergei A; Semenov, Victor V

    2011-10-27

    A series of 4-azapodophyllotoxin derivatives with modified rings B and E have been synthesized using allylpolyalkoxybenzenes from parsley seed oil. The targeted molecules were evaluated in vivo in a phenotypic sea urchin embryo assay for antimitotic and tubulin destabilizing activity. The most active compounds identified by the in vivo sea urchin embryo assay featured myristicin-derived ring E. These molecules were determined to be more potent than podophyllotoxin. Cytotoxic effects of selected molecules were further confirmed and evaluated by conventional assays with A549 and Jurkat human leukemic T-cell lines including cell growth inhibition, cell cycle arrest, cellular microtubule disruption, and induction of apoptosis. The ring B modification yielded 6-OMe substituted molecule as the most active compound. Finally, in Jurkat cells, compound induced caspase-dependent apoptosis mediated by the apical caspases-2 and -9 and not caspase-8, implying the involvement of the intrinsic caspase-9-dependent apoptotic pathway.

  10. Swollenin from Trichoderma reesei exhibits hydrolytic activity against cellulosic substrates with features of both endoglucanases and cellobiohydrolases.

    PubMed

    Andberg, Martina; Penttilä, Merja; Saloheimo, Markku

    2015-04-01

    The cellulolytic and hemicellulolytic enzymes of Trichoderma reesei comprise one of the best characterised enzyme systems involved in lignocellulose degradation. In this paper, swollenin (SWOI), a protein recognised based on its sequence similarity with plant expansins, has been characterised. SWOI and its catalytic domain were subjected to analysis of their hydrolytic activity on different soluble carbohydrate polymers. By measuring the production of reducing ends, zymogram-, and viscosity analysis, SWOI was shown to have activity on substrates containing β-1,4 glucosidic bonds, i.e. carboxymethyl cellulose, hydroxyethyl cellulose and β-glucan. The formation of oligosaccharides from β-glucan was analysed by HPLC and showed cellobiose as the main reaction product. SWOI was also able to hydrolyse soluble cello-oligosaccharides and the products formed were all consistent with SWOI cleaving a cellobiose unit off the substrate. In conclusion, the T. reesei swollenin showed a unique mode of action with similarities with action of both endoglucanases and cellobiohydrolases. PMID:25643956

  11. Structural features related to hydrolytic activity against ceftazidime of plasmid-mediated SHV-type CAZ-5 beta-lactamase.

    PubMed Central

    Péduzzi, J; Barthélémy, M; Tiwari, K; Mattioni, D; Labia, R

    1989-01-01

    Tryptic peptides of the novel ceftazidimase CAZ-5 were sequenced by manual Edman degradation and aligned according to strong homology (more than 98%) with SHV-1 and SHV-2 beta-lactamase sequences. CAZ-5 differed from SHV-1 by five amino acid substitutions. Unusually high activity of CAZ-5 towards ceftazidime was imputed to substitution of a Lys for a Glu at position 214 of the mature protein. PMID:2694955

  12. Network and User-Perceived Performance of Web Page Retrievals

    NASA Technical Reports Server (NTRS)

    Kruse, Hans; Allman, Mark; Mallasch, Paul

    1998-01-01

    The development of the HTTP protocol has been driven by the need to improve the network performance of the protocol by allowing the efficient retrieval of multiple parts of a web page without the need for multiple simultaneous TCP connections between a client and a server. We suggest that the retrieval of multiple page elements sequentially over a single TCP connection may result in a degradation of the perceived performance experienced by the user. We attempt to quantify this perceived degradation through the use of a model which combines a web retrieval simulation and an analytical model of TCP operation. Starting with the current HTTP/l.1 specification, we first suggest a client@side heuristic to improve the perceived transfer performance. We show that the perceived speed of the page retrieval can be increased without sacrificing data transfer efficiency. We then propose a new client/server extension to the HTTP/l.1 protocol to allow for the interleaving of page element retrievals. We finally address the issue of the display of advertisements on web pages, and in particular suggest a number of mechanisms which can make efficient use of IP multicast to send advertisements to a number of clients within the same network.

  13. Automatic comic page image understanding based on edge segment analysis

    NASA Astrophysics Data System (ADS)

    Liu, Dong; Wang, Yongtao; Tang, Zhi; Li, Luyuan; Gao, Liangcai

    2013-12-01

    Comic page image understanding aims to analyse the layout of the comic page images by detecting the storyboards and identifying the reading order automatically. It is the key technique to produce the digital comic documents suitable for reading on mobile devices. In this paper, we propose a novel comic page image understanding method based on edge segment analysis. First, we propose an efficient edge point chaining method to extract Canny edge segments (i.e., contiguous chains of Canny edge points) from the input comic page image; second, we propose a top-down scheme to detect line segments within each obtained edge segment; third, we develop a novel method to detect the storyboards by selecting the border lines and further identify the reading order of these storyboards. The proposed method is performed on a data set consisting of 2000 comic page images from ten printed comic series. The experimental results demonstrate that the proposed method achieves satisfactory results on different comics and outperforms the existing methods.

  14. fMRI Activity in Posterior Parietal Cortex Relates to the Perceptual Use of Binocular Disparity for Both Signal-In-Noise and Feature Difference Tasks

    PubMed Central

    Patten, Matthew L.; Welchman, Andrew E.

    2015-01-01

    Visually guided action and interaction depends on the brain’s ability to (a) extract and (b) discriminate meaningful targets from complex retinal inputs. Binocular disparity is known to facilitate this process, and it is an open question how activity in different parts of the visual cortex relates to these fundamental visual abilities. Here we examined fMRI responses related to performance on two different tasks (signal-in-noise “coarse” and feature difference “fine” tasks) that have been widely used in previous work, and are believed to differentially target the visual processes of signal extraction and feature discrimination. We used multi-voxel pattern analysis to decode depth positions (near vs. far) from the fMRI activity evoked while participants were engaged in these tasks. To look for similarities between perceptual judgments and brain activity, we constructed ‘fMR-metric’ functions that described decoding performance as a function of signal magnitude. Thereafter we compared fMR-metric and psychometric functions, and report an association between judged depth and fMRI responses in the posterior parietal cortex during performance on both tasks. This highlights common stages of processing during perceptual performance on these tasks. PMID:26529314

  15. Identification of benzopyrone as a common structural feature in compounds with anti-inflammatory activity in a zebrafish phenotypic screen

    PubMed Central

    Robertson, Anne L.; Ogryzko, Nikolay V.; Henry, Katherine M.; Loynes, Catherine A.; Foulkes, Matthew J.; Meloni, Marco M.; Wang, Xingang; Ford, Christopher; Jackson, Malcolm; Ingham, Philip W.; Wilson, Heather L.; Farrow, Stuart N.; Solari, Roberto; Flower, Roderick J.; Jones, Simon; Whyte, Moira K. B.

    2016-01-01

    ABSTRACT Neutrophils are essential for host defence and are recruited to sites of inflammation in response to tissue injury or infection. For inflammation to resolve, these cells must be cleared efficiently and in a controlled manner, either by apoptosis or reverse migration. If the inflammatory response is not well-regulated, persistent neutrophils can cause damage to host tissues and contribute to the pathogenesis of chronic inflammatory diseases, which respond poorly to current treatments. It is therefore important to develop drug discovery strategies that can identify new therapeutics specifically targeting neutrophils, either by promoting their clearance or by preventing their recruitment. Our recent in vivo chemical genetic screen for accelerators of inflammation resolution identified a subset of compounds sharing a common chemical signature, the bicyclic benzopyrone rings. Here, we further investigate the mechanisms of action of the most active of this chemical series, isopimpinellin, in our zebrafish model of neutrophilic inflammation. We found that this compound targets both the recruitment and resolution phases of the inflammatory response. Neutrophil migration towards a site of injury is reduced by isopimpinellin and this occurs as a result of PI3K inhibition. We also show that isopimpinellin induces neutrophil apoptosis to drive inflammation resolution in vivo using a new zebrafish reporter line detecting in vivo neutrophil caspase-3 activity and allowing quantification of flux through the apoptotic pathway in real time. Finally, our studies reveal that clinically available ‘cromones’ are structurally related to isopimpinellin and have previously undescribed pro-resolution activity in vivo. These findings could have implications for the therapeutic use of benzopyrones in inflammatory disease. PMID:27079522

  16. Characterization and Comparison of the Structural Features, Immune-Modulatory and Anti-Avian Influenza Virus Activities Conferred by Three Algal Sulfated Polysaccharides.

    PubMed

    Song, Lin; Chen, Xiaolin; Liu, Xiaodong; Zhang, Fubo; Hu, Linfeng; Yue, Yang; Li, Kecheng; Li, Pengcheng

    2015-12-29

    Three marine macroalgae, i.e., Grateloupia filicina, Ulva pertusa and Sargassum qingdaoense, were selected as the deputies of Rhodophyta, Chlorophyta and Ochrophyta for comparative analysis of the molecular structures and biological activities of sulfated polysaccharides (SP). The ratio of water-soluble polysaccharides, the monosaccharide composition and the sulfated contents of three extracted SPs were determined, and their structures were characterized by Fourier transformation infrared spectroscopy. In addition, biological activity analysis showed that all three SPs had immune-modulatory activity both in vitro and in vivo, and SPs from S. qingdaoense had the best effect. Further bioassays showed that three SPs could not only enhance the immunity level stimulated by inactivated avian influenza virus (AIV) in vivo but also significantly inhibited the activity of activated AIV (H9N2 subtype) in vitro. G. filicina SP exhibited the strongest anti-AIV activity. These results revealed the variations in structural features and bioactivities among three SPs and indicated the potential adjuvants for immune-enhancement and anti-AIV.

  17. Characterization and Comparison of the Structural Features, Immune-Modulatory and Anti-Avian Influenza Virus Activities Conferred by Three Algal Sulfated Polysaccharides

    PubMed Central

    Song, Lin; Chen, Xiaolin; Liu, Xiaodong; Zhang, Fubo; Hu, Linfeng; Yue, Yang; Li, Kecheng; Li, Pengcheng

    2015-01-01

    Three marine macroalgae, i.e., Grateloupia filicina, Ulva pertusa and Sargassum qingdaoense, were selected as the deputies of Rhodophyta, Chlorophyta and Ochrophyta for comparative analysis of the molecular structures and biological activities of sulfated polysaccharides (SP). The ratio of water-soluble polysaccharides, the monosaccharide composition and the sulfated contents of three extracted SPs were determined, and their structures were characterized by Fourier transformation infrared spectroscopy. In addition, biological activity analysis showed that all three SPs had immune-modulatory activity both in vitro and in vivo, and SPs from S. qingdaoense had the best effect. Further bioassays showed that three SPs could not only enhance the immunity level stimulated by inactivated avian influenza virus (AIV) in vivo but also significantly inhibited the activity of activated AIV (H9N2 subtype) in vitro. G. filicina SP exhibited the strongest anti-AIV activity. These results revealed the variations in structural features and bioactivities among three SPs and indicated the potential adjuvants for immune-enhancement and anti-AIV. PMID:26729137

  18. Characterization and Comparison of the Structural Features, Immune-Modulatory and Anti-Avian Influenza Virus Activities Conferred by Three Algal Sulfated Polysaccharides.

    PubMed

    Song, Lin; Chen, Xiaolin; Liu, Xiaodong; Zhang, Fubo; Hu, Linfeng; Yue, Yang; Li, Kecheng; Li, Pengcheng

    2016-01-01

    Three marine macroalgae, i.e., Grateloupia filicina, Ulva pertusa and Sargassum qingdaoense, were selected as the deputies of Rhodophyta, Chlorophyta and Ochrophyta for comparative analysis of the molecular structures and biological activities of sulfated polysaccharides (SP). The ratio of water-soluble polysaccharides, the monosaccharide composition and the sulfated contents of three extracted SPs were determined, and their structures were characterized by Fourier transformation infrared spectroscopy. In addition, biological activity analysis showed that all three SPs had immune-modulatory activity both in vitro and in vivo, and SPs from S. qingdaoense had the best effect. Further bioassays showed that three SPs could not only enhance the immunity level stimulated by inactivated avian influenza virus (AIV) in vivo but also significantly inhibited the activity of activated AIV (H9N2 subtype) in vitro. G. filicina SP exhibited the strongest anti-AIV activity. These results revealed the variations in structural features and bioactivities among three SPs and indicated the potential adjuvants for immune-enhancement and anti-AIV. PMID:26729137

  19. Experimental Results on Statistical Approaches to Page Replacement Policies

    SciTech Connect

    LEUNG,VITUS J.; IRANI,SANDY

    2000-12-08

    This paper investigates the questions of what statistical information about a memory request sequence is useful to have in making page replacement decisions: Our starting point is the Markov Request Model for page request sequences. Although the utility of modeling page request sequences by the Markov model has been recently put into doubt, we find that two previously suggested algorithms (Maximum Hitting Time and Dominating Distribution) which are based on the Markov model work well on the trace data used in this study. Interestingly, both of these algorithms perform equally well despite the fact that the theoretical results for these two algorithms differ dramatically. We then develop succinct characteristics of memory access patterns in an attempt to approximate the simpler of the two algorithms. Finally, we investigate how to collect these characteristics in an online manner in order to have a purely online algorithm.

  20. Fast 3D Surface Extraction 2 pages (including abstract)

    SciTech Connect

    Sewell, Christopher Meyer; Patchett, John M.; Ahrens, James P.

    2012-06-05

    Ocean scientists searching for isosurfaces and/or thresholds of interest in high resolution 3D datasets required a tedious and time-consuming interactive exploration experience. PISTON research and development activities are enabling ocean scientists to rapidly and interactively explore isosurfaces and thresholds in their large data sets using a simple slider with real time calculation and visualization of these features. Ocean Scientists can now visualize more features in less time, helping them gain a better understanding of the high resolution data sets they work with on a daily basis. Isosurface timings (512{sup 3} grid): VTK 7.7 s, Parallel VTK (48-core) 1.3 s, PISTON OpenMP (48-core) 0.2 s, PISTON CUDA (Quadro 6000) 0.1 s.

  1. Coalition for Plasma Science (CPS) Education and Outreach Activities

    NASA Astrophysics Data System (ADS)

    Berry, L. A.

    2002-11-01

    The Coalition for Plasma Science (http://plasmacoalition.org/, CPS@plasmacoalition.org) is a group of institutions, organizations, and companies joining forces to increase awareness and understanding of plasma science and its many applications and benefits for society. Ongoing CPS educational activities include: (1) Construction and maintenance of a web site featuring "A Teacher's Guide to Plasma Science on the Web," a page that links to a wide range of plasma-related education sites, most of them analyzed for consistency with national science standards. The web site also directs visitors to our "Plasma Page," a brief, clear summary of plasma-related news; (2) Preparation of two-page articles on a wide range of plasma topics, including lighting, fusion, and space plasmas; and (3) Printing and distribution of an educational brochure entitled "Plasmas are Everywhere." The audience for these activities is primarily nontechnical, and includes students, teachers, and policy makers.

  2. A membrane page composer - Further developments. [for holographic memory system

    NASA Technical Reports Server (NTRS)

    Cosentino, L. S.; Stewart, W. C.

    1974-01-01

    Membrane page composers were made and were evaluated in a simulated holographic optical memory system. Calculated and experimentally determined electromechanical and optical characteristics of the circular membrane light valves used on the arrays are shown to be in close agreement. Several operating prototypes of 8 x 8 and 16 x 16 elements were produced. Measurements were made of switching time, optical contrast, and dynamic storage time of many cells on the devices. Digital patterns were stored in the arrays. The performance required of the page composer as a component of an optical memory system is considered. The fabrication techniques used can be easily extended to larger arrays.

  3. Key-phrase based classification of public health web pages.

    PubMed

    Dolamic, Ljiljana; Boyer, Célia

    2013-01-01

    This paper describes and evaluates the public health web pages classification model based on key phrase extraction and matching. Easily extendible both in terms of new classes as well as the new language this method proves to be a good solution for text classification faced with the total lack of training data. To evaluate the proposed solution we have used a small collection of public health related web pages created by a double blind manual classification. Our experiments have shown that by choosing the adequate threshold value the desired value for either precision or recall can be achieved.

  4. Digital database of mining-related features at selected historic and active phosphate mines, Bannock, Bear Lake, Bingham, and Caribou counties, Idaho

    USGS Publications Warehouse

    Causey, J. Douglas; Moyle, Phillip R.

    2001-01-01

    This report provides a description of data and processes used to produce a spatial database that delineates mining-related features in areas of historic and active phosphate mining in the core of the southeastern Idaho phosphate resource area. The data have varying degrees of accuracy and attribution detail. Classification of areas by type of mining-related activity at active mines is generally detailed; however, the spatial coverage does not differentiate mining-related surface disturbance features at many of the closed or inactive mines. Nineteen phosphate mine sites are included in the study. A total of 5,728 hc (14,154 ac), or more than 57 km2 (22 mi2), of phosphate mining-related surface disturbance are documented in the spatial coverage of the core of the southeast Idaho phosphate resource area. The study includes 4 active phosphate mines—Dry Valley, Enoch Valley, Rasmussen Ridge, and Smoky Canyon—and 15 historic phosphate mines—Ballard, Champ, Conda, Diamond Gulch, Gay, Georgetown Canyon, Henry, Home Canyon, Lanes Creek, Maybe Canyon, Mountain Fuel, Trail Canyon, Rattlesnake Canyon, Waterloo, and Wooley Valley. Spatial data on the inactive historic mines is relatively up-to-date; however, spatially described areas for active mines are based on digital maps prepared in early 1999. The inactive Gay mine has the largest total area of disturbance: 1,917 hc (4,736 ac) or about 19 km2 (7.4 mi2). It encompasses over three times the disturbance area of the next largest mine, the Conda mine with 607 hc (1,504 ac), and it is nearly four times the area of the Smoky Canyon mine, the largest of the active mines with 497 hc (1,228 ac). The wide range of phosphate mining-related surface disturbance features (approximately 80) were reduced to 13 types or features used in this study—adit and pit, backfilled mine pit, facilities, mine pit, ore stockpile, railroad, road, sediment catchment, tailings or tailings pond, topsoil stockpile, water reservoir, and disturbed

  5. Electronic Structure and Multicatalytic Features of Redox-Active Bis(arylimino)acenaphthene (BIAN)-Derived Ruthenium Complexes.

    PubMed

    Singha Hazari, Arijit; Ray, Ritwika; Hoque, Md Asmaul; Lahiri, Goutam Kumar

    2016-08-15

    The article examines the newly designed and structurally characterized redox-active BIAN-derived [Ru(trpy)(R-BIAN)Cl]ClO4 ([1a]ClO4-[1c]ClO4), [Ru(trpy)(R-BIAN)(H2O)](ClO4)2 ([3a](ClO4)2-[3c](ClO4)2), and BIAO-derived [Ru(trpy)(BIAO)Cl]ClO4 ([2a]ClO4) (trpy = 2,2':6',2''-terpyridine, R-BIAN = bis(arylimino)acenaphthene (R = H (1a(+), 3a(2+)), 4-OMe (1b(+), 3b(2+)), 4-NO2 (1c(+), 3c(2+)), BIAO = [N-(phenyl)imino]acenapthenone). The experimental (X-ray, (1)H NMR, spectroelectrochemistry, EPR) and DFT/TD-DFT calculations of 1a(n)-1c(n) or 2a(n) collectively establish {Ru(II)-BIAN(0)} or {Ru(II)-BIAO(0)} configuration in the native state, metal-based oxidation to {Ru(III)-BIAN(0)} or {Ru(III)-BIAO(0)}, and successive electron uptake processes by the α-diimine fragment, followed by trpy and naphthalene π-system of BIAN or BIAO, respectively. The impact of the electron-withdrawing NO2 function in the BIAN moiety in 1c(+) has been reflected in the five nearby reduction steps within the accessible potential limit of -2 V versus SCE, leading to a fully reduced BIAN(4-) state in [1c](4-). The aqua derivatives ({Ru(II)-OH2}, 3a(2+)-3c(2+)) undergo simultaneous 2e(-)/2H(+) transfer to the corresponding {Ru(IV)═O} state and the catalytic current associated with the Ru(IV)/Ru(V) response probably implies its involvement in the electrocatalytic water oxidation. The aqua derivatives (3a(2+)-3c(2+)) are efficient and selective precatalysts in transforming a wide variety of alkenes to corresponding epoxides in the presence of PhI(OAc)2 as an oxidant in CH2Cl2 at 298 K as well as oxidation of primary, secondary, and heterocyclic alcohols with a large substrate scope with H2O2 as the stoichiometric oxidant in CH3CN at 343 K. The involvement of the {Ru(IV)═O} intermediate as the active catalyst in both the oxidation processes has been ascertained via a sequence of experimental evidence. PMID:27482834

  6. Features of Recently Transmitted HIV-1 Clade C Viruses that Impact Antibody Recognition: Implications for Active and Passive Immunization

    PubMed Central

    Rademeyer, Cecilia; Korber, Bette; Seaman, Michael S.; Giorgi, Elena E.; Thebus, Ruwayhida; Robles, Alexander; Sheward, Daniel J.; Wagh, Kshitij; Carey, Brittany R.; Gao, Hongmei; Greene, Kelli M.; Tang, Haili; Marais, Jinny C.; Diphoko, Thabo E.; Hraber, Peter; Tumba, Nancy; Moore, Penny L.; Gray, Glenda E.; Kublin, James; McElrath, M. Juliana; Vermeulen, Marion; Middelkoop, Keren; Bekker, Linda-Gail; Hoelscher, Michael; Maboko, Leonard; Makhema, Joseph; Robb, Merlin L.; Abdool Karim, Salim; Abdool Karim, Quarraisha; Kim, Jerome H.; Hahn, Beatrice H.; Gao, Feng; Swanstrom, Ronald; Morris, Lynn; Montefiori, David C.; Williamson, Carolyn

    2016-01-01

    The development of biomedical interventions to reduce acquisition of HIV-1 infection remains a global priority, however their potential effectiveness is challenged by very high HIV-1 envelope diversity. Two large prophylactic trials in high incidence, clade C epidemic regions in southern Africa are imminent; passive administration of the monoclonal antibody VRC01, and active immunization with a clade C modified RV144-like vaccines. We have created a large representative panel of C clade viruses to enable assessment of antibody responses to vaccines and natural infection in Southern Africa, and we investigated the genotypic and neutralization properties of recently transmitted clade C viruses to determine how viral diversity impacted antibody recognition. We further explore the implications of these findings for the potential effectiveness of these trials. A panel of 200 HIV-1 Envelope pseudoviruses was constructed from clade C viruses collected within the first 100 days following infection. Viruses collected pre-seroconversion were significantly more resistant to serum neutralization compared to post-seroconversion viruses (p = 0.001). Over 13 years of the study as the epidemic matured, HIV-1 diversified (p = 0.0009) and became more neutralization resistant to monoclonal antibodies VRC01, PG9 and 4E10. When tested at therapeutic levels (10ug/ml), VRC01 only neutralized 80% of viruses in the panel, although it did exhibit potent neutralization activity against sensitive viruses (IC50 titres of 0.42 μg/ml). The Gp120 amino acid similarity between the clade C panel and candidate C-clade vaccine protein boosts (Ce1086 and TV1) was 77%, which is 8% more distant than between CRF01_AE viruses and the RV144 CRF01_AE immunogen. Furthermore, two vaccine signature sites, K169 in V2 and I307 in V3, associated with reduced infection risk in RV144, occurred less frequently in clade C panel viruses than in CRF01_AE viruses from Thailand. Increased resistance of pre

  7. Features of Recently Transmitted HIV-1 Clade C Viruses that Impact Antibody Recognition: Implications for Active and Passive Immunization.

    PubMed

    Rademeyer, Cecilia; Korber, Bette; Seaman, Michael S; Giorgi, Elena E; Thebus, Ruwayhida; Robles, Alexander; Sheward, Daniel J; Wagh, Kshitij; Garrity, Jetta; Carey, Brittany R; Gao, Hongmei; Greene, Kelli M; Tang, Haili; Bandawe, Gama P; Marais, Jinny C; Diphoko, Thabo E; Hraber, Peter; Tumba, Nancy; Moore, Penny L; Gray, Glenda E; Kublin, James; McElrath, M Juliana; Vermeulen, Marion; Middelkoop, Keren; Bekker, Linda-Gail; Hoelscher, Michael; Maboko, Leonard; Makhema, Joseph; Robb, Merlin L; Abdool Karim, Salim; Abdool Karim, Quarraisha; Kim, Jerome H; Hahn, Beatrice H; Gao, Feng; Swanstrom, Ronald; Morris, Lynn; Montefiori, David C; Williamson, Carolyn

    2016-07-01

    The development of biomedical interventions to reduce acquisition of HIV-1 infection remains a global priority, however their potential effectiveness is challenged by very high HIV-1 envelope diversity. Two large prophylactic trials in high incidence, clade C epidemic regions in southern Africa are imminent; passive administration of the monoclonal antibody VRC01, and active immunization with a clade C modified RV144-like vaccines. We have created a large representative panel of C clade viruses to enable assessment of antibody responses to vaccines and natural infection in Southern Africa, and we investigated the genotypic and neutralization properties of recently transmitted clade C viruses to determine how viral diversity impacted antibody recognition. We further explore the implications of these findings for the potential effectiveness of these trials. A panel of 200 HIV-1 Envelope pseudoviruses was constructed from clade C viruses collected within the first 100 days following infection. Viruses collected pre-seroconversion were significantly more resistant to serum neutralization compared to post-seroconversion viruses (p = 0.001). Over 13 years of the study as the epidemic matured, HIV-1 diversified (p = 0.0009) and became more neutralization resistant to monoclonal antibodies VRC01, PG9 and 4E10. When tested at therapeutic levels (10ug/ml), VRC01 only neutralized 80% of viruses in the panel, although it did exhibit potent neutralization activity against sensitive viruses (IC50 titres of 0.42 μg/ml). The Gp120 amino acid similarity between the clade C panel and candidate C-clade vaccine protein boosts (Ce1086 and TV1) was 77%, which is 8% more distant than between CRF01_AE viruses and the RV144 CRF01_AE immunogen. Furthermore, two vaccine signature sites, K169 in V2 and I307 in V3, associated with reduced infection risk in RV144, occurred less frequently in clade C panel viruses than in CRF01_AE viruses from Thailand. Increased resistance of pre

  8. Structural Features and Anti-coagulant Activity of the Sulphated Polysaccharide SPS-CF from a Green Alga Capsosiphon fulvescens.

    PubMed

    Synytsya, Andriy; Choi, Doo Jin; Pohl, Radek; Na, Ye Seul; Capek, Peter; Lattová, Erika; Taubner, Tomáš; Choi, Ji Won; Lee, Chang Won; Park, Jae Kweon; Kim, Woo Jung; Kim, Sung Min; Lee, Jisun; Park, Yong Il

    2015-12-01

    Previously, we reported that the sulphated polysaccharides (SPS)-CF, a water-soluble polysaccharide isolated and purified from Korean green alga Maesaengi (Capsosiphon fulvescens, Chlorophyta), is a glucuronogalactomannan based mainly on the monosaccharide composition determined by high-performance liquid chromatography (HPLC) analysis after 1-phenyl-3-methyl-5-pyrazolone (PMP) labelling of sugars in the acid (trifluoroacetic acid (TFA)) hydrolyzates of SPS-CF, which showed mannose (55.4 mol %), galactose (25.3 mol %) and glucuronic acid (16.3 mol %) as major sugars (Na et al., Int Immunopharmacol 10:364-370, 2010). However, the results of the present study re-performed for monosaccharide composition of this polysaccharide using, in addition to HPLC of PMP-labelled sugars, other separation methods, i.e. high-performance anion-exchange chromatography with pulsed amperometric detection (HPAEC-PAD), gas chromatography with flame ionising detection (GC-FID) and thin-layer chromatography (TLC), clearly demonstrated that the most prominent neutral monosaccharides of SPS-CF are xylose (38.6-49.4 mol %) and rhamnose (39.6-45 mol %), while mannose and galactose are present at a much lesser extent or in negligible amount. These extensive monosaccharide analyses, correlation nuclear magnetic resonance (NMR), electrospray ionization mass spectrometry (ESI-MS) and matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) measurements confirmed the sulphated glucuronorhamnoxylan (ulvan) type of SPS-CF polysaccharide, whose backbone is composed of alternating sequence of 4-linked L-rhamnose-3-sulphate and D-xylose residues (ulvobiose U3s) carrying monomeric D-glucuronic acid or D-glucuronic acid-3-sulphate on O-2 of some L-rhamnose-3-sulphate units as the side chains. The SPS-CF exhibited significant in vitro anti-coagulant activity by which the activated partial thromboplastin time (aPTT) and thrombin time (TT) were significantly prolonged. The results of this

  9. A tactile paging system for deaf-blind people, phase 1. [human factors engineering of bioinstrumentation

    NASA Technical Reports Server (NTRS)

    Baer, J. A.

    1976-01-01

    A tactile paging system for deaf-blind people has been brought from the concept stage to the development of a first model. The model consists of a central station that transmits coded information via radio link to an on-body (i.e., worn on the wrist) receiving unit, the output from which is a coded vibrotactile signal. The model is a combination of commercially available equipment, customized electronic circuits, and electromechanical transducers. The paging system facilitates communication to deaf-blind clients in an institutional environment as an aid in their training and other activities. Several subunits of the system were individually developed, tested, and integrated into an operating system ready for experimentation and evaluation. The operation and characteristics of the system are described and photographs are shown.

  10. Associations between Moderate-to-Vigorous Physical Activity and Neighbourhood Recreational Facilities: The Features of the Facilities Matter

    PubMed Central

    Lee, Ka Yiu; Lee, Paul H.; Macfarlane, Duncan

    2014-01-01

    Objectives: To examine the associations between objectively-assessed moderate-to-vigorous physical activity (MVPA) and perceived/objective measures of neighbourhood recreational facilities categorized into indoor or outdoor, public, residential or commercial facilities. The associations between facility perceptions and objectively-assessed numbers of recreational facilities were also examined. Method: A questionnaire was used on 480 adults to measure local facility perceptions, with 154 participants wearing ActiGraph accelerometers for ≥4 days. The objectively-assessed number of neighbourhood recreational facilities were examined using direct observations and Geographical Information System data. Results: Both positive and negative associations were found between MVPA and perceived/objective measures of recreational facilities. Some associations depended on whether the recreational facilities were indoor or outdoor, public or residential facilities. The objectively-assessed number of most public recreational facilities was associated with the corresponding facility perceptions, but the size of effect was generally lower than for residential recreational facilities. Conclusions: The objectively-assessed number of residential outdoor table tennis courts and public indoor swimming pools, the objectively-assessed presence of tennis courts and swimming pools, and the perceived presence of bike lanes and swimming pools were positive determinants of MVPA. It is suggested to categorize the recreational facilities into smaller divisions in order to identify unique associations with MVPA. PMID:25485980

  11. A Detailed Data-Driven Network Model of Prefrontal Cortex Reproduces Key Features of In Vivo Activity

    PubMed Central

    Hass, Joachim; Hertäg, Loreen; Durstewitz, Daniel

    2016-01-01

    The prefrontal cortex is centrally involved in a wide range of cognitive functions and their impairment in psychiatric disorders. Yet, the computational principles that govern the dynamics of prefrontal neural networks, and link their physiological, biochemical and anatomical properties to cognitive functions, are not well understood. Computational models can help to bridge the gap between these different levels of description, provided they are sufficiently constrained by experimental data and capable of predicting key properties of the intact cortex. Here, we present a detailed network model of the prefrontal cortex, based on a simple computationally efficient single neuron model (simpAdEx), with all parameters derived from in vitro electrophysiological and anatomical data. Without additional tuning, this model could be shown to quantitatively reproduce a wide range of measures from in vivo electrophysiological recordings, to a degree where simulated and experimentally observed activities were statistically indistinguishable. These measures include spike train statistics, membrane potential fluctuations, local field potentials, and the transmission of transient stimulus information across layers. We further demonstrate that model predictions are robust against moderate changes in key parameters, and that synaptic heterogeneity is a crucial ingredient to the quantitative reproduction of in vivo-like electrophysiological behavior. Thus, we have produced a physiologically highly valid, in a quantitative sense, yet computationally efficient PFC network model, which helped to identify key properties underlying spike time dynamics as observed in vivo, and can be harvested for in-depth investigation of the links between physiology and cognition. PMID:27203563

  12. Common and distinct features of mammary tumors driven by Pten-deletion or activating Pik3ca mutation

    PubMed Central

    Liu, Jeff C.; Wang, Dong-Yu; Egan, Sean E.; Zacksenhaus, Eldad

    2016-01-01

    PTEN loss and PIK3CA activation both promote the accumulation of phosphatidylinositol (3, 4, 5)-trisphosphate (PIP3). While these proteins also have distinct biochemical functions, beyond the regulation of PIP3, little is known about the consequences of these differences in vivo. Here, we directly compared cancer signalling in mammary tumors from MMTV-Cre:Ptenf/f and MMTV-Cre:Pik3caLSL-H1047R mice. Using unsupervised hierarchical clustering we found that whereas MMTV-Cre:Pik3caLSL-H1047R-derived tumors fall into two separate groups, designated squamous-likeEx and class14Ex, MMTV-Cre:Ptenf/f tumors cluster as one group together with PIK3CAH1047R class14Ex, exhibiting a ‘luminal’ expression profile. Gene Set Enrichment Analysis (GSEA) of PtenΔ and PIK3CAH1047R class14Ex tumors revealed very similar profiles of signalling pathways as well as some interesting differences. Analysis of 18 signalling signatures revealed that PI3K signalling is significantly induced whereas EGFR signalling is significantly reduced in PtenΔ versus PIK3CAH1047R tumors. Thus, PtenΔ and PIK3CAH1047R tumors exhibit discernable differences that may impact tumorigenesis and response to therapy. PMID:26814435

  13. Common fragile sites are conserved features of human and mouse chromosomes and relate to large active genes

    PubMed Central

    Helmrich, Anne; Stout-Weider, Karen; Hermann, Klaus; Schrock, Evelin; Heiden, Thomas

    2006-01-01

    Common fragile sites (CFSs) are seen as chromosomal gaps and breaks brought about by inhibition of replication, and it is thought that they cluster with tumor breakpoints. This study presents a comprehensive analysis using conventional and molecular cytogenetic mapping of CFSs and their expression frequencies in two mouse strains, BALB/c and C57BL/6, and in human probands. Here we show that induced mouse CFSs relate to sites of spontaneous gaps and breaks and that CFS expression levels in chromosome bands are conserved between the two mouse strains and between syntenic mouse and human DNA segments. Furthermore, four additional mouse CFSs were found to be homologous to human CFSs on the molecular cytogenetic level (Fra2D-FRA2G, Fra4C2-FRA9E, Fra6A3.1-FRA7G, and Fra6B1-FRA7H), increasing the number of such CFSs already described in the literature to eight. Contrary to previous reports, DNA helix flexibility is not increased in the 15 human and eight mouse CFSs molecularly defined so far, compared to large nonfragile control regions. Our findings suggest that the mechanisms that provoke instability at CFSs are evolutionarily conserved. The role that large transcriptionally active genes may play in CFS expression is discussed. PMID:16954539

  14. WALK 2.0: Examining the effectiveness of Web 2.0 features to increase physical activity in a ‘real world’ setting: an ecological trial

    PubMed Central

    Caperchione, Cristina M; Kolt, Gregory S; Savage, Trevor N; Rosenkranz, Richard R; Maeder, Anthony J; Vandelanotte, Corneel; Duncan, Mitch J; Van Itallie, Anetta; Tague, Rhys; Mummery, W Kerry

    2014-01-01

    Introduction Low levels of health-enhancing physical activity require novel approaches that have the potential to reach broad populations. Web-based interventions are a popular approach for behaviour change given their wide reach and accessibility. However, challenges with participant engagement and retention reduce the long-term maintenance of behaviour change. Web 2.0 features present a new and innovative online environment supporting greater interactivity, with the potential to increase engagement and retention. In order to understand the applicability of these innovative interventions for the broader population, ‘real-world’ interventions implemented under ‘everyday conditions’ are required. The aim of this study is to investigate the difference in physical activity behaviour between individuals using a traditional Web 1.0 website with those using a novel Web 2.0 website. Methods and analysis In this study we will aim to recruit 2894 participants. Participants will be recruited from individuals who register with a pre-existing health promotion website that currently provides Web 1.0 features (http://www.10000steps.org.au). Eligible participants who provide informed consent will be randomly assigned to one of the two trial conditions: the pre-existing 10 000 Steps website (with Web 1.0 features) or the newly developed WALK 2.0 website (with Web 2.0 features). Primary and secondary outcome measures will be assessed by self-report at baseline, 3 months and 12 months, and include: physical activity behaviour, height and weight, Internet self-efficacy, website usability, website usage and quality of life. Ethics and dissemination This study has received ethics approval from the University of Western Sydney Human Research Ethics Committee (Reference Number H8767) and has been funded by the National Health and Medical Research Council (Reference Number 589903). Study findings will be disseminated widely through peer-reviewed publications, academic

  15. Lead users’ ideas on core features to support physical activity in rheumatoid arthritis: a first step in the development of an internet service using participatory design

    PubMed Central

    2014-01-01

    Background Despite the growing evidence of the benefits of physical activity (PA) in individuals with rheumatoid arthritis (RA), the majority is not physically active enough. An innovative strategy is to engage lead users in the development of PA interventions provided over the internet. The aim was to explore lead users’ ideas and prioritization of core features in a future internet service targeting adoption and maintenance of healthy PA in people with RA. Methods Six focus group interviews were performed with a purposively selected sample of 26 individuals with RA. Data were analyzed with qualitative content analysis and quantification of participants’ prioritization of most important content. Results Six categories were identified as core features for a future internet service: up-to-date and evidence-based information and instructions, self-regulation tools, social interaction, personalized set-up, attractive design and content, and access to the internet service. The categories represented four themes, or core aspects, important to consider in the design of the future service: (1) content, (2) customized options, (3) user interface and (4) access and implementation. Conclusions This is, to the best of our knowledge, the first study involving people with RA in the development of an internet service to support the adoption and maintenance of PA. Participants helped identifying core features and aspects important to consider and further explore during the next phase of development. We hypothesize that involvement of lead users will make transfer from theory to service more adequate and user-friendly and therefore will be an effective mean to facilitate PA behavior change. PMID:24655757

  16. The 2006-2007 Active Phase Of Anomalous X-Ray Pulsar 4U 0142+61: Radiative and Timing Changes, Bursts, and Burst Spectral Features

    NASA Technical Reports Server (NTRS)

    Gavril, Fotis P.; Dib, Rim; Kaspi, Victoria M.

    2009-01-01

    After at least 6 years of quiescence, Anomalous X-ray Pulsar (AXP) 4U 0142+61 entered an active phase in 2006 March that lasted several months and included six X-ray bursts as well as many changes in the persistent X-ray emission. The bursts, the first seen from this AXP in >11 years of Rossi X-ray Timing Explorer monitoring, all occurred in the interval between 2006 April 6 and 2007 February 7. The burst durations ranged from 8-3x10(exp 3)s. The first five burst spectra are well modeled by blackbodies, with temperatures kT approx. 2 - 6 keV. However, the sixth burst had a complicated spectrum that is well characterized by a blackbody plus three emission features whose amplitude varied throughout the burst. The most prominent feature was at 14.0 keV. Upon entry into the active phase the pulsar showed a significant change in pulse morphology and a likely timing glitch. The glitch had a total frequency jump of (1.9+/-0.4)x10(exp -7) Hz, which recovered with a decay time of 17+/-2 days by more than the initial jump, implying a net spin-down of the pulsar. We discuss these events in the context of the magnetar model.

  17. General features

    SciTech Connect

    Wallace, R.E.

    1990-01-01

    The San Andreas fault system, a complex of faults that display predominantly large-scale strike slip, is part of an even more complex system of faults, isolated segments of the East Pacific Rise, and scraps of plates lying east of the East Pacific Rise that collectively separate the North American plate from the Pacific plate. This chapter briefly describes the San Andreas fault system, its setting along the Pacific Ocean margin of North America, its extent, and the patterns of faulting. Only selected characteristics are described, and many features are left for depictions on maps and figures.

  18. Activated human mesenchymal stem/stromal cells suppress metastatic features of MDA-MB-231 cells by secreting IFN-β.

    PubMed

    Yoon, N; Park, M S; Shigemoto, T; Peltier, G; Lee, R H

    2016-01-01

    Our recent study showed that human mesenchymal stem/stromal cells (hMSCs) are activated to express tumor necrosis factor (TNF)-α-related apoptosis-inducing ligand (TRAIL) by exposure to TNF-α and these activated hMSCs effectively induce apoptosis in triple-negative breast cancer MDA-MB-231 (MDA) cells in vitro and in vivo. Here, we further demonstrated that activated hMSCs not only induced apoptosis of MDA cells but also reduced metastatic features in MDA cells. These activated hMSC-exposed MDA cells showed reduced tumorigenicity and suppressed formation of lung metastasis when implanted in the mammary fat pad. Surprisingly, the activated hMSC-exposed MDA cells increased TRAIL expression, resulting in apoptosis in MDA cells. Interestingly, upregulation of TRAIL in MDA cells was mediated by interferon-beta (IFN-β) secreted from activated hMSCs. Furthermore, IFN-β in activated hMSCs was induced by RNA and DNA released from apoptotic MDA cells in absent in melanoma 2 (AIM2) and IFN induced with helicase C domain 1 (IFIH1)-dependent manners. These observations were only seen in the TRAIL-sensitive breast cancer cell lines but not in the TRAIL-resistant breast cancer cell lines. Consistent with these results, Kaplan-Meier survival analysis also showed that lack of innate sensors detecting DNA or RNA is strongly associated with poor survival in estrogen receptor-negative breast cancer patients. In addition, cancer-associated fibroblasts (CAF) isolated from a breast cancer patient were also able to express TRAIL and IFN-β upon DNA and RNA stimulation. Therefore, our results suggest that the crosstalk between TRAIL-sensitive cancer cells and stromal cells creates a tumor-suppressive microenvironment and further provide a novel therapeutic approach to target stromal cells within cancer microenvironment for TRAIL sensitive cancer treatment. PMID:27077807

  19. Activated human mesenchymal stem/stromal cells suppress metastatic features of MDA-MB-231 cells by secreting IFN-β

    PubMed Central

    Yoon, N; Park, M S; Shigemoto, T; Peltier, G; Lee, R H

    2016-01-01

    Our recent study showed that human mesenchymal stem/stromal cells (hMSCs) are activated to express tumor necrosis factor (TNF)-α-related apoptosis-inducing ligand (TRAIL) by exposure to TNF-α and these activated hMSCs effectively induce apoptosis in triple-negative breast cancer MDA-MB-231 (MDA) cells in vitro and in vivo. Here, we further demonstrated that activated hMSCs not only induced apoptosis of MDA cells but also reduced metastatic features in MDA cells. These activated hMSC-exposed MDA cells showed reduced tumorigenicity and suppressed formation of lung metastasis when implanted in the mammary fat pad. Surprisingly, the activated hMSC-exposed MDA cells increased TRAIL expression, resulting in apoptosis in MDA cells. Interestingly, upregulation of TRAIL in MDA cells was mediated by interferon-beta (IFN-β) secreted from activated hMSCs. Furthermore, IFN-β in activated hMSCs was induced by RNA and DNA released from apoptotic MDA cells in absent in melanoma 2 (AIM2) and IFN induced with helicase C domain 1 (IFIH1)-dependent manners. These observations were only seen in the TRAIL-sensitive breast cancer cell lines but not in the TRAIL-resistant breast cancer cell lines. Consistent with these results, Kaplan–Meier survival analysis also showed that lack of innate sensors detecting DNA or RNA is strongly associated with poor survival in estrogen receptor-negative breast cancer patients. In addition, cancer-associated fibroblasts (CAF) isolated from a breast cancer patient were also able to express TRAIL and IFN-β upon DNA and RNA stimulation. Therefore, our results suggest that the crosstalk between TRAIL-sensitive cancer cells and stromal cells creates a tumor-suppressive microenvironment and further provide a novel therapeutic approach to target stromal cells within cancer microenvironment for TRAIL sensitive cancer treatment. PMID:27077807

  20. Let's Meet Famous Women Artists. A Creative Art Activity Book. A Teacher's Guide Featuring 19 Famous Women Artists' Biographies and Enrichment/Research Activities.

    ERIC Educational Resources Information Center

    Badman, Jacqueline; Lewis-Spicer, Lisa

    This activity guide showcases the work of 19 women artists who have made outstanding contributions to the world of art in spite of the incredible obstacles society placed upon them. Artists, alphabetically presented, include: Sofonisba Anguissola, Rosa Bonheur, Deborah Butterfield, Rosalba Carriera, Janet Fish, Helen Frankenthaler, Giovanna…

  1. 16. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  2. 37. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    37. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  3. 34. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    34. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  4. 38. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    38. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  5. 26. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    26. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  6. 31. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    31. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  7. 30. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    30. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  8. 28. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    28. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  9. 19. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    19. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  10. 27. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    27. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  11. 21. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    21. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  12. 4. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  13. 14. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  14. 8. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  15. 9. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  16. 39. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    39. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  17. 7. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  18. 35. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    35. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  19. 5. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  20. 10. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  1. 29. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    29. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  2. 17. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    17. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  3. 22. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    22. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  4. 24. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    24. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  5. 12. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  6. 11. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  7. 32. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    32. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  8. 25. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    25. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  9. 3. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  10. 33. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    33. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  11. 1. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  12. 18. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    18. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  13. 20. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    20. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  14. 23. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    23. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  15. 13. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  16. 15. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    15. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  17. 2. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  18. 36. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    36. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  19. 6. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. PHOTOCOPIES OF TITLE PAGE, BOOKPLATE, MEMBERSHIP CERTIFICATE AND PLATES ILLUSTRATING EXAMPLES OF CARPENTERS' WORK PUBLISHED IN ARTICLES OF THE CARPENTERS' COMPANY OF PHILADELPHIA AND THEIR RULES FOR MEASURING AND VALUING HOUSE CARPENTERS' WORK (Philadelphia: Hall and Sellars, 1786). - Carpenters' Company, Rule Book (carpentry manual), Philadelphia, Philadelphia County, PA

  20. Designing Web Pages That Are Usable and Accessible to All.

    ERIC Educational Resources Information Center

    Wheaton, Joe E.; Granello, Paul F.

    The Internet is a growing source of information for persons worldwide, but for many people with disabilities the Internet can be a confusing jumble of images, frames, scripts, and colors that make little sense. Although learning how to make Web pages accessible to all takes some effort, it is effort well spent for one very good reason:…

  1. Building interactive simulations in a Web page design program.

    PubMed

    Kootsey, J Mailen; Siriphongs, Daniel; McAuley, Grant

    2004-01-01

    A new Web software architecture, NumberLinX (NLX), has been integrated into a commercial Web design program to produce a drag-and-drop environment for building interactive simulations. NLX is a library of reusable objects written in Java, including input, output, calculation, and control objects. The NLX objects were added to the palette of available objects in the Web design program to be selected and dropped on a page. Inserting an object in a Web page is accomplished by adding a template block of HTML code to the page file. HTML parameters in the block must be set to user-supplied values, so the HTML code is generated dynamically, based on user entries in a popup form. Implementing the object inspector for each object permits the user to edit object attributes in a form window. Except for model definition, the combination of the NLX architecture and the Web design program permits construction of interactive simulation pages without writing or inspecting code. PMID:17271495

  2. 48 CFR 804.1102 - Vendor Information Pages (VIP) Database.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...://www.VetBiz.gov, and also must be registered in the Central Contractor Registration (CCR) (see 48 CFR... (VIP) Database. 804.1102 Section 804.1102 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS GENERAL ADMINISTRATIVE MATTERS Contract Execution 804.1102 Vendor Information Pages (VIP)...

  3. 48 CFR 804.1102 - Vendor Information Pages (VIP) Database.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...://www.VetBiz.gov, and also must be registered in the Central Contractor Registration (CCR) (see 48 CFR... (VIP) Database. 804.1102 Section 804.1102 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS GENERAL ADMINISTRATIVE MATTERS Contract Execution 804.1102 Vendor Information Pages (VIP)...

  4. 48 CFR 804.1102 - Vendor Information Pages (VIP) Database.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...://www.VetBiz.gov, and also must be registered in the Central Contractor Registration (CCR) (see 48 CFR... (VIP) Database. 804.1102 Section 804.1102 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS GENERAL ADMINISTRATIVE MATTERS Contract Execution 804.1102 Vendor Information Pages (VIP)...

  5. 48 CFR 804.1102 - Vendor Information Pages (VIP) Database.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...://www.VetBiz.gov, and also must be registered in the Central Contractor Registration (CCR) (see 48 CFR... (VIP) Database. 804.1102 Section 804.1102 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS GENERAL ADMINISTRATIVE MATTERS Contract Execution 804.1102 Vendor Information Pages (VIP)...

  6. 48 CFR 804.1102 - Vendor Information Pages (VIP) Database.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...://www.VetBiz.gov, and also must be registered in the Central Contractor Registration (CCR) (see 48 CFR... (VIP) Database. 804.1102 Section 804.1102 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS GENERAL ADMINISTRATIVE MATTERS Contract Execution 804.1102 Vendor Information Pages (VIP)...

  7. 7 CFR 3402.11 - Proposal cover page.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Proposal cover page. 3402.11 Section 3402.11 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE FOOD AND AGRICULTURAL SCIENCES NATIONAL NEEDS GRADUATE AND POSTGRADUATE FELLOWSHIP GRANTS PROGRAM Preparation of an Application § 3402.11...

  8. 7 CFR 3402.11 - Proposal cover page.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Proposal cover page. 3402.11 Section 3402.11 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE FOOD AND AGRICULTURAL SCIENCES NATIONAL NEEDS GRADUATE AND POSTGRADUATE FELLOWSHIP GRANTS PROGRAM Preparation of an Application § 3402.11...

  9. What Should Be On A School Library Web Page?

    ERIC Educational Resources Information Center

    Baumbach, Donna; Brewer, Sally; Renfroe, Matt

    2004-01-01

    As varied as the schools and the communities they serve, so too are the Web pages for the library media programs that serve them. This article provides guidelines for effective web design and the information that might be included, including reference resources, reference asistance, curriculum support, literacy advocacy, and dynamic material. An…

  10. 7 CFR 3402.11 - Proposal cover page.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 15 2012-01-01 2012-01-01 false Proposal cover page. 3402.11 Section 3402.11 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE FOOD AND AGRICULTURAL SCIENCES NATIONAL NEEDS GRADUATE AND POSTGRADUATE FELLOWSHIP GRANTS PROGRAM Preparation of an Application § 3402.11...

  11. On Apples and Onions: A Reply to Page.

    ERIC Educational Resources Information Center

    Phillips, Gerald M.

    1980-01-01

    Answers some of William Page's criticisms (see preceding article, EJ 227 456) regarding the use of rhetoritherapy v behavior therapy to deal with students who exhibit communication apprehension. Argues that rhetoritherapy deals with people who have problems, not with problems. It is concerned with what can be done about the problem, not what the…

  12. 8. Historic American Buildings Survey, From page 5, volume 26 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Historic American Buildings Survey, From page 5, volume 26 of the Castner Collection in the Print Room of the Free Library of Philadelphia, COPY OF c.1870 PHOTOGRAPH SHOWING NORTHEAST CORNER OF SIXTH AND ARCH STREETS-THE LEE HOUSE SIXTH FROM LEFT. - Robert M. Lee House & Law Office, 109-111 North Sixth Street, Philadelphia, Philadelphia County, PA

  13. 8. Historic American Buildings Survey, From page 18, volume 2 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Historic American Buildings Survey, From page 18, volume 2 of the Castner Collection in the Print Room of Free Library of Philadelphia, Logan Square. Negative is the gift of James F. O'Gorman COPY OF AN UNDATED DRAWING OF THE HALL VIEWED FROM NORTHEAST. - National Guard's Hall, 518-20 Race Street, Philadelphia, Philadelphia County, PA

  14. Taking Shakespeare from the Page to the Stage.

    ERIC Educational Resources Information Center

    Breen, Kathleen T.

    1993-01-01

    Describes an approach to teaching William Shakespeare by which one teacher had students take the plays from the page to the stage by becoming actors and directors as well as scholars. Shows ways of relating various plays to more contemporary works. (HB)

  15. College of DuPage Administrative Internship Program.

    ERIC Educational Resources Information Center

    College of DuPage, Glen Ellyn, IL.

    This paper describes the objectives, policies, and procedures of the College of DuPage's Administrative Internship Program, whereby faculty members can gain broad administrative experience in key administrative areas of the college. The program seeks not only to broaden the experience of the individual intern, but to promote empathy among faculty…

  16. 47 CFR 22.503 - Paging geographic area authorizations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 2 2014-10-01 2014-10-01 false Paging geographic area authorizations. 22.503 Section 22.503 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES.... 42 (Salt Lake City) 148-150, 152. 43 (San Francisco-Oakland-San Jose) 151, 162-165. 44 (Los...

  17. College of DuPage Student Portrait, Fall Quarter 1999.

    ERIC Educational Resources Information Center

    College of DuPage, Glen Ellyn, IL. Office of Research and Planning.

    The report profiles the College of DuPage's (COD) fall quarter 1999 student body. It presents a brief history of the college's enrollment and a comparison of enrollments with other Illinois community colleges. It also provides demographic information on current students. Additionally, enrollment information is included by program, division, and…

  18. 7 CFR 3402.11 - Proposal cover page.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Proposal cover page. 3402.11 Section 3402.11 Agriculture Regulations of the Department of Agriculture (Continued) COOPERATIVE STATE RESEARCH, EDUCATION, AND EXTENSION SERVICE, DEPARTMENT OF AGRICULTURE FOOD AND AGRICULTURAL SCIENCES NATIONAL...

  19. Exploring the Use of a Facebook Page in Anatomy Education

    ERIC Educational Resources Information Center

    Jaffar, Akram Abood

    2014-01-01

    Facebook is the most popular social media site visited by university students on a daily basis. Consequently, Facebook is the logical place to start with for integrating social media technologies into education. This study explores how a faculty-administered Facebook Page can be used to supplement anatomy education beyond the traditional…

  20. 54. PAGE TWO OF PLANS FOR EXISTING GRAND CANAL COURT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    54. PAGE TWO OF PLANS FOR EXISTING GRAND CANAL COURT (VIRGINIA COURT) ARCHED PEDESTRIAN BRIDGE OVER CARROLL CANAL Plan Sheet D-26358, Sheet No. 2 of 6 (delineated by Richard G. Carrizosa, January 1978) - Venice Canals, Community of Venice, Los Angeles, Los Angeles County, CA

  1. 56. PAGE FOUR OF PLANS FOR EXISTING GRAND CANAL COURT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    56. PAGE FOUR OF PLANS FOR EXISTING GRAND CANAL COURT (VIRGINIA COURT) ARCHED PEDESTRIAN BRIDGE OVER CARROLL CANAL Plan Sheet D-26358, Sheet No. 4 of 6 (delineated by William Loo, January 1978) - Venice Canals, Community of Venice, Los Angeles, Los Angeles County, CA

  2. 55. PAGE THREE OF PLANS FOR EXISTING GRAND CANAL COURT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    55. PAGE THREE OF PLANS FOR EXISTING GRAND CANAL COURT (VIRGINIA COURT) ARCHED PEDESTRIAN BRIDGE OVER CARROLL CANAL Plan Sheet D-26358, Sheet No. 3 of 6 (delineated by William Loo, January 1978) - Venice Canals, Community of Venice, Los Angeles, Los Angeles County, CA

  3. 57. PAGE FIVE OF PLANS FOR EXISTING GRAND CANAL COURT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    57. PAGE FIVE OF PLANS FOR EXISTING GRAND CANAL COURT (VIRGINIA COURT) ARCHED PEDESTRIAN BRIDGE OVER CARROLL CANAL Plan Sheet D-26358, Sheet No. 5 of 6 (delineated by Richard G. Carrizosa, January 1978) - Venice Canals, Community of Venice, Los Angeles, Los Angeles County, CA

  4. 46. PAGE TWO OF PLANS FOR THE THREE ORIGINAL ARCHED ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    46. PAGE TWO OF PLANS FOR THE THREE ORIGINAL ARCHED PEDESTRIAN BRIDGES OVER GRAND CANAL AT 25TH AVENUE, CARROLL CANAL AT GRAND CANAL COURT, AND EASTERN CANAL AT LINNIE CANAL COURT Plan Sheet B-191 (delineator unknown, April 1924) - Venice Canals, Community of Venice, Los Angeles, Los Angeles County, CA

  5. 45. PAGE ONE OF PLANS FOR THE THREE ORIGINAL ARCHED ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    45. PAGE ONE OF PLANS FOR THE THREE ORIGINAL ARCHED PEDESTRIAN BRIDGES OVER GRAND CANAL AT 25TH AVENUE, CARROLL CANAL AT GRAND CANAL COURT, AND EASTERN CANAL AT LINNIE CANAL COURT Plan Sheet B-190 (delineator unknown, April 1924) - Venice Canals, Community of Venice, Los Angeles, Los Angeles County, CA

  6. The Inquiry Page: Bringing Digital Libraries to Learners.

    ERIC Educational Resources Information Center

    Bruce, Bertram C.; Bishop, Ann Peterson; Heidorn, P. Bryan; Lunsford, Karen J.; Poulakos, Steven; Won, Mihye

    2003-01-01

    Discusses digital library development, particularly a national science digital library, and describes the Inquiry Page which focuses on building a constructivist environment using Web resources, collaborative processes, and knowledge that bridges digital libraries with users in K-12 schools, museums, community groups, or other organizations. (LRW)

  7. Ranking nodes in growing networks: When PageRank fails

    PubMed Central

    Mariani, Manuel Sebastian; Medo, Matúš; Zhang, Yi-Cheng

    2015-01-01

    PageRank is arguably the most popular ranking algorithm which is being applied in real systems ranging from information to biological and infrastructure networks. Despite its outstanding popularity and broad use in different areas of science, the relation between the algorithm’s efficacy and properties of the network on which it acts has not yet been fully understood. We study here PageRank’s performance on a network model supported by real data, and show that realistic temporal effects make PageRank fail in individuating the most valuable nodes for a broad range of model parameters. Results on real data are in qualitative agreement with our model-based findings. This failure of PageRank reveals that the static approach to information filtering is inappropriate for a broad class of growing systems, and suggest that time-dependent algorithms that are based on the temporal linking patterns of these systems are needed to better rank the nodes. PMID:26553630

  8. 22. PHOTOGRAPHIC ENLARGEMENT OF UPPER PHOTOGRAPH ON PAGE 986 IN ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    22. PHOTOGRAPHIC ENLARGEMENT OF UPPER PHOTOGRAPH ON PAGE 986 IN Keystone Coal Buyers Catalog, 1922, VIEW SOUTH, COMMUNITY OF ETHEL; ETHEL COAL COMPANY MINE SUPPLY BUILDING IS LOCATED IN MID-GROUND LEFT OF CENTER PARTIALLY OBSCURED BY ROOF OF HOUSE IN FOREGROUND - Ethel Coal Company & Supply Building, Left fork of Dingess Run (Ethel Hollow), Ethel, Logan County, WV

  9. 23. PHOTOGRAPHIC ENLARGEMENT OF UPPER PHOTOGRAPH ON PAGE 986 IN ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    23. PHOTOGRAPHIC ENLARGEMENT OF UPPER PHOTOGRAPH ON PAGE 986 IN Keystone Coal Buyers Catalog, 1922, VIEW SOUTH, COMMUNITY OF ETHEL; ETHEL COAL COMPANY MINE SUPPLY BUILDING IS LOCATED IN MID-GROUND IN CENTER PARTIALLY OBSCURED BY ROOF OF HOUSE IN FOREGROUND - Ethel Coal Company & Supply Building, Left fork of Dingess Run (Ethel Hollow), Ethel, Logan County, WV

  10. 21. PHOTOGRAPH OF PAGE 986 IN Keystone Coal Buyers Catalog, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    21. PHOTOGRAPH OF PAGE 986 IN Keystone Coal Buyers Catalog, 1922, UPPER PHOTOGRAPH, VIEW SOUTH, COMMUNITY OF ETHEL; ETHEL COAL COMPANY MINE SUPPLY BUILDING IS LOCATED IN MID-GROUND LEFT OF CENTER PARTIALLY OBSCURED BY ROOF OF HOUSE IN FOREGROUND - Ethel Coal Company & Supply Building, Left fork of Dingess Run (Ethel Hollow), Ethel, Logan County, WV

  11. Automatic Caption Localization for Photographs on World Wide Web Pages.

    ERIC Educational Resources Information Center

    Rowe, Neil C.; Frew, Brian

    1998-01-01

    Explores the indirect method of locating for indexing the likely explicit and implicit captions of photographs, using multimodal clues including the specific words used, syntax, surrounding layout of the Web page, and general appearance of the associated image. The MARIE-3 system thus avoids full image processing and full natural-language…

  12. 48 CFR 1852.215-81 - Proposal page limitations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Proposal page limitations. 1852.215-81 Section 1852.215-81 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE... metric standard format most closely approximating the described standard 81/2″×11″ size may also be...

  13. College of DuPage Institutional Portrait, 1999-2000.

    ERIC Educational Resources Information Center

    College of DuPage, Glen Ellyn, IL. Office of Research and Planning.

    This report profiles the College of DuPage (Illinois) and provides a quick reference regarding the institution. It contains information on facilities and land, finance, staff, college/student services, the Library, athletics, academic calendars, maps, and instructional programs. This report reflects the college structure as of September 1999 and…

  14. Building interactive simulations in a Web page design program.

    PubMed

    Kootsey, J Mailen; Siriphongs, Daniel; McAuley, Grant

    2004-01-01

    A new Web software architecture, NumberLinX (NLX), has been integrated into a commercial Web design program to produce a drag-and-drop environment for building interactive simulations. NLX is a library of reusable objects written in Java, including input, output, calculation, and control objects. The NLX objects were added to the palette of available objects in the Web design program to be selected and dropped on a page. Inserting an object in a Web page is accomplished by adding a template block of HTML code to the page file. HTML parameters in the block must be set to user-supplied values, so the HTML code is generated dynamically, based on user entries in a popup form. Implementing the object inspector for each object permits the user to edit object attributes in a form window. Except for model definition, the combination of the NLX architecture and the Web design program permits construction of interactive simulation pages without writing or inspecting code.

  15. Google's Web Page Ranking Applied to Different Topological Web Graph Structures.

    ERIC Educational Resources Information Center

    Meghabghab, George

    2001-01-01

    This research, part of the ongoing study to better understand Web page ranking on the Web, looks at a Web page as a graph structure or Web graph, and classifies different Web graphs in the new coordinate space (out-degree, in-degree). Google's Web ranking algorithm (Brin & Page, 1998) on ranking Web pages is applied in this new coordinate space.…

  16. Cold Adaptation, Ca2+ Dependency and Autolytic Stability Are Related Features in a Highly Active Cold-Adapted Trypsin Resistant to Autoproteolysis Engineered for Biotechnological Applications

    PubMed Central

    Olivera-Nappa, Alvaro; Reyes, Fernando; Andrews, Barbara A.; Asenjo, Juan A.

    2013-01-01

    Pig trypsin is routinely used as a biotechnological tool, due to its high specificity and ability to be stored as an inactive stable zymogen. However, it is not an optimum enzyme for conditions found in wound debriding for medical uses and trypsinization processes for protein analysis and animal cell culturing, where low Ca2+ dependency, high activity in mild conditions and easy inactivation are crucial. We isolated and thermodynamically characterized a highly active cold-adapted trypsin for medical and laboratory use that is four times more active than pig trypsin at 10° C and at least 50% more active than pig trypsin up to 50° C. Contrary to pig trypsin, this enzyme has a broad optimum pH between 7 and 10 and is very insensitive to Ca2+ concentration. The enzyme is only distantly related to previously described cryophilic trypsins. We built and studied molecular structure models of this trypsin and performed molecular dynamic calculations. Key residues and structures associated with calcium dependency and cryophilicity were identified. Experiments indicated that the protein is unstable and susceptible to autoproteolysis. Correlating experimental results and structural predictions, we designed mutations to improve the resistance to autoproteolysis and conserve activity for longer periods after activation. One single mutation provided around 25 times more proteolytic stability. Due to its cryophilic nature, this trypsin is easily inactivated by mild denaturation conditions, which is ideal for controlled proteolysis processes without requiring inhibitors or dilution. We clearly show that cold adaptation, Ca2+ dependency and autolytic stability in trypsins are related phenomena that are linked to shared structural features and evolve in a concerted fashion. Hence, both structurally and evolutionarily they cannot be interpreted and studied separately as previously done. PMID:23951314

  17. Blue native-PAGE analysis of Trichoderma harzianum secretome reveals cellulases and hemicellulases working as multienzymatic complexes.

    PubMed

    da Silva, Adelson Joel; Gómez-Mendoza, Diana Paola; Junqueira, Magno; Domont, Gilberto Barbosa; Ximenes Ferreira Filho, Edivaldo; de Sousa, Marcelo Valle; Ricart, Carlos André Ornelas

    2012-08-01

    Plant cell wall-degrading enzymes produced by microorganisms possess important biotechnological applications, including biofuel production. Some anaerobic bacteria are able to produce multienzymatic complexes called cellulosomes while filamentous fungi normally secrete individual hydrolytic enzymes that act synergistically for polysaccharide degradation. Here, we present evidence that the fungus Trichoderma harzianum, cultivated in medium containing the agricultural residue sugarcane bagasse, is able to secrete multienzymatic complexes. The T. harzianum secretome was firstly analyzed by 1D-BN (blue native)-PAGE that revealed several putative complexes. The three most intense 1D-BN-PAGE bands, named complexes [I], [II], and [III], were subsequently subjected to tricine SDS-PAGE that demonstrated that they were composed of smaller subunits. Zymographic assays were performed using 1D-BN-PAGE and 2D-BN/BN-PAGE demonstrating that the complexes bore cellulolytic and xylanolytic activities. The complexes [I], [II], and [III] were then trypsin digested and analyzed separately by LC-MS/MS that revealed their protein composition. Since T. harzianum has an unsequenced genome, a homology-driven proteomics approach provided a higher number of identified proteins than a conventional peptide-spectrum matching strategy. The results indicate that the complexes are formed by cellulolytic and hemicellulolytic enzymes and other proteins such as chitinase, cutinase, and swollenin, which may act synergistically to degrade plant cell wall components.

  18. Vertical Feature Mask Feature Classification Flag Extraction

    Atmospheric Science Data Center

    2013-03-28

      Vertical Feature Mask Feature Classification Flag Extraction This routine demonstrates extraction of the ... in a CALIPSO Lidar Level 2 Vertical Feature Mask feature classification flag value. It is written in Interactive Data Language (IDL) ...

  19. Registered report: The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

    PubMed Central

    Fiehn, Oliver; Showalter, Megan Reed; Schaner-Tooley, Christine E

    2016-01-01

    The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by conducting replications of selected experiments from a number of high-profile papers in the field of cancer biology. The papers, which were published between 2010 and 2012, were selected on the basis of citations and Altmetric scores (Errington et al., 2014). This Registered Report describes the proposed replication plan of key experiments from “The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate” by Ward and colleagues, published in Cancer Cell in 2010 (Ward et al., 2010). The experiments that will be replicated are those reported in Figures 2, 3 and 5. Ward and colleagues demonstrate the mutations in isocitrate dehydrogenase 2 (IDH2), commonly found in acute myeloid leukemia (AML), abrogate the enzyme’s wild-type activity and confer to the mutant neomorphic activity that produces the oncometabolite 2-hydroxyglutarate (2-HG) (Figures 2 and 3). They then show that elevated levels of 2-HG are correlated with mutations in IDH1 and IDH2 in AML patient samples (Figure 5). The Reproducibility Project: Cancer Biology is a collaboration between the Center for Open Science and Science Exchange and the results of the replications will be published by eLife. DOI: http://dx.doi.org/10.7554/eLife.12626.001 PMID:26943899

  20. Statistical properties of H-alpha and HXR flares in the cycle 23 in relation to sunspots and active regions detected from the Solar Feature Catalogues

    NASA Astrophysics Data System (ADS)

    Zharkova, V.; Zharkov, S.

    2006-12-01

    The statistical properties of H-alpha and hard X-ray solar flares are investigated in relation to the cycle variations in 1996-2006 of sunspots and active regions (plages) obtained from the automated Soar Feature Catalogues (SFC, http://solar.inf.brad.ac.uk). Cross-correlation analysis is carried out between flare sizes, locations, significance and active region/sunspot parameters including magnetic field extracted in SFC. Sunspot and plage area distributions reveals a strong North-South asymmetry of about 0.2 and the period of about 7-8 years for sunspots and of 0.5 and period of 9 years for plages with both asymmetries decreasing towards the next cycle minimum. The temporal distribution of solar flare occurrences in Northern and Southern hemispheres, at different latitudes and longitudes are compared with those of plage and sunspot areas and LOS magnetic fields. The spectral indices of HXR and gamma-ray emission wer used to estimate magnetic field components and their variations with the cycle. The application of these results to the solar activity forecast is discussed.

  1. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part III: leucocyte activation: a new feature for platelet concentrates?

    PubMed

    Dohan, David M; Choukroun, Joseph; Diss, Antoine; Dohan, Steve L; Dohan, Anthony J J; Mouhyi, Jaafar; Gogly, Bruno

    2006-03-01

    Platelet-rich fibrin (PRF) belongs to a new generation of platelet concentrates, with simplified processing and without biochemical blood handling. In this third article, we investigate the immune features of this biomaterial. During PRF processing, leucocytes could also secrete cytokines in reaction to the hemostatic and inflammatory phenomena artificially induced in the centrifuged tube. We therefore undertook to quantify 5 significant cell mediators within platelet poor plasma supernatant and PRF clot exudate serum: 3 proinflammatory cytokines (IL-1beta, IL-6, and TNF-alpha), an antiinflammatory cytokine (IL-4), and a key growth promoter of angiogenesis (VEGF). Our data are correlated with that obtained in plasma (nonactivated blood) and in sera (activated blood). These initial analyses revealed that PRF could be an immune regulation node with inflammation retrocontrol abilities. This concept could explain the reduction of postoperative infections when PRF is used as surgical additive.

  2. Video 3 of 8: Lesson Plan Feature on the Website

    NASA Video Gallery

    The Lesson Plan page provides lessons, activities and units. A search engine allows you to search by national standard, data or topics. These lesson plans engage students in science, technology, en...

  3. The 2006-2007 Active Phase of Anomalous X-Ray Pulsar 4U 0142+61: Radiative and Timing Changes, Bursts,and Burst Spectral Features

    NASA Technical Reports Server (NTRS)

    Gavriil, Fotis P.; Dib, Rim; Kaspi, Victoria M.

    2011-01-01

    After at least 6 years of quiescence, Anomalous X-ray Pulsar (AXP) 4U 0142+61 entered an active phase in 2006 March that lasted several months and included six X-ray bursts as well as many changes in the persistent X-ray emission. The bursts, the first seen from this AXP in > 11 years of Rossi X-ray Timing Explorer monitoring, all occurred in the interval between 2006 April 6 and 2007 February 7. The burst durations ranged from 0.4 - 1.8 x 10(exp 3) s. The first five burst spectra are well modeled by blackbodies, with temperatures kT approx 2 - 9 keV. However, the sixth burst had a complicated spectrum that is well characterized by a blackbody plus two emission features whose amplitude varied throughout the burst. The most prominent feature was at 14.0 keV. Upon entry into the active phase the pulsar showed a significant change in pulse morphology and a likely timing glitch. The glitch had a total frequency jump of (1.9+/-0.4) x 10(exp -7) Hz, which recovered with a decay time of 17+/-2 days by more than the initial jump, implying a net spin-down of the pulsar. Within the framework of the magnetar model, the net spin-down of the star could be explained by regions of the superfluid that rotate. slower than the rest. The bursts, flux enhancements, and pulse morphology changes can be explained as arising from crustal deformations due to stresses imposed by the highly twisted internal magnetic field. However, unlike other AXP outbursts, we cannot account for a major twist being implanted in the magnetosphere.

  4. Evaluation of a One-Page Report to Aid in Detecting Glaucomatous Damage

    PubMed Central

    Hood, Donald C.; Raza, Ali S.; De Moraes, Carlos G.; Alhadeff, Paula A.; Idiga, Juliet; Blumberg, Dana M.; Liebmann, Jeffrey M.; Ritch, Robert

    2014-01-01

    Purpose We assessed the use of a customized, one-page structure + function report for aiding in detection of glaucomatous damage. Methods Two individuals (report specialists), experienced in analyzing optical coherent tomography (OCT) and visual field (VF) results, examined a customized one-page report for 50 eyes from 50 patients who either had glaucoma or were glaucoma suspects. The report contained key features of OCT scans with VF information. All patients had 24-2 VFs with a mean deviation (MD) better than −6 dB. The report specialists classified each hemifield and eye as either glaucomatous or nonglaucomatous based upon only the customized report, either without (phase 1) or with (phase 2) 24-2 VF information included on the report. Their results were compared to the classifications made by 3 ophthalmologists (glaucoma specialists) based upon traditional measures, namely stereo photographs, 24-2 VFs, and a commercially available, OCT disc scan report. Results The two report specialists agreed on all but one eye and four hemifields in phase 1, and on all eyes and all but one hemifield in phase 2. In phase 2, they judged 31 eyes abnormal. Of these 31 eyes, 30 were judged abnormal by all three glaucoma specialists and the 31st by two of the three. Without the VF information (phase 1), one report specialist classified 1, and the other 2, of these 31 “abnormal” eyes as normal. Conclusions When using the one-page report, the experienced readers showed excellent inter-rater repeatability and diagnostic ability relative to glaucoma specialists. Translational Relevance This condensed report may help the clinician assess glaucomatous damage. PMID:25674357

  5. Building Interactive Simulations in Web Pages without Programming.

    PubMed

    Mailen Kootsey, J; McAuley, Grant; Bernal, Julie

    2005-01-01

    A software system is described for building interactive simulations and other numerical calculations in Web pages. The system is based on a new Java-based software architecture named NumberLinX (NLX) that isolates each function required to build the simulation so that a library of reusable objects could be assembled. The NLX objects are integrated into a commercial Web design program for coding-free page construction. The model description is entered through a wizard-like utility program that also functions as a model editor. The complete system permits very rapid construction of interactive simulations without coding. A wide range of applications are possible with the system beyond interactive calculations, including remote data collection and processing and collaboration over a network. PMID:17282319

  6. How to find mathematics on a scanned page

    NASA Astrophysics Data System (ADS)

    Fateman, Richard J.

    1999-12-01

    We describe the design of document analysis procedures to separate mathematics from ordinary text on a scanned page of mixed material. It is easy to observe that the accuracy of commercial OCR programs is helped by separating mixed material into two (or more) streams, with conventional non-math text handled by the usual OCR text-based-heuristics analysis. The second stream, consisting of material judged to be mathematics, can be fed to a specialized recognizer. If that fails to decode it, it can be passed on to yet a third stream including diagrams, logos, or other miscellaneous material, perhaps including halftones. We explore the extent to which this separation can be automated in the context of scanning archival material for a digital library project including mathematical and scientific journal pages.

  7. Feature Project--A Bright Idea.

    ERIC Educational Resources Information Center

    Tackabury, Pamela

    1985-01-01

    The teaching activities presented in this paper introduce elementary pupils to illuminated manuscripts of the Middle Ages, and, in doing so, integrate art and language and also provoke interest in history. The paper provides references, tells how to produce an illuminated calendar page (including getting background information on the history of…

  8. DuPage County chilled water storage project

    SciTech Connect

    Grumman, D.L.

    1998-10-01

    Between 1992 and 1995, the DuPage County Governmental Center in Wheaton, Illinois, commissioned a detailed analysis of its chilled water plant and distribution system, as well as its future needs and options for meeting those needs. The result was a 10,000 ton-hour (35,170 kWh) chilled water storage tank with associated components and controls. This paper describes that process and the system that resulted.

  9. Adaptation of web pages and images for mobile applications

    NASA Astrophysics Data System (ADS)

    Kopf, Stephan; Guthier, Benjamin; Lemelson, Hendrik; Effelsberg, Wolfgang

    2009-02-01

    In this paper, we introduce our new visualization service which presents web pages and images on arbitrary devices with differing display resolutions. We analyze the layout of a web page and simplify its structure and formatting rules. The small screen of a mobile device is used much better this way. Our new image adaptation service combines several techniques. In a first step, border regions which do not contain relevant semantic content are identified. Cropping is used to remove these regions. Attention objects are identified in a second step. We use face detection, text detection and contrast based saliency maps to identify these objects and combine them into a region of interest. Optionally, the seam carving technique can be used to remove inner parts of an image. Additionally, we have developed a software tool to validate, add, delete, or modify all automatically extracted data. This tool also simulates different mobile devices, so that the user gets a feeling of how an adapted web page will look like. We have performed user studies to evaluate our web and image adaptation approach. Questions regarding software ergonomics, quality of the adapted content, and perceived benefit of the adaptation were asked.

  10. Using Firefly Tools to Enhance Archive Web Pages

    NASA Astrophysics Data System (ADS)

    Roby, W.; Wu, X.; Ly, L.; Goldina, T.

    2013-10-01

    Astronomy web developers are looking for fast and powerful HTML 5/AJAX tools to enhance their web archives. We are exploring ways to make this easier for the developer. How could you have a full FITS visualizer or a Web 2.0 table that supports paging, sorting, and filtering in your web page in 10 minutes? Can it be done without even installing any software or maintaining a server? Firefly is a powerful, configurable system for building web-based user interfaces to access astronomy science archives. It has been in production for the past three years. Recently, we have made some of the advanced components available through very simple JavaScript calls. This allows a web developer, without any significant knowledge of Firefly, to have FITS visualizers, advanced table display, and spectrum plots on their web pages with minimal learning curve. Because we use cross-site JSONP, installing a server is not necessary. Web sites that use these tools can be created in minutes. Firefly was created in IRSA, the NASA/IPAC Infrared Science Archive (http://irsa.ipac.caltech.edu). We are using Firefly to serve many projects including Spitzer, Planck, WISE, PTF, LSST and others.

  11. Use of Quasi-SMILES and Monte Carlo Optimization to Develop Quantitative Feature Property/Activity Relationships (QFPR/QFAR) for Nanomaterials.

    PubMed

    Toropov, Andrey A; Rallo, Robert; Toropova, Alla P

    2015-01-01

    The CORAL software (http://www.insilico.eu/coral) has been used to develop quantitative feature-property/activity relationships (QFPRs/QFARs) for the prediction of endpoints related to different categories of nanomaterials. In contrast to previous models built up by using CORAL from a representation of the molecular structure by using simplified molecular input-line entry system (SMILES), the current QFPR/QFARs are based on an integrated representation of acting conditions (i.e., a combination of physicochemical and/or biochemical factors) of nanomaterials via the so-called quasi-SMILES notation. In contrast to traditional quantitative structure - property / activity relationships (QSPRs/QSARs), the new models are able to provide new insight on the conditions of acting of substances (e.g., chemicals and nanomaterials) independently of their molecular structure. The development and validation of the QFPR/QFAR models was carried out following the OECD principles. The statistical quality of models developed from quasi-SMILES is acceptable, with values for the determination coefficient in the range of 0.70 to 0.85 for various endpoints of environmental and human health relevance. Perspectives of the QFPR/QFAR and their interaction and overlapping with traditional QSPR/QSAR are also discussed. PMID:25961527

  12. Substation fire protection features

    SciTech Connect

    Hausheer, T.G.

    1995-10-01

    This paper describes Commonwealth Edison`s (ComEd) approach to substation fire protection. Substation fires can have a major operational, financial, as well as political impact on a utility. The overall Company philosophy encompasses both active and passive fire protection features to provide prompt detection, notification, and confinement of fire and its by-products. Conservatively designed smoke detection systems and floor and wall penetration seals form the backbone of this strategy. The Company has implemented a program to install these features in new and existing substations. Thus far these measures have been successful in mitigating the consequences of substation fires.

  13. XWRAPComposer: A Multi-Page Data Extraction Service for Bio-Computing Applications

    SciTech Connect

    Liu, L; Zhang, J; Han, W; Pu, C; Caverlee, J; Park, S; Critchlow, T; Coleman, M; Buttler, D

    2005-02-16

    This paper presents a service-oriented framework for the development of wrapper code generators, including the methodology of designing an effective wrapper program construction facility and a concrete implementation, called XWRAPComposer Three unique features distinguish XWRAPComposer from existing wrapper development approaches. First, XWRAPComposer is designed to enable multi-stage and multi-page data extraction. Second, XWRAPComposer is the only wrapper generation system that promotes the distinction of information extraction logic from query-answer control logic, allowing higher level of robustness against changes in the service provider's web site design or infrastructure. Third, XWRAPComposer provides a user-friendly plug-and-play interface, allowing seamless incorporation of external services and continuous changing service interfaces and data format.

  14. The Geological, Geomorphological Features and Kinematic Analysis of Active Faults Controlling Kemalpaşa Basin, Southwestern Part of Gediz Graben, Western Anatolia

    NASA Astrophysics Data System (ADS)

    Tepe, Çiǧdem; Sözbilir, Hasan

    2016-04-01

    The purpose of this study is to discuss the geological and geomorphological features of active faults controlling Kemalpaşa Basin. The study consists of basin-bounding faults expressions, kinematic and geomorphic analysis. Kemalpaşa Basin, which is approximately ENE trending and asymmetric graben is located in the southern part of Gediz Graben. Menderes Massif and Bornova Complex comprise the basement rocks of basin. Kızılca Formation, Sütçüler Formation and Alluvium uncomformably overlie the basement rocks. Kemalpaşa Basin which is one of the Quaternary basin in the Western Anatolia Extensional Province was developed at the structural border of the Spildaǧı Fault Zone in the north and the Kemalpaşa Fault in the south. Both the north and south margin-bounding faults of Kemalpaşa Basin are oblique-slip normal faults. According to the results of kinematic analysis, Kemalpaşa Basin has been formed under a NE-GW trending extensional tectonic regime. The variation in the relative degree of tectonic activity in Kemalpaşa Basin and its surroundings were interpreted a detailed geomorphic study of the fault-generated mountain fronts and drainage pattern of the both sides. To identify the impacts of active faults controlling the north and south margins of Kemalpaşa Basin on the geomorphological evolution, the geomorphic indices such as drainage basin geometries, triangular facets, axial river profiles have been determined and the degree of tectonic activity in the both sides of Kemalpaşa Basin has been numerically defined using morphometric indexes such as asymmetry factor (AF), hypsometric curve and integral (HI), valley floor width-to-height ratio (Vf) and mountain front sinuosity (Smf). In morphometric analysis, the both sides of the basin were investigated separating into two segments as the west and east. The values of HI (0,28-0,60), Vf (0,27-0,60) and Smf (1,3) calculated for the western part of the north margin compared with the values of HI (0

  15. A small-scale hyperacute compound eye featuring active eye tremor: application to visual stabilization, target tracking, and short-range odometry.

    PubMed

    Colonnier, Fabien; Manecy, Augustin; Juston, Raphaël; Mallot, Hanspeter; Leitel, Robert; Floreano, Dario; Viollet, Stéphane

    2015-02-25

    In this study, a miniature artificial compound eye (15 mm in diameter) called the curved artificial compound eye (CurvACE) was endowed for the first time with hyperacuity, using similar micro-movements to those occurring in the fly's compound eye. A periodic micro-scanning movement of only a few degrees enables the vibrating compound eye to locate contrasting objects with a 40-fold greater resolution than that imposed by the interommatidial angle. In this study, we developed a new algorithm merging the output of 35 local processing units consisting of adjacent pairs of artificial ommatidia. The local measurements performed by each pair are processed in parallel with very few computational resources, which makes it possible to reach a high refresh rate of 500 Hz. An aerial robotic platform with two degrees of freedom equipped with the active CurvACE placed over naturally textured panels was able to assess its linear position accurately with respect to the environment thanks to its efficient gaze stabilization system. The algorithm was found to perform robustly at different light conditions as well as distance variations relative to the ground and featured small closed-loop positioning errors of the robot in the range of 45 mm. In addition, three tasks of interest were performed without having to change the algorithm: short-range odometry, visual stabilization, and tracking contrasting objects (hands) moving over a textured background.

  16. Business Systems Branch Abilities, Capabilities, and Services Web Page

    NASA Technical Reports Server (NTRS)

    Cortes-Pena, Aida Yoguely

    2009-01-01

    During the INSPIRE summer internship I acted as the Business Systems Branch Capability Owner for the Kennedy Web-based Initiative for Communicating Capabilities System (KWICC), with the responsibility of creating a portal that describes the services provided by this Branch. This project will help others achieve a clear view ofthe services that the Business System Branch provides to NASA and the Kennedy Space Center. After collecting the data through the interviews with subject matter experts and the literature in Business World and other web sites I identified discrepancies, made the necessary corrections to the sites and placed the information from the report into the KWICC web page.

  17. Children's recognition of advertisements on television and on Web pages.

    PubMed

    Blades, Mark; Oates, Caroline; Li, Shiying

    2013-03-01

    In this paper we consider the issue of advertising to children. Advertising to children raises a number of concerns, in particular the effects of food advertising on children's eating habits. We point out that virtually all the research into children's understanding of advertising has focused on traditional television advertisements, but much marketing aimed at children is now via the Internet and little is known about children's awareness of advertising on the Web. One important component of understanding advertisements is the ability to distinguish advertisements from other messages, and we suggest that young children's ability to recognise advertisements on a Web page is far behind their ability to recognise advertisements on television. PMID:22543303

  18. Photocopy of copy of blueprint between pages 151 and 152 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of copy of blueprint between pages 151 and 152 in completion report and history of the U.S.A. General hospital no. 21, compiled and edited under the direction of Major W.J. Cameron, by T.R. Wieger, Chief Engineer. The report was dated April 1, 1919. A copy of the report (4003/14/29) is at the National Archives, military records (floor 13 W), Washington, D.C. - Fitzsimons General Hospital, Bounded by East Colfax to south, Peoria Street to west, Denver City/County & Adams County Line to north, & U.S. Route 255 to east, Aurora, Adams County, CO

  19. Using Facebook Page Insights Data to Determine Posting Best Practices in an Academic Health Sciences Library

    ERIC Educational Resources Information Center

    Houk, Kathryn M.; Thornhill, Kate

    2013-01-01

    Tufts University Hirsh Health Sciences Library created a Facebook page and a corresponding managing committee in March 2010. Facebook Page Insights data collected from the library's Facebook page were statistically analyzed to investigate patterns of user engagement. The committee hoped to improve posting practices and increase user…

  20. MedlinePlus FAQ: What's New on Medline Plus Page and Email Updates

    MedlinePlus

    ... faq/whatsnew.html Question: How is the What's New on MedlinePlus page and RSS feed different from ... this page, please enable JavaScript. Answer: The What's New on MedlinePlus page and RSS feed include alerts ...

  1. 37 CFR 42.24 - Page limits for petitions, motions, oppositions, and replies.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) Petition requesting post-grant review: 80 pages. (iii) Petition requesting covered business method patent... reply for which the waiver is necessary. (b) Patent owner responses and oppositions. The page limits set... admitted or denied. (1) The page limits for a patent owner preliminary response to petition are the same...

  2. Forum Page Letters in the "Straits Times" of Singapore during Relatively Free and Restricted Press Periods.

    ERIC Educational Resources Information Center

    Ramaprasad, Jyotika; Ong, James

    In order to identify the scope or limits of the practice of development journalism, a study examined the content of the Forum page in the "Straits Times" of Singapore during relatively free (1979-1980) and restricted (1986-1987) press periods. The study had two major objectives: (1) to study the nature of the Forum page (a readers' letter page in…

  3. Do-It-Yourself: A Special Library's Approach to Creating Dynamic Web Pages Using Commercial Off-The-Shelf Applications

    NASA Technical Reports Server (NTRS)

    Steeman, Gerald; Connell, Christopher

    2000-01-01

    Many librarians may feel that dynamic Web pages are out of their reach, financially and technically. Yet we are reminded in library and Web design literature that static home pages are a thing of the past. This paper describes how librarians at the Institute for Defense Analyses (IDA) library developed a database-driven, dynamic intranet site using commercial off-the-shelf applications. Administrative issues include surveying a library users group for interest and needs evaluation; outlining metadata elements; and, committing resources from managing time to populate the database and training in Microsoft FrontPage and Web-to-database design. Technical issues covered include Microsoft Access database fundamentals, lessons learned in the Web-to-database process (including setting up Database Source Names (DSNs), redesigning queries to accommodate the Web interface, and understanding Access 97 query language vs. Standard Query Language (SQL)). This paper also offers tips on editing Active Server Pages (ASP) scripting to create desired results. A how-to annotated resource list closes out the paper.

  4. Young children's ability to recognize advertisements in web page designs.

    PubMed

    Ali, Moondore; Blades, Mark; Oates, Caroline; Blumberg, Fran

    2009-03-01

    Identifying what is, and what is not an advertisement is the first step in realizing that an advertisement is a marketing message. Children can distinguish television advertisements from programmes by about 5 years of age. Although previous researchers have investigated television advertising, little attention has been given to advertisements in other media, even though other media, especially the Internet, have become important channels of marketing to children. We showed children printed copies of invented web pages that included advertisements, half of which had price information, and asked the children to point to whatever they thought was an advertisement. In two experiments we tested a total of 401 children, aged 6, 8, 10 and 12 years of age, from the United Kingdom and Indonesia. Six-year-olds recognized a quarter of the advertisements, 8-year-olds recognized half the advertisements, and the 10- and 12-year-olds recognized about three-quarters. Only the 10- and 12-year-olds were more likely to identify an advertisement when it included a price. We contrast our findings with previous results about the identification of television advertising, and discuss why children were poorer at recognizing web page advertisements. The performance of the children has implications for theories about how children develop an understanding of advertising. PMID:19972663

  5. Internet resources and web pages for pediatric surgeons.

    PubMed

    Lugo-Vicente, H

    2000-02-01

    The Internet, the largest network of connected computers, provides immediate, dynamic, and downloadable information. By re-architecturing the work place and becoming familiar with Internet resources, pediatric surgeons have anticipated the informatics capabilities of this computer-based technology creating a new vision of work and organization in such areas as patient care, teaching, and research. This review aims to highlight how Internet navigational technology can be a useful educational resource in pediatric surgery, examines web pages of interest, and defines ideas of network communication. Basic Internet resources are electronic mail, discussion groups, file transfer, and the Worldwide Web (WWW). Electronic mailing is the most useful resource extending the avenue of learning to an international audience through news or list-servers groups. Pediatric Surgery List Server, the most popular discussion group, is a constant forum for exchange of ideas, difficult cases, consensus on management, and development of our specialty. The WWW provides an all-in-one medium of text, image, sound, and video. Associations, departments, educational sites, organizations, peer-reviewed scientific journals and Medline database web pages of prime interest to pediatric surgeons have been developing at an amazing pace. Future developments of technological advance nurturing our specialty will consist of online journals, telemedicine, international chatting, computer-based training for surgical education, and centralization of cyberspace information into database search sites.

  6. Young children's ability to recognize advertisements in web page designs.

    PubMed

    Ali, Moondore; Blades, Mark; Oates, Caroline; Blumberg, Fran

    2009-03-01

    Identifying what is, and what is not an advertisement is the first step in realizing that an advertisement is a marketing message. Children can distinguish television advertisements from programmes by about 5 years of age. Although previous researchers have investigated television advertising, little attention has been given to advertisements in other media, even though other media, especially the Internet, have become important channels of marketing to children. We showed children printed copies of invented web pages that included advertisements, half of which had price information, and asked the children to point to whatever they thought was an advertisement. In two experiments we tested a total of 401 children, aged 6, 8, 10 and 12 years of age, from the United Kingdom and Indonesia. Six-year-olds recognized a quarter of the advertisements, 8-year-olds recognized half the advertisements, and the 10- and 12-year-olds recognized about three-quarters. Only the 10- and 12-year-olds were more likely to identify an advertisement when it included a price. We contrast our findings with previous results about the identification of television advertising, and discuss why children were poorer at recognizing web page advertisements. The performance of the children has implications for theories about how children develop an understanding of advertising.

  7. Cancer/Testis Antigen PAGE4, a Regulator of c-Jun Transactivation, Is Phosphorylated by Homeodomain-Interacting Protein Kinase 1, a Component of the Stress-Response Pathway

    PubMed Central

    2015-01-01

    Prostate-associated gene 4 (PAGE4) is a cancer/testis antigen that is typically restricted to the testicular germ cells but is aberrantly expressed in cancer. Furthermore, PAGE4 is developmentally regulated with dynamic expression patterns in the developing prostate and is also a stress-response protein that is upregulated in response to cellular stress. PAGE4 interacts with c-Jun, which is activated by the stress-response kinase JNK1, and plays an important role in the development and pathology of the prostate gland. Here, we have identified homeodomain-interacting protein kinase 1 (HIPK1), also a component of the stress-response pathway, as a kinase that phosphorylates PAGE4 at T51. We show that phosphorylation of PAGE4 is critical for its transcriptional activity since mutating this T residue abolishes its ability to potentiate c-Jun transactivation. In vitro single molecule FRET indicates phosphorylation results in compaction of (still) intrinsically disordered PAGE4. Interestingly, however, while our previous observations indicated that the wild-type nonphosphorylated PAGE4 protein interacted with c-Jun [RajagopalanK. et al. (2014) Biochim, Biophys. Acta1842, 154−16324263171], here we show that phosphorylation of PAGE4 weakens its interaction with c-Jun in vitro. These data suggest that phosphorylation induces conformational changes in natively disordered PAGE4 resulting in its decreased affinity for c-Jun to promote interaction of c-Jun with another, unidentified, partner. Alternatively, phosphorylated PAGE4 may induce transcription of a novel partner, which then potentiates c-Jun transactivation. Regardless, the present results clearly implicate PAGE4 as a component of the stress-response pathway and uncover a novel link between components of this pathway and prostatic development and disease. PMID:24559171

  8. European multicentre study to define disease activity criteria for systemic sclerosis.* I. Clinical and epidemiological features of 290 patients from 19 centres

    PubMed Central

    Della, R; Valentini, G; Bombardieri, S; Bencivelli, W; Silman, A; D'Angelo, S; Cerinic, M; Belch, J; Black, C; Becvar, R; Bruhlman, P; Cozzi, F; Czirjak, L; Drosos, A; Dziankowska, B; Ferri, C; Gabrielli, A; Giacomelli, R; Hayem, G; Inanc, M; McHugh, N; Nielsen, H; Scorza, R; Tirri, E; van den Hoogen, F H J; Vlachoyiannopoulo..., P

    2001-01-01

    OBJECTIVE—To investigate the existence of differences among European referral centres for systemic sclerosis (SSc) in the pattern of attendance and referral and in the clinical and therapeutical approaches.
METHODS—In 1995 the European Scleroderma Study Group initiated a multicentre prospective one year study whose aim was to define the disease activity criteria in SSc. During the study period each participating European centre was asked to enrol consecutive patients satisfying American College of Rheumatology criteria for SSc and to fill out for each of them a standardised clinical chart. Patients from various centres were compared and differences in epidemiological, clinical, and therapeutical aspects were analysed.
RESULTS—Nineteen different medical research centres consecutively recruited 290 patients. The patients could be divided into two subgroups: 173 with the limited (lSSc) and 117 with the diffuse (dSSc) form of the disease. The clinical and serological findings for the series of 290 patients seemed to be similar to data previously reported. However, when the data were analysed to elicit any differences between the participating centres, a high degree of variability emerged, in both epidemiological and clinical features and in the diagnostic and therapeutic approaches to the disease.
CONCLUSIONS—The clinical approach to SSc, not only in different countries but also in different centres within the same country, is not yet standardised. To overcome this problem, it will be necessary for the scientific community to draw up a standardised procedure for the management of patients with SSc. This would provide a common research tool for different centres engaged in research on this complex disease.

 PMID:11350847

  9. Cosmic Ink: Fragments from the Past on Journal Pages

    NASA Astrophysics Data System (ADS)

    Mandrino, A.; Gargano, M.; Gasperini, A.

    2015-04-01

    This contribution describes an editorial project started in 2012 to enhance the cultural heritage of the Italian observatories. It includes a regular column Cieli di inchiostro (Cosmic ink) devoted to promoting the astronomical historical archives and published in the Giornale di astronomia, a journal of the Società Astronomica Italiana. In every issue of the journal, a significant historical artifact is presented and described. This can be a letter, a diary page, a photograph, a map, a drawing, or another type of item pulled out of the archival folders to bring its history to light. The column is intended to invite historians, amateurs, and students to search and use the documents kept in the archives of the observatories.

  10. Credibility judgments in web page design – a brief review

    PubMed Central

    Selejan, O; Muresanu, DF; Popa, L; Muresanu-Oloeriu, I; Iudean, D; Buzoianu, A; Suciu, S

    2016-01-01

    Today, more than ever, knowledge that interfaces appearance analysis is a crucial point in human-computer interaction field has been accepted. As nowadays virtually anyone can publish information on the web, the credibility role has grown increasingly important in relation to the web-based content. Areas like trust, credibility, and behavior, doubled by overall impression and user expectation are today in the spotlight of research compared to the last period, when other pragmatic areas such as usability and utility were considered. Credibility has been discussed as a theoretical construct in the field of communication in the past decades and revealed that people tend to evaluate the credibility of communication primarily by the communicator’s expertise. Other factors involved in the content communication process are trustworthiness and dynamism as well as various other criteria but to a lower extent. In this brief review, factors like web page aesthetics, browsing experiences and user experience are considered. PMID:27453738

  11. Learning Layouts for Single-Page Graphic Designs.

    PubMed

    O'Donovan, Peter; Agarwala, Aseem; Hertzmann, Aaron

    2014-08-01

    This paper presents an approach for automatically creating graphic design layouts using a new energy-based model derived from design principles. The model includes several new algorithms for analyzing graphic designs, including the prediction of perceived importance, alignment detection, and hierarchical segmentation. Given the model, we use optimization to synthesize new layouts for a variety of single-page graphic designs. Model parameters are learned with Nonlinear Inverse Optimization (NIO) from a small number of example layouts. To demonstrate our approach, we show results for applications including generating design layouts in various styles, retargeting designs to new sizes, and improving existing designs. We also compare our automatic results with designs created using crowdsourcing and show that our approach performs slightly better than novice designers. PMID:26357371

  12. Credibility judgments in web page design - a brief review.

    PubMed

    Selejan, O; Muresanu, D F; Popa, L; Muresanu-Oloeriu, I; Iudean, D; Buzoianu, A; Suciu, S

    2016-01-01

    Today, more than ever, knowledge that interfaces appearance analysis is a crucial point in human-computer interaction field has been accepted. As nowadays virtually anyone can publish information on the web, the credibility role has grown increasingly important in relation to the web-based content. Areas like trust, credibility, and behavior, doubled by overall impression and user expectation are today in the spotlight of research compared to the last period, when other pragmatic areas such as usability and utility were considered. Credibility has been discussed as a theoretical construct in the field of communication in the past decades and revealed that people tend to evaluate the credibility of communication primarily by the communicator's expertise. Other factors involved in the content communication process are trustworthiness and dynamism as well as various other criteria but to a lower extent. In this brief review, factors like web page aesthetics, browsing experiences and user experience are considered.

  13. Collecting responses through Web page drag and drop.

    PubMed

    Britt, M Anne; Gabrys, Gareth

    2004-02-01

    This article describes how to collect responses from experimental participants using drag and drop on a Web page. In particular, we describe how drag and drop can be used in a text search task in which participants read a text and then locate and categorize certain elements of the text (e.g., to identify the main claim of a persuasive paragraph). Using this technique, participants respond by clicking on a text segment and dragging it to a screen field or icon. We have successfully used this technique in both the argument element identification experiment that we describe here and a tutoring system that we created to teach students to identify source characteristics while reading historical texts (Britt, Perfetti, Van Dyke, & Gabrys, 2000). The implementation described here exploits the capability of recent versions of Microsoft's Internet Explorer Web browser to handle embedded XML documents and drag and drop events.

  14. Credibility judgments in web page design - a brief review.

    PubMed

    Selejan, O; Muresanu, D F; Popa, L; Muresanu-Oloeriu, I; Iudean, D; Buzoianu, A; Suciu, S

    2016-01-01

    Today, more than ever, knowledge that interfaces appearance analysis is a crucial point in human-computer interaction field has been accepted. As nowadays virtually anyone can publish information on the web, the credibility role has grown increasingly important in relation to the web-based content. Areas like trust, credibility, and behavior, doubled by overall impression and user expectation are today in the spotlight of research compared to the last period, when other pragmatic areas such as usability and utility were considered. Credibility has been discussed as a theoretical construct in the field of communication in the past decades and revealed that people tend to evaluate the credibility of communication primarily by the communicator's expertise. Other factors involved in the content communication process are trustworthiness and dynamism as well as various other criteria but to a lower extent. In this brief review, factors like web page aesthetics, browsing experiences and user experience are considered. PMID:27453738

  15. Standards opportunities around data-bearing Web pages.

    PubMed

    Karger, David

    2013-03-28

    The evolving Web has seen ever-growing use of structured data, thanks to the way it enhances information authoring, querying, visualization and sharing. To date, however, most structured data authoring and management tools have been oriented towards programmers and Web developers. End users have been left behind, unable to leverage structured data for information management and communication as well as professionals. In this paper, I will argue that many of the benefits of structured data management can be provided to end users as well. I will describe an approach and tools that allow end users to define their own schemas (without knowing what a schema is), manage data and author (not program) interactive Web visualizations of that data using the Web tools with which they are already familiar, such as plain Web pages, blogs, wikis and WYSIWYG document editors. I will describe our experience deploying these tools and some lessons relevant to their future evolution.

  16. Learning Layouts for Single-Page Graphic Designs.

    PubMed

    O'Donovan, Peter; Agarwala, Aseem; Hertzmann, Aaron

    2014-08-01

    This paper presents an approach for automatically creating graphic design layouts using a new energy-based model derived from design principles. The model includes several new algorithms for analyzing graphic designs, including the prediction of perceived importance, alignment detection, and hierarchical segmentation. Given the model, we use optimization to synthesize new layouts for a variety of single-page graphic designs. Model parameters are learned with Nonlinear Inverse Optimization (NIO) from a small number of example layouts. To demonstrate our approach, we show results for applications including generating design layouts in various styles, retargeting designs to new sizes, and improving existing designs. We also compare our automatic results with designs created using crowdsourcing and show that our approach performs slightly better than novice designers.

  17. To Overcome HITS Rank Similarity Confliction of Web Pages using Weight Calculation and Rank Improvement

    NASA Astrophysics Data System (ADS)

    Nath, Rajender; Kumar, Naresh

    2011-12-01

    Search Engine gives an ordered list of web search results in response to a user query, wherein the important pages are usually displayed at the top with less important ones afterwards. It may be possible that the user may have to look for many screen results to get the required documents. In literatures, many page ranking algorithms has been given to find the page rank of a page. For example PageRank is considered in this work. This algorithm treats all the links equally when distributing rank scores. That's why this algorithm some time gives equal importance to all the pages. But in real this can not be happen because, if two pages have same rank then how we can judge which page is more important then other. So this paper proposes another idea to organize the search results and describe which page is more important when confliction of same rank is produced by the PageRank. So that the user can get more relevant and important results easily and in a short span of time.

  18. The impact of visual layout factors on performance in Web pages: a cross-language study.

    PubMed

    Parush, Avi; Shwarts, Yonit; Shtub, Avy; Chandra, M Jeya

    2005-01-01

    Visual layout has a strong impact on performance and is a critical factor in the design of graphical user interfaces (GUIs) and Web pages. Many design guidelines employed in Web page design were inherited from human performance literature and GUI design studies and practices. However, few studies have investigated the more specific patterns of performance with Web pages that may reflect some differences between Web page and GUI design. We investigated interactions among four visual layout factors in Web page design (quantity of links, alignment, grouping indications, and density) in two experiments: one with pages in Hebrew, entailing right-to-left reading, and the other with English pages, entailing left-to-right reading. Some performance patterns (measured by search times and eye movements) were similar between languages. Performance was particularly poor in pages with many links and variable densities, but it improved with the presence of uniform density. Alignment was not shown to be a performance-enhancing factor. The findings are discussed in terms of the similarities and differences in the impact of layout factors between GUIs and Web pages. Actual or potential applications of this research include specific guidelines for Web page design.

  19. NIAMS Kids Pages on Muscles, Joints, Skin and Bones

    MedlinePlus

    ... that will help you keep your bones, joints, muscles, and skin healthy for years to come. Have ... back often for updates and new features. Healthy Muscles Matter Healthy Skin Matters Healthy Joints Matter Healthy ...

  20. Socorro Students Translate NRAO Web Pages Into Spanish

    NASA Astrophysics Data System (ADS)

    2002-07-01

    Six Socorro High School students are spending their summer working at the National Radio Astronomy Observatory (NRAO) on a unique project that gives them experience in language translation, World Wide Web design, and technical communication. Under the project, called "Un puente a los cielos," the students are translating many of NRAO's Web pages on astronomy into Spanish. "These students are using their bilingual skills to help us make basic information about astronomy and radio telescopes available to the Spanish-speaking community," said Kristy Dyer, who works at NRAO as a National Science Foundation postdoctoral fellow and who developed the project and obtained funding for it from the National Aeronautics and Space Administration. The students are: Daniel Acosta, 16; Rossellys Amarante, 15; Sandra Cano, 16; Joel Gonzalez, 16; Angelica Hernandez, 16; and Cecilia Lopez, 16. The translation project, a joint effort of NRAO and the NM Tech physics department, also includes Zammaya Moreno, a teacher from Ecuador, Robyn Harrison, NRAO's education officer, and NRAO computer specialist Allan Poindexter. The students are translating NRAO Web pages aimed at the general public. These pages cover the basics of radio astronomy and frequently-asked questions about NRAO and the scientific research done with NRAO's telescopes. "Writing about science for non-technical audiences has to be done carefully. Scientific concepts must be presented in terms that are understandable to non-scientists but also that remain scientifically accurate," Dyer said. "When translating this type of writing from one language to another, we need to preserve both the understandability and the accuracy," she added. For that reason, Dyer recruited 14 Spanish-speaking astronomers from Argentina, Mexico and the U.S. to help verify the scientific accuracy of the Spanish translations. The astronomers will review the translations. The project is giving the students a broad range of experience. "They are

  1. PAGES-Powell North America 2k database

    NASA Astrophysics Data System (ADS)

    McKay, N.

    2014-12-01

    Syntheses of paleoclimate data in North America are essential for understanding long-term spatiotemporal variability in climate and for properly assessing risk on decadal and longer timescales. Existing reconstructions of the past 2,000 years rely almost exclusively on tree-ring records, which can underestimate low-frequency variability and rarely extend beyond the last millennium. Meanwhile, many records from the full spectrum of paleoclimate archives are available and hold the potential of enhancing our understanding of past climate across North America over the past 2000 years. The second phase of the Past Global Changes (PAGES) North America 2k project began in 2014, with a primary goal of assembling these disparate paleoclimate records into a unified database. This effort is currently supported by the USGS Powell Center together with PAGES. Its success requires grassroots support from the community of researchers developing and interpreting paleoclimatic evidence relevant to the past 2000 years. Most likely, fewer than half of the published records appropriate for this database are publicly archived, and far fewer include the data needed to quantify geochronologic uncertainty, or to concisely describe how best to interpret the data in context of a large-scale paleoclimatic synthesis. The current version of the database includes records that (1) have been published in a peer-reviewed journal (including evidence of the record's relationship to climate), (2) cover a substantial portion of the past 2000 yr (>300 yr for annual records, >500 yr for lower frequency records) at relatively high resolution (<50 yr/observation), and (3) have reasonably small and quantifiable age uncertainty. Presently, the database includes records from boreholes, ice cores, lake and marine sediments, speleothems, and tree rings. This poster presentation will display the site locations and basic metadata of the records currently in the database. We invite anyone with interest in

  2. Semantic Feature Distinctiveness and Frequency

    ERIC Educational Resources Information Center

    Lamb, Katherine M.

    2012-01-01

    Lexical access is the process in which basic components of meaning in language, the lexical entries (words) are activated. This activation is based on the organization and representational structure of the lexical entries. Semantic features of words, which are the prominent semantic characteristics of a word concept, provide important information…

  3. "Spacecraft Reveals Recent Geological Activity on the Moon": Exploring the Features of NASA Twitter Posts and Their Potential to Engage Adolescents

    ERIC Educational Resources Information Center

    Lesley, Mellinee

    2014-01-01

    Through a content analysis of 200 "tweets," this study was an exploration into the distinct features of text posted to NASA's "Twitter" site and the potential for these posts to serve as more engaging scientific text than traditional textbooks for adolescents. Results of the content analysis indicated the tweets and linked…

  4. A biplex approach to PageRank centrality: From classic to multiplex networks.

    PubMed

    Pedroche, Francisco; Romance, Miguel; Criado, Regino

    2016-06-01

    In this paper, we present a new view of the PageRank algorithm inspired by multiplex networks. This new approach allows to introduce a new centrality measure for classic complex networks and a new proposal to extend the usual PageRank algorithm to multiplex networks. We give some analytical relations between these new approaches and the classic PageRank centrality measure, and we illustrate the new parameters presented by computing them on real underground networks.

  5. A biplex approach to PageRank centrality: From classic to multiplex networks.

    PubMed

    Pedroche, Francisco; Romance, Miguel; Criado, Regino

    2016-06-01

    In this paper, we present a new view of the PageRank algorithm inspired by multiplex networks. This new approach allows to introduce a new centrality measure for classic complex networks and a new proposal to extend the usual PageRank algorithm to multiplex networks. We give some analytical relations between these new approaches and the classic PageRank centrality measure, and we illustrate the new parameters presented by computing them on real underground networks. PMID:27368791

  6. Transfer Learning across Feature-Rich Heterogeneous Feature Spaces via Feature-Space Remapping (FSR)

    PubMed Central

    Feuz, Kyle D.; Cook, Diane J.

    2016-01-01

    Transfer learning aims to improve performance on a target task by utilizing previous knowledge learned from source tasks. In this paper we introduce a novel heterogeneous transfer learning technique, Feature- Space Remapping (FSR), which transfers knowledge between domains with different feature spaces. This is accomplished without requiring typical feature-feature, feature instance, or instance-instance co-occurrence data. Instead we relate features in different feature-spaces through the construction of meta-features. We show how these techniques can utilize multiple source datasets to construct an ensemble learner which further improves performance. We apply FSR to an activity recognition problem and a document classification problem. The ensemble technique is able to outperform all other baselines and even performs better than a classifier trained using a large amount of labeled data in the target domain. These problems are especially difficult because in addition to having different feature-spaces, the marginal probability distributions and the class labels are also different. This work extends the state of the art in transfer learning by considering large transfer across dramatically different spaces. PMID:27019767

  7. Analyzing Web pages visual scanpaths: between and within tasks variability.

    PubMed

    Drusch, Gautier; Bastien, J M Christian

    2012-01-01

    In this paper, we propose a new method for comparing scanpaths in a bottom-up approach, and a test of the scanpath theory. To do so, we conducted a laboratory experiment in which 113 participants were invited to accomplish a set of tasks on two different websites. For each site, they had to perform two tasks that had to be repeated ounce. The data were analyzed using a procedure similar to the one used by Duchowski et al. [8]. The first step was to automatically identify, then label, AOIs with the mean-shift clustering procedure [19]. Then, scanpaths were compared two by two with a modified version of the string-edit method, which take into account the order of AOIs visualizations [2]. Our results show that scanpaths variability between tasks but within participants seems to be lower than the variability within task for a given participant. In other words participants seem to be more coherent when they perform different tasks, than when they repeat the same tasks. In addition, participants view more of the same AOI when they perform a different task on the same Web page than when they repeated the same task. These results are quite different from what predicts the scanpath theory. PMID:22316937

  8. Page segmentation using script identification vectors: A first look

    SciTech Connect

    Hochberg, J.; Cannon, M.; Kelly, P.; White, J.

    1997-07-01

    Document images in which different scripts, such as Chinese and Roman, appear on a single page pose a problem for optical character recognition (OCR) systems. This paper explores the use of script identification vectors in the analysis of multilingual document images. A script identification vector is calculated for each connected component in a document. The vector expresses the closest distance between the component and templates developed for each of thirteen scripts, including Arabic, Chinese, Cyrillic, and Roman. The authors calculate the first three principal components within the resulting thirteen-dimensional space for each image. By mapping these components to red, green, and blue, they can visualize the information contained in the script identification vectors. The visualization of several multilingual images suggests that the script identification vectors can be used to segment images into script-specific regions as large as several paragraphs or as small as a few characters. The visualized vectors also reveal distinctions within scripts, such as font in Roman documents, and kanji vs. kana in Japanese. Results are best for documents containing highly dissimilar scripts such as Roman and Japanese. Documents containing similar scripts, such as Roman and Cyrillic will require further investigation.

  9. Rotorcraft Aeromechanics Branch Home Page on the World Wide Web

    NASA Technical Reports Server (NTRS)

    Peterson, Randall L.; Warmbrodt, William (Technical Monitor)

    1996-01-01

    , strength, and location of the tip vortex, therefore changing the BVI acoustics of the rotor. The subwings are approximately 20% of the blade chord and increase the rotor radius by about 3 percent. Four different subwing configurations will be tested, including square tipped subwings with different angles of incidence. The ability of active controls to reduce BVI acoustics will also be assessed. The dynamic control system of the RTA will be used to implement open- and closed-loop active control techniques, including individual blade control. Open-loop testing will be conducted using a personal computer based, automated, real-time data acquisition system. This system features combined automated output of open loop control signals and automated data acquisition of the resulting test data. A final technique to alter the noise of the rotor will be examined. This will involve changing the number of blades from three to four. A four-bladed rotor hub has been fabricated on which the XV-15 blades will be mounted. While the solidity of the rotor will increase, much useful information can be gained by examining the changes in the thrust and RPM with four blades.

  10. Prestimulus oscillations in the alpha band of the EEG are modulated by the difficulty of feature discrimination and predict activation of a sensory discrimination process.

    PubMed

    Roberts, Daniel M; Fedota, John R; Buzzell, George A; Parasuraman, Raja; McDonald, Craig G

    2014-08-01

    Recent work has demonstrated that the occipital-temporal N1 component of the ERP is sensitive to the difficulty of visual discrimination, in a manner that cannot be explained by simple differences in low-level visual features, arousal, or time on task. These observations provide evidence that the occipital-temporal N1 component is modulated by the application of top-down control. However, the timing of this control process remains unclear. Previous work has demonstrated proactive, top-down modulation of cortical excitability for cued spatial attention or feature selection tasks. Here, the possibility that a similar top-down process facilitates performance of a difficult stimulus discrimination task is explored. Participants performed an oddball task at two levels of discrimination difficulty, with difficulty manipulated by modulating the similarity between target and nontarget stimuli. Discrimination processes and cortical excitability were assessed via the amplitude of the occipital-temporal N1 component and prestimulus alpha oscillation of the EEG, respectively. For correct discriminations, prestimulus alpha power was reduced, and the occipital-temporal N1 was enhanced in the hard relative to the easy condition. Furthermore, within the hard condition, prestimulus alpha power was reduced, and the occipital-temporal N1 was enhanced for correct relative to incorrect discriminations. The generation of ERPs contingent on relative prestimulus alpha power additionally suggests that diminished alpha power preceding stimulus onset is related to enhancement of the occipital-temporal N1. As in spatial attention, proactive control appears to enhance cortical excitability and facilitate discrimination performance in tasks requiring nonspatial, feature-based attention, even in the absence of competing stimulus features.

  11. Flood-inundation maps for the DuPage River from Plainfield to Shorewood, Illinois, 2013

    USGS Publications Warehouse

    Murphy, Elizabeth A.; Sharpe, Jennifer B.

    2013-01-01

    Digital flood-inundation maps for a 15.5-mi reach of the DuPage River from Plainfield to Shorewood, Illinois, were created by the U.S. Geological Survey (USGS) in cooperation with the Will County Stormwater Management Planning Committee. The inundation maps, which can be accessed through the USGS Flood Inundation Mapping Science Web site at http://water.usgs.gov/osw/flood_inundation/ depict estimates of the areal extent of flooding corresponding to selected water levels (gage heights or stages) at the USGS streamgage at DuPage River at Shorewood, Illinois (sta. no. 05540500). Current conditions at the USGS streamgage may be obtained on the Internet at http://waterdata.usgs.gov/usa/nwis/uv?05540500. In addition, the information has been provided to the National Weather Service (NWS) for incorporation into their Advanced Hydrologic Prediction Service (AHPS) flood warning system (http://water.weather.gov/ahps/). The NWS forecasts flood hydrographs at many places that are often colocated with USGS streamgages. The NWS-forecasted peak-stage information, also shown on the DuPage River at Shorewood inundation Web site, may be used in conjunction with the maps developed in this study to show predicted areas of flood inundation. In this study, flood profiles were computed for the stream reach by means of a one-dimensional step-backwater model. The hydraulic model was then used to determine nine water-surface profiles for flood stages at 1-ft intervals referenced to the streamgage datum and ranging from NWS Action stage of 6 ft to the historic crest of 14.0 ft. The simulated water-surface profiles were then combined with a Digital Elevation Model (DEM) (derived from Light Detection And Ranging (LiDAR) data) by using a Geographic Information System (GIS) in order to delineate the area flooded at each water level. These maps, along with information on the Internet regarding current gage height from USGS streamgages and forecasted stream stages from the NWS, provide emergency

  12. Colleges Get Free Web Pages but with a Catch: Advertising.

    ERIC Educational Resources Information Center

    Blumenstyk, Goldie

    1999-01-01

    Striving to streamline student services and improve electronic communication, colleges and universities are signing on with companies that offer sophisticated World Wide Web sites through which students can accomplish basic administrative functions and receive information. The sites are often free of charge but also feature advertising messages…

  13. The United States Today: An Atlas of Reproducible Pages.

    ERIC Educational Resources Information Center

    World Eagle, Inc., Wellesley, MA.

    Black and white maps, graphs and tables that may be reproduced are presented in this volume focusing on the United States. Some of the features of the United States depicted are: size, population, agriculture and resources, manufactures, trade, citizenship, employment, income, poverty, the federal budget, energy, health, education, crime, and the…

  14. Colonic ornithine decarboxylase in inflammatory bowel disease: ileorectal activity gradient, guanosine triphosphate stimulation, and association with epithelial regeneration but not the degree of inflammation and clinical features.

    PubMed

    Allgayer, Hubert; Roisch, Ulla; Zehnter, Elmar; Ziegenhagen, Dieter J; Dienes, Hans P; Kruis, Wolfgang

    2007-01-01

    The role of colonic mucosal ornithine decarboxylase (ODC) in inflammatory bowel disease (IBD) remains controversial. This study assessed mucosal ODC activity in IBD patients segment by segment with regard to patient characteristics, disease activity/duration, medication, degree of mucosal inflammation, and presence/absence of epithelial regeneration and guanosine triphosphate (GTP) stimulation. Mucosal ODC activity was determined in biopsy specimens from the terminal ileum, cecum/ascending, transverse, and descending colon, and the sigmoid/rectum of 35 patients with IBD (18 with Crohn's disease, 17 with ulcerative colitis) and 29 controls, using the amount of 14CO2 liberated from (carboxyl-14C)ornithine hydrochloride. GTP-stimulatable activity was expressed as the ratio of ODC activity in the presence and absence of GTP (70 micromol/L). Mucosal inflammation was assessed endoscopically/microscopically with previously described criteria. Presence/absence of mucosal regeneration also was determined by predefined criteria. Mucosal ODC-activity did not significantly differ in IBD patients and controls. There was a 4.4-fold activity gradient from the ileum to the rectum. Mucosal ODC activity was significantly higher in areas with epithelial regeneration compared to those without regeneration, and was stimulated by GTP by a factor of 1.42 in Crohn's disease and 1.19 in ulcerative colitis patients compared to controls (p < 0.004). On the other hand, there was no significant association/relationship of mucosal ODC activity with disease activity/duration and the endoscopic/histologic degree of mucosal inflammation. The observation of unchanged mucosal ODC activity in patients with IBD and the absence of a significant relationship with clinical and endoscopic/histologic disease characteristics speaks against a major role of ODC in IBD as a major disease marker. The role of the ileorectal gradient, the enhanced activity in areas with epithelial regeneration, and the GTP

  15. Basic features of low-temperature plasma formation in the course of composite coating synthesis at the active faces of complex contoured hard tools

    NASA Astrophysics Data System (ADS)

    Brzhozovsky, B. M.; Zimnyakov, D. A.; Zinina, E. P.; Martynov, V. V.; Pleshakova, E. S.; Yuvchenko, S. A.

    2016-04-01

    Basic features of combined-discharge low-temperature plasma formation around the surfaces of complex-contoured metal units are considered. It is shown that it makes the possibilities for synthesis of hardened high-durable coatings of hard tools appropriate for material processing in extreme load-temperature conditions. Experimental study of the coating formation was carried out in combination with the analysis of emission spectra of a low-temperature plasma cloud. Some practical examples of the coating applications are presented.

  16. National Institute of Environmental Health Sciences Kids' Pages

    MedlinePlus

    ... Environment & Health Healthy Living Pollution Reduce, Reuse, Recycle Science – How It Works The Natural World Games Brainteasers Puzzles Riddles Songs Activities Be a Scientist Coloring Science Experiments Stories Lessons Topics Games Activities Lessons MENU ...

  17. 49 CFR 1312.9 - Statement of tariff application and other title page requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... BY OR WITH A WATER CARRIER IN NONCONTIGUOUS DOMESTIC TRADE § 1312.9 Statement of tariff application... shall lead with a title page. The title page of each tariff or supplement shall include the expiration..., mode of serving carrier(s), type of rates, and description of tariff content. EXAMPLES: (a) Local...

  18. The Situated Aspect of Creativity in Communicative Events: How Do Children Design Web Pages Together?

    ERIC Educational Resources Information Center

    Fernandez-Cardenas, Juan Manuel

    2008-01-01

    This paper looks at the collaborative construction of web pages in History by a Year-4 group of children in a primary school in the UK. The aim of this paper is to find out: (a) How did children interpret their involvement in this literacy practice? (b) How the construction of web pages was interactionally accomplished? and (c) How can creativity…

  19. Design of binary data page with a phase mask for high-density holographic recording

    NASA Astrophysics Data System (ADS)

    Barada, Daisuke; Kawata, Shigeo; Yatagai, Toyohiko

    2015-08-01

    This paper proposes a method to increase the recording density of binary data pages in holographic memory. The recording density is increased by decreasing the rectangular aperture size on a Fourier plane. To extract the original data page from the low quality image, a four-step phase mask is designed. The principle of the proposed method is numerically verified.

  20. Virtuous, Virtual Access: Making Web Pages Accessible to People with Disabilities.

    ERIC Educational Resources Information Center

    Kautzman, Amy M.

    1998-01-01

    Describes tools that make the Web more accessible for people with disabilities and lists some of the basic rules for designing a page layout, focusing on HTML, color, buttons, images, links, image map, forms, columns and frames, applets and plug-ins. Discusses how to evaluate the Web page. (AEF)

  1. Determination of the Subunit Molecular Mass and Composition of Alcohol Dehydrogenase by SDS-PAGE

    ERIC Educational Resources Information Center

    Nash, Barbara T.

    2007-01-01

    SDS-PAGE is a simple, rapid technique that has many uses in biochemistry and is readily adaptable to the undergraduate laboratory. It is, however, a technique prone to several types of procedural pitfalls. This article describes the use of SDS-PAGE to determine the subunit molecular mass and composition of yeast alcohol dehydrogenase employing…

  2. Teaching E-Commerce Web Page Evaluation and Design: A Pilot Study Using Tourism Destination Sites

    ERIC Educational Resources Information Center

    Susser, Bernard; Ariga, Taeko

    2006-01-01

    This study explores a teaching method for improving business students' skills in e-commerce page evaluation and making Web design majors aware of business content issues through cooperative learning. Two groups of female students at a Japanese university studying either tourism or Web page design were assigned tasks that required cooperation to…

  3. Web Page Design and Graphic Use of Three U.S. Newspapers.

    ERIC Educational Resources Information Center

    Li, Xigen

    1998-01-01

    Contributes to scholarship on journalism and new technology by exploring approaches to Web page design and graphic use in three Internet newspapers. Explores how they demonstrate a change from the convention of newspaper publishing to the new media age, and how Web page design and graphic use reflect interconnectedness and a shift of control from…

  4. A New Era of Search Engines: Not Just Web Pages Anymore.

    ERIC Educational Resources Information Center

    Hock, Ran

    2002-01-01

    Discusses various types of information that can be retrieved from the Web via search engines. Highlights include Web pages; time frames, including historical coverage and currentness; text pages in formats other than HTML; directory sites; news articles; discussion groups; images; and audio and video. (LRW)

  5. Future Trends in Children's Web Pages: Probing Hidden Biases for Information Quality

    ERIC Educational Resources Information Center

    Kurubacak, Gulsun

    2007-01-01

    As global digital communication continues to flourish, Children's Web pages become more critical for children to realize not only the surface but also breadth and deeper meanings in presenting these milieus. These pages not only are very diverse and complex but also enable intense communication across social, cultural and political restrictions…

  6. Future Trends in Chlldren's Web Pages: Probing Hidden Biases for Information Quality

    ERIC Educational Resources Information Center

    Kurubacak, Gulsun

    2007-01-01

    As global digital communication continues to flourish, Children's Web pages become more critical for children to realize not only the surface but also breadth and deeper meanings in presenting these milieus. These pages not only are very diverse and complex but also enable intense communication across social, cultural and political restrictions…

  7. Social Responsibility and Corporate Web Pages: Self-Presentation or Agenda-Setting?

    ERIC Educational Resources Information Center

    Esrock, Stuart L.; Leichty, Greg B.

    1998-01-01

    Examines how corporate entities use the Web to present themselves as socially responsible citizens and to advance policy positions. Samples randomly "Fortune 500" companies, revealing that, although 90% had Web pages and 82% of the sites addressed a corporate social responsibility issue, few corporations used their pages to monitor public opinion…

  8. Measuring the Mean Web Page Size and Its Compression To Limit Latency and Improve Download Time.

    ERIC Educational Resources Information Center

    Destounis, P.; Garofalakis, J.; Kappos, P.; Tzimas, J.

    2001-01-01

    Presents a case study that calculates the reduction of the time needed for a Web page to be fully downloaded and delivered to the user. Topics include bandwidth; HTTP; data transfer; algorithms for compression and decompression of Web pages; and reducing the size of hypertext data. (Author/LRW)

  9. World of Our Mothers: The Women's Page of the "Jewish Daily Forward" in 1919.

    ERIC Educational Resources Information Center

    Seller, Maxine Schwartz

    In 1919 the "Jewish Daily Forward" published in New York City was the leading Yiddish language newspaper in the world. This analysis explores how the themes of socialism, feminism, and Americanization were defined and developed on the women's pages, and what advice and information the page transmitted to its immigrant readers about each theme.…

  10. Exploring Cultural Variation in Eye Movements on a Web Page between Americans and Koreans

    ERIC Educational Resources Information Center

    Yang, Changwoo

    2009-01-01

    This study explored differences in eye movement on a Web page between members of two different cultures to provide insight and guidelines for implementation of global Web site development. More specifically, the research examines whether differences of eye movement exist between the two cultures (American vs. Korean) when viewing a Web page, and…

  11. ARL Physics Web Pages: An Evaluation by Established, Transitional and Emerging Benchmarks.

    ERIC Educational Resources Information Center

    Duffy, Jane C.

    2002-01-01

    Provides an overview of characteristics among Association of Research Libraries (ARL) physics Web pages. Examines current academic Web literature and from that develops six benchmarks to measure physics Web pages: ease of navigation; logic of presentation; representation of all forms of information; engagement of the discipline; interactivity of…

  12. Web Page Change and Persistence-A Four-Year Longitudinal Study.

    ERIC Educational Resources Information Center

    Koehler, Wallace

    2002-01-01

    Discussion of changes in the topography of the Web focuses on changes to an existing set of Web documents over a four-year period. Highlights include the life cycle of Web objects; changes to Web objects; measures of change; Web page demise; and Web page changes, including hypertext links, content change, and structural change. (LRW)

  13. 78 FR 44424 - Revisions to Page 700 of FERC Form No. 6

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-24

    ... rate base, and income taxes reported on Page 700. \\8\\ Revisions to Page 700 of FERC Form No. 6, 77 FR... Stats. & Regs. ] 32,692 at P 9 n.13 (citing ARCO Pipe Line Co., Opinion No. 351-A, 53 FERC ] 61,398...

  14. Twin-page storage management for rapid transaction-undo recovery

    NASA Technical Reports Server (NTRS)

    Wu, Kun-Lung; Fuchs, W. Kent

    1990-01-01

    This paper presents and evaluates a new twin-page disk-storage management scheme for rapid database transaction-undo recovery. In contrast to previous twin-page schemes, the present approach uses static page mapping and allows dirty pages in the main memory to be written, at any instant, onto disk without the requirement of undo logging. No explicit undo is required when a transaction is aborted. Transaction undo is implicitly performed by not subsequently fetching from disk the invalid pages updated by the aborted transaction. Performance in terms of disk I/O and CPU overhead for transaction-undo recovery is analyzed and compared with a previous approach TWIST. It is shown that the scheme achieves rapid transaction-undo recovery without degrading average system performance for various workloads, and that the scheme is well suited for applications with a large number of updates and frequent transaction aborts.

  15. Science on the Web: Secondary School Students' Navigation Patterns and Preferred Pages' Characteristics

    NASA Astrophysics Data System (ADS)

    Dimopoulos, Kostas; Asimakopoulos, Apostolos

    2010-06-01

    This study aims to explore navigation patterns and preferred pages' characteristics of ten secondary school students' searching the web for information about cloning. The students navigated the Web for as long as they wished in a context of minimum support of teaching staff. Their navigation patterns were analyzed using audit trail data software. The characteristics of their preferred Web pages were also analyzed using a scheme of analysis largely based on socio-linguistics and socio-semiotics approaches. Two distinct groups of students could be discerned. The first consisted of more competent students, who during their navigation visited fewer relevant pages, however of higher credibility and more specialized content. The second group consists of weaker students, who visited more pages, mainly of lower credibility and rather popularized content. Implications for designing educational web pages and teaching are discussed.

  16. PageRank, HITS and a unified framework for link analysis

    SciTech Connect

    Ding, Chris; He, Xiaofeng; Husbands, Parry; Zha, Hongyuan; Simon, Horst

    2001-10-01

    Two popular webpage ranking algorithms are HITS and PageRank. HITS emphasizes mutual reinforcement between authority and hub webpages, while PageRank emphasizes hyperlink weight normalization and web surfing based on random walk models. We systematically generalize/combine these concepts into a unified framework. The ranking framework contains a large algorithm space; HITS and PageRank are two extreme ends in this space. We study several normalized ranking algorithms which are intermediate between HITS and PageRank, and obtain closed-form solutions. We show that, to first order approximation, all ranking algorithms in this framework, including PageRank and HITS, lead to same ranking which is highly correlated with ranking by indegree. These results support the notion that in web resource ranking indegree and outdegree are of fundamental importance. Rankings of webgraphs of different sizes and queries are presented to illustrate our analysis.

  17. The Technology of Extracting Content Information from Web Page Based on DOM Tree

    NASA Astrophysics Data System (ADS)

    Yuan, Dingrong; Mo, Zhuoying; Xie, Bing; Xie, Yangcai

    There are huge amounts of information on Web pages, which includes content information and other useless information, such as navigation, advertisement and flash of animation etc. Reducing the toils of Web users, we estabished a thechnique to extract the content information from web page. Fristly, we analyzed the semantic of web documents by V8 engine of Google and parsed the web document into DOM tree. And then, traversed the DOM tree, pruned the DOM tree in the light of the characteristic of Web page's edit language. Finally, we extracted the content information from Web page. Theoretics and experiments showed that the technique could simplify the web page, present the content information to web users and supply clean data for applicable area, such as retrieval, KDD and DM from web.

  18. Adding a visualization feature to web search engines: it's time.

    PubMed

    Wong, Pak Chung

    2008-01-01

    It's widely recognized that all Web search engines today are almost identical in presentation layout and behavior. In fact, the same presentation approach has been applied to depicting search engine results pages (SERPs) since the first Web search engine launched in 1993. In this Visualization Viewpoints article, I propose to add a visualization feature to Web search engines and suggest that the new addition can improve search engines' performance and capabilities, which in turn lead to better Web search technology.

  19. Common Features of Neural Activity during Singing and Sleep Periods in a Basal Ganglia Nucleus Critical for Vocal Learning in a Juvenile Songbird

    PubMed Central

    Yanagihara, Shin; Hessler, Neal A.

    2011-01-01

    Reactivations of waking experiences during sleep have been considered fundamental neural processes for memory consolidation. In songbirds, evidence suggests the importance of sleep-related neuronal activity in song system motor pathway nuclei for both juvenile vocal learning and maintenance of adult song. Like those in singing motor nuclei, neurons in the basal ganglia nucleus Area X, part of the basal ganglia-thalamocortical circuit essential for vocal plasticity, exhibit singing-related activity. It is unclear, however, whether Area X neurons show any distinctive spiking activity during sleep similar to that during singing. Here we demonstrate that, during sleep, Area X pallidal neurons exhibit phasic spiking activity, which shares some firing properties with activity during singing. Shorter interspike intervals that almost exclusively occurred during singing in awake periods were also observed during sleep. The level of firing variability was consistently higher during singing and sleep than during awake non-singing states. Moreover, deceleration of firing rate, which is considered to be an important firing property for transmitting signals from Area X to the thalamic nucleus DLM, was observed mainly during sleep as well as during singing. These results suggest that songbird basal ganglia circuitry may be involved in the off-line processing potentially critical for vocal learning during sensorimotor learning phase. PMID:21991379

  20. China English: Its Distinctive Features

    ERIC Educational Resources Information Center

    Yang, Wei-dong; Dai, Wei-ping

    2011-01-01

    This paper attempts to expound that China English boasting its own distinctive features on the levels of phonology, words, sentences and discourse has been playing an irreplaceable role in intercultural activities, though still in its infancy and in the process of developing and perfecting itself, and it now makes every effort to move towards…