Science.gov

Sample records for activity schedule milestones

  1. AVLIS production plant project schedule and milestones

    SciTech Connect

    Not Available

    1984-11-15

    An AVLIS Production Plant Deployment Schedule for the engineering, procurement, and construction for both the Initial Increment of Production and the fully Activated Plant, has been developed by the project team consisting of Lawrence Livermore National Laboratory, Martin Marietta Energy Systems, Inc. with architect-engineer support from Bechtel National, Inc., Stone and Webster Engineering Corporation, and Westinghouse Corporation. The initial deployment phase consists of six separators modules and the three laser power amplifier modules consistent with the FY84 reference design with a name plate capacity of 5 million separative work units/yr followed by a full plant activation to approximately 13 million separative work units/yr. The AVLIS Production Plant project team's strategy for deployment schedule analysis focused on three schedule options: engineering limited schedule; authorization limited schedule; and funding limited project schedule. The three deployment schedule options developed by AVLIS project team have been classified in ranges such as an optimistic, rapid/moderate, or moderate/pessimistic based on the probability of meeting the individual schedule option's major milestones or program objectives of enriching uranium by the AVLIS process in an effective cost and schedule manner. 47 figures, 7 tables.

  2. Polynomial optimization techniques for activity scheduling. Optimization based prototype scheduler

    NASA Technical Reports Server (NTRS)

    Reddy, Surender

    1991-01-01

    Polynomial optimization techniques for activity scheduling (optimization based prototype scheduler) are presented in the form of the viewgraphs. The following subject areas are covered: agenda; need and viability of polynomial time techniques for SNC (Space Network Control); an intrinsic characteristic of SN scheduling problem; expected characteristics of the schedule; optimization based scheduling approach; single resource algorithms; decomposition of multiple resource problems; prototype capabilities, characteristics, and test results; computational characteristics; some features of prototyped algorithms; and some related GSFC references.

  3. Mission and science activity scheduling language

    NASA Technical Reports Server (NTRS)

    Hull, Larry G.

    1993-01-01

    To support the distributed and complex operational scheduling required for future National Aeronautics and Space Administration (NASA) missions, a formal, textual language, the Scheduling Applications Interface Language (SAIL), has been developed. Increased geographic dispersion of investigators is leading to distributed mission and science activity planning, scheduling, and operations. SAIL is an innovation which supports the effective and efficient communication of scheduling information among physically dispersed applications in distributed scheduling environments. SAIL offers a clear, concise, unambiguous expression of scheduling information in a readable, hardware independent format. The language concept, syntax, and semantics incorporate language features found useful during five years of research and prototyping with scheduling languages in physically distributed environments. SAIL allows concise specification of mission and science activity plans in a format which promotes repetition and reuse.

  4. Schedule-induced locomotor activity in humans.

    PubMed

    Muller, P G; Crow, R E; Cheney, C D

    1979-01-01

    In two experiments, humans received tokens either on a fixed-interval schedule for plunger pulling or various response-nondependent fixed-time schedules ranging from 16 to 140 seconds. Locomotor activity such as walking, shifting weight, or pacing was recorded in quarters of the interreinforcement interval to examine the induced characteristics of that behavior in humans. While performance was variable, several characteristics were present that have counterparts in experiments with nonhumans during periodic schedules of food reinforcement: (a) first quarter rates, and sometimes overall rates, of locomotor activity were greater during intervals that terminated in a visual stimulus and token delivery than those without: (b) overall rates of locomotor activity were greater during fixed-time 16-second schedules than during fixed-time 80- or 140-second schedules; (c) rates of locomotor activity decreased during the interreinforcement intervals; (d) locomotor activity was induced by response-dependent and response-nondependent token delivery. These results showed that the rate and temporal pattern of locomotor activity can be schedule-induced in humans. PMID:429959

  5. "Missing Milestones."

    ERIC Educational Resources Information Center

    Afzal, Nadeem A.; Martin, Diana L.; Atkinson, Patricia I.

    2001-01-01

    Examined the development of seven infants with "missing milestones" in motor development. Found that three children had normal development, three developed global developmental delay, and one was diagnosed with multiple cavernous haemangiomata in the brain. Suggested that missing milestones can be a benign variation of normal motor development or…

  6. Exact milestoning

    SciTech Connect

    Bello-Rivas, Juan M.; Elber, Ron

    2015-03-07

    A new theory and an exact computer algorithm for calculating kinetics and thermodynamic properties of a particle system are described. The algorithm avoids trapping in metastable states, which are typical challenges for Molecular Dynamics (MD) simulations on rough energy landscapes. It is based on the division of the full space into Voronoi cells. Prior knowledge or coarse sampling of space points provides the centers of the Voronoi cells. Short time trajectories are computed between the boundaries of the cells that we call milestones and are used to determine fluxes at the milestones. The flux function, an essential component of the new theory, provides a complete description of the statistical mechanics of the system at the resolution of the milestones. We illustrate the accuracy and efficiency of the exact Milestoning approach by comparing numerical results obtained on a model system using exact Milestoning with the results of long trajectories and with a solution of the corresponding Fokker-Planck equation. The theory uses an equation that resembles the approximate Milestoning method that was introduced in 2004 [A. K. Faradjian and R. Elber, J. Chem. Phys. 120(23), 10880-10889 (2004)]. However, the current formulation is exact and is still significantly more efficient than straightforward MD simulations on the system studied.

  7. A planning language for activity scheduling

    NASA Technical Reports Server (NTRS)

    Zoch, David R.; Lavallee, David; Weinstein, Stuart; Tong, G. Michael

    1991-01-01

    Mission planning and scheduling of spacecraft operations are becoming more complex at NASA. Described here are a mission planning process; a robust, flexible planning language for spacecraft and payload operations; and a software scheduling system that generates schedules based on planning language inputs. The mission planning process often involves many people and organizations. Consequently, a planning language is needed to facilitate communication, to provide a standard interface, and to represent flexible requirements. The software scheduling system interprets the planning language and uses the resource, time duration, constraint, and alternative plan flexibilities to resolve scheduling conflicts.

  8. Developmental Milestones.

    PubMed

    Scharf, Rebecca J; Scharf, Graham J; Stroustrup, Annemarie

    2016-01-01

    • On the basis of observational studies (level C), preterm birth is a leading cause of neurodevelopmental disabilities in children, and the degree of neurodevelopmental disability is inversely correlated with gestational age at birth. When comparing performance of preterm children to developmental norms, “corrected age” or age from due date rather than birth date should be used for the first 24 to 36 months. • On the basis of observational studies (level C), clinicians should pay specific attention to sensory function in children born preterm because the incidence of visual and hearing impairments is higher in preterm than term children. Due to the elevated risk of cognitive and behavioral disabilities, clinicians caring for children born preterm should be vigilant when performing developmental assessments to improve outcomes. • On the basis of observational studies (level C), early identification of developmental delays allows for referral to therapeutic services, and children referred for early intervention are more likely to make gains in developmental milestones. PMID:26729779

  9. Preemie Milestones

    MedlinePlus

    ... should be doing at this age. At 2 Months (8 Weeks) Motor Moves hands and legs actively ... interactions with mother or primary caregiver At 4 Months (16 Weeks) Motor Brings hands together, or to ...

  10. Entrustable professional activities and curricular milestones for fellowship training in pulmonary and critical care medicine: report of a multisociety working group.

    PubMed

    Fessler, Henry E; Addrizzo-Harris, Doreen; Beck, James M; Buckley, John D; Pastores, Stephen M; Piquette, Craig A; Rowley, James A; Spevetz, Antoinette

    2014-09-01

    This article describes the curricular milestones and entrustable professional activities for trainees in pulmonary, critical care, or combined fellowship programs. Under the Next Accreditation System of the Accreditation Council for Graduate Medical Education (ACGME), curricular milestones compose the curriculum or learning objectives for training in these fields. Entrustable professional activities represent the outcomes of training, the activities that society and professional peers can expect fellowship graduates to be able to perform unsupervised. These curricular milestones and entrustable professional activities are the products of a consensus process from a multidisciplinary committee of medical educators representing the American College of Chest Physicians (CHEST), the American Thoracic Society, the Society of Critical Care Medicine, and the Association of Pulmonary and Critical Care Medicine Program Directors. After consensus was achieved using the Delphi process, the document was revised with input from the sponsoring societies and program directors. The resulting lists can serve as a roadmap and destination for trainees, program directors, and educators. Together with the reporting milestones, they will help mark trainees' progress in the mastery of the six ACGME core competencies of graduate medical education. PMID:24945874

  11. Focus of attention in an activity-based scheduler

    NASA Technical Reports Server (NTRS)

    Sadeh, Norman; Fox, Mark S.

    1989-01-01

    Earlier research in job shop scheduling has demonstrated the advantages of opportunistically combining order-based and resource-based scheduling techniques. An even more flexible approach is investigated where each activity is considered a decision point by itself. Heuristics to opportunistically select the next decision point on which to focus attention (i.e., variable ordering heuristics) and the next decision to be tried at this point (i.e., value ordering heuristics) are described that probabilistically account for both activity precedence and resource requirement interactions. Preliminary experimental results indicate that the variable ordering heuristic greatly increases search efficiency. While least constraining value ordering heuristics have been advocated in the literature, the experimental results suggest that other value ordering heuristics combined with our variable-ordering heuristic can produce much better schedules without significantly increasing search.

  12. Developmental milestones record - 3 years

    MedlinePlus

    Normal childhood growth milestones - 3 years; Growth milestones for children - 3 years; Childhood growth milestones - 3 years ... milestones are typical for children in their third year of life. Always keep in mind that some ...

  13. Developmental milestones record - 5 years

    MedlinePlus

    Normal childhood growth milestones - 5 years; Childhood growth milestones - 5 years; Growth milestones for children - 5 years ... Physical and motor skill milestones for a typical 5-year-old child include: Gains about 4 - 5 ...

  14. Developmental milestones record - 9 months

    MedlinePlus

    Growth milestones for children - 9 months; Childhood growth milestones - 9 months; Normal childhood growth milestones - 9 months ... provider. PHYSICAL CHARACTERISTICS AND MOTOR SKILLS A 9-month-old has usually reached the following milestones: Gains ...

  15. Talking Picture Schedules: Embedding Video Models into Visual Activity Schedules to Increase Independence for Students with ASD

    ERIC Educational Resources Information Center

    Spriggs, Amy D.; Knight, Victoria; Sherrow, Lauren

    2015-01-01

    Studies examining video modeling and visual activity schedules independent of one another have been shown to be effective in teaching skills for students with autism, but there is little research about the effectiveness of combining the two methods. Use of visual activity schedules with embedded video models via an iPad application was…

  16. Comparing Pictorial and Video Modeling Activity Schedules during Transitions for Students with Autism Spectrum Disorders

    ERIC Educational Resources Information Center

    Cihak, David F.

    2011-01-01

    This study evaluated the differential effects of two different visual schedule strategies. In the context of an alternating treatments design, static-picture schedules were compared to video based activity schedules as supports for three middle school aged students with autism. Students used the visual schedules to transition between activities in…

  17. Comparing Pictorial and Video-Modeling Activity Schedules during Transitions for Students with Autism Spectrum Disorders

    ERIC Educational Resources Information Center

    Cihak, David F.; Ayres, Kevin M.

    2010-01-01

    This study evaluated the differential effects of two different visual schedule strategies. In the context of an alternating treatments design, static-picture schedules were compared to video based activity schedules as supports for three middle school aged students with autism. Students used the visual schedules to transition between activities in…

  18. Entrustable professional activities and curricular milestones for fellowship training in pulmonary and critical care medicine: executive summary from the Multi-Society Working Group.

    PubMed

    Fessler, Henry E; Addrizzo-Harris, Doreen; Beck, James M; Buckley, John D; Pastores, Stephen M; Piquette, Craig A; Rowley, James A; Spevetz, Antoinette

    2014-10-01

    Assessment of graduate medical trainee progress via the accomplishment of competency milestones is an important element of the Next Accreditation System of the Accreditation Council for Graduate Medical Education. This article summarizes the findings of a multisociety working group that was tasked with creating the entrustable professional activities and curricular milestones for fellowship training in pulmonary medicine, critical care medicine, and combined programs. Using the Delphi process, experienced medical educators from the American College of Chest Physicians, American Thoracic Society, Society of Critical Care Medicine, and Association of Pulmonary and Critical Care Medicine Program Directors reached consensus on the detailed curricular content and expected skill set of graduates of these programs. These are now available to trainees and program directors for the purposes of curriculum design, review, and trainee assessment. PMID:25226119

  19. The integrated scheduling system: A case study in project management

    NASA Technical Reports Server (NTRS)

    Bishop, Peter C.; Learned, David B.; Yoes, Cissy A.

    1989-01-01

    A prototype project management system was developed for the Level III Project Office for the Space Station Freedom. The main goal was to establish a framework for the Space Station Project Office whereby Project and Office Managers can jointly establish and review scheduled milestones and activities. The objective was to assist office managers in communicating their objectives, milestones, schedules, and other project information more effectively and efficiently. Consideration of sophisticated project management systems was included, but each of the systems had limitations in meeting the stated objectives.

  20. Developmental milestones record - 2 years

    MedlinePlus

    Growth milestones for children - 2 years; Normal childhood growth milestones - 2 years; Childhood growth milestones - 2 years ... cause for concern if not seen by 2 years.) Can run with better coordination . (May still have ...

  1. Developmental milestones record - 4 years

    MedlinePlus

    Normal childhood growth milestones - 4 years; Growth milestones for children - 4 years; Childhood growth milestones - 4 years ... care provider. PHYSICAL AND MOTOR During the fourth year, a child typically: Gains weight at the rate ...

  2. Developmental milestones record - 4 months

    MedlinePlus

    Normal childhood growth milestones - 4 months; Childhood growth milestones - 4 months; Growth milestones for children - 4 months ... provider. PHYSICAL AND MOTOR SKILLS The typical 4-month-old baby should: Slow in weight gain to ...

  3. Developmental milestones record - 18 months

    MedlinePlus

    Growth milestones for children - 18 months; Normal childhood growth milestones - 18 months; Childhood growth milestones - 18 months ... PHYSICAL AND MOTOR SKILL MARKERS The typical 18-month-old: Has a closed soft spot on the ...

  4. Developmental milestones record - 6 months

    MedlinePlus

    Normal childhood growth milestones - 6 months; Childhood growth milestones - 6 months; Growth milestones for children - 6 months ... the weight on hands (often occurs by 4 months) Able to pick up a dropped object Able ...

  5. Developmental milestones record - 12 months

    MedlinePlus

    Normal childhood growth milestones - 12 months; Growth milestones for children - 12 months; Childhood growth milestones - 12 months ... care provider. PHYSICAL AND MOTOR SKILLS A 12-month-old child is expected to: Be 3 times ...

  6. A suggested emergency medicine boot camp curriculum for medical students based on the mapping of Core Entrustable Professional Activities to Emergency Medicine Level 1 milestones

    PubMed Central

    Lamba, Sangeeta; Wilson, Bryan; Natal, Brenda; Nagurka, Roxanne; Anana, Michael; Sule, Harsh

    2016-01-01

    Background An increasing number of students rank Emergency Medicine (EM) as a top specialty choice, requiring medical schools to provide adequate exposure to EM. The Core Entrustable Professional Activities (EPAs) for Entering Residency by the Association of American Medical Colleges combined with the Milestone Project for EM residency training has attempted to standardize the undergraduate and graduate medical education goals. However, it remains unclear as to how the EPAs correlate to the milestones, and who owns the process of ensuring that an entering EM resident has competency at a certain minimum level. Recent trends establishing specialty-specific boot camps prepare students for residency and address the variability of skills of students coming from different medical schools. Objective Our project’s goal was therefore to perform a needs assessment to inform the design of an EM boot camp curriculum. Toward this goal, we 1) mapped the core EPAs for graduating medical students to the EM residency Level 1 milestones in order to identify the possible gaps/needs and 2) conducted a pilot procedure workshop that was designed to address some of the identified gaps/needs in procedural skills. Methods In order to inform the curriculum of an EM boot camp, we used a systematic approach to 1) identify gaps between the EPAs and EM milestones (Level 1) and 2) determine what essential and supplemental competencies/skills an incoming EM resident should ideally possess. We then piloted a 1-day, three-station advanced ABCs procedure workshop based on the identified needs. A pre-workshop test and survey assessed knowledge, preparedness, confidence, and perceived competence. A post-workshop survey evaluated the program, and a posttest combined with psychomotor skills test using three simulation cases assessed students’ skills. Results Students (n=9) reported increased confidence in the following procedures: intubation (1.5–2.1), thoracostomy (1.1–1.9), and central venous

  7. Talking Picture Schedules: Embedding Video Models into Visual Activity Schedules to Increase Independence for Students with ASD.

    PubMed

    Spriggs, Amy D; Knight, Victoria; Sherrow, Lauren

    2015-12-01

    Studies examining video modeling and visual activity schedules independent of one another have been shown to be effective in teaching skills for students with autism, but there is little research about the effectiveness of combining the two methods. Use of visual activity schedules with embedded video models via an iPad application was investigated to determine if high school students with autism could transition within and between novel activities (e.g., writing paragraphs, setting a table, data entry) using a multiple probe across participants design. Findings indicate youth with autism were able to independently transition within and between tasks. Students exhibited high rates of generalization to the static visual activity schedules and novel task exemplars after the embedded video model was removed. PMID:25413145

  8. Milestones in Rotorcraft Aeromechanics

    NASA Technical Reports Server (NTRS)

    Johnson, Wayne

    2011-01-01

    The subject of this paper is milestones in rotorcraft aeromechanics. Aeromechanics covers much of what the engineer needs: performance, loads, vibration, stability, flight dynamics, noise. These topics cover many of the key performance attributes, and many of the often-encountered problems in rotorcraft designs. A milestone is a critical achievement, a turning point, an event marking a significant change or stage in development. The milestones identified and discussed include the beginnings of aeromechanics with autogyro analysis, ground resonance, aeromechanics books, unsteady aerodynamics and airloads, nonuniform inflow and wakes, beams and dynamics, comprehensive analysis, computational fluid dynamics, and rotor airloads tests. The focus on milestones limits the scope of the history, but allows the author to acknowledge his choices for key steps in the development of the science and engineering of rotorcraft.

  9. Developmental milestones record

    MedlinePlus

    ... foot Rides tricycle well Starts school Understands size concepts Understands time concepts School-age child -- 6 to 12 years Begins ... and recognition is of vital importance Understands abstract concepts ... topics include: Developmental milestones record - 2 months ...

  10. Found in transition: applying milestones to three unique discharge curricula

    PubMed Central

    Todd, Christine Y.; Walsh, Meghan M.

    2015-01-01

    Introduction. A safe and effective transition from hospital to post-acute care is a complex and important physician competency. Milestones and Entrustable Professional Activities (EPA) form the new educational rubric in Graduate Medical Education Training. “A safe and effective discharge from the hospital” is an EPA ripe for educational innovation. Methods. The authors collaborated in a qualitative process called mapping to define 22 of 142 Internal Medicine (IM) curricular milestones related to the transition of care. Fifty-five participant units at an Association for Program Directors in Internal Medicine (APDIM) workshop prioritized the milestones, using a validated ranking process called Q-sort. We analyzed the Q-sort results, which rank the milestones in order of priority. We then applied this ranking to three innovative models of training IM residents in the transitions of care: Simulation (S), Discharge Clinic Feedback (DCF) and TRACER (T). Results. We collected 55 Q-sort rankings from particpants at the APDIM workshop. We then identified which milestones are a focus of the three innovative models of training in the transition of care: Simulation = 5 of 22 milestones, Discharge Clinic Feedback = 9 of 22 milestones, and TRACER = 7 of 22 milestones. Milestones identified in each innovation related to one of the top 8 prioritized milestones 75% of the time; thus, more frequently than the milestones with lower priority. Two milestones are shared by all three curricula: Utilize patient-centered education and Ensure succinct written communication. Two other milestones are shared by two curricula: Manage and coordinate care transitions across multiple delivery systems and Customize care in the context of the patient’s preferences. If you combine the three innovations, all of the top 8 milestones are included. Discussion. The milestones give us a context to share individual innovations and to compare and contrast using a standardized frame. We demonstrate that

  11. Found in transition: applying milestones to three unique discharge curricula.

    PubMed

    Meade, Lauren B; Todd, Christine Y; Walsh, Meghan M

    2015-01-01

    Introduction. A safe and effective transition from hospital to post-acute care is a complex and important physician competency. Milestones and Entrustable Professional Activities (EPA) form the new educational rubric in Graduate Medical Education Training. "A safe and effective discharge from the hospital" is an EPA ripe for educational innovation. Methods. The authors collaborated in a qualitative process called mapping to define 22 of 142 Internal Medicine (IM) curricular milestones related to the transition of care. Fifty-five participant units at an Association for Program Directors in Internal Medicine (APDIM) workshop prioritized the milestones, using a validated ranking process called Q-sort. We analyzed the Q-sort results, which rank the milestones in order of priority. We then applied this ranking to three innovative models of training IM residents in the transitions of care: Simulation (S), Discharge Clinic Feedback (DCF) and TRACER (T). Results. We collected 55 Q-sort rankings from particpants at the APDIM workshop. We then identified which milestones are a focus of the three innovative models of training in the transition of care: Simulation = 5 of 22 milestones, Discharge Clinic Feedback = 9 of 22 milestones, and TRACER = 7 of 22 milestones. Milestones identified in each innovation related to one of the top 8 prioritized milestones 75% of the time; thus, more frequently than the milestones with lower priority. Two milestones are shared by all three curricula: Utilize patient-centered education and Ensure succinct written communication. Two other milestones are shared by two curricula: Manage and coordinate care transitions across multiple delivery systems and Customize care in the context of the patient's preferences. If you combine the three innovations, all of the top 8 milestones are included. Discussion. The milestones give us a context to share individual innovations and to compare and contrast using a standardized frame. We demonstrate that the

  12. 48 CFR 1352.271-73 - Schedule of work.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... of work. As prescribed in 48 CFR 1371.104, insert the following clause. Schedule of Work (APR 2010... shall identify the critical path. The Work Package Network shall show the work items, milestones, key events, and activities and shall clearly identify the critical path. The Total Manpower Loading...

  13. 48 CFR 1352.271-73 - Schedule of work.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... of work. As prescribed in 48 CFR 1371.104, insert the following clause. Schedule of Work (APR 2010... shall identify the critical path. The Work Package Network shall show the work items, milestones, key events, and activities and shall clearly identify the critical path. The Total Manpower Loading...

  14. Genetic Counseling Milestones: A Framework for Student Competency Evaluation.

    PubMed

    Guy, Carrie

    2016-08-01

    Graduate medical education has recently increased focus on the development of medical specialty competency milestones to provide a targeted tool for medical resident evaluation. Milestones provide developmental assessment of the attainment of competencies over the course of an educational program. An educational framework is described to explore the development of Genetic Counseling Milestones for the evaluation of the development of genetic counseling competencies by genetic counseling students. The development of Genetic Counseling Milestones may provide a valuable tool to assess genetic counseling students across all program activities. Historical educational context, current practices, and potential benefits and challenges in the development of Genetic Counseling Milestones are discussed.

  15. Optimal stimulus scheduling for active estimation of evoked brain networks

    NASA Astrophysics Data System (ADS)

    Kafashan, MohammadMehdi; Ching, ShiNung

    2015-12-01

    Objective. We consider the problem of optimal probing to learn connections in an evoked dynamic network. Such a network, in which each edge measures an input-output relationship between sites in sensor/actuator-space, is relevant to emerging applications in neural mapping and neural connectivity estimation. Approach. We show that the problem of scheduling nodes to a probe (i.e., stimulate) amounts to a problem of optimal sensor scheduling. Main results. By formulating the evoked network in state-space, we show that the solution to the greedy probing strategy has a convenient form and, under certain conditions, is optimal over a finite horizon. We adopt an expectation maximization technique to update the state-space parameters in an online fashion and demonstrate the efficacy of the overall approach in a series of detailed numerical examples. Significance. The proposed method provides a principled means to actively probe time-varying connections in neuronal networks. The overall method can be implemented in real time and is particularly well-suited to applications in stimulation-based cortical mapping in which the underlying network dynamics are changing over time.

  16. FY11 Level-2 Milestone 3953: TLCC2 contract awarded

    SciTech Connect

    Carnes, B

    2011-09-12

    This report documents completion of FY11 L2 milestone No.3953-TLCC2 contract award. This milestone was scheduled for completion on 3/31/11 and was completed on 4/14/11. There is a separate milestone (3856), due at the end of the fiscal year, concerned with installation of the first LLNL SU and early user access. Efforts related to this tri-lab L2 milestone started early in 2010 with the development of tri-lab requirements for the second ASC capacity system procurement. The SOW was then developed along with necessary RFP paperwork and sent to HQ/DOE for their review prior to being released. There was significant delay in getting this step completed which led to this milestone being put at risk for several months. However, once the RFP was approved and released we were able to get the procurement back on track with aggressive proposal response and review timelines.

  17. Establishing Derived Textual Control in Activity Schedules with Children with Autism

    ERIC Educational Resources Information Center

    Miguel, Caio F.; Yang, Heejean G.; Finn, Heather E.; Ahearn, William H.

    2009-01-01

    Activity schedules are often used to facilitate task engagement and transition for children with autism. This study evaluated whether conditional discrimination training would serve to transfer the control from activity-schedule pictures to printed words (i.e., derived textual control). Two preschoolers with autism were taught to select pictures…

  18. Effectiveness of Instruction Performed through Computer-Assisted Activity Schedules on On-Schedule and Role-Play Skills of Children with Autism Spectrum Disorder

    ERIC Educational Resources Information Center

    Ulke-Kurkcuoglu, Burcu; Bozkurt, Funda; Cuhadar, Selmin

    2015-01-01

    This study aims to investigate the effectiveness of the instruction process provided through computer-assisted activity schedules in the instruction of on-schedule and role-play skills to children with autism spectrum disorder. Herein, a multiple probe design with probe conditions across participants among single subject designs was used. Four…

  19. Active Solution Space and Search on Job-shop Scheduling Problem

    NASA Astrophysics Data System (ADS)

    Watanabe, Masato; Ida, Kenichi; Gen, Mitsuo

    In this paper we propose a new searching method of Genetic Algorithm for Job-shop scheduling problem (JSP). The coding method that represent job number in order to decide a priority to arrange a job to Gannt Chart (called the ordinal representation with a priority) in JSP, an active schedule is created by using left shift. We define an active solution at first. It is solution which can create an active schedule without using left shift, and set of its defined an active solution space. Next, we propose an algorithm named Genetic Algorithm with active solution space search (GA-asol) which can create an active solution while solution is evaluated, in order to search the active solution space effectively. We applied it for some benchmark problems to compare with other method. The experimental results show good performance.

  20. Scheduling Software

    NASA Technical Reports Server (NTRS)

    1993-01-01

    Advanced Scheduling Environment is a software product designed and marketed by AVYX, Inc. to provide scheduling solutions for complex manufacturing environments. It can be adapted to specific scheduling and manufacturing processes and has led to substantial cost savings. The system was originally developed for NASA use in scheduling Space Shuttle flights and satellite activities. AVYX, Inc. is an offshoot of a company formed to provide computer-related services to NASA. TREES-plus, the company's initial product became the programming language for the advanced scheduling environment system.

  1. Incorporating Active Runway Crossings in Airport Departure Scheduling

    NASA Technical Reports Server (NTRS)

    Gupta, Gautam; Malik, Waqar; Jung, Yoon C.

    2010-01-01

    A mixed integer linear program is presented for deterministically scheduling departure and ar rival aircraft at airport runways. This method addresses different schemes of managing the departure queuing area by treating it as first-in-first-out queues or as a simple par king area where any available aircraft can take-off ir respective of its relative sequence with others. In addition, this method explicitly considers separation criteria between successive aircraft and also incorporates an optional prioritization scheme using time windows. Multiple objectives pertaining to throughput and system delay are used independently. Results indicate improvement over a basic first-come-first-serve rule in both system delay and throughput. Minimizing system delay results in small deviations from optimal throughput, whereas minimizing throughput results in large deviations in system delay. Enhancements for computational efficiency are also presented in the form of reformulating certain constraints and defining additional inequalities for better bounds.

  2. Scheduling: A guide for program managers

    NASA Technical Reports Server (NTRS)

    1994-01-01

    The following topics are discussed concerning scheduling: (1) milestone scheduling; (2) network scheduling; (3) program evaluation and review technique; (4) critical path method; (5) developing a network; (6) converting an ugly duckling to a swan; (7) network scheduling problem; (8) (9) network scheduling when resources are limited; (10) multi-program considerations; (11) influence on program performance; (12) line-of-balance technique; (13) time management; (14) recapitulization; and (15) analysis.

  3. Milestones in electron crystallography.

    PubMed

    Renault, Ludovic; Chou, Hui-Ting; Chiu, Po-Lin; Hill, Rena M; Zeng, Xiangyan; Gipson, Bryant; Zhang, Zi Yan; Cheng, Anchi; Unger, Vinzenz; Stahlberg, Henning

    2006-01-01

    Electron crystallography determines the structure of membrane embedded proteins in the two-dimensionally crystallized state by cryo-transmission electron microscopy imaging and computer structure reconstruction. Milestones on the path to the structure are high-level expression, purification of functional protein, reconstitution into two-dimensional lipid membrane crystals, high-resolution imaging, and structure determination by computer image processing. Here we review the current state of these methods. We also created an Internet information exchange platform for electron crystallography, where guidelines for imaging and data processing method are maintained. The server (http://2dx.org) provides the electron crystallography community with a central information exchange platform, which is structured in blog and Wiki form, allowing visitors to add comments or discussions. It currently offers a detailed step-by-step introduction to image processing with the MRC software program. The server is also a repository for the 2dx software package, a user-friendly image processing system for 2D membrane protein crystals.

  4. Increasing Completion of Classroom Routines through the Use of Picture Activity Schedules

    ERIC Educational Resources Information Center

    Watson, Kamille J.; DiCarlo, Cynthia F.

    2016-01-01

    Teachers spend the first few days of school teaching routines to children that will help transitions in the classroom between different activities. When children have difficulty, they move more slowly and/or require teacher prompting. A picture activity schedule intervention (Breitfelder in Teach Except Child Plus 4(5):2-15, 2008; Bryan and Gast…

  5. XOPPS - OEL PROJECT PLANNER/SCHEDULER TOOL

    NASA Technical Reports Server (NTRS)

    Mulnix, C. L.

    1994-01-01

    XOPPS is a window-based graphics tool for scheduling and project planning that provides easy and fast on-screen WYSIWYG editing capabilities. It has a canvas area which displays the full image of the schedule being edited. The canvas contains a header area for text and a schedule area for plotting graphic representations of milestone objects in a flexible timeline. XOPPS is object-oriented, but it is unique in its capability for creating objects that have date attributes. Each object on the screen can be treated as a unit for moving, editing, etc. There is a mouse interface for simple control of pointer location. The user can position objects to pixel resolution, but objects with an associated date are positioned automatically in their correct timeline position in the schedule area. The schedule area has horizontal lines across the page with capabilities for multiple pages and for editing the number of lines per page and the line grid. The text on a line can be edited and a line can be moved with all objects on the line moving with it. The timeline display can be edited to plot any time period in a variety of formats from Fiscal year to Calendar Year and days to years. Text objects and image objects (rasterfiles and icons) can be created for placement anywhere on the page. Milestone event objects with a single associated date (and optional text and milestone symbol) and activity objects with start and end dates (and an optional completion date) have unique editing panels for entering data. A representation for schedule slips is also provided with the capability to automatically convert a milestone event to a slip. A milestone schedule on another computer can be saved to an ASCII file to be read by XOPPS. The program can print a schedule to a PostScript file. Dependencies between objects can also be displayed on the chart through the use of precedence lines. This program is not intended to replace a commercial scheduling/project management program. Because XOPPS has

  6. Developmental Milestones of Early Literacy

    MedlinePlus

    ... developmental milestones of early literacy. Younger Than 6 Months: Never Too Young Unlike solid foods , it is ... counts, so have fun with it! 6–12 Months: Developing a Taste for Books Whatever babies are ...

  7. Milestoning without a Reaction Coordinate

    PubMed Central

    Májek, Peter; Elber, Ron

    2010-01-01

    Milestoning is a method for calculating kinetics and thermodynamics of long time processes typically not accessible for straightforward Molecular Dynamics (MD) simulation. In the Milestoning approach, the system of interest is partitioned into cells by dividing hypersurfaces (Milestones) and transitions are computed between nearby hypersurfaces. Kinetics and thermodynamics are derived from the statistics of these transitions. The original Milestoning work concentrated on systems in which a one-dimensional reaction coordinate or an order parameter could be identified. In many biomolecular processes the reaction proceeds via multiple channels or following more than a single order parameter. A description based on a one-dimensional reaction coordinate may be insufficient. In the present paper we introduce a variation that overcomes this limitation. Following the ideas of Vanden-Eijnden and Venturoli on Voronoi cells that avoid the use of an order parameter (J. Chem. Phys. 2009, 130, 194101), we describe another way to “Milestone” systems without a reaction coordinate. We examine the assumptions of the Milestoning calculations of mean first passage times (MFPT) and describe strategies to weaken these assumptions. The method described in this paper, Directional Milestoning, arranges hypersurfaces in higher dimensions that “tag” trajectories such that efficient calculations can be done and at the same time the assumptions required for exact calculations of MFPTs are satisfied approximately. In the original Milestoning papers trajectories are initiated from an equilibrium set of conformations. Here a more accurate distribution, that mimics the first hitting point distribution, is used. We demonstrate the usage of Directional Milestoning in conformational transitions of alanine dipeptide (in vacuum and in aqueous solution) and compare the correctness, efficiency, and statistical stability of the method with exact MD and with a related method. PMID:20596240

  8. Level-1 Milestone 350 Definitions v1

    SciTech Connect

    Quinn, T

    2006-11-17

    This milestone is the direct result of work that started seven years ago with the planning for a 100-teraFLOP platform and will be satisfied when 100 teraFLOPS is placed in operation and readied for Stockpile Stewardship Program simulations. The end product of this milestone will be a production-level, high-performance computing system, code named Purple, designed to be used to solve the most demanding stockpile stewardship problems, that is, the large-scale application problems at the edge of our understanding of weapon physics. This fully functional 100 teraFLOPS system must be able to serve a diverse scientific and engineering workload. It must also have a robust code development and production environment, both of which facilitate the workload requirements. This multi-year effort includes major activities in contract management, facilities, infrastructure, system software, and user environment and support. Led by LLNL, the trilabs defined the statement of work for a 100-teraFLOP system that resulted in a contract with IBM known as the Purple contract. LLNL worked with IBM throughout the contract period to resolve issues and collaborated with the Program to resolve contractual issues to ensure delivery of a platform that best serves the Program for a reasonable cost. The Purple system represents a substantial increase in the classified compute resources at LLNL for NNSA. The center computer environment must be designed to accept the Purple system and to scale with the increase of compute resources to achieve required end-to-end services. Networking, archival storage, visualization servers, global file systems, and system software will all be enhanced to support Purple's size and architecture. IBM and LLNL are sharing responsibility for Purple's system software. LLNL is responsible for the scheduler, resource manager, and some code development tools. Through the Purple contract, IBM is responsible for the remainder of the system software including the operating

  9. A Photo Album of Earth Scheduling Landsat 7 Mission Daily Activities

    NASA Technical Reports Server (NTRS)

    Potter, William; Gasch, John; Bauer, Cynthia

    1998-01-01

    Landsat7 is a member of a new generation of Earth observation satellites. Landsat7 will carry on the mission of the aging Landsat 5 spacecraft by acquiring high resolution, multi-spectral images of the Earth surface for strategic, environmental, commercial, agricultural and civil analysis and research. One of the primary mission goals of Landsat7 is to accumulate and seasonally refresh an archive of global images with full coverage of Earth's landmass, less the central portion of Antarctica. This archive will enable further research into seasonal, annual and long-range trending analysis in such diverse research areas as crop yields, deforestation, population growth, and pollution control, to name just a few. A secondary goal of Landsat7 is to fulfill imaging requests from our international partners in the mission. Landsat7 will transmit raw image data from the spacecraft to 25 ground stations in 20 subscribing countries. Whereas earlier Landsat missions were scheduled manually (as are the majority of current low-orbit satellite missions), the task of manually planning and scheduling Landsat7 mission activities would be overwhelmingly complex when considering the large volume of image requests, the limited resources available, spacecraft instrument limitations, and the limited ground image processing capacity, not to mention avoidance of foul weather systems. The Landsat7 Mission Operation Center (MOC) includes an image scheduler subsystem that is designed to automate the majority of mission planning and scheduling, including selection of the images to be acquired, managing the recording and playback of the images by the spacecraft, scheduling ground station contacts for downlink of images, and generating the spacecraft commands for controlling the imager, recorder, transmitters and antennas. The image scheduler subsystem autonomously generates 90% of the spacecraft commanding with minimal manual intervention. The image scheduler produces a conflict-free schedule

  10. Increasing Play Skills of Children with Autism Using Activity Schedules and Correspondence Training.

    ERIC Educational Resources Information Center

    Morrison, Rebecca S.; Sainato, Diane M.; BenChaaban, Delia; Endo, Sayaka

    2002-01-01

    A study investigated the effectiveness of correspondence training and photographic activity schedules on the on-task and play correspondence behavior of four preschool children with autism in an inclusive setting. Results indicate that all participants' on-task and play correspondence behavior increased, while experimenter prompts gradually…

  11. Evaluating Visual Activity Schedules as Evidence-Based Practice for Individuals with Autism Spectrum Disorders

    ERIC Educational Resources Information Center

    Knight, Victoria; Sartini, Emily; Spriggs, Amy D.

    2015-01-01

    A comprehensive review of the literature was conducted for articles published between 1993 and 2013 to evaluate the quality of the Visual Activity Schedules (VAS) literature using current evidence-based criteria developed by Horner et al. (Except Child 71:165-179, 2005). Authors sought to determine whether VAS can be considered an evidence-based…

  12. Idaho National Engineering Laboratory Environmental Restoration Program Schedule Contingency Evaluation Report

    SciTech Connect

    Not Available

    1993-09-01

    This report represents the schedule contingency evaluation done on the FY-93 Major System Acquisition (MSA) Baseline for the Idaho National Engineering Laboratory`s (INEL) Environmental Restoration Program (EPP). A Schedule Contingency Evaluation Team (SCET) was established to evaluate schedule contingency on the MSA Baseline for the INEL ERP associated with completing work within milestones established in the baseline. Baseline schedules had been established considering enforceable deadlines contained in the Federal Facilities Agreement/Consent Order (FFA/CO), the agreement signed in 1992, by the State of Idaho, Department of Health & Welfare, the U.S. Environmental Protection Agency, Region 10, and the U.S. Department of Energy, Idaho Operations Office. The evaluation was based upon the application of standard schedule risk management techniques to the specific problems of the INEL ERP. The schedule contingency evaluation was designed to provided early visibility for potential schedule delays impacting enforceable deadlines. The focus of the analysis was on the duration of time needed to accomplish all required activities to achieve completion of the milestones in the baseline corresponding to the enforceable deadlines. Additionally, the analysis was designed to identify control of high-probability, high-impact schedule risk factors.

  13. Effects of Activity Schedules on Challenging Behavior Exhibited in Children with Autism Spectrum Disorders: A Systematic Review

    ERIC Educational Resources Information Center

    Lequia, Jenna; Machalicek, Wendy; Rispoli, Mandy J.

    2012-01-01

    We reviewed studies implementing activity schedules to decrease challenging behavior of children with autism spectrum disorders (ASD). Systematic searches of electronic databases, journals, and reference lists identified 18 studies meeting the inclusion criteria. These studies were evaluated in terms of the effectiveness of activity schedules to…

  14. 15 CFR 712.1 - Round to zero rule that applies to activities involving Schedule 1 chemicals.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... activities involving Schedule 1 chemicals. 712.1 Section 712.1 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ACTIVITIES INVOLVING SCHEDULE 1 CHEMICALS § 712.1 Round to...

  15. 15 CFR 712.1 - Round to zero rule that applies to activities involving Schedule 1 chemicals.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... activities involving Schedule 1 chemicals. 712.1 Section 712.1 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ACTIVITIES INVOLVING SCHEDULE 1 CHEMICALS § 712.1 Round to...

  16. 15 CFR 712.1 - Round to zero rule that applies to activities involving Schedule 1 chemicals.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... activities involving Schedule 1 chemicals. 712.1 Section 712.1 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ACTIVITIES INVOLVING SCHEDULE 1 CHEMICALS § 712.1 Round to...

  17. 15 CFR 712.1 - Round to zero rule that applies to activities involving Schedule 1 chemicals.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... activities involving Schedule 1 chemicals. 712.1 Section 712.1 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ACTIVITIES INVOLVING SCHEDULE 1 CHEMICALS § 712.1 Round to...

  18. 15 CFR 712.1 - Round to zero rule that applies to activities involving Schedule 1 chemicals.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... activities involving Schedule 1 chemicals. 712.1 Section 712.1 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ACTIVITIES INVOLVING SCHEDULE 1 CHEMICALS § 712.1 Round to...

  19. Scheduling game

    SciTech Connect

    Kleck, W

    1982-04-01

    Structuring a schedule - whether by Critical Path Method (CPM) or Precedence Charting System (PCS) - involves estimating the duration of one or more activities and arranging them in the most logical sequence. Given the start date, the completion date is relatively simple to determine. What is then so complicated about the process. It is complicated by the people involved - the people who make the schedules and the people who attempt to follow them. Schedules are an essential part of project management and construction contract administration. Much of the material available pertains to the mechanics of schedules, the types of logic networks, the ways that data can be generated and presented. This paper sheds light on other facets of the subject - the statistical and philosophical fundamentals involved in scheduling.

  20. HURON (HUman and Robotic Optimization Network) Multi-Agent Temporal Activity Planner/Scheduler

    NASA Technical Reports Server (NTRS)

    Hua, Hook; Mrozinski, Joseph J.; Elfes, Alberto; Adumitroaie, Virgil; Shelton, Kacie E.; Smith, Jeffrey H.; Lincoln, William P.; Weisbin, Charles R.

    2012-01-01

    HURON solves the problem of how to optimize a plan and schedule for assigning multiple agents to a temporal sequence of actions (e.g., science tasks). Developed as a generic planning and scheduling tool, HURON has been used to optimize space mission surface operations. The tool has also been used to analyze lunar architectures for a variety of surface operational scenarios in order to maximize return on investment and productivity. These scenarios include numerous science activities performed by a diverse set of agents: humans, teleoperated rovers, and autonomous rovers. Once given a set of agents, activities, resources, resource constraints, temporal constraints, and de pendencies, HURON computes an optimal schedule that meets a specified goal (e.g., maximum productivity or minimum time), subject to the constraints. HURON performs planning and scheduling optimization as a graph search in state-space with forward progression. Each node in the graph contains a state instance. Starting with the initial node, a graph is automatically constructed with new successive nodes of each new state to explore. The optimization uses a set of pre-conditions and post-conditions to create the children states. The Python language was adopted to not only enable more agile development, but to also allow the domain experts to easily define their optimization models. A graphical user interface was also developed to facilitate real-time search information feedback and interaction by the operator in the search optimization process. The HURON package has many potential uses in the fields of Operations Research and Management Science where this technology applies to many commercial domains requiring optimization to reduce costs. For example, optimizing a fleet of transportation truck routes, aircraft flight scheduling, and other route-planning scenarios involving multiple agent task optimization would all benefit by using HURON.

  1. OPPS - OEL PROJECT PLANNER/SCHEDULER

    NASA Technical Reports Server (NTRS)

    Murphy, S. C.

    1994-01-01

    OPPS is a window-based graphics tool that provides easy and fast on-screen WYSIWYG editing capabilities. It has a canvas area which displays a full image of the schedule being edited. The canvas contains a header area (for text) and a schedule area (for plotting graphic representations of milestone objects in a flexible timeline). The OPPS tool is object-oriented, but it is unique in its capability for creating objects that have date attributes. Each object on the screen can be treated as a unit for moving, editing, etc. There is a mouse interface for simple control of pointer location. The user can position objects to pixel resolution, but objects with an associated date are positioned automatically in their correct timeline position in the schedule area. The schedule area has horizontal lines across the page with capabilities for multiple pages and for editing the number of lines per page and the line grid. The text on a line can be edited and a line can be moved with all objects on the line moving with it. The timeline display can be edited to plot any time period in a variety of formats from Fiscal Year to Calendar Year and days to years. Text objects and image objects (rasterfiles and icons) can be created for placement anywhere on the page. Milestone event objects with a single associated date (and optional text and milestone symbol) and activity objects with start and end dates (and an optional completion date) have unique editing panels for entering data. A representation for schedule slips is also provided. A milestone schedule can be saved to an ASCII file on another computer to be read by OPPS. The program can also print a schedule to a PostScript file. This program is not intended to replace a commercial scheduling/project management program. It does not provide the capability for defining dependencies between activities; dates must be provided manually. However, because OPPS has an ASCII file interface it can be used in conjunction with a project

  2. Speech and Language Developmental Milestones

    MedlinePlus

    ... What are the milestones for speech and language development? The first signs of communication occur when an infant learns that a cry will bring food, comfort, and companionship. Newborns also begin to recognize important sounds in their environment, such as the voice of their mother or ...

  3. An application of the active time model to multiple concurrent variable-interval schedules.

    PubMed

    Brown, Emily Kathryn; Cleaveland, J Mark

    2009-06-01

    The current experiment investigates whether an active time model can account for anomalous results that have emerged from multiple schedule, concurrent variable-interval (VI) VI experiments. The model assumes that (1) during concurrent VI VI training pigeons learn a function that relates time since the most immediate response, i.e., active time, to changeover probabilities and (2) that molar preference is the result of an interaction between inter-response time frequencies and the learned active time changeover functions. Pigeons were trained under a concurrent VI 30-s VI 30-s schedule and a concurrent VI 60-s VI 60-s schedule. Probes were conducted in which VI 30-s and VI 60-s stimuli were paired. During these probes, birds allocated choices equally to the stimuli. The active time model accurately fit individual subject data. In contrast data were not fit by a variant of scalar expectancy theory proposed by Gibbon [Gibbon, J., 1995. Dynamics of time matching: arousal makes better seem worse. Psychon. Bull. Rev. 2, 208-215].

  4. An Optimal CDS Construction Algorithm with Activity Scheduling in Ad Hoc Networks.

    PubMed

    Penumalli, Chakradhar; Palanichamy, Yogesh

    2015-01-01

    A new energy efficient optimal Connected Dominating Set (CDS) algorithm with activity scheduling for mobile ad hoc networks (MANETs) is proposed. This algorithm achieves energy efficiency by minimizing the Broadcast Storm Problem [BSP] and at the same time considering the node's remaining energy. The Connected Dominating Set is widely used as a virtual backbone or spine in mobile ad hoc networks [MANETs] or Wireless Sensor Networks [WSN]. The CDS of a graph representing a network has a significant impact on an efficient design of routing protocol in wireless networks. Here the CDS is a distributed algorithm with activity scheduling based on unit disk graph [UDG]. The node's mobility and residual energy (RE) are considered as parameters in the construction of stable optimal energy efficient CDS. The performance is evaluated at various node densities, various transmission ranges, and mobility rates. The theoretical analysis and simulation results of this algorithm are also presented which yield better results.

  5. Using Activity Schedules to Increase On-Task Behavior in Children at Risk for Attention-Deficit/Hyperactivity Disorder

    ERIC Educational Resources Information Center

    Cirelli, Christe A.; Sidener, Tina M.; Reeve, Kenneth F.; Reeve, Sharon A.

    2016-01-01

    The effects of activity schedules on on-task and on-schedule behavior were assessed with two boys at risk for attention-deficit/hyperactivity disorder (ADHD) and referred by their public school teachers as having difficulty during independent work time. On-task behavior increased for both participants after two training sessions. Teachers, peers,…

  6. Detailed leak detection test plan and schedule for the Oak Ridge National Laboratory LLLW active tanks

    SciTech Connect

    Douglas, D.G.; Maresca, J.W. Jr. )

    1993-03-01

    This document provides a detailed leak detection test plan and schedule for leak testing many of the tanks that comprise the active portion of the liquid low-level waste (LLLW) system at the Oak Ridge National Laboratory (ORNL). This plan was prepared in response to the requirements of the Federal Facility Agreement (FFA) between the US Department of Energy (DOE) and two other agencies, the US Environmental Protection Agency (EPA) and the Tennessee Department of Environment and Conservation (TDEC).

  7. 14 CFR 1274.908 - Milestone payments.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Milestone payments. 1274.908 Section 1274.908 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION COOPERATIVE AGREEMENTS WITH COMMERCIAL FIRMS Other Provisions and Special Conditions § 1274.908 Milestone payments. Milestone Payments July 2002 (a) By submission of the...

  8. Early Language Milestones and Specific Language Impairment

    ERIC Educational Resources Information Center

    Rudolph, Johanna M.; Leonard, Laurence B.

    2016-01-01

    Delayed appearance of early language milestones can be one of the first signs of a developmental disorder. In this study, we investigated how well late acquisition of language milestones predicted an outcome of specific language impairment (SLI). The sample included 150 children (76 SLI), aged 4 to 7 years old. Milestone information was collected…

  9. September 2014 Milestone Report

    SciTech Connect

    Britton, Jr, Charles L.; Shelton, Jacob H.; Ericson, Milton Nance; Bobrek, Miljko; Blalock, Benjamin

    2014-10-01

    This is a report of the activities involving Task 2 of the NEET 2 project Radiation Hardened Circuitry Using Mask-Programmable Analog Arrays [1]. Using the analog blocks available in our currently pre-configured Via-Configured Array (VCA), we will perform a detailed schematic design of our system to include the signal-processing blocks for temperature, radiation and pressure. Control and data acquisition will be implemented with the Spartan-6 Field-Programmable Gate Array (FPGA) as well as wired serial communications with a remote computer to be used with this project. In addition, batteries and associated voltage regulators will be selected for powering the system. Fabrication may include a polyimide, printed circuit board (PCB) for improved radiation and temperature tolerance. The PCB will go through a layout process by one of the organizations we utilize for this function and be fabricated by another external vendor. Population of the system board will be performed using one of our in-house technicians or an outside vendor we commonly use. Five prototype systems (sensors, electronics board, battery power supply, and personal computer (PC) serial communications port) will be constructed to support the testing objectives of this work. Quality assurance will be performed at each step by both the submitters and the vendors.

  10. A further application of the active time model to multiple concurrent variable-interval schedules.

    PubMed

    McKenzie, Andrew T; Cleaveland, J Mark

    2010-05-01

    In this experiment we show that the active time model (ATM) accurately predicts probe data from multiple concurrent VI VI schedules. Subjects were trained under a concurrent VI 30-s VI 60-s and a concurrent VI 60-s VI 120-s schedule. Two types of unreinforced probes were then conducted. The first paired the two VI 60-s stimuli. These stimuli, while equivalent in their associated absolute rates of reinforcement, differed in their relative rates of reinforcement. The second probe paired the VI 30-s stimulus with the relatively rich VI 60-s stimulus. In contrast with the first probe, these stimuli differed in their absolute rates of reinforcement, while being similar in their relative rates. During the first set of probes, birds preferred the VI 60-s stimulus trained with the VI 120-s schedule. During the second set of probes, birds were indifferent to the two stimuli. These results are less extreme than others reported in the literature. Nonetheless, we found that ATM accurately fit individual subject data in both sets of probes. In contrast a variant of scalar expectancy theory did not fit the data at either the individual or group level.

  11. Milestones

    NASA Astrophysics Data System (ADS)

    2014-09-01

    Tami Bond, environmental engineer and professor in the Department of Civil and Environmental Engineering at the University of Illinois at Urbana-Champaign, has been selected as a 2014 MacArthur Fellow.

  12. Flexible Scheduling.

    ERIC Educational Resources Information Center

    Davis, Harold S.; Bechard, Joseph E.

    A flexible schedule allows teachers to change group size, group composition, and class length according to the purpose of the lesson. This pamphlet presents various "master" schedules for flexible scheduling: (1) Simple block schedules, (2) back-to-back schedules, (3) interdisciplinary schedules, (4) school-wide block schedules, (5) open-lab…

  13. Protocols for distributive scheduling

    NASA Technical Reports Server (NTRS)

    Richards, Stephen F.; Fox, Barry

    1993-01-01

    The increasing complexity of space operations and the inclusion of interorganizational and international groups in the planning and control of space missions lead to requirements for greater communication, coordination, and cooperation among mission schedulers. These schedulers must jointly allocate scarce shared resources among the various operational and mission oriented activities while adhering to all constraints. This scheduling environment is complicated by such factors as the presence of varying perspectives and conflicting objectives among the schedulers, the need for different schedulers to work in parallel, and limited communication among schedulers. Smooth interaction among schedulers requires the use of protocols that govern such issues as resource sharing, authority to update the schedule, and communication of updates. This paper addresses the development and characteristics of such protocols and their use in a distributed scheduling environment that incorporates computer-aided scheduling tools. An example problem is drawn from the domain of space shuttle mission planning.

  14. Using Video-Enhanced Activity Schedules and Matrix Training to Teach Sociodramatic Play to a Child with Autism

    ERIC Educational Resources Information Center

    Dauphin, Melissa; Kinney, Elisabeth M.; Stromer, Robert; Koegel, R. L.

    2004-01-01

    We evaluated an intervention package for teaching generative sociodramatic play activities to a young boy with an autism spectrum disorder. In Phase 1, the boy learned computer activity schedules that featured embedded video models of what to say and do. A 3 x 3 instructional matrix defined 9 activities to be performed involving combinations of 3…

  15. The MILE Guide: Milestones for Improving Learning & Education

    ERIC Educational Resources Information Center

    Partnership for 21st Century Skills, 2009

    2009-01-01

    Every district will benefit from understanding where it sits on the continuum of 21st century skills integration. The Milestones for Improving Learning & Education (MILE) Guide Self-Assessment tool helps districts accomplish this essential first step, covering the primary responsibilities and activities within a district. Subjects covered include:…

  16. Wave scheduling - Decentralized scheduling of task forces in multicomputers

    NASA Technical Reports Server (NTRS)

    Van Tilborg, A. M.; Wittie, L. D.

    1984-01-01

    Decentralized operating systems that control large multicomputers need techniques to schedule competing parallel programs called task forces. Wave scheduling is a probabilistic technique that uses a hierarchical distributed virtual machine to schedule task forces by recursively subdividing and issuing wavefront-like commands to processing elements capable of executing individual tasks. Wave scheduling is highly resistant to processing element failures because it uses many distributed schedulers that dynamically assign scheduling responsibilities among themselves. The scheduling technique is trivially extensible as more processing elements join the host multicomputer. A simple model of scheduling cost is used by every scheduler node to distribute scheduling activity and minimize wasted processing capacity by using perceived workload to vary decentralized scheduling rules. At low to moderate levels of network activity, wave scheduling is only slightly less efficient than a central scheduler in its ability to direct processing elements to accomplish useful work.

  17. Pu-238 fuel form activities, January 1-31, 1982

    SciTech Connect

    Not Available

    1982-03-01

    This monthly report for /sup 238/Pu fuel form activities has two main sections: SRP-PuFF facility and SRL fuel form activities. The program status, budget information, and milestone schedules are discussed in each main section. The Work Breakdown Structure (WBS) for this program is shown. Only one monthly report per year is processed for EDB.

  18. Pu-238 fuel form activities, January 1-31, 1981

    SciTech Connect

    Not Available

    1981-02-01

    This monthly report for /sup 238/Pu Fuel Form Activities has two main sections: SRP-PuFF facility and SRL Fuel Form Activities. The program status, budget information, and milestone schedules are discussed in each main section. The Work Breakdown Structure (WBS) for this program is shown. Only one monthly report per year is processed for EDB.

  19. Pu-238 fuel form activities, January 1-31, 1983

    SciTech Connect

    Not Available

    1983-03-01

    This monthly report for /sup 238/Pu Fuel Form Activities has two main sections: SRP-PuFF facility and SRL Fuel Form Activities. The program status, budget information, and milestone schedules are discussed in each main section. The Work Breakdown Structure (WBS) for this program is shown. Only one monthly report per year is processed for EDB.

  20. [Microbial activity and functional diversity in rhizosphere of cucumber under different subsurface drip irrigation scheduling].

    PubMed

    Li, Hua; He, Hong-Jun; Li, Teng-Fei; Zhang, Zi-Kun

    2014-08-01

    The effects of subsurface drip irrigation scheduling on microbial activity and functional diversity in rhizosphere of cucumber in solar greenhouse were studied in this paper. The results showed that the soil microbial biomass C and N, basal respiration, metabolic quotient and values of AWCD, Shannon and McIntosh indexes were increased at first and then decreased with the increase of irrigation water amount. The values of microbial C and N, basal respiration and metabolic quotient in I2 treatments were significantly higher than those in I1 treatments at the 0.8E(p) irrigation level. The numbers of bacteria, actinomyces and nitrogen-fixing bacteria, and the activities of urease, phosphatase, sucrase, catalase and polyhenoloxidase were significantly higher in the 0.8E(p) treatment than in the other treatments. The numbers of bacteria and nitrogen-fixing bacteria, the activities of urease, phosphatase and sucrase in I2 treatments were significantly higher than in I1 treatment, the actinomyces number and activities of catalase and polyhenoloxidase had no significant difference between I1 and I2 treatments, however, the fungi number in I2 treatments were significantly lower than in I2 treaments at the 0.8E(p) irrigation level. The microbial activity and functional diversity in rhizosphere of cucumber were strengthened in the I20.8E(p) treatment, meanwhile, the soil microflora was improved and the soil enzymes activities were enhanced, therefore, the cucumber growth was promoted as well.

  1. Megagauss X: a conference milestone /

    SciTech Connect

    Fowler, C. M.

    2004-01-01

    The first Megagauss Conference now known as MG I, was held in 1965. Thirty-nine years later, we are now attending MG X. As topical conferences go, this is a fairly long time. For comparison, the first IEEE International Pulsed Power Conference was held in 1976. It seems appropriate in the opening address of this 'Milestone' conference to note some highlights of the earlier MG conferences. Some relatively new research lines in progress will also be noted, as well as the speaker's 'wish list' of projects he would like to see pursued. Mention will be made of the growing number of explosive flux compression facilities around the world, as well as some facilities that no longer exist, but that made significant contributions in their time.

  2. 14 CFR 1274.908 - Milestone payments.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... July 2002 (a) By submission of the first invoice, the Recipient is certifying that it has an... following milestones: Date PaymentMilestone Amount (c) Upon submission by the recipient of invoices in... after receipt of proper invoice. Payment shall be considered as being made on the date of...

  3. Hybrid Particle Swarm Optimization for Hybrid Flowshop Scheduling Problem with Maintenance Activities

    PubMed Central

    Li, Jun-qing; Pan, Quan-ke; Mao, Kun

    2014-01-01

    A hybrid algorithm which combines particle swarm optimization (PSO) and iterated local search (ILS) is proposed for solving the hybrid flowshop scheduling (HFS) problem with preventive maintenance (PM) activities. In the proposed algorithm, different crossover operators and mutation operators are investigated. In addition, an efficient multiple insert mutation operator is developed for enhancing the searching ability of the algorithm. Furthermore, an ILS-based local search procedure is embedded in the algorithm to improve the exploitation ability of the proposed algorithm. The detailed experimental parameter for the canonical PSO is tuning. The proposed algorithm is tested on the variation of 77 Carlier and Néron's benchmark problems. Detailed comparisons with the present efficient algorithms, including hGA, ILS, PSO, and IG, verify the efficiency and effectiveness of the proposed algorithm. PMID:24883414

  4. Scheduled daily mating induces circadian anticipatory activity rhythms in the male rat.

    PubMed

    Landry, Glenn J; Opiol, Hanna; Marchant, Elliott G; Pavlovski, Ilya; Mear, Rhiannon J; Hamson, Dwayne K; Mistlberger, Ralph E

    2012-01-01

    Daily schedules of limited access to food, palatable high calorie snacks, water and salt can induce circadian rhythms of anticipatory locomotor activity in rats and mice. All of these stimuli are rewarding, but whether anticipation can be induced by neural correlates of reward independent of metabolic perturbations associated with manipulations of food and hydration is unclear. Three experiments were conducted to determine whether mating, a non-ingestive behavior that is potently rewarding, can induce circadian anticipatory activity rhythms in male rats provided scheduled daily access to steroid-primed estrous female rats. In Experiment 1, rats anticipated access to estrous females in the mid-light period, but also exhibited post-coital eating and running. In Experiment 2, post-coital eating and running were prevented and only a minority of rats exhibited anticipation. Rats allowed to see and smell estrous females showed no anticipation. In both experiments, all rats exhibited sustained behavioral arousal and multiple mounts and intromissions during every session, but ejaculated only every 2-3 days. In Experiment 3, the rats were given more time with individual females, late at night for 28 days, and then in the midday for 28 days. Ejaculation rates increased and anticipation was robust to night sessions and significant although weaker to day sessions. The anticipation rhythm persisted during 3 days of constant dark without mating. During anticipation of nocturnal mating, the rats exhibited a significant preference for a tube to the mating cage over a tube to a locked cage with mating cage litter. This apparent place preference was absent during anticipation of midday mating, which may reflect a daily rhythm of sexual reward. The results establish mating as a reward stimulus capable of inducing circadian rhythms of anticipatory behavior in the male rat, and reveal a critical role for ejaculation, a modulatory role for time of day, and a potential confound role for

  5. Scheduled daily mating induces circadian anticipatory activity rhythms in the male rat.

    PubMed

    Landry, Glenn J; Opiol, Hanna; Marchant, Elliott G; Pavlovski, Ilya; Mear, Rhiannon J; Hamson, Dwayne K; Mistlberger, Ralph E

    2012-01-01

    Daily schedules of limited access to food, palatable high calorie snacks, water and salt can induce circadian rhythms of anticipatory locomotor activity in rats and mice. All of these stimuli are rewarding, but whether anticipation can be induced by neural correlates of reward independent of metabolic perturbations associated with manipulations of food and hydration is unclear. Three experiments were conducted to determine whether mating, a non-ingestive behavior that is potently rewarding, can induce circadian anticipatory activity rhythms in male rats provided scheduled daily access to steroid-primed estrous female rats. In Experiment 1, rats anticipated access to estrous females in the mid-light period, but also exhibited post-coital eating and running. In Experiment 2, post-coital eating and running were prevented and only a minority of rats exhibited anticipation. Rats allowed to see and smell estrous females showed no anticipation. In both experiments, all rats exhibited sustained behavioral arousal and multiple mounts and intromissions during every session, but ejaculated only every 2-3 days. In Experiment 3, the rats were given more time with individual females, late at night for 28 days, and then in the midday for 28 days. Ejaculation rates increased and anticipation was robust to night sessions and significant although weaker to day sessions. The anticipation rhythm persisted during 3 days of constant dark without mating. During anticipation of nocturnal mating, the rats exhibited a significant preference for a tube to the mating cage over a tube to a locked cage with mating cage litter. This apparent place preference was absent during anticipation of midday mating, which may reflect a daily rhythm of sexual reward. The results establish mating as a reward stimulus capable of inducing circadian rhythms of anticipatory behavior in the male rat, and reveal a critical role for ejaculation, a modulatory role for time of day, and a potential confound role for

  6. Completion of Level 4 Milestone M4AT-15OR2301039 for the Johnson Noise Thermometry for Drift-free Temperature Measurements Work Package AT-15OR230103

    SciTech Connect

    Britton Jr, Charles L.

    2015-09-14

    This memorandum constitutes our September 2015 level 4 milestone for the project entitled “Johnson Noise Thermometry for Drift-free Temperature Measurements” and satisfies the Milestone/Activity (Conclude HFIR field demonstration of JNT prototype). The progress summary describes the work performed to complete the subject milestone.

  7. Constraint based scheduling for the Goddard Space Flight Center distributed Active Archive Center's data archive and distribution system

    NASA Technical Reports Server (NTRS)

    Short, Nick, Jr.; Bedet, Jean-Jacques; Bodden, Lee; Boddy, Mark; White, Jim; Beane, John

    1994-01-01

    The Goddard Space Flight Center (GSFC) Distributed Active Archive Center (DAAC) has been operational since October 1, 1993. Its mission is to support the Earth Observing System (EOS) by providing rapid access to EOS data and analysis products, and to test Earth Observing System Data and Information System (EOSDIS) design concepts. One of the challenges is to ensure quick and easy retrieval of any data archived within the DAAC's Data Archive and Distributed System (DADS). Over the 15-year life of EOS project, an estimated several Petabytes (10(exp 15)) of data will be permanently stored. Accessing that amount of information is a formidable task that will require innovative approaches. As a precursor of the full EOS system, the GSFC DAAC with a few Terabits of storage, has implemented a prototype of a constraint-based task and resource scheduler to improve the performance of the DADS. This Honeywell Task and Resource Scheduler (HTRS), developed by Honeywell Technology Center in cooperation the Information Science and Technology Branch/935, the Code X Operations Technology Program, and the GSFC DAAC, makes better use of limited resources, prevents backlog of data, provides information about resources bottlenecks and performance characteristics. The prototype which is developed concurrently with the GSFC Version 0 (V0) DADS, models DADS activities such as ingestion and distribution with priority, precedence, resource requirements (disk and network bandwidth) and temporal constraints. HTRS supports schedule updates, insertions, and retrieval of task information via an Application Program Interface (API). The prototype has demonstrated with a few examples, the substantial advantages of using HTRS over scheduling algorithms such as a First In First Out (FIFO) queue. The kernel scheduling engine for HTRS, called Kronos, has been successfully applied to several other domains such as space shuttle mission scheduling, demand flow manufacturing, and avionics communications

  8. Campaign 2 Level 2 Milestone Review 2009: Milestone # 3132 Determine Sustainable TATB Source and Processing Options, and Potential Binder Options

    SciTech Connect

    Schwartz, A J

    2009-09-28

    A presentation was made to the Milestone review committee on September 18, 2009 that outlined the efforts making up the achievement of the Campaign 2, Level 2 Milestone No.3132. After the presentation and review of the collective work, the committee determined that the milestone was successfully completed. Highlights from this review are discussed here. A brief summary of the discussion points includes: (1) It was clear that this work represents a comprehensive collection of experimental, modeling, literature review, and analysis activities with a thorough attention to the details. The deliverables include 2 technical presentations and 5 written reports describing this work. (2) This is a joint LLNL/LANL milestone led by Campaign 2 with leveraging effort from other campaigns and activities at LLNL: (a) The contributing programs included Enhanced Surveillance Campaign (ESC) and Readiness Campaign. Key technical elements of this work were built on scientific advances from the Laboratory Directed Research and Development (LDRD) program. (b) Part of this work covers activities associated with the Enhanced Collaboration (EC) with the Atomic Weapons Establishment (AWE). (3) This Milestone work has supported a high-level Directed Stockpile Work (DSW) Joint DoD/DOE TATB Production Initiative. This is an example of the strong relevance of this Milestone research to current stockpile issues. A summary of the future direction in this research area includes: (1) The Ionic Liquid (IL) re-crystallization process has been demonstrated to improve the performance of recrystallized TATB molecule. However, lower thermal stability of the IL crystallized material (compared to conventional TATB) warrants further study to understand the source of this effect. (2) The compatibility issue needs to be addressed in upcoming work. One concern is how the new solvent and ionic liquid used in the formulation process might behave in the nuclear explosive assembly. Similarly, compatibility studies

  9. 15 CFR 712.2 - Restrictions on activities involving Schedule 1 chemicals.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Schedule 1 chemicals. 712.2 Section 712.2 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS... International Traffic in Arms Regulations (22 CFR parts 120 through 130) for Schedule 1 chemicals subject to...

  10. 15 CFR 712.2 - Restrictions on activities involving Schedule 1 chemicals.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Schedule 1 chemicals. 712.2 Section 712.2 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS... International Traffic in Arms Regulations (22 CFR parts 120 through 130) for Schedule 1 chemicals subject to...

  11. 15 CFR 712.2 - Restrictions on activities involving Schedule 1 chemicals.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Schedule 1 chemicals. 712.2 Section 712.2 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS... International Traffic in Arms Regulations (22 CFR parts 120 through 130) for Schedule 1 chemicals subject to...

  12. Different effects of temperature on foraging activity schedules in sympatric Myrmecia ants.

    PubMed

    Jayatilaka, Piyankarie; Narendra, Ajay; Reid, Samuel F; Cooper, Paul; Zeil, Jochen

    2011-08-15

    Animals avoid temperatures that constrain foraging by restricting activity to specific times of the day or year. However, because temperature alters the availability of food resources, it is difficult to separate temperature-dependent effects on foraging and the occupation of temporal niches. By studying two congeneric, sympatric Myrmecia ants we isolated the effect of temperature and investigated whether temperature affects foraging schedules and causes the two ants to be active at distinct times of the day or year. We monitored foraging activity and identified the ants' temperature tolerance in the laboratory by determining (1) critical thermal minima and maxima (CT(min) and CT(max)) and (2) the relationship between walking speed and temperature. Ants of Myrmecia croslandi were diurnal throughout the year, but ceased above-ground activity during winter. Surface temperature at the onset of foraging was 9.8-30.1°C, while their laboratory CT(min) and CT(max) were 10.4 and 48.5°C, respectively. Time of foraging onset was significantly influenced by surface temperature at time of sunrise and of onset. Ants of Myrmecia pyriformis were nocturnal throughout the year. Surface temperature at the onset of foraging was 5.4-26.2°C, while their laboratory CT(min) and CT(max) were 8.2 and 41.6°C, respectively. Time of foraging onset was not influenced by surface temperature, but solely by sunset time. We conclude that temperature determines the timing of foraging as well as the daily and seasonal foraging activity in M. croslandi, but has less obvious effects on M. pyriformis. In both species, CT(max) was greater than temperatures at the natural foraging times. PMID:21795570

  13. The Over-Scheduling Hypothesis Revisited: Intensity of Organized Activity Participation during Adolescence and Young Adult Outcomes

    ERIC Educational Resources Information Center

    Mahoney, Joseph L.; Vest, Andrea E.

    2012-01-01

    Concern exists that youth who spend a lot of time participating in organized out-of-school activities (e.g., sports) are at-risk for poor developmental outcomes. This concern--called the over-scheduling hypothesis--has primarily been assessed in terms of adolescent adjustment. This longitudinal study of a nationally representative sample of 1,115…

  14. Maintaining high activity levels in sedentary adults with a reinforcement-thinning schedule.

    PubMed

    Andrade, Leonardo F; Barry, Danielle; Litt, Mark D; Petry, Nancy M

    2014-01-01

    Physical inactivity is a leading cause of mortality. Reinforcement interventions appear to be useful for increasing activity and preventing adverse consequences of sedentary lifestyles. This study evaluated a reinforcement-thinning schedule for maintaining high activity levels. Sedentary adults (N = 77) were given pedometers and encouraged to walk ≥10,000 steps per day. Initially, all participants earned rewards for each day they walked ≥10,000 steps. Subsequently, 61 participants were randomized to a monitoring-only condition or a monitoring-plus-reinforcement-thinning condition, in which frequencies of monitoring and reinforcing walking decreased over 12 weeks. The mean (± SD) percentage of participants in the monitoring-plus-reinforcement-thinning condition who met walking goals was 83% ± 24% and was 55% ± 31% for participants in the monitoring-only condition, p < .001. Thus, monitoring plus reinforcement thinning maintained high rates of walking when it was in effect; however, groups did not differ at a 24-week follow-up. Monitoring plus reinforcement thinning, nevertheless, hold potential to extend benefits of reinforcement interventions at low costs.

  15. Soil microflora and enzyme activities in rhizosphere of Transgenic Bt cotton hybrid under different intercropping systems and plant protection schedules

    NASA Astrophysics Data System (ADS)

    Biradar, D. P.; Alagawadi, A. R.; Basavanneppa, M. A.; Udikeri, S. S.

    2012-04-01

    Field experiments were conducted over three rainy seasons of 2005-06 to 2007-08 on a Vertisol at Dharwad, Karnataka, India to study the effect of intercropping and plant protection schedules on productivity, soil microflora and enzyme activities in the rhizosphere of transgenic Bt cotton hybrid. The experiment consisted of four intercropping systems namely, Bt cotton + okra, Bt cotton + chilli, Bt cotton + onion + chilli and Bt cotton + redgram with four plant protection schedules (zero protection, protection for Bt cotton, protection for intercrop and protection for both crops). Observations on microbial populations and enzyme activities were recorded at 45, 90, 135 and 185 (at harvest) days after sowing (DAS). Averaged over years, Bt cotton + okra intercropping had significantly higher total productivity than Bt cotton + chilli and Bt cotton + redgram intercropping system and was similar to Bt cotton + chilli + onion intercropping system. With respect to plant protection schedules for bollworms, protection for both cotton and intercrops recorded significantly higher yield than the rest of the treatments. Population of total bacteria, fungi, actinomycetes, P-solubilizers, free-living N2 fixers as well as urease, phosphatase and dehydrogenase enzyme activities increased up to 135 days of crop growth followed by a decline. Among the intercropping systems, Bt cotton + chilli recorded significantly higher population of microorganisms and enzyme activities than other cropping systems. While Bt cotton with okra as intercrop recorded the least population of total bacteria and free-living N2 fixers as well as urease activity. Intercropping with redgram resulted in the least population of actinomycetes, fungi and P-solubilizers, whereas Bt cotton with chilli and onion recorded least activities of dehydrogenase and phosphatase. Among the plant protection schedules, zero protection recorded maximum population of microorganisms and enzyme activities. This was followed by the

  16. Development of a radiopharmaceutical activity schedule for technetium-99m dimercaptosuccinic acid in children based on image quality criteria.

    PubMed

    Smith, T; Gordon, I; Evans, K; Anderson, P J; Lythgoe, M F

    1997-11-01

    The aim of this study was to determine an activity schedule (amount of administered activity in relation to body weight) for technetium-99m dimercaptosuccinic acid examinations in children, from information present in renal scintigraphic images. Scans from 48 children (5 weeks to 14.8 years old) were graded for image quality according to the clarity of both kidney outline and internal structure. Numerical image data (kidney and background counts, signal-to-noise ratio) were associated with these subjective gradings to formulate three criteria, specifying the required values of the above-measured parameters to yield optimum grades of image quality. When applied to derived functions, a kidney uptake of 20% was required to satisfy the criterion based on the signal-to-noise ratio. Using this value with the other two criteria predicts the form of the weight-dependent activity schedule as a function of imaging time. Examples of schedules for imaging times of 300 and 600 s are compared with a schedule based on surface area.

  17. Sulforaphane Bioavailability and Chemopreventive Activity in Women Scheduled for Breast Biopsy.

    PubMed

    Atwell, Lauren L; Zhang, Zhenzhen; Mori, Motomi; Farris, Paige E; Vetto, John T; Naik, Arpana M; Oh, Karen Y; Thuillier, Philippe; Ho, Emily; Shannon, Jackilen

    2015-12-01

    Epidemiologic studies suggest a protective effect of cruciferous vegetables on breast cancer. Sulforaphane (SFN), an active food component derived from crucifers, has been shown to be effective in breast cancer chemoprevention. This study evaluated the chemopreventive effect of SFN on selective biomarkers from blood and breast tissues. In a 2- to 8-week double-blinded, randomized controlled trial, 54 women with abnormal mammograms and scheduled for breast biopsy were randomized to consume a placebo or a glucoraphanin (GFN) supplement providing SFN (n = 27). Plasma and urinary SFN metabolites, peripheral blood mononuclear cell (PBMC) histone deacetylase (HDAC) activity, and tissue biomarkers (H3K18ac, H3K9ac, HDAC3, HDAC6, Ki-67, p21) were measured before and after the intervention in benign, ductal carcinoma in situ, or invasive ductal carcinoma breast tissues. Within the supplement group, Ki-67 (P = 0.003) and HDAC3 (P = 0.044) levels significantly decreased in benign tissue. Pre-to-postintervention changes in these biomarkers were not significantly different between treatment groups after multiple comparison adjustment. GFN supplementation was associated with a significant decrease in PBMC HDAC activity (P = 0.04). No significant associations were observed between SFN and examined tissue biomarkers when comparing treatment groups. This study provides evidence that GFN supplementation for a few weeks is safe but may not be sufficient for producing changes in breast tissue tumor biomarkers. Future studies employing larger sample sizes should evaluate alternative dosing and duration regimens to inform dietary SFN strategies in breast cancer chemoprevention. PMID:26511489

  18. Specific activity of tissue culture antirabic vaccine Rabivak-Vnukovo-32 with short intramuscular vaccination schedule.

    PubMed

    Selimov, M A; Toigombaeva, V S; Zgurskaya, G N; Kulikova, L G; Kodkind, G Kh

    1988-05-01

    Tissue culture rabies vaccine has been used for subcutaneous immunization of 158 subjects according to official instructions and also for intramuscular immunization of 128 subjects according to a short schedule with booster inoculations. All 286 subjects were either bitten or contaminated with saliva of rabid animals or animals suspected of having rabies. The 1168 serum samples were tested by neutralization test (NT) in mice, by radial haemolysis (RH) and by indirect haemagglutination (IHA). The highest, earliest and longest active post-vaccination immunity was registered after the most intensive subcutaneous vaccination course at a dose of 5 ml for 25 days with 3 booster inoculations. Subcutaneous inoculation of 3 ml vaccine for 12 days (36 ml) failed to produce a satisfactory elevation of antibody titre. After 2 to 4 booster inoculations, however, a satisfactory level of antibody was observed. The tissue culture vaccine was shown to have good prospects for clinical vaccination by intramuscular route. On intramuscular vaccination at 1.5 ml for 9 days with 6 booster inoculations on days 16, 23, 30, 37, 67 and 97 (initial vaccine volume 45 ml) the mean geometric antibody titres (MGT) reached 93, 160, 322 and 165 on days 30, 60, 90 and 112, respectively. The economically efficient and rapid IHA and RH tests were confirmed to be specific and suitable for titration of antirabies antibody.

  19. Benchmarks & Milestones. A Statistical Summary of Regional 2+2 Tech Prep Activities. Mt. Hood Regional Cooperative Consortium. 1992 Annual Report.

    ERIC Educational Resources Information Center

    Mount Hood Community Coll., Gresham, OR.

    This document contains seven tables and graphs that show the extent of tech prep agreements and activities for 1992, the seventh year of the Mt. Hood Regional Cooperative Consortium. The report shows that a strong cooperative relationship has been established between and among the district high schools, the education service district, and the…

  20. 32 CFR 644.8 - Planning and scheduling real estate activities.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... (CONTINUED) REAL PROPERTY REAL ESTATE HANDBOOK Project Planning Civil Works § 644.8 Planning and scheduling.... (2) It is essential that adequate funds be programmed on ENG Form 2213, Advance Engineering...

  1. Power Extension Package (PEP) system definition extension, orbital service module systems analysis study. Volume 11: PEP, cost, schedules, and work breakdown structure dictionary

    NASA Technical Reports Server (NTRS)

    1979-01-01

    Cost scheduling and funding data are presented for the reference design of the power extension package. Major schedule milestones are correlated with current Spacelab flight dates. Funding distributions provide for minimum expenditure during the first year of the project.

  2. NASA scheduling technologies

    NASA Technical Reports Server (NTRS)

    Adair, Jerry R.

    1994-01-01

    This paper is a consolidated report on ten major planning and scheduling systems that have been developed by the National Aeronautics and Space Administration (NASA). A description of each system, its components, and how it could be potentially used in private industry is provided in this paper. The planning and scheduling technology represented by the systems ranges from activity based scheduling employing artificial intelligence (AI) techniques to constraint based, iterative repair scheduling. The space related application domains in which the systems have been deployed vary from Space Shuttle monitoring during launch countdown to long term Hubble Space Telescope (HST) scheduling. This paper also describes any correlation that may exist between the work done on different planning and scheduling systems. Finally, this paper documents the lessons learned from the work and research performed in planning and scheduling technology and describes the areas where future work will be conducted.

  3. DSN Scheduling Engine

    NASA Technical Reports Server (NTRS)

    Clement, Bradley; Johnston, Mark; Wax, Allan; Chouinard, Caroline

    2008-01-01

    The DSN (Deep Space Network) Scheduling Engine targets all space missions that use DSN services. It allows clients to issue scheduling, conflict identification, conflict resolution, and status requests in XML over a Java Message Service interface. The scheduling requests may include new requirements that represent a set of tracks to be scheduled under some constraints. This program uses a heuristic local search to schedule a variety of schedule requirements, and is being infused into the Service Scheduling Assembly, a mixed-initiative scheduling application. The engine resolves conflicting schedules of resource allocation according to a range of existing and possible requirement specifications, including optional antennas; start of track and track duration ranges; periodic tracks; locks on track start, duration, and allocated antenna; MSPA (multiple spacecraft per aperture); arraying/VLBI (very long baseline interferometry)/delta DOR (differential one-way ranging); continuous tracks; segmented tracks; gap-to-track ratio; and override or block-out of requirements. The scheduling models now include conflict identification for SOA(start of activity), BOT (beginning of track), RFI (radio frequency interference), and equipment constraints. This software will search through all possible allocations while providing a best-effort solution at any time. The engine reschedules to accommodate individual emergency tracks in 0.2 second, and emergency antenna downtime in 0.2 second. The software handles doubling of one mission's track requests over one week (to 42 total) in 2.7 seconds. Further tests will be performed in the context of actual schedules.

  4. Overwintering strategy of Yunnan snub-nosed monkeys: adjustments in activity scheduling and foraging patterns.

    PubMed

    Grueter, Cyril C; Li, Dayong; Ren, Baoping; Li, Ming

    2013-04-01

    Temperate forests are characterized by pronounced climatic and phenological seasonality. Primates inhabiting such environments experience prolonged resource scarcity and low ambient temperatures in winter and are expected to adjust time allocation and foraging behavior so as to maintain their energy balance. We analyzed the activity scheduling of a group of Yunnan snub-nosed monkeys (Rhinopithecus bieti) based on data collected over 20 months in the high-altitude (>3000 m) Samage Forest, Baimaxueshan Nature Reserve, PRC. The forest consists of evergreen conifers and oaks and deciduous broadleaf trees. The diet varied seasonally, with young leaves preferentially exploited in spring and fruits in summer. The monkeys subsisted on readily available fallback resources (mainly lichens) in winter [Grueter et al. in (Am J Phys Anthropol 140:700-715, 2009)]. We predicted that this switch to a relatively low-quality diet would prompt an increase in feeding effort and decrease in moving effort. We found that the monkeys spent significantly more time feeding in winter than in the other seasons. The monthly time devoted to feeding was also negatively correlated with temperature and positively with percentage of lichens in the diet. Time spent on moving did not vary among seasons or with temperature, but day-journey length was found to be longer on hotter days. Time spent resting was lower in winter and under colder conditions and was also negatively correlated with time spent feeding, indicating that resting time is converted into feeding time during times of ecological stress. These results indicate a strong effect of seasonality on time allocation patterns, constraints on inactivity phases, and the prevalence of an energy-conserving foraging strategy in winter, when costs of thermoregulation were high and the availability of preferred food was low. PMID:23160943

  5. Overwintering strategy of Yunnan snub-nosed monkeys: adjustments in activity scheduling and foraging patterns.

    PubMed

    Grueter, Cyril C; Li, Dayong; Ren, Baoping; Li, Ming

    2013-04-01

    Temperate forests are characterized by pronounced climatic and phenological seasonality. Primates inhabiting such environments experience prolonged resource scarcity and low ambient temperatures in winter and are expected to adjust time allocation and foraging behavior so as to maintain their energy balance. We analyzed the activity scheduling of a group of Yunnan snub-nosed monkeys (Rhinopithecus bieti) based on data collected over 20 months in the high-altitude (>3000 m) Samage Forest, Baimaxueshan Nature Reserve, PRC. The forest consists of evergreen conifers and oaks and deciduous broadleaf trees. The diet varied seasonally, with young leaves preferentially exploited in spring and fruits in summer. The monkeys subsisted on readily available fallback resources (mainly lichens) in winter [Grueter et al. in (Am J Phys Anthropol 140:700-715, 2009)]. We predicted that this switch to a relatively low-quality diet would prompt an increase in feeding effort and decrease in moving effort. We found that the monkeys spent significantly more time feeding in winter than in the other seasons. The monthly time devoted to feeding was also negatively correlated with temperature and positively with percentage of lichens in the diet. Time spent on moving did not vary among seasons or with temperature, but day-journey length was found to be longer on hotter days. Time spent resting was lower in winter and under colder conditions and was also negatively correlated with time spent feeding, indicating that resting time is converted into feeding time during times of ecological stress. These results indicate a strong effect of seasonality on time allocation patterns, constraints on inactivity phases, and the prevalence of an energy-conserving foraging strategy in winter, when costs of thermoregulation were high and the availability of preferred food was low.

  6. Maternal responsiveness and children's achievement of language milestones.

    PubMed

    Tamis-LeMonda, C S; Bornstein, M H; Baumwell, L

    2001-01-01

    This prospective longitudinal study examined the contribution of dimensions of maternal responsiveness (descriptions, play, imitations) to the timing of five milestones in children's (N = 40) early expressive language: first imitations, first words, 50 words in expressive language, combinatorial speech, and the use of language to talk about the past. Events-History Analysis, a statistical technique that estimates the extent to which predictors influence the timing of events, was used. At 9 and 13 months, maternal responsiveness and children's activities (e.g., vocalizations, play) were coded from videotaped interactions of mother-child free play; information about children's language acquisition was obtained through biweekly interviews with mothers from 9 through 21 months. Maternal responsiveness at both ages predicted the timing of children's achieving language milestones over and above children's observed behaviors. Responsiveness at 13 months was a stronger predictor of the timing of language milestones than was responsiveness at 9 months, and certain dimensions of responsiveness were more predictive than others. The multidimensional nature of maternal responsiveness and specificity in mother-child language relations are discussed.

  7. 15 CFR 712.2 - Restrictions on activities involving Schedule 1 chemicals.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... § 745.1 of the Export Administration Regulations (EAR) (15 CFR parts 730 through 774). For specific... International Traffic in Arms Regulations (22 CFR parts 120 through 130) for Schedule 1 chemicals subject to the... Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL...

  8. Scheduling language and algorithm development study. Appendix: Study approach and activity summary

    NASA Technical Reports Server (NTRS)

    1974-01-01

    The approach and organization of the study to develop a high level computer programming language and a program library are presented. The algorithm and problem modeling analyses are summarized. The approach used to identify and specify the capabilities required in the basic language is described. Results of the analyses used to define specifications for the scheduling module library are presented.

  9. The range scheduling aid

    NASA Technical Reports Server (NTRS)

    Halbfinger, Eliezer M.; Smith, Barry D.

    1991-01-01

    The Air Force Space Command schedules telemetry, tracking and control activities across the Air Force Satellite Control network. The Range Scheduling Aid (RSA) is a rapid prototype combining a user-friendly, portable, graphical interface with a sophisticated object-oriented database. The RSA has been a rapid prototyping effort whose purpose is to elucidate and define suitable technology for enhancing the performance of the range schedulers. Designing a system to assist schedulers in their task and using their current techniques as well as enhancements enabled by an electronic environment, has created a continuously developing model that will serve as a standard for future range scheduling systems. The RSA system is easy to use, easily ported between platforms, fast, and provides a set of tools for the scheduler that substantially increases his productivity.

  10. What's behind Block Scheduling?

    ERIC Educational Resources Information Center

    Gierke, Carolyn

    1999-01-01

    Discussion of block scheduling in secondary schools focuses on its impact on the school library media center. Discusses increased demand for library services, scheduling classes, the impact on librarians' time, teaching information technology, local area networks, and the increased pace of activity. (LRW)

  11. Milestone M4900: Simulant Mixing Analytical Results

    SciTech Connect

    Kaplan, D.I.

    2001-07-26

    This report addresses Milestone M4900, ''Simulant Mixing Sample Analysis Results,'' and contains the data generated during the ''Mixing of Process Heels, Process Solutions, and Recycle Streams: Small-Scale Simulant'' task. The Task Technical and Quality Assurance Plan for this task is BNF-003-98-0079A. A report with a narrative description and discussion of the data will be issued separately.

  12. Milestones in Cancer Research and Discovery

    Cancer.gov

    During the past 250 years, we have witnessed many landmark discoveries in our efforts to make progress against cancer, an affliction known to humanity for thousands of years. This timeline shows a few key milestones in the history of cancer research.

  13. 14 CFR 1274.908 - Milestone payments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Milestone payments. 1274.908 Section 1274.908 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION COOPERATIVE AGREEMENTS WITH... cooperative agreement. (ix) Taxpayer identification number (TIN). (x) While not required, the recipient...

  14. 14 CFR 1274.908 - Milestone payments.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Milestone payments. 1274.908 Section 1274.908 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION COOPERATIVE AGREEMENTS WITH... cooperative agreement. (ix) Taxpayer identification number (TIN). (x) While not required, the recipient...

  15. 47 CFR 25.164 - Milestones.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Milestones. (a) Licensees of geostationary orbit satellite systems other than DBS and DARS satellite systems.... (b) Licensees of non-geostationary orbit satellite systems other than DBS and DARS satellite systems... both non-geostationary orbit satellites and geostationary orbit satellites, other than DBS and...

  16. 47 CFR 25.164 - Milestones.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Milestones. (a) Licensees of geostationary orbit satellite systems other than DBS and DARS satellite systems.... (b) Licensees of non-geostationary orbit satellite systems other than DBS and DARS satellite systems... both non-geostationary orbit satellites and geostationary orbit satellites, other than DBS and...

  17. 47 CFR 25.164 - Milestones.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Milestones. (a) Licensees of geostationary orbit satellite systems other than DBS and DARS satellite systems.... (b) Licensees of non-geostationary orbit satellite systems other than DBS and DARS satellite systems... both non-geostationary orbit satellites and geostationary orbit satellites, other than DBS and...

  18. 47 CFR 25.164 - Milestones.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Milestones. (a) Licensees of geostationary orbit satellite systems other than DBS and DARS satellite systems.... (b) Licensees of non-geostationary orbit satellite systems other than DBS and DARS satellite systems... both non-geostationary orbit satellites and geostationary orbit satellites, other than DBS and...

  19. Developmental Milestones in Toddlers with Atypical Development

    ERIC Educational Resources Information Center

    Horovitz, Max; Matson, Johnny L.

    2011-01-01

    The attainment of developmental milestones was examined and compared in 162 infants and toddlers with developmental disabilities, including Down Syndrome (n = 26), Cerebral Palsy (n = 19), Global Developmental Delay (n = 22), Premature birth (n = 66), and Seizure Disorder (n = 29). Toddlers in the Seizures Disorder group began crawling at a…

  20. Self-Perceived Milestones in Aging.

    ERIC Educational Resources Information Center

    Meyer, Ann Jane

    Theorists and researchers have developed abstract divisions in the life span to mark significant stages. To explore the conceptual labels individuals use to make divisions in their life spans, 92 adults, aged 20 to 55 years, marked significant milestones on a lifeline. Participants also completed a demographic questionnaire. Data on the labels…

  1. Multi-day activity scheduling reactions to planned activities and future events in a dynamic model of activity-travel behavior

    NASA Astrophysics Data System (ADS)

    Nijland, Linda; Arentze, Theo; Timmermans, Harry

    2014-01-01

    Modeling multi-day planning has received scarce attention in activity-based transport demand modeling so far. However, new dynamic activity-based approaches are being developed at the current moment. The frequency and inflexibility of planned activities and events in activity schedules of individuals indicate the importance of incorporating those pre-planned activities in the new generation of dynamic travel demand models. Elaborating and combining previous work on event-driven activity generation, the aim of this paper is to develop and illustrate an extension of a need-based model of activity generation that takes into account possible influences of pre-planned activities and events. This paper describes the theory and shows the results of simulations of the extension. The simulation was conducted for six different activities, and the parameter values used were consistent with an earlier estimation study. The results show that the model works well and that the influences of the parameters are consistent, logical, and have clear interpretations. These findings offer further evidence of face and construct validity to the suggested modeling approach.

  2. 10 CFR 603.1105 - Advance payments or payable milestones.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Advance payments or payable milestones. 603.1105 Section 603.1105 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS TECHNOLOGY INVESTMENT... projected budget for completing the milestone; and (2) Adjust future payable milestones, as needed,...

  3. 10 CFR 603.1105 - Advance payments or payable milestones.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Advance payments or payable milestones. 603.1105 Section 603.1105 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS TECHNOLOGY INVESTMENT... projected budget for completing the milestone; and (2) Adjust future payable milestones, as needed,...

  4. 10 CFR 603.1105 - Advance payments or payable milestones.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Advance payments or payable milestones. 603.1105 Section 603.1105 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS TECHNOLOGY INVESTMENT... projected budget for completing the milestone; and (2) Adjust future payable milestones, as needed,...

  5. 10 CFR 603.1105 - Advance payments or payable milestones.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Advance payments or payable milestones. 603.1105 Section 603.1105 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS TECHNOLOGY INVESTMENT... projected budget for completing the milestone; and (2) Adjust future payable milestones, as needed,...

  6. 10 CFR 603.1105 - Advance payments or payable milestones.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Advance payments or payable milestones. 603.1105 Section 603.1105 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS TECHNOLOGY INVESTMENT... projected budget for completing the milestone; and (2) Adjust future payable milestones, as needed,...

  7. Milestones Toward Majorana-Based Quantum Computing

    NASA Astrophysics Data System (ADS)

    Aasen, David; Hell, Michael; Mishmash, Ryan V.; Higginbotham, Andrew; Danon, Jeroen; Leijnse, Martin; Jespersen, Thomas S.; Folk, Joshua A.; Marcus, Charles M.; Flensberg, Karsten; Alicea, Jason

    2016-07-01

    We introduce a scheme for preparation, manipulation, and read out of Majorana zero modes in semiconducting wires with mesoscopic superconducting islands. Our approach synthesizes recent advances in materials growth with tools commonly used in quantum-dot experiments, including gate control of tunnel barriers and Coulomb effects, charge sensing, and charge pumping. We outline a sequence of milestones interpolating between zero-mode detection and quantum computing that includes (1) detection of fusion rules for non-Abelian anyons using either proximal charge sensors or pumped current, (2) validation of a prototype topological qubit, and (3) demonstration of non-Abelian statistics by braiding in a branched geometry. The first two milestones require only a single wire with two islands, and additionally enable sensitive measurements of the system's excitation gap, quasiparticle poisoning rates, residual Majorana zero-mode splittings, and topological-qubit coherence times. These pre-braiding experiments can be adapted to other manipulation and read out schemes as well.

  8. DSN Resource Scheduling

    NASA Technical Reports Server (NTRS)

    Wang, Yeou-Fang; Baldwin, John

    2007-01-01

    TIGRAS is client-side software, which provides tracking-station equipment planning, allocation, and scheduling services to the DSMS (Deep Space Mission System). TIGRAS provides functions for schedulers to coordinate the DSN (Deep Space Network) antenna usage time and to resolve the resource usage conflicts among tracking passes, antenna calibrations, maintenance, and system testing activities. TIGRAS provides a fully integrated multi-pane graphical user interface for all scheduling operations. This is a great improvement over the legacy VAX VMS command line user interface. TIGRAS has the capability to handle all DSN resource scheduling aspects from long-range to real time. TIGRAS assists NASA mission operations for DSN tracking of station equipment resource request processes from long-range load forecasts (ten years or longer), to midrange, short-range, and real-time (less than one week) emergency tracking plan changes. TIGRAS can be operated by NASA mission operations worldwide to make schedule requests for the DSN station equipment.

  9. The Effects of the Mars Exploration Rovers (MER) Work Schedule Regime on Locomotor Activity Circadian Rhythms, Sleep and Fatigue

    NASA Technical Reports Server (NTRS)

    DeRoshia, Charles W.; Colletti, Laura C.; Mallis, Melissa M.

    2008-01-01

    This study assessed human adaptation to a Mars sol by evaluating sleep metrics obtained by actigraphy and subjective responses in 22 participants, and circadian rhythmicity in locomotor activity in 9 participants assigned to Mars Exploration Rover (MER) operational work schedules (24.65 hour days) at the Jet Propulsion Laboratory in 2004. During MER operations, increased work shift durations and reduced sleep durations and time in bed were associated with the appearance of pronounced 12-hr (circasemidian) rhythms with reduced activity levels. Sleep duration, workload, and circadian rhythm stability have important implications for adaptability and maintenance of operational performance not only of MER operations personnel but also in space crews exposed to a Mars sol of 24.65 hours during future Mars missions.

  10. New recommended schedule for active immunization of normal infants and children.

    PubMed

    1986-09-19

    A large, randomized, double-blind trial has made available sufficient data to recommend the simultaneous administration of combined measles-mumps-rubella (MMR), diphtheria and tetanus toxoids and pertussis (DTP), and oral poliovirus (OPV) vaccines to all children 15 months old or older who are eligible to receive these vaccines. In this trial, serologic response and clinical reaction rates following primary immunization with MMR were compared in a test group of 405 children given MMR simultaneously with DTP and OPV and a control group of 410 children given MMR followed by doses of DTP and OPV vaccine 2 months later. Seroconversion rates to each MMR component exceeded 96% in both groups, and the geometric mean titers achieved against the other 6 antigens also were similar in both groups. Rates of most of the common vaccine-associated clinical reactions to DTP and MMR were not augmented by simultaneous administration of these 2 vaccines. Some minor side effects were reported more frequently in the simultaneous-administration group, but these difference were judged to be related to artifacts of the study design rather than to differences in the safety of the 2 vaccine schedules. Data from the Center for Disease Control's Monitoring System for Adverse Events Following Immunization have been reviewed, particularly the information from Idaho, Louisiana, and Tennessee, where policies to administer MMR, DTP, and OPV simultaneously have been in effect for periods ranging from several months to years. The evidence suggests no increased risk of reactions associated with the simulaneous administration of these antigens. The overall implications of simultaneous administartion have not been fully defined, but it is anticipated that implementation of this new schedule will result in at least 3 benefits: a decrease in the number of health care provider visits required for immunization during the 2nd year of life, and accompanying decrease in costs, and an increase in the

  11. 2014 Report on the Milestones for the US National Plan to Address Alzheimer's Disease.

    PubMed

    Fargo, Keith N; Aisen, Paul; Albert, Marilyn; Au, Rhoda; Corrada, Maria M; DeKosky, Steven; Drachman, David; Fillit, Howard; Gitlin, Laura; Haas, Magali; Herrup, Karl; Kawas, Claudia; Khachaturian, Ara S; Khachaturian, Zaven S; Klunk, William; Knopman, David; Kukull, Walter A; Lamb, Bruce; Logsdon, Rebecca G; Maruff, Paul; Mesulam, Marsel; Mobley, William; Mohs, Richard; Morgan, David; Nixon, Ralph A; Paul, Steven; Petersen, Ronald; Plassman, Brenda; Potter, William; Reiman, Eric; Reisberg, Barry; Sano, Mary; Schindler, Rachel; Schneider, Lon S; Snyder, Peter J; Sperling, Reisa A; Yaffe, Kristine; Bain, Lisa J; Thies, William H; Carrillo, Maria C

    2014-10-01

    With increasing numbers of people with Alzheimer's and other dementias across the globe, many countries have developed national plans to deal with the resulting challenges. In the United States, the National Alzheimer's Project Act, signed into law in 2011, required the creation of such a plan with annual updates thereafter. Pursuant to this, the US Department of Health and Human Services (HHS) released the National Plan to Address Alzheimer's Disease in 2012, including an ambitious research goal of preventing and effectively treating Alzheimer's disease by 2025. To guide investments, activities, and the measurement of progress toward achieving this 2025 goal, in its first annual plan update (2013) HHS also incorporated into the plan a set of short, medium and long-term milestones. HHS further committed to updating these milestones on an ongoing basis to account for progress and setbacks, and emerging opportunities and obstacles. To assist HHS as it updates these milestones, the Alzheimer's Association convened a National Plan Milestone Workgroup consisting of scientific experts representing all areas of Alzheimer's and dementia research. The workgroup evaluated each milestone and made recommendations to ensure that they collectively constitute an adequate work plan for reaching the goal of preventing and effectively treating Alzheimer's by 2025. This report presents these Workgroup recommendations.

  12. Hanford Site Environmental Surveillance Master Sampling Schedule for Calendar Year 2006

    SciTech Connect

    Bisping, Lynn E.

    2006-01-27

    This document contains the calendar year 2006 schedules for the routine and non-routine collection of samples for the Surface Environmental Surveillance Project (SESP) and Drinking Water Monitoring Project. Each section includes sampling locations, sample types, and analyses to be performed. In some cases, samples are scheduled on a rotating basis and may not be collected in 2006 in which case the anticipated year for collection is provided. The project document package (PDP) for Surface Environmental Surveillance contains the milestone control log for the issuing of CY06 Environmental Surveillance Master Sampling Schedule WBS 4.2.3.21.3.03, milestone: RL00430306 (4830106-12).

  13. Predicting real-world functional milestones in schizophrenia.

    PubMed

    Olsson, Anna-Karin; Hjärthag, Fredrik; Helldin, Lars

    2016-08-30

    Schizophrenia is a severe disorder that often causes impairments in major areas of functioning, and most patients do not achieve expected real-world functional milestones. The aim of this study was to identify which variables of demography, illness activity, and functional capacity predict patients' ability to attain real-world functional milestones. Participants were 235 outpatients, 149 men and 86 women, diagnosed with schizophrenia spectrum disorder. Our results showed that younger patients managed to achieve a higher level of functioning in educational level, marital status, and social contacts. Patients' functional capacity was primarily associated with educational level and housing situation. We also found that women needed less support regarding housing and obtained a higher level of marital status as compared with men. Our findings demonstrate the importance of considering current symptoms, especially negative symptoms, and remission stability over time, together with age, duration of illness, gender, educational level, and current functional capacity, when predicting patients' future real-world functioning. We also conclude that there is an advantage in exploring symptoms divided into positive, negative, and general domains considering their probable impact on functional achievements.

  14. Construction Milestone Announced on Green Bank Telescope

    NASA Astrophysics Data System (ADS)

    2000-04-01

    The National Radio Astronomy Observatory announces completion of a major construction milestone on the world's largest fully steerable radio telescope - the National Science Foundation's Green Bank Telescope (GBT). The last of 2,004 aluminum surface panels was recently installed on the GBT's two-acre (100 m x 110 m) collecting dish. The telescope is located at NRAO's Green Bank site, in rural Pocahontas County, West Virginia. The GBT will be used to study everything from the formation of galaxies in the early universe, to the chemical make-up of the dust and gas inside galaxies and in the voids that separate them, to the birth processes of stars. In conjunction with other instruments, it will help make highly accurate radar maps of some familiar objects in our own solar system. The GBT is an engineering marvel. At 485 feet tall, it is comparable in height to the Washington Monument. It weighs 16 million pounds, yet by swiveling the dish in both azimuth and elevation, it can be pointed to any point in the sky with exquisite accuracy. Additionally, the telescope's two-acre collecting dish has many novel features. Most radio telescopes in use today use receivers suspended above the dish by four struts. These struts block some of the surface of the dish, scattering some of the incoming radio waves from celestial objects under study. The GBT's offset feedarm has no struts to block incoming radio waves. The GBT also boasts an active surface. The surface of the dish is composed of 2,004 panels. On the underside of the dish, actuators are located at each corner (i.e., intersection of four panels). These actuators are motors that move the surface panels up and down, keeping the (paraboloid) shape of the dish precisely adjusted, no matter what the tilt of the telescope. The combination of its unblocked aperture and active surface promise that the GBT will display extremely high sensitivity to faint radio signals. The GBT itself is not the only precious national resource in

  15. Mission scheduling

    NASA Technical Reports Server (NTRS)

    Gaspin, Christine

    1989-01-01

    How a neural network can work, compared to a hybrid system based on an operations research and artificial intelligence approach, is investigated through a mission scheduling problem. The characteristic features of each system are discussed.

  16. Level-2 Milestone 5213. CTS-1 Contract Award Completed

    SciTech Connect

    Leininger, Matt

    2015-09-24

    This report documents the fact that the first commodity technology (CT) system contract award, CTS-1, has been completed. The description of the milestone is: Based on Tri-Lab CTS-1 process and review, LLNL successfully awards the procurement for the next-generation Tri-Lab Linux CTS-1. The milestone completion criterion is: Signed contract. The milestone was completed on September 24th. 2015.

  17. 18. INTERIOR OF CIVIL RIGHTS INSTITUTE, MILESTONE GALLERY EXHIBITION OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    18. INTERIOR OF CIVIL RIGHTS INSTITUTE, MILESTONE GALLERY EXHIBITION OF THE SIXTEENTH STREET CHURCH, LOOKING NORTHWEST - Sixteenth Street Baptist Church, 1530 Sixth Avenue North, Birmingham, Jefferson County, AL

  18. Effects of a Photo Activity Schedule Book on Independent Task Changes by Students with Intellectual Disabilities in Community and School Job Sites

    ERIC Educational Resources Information Center

    Carson, Keyla D; Gast, David L.; Ayres, Kevin M.

    2008-01-01

    The purpose of this study was to evaluate the effectiveness of using a photo activity schedule book to increase independent transitioning between vocational tasks inside a school cafeteria and at a community job site. Three students with mild to moderate intellectual disabilities, enrolled in a self-contained classroom in a public high school,…

  19. The Effects of a Picture Activity Schedule for Students with Intellectual Disability to Complete a Sequence of Tasks Following Verbal Directions

    ERIC Educational Resources Information Center

    Duttlinger, Cari; Ayres, Kevin M.; Bevill-Davis, Alicia; Douglas, Karen H.

    2013-01-01

    We investigated instruction of independent creation of picture activity schedules (PASs) and how four middle school students with intellectual disability used them to complete tasks independently. A withdrawal design (A-BC-B-A-B) was used to evaluate whether the intervention had an effect on the dependent variable and to test for generalization to…

  20. Milestones and Experiences of Standardized Documentation.

    PubMed

    Saranto, Kaija; Saba, Virginia; Dykes, Patricia; Kinnunen, Ulla-Mari; Mykkänen, Minna

    2016-01-01

    The purpose of this panel is to discuss milestones and experiences of a standardized nursing terminology for the documentation of nursing practice using Clinical Care Classification as an example. The aim is to describe the value of using the CCC as the standardized nursing terminology and framework for the multidisciplinary care plans and how its interoperability with SNOMED CT, LOINC, and other required terminologies can be used for the electronic health record systems. Further the aim is to discuss the advantages a multidisciplinary documentation system and how it impacts on nursing practice, management, and research as well as highlight the monitoring of nursing documentation. The target audience will enrich their understanding about the possibilities that a standardized multidisciplinary documentation is critical for future data analyses and datamining highlighting nursing practices. PMID:27332328

  1. Milestones in the history of personality disorders.

    PubMed

    Crocq, Marc-Antoine

    2013-06-01

    This paper analyzes the major historical milestones in the study of normal and abnormal personality, from antiquity up until the 20th century. Special attention is paid to the interaction between dimensional and typological approaches, which was a major issue during the preparation of DSM-5. Theories of personality started with the humoral theory of Greek medicine. Pinel, and later Esquirol and Prichard, are credited with the first descriptions of abnormal personalities in textbooks of psychiatry. Between the late 19th and early 20th centuries, elaborate systems of normal and abnormal personality, associating to some degree types and dimensions, were devised by a succession of European psychologists, such as Ribot, Heymans, and Lazursky. Emil Kraepelin and Kurt Schneider proposed classifications of abnormal personality types. In parallel, psychoanalysts stressed the role of early life experiences. Towards the mid-20th century, statistical methods were applied to the scientific validation of personality dimensions with pioneers such as Cattell, anticipating the five-factor model.

  2. Artificial insemination history: hurdles and milestones.

    PubMed

    Ombelet, W; Van Robays, J

    2015-01-01

    Artificial insemination with homologous (AIH) or donor semen (AID) is nowadays a very popular treatment procedure used for many subfertile women worldwide. The rationale behind artificial insemination is to increase gamete density at the site of fertilisation. The sequence of events leading to today's common use of artificial insemination traces back to scientific studies and experimentation many centuries ago. Modern techniques used in human artificial insemination programmes are mostly adapted from the work on cattle by dairy farmers wishing to improve milk production by using artificial insemination with sperm of selected bulls with well chosen genetic traits. The main reason for the renewed interest in artificial insemination in human was associated with the refinement of techniques for the preparation of washed motile spermatozoa in the early years of IVF. The history of artificial insemination is reviewed with particular interest to the most important hurdles and milestones. PMID:26175891

  3. Artificial insemination history: hurdles and milestones

    PubMed Central

    Ombelet, W.; Van Robays, J.

    2015-01-01

    Artificial insemination with homologous (AIH) or donor semen (AID) is nowadays a very popular treatment procedure used for many subfertile women worldwide. The rationale behind artificial insemination is to increase gamete density at the site of fertilisation. The sequence of events leading to today’s common use of artificial insemination traces back to scientific studies and experimentation many centuries ago. Modern techniques used in human artificial insemination programmes are mostly adapted from the work on cattle by dairy farmers wishing to improve milk production by using artificial insemination with sperm of selected bulls with well chosen genetic traits. The main reason for the renewed interest in artificial insemination in human was associated with the refinement of techniques for the preparation of washed motile spermatozoa in the early years of IVF. The history of artificial insemination is reviewed with particular interest to the most important hurdles and milestones. PMID:26175891

  4. Nicotine withdrawal: a behavioral assessment using schedule controlled responding, locomotor activity, and sensorimotor reactivity.

    PubMed

    Helton, D R; Modlin, D L; Tizzano, J P; Rasmussen, K

    1993-01-01

    Three different behavioral measures were used to assess the effects of abrupt cessation of chronic nicotine treatment. Nicotine (0, 3, or 6 mg/kg per day) was continuously administered for 12 days in rats by surgically implanting Alzet osmotic mini-pumps subcutaneously. Experiment 1 employed a light/dark discrimination task. There were no significant effects on number of responses or percent correct responding either during nicotine administration, or following cessation of nicotine. Experiment 2 examined ambulatory (locomotor) and nonambulatory activity. Chronic nicotine administration produced significant dose-dependent increases in both ambulatory and nonambulatory activity during the first 3 days of exposure. However, no significant alterations were seen in activity levels following nicotine cessation. Experiment 3 examined sensorimotor reactivity using the auditory startle response. During nicotine withdrawal, significant increases were seen in startle amplitude in both nicotine groups for 4 days. Nicotine (0.4 mg/kg, IP) administered before startle testing during the withdrawal phase attenuated the increased reactivity seen during nicotine cessation. These studies indicate that 1) rats display increased sensorimotor reactivity after cessation of chronic nicotine exposure, and 2) the expression of nicotine dependence and withdrawal is dependent on the behavioral task employed. PMID:7855182

  5. 43 CFR 3930.30 - Diligent development milestones.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Diligent development milestones. 3930.30... Management of Oil Shale Exploration Licenses and Leases § 3930.30 Diligent development milestones. (a... lease, POD, and these regulations. If the operator does not maintain or comply with diligent...

  6. An examination of the effects of a classroom activity schedule on levels of self-injury and engagement for a child with severe autism.

    PubMed

    O'Reilly, Mark; Sigafoos, Jeff; Lancioni, Giulio; Edrisinha, Chaturi; Andrews, Alonzo

    2005-06-01

    We examined the effects of an individualized schedule on levels of engagement and self-injury for a student with severe autism. We first conducted a series of functional analyses to identify contexts in which self-injury occurred in his classroom. Results of the functional analyses suggested that self-injury was associated with academic demands. Self-injury rarely occurred during the play and no interaction conditions (i.e., when the teacher was present but did not attend to him) of the functional analysis. Furthermore, when the functional analysis conditions were organized according to a specific schedule (no interaction-play-demand) self-injury did not occur. This schedule of activities was then evaluated within the context of his regular curriculum and produced substantial reductions in self-injury and increases in engagement. Positive results maintained for up to five months following the assessment. These findings seem to indicate that functional analysis methodologies might provide helpful information when developing individualized schedules for students who may not have the skills to comprehend and follow a schedule.

  7. Age-aware solder performance models : level 2 milestone completion.

    SciTech Connect

    Neilsen, Michael K.; Vianco, Paul Thomas; Neidigk, Matthew Aaron; Holm, Elizabeth Ann

    2010-09-01

    Legislated requirements and industry standards are replacing eutectic lead-tin (Pb-Sn) solders with lead-free (Pb-free) solders in future component designs and in replacements and retrofits. Since Pb-free solders have not yet seen service for long periods, their long-term behavior is poorly characterized. Because understanding the reliability of Pb-free solders is critical to supporting the next generation of circuit board designs, it is imperative that we develop, validate and exercise a solder lifetime model that can capture the thermomechanical response of Pb-free solder joints in stockpile components. To this end, an ASC Level 2 milestone was identified for fiscal year 2010: Milestone 3605: Utilize experimentally validated constitutive model for lead-free solder to simulate aging and reliability of solder joints in stockpile components. This report documents the completion of this milestone, including evidence that the milestone completion criteria were met and a summary of the milestone Program Review.

  8. Campaign 2 Level 2 Milestone Review 2009: Milestone # 3131 Grain Scale Simulation of Pore Collapse

    SciTech Connect

    Schwartz, A J

    2009-09-28

    The milestone reviewed on Sept. 16, 2009 was 'High-fidelity simulation of shock initiation of high explosives at the grain scale using coupled hydrodynamics, thermal transport and chemistry'. It is the opinion of the committee that the team has satisfied the milestone. A detailed description of how the goals were met is provided. The milestone leveraged capabilities from ASC Physics and Engineering Materials program combined with experimental input from Campaign 2. A combined experimental-multiscale simulation approach was used to create and validate the various TATB model components. At the lowest length scale, quantum chemical calculations were used to determine equations of state, thermal transport properties and reaction rates for TATB as it is decomposing. High-pressure experiments conducted in diamond anvil cells, gas guns and the Z machine were used to validate the EOS, thermal conductivity, specific heat and predictions of water formation. The predicted reaction networks and chemical kinetic equations were implemented in Cheetah and validated against the lower length scale data. Cheetah was then used within the ASC code ALE3D for high-resolution, thermo-mechanically coupled simulations of pore collapse at the micron size scale to predict conditions for detonation initiation.

  9. Certification of Completion of ASC FY08 Level-2 Milestone ID #2933

    SciTech Connect

    Lipari, D A

    2008-06-12

    This report documents the satisfaction of the completion criteria associated with ASC FY08 Milestone ID No.2933: 'Deploy Moab resource management services on BlueGene/L'. Specifically, this milestone represents LLNL efforts to enhance both SLURM and Moab to extend Moab's capabilities to schedule and manage BlueGene/L, and increases portability of user scripts between ASC systems. The completion criteria for the milestone are the following: (1) Batch jobs can be specified, submitted to Moab, scheduled and run on the BlueGene/L system; (2) Moab will be able to support the markedly increased scale in node count as well as the wiring geometry that is unique to BlueGene/L; and (3) Moab will also prepare and report statistics of job CPU usage just as it does for the current systems it supports. This document presents the completion evidence for both of the stated milestone certification methods: Completion evidence for this milestone will be in the form of (1) documentation--a report that certifies that the completion criteria have been met; and (2) user hand-off. As the selected Tri-Lab workload manager, Moab was chosen to replace LCRM as the enterprise-wide scheduler across Livermore Computing (LC) systems. While LCRM/SLURM successfully scheduled jobs on BG/L, the effort to replace LCRM with Moab on BG/L represented a significant challenge. Moab is a commercial product developed and sold by Cluster Resources, Inc. (CRI). Moab receives the users batch job requests and dispatches these jobs to run on a specific cluster. SLURM is an open-source resource manager whose development is managed by members of the Integrated Computational Resource Management Group (ICRMG) within the Services and Development Division at LLNL. SLURM is responsible for launching and running jobs on an individual cluster. Replacing LCRM with Moab on BG/L required substantial changes to both Moab and SLURM. While the ICRMG could directly manage the SLURM development effort, the work to enhance Moab

  10. The role of physical activity and feeding schedule on the kinetics of inhaled and oral toluene in rats.

    PubMed

    Bushnell, Philip J; Oshiro, Wendy M; Samsam, Tracey E; Klinger, Robert

    2007-11-01

    Published studies of the kinetics of toluene in rats have shown that its concentration in the blood rises during inhalation and falls after exposure stops; a similar uptake profile and longer persistence in blood typify the kinetics after oral exposure. Because rats in these studies are typically inactive during exposure, and behavioral tests of the acute effects of toluene require physical activity and altered feeding schedules, this study examined the role of physical activity and feeding status on the uptake of toluene given by the two routes. Two groups of adult male Long-Evans rats were conditioned to eat in the lab during the day. A group of "conditioned-active" (C-A) rats performed a lever-pressing task (LPT) for 1 h, either while inhaling toluene vapor (2000 ppm) or after a gavage dose (800 mg/kg toluene in corn oil). Another group of "conditioned-sedentary" (C-S) rats was dosed similarly but did not perform the LPT. A third group of "home cage" (HC) rats was not conditioned to eat during the day, but was maintained under typical laboratory conditions (eating at night in the home cage) before receiving toluene by gavage. In the conditioned rats, physical activity during inhalation exposure increased the concentrations of toluene in blood (from 35.8 +/- 2.5 to 45.2 +/- 3.2 mg/L after 60 min) and brain (from 73.4 +/- 5.3 to 103.0 +/- 3.8 mg/L after 60 min), but did not affect those concentrations after oral toluene. The time course of the uptake of toluene into blood and brain of HC rats followed that of published data. In contrast, toluene concentrations in the blood and brain of orally dosed conditioned rats fell rapidly compared to HC rats and published data (at 60 min after dosing, blood concentrations were: C-S rats, 17.2 +/- 1.7 mg/L; HC rats, 69.4 +/- 9.6 mg/L; and brain concentrations were: C-S rats, 30.9 +/- 5.0 mg/L; HC rats, 96.6 +/- 18.5 mg/L). These studies demonstrate the importance of physical activity for the uptake of inhaled toluene, and the

  11. Milestones in the history of personality disorders

    PubMed Central

    Crocq, Marc-Antoine

    2013-01-01

    This paper analyzes the major historical milestones in the study of normal and abnormal personality, from antiquity up until the 20th century. Special attention is paid to the interaction between dimensional and typological approaches, which was a major issue during the preparation of DSM-5. Theories of personality started with the humoral theory of Greek medicine. Pinel, and later Esquirol and Prichard, are credited with the first descriptions of abnormal personalities in textbooks of psychiatry. Between the late 19th and early 20th centuries, elaborate systems of normal and abnormal personality, associating to some degree types and dimensions, were devised by a succession of European psychologists, such as Ribot, Heymans, and Lazursky. Emil Kraepelin and Kurt Schneider proposed classifications of abnormal personality types. In parallel, psychoanalysts stressed the role of early life experiences. Towards the mid-20th century, statistical methods were applied to the scientific validation of personality dimensions with pioneers such as Cattell, anticipating the five-factor model. PMID:24174889

  12. ASC Trilab L2 Codesign Milestone 2015

    SciTech Connect

    Trott, Christian Robert; Hammond, Simon David; Dinge, Dennis; Lin, Paul T.; Vaughan, Courtenay T.; Cook, Jeanine; Edwards, Harold C.; Rajan, Mahesh; Hoekstra, Robert J.

    2015-09-01

    For the FY15 ASC L2 Trilab Codesign milestone Sandia National Laboratories performed two main studies. The first study investigated three topics (performance, cross-platform portability and programmer productivity) when using OpenMP directives and the RAJA and Kokkos programming models available from LLNL and SNL respectively. The focus of this first study was the LULESH mini-application developed and maintained by LLNL. In the coming sections of the report the reader will find performance comparisons (and a demonstration of portability) for a variety of mini-application implementations produced during this study with varying levels of optimization. Of note is that the implementations utilized including optimizations across a number of programming models to help ensure claims that Kokkos can provide native-class application performance are valid. The second study performed during FY15 is a performance assessment of the MiniAero mini-application developed by Sandia. This mini-application was developed by the SIERRA Thermal-Fluid team at Sandia for the purposes of learning the Kokkos programming model and so is available in only a single implementation. For this report we studied its performance and scaling on a number of machines with the intent of providing insight into potential performance issues that may be experienced when similar algorithms are deployed on the forthcoming Trinity ASC ATS platform.

  13. Epidemiology of child psychopathology: major milestones.

    PubMed

    Verhulst, Frank C; Tiemeier, Henning

    2015-06-01

    Child psychiatric epidemiology has developed rapidly from descriptive, cross-sectional studies in the 1960s to the current large-scale prospective cohorts that unravel aetiological mechanisms. The objective of the study was to give an overview of epidemiological studies that have influenced child psychiatry. A chronological overview of selected major milestone studies was obtained to demonstrate the development of child psychiatric epidemiology, with a more in-depth discussion of findings and methodological issues exemplified in one cohort, the Generation R Study. Epidemiological studies have been successful in describing the frequency and course of child psychiatric problems. The high expectations that biological factors can be used to better explain, diagnose or predict child psychiatric problems have not been met. More ambitious large-scale child psychiatric cohort studies are needed, carefully applying genetics, neuroscience or other molecular research to better understand how the brain produces maladaptive behaviour. Progress will only be attained if the basic sciences are systematically integrated in cohorts with rigorous epidemiological designs rather than hurriedly inserted in child psychiatric studies.

  14. Influence of feeding schedules on the chronobiology of renin activity, urinary electrolytes and blood pressure in dogs.

    PubMed

    Mochel, Jonathan P; Fink, Martin; Bon, Charlotte; Peyrou, Mathieu; Bieth, Bruno; Desevaux, Cyril; Deurinck, Mark; Giraudel, Jérôme M; Danhof, Meindert

    2014-06-01

    The contribution of the renin-angiotensin-aldosterone system (RAAS) to the development of congestive heart failure (CHF) and hypertension (HT) has long been recognized. Medications that are commonly used in the course of CHF and HT are most often given with morning food for the sake of convenience and therapeutic compliance. However, biological rhythms and their responsiveness to environmental clues such as food intake may noticeably impact the effectiveness of drugs used in the management of cardiovascular disorders. Only sparse information about the effect of feeding schedules on the biology of the RAAS and blood pressure (BP) is presently available. Two studies were designed to explore the chronobiology of renin activity (RA), BP, renal sodium (UNa,fe) and potassium (UK,fe) handling in relation to meal timing in dogs. In a first experiment (Study a), blood and urinary samples for measurement of RA, UNa,fe and UK,fe were drawn from 18 healthy beagle dogs fed a normal-sodium diet at either 07:00, 13:00 or 19:00 h. In a second experiment (Study b), BP was recorded continuously from six healthy, telemetered beagle dogs fed a similar diet at 07:00, or 19:00 h. Data were collected throughout 24-h time periods, and analyzed by means of nonlinear mixed-effects models. Differences between the geometric means of early versus late time after feeding observations were further compared using parametric statistics. In agreement with our previous investigations, the results indicate that RA, UNa,fe, UK,fe, systolic, and diastolic BP oscillate with a circadian periodicity in dogs fed a regular diet at 07:00 h. A cosine model with a fixed 24-h period was found to fit the variations of RA, UK,fe and BP well, whereas cyclic changes in UNa,fe were best characterized by means of a combined cosine and surge model, reflecting a postprandial sodium excretion followed by a monotonous decay. Our data show that feeding time has a marked influence on the chronobiology of the renin

  15. Associations among correlates of schedule adherence to antiretroviral therapy (ART): a path analysis of a sample of crack cocaine using sexually active African-Americans with HIV infection.

    PubMed

    Atkinson, J S; Schönnesson, L Nilsson; Williams, M L; Timpson, S C

    2008-02-01

    Adherence to HIV medication regimens is a function of multiple dimensions including psychological functioning, social support, adherence self-efficacy and optimism regarding treatment. Active substance use can also negatively affect adherence. An understanding of the nature of the associations among the correlates of adherence can better inform the design of interventions to improve adherence. This study developed an exploratory path model of schedule adherence using data from a sample 130 African-American HIV-positive crack cocaine users on highly active antiretroviral therapy (ART). This model was based on the Transactional Model of Stress and Coping developed by Lazarus and Folkman. Following the theory, the effects of psychological distress on schedule adherence were mediated by patients' relationship with their doctor and optimism towards antiretroviral treatment. Adherence was also associated with patients' self-efficacy regarding their medical regimen which, in turn, was associated with their social support.

  16. Hydrogen milestone could help lower fossil fuel refining costs

    ScienceCinema

    Stephen Herring

    2016-07-12

    Hydrogen researchers at the U.S. Department of Energy's Idaho National Laboratory have reached another milestone on the road to reducing carbon emissions and protecting the nation against the effects of peaking world oil production. Stephen Herring, lab

  17. Those Baby 'Milestones' May Have Longer-Term Importance

    MedlinePlus

    ... an important basis for various aspects of later child development." The research team -- led by Edwina Yeung, of ... and underweight. Those are key factors in a child's development, and might "overshadow" any link between movement milestones ...

  18. Hydrogen milestone could help lower fossil fuel refining costs

    SciTech Connect

    Stephen Herring

    2009-10-13

    Hydrogen researchers at the U.S. Department of Energy's Idaho National Laboratory have reached another milestone on the road to reducing carbon emissions and protecting the nation against the effects of peaking world oil production. Stephen Herring, lab

  19. Detailed leak detection test plan and schedule for the Oak Ridge National Laboratory LLLW active tanks. Waste Management and Environmental Restoration Programs

    SciTech Connect

    Douglas, D.G.; Maresca, J.W. Jr.

    1993-03-01

    This document provides a detailed leak detection test plan and schedule for leak testing many of the tanks that comprise the active portion of the liquid low-level waste (LLLW) system at the Oak Ridge National Laboratory (ORNL). This plan was prepared in response to the requirements of the Federal Facility Agreement (FFA) between the US Department of Energy (DOE) and two other agencies, the US Environmental Protection Agency (EPA) and the Tennessee Department of Environment and Conservation (TDEC).

  20. A brief history of hepatitis milestones.

    PubMed

    Trepo, Christian

    2014-02-01

    Hepatitis has been a major plague of mankind. The history of the discovery of causative viruses is one of the most fascinating scientific adventures of this half century. Individualization of several types of hepatitis only emerged after world war two. Their identification has been associated with milestones which revolutionized medicine and public health. The discovery of HBV brought the first ever vaccine not prepared by tissue culture but initially directly from plasma and soon the first vaccine produced by genetic engineering. HBV vaccine proved to be the first "anti-cancer" vaccine by preventing hepatocellular carcinoma and practically eradicating it from childhood in Taiwan. Successful vaccines became also available for HAV and more recently HEV. The discovery of HCV in 1989 opened a new era since it was the first virus was identified by a direct molecular approach. Two billion people are infected with HBV and 350 million are chronic carriers of the virus. The extraordinary effectiveness of HBV vaccination was best illustrated in Taiwan and Singapore where in less than 2 decades HBs Ag carriers dropped from 9,1% to 2,7% and HCC from 27% to 17%. Successful development of nucleos(t)ides analogs make it now possible to fully control disease progression with a daily pill long term therapy. The progress in HCV therapy has been even more spectacular and successful treatment jumped from 6 % with interferon alone in 1986 to more than 80% in 2013 with triple combination therapies. Remarkably chronic hepatitis C is the only chronic disease which is curable. It will be soon possible to eradicate HCV infection with, an all oral, daily single pill (containing several molecules) for 3 to 6 months which will cure over 90% of patients. This unprecedented therapeutic victory benefiting hundred millions of people matches the triumphs over small pox, polio and tuberculosis. The next 10 years should undoubtedly witness cure or full control over all forms of acute and chronic

  1. New challenges for the graduate medical educator: implementing the milestones.

    PubMed

    Barr, Karen P; Massagli, Teresa L

    2014-07-01

    Physical medicine and rehabilitation residency programs will face new challenges as they implement the Milestones and establish a Clinical Competency Committee, new requirements in the Accreditation Council of Graduate Medical Education's Next Accreditation System. The milestones require programs to measure the capabilities of individual residents, and programs will be expected to show how residents progress to successively higher levels of behavior during the course of the residency. Program directors will be assisted by a committee of faculty whose role is to assess each individual resident's attainment of milestones and assist in the early identification of residents not making the expected progress. Programs will need to evaluate their assessment programs and will need to create a coherent mix of instruments to evaluate all of the milestones. Because the milestones are based on observable behaviors, a key component of this system will be direct observation by faculty of residents during patient care. However, many faculty are not trained in this skill. Faculty development in observational skills, workplace-based assessment skills, and providing formative feedback will be a very important aspect if the milestones are to be successfully used to help residents make developmental progress in their clinical competence. PMID:24658427

  2. Investing in International Information Exchange Activities to Improve the Safety, Cost Effectiveness and Schedule of Cleanup - 13281

    SciTech Connect

    Seed, Ian; James, Paula; Mathieson, John; Judd, Laurie; Elmetti-Ramirez, Rosa; Han, Ana

    2013-07-01

    With decreasing budgets and increasing pressure on completing cleanup missions as quickly, safely and cost-effectively as possible, there is significant benefit to be gained from collaboration and joint efforts between organizations facing similar issues. With this in mind, the US Department of Energy (DOE) and the UK Nuclear Decommissioning Authority (NDA) have formally agreed to share information on lessons learned on the development and application of new technologies and approaches to improve the safety, cost effectiveness and schedule of the cleanup legacy wastes. To facilitate information exchange a range of tools and methodologies were established. These included tacit knowledge exchange through facilitated meetings, conference calls and Site visits as well as explicit knowledge exchange through document sharing and newsletters. A DOE web-based portal has been established to capture these exchanges and add to them via discussion boards. The information exchange is operating at the Government-to-Government strategic level as well as at the Site Contractor level to address both technical and managerial topic areas. This effort has resulted in opening a dialogue and building working relationships. In some areas joint programs of work have been initiated thus saving resource and enabling the parties to leverage off one another activities. The potential benefits of high quality information exchange are significant, ranging from cost avoidance through identification of an approach to a problem that has been proven elsewhere to cost sharing and joint development of a new technology to address a common problem. The benefits in outcomes significantly outweigh the costs of the process. The applicability of the tools and methods along with the lessons learned regarding some key issues is of use to any organization that wants to improve value for money. In the waste management marketplace, there are a multitude of challenges being addressed by multiple organizations and

  3. Managing Complex Environmental Remediation amidst Aggressive Facility Revitalization Milestones

    SciTech Connect

    Richter Pack, S.

    2008-07-01

    Unlike the final closure projects at Rocky Flats and Fernald, many of the Department of Energy's future CERCLA and RCRA closure challenges will take place at active facilities, such as the Oak Ridge National Laboratory (ORNL) central campus. ORNL has aggressive growth plans for a Research Technology Park and cleanup must address and integrate D and D, soil and groundwater remediation, and on-going and future business plans for the Park. Different planning and tracking tools are needed to support closures at active facilities. To support some large Airport redevelopment efforts, we created tools that allowed the Airline lease-holder to perform environmental remediation on the same schedule as building D and D and new building construction, which in turn allowed them to migrate real estate from unusable to usable within an aggressive schedule. In summary: The FIM and OpenGate{sup TM} spatial analysis system were two primary tools developed to support simultaneous environmental remediation, D and D, and construction efforts at an operating facility. These tools helped redevelopers to deal with environmental remediation on the same schedule as building D and D and construction, thereby meeting their goals of opening gates, restarting their revenue streams, at the same time complying with all environmental regulations. (authors)

  4. Functional Communication Training and Chained Schedules of Reinforcement to Treat Challenging Behavior Maintained by Terminations of Activity Interruptions

    ERIC Educational Resources Information Center

    Falcomata, Terry S.; Roane, Henry S.; Muething, Colin S.; Stephenson, Kasey M.; Ing, Anna D.

    2012-01-01

    In this article, the authors evaluated functional communication training (FCT) and a chained schedule of reinforcement for the treatment of challenging behavior exhibited by two individuals diagnosed with Asperger syndrome and autism, respectively. Following a functional analysis with undifferentiated results, the authors demonstrated that…

  5. Guide to DCP Study Close-Out: Milestones and Tasks | Division of Cancer Prevention

    Cancer.gov

    This guide assists Consortium Lead Organization (CLO) planning for DCP study close-out. Study close-out tasks are organized under milestones, which help mark progress toward completion of the close-out process. Once tasks associated with a milestone are underway, planning for the next milestone may begin. Click on a milestone to view the associated close-out tasks. |

  6. Scheduling the Secondary School.

    ERIC Educational Resources Information Center

    Dempsey, Richard A.; Traverso, Henry P.

    This "how-to-do-it" manual on the intricacies of school scheduling offers both technical information and common sense advice about the process of secondary school scheduling. The first of six chapters provides an overview of scheduling; chapter 2 examines specific considerations for scheduling; chapter 3 surveys the scheduling models and their…

  7. Preparing medical students for obstetrics and gynecology milestone level one: a description of a pilot curriculum

    PubMed Central

    Morgan, Helen; Marzano, David; Lanham, Michael; Stein, Tamara; Curran, Diana; Hammoud, Maya

    2014-01-01

    Background The implementation of the Accreditation Council for Graduate Medical Education (ACGME) Milestones in the field of obstetrics and gynecology has arrived with Milestones Level One defined as the level expected of an incoming first-year resident. Purpose We designed, implemented, and evaluated a 4-week elective for fourth-year medical school students, which utilized a multimodal approach to teaching and assessing the Milestones Level One competencies. Methods The 78-hour curriculum utilized traditional didactic lectures, flipped classroom active learning sessions, a simulated paging curriculum, simulation training, embalmed cadaver anatomical dissections, and fresh-frozen cadaver operative procedures. We performed an assessment of student knowledge and surgical skills before and after completion of the course. Students also received feedback on their assessment and management of eight simulated paging scenarios. Students completed course content satisfaction surveys at the completion of each of the 4 weeks. Results Students demonstrated improvement in knowledge and surgical skills at the completion of the course. Paging confidence trended toward improvement at the completion of the course. Student satisfaction was high for all of the course content, and the active learning components of the curriculum (flipped classroom, simulation, and anatomy sessions) had higher scores than the traditional didactics in all six categories of our student satisfaction survey. Conclusions This pilot study demonstrates a practical approach for preparing fourth-year medical students for the expectations of Milestones Level One in obstetrics and gynecology. This curriculum can serve as a framework as medical schools and specific specialties work to meet the first steps of the ACGME's Next Accreditation System. PMID:25430640

  8. Detailed leak detection test plan and schedule for Oak Ridge National Laboratory liquid low-level waste active tanks

    SciTech Connect

    1995-01-01

    This document provides a plan and schedule for leak testing a portion of the Liquid Low-Level Waste (LLLW) system at the Oak Ridge National Laboratory (ORNL), Oak Ridge, Tennessee. It is a concise version of a more general leak testing plan that was prepared in response to the requirements of the Federal Facility Agreement (FFA) for the Oak Ridge Reservation (ORR). This plan includes a schedule for the initial reporting of the leak test results from the various tanks that will be tested. The FFA distinguishes four categories of tank and pipeline systems: new systems (Category A), doubly contained systems (Category B), singly contained systems (Category C), and inactive systems (Category D). The FFA specifically requires leak testing of the Category C systems; there are 14 such tanks addressed in this plan, plus one tank (W-12) that has been temporarily returned to service based on EPA and TDEC concurrence. A schedule for testing these tanks is also included. The plan and schedule also addresses an additional 15 Category B tanks have been demonstrated to meet secondary containment requirements. While these 15 tanks are addressed in this plan for the sake of completeness, they have been removed from the leak testing program based on the design demonstrations that show secondary containment. It is noted that the general plan included 42 tanks. Since that report was issued, 26 of those tanks have passed secondary containment design demonstrations and subsequently have been removed from this leak testing plan. In addition, one tank (LA-104) has been removed from service. Accordingly, this document addresses 15 of the LLLW tanks in the system; plans for testing the pipelines will be described in a separate document.

  9. Direct Observation Assessment of Milestones: Problems with Reliability

    PubMed Central

    Schott, Meghan; Kedia, Raashee; Promes, Susan B.; Swoboda, Thomas; O’Rourke, Kevin; Green, Walter; Liu, Rachel; Stansfield, Brent; Santen, Sally A.

    2015-01-01

    Introduction Emergency medicine (EM) milestones are used to assess residents’ progress. While some milestone validity evidence exists, there is a lack of standardized tools available to reliably assess residents. Inherent to this is a concern that we may not be truly measuring what we intend to assess. The purpose of this study was to design a direct observation milestone assessment instrument supported by validity and reliability evidence. In addition, such a tool would further lend validity evidence to the EM milestones by demonstrating their accurate measurement. Methods This was a multi-center, prospective, observational validity study conducted at eight institutions. The Critical Care Direct Observation Tool (CDOT) was created to assess EM residents during resuscitations. This tool was designed using a modified Delphi method focused on content, response process, and internal structure validity. Paying special attention to content validity, the CDOT was developed by an expert panel, maintaining the use of the EM milestone wording. We built response process and internal consistency by piloting and revising the instrument. Raters were faculty who routinely assess residents on the milestones. A brief training video on utilization of the instrument was completed by all. Raters used the CDOT to assess simulated videos of three residents at different stages of training in a critical care scenario. We measured reliability using Fleiss’ kappa and interclass correlations. Results Two versions of the CDOT were used: one used the milestone levels as global rating scales with anchors, and the second reflected a current trend of a checklist response system. Although the raters who used the CDOT routinely rate residents in their practice, they did not score the residents’ performances in the videos comparably, which led to poor reliability. The Fleiss’ kappa of each of the items measured on both versions of the CDOT was near zero. Conclusion The validity and

  10. Quarterly report on program cost and schedule, third quarter FY 1992

    SciTech Connect

    1992-10-01

    This report is intended to provide a summary of the cost and schedule performance for the civilian Radioactive Waste Management Program. Historical and current cost profiles (extracted from the DOE Financial information System) are presented for each of the major program elements. Also included in this report are the program schedule baseline, the status of near-term program milestones and the status of the Nuclear Waste Fund revenues and disbursements. This report includes data through June 1992.

  11. Optimizing tillage schedule for maintaining activity of the arbuscular mycorrhizal fungal population in a rainfed upland rice (Oryza sativa L.) agro-ecosystem.

    PubMed

    Maiti, D; Variar, M; Singh, R K

    2011-04-01

    Rainfed uplands in India are predominantly mono-cropped with rice (Oryza sativa L.) in the wet season (June/July to September/October) and grown under aerobic soil conditions. The remaining fallow period (winter followed by summer) of about 8-9 months leads to natural crash in the population of native arbuscular mycorrhizal fungi (AMF) in the soil. Attempts have been made to minimize this population crash by reducing soil disturbance-induced deleterious effects on native AMF activity of improperly scheduled off-season tillage, an agronomic recommendation for weed and disease (soil-borne) management, practiced by the upland farmers. On-farm (farmers' field) evaluation of effects of all suitable off-season tillage schedule combinations on rice during wet seasons of 2004, 2005, and 2006 revealed that a maximum of two off-season tillage schedules with a minimum gap of 13 weeks between them minimized the population crash of native AMF with a concomitant increase in phosphorus (P) uptake and grain yield of upland rice (variety "Vandana"). PMID:20544229

  12. Scheduling Reconsidered (Again!)

    ERIC Educational Resources Information Center

    Hentschke, Guilbert C.; Fowler, William J.

    1974-01-01

    Computer technicians bring to school scheduling a certain naivete regarding the operation of schools. School administrators play a fundamental role of informing technicians about education scheduling needs. (Author)

  13. Iterative refinement scheduling

    NASA Technical Reports Server (NTRS)

    Biefeld, Eric

    1992-01-01

    We present a heuristics-based approach to deep space mission scheduling which is modeled on the approach used by expert human schedulers in producing schedules for planetary encounters. New chronological evaluation techniques are used to focus the search by using information gained during the scheduling process to locate, classify, and resolve regions of conflict. Our approach is based on the assumption that during the construction of a schedule there exist several disjunct temporal regions where the demand for one resource type or a single temporal constraint dominates (bottleneck regions). If the scheduler can identify these regions and classify them based on their dominant constraint, then the scheduler can select the scheduling heuristic.

  14. Robust telescope scheduling

    NASA Technical Reports Server (NTRS)

    Swanson, Keith; Bresina, John; Drummond, Mark

    1994-01-01

    This paper presents a technique for building robust telescope schedules that tend not to break. The technique is called Just-In-Case (JIC) scheduling and it implements the common sense idea of being prepared for likely errors, just in case they should occur. The JIC algorithm analyzes a given schedule, determines where it is likely to break, reinvokes a scheduler to generate a contingent schedule for each highly probable break case, and produces a 'multiply contingent' schedule. The technique was developed for an automatic telescope scheduling problem, and the paper presents empirical results showing that Just-In-Case scheduling performs extremely well for this problem.

  15. Level-2 Milestone 2351: Terascale Simulation Facility Upgrade

    SciTech Connect

    Bailey, A M

    2007-10-02

    This report documents the LLNL TSF upgrade ASC L2 milestone 2351: Terascale Simulation Facility upgrade, due Sept. 30, 2007. The full text of the milestone is included in Attachment 1. The stated goal of the milestone was: 'Complete a 3-MW expansion of electrical power for computing systems in the east computer room of the Terascale Simulation Facility (TSF) and complete the final connection of all air handlers that were delivered as part of the TSF line item'. In this report we detail the upgrade and cover the results of the process to accept the system by testing, adjusting, balancing and finally start-up of the system in accordance with the detailed project commissioning plan to be developed by the system engineers during the design phase of the project. The quarterly reports for the upgrade and the text of the project commissioning plan are included at the end of this document as Attachments 2 and 3.

  16. Extracting the diffusion tensor from molecular dynamics simulation with Milestoning

    SciTech Connect

    Mugnai, Mauro L.; Elber, Ron

    2015-01-07

    We propose an algorithm to extract the diffusion tensor from Molecular Dynamics simulations with Milestoning. A Kramers-Moyal expansion of a discrete master equation, which is the Markovian limit of the Milestoning theory, determines the diffusion tensor. To test the algorithm, we analyze overdamped Langevin trajectories and recover a multidimensional Fokker-Planck equation. The recovery process determines the flux through a mesh and estimates local kinetic parameters. Rate coefficients are converted to the derivatives of the potential of mean force and to coordinate dependent diffusion tensor. We illustrate the computation on simple models and on an atomically detailed system—the diffusion along the backbone torsions of a solvated alanine dipeptide.

  17. Extracting the diffusion tensor from molecular dynamics simulation with Milestoning.

    PubMed

    Mugnai, Mauro L; Elber, Ron

    2015-01-01

    We propose an algorithm to extract the diffusion tensor from Molecular Dynamics simulations with Milestoning. A Kramers-Moyal expansion of a discrete master equation, which is the Markovian limit of the Milestoning theory, determines the diffusion tensor. To test the algorithm, we analyze overdamped Langevin trajectories and recover a multidimensional Fokker-Planck equation. The recovery process determines the flux through a mesh and estimates local kinetic parameters. Rate coefficients are converted to the derivatives of the potential of mean force and to coordinate dependent diffusion tensor. We illustrate the computation on simple models and on an atomically detailed system-the diffusion along the backbone torsions of a solvated alanine dipeptide.

  18. Effect of schedule on activity and toxicity of 5-azacytidine in acute leukemia: a Southwest Oncology Group Study.

    PubMed

    Saiki, J H; Bodey, G P; Hewlett, J S; Amare, M; Morrison, F S; Wilson, H E; Linman, J W

    1981-04-01

    One-hundred-fifty-four patients with acute leukemia and extensive prior chemotherapy were treated with 5-Azacytidine and evaluated according to five different schedules. One-hundred-twenty patients received adequate trials; 34 patients died within 14 days of onset of treatment. Nine patients achieved a complete remission (CR) and two achieved a partial remission. Although two of the treatments have a higher remission rate, the data were not statistically significant. The median time to CR was 48 days (range 21-173). The median duration of CR was 65 days (range 39-369). There was no difference in response rate according to cell type. The median age of responders was 31 years, and 39 years for nonresponders. Proportionately there were more women among responders (5M/6F) and more men (70M/39F) among nonresponders. At onset of therapy the median leukocyte counts were similar between responding (5.4 X 10(3)) and nonresponding (5.7 X 10(3)) patients, but the proportion of leukemic cells was significantly higher among nonresponding patients (46% vs. 7%). Toxicities included nausea, vomiting, diarrhea, skin rash, myalgias, prolonged myelosuppression, hypotension, and central nervous system stupor and/or coma. Lower dose continuous infusion schedules of five-, seven-, and ten-days duration appear effective and were associated with less toxicity. PMID:6164472

  19. Scheduling Spitzer: The SIRPASS Story

    NASA Technical Reports Server (NTRS)

    Mittman, David S.; Hawkins, Robert

    2013-01-01

    NASA's Spitzer Space Telescope was launched on August 25, 2003 from Florida's Cape Canaveral Air Force Base. Drifting in a unique Earth-trailing orbit around the Sun, Spitzer sees an optically invisible universe dominated by dust and stars. Since 1997, the Spitzer Integrated Resource Planning and Scheduling System (SIRPASS) has helped produce spacecraft activity plans for the Spitzer Space Telescope. SIRPASS is used by members of the Observatory Planning and Scheduling Team to plan, schedule and sequence the Telescope from data made available to them from the science and engineering community. Because of the volume of data that needs to be scheduled, SIRPASS offers a variety of automated assistants to aid in this task. This paper will describe the functional elements of the SIRPASS software system -- emphasizing the role that automation plays in the system -- and will highlight lessons learned for the software developer from a decade of Spitzer Space Telescope operations experience.

  20. The GBT Dynamic Scheduling System

    NASA Astrophysics Data System (ADS)

    McCarty, M. T.; Balser, D. S.; Braatz, J.; Clark, M. H.; Condon, J.; Creager, R. E.; Maddalena, R. J.; Marganian, P.; O'Neil, K.; Sessoms, E.; Shelton, A. L.

    2012-09-01

    The Robert C. Byrd Green Bank Telescope (GBT) Dynamic Scheduling System (DSS), in use since September, 2009, was designed to maximize observing efficiency while preserving telescope flexibility and data quality without creating undue adversity for the observers. Using observing criteria; observer availability and qualifications for remote observing; three-dimensional weather forecasts; and telescope state, the DSS software optimally schedules observers 24 to 48 hours in advance for a telescope that has a wide-range of capabilities and a geographical location with variable weather patterns. The DSS project was closed October 28, 2011 and will now enter a continuing maintenance and enhancement phase. Recent improvements include a new resource calendar for incorporating telescope maintenance activities, a sensitivity calculator that leverages the scheduling algorithms to facilitate consistent tools for proposal preparation, improved support for monitoring observations, scheduling of high frequency continuum and spectral line observations for both sparse and fully sampled array receivers, and additional session parameters for observations having special requirements.

  1. 14 CFR § 1274.908 - Milestone payments.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false Milestone payments. § 1274.908 Section § 1274.908 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION COOPERATIVE AGREEMENTS...) Taxpayer identification number (TIN). (x) While not required, the recipient is strongly encouraged...

  2. Apparatus as Milestones in the History of Comparative Psychology

    NASA Technical Reports Server (NTRS)

    Washburn, David A.; Rumbaugh, Duane M.; Putney, R. Thompson

    1994-01-01

    Significant apparatus developments from the history of comparative psychology are reviewed, including the contemporary trend toward computer use in research with nonhuman animals. It is argued that milestone apparatus served not only to open new lines of inquiry but also to shape or delimit the nature of the answers that were obtained.

  3. 10 CFR 603.570 - Determining milestone payment amounts.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Determining milestone payment amounts. 603.570 Section 603.570 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Pre-Award Business Evaluation Accounting, Payments, and Recovery of Funds § 603.570...

  4. Social Development and Feeding Milestones of Young Down Syndrome Children.

    ERIC Educational Resources Information Center

    And Others; Cullen, Susan M.

    1981-01-01

    The data revealed that young Down syndrome children attained significantly higher scores on the Vineland Social Maturity Scale and achieved most feeding milestones much earlier if they had no or only mild congenital heart disease, if their parents followed through appropriately with furnished guidance, and if they had "good" muscle tone. (Author)

  5. EOS distributed planning and scheduling prototype

    NASA Technical Reports Server (NTRS)

    Hull, Larry G.; Peters, Stephen F.; Davis, Randy

    1993-01-01

    Some of the more significant lessons learned during the development of the Earth Observing System (EOS) Distributed Planning and Scheduling Prototype are presented. The need for a central scheduler is not demonstrated. A mapping of scheduling and conflict-resolution responsibility across the nodes of the EOS distributed scheduling system is developed and shown to be both feasible and appropriate. Complex instrument scheduling is mostly accomplished at the ICC/IST (instrument control center/instrumental support terminal) with 'slidable' flexibility for slews and some kinds of calibrations resolved at the EOS Operations Center (EOC). All nodes have full visibility interinstrument contention for resource and environmental rights, e.g., vibration, thermal, and electromagnetic. The EOC assigns, by activity, initial action responsibility for conflict resolution to a node which is party to the conflict. Most interinstrument conflicts are resolved by the ICCs and ISTs during an intermediate scheduling phase while the EOC is negotiating a TDRS schedule with the NCC.

  6. Aspects of job scheduling

    NASA Technical Reports Server (NTRS)

    Phillips, K.

    1976-01-01

    A mathematical model for job scheduling in a specified context is presented. The model uses both linear programming and combinatorial methods. While designed with a view toward optimization of scheduling of facility and plant operations at the Deep Space Communications Complex, the context is sufficiently general to be widely applicable. The general scheduling problem including options for scheduling objectives is discussed and fundamental parameters identified. Mathematical algorithms for partitioning problems germane to scheduling are presented.

  7. Toddlers’ Fine Motor Milestone Achievement Is Associated with Early Touchscreen Scrolling

    PubMed Central

    Bedford, Rachael; Saez de Urabain, Irati R.; Cheung, Celeste H. M.; Karmiloff-Smith, Annette; Smith, Tim J.

    2016-01-01

    Touchscreen technologies provide an intuitive and attractive source of sensory/cognitive stimulation for young children. Despite fears that usage may have a negative impact on toddlers’ cognitive development, empirical evidence is lacking. The current study presents results from the UK Toddler Attentional Behaviours and LEarning with Touchscreens (TABLET) project, examining the association between toddlers’ touchscreen use and the attainment of developmental milestones. Data were gathered in an online survey of 715 parents of 6- to 36-month-olds to address two research questions: (1) How does touchscreen use change from 6 to 36 months? (2) In toddlers (19–36 months, i.e., above the median age, n = 366), how does retrospectively reported age of first touchscreen usage relate to gross motor (i.e., walking), fine motor (i.e., stacking blocks), and language (i.e., producing two-word utterances) milestones? In our sample, the proportion of children using touchscreens, as well as the average daily usage time, increased with age (youngest quartile, 6–11 months: 51.22% users, 8.53 min per day; oldest quartile, 26–36 months: 92.05% users, average use of 43.95 min per day). In toddlers, aged 19–36 months, age of first touchscreen use was significantly associated with fine motor (stacking blocks), p = 0.03, after controlling for covariates age, sex, mother’s education (a proxy for socioeconomic status) as well as age of early fine motor milestone achievement (pincer grip). This effect was only present for active scrolling of the touchscreen p = 0.04, not for video watching. No significant relationships were found between touchscreen use and either gross motor or language milestones. Touchscreen use increases rapidly over the first 3 years of life. In the current study, we find no evidence to support a negative association between the age of first touchscreen usage and developmental milestones. Indeed, earlier touchscreen use, specifically scrolling of the screen

  8. Toddlers' Fine Motor Milestone Achievement Is Associated with Early Touchscreen Scrolling.

    PubMed

    Bedford, Rachael; Saez de Urabain, Irati R; Cheung, Celeste H M; Karmiloff-Smith, Annette; Smith, Tim J

    2016-01-01

    Touchscreen technologies provide an intuitive and attractive source of sensory/cognitive stimulation for young children. Despite fears that usage may have a negative impact on toddlers' cognitive development, empirical evidence is lacking. The current study presents results from the UK Toddler Attentional Behaviours and LEarning with Touchscreens (TABLET) project, examining the association between toddlers' touchscreen use and the attainment of developmental milestones. Data were gathered in an online survey of 715 parents of 6- to 36-month-olds to address two research questions: (1) How does touchscreen use change from 6 to 36 months? (2) In toddlers (19-36 months, i.e., above the median age, n = 366), how does retrospectively reported age of first touchscreen usage relate to gross motor (i.e., walking), fine motor (i.e., stacking blocks), and language (i.e., producing two-word utterances) milestones? In our sample, the proportion of children using touchscreens, as well as the average daily usage time, increased with age (youngest quartile, 6-11 months: 51.22% users, 8.53 min per day; oldest quartile, 26-36 months: 92.05% users, average use of 43.95 min per day). In toddlers, aged 19-36 months, age of first touchscreen use was significantly associated with fine motor (stacking blocks), p = 0.03, after controlling for covariates age, sex, mother's education (a proxy for socioeconomic status) as well as age of early fine motor milestone achievement (pincer grip). This effect was only present for active scrolling of the touchscreen p = 0.04, not for video watching. No significant relationships were found between touchscreen use and either gross motor or language milestones. Touchscreen use increases rapidly over the first 3 years of life. In the current study, we find no evidence to support a negative association between the age of first touchscreen usage and developmental milestones. Indeed, earlier touchscreen use, specifically scrolling of the screen, was

  9. Toddlers' Fine Motor Milestone Achievement Is Associated with Early Touchscreen Scrolling.

    PubMed

    Bedford, Rachael; Saez de Urabain, Irati R; Cheung, Celeste H M; Karmiloff-Smith, Annette; Smith, Tim J

    2016-01-01

    Touchscreen technologies provide an intuitive and attractive source of sensory/cognitive stimulation for young children. Despite fears that usage may have a negative impact on toddlers' cognitive development, empirical evidence is lacking. The current study presents results from the UK Toddler Attentional Behaviours and LEarning with Touchscreens (TABLET) project, examining the association between toddlers' touchscreen use and the attainment of developmental milestones. Data were gathered in an online survey of 715 parents of 6- to 36-month-olds to address two research questions: (1) How does touchscreen use change from 6 to 36 months? (2) In toddlers (19-36 months, i.e., above the median age, n = 366), how does retrospectively reported age of first touchscreen usage relate to gross motor (i.e., walking), fine motor (i.e., stacking blocks), and language (i.e., producing two-word utterances) milestones? In our sample, the proportion of children using touchscreens, as well as the average daily usage time, increased with age (youngest quartile, 6-11 months: 51.22% users, 8.53 min per day; oldest quartile, 26-36 months: 92.05% users, average use of 43.95 min per day). In toddlers, aged 19-36 months, age of first touchscreen use was significantly associated with fine motor (stacking blocks), p = 0.03, after controlling for covariates age, sex, mother's education (a proxy for socioeconomic status) as well as age of early fine motor milestone achievement (pincer grip). This effect was only present for active scrolling of the touchscreen p = 0.04, not for video watching. No significant relationships were found between touchscreen use and either gross motor or language milestones. Touchscreen use increases rapidly over the first 3 years of life. In the current study, we find no evidence to support a negative association between the age of first touchscreen usage and developmental milestones. Indeed, earlier touchscreen use, specifically scrolling of the screen, was

  10. $sup 238$Pu fuel form activities

    SciTech Connect

    Not Available

    1987-06-01

    This report for STYPu Fuel Form Activities has one main section: SRP-PuFF Facility. The SRL portion of this program has been completed. The program status, budget information, and milestone schedules are discussed. The SRP portion of this report summarizes production of STYPuO2 fuel forms for use in radioisotopic thermoelectric generators (RTG's) in the Plutonium Fuel Form (Puff) Facility at the Savannah River Plant. The PuFF Facility has been placed in a production readiness mode of operation pending funding of additional heat source programs.

  11. Effect of restricted feeding schedule on seasonal shifting of daily demand-feeding pattern and food anticipatory activity in European sea bass (Dicentrarchus labrax L.).

    PubMed

    Azzaydi, M; Rubio, V C; López, F J Martínez; Sánchez-Vázquez, F J; Zamora, S; Madrid, J A

    2007-01-01

    The effect of restricted feeding schedule was investigated on the seasonal shifting of daily demand-feeding pattern and food anticipatory activity in European sea bass (Dicentrarchus labrax) held under natural environmental conditions in an outdoor laboratory. To that end, demand-feeding behavior was continuously monitored for approximately one year in four groups of 15 fish each exposed to natural fluctuations of water temperature (from 13.2 degrees C to 27.4 degrees C) and photophase (from 9.5 h to 14.5 h of light). When the animals were subjected to a time-restricted feeding schedule, the demand-feeding rhythm rapidly synchronized to the three periods of food availability: the first meal (FM) from 08:00 to 09:00 h, the second meal (SM) from 16:00 to 17:00 h, and the third meal (TM) from 00:00 to 01:00 h. The occurrence of demand-feeding activity into the three periods of food availability displayed a double seasonal shift: fish that self-fed mostly during the daytime periods of feeding availability (FM and SM) in summer and autumn changed to nocturnal feeding (TM) from December to April, returning to diurnal preferences in April. Food-demands appeared to be predominantly associated with feed availability, reaching its maximum levels during the hours of reward. In addition, feeding anticipatory activity (FAA) was observed. A relationship was detected between the duration of FAA and feeding-time, with shortest FAA (30-60 min) when mealtime occurred just after sunrise (FM) or sunset (TM). These findings demonstrate the ability of sea bass to self-feed under time-restricted schedules, and show a seasonal-phase inversion in demand-feeding activity in spite of the restrictions in their feeding availability. Sea bass can use external signals as reference to anticipate the time of feed availability. This information may be useful for designing new feeding strategies for European sea bass fish farming.

  12. Analysis of alternatives for immobilized low activity waste disposal

    SciTech Connect

    Burbank, D.A.

    1997-10-28

    This report presents a study of alternative disposal system architectures and implementation strategies to provide onsite near-surface disposal capacity to receive the immobilized low-activity waste produced by the private vendors. The analysis shows that a flexible unit strategy that provides a suite of design solutions tailored to the characteristics of the immobilized low-activity waste will provide a disposal system that best meets the program goals of reducing the environmental, health, and safety impacts; meeting the schedule milestones; and minimizing the life-cycle cost of the program.

  13. Dedicated heterogeneous node scheduling including backfill scheduling

    DOEpatents

    Wood, Robert R.; Eckert, Philip D.; Hommes, Gregg

    2006-07-25

    A method and system for job backfill scheduling dedicated heterogeneous nodes in a multi-node computing environment. Heterogeneous nodes are grouped into homogeneous node sub-pools. For each sub-pool, a free node schedule (FNS) is created so that the number of to chart the free nodes over time. For each prioritized job, using the FNS of sub-pools having nodes useable by a particular job, to determine the earliest time range (ETR) capable of running the job. Once determined for a particular job, scheduling the job to run in that ETR. If the ETR determined for a lower priority job (LPJ) has a start time earlier than a higher priority job (HPJ), then the LPJ is scheduled in that ETR if it would not disturb the anticipated start times of any HPJ previously scheduled for a future time. Thus, efficient utilization and throughput of such computing environments may be increased by utilizing resources otherwise remaining idle.

  14. Assessment of developmental milestones in rodents.

    PubMed

    Heyser, Charles J

    2004-02-01

    Developmental tests are used to characterize early markers of behavior for investigation of the neurobiology of these behaviors, and to assess the impact of early prenatal or postnatal insult. These perturbations may include pharmacological, environmental, and genetic manipulations. At birth the rat is capable of some specific activities, but its movements are uncoordinated and seemingly random, its tactile sensitivity is not fully developed, and its ear canals and eyes remain closed until several days after birth. Postnatal development consists mainly of the continuation of processes begun earlier. This unit presents protocols for the most commonly used animal tests of developmental reflexology, including negative geotaxis, cliff avoidance, placing responses, tactile and acoustic startle responses, surface and air righting reflexes, crossed extensor reflex, rooting reflex, grasp reflex, bar holding, and horizontal and vertical screen tests.

  15. Immunization Schedules for Adults

    MedlinePlus

    ... ACIP Vaccination Recommendations Why Immunize? Vaccines: The Basics Immunization Schedules for Adults in Easy-to-read Formats ... previous immunizations. View or Print a Schedule Recommended Immunizations for Adults (19 Years and Older) by Age ...

  16. Childhood Immunization Schedule

    MedlinePlus

    ... Recommendations Why Immunize? Vaccines: The Basics Instant Childhood Immunization Schedule Recommend on Facebook Tweet Share Compartir Get ... date. See Disclaimer for additional details. Based on Immunization Schedule for Children 0 through 6 Years of ...

  17. Organized Activity Participation, Positive Youth Development, and the Over-Scheduling Hypothesis. Social Policy Report. Volume 20, Number 4

    ERIC Educational Resources Information Center

    Mahoney, Joseph L.; Harris, Angel L.; Eccles, Jacquelynne S.

    2006-01-01

    There is increasing awareness that how young people spend their time outside of school has consequences for their development. As part of this awareness, interest in organized activities--extracurricular activities, after-school programs, and youth organizations--has grown markedly. On balance, the bulk of research on organized activities has…

  18. Some Important Milestones in the Field of Blood Clotting.

    PubMed

    Doolittle, Russell F

    2016-01-01

    Several different kinds of 'milestone' in the field of blood coagulation are described from the middle decades of the 20th century. Although viewed from the standpoint of clotting per se, attention is also given to implications for innate immunity. The first milestone considered is the protracted saga of clotting dependence on vitamin K, an adventure that spanned more than five decades beginning in the 1920s. The second has to do with the discovery of a half-dozen 'new' clotting factors during the period immediately following World War II. A third pursues a narrower focus and examines the once mysterious transformation of fibrinogen into fibrin. Finally, the clinical treatment of classical hemophilia had a remarkable turning point in the 1960s as the result of simple but sensible measures. PMID:26667674

  19. Reinforcement learning in scheduling

    NASA Technical Reports Server (NTRS)

    Dietterich, Tom G.; Ok, Dokyeong; Zhang, Wei; Tadepalli, Prasad

    1994-01-01

    The goal of this research is to apply reinforcement learning methods to real-world problems like scheduling. In this preliminary paper, we show that learning to solve scheduling problems such as the Space Shuttle Payload Processing and the Automatic Guided Vehicle (AGV) scheduling can be usefully studied in the reinforcement learning framework. We discuss some of the special challenges posed by the scheduling domain to these methods and propose some possible solutions we plan to implement.

  20. Milestone Report - M31SW030904 - Sigma Team Coordination Meeting

    SciTech Connect

    Jubin, Robert Thomas

    2010-11-24

    This documents the completion of the FCR&D Level 3 milestone for the Off-Gas Sigma Team - ORNL work package (FTOR11SW0309), “Sigma Team Coordination Meeting” (M31SW030904), due 30 November 10. The subject meeting was held at Idaho National Laboratory on October 12 and 13, 2010. The agenda and meeting minutes are attached to this memo.

  1. Automated Scheduling of Personnel to Staff Operations for the Mars Science Laboratory

    NASA Technical Reports Server (NTRS)

    Knight, Russell; Mishkin, Andrew; Allbaugh, Alicia

    2014-01-01

    Leveraging previous work on scheduling personnel for space mission operations, we have adapted ASPEN (Activity Scheduling and Planning Environment) [1] to the domain of scheduling personnel for operations of the Mars Science Laboratory. Automated scheduling of personnel is not new. We compare our representations to a sampling of employee scheduling systems available with respect to desired features. We described the constraints required by MSL personnel schedulers and how each is handled by the scheduling algorithm.

  2. Historical milestones of a long pathway.

    PubMed

    Roy, Thomas

    2011-01-01

    Hemodiafiltration (HDF), developed from the combination of hemodialysis and hemofiltration, is considered to be the most effective current procedure to remove uremic toxins from the blood of kidney patients. Historically, the clinical use of HDF was for many years limited due to the cost burden related to the large amount of sterile volume replacement fluid needed. The solution offered was on-line preparation of replacement fluid from standard dialysate by means of membrane filtration. Industry opened to this concept quite early and worked on various technical solutions between the early 1980s and the late 1990s before real state-of-the-art systems became commercially available on a broad basis. This article reviews in particular the activities of initially Fresenius and later Fresenius Medical Care in this field and identifies major concepts and prototypes up to today's commercially available high-end product--the 5008 therapy system--where on-line HDF finally became integrated as a standard component. PMID:22188683

  3. Nocistatin: milestone of one decade of research.

    PubMed

    Okuda-Ashitaka, Emiko; Ito, Seiji

    2015-01-01

    A neuropeptide nociceptin or orphanin FQ (N/OFQ) is an endogenous ligand for the orphan opioid receptor-like receptor. During studies on the analysis of the precursor of N/OFQ, we identified a novel neuropeptide produced from the same precursor and named it "nocistatin (NST)". Intrathecal (i.t.) administration of N/OFQ induces pain responses including touch-evoked allodynia and thermal hyperalgesia, and simultaneous administration of NST blocks the allodynia and hyperalgesia induced by N/OFQ. In the years since these discoveries, N/OFQ has been shown to be involved in a wide range of pharmacological activities, such as relaying pain perception in peripheral tissues, to the central nervous system, and NST was shown to have opposite effects on various central functions evoked by N/OFQ. Pharmacological characterization using various neurotransmitter agents, agonists, antagonists and knockout mice in vivo; electrophysiological and immunohistological analysis ex vivo; and molecular cloning using affinity chromatography of high-performance affinity nanobeads; and protein processing measurement using bioluminescence resonance energy transfer (BRET) in vitro have generated new insights into pain transmission regulated by NST and N/OFQ. This review focuses on the molecular and cellular mechanisms of pain transmission regulated by NST. PMID:25345611

  4. Block Scheduling. Research Brief

    ERIC Educational Resources Information Center

    Muir, Mike

    2003-01-01

    What are the effects of block scheduling? Results of transitioning from traditional to block scheduling are mixed. Some studies indicate no change in achievement results, nor change in teachers' opinions about instructional strategies. Other studies show that block scheduling doesn't work well for Advanced Placement or Music courses, that "hard to…

  5. Two Relations to Estimate Membrane Permeability Using Milestoning.

    PubMed

    Votapka, Lane W; Lee, Christopher T; Amaro, Rommie E

    2016-08-25

    Prediction of passive permeation rates of solutes across lipid bilayers is important to drug design, toxicology, and other biological processes such as signaling. The inhomogeneous solubility-diffusion (ISD) equation is traditionally used to relate the position-dependent potential of mean force and diffusivity to the permeability coefficient. The ISD equation is derived via the Smoluchowski equation and assumes overdamped system dynamics. It has been suggested that the complex membrane environment may exhibit more complicated damping conditions. Here we derive a variant of the inhomogeneous solubility diffusion equation as a function of the mean first passage time (MFPT) and show how milestoning, a method that can estimate kinetic quantities of interest, can be used to estimate the MFPT of membrane crossing and, by extension, the permeability coefficient. We further describe a second scheme, agnostic to the damping condition, to estimate the permeability coefficient from milestoning results or other methods that compute a probability of membrane crossing. The derived relationships are tested using a one-dimensional Langevin dynamics toy system confirming that the presented theoretical methods can be used to estimate permeabilities given simulation and milestoning results. PMID:27154639

  6. Historical milestones and discoveries that shaped the toxicology sciences.

    PubMed

    Hayes, Antoinette N; Gilbert, Steven G

    2009-01-01

    Knowledge of the toxic and healing properties of plants, animals, and minerals has shaped civilization for millennia. The foundations of modern toxicology are built upon the significant milestones and discoveries of serendipity and crude experimentation. Throughout the ages, toxicological science has provided information that has shaped and guided society. This chapter examines the development of the discipline of toxicology and its influence on civilization by highlighting significant milestones and discoveries related to toxicology. The examples shed light on the beginnings of toxicology, as well as examine lessons learned and re-learned. This chapter also examines how toxicology and the toxicologist have interacted with other scientific and cultural disciplines, including religion, politics, and the government. Toxicology has evolved to a true scientific discipline with its own dedicated scientists, educational institutes, sub-disciplines, professional societies, and journals. It now stands as its own entity while traversing such fields as chemistry, physiology, pharmacology, and molecular biology. We invite you to join us on a path of discovery and to offer our suggestions as to what are the most significant milestones and discoveries in toxicology. Additional information is available on the history section of Toxipedia (www.toxipedia.org).

  7. Two Relations to Estimate Membrane Permeability Using Milestoning

    PubMed Central

    2016-01-01

    Prediction of passive permeation rates of solutes across lipid bilayers is important to drug design, toxicology, and other biological processes such as signaling. The inhomogeneous solubility-diffusion (ISD) equation is traditionally used to relate the position-dependent potential of mean force and diffusivity to the permeability coefficient. The ISD equation is derived via the Smoluchowski equation and assumes overdamped system dynamics. It has been suggested that the complex membrane environment may exhibit more complicated damping conditions. Here we derive a variant of the inhomogeneous solubility diffusion equation as a function of the mean first passage time (MFPT) and show how milestoning, a method that can estimate kinetic quantities of interest, can be used to estimate the MFPT of membrane crossing and, by extension, the permeability coefficient. We further describe a second scheme, agnostic to the damping condition, to estimate the permeability coefficient from milestoning results or other methods that compute a probability of membrane crossing. The derived relationships are tested using a one-dimensional Langevin dynamics toy system confirming that the presented theoretical methods can be used to estimate permeabilities given simulation and milestoning results. PMID:27154639

  8. [Milestones of cardivascular pharmacotherapy: salicylates and aspirin].

    PubMed

    Jerie, P

    2006-01-01

    The analgesic and antipyretic effect of the bark of willow has been known in Egypt and Greece for canturies. The modem era of salicylates starts with a letter sent 1758 by Reverend Edward Stone to The Royal Society in London. He described "an account of the success of the bark of willow in the cure of agues". His report. erroneously attributed to Edmond Stone. was published five years later. The active ingredient of willow bark. "salicine". was first isolated 1828 by Joseph Buchner, then by Henri Leroux, and also prepared from the oil of wintergreen (Gaultheria) and meadowsweet (Spirea ulmaria) by J. W. Lowig 1833. and called "Spirsäure", which was already pure acetylsalicylic acid. It was also synthetised 1853 by Ch. Gerhardt and finally 1897 in Bayer's laboratoires by Felix Hoffman, who also demonstrated its antiinflammatory efficacy. After two years of clinical trials with low doses, Bayer's management decided to start the productions and launched Aspirin as an analgetic worldwide in summer 1899. The first ASPIRIN ERA bagun. A completely new epoch started when J. N. Vane and Priscilla Piner demonstrated 1971 that the main mechanism of action of aspirin-like drugs is the inhibition of prostaglandin synthesis. In later studies the potency to inhibit platelet aggregation with small doses of aspirin (30-125 mg) was demonstrated. The Physicians'Health Study 1988 confirmed this effect: aspirin significantly reduced the risk of both, fatal and non-fatal myocardial infarction. and is now used in primary and secondary prevention of atherosclerosis. However the idea was not new: The use of salicylates and aspirin was throughly discussed more than 50 years ago: Paul C. Gibson published 1949 a well-documented case report on efficacy of aspirin in patients with angina, and Kl. Weber and P. Klein in Prague used Gibson's mixture successfully for patients with acute myocardial infarction (1951). Recently, the efficacy and security, the interactions and side-effects of low

  9. The Role of Physical Activity and Feeding Schedule on the Kinetics of Inhaled and Oral Toluene in Rats

    EPA Science Inventory

    This manuscript provides new information regarding factors that affect the toxicokinetics of toluene, a hazardous air pollutant with acute neurotoxic activity. Toluene is a prototype compound of the class of volatile organic compounds (VOCs), which have similar CNS activity and k...

  10. The sleeping giant: Reinforcement schedules.

    PubMed

    Zeiler, M D

    1984-11-01

    Schedule research has been the core of operant conditioning, but it is no longer an active area, at least with respect to its traditional focus of describing and explaining moment-to-moment behavior. Yet schedules are central in psychology: Not only do they establish lawful behavior, but they also play a major role in determining the effects of other variables. The reason for the decline appears to be primarily theoretical, in that the work seems not to have led to meaningful integration. The search for controlling variables brought into play by schedule specification has proven unsuccessful, and a catalog of all possible schedule effects is of limited interest. The paper reviews the reasons for the contemporary state of affairs. One prediction about future developments is that instead of revealing component variables and their modes of interaction, schedule effects will be treated as basic empirical laws. Theory will take the form of abstract statements that integrate these separate laws by reference to higher-order principles rather than by reduction to supposedly simpler component variables.

  11. The sleeping giant: Reinforcement schedules

    PubMed Central

    Zeiler, Michael D.

    1984-01-01

    Schedule research has been the core of operant conditioning, but it is no longer an active area, at least with respect to its traditional focus of describing and explaining moment-to-moment behavior. Yet schedules are central in psychology: Not only do they establish lawful behavior, but they also play a major role in determining the effects of other variables. The reason for the decline appears to be primarily theoretical, in that the work seems not to have led to meaningful integration. The search for controlling variables brought into play by schedule specification has proven unsuccessful, and a catalog of all possible schedule effects is of limited interest. The paper reviews the reasons for the contemporary state of affairs. One prediction about future developments is that instead of revealing component variables and their modes of interaction, schedule effects will be treated as basic empirical laws. Theory will take the form of abstract statements that integrate these separate laws by reference to higher-order principles rather than by reduction to supposedly simpler component variables. PMID:16812403

  12. Certification of Completion of Level-2 Milestone 461: Deploy First Phase of I/O Infrastructure for Purple

    SciTech Connect

    Gary, M; Wiltzius, D

    2005-11-17

    This report describes the deployment and demonstration of the first phase of the I/O infrastructure for Purple. The report and the references herein are intended to certify the completion of the following Level 2 Milestone from the ASC FY04-05 Implementation Plan, due at the end of Quarter 4 in FY05. The milestone is defined as follows: ''External networking infrastructure installation and performance analysis will be completed for the initial delivery of Purple. The external networking infrastructure includes incorporation of a new 10 Gigabit Ethernet fabric linking the platform to the LLNL High Performance Storage System (HPSS) and other center equipment. The LLNL archive will be upgraded to HPSS Release 5.1 to support the requirements of the machine and performance analysis will be completed using the newly deployed I/O infrastructure. Demonstrated throughput to the archive for this infrastructure will be a minimum of 1.5GB/s with a target of 3GB/s. Since Purple delivery is not scheduled until late Q3, demonstration of these performance goals will use parts of Purple and/or an aggregate of other existing resources.''

  13. Teaching Children with Autism to Play a Video Game Using Activity Schedules and Game-Embedded Simultaneous Video Modeling

    ERIC Educational Resources Information Center

    Blum-Dimaya, Alyssa; Reeve, Sharon A.; Reeve, Kenneth F.; Hoch, Hannah

    2010-01-01

    Children with autism have severe and pervasive impairments in social interactions and communication that impact most areas of daily living and often limit independent engagement in leisure activities. We taught four children with autism to engage in an age-appropriate leisure skill, playing the video game Guitar Hero II[TM], through the use of (a)…

  14. 324 Building special-case waste assessment in support of the 324 Building closure (TPA milestone M-89-05)

    SciTech Connect

    Hobart, R.L.

    1998-05-12

    Hanford Federal Facility Agreement and Consent Order, also known as the Tri-Party Agreement Milestone M-89-05 requires US Department of Energy, Richland Operations Office to complete a 324 Building Special Case Waste Assessment in Support of the 324 Building Closure. This document has been prepared with the intent of meeting this regulatory commitment. Alternatives for the Special Case Wastes located in the 324 Building were defined and analyzed. Based on the criteria of safety, environmental, complexity of interfaces, risk, cost, schedule, and long-term operability and maintainability, the best alternative was chosen. Waste packaging and transportation options are also included in the recommendations. The waste disposition recommendations for the B-Cell dispersibles/tank heels and High-Level Vault packaged residuals are to direct them to the Plutonium Uranium Extraction Facility (PUREX) Number 2 storage tunnel.

  15. Integrated resource scheduling in a distributed scheduling environment

    NASA Technical Reports Server (NTRS)

    Zoch, David; Hall, Gardiner

    1988-01-01

    The Space Station era presents a highly-complex multi-mission planning and scheduling environment exercised over a highly distributed system. In order to automate the scheduling process, customers require a mechanism for communicating their scheduling requirements to NASA. A request language that a remotely-located customer can use to specify his scheduling requirements to a NASA scheduler, thus automating the customer-scheduler interface, is described. This notation, Flexible Envelope-Request Notation (FERN), allows the user to completely specify his scheduling requirements such as resource usage, temporal constraints, and scheduling preferences and options. The FERN also contains mechanisms for representing schedule and resource availability information, which are used in the inter-scheduler inconsistency resolution process. Additionally, a scheduler is described that can accept these requests, process them, generate schedules, and return schedule and resource availability information to the requester. The Request-Oriented Scheduling Engine (ROSE) was designed to function either as an independent scheduler or as a scheduling element in a network of schedulers. When used in a network of schedulers, each ROSE communicates schedule and resource usage information to other schedulers via the FERN notation, enabling inconsistencies to be resolved between schedulers. Individual ROSE schedules are created by viewing the problem as a constraint satisfaction problem with a heuristically guided search strategy.

  16. Analyzing milestoning networks for molecular kinetics: Definitions, algorithms, and examples

    NASA Astrophysics Data System (ADS)

    Viswanath, Shruthi; Kreuzer, Steven M.; Cardenas, Alfredo E.; Elber, Ron

    2013-11-01

    Network representations are becoming increasingly popular for analyzing kinetic data from techniques like Milestoning, Markov State Models, and Transition Path Theory. Mapping continuous phase space trajectories into a relatively small number of discrete states helps in visualization of the data and in dissecting complex dynamics to concrete mechanisms. However, not only are molecular networks derived from molecular dynamics simulations growing in number, they are also getting increasingly complex, owing partly to the growth in computer power that allows us to generate longer and better converged trajectories. The increased complexity of the networks makes simple interpretation and qualitative insight of the molecular systems more difficult to achieve. In this paper, we focus on various network representations of kinetic data and algorithms to identify important edges and pathways in these networks. The kinetic data can be local and partial (such as the value of rate coefficients between states) or an exact solution to kinetic equations for the entire system (such as the stationary flux between vertices). In particular, we focus on the Milestoning method that provides fluxes as the main output. We proposed Global Maximum Weight Pathways as a useful tool for analyzing molecular mechanism in Milestoning networks. A closely related definition was made in the context of Transition Path Theory. We consider three algorithms to find Global Maximum Weight Pathways: Recursive Dijkstra's, Edge-Elimination, and Edge-List Bisection. The asymptotic efficiency of the algorithms is analyzed and numerical tests on finite networks show that Edge-List Bisection and Recursive Dijkstra's algorithms are most efficient for sparse and dense networks, respectively. Pathways are illustrated for two examples: helix unfolding and membrane permeation. Finally, we illustrate that networks based on local kinetic information can lead to incorrect interpretation of molecular mechanisms.

  17. Automated telescope scheduling

    NASA Technical Reports Server (NTRS)

    Johnston, Mark D.

    1988-01-01

    With the ever increasing level of automation of astronomical telescopes the benefits and feasibility of automated planning and scheduling are becoming more apparent. Improved efficiency and increased overall telescope utilization are the most obvious goals. Automated scheduling at some level has been done for several satellite observatories, but the requirements on these systems were much less stringent than on modern ground or satellite observatories. The scheduling problem is particularly acute for Hubble Space Telescope: virtually all observations must be planned in excruciating detail weeks to months in advance. Space Telescope Science Institute has recently made significant progress on the scheduling problem by exploiting state-of-the-art artificial intelligence software technology. What is especially interesting is that this effort has already yielded software that is well suited to scheduling groundbased telescopes, including the problem of optimizing the coordinated scheduling of more than one telescope.

  18. Hydrogen milestone could help lower fossil fuel refining costs

    ScienceCinema

    McGraw, Jennifer

    2016-07-12

    Hydrogen researchers at the U.S. Department of Energy's Idaho National Laboratory have reached another milestone on the road to reducing carbon emissions and protecting the nation against the effects of peaking world oil production. Stephen Herring, laboratory fellow and technical director of the INL High Temperature Electrolysis team, today announced that the latest fuel cell modification has set a new mark in endurance. The group's Integrated Laboratory Scale experiment has now operated continuously for 2,583 hours at higher efficiencies than previously attained. Learn more about INL research at http://www.facebook.com/idahonationallaboratory.

  19. Hydrogen milestone could help lower fossil fuel refining costs

    SciTech Connect

    McGraw, Jennifer

    2009-01-01

    Hydrogen researchers at the U.S. Department of Energy's Idaho National Laboratory have reached another milestone on the road to reducing carbon emissions and protecting the nation against the effects of peaking world oil production. Stephen Herring, laboratory fellow and technical director of the INL High Temperature Electrolysis team, today announced that the latest fuel cell modification has set a new mark in endurance. The group's Integrated Laboratory Scale experiment has now operated continuously for 2,583 hours at higher efficiencies than previously attained. Learn more about INL research at http://www.facebook.com/idahonationallaboratory.

  20. Influence of schedule of interleukin 2 administration on therapy with interleukin 2 and lymphokine activated killer cells.

    PubMed

    Thompson, J A; Lee, D J; Lindgren, C G; Benz, L A; Collins, C; Shuman, W P; Levitt, D; Fefer, A

    1989-01-01

    The purpose of this study was to compare the toxicity, immunomodulatory changes, and antitumor efficacy of interleukin 2 (IL-2) and lymphokine activated killer (LAK) cell therapy with two durations of IL-2 infusion. Patients with progressive melanoma, non-Hodgkin's lymphoma, renal carcinoma, or colon carcinoma received IL-2 at 3 X 10(6) units/m2/day on days 1-5 and 13-17, either by bolus injection every 8 h (q8h) or by continuous i.v. (CIV) administration. Peripheral blood mononuclear cells were harvested by leukapheresis on days 8, 9, and 10, were incubated in vitro for 5 days for generation of LAK cells, and were infused on days 13, 14, and 15. The first 11 patients were treated with IL-2 q8h, and the subsequent 13 patients were treated by CIV infusion. Toxicity consisted primarily of fever, chills, emesis, diarrhea, weight gain, and edema but did not require intensive care unit support and did not differ significantly between treatment groups. IL-2-induced lymphocytosis on day 8 was higher with CIV than with q8h administration with a mean lymphocyte count/microliter of 5610 +/- 700 (SE) versus 3300 +/- 500. Immunomodulatory changes observed on days 8 and 20 were also greater with CIV IL-2 and included an increase in peripheral blood mononuclear cell IL-2 receptor expression as well as a marked rise in the number of Leu-11+ and Leu-19+ peripheral blood mononuclear cells. The total leukapheresis yield per patient and total number of LAK cells infused per patient were higher with CIV than q8h administration, with 49.8 +/- 4.9 X 10(9) versus 39.4 +/- 5.4 X 10(9) and 42.6 +/- 5.0 X 10(9) versus 34.0 +/- 5.4 X 10(9), respectively. The cells infused displayed phenotypic evidence of activation and exhibited marked lytic reactivity to Daudi, Raji, and HT-144 targets. One complete and one minimal response were observed in 2 of 8 patients with metastatic renal cell carcinoma who received CIV IL-2 and LAK cells. The results show that IL-2 is more biologically active by CIV

  1. 10 CFR 30.70 - Schedule A-Exempt concentrations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... MATERIAL Schedules § 30.70 Schedule A—Exempt concentrations. Element (atomic number) Isotope Col. I Gas...: Many radioisotopes disintegrate into isotopes which are also radioactive. In expressing the concentrations in Schedule A, the activity stated is that of the parent isotope and takes into account...

  2. 10 CFR 30.70 - Schedule A-Exempt concentrations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... MATERIAL Schedules § 30.70 Schedule A—Exempt concentrations. Element (atomic number) Isotope Col. I Gas...: Many radioisotopes disintegrate into isotopes which are also radioactive. In expressing the concentrations in Schedule A, the activity stated is that of the parent isotope and takes into account...

  3. 10 CFR 30.70 - Schedule A-Exempt concentrations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... MATERIAL Schedules § 30.70 Schedule A—Exempt concentrations. Element (atomic number) Isotope Col. I Gas...: Many radioisotopes disintegrate into isotopes which are also radioactive. In expressing the concentrations in Schedule A, the activity stated is that of the parent isotope and takes into account...

  4. 15 CFR 712.4 - New Schedule 1 production facility.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ACTIVITIES INVOLVING SCHEDULE 1 CHEMICALS § 712.4 New Schedule 1 production facility. (a) Establishment of a...) of the CWCR, and you intend to begin production of Schedule 1 chemicals at your facility...

  5. 15 CFR 712.4 - New Schedule 1 production facility.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ACTIVITIES INVOLVING SCHEDULE 1 CHEMICALS § 712.4 New Schedule 1 production facility. (a) Establishment of a...) of the CWCR, and you intend to begin production of Schedule 1 chemicals at your facility...

  6. 15 CFR 712.4 - New Schedule 1 production facility.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ACTIVITIES INVOLVING SCHEDULE 1 CHEMICALS § 712.4 New Schedule 1 production facility. (a) Establishment of a...) of the CWCR, and you intend to begin production of Schedule 1 chemicals at your facility...

  7. 40 CFR 144.53 - Schedule of compliance.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... permit may, when appropriate, specify a schedule of compliance leading to compliance with the SDWA and... permit may be modified to contain a new or additional schedule leading to timely cessation of activities... termination date, the permit shall contain a schedule leading to termination which will ensure...

  8. Scheduling lessons learned from the Autonomous Power System

    NASA Technical Reports Server (NTRS)

    Ringer, Mark J.

    1992-01-01

    The Autonomous Power System (APS) project at NASA LeRC is designed to demonstrate the applications of integrated intelligent diagnosis, control, and scheduling techniques to space power distribution systems. The project consists of three elements: the Autonomous Power Expert System (APEX) for Fault Diagnosis, Isolation, and Recovery (FDIR); the Autonomous Intelligent Power Scheduler (AIPS) to efficiently assign activities start times and resources; and power hardware (Brassboard) to emulate a space-based power system. The AIPS scheduler was tested within the APS system. This scheduler is able to efficiently assign available power to the requesting activities and share this information with other software agents within the APS system in order to implement the generated schedule. The AIPS scheduler is also able to cooperatively recover from fault situations by rescheduling the affected loads on the Brassboard in conjunction with the APEX FDIR system. AIPS served as a learning tool and an initial scheduling testbed for the integration of FDIR and automated scheduling systems. Many lessons were learned from the AIPS scheduler and are now being integrated into a new scheduler called SCRAP (Scheduler for Continuous Resource Allocation and Planning). This paper will service three purposes: an overview of the AIPS implementation, lessons learned from the AIPS scheduler, and a brief section on how these lessons are being applied to the new SCRAP scheduler.

  9. The Milestones Passport: A Learner-Centered Application of the Milestone Framework to Prompt Real-Time Feedback in the Emergency Department

    PubMed Central

    Yarris, Lalena M.; Jones, David; Kornegay, Joshua G.; Hansen, Matthew

    2014-01-01

    Background In July 2013, emergency medicine residency programs implemented the Milestone assessment as part of the Next Accreditation System. Objective We hypothesized that applying the Milestone framework to real-time feedback in the emergency department (ED) could affect current feedback processes and culture. We describe the development and implementation of a Milestone-based, learner-centered intervention designed to prompt real-time feedback in the ED. Methods We developed and implemented the Milestones Passport, a feedback intervention incorporating subcompetencies, in our residency program in July 2013. Our primary outcomes were feasibility, including faculty and staff time and costs, number of documented feedback encounters in the first 2 months of implementation, and user-reported time required to complete the intervention. We also assessed learner and faculty acceptability. Results Development and implementation of the Milestones Passport required 10 hours of program coordinator time, 120 hours of software developer time, and 20 hours of faculty time. Twenty-eight residents and 34 faculty members generated 257 Milestones Passport feedback encounters. Most residents and faculty reported that the encounters required fewer than 5 minutes to complete, and 48% (12 of 25) of the residents and 68% (19 of 28) of faculty reported satisfaction with the Milestones Passport intervention. Faculty satisfaction with overall feedback in the ED improved after the intervention (93% versus 54%, P  =  .003), whereas resident satisfaction with feedback did not change significantly. Conclusions The Milestones Passport feedback intervention was feasible and acceptable to users; however, learner satisfaction with the Milestone assessment in the ED was modest. PMID:26279784

  10. Charting the Road to Competence: Developmental Milestones for Internal Medicine Residency Training

    PubMed Central

    Green, Michael L.; Aagaard, Eva M.; Caverzagie, Kelly J.; Chick, Davoren A.; Holmboe, Eric; Kane, Gregory; Smith, Cynthia D.; Iobst, William

    2009-01-01

    Background The Accreditation Council for Graduate Medical Education (ACGME) Outcome Project requires that residency program directors objectively document that their residents achieve competence in 6 general dimensions of practice. Intervention In November 2007, the American Board of Internal Medicine (ABIM) and the ACGME initiated the development of milestones for internal medicine residency training. ABIM and ACGME convened a 33-member milestones task force made up of program directors, experts in evaluation and quality, and representatives of internal medicine stakeholder organizations. This article reports on the development process and the resulting list of proposed milestones for each ACGME competency. Outcomes The task force adopted the Dreyfus model of skill acquisition as a framework the internal medicine milestones, and calibrated the milestones with the expectation that residents achieve, at a minimum, the “competency” level in the 5-step progression by the completion of residency. The task force also developed general recommendations for strategies to evaluate the milestones. Discussion The milestones resulting from this effort will promote competency-based resident education in internal medicine, and will allow program directors to track the progress of residents and inform decisions regarding promotion and readiness for independent practice. In addition, the milestones may guide curriculum development, suggest specific assessment strategies, provide benchmarks for resident self-directed assessment-seeking, and assist remediation by facilitating identification of specific deficits. Finally, by making explicit the profession's expectations for graduates and providing a degree of national standardization in evaluation, the milestones may improve public accountability for residency training. PMID:21975701

  11. Variations in Sexual Identity Milestones among Lesbians, Gay Men and Bisexuals

    PubMed Central

    Martos, Alexander; Nezhad, Sheila; Meyer, Ilan H.

    2016-01-01

    Despite a large body of literature covering sexual identity development milestones, we know little about differences or similarities in patterns of identity development among subgroups of the lesbian, gay, and bisexual (LGB) population. For this study, we assessed identity milestones for 396 LGB New Yorkers, ages 18–59. Sexual identity and disclosure milestones, were measured across gender, sexual identity, race/ethnicity, and age cohort subgroups of the LGB sample. Men experienced most sexual identity milestones earlier than women, but they tended to take more time between milestones. LGBs in younger age cohorts experienced sexual identity milestones and disclosure milestones earlier than the older cohorts. Bisexual people experienced sexual identity and disclosure milestones later than gay and lesbian people. Timing of coming out milestones did not differ by race/ethnicity. By comparing differences within subpopulations, the results of this study help build understanding of the varied identity development experiences of people who are often referred to collectively as “the LGB community.” LGB people face unique health and social challenges; a more complete understanding of variations among LGB people allows health professionals and social service providers to provide services that better fit the needs of LGB communities.

  12. Transportation Baseline Schedule

    SciTech Connect

    Fawcett, Ricky Lee; John, Mark Earl

    2000-01-01

    The “1999 National Transportation Program - Transportation Baseline Report” presents data that form a baseline to enable analysis and planning for future Department of Energy (DOE) Environmental Management (EM) waste/material transportation. The companion “1999 Transportation ‘Barriers’ Analysis” analyzes the data and identifies existing and potential problems that may prevent or delay transportation activities based on the data presented. The “1999 Transportation Baseline Schedule” (this report) uses the same data to provide an overview of the transportation activities of DOE EM waste/materials. This report can be used to identify areas where stakeholder interface is needed, and to communicate to stakeholders the quantity/schedule of shipments going through their area. Potential bottlenecks in the transportation system can be identified; the number of packages needed, and the capacity needed at receiving facilities can be planned. This report offers a visualization of baseline DOE EM transportation activities for the 11 major sites and the “Geologic Repository Disposal” site (GRD).

  13. Space station payload operations scheduling with ESP2

    NASA Technical Reports Server (NTRS)

    Stacy, Kenneth L.; Jaap, John P.

    1988-01-01

    The Mission Analysis Division of the Systems Analysis and Integration Laboratory at the Marshall Space Flight Center is developing a system of programs to handle all aspects of scheduling payload operations for Space Station. The Expert Scheduling Program (ESP2) is the heart of this system. The task of payload operations scheduling can be simply stated as positioning the payload activities in a mission so that they collect their desired data without interfering with other activities or violating mission constraints. ESP2 is an advanced version of the Experiment Scheduling Program (ESP) which was developed by the Mission Integration Branch beginning in 1979 to schedule Spacelab payload activities. The automatic scheduler in ESP2 is an expert system that embodies the rules that expert planners would use to schedule payload operations by hand. This scheduler uses depth-first searching, backtracking, and forward chaining techniques to place an activity so that constraints (such as crew, resources, and orbit opportunities) are not violated. It has an explanation facility to show why an activity was or was not scheduled at a certain time. The ESP2 user can also place the activities in the schedule manually. The program offers graphical assistance to the user and will advise when constraints are being violated. ESP2 also has an option to identify conflict introduced into an existing schedule by changes to payload requirements, mission constraints, and orbit opportunities.

  14. Advanced Reactors Transition Program Resource Loaded Schedule

    SciTech Connect

    GANTT, D.A.

    2000-01-12

    The Advanced Reactors Transition (ART) Resource Loaded Schedule (RLS) provides a cost and schedule baseline for managing the project elements within the ART Program. The Fast Flux Test Facility (FETF) activities are delineated through the end of FY 2000, assuming continued standby. The Nuclear Energy (NE) Legacies and Plutonium Recycle Test Reactor (PRTR) activities are delineated through the end of the deactivation process. This revision reflects the 19 Oct 1999 baseline.

  15. Advanced Reactors Transition Program Resource Loaded Schedule

    SciTech Connect

    BOWEN, W.W.

    1999-11-08

    The Advanced Reactors Transition (ART) Resource Loaded Schedule (RLS) provides a cost and schedule baseline for managing the project elements within the ART Program. The Fast Flux Test Facility (FFTF) activities are delineated through the end of FY 2000, assuming continued standby. The Nuclear Energy (NE) Legacies and Plutonium Recycle Test Reactor (PRTR) activities are delineated through the end of the deactivation process. This document reflects the 1 Oct 1999 baseline.

  16. Where do we go from here? Moving from systems-based practice process measures to true competency via developmental milestones.

    PubMed

    Martinez, Johanna; Phillips, Erica; Harris, Christina

    2014-01-01

    For many educators it has been challenging to meet the Accreditation Council for Graduate Medical Education's requirements for teaching systems-based practice (SBP). An additional layer of complexity for educators is evaluating competency in SBP, despite milestones and entrustable professional activities (EPAs). In order to address this challenge, the authors present the results of a literature review for how SBP is currently being taught and a series of recommendations on how to achieve competency in SBP for graduate medical trainees with the use of milestones. The literature review included 29 articles and demonstrated that only 28% of the articles taught more than one of the six core principles of SBP in a meaningful way. Only 7% of the articles received the highest grade of A. The authors summarize four guiding principles for creating a competency-based curriculum that is in alignment with the Next Accreditation System (NAS): 1) the curriculum needs to include all of the core principles in that competency, 2) the objectives of the curriculum should be driven by clinical outcomes, 3) the teaching modalities need to be interactive and clinically relevant, and 4) the evaluation process should be able to measure competency and be directly reflective of pertinent milestones and/or EPAs. This literature review and the provided guiding principles can guide other residency educators in their development of competency-based curricula that meets the standards of the NAS.

  17. Incremental Scheduling Engines: Cost Savings through Automation

    NASA Technical Reports Server (NTRS)

    Jaap, John; Phillips, Shaun

    2005-01-01

    As humankind embarks on longer space missions farther from home, the requirements and environments for scheduling the activities performed on these missions are changing. As we begin to prepare for these missions it is appropriate to evaluate the merits and applicability of the different types of scheduling engines. Scheduling engines temporally arrange tasks onto a timeline so that all constraints and ob.jectives are met and resources are not over-booked. Scheduling engines used to schedule space missions fall into three general categories: batch, mixed-initiative, and incremental. This paper, presents an assessment of the engine types, a discussion of the impact of human exploration of the moon and Mars on planning and scheduling, and the applicability of the different types of scheduling engines. This paper will pursue the hypothesis that incremental scheduling engines may have a place in the new environment; they have the potential to reduce cost, to improve the satisfaction of those who execute or benefit from a particular timeline (the customers), and to allow astronauts to plan their own tasks and those of their companion robots.

  18. Scheduling: Seven Period Day

    ERIC Educational Resources Information Center

    Williamson, Ronald

    2010-01-01

    Driven by stable or declining financial resources many school districts are considering the costs and benefits of a seven-period day. While there is limited evidence that any particular scheduling model has a greater impact on student learning than any other, it is clear that the school schedule is a tool that can significantly impact teacher…

  19. A Fluid Block Schedule

    ERIC Educational Resources Information Center

    Ubben, Gerald C.

    1976-01-01

    Achieving flexibility without losing student accountability is a challenge that faces every school. With a fluid block schedule, as described here, accountability is maintained without inhibiting flexibility. An additional advantage is that three levels of schedule decision making take some of the pressure off the principal. (Editor)

  20. Surviving Block Scheduling.

    ERIC Educational Resources Information Center

    Haley, Marjorie

    A discussion of block scheduling for second language instruction looks at the advantages and disadvantages and offers some suggestions for classroom management and course organization. It is argued that block scheduling may offer a potential solution to large classes, insufficient time for labs, too little individualized instruction; few…

  1. Fundamentals of School Scheduling.

    ERIC Educational Resources Information Center

    Schroth, Gwen

    The ability of the school administrator to schedule teachers' and students' time so that each receives the most from each school day has become an essential skill. This book has been prepared for school administrators at the elementary and middle school levels who need appropriate management techniques for scheduling students into classes. Chapter…

  2. Range Scheduling Aid (RSA)

    NASA Technical Reports Server (NTRS)

    Logan, J. R.; Pulvermacher, M. K.

    1991-01-01

    Range Scheduling Aid (RSA) is presented in the form of the viewgraphs. The following subject areas are covered: satellite control network; current and new approaches to range scheduling; MITRE tasking; RSA features; RSA display; constraint based analytic capability; RSA architecture; and RSA benefits.

  3. Mixed-Integer Formulations for Constellation Scheduling

    NASA Astrophysics Data System (ADS)

    Valicka, C.; Hart, W.; Rintoul, M.

    Remote sensing systems have expanded the set of capabilities available for and critical to national security. Cooperating, high-fidelity sensing systems and growing mission applications have exponentially increased the set of potential schedules. A definitive lack of advanced tools places an increased burden on operators, as planning and scheduling remain largely manual tasks. This is particularly true in time-critical planning activities where operators aim to accomplish a large number of missions through optimal utilization of single or multiple sensor systems. Automated scheduling through identification and comparison of alternative schedules remains a challenging problem applicable across all remote sensing systems. Previous approaches focused on a subset of sensor missions and do not consider ad-hoc tasking. We have begun development of a robust framework that leverages the Pyomo optimization modeling language for the design of a tool to assist sensor operators planning under the constraints of multiple concurrent missions and uncertainty. Our scheduling models have been formulated to address the stochastic nature of ad-hoc tasks inserted under a variety of scenarios. Operator experience is being leveraged to select appropriate model objectives. Successful development of the framework will include iterative development of high-fidelity mission models that consider and expose various schedule performance metrics. Creating this tool will aid time-critical scheduling by increasing planning efficiency, clarifying the value of alternative modalities uniquely provided by multi-sensor systems, and by presenting both sets of organized information to operators. Such a tool will help operators more quickly and fully utilize sensing systems, a high interest objective within the current remote sensing operations community. Preliminary results for mixed-integer programming formulations of a sensor scheduling problem will be presented. Assumptions regarding sensor geometry

  4. Mission Operations Planning and Scheduling System (MOPSS)

    NASA Technical Reports Server (NTRS)

    Wood, Terri; Hempel, Paul

    2011-01-01

    MOPSS is a generic framework that can be configured on the fly to support a wide range of planning and scheduling applications. It is currently used to support seven missions at Goddard Space Flight Center (GSFC) in roles that include science planning, mission planning, and real-time control. Prior to MOPSS, each spacecraft project built its own planning and scheduling capability to plan satellite activities and communications and to create the commands to be uplinked to the spacecraft. This approach required creating a data repository for storing planning and scheduling information, building user interfaces to display data, generating needed scheduling algorithms, and implementing customized external interfaces. Complex scheduling problems that involved reacting to multiple variable situations were analyzed manually. Operators then used the results to add commands to the schedule. Each architecture was unique to specific satellite requirements. MOPSS is an expert system that automates mission operations and frees the flight operations team to concentrate on critical activities. It is easily reconfigured by the flight operations team as the mission evolves. The heart of the system is a custom object-oriented data layer mapped onto an Oracle relational database. The combination of these two technologies allows a user or system engineer to capture any type of scheduling or planning data in the system's generic data storage via a GUI.

  5. Computerizing the Reference Desk Schedule.

    ERIC Educational Resources Information Center

    deHaas, Pat

    1983-01-01

    Discussion of the scheduling procedures of librarians' hours at the reference desk at the Rutherford Humanities and Social Sciences Library, University of Alberta, highlights services provided, the preference table system, and manual scheduling versus computer scheduling. (EJS)

  6. NASA Schedule Management Handbook

    NASA Technical Reports Server (NTRS)

    2011-01-01

    The purpose of schedule management is to provide the framework for time-phasing, resource planning, coordination, and communicating the necessary tasks within a work effort. The intent is to improve schedule management by providing recommended concepts, processes, and techniques used within the Agency and private industry. The intended function of this handbook is two-fold: first, to provide guidance for meeting the scheduling requirements contained in NPR 7120.5, NASA Space Flight Program and Project Management Requirements, NPR 7120.7, NASA Information Technology and Institutional Infrastructure Program and Project Requirements, NPR 7120.8, NASA Research and Technology Program and Project Management Requirements, and NPD 1000.5, Policy for NASA Acquisition. The second function is to describe the schedule management approach and the recommended best practices for carrying out this project control function. With regards to the above project management requirements documents, it should be noted that those space flight projects previously established and approved under the guidance of prior versions of NPR 7120.5 will continue to comply with those requirements until project completion has been achieved. This handbook will be updated as needed, to enhance efficient and effective schedule management across the Agency. It is acknowledged that most, if not all, external organizations participating in NASA programs/projects will have their own internal schedule management documents. Issues that arise from conflicting schedule guidance will be resolved on a case by case basis as contracts and partnering relationships are established. It is also acknowledged and understood that all projects are not the same and may require different levels of schedule visibility, scrutiny and control. Project type, value, and complexity are factors that typically dictate which schedule management practices should be employed.

  7. Certification of Completion of Level-2 Milestone 405: Deploy Next-Generation Data Management and Analysis Environment

    SciTech Connect

    Long, J W; Frank, R J; Brugger, E; Louis, S

    2004-07-28

    This summary report describes data management and visualization activities in the Advanced Simulation and Computing (ASC) program at Lawrence Livermore National Laboratory (LLNL). The report covers the period from approximately October 2003 to June 2004 and describes activities within the Visual Interactive Environment for Weapons Simulation (VIEWS) ASC program element. This report and the references herein are intended to document the completion of the following Level 2 Milestone from the ASC FY04-05 Implementation Plan, due at the end of Quarter 3 in FY04:

  8. Advanced Initiation Systems Manufacturing Level 2 Milestone Completion Summary

    SciTech Connect

    Chow, R; Schmidt, M

    2009-10-01

    Milestone Description - Advanced Initiation Systems Detonator Design and Prototype. Milestone Grading Criteria - Design new generation chip slapper detonator and manufacture a prototype using advanced manufacturing processes, such as all-dry chip metallization and solvent-less flyer coatings. The advanced processes have been developed for manufacturing detonators with high material compatibility and reliability to support future LEPs, e.g. the B61, and new weapons systems. Perform velocimetry measurements to determine slapper velocity as a function of flight distance. A prototype detonator assembly and stripline was designed for low-energy chip slappers. Pictures of the prototype detonator and stripline are shown. All-dry manufacturing processes were used to address compatibility issues. KCP metallized the chips in a physical vapor deposition system through precision-aligned shadow masks. LLNL deposited a solvent-less polyimide flyer with a processes called SLIP, which stands for solvent-less vapor deposition followed by in-situ polymerization. LANL manufactured the high-surface-area (HSA) high explosive (HE) pellets. Test fires of two chip slapper designs, radius and bowtie, were performed at LLNL in the High Explosives Application Facility (HEAF). Test fires with HE were conducted to establish the threshold firing voltages. pictures of the chip slappers before and after test fires are shown. Velocimetry tests were then performed to obtain slapper velocities at or above the threshold firing voltages. Figure 5 shows the slapper velocity as a function of distance and time at the threshold voltage, for both radius and bowtie bridge designs. Both designs were successful at initiating the HE at low energy levels. Summary of Accomplishments are: (1) All-dry process for chip manufacture developed; (2) Solventless process for slapper materials developed; (3) High-surface area explosive pellets developed; (4) High performance chip slappers developed; (5) Low-energy chip

  9. Certification of Completion of Item 2 of ASC FY07 Level-2 Milestone ID #2380

    SciTech Connect

    Lipari, D A

    2007-03-28

    This report documents the completion of Item 2 of the three milestone deliverables that comprise Milestone ID 2380: Deploy selected Tri-Lab resource manager at LLNL and develop support model. Specifically: LLNL will integrate and support a commercial resource manager software product at LLNL to be used across the tri-lab HPC facilities.

  10. Culture perfusion schedules influence the metabolic activity and granulocyte-macrophage colony-stimulating factor production rates of human bone marrow stromal cells.

    PubMed

    Caldwell, J; Palsson, B O; Locey, B; Emerson, S G

    1991-05-01

    The metabolic function and GM-CSF production rates of adherent human bone marrow stromal cells were investigated as functions of medium and serum feeding rates. A range of medium exchange schedules was studied, ranging from a typical Dexter culture protocol of one weekly medium exchange to a full media exchange daily, which more closely approximates what bone marrow cells experience in situ. Glucose consumption was found to be significantly higher at full daily exchange rate than at any other exchange schedule examined. However, the lactate yield on glucose was a constant, at 1.8 mol/mol, under all conditions considered. Differential serum vs. medium exchange experiment showed that both serum supply and medium nutrients were responsible for the altered behavior at high exchange rates. Glutamine consumption was found to be insignificant under all culture conditions examined. A change in exchange schedule from 50% daily medium exchange to full daily medium exchange after 14 days of culture was found to result in a transient production of GM-CSF and a change in metabolic behavior to resemble that of cultures which had full daily exchange from day one. These results suggest that both stromal cell metabolism and GM-CSF production are sensitive to medium exchange schedules. Taken together, the data presented indicate that attempts to model the function of human bone marrow in vitro may be well served by beginning with medium exchange schedules that more closely mimic the in vivo physiologic state of bone marrow. PMID:2040665

  11. Evidence-based milestone ages as a framework for developmental surveillance

    PubMed Central

    Dosman, Cara F; Andrews, Debbi; Goulden, Keith J

    2012-01-01

    Developmental surveillance is the process of monitoring child development over time to promote healthy development and to identify possible problems. Standardized developmental screeners have greater sensitivity than milestone-based history taking. Unfortunately, Canadian screening guidelines, to date, are sparse, logistical barriers to implementation have slowed uptake of screening tests and physicians continue to rely on milestones. When using clinical impression as a framework for surveillance, clinicians may not know when to consider a milestone delayed because developmental attainments exist within an age range and there is an absence of referenced percentiles on available published tables, which are particularly problematic for the cognitive and social-emotional sectors, which are less familiar to physicians. A novel, five-sector milestone framework with upper limits, referenced to the best available level of evidence, is presented. This framework may be used in teaching and may help physicians to better recognize failed milestones to facilitate early identification of children at risk for developmental disorders. PMID:24294064

  12. Evidence-based milestone ages as a framework for developmental surveillance.

    PubMed

    Dosman, Cara F; Andrews, Debbi; Goulden, Keith J

    2012-12-01

    Developmental surveillance is the process of monitoring child development over time to promote healthy development and to identify possible problems. Standardized developmental screeners have greater sensitivity than milestone-based history taking. Unfortunately, Canadian screening guidelines, to date, are sparse, logistical barriers to implementation have slowed uptake of screening tests and physicians continue to rely on milestones. When using clinical impression as a framework for surveillance, clinicians may not know when to consider a milestone delayed because developmental attainments exist within an age range and there is an absence of referenced percentiles on available published tables, which are particularly problematic for the cognitive and social-emotional sectors, which are less familiar to physicians. A novel, five-sector milestone framework with upper limits, referenced to the best available level of evidence, is presented. This framework may be used in teaching and may help physicians to better recognize failed milestones to facilitate early identification of children at risk for developmental disorders.

  13. Models of ratio schedule performance.

    PubMed

    Bizo, L A; Killeen, P R

    1997-07-01

    Predictions of P. R. Killeen's (1994) mathematical principles of reinforcement were tested for responding on ratio reinforcement schedules. The type of response key, the number of sessions per condition, and first vs. second half of a session had negligible effects on responding. Longer reinforcer durations and larger grain types engendered more responding, affecting primarily the parameter alpha (specific activation). Key pecking was faster than treadle pressing, affecting primarily the parameter delta (response time). Longer intertrial intervals led to higher overall response rates and shorter postreinforcement pauses and higher running rates, and ruled out some competing explanations. The treadle data required a distinction between the energetic requirements and rate-limiting properties of extended responses. The theory was extended to predict pause durations and run rates on ratio schedules.

  14. Prototype resupply scheduler

    NASA Technical Reports Server (NTRS)

    Tanner, Steve; Hughes, Angi; Byrd, Jim

    1987-01-01

    Resupply scheduling for the Space Station presents some formidable logistics problems. One of the most basic problems is assigning supplies to a series of shuttle resupply missions. A prototype logistics expert system which constructs resupply schedules was developed. This prototype is able to reconstruct feasible resupply plans. In addition, analysts can use the system to evaluate the impact of adding, deleting or modifying launches, cargo space, experiments, etc.

  15. Milestones in Medical Research, The Human Genome and ClinicalTrials.gov | NIH MedlinePlus the Magazine

    MedlinePlus

    ... turn Javascript on. Milestones in Medical Research, The Human Genome and ClinicalTrials.gov Past Issues / Fall 2010 ... milestone in understanding the genetic foundation of all human beings; the second, a comprehensive information service to ...

  16. A Picture-Based Activity Schedule Intervention to Teach Adults with Mild Intellectual Disability to Use an iPad during a Leisure Activity

    ERIC Educational Resources Information Center

    Chan, Jeffrey Michael; Lambdin, Lindsay; Graham, Kimberly; Fragale, Christina; Davis, Tonya

    2014-01-01

    Individuals with developmental disabilities have limited opportunities to participate in leisure activities, frequently due to lack of skills. The purpose of the current study was to teach three adults diagnosed with mild intellectual disability to use an iPad in the context of playing the video game Angry Birds. We used an adapted multiple…

  17. Milestone achievement and neurodevelopment of rural Amazonian toddlers (12 to 24 months) with different methylmercury and ethylmercury exposure.

    PubMed

    Dórea, José G; Marques, Rejane C; Abreu, Luciana

    2014-01-01

    Neurological outcomes (Gesell development schedules [GDS]), age of walking, and age of talking were studied in 299 toddlers (12 to 24 mo) in relation to environmental (fish consumption and tin mining) exposure. Exposure to fish methylmercury (MeHg) consumption and iatrogenic ethylmercury (EtHg) in Thimerosal-containing vaccines (TCV) was quantified in toddlers from two rural villages (n = 91, Itapuã; n = 218, Bom Futuro) respectively populated by fishers and cassiterite miners. Median total hair Hg (HHg) concentrations of infants from Itapuã (3.5 μg/g) were significantly higher than those of infants from Bom Futuro (2.2 μg/g). Median EtHg exposure from TCV was also significantly higher in toddlers from Itapuã (137.5 μg) than in those from Bom Futuro (112.5 μg). There were no significant differences between groups for any of the Gesell schedules; however, there were proportionally more compromised toddlers (GDS < 70) in Itapuã than Bom Futuro. Median age of talking was not statistically different but median age of walking was significantly higher in Bom Futuro. In toddlers from both villages, of fishers and miners, HHg concentrations were significantly correlated with family fish consumption. A logistic regression model was applied to all infants after classification into two groups: above or below the median Gesell schedules. Overall, there was no distinctive pattern of neurodevelopment associated with either HHg or EtHg exposure; however, nutritional status was significantly associated with GDS. In conclusion, milestone achievement was delayed in toddlers from tin-ore mining communities. Despite significantly higher exposure to both forms of organic Hg (MeHg from maternal fish consumption, and EtHg from TCV) in toddlers from the fishing village, significant differences were seen only among the proportions of most severely affected toddlers (GDS < 70).

  18. PLAN-IT: Scheduling assistant for solar system exploration

    NASA Technical Reports Server (NTRS)

    Dias, William C.; Henricks, Julia A.; Wong, Jennifer C.

    1987-01-01

    A frame-based expert scheduling system shell, PLAN-IT, is developed for spacecraft scheduling in the Request Integration Phase, using the Comet Rendezvous Asteroid Flyby (CRAF) mission as a development base. Basic, structured, and expert scheduling techniques are reviewed. Data elements such as activity representation and resource conflict representation are discussed. Resource constraints include minimum and maximum separation times between activities, percentage of time pointed at specific targets, and separation time between targeted intervals of a given activity. The different scheduling technique categories and the rationale for their selection are also considered.

  19. Effect of Uncertainty on Deterministic Runway Scheduling

    NASA Technical Reports Server (NTRS)

    Gupta, Gautam; Malik, Waqar; Jung, Yoon C.

    2012-01-01

    Active runway scheduling involves scheduling departures for takeoffs and arrivals for runway crossing subject to numerous constraints. This paper evaluates the effect of uncertainty on a deterministic runway scheduler. The evaluation is done against a first-come- first-serve scheme. In particular, the sequence from a deterministic scheduler is frozen and the times adjusted to satisfy all separation criteria; this approach is tested against FCFS. The comparison is done for both system performance (throughput and system delay) and predictability, and varying levels of congestion are considered. The modeling of uncertainty is done in two ways: as equal uncertainty in availability at the runway as for all aircraft, and as increasing uncertainty for later aircraft. Results indicate that the deterministic approach consistently performs better than first-come-first-serve in both system performance and predictability.

  20. Considerations for Using an Incremental Scheduler for Human Exploration Task Scheduling

    NASA Technical Reports Server (NTRS)

    Jaap, John; Phillips, Shaun

    2005-01-01

    As humankind embarks on longer space missions farther from home, the requirements and environments for scheduling the activities performed on these missions are changing. As we begin to prepare for these missions it is appropriate to evaluate the merits and applicability of the different types of scheduling engines. Scheduling engines temporally arrange tasks onto a timeline so that all constraints and objectives are met and resources are not overbooked. Scheduling engines used to schedule space missions fall into three general categories: batch, mixed-initiative, and incremental. This paper presents an assessment of the engine types, a discussion of the impact of human exploration of the moon and Mars on planning and scheduling, and the applicability of the different types of scheduling engines. This paper will pursue the hypothesis that incremental scheduling engines may have a place in the new environment; they have the potential to reduce cost, to improve the satisfaction of those who execute or benefit from a particular timeline (the customers), and to allow astronauts to plan their own tasks.

  1. Automated Scheduling Via Artificial Intelligence

    NASA Technical Reports Server (NTRS)

    Biefeld, Eric W.; Cooper, Lynne P.

    1991-01-01

    Artificial-intelligence software that automates scheduling developed in Operations Mission Planner (OMP) research project. Software used in both generation of new schedules and modification of existing schedules in view of changes in tasks and/or available resources. Approach based on iterative refinement. Although project focused upon scheduling of operations of scientific instruments and other equipment aboard spacecraft, also applicable to such terrestrial problems as scheduling production in factory.

  2. Constraint-based scheduling

    NASA Technical Reports Server (NTRS)

    Zweben, Monte

    1991-01-01

    The GERRY scheduling system developed by NASA Ames with assistance from the Lockheed Space Operations Company, and the Lockheed Artificial Intelligence Center, uses a method called constraint based iterative repair. Using this technique, one encodes both hard rules and preference criteria into data structures called constraints. GERRY repeatedly attempts to improve schedules by seeking repairs for violated constraints. The system provides a general scheduling framework which is being tested on two NASA applications. The larger of the two is the Space Shuttle Ground Processing problem which entails the scheduling of all inspection, repair, and maintenance tasks required to prepare the orbiter for flight. The other application involves power allocations for the NASA Ames wind tunnels. Here the system will be used to schedule wind tunnel tests with the goal of minimizing power costs. In this paper, we describe the GERRY system and its applications to the Space Shuttle problem. We also speculate as to how the system would be used for manufacturing, transportation, and military problems.

  3. Constraint-based scheduling

    NASA Technical Reports Server (NTRS)

    Zweben, Monte

    1991-01-01

    The GERRY scheduling system developed by NASA Ames with assistance from the Lockheed Space Operations Company, and the Lockheed Artificial Intelligence Center, uses a method called constraint-based iterative repair. Using this technique, one encodes both hard rules and preference criteria into data structures called constraints. GERRY repeatedly attempts to improve schedules by seeking repairs for violated constraints. The system provides a general scheduling framework which is being tested on two NASA applications. The larger of the two is the Space Shuttle Ground Processing problem which entails the scheduling of all the inspection, repair, and maintenance tasks required to prepare the orbiter for flight. The other application involves power allocation for the NASA Ames wind tunnels. Here the system will be used to schedule wind tunnel tests with the goal of minimizing power costs. In this paper, we describe the GERRY system and its application to the Space Shuttle problem. We also speculate as to how the system would be used for manufacturing, transportation, and military problems.

  4. Constraint-based scheduling

    NASA Technical Reports Server (NTRS)

    Zweben, Monte

    1993-01-01

    The GERRY scheduling system developed by NASA Ames with assistance from the Lockheed Space Operations Company, and the Lockheed Artificial Intelligence Center, uses a method called constraint-based iterative repair. Using this technique, one encodes both hard rules and preference criteria into data structures called constraints. GERRY repeatedly attempts to improve schedules by seeking repairs for violated constraints. The system provides a general scheduling framework which is being tested on two NASA applications. The larger of the two is the Space Shuttle Ground Processing problem which entails the scheduling of all the inspection, repair, and maintenance tasks required to prepare the orbiter for flight. The other application involves power allocation for the NASA Ames wind tunnels. Here the system will be used to schedule wind tunnel tests with the goal of minimizing power costs. In this paper, we describe the GERRY system and its application to the Space Shuttle problem. We also speculate as to how the system would be used for manufacturing, transportation, and military problems.

  5. Geo-Informatics in India: Major Milestones and Present Scenario

    NASA Astrophysics Data System (ADS)

    Gupta, S.; Karnatak, H.; Raju, P. L. N.

    2016-06-01

    Geo-informatics has emerged globally as a useful tool to address spatial problems with significant societal implications that require integrative and innovative approaches for analysis, modelling, managing, and archiving of extensive and diverse data sets. Breakneck technological development and availability of satellite based data and information services in public domain along with real time geo-data n through participatory approaches, in the two last decades have led to a sea-change in our know-how of our natural resources and their effective management at various levels. It has led to a realization that every phenomena and requirement in our day to day life has some spatial, or geographic component that can be predicted and governed more effectively through geoinformatics tool. India also has come a long way in effective utilization of geoinformatics for various applications. This quantum leap owes its foundation in a humble beginning about half century back and almost parallel developments in the country's space programme to a current level where it touches almost all areas of life and living. Though geoinformatics technology (GIT) is believed to reach satisfactory level in the country, Indian geospatial community faces critical challenges with respect to research, education and training along with enhanced the access to the stakeholders and mobilization of the workforce, that are crucial in further penetration of this technology in context to India's development. In this paper we have critically reviewed milestones of GI development and its current utilization status in Indian context.

  6. Scheduling with genetic algorithms

    NASA Technical Reports Server (NTRS)

    Fennel, Theron R.; Underbrink, A. J., Jr.; Williams, George P. W., Jr.

    1994-01-01

    In many domains, scheduling a sequence of jobs is an important function contributing to the overall efficiency of the operation. At Boeing, we develop schedules for many different domains, including assembly of military and commercial aircraft, weapons systems, and space vehicles. Boeing is under contract to develop scheduling systems for the Space Station Payload Planning System (PPS) and Payload Operations and Integration Center (POIC). These applications require that we respect certain sequencing restrictions among the jobs to be scheduled while at the same time assigning resources to the jobs. We call this general problem scheduling and resource allocation. Genetic algorithms (GA's) offer a search method that uses a population of solutions and benefits from intrinsic parallelism to search the problem space rapidly, producing near-optimal solutions. Good intermediate solutions are probabalistically recombined to produce better offspring (based upon some application specific measure of solution fitness, e.g., minimum flowtime, or schedule completeness). Also, at any point in the search, any intermediate solution can be accepted as a final solution; allowing the search to proceed longer usually produces a better solution while terminating the search at virtually any time may yield an acceptable solution. Many processes are constrained by restrictions of sequence among the individual jobs. For a specific job, other jobs must be completed beforehand. While there are obviously many other constraints on processes, it is these on which we focussed for this research: how to allocate crews to jobs while satisfying job precedence requirements and personnel, and tooling and fixture (or, more generally, resource) requirements.

  7. Intelligent retail logistics scheduling

    SciTech Connect

    Rowe, J.; Jewers, K.; Codd, A.; Alcock, A.

    1996-12-31

    The Supply Chain Integrated Ordering Network (SCION) Depot Bookings system automates the planning and scheduling of perishable and non-perishable commodities and the vehicles that carry them into J. Sainsbury depots. This is a strategic initiative, enabling the business to make the key move from weekly to daily ordering. The system is mission critical, managing the inwards flow of commodities from suppliers into J. Sainsbury`s depots. The system leverages Al techniques to provide a business solution that meets challenging functional and performance needs. The SCION Depot Bookings system is operational providing schedules for 22 depots across the UK.

  8. Managing temporal relations in the MAESTRO scheduling system

    NASA Technical Reports Server (NTRS)

    Britt, Daniel L.

    1991-01-01

    A set of viewgraphs on managing temporal relations in the MAESTRO scheduling system are given. The viewgraphs present information on such topics as why scheduling is hard, managing temporal relations, constraints on the placement of a single activity, constraints between activities, soft constraints (such as preferences), and contingency handling.

  9. Milestone Age Affects the Role of Health and Emotions in Life Satisfaction: A Preliminary Inquiry

    PubMed Central

    Miron-Shatz, Talya; Bhargave, Rajesh; Doniger, Glen M.

    2015-01-01

    Jill turns 40. Should this change how she evaluates her life, and would a similar change occur when she turns 41? Milestone age (e.g., 30, 40, 50)—a naturally occurring feature in personal timelines—has received much attention is popular culture, but little attention in academic inquiry. This study examines whether milestone birthdays change the way people evaluate their life. We show that life outlook is impacted by this temporal landmark, which appears to punctuate people’s mental maps of their life cycle. At these milestone junctures, people take stock of where they stand and have a more evaluative perspective towards their lives when making life satisfaction judgments. Correspondingly, they place less emphasis on daily emotional experiences. We find that milestone agers (vs. other individuals) place greater weight on health satisfaction and BMI and lesser weight on daily positive emotions in their overall life satisfaction judgments, whereas negative emotions remain influential. PMID:26244348

  10. Milestone Age Affects the Role of Health and Emotions in Life Satisfaction: A Preliminary Inquiry.

    PubMed

    Miron-Shatz, Talya; Bhargave, Rajesh; Doniger, Glen M

    2015-01-01

    Jill turns 40. Should this change how she evaluates her life, and would a similar change occur when she turns 41? Milestone age (e.g., 30, 40, 50)--a naturally occurring feature in personal timelines--has received much attention is popular culture, but little attention in academic inquiry. This study examines whether milestone birthdays change the way people evaluate their life. We show that life outlook is impacted by this temporal landmark, which appears to punctuate people's mental maps of their life cycle. At these milestone junctures, people take stock of where they stand and have a more evaluative perspective towards their lives when making life satisfaction judgments. Correspondingly, they place less emphasis on daily emotional experiences. We find that milestone agers (vs. other individuals) place greater weight on health satisfaction and BMI and lesser weight on daily positive emotions in their overall life satisfaction judgments, whereas negative emotions remain influential.

  11. Drive theory and home run milestones in baseball: an historical analysis.

    PubMed

    Goldschmied, Nadav; Harris, Michael; Vira, Damien; Kowalczyk, Jason

    2014-02-01

    The purpose of this investigation was to test whether the performance of the home run hitters in Major League Baseball adhered to predictions of Drive Theory. 24 baseball players who have hit at least 505 home runs were included in the sample. Their performance was assessed around the time in which they reached a significant home run career milestone, operationalized as either 500 or 600 home runs, or surpassing the league's home run record. As predicted, the players were found to require significantly more at-bats to complete the 5 home runs before the milestone, when stress was assumed to be mounting, than the 5 home runs after the milestone. In contrast, those players who reached the personal landmark from 1988 (the suspected commencement of the so-called "Steroid Era") onwards required the same number of at-bats before and after the milestone.

  12. Parent Interview Schedule.

    ERIC Educational Resources Information Center

    Purdue Univ., Lafayette, IN. Educational Research Center.

    This 116-item interview schedule designed for parents who failed to respond to the Questionnaire for Parents, is individually administered to the mother of the child of elementary school age. It consists of scales measuring 14 parent variables plus a section devoted to demographic variables: (1) parent's achievement aspirations for the child, (2)…

  13. CMS multicore scheduling strategy

    SciTech Connect

    Perez-Calero Yzquierdo, Antonio; Hernandez, Jose; Holzman, Burt; Majewski, Krista; McCrea, Alison

    2014-01-01

    In the next years, processor architectures based on much larger numbers of cores will be most likely the model to continue 'Moore's Law' style throughput gains. This not only results in many more jobs in parallel running the LHC Run 1 era monolithic applications, but also the memory requirements of these processes push the workernode architectures to the limit. One solution is parallelizing the application itself, through forking and memory sharing or through threaded frameworks. CMS is following all of these approaches and has a comprehensive strategy to schedule multicore jobs on the GRID based on the glideinWMS submission infrastructure. The main component of the scheduling strategy, a pilot-based model with dynamic partitioning of resources that allows the transition to multicore or whole-node scheduling without disallowing the use of single-core jobs, is described. This contribution also presents the experiences made with the proposed multicore scheduling schema and gives an outlook of further developments working towards the restart of the LHC in 2015.

  14. CMS multicore scheduling strategy

    NASA Astrophysics Data System (ADS)

    Pérez-Calero Yzquierdo, Antonio; Hernández, Jose; Holzman, Burt; Majewski, Krista; McCrea, Alison; Cms Collaboration

    2014-06-01

    In the next years, processor architectures based on much larger numbers of cores will be most likely the model to continue "Moore's Law" style throughput gains. This not only results in many more jobs in parallel running the LHC Run 1 era monolithic applications, but also the memory requirements of these processes push the workernode architectures to the limit. One solution is parallelizing the application itself, through forking and memory sharing or through threaded frameworks. CMS is following all of these approaches and has a comprehensive strategy to schedule multicore jobs on the GRID based on the glideinWMS submission infrastructure. The main component of the scheduling strategy, a pilot-based model with dynamic partitioning of resources that allows the transition to multicore or whole-node scheduling without disallowing the use of single-core jobs, is described. This contribution also presents the experiences made with the proposed multicore scheduling schema and gives an outlook of further developments working towards the restart of the LHC in 2015.

  15. Class Schedules--Computer Loaded or Student Self-Scheduled?

    ERIC Educational Resources Information Center

    Wall, Edward F.

    1979-01-01

    In the two-step process of student scheduling, the initial phase of course selection is the most important. At Chesterton High School in Indiana, student self-scheduling is preferred over computer loading. (Author/MLF)

  16. MILESTONES AND FUTURE DIRECTIONS IN THE SOLVENT EXTRACTION OF CAESIUM

    SciTech Connect

    Moyer, Bruce A

    2011-01-01

    The remarkable development of solvent-extraction (SX) chemistry for caesium separation over the past half a century as driven by the needs of the nuclear industry now constitutes an instructive case study in exploring the limits of selectivity and cycle efficiency in SX. In this review, key milestones in the pursuit of both fundamentals and applications of caesium extraction will be highlighted along with a look at future prospects. The high-yield fission-product 137Cs constitutes a major fraction of the radioactivity in nuclear wastes, and in view of its heat production, environmental mobility, radiation hazard, and even uses as a radiation source, methods have long been sought for its separation. Toward this end, the evolving science has been challenged by daunting requirements for decontamination in the presence of high concentrations of competing cations, and demands for small footprint, modular design, and high throughput place a premium on selectivity and efficiency. Fortunately, the science has also benefited from the peculiar economics of nuclear separations, which have afforded the development of wonderfully sophisticated reagents. With its location in the lower left side of the periodic table, the Cs+ cation has the distinction of having the lowest charge density of any metal cation except short-lived francium. For practical purposes, Cs+ is thus the least hydrated and, in principle, the most directly extractable metal cation. Technologies employing liquid-liquid cation exchange with very large, durable anions like those from the dicarbollide family have therefore been quite effective based solely on solvation principles. Alternatively, researchers have turned to macrocyclic coordinating extractants, such as calix-crown ethers, following principles of molecular recognition, with dramatic results. Overall, strides continue along these lines, though it is apparent that caesium SX has reached a state of excellent fundamental understanding and technical

  17. Milestones Contributing to the Evolution of Craniofacial Surgery.

    PubMed

    Tadisina, Kashyap Komarraju; Orra, Susan; Gharb, Bahar Bassiri; Rampazzo, Antonio; Papay, Francis; Zins, James E

    2015-11-01

    Craniofacial surgery (CFS) has a rich history of collaboration with a wide variety of surgical and nonsurgical specialties. This has resulted in a large volume of publications across this spectrum of subspecialties cataloging the advancements across the field. The authors aim to analyze the characteristics of the most cited articles in CFS. A literature search was performed using the Thomson/Reuters Web of Knowledge database to identify the top 50 most cited articles in CFS. The articles were analyzed for journal distribution, total citations, year of publication, citations per year, number of authors, type of article, institution, departmental affiliation, national affiliation, and top contributors. The articles were extracted from an assortment of 21 journals. The number of citations per article ranged from 115 to 1092 (average of 185). Forty-eight percent of articles were published in the 1990s, and 22% in the 2000s. The average number of years since publication until the present time was 21.34 (range 6-45 y). The most cited article (1092 citations and 52 citations/y) was an article by McCarthy et al on human mandible lengthening via gradual distraction. Departmental distribution indicated that the majority were attributable to departments of Plastic and Reconstructive Surgery for 21 articles (42%). Twenty articles were categorized under cranial defect/bone substitutes, 12 under craniosynostosis, 7 under surgical modeling, 6 under distraction osteogenesis, and the remaining 5 under other. These articles qualitatively represent important milestones in CFS. This study affirms the potential value of "number of citations" as a meaningful metric when assessing the importance of an article within CFS.

  18. ALMA Achieves Major Milestone With Antenna-Link Success

    NASA Astrophysics Data System (ADS)

    2007-03-01

    The Atacama Large Millimeter/submillimeter Array (ALMA), an international telescope project, reached a major milestone on March 2, when two ALMA prototype antennas were first linked together as an integrated system to observe an astronomical object. The milestone achievement, technically termed "First Fringes," came at the ALMA Test Facility (ATF) on the grounds of the National Radio Astronomy Observatory's (NRAO) Very Large Array (VLA) radio telescope in New Mexico. NRAO is a facility of the National Science Foundation (NSF), managed by Associated Universities, Incorporated (AUI). AUI also is designated by NSF as the North American Executive for ALMA. ALMA Test Facility ALMA Test Facility, New Mexico: VertexRSI antenna, left; AEC antenna, right. CREDIT: Drew Medlin, NRAO/AUI/NSF Click on image for page of graphics and full information Faint radio waves emitted by the planet Saturn were collected by the two ALMA antennas, then processed by new, state-of-the-art electronics to turn the two antennas into a single, high-resolution telescope system, called an interferometer. Such pairs of antennas are the basic building blocks of multi-antenna imaging systems such as ALMA and the VLA. In such a system, each antenna is combined electronically with every other antenna to form a multitude of pairs. Each pair contributes unique information that is used to build a highly-detailed image of the astronomical object under observation. When completed in 2012, ALMA will have 66 antennas. The successful Saturn observation began at 7:13 p.m., U.S. Mountain Time Friday (0213 UTC Saturday). The planet's radio emissions at a frequency of 104 GigaHertz (GHz) were tracked by the ALMA system for more than an hour. "Our congratulations go to the dedicated team of scientists, engineers and technicians who produced this groundbreaking achievement for ALMA. Much hard work and many long hours went into this effort, and we appreciate it all. This team should be very proud today," said NRAO

  19. Completable scheduling: An integrated approach to planning and scheduling

    NASA Technical Reports Server (NTRS)

    Gervasio, Melinda T.; Dejong, Gerald F.

    1992-01-01

    The planning problem has traditionally been treated separately from the scheduling problem. However, as more realistic domains are tackled, it becomes evident that the problem of deciding on an ordered set of tasks to achieve a set of goals cannot be treated independently of the problem of actually allocating resources to the tasks. Doing so would result in losing the robustness and flexibility needed to deal with imperfectly modeled domains. Completable scheduling is an approach which integrates the two problems by allowing an a priori planning module to defer particular planning decisions, and consequently the associated scheduling decisions, until execution time. This allows a completable scheduling system to maximize plan flexibility by allowing runtime information to be taken into consideration when making planning and scheduling decision. Furthermore, through the criteria of achievability placed on deferred decision, a completable scheduling system is able to retain much of the goal-directedness and guarantees of achievement afforded by a priori planning. The completable scheduling approach is further enhanced by the use of contingent explanation-based learning, which enables a completable scheduling system to learn general completable plans from example and improve its performance through experience. Initial experimental results show that completable scheduling outperforms classical scheduling as well as pure reactive scheduling in a simple scheduling domain.

  20. Scheduling techniques in the Request Oriented Scheduling Engine (ROSE)

    NASA Technical Reports Server (NTRS)

    Zoch, David R.

    1991-01-01

    Scheduling techniques in the ROSE are presented in the form of the viewgraphs. The following subject areas are covered: agenda; ROSE summary and history; NCC-ROSE task goals; accomplishments; ROSE timeline manager; scheduling concerns; current and ROSE approaches; initial scheduling; BFSSE overview and example; and summary.

  1. Distributed project scheduling at NASA: Requirements for manual protocols and computer-based support

    NASA Technical Reports Server (NTRS)

    Richards, Stephen F.

    1992-01-01

    The increasing complexity of space operations and the inclusion of interorganizational and international groups in the planning and control of space missions lead to requirements for greater communication, coordination, and cooperation among mission schedulers. These schedulers must jointly allocate scarce shared resources among the various operational and mission oriented activities while adhering to all constraints. This scheduling environment is complicated by such factors as the presence of varying perspectives and conflicting objectives among the schedulers, the need for different schedulers to work in parallel, and limited communication among schedulers. Smooth interaction among schedulers requires the use of protocols that govern such issues as resource sharing, authority to update the schedule, and communication of updates. This paper addresses the development and characteristics of such protocols and their use in a distributed scheduling environment that incorporates computer-aided scheduling tools. An example problem is drawn from the domain of Space Shuttle mission planning.

  2. Scheduling Future Water Supply Investments Under Uncertainty

    NASA Astrophysics Data System (ADS)

    Huskova, I.; Matrosov, E. S.; Harou, J. J.; Kasprzyk, J. R.; Reed, P. M.

    2014-12-01

    Uncertain hydrological impacts of climate change, population growth and institutional changes pose a major challenge to planning of water supply systems. Planners seek optimal portfolios of supply and demand management schemes but also when to activate assets whilst considering many system goals and plausible futures. Incorporation of scheduling into the planning under uncertainty problem strongly increases its complexity. We investigate some approaches to scheduling with many-objective heuristic search. We apply a multi-scenario many-objective scheduling approach to the Thames River basin water supply system planning problem in the UK. Decisions include which new supply and demand schemes to implement, at what capacity and when. The impact of different system uncertainties on scheme implementation schedules are explored, i.e. how the choice of future scenarios affects the search process and its outcomes. The activation of schemes is influenced by the occurrence of extreme hydrological events in the ensemble of plausible scenarios and other factors. The approach and results are compared with a previous study where only the portfolio problem is addressed (without scheduling).

  3. Surprise Benefits of Arena Scheduling

    ERIC Educational Resources Information Center

    Surloff, Andrew

    2008-01-01

    One of the most challenging tasks a principal must accomplish every year is the construction of the master schedule. Free from the magnetic scheduling boards and wall charts of yesteryear, principals now have technological tools--such as programs that offer schools solutions for their scheduling needs--that can save time and enable them to work…

  4. Scheduling and Achievement. Research Brief

    ERIC Educational Resources Information Center

    Walker, Karen

    2006-01-01

    To use a block schedule or a traditional schedule? Which structure will produce the best and highest achievement rates for students? The research is mixed on this due to numerous variables such as: (1) socioeconomic levels; (2) academic levels; (3) length of time a given schedule has been in operation; (4) strategies being used in the classrooms;…

  5. FlexMod Scheduling Redux

    ERIC Educational Resources Information Center

    Murray, Shannon

    2008-01-01

    Flexible modular scheduling (flex mod)--a schedule philosophy and system that has been in place at Wausau West High School in Wausau, Wisconsin, for the last 35 years and aligns nicely with current research on student learning--is getting more and more attention from high school administrators across the country. Flexible modular scheduling was…

  6. Flexible Scheduling: Making the Transition

    ERIC Educational Resources Information Center

    Creighton, Peggy Milam

    2008-01-01

    Citing literature that supports the benefits of flexible scheduling on student achievement, the author exhorts readers to campaign for flexible scheduling in their library media centers. She suggests tips drawn from the work of Graziano (2002), McGregor (2006) and Stripling (1997) for making a smooth transition from fixed to flexible scheduling:…

  7. Scheduling a C-Section

    MedlinePlus

    ... Labor & birth > Scheduling a c-section Scheduling a c-section E-mail to a friend Please fill ... develop before she’s born. Why can scheduling a c-section for non-medical reasons be a problem? ...

  8. APGEN Scheduling: 15 Years of Experience in Planning Automation

    NASA Technical Reports Server (NTRS)

    Maldague, Pierre F.; Wissler, Steve; Lenda, Matthew; Finnerty, Daniel

    2014-01-01

    In this paper, we discuss the scheduling capability of APGEN (Activity Plan Generator), a multi-mission planning application that is part of the NASA AMMOS (Advanced Multi- Mission Operations System), and how APGEN scheduling evolved over its applications to specific Space Missions. Our analysis identifies two major reasons for the successful application of APGEN scheduling to real problems: an expressive DSL (Domain-Specific Language) for formulating scheduling algorithms, and a well-defined process for enlisting the help of auxiliary modeling tools in providing high-fidelity, system-level simulations of the combined spacecraft and ground support system.

  9. 75 FR 42831 - Proposed Collection; Comment Request for Form 1065, Schedule C, Schedule D, Schedule K-1...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-22

    ... Items), Schedule L (Balance Sheets per Books), Schedule M-1 (Reconciliation of Income (Loss) per Books.... (Schedule K-1), Balance Sheets per Books (Schedule L), Reconciliation of Income (Loss) per Books With...

  10. Revisiting conjugate schedules.

    PubMed

    MacAleese, Kenneth R; Ghezzi, Patrick M; Rapp, John T

    2015-07-01

    The effects of conjugate reinforcement on the responding of 13 college students were examined in three experiments. Conjugate reinforcement was provided via key presses that changed the clarity of pictures displayed on a computer monitor in a manner proportional to the rate of responding. Experiment 1, which included seven parameters of clarity change per response, revealed that responding decreased as the percentage clarity per response increased for all five participants. These results indicate that each participant's responding was sensitive to intensity change, which is a parameter of conjugate reinforcement schedules. Experiment 2 showed that responding increased during conjugate reinforcement phases and decreased during extinction phases for all four participants. Experiment 3 also showed that responding increased during conjugate reinforcement and further showed that responding decreased during a conjugate negative punishment condition for another four participants. Directions for future research with conjugate schedules are briefly discussed. PMID:26150349

  11. Revisiting conjugate schedules.

    PubMed

    MacAleese, Kenneth R; Ghezzi, Patrick M; Rapp, John T

    2015-07-01

    The effects of conjugate reinforcement on the responding of 13 college students were examined in three experiments. Conjugate reinforcement was provided via key presses that changed the clarity of pictures displayed on a computer monitor in a manner proportional to the rate of responding. Experiment 1, which included seven parameters of clarity change per response, revealed that responding decreased as the percentage clarity per response increased for all five participants. These results indicate that each participant's responding was sensitive to intensity change, which is a parameter of conjugate reinforcement schedules. Experiment 2 showed that responding increased during conjugate reinforcement phases and decreased during extinction phases for all four participants. Experiment 3 also showed that responding increased during conjugate reinforcement and further showed that responding decreased during a conjugate negative punishment condition for another four participants. Directions for future research with conjugate schedules are briefly discussed.

  12. HUBBLE PHOTOGRAPHS WARPED GALAXY AS CAMERA PASSES MILESTONE

    NASA Technical Reports Server (NTRS)

    2002-01-01

    observations of ESO 510-G13, WFPC2 passed the milestone of taking its 100,000th image since its installation in the telescope by shuttle astronauts in 1993. Image Credit: NASA and the Hubble Heritage Team (STScI/AURA) Acknowledgment: C. Conselice (U. Wisconsin/STScI)

  13. Traditional/Block Scheduling, Gender, and Test Scores in College Biology Course

    ERIC Educational Resources Information Center

    Huelskamp, Diana

    2014-01-01

    Block scheduling is the reallocation of a school day into longer class sessions to allow for more active teaching strategies and active engagement of students, in the effort to increase student performance. Various types of block scheduling exist. Traditional scheduling is when the school day is divided into six to eight sessions, with each…

  14. ALMA Telescope Passes Major Milestone with Successful Antenna Link

    NASA Astrophysics Data System (ADS)

    2009-05-01

    The Atacama Large Millimeter/submillimeter Array (ALMA), an immense international telescope project under construction in northern Chile, reached a major milestone on April 30, when two ALMA antennas were linked together as an integrated system to observe an astronomical object for the first time. The milestone achievement, technically termed "First Fringes," came at ALMA’s Operations Support Facility, 9,500 feet above sea level. Faint radio waves emitted by the planet Mars were collected by the two 12-meter diameter ALMA antennas, then processed by state-of-the-art electronics to turn the two antennas into a single, high-resolution telescope system, called an interferometer. Such pairs of antennas are the basic building blocks of imaging systems that enable radio telescopes to deliver pictures that approach or even exceed the resolving power of visible light telescopes. In such a system, each antenna is combined electronically with every other antenna to form a multitude of antenna pairs. Each pair contributes unique information that is used to build a highly-detailed image of the astronomical object under observation. When completed early in the next decade, ALMA’s 66 antennas will provide over a thousand such antenna pairings, with distances between antennas exceeding ten miles. This will enable ALMA to see with a sharpness surpassing that of the best space telescopes. The antennas will operate at an altitude of 16,500 feet, high above the OSF, in one of the best locations on Earth for millimeter-wavelength astronomy, the Chajnantor Plateau in Chile’s Atacama Desert. Last week’s successful Mars observation was conducted at an observing frequency of 104.2 GHz. Astronomers measured the distinctive varying “fringes” detected by the interferometer as the planet moved across the sky. “This is a great success,” said Adrian Russell, North American ALMA Project Director at the National Radio Astronomy Observatory (NRAO), “not because we observed a

  15. 30 CFR 816.64 - Use of explosives: Blasting schedule.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 3 2013-07-01 2013-07-01 false Use of explosives: Blasting schedule. 816.64... ACTIVITIES § 816.64 Use of explosives: Blasting schedule. (a) General requirements. (1) The operator shall... specific areas in which blasting will take place; (3) Dates and time periods when explosives are to...

  16. 30 CFR 816.64 - Use of explosives: Blasting schedule.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 3 2012-07-01 2012-07-01 false Use of explosives: Blasting schedule. 816.64... ACTIVITIES § 816.64 Use of explosives: Blasting schedule. (a) General requirements. (1) The operator shall... specific areas in which blasting will take place; (3) Dates and time periods when explosives are to...

  17. 30 CFR 816.64 - Use of explosives: Blasting schedule.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 3 2011-07-01 2011-07-01 false Use of explosives: Blasting schedule. 816.64... ACTIVITIES § 816.64 Use of explosives: Blasting schedule. (a) General requirements. (1) The operator shall... specific areas in which blasting will take place; (3) Dates and time periods when explosives are to...

  18. 30 CFR 816.64 - Use of explosives: Blasting schedule.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 3 2014-07-01 2014-07-01 false Use of explosives: Blasting schedule. 816.64... ACTIVITIES § 816.64 Use of explosives: Blasting schedule. (a) General requirements. (1) The operator shall... specific areas in which blasting will take place; (3) Dates and time periods when explosives are to...

  19. 30 CFR 816.64 - Use of explosives: Blasting schedule.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Use of explosives: Blasting schedule. 816.64... ACTIVITIES § 816.64 Use of explosives: Blasting schedule. (a) General requirements. (1) The operator shall... specific areas in which blasting will take place; (3) Dates and time periods when explosives are to...

  20. FINAL REPORT: SUNSHINE STATE SOLAR GRID INITIATIVE (SUNGRIN) PHASE 1 (Critical Milestone Review Version)

    SciTech Connect

    Meeker, Rick; Steurer, Mischa; Li, Hui; Edrington, Chris; Dale, Steinar; Faruque, MD Omar; Schoder, Karl; McLaren, Peter G.; Liu, Liming; Ravindra, Harsha; Henry, Shawn; Zhou, Yan; Liu, Xiaohu; Springstroh, Aaron; Click, David; Reedy, Robert; Moaveni, Houtan; Davis, Kristopher; Cromer, Charlie; Pappalardo, Anthoney; Krueger, Rodica; Domijan, Alexander; Islam, Arif; Islam, Mujahidil; Damole, Ademole

    2012-03-30

    This report provides details on the activities and accomplishments of Phase 1 of the Sunshine State Solar Grid Initiative (SUNGRIN) Project for the period beginning 4/28/2010 and ending 12/31/2011. SUNGRIN is a five-phase high-penetration solar PV project within the Systems Integration (SI) area of the Solar Energy Technologies (SETP) Program, under the SunShot Initiative. SUNGRIN is focused on understanding and enabling high-penetration grid-connected solar PV through simulation assisted studies of actual Florida utility high-penetration distribution circuits as well as substations and, to a limited extent, the bulk power system. Each phase builds and expands upon the efforts of the previous phase, leading to a comprehensive examination and understanding of high-penetration solar PV issues, from the solar resource to the conversion and integration technologies to the electric power system, with Florida and it’s utility partners providing the broad range of conditions and system integration scenarios necessary to develop useful insight and solutions. This phase, Phase 1, was funded with American Recovery and Reinvestment Act (ARRA) funds. This version of the final report is organized to align with statement of project objectives (SOPO) critical milestones.

  1. Integrated network design and scheduling problems :

    SciTech Connect

    Nurre, Sarah G.; Carlson, Jeffrey J.

    2014-01-01

    We consider the class of integrated network design and scheduling problems. These problems focus on selecting and scheduling operations that will change the characteristics of a network, while being speci cally concerned with the performance of the network over time. Motivating applications of INDS problems include infrastructure restoration after extreme events and building humanitarian distribution supply chains. While similar models have been proposed, no one has performed an extensive review of INDS problems from their complexity, network and scheduling characteristics, information, and solution methods. We examine INDS problems under a parallel identical machine scheduling environment where the performance of the network is evaluated by solving classic network optimization problems. We classify that all considered INDS problems as NP-Hard and propose a novel heuristic dispatching rule algorithm that selects and schedules sets of arcs based on their interactions in the network. We present computational analysis based on realistic data sets representing the infrastructures of coastal New Hanover County, North Carolina, lower Manhattan, New York, and a realistic arti cial community CLARC County. These tests demonstrate the importance of a dispatching rule to arrive at near-optimal solutions during real-time decision making activities. We extend INDS problems to incorporate release dates which represent the earliest an operation can be performed and exible release dates through the introduction of specialized machine(s) that can perform work to move the release date earlier in time. An online optimization setting is explored where the release date of a component is not known.

  2. CRI planning and scheduling for space

    NASA Technical Reports Server (NTRS)

    Aarup, Mads

    1994-01-01

    Computer Resources International (CRI) has many years of experience in developing space planning and scheduling systems for the European Space Agency. Activities range from AIT/AIV planning over mission planning to research in on-board autonomy using advanced planning and scheduling technologies in conjunction with model based diagnostics. This article presents four projects carried out for ESA by CRI with various subcontractors: (1) DI, Distributed Intelligence for Ground/Space Systems is an on-going research project; (2) GMPT, Generic Mission Planning Toolset, a feasibility study concluded in 1993; (3) OPTIMUM-AIV, Open Planning Tool for AIV, development of a knowledge based AIV planning and scheduling tool ended in 1992; and (4) PlanERS-1, development of an AI and knowledge-based mission planning prototype for the ERS-1 earth observation spacecraft ended in 1991.

  3. Automated Platform Management System Scheduling

    NASA Technical Reports Server (NTRS)

    Hull, Larry G.

    1990-01-01

    The Platform Management System was established to coordinate the operation of platform systems and instruments. The management functions are split between ground and space components. Since platforms are to be out of contact with the ground more than the manned base, the on-board functions are required to be more autonomous than those of the manned base. Under this concept, automated replanning and rescheduling, including on-board real-time schedule maintenance and schedule repair, are required to effectively and efficiently meet Space Station Freedom mission goals. In a FY88 study, we developed several promising alternatives for automated platform planning and scheduling. We recommended both a specific alternative and a phased approach to automated platform resource scheduling. Our recommended alternative was based upon use of exactly the same scheduling engine in both ground and space components of the platform management system. Our phased approach recommendation was based upon evolutionary development of the platform. In the past year, we developed platform scheduler requirements and implemented a rapid prototype of a baseline platform scheduler. Presently we are rehosting this platform scheduler rapid prototype and integrating the scheduler prototype into two Goddard Space Flight Center testbeds, as the ground scheduler in the Scheduling Concepts, Architectures, and Networks Testbed and as the on-board scheduler in the Platform Management System Testbed. Using these testbeds, we will investigate rescheduling issues, evaluate operational performance and enhance the platform scheduler prototype to demonstrate our evolutionary approach to automated platform scheduling. The work described in this paper was performed prior to Space Station Freedom rephasing, transfer of platform responsibility to Code E, and other recently discussed changes. We neither speculate on these changes nor attempt to predict the impact of the final decisions. As a consequence some of our

  4. Dose- and schedule-dependent activation and drug synergism between thymidine and 5-aza-2'-deoxycytidine in a human promyelocytic leukemia cell line.

    PubMed

    Grant, S; Rauscher, F; Margolin, J; Cadman, E

    1982-02-01

    The ability of thymidine (dThd) to enhance the metabolism and cytotoxicity of subsequent administered 5-aza-2'-deoxycytidine (5-aza-dCyd) was studied in L1210 cells and in the human promyelocytic leukemic cell line, HL-60. Exposure of L1210 cells to 0.1 mM dThd for 5 h resulted in an increase in the total intracellular and acid-precipitable accumulation of 5-aza-dCyd. Higher dThd concentrations and longer exposure intervals resulted in smaller increments in 5-aza-dCyd accumulation. In contrast, in HL-60 cells, a 24-hr exposure in 1 mM dThd resulted in the greatest intracellular accumulation of 5-aza-dCyd, 3.3 times more accumulation than in control cells. There was also a 4-fold increase in the acid-precipitable accumulation and nearly a 3-fold increase in DNA incorporation of 5-aza-dCyd in HL-60 cells exposed to the same dThd schedule. High-pressure liquid chromatographic analysis demonstrated a greater than 3-fold increase in the intracellular amounts of 5-aza-dCyd metabolites eluting in the triphosphate region in these human cells under identical conditions. Shorter dThd incubation exposure intervals (6 hr) and lower dThd concentration (0.1 mM) produced smaller increments in these studies. Both growth and clonogenic assays of HL-60 cells demonstrated a dose- and schedule sequence-dependent synergism between dThd and 5-aza-dCyd.

  5. Level II Milestone Review of LLNL Program on Grain-Scale Dynamics in Explosives

    SciTech Connect

    Nicol, M F; Benson, D J; Yip, S

    2003-01-14

    This document describes an evaluation of the Level II Milestone achievements of the LLNL program on Grain-Scale Dynamics in Explosives on January 14, 2003. ''The Grain-Scale Dynamics in Explosives Program'' is a mixture of advanced computational methodology and physico-chemical theory applied to understanding deflagration and detonation of plastic-bonded explosives from the nano to the macro scales. At many points, the modeling is tied directly to experiments within the precisions of both. Advances are needed in the experimental, theoretical, and computational aspects of detonations. Work reported in this review represents significant, cross-pollinating advances in each area. The team successfully carried out ALE-3D simulations of deflagration in PBX with grain scale effects. (Milestone requirements 1 and 2), interpreted experimental data on flame speed vs. pressure and sensitivity to global kinetics in terms of ALE-3D simulations (Milestone requirement 3), and used the results of these simulations to develop a continuum reactive flow model that captures some of these effects (Milestone requirement 4). By comparing experiments and detonation velocities in small diameter, unconfined explosives, they found non-idealities that remain at intermediate diameters (ca. 1.5 mm) that require further analysis. In all of these areas, the project team has met, indeed exceeded, their Level II Milestone goals.

  6. Expert system for on-board satellite scheduling and control

    NASA Technical Reports Server (NTRS)

    Barry, John M.; Sary, Charisse

    1988-01-01

    An Expert System is described which Rockwell Satellite and Space Electronics Division (S&SED) is developing to dynamically schedule the allocation of on-board satellite resources and activities. This expert system is the Satellite Controller. The resources to be scheduled include power, propellant and recording tape. The activities controlled include scheduling satellite functions such as sensor checkout and operation. The scheduling of these resources and activities is presently a labor intensive and time consuming ground operations task. Developing a schedule requires extensive knowledge of the system and subsystems operations, operational constraints, and satellite design and configuration. This scheduling process requires highly trained experts anywhere from several hours to several weeks to accomplish. The process is done through brute force, that is examining cryptic mnemonic data off line to interpret the health and status of the satellite. Then schedules are formulated either as the result of practical operator experience or heuristics - that is rules of thumb. Orbital operations must become more productive in the future to reduce life cycle costs and decrease dependence on ground control. This reduction is required to increase autonomy and survivability of future systems. The design of future satellites require that the scheduling function be transferred from ground to on board systems.

  7. Utilizing AI in Temporal, Spatial, and Resource Scheduling

    NASA Technical Reports Server (NTRS)

    Stottler, Richard; Kalton, Annaka; Bell, Aaron

    2006-01-01

    Aurora is a software system enabling the rapid, easy solution of complex scheduling problems involving spatial and temporal constraints among operations and scarce resources (such as equipment, workspace, and human experts). Although developed for use in the International Space Station Processing Facility, Aurora is flexible enough that it can be easily customized for application to other scheduling domains and adapted as the requirements change or become more precisely known over time. Aurora s scheduling module utilizes artificial-intelligence (AI) techniques to make scheduling decisions on the basis of domain knowledge, including knowledge of constraints and their relative importance, interdependencies among operations, and possibly frequent changes in governing schedule requirements. Unlike many other scheduling software systems, Aurora focuses on resource requirements and temporal scheduling in combination. For example, Aurora can accommodate a domain requirement to schedule two subsequent operations to locations adjacent to a shared resource. The graphical interface allows the user to quickly visualize the schedule and perform changes reflecting additional knowledge or alterations in the situation. For example, the user might drag the activity corresponding to the start of operations to reflect a late delivery.

  8. Optimal schedules of light exposure for rapidly correcting circadian misalignment.

    PubMed

    Serkh, Kirill; Forger, Daniel B

    2014-04-01

    Jet lag arises from a misalignment of circadian biological timing with the timing of human activity, and is caused by rapid transmeridian travel. Jet lag's symptoms, such as depressed cognitive alertness, also arise from work and social schedules misaligned with the timing of the circadian clock. Using experimentally validated mathematical models, we develop a new methodology to find mathematically optimal schedules of light exposure and avoidance for rapidly re-entraining the human circadian system. In simulations, our schedules are found to significantly outperform other recently proposed schedules. Moreover, our schedules appear to be significantly more robust to both noise in light and to inter-individual variations in endogenous circadian period than other proposed schedules. By comparing the optimal schedules for thousands of different situations, and by using general mathematical arguments, we are also able to translate our findings into general principles of optimal circadian re-entrainment. These principles include: 1) a class of schedules where circadian amplitude is only slightly perturbed, optimal for dim light and for small shifts 2) another class of schedules where shifting occurs along the shortest path in phase-space, optimal for bright light and for large shifts 3) the determination that short light pulses are less effective than sustained light if the goal is to re-entrain quickly, and 4) the determination that length of daytime should be significantly shorter when delaying the clock than when advancing it.

  9. Spike: Artificial intelligence scheduling for Hubble space telescope

    NASA Technical Reports Server (NTRS)

    Johnston, Mark; Miller, Glenn; Sponsler, Jeff; Vick, Shon; Jackson, Robert

    1990-01-01

    Efficient utilization of spacecraft resources is essential, but the accompanying scheduling problems are often computationally intractable and are difficult to approximate because of the presence of numerous interacting constraints. Artificial intelligence techniques were applied to the scheduling of the NASA/ESA Hubble Space Telescope (HST). This presents a particularly challenging problem since a yearlong observing program can contain some tens of thousands of exposures which are subject to a large number of scientific, operational, spacecraft, and environmental constraints. New techniques were developed for machine reasoning about scheduling constraints and goals, especially in cases where uncertainty is an important scheduling consideration and where resolving conflicts among conflicting preferences is essential. These technique were utilized in a set of workstation based scheduling tools (Spike) for HST. Graphical displays of activities, constraints, and schedules are an important feature of the system. High level scheduling strategies using both rule based and neural network approaches were developed. While the specific constraints implemented are those most relevant to HST, the framework developed is far more general and could easily handle other kinds of scheduling problems. The concept and implementation of the Spike system are described along with some experiments in adapting Spike to other spacecraft scheduling domains.

  10. Optimal Schedules of Light Exposure for Rapidly Correcting Circadian Misalignment

    PubMed Central

    Serkh, Kirill; Forger, Daniel B.

    2014-01-01

    Jet lag arises from a misalignment of circadian biological timing with the timing of human activity, and is caused by rapid transmeridian travel. Jet lag's symptoms, such as depressed cognitive alertness, also arise from work and social schedules misaligned with the timing of the circadian clock. Using experimentally validated mathematical models, we develop a new methodology to find mathematically optimal schedules of light exposure and avoidance for rapidly re-entraining the human circadian system. In simulations, our schedules are found to significantly outperform other recently proposed schedules. Moreover, our schedules appear to be significantly more robust to both noise in light and to inter-individual variations in endogenous circadian period than other proposed schedules. By comparing the optimal schedules for thousands of different situations, and by using general mathematical arguments, we are also able to translate our findings into general principles of optimal circadian re-entrainment. These principles include: 1) a class of schedules where circadian amplitude is only slightly perturbed, optimal for dim light and for small shifts 2) another class of schedules where shifting occurs along the shortest path in phase-space, optimal for bright light and for large shifts 3) the determination that short light pulses are less effective than sustained light if the goal is to re-entrain quickly, and 4) the determination that length of daytime should be significantly shorter when delaying the clock than when advancing it. PMID:24722195

  11. Remote Collaboration on Task Scheduling for Humans at Mars

    NASA Technical Reports Server (NTRS)

    Jaap, John; Meyer, Patrick; Davis, Elizabeth; Richardson, Lea

    2006-01-01

    As humans venture farther from Earth for longer durations, it will become essential for those on the journey to have significant control over the scheduling of their own activities as well as the activities of their companion systems and robots. However, the crew will not do all the scheduling; timelines will be the result of collaboration with ground personnel. Emerging technologies such as in-space message buses, delay-tolerant networks, and in-space internet will be the carriers on which the collaboration rides. Advances in scheduling technology, in the areas of task modeling, scheduling engines, and user interfaces will allow the crew to become virtual scheduling experts. New concepts of operations for producing the timeline will allow the crew and the ground support to collaborate while providing safeguards to ensure that the mission will be effectively accomplished without endangering the systems or personnel.

  12. In-Space Crew-Collaborative Task Scheduling

    NASA Technical Reports Server (NTRS)

    Jaap, John; Meyer, Patrick; Davis, Elizabeth; Richardson, Lea

    2006-01-01

    As humans venture farther from earth for longer durations, it will become essential for those on the journey to have significant control over the scheduling of their own activities as well as the activities of their companion systems and robots. However, there are many reasons why the crew will not do all the scheduling; timelines will be the result of collaboration with ground personnel. Emerging technologies such as in-space message buses, delay-tolerant networks, and in-space internet will be the carriers on which the collaboration rides. Advances in scheduling technology, in the areas of task modeling, scheduling engines, and user interfaces will allow the crew to become virtual scheduling experts. New concepts of operations for producing the timeline will allow the crew and the ground support to collaborate while providing safeguards to ensure that the mission will be effectively accomplished without endangering the systems or personnel.

  13. In-Space Crew-Collaborative Task Scheduling

    NASA Technical Reports Server (NTRS)

    Jaap, John; Meyer, Patrick; Davis, Elizabeth; Richardson, Lea

    2006-01-01

    As humans venture farther from Earth for longer durations, it will become essential for those on the journey to have significant control over the scheduling of their own activities as well as the activities of their companion systems and robots. However, the crew will not do all the scheduling; timelines will be the result of collaboration with ground personnel. Emerging technologies such as in-space message buses, delay-tolerant networks, and in-space internet will be the carriers on which the collaboration rides. Advances in scheduling technology, in the areas of task modeling, scheduling engines, and user interfaces will allow the crew to become virtual scheduling experts. New concepts of operations for producing the timeline will allow the crew and the ground support to collaborate while providing safeguards to ensure that the mission will be effectively accomplished without endangering the systems or personnel.

  14. Purple Level - 1 Milestone Review Committee I/O and Archive Follow-up Demonstration

    SciTech Connect

    Gary, M R

    2006-12-05

    On July 7th 2006, the Purple Level-1 Review Committee convened and was presented with evidence of the completion of Level-2 Milestone 461 (Deploy First Phase of I/O Infrastructure for Purple) which was performed in direct support of the Purple Level-1 milestone. This evidence included a short presentation and the formal documentation of milestone No.461 (see UCRL-TR-217288). Following the meeting, the Committee asked for the following additional evidence: (1) Set a speed measurement/goal/target assuming a number of files that the user needs to get into the archives. Then redo the benchmark using whatever tool(s) the labs prefer (HTAR, for example). Document how long the process takes. (2) Develop a test to read files back to confirm that what the user gets out of the archive is what the user put into the archive. This evidence has been collected and is presented here.

  15. Modeling kinetics and equilibrium of membranes with fields: Milestoning analysis and implication to permeation

    SciTech Connect

    Cardenas, Alfredo E.; Elber, Ron

    2014-08-07

    Coarse graining of membrane simulations by translating atomistic dynamics to densities and fields with Milestoning is discussed. The space of the membrane system is divided into cells and the different cells are characterized by order parameters presenting the number densities. The dynamics of the order parameters are probed with Milestoning. The methodology is illustrated here for a phospholipid membrane system (a hydrated bilayer of DOPC (1,2-dioleoyl-sn-glycero-3-phosphocholine) lipid molecules). Significant inhomogeneity in membrane internal number density leads to complex free energy landscape and local maps of transition times. Dynamics and distributions of cavities within the membrane assist the permeation of nonpolar solutes such as xenon atoms. It is illustrated that quantitative and detailed dynamics of water transport through DOPC membrane can be analyzed using Milestoning with fields. The reaction space for water transport includes at least two slow variables: the normal to the membrane plane, and the water density.

  16. 2007 Wholesale Power Rate Schedules : 2007 General Rate Schedule Provisions.

    SciTech Connect

    United States. Bonneville Power Administration.

    2006-11-01

    This schedule is available for the contract purchase of Firm Power to be used within the Pacific Northwest (PNW). Priority Firm (PF) Power may be purchased by public bodies, cooperatives, and Federal agencies for resale to ultimate consumers, for direct consumption, and for Construction, Test and Start-Up, and Station Service. Rates in this schedule are in effect beginning October 1, 2006, and apply to purchases under requirements Firm Power sales contracts for a three-year period. The Slice Product is only available for public bodies and cooperatives who have signed Slice contracts for the FY 2002-2011 period. Utilities participating in the Residential Exchange Program (REP) under Section 5(c) of the Northwest Power Act may purchase Priority Firm Power pursuant to the Residential Exchange Program. Rates under contracts that contain charges that escalate based on BPA's Priority Firm Power rates shall be based on the three-year rates listed in this rate schedule in addition to applicable transmission charges. This rate schedule supersedes the PF-02 rate schedule, which went into effect October 1, 2001. Sales under the PF-07 rate schedule are subject to BPA's 2007 General Rate Schedule Provisions (2007 GRSPs). Products available under this rate schedule are defined in the 2007 GRSPs. For sales under this rate schedule, bills shall be rendered and payments due pursuant to BPA's 2007 GRSPs and billing process.

  17. Schedule-induced licking during multiple schedules1

    PubMed Central

    Jacquet, Yasuko Filby

    1972-01-01

    Schedule-induced polydipsia was studied in rats bar pressing under two-component multiple schedules of food reinforcement. The first component of the multiple schedule was a variable-interval 1-min schedule throughout the experiment. The schedule comprising the second component was varied over blocks of sessions in terms of rate and magnitude of reinforcement, and was either variable-interval 3-min (one pellet), variable-interval 3-min (three pellets), variable-interval 1-min (one pellet), or extinction. Water intake per session varied with the rate of reinforcement in the schedule comprising the second component and was highest when the schedule was variable-interval 1-min. Both bar-pressing behavior and licking behavior showed behavioral interactions between the two components of the multiple schedules. With magnitude of reinforcement held constant, a matching relationship was observed between lick rate and reinforcement rate; the relative frequency of licks in the constant component matched the relative frequency of reinforcement in that component. Bar pressing, however, showed only a moderate degree of relativity matching. During the schedule-induced licking, a burst of licking followed each delivery of a pellet (post-prandial drinking). The duration of these bursts of licking was observed to be a function of the inter-reinforcement interval. PMID:16811598

  18. 1993 Wholesale Power and Transmission Rate Schedules.

    SciTech Connect

    US Bonneville Power Administration

    1993-10-01

    Bonneville Power Administration 1993 Wholesale Power Rate Schedules and General Rate Schedule Provisions and 1993 Transmission Rate Schedules and General Transmission Rate Schedule Provisions, contained herein, were approved on an interim basis effective October 1, 1993. These rate schedules and provisions were approved by the Federal Energy Commission, United States Department of Energy, in September, 1993. These rate schedules and provisions supersede the Administration`s Wholesale Power Rate Schedules and General Rate Schedule Provisions and Transmission Rate Schedules and General Transmission Rate Schedule Provisions effective October 1, 1991.

  19. DTS: Building custom, intelligent schedulers

    NASA Technical Reports Server (NTRS)

    Hansson, Othar; Mayer, Andrew

    1994-01-01

    DTS is a decision-theoretic scheduler, built on top of a flexible toolkit -- this paper focuses on how the toolkit might be reused in future NASA mission schedulers. The toolkit includes a user-customizable scheduling interface, and a 'Just-For-You' optimization engine. The customizable interface is built on two metaphors: objects and dynamic graphs. Objects help to structure problem specifications and related data, while dynamic graphs simplify the specification of graphical schedule editors (such as Gantt charts). The interface can be used with any 'back-end' scheduler, through dynamically-loaded code, interprocess communication, or a shared database. The 'Just-For-You' optimization engine includes user-specific utility functions, automatically compiled heuristic evaluations, and a postprocessing facility for enforcing scheduling policies. The optimization engine is based on BPS, the Bayesian Problem-Solver (1,2), which introduced a similar approach to solving single-agent and adversarial graph search problems.

  20. The LSST OCS scheduler design

    NASA Astrophysics Data System (ADS)

    Delgado, Francisco; Schumacher, German

    2014-08-01

    The Large Synoptic Survey Telescope (LSST) is a complex system of systems with demanding performance and operational requirements. The nature of its scientific goals requires a special Observatory Control System (OCS) and particularly a very specialized automatic Scheduler. The OCS Scheduler is an autonomous software component that drives the survey, selecting the detailed sequence of visits in real time, taking into account multiple science programs, the current external and internal conditions, and the history of observations. We have developed a SysML model for the OCS Scheduler that fits coherently in the OCS and LSST integrated model. We have also developed a prototype of the Scheduler that implements the scheduling algorithms in the simulation environment provided by the Operations Simulator, where the environment and the observatory are modeled with real weather data and detailed kinematics parameters. This paper expands on the Scheduler architecture and the proposed algorithms to achieve the survey goals.

  1. Group scheduling problems in directional sensor networks

    NASA Astrophysics Data System (ADS)

    Singh, Alok; Rossi, André

    2015-12-01

    This article addresses the problem of scheduling a set of groups of directional sensors arising as a result of applying an exact or a heuristic approach for solving a problem involving directional sensors. The problem seeks a schedule for these groups that minimizes the total energy consumed in switching from one group to the next group in the schedule. In practice, when switching from a group to the next one, active sensors in the new group have to rotate in order to face their working direction. These rotations consume energy, and the problem is to schedule the groups so as to minimize the total amount of energy consumed by all the sensor rotations, knowing the initial angular positions of all the sensors. In this article, it is assumed that energy consumption is proportional to the angular movement for all the sensors. Another problem version is also investigated that seeks to minimize the total time during which the sensor network cannot cover all the targets because active sensors are rotating. Both problems are proved to be ?-hard, and a lower bound for the first problem is presented. A greedy heuristic and a genetic algorithm are also proposed for addressing the problem of minimizing total rotation in the general case. Finally, a local search is also proposed to improve the solutions obtained through a genetic algorithm.

  2. An Analysis of Shuttle Crew Scheduling Violations

    NASA Technical Reports Server (NTRS)

    Bristol, Douglas

    2012-01-01

    From the early years of the Space Shuttle program, National Aeronautics and Space Administration (NASA) Shuttle crews have had a timeline of activities to guide them through their time on-orbit. Planners used scheduling constraints to build timelines that ensured the health and safety of the crews. If a constraint could not be met it resulted in a violation. Other agencies of the federal government also have scheduling constraints to ensure the safety of personnel and the public. This project examined the history of Space Shuttle scheduling constraints, constraints from Federal agencies and branches of the military and how these constraints may be used as a guide for future NASA and private spacecraft. This was conducted by reviewing rules and violations with regard to human aerospace scheduling constraints, environmental, political, social and technological factors, operating environment and relevant human factors. This study includes a statistical analysis of Shuttle Extra Vehicular Activity (EVA) related violations to determine if these were a significant producer of constraint violations. It was hypothesized that the number of SCSC violations caused by EVA activities were a significant contributor to the total number of violations for Shuttle/ISS missions. Data was taken from NASA data archives at the Johnson Space Center from Space Shuttle/ISS missions prior to the STS-107 accident. The results of the analysis rejected the null hypothesis and found that EVA violations were a significant contributor to the total number of violations. This analysis could help NASA and commercial space companies understand the main source of constraint violations and allow them to create constraint rules that ensure the safe operation of future human private and exploration missions. Additional studies could be performed to evaluate other variables that could have influenced the scheduling violations that were analyzed.

  3. COMPASS: An Ada based scheduler

    NASA Technical Reports Server (NTRS)

    Mcmahon, Mary Beth; Culbert, Chris

    1992-01-01

    COMPASS is a generic scheduling system developed by McDonnell Douglas and funded by the Software Technology Branch of NASA Johnson Space Center. The motivation behind COMPASS is to illustrate scheduling technology and provide a basis from which custom scheduling systems can be built. COMPASS was written in Ada to promote readability and to conform to DOD standards. COMPASS has some unique characteristics that distinguishes it from commercial products. This paper discusses these characteristics and uses them to illustrate some differences between scheduling tools.

  4. 30 CFR 285.821 - Will MMS conduct scheduled and unscheduled inspections?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 2 2011-07-01 2011-07-01 false Will MMS conduct scheduled and unscheduled... Activities Conducted Under SAPs, COPs and GAPs Inspections and Assessments § 285.821 Will MMS conduct scheduled and unscheduled inspections? The MMS will conduct both scheduled and unscheduled inspections....

  5. 15 CFR Supplement No. 1 to Part 714 - Schedule 3 Chemicals

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Schedule 3 Chemicals No. Supplement No... (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ACTIVITIES INVOLVING SCHEDULE 3 CHEMICALS Pt. 714, Supp. 1 Supplement No. 1 to Part 714—Schedule 3...

  6. 15 CFR Supplement No. 1 to Part 714 - Schedule 3 Chemicals

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 2 2011-01-01 2011-01-01 false Schedule 3 Chemicals No. Supplement No... (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ACTIVITIES INVOLVING SCHEDULE 3 CHEMICALS Pt. 714, Supp. 1 Supplement No. 1 to Part 714—Schedule 3...

  7. 15 CFR Supplement No. 1 to Part 714 - Schedule 3 Chemicals

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ACTIVITIES INVOLVING SCHEDULE 3 CHEMICALS Pt. 714, Supp. 1 Supplement No. 1 to Part 714—Schedule 3 Chemicals... 15 Commerce and Foreign Trade 2 2014-01-01 2014-01-01 false Schedule 3 Chemicals No. Supplement...

  8. 15 CFR Supplement No. 1 to Part 714 - Schedule 3 Chemicals

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ACTIVITIES INVOLVING SCHEDULE 3 CHEMICALS Pt. 714, Supp. 1 Supplement No. 1 to Part 714—Schedule 3 Chemicals... 15 Commerce and Foreign Trade 2 2013-01-01 2013-01-01 false Schedule 3 Chemicals No. Supplement...

  9. 15 CFR Supplement No. 1 to Part 714 - Schedule 3 Chemicals

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ACTIVITIES INVOLVING SCHEDULE 3 CHEMICALS Pt. 714, Supp. 1 Supplement No. 1 to Part 714—Schedule 3 Chemicals... 15 Commerce and Foreign Trade 2 2012-01-01 2012-01-01 false Schedule 3 Chemicals No. Supplement...

  10. The application of artificial intelligence to astronomical scheduling problems

    NASA Technical Reports Server (NTRS)

    Johnston, Mark D.

    1992-01-01

    Efficient utilization of expensive space- and ground-based observatories is an important goal for the astronomical community; the cost of modern observing facilities is enormous, and the available observing time is much less than the demand from astronomers around the world. The complexity and variety of scheduling constraints and goals has led several groups to investigate how artificial intelligence (AI) techniques might help solve these kinds of problems. The earliest and most successful of these projects was started at Space Telescope Science Institute in 1987 and has led to the development of the Spike scheduling system to support the scheduling of Hubble Space Telescope (HST). The aim of Spike at STScI is to allocate observations to timescales of days to a week observing all scheduling constraints and maximizing preferences that help ensure that observations are made at optimal times. Spike has been in use operationally for HST since shortly after the observatory was launched in Apr. 1990. Although developed specifically for HST scheduling, Spike was carefully designed to provide a general framework for similar (activity-based) scheduling problems. In particular, the tasks to be scheduled are defined in the system in general terms, and no assumptions about the scheduling timescale are built in. The mechanisms for describing, combining, and propagating temporal and other constraints and preferences are quite general. The success of this approach has been demonstrated by the application of Spike to the scheduling of other satellite observatories: changes to the system are required only in the specific constraints that apply, and not in the framework itself. In particular, the Spike framework is sufficiently flexible to handle both long-term and short-term scheduling, on timescales of years down to minutes or less. This talk will discuss recent progress made in scheduling search techniques, the lessons learned from early HST operations, the application of Spike

  11. Request-Driven Schedule Automation for the Deep Space Network

    NASA Technical Reports Server (NTRS)

    Johnston, Mark D.; Tran, Daniel; Arroyo, Belinda; Call, Jared; Mercado, Marisol

    2010-01-01

    The DSN Scheduling Engine (DSE) has been developed to increase the level of automated scheduling support available to users of NASA s Deep Space Network (DSN). We have adopted a request-driven approach to DSN scheduling, in contrast to the activity-oriented approach used up to now. Scheduling requests allow users to declaratively specify patterns and conditions on their DSN service allocations, including timing, resource requirements, gaps, overlaps, time linkages among services, repetition, priorities, and a wide range of additional factors and preferences. The DSE incorporates a model of the key constraints and preferences of the DSN scheduling domain, along with algorithms to expand scheduling requests into valid resource allocations, to resolve schedule conflicts, and to repair unsatisfied requests. We use time-bounded systematic search with constraint relaxation to return nearby solutions if exact ones cannot be found, where the relaxation options and order are under user control. To explore the usability aspects of our approach we have developed a graphical user interface incorporating some crucial features to make it easier to work with complex scheduling requests. Among these are: progressive revelation of relevant detail, immediate propagation and visual feedback from a user s decisions, and a meeting calendar metaphor for repeated patterns of requests. Even as a prototype, the DSE has been deployed and adopted as the initial step in building the operational DSN schedule, thus representing an important initial validation of our overall approach. The DSE is a core element of the DSN Service Scheduling Software (S(sup 3)), a web-based collaborative scheduling system now under development for deployment to all DSN users.

  12. Chemical Kiloton Experiment schedules

    NASA Astrophysics Data System (ADS)

    The Lawrence Livermore National Laboratory will conduct a large chemical explosion (CE) called the Chemical Kiloton Experiment (CKE) in the Rainier Mesa area of the Nevada Test site. The explosion will involve a 30/70 Emulsion-to-ANFO blend of 1,147,000 kg to supply 1 kt, and is scheduled for January 29. It will be heavily instrumented with close-in, free-field surface seismic and regional seismic measurements. The CKE is located near several DNA-sponsored nuclear explosions (NEs) and will provide a unique opportunity for fundamental studies on explosion phenomenology (for example, CE/NE equivalence), scaling with CEs and NEs, and integration of multiple monitoring methods. This experiment will also address some critical proliferation monitoring problems such as CE masking of NEs, CEs as false alarms, CEs for regional calibration, and on-site inspection.

  13. Optimum connection management scheduling

    NASA Astrophysics Data System (ADS)

    Kadar, Ivan

    2000-08-01

    Connection Management plays a key role in both distributed 'local' network-centric and 'globally' connected info- centric systems. The role of Connection Management is to provide seamless demand-based sharing of the information products. For optimum distributed information fusion performance, these systems must minimize communications delays and maximize message throughput, and at the same time take into account relative-sensors-targets geometrical constraints and data pedigree. In order to achieve overall distributed 'network' effectiveness, these systems must be adaptive, and be able to distribute data s needed in real- time. A system concept will be described which provides optimum capacity-based information scheduling. A specific example, based on a satellite channel, is used to illustrate simulated performance results and their effects on fusion systems performance.

  14. Visually Exploring Transportation Schedules.

    PubMed

    Palomo, Cesar; Guo, Zhan; Silva, Cláudio T; Freire, Juliana

    2016-01-01

    Public transportation schedules are designed by agencies to optimize service quality under multiple constraints. However, real service usually deviates from the plan. Therefore, transportation analysts need to identify, compare and explain both eventual and systemic performance issues that must be addressed so that better timetables can be created. The purely statistical tools commonly used by analysts pose many difficulties due to the large number of attributes at trip- and station-level for planned and real service. Also challenging is the need for models at multiple scales to search for patterns at different times and stations, since analysts do not know exactly where or when relevant patterns might emerge and need to compute statistical summaries for multiple attributes at different granularities. To aid in this analysis, we worked in close collaboration with a transportation expert to design TR-EX, a visual exploration tool developed to identify, inspect and compare spatio-temporal patterns for planned and real transportation service. TR-EX combines two new visual encodings inspired by Marey's Train Schedule: Trips Explorer for trip-level analysis of frequency, deviation and speed; and Stops Explorer for station-level study of delay, wait time, reliability and performance deficiencies such as bunching. To tackle overplotting and to provide a robust representation for a large numbers of trips and stops at multiple scales, the system supports variable kernel bandwidths to achieve the level of detail required by users for different tasks. We justify our design decisions based on specific analysis needs of transportation analysts. We provide anecdotal evidence of the efficacy of TR-EX through a series of case studies that explore NYC subway service, which illustrate how TR-EX can be used to confirm hypotheses and derive new insights through visual exploration.

  15. 20 CFR 411.545 - How are the outcome payments calculated under the outcome-milestone payment system?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... the outcome-milestone payment system? 411.545 Section 411.545 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM Employment Network Payment Systems § 411.545 How... Title XVI amount of payment Phase 1 (120% of Title II PCB) Milestone 1 $335/mo. $670/mo. × 3 mo. work...

  16. From Kissing to Coitus? Sex-of-Partner Differences in the Sexual Milestone Achievement of Young Men

    ERIC Educational Resources Information Center

    Smiler, Andrew P.; Frankel, Loren B. W.; Savin-Williams, Ritch C.

    2011-01-01

    Scientific information regarding normative patterns of young men's sexual behavior is insufficient, especially regarding the impact of sex of partner. We explored the age at which 255 young adult men achieved several milestones (e.g., first kiss, manual-genital contact, intercourse) as well as the sequence of milestone achievement and stability in…

  17. Tug fleet and ground operations schedules and controls. Volume 2: part 1

    NASA Technical Reports Server (NTRS)

    1975-01-01

    This Tug Fleet and Ground Operations Schedules and Controls Study addresses both ground operational data and technical requirements that span the Tug planning phase and operations phase. A similar study covering mission operations (by others) provides the complimentary flight operations details. The two studies provide the planning data requirements, resource allocation, and control milestones for supporting the requirements of the STS program. This Tug Fleet and Ground Operations Schedules and Controls Study incorporates the basic ground operations requirements and concepts provided by previous studies with the interrelationships of the planning, IUS transition, and Tug fleet operations phases. The interrelationships of these phases were studied as a system to optimize overall program benefits and minimize operational risk factors.

  18. Milestones in plant sulfur research on sulfur-induced-resistance (SIR) in Europe.

    PubMed

    Bloem, Elke; Haneklaus, Silvia; Schnug, Ewald

    2014-01-01

    Until the 1970's of the last century sulfur (S) was mainly regarded as a pollutant being the main contributor of acid rain, causing forest dieback in central Europe. When Clean Air Acts came into force at the start of the 1980's SO2 contaminations in the air were consequently reduced within the next years. S changed from an unwanted pollutant into a lacking plant nutrient in agriculture since agricultural fields were no longer "fertilized" indirectly by industrial pollution. S deficiency was first noticed in Brassica crops that display an especially high S demand because of its content of S-containing secondary metabolites, the glucosinolates. In Scotland, where S depositions decreased even faster than in continental Europe, an increasing disease incidence with Pyrenopeziza brassicae was observed in oilseed rape in the beginning 1990's and the concept of sulfur-induced-resistance (SIR) was developed after a relationship between the S status and the disease incidence was uncovered. Since then a lot of research was carried out to unravel the background of SIR in the metabolism of agricultural crops and to identify metabolites, enzymes and reactions, which are potentially activated by the S metabolism to combat fungal pathogens. The S status of the crop is affecting many different plant features such as color and scent of flowers, pigments in leaves, metabolite concentrations and the release of gaseous S compounds which are directly influencing the desirability of a crop for a variety of different organisms from microorganisms, over insects and slugs to the point of grazing animals. The present paper is an attempt to sum up the knowledge about the effect of the S nutritional status of agricultural crops on parameters that are directly related to their health status and by this to SIR. Milestones in SIR research are compiled, open questions are addressed and future projections were developed. PMID:25642233

  19. Milestones in plant sulfur research on sulfur-induced-resistance (SIR) in Europe.

    PubMed

    Bloem, Elke; Haneklaus, Silvia; Schnug, Ewald

    2014-01-01

    Until the 1970's of the last century sulfur (S) was mainly regarded as a pollutant being the main contributor of acid rain, causing forest dieback in central Europe. When Clean Air Acts came into force at the start of the 1980's SO2 contaminations in the air were consequently reduced within the next years. S changed from an unwanted pollutant into a lacking plant nutrient in agriculture since agricultural fields were no longer "fertilized" indirectly by industrial pollution. S deficiency was first noticed in Brassica crops that display an especially high S demand because of its content of S-containing secondary metabolites, the glucosinolates. In Scotland, where S depositions decreased even faster than in continental Europe, an increasing disease incidence with Pyrenopeziza brassicae was observed in oilseed rape in the beginning 1990's and the concept of sulfur-induced-resistance (SIR) was developed after a relationship between the S status and the disease incidence was uncovered. Since then a lot of research was carried out to unravel the background of SIR in the metabolism of agricultural crops and to identify metabolites, enzymes and reactions, which are potentially activated by the S metabolism to combat fungal pathogens. The S status of the crop is affecting many different plant features such as color and scent of flowers, pigments in leaves, metabolite concentrations and the release of gaseous S compounds which are directly influencing the desirability of a crop for a variety of different organisms from microorganisms, over insects and slugs to the point of grazing animals. The present paper is an attempt to sum up the knowledge about the effect of the S nutritional status of agricultural crops on parameters that are directly related to their health status and by this to SIR. Milestones in SIR research are compiled, open questions are addressed and future projections were developed.

  20. Scheduling constrained tools using heuristic techniques

    NASA Astrophysics Data System (ADS)

    Maram, Venkataramana; Rahman, Syariza Abdul; Maram, Sandhya Rani

    2015-12-01

    One of the main challenge to the current manufacturing production planning is to provide schedules of operations to maximize resource utilization to yield highest overall productivity. This is achieved by scheduling available resources to activities. There can be many different real time scenarios with different combination of input resources to produce parts. In this paper, the problem is simplified to single machine with individual process times and due dates to represent the real world scheduling problem. The main objective function is to minimize the total tardiness or late jobs. Nearest greedy method of assignment problem algorithm is used to find the initial solution followed by Simulated Annealing (SA) algorithm for the improvement part. Simulated Annealing is one of the meta-heuristic techniques in solving combinatorial optimization problem. The general purpose Microsoft Visual C++ is used to developed algorithm for finding the best solution. The proposed hybrid approach able to generate best schedule in 7th and optimal in 170th iteration with tardiness 8 and 7 hours respectively.

  1. Incremental Scheduling Engines for Human Exploration of the Cosmos

    NASA Technical Reports Server (NTRS)

    Jaap, John; Phillips, Shaun

    2005-01-01

    As humankind embarks on longer space missions farther from home, the requirements and environments for scheduling the activities performed on these missions are changing. As we begin to prepare for these missions it is appropriate to evaluate the merits and applicability of the different types of scheduling engines. Scheduling engines temporally arrange tasks onto a timeline so that all constraints and objectives are met and resources are not overbooked. Scheduling engines used to schedule space missions fall into three general categories: batch, mixed-initiative, and incremental. This paper presents an assessment of the engine types, a discussion of the impact of human exploration of the moon and Mars on planning and scheduling, and the applicability of the different types of scheduling engines. This paper will pursue the hypothesis that incremental scheduling engines may have a place in the new environment; they have the potential to reduce cost, to improve the satisfaction of those who execute or benefit from a particular timeline (the customers), and to allow astronauts to plan their own tasks and those of their companion robots.

  2. Milestones in the Secondary English Curriculum in the United States. ICTE Occasional Paper No. 11.

    ERIC Educational Resources Information Center

    Bleakley, Lou Ann

    Written for students pursuing graduate study, this chronological table lists landmark publications in the secondary English curriculum occurring between 1893 and 1971. For each of the 27 milestones--e.g., "Report of the Committee of Ten on Secondary School Studies" (1893), "Teaching Creative Writing" by Lawrence Conrad (1937), "The Uses of…

  3. 20 CFR 411.540 - How are the payment amounts calculated for each of the milestones?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false How are the payment amounts calculated for each of the milestones? 411.540 Section 411.540 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM Employment Network Payment Systems § 411.540 How are...

  4. 20 CFR 411.540 - How are the payment amounts calculated for each of the milestones?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false How are the payment amounts calculated for each of the milestones? 411.540 Section 411.540 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM Employment Network Payment Systems § 411.540 How are...

  5. "Educate, Don't Segregate": Twenty Legal and Legislative Milestones in Higher Education

    ERIC Educational Resources Information Center

    Black Issues in Higher Education, 2004

    2004-01-01

    This timeline reflects some of the most significant legal and legislative milestones that have influenced higher education almost as long as Black Issues In Higher Education has been in print. The ongoing legal battles have primarily involved the further desegregation of schools and the use of race and gender in scholarships and university…

  6. 20 CFR 411.535 - Under what circumstances will milestones be paid?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... paid? 411.535 Section 411.535 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND... earnings were less than the trial work level in each of the 18 months before the ticket was first assigned to an EN. All work and earnings counted toward reaching the four Phase 1 milestones must occur...

  7. 20 CFR 411.535 - Under what circumstances will milestones be paid?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... paid? 411.535 Section 411.535 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND... earnings were less than the trial work level in each of the 18 months before the ticket was first assigned to an EN. All work and earnings counted toward reaching the four Phase 1 milestones must occur...

  8. 20 CFR 411.535 - Under what circumstances will milestones be paid?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... paid? 411.535 Section 411.535 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND... earnings were less than the trial work level in each of the 18 months before the ticket was first assigned to an EN. All work and earnings counted toward reaching the four Phase 1 milestones must occur...

  9. 20 CFR 411.540 - How are the payment amounts calculated for each of the milestones?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false How are the payment amounts calculated for each of the milestones? 411.540 Section 411.540 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM Employment Network Payment Systems § 411.540 How are...

  10. Sexual Orientation Identity Formation among Gay, Lesbian, and Bisexual Youths: Multiple Patterns of Milestone Experiences.

    ERIC Educational Resources Information Center

    Floyd, Frank J.; Stein, Terry S.

    2002-01-01

    Examined variations in "coming out" for gay, lesbian, and bisexual youths, specifically: the timing and sequence of developmental stages; completion of 10 milestone events involving self-awareness, sexual experiences, and disclosure to others; and immersion in social networks. Found comfort with sexual orientation was greatest in persons with…

  11. Analyzing Milestones in Smoking Cessation: Illustration in a Nicotine Patch Trial in Adult Smokers

    ERIC Educational Resources Information Center

    Shiffman, Saul; Scharf, Deborah M.; Shadel, William G.; Gwaltney, Chad J.; Dang, Qianyu; Paton, Stephanie M.; Clark, Duncan B.

    2006-01-01

    Tests of addiction treatments seldom reveal where treatment exercises its effect (i.e., promoting initial abstinence, preventing lapses, and/or impeding progression from lapse to relapse). The authors illustrate analyses distinguishing effects on these milestones in a randomized trial of high-dose nicotine patch (35 mg; n = 188) versus placebo (n…

  12. Relations of Alcohol Consumption with Smoking Cessation Milestones and Tobacco Dependence

    ERIC Educational Resources Information Center

    Cook, Jessica W.; Fucito, Lisa M.; Piasecki, Thomas M.; Piper, Megan E.; Schlam, Tanya R.; Berg, Kristin M.; Baker, Timothy B.

    2012-01-01

    Objective: Alcohol consumption is associated with smoking cessation failure in both community and clinical research. However, little is known about the relation between alcohol consumption and smoking cessation milestones (i.e., achieving initial abstinence, avoiding lapses and relapse). Our objective in this research was to examine the relations…

  13. From Early to Current Developments in Online Learning at Nova Southeastern University: Reflections on Historical Milestones.

    ERIC Educational Resources Information Center

    Dringus, Laurie P.; Scigliano, John A.

    2000-01-01

    Traces the major historical milestones achieved by Nova Southeastern University in its pioneering of graduate level online learning programs. Highlights include delivery systems; Web-based electronic classrooms; overview of the technology, including telecommunications through UNIX; evaluation and research; and technology used in the School of…

  14. Effects of Family and Friend Support on LGB Youths' Mental Health and Sexual Orientation Milestones

    ERIC Educational Resources Information Center

    Shilo, Guy; Savaya, Riki

    2011-01-01

    This study examined the effects of social support components and providers on mental health and sexual orientation (SO) milestones of lesbian, gay, and bisexual (LGB) youths. Data were collected on 461 self-identified LGB adolescents and young adults. Family acceptance and support yielded the strongest positive effect on self-acceptance of SO,…

  15. Puberty: Maturation, Timing and Adjustment, and Sexual Identity Developmental Milestones among Lesbian, Gay, and Bisexual Youth

    ERIC Educational Resources Information Center

    Grossman, Arnold H.; Foss, Alexander H.; D'Augelli, Anthony R.

    2014-01-01

    This study examined pubertal maturation, pubertal timing and outcomes, and the relationship of puberty and sexual identity developmental milestones among 507 lesbian, gay, and bisexual youth. The onset of menarche and spermarche occurred at the mean ages of 12.05 and 12.46, respectively. There was no statistically significant difference in…

  16. Outcomes and milestone achievement differences for very low-birth-weight multiples compared with singleton infants.

    PubMed

    Kirkby, Sharon; Genen, Linda; Turenne, Wendy; Dysart, Kevin

    2010-06-01

    We examined if very low-birth-weight (VLBW) infants of multiple gestation pregnancies experience more complications and take longer to achieve clinical milestones compared with similar singletons. We performed a retrospective analysis of all infants less than 1500 g at birth in a large neonatal database. Singletons were compared with twins and higher-order multiples for demographic, morbidities, and process milestones including feeding, respiratory, thermoregulation, and length of stay. Multivariable regression analyses were performed to control for potential confounding variables. A total of 5507 infants were included: 3792 singletons, 1391 twins, and 324 higher-order multiples. There were no differences in Apgar scores, small for gestational age status, and incidence of necrotizing enterocolitis, severe retinopathy of prematurity, severe intraventricular hemorrhage, sepsis, bronchopulmonary dysplasia, or the need for surgery. Multiples had higher rates of apnea and patent ductus arteriosus than singletons. VLBW multiples achieved milestones at similar rates in most areas compared with singletons except for the achievement of full oral feedings. Length of stay, after controlling for confounding variables, did not differ between the groups. Compared with singletons, VLBW multiples had similar morbidity and achieved most feeding and thermoregulation milestones at similar rates.

  17. Providing lipid-based nutrient supplements does not affect developmental milestones among Malawian children

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Our objective was to assess whether using lipid-based nutrient supplements (LNS) to complement the diets of infants and young children affected when they achieved selected developmental milestones. In rural Malawi, 840 6-month-old healthy infants were enrolled to a randomised trial. Control particip...

  18. Vouchers in Hong Kong: A New Milestone of Early Childhood Education?

    ERIC Educational Resources Information Center

    Yuen, Gail W. K.

    2007-01-01

    The Hong Kong government has recently introduced a voucher system to early childhood education, indicating that the new policy is a milestone in the field. The overall goal of the policy is to improve the provision of early childhood education for the benefit of the children. Public debates reveal the unfamiliar nature of the subject to the local…

  19. Motor Milestone Development in Young Children with Autism Spectrum Disorders: An Exploratory Study

    ERIC Educational Resources Information Center

    Liu, Ting

    2012-01-01

    This study aimed to determine if a sample of children currently diagnosed with autism spectrum disorders (ASDs) would have shown motor milestone delays before age three as compared to typically developing children. Given delays in motor skills, the study also strived to determine which specific skills might be delayed. Parents of 44 children who…

  20. 32 CFR 37.575 - What are my responsibilities for determining milestone payment amounts?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false What are my responsibilities for determining milestone payment amounts? 37.575 Section 37.575 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Pre-Award...

  1. Modeling the Cray memory scheduler

    SciTech Connect

    Wickham, K.L.; Litteer, G.L.

    1992-04-01

    This report documents the results of a project to evaluate low cost modeling and simulation tools when applied to modeling the Cray memory scheduler. The specific tool used is described and the basics of the memory scheduler are covered. Results of simulations using the model are discussed and a favorable recommendation is made to make more use of this inexpensive technology.

  2. Block Schedule: Breaking the Barriers.

    ERIC Educational Resources Information Center

    West, Mike

    As of 1996, Chaparral High School in Las Vegas, Nevada, was in the fourth year of a radical restructuring effort. The school changed from a 6-period day, composed of 51-minute periods, to an alternating day schedule, composed of 3 102-minute periods per day. This report describes how the school developed and implemented the new schedule. Faculty…

  3. Flexible Work Schedules. ERIC Digest.

    ERIC Educational Resources Information Center

    Kerka, Sandra

    Flexible work schedules are one response to changes in the composition of the work force, new life-styles, and changes in work attitudes. Types of alternative work schedules are part-time and temporary employment, job sharing, and flextime. Part-time workers are a diverse group--women, the very young, and older near-retirees. Although part-time…

  4. Concurrent schedules: Quantifying the aversiveness of noise

    PubMed Central

    McAdie, Tina M.; Foster, T. Mary; Temple, William

    1996-01-01

    Four hens worked under independent multiple concurrent variable-interval schedules with an overlaid aversive stimulus (sound of hens in a poultry shed at 100dBA) activated by the first peck on a key. The sound remained on until a response was made on the other key. The key that activated the sound in each component was varied over a series of conditions. When the sound was activated by the left (or right) key in one component, it was activated by the right (or left) key in the other component. Bias was examined under a range of different variable-interval schedules, and the applicability of the generalized matching law was examined. It was found that the hens' behavior was biased away from the sound independently of the schedule in effect and that this bias could be quantified using a modified version of the generalized matching law. Behavior during the changeover delays was not affected by the presence of the noise or by changes in reinforcement rate, even though the total response measures were. Insensitivity shown during the delay suggests that behavior after the changeover delay may be more appropriate as a measure of preference (or aversiveness) of stimuli than are overall behavior measures. PMID:16812802

  5. Scheduling with partial orders and a causal model

    NASA Technical Reports Server (NTRS)

    Boddy, Mark; Carciofini, Jim; Hadden, George D.

    1993-01-01

    In an ongoing project at Honeywell SRC, we are constructing a prototype scheduling system for a NASA domain using the 'Time Map Manager' (TMM). The TMM representations are flexible enough to permit the representation of precedence constraints, metric constraints between activities, and constraints relative to a variety of references (e.g., Mission Elapsed Time vs. Mission Day). The TMM also supports a simple form of causal reasoning (projection), dynamic database updates, and monitoring specified database properties as changes occur over time. The greatest apparent advantage to using the TMM is the flexibility added to the scheduling process: schedules are constructed by a process of 'iterative refinement,' in which scheduling decisions correspond to constraining an activity either with respect to another activity or with respect to one time line. The schedule becomes more detailed as activities and constraints are added. Undoing a scheduling decision means removing a constraint, not removing an activity from a specified place on the time line. For example, we can move an activity around on the time line by deleting constraints and adding new ones.

  6. Schedules of Controlled Substances: Temporary Placement of the Synthetic Cannabinoid MAB-CHMINACA Into Schedule I. Final order.

    PubMed

    2016-02-01

    The Administrator of the Drug Enforcement Administration is issuing this final order to temporarily schedule the synthetic cannabinoid N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-(cyclohexylmethyl)-1H-indazole-3-carboxamide (common names, MAB-CHMINACA and ADB-CHMINACA), and its optical, positional, and geometric isomers, salts, and salts of isomers into schedule I pursuant to the temporary scheduling provisions of the Controlled Substances Act. This action is based on a finding by the Administrator that the placement of this synthetic cannabinoid into schedule I of the Controlled Substances Act is necessary to avoid an imminent hazard to the public safety. As a result of this order, the regulatory controls and administrative, civil, and criminal sanctions applicable to schedule I controlled substances will be imposed on persons who handle (manufacture, distribute, reverse distribute, import, export, engage in research, conduct instructional activities or chemical analysis, or possess), or propose to handle, MAB-CHMINACA. PMID:26859902

  7. Scheduling Software for MS-DOS Microcomputers.

    ERIC Educational Resources Information Center

    Carlson, David H.; Prior, Barbara

    1991-01-01

    Identifies four microcomputer-based software packages for scheduling and evaluates their usefulness for scheduling employees in a library setting. Evaluation criteria are applied to (1) Schedule Master, from Schedule Master Corporation; (2) Schedule Plus, from Cyclesoft, Inc.; (3) Who Works When, from Newport Systems; and (4) Working Hours, from…

  8. Solve Your Scheduling Puzzle without a Computer.

    ERIC Educational Resources Information Center

    Toy, Steve

    1982-01-01

    The small Lone Star school district in Otis (Colorado) developed a year-long process for creating its master course schedule. The scheduling process includes a needs assessment, a curriculum scheduling committee of teachers and students, a trial run of the schedule, and board approval of the master schedule. (RW)

  9. Knowledge based tools for Hubble Space Telescope planning and scheduling: Constraints and strategies

    NASA Technical Reports Server (NTRS)

    Miller, Glenn; Johnston, Mark; Vick, Shon; Sponsler, Jeff; Lindenmayer, Kelly

    1988-01-01

    The Hubble Space Telescope (HST) presents an especially challenging scheduling problem since a year's observing program encompasses tens of thousands of exposures facing numerous coupled constraints. Recent progress in the development of planning and scheduling tools is discussed which augment the existing HST ground system. General methods for representing activities, constraints, and constraint satisfaction, and time segmentation were implemented in a scheduling testbed. The testbed permits planners to evaluate optimal scheduling time intervals, calculate resource usage, and to generate long and medium range plans. Graphical displays of activities, constraints, and plans are an important feature of the system. High-level scheduling strategies using rule based and neural net approaches were implemented.

  10. Astronaut Office Scheduling System Software

    NASA Technical Reports Server (NTRS)

    Brown, Estevancio

    2010-01-01

    AOSS is a highly efficient scheduling application that uses various tools to schedule astronauts weekly appointment information. This program represents an integration of many technologies into a single application to facilitate schedule sharing and management. It is a Windows-based application developed in Visual Basic. Because the NASA standard office automation load environment is Microsoft-based, Visual Basic provides AO SS developers with the ability to interact with Windows collaboration components by accessing objects models from applications like Outlook and Excel. This also gives developers the ability to create newly customizable components that perform specialized tasks pertaining to scheduling reporting inside the application. With this capability, AOSS can perform various asynchronous tasks, such as gathering/ sending/ managing astronauts schedule information directly to their Outlook calendars at any time.

  11. The GBT Dynamic Scheduling System: A New Scheduling Paradigm

    NASA Astrophysics Data System (ADS)

    O'Neil, K.; Balser, D.; Bignell, C.; Clark, M.; Condon, J.; McCarty, M.; Marganian, P.; Shelton, A.; Braatz, J.; Harnett, J.; Maddalena, R.; Mello, M.; Sessoms, E.

    2009-09-01

    The Robert C. Byrd Green Bank Telescope (GBT) is implementing a new Dynamic Scheduling System (DSS) designed to maximize the observing efficiency of the telescope while ensuring that none of the flexibility and ease of use of the GBT is harmed and that the data quality of observations is not adversely affected. To accomplish this, the GBT DSS is implementing a dynamic scheduling system which schedules observers, rather than running scripts. The DSS works by breaking each project into one or more sessions which have associated observing criteria such as RA, Dec, and frequency. Potential observers may also enter dates when members of their team will not be available for either on-site or remote observing. The scheduling algorithm uses those data, along with the predicted weather, to determine the most efficient schedule for the GBT. The DSS provides all observers at least 24 hours notice of their upcoming observing. In the uncommon (< 20%) case where the actual weather does not match the predictions, a backup project, chosen from the database, is run instead. Here we give an overview of the GBT DSS project, including the ranking and scheduling algorithms for the sessions, the scheduling probabilities generation, the web framework for the system, and an overview of the results from the beta testing which were held from June - September, 2008.

  12. Emergency Medicine Residents Consistently Rate Themselves Higher than Attending Assessments on ACGME Milestones

    PubMed Central

    Goldflam, Katja; Bod, Jessica; Della-Giustina, David; Tsyrulnik, Alina

    2015-01-01

    Introduction In 2012 the Accreditation Council for Graduate Medical Education (ACGME) introduced the Next Accreditation System (NAS), which implemented milestones to assess the competency of residents and fellows. While attending evaluation and feedback is crucial for resident development, perhaps equally important is a resident’s self-assessment. If a resident does not accurately self-assess, clinical and professional progress may be compromised. The objective of our study was to compare emergency medicine (EM) resident milestone evaluation by EM faculty with the same resident’s self-assessment. Methods This is an observational, cross-sectional study that was performed at an academic, four-year EM residency program. Twenty-five randomly chosen residents completed milestone self-assessment using eight ACGME sub-competencies deemed by residency leadership as representative of core EM principles. These residents were also evaluated by 20 faculty members. The milestone levels were evaluated on a nine-point scale. We calculated the average difference between resident self-ratings and faculty ratings, and used sample t-tests to determine statistical significance of the difference in scores. Results Eighteen residents evaluated themselves. Each resident was assessed by an average of 16 attendings (min=10, max=20). Residents gave themselves statistically significant higher milestone ratings than attendings did for each sub-competency examined (p<0.0001). Conclusion Residents over-estimated their abilities in every sub-competency assessed. This underscores the importance of feedback and assessment transparency. More attention needs to be paid to methods by which residency leadership can make residents’ self-perception of their clinical ability more congruent with that of their teachers and evaluators. The major limitation of our study is small sample size of both residents and attendings. PMID:26594293

  13. Schedules of controlled substances: temporary placement of four synthetic cannabinoids into Schedule I. Final order.

    PubMed

    2014-02-10

    The Deputy Administrator of the Drug Enforcement Administration (DEA) is issuing this final order to temporarily schedule four synthetic cannabinoids into schedule I pursuant to the temporary scheduling provisions of the Controlled Substances Act (CSA). The substances are: Quinolin-8-yl 1-pentyl-1H-indole-3-carboxylate (PB-22; QUPIC); quinolin-8-yl 1-(5-fluoropentyl)-1H-indole-3-carboxylate (5-fluoro-PB-22; 5F-PB-22); N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indazole-3-carboxamide (AB-FUBINACA); and N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-pentyl-1H-indazole-3-carboxamide (ADB-PINACA). This action is based on a finding by the Deputy Administrator that the placement of these synthetic cannabinoids and their optical, positional, and geometric isomers, salts and salts of isomers into schedule I of the CSA is necessary to avoid an imminent hazard to the public safety. As a result of this order, the regulatory controls and administrative, civil, and criminal sanctions applicable to schedule I controlled substances will be imposed on persons who handle (manufacture, distribute, import, export, engage in research, conduct instructional activities, and possess), or propose to handle these synthetic cannabinoids. PMID:24605391

  14. Schedules of Controlled Substances: Placement of AH-7921 Into Schedule I. Final order.

    PubMed

    2016-04-14

    With the issuance of this final order, the Administrator of the Drug Enforcement Administration places the substance AH-7921 (Systematic IUPAC Name: 3,4-dichloro-N-[(1dimethylamino)cyclohexylmethyl]benzamide), including its isomers, esters, ethers, salts, and salts of isomers, esters and ethers, into schedule I of the Controlled Substances Act. This scheduling action is pursuant to the Controlled Substances Act and is required in order for the United States to discharge its obligations under the Single Convention on Narcotic Drugs, 1961. This action imposes the regulatory controls and administrative, civil, and criminal sanctions applicable to schedule I controlled substances on persons who handle (manufacture, distribute, import, export, engage in research or conduct instructional activities with, or possess), or propose to handle, AH-7921. PMID:27101639

  15. Phase II-I-II Study of Two Different Doses and Schedules of Pralatrexate, a High-Affinity Substrate for the Reduced Folate Carrier, in Patients With Relapsed or Refractory Lymphoma Reveals Marked Activity in T-Cell Malignancies

    PubMed Central

    O'Connor, Owen A.; Horwitz, Steven; Hamlin, Paul; Portlock, Carol; Moskowitz, Craig H.; Sarasohn, Debra; Neylon, Ellen; Mastrella, Jill; Hamelers, Rachel; MacGregor-Cortelli, Barbara; Patterson, Molly; Seshan, Venkatraman E.; Sirotnak, Frank; Fleisher, Martin; Mould, Diane R.; Saunders, Mike; Zelenetz, Andrew D.

    2009-01-01

    Purpose To determine the maximum-tolerated dose (MTD) and efficacy of pralatrexate in patients with lymphoma. Patients and Methods Pralatrexate, initially given at a dose of 135 mg/m2 on an every-other-week basis, was associated with stomatitis. A redesigned, weekly phase I/II study established an MTD of 30 mg/m2 weekly for six weeks every 7 weeks. Patients were required to have relapsed/refractory disease, an absolute neutrophil greater than 1,000/μL, and a platelet count greater than 50,000/μL for the first dose of any cycle. Results The every-other-week, phase II experience was associated with an increased risk of stomatitis and hematologic toxicity. On a weekly schedule, the MTD was 30 mg/m2 weekly for 6 weeks every 7 weeks. This schedule modification resulted in a 50% reduction in the major hematologic toxicities and abrogation of the grades 3 to 4 stomatitis. Stomatitis was associated with elevated homocysteine and methylmalonic acid, which were reduced by folate and vitamin B12 supplementation. Of 48 assessable patients, the overall response rate was 31% (26% by intention to treat), including 17% who experienced complete remission (CR). When analyzed by lineage, the overall response rates were 10% and 54% in patients with B- and T-cell lymphomas, respectively. All eight patients who experienced CR had T-cell lymphoma, and four of the six patients with a partial remission were positron emission tomography negative. The duration of responses ranged from 3 to 26 months. Conclusion Pralatrexate has significant single-agent activity in patients with relapsed/refractory T-cell lymphoma. PMID:19652067

  16. Immunization Schedules for Infants and Children

    MedlinePlus

    ... ACIP Vaccination Recommendations Why Immunize? Vaccines: The Basics Immunization Schedules for Infants and Children Recommend on Facebook ... any questions. View or Print a Schedule Recommended Immunizations for Children (Birth through 6 years) Schedule for ...

  17. Developing an Experiential Learning Program: Milestones and Challenges

    ERIC Educational Resources Information Center

    Austin, M. Jill; Rust, Dianna Zeh

    2015-01-01

    College and University faculty members have increasingly adopted experiential learning teaching methods that are designed to engage students in the learning process. Experiential learning is simply defined as "hands-on" learning and may involve any of the following activities: service learning, applied learning in the discipline,…

  18. Expert systems tools for Hubble Space Telescope observation scheduling

    NASA Technical Reports Server (NTRS)

    Miller, Glenn; Rosenthal, Don; Cohen, William; Johnston, Mark

    1987-01-01

    The utility of expert systems techniques for the Hubble Space Telescope (HST) planning and scheduling is discussed and a plan for development of expert system tools which will augment the existing ground system is described. Additional capabilities provided by these tools will include graphics-oriented plan evaluation, long-range analysis of the observation pool, analysis of optimal scheduling time intervals, constructing sequences of spacecraft activities which minimize operational overhead, and optimization of linkages between observations. Initial prototyping of a scheduler used the Automated Reasoning Tool running on a LISP workstation.

  19. Show me the money: the implications of Schedule H.

    PubMed

    Salinsky, Eileen

    2009-04-21

    Responding to policymakers' concerns, the Internal Revenue Service (IRS) implemented significant new hospital community benefit reporting under Schedule H of its revised Form 990, the return used by tax-exempt organizations. This issue brief considers the policy implications of the quantitative and qualitative information that hospitals are now mandated to report through Schedule H, including the costs associated with charity care, bad debt, and the unreimbursed costs of Medicaid and Medicare. The paper examines unresolved issues related to the new reporting requirements, such as controversies regarding the scope of Schedule H, and considers the potential for these reports to influence IRS oversight activities, legislative action, and hospital policies and practices.

  20. Gang scheduling a parallel machine

    SciTech Connect

    Gorda, B.C.; Brooks, E.D. III.

    1991-03-01

    Program development on parallel machines can be a nightmare of scheduling headaches. We have developed a portable time sharing mechanism to handle the problem of scheduling gangs of processors. User program and their gangs of processors are put to sleep and awakened by the gang scheduler to provide a time sharing environment. Time quantums are adjusted according to priority queues and a system of fair share accounting. The initial platform for this software is the 128 processor BBN TC2000 in use in the Massively Parallel Computing Initiative at the Lawrence Livermore National Laboratory. 2 refs., 1 fig.

  1. 5 CFR 532.254 - Special schedules.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... exist in the private sector that are incompatible with regular schedule practices, and serious... authorization for a special schedule shall include instructions for its construction, application,...

  2. Visualization on supercomputing platform level II ASC milestone (3537-1B) results from Sandia.

    SciTech Connect

    Geveci, Berk; Fabian, Nathan; Marion, Patrick; Moreland, Kenneth D.

    2010-09-01

    This report provides documentation for the completion of the Sandia portion of the ASC Level II Visualization on the platform milestone. This ASC Level II milestone is a joint milestone between Sandia National Laboratories and Los Alamos National Laboratories. This milestone contains functionality required for performing visualization directly on a supercomputing platform, which is necessary for peta-scale visualization. Sandia's contribution concerns in-situ visualization, running a visualization in tandem with a solver. Visualization and analysis of petascale data is limited by several factors which must be addressed as ACES delivers the Cielo platform. Two primary difficulties are: (1) Performance of interactive rendering, which is most computationally intensive portion of the visualization process. For terascale platforms, commodity clusters with graphics processors(GPUs) have been used for interactive rendering. For petascale platforms, visualization and rendering may be able to run efficiently on the supercomputer platform itself. (2) I/O bandwidth, which limits how much information can be written to disk. If we simply analyze the sparse information that is saved to disk we miss the opportunity to analyze the rich information produced every timestep by the simulation. For the first issue, we are pursuing in-situ analysis, in which simulations are coupled directly with analysis libraries at runtime. This milestone will evaluate the visualization and rendering performance of current and next generation supercomputers in contrast to GPU-based visualization clusters, and evaluate the performance of common analysis libraries coupled with the simulation that analyze and write data to disk during a running simulation. This milestone will explore, evaluate and advance the maturity level of these technologies and their applicability to problems of interest to the ASC program. Scientific simulation on parallel supercomputers is traditionally performed in four

  3. Automating Deep Space Network scheduling and conflict resolution

    NASA Technical Reports Server (NTRS)

    Johnston, Mark D.; Clement, Bradley

    2005-01-01

    The Deep Space Network (DSN) is a central part of NASA's infrastructure for communicating with active space missions, from earth orbit to beyond the solar system. We describe our recent work in modeling the complexities of user requirements, and then scheduling and resolving conflicts on that basis. We emphasize our innovative use of background 'intelligent' assistants' that carry out search asynchrnously while the user is focusing on various aspects of the schedule.

  4. Plug-In Hybrid Vehicle Analysis (Milestone Report)

    SciTech Connect

    Markel, T.; Brooker, A.; Gonder, J.; O'Keefe, M.; Simpson, A.; Thornton, M.

    2006-11-01

    NREL's plug-in hybrid electric vehicle (PHEV) analysis activities made great strides in FY06 to objectively assess PHEV technology, support the larger U.S. Department of Energy PHEV assessment effort, and share technical knowledge with the vehicle research community and vehicle manufacturers. This report provides research papers and presentations developed in FY06 to support these efforts. The report focuses on the areas of fuel economy reporting methods, cost and consumption benefit analysis, real-world performance expectations, and energy management strategies.

  5. Software Schedules Missions, Aids Project Management

    NASA Technical Reports Server (NTRS)

    2008-01-01

    NASA missions require advanced planning, scheduling, and management, and the Space Agency has worked extensively to develop the programs and software suites necessary to facilitate these complex missions. These enormously intricate undertakings have hundreds of active components that need constant management and monitoring. It is no surprise, then, that the software developed for these tasks is often applicable in other high-stress, complex environments, like in government or industrial settings. NASA work over the past few years has resulted in a handful of new scheduling, knowledge-management, and research tools developed under contract with one of NASA s partners. These tools have the unique responsibility of supporting NASA missions, but they are also finding uses outside of the Space Program.

  6. Progressive Ratio Schedules of Reinforcement

    PubMed Central

    Killeen, Peter R.; Posadas-Sanchez, Diana; Johansen, Espen Borgå; Thrailkill, Eric A.

    2009-01-01

    Pigeons’ pecks produced grain under progressive ratio (PR) schedules, whose response requirements increased systematically within sessions. Experiment 1 compared arithmetic (AP) and geometric (GP) progressions. Response rates increased as a function of the component ratio requirement, then decreased linearly (AP) or asymptotically (GP). Experiment 2 found the linear decrease in AP rates to be relatively independent of step size. Experiment 3 showed pausing to be controlled by the prior component length, which predicted the differences between PR and regressive ratio schedules found in Experiment 4. When the longest component ratios were signaled by different key colors, rates at moderate ratios increased, demonstrating control by forthcoming context. Models for response rate and pause duration described performance on AP schedules; GP schedules required an additional parameter representing the contextual reinforcement. PMID:19159161

  7. Milestones in Functional Titanium Dioxide Thermal Spray Coatings: A Review

    NASA Astrophysics Data System (ADS)

    Gardon, M.; Guilemany, J. M.

    2014-04-01

    Titanium dioxide has been the most investigated metal oxide due to its outstanding performance in a wide range of applications, chemical stability and low cost. Coating processes that can produce surfaces based on this material have been deeply studied. Nevertheless, the necessity of coating large areas by means of rapid manufacturing processes renders laboratory-scale techniques unsuitable, leading to a noteworthy interest from the thermal spray (TS) community in the development of significant intellectual property and a large number of scientific publications. This review unravels the relationship between titanium dioxide and TS technologies with the aim of providing detailed information related to the most significant achievements, lack of knowhow, and performance of TS TiO2 functional coatings in photocatalytic, biomedical, and other applications. The influence of thermally activated techniques such as atmospheric plasma spray and high-velocity oxygen fuel spray on TiO2 feedstock based on powders and suspensions is revised; the influence of spraying parameters on the microstructural and compositional changes and the final active behavior of the coating have been analyzed. Recent findings on titanium dioxide coatings deposited by cold gas spray and the capacity of this technology to prevent loss of the nanostructured anatase metastable phase are also reviewed.

  8. Future aircraft networks and schedules

    NASA Astrophysics Data System (ADS)

    Shu, Yan

    2011-07-01

    Because of the importance of air transportation scheduling, the emergence of small aircraft and the vision of future fuel-efficient aircraft, this thesis has focused on the study of aircraft scheduling and network design involving multiple types of aircraft and flight services. It develops models and solution algorithms for the schedule design problem and analyzes the computational results. First, based on the current development of small aircraft and on-demand flight services, this thesis expands a business model for integrating on-demand flight services with the traditional scheduled flight services. This thesis proposes a three-step approach to the design of aircraft schedules and networks from scratch under the model. In the first step, both a frequency assignment model for scheduled flights that incorporates a passenger path choice model and a frequency assignment model for on-demand flights that incorporates a passenger mode choice model are created. In the second step, a rough fleet assignment model that determines a set of flight legs, each of which is assigned an aircraft type and a rough departure time is constructed. In the third step, a timetable model that determines an exact departure time for each flight leg is developed. Based on the models proposed in the three steps, this thesis creates schedule design instances that involve almost all the major airports and markets in the United States. The instances of the frequency assignment model created in this thesis are large-scale non-convex mixed-integer programming problems, and this dissertation develops an overall network structure and proposes iterative algorithms for solving these instances. The instances of both the rough fleet assignment model and the timetable model created in this thesis are large-scale mixed-integer programming problems, and this dissertation develops subproblem schemes for solving these instances. Based on these solution algorithms, this dissertation also presents

  9. Planning and scheduling for success

    NASA Technical Reports Server (NTRS)

    Manzanera, Ignacio

    1994-01-01

    Planning and scheduling programs are excellent management tools when properly introduced to the project management team and regularly maintained. Communications, creativity, flexibility and accuracy are substantially improved by following a simple set of rules. A planning and scheduling program will work for you if you believe in it, make others in your project team realize its benefits, and make it an extension of your project cost control philosophy.

  10. Non-clairvoyant Scheduling Games

    NASA Astrophysics Data System (ADS)

    Dürr, Christoph; Nguyen, Kim Thang

    In a scheduling game, each player owns a job and chooses a machine to execute it. While the social cost is the maximal load over all machines (makespan), the cost (disutility) of each player is the completion time of its own job. In the game, players may follow selfish strategies to optimize their cost and therefore their behaviors do not necessarily lead the game to an equilibrium. Even in the case there is an equilibrium, its makespan might be much larger than the social optimum, and this inefficiency is measured by the price of anarchy - the worst ratio between the makespan of an equilibrium and the optimum. Coordination mechanisms aim to reduce the price of anarchy by designing scheduling policies that specify how jobs assigned to a same machine are to be scheduled. Typically these policies define the schedule according to the processing times as announced by the jobs. One could wonder if there are policies that do not require this knowledge, and still provide a good price of anarchy. This would make the processing times be private information and avoid the problem of truthfulness. In this paper we study these so-called non-clairvoyant policies. In particular, we study the RANDOM policy that schedules the jobs in a random order without preemption, and the EQUI policy that schedules the jobs in parallel using time-multiplexing, assigning each job an equal fraction of CPU time.

  11. 77 FR 64848 - Proposed Collection; Comment Request for Form 1120S, Schedule D, Schedule K-1, and Schedule M-3

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-23

    ... Internal Revenue Service Proposed Collection; Comment Request for Form 1120S, Schedule D, Schedule K-1, and... With Total Assets of $10 Million or More, and Schedule K-1 (Form 1120S), Shareholder's Share of Income... Losses and Built-in Gains, Schedule K-1 (Form 1120S), Shareholder's Share of Income, Credits,...

  12. Cornerstone Documents, Milestones, and Policies: Shaping the Direction of Public Health Nursing 1890-1950.

    PubMed

    Kub, Joan; Kulbok, Pamela A; Glick, Doris

    2015-05-01

    The interplay of policy, milestone events, and cornerstone documents was critical in the evolution of the specialty of public health nursing (PHN) from 1890-1950. Using our contemporary lens, this article examines PHN development from an historical perspective, including events and milestones driving growth in the early 20th century. Some of the challenges faced by our founding public health nursing leadership are not unlike challenges we face today. In 1950, Ruth Hubbard, a former leader in the National Organization of Public Health Nurses and Director of the Visiting Nurse Society of Philadelphia, spoke of the value of examining the past to forge a new future. This article calls for contemporary public health nurses to act upon the lessons learned from the past, to strengthen the renewed focus on prevention, to develop policies that impact population health, and to foster a vision that will guide us into the future. PMID:26882422

  13. Milestones in Software Engineering and Knowledge Engineering History: A Comparative Review

    PubMed Central

    del Águila, Isabel M.; Palma, José; Túnez, Samuel

    2014-01-01

    We present a review of the historical evolution of software engineering, intertwining it with the history of knowledge engineering because “those who cannot remember the past are condemned to repeat it.” This retrospective represents a further step forward to understanding the current state of both types of engineerings; history has also positive experiences; some of them we would like to remember and to repeat. Two types of engineerings had parallel and divergent evolutions but following a similar pattern. We also define a set of milestones that represent a convergence or divergence of the software development methodologies. These milestones do not appear at the same time in software engineering and knowledge engineering, so lessons learned in one discipline can help in the evolution of the other one. PMID:24624046

  14. Milestones in software engineering and knowledge engineering history: a comparative review.

    PubMed

    del Águila, Isabel M; Palma, José; Túnez, Samuel

    2014-01-01

    We present a review of the historical evolution of software engineering, intertwining it with the history of knowledge engineering because "those who cannot remember the past are condemned to repeat it." This retrospective represents a further step forward to understanding the current state of both types of engineerings; history has also positive experiences; some of them we would like to remember and to repeat. Two types of engineerings had parallel and divergent evolutions but following a similar pattern. We also define a set of milestones that represent a convergence or divergence of the software development methodologies. These milestones do not appear at the same time in software engineering and knowledge engineering, so lessons learned in one discipline can help in the evolution of the other one.

  15. Post-processing V&V level II ASC milestone (2360) results.

    SciTech Connect

    Chavez, Elmer; Karelitz, David B.; Brunner, Thomas A.; Trucano, Timothy Guy; Moreland, Kenneth D.; Weirs, V. Gregory; Shead, Timothy M.

    2007-09-01

    The 9/30/2007 ASC Level 2 Post-Processing V&V Milestone (Milestone 2360) contains functionality required by the user community for certain verification and validation tasks. These capabilities include loading of edge and face data on an Exodus mesh, run-time computation of an exact solution to a verification problem, delivery of results data from the server to the client, computation of an integral-based error metric, simultaneous loading of simulation and test data, and comparison of that data using visual and quantitative methods. The capabilities were tested extensively by performing a typical ALEGRA HEDP verification task. In addition, a number of stretch criteria were met including completion of a verification task on a 13 million element mesh.

  16. The early antibiotic therapy in septic patients--milestone or sticking point?

    PubMed

    Bernhard, Michael; Lichtenstern, Christoph; Eckmann, Christian; Weigand, Markus A

    2014-01-01

    Sepsis is one of the oldest and most elusive syndromes in medicine. Every effort should be made to treat these patients with the best available evidence. As a milestone, empiric antimicrobial therapy is essential in order to reduce morbidity and mortality of septic patients. As a sticking point, the use of broad-spectrum antimicrobial agents may be associated with induction of resistance among common pathogens. PMID:25672873

  17. Apollo experience report the command and service module milestone review process

    NASA Technical Reports Server (NTRS)

    Brendle, H. L.; York, J. A.

    1974-01-01

    The sequence of the command and service module milestone review process is given, and the Customer Acceptance Readiness Review and Flight Readiness Review plans are presented. Contents of the System Summary Acceptance Documents for the two formal spacecraft reviews are detailed, and supplemental data required for presentation to the review boards are listed. Typical forms, correspondence, supporting documentation, and minutes of a board meeting are included.

  18. Putting the pediatrics milestones into practice: a consensus roadmap and resource analysis.

    PubMed

    Schumacher, Daniel J; Spector, Nancy D; Calaman, Sharon; West, Daniel C; Cruz, Mario; Frohna, John G; Gonzalez Del Rey, Javier; Gustafson, Kristina K; Poynter, Sue Ellen; Rosenbluth, Glenn; Southgate, W Michael; Vinci, Robert J; Sectish, Theodore C

    2014-05-01

    The Accreditation Council for Graduate Medical Education has partnered with member boards of the American Board of Medical Specialties to initiate the next steps in advancing competency-based assessment in residency programs. This initiative, known as the Milestone Project, is a paradigm shift from traditional assessment efforts and requires all pediatrics residency programs to report individual resident progression along a series of 4 to 5 developmental levels of performance, or milestones, for individual competencies every 6 months beginning in June 2014. The effort required to successfully make this shift is tremendous given the number of training programs, training institutions, and trainees. However, it holds great promise for achieving training outcomes that align with patient needs; developing a valid, reliable, and meaningful way to track residents' development; and providing trainees with a roadmap for learning. Recognizing the resources needed to implement this new system, the authors, all residency program leaders, provide their consensus view of the components necessary for implementing and sustaining this effort, including resource estimates for completing this work. The authors have identified 4 domains: (1) Program Review and Development of Stakeholders and Participants, (2) Assessment Methods and Validation, (3) Data and Assessment System Development, and (4) Summative Assessment and Feedback. This work can serve as a starting point and framework for collaboration with program, department, and institutional leaders to identify and garner necessary resources and plan for local and national efforts that will ensure successful transition to milestones-based assessment.

  19. Planning for Pre-Exascale Platform Environment (Fiscal Year 2015 Level 2 Milestone 5216)

    SciTech Connect

    Springmeyer, R.; Lang, M.; Noe, J.

    2015-09-28

    This Plan for ASC Pre-Exascale Platform Environments document constitutes the deliverable for the fiscal year 2015 (FY15) Advanced Simulation and Computing (ASC) Program Level 2 milestone Planning for Pre-Exascale Platform Environment. It acknowledges and quantifies challenges and recognized gaps for moving the ASC Program towards effective use of exascale platforms and recommends strategies to address these gaps. This document also presents an update to the concerns, strategies, and plans presented in the FY08 predecessor document that dealt with the upcoming (at the time) petascale high performance computing (HPC) platforms. With the looming push towards exascale systems, a review of the earlier document was appropriate in light of the myriad architectural choices currently under consideration. The ASC Program believes the platforms to be fielded in the 2020s will be fundamentally different systems that stress ASC’s ability to modify codes to take full advantage of new or unique features. In addition, the scale of components will increase the difficulty of maintaining an errorfree system, thus driving new approaches to resilience and error detection/correction. The code revamps of the past, from serial- to vector-centric code to distributed memory to threaded implementations, will be revisited as codes adapt to a new message passing interface (MPI) plus “x” or more advanced and dynamic programming models based on architectural specifics. Development efforts are already underway in some cases, and more difficult or uncertain aspects of the new architectures will require research and analysis that may inform future directions for program choices. In addition, the potential diversity of system architectures may require parallel if not duplicative efforts to analyze and modify environments, codes, subsystems, libraries, debugging tools, and performance analysis techniques as well as exploring new monitoring methodologies. It is difficult if not impossible to

  20. Milestones on the way to a reconfigurable automotive instrument cluster

    NASA Astrophysics Data System (ADS)

    Knoll, Peter M.; Kosmowski, Bogdan B.

    2002-06-01

    Nowadays, the car driver are faced with a rapidly increasing flood of information. In addition to established information systems (car radio, vehicle monitoring, mobile phones), high class vehicles feature navigation systems almost as standard. In the current decade, driver assistance and collision avoidance systems will appear in vehicles. Hence, there is an increasing demand for supplying the driver with more information that help him to drive safer and more economical. The price decline in the computer market and the availability of powerful graphic hard- and software concepts make it possible to enhance the classical functions of the instrument board to an interactive multifunctional information panel - an interface between information systems of the car and the driver. Therefore, the question of additional visual and cognitive stress, and a possible distraction of the driver by the large amount of information, and its complexity becomes predominant. Reconfigurable instruments, based on a microprocessor controlled active matrix color display, provide a powerful alternative to the usual mechanical/electromechanical instrument clusters in vehicles. They will help to strengthen passive safety, they adapt to user and situation requirements, and they are easy to install, to configure, and to maintain. Reconfigurable instruments in future cars will have a high impact on traffic since they can provide the driver with much more information, presenting it in a way that is flexibly matched to the importance of particular data and to the ergonomic properties of the driver. The functions are manifold and span from classical driver information like speed to navigation prompts and ultimately to video and multimedia access.

  1. RAVEN. Dynamic Event Tree Approach Level III Milestone

    SciTech Connect

    Alfonsi, Andrea; Rabiti, Cristian; Mandelli, Diego; Cogliati, Joshua; Kinoshita, Robert

    2014-07-01

    Conventional Event-Tree (ET) based methodologies are extensively used as tools to perform reliability and safety assessment of complex and critical engineering systems. One of the disadvantages of these methods is that timing/sequencing of events and system dynamics are not explicitly accounted for in the analysis. In order to overcome these limitations several techniques, also know as Dynamic Probabilistic Risk Assessment (DPRA), have been developed. Monte-Carlo (MC) and Dynamic Event Tree (DET) are two of the most widely used D-PRA methodologies to perform safety assessment of Nuclear Power Plants (NPP). In the past two years, the Idaho National Laboratory (INL) has developed its own tool to perform Dynamic PRA: RAVEN (Reactor Analysis and Virtual control ENvironment). RAVEN has been designed to perform two main tasks: 1) control logic driver for the new Thermo-Hydraulic code RELAP-7 and 2) post-processing tool. In the first task, RAVEN acts as a deterministic controller in which the set of control logic laws (user defined) monitors the RELAP-7 simulation and controls the activation of specific systems. Moreover, the control logic infrastructure is used to model stochastic events, such as components failures, and perform uncertainty propagation. Such stochastic modeling is deployed using both MC and DET algorithms. In the second task, RAVEN processes the large amount of data generated by RELAP-7 using data-mining based algorithms. This report focuses on the analysis of dynamic stochastic systems using the newly developed RAVEN DET capability. As an example, a DPRA analysis, using DET, of a simplified pressurized water reactor for a Station Black-Out (SBO) scenario is presented.

  2. RAVEN: Dynamic Event Tree Approach Level III Milestone

    SciTech Connect

    Andrea Alfonsi; Cristian Rabiti; Diego Mandelli; Joshua Cogliati; Robert Kinoshita

    2013-07-01

    Conventional Event-Tree (ET) based methodologies are extensively used as tools to perform reliability and safety assessment of complex and critical engineering systems. One of the disadvantages of these methods is that timing/sequencing of events and system dynamics are not explicitly accounted for in the analysis. In order to overcome these limitations several techniques, also know as Dynamic Probabilistic Risk Assessment (DPRA), have been developed. Monte-Carlo (MC) and Dynamic Event Tree (DET) are two of the most widely used D-PRA methodologies to perform safety assessment of Nuclear Power Plants (NPP). In the past two years, the Idaho National Laboratory (INL) has developed its own tool to perform Dynamic PRA: RAVEN (Reactor Analysis and Virtual control ENvironment). RAVEN has been designed to perform two main tasks: 1) control logic driver for the new Thermo-Hydraulic code RELAP-7 and 2) post-processing tool. In the first task, RAVEN acts as a deterministic controller in which the set of control logic laws (user defined) monitors the RELAP-7 simulation and controls the activation of specific systems. Moreover, the control logic infrastructure is used to model stochastic events, such as components failures, and perform uncertainty propagation. Such stochastic modeling is deployed using both MC and DET algorithms. In the second task, RAVEN processes the large amount of data generated by RELAP-7 using data-mining based algorithms. This report focuses on the analysis of dynamic stochastic systems using the newly developed RAVEN DET capability. As an example, a DPRA analysis, using DET, of a simplified pressurized water reactor for a Station Black-Out (SBO) scenario is presented.

  3. E-Scheduling the Deep Space Network

    NASA Technical Reports Server (NTRS)

    Smith, Jeffrey H.; Wang, Yeou-Fang

    2001-01-01

    This paper describes an operations concept for electronic scheduling and software interface for organizations to extract required views of the schedule. Advantages include widespread accessibility to a common schedule document, virtually instantaneous distribution of new schedule releases, and the ability of missions to perfom conflict resolution off-line without time-consuming meetings.

  4. 20 CFR 411.580 - Can an EN receive payments for milestones or outcome payment months that occur before the...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ....580 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM Employment Network Payment Systems § 411.580 Can an EN receive payments for milestones or outcome...

  5. 20 CFR 411.580 - Can an EN receive payments for milestones or outcome payment months that occur before the...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ....580 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM Employment Network Payment Systems § 411.580 Can an EN receive payments for milestones or outcome...

  6. Prioritizing sleep for healthy work schedules

    PubMed Central

    2012-01-01

    Good sleep is advantageous to the quality of life. Sleep-related benefits are particularly helpful for the working class, since poor or inadequate amounts of sleep degrade work productivity and overall health. This review paper explores the essential role of sleep in healthy work schedules and primarily focuses on the timing of sleep in relation to the work period (that is, before, during and after work). Data from laboratory, field and modeling studies indicate that consistent amounts of sleep prior to work are fundamental to improved performance and alertness in the workplace. In addition, planned naps taken during work maintain appropriate levels of waking function for both daytime and night-time work. Clearly, sufficient sleep after work is vital in promoting recovery from fatigue. Recent data also suggest that the time interval between shifts should be adjusted according to the biological timing of sleep. Although sleep is more likely to be replaced by job and other activities in the real life, research shows that it is worthwhile to revise the work schedules in order to optimize sleep before, sometime during and after the work period. Therefore, we suggest establishing work-sleep balance, similar to work-life balance, as a principle for designing and improving work schedules. PMID:22738292

  7. Predit: A temporal predictive framework for scheduling systems

    NASA Technical Reports Server (NTRS)

    Paolucci, E.; Patriarca, E.; Sem, M.; Gini, G.

    1992-01-01

    Scheduling can be formalized as a Constraint Satisfaction Problem (CSP). Within this framework activities belonging to a plan are interconnected via temporal constraints that account for slack among them. Temporal representation must include methods for constraints propagation and provide a logic for symbolic and numerical deductions. In this paper we describe a support framework for opportunistic reasoning in constraint directed scheduling. In order to focus the attention of an incremental scheduler on critical problem aspects, some discrete temporal indexes are presented. They are also useful for the prediction of the degree of resources contention. The predictive method expressed through our indexes can be seen as a Knowledge Source for an opportunistic scheduler with a blackboard architecture.

  8. Continental transform margins : state of art and future milestones

    NASA Astrophysics Data System (ADS)

    Basile, Christophe

    2010-05-01

    Transform faults were defined 45 years ago as ‘a new class of fault' (Wilson, 1965), and transform margins were consequently individualized as a new class of continental margins. While transform margins represent 20 to 25 % of the total length of continent-ocean transitions, they were poorly studied, especially when compared with the amount of data, interpretations, models and conceptual progress accumulated on divergent or convergent continental margins. The best studied examples of transform margins are located in the northern part of Norway, south of South Africa, in the gulf of California and on both sides of the Equatorial Atlantic. Here is located the Côte d'Ivoire - Ghana margin, where the more complete data set was acquired, based on numerous geological and geophysical cruises, including ODP Leg 159. The first models that encompassed the structure and evolution of transform margins were mainly driven by plate kinematic reconstructions, and evidenced the diachronic end of tectonic activity and the non-cylindrical character of these margins, with a decreasing strike-slip deformation from the convex to the concave divergent-transform intersections. Further thermo-mechanical models were more specifically designed to explain the vertical displacements along transform margins, and especially the occurrence of high-standing marginal ridges. These thermo-mechanical models involved either heat transfer from oceanic to continental lithospheres across the transform faults or tectonically- or gravity-driven mass transfer in the upper crust. These models were far from fully fit observations, and were frequently dedicated to specific example, and not easily generalizable. Future work on transform continental margins may be expected to fill some scientific gaps, and the definition of working directions can benefit from the studies dedicated to other types of margins. At regional scale the structural and sedimentological variability of transform continental margins has

  9. Schedules of controlled substances: temporary placement of three synthetic phenethylamines into Schedule I. Final order.

    PubMed

    2013-11-15

    The Deputy Administrator of the Drug Enforcement Administration (DEA) is issuing this final order to temporarily schedule three synthetic phenethylamines into the Controlled Substances Act (CSA) pursuant to the temporary scheduling provisions of 21 U.S.C. 811(h). The substances are 2-(4-iodo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine (25I-NBOMe; 2C-I-NBOMe; 25I; Cimbi-5), 2-(4-chloro-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine (25C-NBOMe; 2C-C-NBOMe; 25C; Cimbi-82), and 2-(4-bromo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine (25B-NBOMe; 2C-B-NBOMe; 25B; Cimbi-36) [hereinafter 25I-NBOMe, 25C-NBOMe, and 25B-NBOMe]. This action is based on a finding by the Deputy Administrator that the placement of these synthetic phenethylamines and their optical, positional, and geometric isomers, salts and salts of isomers in schedule I of the CSA is necessary to avoid an imminent hazard to the public safety. As a result of this order, the regulatory controls and administrative, civil, and criminal sanctions applicable to schedule I controlled substances will be imposed on persons who handle (manufacture, distribute, dispense, import, export, engage in research, conduct instructional activities, and possess), or propose to handle these synthetic phenethylamines.

  10. Spike: AI scheduling for Hubble Space Telescope after 18 months of orbital operations

    NASA Technical Reports Server (NTRS)

    Johnston, Mark D.

    1992-01-01

    This paper is a progress report on the Spike scheduling system, developed by the Space Telescope Science Institute for long-term scheduling of Hubble Space Telescope (HST) observations. Spike is an activity-based scheduler which exploits artificial intelligence (AI) techniques for constraint representation and for scheduling search. The system has been in operational use since shortly after HST launch in April 1990. Spike was adopted for several other satellite scheduling problems; of particular interest was the demonstration that the Spike framework is sufficiently flexible to handle both long-term and short-term scheduling, on timescales of years down to minutes or less. We describe the recent progress made in scheduling search techniques, the lessons learned from early HST operations, and the application of Spike to other problem domains. We also describe plans for the future evolution of the system.

  11. Scheduler software for tracking and data relay satellite system loading analysis: User manual and programmer guide

    NASA Technical Reports Server (NTRS)

    Craft, R.; Dunn, C.; Mccord, J.; Simeone, L.

    1980-01-01

    A user guide and programmer documentation is provided for a system of PRIME 400 minicomputer programs. The system was designed to support loading analyses on the Tracking Data Relay Satellite System (TDRSS). The system is a scheduler for various types of data relays (including tape recorder dumps and real time relays) from orbiting payloads to the TDRSS. Several model options are available to statistically generate data relay requirements. TDRSS time lines (representing resources available for scheduling) and payload/TDRSS acquisition and loss of sight time lines are input to the scheduler from disk. Tabulated output from the interactive system includes a summary of the scheduler activities over time intervals specified by the user and overall summary of scheduler input and output information. A history file, which records every event generated by the scheduler, is written to disk to allow further scheduling on remaining resources and to provide data for graphic displays or additional statistical analysis.

  12. Space network scheduling benchmark: A proof-of-concept process for technology transfer

    NASA Technical Reports Server (NTRS)

    Moe, Karen; Happell, Nadine; Hayden, B. J.; Barclay, Cathy

    1993-01-01

    This paper describes a detailed proof-of-concept activity to evaluate flexible scheduling technology as implemented in the Request Oriented Scheduling Engine (ROSE) and applied to Space Network (SN) scheduling. The criteria developed for an operational evaluation of a reusable scheduling system is addressed including a methodology to prove that the proposed system performs at least as well as the current system in function and performance. The improvement of the new technology must be demonstrated and evaluated against the cost of making changes. Finally, there is a need to show significant improvement in SN operational procedures. Successful completion of a proof-of-concept would eventually lead to an operational concept and implementation transition plan, which is outside the scope of this paper. However, a high-fidelity benchmark using actual SN scheduling requests has been designed to test the ROSE scheduling tool. The benchmark evaluation methodology, scheduling data, and preliminary results are described.

  13. Artificial intelligence approaches to astronomical observation scheduling

    NASA Technical Reports Server (NTRS)

    Johnston, Mark D.; Miller, Glenn

    1988-01-01

    Automated scheduling will play an increasing role in future ground- and space-based observatory operations. Due to the complexity of the problem, artificial intelligence technology currently offers the greatest potential for the development of scheduling tools with sufficient power and flexibility to handle realistic scheduling situations. Summarized here are the main features of the observatory scheduling problem, how artificial intelligence (AI) techniques can be applied, and recent progress in AI scheduling for Hubble Space Telescope.

  14. Batch Scheduling a Fresh Approach

    NASA Technical Reports Server (NTRS)

    Cardo, Nicholas P.; Woodrow, Thomas (Technical Monitor)

    1994-01-01

    The Network Queueing System (NQS) was designed to schedule jobs based on limits within queues. As systems obtain more memory, the number of queues increased to take advantage of the added memory resource. The problem now becomes too many queues. Having a large number of queues provides users with the capability to gain an unfair advantage over other users by tailoring their job to fit in an empty queue. Additionally, the large number of queues becomes confusing to the user community. The High Speed Processors group at the Numerical Aerodynamics Simulation (NAS) Facility at NASA Ames Research Center developed a new approach to batch job scheduling. This new method reduces the number of queues required by eliminating the need for queues based on resource limits. The scheduler examines each request for necessary resources before initiating the job. Also additional user limits at the complex level were added to provide a fairness to all users. Additional tools which include user job reordering are under development to work with the new scheduler. This paper discusses the objectives, design and implementation results of this new scheduler

  15. Environmental surveillance master sampling schedule

    SciTech Connect

    Bisping, L.E.

    1991-01-01

    Environmental surveillance of the Hanford Site and surrounding areas is conducted by the Pacific Northwest Laboratory (PNL) for the US Department of Energy (DOE). This document contains the planned schedule for routine sample collection for the Surface Environmental Surveillance Project (SESP) and Ground-Water Monitoring Project. The routine sampling plan for the SESP has been revised this year to reflect changing site operations and priorities. Some sampling previously performed at least annually has been reduced in frequency, and some new sampling to be performed at a less than annual frequency has been added. Therefore, the SESP schedule reflects sampling to be conducted in calendar year 1991 as well as future years. The ground-water sampling schedule is for 1991. This schedule is subject to modification during the year in response to changes in Site operation, program requirements, and the nature of the observed results. Operational limitations such as weather, mechanical failures, sample availability, etc., may also require schedule modifications. Changes will be documented in the respective project files, but this plan will not be reissued. The purpose of these monitoring projects is to evaluate levels of radioactive and nonradioactive pollutants in the Hanford evirons.

  16. Use of Developmental Milestones in Pediatric Residency Training and Practice: Time to Rethink the Meaning of the Mean

    PubMed Central

    Sices, Laura

    2009-01-01

    Objective Pediatricians frequently report the use of developmental milestones in monitoring young children’s development, despite evidence that use of screening tools improves detection of developmental delays. Methods Core texts in the field of pediatrics and developmental-behavioral pediatrics were reviewed for content and presentation on child development. Most texts included and many focused on developmental milestones, many with an emphasis on 50th percentile milestone data. Problems and limitations in the use of 50th percentile milestones to monitor young children’s development and to identify children whose development is suspicious for delay, include questionable utility in clinical decision making and the potential to increase parental anxiety. Results The recommendation is made to reconsider a focus on 50th percentile milestone data in pediatric training and practice, in favor of measures that have better clinical utility and are more psychometrically sound. Conclusion A conceptual approach to the presentation of developmental milestones differentiates the use of the 10th, 50th, and 90th percentiles of age of achievement of skills, based on the clinical purpose of surveillance. PMID:17353732

  17. Greater length-for-age increases the odds of attaining motor milestones in Vietnamese children aged 5-18 months.

    PubMed

    Kulkarni, Shibani; Ramakrishnan, Usha; Dearden, Kirk A; Marsh, David R; Ha, Tran Thu; Tran, Thach Duc; Pachón, Helena

    2012-01-01

    Early childhood malnutrition has been associated with delayed development. Limited data exist however about the timing of developmental delay early in life. We assessed motor milestone (MM) achievement using the World Health Organization's windows of achievement for gross motor milestones. We performed secondary analysis of baseline data of 158 Vietnamese children aged 5-18 months from a randomized community intervention trial. Median age of motor milestone achievement was compared to WHO reported medians. Multivariate logistic regression was used to identify socioeconomic, anthropometric and dietary factors associated with motor milestone achievement during the windows of achievement. Thirty four per cent of the children were stunted. Median age of MM achievement of Vietnamese children lagged by 2.4-3.7 months, compared to the WHO median for all MMs. Greater length-for-age increased the odds for walking with assistance, standing alone and walking alone by more than 3 times. Greater weight-for-age increased the odds by 3.6 for hand-and-knees crawling. Likewise, frequency of daily complementary feeding raised the odds by 3.6 for standing with assistance. In this first application of WHO windows of achievement in Viet Nam, pre-schoolers achieved motor milestones later than WHO reported median age. High prevalence of stunting and association of length-for-age with motor milestone achievement underscore the importance of addressing chronic malnutrition to optimize children's growth and development.

  18. A Generic Expert Scheduling System Architecture and Toolkit: GUESS (Generically Used Expert Scheduling System)

    NASA Technical Reports Server (NTRS)

    Liebowitz, Jay; Krishnamurthy, Vijaya; Rodens, Ira; Houston, Chapman; Liebowitz, Alisa; Baek, Seung; Radko, Joe; Zeide, Janet

    1996-01-01

    Scheduling has become an increasingly important element in today's society and workplace. Within the NASA environment, scheduling is one of the most frequently performed and challenging functions. Towards meeting NASA's scheduling needs, a research version of a generic expert scheduling system architecture and toolkit has been developed. This final report describes the development and testing of GUESS (Generically Used Expert Scheduling System).

  19. Computerized Schedule Effectiveness Technique /SET/ determines present and future schedule position

    NASA Technical Reports Server (NTRS)

    Ballard, D.; Birdsong, J.; Calva, R.

    1967-01-01

    Computerized scheduling system calculates an index of overall schedule-effectiveness. The schedule-effectiveness index is a measurement of actual overall performance against the existing schedule, and a series of schedule-effectiveness values indicates the trend of actual performance. This computer program is written in Fortran 4.

  20. Optimal randomized scheduling by replacement

    SciTech Connect

    Saias, I.

    1996-05-01

    In the replacement scheduling problem, a system is composed of n processors drawn from a pool of p. The processors can become faulty while in operation and faulty processors never recover. A report is issued whenever a fault occurs. This report states only the existence of a fault but does not indicate its location. Based on this report, the scheduler can reconfigure the system and choose another set of n processors. The system operates satisfactorily as long as, upon report of a fault, the scheduler chooses n non-faulty processors. We provide a randomized protocol maximizing the expected number of faults the system can sustain before the occurrence of a crash. The optimality of the protocol is established by considering a closely related dual optimization problem. The game-theoretic technical difficulties that we solve in this paper are very general and encountered whenever proving the optimality of a randomized algorithm in parallel and distributed computation.

  1. Environmental surveillance master sampling schedule

    SciTech Connect

    Bisping, L.E.

    1997-01-01

    Environmental surveillance of the Hanford Site and surrounding areas is conducted by the Pacific Northwest National Laboratory (PNNL)(a) for the US Department of Energy (DOE). This document contains the planned 1997 schedules for routine collection of samples for the Surface Environmental Surveillance Project (SESP) and Drinking Water Monitoring Project. In addition, Section 3.0, Biota, also reflects a rotating collection schedule identifying the year a specific sample is scheduled for collection. The purpose of these monitoring projects is to evaluate levels of radioactive and nonradioactive pollutants in the Hanford environs, as required in DOE Order 5400.1, General Environmental Protection Program, and DOE Order 5400.5, Radiation Protection of the Public and the Environment. The sampling methods will be the same as those described in the Environmental Monitoring Plan, US Department of Energy, Richland Operations Office, DOE/RL91-50, Rev. 1, US Department of Energy, Richland, Washington.

  2. [Fee schedules and cost containment].

    PubMed

    Herrmann, François R; Perneger, Thomas

    2009-11-11

    Medical fee schedules are controversial. In this paper we examine the reasons that justify the imposition of fee schedules in the presence of a socially financed health insurance system, and examine the ways of constructing a medical fee schedule. The weakness of fee-for-service tariffs is that they do not allow a control of health care costs if the volume of services is unchecked. Current solutions to this problem--audit of doctors' average cost per case, freeze on new medical practices, or the insurers' discretion in choosing the doctors they reimburse--have multiple drawbacks. Alternatives to fee-for-service payment--such as flat fees, or payment based on the quality of medical services--are discussed.

  3. The Use of the Hanford Onsite Packaging and Transportation Safety Program to Meet Cleanup Milestones Under the Hanford Site Cleanup 2015 Vision and the American Recovery and Reinvestment Act of 2009 - 12403

    SciTech Connect

    Lavender, John C.; Edwards, W. Scott; Macbeth, Paul J.; Self, Richard J.; West, Lori D.

    2012-07-01

    The Hanford Site presents unique challenges in meeting the U.S. Department of Energy Richland Operations Office (DOE-RL) 2015 Cleanup Vision. CH2M Hill Plateau Remediation Company (CHPRC), its subcontractors, and DOE-RL were challenged to retrieve, transport and remediate a wide range of waste materials. Through a collaborative effort by all Hanford Onsite Central Plateau Cleanup Team Members, disposition pathways for diverse and seemingly impossible to ship wastes were developed under a DOE Order 460.1C-compliant Hanford Onsite Transportation Safety Program. The team determined an effective method for transporting oversized compliant waste payloads to processing and disposition facilities. The use of the onsite TSD packaging authorizations proved to be vital to safely transporting these materials for processing and eventual final disposition. The American Recovery and Reinvestment Act of 2009 (ARRA) provided additional resources to expedite planning and execution of these important cleanup milestones. Through the innovative and creative use of the TSD, the Hanford Onsite Central Plateau Cleanup Team Members have developed and are executing an integrated project plan that enables the safe and compliant transport of a wide variety of difficult-to-transport waste items, accelerating previous cleanup schedules to meet cleanup milestones. (authors)

  4. GME Milestone.

    PubMed

    Sorrel, Amy Lynn

    2016-01-01

    Thanks to years of TMA advocacy, the 2015 legislature more than tripled 2013 graduate medical education monies under an expansion initiative to help secure a pathway for doctors-in-training to enter the workforce. PMID:27532810

  5. GME Milestone.

    PubMed

    Sorrel, Amy Lynn

    2016-08-01

    Thanks to years of TMA advocacy, the 2015 legislature more than tripled 2013 graduate medical education monies under an expansion initiative to help secure a pathway for doctors-in-training to enter the workforce.

  6. Developmental Milestones

    MedlinePlus

    ... think there’s a problem. Watch the video » Child Development: It’s Better to Know (in Spanish) Learn why ... to do if you have concerns about your child's development. Watch this Spanish language video » Related Pages ...

  7. 36 CFR 1225.12 - How are records schedules developed?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... activity to identify records series, systems, and nonrecord materials. (c) Determine the appropriate scope of the records schedule items, e.g., individual series/system component, work process, group of... or work process analysis to identify the functions or activities performed by each organization...

  8. A planning and scheduling lexicon

    NASA Technical Reports Server (NTRS)

    Cruz, Jennifer W.; Eggemeyer, William C.

    1989-01-01

    A lexicon related to mission planning and scheduling for spacecraft is presented. Planning and scheduling work is known as sequencing. Sequencing is a multistage process of merging requests from both the science and engineering arenas to accomplish the objectives defined in the requests. The multistage process begins with the creation of science and engineering goals, continues through their integration into the sequence, and eventually concludes with command execution onboard the spacecraft. The objective of this publication is to introduce some formalism into the field of spacecraft sequencing-system technology. This formalism will make it possible for researchers and potential customers to communicate about system requirements and capabilities in a common language.

  9. Hubble Systems Optimize Hospital Schedules

    NASA Technical Reports Server (NTRS)

    2009-01-01

    Don Rosenthal, a former Ames Research Center computer scientist who helped design the Hubble Space Telescope's scheduling software, co-founded Allocade Inc. of Menlo Park, California, in 2004. Allocade's OnCue software helps hospitals reclaim unused capacity and optimize constantly changing schedules for imaging procedures. After starting to use the software, one medical center soon reported noticeable improvements in efficiency, including a 12 percent increase in procedure volume, 35 percent reduction in staff overtime, and significant reductions in backlog and technician phone time. Allocade now offers versions for outpatient and inpatient magnetic resonance imaging (MRI), ultrasound, interventional radiology, nuclear medicine, Positron Emission Tomography (PET), radiography, radiography-fluoroscopy, and mammography.

  10. Sleep and circadian schedule disorders.

    PubMed

    Labyak, Susan

    2002-12-01

    The timing and synchronization of human circadian rhythms is important for health and well-being. Some individuals, for reasons that remain unclear, display less resilience or flexibility in their ability to synchronize to the 24-hour world and are thus diagnosed with a circadian schedule disorder. The objective of this article is to briefly introduce concepts about human circadian timing and to review what is known about chronic, long-term circadian schedule disorders such as delayed sleep phase syndrome, advanced sleep phase syndrome, irregular sleep-wake patterns, and non-24-hour sleep-wake disorder. Practical considerations for the clinician caring for these individuals are discussed. PMID:12587363

  11. 7 CFR 3560.353 - Scheduling of on-site monitoring reviews.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Scheduling of on-site monitoring reviews. 3560.353....353 Scheduling of on-site monitoring reviews. Generally, the Agency will provide the borrower prior... physical conditions, operations and management activities, or other borrower or tenant activities....

  12. Reframing Class Scheduling: Seven School Counselor Benefits, Challenges, Considerations, and Recommendations

    ERIC Educational Resources Information Center

    Wines, Lisa; Nelson, Judith A.; Eckstein, Daniel

    2007-01-01

    The American School Counseling Association (ASCA) identifies scheduling students for classes as a non-counseling activity. Ideally, school counselors should limit non-counseling activities, but the reality is that counselors do in fact spend much time and energy scheduling classes, according to a recent survey of secondary counselors. We introduce…

  13. 15 CFR 714.6 - Deadlines for submission of Schedule 3 declarations, reports, and amendments.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ACTIVITIES INVOLVING SCHEDULE 3 CHEMICALS § 714.6 Deadlines for submission... past activities (production of Schedule 3 chemicals during the previous calendar year); (b)...

  14. 15 CFR 714.6 - Deadlines for submission of Schedule 3 declarations, reports, and amendments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ACTIVITIES INVOLVING SCHEDULE 3 CHEMICALS § 714.6 Deadlines for submission... past activities (production of Schedule 3 chemicals during the previous calendar year); (b)...

  15. 15 CFR 714.6 - Deadlines for submission of Schedule 3 declarations, reports, and amendments.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ACTIVITIES INVOLVING SCHEDULE 3 CHEMICALS § 714.6 Deadlines for submission... past activities (production of Schedule 3 chemicals during the previous calendar year); (b)...

  16. 15 CFR 714.6 - Deadlines for submission of Schedule 3 declarations, reports, and amendments.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ACTIVITIES INVOLVING SCHEDULE 3 CHEMICALS § 714.6 Deadlines for submission... past activities (production of Schedule 3 chemicals during the previous calendar year); (b)...

  17. 15 CFR 714.6 - Deadlines for submission of Schedule 3 declarations, reports, and amendments.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ACTIVITIES INVOLVING SCHEDULE 3 CHEMICALS § 714.6 Deadlines for submission... past activities (production of Schedule 3 chemicals during the previous calendar year); (b)...

  18. Intelligent perturbation algorithms for space scheduling optimization

    NASA Technical Reports Server (NTRS)

    Kurtzman, Clifford R.

    1991-01-01

    Intelligent perturbation algorithms for space scheduling optimization are presented in the form of the viewgraphs. The following subject areas are covered: optimization of planning, scheduling, and manifesting; searching a discrete configuration space; heuristic algorithms used for optimization; use of heuristic methods on a sample scheduling problem; intelligent perturbation algorithms are iterative refinement techniques; properties of a good iterative search operator; dispatching examples of intelligent perturbation algorithm and perturbation operator attributes; scheduling implementations using intelligent perturbation algorithms; major advances in scheduling capabilities; the prototype ISF (industrial Space Facility) experiment scheduler; optimized schedule (max revenue); multi-variable optimization; Space Station design reference mission scheduling; ISF-TDRSS command scheduling demonstration; and example task - communications check.

  19. Radiosensitizing Properties of Bortezomib Depend on Therapeutic Schedule

    SciTech Connect

    Labussiere, Marianne; Pinel, Sophie; Vandamme, Marc; Plenat, Francois; Chastagner, Pascal

    2011-03-01

    Purpose: To investigate the influence of the bortezomib (BTZ) on malignant glioma radiosensitivity in two xenograft models. Methods and Materials: For TCG3 and U87 models, we evaluated the antitumor activity of BTZ, radiotherapy, and BTZ plus radiothearapy according to two therapeutic schedules: a 'nonfractionated' schedule corresponding to a single dose of treatment per week, and a 'fractionated' schedule corresponding to the same weekly dose divided into 5 fractions. Treatments influence on proliferation and apoptosis indexes, cell cycle distribution, and nuclear factor-{kappa}B pathway were explored. Results: The radiosensitizing properties of BTZ observed with the nonfractionated schedule were lost with the fractionated schedule. Bortezomib-mediated radiosensitization was associated with an increased apoptosis response and major changes in cell proliferation, but the nuclear factor-{kappa}B pathway was not involved. Most of the cellular effects induced by BTZ when tumors received a single irradiation were cancelled out if radiotherapy was fractionated. Conclusion: The influence of BTZ on glioma radiosensitivity seems to depend on the treatment fractionation schedule, emphasizing the need to clarify the mechanisms underlying BTZ's radiosensitizing effects before further clinical trials are initiated.

  20. 1996 Wholesale Power and Transmission Rate Schedules.

    SciTech Connect

    United States. Bonneville Power Administration.

    1996-10-01

    Bonneville Power Administration`s (BPA) 1996 Wholesale Power Rate Schedules, 1996 Ancillary Products and Services Rate Schedule, 1996 Transmission Rate Schedules, and General Rate Schedule Provisions, contained herein, were approved on an interim basis effective October 1, 1996. These rate schedules and provisions were approved by the Federal Energy Regulatory Commission (FERC), United States Department of Energy, in September 1996 (Docket Nos EF96-2011-000 and EF96f-2021-000). These rate schedules and General Rate Schedule Provisions were approved on a final basis by the FERC July 30, 1997, in Dept. of Energy--Bonneville Power Administration, Docket Nos. EF96-2011-000 and EF96-2021-000. Except as noted elsewhere, these 1996 rate schedules and provisions supersede BPA`s Wholesale Power Rate Schedules and General Rate Schedule Provisions, and Transmission Rate Schedules and General Transmission Rate Schedule Provisions, effective October 1, 1995. These rate schedules and general rate schedule provisions include all errata.

  1. Magnetohydrodynamics MHD Engineering Test Facility ETF 200 MWe power plant. Conceptual Design Engineering Report CDER. Volume 3: Costs and schedules

    NASA Technical Reports Server (NTRS)

    1981-01-01

    The estimated plant capital cost for a coal fired 200 MWE electric generating plant with open cycle magnetohydrodynamics is divided into principal accounts based on Federal Energy Regulatory Commision account structure. Each principal account is defined and its estimated cost subdivided into identifiable and major equipment systems. The cost data sources for compiling the estimates, cost parameters, allotments, assumptions, and contingencies, are discussed. Uncertainties associated with developing the costs are quantified to show the confidence level acquired. Guidelines established in preparing the estimated costs are included. Based on an overall milestone schedule related to conventional power plant scheduling experience and starting procurement of MHD components during the preliminary design phase there is a 6 1/2-year construction period. The duration of the project from start to commercial operation is 79 months. The engineering phase of the project is 4 1/2 years; the construction duration following the start of the man power block is 37 months.

  2. User requirements for a patient scheduling system

    NASA Technical Reports Server (NTRS)

    Zimmerman, W.

    1979-01-01

    A rehabilitation institute's needs and wants from a scheduling system were established by (1) studying the existing scheduling system and the variables that affect patient scheduling, (2) conducting a human-factors study to establish the human interfaces that affect patients' meeting prescribed therapy schedules, and (3) developing and administering a questionnaire to the staff which pertains to the various interface problems in order to identify staff requirements to minimize scheduling problems and other factors that may limit the effectiveness of any new scheduling system.

  3. Environmental surveillance master sampling schedule

    SciTech Connect

    Bisping, L.E.

    1996-02-01

    Environmental surveillance of the Hanford Site and surrounding areas is conducted by the Pacific Northwest National Laboratory (PNNL) for the US Department of Energy (DOE). This document contains the planned 1996 schedules for routine collection of samples for the Surface Environmental Surveillance Project (SESP), Drinking Water Project, and Ground-Water Surveillance Project.

  4. Block Scheduling: Three Years Later.

    ERIC Educational Resources Information Center

    Corley, Edward L.

    This is a followup study of teacher perceptions regarding block scheduling. The original study was done in 1996 at a small city high school in a predominantly rural county in Ohio. At that time, lack of communication was found to be the central theme in the resistance that emerged. This paper is based on data from written responses to open-ended…

  5. A scheduling model for astronomy

    NASA Astrophysics Data System (ADS)

    Solar, M.; Michelon, P.; Avarias, J.; Garces, M.

    2016-04-01

    Astronomical scheduling problem has several external conditions that change dynamically at any time during observations, like weather condition (humidity, temperature, wind speed, opacity, etc.), and target visibility conditions (target over the horizon, Sun/Moon blocking the target). Therefore, a dynamic re-scheduling is needed. An astronomical project will be scheduled as one or more Scheduling Blocks (SBs) as an atomic unit of astronomical observations. We propose a mixed integer linear programming (MILP) solution to select the best SBs, favors SBs with high scientific values, and thus maximizing the quantity of completed observation projects. The data content of Atacama Large Millimeter/Submillimeter Array (ALMA) projects of cycle 0 and cycle 1 were analyzed, and a synthetic set of tests of the real instances was created. Two configurations, one of 5000 SBs in a 3 months season and another 10,000 SBs a 6 months season were created. These instances were evaluated with excellent results. Through the testing it is showed that the MILP proposal has optimal solutions.

  6. 1.2.1.1 Harvest, Collection and Storage Quarter 3 Milestone Report

    SciTech Connect

    Lynn M Wendt; William A Smith; Kara G Cafferty; Ian J Bonner; Qiyang Huang; Rachel D Colby

    2014-07-01

    Single pass baling of corn stover is required in order to meet targets for the herbaceous biomass 2017 logistics design case. Single-pass pass stover harvest is based on the grain harvest and generally results in stover with a moisture content of 30-50% wet basis (w.b). Aerobic storage of corn stover with high moisture results in high levels of dry matter loss (DML), up to 25%. Anaerobic storage (ensiling) reduces DML to less than 5%, but additional costs are associated with handling and transporting the extra moisture in the biomass. This milestone provides a best-estimate of costs for using high moisture feedstock within the conventional baled logistics system. The costs of three (3) anaerobic storage systems that reduce dry matter losses (bale wrap, silage tube, and silage drive over pile) are detailed in this milestone and compared to both a conventional dry-baled corn stover case and a high moisture bale case, both stored aerobically. The total logistics cost (harvest, collection, storage, and transportation) of the scenarios are as follows: the conventional multi-pass dry bale case and the single-pass high moisture case stored aerobically were nearly equivalent at $61.15 and $61.24/DMT. The single-pass bale wrap case was the lowest at $57.63/DMT. The bulk anaerobic cases were the most expensive at $84.33 for the silage tube case and $75.97 for the drive over pile, which reflect the additional expense of transporting high-moisture bulk material; however, a reduction in preprocessing costs may occur because these feedstocks are size reduced in the field. In summary, the costs estimates presented in this milestone report can be used to determine if anaerobic storage of high-moisture corn stover is an economical option for dry matter preservation.

  7. ROSAT telecommand scheduling

    NASA Astrophysics Data System (ADS)

    James, P. C.; Lunn, I. D. S.

    1991-07-01

    The real-time ROSAT Command System (RCS) based on the Core Command System developed for the German Space Operations Center (GSOC) are described since the launch on June 1, 1990. The off-line processing software intended to automate parts of the chain of telecommand generation have been developed to handle spacecraft control information derived from other automated systems, which include the ROSAT Mission Timeline Generator (RMTG) and the ROSAT Management of Attitude and Control System. The implementation of the interfaces between the individual RCS programs as text files organized according to a common language standard promotes visibility and ease of use. The introduction of a graphical user interface has improved the speed and efficiency of performing the tasks by an operator. Automation of both the closure of the Telecommand transport control loop and the precontact preparation activities has contributed significantly to a reduction of the spacecraft operator's workload.

  8. Diffuse lung uptake of Ga-67 citrate in treated lymphoma: Another milestone on the road to understanding

    SciTech Connect

    Podoloff, D.A.

    1996-05-01

    There are approximately 51,000 new cases of non-Hodgkin lymphoma and 7,800 new cases of Hodgkin disease reported yearly. Combined, these diseases account for 23,000 deaths. As medical oncology advances, the probability of curing cancer will increase because of improvements in diagnostic and therapeutic interventions. Anatomic diagnostic studies such as computed tomography (CT) and magnetic resonance (MR) imaging are generally used to identify and stage lymphoma; however, when the involved nodes are of normal size, CT and MR imaging are incapable of helping to distinguish between normal nodes and those involved with either Hodgkin or non-Hodgkin lymphoma. The problem of differentiating active lymphoma from scar or necrosis in residual masses after radiation therapy and/or chemotherapy, especially in the thorax, has been well documented in the medical literature. Whether gallium imaging is useful in this situation has been the subject of controversy over the years, and there have been many important detours and milestones on the road to our understanding of the role that gallium-67 scintigraphy should play. 22 refs.

  9. How should periods without social interaction be scheduled? Children's preference for practical schedules of positive reinforcement.

    PubMed

    Luczynski, Kevin C; Hanley, Gregory P

    2014-01-01

    Several studies have shown that children prefer contingent reinforcement (CR) rather than yoked noncontingent reinforcement (NCR) when continuous reinforcement is programmed in the CR schedule. Preference has not, however, been evaluated for practical schedules that involve CR. In Study 1, we assessed 5 children's preference for obtaining social interaction via a multiple schedule (periods of fixed-ratio 1 reinforcement alternating with periods of extinction), a briefly signaled delayed reinforcement schedule, and an NCR schedule. The multiple schedule promoted the most efficient level of responding. In general, children chose to experience the multiple schedule and avoided the delay and NCR schedules, indicating that they preferred multiple schedules as the means to arrange practical schedules of social interaction. In Study 2, we evaluated potential controlling variables that influenced 1 child's preference for the multiple schedule and found that the strong positive contingency was the primary variable.

  10. Adaptive Parallel Job Scheduling with Flexible CoScheduling

    SciTech Connect

    Frachtenberg, Eitan; Feitelson, Dror; Petrini, Fabrizio; Fernandez, Juan

    2005-11-01

    Abstract—Many scientific and high-performance computing applications consist of multiple processes running on different processors that communicate frequently. Because of their synchronization needs, these applications can suffer severe performance penalties if their processes are not all coscheduled to run together. Two common approaches to coscheduling jobs are batch scheduling, wherein nodes are dedicated for the duration of the run, and gang scheduling, wherein time slicing is coordinated across processors. Both work well when jobs are load-balanced and make use of the entire parallel machine. However, these conditions are rarely met and most realistic workloads consequently suffer from both internal and external fragmentation, in which resources and processors are left idle because jobs cannot be packed with perfect efficiency. This situation leads to reduced utilization and suboptimal performance. Flexible CoScheduling (FCS) addresses this problem by monitoring each job’s computation granularity and communication pattern and scheduling jobs based on their synchronization and load-balancing requirements. In particular, jobs that do not require stringent synchronization are identified, and are not coscheduled; instead, these processes are used to reduce fragmentation. FCS has been fully implemented on top of the STORM resource manager on a 256-processor Alpha cluster and compared to batch, gang, and implicit coscheduling algorithms. This paper describes in detail the implementation of FCS and its performance evaluation with a variety of workloads, including large-scale benchmarks, scientific applications, and dynamic workloads. The experimental results show that FCS saturates at higher loads than other algorithms (up to 54 percent higher in some cases), and displays lower response times and slowdown than the other algorithms in nearly all scenarios.

  11. 40 CFR 52.825 - Compliance schedules.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... schedule. Editorial Note: For Federal Register citations affecting § 52.825, see the List of CFR Sections... variances if source(s) is on an accepted and approved compliance schedule. Note 3: City of Des...

  12. A DSN optimal spacecraft scheduling model

    NASA Technical Reports Server (NTRS)

    Webb, W. A.

    1982-01-01

    A computer model is described which uses mixed-integer linear programming to provide optimal DSN spacecraft schedules given a mission set and specified scheduling requirements. A solution technique is proposed which uses Bender's Method and a heuristic starting algorithm.

  13. Integrating protocol schedules with patients' personal calendars.

    PubMed

    Civan, Andrea; Gennari, John H; Pratt, Wanda

    2006-01-01

    We propose a new approach for integrating protocol care schedules into patients' personal calendars. This approach could provide patients with greater control over their current and future scheduling demands as they seek and receive protocol-based care. PMID:17238511

  14. Immunization Schedules for Preteens and Teens

    MedlinePlus

    ... ACIP Vaccination Recommendations Why Immunize? Vaccines: The Basics Immunization Schedules for Preteens and Teens Recommend on Facebook ... on track. View or Print a Schedule Recommended Immunizations for Preteens and Teens (7-18 years) 2016 ...

  15. 48 CFR 245.606 - Inventory schedules.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Inventory schedules. 245.606 Section 245.606 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM... Contractor Inventory 245.606 Inventory schedules....

  16. 11 CFR 9006.3 - Alphabetized schedules.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... FINANCING REPORTS AND RECORDKEEPING § 9006.3 Alphabetized schedules. If the authorized committee(s) of a candidate file a schedule of itemized receipts, disbursements, or debts and obligations pursuant to 11...

  17. Flexible Job Shop Scheduling with Multi-level Job Structures

    NASA Astrophysics Data System (ADS)

    Jang, Yang-Ja; Kim, Ki-Dong; Jang, Seong-Yong; Park, Jinwoo

    This paper deals with a scheduling problem in a flexible job shop with multi-level job structures where end products are assembled from sub-assemblies or manufactured components. For such shops MRP (Material Requirement Planning) logic is frequently used to synchronize and pace the production activities for the required parts. However, in MRP, the planning of operational-level activities is left to short term scheduling. So, we need a good scheduling algorithm to generate feasible schedules taking into account shop floor characteristics and multi-level job structures used in MRP. In this paper, we present a GA (Genetic Algorithm) solution for this complex scheduling problem based on a new gene to reflect the machine assignment, operation sequences and the levels of the operations relative to final assembly operation. The relative operation level is the control parameter that paces the completion timing of the components belonging to the same branch in the multi-level job hierarchy. We compare the genetic algorithm with several dispatching rules in terms of total tardiness and the genetic algorithm shows outstanding performance for about forty modified standard job-shop problem instances.

  18. Real-time scheduling using minimum search

    NASA Technical Reports Server (NTRS)

    Tadepalli, Prasad; Joshi, Varad

    1992-01-01

    In this paper we consider a simple model of real-time scheduling. We present a real-time scheduling system called RTS which is based on Korf's Minimin algorithm. Experimental results show that the schedule quality initially improves with the amount of look-ahead search and tapers off quickly. So it sppears that reasonably good schedules can be produced with a relatively shallow search.

  19. Developmental trajectories and milestones of lesbian, gay, and bisexual young people.

    PubMed

    Savin-Williams, Ritch C; Cohen, Kenneth M

    2015-01-01

    Lesbian, gay, and bisexual (LGB) young people experience a variety of developmental trajectories that consist of milestones, the sequence and timing of which differ across individuals. They include early feelings of being different from peers, the onset of same-sex attraction, questioning one's sexuality, first same-sex sexual experience, recognition and self-labelling, disclosure to others, first romantic relationship, and self-acceptance. The invention of 'gay youth' during the 1970s and 1980s is briefly reviewed with an emphasis on the ways in which the portrait created by early research fails to capture the developmental trajectories of millennial young people. Although some young people struggle with mental health problems as they navigate these milestones, research documents the complexity, variety, and normative nature of the vast majority of LGB young people. A growing chorus of developmental, behavioural, and social scientists now emphasize that many contemporary young people forego sexual confusion, recognize the sex or gender to which they are attracted to and love, and believe they are as mentally healthy as heterosexual young people. PMID:26555639

  20. Milestones toward Majorana-based quantum computing: Fusion rule detection and topological qubit validation

    NASA Astrophysics Data System (ADS)

    Mishmash, Ryan V.; Aasen, David; Hell, Michael; Higginbotham, Andrew; Danon, Jeroen; Leijnse, Martin; Jespersen, Thomas S.; Folk, Joshua A.; Marcus, Charles M.; Flensberg, Karsten; Alicea, Jason

    We introduce a scheme for preparation, manipulation, and readout of Majorana zero modes in semiconducting wires coated with mesoscopic superconducting islands. Our approach synthesizes recent advances in materials growth with tools commonly used in quantum-dot experiments, including gate-control of tunnel barriers and Coulomb effects, charge sensing, and charge pumping. Recently, we have outlined a sequence of relatively modest milestones which interpolate between zero-mode detection and longer term quantum computing applications. In this talk, I will discuss two of these milestones: (1) detection of fusion rules for non-Abelian anyons using either proximal charge sensing or Majorana-mediated charge pumping and (2) validation of a prototype topological qubit via unconventional scaling relations between the time-averaged qubit splitting and its decoherence times T1 and T2. Both of these proposed experiments require only a single wire with two islands--a hardware configuration already available in the laboratory. Furthermore, these pre-braiding experiments can be adapted to other manipulation and readout schemes as well.

  1. Early Events in Helix Unfolding Under External Forces: A Milestoning Analysis

    PubMed Central

    Kreuzer, Steven M; Elber, Ron; Moon, Tess J

    2012-01-01

    Initial events of helix breakage as a function of load are considered using Molecular Dynamics simulations and Milestoning analysis. A helix length of ~100 amino acids is considered as a model for typical helices found in molecular machines and as a model that minimizes end effects for early events of unfolding. Transitions of individual amino acids (averaged over the helix’s interior residues) are examined and its surrounding hydrogen bonds are considered. Dense kinetic networks are constructed that, with Milestoning analysis, provide the overall kinetics of early breakage events. Network analysis and selection of MaxFlux pathways illustrate that load impacts unfolding mechanisms in addition to time scales. At relatively high (100pN) load levels, the principal intermediate is the 310-helix, while at relatively low (10pN) levels the π-helix is significantly populated, albeit not as an unfolding intermediate. Coarse variables are examined at different levels of resolution; the rate of unfolding illustrates remarkable stability under changes in the coarsening. Consistent prediction of about ~5ns for the time of a single amino-acid unfolding event are obtained. Hydrogen bonds are much faster coarse variables (by about 2 orders of magnitude) compared to backbone torsional transition, which gates unfolding and thereby provides the appropriate coarse variable for the initiation of unfolding. PMID:22471347

  2. Williston basin. Milestone test renews interest in Red Wing Creek field's meteor crater

    SciTech Connect

    Rountree, R.

    1983-04-01

    New drilling in the vicinity of Red Wing Creek field in McKenzie County, North Dakota has renewed interest in an area that has intrigued geologists for a number of years. Red Wing Creek was discovered in 1972 by True Oil Co. and has demonstrated better per-acre oil recovery than any other oil field in the Williston Basin. Fully developed several years ago, the field produces from what has been described as the central peak of an astrobleme, within a meteor crater. The current test by Milestone Petroleum Inc. is permitted to 14,200 ft and is being drilled on the rim of the crater, in SW SW 35-148n-101w, approx. a mile south of Red Wing production. The primary objective is the Ordovician Red River; but plans call for drilling deeper, through the Winnipeg, to below the Mississippian sediments that produce at Red Wing Creek field. At least 3 unsuccessful Red River tests have been drilled in or near the field in earlier years, but not in the area where Milestone is drilling. Production at Red Wing has come from porosity zones in a Mississippian oil column that measured 2600 ft in the original well; the better wells are in the heart of the field, on a rebound cone in the center of the crater.

  3. Development and testing of single-shell tank waste retrieval technologies: Milestone M-45-01 summary report

    SciTech Connect

    Shen, E.J.

    1994-08-01

    This report summarizes the activities undertaken to develop single-shell tank (SST) waste retrieval technology and complete scale-model testing. Completion of these activities fulfills the commitment of Milestone M-45-01 of the Hanford Federal Facility Agreement and Consent Order (the Tri-Party Agreement). Initial activities included engineering studies that compiled and evaluated data on all known retrieval technologies. Based on selection criteria incorporating regulatory, safety, and operational issues, several technologies were selected for further evaluation and testing. The testing ranged from small-scale, bench-top evaluations of individual technologies to full-scale integrated tests of multiple subsystems operating concurrently as a system using simulated wastes. The current baseline retrieval method for SSTs is hydraulic sluicing. This method has been used successfully in the past to recover waste from SSTs. Variations of this hydraulic or ``past practice`` sluicing may be used to retrieve the waste from the majority of the SSTs. To minimize the potential for releases to the soil, arm-based retrieval systems may be used to recover waste from tanks that are known or suspected to have leaked. Both hydraulic sluicing and arm-based retrieval will be demonstrated in the first SST. Hydraulic sluicing is expected to retrieve most of the waste, and arm-based retrieval will retrieve wastes that remain after sluicing. Subsequent tanks will be retrieved by either hydraulic sluicing or arm-based methods, but not both. The method will be determined by waste characterization, tank integrity (leak status), and presence of in-tank hardware. Currently, it is assumed that approximately 75% of all SSTs will be retrieved by hydraulic sluicing and the remaining tanks by arm-based methods.

  4. 40 CFR 141.702 - Sampling schedules.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 24 2013-07-01 2013-07-01 false Sampling schedules. 141.702 Section... Monitoring Requirements § 141.702 Sampling schedules. (a) Systems required to conduct source water monitoring under § 141.701 must submit a sampling schedule that specifies the calendar dates when the system...

  5. 9 CFR 390.6 - Fee schedule.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Fee schedule. 390.6 Section 390.6 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE FOOD SAFETY AND... schedule. Department regulations provide for a schedule of reasonable standard charges for document...

  6. 77 FR 41258 - FOIA Fee Schedule Update

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-13

    ... Proposed FOIA Fee Schedule, 77 FR 32433. No comments were received in response to that notice, and the... Schedule Update went into effect on July 29, 2011. 76 FR 43819. Board Action Accordingly, the Board issues... SAFETY BOARD 10 CFR Part 1703 FOIA Fee Schedule Update AGENCY: Defense Nuclear Facilities Safety...

  7. 21 CFR 1308.49 - Emergency scheduling.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Emergency scheduling. 1308.49 Section 1308.49 Food and Drugs DRUG ENFORCEMENT ADMINISTRATION, DEPARTMENT OF JUSTICE SCHEDULES OF CONTROLLED SUBSTANCES Hearings § 1308.49 Emergency scheduling. Pursuant to 21 U.S.C. 811(h) and without regard to...

  8. 19 CFR 122.63 - Scheduled airlines.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 1 2014-04-01 2014-04-01 false Scheduled airlines. 122.63 Section 122.63 Customs... AIR COMMERCE REGULATIONS Clearance of Aircraft and Permission To Depart § 122.63 Scheduled airlines... scheduled airlines covered by this subpart. (a) Clearance at other than airport of final departure....

  9. 19 CFR 122.63 - Scheduled airlines.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 1 2011-04-01 2011-04-01 false Scheduled airlines. 122.63 Section 122.63 Customs... AIR COMMERCE REGULATIONS Clearance of Aircraft and Permission To Depart § 122.63 Scheduled airlines... scheduled airlines covered by this subpart. (a) Clearance at other than airport of final departure....

  10. 19 CFR 122.63 - Scheduled airlines.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Scheduled airlines. 122.63 Section 122.63 Customs... AIR COMMERCE REGULATIONS Clearance of Aircraft and Permission To Depart § 122.63 Scheduled airlines... scheduled airlines covered by this subpart. (a) Clearance at other than airport of final departure....

  11. 19 CFR 122.63 - Scheduled airlines.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 1 2012-04-01 2012-04-01 false Scheduled airlines. 122.63 Section 122.63 Customs... AIR COMMERCE REGULATIONS Clearance of Aircraft and Permission To Depart § 122.63 Scheduled airlines... scheduled airlines covered by this subpart. (a) Clearance at other than airport of final departure....

  12. 19 CFR 122.63 - Scheduled airlines.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 1 2013-04-01 2013-04-01 false Scheduled airlines. 122.63 Section 122.63 Customs... AIR COMMERCE REGULATIONS Clearance of Aircraft and Permission To Depart § 122.63 Scheduled airlines... scheduled airlines covered by this subpart. (a) Clearance at other than airport of final departure....

  13. Response Strength in Extreme Multiple Schedules

    ERIC Educational Resources Information Center

    McLean, Anthony P.; Grace, Randolph C.; Nevin, John A.

    2012-01-01

    Four pigeons were trained in a series of two-component multiple schedules. Reinforcers were scheduled with random-interval schedules. The ratio of arranged reinforcer rates in the two components was varied over 4 log units, a much wider range than previously studied. When performance appeared stable, prefeeding tests were conducted to assess…

  14. Fast Randomized STDMA Link Scheduling

    NASA Astrophysics Data System (ADS)

    Gomez, Sergio; Gras, Oriol; Friderikos, Vasilis

    In this paper a fast randomized parallel link swap based packing (RSP) algorithm for timeslot allocation in a spatial time division multiple access (STDMA) wireless mesh network is presented. The proposed randomized algorithm extends several greedy scheduling algorithms that utilize the physical interference model by applying a local search that leads to a substantial improvement in the spatial timeslot reuse. Numerical simulations reveal that compared to previously scheduling schemes the proposed randomized algorithm can achieve a performance gain of up to 11%. A significant benefit of the proposed scheme is that the computations can be parallelized and therefore can efficiently utilize commoditized and emerging multi-core and/or multi-CPU processors.

  15. 49 CFR Schedule C to Subpart B of... - Schedule C to Subpart B of Part 1139

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 8 2014-10-01 2014-10-01 false Schedule C to Subpart B of Part 1139 C Schedule C... REVENUE PROCEEDINGS Intercity Bus Industry Pt. 1139, Subpt. B, Sch. C Schedule C to Subpart B of Part 1139 Attachment 1 Schedule C Part I—Condensed Income Statement () Greyhound Lines, Inc.()Trailways combined()...

  16. 49 CFR Schedule C to Subpart B of... - Schedule C to Subpart B of Part 1139

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 8 2010-10-01 2010-10-01 false Schedule C to Subpart B of Part 1139 C Schedule C... REVENUE PROCEEDINGS Intercity Bus Industry Pt. 1139, Subpt. B, Sch. C Schedule C to Subpart B of Part 1139 Attachment 1 Schedule C Part I—Condensed Income Statement () Greyhound Lines, Inc.()Trailways combined()...

  17. 29 CFR 825.203 - Scheduling of intermittent or reduced schedule leave.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... OF LABOR OTHER LAWS THE FAMILY AND MEDICAL LEAVE ACT OF 1993 Employee Leave Entitlements Under the Family and Medical Leave Act § 825.203 Scheduling of intermittent or reduced schedule leave. Eligible... 29 Labor 3 2014-07-01 2014-07-01 false Scheduling of intermittent or reduced schedule......

  18. 29 CFR 825.203 - Scheduling of intermittent or reduced schedule leave.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... OF LABOR OTHER LAWS THE FAMILY AND MEDICAL LEAVE ACT OF 1993 Employee Leave Entitlements Under the Family and Medical Leave Act § 825.203 Scheduling of intermittent or reduced schedule leave. Eligible... 29 Labor 3 2010-07-01 2010-07-01 false Scheduling of intermittent or reduced schedule......

  19. 29 CFR 825.203 - Scheduling of intermittent or reduced schedule leave.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... OF LABOR OTHER LAWS THE FAMILY AND MEDICAL LEAVE ACT OF 1993 Employee Leave Entitlements Under the Family and Medical Leave Act § 825.203 Scheduling of intermittent or reduced schedule leave. Eligible... 29 Labor 3 2012-07-01 2012-07-01 false Scheduling of intermittent or reduced schedule......

  20. 29 CFR 825.203 - Scheduling of intermittent or reduced schedule leave.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... OF LABOR OTHER LAWS THE FAMILY AND MEDICAL LEAVE ACT OF 1993 Employee Leave Entitlements Under the Family and Medical Leave Act § 825.203 Scheduling of intermittent or reduced schedule leave. Eligible... 29 Labor 3 2013-07-01 2013-07-01 false Scheduling of intermittent or reduced schedule......

  1. 29 CFR 825.203 - Scheduling of intermittent or reduced schedule leave.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... OF LABOR OTHER LAWS THE FAMILY AND MEDICAL LEAVE ACT OF 1993 Employee Leave Entitlements Under the Family and Medical Leave Act § 825.203 Scheduling of intermittent or reduced schedule leave. Eligible... 29 Labor 3 2011-07-01 2011-07-01 false Scheduling of intermittent or reduced schedule......

  2. Environmental surveillance master sampling schedule

    SciTech Connect

    Bisping, L.E.

    1993-01-01

    Environmental surveillance of the Hanford Site and surrounding areas is conducted by the Pacific Northwest Laboratory (PNL) for the US Department of Energy (DOE). Samples are routinely collected and analyzed to determine the quality of air, surface water, ground water, soil, sediment, wildlife, vegetation, foodstuffs, and farm products at Hanford Site and surrounding communities. This document contains the planned schedule for routine sample collection for the Surface Environmental Surveillance Project (SESP) and Drinking Water Project, and Ground-Water Surveillance Project.

  3. Environmental surveillance master sampling schedule

    SciTech Connect

    Bisping, L.E.

    1995-02-01

    Environmental surveillance of the Hanford Site and surrounding areas is conducted by the Pacific Northwest Laboratory (PNL) for the U.S. Department of Energy (DOE). This document contains the planned 1994 schedules for routine collection of samples for the Surface Environmental Surveillance Project (SESP), Drinking Water Project, and Ground-Water Surveillance Project. Samples are routinely collected for the SESP and analyzed to determine the quality of air, surface water, soil, sediment, wildlife, vegetation, foodstuffs, and farm products at Hanford Site and surrounding communities. The responsibility for monitoring onsite drinking water falls outside the scope of the SESP. PNL conducts the drinking water monitoring project concurrent with the SESP to promote efficiency and consistency, utilize expertise developed over the years, and reduce costs associated with management, procedure development, data management, quality control, and reporting. The ground-water sampling schedule identifies ground-water sampling .events used by PNL for environmental surveillance of the Hanford Site. Sampling is indicated as annual, semi-annual, quarterly, or monthly in the sampling schedule. Some samples are collected and analyzed as part of ground-water monitoring and characterization programs at Hanford (e.g. Resources Conservation and Recovery Act (RCRA), Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA), or Operational). The number of samples planned by other programs are identified in the sampling schedule by a number in the analysis column and a project designation in the Cosample column. Well sampling events may be merged to avoid redundancy in cases where sampling is planned by both-environmental surveillance and another program.

  4. Intelsat satellite scheduled for launch

    NASA Technical Reports Server (NTRS)

    1981-01-01

    The launch schedule for Intelsat 5-B, the prime Intelsat satellite to provide communications services between the Americas, Europe, the Middle East, and Africa, is presented. The planned placement of the satellite into an elliptical transfer orbit, and circularization of the orbit at geosynchronous altitude over the equator are described. Characteristics of the Atlas Centaur launch vehicle, AC-56, are given. The launch operation is summarized and the launch sequence presented. The Intelsat team and contractors are listed.

  5. Scheduled Peripheral Component Interconnect Arbiter

    NASA Technical Reports Server (NTRS)

    Nixon, Scott Alan (Inventor)

    2015-01-01

    Systems and methods are described for arbitrating access of a communication bus. In one embodiment, a method includes performing steps on one or more processors. The steps include: receiving an access request from a device of the communication bus; evaluating a bus schedule to determine an importance of the device based on the access request; and selectively granting access of the communication bus to the device based on the importance of the device.

  6. Obtaining schedules for digital systems

    NASA Technical Reports Server (NTRS)

    Jagadish, H. V.; Kailath, Thomas

    1991-01-01

    A systematic technique is presented to derive correct schedules for a synchronous digital system, given a signal flow graph for an algorithm. It is also shown how to use this technique to derive designs that are optimal in having the lowest latency, the highest throughput, or the smallest number of registers. The same technique can also be used to verify digital systems that have already been designed.

  7. Schedules of Controlled Substances: Placement of Three Synthetic Phenethylamines Into Schedule I. Final rule.

    PubMed

    2016-09-27

    With the issuance of this final rule, the Administrator of the Drug Enforcement Administration places three synthetic phenethylamines: 2-(4-iodo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine (25I-NBOMe; 2C-I-NBOMe; 25I; Cimbi-5), 2-(4-chloro-2,5-dimethoxyphenyl)-N- (2-methoxybenzyl)ethanamine (25C-NBOMe; 2C-C-NBOMe; 25C; Cimbi-82), and 2-(4-bromo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine (25B- NBOMe; 2C-B-NBOMe; 25B; Cimbi-36), including their optical, positional, and geometric isomers, salts and salts of isomers, whenever the existence of such salts, isomers, and salts of isomers is possible, into schedule I of the Controlled Substances Act. This scheduling action is pursuant to the Controlled Substances Act which requires that such actions be made on the record after opportunity for a hearing through formal rulemaking. This action continues the application of the regulatory controls and administrative, civil, and criminal sanctions applicable to schedule I controlled substances on persons who handle (manufacture, distribute, reverse distribute, import, export, engage in research, conduct instructional activities or chemical analysis, or possess), or propose to handle 25I-NBOMe, 25C-NBOMe, or 25B-NBOMe.

  8. Ada and cyclic runtime scheduling

    NASA Technical Reports Server (NTRS)

    Hood, Philip E.

    1986-01-01

    An important issue that must be faced while introducing Ada into the real time world is efficient and prodictable runtime behavior. One of the most effective methods employed during the traditional design of a real time system is the cyclic executive. The role cyclic scheduling might play in an Ada application in terms of currently available implementations and in terms of implementations that might be developed especially to support real time system development is examined. The cyclic executive solves many of the problems faced by real time designers, resulting in a system for which it is relatively easy to achieve approporiate timing behavior. Unfortunately a cyclic executive carries with it a very high maintenance penalty over the lifetime of the software that is schedules. Additionally, these cyclic systems tend to be quite fragil when any aspect of the system changes. The findings are presented of an ongoing SofTech investigation into Ada methods for real time system development. The topics covered include a description of the costs involved in using cyclic schedulers, the sources of these costs, and measures for future systems to avoid these costs without giving up the runtime performance of a cyclic system.

  9. Balancing antagonistic time and resource utilization constraints in over-subscribed scheduling problems

    NASA Technical Reports Server (NTRS)

    Smith, Stephen F.; Pathak, Dhiraj K.

    1991-01-01

    In this paper, we report work aimed at applying concepts of constraint-based problem structuring and multi-perspective scheduling to an over-subscribed scheduling problem. Previous research has demonstrated the utility of these concepts as a means for effectively balancing conflicting objectives in constraint-relaxable scheduling problems, and our goal here is to provide evidence of their similar potential in the context of HST observation scheduling. To this end, we define and experimentally assess the performance of two time-bounded heuristic scheduling strategies in balancing the tradeoff between resource setup time minimization and satisfaction of absolute time constraints. The first strategy considered is motivated by dispatch-based manufacturing scheduling research, and employs a problem decomposition that concentrates local search on minimizing resource idle time due to setup activities. The second is motivated by research in opportunistic scheduling and advocates a problem decomposition that focuses attention on the goal activities that have the tightest temporal constraints. Analysis of experimental results gives evidence of differential superiority on the part of each strategy in different problem solving circumstances. A composite strategy based on recognition of characteristics of the current problem solving state is then defined and tested to illustrate the potential benefits of constraint-based problem structuring and multi-perspective scheduling in over-subscribe scheduling problems.

  10. 36 CFR 1225.12 - How are records schedules developed?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false How are records schedules developed? 1225.12 Section 1225.12 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS... or work process analysis to identify the functions or activities performed by each organization...

  11. Scheduler Design Criteria: Requirements and Considerations

    NASA Technical Reports Server (NTRS)

    Lee, Hanbong

    2016-01-01

    This presentation covers fundamental requirements and considerations for developing schedulers in airport operations. We first introduce performance and functional requirements for airport surface schedulers. Among various optimization problems in airport operations, we focus on airport surface scheduling problem, including runway and taxiway operations. We then describe a basic methodology for airport surface scheduling such as node-link network model and scheduling algorithms previously developed. Next, we explain how to design a mathematical formulation in more details, which consists of objectives, decision variables, and constraints. Lastly, we review other considerations, including optimization tools, computational performance, and performance metrics for evaluation.

  12. Is There a Downside to Schedule Control for the Work-Family Interface?

    ERIC Educational Resources Information Center

    Schieman, Scott; Young, Marisa

    2010-01-01

    Using data from a 2007 U.S. survey of workers, this article examines the implications of schedule control for work-family role blurring and work-family conflict. Four main findings indicate that (a) schedule control is associated with more frequent working at home and work-family multitasking activities; (b) the positive association between…

  13. Prisoners of Time: Implementing a Block Schedule in the High School.

    ERIC Educational Resources Information Center

    Mistretta, Gerald M.; Polansky, Harvey B.

    1997-01-01

    A committee comprised of six veteran teachers, the principal, and one parent initiated East Lyme (Connecticut) High School's search for a workable school schedule. The alternative-day block schedule featured semester and full-year course formats, 85-minute time blocks, a 45-minute lunch/club/activity period, and a closed campus. A survey found…

  14. The Over-Scheduling Myth. Research-to-Results Brief. Publication #2008-12

    ERIC Educational Resources Information Center

    Mahoney, Joseph L.; Harris, Angel L.; Eccles, Jacquelynne S.

    2008-01-01

    Contrary to popular hypothesis, recent research rejects the notion that most or even many children and youth are over-scheduled and are suffering as a result. In fact, less than one in ten could be described as over-scheduled. Moreover, research indicates that only six in ten children and youth participate in organized out-of-school activities at…

  15. 15 CFR 714.3 - Advance declaration requirements for additionally planned production of Schedule 3 chemicals.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... additionally planned production of Schedule 3 chemicals. 714.3 Section 714.3 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ACTIVITIES INVOLVING SCHEDULE 3 CHEMICALS § 714.3...

  16. 15 CFR 714.3 - Advance declaration requirements for additionally planned production of Schedule 3 chemicals.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... additionally planned production of Schedule 3 chemicals. 714.3 Section 714.3 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ACTIVITIES INVOLVING SCHEDULE 3 CHEMICALS § 714.3...

  17. 15 CFR 713.7 - Deadlines for submission of Schedule 2 declarations, reports, and amendments.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ACTIVITIES INVOLVING SCHEDULE 2 CHEMICALS § 713.7 Deadlines for submission... (production, processing, or consumption of Schedule 2 chemicals during the previous calendar year); (b)...

  18. 15 CFR 713.7 - Deadlines for submission of Schedule 2 declarations, reports, and amendments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ACTIVITIES INVOLVING SCHEDULE 2 CHEMICALS § 713.7 Deadlines for submission... (production, processing, or consumption of Schedule 2 chemicals during the previous calendar year); (b)...

  19. 15 CFR 714.3 - Advance declaration requirements for additionally planned production of Schedule 3 chemicals.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... additionally planned production of Schedule 3 chemicals. 714.3 Section 714.3 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ACTIVITIES INVOLVING SCHEDULE 3 CHEMICALS § 714.3...

  20. 15 CFR 713.7 - Deadlines for submission of Schedule 2 declarations, reports, and amendments.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ACTIVITIES INVOLVING SCHEDULE 2 CHEMICALS § 713.7 Deadlines for submission... (production, processing, or consumption of Schedule 2 chemicals during the previous calendar year); (b)...