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Sample records for ada technologies holds

  1. Ada (R) assessment: An important issue within European Columbus Support Technology Programme

    NASA Technical Reports Server (NTRS)

    Vielcanet, P.

    1986-01-01

    Software will be more important and more critical for Columbus than for any ESA previous project. As a simple comparison, overall software size has been in the range of 100 K source statements for EXOSAT, 500 K for Spacelab, and will probably reach several million lines of code for Columbus (all element together). Based on past experience, the total development cost of software can account for about 10 pct to 15 pct of the total space project development cost. The Ada technology may support the strong software engineering principles needed for Columbus, provided that technology is sufficiently mature and industry plans are meeting the Columbus project schedule. Over the past 3 years, Informatique Internationale has conducted a coherent program based on Ada technology assessment studies and experiments, for ESA and CNES. This specific research and development program benefits from 15 years experience in the field of space software development and is supported by the overall software engineering expertise of the company. The assessment and experiments of Ada software engineering by Informatique Internationale are detailed.

  2. GSFC Ada programming guidelines

    NASA Technical Reports Server (NTRS)

    Roy, Daniel M.; Nelson, Robert W.

    1986-01-01

    A significant Ada effort has been under way at Goddard for the last two years. To ease the center's transition toward Ada (notably for future space station projects), a cooperative effort of half a dozen companies and NASA personnel was started in 1985 to produce programming standards and guidelines for the Ada language. The great richness of the Ada language and the need of programmers for good style examples makes Ada programming guidelines an important tool to smooth the Ada transition. Because of the natural divergence of technical opinions, the great diversity of our government and private organizations and the novelty of the Ada technology, the creation of an Ada programming guidelines document is a difficult and time consuming task. It is also a vital one. Steps must now be taken to ensure that the guide is refined in an organized but timely manner to reflect the growing level of expertise of the Ada community.

  3. Annotated Ada 95 Reference Manual.

    DTIC Science & Technology

    1994-12-21

    A. Strohmeier (Swiss Fed Inst of Technology: Switzerland); W. Taylor (consultant: UK); J. Tokar ( Tartan ); E. Vasilescu (Grumman); J. Vladik...Language Preci- 69 sion Team (Odyssey Research Associates), the Ada 9X User/Implementer Teams (AETECH, Tartan , TeleSoft), the Ada 9X Implementation...the RM83. [Ada Issue (AI)) (All An Ada Issue (AT) is a numbered ruling from the ARG. {Ada Commentary Integration Document ( ACID )) ( ACID ) The Ada

  4. Evolution of Ada technology in the flight dynamics area: Implementation/testing phase analysis

    NASA Technical Reports Server (NTRS)

    Quimby, Kelvin L.; Esker, Linda; Miller, John; Smith, Laurie; Stark, Mike; Mcgarry, Frank

    1989-01-01

    An analysis is presented of the software engineering issues related to the use of Ada for the implementation and system testing phases of four Ada projects developed in the flight dynamics area. These projects reflect an evolving understanding of more effective use of Ada features. In addition, the testing methodology used on these projects has changed substantially from that used on previous FORTRAN projects.

  5. Evolution of Ada technology in the flight dynamics area: Design phase analysis

    NASA Technical Reports Server (NTRS)

    Quimby, Kelvin L.; Esker, Linda

    1988-01-01

    The software engineering issues related to the use of the Ada programming language during the design phase of an Ada project are analyzed. Discussion shows how an evolving understanding of these issues is reflected in the design processes of three generations of Ada projects.

  6. ART-Ada: An Ada-based expert system tool

    NASA Technical Reports Server (NTRS)

    Lee, S. Daniel; Allen, Bradley P.

    1990-01-01

    The Department of Defense mandate to standardize on Ada as the language for software systems development has resulted in an increased interest in making expert systems technology readily available in Ada environments. NASA's Space Station Freedom is an example of the large Ada software development projects that will require expert systems in the 1990's. Another large scale application that can benefit from Ada based expert system tool technology is the Pilot's Associate (PA) expert system project for military combat aircraft. The Automated Reasoning Tool-Ada (ART-Ada), an Ada expert system tool, is explained. ART-Ada allows applications of a C-based expert system tool called ART-IM to be deployed in various Ada environments. ART-Ada is being used to implement several prototype expert systems for NASA's Space Station Freedom program and the U.S. Air Force.

  7. ART-Ada: An Ada-based expert system tool

    NASA Technical Reports Server (NTRS)

    Lee, S. Daniel; Allen, Bradley P.

    1991-01-01

    The Department of Defense mandate to standardize on Ada as the language for software systems development has resulted in increased interest in making expert systems technology readily available in Ada environments. NASA's Space Station Freedom is an example of the large Ada software development projects that will require expert systems in the 1990's. Another large scale application that can benefit from Ada based expert system tool technology is the Pilot's Associate (PA) expert system project for military combat aircraft. Automated Reasoning Tool (ART) Ada, an Ada Expert system tool is described. ART-Ada allow applications of a C-based expert system tool called ART-IM to be deployed in various Ada environments. ART-Ada is being used to implement several prototype expert systems for NASA's Space Station Freedom Program and the U.S. Air Force.

  8. ART/Ada and CLIPS/Ada

    NASA Technical Reports Server (NTRS)

    Culbert, Chris

    1990-01-01

    Although they have reached a point of commercial viability, expert systems were originally developed in artificial intelligence (AI) research environments. Many of the available tools still work best in such environments. These environments typically utilize special hardware such as LISP machines and relatively unfamiliar languages such as LISP or Prolog. Space Station applications will require deep integration of expert system technology with applications developed in conventional languages, specifically Ada. The ability to apply automation to Space Station functions could be greatly enhanced by widespread availability of state-of-the-art expert system tools based on Ada. Although there have been some efforts to examine the use of Ada for AI applications, there are few, if any, existing products which provide state-of-the-art AI capabilities in an Ada tool. The goal of the ART/Ada Design Project is to conduct research into the implementation in Ada of state-of-the-art hybrid expert systems building tools (ESBT's). This project takes the following approach: using the existing design of the ART-IM ESBT as a starting point, analyze the impact of the Ada language and Ada development methodologies on that design; redesign the system in Ada; and analyze its performance. The research project will attempt to achieve a comprehensive understanding of the potential for embedding expert systems in Ada systems for eventual application in future Space Station Freedom projects. During Phase 1 of the project, initial requirements analysis, design, and implementation of the kernel subset of ART-IM functionality was completed. During Phase 2, the effort has been focused on the implementation and performance analysis of several versions with increasing functionality. Since production quality ART/Ada tools will not be available for a considerable time, and additional subtask of this project will be the completion of an Ada version of the CLIPS expert system shell developed by NASA

  9. 78 FR 1265 - Dana Holding Corporation; Power Technologies Group Division; Including On-Site Leased Workers...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-08

    ... Employment and Training Administration Dana Holding Corporation; Power Technologies Group Division; Including... Technologies Group Division, Milwaukee, Wisconsin (subject firm). The worker group includes on-site leased... Company, Power Technologies Group Division, Milwaukee, Wisconsin, who were engaged in employment...

  10. EVALUATION OF THE ADA TECHNOLOGIES' ELECTRO-DECON PROCESS TO REMOVE RADIOLOGICAL CONTAMINATION

    SciTech Connect

    Pao, Jenn-Hai; Demmer, Rick L.; Argyle, Mark D.; Veatch, Brad D.

    2003-02-27

    A surface decontamination system featuring the use of ADA's electrochemical process was tested and evaluated. The process can be flexibly deployed by using an electrolyte delivery system that has been demonstrated to be reliable and effective. Experimental results demonstrate the effectiveness of this system for the surface decontamination of radiologically contaminated stainless steel.

  11. AdaNET executive summary

    NASA Technical Reports Server (NTRS)

    Digman, R. Michael

    1988-01-01

    The goal of AdaNET is to transfer existing and emerging software engineering technology from the Federal government to the private sector. The views and perspectives of the current project participants on long and short term goals for AdaNET; organizational structure; resources and returns; summary of identified AdaNET services; and the summary of the organizational model currently under discussion are presented.

  12. Ada COCOMO and the Ada Process Model

    DTIC Science & Technology

    1989-01-01

    language, the use of incremental development, and the use of the Ada process model capitalizing on the strengths of Ada to improve the efficiency of software...development. This paper presents the portions of the revised Ada COCOMO dealing with the effects of Ada and the Ada process model . The remainder of...this section of the paper discusses the objectives of Ada COCOMO. Section 2 describes the Ada Process Model and its overall effects on software

  13. Holding the Edge: Maintaining the Defense Technology Base

    DTIC Science & Technology

    1989-04-01

    inbreeding that results when technology base work. laboratories try to do everything in-house. The creation of corporate laboratories would Congress...technology demonstrations, and totalled $43 mil- ties, i.e., to narrow the gap between the originators lion . For fiscal year 1990, prototyping funds

  14. 77 FR 74520 - Encore Clean Energy, Inc., Energy & Engine Technology Corp., Equity Media Holdings Corporation...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-14

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION Encore Clean Energy, Inc., Energy & Engine Technology Corp., Equity Media Holdings Corporation, eTotalSource, Inc., Extensions, Inc., Firepond, Inc., and GNC Energy Corporation; Order...

  15. AdaNET research project

    NASA Technical Reports Server (NTRS)

    Digman, R. Michael

    1988-01-01

    The components necessary for the success of the commercialization of an Ada Technology Transition Network are reported in detail. The organizational plan presents the planned structure for services development and technical transition of AdaNET services to potential user communities. The Business Plan is the operational plan for the AdaNET service as a commercial venture. The Technical Plan is the plan from which the AdaNET can be designed including detailed requirements analysis. Also contained is an analysis of user fees and charges, and a proposed user fee schedule.

  16. CLIPS/Ada: An Ada-based tool for building expert systems

    NASA Technical Reports Server (NTRS)

    White, W. A.

    1990-01-01

    Clips/Ada is a production system language and a development environment. It is functionally equivalent to the CLIPS tool. CLIPS/Ada was developed in order to provide a means of incorporating expert system technology into projects where the use of the Ada language had been mandated. A secondary purpose was to glean information about the Ada language and its compilers. Specifically, whether or not the language and compilers were mature enough to support AI applications. The CLIPS/Ada tool is coded entirely in Ada and is designed to be used by Ada systems that require expert reasoning.

  17. Software reuse issues affecting AdaNET

    NASA Technical Reports Server (NTRS)

    Mcbride, John G.

    1989-01-01

    The AdaNet program is reviewing its long-term goals and strategies. A significant concern is whether current AdaNet plans adequately address the major strategic issues of software reuse technology. The major reuse issues of providing AdaNet services that should be addressed as part of future AdaNet development are identified and reviewed. Before significant development proceeds, a plan should be developed to resolve the aforementioned issues. This plan should also specify a detailed approach to develop AdaNet. A three phased strategy is recommended. The first phase would consist of requirements analysis and produce an AdaNet system requirements specification. It would consider the requirements of AdaNet in terms of mission needs, commercial realities, and administrative policies affecting development, and the experience of AdaNet and other projects promoting the transfer software engineering technology. Specifically, requirements analysis would be performed to better understand the requirements for AdaNet functions. The second phase would provide a detailed design of the system. The AdaNet should be designed with emphasis on the use of existing technology readily available to the AdaNet program. A number of reuse products are available upon which AdaNet could be based. This would significantly reduce the risk and cost of providing an AdaNet system. Once a design was developed, implementation would proceed in the third phase.

  18. Using Ada: The deeper challenges

    NASA Technical Reports Server (NTRS)

    Feinberg, David A.

    1986-01-01

    The Ada programming language and the associated Ada Programming Support Environment (APSE) and Ada Run Time Environment (ARTE) provide the potential for significant life-cycle cost reductions in computer software development and maintenance activities. The Ada programming language itself is standardized, trademarked, and controlled via formal validation procedures. Though compilers are not yet production-ready as most would desire, the technology for constructing them is sufficiently well known and understood that time and money should suffice to correct current deficiencies. The APSE and ARTE are, on the other hand, significantly newer issues within most software development and maintenance efforts. Currently, APSE and ARTE are highly dependent on differing implementer concepts, strategies, and market objectives. Complex and sophisticated mission-critical computing systems require the use of a complete Ada-based capability, not just the programming language itself; yet the range of APSE and ARTE features which must actually be utilized can vary significantly from one system to another. As a consequence, the need to understand, objectively evaluate, and select differing APSE and ARTE capabilities and features is critical to the effective use of Ada and the life-cycle efficiencies it is intended to promote. It is the selection, collection, and understanding of APSE and ARTE which provide the deeper challenges of using Ada for real-life mission-critical computing systems. Some of the current issues which must be clarified, often on a case-by-case basis, in order to successfully realize the full capabilities of Ada are discussed.

  19. Ada issues in implementing ART-Ada

    NASA Technical Reports Server (NTRS)

    Lee, S. Daniel

    1990-01-01

    Due to the Ada mandate of a number of government agencies, interest in deploying expert systems such as Ada has increased. Recently, several Ada-based expert system tools have been developed. According to a recent benchmark report, these tools do not perform as well as similar tools written in C. While poorly implemented Ada compilers contribute to the poor benchmark result, some fundamental problems of the Ada language itself have been uncovered. Here, the authors describe Ada language issues encountered during the deployment of ART-Ada, an expert system tool for Ada deployment. ART-Ada is being used to implement several prototype expert systems for the Space Station Freedom and the U.S. Air Force.

  20. 76 FR 70722 - Healthcare Technology Holdings, Inc.; Analysis of Proposed Agreement Containing Consent Orders To...

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    2011-11-15

    ... From the Federal Register Online via the Government Publishing Office FEDERAL TRADE COMMISSION Healthcare Technology Holdings, Inc.; Analysis of Proposed Agreement Containing Consent Orders To Aid Public Comment Correction In notice document 2011-28497 appearing on pages 68189-68191 in the issue of...

  1. 78 FR 57921 - Municipal Mortgage & Equity LLC, Prolink Holdings Corp., RPM Technologies, Inc., SARS Corp...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-20

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION Municipal Mortgage & Equity LLC, Prolink Holdings Corp., RPM Technologies, Inc., SARS Corp... lack of current and accurate information concerning the securities of SARS Corp. because it has...

  2. Software Technology for Adaptable, Reliable Systems (STARS). Reusability Library (RLF) AdaTAU Software User’s Manual

    DTIC Science & Technology

    1990-10-26

    210/003/00 26 October 1990 D I ELECT E 90 11. 13 113 REPORT DOCUMENTATION PAGE Form Approved 01- MB No 0704-0188 Jurtic feDC- n; nuo~’et for. of mlc-o...incorporating an integrated form of AdaTAU and AdaKNET. The manual provides a librarian system overview and provides an ann’~tateýd sample usage...various packages providing Abstract Data Types (ADTs) that form the basis for the collection of services and objects provided within AdaTAU. This rnanual

  3. Ada Implementation Guide. Software Engineering With Ada. Volume 2

    DTIC Science & Technology

    1994-04-01

    Standards and Technology ............. A-4 DON Software Executive Official ...................... A-4 DON Ada Representative...Cost Analysis ........................ A-6 Software Technology Support Center .................... A-6 Software Engineering Institute...A-7 Software Technology for Adaptable, Reliable Systems (STARS) ....................................... A-7 A.1.2 Training

  4. Ada task scheduling: A focused Ada investigation

    NASA Technical Reports Server (NTRS)

    Legrand, Sue

    1988-01-01

    The types of control that are important for real time task scheduling are discussed. Some closely related real time issues are mentioned and major committee and research activities in this area are delineated. Although there are some problems with Ada and its real time task scheduling, Ada presents fewer than any known alternative. Ada was designed for the domain of real time embedded systems, but Ada compilers may not contain a level of task scheduling support that is adequate for all real time applications. The question addressed is which implementations of Ada's task scheduling are adequate for effective real time systems for NASA applications.

  5. Transforming AdaPT to Ada

    NASA Technical Reports Server (NTRS)

    Goldsack, Stephen J.; Holzbach-Valero, A. A.; Waldrop, Raymond S.; Volz, Richard A.

    1991-01-01

    This paper describes how the main features of the proposed Ada language extensions intended to support distribution, and offered as possible solutions for Ada9X can be implemented by transformation into standard Ada83. We start by summarizing the features proposed in a paper (Gargaro et al, 1990) which constitutes the definition of the extensions. For convenience we have called the language in its modified form AdaPT which might be interpreted as Ada with partitions. These features were carefully chosen to provide support for the construction of executable modules for execution in nodes of a network of loosely coupled computers, but flexibly configurable for different network architectures and for recovery following failure, or adapting to mode changes. The intention in their design was to provide extensions which would not impact adversely on the normal use of Ada, and would fit well in style and feel with the existing standard. We begin by summarizing the features introduced in AdaPT.

  6. AdaNET research plan

    NASA Technical Reports Server (NTRS)

    Mcbride, John G.

    1990-01-01

    The mission of the AdaNET research effort is to determine how to increase the availability of reusable Ada components and associated software engineering technology to both private and Federal sectors. The effort is structured to define the requirements for transfer of Federally developed software technology, study feasible approaches to meeting the requirements, and to gain experience in applying various technologies and practices. The overall approach to the development of the AdaNET System Specification is presented. A work breakdown structure is presented with each research activity described in detail. The deliverables for each work area are summarized. The overall organization and responsibilities for each research area are described. The schedule and necessary resources are presented for each research activity. The estimated cost is summarized for each activity. The project plan is fully described in the Super Project Expert data file contained on the floppy disk attached to the back cover of this plan.

  7. Software Technology for Adaptable, Reliable Systems (STARS). Repository Integration AdaKNET Software User’s Manual

    DTIC Science & Technology

    1990-10-03

    knowledge bases via amalgama - tion of small, special-ptupose knowledge bases. For example, a fragment of the Gadfly knowledge base describing Ada...amalgamations must have as their root concept a generic con- cept which exists in the current network specification. The interpretation of amalgama - tons is

  8. Classic-Ada(TM)

    NASA Technical Reports Server (NTRS)

    Valley, Lois

    1989-01-01

    The SPS product, Classic-Ada, is a software tool that supports object-oriented Ada programming with powerful inheritance and dynamic binding. Object Oriented Design (OOD) is an easy, natural development paradigm, but it is not supported by Ada. Following the DOD Ada mandate, SPS developed Classic-Ada to provide a tool which supports OOD and implements code in Ada. It consists of a design language, a code generator and a toolset. As a design language, Classic-Ada supports the object-oriented principles of information hiding, data abstraction, dynamic binding, and inheritance. It also supports natural reuse and incremental development through inheritance, code factoring, and Ada, Classic-Ada, dynamic binding and static binding in the same program. Only nine new constructs were added to Ada to provide object-oriented design capabilities. The Classic-Ada code generator translates user application code into fully compliant, ready-to-run, standard Ada. The Classic-Ada toolset is fully supported by SPS and consists of an object generator, a builder, a dictionary manager, and a reporter. Demonstrations of Classic-Ada and the Classic-Ada Browser were given at the workshop.

  9. Proceedings of the Annual National Conference on Ada Technology (11th), Held at Williamsburg, Virginia on 15-18 March 1993

    DTIC Science & Technology

    1993-03-18

    greatly appreciated. The authors wish to thank Linda K.i Contact: The ’Archie Group’ of McGill University Braun, Debra Burns, Jo) ce Coombs, Karen Fleming...Clear Lake Bob Saisi, DSD Laboratories 5 Linda Saus, EWA Dr. Francis Van Scoy 1 I I I I I I I I I I I 11th Annual National Conference on Ada Technology...Applied Expertise, Inc. Panelists: Eric Beser, Westinghouse Linda Braun, MountainNet Pam Arya, General Research Corp. David Dlkel, Applied Expertise 1

  10. An Embedded Rule-Based Diagnostic Expert System in Ada

    NASA Technical Reports Server (NTRS)

    Jones, Robert E.; Liberman, Eugene M.

    1992-01-01

    Ada is becoming an increasingly popular programming language for large Government-funded software projects. Ada with it portability, transportability, and maintainability lends itself well to today's complex programming environment. In addition, expert systems have also assumed a growing role in providing human-like reasoning capability expertise for computer systems. The integration is discussed of expert system technology with Ada programming language, especially a rule-based expert system using an ART-Ada (Automated Reasoning Tool for Ada) system shell. NASA Lewis was chosen as a beta test site for ART-Ada. The test was conducted by implementing the existing Autonomous Power EXpert System (APEX), a Lisp-based power expert system, in ART-Ada. Three components, the rule-based expert systems, a graphics user interface, and communications software make up SMART-Ada (Systems fault Management with ART-Ada). The rules were written in the ART-Ada development environment and converted to Ada source code. The graphics interface was developed with the Transportable Application Environment (TAE) Plus, which generates Ada source code to control graphics images. SMART-Ada communicates with a remote host to obtain either simulated or real data. The Ada source code generated with ART-Ada, TAE Plus, and communications code was incorporated into an Ada expert system that reads the data from a power distribution test bed, applies the rule to determine a fault, if one exists, and graphically displays it on the screen. The main objective, to conduct a beta test on the ART-Ada rule-based expert system shell, was achieved. The system is operational. New Ada tools will assist in future successful projects. ART-Ada is one such tool and is a viable alternative to the straight Ada code when an application requires a rule-based or knowledge-based approach.

  11. Gamma ray observatory dynamics simulator in Ada (GRODY)

    NASA Technical Reports Server (NTRS)

    1990-01-01

    This experiment involved the parallel development of dynamics simulators for the Gamma Ray Observatory in both FORTRAN and Ada for the purpose of evaluating the applicability of Ada to the NASA/Goddard Space Flight Center's flight dynamics environment. The experiment successfully demonstrated that Ada is a viable, valuable technology for use in this environment. In addition to building a simulator, the Ada team evaluated training approaches, developed an Ada methodology appropriate to the flight dynamics environment, and established a baseline for evaluating future Ada projects.

  12. Gamma ray observatory dynamics simulator in Ada (GRODY)

    SciTech Connect

    Not Available

    1990-09-01

    This experiment involved the parallel development of dynamics simulators for the Gamma Ray Observatory in both FORTRAN and Ada for the purpose of evaluating the applicability of Ada to the NASA/Goddard Space Flight Center's flight dynamics environment. The experiment successfully demonstrated that Ada is a viable, valuable technology for use in this environment. In addition to building a simulator, the Ada team evaluated training approaches, developed an Ada methodology appropriate to the flight dynamics environment, and established a baseline for evaluating future Ada projects.

  13. Proceedings of the First NASA Ada Users' Symposium

    NASA Technical Reports Server (NTRS)

    1988-01-01

    Ada has the potential to be a part of the most significant change in software engineering technology within NASA in the last twenty years. Thus, it is particularly important that all NASA centers be aware of Ada experience and plans at other centers. Ada activity across NASA are covered, with presenters representing five of the nine major NASA centers and the Space Station Freedom Program Office. Projects discussed included - Space Station Freedom Program Office: the implications of Ada on training, reuse, management and the software support environment; Johnson Space Center (JSC): early experience with the use of Ada, software engineering and Ada training and the evaluation of Ada compilers; Marshall Space Flight Center (MSFC): university research with Ada and the application of Ada to Space Station Freedom, the Orbital Maneuvering Vehicle, the Aero-Assist Flight Experiment and the Secure Shuttle Data System; Lewis Research Center (LeRC): the evolution of Ada software to support the Space Station Power Management and Distribution System; Jet Propulsion Laboratory (JPL): the creation of a centralized Ada development laboratory and current applications of Ada including the Real-time Weather Processor for the FAA; and Goddard Space Flight Center (GSFC): experiences with Ada in the Flight Dynamics Division and the Extreme Ultraviolet Explorer (EUVE) project and the implications of GSFC experience for Ada use in NASA. Despite the diversity of the presentations, several common themes emerged from the program: Methodology - NASA experience in general indicates that the effective use of Ada requires modern software engineering methodologies; Training - It is the software engineering principles and methods that surround Ada, rather than Ada itself, which requires the major training effort; Reuse - Due to training and transition costs, the use of Ada may initially actually decrease productivity, as was clearly found at GSFC; and real-time work at LeRC, JPL and GSFC shows

  14. An evaluation of Ada for Al applications

    NASA Technical Reports Server (NTRS)

    Wallace, David R.

    1986-01-01

    Expert system technology seems to be the most promising type of Artificial Intelligence (AI) application for Ada. An expert system implemented with an expert system shell provides a highly structured approach that fits well with the structured approach found in Ada systems. The current commercial expert system shells use Lisp. In this highly structured situation a shell could be built that used Ada just as well. On the other hand, if it is necessary to deal with some AI problems that are not suited to expert systems, the use of Ada becomes more problematical. Ada was not designed as an AI development language, and is not suited to that. It is possible that an application developed in say, Common Lisp could be translated to Ada for actual use in a particular application, but this could be difficult. Some standard Ada packages could be developed to make such a translation easier. If the most general AI programs need to be dealt with, a Common Lisp system integrated with the Ada Environment is probably necessary. Aside from problems with language features, Ada, by itself, is not well suited to the prototyping and incremental development that is well supported by Lisp.

  15. Ada concurrent programming

    SciTech Connect

    Gehani, N.

    1984-01-01

    In this book, Narain Gehani explains the concurrent programming facilities in Ada and shows how to use them effectively in writing concurrent programs. He also surveys concurrent programming facilities in other languages, discusses issues specific to concurrent programming, and examines the limitations of the concurrent programming facilities in Ada. Topics considered include an introduction to concurrent programming, the concurrent programming model in Ada, and a survey of other concurrent programming models; tasking, i.e., concurrent programming facilities in Ada; task types; exceptions and tasking; device drivers; real-time programming; topics related to concurrent programming; more examples of concurrent programming; and synopsis of sequential programming in Ada.

  16. Ada 9X overview

    NASA Technical Reports Server (NTRS)

    Weller, David G.

    1992-01-01

    The current version of Ada has been an ANSI standard since 1983. In 1988, the Ada Joint Program Office was tasked with reevaluating the language and proposing changes to the standard. Since that time, the world has seen a tremendous explosion in object-oriented languages, as well as other growing fields such as distributed computing and support for very large software systems. The speaker will discuss new features being added to the next version of Ada, currently called Ada 9X, and what transition issues must be considered for current Ada projects.

  17. Development of an Ada programming support environment database SEAD (Software Engineering and Ada Database) administration manual

    NASA Technical Reports Server (NTRS)

    Liaw, Morris; Evesson, Donna

    1988-01-01

    Software Engineering and Ada Database (SEAD) was developed to provide an information resource to NASA and NASA contractors with respect to Ada-based resources and activities which are available or underway either in NASA or elsewhere in the worldwide Ada community. The sharing of such information will reduce duplication of effort while improving quality in the development of future software systems. SEAD data is organized into five major areas: information regarding education and training resources which are relevant to the life cycle of Ada-based software engineering projects such as those in the Space Station program; research publications relevant to NASA projects such as the Space Station Program and conferences relating to Ada technology; the latest progress reports on Ada projects completed or in progress both within NASA and throughout the free world; Ada compilers and other commercial products that support Ada software development; and reusable Ada components generated both within NASA and from elsewhere in the free world. This classified listing of reusable components shall include descriptions of tools, libraries, and other components of interest to NASA. Sources for the data include technical newletters and periodicals, conference proceedings, the Ada Information Clearinghouse, product vendors, and project sponsors and contractors.

  18. Managing Ada development

    NASA Technical Reports Server (NTRS)

    Green, James R.

    1986-01-01

    The Ada programming language was developed under the sponsorship of the Department of Defense to address the soaring costs associated with software development and maintenance. Ada is powerful, and yet to take full advantage of its power, it is sufficiently complex and different from current programming approaches that there is considerable risk associated with committing a program to be done in Ada. There are also few programs of any substantial size that have been implemented using Ada that may be studied to determine those management methods that resulted in a successful Ada project. The items presented are the author's opinions which have been formed as a result of going through an experience software development. The difficulties faced, risks assumed, management methods applied, and lessons learned, and most importantly, the techniques that were successful are all valuable sources of management information for those managers ready to assume major Ada developments projects.

  19. Righting the ADA

    ERIC Educational Resources Information Center

    National Council on Disability, 2004

    2004-01-01

    Many Americans with disabilities feel that a series of negative court decisions is reducing their status to that of "second-class citizens," a status that the Americans with Disabilities Act (ADA) was supposed to remedy forever. In this report, the National Council on Disability (NCD), which first proposed the enactment of an ADA and…

  20. 76 FR 70520 - RMD Technologies, Inc., Rockwall Holdings, Inc., Southmark Corp., Stargold Mines, Inc., Stelax...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-14

    ... Industries, Ltd., Stem Cell Innovations, Inc., and Surfect Holdings, Inc.; Order of Suspension of Trading... information concerning the securities of Stem Cell Innovations, Inc. because it has not filed any...

  1. Ada education in a software life-cycle context

    NASA Technical Reports Server (NTRS)

    Clough, Anne J.

    1986-01-01

    Some of the experience gained from a comprehensive educational program undertaken at The Charles Stark Draper Lab. to introduce the Ada language and to transition modern software engineering technology into the development of Ada and non-Ada applications is described. Initially, a core group, which included manager, engineers and programmers, received training in Ada. An Ada Office was established to assume the major responsibility for training, evaluation, acquisition and benchmarking of tools, and consultation on Ada projects. As a first step in this process, and in-house educational program was undertaken to introduce Ada to the Laboratory. Later, a software engineering course was added to the educational program as the need to address issues spanning the entire software life cycle became evident. Educational efforts to date are summarized, with an emphasis on the educational approach adopted. Finally, lessons learned in administering this program are addressed.

  2. COMPASS: An Ada based scheduler

    NASA Technical Reports Server (NTRS)

    Mcmahon, Mary Beth; Culbert, Chris

    1992-01-01

    COMPASS is a generic scheduling system developed by McDonnell Douglas and funded by the Software Technology Branch of NASA Johnson Space Center. The motivation behind COMPASS is to illustrate scheduling technology and provide a basis from which custom scheduling systems can be built. COMPASS was written in Ada to promote readability and to conform to DOD standards. COMPASS has some unique characteristics that distinguishes it from commercial products. This paper discusses these characteristics and uses them to illustrate some differences between scheduling tools.

  3. Software engineering capability for Ada (GRASP/Ada Tool)

    NASA Technical Reports Server (NTRS)

    Cross, James H., II

    1995-01-01

    The GRASP/Ada project (Graphical Representations of Algorithms, Structures, and Processes for Ada) has successfully created and prototyped a new algorithmic level graphical representation for Ada software, the Control Structure Diagram (CSD). The primary impetus for creation of the CSD was to improve the comprehension efficiency of Ada software and, as a result, improve reliability and reduce costs. The emphasis has been on the automatic generation of the CSD from Ada PDL or source code to support reverse engineering and maintenance. The CSD has the potential to replace traditional prettyprinted Ada Source code. A new Motif compliant graphical user interface has been developed for the GRASP/Ada prototype.

  4. Demonstration of Land and Hold Short Technology at the Dallas-Fort Worth International Airport

    NASA Technical Reports Server (NTRS)

    Hyer, Paul V.; Jones, Denise R. (Technical Monitor)

    2002-01-01

    A guidance system for assisting in Land and Hold Short operations was developed and then tested at the Dallas-Fort Worth International Airport. This system displays deceleration advisory information on a head-up display (HUD) in front of the airline pilot during landing. The display includes runway edges, a trend vector, deceleration advisory, locations of the hold line and of the selected exit, and alphanumeric information about the progress of the aircraft. Deceleration guidance is provided to the hold short line or to a pilot selected exit prior to this line. Logic is provided to switch the display automatically to the next available exit. The report includes descriptions of the algorithms utilized in the displays, and a report on the techniques of HUD alignment, and results.

  5. GENERAL PURPOSE ADA PACKAGES

    NASA Technical Reports Server (NTRS)

    Klumpp, A. R.

    1994-01-01

    Ten families of subprograms are bundled together for the General-Purpose Ada Packages. The families bring to Ada many features from HAL/S, PL/I, FORTRAN, and other languages. These families are: string subprograms (INDEX, TRIM, LOAD, etc.); scalar subprograms (MAX, MIN, REM, etc.); array subprograms (MAX, MIN, PROD, SUM, GET, and PUT); numerical subprograms (EXP, CUBIC, etc.); service subprograms (DATE_TIME function, etc.); Linear Algebra II; Runge-Kutta integrators; and three text I/O families of packages. In two cases, a family consists of a single non-generic package. In all other cases, a family comprises a generic package and its instances for a selected group of scalar types. All generic packages are designed to be easily instantiated for the types declared in the user facility. The linear algebra package is LINRAG2. This package includes subprograms supplementing those in NPO-17985, An Ada Linear Algebra Package Modeled After HAL/S (LINRAG). Please note that LINRAG2 cannot be compiled without LINRAG. Most packages have widespread applicability, although some are oriented for avionics applications. All are designed to facilitate writing new software in Ada. Several of the packages use conventions introduced by other programming languages. A package of string subprograms is based on HAL/S (a language designed for the avionics software in the Space Shuttle) and PL/I. Packages of scalar and array subprograms are taken from HAL/S or generalized current Ada subprograms. A package of Runge-Kutta integrators is patterned after a built-in MAC (MIT Algebraic Compiler) integrator. Those packages modeled after HAL/S make it easy to translate existing HAL/S software to Ada. The General-Purpose Ada Packages program source code is available on two 360K 5.25" MS-DOS format diskettes. The software was developed using VAX Ada v1.5 under DEC VMS v4.5. It should be portable to any validated Ada compiler and it should execute either interactively or in batch. The largest package

  6. Ada in AI or AI in Ada. On developing a rationale for integration

    NASA Technical Reports Server (NTRS)

    Collard, Philippe E.; Goforth, Andre

    1988-01-01

    The use of Ada as an Artificial Intelligence (AI) language is gaining interest in the NASA Community, i.e., by parties who have a need to deploy Knowledge Based-Systems (KBS) compatible with the use of Ada as the software standard for the Space Station. A fair number of KBS and pseudo-KBS implementations in Ada exist today. Currently, no widely used guidelines exist to compare and evaluate these with one another. The lack of guidelines illustrates a fundamental problem inherent in trying to compare and evaluate implementations of any sort in languages that are procedural or imperative in style, such as Ada, with those in languages that are functional in style, such as Lisp. Discussed are the strengths and weakness of using Ada as an AI language and a preliminary analysis provided of factors needed for the development of criteria for the integration of these two families of languages and the environments in which they are implemented. The intent for developing such criteria is to have a logical rationale that may be used to guide the development of Ada tools and methodology to support KBS requirements, and to identify those AI technology components that may most readily and effectively be deployed in Ada.

  7. Ada Namelist Package

    NASA Technical Reports Server (NTRS)

    Klumpp, Allan R.

    1991-01-01

    Ada Namelist Package, developed for Ada programming language, enables calling program to read and write FORTRAN-style namelist files. Features are: handling of any combination of types defined by user; ability to read vectors, matrices, and slices of vectors and matrices; handling of mismatches between variables in namelist file and those in programmed list of namelist variables; and ability to avoid searching entire input file for each variable. Principle benefits derived by user: ability to read and write namelist-readable files, ability to detect most file errors in initialization phase, and organization keeping number of instantiated units to few packages rather than to many subprograms.

  8. ADA Test and Evaluation

    DTIC Science & Technology

    1981-02-06

    language. LIR. 290; 13.9.1P There should be, a standard (unisafe) way of building an Ada array from a block of storaga pasmed Intoý an Ada routine...66 pqs. (TRW - USAF) 607 go pJs. (ESD/TOIT - USAF) 008 66 pgs. (AFCCPC - USAF) 669 66 pgs. (Hq.SAC - USAF) 616 66 pgs. ( Aerospace Corp. - USAF) 611...Oer.MOD/!AIO) Type CHARACTER 0611- 01 pgs. (Gor.MOD/IAUG) Record Representation* 091- 03 Pgs. Nagle(Ford Aerospace ) Integers - 92 - 66S- 61 pgs

  9. Proceedings of the National Conference on Ada (trade mark) Technology (6th) Held on 14-18 March 1988 in Arlington, VA.

    DTIC Science & Technology

    1988-03-01

    Terminology Standardization: Necessary Elements for Establishing Comparative Metrics for Software Development Methods-M. R. Arlington Ballroom-Salon V and VI...of Ada. Thus, GTE retained the lifecycle, syntax and semantics of Ada. Newer personnel have also static hierarchy, terminology , and DIDs described in...in the ARPANET. Following the terminology checks 1.48 0.45 0.75 of the IP standard [DoD83c], we refer to the data link no checks 1.25 0.32 0.52

  10. A LISP-Ada connection

    NASA Technical Reports Server (NTRS)

    Jaworski, Allan; Lavallee, David; Zoch, David

    1987-01-01

    The prototype demonstrates the feasibility of using Ada for expert systems and the implementation of an expert-friendly interface which supports knowledge entry. In the Ford LISP-Ada Connection (FLAC) system LISP and Ada are used in ways which complement their respective capabilities. Future investigation will concentrate on the enhancement of the expert knowledge entry/debugging interface and on the issues associated with multitasking and real-time expert systems implementation in Ada.

  11. Benchmark Lisp And Ada Programs

    NASA Technical Reports Server (NTRS)

    Davis, Gloria; Galant, David; Lim, Raymond; Stutz, John; Gibson, J.; Raghavan, B.; Cheesema, P.; Taylor, W.

    1992-01-01

    Suite of nonparallel benchmark programs, ELAPSE, designed for three tests: comparing efficiency of computer processing via Lisp vs. Ada; comparing efficiencies of several computers processing via Lisp; or comparing several computers processing via Ada. Tests efficiency which computer executes routines in each language. Available for computer equipped with validated Ada compiler and/or Common Lisp system.

  12. Impact of Ada in the Flight Dynamics Division: Excitement and frustration

    NASA Technical Reports Server (NTRS)

    Bailey, John; Waligora, Sharon; Stark, Mike

    1993-01-01

    In 1985, NASA Goddard's Flight Dynamics Division (FDD) began investigating how the Ada language might apply to their software development projects. Although they began cautiously using Ada on only a few pilot projects, they expected that, if the Ada pilots showed promising results, they would fully transition their entire development organization from FORTRAN to Ada within 10 years. However, nearly 9 years later, the FDD still produces 80 percent of its software in FORTRAN, despite positive results on Ada projects. This paper reports preliminary results of an ongoing study, commissioned by the FDD, to quantify the impact of Ada in the FDD, to determine why Ada has not flourished, and to recommend future directions regarding Ada. Project trends in both languages are examined as are external factors and cultural issues that affected the infusion of this technology. This paper is the first public report on the Ada assessment study, which will conclude with a comprehensive final report in mid 1994.

  13. AN ADA NAMELIST PACKAGE

    NASA Technical Reports Server (NTRS)

    Klumpp, A. R.

    1994-01-01

    The Ada Namelist Package, developed for the Ada programming language, enables a calling program to read and write FORTRAN-style namelist files. A namelist file consists of any number of assignment statements in any order. Features of the Ada Namelist Package are: the handling of any combination of user-defined types; the ability to read vectors, matrices, and slices of vectors and matrices; the handling of mismatches between variables in the namelist file and those in the programmed list of namelist variables; and the ability to avoid searching the entire input file for each variable. The principle user benefits of this software are the following: the ability to write namelist-readable files, the ability to detect most file errors in the initialization phase, a package organization that reduces the number of instantiated units to a few packages rather than to many subprograms, a reduced number of restrictions, and an increased execution speed. The Ada Namelist reads data from an input file into variables declared within a user program. It then writes data from the user program to an output file, printer, or display. The input file contains a sequence of assignment statements in arbitrary order. The output is in namelist-readable form. There is a one-to-one correspondence between namelist I/O statements executed in the user program and variables read or written. Nevertheless, in the input file, mismatches are allowed between assignment statements in the file and the namelist read procedure statements in the user program. The Ada Namelist Package itself is non-generic. However, it has a group of nested generic packages following the nongeneric opening portion. The opening portion declares a variety of useraccessible constants, variables and subprograms. The subprograms are procedures for initializing namelists for reading, reading and writing strings. The subprograms are also functions for analyzing the content of the current dataset and diagnosing errors. Two nested

  14. Software Engineering in Ada

    DTIC Science & Technology

    1988-03-22

    Avo Valmu - An aces value provides the locationi of. or "polnah. to". ani 4bjec which has been craea~d by the evaluation of an allocator. Keyword: amis...and traininp need.. of the DOD community. including methodologies and materials to rill those needu. Ada Va~lidation Orgamluatlo ( AVO ) - The component...type we the tesis for equality and inequality and the assignment operation. unless the type is limited.. in which case no operations awe implicitly

  15. Initial Ada components evaluation

    NASA Technical Reports Server (NTRS)

    Moebes, Travis

    1989-01-01

    The SAIC has the responsibility for independent test and validation of the SSE. They have been using a mathematical functions library package implemented in Ada to test the SSE IV and V process. The library package consists of elementary mathematical functions and is both machine and accuracy independent. The SSE Ada components evaluation includes code complexity metrics based on Halstead's software science metrics and McCabe's measure of cyclomatic complexity. Halstead's metrics are based on the number of operators and operands on a logical unit of code and are compiled from the number of distinct operators, distinct operands, and total number of occurrences of operators and operands. These metrics give an indication of the physical size of a program in terms of operators and operands and are used diagnostically to point to potential problems. McCabe's Cyclomatic Complexity Metrics (CCM) are compiled from flow charts transformed to equivalent directed graphs. The CCM is a measure of the total number of linearly independent paths through the code's control structure. These metrics were computed for the Ada mathematical functions library using Software Automated Verification and Validation (SAVVAS), the SSE IV and V tool. A table with selected results was shown, indicating that most of these routines are of good quality. Thresholds for the Halstead measures indicate poor quality if the length metric exceeds 260 or difficulty is greater than 190. The McCabe CCM indicated a high quality of software products.

  16. Proceedings of the Annual National Conference on Ada (Trademark) Technology (7th) Held in Washington, D.C. on March 13-16, 1989

    DTIC Science & Technology

    1989-03-16

    development of an development languages like C. in-house Ada queuing system to keep the :ompilorz busy, but not -structured design techniques overlo...Assistant to deployed to the Indian and tile Western Pacific; the Dire-ctor, Information Processing Techniques he also Assumed command of thet Surface...decision aid whtoh autoct:as the that optimix-ts the AllocatIon of specific r urte currently wenu-l technique of determining the most twOapOns) Against

  17. Proceedings of the Annual National Conference on Ada (Trade Name) Technology (4th) Held in Atlanta, Georgia on 19-20 March 1986.

    DTIC Science & Technology

    1986-01-01

    consecutive tion of Ada in an embedded real-time requests to the monitor task. In order to vector application in the case of the aircrew/ I/O controller... light detectors to score weapon hit the on-board logic processing unit. Players information. The main processor is a Motorola will report position and...ate work at the Meson Physics Facility in Los computer applications to cormunications and Alamos and as a post-graduate, he did experi- systems. He has

  18. Proceedings of the Annual National Conference on ADA Technology (9th) Held in Washington, DC on 4-7 March 1991

    DTIC Science & Technology

    1991-03-07

    NJ 07724 MS. ANTOINETTE STUART San Diego, CA 92123 Department of the Navy Technical Program Chair: MS. LAURA VEITH Washington, DC 20734 Immediate Past...R.J. and P.J.L. Wallis. 1990. PROGRAM OPERATIONAL CONCEPT DOCUMENT (OCD) SOFTWARE REUSE WITH ADA. Peter Peregrinus (DRAFT). RCI-TR-075B, Reifer...REUSE ON AFATDS CONCEPT EVALUATION by C. Alan Burnham, Robert D. Gerardi, Peter Ho, and Dr. Harry F. Joiner II Telos Corporation 55 North Gilbert Street

  19. 77 FR 50068 - Americans With Disabilities Act (ADA) Accessibility Guidelines for Transportation Vehicles

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-20

    ... TRANSPORTATION BARRIERS COMPLIANCE BOARD 36 CFR Part 1192 RIN 3014-AA38 Americans With Disabilities Act (ADA) Accessibility Guidelines for Transportation Vehicles AGENCY: Architectural and Transportation Barriers... Architectural and Transportation Barriers Compliance Board (Access Board) is holding a public...

  20. ADAS Update and Maintainability

    NASA Technical Reports Server (NTRS)

    Watson, Leela R.

    2010-01-01

    Since 2000, both the National Weather Service Melbourne (NWS MLB) and the Spaceflight Meteorology Group (SMG) have used a local data integration system (LOIS) as part of their forecast and warning operations. The original LOIS was developed by the Applied Meteorology Unit (AMU) in 1998 (Manobianco and Case 1998) and has undergone subsequent improvements. Each has benefited from three-dimensional (3-D) analyses that are delivered to forecasters every 15 minutes across the peninsula of Florida. The intent is to generate products that enhance short-range weather forecasts issued in support of NWS MLB and SMG operational requirements within East Central Florida. The current LDIS uses the Advanced Regional Prediction System (ARPS) Data Analysis System (AD AS) package as its core, which integrates a wide variety of national, regional, and local observational data sets. It assimilates all available real-time data within its domain and is run at a finer spatial and temporal resolution than current national or regional-scale analysis packages. As such, it provides local forecasters with a more comprehensive understanding of evolving fine-scale weather features. Over the years, the LDIS has become problematic to maintain since it depends on AMU-developed shell scripts that were written for an earlier version of the ADAS software. The goals of this task were to update the NWS MLB/SMG LDIS with the latest version of ADAS, incorporate new sources of observational data, and upgrade and modify the AMU-developed shell scripts written to govern the system. In addition, the previously developed ADAS graphical user interface (GUI) was updated. Operationally, these upgrades will result in more accurate depictions of the current local environment to help with short-range weather forecasting applications, while also offering an improved initialization for local versions of the Weather Research and Forecasting (WRF) model used by both groups.

  1. Fine-Tuning ADAS Algorithm Parameters for Optimizing Traffic ...

    EPA Pesticide Factsheets

    With the development of the Connected Vehicle technology that facilitates wirelessly communication among vehicles and road-side infrastructure, the Advanced Driver Assistance Systems (ADAS) can be adopted as an effective tool for accelerating traffic safety and mobility optimization at various highway facilities. To this end, the traffic management centers identify the optimal ADAS algorithm parameter set that enables the maximum improvement of the traffic safety and mobility performance, and broadcast the optimal parameter set wirelessly to individual ADAS-equipped vehicles. After adopting the optimal parameter set, the ADAS-equipped drivers become active agents in the traffic stream that work collectively and consistently to prevent traffic conflicts, lower the intensity of traffic disturbances, and suppress the development of traffic oscillations into heavy traffic jams. Successful implementation of this objective requires the analysis capability of capturing the impact of the ADAS on driving behaviors, and measuring traffic safety and mobility performance under the influence of the ADAS. To address this challenge, this research proposes a synthetic methodology that incorporates the ADAS-affected driving behavior modeling and state-of-the-art microscopic traffic flow modeling into a virtually simulated environment. Building on such an environment, the optimal ADAS algorithm parameter set is identified through an optimization programming framework to enable th

  2. Techniques and implementation of the embedded rule-based expert system using Ada

    NASA Technical Reports Server (NTRS)

    Liberman, Eugene M.; Jones, Robert E.

    1991-01-01

    Ada is becoming an increasingly popular programming language for large Government-funded software projects. Ada with its portability, transportability, and maintainability lends itself well to today's complex programming environment. In addition, expert systems have also assured a growing role in providing human-like reasoning capability and expertise for computer systems. The integration of expert system technology with Ada programming language, specifically a rule-based expert system using an ART-Ada (Automated Reasoning Tool for Ada) system shell is discussed. The NASA Lewis Research Center was chosen as a beta test site for ART-Ada. The test was conducted by implementing the existing Autonomous Power EXpert System (APEX), a Lisp-base power expert system, in ART-Ada. Three components, the rule-based expert system, a graphics user interface, and communications software make up SMART-Ada (Systems fault Management with ART-Ada). The main objective, to conduct a beta test on the ART-Ada rule-based expert system shell, was achieved. The system is operational. New Ada tools will assist in future successful projects. ART-Ada is one such tool and is a viable alternative to the straight Ada code when an application requires a rule-based or knowledge-based approach.

  3. Introduction to Image Algebra Ada

    NASA Astrophysics Data System (ADS)

    Wilson, Joseph N.

    1991-07-01

    Image Algebra Ada (IAA) is a superset of the Ada programming language designed to support use of the Air Force Armament Laboratory's image algebra in the development of computer vision application programs. The IAA language differs from other computer vision languages is several respects. It is machine independent, and an IAA translator has been implemented in the military standard Ada language. Its image operands and operations can be used to program a range of both low- and high-level vision algorithms. This paper provides an overview of the image algebra constructs supported in IAA and describes the embodiment of these constructs in the IAA extension of Ada. Examples showing the use of IAA for a range of computer vision tasks are given. The design of IAA as a superset of Ada and the implementation of the initial translator in Ada represent critical choices. The authors discuss the reasoning behind these choices as well as the benefits and drawbacks associated with them. Implementation strategies associated with the use of Ada as an implementation language for IAA are also discussed. While one can look on IAA as a program design language (PDL) for specifying Ada programs, it is useful to consider IAA as a separate language superset of Ada. This admits the possibility of directly translating IAA for implementation on special purpose architectures. This paper explores strategies for porting IAA to various architectures and notes the critical language and implementation features for porting to different architectures.

  4. Transforming AdaPT to Ada9x

    NASA Technical Reports Server (NTRS)

    Goldsack, Stephen J.; Holzbach-Valero, A. A.; Volz, Richard A.; Waldrop, Raymond S.

    1993-01-01

    How the concepts of AdaPT can be transformed into programs using the object oriented features proposed in the preliminary mapping for Ada9x are described. Emphasizing, as they do, the importance of data types as units of program, these features match well with the development of partitions as translations into Abstract Data Types which was exploited in the Ada83 translation covered in report R3. By providing a form of polymorphic type, the Ada83 version also gives support for the conformant partition idea which could be achieved in Ada83 only by using UNCHECKED CONVERSIONS. It is assumed that the reader understands AdaPT itself, but the translation into Ada83 is briefly reviewed, by applying it to a small example. This is then used to show how the same translation would be achieved in the 9x version. It is important to appreciate that the distribution features which are proposed in current mapping are not used or discussed in any detail, as those are not well matched to the AdaPT approach. Critical evaluation and comparison of these approaches is given in a separate report.

  5. Distributed and parallel Ada and the Ada 9X recommendations

    NASA Technical Reports Server (NTRS)

    Volz, Richard A.; Goldsack, Stephen J.; Theriault, R.; Waldrop, Raymond S.; Holzbacher-Valero, A. A.

    1992-01-01

    Recently, the DoD has sponsored work towards a new version of Ada, intended to support the construction of distributed systems. The revised version, often called Ada 9X, will become the new standard sometimes in the 1990s. It is intended that Ada 9X should provide language features giving limited support for distributed system construction. The requirements for such features are given. Many of the most advanced computer applications involve embedded systems that are comprised of parallel processors or networks of distributed computers. If Ada is to become the widely adopted language envisioned by many, it is essential that suitable compilers and tools be available to facilitate the creation of distributed and parallel Ada programs for these applications. The major languages issues impacting distributed and parallel programming are reviewed, and some principles upon which distributed/parallel language systems should be built are suggested. Based upon these, alternative language concepts for distributed/parallel programming are analyzed.

  6. Distributed and parallel Ada and the Ada 9X recommendations

    SciTech Connect

    Volz, R.A.; Goldsack, S.J.; Theriault, R.; Waldrop, R.S.; Holzbacher-Valero, A.A.

    1992-04-01

    Recently, the DoD has sponsored work towards a new version of Ada, intended to support the construction of distributed systems. The revised version, often called Ada9x, will become the new standard sometimes in the 1990s. It is intended that Ada9x should provide language features giving limited support for distributed system construction. The requirements for such features are given. Many of the most advanced computer applications involve embedded systems that are comprised of parallel processors or networks of distributed computers. If Ada is to become the widely adopted language envisioned by many, it is essential that suitable compilers and tools be available to facilitate the creation of distributed and parallel Ada programs for these applications. The major languages issues impacting distributed and parallel programming are reviewed, and some principles upon which distributed/parallel language systems should be built are suggested. Based upon these, alternative language concepts for distributed/parallel programming are analyzed.

  7. Holding fast.

    PubMed

    Gourville, John T

    2005-06-01

    CEO Peter Walsh faces a classic innovator's dilemma. His company, Crescordia, produces high-quality metal plates, pins, and screws that orthopedic surgeons use to repair broken bones. In fact, because the company has for decades refused to compromise on quality, there are orthopedic surgeons who use nothing but Crescordia hardware. And now these customers have begun to clamor for the next generation technology: resorbable hardware. Resorbables offer clear advantages over the traditional hardware. Like dissolving sutures, resorbable plates and screws are made of biodegradable polymers. They hold up long enough to support a healing bone, then gradually and harmlessly disintegrate in the patient's body. Surgeons are especially looking forward to using resorbables on children, so kids won't have to undergo a second operation to remove the old hardware after their bones heal, a common procedure in pediatrics. The new products, however, are not yet reliable; they fail about 8% of the time, sometimes disintegrating before the bone completely heals and sometimes not ever fully disintegrating. That's why Crescordia, mindful of its hard-earned reputation, has delayed launching a line using the new technology. But time is running out. A few competitors have begun to sell resorbables despite their imperfections, and these companies are picking up market share. Should Crescordia join the fray and risk tarnishing its brand? Or should the company sit tight until it can offer a perfect product? Commenting on this fictional case study are Robert A. Lutz, vice chairman of product development at General Motors; Clayton M. Christensen, the Robert and Jane Cizik Professor of Business Administration at Harvard Business School; Jason Wittes, a senior equity analyst covering medical supplies and devices at Leerink Swann; and Nick Galakatos, a general partner of MPM Capital.

  8. Proceedings of the Annual National Conference on Ada (Trademark) Technology (3rd) Held at Prarie View, Texas on 20-21 March 1985.

    DTIC Science & Technology

    1985-01-01

    REFERENCES algorithm analy-, artificial 1. Mickunas, M.D.. and Schell, R.M., intelligence , and com ,ing, Parallel Compilation in a Department of Computer...A ocet o OnLie sity in 1980. Dr. Wild’s research"Observer: A Concept fo On-Line interest include artificial intelligence ,Detection of Control Errors...majors can graduate without it.. . . The remaining possibilities are to substitute The nwlyichosen tie busine curi- -’-_" AdaOptfos ithe sBsi ting

  9. Update of GRASP/Ada reverse engineering tools for Ada

    NASA Technical Reports Server (NTRS)

    Cross, James H., II

    1992-01-01

    The GRASP/Ada project (Graphical Representations of Algorithms, Structures, and Processes for Ada) has successfully created and prototyped a new algorithmic level graphical representation of Ada software, the Control Structure Diagram (CSD). The primary impetus for creation of the CSD was to improve the comprehension efficiency of Ada software and, as a result, improve reliability and reduce costs. The emphasis was on the automatic generation of the CSD from Ada PDL or source code to support reverse engineering and maintenance. The CSD has the potential to replace traditional prettyprinted Ada source code. In Phase 1 of the GRASP/Ada project, the CSD graphical constructs were created and applied manually to several small Ada programs. A prototype (Version 1) was designed and implemented using FLEX and BISON running under VMS on a VAS 11-780. In Phase 2, the prototype was improved and ported to the Sun 4 platform under UNIX. A user interface was designed and partially implemented using the HP widget toolkit and the X Windows System. In Phase 3, the user interface was extensively reworked using the Athena widget toolkit and X Windows. The prototype was applied successfully to numerous Ada programs ranging in size from several hundred to several thousand lines of source code. Following Phase 3, the prototype was evaluated by software engineering students at Auburn University and then updated with significant enhancements to the user interface including editing capabilities. Version 3.2 of the prototype was prepared for limited distribution to facilitate further evaluation. The current prototype provides the capability for the user to generate CSD's from Ada PDL or source code in a reverse engineering as well as forward engineering mode with a level of flexibility suitable for practical application.

  10. ADA Guide for Small Businesses.

    ERIC Educational Resources Information Center

    Department of Justice, Washington, DC. Civil Rights Div.

    This guide presents an informal overview of some basic Americans with Disabilities Act (ADA) requirements for small businesses that provide goods or services to the public. References to key sections of the regulations or other information are included. The first section describes the ADA briefly. Section two lists the 12 categories of public…

  11. Ada Compiler Validation Summary Report: NYU Ada/ED, Version 19.7 V-001.

    DTIC Science & Technology

    1983-04-11

    SCz25 C~z37 EC85 C37304A- ABADA P SCa22 CTs63 1.7.10.9 £7.38 Validation Summary Report for NYU Ada/ED April 11, 1983 A-6 A CMplete Li3t Of Tst3 and...9 NOa 352002E- ABADA PM SWaS CT*23 ECz2 B520021-8. ADA P SCs5 CTs11 EC.1 55202- ABADA P SC85 CT89 ECul Validation Summary Report for M! Ad a/ ED April... ABADA , P SCx17 C7.16 M~al B9710OA.AB.ADA P4 SC.18 CTx18 ECal C97101AADA PH SCu13 CT.66 1..1.6£75 C9711GA-A.ADi PM SCs1 CTx17 LT.13. 76 B97115A-B.ADA

  12. Ada Structure Design Language (ASDL)

    NASA Technical Reports Server (NTRS)

    Chedrawi, Lutfi

    1986-01-01

    An artist acquires all the necessary tools before painting a scene. In the same analogy, a software engineer needs the necessary tools to provide their design with the proper means for implementation. Ada provide these tools. Yet, as an artist's painting needs a brochure to accompany it for further explanation of the scene, an Ada design also needs a document along with it to show the design in its detailed structure and hierarchical order. Ada could be self-explanatory in small programs not exceeding fifty lines of code in length. But, in a large environment, ranging from thousands of lines and above, Ada programs need to be well documented to be preserved and maintained. The language used to specify an Ada document is called Ada Structure Design Language (ASDL). This language sets some rules to help derive a well formatted Ada detailed design document. The rules are defined to meet the needs of a project manager, a maintenance team, a programmer and a systems designer. The design document templates, the document extractor, and the rules set forth by the ASDL are explained in detail.

  13. Call Numbers and Holdings of Journals Listed in Applied Science & Technology Index Located in the Libraries of North Carolina State University. Second Edition.

    ERIC Educational Resources Information Center

    Pozo, Frank, Comp.

    This document consists of the call numbers and holdings of journals listed in the "Applied Science and Technology Index" (ASTI) located in the libraries of North Carolina State University (NCSU). In addition to helping ASTI users at NCSU, it may also be used for regional and national purposes. As a regional resource it may help libraries…

  14. Update of GRASP/Ada reverse engineering tools for Ada

    NASA Technical Reports Server (NTRS)

    Cross, James H., II

    1993-01-01

    The GRASP/Ada project (Graphical Representations of Algorithms, Structures, and Processes for Ada) successfully created and prototyped a new algorithmic level graphical representation for Ada software, the Control Structure Diagram (CSD). The primary impetus for creation of the CSD was to improve the comprehension efficiency of Ada software and, as a result, improve reliability and reduce costs. The emphasis was on the automatic generation of the CSD from Ada PDL or source code to support reverse engineering and maintenance. The CSD has the potential to replace traditional pretty printed Ada source code. In Phase 1 of the GRASP/Ada project, the CSD graphical constructs were created and applied manually to several small Ada programs. A prototype CSD generator (Version 1) was designed and implemented using FLEX and BISON running under VMS on a VAX 11-780. In Phase 2, the prototype was improved and ported to the Sun 4 platform under UNIX. A user interface was designed and partially implemented using the HP widget toolkit and the X Windows System. In Phase 3, the user interface was extensively reworked using the Athena widget toolkit and X Windows. The prototype was applied successfully to numerous Ada programs ranging in size from several hundred to several thousand lines of source code. Following Phase 3,e two update phases were completed. Update'92 focused on the initial analysis of evaluation data collected from software engineering students at Auburn University and the addition of significant enhancements to the user interface. Update'93 (the current update) focused on the statistical analysis of the data collected in the previous update and preparation of Version 3.4 of the prototype for limited distribution to facilitate further evaluation. The current prototype provides the capability for the user to generate CSD's from Ada PDL or source code in a reverse engineering as well as forward engineering mode with a level of flexibility suitable for practical

  15. Real-Time Ada Demonstration Project

    DTIC Science & Technology

    1989-05-31

    CENER OR OFTAREENGINEERING ADVANCED SOFTWARE TECHNOLOGY Subject: Final Report - Real-Time Ada Demonstration Proj e-t- --.-. SEP 0 1989 D SEA)~ CIN...C02 0921I 6))00 I 31 MAY 1989 *:i ’C O~ 0"ed ~ 842 190 ?’ 45 DEMONSTRATION PROJECT FINAL REPORT PREPARED FOR: U.S. Army HQ CECOM Center for Software ...Engineering Advanced Software Technology Fort Monmouth, NJ 07703-5000 Accession For NTIS G1A&I DTIC TAB PREPARED BY: unannou:1r2d E LabTek Corporation

  16. Ada Linear-Algebra Program

    NASA Technical Reports Server (NTRS)

    Klumpp, A. R.; Lawson, C. L.

    1988-01-01

    Routines provided for common scalar, vector, matrix, and quaternion operations. Computer program extends Ada programming language to include linear-algebra capabilities similar to HAS/S programming language. Designed for such avionics applications as software for Space Station.

  17. GRASP/Ada 95: Reverse Engineering Tools for Ada

    NASA Technical Reports Server (NTRS)

    Cross, James H., II

    1996-01-01

    The GRASP/Ada project (Graphical Representations of Algorithms, Structures, and Processes for Ada) has successfully created and prototyped an algorithmic level graphical representation for Ada software, the Control Structure Diagram (CSD), and a new visualization for a fine-grained complexity metric called the Complexity Profile Graph (CPG). By synchronizing the CSD and the CPG, the CSD view of control structure, nesting, and source code is directly linked to the corresponding visualization of statement level complexity in the CPG. GRASP has been integrated with GNAT, the GNU Ada 95 Translator to provide a comprehensive graphical user interface and development environment for Ada 95. The user may view, edit, print, and compile source code as a CSD with no discernible addition to storage or computational overhead. The primary impetus for creation of the CSD was to improve the comprehension efficiency of Ada software and, as a result, improve reliability and reduce costs. The emphasis has been on the automatic generation of the CSD from Ada 95 source code to support reverse engineering and maintenance. The CSD has the potential to replace traditional prettyprinted Ada source code. The current update has focused on the design and implementation of a new Motif compliant user interface, and a new CSD generator consisting of a tagger and renderer. The Complexity Profile Graph (CPG) is based on a set of functions that describes the context, content, and the scaling for complexity on a statement by statement basis. When combined graphicafly, the result is a composite profile of complexity for the program unit. Ongoing research includes the development and refinement of the associated functions, and the development of the CPG generator prototype. The current Version 5.0 prototype provides the capability for the user to generate CSDs and CPGs from Ada 95 source code in a reverse engineering as well as forward engineering mode with a level of flexibility suitable for

  18. An Ada programming support environment

    NASA Technical Reports Server (NTRS)

    Tyrrill, AL; Chan, A. David

    1986-01-01

    The toolset of an Ada Programming Support Environment (APSE) being developed at North American Aircraft Operations (NAAO) of Rockwell International, is described. The APSE is resident on three different hosts and must support developments for the hosts and for embedded targets. Tools and developed software must be freely portable between the hosts. The toolset includes the usual editors, compilers, linkers, debuggers, configuration magnagers, and documentation tools. Generally, these are being supplied by the host computer vendors. Other tools, for example, pretty printer, cross referencer, compilation order tool, and management tools were obtained from public-domain sources, are implemented in Ada and are being ported to the hosts. Several tools being implemented in-house are of interest, these include an Ada Design Language processor based on compilable Ada. A Standalone Test Environment Generator facilitates test tool construction and partially automates unit level testing. A Code Auditor/Static Analyzer permits the Ada programs to be evaluated against measures of quality. An Ada Comment Box Generator partially automates generation of header comment boxes.

  19. Ada To X-Window Bindings

    NASA Technical Reports Server (NTRS)

    Souleles, Dean

    1993-01-01

    Ada to X-Window Bindings computer program developed to provide Ada programmers with complete interfaces to Xt Intrinsics and OSF Motif toolkits. Provides "Ada view" of some mostly C-language programming libraries. Package of software written in Ada and C languages.

  20. Paranoia.Ada: Sample output reports

    NASA Technical Reports Server (NTRS)

    1986-01-01

    Paranoia.Ada is a program to diagnose floating point arithmetic in the context of the Ada programming language. The program evaluates the quality of a floating point arithmetic implementation with respect to the proposed IEEE Standards P754 and P854. Paranoia.Ada is derived from the original BASIC programming language version of Paranoia. The Paranoia.Ada replicates in Ada the test algorithms originally implemented in BASIC and adheres to the evaluation criteria established by W. M. Kahan. Paranoia.Ada incorporates a major structural redesign and employs applicable Ada architectural and stylistic features.

  1. ART-Ada design project, phase 2

    NASA Technical Reports Server (NTRS)

    Lee, S. Daniel; Allen, Bradley P.

    1990-01-01

    Interest in deploying expert systems in Ada has increased. An Ada based expert system tool is described called ART-Ada, which was built to support research into the language and methodological issues of expert systems in Ada. ART-Ada allows applications of an existing expert system tool called ART-IM (Automated Reasoning Tool for Information Management) to be deployed in various Ada environments. ART-IM, a C-based expert system tool, is used to generate Ada source code which is compiled and linked with an Ada based inference engine to produce an Ada executable image. ART-Ada is being used to implement several expert systems for NASA's Space Station Freedom Program and the U.S. Air Force.

  2. Ada/POSIX binding: A focused Ada investigation

    NASA Technical Reports Server (NTRS)

    Legrand, Sue

    1988-01-01

    NASA is seeking an operating system interface definition (OSID) for the Space Station Program (SSP) in order to take advantage of the commercial off-the-shelf (COTS) products available today and the many that are expected in the future. NASA would also like to avoid the reliance on any one source for operating systems, information system, communication system, or instruction set architecture. The use of the Portable Operating System Interface for Computer Environments (POSIX) is examined as a possible solution to this problem. Since Ada is already the language of choice for SSP, the question of an Ada/POSIX binding is addressed. The intent of the binding is to provide access to the POSIX standard operation system (OS) interface and environment, by which application portability of Ada applications will be supported at the source code level. A guiding principle of Ada/POSIX binding development is a clear conformance of the Ada interface with the functional definition of POSIX. The interface is intended to be used by both application developers and system implementors. The objective is to provide a standard that allows a strictly conforming application source program that can be compiled to execute on any conforming implementation. Special emphasis is placed on first providing those functions and facilities that are needed in a wide variety of commercial applications

  3. Compiling knowledge-based systems from KEE to Ada

    NASA Technical Reports Server (NTRS)

    Filman, Robert E.; Bock, Conrad; Feldman, Roy

    1990-01-01

    The dominant technology for developing AI applications is to work in a multi-mechanism, integrated, knowledge-based system (KBS) development environment. Unfortunately, systems developed in such environments are inappropriate for delivering many applications - most importantly, they carry the baggage of the entire Lisp environment and are not written in conventional languages. One resolution of this problem would be to compile applications from complex environments to conventional languages. Here the first efforts to develop a system for compiling KBS developed in KEE to Ada (trademark). This system is called KATYDID, for KEE/Ada Translation Yields Development Into Delivery. KATYDID includes early prototypes of a run-time KEE core (object-structure) library module for Ada, and translation mechanisms for knowledge structures, rules, and Lisp code to Ada. Using these tools, part of a simple expert system was compiled (not quite automatically) to run in a purely Ada environment. This experience has given us various insights on Ada as an artificial intelligence programming language, potential solutions of some of the engineering difficulties encountered in early work, and inspiration on future system development.

  4. Ada Implementation Guide. Software Engineering With Ada. Volume 1

    DTIC Science & Technology

    1994-04-01

    teaching, the student is less likely to readily adopt new, more powerful ways of accomplishing old tasks 122 Depatn of the NaY I ! Trablng and Educaion and...Maturity Model3 (CMU/SEI-92-TR-25, ESC-TR-/92-0M5). Pittsburgh, PA : Carnegie-Mellon University, 1992. SBoehm. B.W. Software Engineering Economics...Pittsburgh, PA : Carnegie-Mellon University, 19-21 March 1991. £ Contrast: Ada 9X and C++, Schonberg, E. New York University, 1992 (Distributed by Ada IC on

  5. Multiprocessor performance modeling with ADAS

    NASA Technical Reports Server (NTRS)

    Hayes, Paul J.; Andrews, Asa M.

    1989-01-01

    A graph managing strategy referred to as the Algorithm to Architecture Mapping Model (ATAMM) appears useful for the time-optimized execution of application algorithm graphs in embedded multiprocessors and for the performance prediction of graph designs. This paper reports the modeling of ATAMM in the Architecture Design and Assessment System (ADAS) to make an independent verification of ATAMM's performance prediction capability and to provide a user framework for the evaluation of arbitrary algorithm graphs. Following an overview of ATAMM and its major functional rules are descriptions of the ADAS model of ATAMM, methods to enter an arbitrary graph into the model, and techniques to analyze the simulation results. The performance of a 7-node graph example is evaluated using the ADAS model and verifies the ATAMM concept by substantiating previously published performance results.

  6. Ada style guide (version 1.1)

    NASA Technical Reports Server (NTRS)

    Seidewitz, Edwin V.; Agresti, William; Ferry, Daniel; Lavallee, David; Maresca, Paul; Nelson, Robert; Quimby, Kelvin; Rosenberg, Jacob; Roy, Daniel; Shell, Allyn

    1987-01-01

    Ada is a programming language of considerable expressive power. The Ada Language Reference Manual provides a thorough definition of the language. However, it does not offer sufficient guidance on the appropriate use of Ada's powerful features. For this reason, the Goddard Space Flight Center Ada User's Group has produced this style guide which addresses such program style issues. The guide covers three areas of Ada program style: the structural decomposition of a program; the coding and the use of specific Ada features; and the textural formatting of a program.

  7. The Database Business: Managing Today--Planning for Tomorrow. Controlling Our Futures through Information Technology: What Does the Future Hold?

    ERIC Educational Resources Information Center

    Hearty, John A.; And Others

    1988-01-01

    The impact of emerging information technologies on the information industry is discussed in four papers. Topics covered include electronic delivery of full text primary literature; a brief evaluation of new information processing technologies and software; networking technologies; and the use of gateway technologies to create new products and…

  8. How I treat ADA deficiency.

    PubMed

    Gaspar, H Bobby; Aiuti, Alessandro; Porta, Fulvio; Candotti, Fabio; Hershfield, Michael S; Notarangelo, Luigi D

    2009-10-22

    Adenosine deaminase deficiency is a disorder of purine metabolism leading to severe combined immunodeficiency (ADA-SCID). Without treatment, the condition is fatal and requires early intervention. Haematopoietic stem cell transplantation is the major treatment for ADA-SCID, although survival following different donor sources varies considerably. Unlike other SCID forms, 2 other options are available for ADA-SCID: enzyme replacement therapy (ERT) with pegylated bovine ADA, and autologous haematopoietic stem cell gene therapy (GT). Due to the rarity of the condition, the lack of large scale outcome studies, and availability of different treatments, guidance on treatment strategies is limited. We have reviewed the currently available evidence and together with our experience of managing this condition propose a consensus management strategy. Matched sibling donor transplants represent a successful treatment option with high survival rates and excellent immune recovery. Mismatched parental donor transplants have a poor survival outcome and should be avoided unless other treatments are unavailable. ERT and GT both show excellent survival, and therefore the choice between ERT, MUD transplant, or GT is difficult and dependent on several factors, including accessibility to the different modalities, response of patients to long-term ERT, and the attitudes of physicians and parents to the short- and potential long-term risks associated with different treatments.

  9. Renovating To Meet ADA Standards.

    ERIC Educational Resources Information Center

    Huber, Judy; Jones, Garry

    2003-01-01

    Using the examples of Owen D. Young School in Van Hornesville, New York, and the Tonawanda City school district in Buffalo, New York, describes how school planners should take the accessibility standards mandated by the Americans with Disabilities Act (ADA) into account when renovating. (EV)

  10. Engineering the ADA from Vision to Reality with Technology (16th, Las Vegas, Nevada, June 12-17, 1993). Volume 13.

    ERIC Educational Resources Information Center

    Binion, Mary, Ed.

    This compilation of presentations from RESNA's conference proceedings focused on the progress and potential of assistive and rehabilitation technology for individuals with disabilities and ways that RESNA members could help these ideas to be realized. Papers were presented on the following topics: (1) service delivery and public policy issues; (2)…

  11. Structuring the formal definition of Ada

    NASA Technical Reports Server (NTRS)

    Hansen, Kurt W.

    1986-01-01

    The structure of the formal definition of Ada are described. At present, a difficult subset of Ada has been defined and the experience gained so far by this work is reported. Currently, the work continues towards the formal definition of the Ada language.

  12. Ada--Programming Language of the Future.

    ERIC Educational Resources Information Center

    Rudd, David

    1983-01-01

    Ada is a programing language developed for the Department of Defense, with a registered trademark. It was named for Ada Augusta, coworker of Charles Babbage and the world's first programer. The Department of Defense hopes to prevent variations and to establish Ada as a consistent, standardized language. (MNS)

  13. Software unit testing in Ada environment

    NASA Technical Reports Server (NTRS)

    Warnock, Glenn

    1986-01-01

    A validation procedure for the Ada binding of the Graphical Kernel System (GKS) is being developed. PRIOR Data Sciences is also producing a version of the GKS written in Ada. These major software engineering projects will provide an opportunity to demonstrate a sound approach for software testing in an Ada environment. The GKS/Ada validation capability will be a collection of test programs and data, and test management guidelines. These products will be used to assess the correctness, completeness, and efficiency of any GKS/Ada implementation. The GKS/Ada developers will be able to obtain the validation software for their own use. It is anticipated that this validation software will eventually be taken over by an independent standards body to provide objective assessments of GKS/Ada implementations, using an approach similar to the validation testing currently applied to Ada compilers. In the meantime, if requested, this validation software will be used to assess GKS/Ada products. The second project, implementation of GKS using the Ada language, is a conventional software engineering tasks. It represents a large body of Ada code and has some interesting testing problems associated with automatic testing of graphics routines. Here the normal test practices which include automated regression testing, independent quality assistance, test configuration management, and the application of software quality metrics will be employed. The software testing methods emphasize quality enhancement and automated procedures. Ada makes some aspects of testing easier, and introduces some concerns. These issues are addressed.

  14. NASA-evolving to Ada: Five-year plan. A plan for implementing recommendations made by the Ada and software management assessment working group

    NASA Technical Reports Server (NTRS)

    1989-01-01

    At their March 1988 meeting, members of the National Aeronautics and Space Administration (NASA) Information Resources Management (IRM) Council expressed concern that NASA may not have the infrastructure necessary to support the use of Ada for major NASA software projects. Members also observed that the agency has no coordinated strategy for applying its experiences with Ada to subsequent projects (Hinners, 27 June 1988). To deal with these problems, the IRM Council chair appointed an intercenter Ada and Software Management Assessment Working Group (ASMAWG). They prepared a report (McGarry et al., March 1989) entitled, 'Ada and Software Management in NASA: Findings and Recommendations'. That report presented a series of recommendations intended to enable NASA to develop better software at lower cost through the use of Ada and other state-of-the-art software engineering technologies. The purpose here is to describe the steps (called objectives) by which this goal may be achieved, to identify the NASA officials or organizations responsible for carrying out the steps, and to define a schedule for doing so. This document sets forth four goals: adopt agency-wide software standards and policies; use Ada as the programming language for all mission software; establish an infrastructure to support software engineering, including the use of Ada, and to leverage the agency's software experience; and build the agency's knowledge base in Ada and software engineering. A schedule for achieving the objectives and goals is given.

  15. Ada 9X Project Report: Ada 9X Requirements Document

    DTIC Science & Technology

    1990-08-27

    Reviewers which include E. Ploedereder - DR Chair ( Tartan ), G. Booch (Rational), B. Brosgol (Alsys), N. Cohen (IBM), R. Dewar (NYU), G. Dismukes...developing a report (the Ada Com- mentary Integration Document ( ACID )) that reflects the impact of the approved commentaries by suggesting revised...wording for appropriate sections of the standard. ACID would be a good starting point for satisfying this requirement. Of course, some of the approved

  16. The Impact of Ada and Object-Oriented Design in NASA Goddard's Flight Dynamics Division

    NASA Technical Reports Server (NTRS)

    Waligora, Sharon; Bailey, John; Stark, Mike

    1996-01-01

    This paper presents the highlights and key findings of 10 years of use and study of Ada and object-oriented design in NASA Goddard's Flight Dynamics Division (FDD). In 1985, the Software Engineering Laboratory (SEL) began investigating how the Ada language might apply to FDD software development projects. Although they began cautiously using Ada on only a few pilot projects, they expected that, if the Ada pilots showed promising results, the FDD would fully transition its entire development organization from FORTRAN to Ada within 10 years. However, 10 years later, the FDD still produced 80 percent of its software in FORTRAN and had begun using C and C++, despite positive results on Ada projects. This paper presents the final results of a SEL study to quantify the impact of Ada in the FDD, to determine why Ada has not flourished, and to recommend future directions regarding Ada. Project trends in both languages are examined as are external factors and cultural issues that affected the infusion of this technology. The detailed results of this study were published in a formal study report in March of 1995. This paper supersedes the preliminary results of this study that were presented at the Eighteenth Annual Software Engineering Workshop in 1993.

  17. Transmitter data collection using Ada

    NASA Technical Reports Server (NTRS)

    Conroy, B. L.

    1988-01-01

    A data collection system installed on the 400 kilowatt X-band transmitter of the Goldstone Solar System Radar is described. The data collection system is built around the off-the-shelf IEEE 488 instrumentation, linked with fiber optics, controlled by an inexpensive computer, and uses software written in the Ada language. The speed and accuracy of the system is discussed, along with programming techniques used for both data collection and reduction.

  18. Fine-Tuning ADAS Algorithm Parameters for Optimizing Traffic Safety and Mobility in Connected Vehicle Environment

    EPA Science Inventory

    With the development of the Connected Vehicle technology that facilitates wirelessly communication among vehicles and road-side infrastructure, the Advanced Driver Assistance Systems (ADAS) can be adopted as an effective tool for accelerating traffic safety and mobility optimizat...

  19. Rapid Deposition Technology Holds the Key for the World's Largest Manufacturer of Thin-Film Solar Modules (Fact Sheet)

    SciTech Connect

    Not Available

    2013-08-01

    First Solar, Inc. has been collaborating with NREL since 1991, advancing its thin-film cadmium telluride solar technology to grow from a startup company to become one of the world's largest manufacturers of solar modules, and the world's largest manufacturer of thin-film solar modules.

  20. QUEST/Ada (Query Utility Environment for Software Testing) of Ada: The development of a program analysis environment for Ada

    NASA Technical Reports Server (NTRS)

    Brown, David B.

    1988-01-01

    A history of the Query Utility Environment for Software Testing (QUEST)/Ada is presented. A fairly comprehensive literature review which is targeted toward issues of Ada testing is given. The definition of the system structure and the high level interfaces are then presented. The design of the three major components is described. The QUEST/Ada IORL System Specifications to this point in time are included in the Appendix. A paper is also included in the appendix which gives statistical evidence of the validity of the test case generation approach which is being integrated into QUEST/Ada.

  1. C Language Integrated Production System, Ada Version

    NASA Technical Reports Server (NTRS)

    Culbert, Chris; Riley, Gary; Savely, Robert T.; Melebeck, Clovis J.; White, Wesley A.; Mcgregor, Terry L.; Ferguson, Melisa; Razavipour, Reza

    1992-01-01

    CLIPS/Ada provides capabilities of CLIPS v4.3 but uses Ada as source language for CLIPS executable code. Implements forward-chaining rule-based language. Program contains inference engine and language syntax providing framework for construction of expert-system program. Also includes features for debugging application program. Based on Rete algorithm which provides efficient method for performing repeated matching of patterns. Written in Ada.

  2. Ada in Introductory Computer Science Courses

    DTIC Science & Technology

    1993-01-01

    Sacred Heart University’s current computer science curriculum has been modified in the 1992-1993 school year after receiving an ARPA grant(Advanced...grant entitled Ada in Introductory Computer Science Course, allowed for the modification of both introductory programming courses to use Ada as the...introductory computer science courses CS050 (Introduction to Computer Science ) and CS051 (Data Structures) were developed to include Ada and software

  3. ART/Ada design project, phase 1

    NASA Technical Reports Server (NTRS)

    1989-01-01

    An Ada-Based Expert System Building Tool Design Research Project was conducted. The goal was to investigate various issues in the context of the design of an Ada-based expert system building tool. An attempt was made to achieve a comprehensive understanding of the potential for embedding expert systems in Ada systems for eventual application in future projects. The current status of the project is described by introducing an operational prototype, ART/Ada. How the project was conducted is explained. The performance of the prototype is analyzed and compared with other related works. Future research directions are suggested.

  4. ATR technology holds the key to a better, faster, and safer way to perform postattack air base damage assessment

    NASA Astrophysics Data System (ADS)

    Mohd, Maqsood A.

    1993-11-01

    Modern combat aircraft depend on high quality airfield surfaces for takeoff and landings (TOLs). This makes TOL surfaces a very attractive target to enemy attack. After an attack, the number one priority of the recovery forces at a combat air base is to restore the air base's war fighting capability; therefore, an accurate and expedient assessment of damage is the first step of the restoration process. At present a damage assessment system (DAS) that can accurately, rapidly, and safely characterize and evaluate the magnitude of damage from an enemy attack with conventional weaponry such as mines and bombs does not exist. Using the systems engineering approach, this paper develops a DAS based on the promising ATR technology for improving the conduct of the postattack air base DA function. This paper also examines and identifies the sensors and the sensor fusion techniques that form the core of this DAS. Furthermore, this paper ranks the exploitable technologies and recommends test-worthy systems for further analysis.

  5. Software Engineering Laboratory Ada performance study: Results and implications

    NASA Technical Reports Server (NTRS)

    Booth, Eric W.; Stark, Michael E.

    1992-01-01

    The SEL is an organization sponsored by NASA/GSFC to investigate the effectiveness of software engineering technologies applied to the development of applications software. The SEL was created in 1977 and has three organizational members: NASA/GSFC, Systems Development Branch; The University of Maryland, Computer Sciences Department; and Computer Sciences Corporation, Systems Development Operation. The goals of the SEL are as follows: (1) to understand the software development process in the GSFC environments; (2) to measure the effect of various methodologies, tools, and models on this process; and (3) to identify and then to apply successful development practices. The activities, findings, and recommendations of the SEL are recorded in the Software Engineering Laboratory Series, a continuing series of reports that include the Ada Performance Study Report. This paper describes the background of Ada in the Flight Dynamics Division (FDD), the objectives and scope of the Ada Performance Study, the measurement approach used, the performance tests performed, the major test results, and the implications for future FDD Ada development efforts.

  6. Ada training evaluation and recommendations from the Gamma Ray Observatory Ada Development Team

    NASA Technical Reports Server (NTRS)

    1985-01-01

    The Ada training experiences of the Gamma Ray Observatory Ada development team are related, and recommendations are made concerning future Ada training for software developers. Training methods are evaluated, deficiencies in the training program are noted, and a recommended approach, including course outline, time allocation, and reference materials, is offered.

  7. Ada training evaluation and recommendations from the Gamma Ray Observatory Ada Development Team

    SciTech Connect

    Not Available

    1985-10-01

    The Ada training experiences of the Gamma Ray Observatory Ada development team are related, and recommendations are made concerning future Ada training for software developers. Training methods are evaluated, deficiencies in the training program are noted, and a recommended approach, including course outline, time allocation, and reference materials, is offered.

  8. Proceedings of the 2nd NASA Ada User's Symposium

    NASA Technical Reports Server (NTRS)

    1989-01-01

    Several presentations, mostly in viewgraph form, on various topics relating to Ada applications are given. Topics covered include the use of Ada in NASA, Ada and the Space Station, the software support environment, Ada in the Software Engineering Laboratory, Ada at the Jet Propulsion Laboratory, the Flight Telerobotic Servicer, and lessons learned in prototyping the Space Station Remote Manipulator System control.

  9. CMS-2 to Ada Translator Evaluation.

    DTIC Science & Technology

    1997-09-01

    these translators, and to provide information to CMS -2 project managers to assist them in the evaluation of costs and risks of translating CMS -2 to Ada....The objective of this evaluation was to determine the maturity of the CMS -2 to Ada translators and associated tools, to determine the capabilities of

  10. General-Purpose Ada Software Packages

    NASA Technical Reports Server (NTRS)

    Klumpp, Allan R.

    1991-01-01

    Collection of subprograms brings to Ada many features from other programming languages. All generic packages designed to be easily instantiated for types declared in user's facility. Most packages have widespread applicability, although some oriented for avionics applications. All designed to facilitate writing new software in Ada. Written on IBM/AT personal computer running under PC DOS, v.3.1.

  11. Ada (Trade Name) Bibliography. Volume 3.

    DTIC Science & Technology

    1986-02-01

    PROTOTYPING USING THE SETL PROGRAMMING LANGUAGE SCHULTZ. JAMES B., NONAFFILIATED 4642 -03 WEAPONS THAT THINK SCHULTZ, LENNART , CRONE&KOCH ORDRUPVEJ1O1,DK...AS A TARGET FOR ADA SUBRAHMANYAM, T CARTER, U. OF UTAH, SALT LAKE CITY, UTAH 84112 3455 -01 TRANSFORMATION OF ADA PROGRAMS INTO SILICON SVENSSON , GERT

  12. Paranoia.Ada: A diagnostic program to evaluate Ada floating-point arithmetic

    NASA Technical Reports Server (NTRS)

    Hjermstad, Chris

    1986-01-01

    Many essential software functions in the mission critical computer resource application domain depend on floating point arithmetic. Numerically intensive functions associated with the Space Station project, such as emphemeris generation or the implementation of Kalman filters, are likely to employ the floating point facilities of Ada. Paranoia.Ada appears to be a valuabe program to insure that Ada environments and their underlying hardware exhibit the precision and correctness required to satisfy mission computational requirements. As a diagnostic tool, Paranoia.Ada reveals many essential characteristics of an Ada floating point implementation. Equipped with such knowledge, programmers need not tremble before the complex task of floating point computation.

  13. A small evaluation suite for Ada compilers

    NASA Technical Reports Server (NTRS)

    Wilke, Randy; Roy, Daniel M.

    1986-01-01

    After completing a small Ada pilot project (OCC simulator) for the Multi Satellite Operations Control Center (MSOCC) at Goddard last year, the use of Ada to develop OCCs was recommended. To help MSOCC transition toward Ada, a suite of about 100 evaluation programs was developed which can be used to assess Ada compilers. These programs compare the overall quality of the compilation system, compare the relative efficiencies of the compilers and the environments in which they work, and compare the size and execution speed of generated machine code. Another goal of the benchmark software was to provide MSOCC system developers with rough timing estimates for the purpose of predicting performance of future systems written in Ada.

  14. The development of a program analysis environment for Ada: Reverse engineering tools for Ada

    NASA Technical Reports Server (NTRS)

    Cross, James H., II

    1991-01-01

    The Graphical Representations of Algorithms, Structures, and Processes for Ada (GRASP/Ada) has successfully created and prototyped a new algorithm level graphical representation for Ada software, the Control Structure Diagram (CSD). The primary impetus for creation of the CSD was to improve the comprehension efficiency of Ada software and thus improve reliability and reduce costs. The emphasis was on the automatic generation of the CSD from Ada source code to support reverse engineering and maintenance. The CSD has the potential to replace traditional prettyprinted Ada source code. In Phase 1 of the GRASP/Ada project, the CSD graphical constructs were created and applied manually to several small Ada programs. A prototype (Version 1) was designed and implemented using FLEX and BISON running under the Virtual Memory System (VMS) on a VAX 11-780. In Phase 2, the prototype was improved and ported to the Sun 4 platform under UNIX. A user interface was designed and partially implemented. The prototype was applied successfully to numerous Ada programs ranging in size from several hundred to several thousand lines of source code. In Phase 3 of the project, the prototype was prepared for limited distribution (GRASP/Ada Version 3.0) to facilitate evaluation. The user interface was extensively reworked. The current prototype provides the capability for the user to generate CSD from Ada source code in a reverse engineering mode with a level of flexibility suitable for practical application.

  15. Ada Compiler Validation Summary Report: New York University (NYU Ada/Ed) Compiler, Version 1.4 for VAX 11/780, Using VMS 3.5.

    DTIC Science & Technology

    1984-08-10

    AB.ADA P CT=9 EC=1 B55AOK- ABADA CT= EC= B55AO1K-AB.ADA P CT=10 EC=1 B55AO1L-AB.ADA P CT=10 EC=1 B55AO1M-AB.ADA P CT: 15 EC=1 B55AO10-AB.ADA P CT=26 EC=1... ABADA CT= EC= B71001L-AB.ADA P CT=10 EC=4 B71001M-AB.ADA P CT:10 EC=1 B71001N-AB.ADA P CT:? EC=1 B71001O-AB.ADA P CT=6 EC=1 B71001P-AB.ADA P CT=8 EC:1

  16. Development of Immunocapture-LC/MS Assay for Simultaneous ADA Isotyping and Semiquantitation.

    PubMed

    Chen, Lin-Zhi; Roos, David; Philip, Elsy

    2016-01-01

    Therapeutic proteins and peptides have potential to elicit immune responses resulting in anti-drug antibodies that can pose problems for both patient safety and product efficacy. During drug development immunogenicity is usually examined by risk-based approach along with specific strategies for developing "fit-for-purpose" bioanalytical approaches. Enzyme-linked immunosorbent assays and electrochemiluminescence immunoassays are the most widely used platform for ADA detection due to their high sensitivity and throughput. During the past decade, LC/MS has emerged as a promising technology for quantitation of biotherapeutics and protein biomarkers in biological matrices, mainly owing to its high specificity, selectivity, multiplexing, and wide dynamic range. In fully taking these advantages, we describe here an immunocapture-LC/MS methodology for simultaneous isotyping and semiquantitation of ADA in human plasma. Briefly, ADA and/or drug-ADA complex is captured by biotinylated drug or anti-drug Ab, immobilized on streptavidin magnetic beads, and separated from human plasma by a magnet. ADA is then released from the beads and subjected to trypsin digestion followed by LC/MS detection of specific universal peptides for each ADA isotype. The LC/MS data are analyzed using cut-point and calibration curve. The proof-of-concept of this methodology is demonstrated by detecting preexisting ADA in human plasma.

  17. Experiences with Ada in an embedded system

    NASA Technical Reports Server (NTRS)

    Labaugh, Robert J.

    1988-01-01

    Recent experiences with using Ada in a real time environment are described. The application was the control system for an experimental robotic arm. The objectives of the effort were to experiment with developing embedded applications in Ada, evaluating the suitability of the language for the application, and determining the performance of the system. Additional objectives were to develop a control system based on the NASA/NBS Standard Reference Model for Telerobot Control System Architecture (NASREM) in Ada, and to experiment with the control laws and how to incorporate them into the NASREM architecture.

  18. Development of an Ada package library

    NASA Technical Reports Server (NTRS)

    Burton, Bruce; Broido, Michael

    1986-01-01

    A usable prototype Ada package library was developed and is currently being evaluated for use in large software development efforts. The library system is comprised of an Ada-oriented design language used to facilitate the collection of reuse information, a relational data base to store reuse information, a set of reusable Ada components and tools, and a set of guidelines governing the system's use. The prototyping exercise is discussed and the lessons learned from it have led to the definition of a comprehensive tool set to facilitate software reuse.

  19. A low-power 20 GSps track-and-hold amplifier in 0.18 μm SiGe BiCMOS technology

    NASA Astrophysics Data System (ADS)

    Kai, Tang; Qiao, Meng; Zhigong, Wang; Yi, Zhang; Kuai, Yin; Ting, Guo

    2013-09-01

    An open-loop 20 GSps track-and-hold amplifier (THA) using fully-differential architecture to mitigate common-mode noise and suppress even-order harmonics is presented. CMOS switch and dummy switches are adopted to achieve high speed and good linearity. A cross-coupled pair is used in the input buffer to suppress the charge injection and clock feedthrough. Both the input and output buffers use an active inductor load to achieve high signal bandwidth. The THA is realized with 0.18 μm SiGe BiCMOS technology using only CMOS devices at a 1.8 V voltage supply and with a core area of 0.024 mm2. The measurement results show that the SFDR is 32.4 dB with a 4 GHz sine wave input at a 20 GSps sampling rate, and the third harmonic distortion is -48 dBc. The effective resolution bandwidth of the THA is 12 GHz and the figure of merit is only 0.028 mW/GHz.

  20. Software engineering and Ada in design

    NASA Technical Reports Server (NTRS)

    Oneill, Don

    1986-01-01

    Modern software engineering promises significant reductions in software costs and improvements in software quality. The Ada language is the focus for these software methodology and tool improvements. The IBM FSD approach, including the software engineering practices that guide the systematic design and development of software products and the management of the software process are examined. The revised Ada design language adaptation is revealed. This four level design methodology is detailed including the purpose of each level, the management strategy that integrates the software design activity with the program milestones, and the technical strategy that maps the Ada constructs to each level of design. A complete description of each design level is provided along with specific design language recording guidelines for each level. Finally, some testimony is offered on education, tools, architecture, and metrics resulting from project use of the four level Ada design language adaptation.

  1. Real-Time Ada Problem Study

    DTIC Science & Technology

    1989-03-24

    define this set of problems. The authors were chosen because of their proven expertise in real-time development with Ada. They could enrich the results of...for Real-Time Embedded Systems". LabTek Corporation, the author , had proven expertise in embedded system design utilizing Motorola MC680XO- based...processors. The second report is entitledSoftware Enineering Problems Using Ada in Computers Integral to Weapons Systems. Its author , Sonicraft, had

  2. A W-Grammar Description for ADA.

    DTIC Science & Technology

    1986-12-01

    Language Reference Manual. In MT opinion, the W- gramars fall short of this goal since they are less readable than BNF for determining Ada’s syntax, and...37 Summary . . . . . . . . . . . . . . .... . 39 V. Conclusion .. . . . . . . . . . .. . . .* . . . . 40 Ada Constructs Not Covered in W- gramar B...library unit. The problem with the Language Reference Manual description is not that BNF is too antiquated for language definition, but that English

  3. Ada developers' supplement to the recommended approach

    NASA Technical Reports Server (NTRS)

    Kester, Rush; Landis, Linda

    1993-01-01

    This document is a collection of guidelines for programmers and managers who are responsible for the development of flight dynamics applications in Ada. It is intended to be used in conjunction with the Recommended Approach to Software Development (SEL-81-305), which describes the software development life cycle, its products, reviews, methods, tools, and measures. The Ada Developers' Supplement provides additional detail on such topics as reuse, object-oriented analysis, and object-oriented design.

  4. Ada Compiler Validation Summary Report: ROLM Ada Compiler, Version 4.52 V-003.

    DTIC Science & Technology

    1983-06-03

    00 00:06 1 B97101C-AB.ADA P 11 00:00 00:04 1 89V1O1D- ABADA P 11 00:00 00:04 1 B97101E-AB.ADA P 13 00:01 00:04 4 B97102A-AB.ADA P 29 00:01 00:05 13... ABADA P 42 00:13 01:13 03:00 4 D55A03D-AB.ADA P 34 00:14 01:18 02:57 4 D55AO3E-AB.ADA P 53 00:22 01:25 02:36 3 D55AO3F-AB.ADA P 56 00:23 01:33 02:56 3...17 3 CC2002A-AB.ADA P 22 00:04 01:08 02:19 3 CC3004A-B.ADA P 28 00:07 01:16 02:20 2 CC3007A- ABADA P 53 00:11 01:32 02:22 2 CC 3011A... 5ADA P 60 00

  5. Parallel Ada benchmarks for the SVMS

    NASA Technical Reports Server (NTRS)

    Collard, Philippe E.

    1990-01-01

    The use of parallel processing paradigm to design and develop faster and more reliable computers appear to clearly mark the future of information processing. NASA started the development of such an architecture: the Spaceborne VHSIC Multi-processor System (SVMS). Ada will be one of the languages used to program the SVMS. One of the unique characteristics of Ada is that it supports parallel processing at the language level through the tasking constructs. It is important for the SVMS project team to assess how efficiently the SVMS architecture will be implemented, as well as how efficiently Ada environment will be ported to the SVMS. AUTOCLASS II, a Bayesian classifier written in Common Lisp, was selected as one of the benchmarks for SVMS configurations. The purpose of the R and D effort was to provide the SVMS project team with the version of AUTOCLASS II, written in Ada, that would make use of Ada tasking constructs as much as possible so as to constitute a suitable benchmark. Additionally, a set of programs was developed that would measure Ada tasking efficiency on parallel architectures as well as determine the critical parameters influencing tasking efficiency. All this was designed to provide the SVMS project team with a set of suitable tools in the development of the SVMS architecture.

  6. 49 CFR 37.123 - ADA paratransit eligibility: Standards.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 1 2014-10-01 2014-10-01 false ADA paratransit eligibility: Standards. 37.123... INDIVIDUALS WITH DISABILITIES (ADA) Paratransit as a Complement to Fixed Route Service § 37.123 ADA... complementary paratransit service shall provide the service to the ADA paratransit eligible...

  7. 49 CFR 37.123 - ADA paratransit eligibility: Standards.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 1 2012-10-01 2012-10-01 false ADA paratransit eligibility: Standards. 37.123... INDIVIDUALS WITH DISABILITIES (ADA) Paratransit as a Complement to Fixed Route Service § 37.123 ADA... complementary paratransit service shall provide the service to the ADA paratransit eligible...

  8. 49 CFR 37.125 - ADA paratransit eligibility: Process.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 1 2012-10-01 2012-10-01 false ADA paratransit eligibility: Process. 37.125... INDIVIDUALS WITH DISABILITIES (ADA) Paratransit as a Complement to Fixed Route Service § 37.125 ADA... § 37.121 of this part shall establish a process for determining ADA paratransit eligibility. (a)...

  9. 49 CFR 37.125 - ADA paratransit eligibility: Process.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 1 2011-10-01 2011-10-01 false ADA paratransit eligibility: Process. 37.125... INDIVIDUALS WITH DISABILITIES (ADA) Paratransit as a Complement to Fixed Route Service § 37.125 ADA... § 37.121 of this part shall establish a process for determining ADA paratransit eligibility. (a)...

  10. Toward the efficient implementation of expert systems in Ada

    NASA Technical Reports Server (NTRS)

    Lee, S. Daniel

    1990-01-01

    Here, the authors describe Ada language issues encountered during the development of ART-Ada, an expert system tool for Ada deployment. ART-Ada is being used to implement several expert system applications for the Space Station Freedom and the U.S. Air Force. Additional information is given on dynamic memory allocation.

  11. 49 CFR 37.123 - ADA paratransit eligibility: Standards.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 1 2011-10-01 2011-10-01 false ADA paratransit eligibility: Standards. 37.123... INDIVIDUALS WITH DISABILITIES (ADA) Paratransit as a Complement to Fixed Route Service § 37.123 ADA... complementary paratransit service shall provide the service to the ADA paratransit eligible...

  12. 49 CFR 37.125 - ADA paratransit eligibility: Process.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 1 2014-10-01 2014-10-01 false ADA paratransit eligibility: Process. 37.125... INDIVIDUALS WITH DISABILITIES (ADA) Paratransit as a Complement to Fixed Route Service § 37.125 ADA... § 37.121 of this part shall establish a process for determining ADA paratransit eligibility. (a)...

  13. 49 CFR 37.125 - ADA paratransit eligibility: Process.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false ADA paratransit eligibility: Process. 37.125... INDIVIDUALS WITH DISABILITIES (ADA) Paratransit as a Complement to Fixed Route Service § 37.125 ADA... § 37.121 of this part shall establish a process for determining ADA paratransit eligibility. (a)...

  14. 49 CFR 37.123 - ADA paratransit eligibility: Standards.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false ADA paratransit eligibility: Standards. 37.123... INDIVIDUALS WITH DISABILITIES (ADA) Paratransit as a Complement to Fixed Route Service § 37.123 ADA... complementary paratransit service shall provide the service to the ADA paratransit eligible...

  15. Ada Run Time Support Environments and a common APSE Interface Set. [Ada Programming Support Environment

    NASA Technical Reports Server (NTRS)

    Mckay, C. W.; Bown, R. L.

    1985-01-01

    The paper discusses the importance of linking Ada Run Time Support Environments to the Common Ada Programming Support Environment (APSE) Interface Set (CAIS). A non-stop network operating systems scenario is presented to serve as a forum for identifying the important issues. The network operating system exemplifies the issues involved in the NASA Space Station data management system.

  16. Ada Compiler Validation Summary Report: Digital Equipment Corp., VAX ada, Version 1.5, VAX 800 (Host), VAX 8800 and VAXstation II (Targets)

    DTIC Science & Technology

    1988-12-09

    under VAX/VMS, Version 4.7) and VAXstation II (under MicroVMS, Version 4.7) Completion of On-Site Testing: D T IC09 Dec 1987- E C,, SEP 0 I B J...Prepared By: D Software Standards Validation Group Institute for Computer Sciences and Technology National Bureau of Standards Building 225, Room A266...CLASSIFICATION OF THIS PAGE (When Data Enre’, d Ada Compiler Validation Summary Report: Compiler Name: VAX Ada, Version 1.5 Certificate Number: 871209SI.09014 Host

  17. An Ada inference engine for expert systems

    NASA Technical Reports Server (NTRS)

    Lavallee, David B.

    1986-01-01

    The purpose is to investigate the feasibility of using Ada for rule-based expert systems with real-time performance requirements. This includes exploring the Ada features which give improved performance to expert systems as well as optimizing the tradeoffs or workarounds that the use of Ada may require. A prototype inference engine was built using Ada, and rule firing rates in excess of 500 per second were demonstrated on a single MC68000 processor. The knowledge base uses a directed acyclic graph to represent production lines. The graph allows the use of AND, OR, and NOT logical operators. The inference engine uses a combination of both forward and backward chaining in order to reach goals as quickly as possible. Future efforts will include additional investigation of multiprocessing to improve performance and creating a user interface allowing rule input in an Ada-like syntax. Investigation of multitasking and alternate knowledge base representations will help to analyze some of the performance issues as they relate to larger problems.

  18. Atomic Data and Modelling for Fusion: the ADAS Project

    SciTech Connect

    Summers, H. P.; O'Mullane, M. G.

    2011-05-11

    The paper is an update on the Atomic Data and Analysis Structure, ADAS, since ICAM-DATA06 and a forward look to its evolution in the next five years. ADAS is an international project supporting principally magnetic confinement fusion research. It has participant laboratories throughout the world, including ITER and all its partner countries. In parallel with ADAS, the ADAS-EU Project provides enhanced support for fusion research at Associated Laboratories and Universities in Europe and ITER. OPEN-ADAS, sponsored jointly by the ADAS Project and IAEA, is the mechanism for open access to principal ADAS atomic data classes and facilitating software for their use. EXTENDED-ADAS comprises a variety of special, integrated application software, beyond the purely atomic bounds of ADAS, tuned closely to specific diagnostic analyses and plasma models.The current scientific content and scope of these various ADAS and ADAS related activities are briefly reviewed. These span a number of themes including heavy element spectroscopy and models, charge exchange spectroscopy, beam emission spectroscopy and special features which provide a broad baseline of atomic modelling and support. Emphasis will be placed on 'lifting the fundamental data baseline'--a principal ADAS task for the next few years. This will include discussion of ADAS and ADAS-EU coordinated and shared activities and some of the methods being exploited.

  19. Atomic Data and Modelling for Fusion: the ADAS Project

    NASA Astrophysics Data System (ADS)

    Summers, H. P.; O'Mullane, M. G.

    2011-05-01

    The paper is an update on the Atomic Data and Analysis Structure, ADAS, since ICAM-DATA06 and a forward look to its evolution in the next five years. ADAS is an international project supporting principally magnetic confinement fusion research. It has participant laboratories throughout the world, including ITER and all its partner countries. In parallel with ADAS, the ADAS-EU Project provides enhanced support for fusion research at Associated Laboratories and Universities in Europe and ITER. OPEN-ADAS, sponsored jointly by the ADAS Project and IAEA, is the mechanism for open access to principal ADAS atomic data classes and facilitating software for their use. EXTENDED-ADAS comprises a variety of special, integrated application software, beyond the purely atomic bounds of ADAS, tuned closely to specific diagnostic analyses and plasma models. The current scientific content and scope of these various ADAS and ADAS related activities are briefly reviewed. These span a number of themes including heavy element spectroscopy and models, charge exchange spectroscopy, beam emission spectroscopy and special features which provide a broad baseline of atomic modelling and support. Emphasis will be placed on `lifting the fundamental data baseline'—a principal ADAS task for the next few years. This will include discussion of ADAS and ADAS-EU coordinated and shared activities and some of the methods being exploited.

  20. A database management capability for Ada

    NASA Technical Reports Server (NTRS)

    Chan, Arvola; Danberg, SY; Fox, Stephen; Landers, Terry; Nori, Anil; Smith, John M.

    1986-01-01

    The data requirements of mission critical defense systems have been increasing dramatically. Command and control, intelligence, logistics, and even weapons systems are being required to integrate, process, and share ever increasing volumes of information. To meet this need, systems are now being specified that incorporate data base management subsystems for handling storage and retrieval of information. It is expected that a large number of the next generation of mission critical systems will contain embedded data base management systems. Since the use of Ada has been mandated for most of these systems, it is important to address the issues of providing data base management capabilities that can be closely coupled with Ada. A comprehensive distributed data base management project has been investigated. The key deliverables of this project are three closely related prototype systems implemented in Ada. These three systems are discussed.

  1. Ada software productivity prototypes: A case study

    NASA Technical Reports Server (NTRS)

    Hihn, Jairus M.; Habib-Agahi, Hamid; Malhotra, Shan

    1988-01-01

    A case study of the impact of Ada on a Command and Control project completed at the Jet Propulsion Laboratory (JPL) is given. The data for this study was collected as part of a general survey of software costs and productivity at JPL and other NASA sites. The task analyzed is a successful example of the use of rapid prototyping as applied to command and control for the U.S. Air Force and provides the U.S. Air Force Military Airlift Command with the ability to track aircraft, air crews and payloads worldwide. The task consists of a replicated database at several globally distributed sites. The local databases at each site can be updated within seconds after changes are entered at any one site. The system must be able to handle up to 400,000 activities per day. There are currently seven sites, each with a local area network of computers and a variety of user displays; the local area networks are tied together into a single wide area network. Using data obtained for eight modules, totaling approximately 500,000 source lines of code, researchers analyze the differences in productivities between subtasks. Factors considered are percentage of Ada used in coding, years of programmer experience, and the use of Ada tools and modern programming practices. The principle findings are the following. Productivity is very sensitive to programmer experience. The use of Ada software tools and the use of modern programming practices are important; without such use Ada is just a large complex language which can cause productivity to decrease. The impact of Ada on development effort phases is consistent with earlier reports at the project level but not at the module level.

  2. Ada (Trade Name) Bibliography. Volume 2.

    DTIC Science & Technology

    1984-03-01

    for every journal. The publisher information V,.0 appears if the document is a textbook. N % Xle r , , % 1= &-6 Ada Bibliography Volume 11 9 3. DOCUMENT...THE ADA LkNGUAGE SYSTEM PROJECT RAKITIN. STEVEN R . 6TH INT’L CONF ON SOFTWARE ENGINEERING: POSTER SESSION, PP. 49-50. 09/16/82 This paper discusses...VALIDATION AVAILABLE FROM: NATL.TECHNCL INF.SVC.5285 PORT ROYAL RD,SPRINGFIELD.VA SPONSORS: U.S.ARMY,COMMUNICATIONS R & D COMND, FT.MONMOUTH, NJ DOCUMENT

  3. Knowledge representation into Ada parallel processing

    NASA Technical Reports Server (NTRS)

    Masotto, Tom; Babikyan, Carol; Harper, Richard

    1990-01-01

    The Knowledge Representation into Ada Parallel Processing project is a joint NASA and Air Force funded project to demonstrate the execution of intelligent systems in Ada on the Charles Stark Draper Laboratory fault-tolerant parallel processor (FTPP). Two applications were demonstrated - a portion of the adaptive tactical navigator and a real time controller. Both systems are implemented as Activation Framework Objects on the Activation Framework intelligent scheduling mechanism developed by Worcester Polytechnic Institute. The implementations, results of performance analyses showing speedup due to parallelism and initial efficiency improvements are detailed and further areas for performance improvements are suggested.

  4. Formal specification and verification of Ada software

    NASA Technical Reports Server (NTRS)

    Hird, Geoffrey R.

    1991-01-01

    The use of formal methods in software development achieves levels of quality assurance unobtainable by other means. The Larch approach to specification is described, and the specification of avionics software designed to implement the logic of a flight control system is given as an example. Penelope is described which is an Ada-verification environment. The Penelope user inputs mathematical definitions, Larch-style specifications and Ada code and performs machine-assisted proofs that the code obeys its specifications. As an example, the verification of a binary search function is considered. Emphasis is given to techniques assisting the reuse of a verification effort on modified code.

  5. Ada (Trade Name) Bibliography. Volume 1.

    DTIC Science & Technology

    1983-05-01

    if dtmfn fro Roe( MENTARY NOTESBM F1J LL COp~y IS. KEY WORDS fCoolnan vo usoo aid* it necesary and idenify by bloctmonbo architecture, programming...AINST LANAN RD NAY 83 ND9S-8-C-936 UNCLASSIFIED F/6 12/5 ML -4.4 ’-4-4----" ’°p..l i . d N N L. 131 t ’ ll /II~ Ada Bibliography Volume I 95 𔃾- This...Structure Editor(GLSE) and the meta-tool called PEGASYS . GLSE operates • on a class of languages that can be described with an abstract syntax (Ada and

  6. ADA Integrated Environment I. System Specification.

    DTIC Science & Technology

    1981-12-01

    returned. UNCLASSIFIED SECt AITY CLASSIFICATION O r THiS PAGE ("On’ Dese ,9nA.,d)l ,_ REPORT DOCUMENTATION PAGE BEFO scOL’No RM 1. RqEPl~ORT, NUM1191N 2...statements, symbols, names, etc.; 2. build and develop (and maintain) Ada programs by linking (and maintaining) collections of separate Ada...program build by selecting a consistent set of library units for input to the Linker. Only those units actually used shall be included; 22 INTERMETRICS

  7. Two Drosophila Ada2 Homologues Function in Different Multiprotein Complexes

    PubMed Central

    Kusch, Thomas; Guelman, Sebastián; Abmayr, Susan M.; Workman, Jerry L.

    2003-01-01

    The reversible acetylation of the N-terminal tails of histones is crucial for transcription, DNA repair, and replication. The enzymatic reaction is catalyzed by large multiprotein complexes, of which the best characterized are the Gcn5-containing N-acetyltransferase (GNAT) complexes. GNAT complexes from yeast to humans share several conserved subunits, such as Ada2, Ada3, Spt3, and Tra1/TRRAP. We have characterized these factors in Drosophila and found that the flies have two distinct Ada2 variants (dAda2a and dAda2b). Using a combination of biochemical and cell biological approaches we demonstrate that only one of the two Drosophila Ada2 homologues, dAda2b, is a component of Spt-Ada-Gcn5-acetyltransferase (SAGA) complexes. The other Ada2 variant, dAda2a, can associate with dGcn5 but is not incorporated into dSAGA-type complexes. This is the first example of a complex-specific association of the Ada-type transcriptional adapter proteins with GNATs. In addition, dAda2a is part of Gcn5-independent complexes, which are concentrated at transcriptionally active regions on polytene chromosomes. This implicates novel functions for dAda2a in transcription. Humans and mice also possess two Ada2 variants with high homology to dAda2a and dAda2b, respectively. This suggests that the mammalian and fly homologues of the transcriptional adapter Ada2 form two functionally distinct subgroups with unique characteristics. PMID:12697829

  8. When the Americans with Disabilities Act Goes Online: Application of the ADA to the Internet and the Worldwide Web. Position Paper.

    ERIC Educational Resources Information Center

    National Council on Disability, Washington, DC.

    This paper addresses the issue of how the Americans with Disabilities Act (ADA) applies to commercial and other private sector Web sites. Beginning with a brief discussion of the role electronic communication plays in our lives, the paper then considers the placement of the ADA in the context of current technology and of computer usage in the…

  9. Alma Flor Ada: Writer, Translator, Storyteller.

    ERIC Educational Resources Information Center

    Brodie, Carolyn S.

    2003-01-01

    Discusses the work of children's author Alma Flor Ada, a Cuban native who has won awards honoring Latino writers and illustrators. Includes part of an interview that explores her background, describes activity ideas, and presents a bibliography of works written by her (several title published in both English and Spanish) as well as sources of…

  10. The ADA Mandate for Social Change.

    ERIC Educational Resources Information Center

    Wehman, Paul, Ed.

    This book analyzes the effectiveness and implications for social change of the Americans with Disabilities Act (ADA). It outlines several issues--legal implications, physical accessibility, transportation options, employment opportunities, and recreation--that stimulate community action for full inclusion. Part I, titled "Definitions and…

  11. Using ADA Tasks to Simulate Operating Equipment

    NASA Technical Reports Server (NTRS)

    DeAcetis, Louis A.; Schmidt, Oron; Krishen, Kumar

    1990-01-01

    A method of simulating equipment using ADA tasks is discussed. Individual units of equipment are coded as concurrently running tasks that monitor and respond to input signals. This technique has been used in a simulation of the space-to-ground Communications and Tracking subsystem of Space Station Freedom.

  12. Using Ada tasks to simulate operating equipment

    NASA Technical Reports Server (NTRS)

    Deacetis, Louis A.; Schmidt, Oron; Krishen, Kumar

    1990-01-01

    A method of simulating equipment using Ada tasks is discussed. Individual units of equipment are coded as concurrently running tasks that monitor and respond to input signals. This technique has been used in a simulation of the space-to-ground Communications and Tracking subsystem of Space Station Freedom.

  13. Is Your Queuing System ADA-Compliant?

    ERIC Educational Resources Information Center

    Lawrence, David

    2002-01-01

    Discusses the Americans with Disabilities (ADA) and Uniform Federal Accessibility Standards (UFAS) regulations regarding public facilities' crowd control stanchions and queuing systems. The major elements are protruding objects and wheelchair accessibility. Describes how to maintain compliance with the regulations and offers a list of additional…

  14. AdaNET prototype library administration manual

    NASA Technical Reports Server (NTRS)

    Hanley, Lionel

    1989-01-01

    The functions of the AdaNET Prototype Library of Reusable Software Parts is described. Adopted from the Navy Research Laboratory's Reusability Guidebook (V.5.0), this is a working document, customized for use the the AdaNET Project. Within this document, the term part is used to denote the smallest unit controlled by a library and retrievable from it. A part may have several constituents, which may not be individually tracked. Presented are the types of parts which may be stored in the library and the relationships among those parts; a concept of trust indicators which provide measures of confidence that a user of a previously developed part may reasonably apply to a part for a new application; search and retrieval, configuration management, and communications among those who interact with the AdaNET Prototype Library; and the AdaNET Prototype, described from the perspective of its three major users: the part reuser and retriever, the part submitter, and the librarian and/or administrator.

  15. Evaluation of ADA gene expression and transduction efficiency in ADA/SCID patients undergoing gene therapy.

    PubMed

    Carlucci, F; Tabucchi, A; Aiuti, A; Rosi, F; Floccari, F; Pagani, R; Marinello, E

    2004-10-01

    A capillary electrophoresis (CE) method was developed for ADA/SCID diagnosis and monitoring of enzyme replacement therapy, as well as for exploring the transfection efficiency for different retroviral vectors in gene therapy.

  16. Ada (Trade Name) Compiler Validation Summary Report: Intermetrics, Inc. I2Ada Compiler, Version 17.08 for the IBM 370 Architecture under UTS 2.3.

    DTIC Science & Technology

    1985-12-10

    SPEC-AE.ADA P REPORTBODY-B.ADA P *CHECK FILE-B.ADA P CZ110A- ABADA *CZ11O1A-AB.ADA P CZ11O2A-B.ADA P *CZ121A-B.ADA P CZ12O1A-AB.ADA P CZ12O1B-AB.ADA P...B55AO1E-AB.ADA P B59001H- ABADA P B52003B-AB.ADA P B55AO1F-AB.ADA P B590011-AB.ADA P B52003C-AB.ADA P B55AO1G-AB.ADA P C51002A-AB.ADA P *B52OO04A...AB.ADA P P C95012A-B.ADA P C96005B-B.TST P C97203E-AB.ADA P *C95013A-B.ADA P C96005C-B.TST P C97204A-B.ADA P C95021A-B.ADA P C96005D-B.ADA P C97303A- ABADA

  17. Preliminary Version: Ada (Trade Name)/SQL: A Standard, Portable Ada-DBMS Interface.

    DTIC Science & Technology

    1987-04-01

    process the SQL functions of ’ SELECT, UPDATE, INSERT, and DELETE. 2.4. Application and Tool Portability Concerns Ada/SQL is more than just an interface...database to the underlying DBMS. Once the database has been defined, the application programs may use Ada/SQL statements to process the data stored...totally transportable. Output can also be targeted for bulk load of a database, if warranted by the data volumes and processing speed. As already noted

  18. The computerization of programming: Ada (R) lessons learned

    NASA Technical Reports Server (NTRS)

    Struble, Dennis D.

    1986-01-01

    One of the largest systems yet written in Ada has been constructed. This system is the Intermetrics Ada compiler. Many lessons have been learned during the implementation of this Ada compiler. Some of these lessons, concentrating on those lessons relevant to large system implementations are described. The characteristics of the Ada compiler implementation project at Intermetrics are also described. Some specific experiences during the implementation are pointed out.

  19. Immunologic reconstitution during PEG-ADA therapy in an unusual mosaic ADA deficient patient.

    PubMed

    Liu, Ping; Santisteban, Ines; Burroughs, Lauri M; Ochs, Hans D; Torgerson, Troy R; Hershfield, Michael S; Rawlings, David J; Scharenberg, Andrew M

    2009-02-01

    We report detailed genetic and immunologic studies in a patient diagnosed with adenosine deaminase (ADA) deficiency and combined immune deficiency at age 5 years. At the time of diagnosis, although all other lymphocyte subsets were depleted, circulating CD8(+) T cells with a terminally differentiated phenotype were abundant and expressed normal ADA activity due to a reversion mutation in a CD8(+) T cell or precursor. Over the first 9 months of replacement therapy with PEG-ADA, the patient steadily accumulated mature naïve CD4(+) and CD8(+) T cells, as well as CD4(+)/FOXP3(+) regulatory T cells, consistent with restoration of a functional cellular immune system. While CD19(+) naïve B cells also accumulated in response to PEG-ADA therapy, a high proportion of these B cells exhibited an immature surface marker phenotype even after 9 months, and immunization with neoantigen bacteriophage varphiX174 demonstrated a markedly subnormal humoral immune response. Our observations in this single patient have important implications for gene therapy of human ADA deficiency, as they indicate that ADA expression within even a large circulating lymphocyte population may not be sufficient to support adequate immune reconstitution. They also suggest that an immature surface marker phenotype of the peripheral B cell compartment may be a useful surrogate marker for incomplete humoral immune reconstitution during enzyme replacement, and possibly other forms of hematopoietic cell therapies.

  20. Knowledge, programming, and programming cultures: LISP, C, and Ada

    NASA Technical Reports Server (NTRS)

    Rochowiak, Daniel

    1990-01-01

    The results of research 'Ada as an implementation language for knowledge based systems' are presented. The purpose of the research was to compare Ada to other programming languages. The report focuses on the programming languages Ada, C, and Lisp, the programming cultures that surround them, and the programming paradigms they support.

  1. Experience with Ada on the F-18 High Alpha Research Vehicle flight test program

    NASA Technical Reports Server (NTRS)

    Regenie, Victoria A.; Earls, Michael; Le, Jeanette; Thomson, Michael

    1994-01-01

    Considerable experience has been acquired with Ada at the NASA Dryden Flight Research Facility during the on-going High Alpha Technology Program. In this program, an F-18 aircraft has been highly modified by the addition of thrust-vectoring vanes to the airframe. In addition, substantial alteration was made in the original quadruplex flight control system. The result is the High Alpha Research Vehicle. An additional research flight control computer was incorporated in each of the four channels. Software for the research flight control computer was written Ada. To date, six releases of this software have been flown. This paper provides a detailed description of the modifications to the research flight control system. Efficient ground-testing of the software was accomplished by using simulations that used the Ada for portions of their software. These simulations are also described. Modifying and transferring the Ada flight software to the software simulation configuration has allowed evaluation of this language. This paper also discusses such significant issues in using Ada as portability, modifiability, and testability as well as documentation requirements.

  2. Experience with Ada on the F-18 High Alpha Research Vehicle Flight Test Program

    NASA Technical Reports Server (NTRS)

    Regenie, Victoria A.; Earls, Michael; Le, Jeanette; Thomson, Michael

    1992-01-01

    Considerable experience was acquired with Ada at the NASA Dryden Flight Research Facility during the on-going High Alpha Technology Program. In this program, an F-18 aircraft was highly modified by the addition of thrust-vectoring vanes to the airframe. In addition, substantial alteration was made in the original quadruplex flight control system. The result is the High Alpha Research Vehicle. An additional research flight control computer was incorporated in each of the four channels. Software for the research flight control computer was written in Ada. To date, six releases of this software have been flown. This paper provides a detailed description of the modifications to the research flight control system. Efficient ground-testing of the software was accomplished by using simulations that used the Ada for portions of their software. These simulations are also described. Modifying and transferring the Ada for flight software to the software simulation configuration has allowed evaluation of this language. This paper also discusses such significant issues in using Ada as portability, modifiability, and testability as well as documentation requirements.

  3. Removable hand hold

    NASA Technical Reports Server (NTRS)

    Corrigan, Robert D. (Inventor); Hauer, Robert L. (Inventor)

    1992-01-01

    A hand hold utilizes joining mechanisms which comprises two different mounting brackets that are permanently fastened to a supporting structure. A slide plate is disposed at one end of the hand rail or hand hold which mates with one of the mounting brackets. A securing member is disposed at the opposite end of the hand rail/hand hold which connects with the other mounting bracket by means of a locking device. The slide plate has a central tapered tongue with two matching slots disposed on each side thereof.

  4. Ada (Trade Name) Compiler Validation Summary Report: Harris Corporation. Harris Ada Compiler, Version 3.1. Harris H1200.

    DTIC Science & Technology

    1987-06-03

    DATE Ada Joint Pi’ogram Office 33 June 1987 United States Department of Defense 13. NUMBER Of PAGLS Washington, DC 20301-3081 37 14. MONITORING...Prepared By: Ada Validation Facility ASD/SCOL l Wright-Patterson AFB OH 454133-6503 Prepared For: Ada Joint Program Office United States Department of...Defense Washington, D.C. MAda. is a registered trademark of the United States Government (Ada Joint Program Office). + + + Place NTIS form here

  5. Ada and software management in NASA: Assessment and recommendations

    NASA Technical Reports Server (NTRS)

    1989-01-01

    Recent NASA missions have required software systems that are larger, more complex, and more critical than NASA software systems of the past. The Ada programming language and the software methods and support environments associated with it are seen as potential breakthroughs in meeting NASA's software requirements. The findings of a study by the Ada and Software Management Assessment Working Group (ASMAWG) are presented. The study was chartered to perform three tasks: (1) assess the agency's ongoing and planned Ada activities; (2) assess the infrastructure (standards, policies, and internal organizations) supporting software management and the Ada activities; and (3) present an Ada implementation and use strategy appropriate for NASA over the next 5 years.

  6. Ada (Trade Name)/SQL (Structured Query Language) Binding Specification

    DTIC Science & Technology

    1988-06-01

    which it is contained. 6) A libary package is an <authorization package>; a <schema package>; a <global variable pack- age>; the Ada/SQL definition...Ada/SQL DML unit>s, however, may reference arbitrary Ada library units. SRld is designed to enable Ada/SQL automated tools to readily determine...restriction is designed to minimize confusion about what is being refer- enced, as well as to simplify the development of Ada/SQL automated took. 3) A non

  7. Breath-Holding Spells

    MedlinePlus

    ... Lessons? Visit KidsHealth in the Classroom What Other Parents Are Reading Your Child's Development (Birth to 3 Years) Feeding Your 1- to 3-Month-Old Feeding Your 4- to 7-Month-Old Feeding Your 8- to 12-Month-Old Feeding Your 1- to 2-Year-Old Breath-Holding ... > For Parents > Breath-Holding Spells Print A A A What's ...

  8. Ada Compiler Validation Summary Report, Dansk Datamatik Center, VAX 11 Compiler Version 1.1.

    DTIC Science & Technology

    1984-11-06

    B37303A.ADA P B3T307B-AB.ADA P B37309B-AB.ADA P B373103-B.ADA P B37311A-AB.ADA P B38001A.ADA P B38003A-AB.ADA P B38008A-B.ADA P B38008B- ABADA P B38101A-B.ADA...B452O8C-BADA P 8J45208G-AB.ADA P B45208H-B. ADA P B45208I-B.ADA P B45208M-AB.ADA P B45208N-AB.ADA P B45208S- ABADA P D45208T-AB.ADA P B45261A-kB.ADA P...B55AOIC-AB-ADA P B55AO1D-AB.ADA P B55AOlE-A3.ADA P B55A01F-AB.ADA P B55A0O-AB.ADA P B55A0IH-AB.ADA P B55A01I-AB-ADA P B55A014-AB.ADA P B55A01K- ABADA P

  9. Ada for Embedded Systems: Issues and Questions.

    DTIC Science & Technology

    1987-12-01

    appropriate order based on the task dependency hierarchy, which the ART maintains and adds to when tasks are created [ Reino 86]. The master-slave, parent...termination are needed [ Reino 86]. Tasks provide a considerable overhead in the runtime system because the status must be maintained for context...Practitioners Approach. McGraw-Hill International, 1982. [ Reino 86] Kurki-Suonio, R. An Operational Model for Ada Tasking. Technical Report 1/1986, Tampere

  10. The Katydid system for compiling KEE applications to Ada

    NASA Technical Reports Server (NTRS)

    Filman, Robert E.; Bock, Conrad; Feldman, Roy

    1990-01-01

    Components of a system known as Katydid are developed in an effort to compile knowledge-based systems developed in a multimechanism integrated environment (KEE) to Ada. The Katydid core is an Ada library supporting KEE object functionality, and the other elements include a rule compiler, a LISP-to-Ada translator, and a knowledge-base dumper. Katydid employs translation mechanisms that convert LISP knowledge structures and rules to Ada and utilizes basic prototypes of a run-time KEE object-structure library module for Ada. Preliminary results include the semiautomatic compilation of portions of a simple expert system to run in an Ada environment with the described algorithms. It is suggested that Ada can be employed for AI programming and implementation, and the Katydid system is being developed to include concurrency and synchronization mechanisms.

  11. Ada (trademark) projects at NASA. Runtime environment issues and recommendations

    NASA Technical Reports Server (NTRS)

    Roy, Daniel M.; Wilke, Randall W.

    1988-01-01

    Ada practitioners should use this document to discuss and establish common short term requirements for Ada runtime environments. The major current Ada runtime environment issues are identified through the analysis of some of the Ada efforts at NASA and other research centers. The runtime environment characteristics of major compilers are compared while alternate runtime implementations are reviewed. Modifications and extensions to the Ada Language Reference Manual to address some of these runtime issues are proposed. Three classes of projects focusing on the most critical runtime features of Ada are recommended, including a range of immediately feasible full scale Ada development projects. Also, a list of runtime features and procurement issues is proposed for consideration by the vendors, contractors and the government.

  12. SEL Ada reuse analysis and representations

    NASA Technical Reports Server (NTRS)

    Kester, Rush

    1990-01-01

    Overall, it was revealed that the pattern of Ada reuse has evolved from initial reuse of utility components into reuse of generalized application architectures. Utility components were both domain-independent utilities, such as queues and stacks, and domain-specific utilities, such as those that implement spacecraft orbit and attitude mathematical functions and physics or astronomical models. The level of reuse was significantly increased with the development of a generalized telemetry simulator architecture. The use of Ada generics significantly increased the level of verbatum reuse, which is due to the ability, using Ada generics, to parameterize the aspects of design that are configurable during reuse. A key factor in implementing generalized architectures was the ability to use generic subprogram parameters to tailor parts of the algorithm embedded within the architecture. The use of object oriented design (in which objects model real world entities) significantly improved the modularity for reuse. Encapsulating into packages the data and operations associated with common real world entities creates natural building blocks for reuse.

  13. ADA interpretative system for image algebra

    NASA Astrophysics Data System (ADS)

    Murillo, Juan J.; Wilson, Joseph N.

    1992-06-01

    An important research problem in image processing is to find appropriate tools to support algorithm development. There have been efforts to build algorithm development support systems for image algebra in several languages, but these systems still have the disadvantage of the time consuming algorithm development style associated with compilation-oriented programming. This paper starts with a description of the Run-Time Support Library (RTSL), which serves as the base for executing programs on both the Image Algebra Ada Translator (IAAT) and Image Algebra Ada Interpreter (IAAI). A presentation on the current status of IAAT and its capabilities is followed by a brief introduction to the utilization of the Image Display Manager (IDM) for image manipulation and analysis. We then discuss in detail the current development stage of IAAI and its relation with RTSL and IDM. The last section describes the design of a syntax-directed graphical user interface for IAAI. We close with an analysis of the current performance of IAAI, and future trends are discussed. Appendix A gives a brief introduction to Image Algebra (IA), and in Appendix B the reader is presented to the Image Algebra Ada (IAA) grammar.

  14. SDI satellite autonomy using AI and Ada

    NASA Technical Reports Server (NTRS)

    Fiala, Harvey E.

    1990-01-01

    The use of Artificial Intelligence (AI) and the programming language Ada to help a satellite recover from selected failures that could lead to mission failure are described. An unmanned satellite will have a separate AI subsystem running in parallel with the normal satellite subsystems. A satellite monitoring subsystem (SMS), under the control of a blackboard system, will continuously monitor selected satellite subsystems to become alert to any actual or potential problems. In the case of loss of communications with the earth or the home base, the satellite will go into a survival mode to reestablish communications with the earth. The use of an AI subsystem in this manner would have avoided the tragic loss of the two recent Soviet probes that were sent to investigate the planet Mars and its moons. The blackboard system works in conjunction with an SMS and a reconfiguration control subsystem (RCS). It can be shown to be an effective way for one central control subsystem to monitor and coordinate the activities and loads of many interacting subsystems that may or may not contain redundant and/or fault-tolerant elements. The blackboard system will be coded in Ada using tools such as the ABLE development system and the Ada Production system.

  15. Object-oriented programming with mixins in Ada

    NASA Technical Reports Server (NTRS)

    Seidewitz, ED

    1992-01-01

    Recently, I wrote a paper discussing the lack of 'true' object-oriented programming language features in Ada 83, why one might desire them in Ada, and how they might be added in Ada 9X. The approach I took in this paper was to build the new object-oriented features of Ada 9X as much as possible on the basic constructs and philosophy of Ada 83. The object-oriented features proposed for Ada 9X, while different in detail, are based on the same kind of approach. Further consideration of this approach led me on a long reflection on the nature of object-oriented programming and its application to Ada. The results of this reflection, presented in this paper, show how a fairly natural object-oriented style can indeed be developed even in Ada 83. The exercise of developing this style is useful for at least three reasons: (1) it provides a useful style for programming object-oriented applications in Ada 83 until new features become available with Ada 9X; (2) it demystifies many of the mechanisms that seem to be 'magic' in most object-oriented programming languages by making them explicit; and (3) it points out areas that are and are not in need of change in Ada 83 to make object-oriented programming more natural in Ada 9X. In the next four sections I will address in turn the issues of object-oriented classes, mixins, self-reference and supertyping. The presentation is through a sequence of examples. This results in some overlap with that paper, but all the examples in the present paper are written entirely in Ada 83. I will return to considerations for Ada 9X in the last section of the paper.

  16. Procedures and tools for building large Ada systems

    NASA Technical Reports Server (NTRS)

    Hyde, Ben

    1986-01-01

    Some of the problems unique to building a very large Ada system are addressed. This is done through examples from experience. In the winter of 1985 and 1986, Intermetrics bootstrapped the Ada compiler, which was being built over the last few years. This system consists of about one million lines of full Ada. Over the last few years a number of procedures and tools were adopted for managing the life cycle of each of the many parts of an Ada system. Many of these procedures are well known to most system builders: release management, quality assurance testing; and source file revision control. Others are unique to working in an Ada language environment; i.e., recompilation management, Ada program library management, and managing multiple implementations. First a look is taken at how a large Ada system is broken down into pieces. The Ada definition leaves unspecified a number of issues that the system builder must address: versions, subsystems, multiple implementations, and synchronization of branched development paths. Having introduced how the Ada systems are decomposed, a look is taken, via a series of examples, at how the life cylces of those parts is managed. The procedures and tools used to manage the evolution of the system are examined. It is hoped that other Ada system builders can build upon the experience of the last few years.

  17. QUEST/Ada: Query utility environment for software testing of Ada

    NASA Technical Reports Server (NTRS)

    Brown, David B.

    1989-01-01

    Results of research and development efforts are presented for Task 1, Phase 2 of a general project entitled, The Development of a Program Analysis Environment for Ada. A prototype of the QUEST/Ada system was developed to collect data to determine the effectiveness of the rule-based testing paradigm. The prototype consists of five parts: the test data generator, the parser/scanner, the test coverage analyzer, a symbolic evaluator, and a data management facility, known as the Librarian. These components are discussed at length. Also presented is an experimental design for the evaluations, an overview of the project, and a schedule for its completion.

  18. ADA (Trade Name) Software Engineering Education and Training Symposium (2nd) Held in Dallas, Texas on 9-11 June 1987.

    DTIC Science & Technology

    1987-06-11

    now exist. If managers are made aware of how Ada based technology can be used to develop quality and cost effective software products, they will be... based on an analysis of individual needs. Software engineers must be cognizant of related methods and maintain an awareness of current and new efforts in...Karyl Adams, Air Force Institute of Technology Lessons Learned in Using Formal Specification Techniques in ............... 79 an Ada- based Software

  19. Association of G22A and A4223C ADA1 gene polymorphisms and ADA activity with PCOS.

    PubMed

    Salehabadi, Mahshid; Farimani, Marzieh; Tavilani, Heidar; Ghorbani, Marzieh; Poormonsefi, Faranak; Poorolajal, Jalal; Shafiei, Gholamreza; Ghasemkhani, Neda; Khodadadi, Iraj

    2016-06-01

    Adenosine deaminase-1 (ADA1) regulates the concentration of adenosine as the main modulator of oocyte maturation. There is compelling evidence for the association of ADA1 gene polymorphisms with many diseases but the importance of ADA1 polymorphisms in polycystic ovary syndrome (PCOS) has not been studied before. This study investigates serum total ADA activity (tADA), ADA1 and ADA2 isoenzyme activities, and genotype and allele frequencies of G22A and A4223C polymorphisms in healthy and PCOS women. In this case-control study 200 PCOS patients and 200 healthy women were enrolled. Genomic DNA was extracted from whole blood and the PCR-RFLP technique was used to determine the G22A and A4223C variants. The genotype frequencies were calculated and the association between polymorphic genotypes and enzyme activities were determined. tADA activity was significantly lower in the PCOS group compared with the control group (27.76±6.0 vs. 39.63±7.48, respectively). PCOS patients also showed reduced activity of ADA1 and ADA2. PCOS was not associated with G22A polymorphism whereas AA, AC, and CC genotypes of A4223C polymorphism were found distributed differently between the control and the PCOS women where the C allele showed a strong protective role for PCOS (odds ratio=1.876, p=0.033). The present study for the first time showed that lower ADA activity may be involved in pathogenesis of PCOS by maintaining a higher concentration of adenosine affecting follicular growth. As a novel finding, we also showed great differences in genotype distribution and allele frequencies of A4223C polymorphism between groups indicating a protective role for C allele against PCOS. AbbreviationsADA: adenosine deaminase PCOS: polycystic ovary syndrome PCR-RFLP: polymerase chain reaction-restriction fragment length polymorphism tADA: total adenosine deaminase.

  20. Restoring balance to B cells in ADA deficiency.

    PubMed

    Luning Prak, Eline T

    2012-06-01

    It is paradoxical that immunodeficiency disorders are associated with autoimmunity. Adenosine deaminase (ADA) deficiency, a cause of X-linked severe combined immunodeficiency (SCID), is a case in point. In this issue of the JCI, Sauer and colleagues investigate the B cell defects in ADA-deficient patients. They demonstrate that ADA patients receiving enzyme replacement therapy had B cell tolerance checkpoint defects. Remarkably, gene therapy with a retrovirus that expresses ADA resulted in the apparent correction of these defects, with normalization of peripheral B cell autoantibody frequencies. In vitro, agents that either block ADA or overexpress adenosine resulted in altered B cell receptor and TLR signaling. Collectively, these data implicate a B cell-intrinsic mechanism for alterations in B cell tolerance in the setting of partial ADA deficiency that is corrected by gene therapy.

  1. ART/Ada design project, phase 1: Project plan

    NASA Technical Reports Server (NTRS)

    Allen, Bradley P.

    1988-01-01

    The plan and schedule for Phase 1 of the Ada based ESBT Design Research Project is described. The main platform for the project is a DEC Ada compiler on VAX mini-computers and VAXstations running the Virtual Memory System (VMS) operating system. The Ada effort and lines of code are given in tabular form. A chart is given of the entire project life cycle.

  2. Software engineering and the role of Ada: Executive seminar

    NASA Technical Reports Server (NTRS)

    Freedman, Glenn B.

    1987-01-01

    The objective was to introduce the basic terminology and concepts of software engineering and Ada. The life cycle model is reviewed. The application of the goals and principles of software engineering is applied. An introductory understanding of the features of the Ada language is gained. Topics addressed include: the software crises; the mandate of the Space Station Program; software life cycle model; software engineering; and Ada under the software engineering umbrella.

  3. Towards a formal semantics for Ada 9X

    NASA Technical Reports Server (NTRS)

    Guaspari, David; Mchugh, John; Wolfgang, Polak; Saaltink, Mark

    1995-01-01

    The Ada 9X language precision team was formed during the revisions of Ada 83, with the goal of analyzing the proposed design, identifying problems, and suggesting improvements, through the use of mathematical models. This report defines a framework for formally describing Ada 9X, based on Kahn's 'natural semantics', and applies the framework to portions of the language. The proposals for exceptions and optimization freedoms are also analyzed, using a different technique.

  4. Ada (Tradename) Compiler Validation Summary Report. Symbolics, Inc., Symbolics Ada, Version 1.0. Symbolics 3600.

    DTIC Science & Technology

    1986-06-11

    foo.a.b.c ........ An illegal extiernal file name that either contains invalid characters or is too long. $FILE NAME WITH WILD CARD CHAR "eno: >testing...ada>-tests>c*.." An extiernal file name that either contains a wild card character or is too long. $GREATER THAN DURATION 864~01.0 A univeral real value

  5. Assessment of the Ada (Trade Name) Validation Process.

    DTIC Science & Technology

    1985-12-01

    Sincerely,’ Warren Berger Intermetr±os, Inc. Ada Systems Division733 Concord Ave Cambridge, MA 02146 (617) 661-1840 ’C-79 Arpanet: ima!inmet!ada-uts!wkb...Warren Berger S Intermetrics, Inc. Ada Systems Division 733 Concord Ave I Cambridge, MA 02146 (617) 661-1840 Arpanet: imalinmetiada-utsiwkb@CCA-UNIX.ARPA...MA 02146 (617) 661-1840 Arpanet: ima!inmetiada-uts wkb@CCA-UNIX.ARPA -- CA5004B-B.ADA -- CHECK THAT PRAGMA ELABORATE IS ACCEPTED AND OBEYED EVEN IF

  6. ADA (adenosine deaminase) gene therapy enters the competition

    SciTech Connect

    Culliton, B.J.

    1990-08-31

    Around the world, some 70 children are members of a select and deadly club. Born with an immune deficiency so severe that they will die of infection unless their immune systems can be repaired, they have captured the attention of would-be gene therapists who believe that a handful of these kids--the 15 or 20 who lack functioning levels of the enzyme adenosine deaminase (ADA)--could be saved by a healthy ADA gene. A team of gene therapists is ready to put the theory to the test. In April 1987, a team of NIH researchers headed by R. Michael Blaese and W. French Anderson came up with the first formal protocol to introduce a healthy ADA gene into an unhealthy human. After 3 years of line-by-line scrutiny by five review committees, they have permission to go ahead. Two or three children will be treated in the next year, and will be infused with T lymphocytes carrying the gene for ADA. If the experiment works, the ADA gene will begin producing normal amounts of ADA. An interesting feature of ADA deficiency, that makes it ideal for initial gene studies, is that the amount of ADA one needs for a healthy immune system is quite variable. Hence, once inside a patient's T cells, the new ADA gene needs only to express the enzyme in moderate amounts. No precise gene regulation is necessary.

  7. Implementation of a production Ada project: The GRODY study

    NASA Technical Reports Server (NTRS)

    Godfrey, Sara; Brophy, Carolyn Elizabeth

    1989-01-01

    The use of the Ada language and design methodologies that encourage full use of its capabilities have a strong impact on all phases of the software development project life cycle. At the National Aeronautics and Space Administration/Goddard Space Flight Center (NASA/GSFC), the Software Engineering Laboratory (SEL) conducted an experiment in parallel development of two flight dynamics systems in FORTRAN and Ada. The differences observed during the implementation, unit testing, and integration phases of the two projects are described and the lessons learned during the implementation phase of the Ada development are outlined. Included are recommendations for future Ada development projects.

  8. Transferring data objects: A focused Ada investigation

    NASA Technical Reports Server (NTRS)

    Legrand, Sue

    1988-01-01

    The use of the Ada language does not guarantee that data objects will be in the same form or have the same value after they have been stored or transferred to another system. There are too many possible variables in such things as the formats used and other protocol conditions. Differences may occur at many different levels of support. These include program level, object level, application level, and system level. A standard language is only one aspect of making a complex system completely homogeneous. Many components must be standardized and the various standards must be integrated. The principal issues in providing for interaction between systems are of exchanging files and data objects between systems which may not be compatible in terms of their host computer, operating system or other factors. A typical resolution of the problem of invalidating data involves at least a common external form, for data objects and for representing the relationships and attributes of data collections. Some of the issues dealing with the transfer of data are listed and consideration is given on how these issues may be handled in the Ada language.

  9. Ada and the rapid development lifecycle

    NASA Technical Reports Server (NTRS)

    Deforrest, Lloyd; Gref, Lynn

    1991-01-01

    JPL is under contract, through NASA, with the US Army to develop a state-of-the-art Command Center System for the US European Command (USEUCOM). The Command Center System will receive, process, and integrate force status information from various sources and provide this integrated information to staff officers and decision makers in a format designed to enhance user comprehension and utility. The system is based on distributed workstation class microcomputers, VAX- and SUN-based data servers, and interfaces to existing military mainframe systems and communication networks. JPL is developing the Command Center System utilizing an incremental delivery methodology called the Rapid Development Methodology with adherence to government and industry standards including the UNIX operating system, X Windows, OSF/Motif, and the Ada programming language. Through a combination of software engineering techniques specific to the Ada programming language and the Rapid Development Approach, JPL was able to deliver capability to the military user incrementally, with comparable quality and improved economies of projects developed under more traditional software intensive system implementation methodologies.

  10. Ada (Trade Name) Complier Validation Summary Report: Verdix Ada Development System, Version 5.2 for the Sequent Balance under DYNIX, Release 1.3.2.

    DTIC Science & Technology

    1985-11-15

    ADAP B4 2 -B.DA B5001AAB-DA A54BO2A-B.ADA P B54A21A-B.ADA P B57001A-BADA P A55ISO2A- ABADA P B54A25BA-ADA P B5T001B-B.ADA P A55Bl3A-AB.ADA P B54A27B...B91001B-AB.ADA P B950BAA-B.ADA P C92003A.ADA P B91001C-AB.ADA P B950DHA-B.ADA P C92OAJA-B.ADA P B91001D- ABADA P B96002A-B.ADA P C920BAA-B.ADA P *B91001E...TESTS AND RESULTS Chapter 11 660 BB201A-k.AD P C100A- ABADA P CB003-kB.DA 82002A-AB.ADA P CB1003A-AB.ADA P CB4003A-B.ADA P BB2003A-AB.ADA P CB200IIA

  11. 49 CFR 37.125 - ADA paratransit eligibility: Process.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 1 2013-10-01 2013-10-01 false ADA paratransit eligibility: Process. 37.125... paratransit eligibility: Process. Each public entity required to provide complementary paratransit service by § 37.121 of this part shall establish a process for determining ADA paratransit eligibility. (a)...

  12. Artificial Intelligence in ADA: Pattern-Directed Processing. Final Report.

    ERIC Educational Resources Information Center

    Reeker, Larry H.; And Others

    To demonstrate to computer programmers that the programming language Ada provides superior facilities for use in artificial intelligence applications, the three papers included in this report investigate the capabilities that exist within Ada for "pattern-directed" programming. The first paper (Larry H. Reeker, Tulane University) is…

  13. Alma Flor Ada and the Quest for Change

    ERIC Educational Resources Information Center

    Manna, Anthony, L.; Hill, Janet; Kellogg, Kathy

    2004-01-01

    Alma Flor Ada, a folklorist, novelist, scholar, teacher, and children's book author has passionate dedication to education for social justice, equality, and peace. As a faculty member at the University of San Francisco, Ada has developed programs that help students and others transform their lives and has written several bilingual legends and…

  14. A Practical Guide to the ADA and Visual Impairment.

    ERIC Educational Resources Information Center

    Joffee, Elga

    Designed to be used as a companion to the Americans with Disabilities Act (ADA), this guide provides information on how the law applies to individuals with visual impairments. Section 1, "The ADA and Visual Impairment," gives an overview of the Americans with Disabilities Act and discusses visual impairment and accessibility. Examples of…

  15. 59 FR- Realty Action; Ada and Owyhee, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    1994-05-03

    ...-332A-02; IDI-29516] Realty Action; Ada and Owyhee, ID AGENCY: Bureau of Land Management, Interior. ACTION: Notice of Realty Action--IDI-29516; Exchange of public and private lands in Ada and Owyhee.... Containing 640 acres, more or less, in Owyhee County. The purpose of this exchange is to dispose of...

  16. The ADA and IDEA Basics: Inclusion of Children with Disabilities

    ERIC Educational Resources Information Center

    Motwani, Mona

    2007-01-01

    This article discusses the American with Disabilities Act (ADA) and the Individuals with Disabilities Education Act (IDEA). The ADA is a federal civil rights law that was passed in 1990 with the aim of securing equal rights for persons with disabilities in the employment, housing, government, transportation, and public accommodation contexts. It…

  17. A design for a reusable Ada library

    NASA Technical Reports Server (NTRS)

    Litke, John D.

    1986-01-01

    A goal of the Ada language standardization effort is to promote reuse of software, implying the existence of substantial software libraries and the storage/retrieval mechanisms to support them. A searching/cataloging mechanism is proposed that permits full or partial distribution of the database, adapts to a variety of searching mechanisms, permits a changine taxonomy with minimal disruption, and minimizes the requirement of specialized cataloger/indexer skills. The important observation is that key words serve not only as indexing mechanism, but also as an identification mechanism, especially via concatenation and as support for a searching mechanism. By deliberately separating these multiple uses, the modifiability and ease of growth that current libraries require, is achieved.

  18. Service dogs, psychiatric hospitalization, and the ADA.

    PubMed

    Muramatsu, Russ S; Thomas, Kelly Jones; Leong, Stephanie L; Ragukonis, Frank

    2015-01-01

    A service dog is defined as "any dog that is individually trained to do work or perform tasks for the benefit of an individual with a disability, including a physical, sensory, psychiatric, intellectual, or other mental disability." Some psychiatric patients may depend on a service dog for day-to-day functioning. The Americans with Disabilities Act (ADA) established certain rights and responsibilities for individuals with disabilities and health care providers. Psychiatric hospitalization of a patient with a service dog may pose a problem and involves balancing the requirement to provide safe and appropriate psychiatric care with the rights of individuals with disabilities. This Open Forum examines issues that arise in such circumstances, reviews the literature, and provides a foundation for the development of policies and procedures.

  19. Advances in gene therapy for ADA-deficient SCID.

    PubMed

    Aiuti, Alessandro

    2002-10-01

    Adenosine deaminase (ADA)-deficient severe combined immunodeficiency (SCID) was the first inherited disease treated with gene therapy. The pilot gene therapy studies demonstrated the safety, therapeutic potential and limitations of ADA gene transfer into hematopoietic cells using retroviral vectors. This review describes the latest progress in ADA-SCID dinical trials using peripheral blood lymphocytes (PBLs) and hematopoietic stem cells (HSCs). PBL gene therapy was able to restore T-cell functions after discontinuation of ADA enzyme replacement therapy, but only partially corrected the purine metabolic defect. The development of improved HSC gene transfer protocols, combined with low intensity conditioning, allowed full correction of the immunological and metabolic ADA defects, with clinic benefit. These results have important implications for future applications of gene therapy in other disorders involving the hemapoietic system.

  20. Simulation of the space station information system in Ada

    NASA Technical Reports Server (NTRS)

    Spiegel, James R.

    1986-01-01

    The Flexible Ada Simulation Tool (FAST) is a discrete event simulation language which is written in Ada. FAST has been used to simulate a number of options for ground data distribution of Space Station payload data. The fact that Ada language is used for implementation has allowed a number of useful interactive features to be built into FAST and has facilitated quick enhancement of its capabilities to support new modeling requirements. General simulation concepts are discussed, and how these concepts are implemented in FAST. The FAST design is discussed, and it is pointed out how the used of the Ada language enabled the development of some significant advantages over classical FORTRAN based simulation languages. The advantages discussed are in the areas of efficiency, ease of debugging, and ease of integrating user code. The specific Ada language features which enable these advances are discussed.

  1. Ada (Tradename) Compiler Validation Summary Report. Digital Equipment Corporation VAX Ada VI.3.

    DTIC Science & Technology

    1986-11-07

    Summary Report: 7 NOV 1986 to 7 NOV 1987 Digital Equipmont Corp. VAX Ada Vl.3 6. PERFORMING ORG . REPORT NUMBER 7. AUTHOR(s) 8. CONTRACT OR GRANT NUMBER(s...the identifiers TIME or SPA-CE as the single arg,:ent. I lhi< ragma is only allowed within a d,. iara !ive part and it applies to the block or body

  2. ADA 9X project report: ADA 9X requirements document. Draft report

    SciTech Connect

    Not Available

    1990-08-27

    This document contains a distillation of requests for language changes submitted by the general public and from special workshops held to identify potential areas for revision. The purpose of this document is to specify needs that are considered to be the appropriate focus of the Ada 9X revision effort and to identify revision requirements that are to be satisfied by the Mapping/Revision Team.

  3. Its Ada: An Intelligent Tutoring System for the ADA Programming Language

    DTIC Science & Technology

    1991-12-01

    interchange programs and programmers and virtually impossible for effective software maintenance (Sammet, 1986, p. 722). In 1975, at the request of DoD...for a Xerox machine exclusively. PROUST receives a complete program produced by the student as input for diagnosis and prints out a comprehensive bug... printed on the screen, the student will be placed directly into the editor to write Ada code in response to the • pic problem just presented. The editing

  4. Translation and execution of distributed Ada programs - Is it still Ada?

    NASA Technical Reports Server (NTRS)

    Volz, Richard A.; Mudge, Trevor N.; Buzzard, Gregory D.; Krishnan, Padmanabhan

    1987-01-01

    Some of the fundamental issues and tradeoffs for distributed execution systems for the Ada language are examined. Steps that need to be taken to deal with heterogeneity of addressing program objects, of processing resources, and of the individual processor environment are considered. The ways in which program elements can be assigned are examined in the context of four issues: implied remote object access, object visibility and recursive execution, task termination problems, and distributed types.

  5. Ada (Trade Name) Compiler Validation Summary Report: Verdix Corporation Verdix Ada Development System, Version 5.2 for the Tektronix 6130 under UTek, Release 2.1.1.

    DTIC Science & Technology

    1985-11-16

    AB.ADA P C64103A-B.ADA P C67003B-B.ADA P D- 12 %7I COMPLETE LIST OF TESTS AND RESULTS C67003C- ABADA P D64OO5FOM C D64005GD C V C67003D-BADA P D64005FA C...P C100 - ABADA P CB003-AB.DA BB2002A-AB.ADA P CB1003A-AB.ADA P CB1IOO3A-B.ADA P BB2003A-AB.ADA P CB2004A-B.ADA P CB4005A-B.ADA P BB2003A-AB.ADA P

  6. First International Conference on Ada (R) Programming Language Applications for the NASA Space Station, volume 1

    NASA Technical Reports Server (NTRS)

    Bown, Rodney L. (Editor)

    1986-01-01

    Topics discussed include: test and verification; environment issues; distributed Ada issues; life cycle issues; Ada in Europe; management/training issues; common Ada interface set; and run time issues.

  7. Ada Compiler Validation Summary Report: Certificate Number: 890919W1. 10156 R. R. Software, Inc., Janus/ADA, Version 2.1.3 Zenith Z-386/25.

    DTIC Science & Technology

    1989-09-19

    Compiler Validation Summary Repcrt, Ada Cor piler Validation Capability, ACVC, Validation Testing, Ada Validation Office, AVO , Ada Validation Facility...results of the validation tesiing performed on an Ada compiler. Testing was carried out for the following purposes: • To attempt to identify any language...the Ada Validation Organization ( AVO ). On-site testing was completed 19 September 1989 at Madison WI. 1.2 USE OF THIS VALIDATION SUMMARY REPORT

  8. ART/Ada design project, phase 1. Task 1 report: Overall design

    NASA Technical Reports Server (NTRS)

    Allen, Bradley P.

    1988-01-01

    The design methodology for the ART/Ada project is introduced, and the selected design for ART/Ada is described in detail. The following topics are included: object-oriented design, reusable software, documentation techniques, impact of Ada, design approach, and differences between ART-IM 1.5 and ART/Ada 1.0 prototype. Also, Ada generator and ART/Ada runtime systems are discussed.

  9. IDA and the Technical Cooperation Program Real-Time Systems and Ada Workshop, 21-23 June 1988

    DTIC Science & Technology

    1988-06-01

    Deputy Under Secretary of Defense RAM Random Access Memory R&AT Reasearch and Advance Technology RISC Reduced Instruction Set Computer SE1 Software...D-,dz Ada Information Clearing House 3D139 1211 S. Fern St. (C107) Pentagon Washington, D.C. 20301 (703) 694-0211 jbatz@ajpo.sei.cmu.edu Ms. Mary

  10. A proposed classification scheme for Ada-based software products

    NASA Technical Reports Server (NTRS)

    Cernosek, Gary J.

    1986-01-01

    As the requirements for producing software in the Ada language become a reality for projects such as the Space Station, a great amount of Ada-based program code will begin to emerge. Recognizing the potential for varying levels of quality to result in Ada programs, what is needed is a classification scheme that describes the quality of a software product whose source code exists in Ada form. A 5-level classification scheme is proposed that attempts to decompose this potentially broad spectrum of quality which Ada programs may possess. The number of classes and their corresponding names are not as important as the mere fact that there needs to be some set of criteria from which to evaluate programs existing in Ada. An exact criteria for each class is not presented, nor are any detailed suggestions of how to effectively implement this quality assessment. The idea of Ada-based software classification is introduced and a set of requirements from which to base further research and development is suggested.

  11. Ada and software management in NASA: Symposium/forum

    NASA Technical Reports Server (NTRS)

    1989-01-01

    The promises of Ada to improve software productivity and quality, and the claims that a transition to Ada would require significant changes in NASA's training programs and ways of doing business were investigated. The study assesses the agency's ongoing and planned Ada activities. A series of industry representatives (Computer Sciences Corporation, General Electric Aerospace, McDonnell Douglas Space Systems Company, TRW, Lockheed, and Boeing) reviewed the recommendations and assessed their impact from the Company's perspective. The potential effects on NASA programs were then discussed.

  12. Integrity and security in an Ada runtime environment

    NASA Technical Reports Server (NTRS)

    Bown, Rodney L.

    1991-01-01

    A review is provided of the Formal Methods group discussions. It was stated that integrity is not a pure mathematical dual of security. The input data is part of the integrity domain. The group provided a roadmap for research. One item of the roadmap and the final position statement are closely related to the space shuttle and space station. The group's position is to use a safe subset of Ada. Examples of safe sets include the Army Secure Operating System and the Penelope Ada verification tool. It is recommended that a conservative attitude is required when writing Ada code for life and property critical systems.

  13. Applications of an architecture design and assessment system (ADAS)

    NASA Technical Reports Server (NTRS)

    Gray, F. Gail; Debrunner, Linda S.; White, Tennis S.

    1988-01-01

    A new Architecture Design and Assessment System (ADAS) tool package is introduced, and a range of possible applications is illustrated. ADAS was used to evaluate the performance of an advanced fault-tolerant computer architecture in a modern flight control application. Bottlenecks were identified and possible solutions suggested. The tool was also used to inject faults into the architecture and evaluate the synchronization algorithm, and improvements are suggested. Finally, ADAS was used as a front end research tool to aid in the design of reconfiguration algorithms in a distributed array architecture.

  14. Software Engineering Laboratory (SEL) Ada performance study report

    NASA Technical Reports Server (NTRS)

    Booth, Eric W.; Stark, Michael E.

    1991-01-01

    The goals of the Ada Performance Study are described. The methods used are explained. Guidelines for future Ada development efforts are given. The goals and scope of the study are detailed, and the background of Ada development in the Flight Dynamics Division (FDD) is presented. The organization and overall purpose of each test are discussed. The purpose, methods, and results of each test and analyses of these results are given. Guidelines for future development efforts based on the analysis of results from this study are provided. The approach used on the performance tests is discussed.

  15. Ada (trademark) Compiler Validation Summary Report. Verdix Ada Compiler, VADS, Version V03.06 for VAX-11/785, Using ULTRIX 1.0.

    DTIC Science & Technology

    1985-06-14

    CCA207AOM C L3 04- ABADA /A A300B1 CA2007AOM C LA3004A-ABD N/A LA3007B2 C CA2007A1 C LA3004AO-AB N/A LA3007B2 C CA2007A2 C LA3004A2-AB N/A LA3007B4 C...B.ADA P CC3120B-B.ADA P CC3504A-B.ADA PI.BC3503B-B.ADA P CC32A-B.ADA P CC3504B-B.ADA P BC3503D-B.ADA P CC3203A- ABADA P CC3504C-B.ADA P BC3503D-B.ADA P

  16. Molecular basis for paradoxical carriers of adenosine deaminase (ADA) deficiency that show extremely low levels of ADA activity in peripheral blood cells without immunodeficiency.

    PubMed

    Ariga, T; Oda, N; Sanstisteban, I; Arredondo-Vega, F X; Shioda, M; Ueno, H; Terada, K; Kobayashi, K; Hershfield, M S; Sakiyama, Y

    2001-02-01

    Adenosine deaminase (ADA) deficiency causes an autosomal recessive form of severe combined immunodeficiency and also less severe phenotypes, depending to a large degree on genotype. In general, ADA activity in cells of carriers is approximately half-normal. Unexpectedly, healthy first-degree relatives of two unrelated ADA-deficient severe combined immunodeficient patients (mother and brother in family I; mother in family II) had only 1-2% of normal ADA activity in PBMC, lower than has previously been found in PBMC of healthy individuals with so-called "partial ADA deficiency." The level of deoxyadenosine nucleotides in erythrocytes of these paradoxical carriers was slightly elevated, but much lower than levels found in immunodeficient patients with ADA deficiency. ADA activity in EBV-lymphoblastoid cell lines (LCL) and T cell lines established from these carriers was 10-20% of normal. Each of these carriers possessed two mutated ADA alleles. Expression of cloned mutant ADA cDNAs in an ADA-deletion strain of Escherichia coli indicated that the novel mutations G239S and M310T were responsible for the residual ADA activity. ADA activity in EBV-LCL extracts of the paradoxical carriers was much more labile than ADA from normal EBV-LCL. Immunoblotting suggested that this lability was due to denaturation rather than to degradation of the mutant protein. These results further define the threshold level of ADA activity necessary for sustaining immune function.

  17. Ada (trade name) Compiler Validation Summary Report. Verdix Corporation Verdix Ada Development System, Version 5.2 for the VAX-11/750 under VMS V4.1. Completion of On-Site Validation: 17 Novemember 1985.

    DTIC Science & Technology

    1985-11-17

    AB.ADA P *C52104L- ABADA P C55B04A-AB.ADA P C58006B-AB.ADA P *C52104KABAD P C55B05A -ADA P C59001B-A.D P C521OLIP-AB.ADA P C55B06A-AB.ADA P C59002A-AB.ADA...P B97103D-AB.ADA P C9�B-B.ADA P B91OACA-B.ADA P B97103E- ABADA P C94003A-B.ADA P B910AEA-B.ADA P B9710’IA-AB.ADA P C94IOO4A-B.ADA P *B91OBCA-B.ADA

  18. QUEST/Ada (Query Utility Environment for Software Testing of Ada): The development of a prgram analysis environment for Ada, task 1, phase 2

    NASA Technical Reports Server (NTRS)

    Brown, David B.

    1990-01-01

    The results of research and development efforts are described for Task one, Phase two of a general project entitled The Development of a Program Analysis Environment for Ada. The scope of this task includes the design and development of a prototype system for testing Ada software modules at the unit level. The system is called Query Utility Environment for Software Testing of Ada (QUEST/Ada). The prototype for condition coverage provides a platform that implements expert system interaction with program testing. The expert system can modify data in the instrument source code in order to achieve coverage goals. Given this initial prototype, it is possible to evaluate the rule base in order to develop improved rules for test case generation. The goals of Phase two are the following: (1) to continue to develop and improve the current user interface to support the other goals of this research effort (i.e., those related to improved testing efficiency and increased code reliable); (2) to develop and empirically evaluate a succession of alternative rule bases for the test case generator such that the expert system achieves coverage in a more efficient manner; and (3) to extend the concepts of the current test environment to address the issues of Ada concurrency.

  19. A report on NASA software engineering and Ada training requirements

    NASA Technical Reports Server (NTRS)

    Legrand, Sue; Freedman, Glenn B.; Svabek, L.

    1987-01-01

    NASA's software engineering and Ada skill base are assessed and information that may result in new models for software engineering, Ada training plans, and curricula are provided. A quantitative assessment which reflects the requirements for software engineering and Ada training across NASA is provided. A recommended implementation plan including a suggested curriculum with associated duration per course and suggested means of delivery is also provided. The distinction between education and training is made. Although it was directed to focus on NASA's need for the latter, the key relationships to software engineering education are also identified. A rationale and strategy for implementing a life cycle education and training program are detailed in support of improved software engineering practices and the transition to Ada.

  20. The development of a program analysis environment for Ada

    NASA Technical Reports Server (NTRS)

    Brown, David B.; Carlisle, Homer W.; Chang, Kai-Hsiung; Cross, James H.; Deason, William H.; Haga, Kevin D.; Huggins, John R.; Keleher, William R. A.; Starke, Benjamin B.; Weyrich, Orville R.

    1989-01-01

    A unit level, Ada software module testing system, called Query Utility Environment for Software Testing of Ada (QUEST/Ada), is described. The project calls for the design and development of a prototype system. QUEST/Ada design began with a definition of the overall system structure and a description of component dependencies. The project team was divided into three groups to resolve the preliminary designs of the parser/scanner: the test data generator, and the test coverage analyzer. The Phase 1 report is a working document from which the system documentation will evolve. It provides history, a guide to report sections, a literature review, the definition of the system structure and high level interfaces, descriptions of the prototype scope, the three major components, and the plan for the remainder of the project. The appendices include specifications, statistics, two papers derived from the current research, a preliminary users' manual, and the proposal and work plan for Phase 2.

  1. Interesting viewpoints to those who will put Ada into practice

    NASA Technical Reports Server (NTRS)

    Carlsson, Arne

    1986-01-01

    Ada will most probably be used as the programming language for computers in the NASA Space Station. It is reasonable to suppose that Ada will be used for at least embedded computers, because the high software costs for these embedded computers were the reason why Ada activities were initiated about ten years ago. The on-board computers are designed for use in space applications, where maintenance by man is impossible. All manipulation of such computers has to be performed in an autonomous way or remote with commands from the ground. In a manned Space Station some maintenance work can be performed by service people on board, but there are still a lot of applications, which require autonomous computers, for example, vital Space Station functions and unmanned orbital transfer vehicles. Those aspect which have come out of the analysis of Ada characteristics together with the experience of requirements for embedded on-board computers in space applications are examined.

  2. The Adam language: Ada extended with support for multiway activities

    NASA Technical Reports Server (NTRS)

    Charlesworth, Arthur

    1993-01-01

    The Adam language is an extension of Ada that supports multiway activities, which are cooperative activities involving two or more processes. This support is provided by three new constructs: diva procedures, meet statements, and multiway accept statements. Diva procedures are recursive generic procedures having a particular restrictive syntax that facilitates translation for parallel computers. Meet statements and multiway accept statements provide two ways to express a multiway rendezvous, which is an n-way rendezvous generalizing Ada's 2-way rendezvous. While meet statements tend to have simpler rules than multiway accept statements, the latter approach is a more straightforward extension of Ada. The only nonnull statements permitted within meet statements and multiway accept statements are calls on instantiated diva procedures. A call on an instantiated diva procedure is also permitted outside a multiway rendezvous; thus sequential Adam programs using diva procedures can be written. Adam programs are translated into Ada programs appropriate for use on parallel computers.

  3. In vivo transduction by intravenous injection of a lentiviral vector expressing human ADA into neonatal ADA gene knockout mice: a novel form of enzyme replacement therapy for ADA deficiency.

    PubMed

    Carbonaro, Denise A; Jin, Xiangyang; Petersen, Denise; Wang, Xingchao; Dorey, Fred; Kil, Ki Soo; Aldrich, Melissa; Blackburn, Michael R; Kellems, Rodney E; Kohn, Donald B

    2006-06-01

    Using a mouse model of adenosine deaminase-deficient severe combined immune deficiency syndrome (ADA-deficient SCID), we have developed a noninvasive method of gene transfer for the sustained systemic expression of human ADA as enzyme replacement therapy. The method of delivery is a human immunodeficiency virus 1-based lentiviral vector given systemically by intravenous injection on day 1 to 2 of life. In this article we characterize the biodistribution of the integrated vector, the expression levels of ADA enzyme activity in various tissues, as well as the efficacy of systemic ADA expression to correct the ADA-deficient phenotype in this mouse model. The long-term expression of enzymatically active ADA achieved by this method, primarily from transduction of liver and lung, restored immunologic function and significantly extended survival. These studies illustrate the potential for sustained in vivo production of enzymatically active ADA, as an alternative to therapy by frequent injection of exogenous ADA protein.

  4. GRASP/Ada: Graphical Representations of Algorithms, Structures, and Processes for Ada. The development of a program analysis environment for Ada: Reverse engineering tools for Ada, task 2, phase 3

    NASA Technical Reports Server (NTRS)

    Cross, James H., II

    1991-01-01

    The main objective is the investigation, formulation, and generation of graphical representations of algorithms, structures, and processes for Ada (GRASP/Ada). The presented task, in which various graphical representations that can be extracted or generated from source code are described and categorized, is focused on reverse engineering. The following subject areas are covered: the system model; control structure diagram generator; object oriented design diagram generator; user interface; and the GRASP library.

  5. Benchmarking Ada tasking on tightly coupled multiprocessor architectures

    NASA Technical Reports Server (NTRS)

    Collard, Philippe; Goforth, Andre; Marquardt, Matthew

    1989-01-01

    The development of benchmarks and performance measures for parallel Ada tasking is reported with emphasis on the macroscopic behavior of the benchmark across a set of load parameters. The application chosen for the study was the NASREM model for telerobot control, relevant to many NASA missions. The results of the study demonstrate the potential of parallel Ada in accomplishing the task of developing a control system for a system such as the Flight Telerobotic Servicer using the NASREM framework.

  6. Methodology Study for Real-Time Ada Problems

    DTIC Science & Technology

    1989-03-24

    very highly, even though this was seemingly not that important a feature theoretically (see figure 2). The most popular tools were those that automated ...of the availability and maturity of automated software tools which implement an Ada-oriented software method. The issue of availability involves the...oriented: The PAMELA methodology automates the process of moving from symbology to Ada coding. This stabilizes the coding step of the development

  7. Compiling knowledge-based systems specified in KEE to Ada

    NASA Technical Reports Server (NTRS)

    Filman, Robert E.; Feldman, Roy D.

    1991-01-01

    The first year of the PrKAda project is recounted. The primary goal was to develop a system for delivering Artificial Intelligence applications developed in the ProKappa system in a pure-Ada environment. The following areas are discussed: the ProKappa core and ProTalk programming language; the current status of the implementation; the limitations and restrictions of the current system; and the development of Ada-language message handlers in the ProKappa environment.

  8. Evaluation of Ada as a Communications Programming Language.

    DTIC Science & Technology

    1981-03-31

    drastically, altered or circumvented to provide a communicatin system with sufficient resources to operate at a required level of performance. 3.3.1.2...Command (CORADCO4) and standard Digital Equipment Corporation VAX 11/780 system * software. Plans include the hosting of Ada/ED on the VAX 11/780 at the... Corporation , Bedford, MA, August, 1978. b. /LOGl79a/ LOGICON, "Formal Specification of GUARD Trusted Software (Draft)," ARPA-78C032303, September, 1979

  9. Ada Compiler Validation Summary Report: Certificate Number 89020W1. 10073: International Business Machines Corporation, IBM Development System for the Ada Language, VM/CMS Ada Compiler, Version 2.1.1, IBM 3083 (Host and Target)

    DTIC Science & Technology

    1989-04-20

    International Business Machines Corporation) IBM Development System for the Ada Language, VN11/CMS Ada Compiler, Version 2.1.1, Wright-Patterson AFB, IBM 3083...890420W1.10073 International Business Machines Corporation IBM Development System for the Ada Language VM/CMS Ada Compiler Version 2.1.1 IBM 3083... International Business Machines Corporation and reviewed by the validation team. The compiler was tested using all default option settings except for the

  10. Ada Compiler Validation Summary Report: Certificate Number: 890420W1. 10066 International Business Machines Corporation, IBM Development System for the Ada Language, AIX/RT Ada Compiler, Version 1.1.1, IBM RT PC 6150-125

    DTIC Science & Technology

    1989-04-20

    International Business Machines Corporation, IBM Development System. for the Ada Language AIX/RT Ada Compiler, Version 1.1.1, Wright-Patterson APB...Certificate Number: 890420V1.10066 International Business Machines Corporation IBM Development System for the Ada Language AIX/RT Ada Compiler, Version 1.1.1...TEST INFORMATION The compiler was tested using command scripts provided by International Business Machines Corporation and reviewed by the validation

  11. Hydraulic Capacity of an ADA Compliant Street Drain Grate

    SciTech Connect

    Lottes, Steven A.; Bojanowski, Cezary

    2015-09-01

    Resurfacing of urban roads with concurrent repairs and replacement of sections of curb and sidewalk may require pedestrian ramps that are compliant with the American Disabilities Act (ADA), and when street drains are in close proximity to the walkway, ADA compliant street grates may also be required. The Minnesota Department of Transportation ADA Operations Unit identified a foundry with an available grate that meets ADA requirements. Argonne National Laboratory’s Transportation Research and Analysis Computing Center used full scale three dimensional computational fluid dynamics to determine the performance of the ADA compliant grate and compared it to that of a standard vane grate. Analysis of a parametric set of cases was carried out, including variation in longitudinal, gutter, and cross street slopes and the water spread from the curb. The performance of the grates was characterized by the fraction of the total volume flow approaching the grate from the upstream that was captured by the grate and diverted into the catch basin. The fraction of the total flow entering over the grate from the side and the fraction of flow directly over a grate diverted into the catch basin were also quantities of interest that aid in understanding the differences in performance of the grates. The ADA compliant grate performance lagged that of the vane grate, increasingly so as upstream Reynolds number increased. The major factor leading to the performance difference between the two grates was the fraction of flow directly over the grates that is captured by the grates.

  12. Programming in a proposed 9X distributed Ada

    NASA Technical Reports Server (NTRS)

    Waldrop, Raymond S.; Volz, Richard A.; Goldsack, Stephen J.; Holzbach-Valero, A. A.

    1991-01-01

    The studies of the proposed Ada 9X constructs for distribution, now referred to as AdaPT are reported. The goals for this time period were to revise the chosen example scenario and to begin studying about how the proposed constructs might be implemented. The example scenario chosen is the Submarine Combat Information Center (CIC) developed by IBM for the Navy. The specification provided by IBM was preliminary and had several deficiencies. To address these problems, some changes to the scenario specification were made. Some of the more important changes include: (1) addition of a system database management function; (2) addition of a fourth processing unit to the standard resources; (3) addition of an operator console interface function; and (4) removal of the time synchronization function. To implement the CIC scenario in AdaPT, the decided strategy were publics, partitions, and nodes. The principle purpose for implementing the CIC scenario was to demonstrate how the AdaPT constructs interact with the program structure. While considering ways that the AdaPt constructs might be translated to Ada 83, it was observed that the partition construct could reasonably be modeled as an abstract data type. Although this gives a useful method of modeling partitions, it does not at all address the configuration aspects on the node construct.

  13. Examining the reliability of ADAS-Cog change scores.

    PubMed

    Grochowalski, Joseph H; Liu, Ying; Siedlecki, Karen L

    2016-09-01

    The purpose of this study was to estimate and examine ways to improve the reliability of change scores on the Alzheimer's Disease Assessment Scale, Cognitive Subtest (ADAS-Cog). The sample, provided by the Alzheimer's Disease Neuroimaging Initiative, included individuals with Alzheimer's disease (AD) (n = 153) and individuals with mild cognitive impairment (MCI) (n = 352). All participants were administered the ADAS-Cog at baseline and 1 year, and change scores were calculated as the difference in scores over the 1-year period. Three types of change score reliabilities were estimated using multivariate generalizability. Two methods to increase change score reliability were evaluated: reweighting the subtests of the scale and adding more subtests. Reliability of ADAS-Cog change scores over 1 year was low for both the AD sample (ranging from .53 to .64) and the MCI sample (.39 to .61). Reweighting the change scores from the AD sample improved reliability (.68 to .76), but lengthening provided no useful improvement for either sample. The MCI change scores had low reliability, even with reweighting and adding additional subtests. The ADAS-Cog scores had low reliability for measuring change. Researchers using the ADAS-Cog should estimate and report reliability for their use of the change scores. The ADAS-Cog change scores are not recommended for assessment of meaningful clinical change.

  14. Proceedings of the third international IEEE conference on Ada applications and environments

    SciTech Connect

    Not Available

    1988-01-01

    These proceedings collect papers on software applications. Topics include: An interleaving symbolic execution approach for the formal verification of Ada programs with tasking, fault-tolerant Ada software, object-oriented frameworks for Ada, and generating multitasking Ada programs from high-level specifications.

  15. 77 FR 65438 - In the Matter of China Voice Holding Corp., China Yongxin Pharmaceuticals, Inc., Creative...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-26

    ... Technologies Holdings, Inc., Crestek, Inc., Crys*Tel Telecommunications.com , Inc. (n/k/a Fleet Management Solutions, Inc.), CSI Computer Specialists, Inc., and CST Entertainment, Inc. (n/k/a Legacy Holding, Inc... Technologies Holdings, Inc. because it has not filed any periodic reports since the period ended March 31,...

  16. Cougar Holdings, LLC Information Sheet

    EPA Pesticide Factsheets

    Cougar Holdings, LLC (the Company) is located in Colorado Springs, Colorado. The settlement involves renovation activities conducted at a property constructed prior to 1978, located in Denver, Colorado.

  17. Using Ada to implement the operations management system in a community of experts

    NASA Technical Reports Server (NTRS)

    Frank, M. S.

    1986-01-01

    An architecture is described for the Space Station Operations Management System (OMS), consisting of a distributed expert system framework implemented in Ada. The motivation for such a scheme is based on the desire to integrate the very diverse elements of the OMS while taking maximum advantage of knowledge based systems technology. Part of the foundation of an Ada based distributed expert system was accomplished in the form of a proof of concept prototype for the KNOMES project (Knowledge-based Maintenance Expert System). This prototype successfully used concurrently active experts to accomplish monitoring and diagnosis for the Remote Manipulator System. The basic concept of this software architecture is named ACTORS for Ada Cognitive Task ORganization Scheme. It is when one considers the overall problem of integrating all of the OMS elements into a cooperative system that the AI solution stands out. By utilizing a distributed knowledge based system as the framework for OMS, it is possible to integrate those components which need to share information in an intelligent manner.

  18. Bibliography of Journal Holdings

    DTIC Science & Technology

    1988-06-01

    Abstract iournal of metallurgy (1958)-(1963) Part B. Technology of metals Academie Polonaise des Sciences. V.18 (1970)- Bulletin (Maths, astronom et ...V.18 (1966) Aeronautique et lastronautique (1969)-(1986) Aeroplane. Incorporated in Flight V.71 (1946)- imperfect international from December 1968...ATandT Bell laboratories tachi , al journal Bibliography on industrial diamond V.6 (1949)- imperfect applications. Title changed to V.14 (1957

  19. ART/Ada design project, phase 1. Task 3 report: Test plan

    NASA Technical Reports Server (NTRS)

    Allen, Bradley P.

    1988-01-01

    The plan is described for the integrated testing and benchmark of Phase Ada based ESBT Design Research Project. The integration testing is divided into two phases: (1) the modules that do not rely on the Ada code generated by the Ada Generator are tested before the Ada Generator is implemented; and (2) all modules are integrated and tested with the Ada code generated by the Ada Generator. Its performance and size as well as its functionality is verified in this phase. The target platform is a DEC Ada compiler on VAX mini-computers and VAX stations running the VMS operating system.

  20. AdaNET phase 0 support for the AdaNET Dynamic Software Inventory (DSI) management system prototype. Catalog of available reusable software components

    NASA Technical Reports Server (NTRS)

    Hanley, Lionel

    1989-01-01

    The Ada Software Repository is a public-domain collection of Ada software and information. The Ada Software Repository is one of several repositories located on the SIMTEL20 Defense Data Network host computer at White Sands Missile Range, and available to any host computer on the network since 26 November 1984. This repository provides a free source for Ada programs and information. The Ada Software Repository is divided into several subdirectories. These directories are organized by topic, and their names and a brief overview of their topics are contained. The Ada Software Repository on SIMTEL20 serves two basic roles: to promote the exchange and use (reusability) of Ada programs and tools (including components) and to promote Ada education.

  1. Ada Compiler Validation Summary Report: Certificate Number: 880524I1. 09118 Systeam KG Systeam Ada Compiler VAX/VMS Version 1.8 VAX 8530 (Host and Target)

    DTIC Science & Technology

    1988-05-24

    Validation Summary Report, Ada Compiler Validation Capability, ACVC, Validation Testing, Ada Validation Office, AVO , Ada Validation Facility, AVF, ANSI...administered by the Ada Validation Organization ( AVO ). On-site testing was completed 88-05-24 at SYSTEAM KG at Karlsruhe. 1.2 USE OF THIS VALIDATION...SUMMARY REPORT Consistent with the national laws of the originating country, the AVO may make full and free public disclosure of this report. in the United

  2. Health care under the ADA: a vision or a mirage?

    PubMed

    Mudrick, Nancy R; Schwartz, Michael A

    2010-10-01

    Problems in health care access are identified using recent studies documenting the health disparities experienced by people with disabilities. Some of these health care access barriers qualify as discrimination prohibited under the Americans with Disabilities Act. Focusing on the past decade of ADA enforcement, issues reported in the U.S. Department of Justice listing of resolved ADA complaints and settlements are compared to the profile of access problems. Key court case outcomes of the past decade also are presented. These sources indicate that the majority of resolved complaints and settlements involved failure to provide effective communication (often sign language interpretation). A smaller percentage of complaints and settlements addressed issues of refusal to provide treatment, physical access, equipment access, and provider procedures. Most of the key settlements involved hospitals and larger provider organizations, while many complaints also focused on individual physicians. Although the record indicates that the ADA can be, and has been, effectively used to increase access in many instances, other types of access problems have been lightly addressed through application of the ADA. This likely stems from enforcement choices made by the Department of Justice and the dynamics of the patient-doctor relationship. The broad challenge for the coming decade is to develop means to achieve effective communication and eliminate physical and programmatic barriers in more health care provider settings more consistently. The ADA can be a vigorous force in this effort as part of a multipronged strategy.

  3. Ada (Trade Name) Compiler Validation Summary Report: Verdix Corporation Verdix Ada Development System, Version 5.2 for the CCI Power 6/32 under Power 6 UNIX, Release 1.11.

    DTIC Science & Technology

    1986-11-16

    AB.ADA P- B 54A20A.ADA P B56001H-AB.ADA P C52103G-AB.ADA P D- 10 COMPLETE LIST OF TESTS AND RESULTS C5213H-A.AD P C4AOA- ABADA p C5002-AB.DA C52103H...B91001A-AB.ADA P B95OAJA-B.ADA P C92002A-.ADA P B91001C-AB.ADA P B95ODHA-B.ADA P C92O0A-.ADA P B91OO1D- ABADA P B950BAA-B.ADA P C92OBA.ADA P B91001E-AB.ADA P

  4. Toward real-time performance benchmarks for Ada

    NASA Technical Reports Server (NTRS)

    Clapp, Russell M.; Duchesneau, Louis; Volz, Richard A.; Mudge, Trevor N.; Schultze, Timothy

    1986-01-01

    The issue of real-time performance measurements for the Ada programming language through the use of benchmarks is addressed. First, the Ada notion of time is examined and a set of basic measurement techniques are developed. Then a set of Ada language features believed to be important for real-time performance are presented and specific measurement methods discussed. In addition, other important time related features which are not explicitly part of the language but are part of the run-time related features which are not explicitly part of the language but are part of the run-time system are also identified and measurement techniques developed. The measurement techniques are applied to the language and run-time system features and the results are presented.

  5. Can space station software be specified through Ada?

    NASA Technical Reports Server (NTRS)

    Knoebel, Arthur

    1987-01-01

    Programming of the space station is to be done in the Ada programming language. A breadboard of selected parts of the work package for Marshall Space Flight Center is to be built, and programming this small part will be a good testing ground for Ada. One coding of the upper levels of the design brings out several problems with top-down design when it is to be carried out strictly within the language. Ada is evaluated on the basis of this experience, and the points raised are compared with other experience as related in the literature. Rapid prototyping is another approach to the initial programming; several different types of prototypes are discussed, and compared with the art of specification. Some solutions are proposed and a number of recommendations presented.

  6. Transparent Ada rendezvous in a fault tolerant distributed system

    NASA Technical Reports Server (NTRS)

    Racine, Roger

    1986-01-01

    There are many problems associated with distributing an Ada program over a loosely coupled communication network. Some of these problems involve the various aspects of the distributed rendezvous. The problems addressed involve supporting the delay statement in a selective call and supporting the else clause in a selective call. Most of these difficulties are compounded by the need for an efficient communication system. The difficulties are compounded even more by considering the possibility of hardware faults occurring while the program is running. With a hardware fault tolerant computer system, it is possible to design a distribution scheme and communication software which is efficient and allows Ada semantics to be preserved. An Ada design for the communications software of one such system will be presented, including a description of the services provided in the seven layers of an International Standards Organization (ISO) Open System Interconnect (OSI) model communications system. The system capabilities (hardware and software) that allow this communication system will also be described.

  7. An automated quality assessor for Ada object-oriented designs

    NASA Technical Reports Server (NTRS)

    Bailin, Sidney C.

    1988-01-01

    A tool for evaluating object-oriented designs (OODs) for Ada software is described. The tool assumes a design expressed as a hierarchy of object diagrams. A design of this type identifies the objects of a system, an interface to each object, and the usage relationships between objects. When such a design is implemented in Ada, objects become packages, interfaces become package specifications, and usage relationships become Ada `with' clauses and package references. An automated quality assessor has been developed that is based on flagging undesirable design constructs. For convenience, distinctions are made among three levels of severity: questionable, undesirable, and hazardous. A questionable construct is one that may well be appropriate. An undesirable construct is one that should be changed because it is potentially harmful to the reliability, maintainability, or reusability of the software. A hazardous construct is one that is undesirable and that introduces a high level of risk.

  8. The development of a program analysis environment for Ada: Reverse engineering tools for Ada. Final Report, 1 Jun. 1990 - 30 Sep. 1991

    SciTech Connect

    Cross, J.H. II.

    1991-09-01

    The Graphical Representations of Algorithms, Structures, and Processes for Ada (GRASP/Ada) has successfully created and prototyped a new algorithm level graphical representation for Ada software, the Control Structure Diagram (CSD). The primary impetus for creation of the CSD was to improve the comprehension efficiency of Ada software and thus improve reliability and reduce costs. The emphasis was on the automatic generation of the CSD from Ada source code to support reverse engineering and maintenance. The CSD has the potential to replace traditional prettyprinted Ada source code. In Phase 1 of the GRASP/Ada project, the CSD graphical constructs were created and applied manually to several small Ada programs. A prototype (Version 1) was designed and implemented using FLEX and BISON running under the Virtual Memory System (VMS) on a VAX 11-780. In Phase 2, the prototype was improved and ported to the Sun 4 platform under UNIX. A user interface was designed and partially implemented. The prototype was applied successfully to numerous Ada programs ranging in size from several hundred to several thousand lines of source code. In Phase 3 of the project, the prototype was prepared for limited distribution (GRASP/Ada Version 3.0) to facilitate evaluation. The user interface was extensively reworked. The current prototype provides the capability for the user to generate CSD from Ada source code in a reverse engineering mode with a level of flexibility suitable for practical application.

  9. Ada compiler validation summary report: Cray Research, Inc. , Cray Ada Compiler, Version 1. 1 Cray X-MP (Host Target), 890523W1. 10080

    SciTech Connect

    Not Available

    1989-05-23

    This Validation Summary Report describes the extent to which a specific Ada compiler conforms to the Ada Standard, ANSI/MIL-STD-1815A. The report explains all technical terms used within it and thoroughly reports the results of testing this compiler using the Ada Compiler Validation Capability. An Ada compiler must be implemented according to the Ada Standard, and any implementation-dependent features must conform to the requirements of the Ada Standard. The Ada Standard must be implemented in its entirety, and nothing can be implemented that is not in the Standard. Even though all validated Ada compilers conform to the Ada Standard, it must be understood that some differences do exist between implementations. The Ada Standard permits some implementation dependencies - for example, the maximum length of identifiers or the maximum values of integer types. Other differences between compilers result from the characteristics of particular operating systems, hardware, or implementation strategies. All the dependencies observed during the process of testing this compiler are given in this report. The information in this report is derived from the test results produced during validation testing. The validation process includes submitting a suite of standardized tests, the ACVC, as inputs to an Ada compiler and evaluating the results.

  10. Ada compiler validation summary report. Cray Research, Inc. , Cray Ada Compiler, Version 1. 1, Cray-2, (Host Target), 890523W1. 10081

    SciTech Connect

    Not Available

    1989-05-23

    This Validation Summary Report describes the extent to which a specific Ada compiler conforms to the Ada Standard, ANSI-MIL-STD-1815A. The report explains all technical terms used within it and thoroughly reports the results of testing this compiler using the Ada Compiler Validation Capability. An Ada compiler must be implemented according to the Ada Standard, and any implementation-dependent features must conform to the requirements of the Ada Standard. The Ada Standard must be implemented in its entirety, and nothing can be implemented that is not in the Standard. Even though all validated Ada compilers conform to the Ada Standard, it must be understood that some differences do exist between implementations. The Ada Standard permits some implementation dependencies - for example, the maximum length of identifiers or the maximum values of integer types. Other differences between compilers result from the characteristics of particular operating systems, hardware, or implementation strategies. All the dependencies observed during the process of testing this compiler are given in this report. The information in this report is derived from the test results produced during validation testing. The validation process includes submitting a suite of standardized tests, the ACVC, as inputs to an Ada compiler and evaluating the results.

  11. Bar-holding prosthetic limb

    NASA Technical Reports Server (NTRS)

    Vest, Thomas W. (Inventor); Norton, William E. (Inventor); Belcher, Jewell G. (Inventor); Carden, James R. (Inventor)

    1992-01-01

    A prosthetic device for below-the-elbow amputees is disclosed. The device has a removable effector, which is attached to the end of an arm cuff. The effector is comprised of a pair of C-shaped members that are oriented so as to face each other. Working in concert, the C-shaped members are able to hold a bar such as a chainsaw handle. A flat spring is fitted around the C-shaped members to hold them together.

  12. T-cell lines from 2 patients with adenosine deaminase (ADA) deficiency showed the restoration of ADA activity resulted from the reversion of an inherited mutation.

    PubMed

    Ariga, T; Oda, N; Yamaguchi, K; Kawamura, N; Kikuta, H; Taniuchi, S; Kobayashi, Y; Terada, K; Ikeda, H; Hershfield, M S; Kobayashi, K; Sakiyama, Y

    2001-05-01

    Inherited deficiency of adenosine deaminase (ADA) results in one of the autosomal recessive forms of severe combined immunodeficiency. This report discusses 2 patients with ADA deficiency from different families, in whom a possible reverse mutation had occurred. The novel mutations were identified in the ADA gene from the patients, and both their parents were revealed to be carriers. Unexpectedly, established patient T-cell lines, not B-cell lines, showed half-normal levels of ADA enzyme activity. Reevaluation of the mutations in these T-cell lines indicated that one of the inherited ADA gene mutations was reverted in both patients. At least one of the patients seemed to possess the revertant cells in vivo; however, the mutant cells might have overcome the revertant after receiving ADA enzyme replacement therapy. These findings may have significant implications regarding the prospects for stem cell gene therapy for ADA deficiency.

  13. GRASP/Ada (Graphical Representations of Algorithms, Structures, and Processes for Ada): The development of a program analysis environment for Ada. Reverse engineering tools for Ada, task 1, phase 2

    NASA Technical Reports Server (NTRS)

    Cross, James H., II

    1990-01-01

    The study, formulation, and generation of structures for Ada (GRASP/Ada) are discussed in this second phase report of a three phase effort. Various graphical representations that can be extracted or generated from source code are described and categorized with focus on reverse engineering. The overall goal is to provide the foundation for a CASE (computer-aided software design) environment in which reverse engineering and forward engineering (development) are tightly coupled. Emphasis is on a subset of architectural diagrams that can be generated automatically from source code with the control structure diagram (CSD) included for completeness.

  14. STGT program: Ada coding and architecture lessons learned

    NASA Technical Reports Server (NTRS)

    Usavage, Paul; Nagurney, Don

    1992-01-01

    STGT (Second TDRSS Ground Terminal) is currently halfway through the System Integration Test phase (Level 4 Testing). To date, many software architecture and Ada language issues have been encountered and solved. This paper, which is the transcript of a presentation at the 3 Dec. meeting, attempts to define these lessons plus others learned regarding software project management and risk management issues, training, performance, reuse, and reliability. Observations are included regarding the use of particular Ada coding constructs, software architecture trade-offs during the prototyping, development and testing stages of the project, and dangers inherent in parallel or concurrent systems, software, hardware, and operations engineering.

  15. Formal methods in the design of Ada 1995

    NASA Technical Reports Server (NTRS)

    Guaspari, David

    1995-01-01

    Formal, mathematical methods are most useful when applied early in the design and implementation of a software system--that, at least, is the familiar refrain. I will report on a modest effort to apply formal methods at the earliest possible stage, namely, in the design of the Ada 95 programming language itself. This talk is an 'experience report' that provides brief case studies illustrating the kinds of problems we worked on, how we approached them, and the extent (if any) to which the results proved useful. It also derives some lessons and suggestions for those undertaking future projects of this kind. Ada 95 is the first revision of the standard for the Ada programming language. The revision began in 1988, when the Ada Joint Programming Office first asked the Ada Board to recommend a plan for revising the Ada standard. The first step in the revision was to solicit criticisms of Ada 83. A set of requirements for the new language standard, based on those criticisms, was published in 1990. A small design team, the Mapping Revision Team (MRT), became exclusively responsible for revising the language standard to satisfy those requirements. The MRT, from Intermetrics, is led by S. Tucker Taft. The work of the MRT was regularly subject to independent review and criticism by a committee of distinguished Reviewers and by several advisory teams--for example, the two User/Implementor teams, each consisting of an industrial user (attempting to make significant use of the new language on a realistic application) and a compiler vendor (undertaking, experimentally, to modify its current implementation in order to provide the necessary new features). One novel decision established the Language Precision Team (LPT), which investigated language proposals from a mathematical point of view. The LPT applied formal mathematical analysis to help improve the design of Ada 95 (e.g., by clarifying the language proposals) and to help promote its acceptance (e.g., by identifying a

  16. Simulation in Ada; Proceedings of the Eastern Simulation Conference, Norfolk, VA, March 3-8, 1985

    SciTech Connect

    Unger, B.; Lomow, G.; Trybul, T.

    1985-01-01

    The development of ADA compilers in 1984 reached a stage that now permits the implementation of ADA-language-based simulators which can handle large programs. The conference covered topics such as automated Ada-based methodology simulator program development. Attention was also given to implementing a simulator as a set of Ada tasks and testing software for Ada language discrete simulation models. Attempts at developing a moving target, distributed, real-time simulation using Ada for studying jet engine performance are described. Finally, techniques for simulating parallel computational processes for optical control problems are contrasted with sequential optimization process performance.

  17. The development of an Ada programming support environment database: SEAD (Software Engineering and Ada Database), user's manual

    NASA Technical Reports Server (NTRS)

    Liaw, Morris; Evesson, Donna

    1988-01-01

    This is a manual for users of the Software Engineering and Ada Database (SEAD). SEAD was developed to provide an information resource to NASA and NASA contractors with respect to Ada-based resources and activities that are available or underway either in NASA or elsewhere in the worldwide Ada community. The sharing of such information will reduce the duplication of effort while improving quality in the development of future software systems. The manual describes the organization of the data in SEAD, the user interface from logging in to logging out, and concludes with a ten chapter tutorial on how to use the information in SEAD. Two appendices provide quick reference for logging into SEAD and using the keyboard of an IBM 3270 or VT100 computer terminal.

  18. 31 CFR 800.217 - Hold.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Hold. 800.217 Section 800.217 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF INVESTMENT... FOREIGN PERSONS Definitions § 800.217 Hold. The terms hold(s) and holding mean legal or...

  19. Ada as an implementation language for knowledge based systems

    NASA Technical Reports Server (NTRS)

    Rochowiak, Daniel

    1990-01-01

    Debates about the selection of programming languages often produce cultural collisions that are not easily resolved. This is especially true in the case of Ada and knowledge based programming. The construction of programming tools provides a desirable alternative for resolving the conflict.

  20. Section 504/ADA: Guidelines for Educators in Kansas. Revised.

    ERIC Educational Resources Information Center

    Miller, Joan; Bieker, Rod; Copenhaver, John

    This document presents the Kansas State Department of Education's guidelines to Section 504 of the Rehabilitation Act and the Americans with Disabilities Act (ADA). The guidelines specifically address Subparts A, B, C, and D of the regulations for Section 504 which deal with general provisions, employment practices, accessibility and education. An…

  1. The Impact of Business Size on Employer ADA Response

    ERIC Educational Resources Information Center

    Bruyere, Susanne M.; Erickson, William A.; VanLooy, Sara A.

    2006-01-01

    More than 10 years have passed since the employment provisions of the Americans with Disabilities Act of 1990 (ADA) came into effect for employers of 15 or more employees. Americans with disabilities continue to be more unemployed and underemployed than their nondisabled peers. Small businesses, with fewer than 500 employees, continue to be the…

  2. Rationale for the Design of the ADA (Tradename) Programming Language,

    DTIC Science & Technology

    1986-01-01

    Note that if the exception were propagated to the parent task, it would mean that child tasks could interfere asynchronously with their parent, and it...plethora of differently named procedures to cope with the demand for flexibilty in areas such as formatting. The approach taken in Ada lies between the two

  3. Ada Compiler Validation Summary Report: Certificate Number: 890420W1. 10075 International Business Machines Corporation. IBM Development System, for the Ada Language CMS/MVS Ada Cross Compiler, Version 2.1.1 IBM 3083 Host and IBM 4381 Target

    DTIC Science & Technology

    1989-04-20

    International business Machines Corporati,:i IBM Development System for the Ada Language, CMS/MVS Ada Cross Compiler, Version 2.1.1, Wright-Patterson AFB, IBM...VALIDATION SUMMARY REPORT: Certificate Number: 890420W1.10075 International Business Machines Corporation IBM Development System for the Ada Language CMS...command scripts provided by International Business Machines Corporation and reviewed by the validation team. The compiler was tested using all default

  4. Ada (Trade Name) Compiler Validation Summary Report: DDC Ada Compiler System Version 3.1 for DEC VAX-11/785.

    DTIC Science & Technology

    1985-12-27

    PB361O1A-AB.ADA P B38105A-AB.ADA P C35705K-.B.DEP P B36102A.ADA P B38105B- ABADA P C35705L-B.DEP N/A B36103A.ADA P B38106A-B.ADA P C357094-B.DEP N/A...aAB.ADA P C314OO1D.-B.DEP P C357O5T-.DEP N/A B36171G-AB-ADA P C3’IOO1E..B.DEP P C3570SU-aB.DEP N/AB36171H- ABADA P C34001F-B.DEP N/A C35705V-B.DEP N...AB361711.. ABADA P C3’IOO1G..D.DEP P C357O5W-B.DEP N/A B36201A-BADA P C34oo1H-B.ADA P C3570SX-B.DEP N/AB37003A-.AB.ADA P C3’IOO1I.B.ADA P C35705Y-B.DEP

  5. Flow cytometry analysis of adenosine deaminase (ADA) expression: a simple and reliable tool for the assessment of ADA-deficient patients before and after gene therapy.

    PubMed

    Otsu, Makoto; Hershfield, Michael S; Tuschong, Laura M; Muul, Linda M; Onodera, Masafumi; Ariga, Tadashi; Sakiyama, Yukio; Candotti, Fabio

    2002-02-10

    Clinical gene therapy trials for adenosine deaminase (ADA) deficiency have shown limited success of corrective gene transfer into autologous T lymphocytes and CD34(+) cells. In these trials, the levels of gene transduction and expression in hematopoietic cells have been assessed by DNA- or RNA-based assays and measurement of ADA enzyme activity. Although informative, these methods are rarely applied to clonal analysis. The results of these assays therefore provide best estimates of transduction efficiency and gene expression in bulk populations based on the assumption that gene transfer and expression are uniformly distributed among transduced cells. As a useful additional tool for evaluation of ADA gene expression, we have developed a flow cytometry (fluorescence-activated cell sorting, FACS) assay capable of estimating the levels of intracellular ADA on a single-cell basis. We validated this technique with T cell lines and peripheral blood mononuclear cells (PBMCs) from ADA-deficient patients that showed severely reduced levels of ADA expression (ADA-dull) by FACS and Western blot analyses. After retrovirus-mediated ADA gene transfer, these cells showed clearly distinguishable populations exhibiting ADA expression (ADA-bright), thus allowing estimation of transduction efficiency. By mixing ADA-deficient and normal cells and using enzymatic amplification, we determined that our staining procedure could detect as little as 5% ADA-bright cells. This technique, therefore, will be useful to quickly assess the expression of ADA in hematopoietic cells of severe combined immunodeficient patients and represents an important tool for the follow-up of patients treated in clinical gene transfer protocols.

  6. Ada (Trademark) Compiler Validation Summary Report: Symbolics Incorporated. Symbolics Ada Compiler, Version 2.0, Symbolics 3670.

    DTIC Science & Technology

    1987-05-20

    invalid characters exist. $FILENAME WITH WILD CARD CHAR "eno:>testing>ada>c-tests>c*.*. * " An external file name that either contains a wild card character...or is too long if no wild card character exists. $GREATERTHANDURATION 86_401.0 A universal real value that lies between DURATION’BASE’LAST and 10

  7. 76 FR 38129 - Applications for New Awards; Americans With Disabilities Act (ADA) National Network Knowledge...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-29

    ... Applications for New Awards; Americans With Disabilities Act (ADA) National Network Knowledge Translation... Rehabilitation Research Projects (DRRP)--The ADA National Network Knowledge Translation Center Notice inviting... April 28, 2006 (71 FR 25472). The ADA National Network Knowledge Translation Center priority is from...

  8. 78 FR 34095 - Adequacy Status of the Idaho, Northern Ada County PM10

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-06

    ... AGENCY Adequacy Status of the Idaho, Northern Ada County PM 10 State Implementation Plan for... 2023 in the Northern Ada County PM 10 State Implementation Plan, Maintenance Plan: Ten-Year Update... in Northern Ada County. The EPA's finding was made pursuant to the adequacy review process...

  9. 78 FR 10263 - Proposed Collection; Comment Request for ADA Accommodations Request Packet

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-13

    ... Internal Revenue Service Proposed Collection; Comment Request for ADA Accommodations Request Packet AGENCY... U.S.C. 3506(c)(2)(A)). Currently, the IRS is soliciting comments concerning the ADA Accommodations... through the Internet, at Martha.R.Brinson @irs.gov. SUPPLEMENTARY INFORMATION: Title: ADA...

  10. Formal verification and testing: An integrated approach to validating Ada programs

    NASA Technical Reports Server (NTRS)

    Cohen, Norman H.

    1986-01-01

    An integrated set of tools called a validation environment is proposed to support the validation of Ada programs by a combination of methods. A Modular Ada Validation Environment (MAVEN) is described which proposes a context in which formal verification can fit into the industrial development of Ada software.

  11. A graphically oriented specification language for automatic code generation. GRASP/Ada: A Graphical Representation of Algorithms, Structure, and Processes for Ada, phase 1

    NASA Technical Reports Server (NTRS)

    Cross, James H., II; Morrison, Kelly I.; May, Charles H., Jr.; Waddel, Kathryn C.

    1989-01-01

    The first phase of a three-phase effort to develop a new graphically oriented specification language which will facilitate the reverse engineering of Ada source code into graphical representations (GRs) as well as the automatic generation of Ada source code is described. A simplified view of the three phases of Graphical Representations for Algorithms, Structure, and Processes for Ada (GRASP/Ada) with respect to three basic classes of GRs is presented. Phase 1 concentrated on the derivation of an algorithmic diagram, the control structure diagram (CSD) (CRO88a) from Ada source code or Ada PDL. Phase 2 includes the generation of architectural and system level diagrams such as structure charts and data flow diagrams and should result in a requirements specification for a graphically oriented language able to support automatic code generation. Phase 3 will concentrate on the development of a prototype to demonstrate the feasibility of this new specification language.

  12. ELAPSE - NASA AMES LISP AND ADA BENCHMARK SUITE: EFFICIENCY OF LISP AND ADA PROCESSING - A SYSTEM EVALUATION

    NASA Technical Reports Server (NTRS)

    Davis, G. J.

    1994-01-01

    One area of research of the Information Sciences Division at NASA Ames Research Center is devoted to the analysis and enhancement of processors and advanced computer architectures, specifically in support of automation and robotic systems. To compare systems' abilities to efficiently process Lisp and Ada, scientists at Ames Research Center have developed a suite of non-parallel benchmarks called ELAPSE. The benchmark suite was designed to test a single computer's efficiency as well as alternate machine comparisons on Lisp, and/or Ada languages. ELAPSE tests the efficiency with which a machine can execute the various routines in each environment. The sample routines are based on numeric and symbolic manipulations and include two-dimensional fast Fourier transformations, Cholesky decomposition and substitution, Gaussian elimination, high-level data processing, and symbol-list references. Also included is a routine based on a Bayesian classification program sorting data into optimized groups. The ELAPSE benchmarks are available for any computer with a validated Ada compiler and/or Common Lisp system. Of the 18 routines that comprise ELAPSE, provided within this package are 14 developed or translated at Ames. The others are readily available through literature. The benchmark that requires the most memory is CHOLESKY.ADA. Under VAX/VMS, CHOLESKY.ADA requires 760K of main memory. ELAPSE is available on either two 5.25 inch 360K MS-DOS format diskettes (standard distribution) or a 9-track 1600 BPI ASCII CARD IMAGE format magnetic tape. The contents of the diskettes are compressed using the PKWARE archiving tools. The utility to unarchive the files, PKUNZIP.EXE, is included. The ELAPSE benchmarks were written in 1990. VAX and VMS are trademarks of Digital Equipment Corporation. MS-DOS is a registered trademark of Microsoft Corporation.

  13. Application of ADA1 as a new marker enzyme in sandwich ELISA to study the effect of adenosine on activated monocytes

    PubMed Central

    Liu, Chengqian; Skaldin, Maksym; Wu, Chengxiang; Lu, Yuanan; Zavialov, Andrey V.

    2016-01-01

    Enzyme-linked immunosorbent assay (ELISA) is a valuable technique to detect antigens in biological fluids. Horse radish peroxidase (HRP) is one of the most common enzymes used for signal amplification in ELISA. Despite new advances in technology, such as a large-scale production of recombinant enzymes and availability of new detection systems, limited research is devoted to finding alternative enzymes and their substrates to amplify the ELISA signals. Here, HRP-avidin was substituted with the human adenosine deaminase (hADA1)-streptavidin complex and adenosine as a detection system in commercial ELISA kits. The hADA1 ELISA was successfully used to demonstrate that adenosine, bound to A1 and A3 adenosine receptors, increases cytokine secretion by LPS activated monocytes. We show that hADA1-based ELISA has the same sensitivity, and also provides identical results, as HRP ELISA. In addition, the sensitivity of hADA1-based ELISA could be easily adjusted by changing the adenosine concentration and the incubation time. Therefore, hADA1 could be used as a detection enzyme with any commercial ELISA kit with a wide range of concentration of antigens. PMID:27510152

  14. Ada (Trade Name) Compiler Validation Summary Report: International Business Machines Corporation. IBM Development System for the Ada Language System, Version 1.1.0, IBM 4381 under MVS.

    DTIC Science & Technology

    1988-05-22

    TITLE (andSubtile) 5. TYPE OF REPORT & PERIOD COVERED Ada Compler Validation Summary Report: 22 May 1987 to 22 May 1988 International Business Machines...IBM Development System for the Ada Language System, Version 1.1.0, International Business Machines Corporation, Wright-Patterson AFB. IBM 4381 under...SUMMARY REPORT: International Business Machines Corporation IBM Development System f’or the Ada Language System, Version 1.1.0 IBM 4381 under MVS

  15. Ada Compiler Validation Summary Report: Certificate Number: 890621W1. 10105, Tandem Computers, Incorporated, Tandem Ada, Version T9270C30, Tandem NonStop VLX

    DTIC Science & Technology

    1989-06-21

    Validation Capability, ACVC, Validation Testing, Ada Validation Office, AVO , Ada Validation Facility, AVF, ANS1/F4’L-S7D- 1815A, Ada Joint PrograrM Office...by the Ada Validation Organization ( AVO ). On-site testing was completed 21 June 1989 at Cupertino CA. 1.2 USE OF THIS VALIDATION SUMMARY REPORT...Consistent with the national laws of the originating country, the AVO may make full and free public disclosure of this report. In the United States, this

  16. Fish Hold Effluent and Fish Hold Cleaning Wastewater Discharge

    DTIC Science & Technology

    2011-11-01

    commercial fishing vessels, and fish hold cleaning discharge samples from 9 vessels for their Study of Discharges Incidental to Normal Operation of...operate in US waters, representing the largest category of vessels in the Report to Congress: Study of Discharges Incidental to Normal Operation of...feet in length that fish the Bering Sea and the Gulf of Alaska for king crab (USEPA, 2010). During the 2010 Study of vessel discharges, EPA observed

  17. [Gene therapy for adenosine deaminase (ADA) deficiency: review of the past, the present and the future].

    PubMed

    Ariga, T

    2001-01-01

    ADA deficiency is the first disease being treated by gene therapy. Since the first trial of gene therapy performed ten years ago, more than 10 patients including our case with ADA deficiency have been treated by the gene therapy with different clinical protocols. In contrast to the recent successful report for X-SCID patients, however, no curative effect of gene therapy for ADA deficiency has been achieved at the moment. In this chapter, I would like to review the past, the present and the future of gene therapy for ADA deficiency, and discuss an issue, especially PEG-ADA therapy, regarding the prospect for stem cell gene therapy for the disease.

  18. The implementation and use of Ada on distributed systems with high reliability requirements

    NASA Technical Reports Server (NTRS)

    Knight, J. C.

    1986-01-01

    The use and implementation of Ada in distributed environments in which reliability is the primary concern were investigted. A distributed system, programmed entirely in Ada, was studied to assess the use of individual tasks without concern for the processor used. Continued development and testing of the fault tolerant Ada testbed; development of suggested changes to Ada to cope with the failures of interest; design of approaches to fault tolerant software in real time systems, and the integration of these ideas into Ada; and the preparation of various papers and presentations were discussed.

  19. Using AppletMagic(tm) to Implement an Orbit Propagator: New Life for Ada Objects

    NASA Technical Reports Server (NTRS)

    Stark, Michael E.

    1997-01-01

    This paper will discuss the use of the Intermetrics AppletMagic tool to build an applet to display a satellite ground track on a world map. This applet is the result of a prototype project that was developed by the Goddard Space Flight Center's Flight Dynamics Division (FDD), starting in June of 1996. Both Version 1 and Version 2 of this applet can be accessed via the URL http://fdd.gsfc.nasa.gov/Java.html. This paper covers Version 1, as Version 2 did not make radical changes to the Ada part of the applet. This paper will briefly describe the design of the applet, discuss the issues that arose during development, and will conclude with lessons learned and future plans for the FDD's use of Ada and Java. The purpose of this paper is to show examples of a successful project using Oi AppletMagic, and to highlight some of the pitfalls that occurred along the way. It is hoped that this discussion will be useful both to users of AppletMagic and to organizations such as Intermetrics that develop new technology.

  20. Generic Ada code in the NASA space station command, control and communications environment

    NASA Technical Reports Server (NTRS)

    Mcdougall, D. P.; Vollman, T. E.

    1986-01-01

    The results of efforts to apply powerful Ada constructs to the formatted message handling process are described. The goal of these efforts was to extend the state-of-technology in message handling while at the same time producing production-quality, reusable code. The first effort was initiated in September, 1984 and delivered in April, 1985. That product, the Generic Message Handling Facility, met initial goals, was reused, and is available in the Ada Repository on ARPANET. However, it became apparent during its development that the initial approach to building a message handler template was not optimal. As a result of this initial effort, several alternate approaches were identified, and research is now on-going to identify an improved product. The ultimate goal is to be able to instantly build a message handling system for any message format given a specification of that message format. The problem lies in how to specify the message format, and one that is done, how to use that information to build the message handler. Message handling systems and message types are described. The initial efforts, its results and its shortcomings are detailed. The approach now being taken to build a system which will be significantly easier to implement, and once implemented, easier to use, is described. Finally, conclusions are offered.

  1. 31 CFR 800.217 - Hold.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF INVESTMENT... FOREIGN PERSONS Definitions § 800.217 Hold. The terms hold(s) and holding mean legal or beneficial ownership, whether direct or indirect, whether through fiduciaries, agents, or other means....

  2. Plaintiff cannot sue under ADA if he seeks disability benefits.

    PubMed

    1996-08-23

    [Name removed] sued a New Jersey Disney store for AIDS discrimination under the Americans with Disabilities Act (ADA). At the same time, [name removed] applied for disability benefits. A U.S. Circuit Court of Appeals ruled that a plaintiff who applies for disability benefits is no longer a qualified individual with a disability and therefore cannot sue for employment discrimination under the Americans with Disabilities Act (ADA). Disney fired [name removed] on November 18, 1993, after he took $2 from the cash register to buy cigarettes. Confronted with the accusation, [name removed] told his supervisor he had AIDS. He was fired immediately. Although [name removed] alleged Disney used the $2 cash transaction as a pretext to fire him, a Federal judge said [name removed] was barred from suing because of the inconsistency between his statements on the disability applications and on the lawsuit.

  3. Administration and scoring variance on the ADAS-Cog.

    PubMed

    Connor, Donald J; Sabbagh, Marwan N

    2008-11-01

    The Alzheimer's Disease Assessment Scale - Cognitive (ADAS-Cog) is the most commonly used primary outcome instrument in clinical trials for treatments of dementia. Variations in forms, administration procedures and scoring rules, along with rater turnover and intra-rater drift may decrease the reliability of the instrument. A survey of possible variations in the ADAS-Cog was administered to 26 volunteer raters at a clinical trials meeting. Results indicate notable protocol variations in the forms used, administration procedures, and scoring rules. Since change over time is used to determine treatment effect in clinical trials, standardizing the instrument's ambiguities and addressing common problems will greatly increase the instrument's reliability and thereby enhance its sensitivity to treatment effects.

  4. Test Case Study: Estimating the Cost of Ada Software Development

    DTIC Science & Technology

    1989-04-01

    selected Navy data were used to develop the SASEr model (HEA89]. SASET is meant to be used to estimate development in Assembly, Ada, or any HOL. However...3-6 3.4 Criteria For Ratings Selection ........ 3-10 3.4.1 Normalization ..... ................. .. 3-11 3.4.2 Cunparison of Model Results...costing issues. The guiding principle for model selection for inclusion in the study was the availability of models to the AF=, USACEAC, and IITRI

  5. Insurance benefits under the ADA: Discrimination or business as usual?

    SciTech Connect

    McFadden, M.E.

    1993-12-31

    In December 1987, John McGann discovered he had AIDS. In July 1988, his employer altered his health insurance policy by reducing lifetime coverage for AIDS to $5,000, while maintaining the million-dollar limit for all other health conditions. The United States Court of Appeals for the Fifth Circuit upheld the employer`s right to make that change. The Supreme Court denied certiori. Public outcry was immediate and voluminous. The Solicitor General argued that the new Americans with Disabilities Act would save future John McGanns from the same treatment, but the validity of this optimistic prediction is yet to be determined. The Americans with Disabilities Act of 1990 (ADA) is landmark legislation that bars discrimination against the disabled in all aspects of employment, public services, and accommodations. The Act broadly defines disability to include illnesses such as AIDS and cancer, as well as limitations on mobility, vision, and hearing. The ADA indisputably creates a private cause of action for discrimination on the basis of disability. However, depending on the standard of review chosen by the federal courts, this cause of action may or may not provide much protection to those claiming discrimination on the basis of disability in employee benefits and insurance. This article discusses the ADA`s coverage of insurance and benefits in light of the possible standards courts might use to evaluate actions of parties in suits alleging discrimination in these areas and applies those standards of review to the facts of the McGann case. 146 refs.

  6. AN ADA LINEAR ALGEBRA PACKAGE MODELED AFTER HAL/S

    NASA Technical Reports Server (NTRS)

    Klumpp, A. R.

    1994-01-01

    This package extends the Ada programming language to include linear algebra capabilities similar to those of the HAL/S programming language. The package is designed for avionics applications such as Space Station flight software. In addition to the HAL/S built-in functions, the package incorporates the quaternion functions used in the Shuttle and Galileo projects, and routines from LINPAK that solve systems of equations involving general square matrices. Language conventions in this package follow those of HAL/S to the maximum extent practical and minimize the effort required for writing new avionics software and translating existent software into Ada. Valid numeric types in this package include scalar, vector, matrix, and quaternion declarations. (Quaternions are fourcomponent vectors used in representing motion between two coordinate frames). Single precision and double precision floating point arithmetic is available in addition to the standard double precision integer manipulation. Infix operators are used instead of function calls to define dot products, cross products, quaternion products, and mixed scalar-vector, scalar-matrix, and vector-matrix products. The package contains two generic programs: one for floating point, and one for integer. The actual component type is passed as a formal parameter to the generic linear algebra package. The procedures for solving systems of linear equations defined by general matrices include GEFA, GECO, GESL, and GIDI. The HAL/S functions include ABVAL, UNIT, TRACE, DET, INVERSE, TRANSPOSE, GET, PUT, FETCH, PLACE, and IDENTITY. This package is written in Ada (Version 1.2) for batch execution and is machine independent. The linear algebra software depends on nothing outside the Ada language except for a call to a square root function for floating point scalars (such as SQRT in the DEC VAX MATHLIB library). This program was developed in 1989, and is a copyrighted work with all copyright vested in NASA.

  7. The Definition of Production Quality Ada(trade name) Compiler.

    DTIC Science & Technology

    1987-03-20

    UNIT ELEMENT NO. INO. INO. ACCESSION NO. 11. TITLE (include Security Clasification ) The Definition of a Production Quality Ada Compiler 12. PERSONAL...DIVISION AIR FORCE SYSTEMS COMMAND Los Angeles Air Force Station P.O. Box 92960, Worldway Postal Center Los Angeles, CA 90009-2960 APPROVED FOR PUBLIC ...Department, Engineering Group. Mr. Giovanni Bargero, SD/ALR, approved the report for the Air Force. This report has been reviewed by the Public Affairs

  8. Understanding the Adoption of Ada: Results of an Industry Survey

    DTIC Science & Technology

    1990-05-01

    R& D ) expenditures of the participating firms were about $38 million with a standard error of $26 million. R& D expenditures represent an average of...5.3% of business unit revenues. An average of 28% of the R& D budget is spent on software development and 29% of the software research budget is...directed toward devel- oping Ada capabilities. Business unit R& D funds used for software development come from the following sources: ’A standard error is a

  9. Availability of Ada and C++ Compilers, Tools, Education and Training

    DTIC Science & Technology

    1991-07-01

    assembler languages of various sorts, C, and Fortran languages. Several provide an interface to Pascal and one to Cobol. The ability to import and export...program that runs on a different target platform. As an example, a Fortran or Pascal compiler running on a DEC VAX computer may produce output which...Ada, Pascal , Fortran, C++, PLI, and Jovial. The entire source code is not necessarily generated and some tools provide user- customizable templates that

  10. Chagas Parasite Detection in Blood Images Using AdaBoost

    PubMed Central

    Uc-Cetina, Víctor; Brito-Loeza, Carlos; Ruiz-Piña, Hugo

    2015-01-01

    The Chagas disease is a potentially life-threatening illness caused by the protozoan parasite, Trypanosoma cruzi. Visual detection of such parasite through microscopic inspection is a tedious and time-consuming task. In this paper, we provide an AdaBoost learning solution to the task of Chagas parasite detection in blood images. We give details of the algorithm and our experimental setup. With this method, we get 100% and 93.25% of sensitivity and specificity, respectively. A ROC comparison with the method most commonly used for the detection of malaria parasites based on support vector machines (SVM) is also provided. Our experimental work shows mainly two things: (1) Chagas parasites can be detected automatically using machine learning methods with high accuracy and (2) AdaBoost + SVM provides better overall detection performance than AdaBoost or SVMs alone. Such results are the best ones known so far for the problem of automatic detection of Chagas parasites through the use of machine learning, computer vision, and image processing methods. PMID:25861375

  11. Patient can't get ADA relief unless discrimination persists.

    PubMed

    1997-09-05

    Several United States courts have ruled that under Title III of the Americans with Disabilities Act (ADA), HIV-positive patients have no recourse against a physician who has discriminated against them, provided that the patients do not plan to visit the doctor in the future. If the patient states that he or she does not intend to use the physician's or facility's services again, there is no basis for injunctive relief under the ADA. This issue is illustrated by the case of [name removed], an HIV-positive patient residing in Atlanta, GA, who attempted to sue [name removed], a plastic surgeon who refused to perform a cosmetic implant procedure. [Name removed] claimed that the procedure was a direct threat to [name removed]'s health and refused to treat him. When [name removed] vowed that he would never again seek medical care from [name removed] he lost his opportunity to file suit against [name removed] under the ADA. Additionally, [name removed] did not prove that the cosmetic procedure would not pose a direct threat to his own health in the form of a postoperative infection. This position has been accepted by a number of courts, including [name removed] v. St. Helena Hospital (CA).

  12. Epitope characterization of the ADA response directed against a targeted immunocytokine.

    PubMed

    Stubenrauch, Kay; Künzel, Christian; Vogel, Rudolf; Tuerck, Dietrich; Schick, Eginhard; Heinrich, Julia

    2015-10-10

    Targeted immunocytokines (TICs) display potent activity in selective tumor suppression. This class of multi domain biotherapeutics (MDBs) is composed of the three major domains Fab, Fc, and a cytokine which may induce a complex polyclonal anti-drug antibody (ADA) response. However, classical ADA assays usually are not suitable to specify ADAs and to identify the immunogenic domains of a TIC. The purpose of the present study was to establish epitope characterization of ADA responses in order to specify immunogenic responses against a TIC and their direct impact on the pharmacokinetic profile, safety, and efficacy. Based on standard ADA screening and confirmation assays, respectively, domain detection assays (DDAs) and domain competition assays (DCAs) were established and compared by the use of 12 ADA-positive samples obtained from a cynomolgus monkey study in early development. Both domain-specific assays were sensitive enough to preserve the positive screening assay result and revealed an overall accordance for the evaluation of domain-specific ADA responses. About half of the samples displayed one ADA specificity, either for the Fab or for the cytokine (Cy) domain, and the remaining samples showed a combination of Fab-specific and Cy-specific ADA fractions. Fc-specific ADAs occurred in only one sample. In-depth comparison of DCAs and DDAs showed that both assays appeared to be appropriate to assess multi-specific ADA responses as well as minor ADA fractions. An advantage of DCAs is typically a fast and easy assay establishment, whereas, DDAs in some cases may be superior to assess low abundant ADAs in multi-specific responses. Our results reveal that both approaches benefit from thorough reagent development as an essential precondition for reliable epitope characterization of ADA responses.

  13. Alteration/deficiency in activation-3 (Ada3) plays a critical role in maintaining genomic stability

    PubMed Central

    Mirza, Sameer; Katafiasz, Bryan J.; Kumar, Rakesh; Wang, Jun; Mohibi, Shakur; Jain, Smrati; Gurumurthy, Channabasavaiah Basavaraju; Pandita, Tej K.; Dave, Bhavana J.; Band, Hamid; Band, Vimla

    2012-01-01

    Cell cycle regulation and DNA repair following damage are essential for maintaining genome integrity. DNA damage activates checkpoints in order to repair damaged DNA prior to exit to the next phase of cell cycle. Recently, we have shown the role of Ada3, a component of various histone acetyltransferase complexes, in cell cycle regulation, and loss of Ada3 results in mouse embryonic lethality. Here, we used adenovirus-Cre-mediated Ada3 deletion in Ada3fl/fl mouse embryonic fibroblasts (MEFs) to assess the role of Ada3 in DNA damage response following exposure to ionizing radiation (IR). We report that Ada3 depletion was associated with increased levels of phospho-ATM (pATM), γH2AX, phospho-53BP1 (p53BP1) and phospho-RAD51 (pRAD51) in untreated cells; however, radiation response was intact in Ada3−/− cells. Notably, Ada3−/− cells exhibited a significant delay in disappearance of DNA damage foci for several critical proteins involved in the DNA repair process. Significantly, loss of Ada3 led to enhanced chromosomal aberrations, such as chromosome breaks, fragments, deletions and translocations, which further increased upon DNA damage. Notably, the total numbers of aberrations were more clearly observed in S-phase, as compared with G₁ or G₂ phases of cell cycle with IR. Lastly, comparison of DNA damage in Ada3fl/fl and Ada3−/− cells confirmed higher residual DNA damage in Ada3−/− cells, underscoring a critical role of Ada3 in the DNA repair process. Taken together, these findings provide evidence for a novel role for Ada3 in maintenance of the DNA repair process and genomic stability. PMID:23095635

  14. The ADA Complex Is a Distinct Histone Acetyltransferase Complex in Saccharomyces cerevisiae

    PubMed Central

    Eberharter, Anton; Sterner, David E.; Schieltz, David; Hassan, Ahmed; Yates, John R.; Berger, Shelley L.; Workman, Jerry L.

    1999-01-01

    We have identified two Gcn5-dependent histone acetyltransferase (HAT) complexes from Saccharomyces cerevisiae, the 0.8-MDa ADA complex and the 1.8-MDa SAGA complex. The SAGA (Spt-Ada-Gcn5-acetyltransferase) complex contains several subunits which also function as part of other protein complexes, including a subset of TATA box binding protein-associated factors (TAFIIs) and Tra1. These observations raise the question of whether the 0.8-MDa ADA complex is a subcomplex of SAGA or whether it is a distinct HAT complex that also shares subunits with SAGA. To address this issue, we sought to determine if the ADA complex contained subunits that are not present in the SAGA complex. In this study, we report the purification of the ADA complex over 10 chromatographic steps. By a combination of mass spectrometry analysis and immunoblotting, we demonstrate that the adapter proteins Ada2, Ada3, and Gcn5 are indeed integral components of ADA. Furthermore, we identify the product of the S. cerevisiae gene YOR023C as a novel subunit of the ADA complex and name it Ahc1 for ADA HAT complex component 1. Biochemical functions of YOR023C have not been reported. However, AHC1 in high copy numbers suppresses the cold sensitivity caused by particular mutations in HTA1 (I. Pinto and F. Winston, personal communication), which encodes histone H2A (J. N. Hirschhorn et al., Mol. Cell. Biol. 15:1999–2009, 1995). Deletion of AHC1 disrupted the integrity of the ADA complex but did not affect SAGA or give rise to classic Ada− phenotypes. These results indicate that Gcn5, Ada2, and Ada3 function as part of a unique HAT complex (ADA) and represent shared subunits between this complex and SAGA. PMID:10490601

  15. Development and Demonstration of an Ada Test Generation System

    NASA Technical Reports Server (NTRS)

    1996-01-01

    In this project we have built a prototype system that performs Feasible Path Analysis on Ada programs: given a description of a set of control flow paths through a procedure, and a predicate at a program point feasible path analysis determines if there is input data which causes execution to flow down some path in the collection reaching the point so that tile predicate is true. Feasible path analysis can be applied to program testing, program slicing, array bounds checking, and other forms of anomaly checking. FPA is central to most applications of program analysis. But, because this problem is formally unsolvable, syntactic-based approximations are used in its place. For example, in dead-code analysis the problem is to determine if there are any input values which cause execution to reach a specified program point. Instead an approximation to this problem is computed: determine whether there is a control flow path from the start of the program to the point. This syntactic approximation is efficiently computable and conservative: if there is no such path the program point is clearly unreachable, but if there is such a path, the analysis is inconclusive, and the code is assumed to be live. Such conservative analysis too often yields unsatisfactory results because the approximation is too weak. As another example, consider data flow analysis. A du-pair is a pair of program points such that the first point is a definition of a variable and the second point a use and for which there exists a definition-free path from the definition to the use. The sharper, semantic definition of a du-pair requires that there be a feasible definition-free path from the definition to the use. A compiler using du-pairs for detecting dead variables may miss optimizations by not considering feasibility. Similarly, a program analyzer computing program slices to merge parallel versions may report conflicts where none exist. In the context of software testing, feasibility analysis plays an

  16. A Holding Function for Conflict Probe Appiications

    NASA Technical Reports Server (NTRS)

    McNally, Dave; Walton, Joe

    2004-01-01

    Conflict Alerts for aircraft in holding patterns are often missed or in error due to fact that holding trajectories are not modeled in Conflict Alert or Conflict Probe logic. In addition, a controller in one sector may not know when aircraft are holding in a neighboring sector. These factors can lead to an increased potential for loss of separation while aircraft are flying in holding patterns. A holding function for conflict probe applications has been developed and tested with air traffic data from Fort Worth Center. The holding function automatically determines when an aircraft enters a holding pattern, builds a holding region around the pattern and then probes the region for conflict with other traffic. The operational concept of use assumes that air traffic controllers are very busy during periods when aircraft are in holding and therefore don't have time to manually enter information which defines a holding pattern and activates conflict probing. For this reason, it is important the holding function automatically detect aircraft in holding and compute a holding region for conflict analysis. The controller is then alerted if other aircraft are predicted to fly through the holding region at the holding altitude.

  17. Ada (Trademark) Compiler Validation Summary Report: Telesoft Ada Compiler Version 2.0a6 for VAX-11/780, Using UNIX (Trademark) 4.2 BSD (Mt. Xinu).

    DTIC Science & Technology

    1985-02-05

    file name ending with .TST means the test depends on one or more of the implementation-dependent parameters listed in section 4.1. A h file name ending...B5800A- ABADA B5802A-BADA B58001A-AB..ADA P B58002CAB.ADA P B58003B-B.ADA P B58002C-AB.ADA P B58003A-B.ADA P B58001B-AB.ADA P B59001A-AB.ADA P B59001C

  18. Ada Compiler Validation Summary Report: R.R. Software, Inc., Janus/ADA, Version 2.1.3, IBM PS/2, Model 70-80386 (Host & Target) 890919W1.10158

    DTIC Science & Technology

    1989-09-19

    Capability, ACVC, Validation Testing, Ada Validation Office, AVO , Ada Validation Facility, AVF, A%.SI/.UL-STD- 1815A, Ada Joint Program Office, AJPO 20...the direction of the AVF according to procedures established by the Ada JQ.Int Program Office and administered by the Ada Validation Organization ( AVO ...originating country, the AVO may make full and free public disclosure of this report. In the United States, this is provided in accordance with the

  19. Ada (Trade name) Validation Summary Report: TeleSoft, Inc., TeleSoft Ada Compiler, Version 2.3C3 for the Gould CONCEPT/32 (Trade name) Model 6750 under MPX, Version 3.2. Completion of On-Site Validation.

    DTIC Science & Technology

    1985-12-06

    B.ADA P B62001E-B.ADA P C62003B-B.ADA P C65003A-B.ADA P B63006P-B.ADA P c63004A-AB.ADA P C65003B-B.ADA P B63005A- ABADA P C62006A-B.ADA P C66002DA...B.ADA P B63005B-AB.ADA P C63004A-AB.ADA P C66002C-AB.ADA P B63005A-AB.ADA P c6�B-B.ADA P C66002D- ABADA P% B63005B-AB.ADA P C64OO0IG-B.ADA P C66002E

  20. Lessons learned in creating spacecraft computer systems: Implications for using Ada (R) for the space station

    NASA Technical Reports Server (NTRS)

    Tomayko, James E.

    1986-01-01

    Twenty-five years of spacecraft onboard computer development have resulted in a better understanding of the requirements for effective, efficient, and fault tolerant flight computer systems. Lessons from eight flight programs (Gemini, Apollo, Skylab, Shuttle, Mariner, Voyager, and Galileo) and three reserach programs (digital fly-by-wire, STAR, and the Unified Data System) are useful in projecting the computer hardware configuration of the Space Station and the ways in which the Ada programming language will enhance the development of the necessary software. The evolution of hardware technology, fault protection methods, and software architectures used in space flight in order to provide insight into the pending development of such items for the Space Station are reviewed.

  1. Lessons learned applying CASE methods/tools to Ada software development projects

    NASA Technical Reports Server (NTRS)

    Blumberg, Maurice H.; Randall, Richard L.

    1993-01-01

    This paper describes the lessons learned from introducing CASE methods/tools into organizations and applying them to actual Ada software development projects. This paper will be useful to any organization planning to introduce a software engineering environment (SEE) or evolving an existing one. It contains management level lessons learned, as well as lessons learned in using specific SEE tools/methods. The experiences presented are from Alpha Test projects established under the STARS (Software Technology for Adaptable and Reliable Systems) project. They reflect the front end efforts by those projects to understand the tools/methods, initial experiences in their introduction and use, and later experiences in the use of specific tools/methods and the introduction of new ones.

  2. Polarization Radar Processing Technology

    DTIC Science & Technology

    1989-10-01

    Oi"C FILE ( J qII RADC-TR-89-144 In-House Report October 1989 AD-A215 242 POLARIZATION RADAR PROCESSING TECHNOLOGY Kenneth C. Stiefvater, Russell D...NO. NO. NO. ACCESSION NO. 62702F 4506 11 58 11. TITLE (Include Security Classification) POLARIZATION RADAR PROCESSING TECHNOLOGY 12. PERSONAL AUTHOR(S

  3. Ada (Trade Name) Compiler Validation Summary Report. ALSYS AlsyCOMP 001, Version 1.3, VAX-11/750 Host, Altos ACS 68000 14 Target.

    DTIC Science & Technology

    1985-11-08

    C5266Sr-A .ADA P 952004E-AD.DEP P D5ADIO-AB.ADA P C520e7A-B.ADA P 952806A-A .ADA P RS5Ae1 P-AR. ADA P C52008A-A .ADA P 853001A-AB.ADA p 855AO10- ABADA P...A9. ADA P D55AO3D-AB.ADA P C54Ae4A-AB.ADA P C55Ce2B-AB.ADA P D55AO3E-AB.ADA P C54Afl6A- ABADA P C55CO3A-AB.ADA P D55Ae3F-AB.ADA P C54AO7A-AB.ADA P... ABADA P C64665D- .ADA P C67e62E-S .ADA P 6)63009A-S. ADA P C$4Oe5D~u C C67003A- .ADA P 863699-. ADA P C64865DA C C6700398. ADA P 863069C- . ADA P

  4. Digital first order hold circuit

    NASA Technical Reports Server (NTRS)

    Chan, Fred N. (Inventor); Wensley, Gerald J. (Inventor)

    1989-01-01

    There is provided a digitally controlled first order hold circuit and waveform synthesizer for digitally controlling the representation of a function over an approximation interval. In accordance with the operation of the invention, the first order hold circuit and waveform generator receives a digital data input signal which contains initial condition data, up/down data, and slope data for the approximation interval. The initial condition data is loaded into an up/down counter which is incremented using counting data at a rate depending on the value of the slope data and in a direction depending on the value of the up-down data. In order to minimize delays arising from data acquistion, two frequency synthesizer circuits are provided such that one frequency synthesizer provides counting data while the other frequency synthesizer receives slope data. During alternating intervals, the other frequency synthesizer circuit provides counting data while the other circuit receives slope data. In addition, long length data input signals covering a plurality of approximation intervals are provided to reduce the demands on a main system central processing unit.

  5. Reference Manual for the Ada Programming Language. Proposed Standard Document

    DTIC Science & Technology

    1980-07-01

    be given in their pre.ence. Example of conflicting names in two packbges: procedure R is use TRAFFIC, WATERCOLORS ; -- subtypes used to resolve the...conflicting type name COLOR subtype TCOLOR is TRAFFIC.COLOR; subtype WCOLOR is WATERCOLORS.COLOR; SIGNAL T_COLOR; PAINT W COLOR; begin SIGNAL = GREEN...that of TF AFFIC PAINT = GREEN; - - that of W ,TERCOLORS end R; A Use C0auses 8.4 8-8 Ada Reference Manual Example of name identification with a use

  6. An Overview of Advanced Data Acquisition System (ADAS)

    NASA Technical Reports Server (NTRS)

    Mata, Carlos T.; Steinrock, T. (Technical Monitor)

    2001-01-01

    The paper discusses the following: 1. Historical background. 2. What is ADAS? 3. R and D status. 4. Reliability/cost examples (1, 2, and 3). 5. What's new? 6. Technical advantages. 7. NASA relevance. 8. NASA plans/options. 9. Remaining R and D. 10. Applications. 11. Product benefits. 11. Commercial advantages. 12. intellectual property. Aerospace industry requires highly reliable data acquisition systems. Traditional Acquisition systems employ end-to-end hardware and software redundancy. Typically, redundancy adds weight, cost, power consumption, and complexity.

  7. An approach to distributed execution of Ada programs

    NASA Technical Reports Server (NTRS)

    Volz, R. A.; Krishnan, P.; Theriault, R.

    1987-01-01

    Intelligent control of the Space Station will require the coordinated execution of computer programs across a substantial number of computing elements. It will be important to develop large subsets of these programs in the form of a single program which executes in a distributed fashion across a number of processors. A translation strategy for distributed execution of Ada programs in which library packages and subprograms may be distributed is described. A preliminary version of the translator is operational. Simple data objects (no records or arrays as yet), subprograms, and static tasks may be referenced remotely.

  8. Ada as a Hardware Description Language: An Initial Report

    DTIC Science & Technology

    2014-02-25

    language. We are not 1AdL is i tradomark Pf the US Goverment Ada Joint Projert cffice0i! :,:~~~~~~~~~~~~~.. . .. . . . . .. . . . . ....; .:-. i...by Martin Marietta Corporution ind in part by the Defense Advanced Research Projects Agency (DOD). DARPA Order iu. 3597, iu:4io,ed by the Air Force...Avionics Laboratory under Contract F3361531 .1(1539, and DARIPA Order -1 on, n tored by the Office of Naval Research , under Contract ;.MDA 903-81 -C0411

  9. Quantum AdaBoost algorithm via cluster state

    NASA Astrophysics Data System (ADS)

    Li, Yuan

    2017-03-01

    The principle and theory of quantum computation are investigated by researchers for many years, and further applied to improve the efficiency of classical machine learning algorithms. Based on physical mechanism, a quantum version of AdaBoost (Adaptive Boosting) training algorithm is proposed in this paper, of which purpose is to construct a strong classifier. In the proposed scheme with cluster state in quantum mechanism is to realize the weak learning algorithm, and then update the corresponding weight of examples. As a result, a final classifier can be obtained by combining efficiently weak hypothesis based on measuring cluster state to reweight the distribution of examples.

  10. Antiepileptogenic effects of glutathione against increased brain ADA in PTZ-induced epilepsy.

    PubMed

    Pence, Sadrettin; Erkutlu, Ibrahim; Kurtul, Naciye; Bosnak, Mehmet; Alptekin, Mehmet; Tan, Uner

    2009-01-01

    Adenosine has been shown to play a significant role as a modulator of neuronal activity in convulsive disorders, acting as an endogenous anticonvulsant agent. Any change in adenosine deaminase (ADA) levels will reflect to adenosine levels. In the present study, we have investigated the effect of glutathione on brain tissue ADA levels due to seizures induced by convulsive and subconvulsive dose of pentylenetetrazol (PTZ) in mice. ADA levels due to seizures induced by convulsive and subconvulsive pentylenetetrazol were measured using the Giusti method. ADA levels were higher in the experimental epilepsy groups than in the control and sham groups. ADA levels significantly decreased in the glutathione groups, which may have antiseizure effects. Decreased levels of ADA would be due to increased adenosine levels, protecting against oxidative stress.

  11. Ultrasonic methods for locating hold-up

    SciTech Connect

    Sinha, D.N.; Olinger, C.T.

    1995-09-01

    Hold-up remains one of the major contributing factors to unaccounted for materials and can be a costly problem in decontamination and decommissioning activities. Ultrasonic techniques are being developed to noninvasively monitor hold-up in process equipment where the inner surface of such equipment may be in contact with the hold-up material. These techniques may be useful in improving hold-up measurements as well as optimizing decontamination techniques.

  12. 12 CFR Appendix E to Part 360 - Hold File Structure

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... data file type and the date of the extract. The files will be encrypted using an FDIC-supplied.... Character (25). 7. HD_Hold_Amt Hold Amount Decimal (14,2). Dollar amount of the hold 8. HD_Hold_Reason Hold... Order Hold • FD = FDIC hold • OT = Other (do not include daily operational type holds) 9....

  13. Functional Analysis and Intervention for Breath Holding.

    ERIC Educational Resources Information Center

    Kern, Lee; And Others

    1995-01-01

    A functional analysis of breath-holding episodes in a 7-year-old girl with severe mental retardation and Cornelia-de-Lange syndrome indicated that breath holding served an operant function, primarily to gain access to attention. Use of extinction, scheduled attention, and a picture card communication system decreased breath holding. (Author/SW)

  14. 76 FR 36625 - Mutual Holding Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-22

    ... Office of Thrift Supervision Mutual Holding Company AGENCY: Office of Thrift Supervision (OTS), Treasury... collection. Title of Proposal: Mutual Holding Company. OMB Number: 1550-0072. Form Numbers: MHC-1 (OTS Form... whether the applicant meets the statutory and regulatory criteria to form a mutual holding company...

  15. 76 FR 20458 - Mutual Holding Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-12

    ... Office of Thrift Supervision Mutual Holding Company AGENCY: Office of Thrift Supervision (OTS), Treasury... collection. Title of Proposal: Mutual Holding Company. OMB Number: 1550-0072. Form Numbers: MHC-1 (OTS Form... whether the applicant meets the statutory and regulatory criteria to form a mutual holding company...

  16. Ada Adoption Handbook: A Program Manager’s Guide, Version 2.0

    DTIC Science & Technology

    1992-10-01

    crtical , and embedded applications. This handbook presents program managers with Information to make effective use of Ada. This handbook’ provides...for example, ground-based command and control systems or embedded avionics ) or specific programs. ’This handbook is one of two volumes of the Ada...using a single language, and software maintainability and reliability [193, 29, 107, 1911. An area where Ada’s impact has been positive Is in

  17. ADA3: a gene, identified by resistance to GAL4-VP16, with properties similar to and different from those of ADA2.

    PubMed Central

    Piña, B; Berger, S; Marcus, G A; Silverman, N; Agapite, J; Guarente, L

    1993-01-01

    We describe the isolation of a yeast gene, ADA3, mutations in which prevent the toxicity of GAL4-VP16 in vivo. Toxicity was previously proposed to be due to the trapping of general transcription factors required at RNA polymerase II promoters (S. L. Berger, B. Piña, N. Silverman, G. A. Marcus, J. Agapite, J. L. Regier, S. J. Triezenberg, and L. Guarente, Cell 70:251-265, 1992). trans activation by VP16 as well as the acidic activation domain of GCN4 is reduced in the mutant. Other activation domains, such as those of GAL4 and HAP4, are only slightly affected in the mutant. This spectrum is similar to that observed for mutants with lesions in ADA2, a gene proposed to encode a transcriptional adaptor. The ADA3 gene is not absolutely essential for cell growth, but gene disruption mutants grow slowly and are temperature sensitive. Strains doubly disrupted for ada2 and ada3 grow no more slowly than single mutants, providing further evidence that these genes function in the same pathway. Selection of initiation sites by the general transcriptional machinery in vitro is altered in the ada3 mutant, providing a clue that ADA3 could be a novel general transcription factor involved in the response to acidic activators. Images PMID:8413201

  18. Successful reconstitution of immunity in ADA-SCID by stem cell gene therapy following cessation of PEG-ADA and use of mild preconditioning.

    PubMed

    Gaspar, H Bobby; Bjorkegren, Emma; Parsley, Kate; Gilmour, Kimberly C; King, Doug; Sinclair, Joanna; Zhang, Fang; Giannakopoulos, Aris; Adams, Stuart; Fairbanks, Lynette D; Gaspar, Jane; Henderson, Lesley; Xu-Bayford, Jin Hua; Davies, E Graham; Veys, Paul A; Kinnon, Christine; Thrasher, Adrian J

    2006-10-01

    Gene therapy is a promising treatment option for monogenic diseases, but success has been seen in only a handful of studies thus far. We now document successful reconstitution of immune function in a child with the adenosine deaminase (ADA)-deficient form of severe combined immunodeficiency (SCID) following hematopoietic stem cell (HSC) gene therapy. An ADA-SCID child who showed a poor response to PEG-ADA enzyme replacement was enrolled into the clinical study. Following cessation of enzyme replacement therapy, autologous CD34(+) HSCs were transduced with an ADA-expressing gammaretroviral vector. Gene-modified cells were reinfused following one dose of preconditioning chemotherapy. Two years after the procedure, immunological and biochemical correction has been maintained with progressive increase in lymphocyte numbers, reinitiation of thymopoiesis, and systemic detoxification of ADA metabolites. Sustained vector marking with detection of polyclonal vector integration sites in multiple cell lineages and detection of ADA activity in red blood cells suggests transduction of early hematopoietic progenitors. No serious side effects were seen either as a result of the conditioning procedure or due to retroviral insertion. Gene therapy is an effective treatment option for the treatment of ADA-SCID.

  19. A 9-yr evaluation of carrier erythrocyte encapsulated adenosine deaminase (ADA) therapy in a patient with adult-type ADA deficiency.

    PubMed

    Bax, Bridget E; Bain, Murray D; Fairbanks, Lynette D; Webster, A David B; Ind, Philip W; Hershfield, Michael S; Chalmers, Ronald A

    2007-10-01

    Adenosine deaminase (ADA) deficiency is an inherited disorder which leads to elevated cellular levels of deoxyadenosine triphosphate (dATP) and systemic accumulation of its precursor, 2-deoxyadenosine. These metabolites impair lymphocyte function, and inactivate S-adenosylhomocysteine hydrolase (SAHH) respectively, leading to severe immunodeficiency. Enzyme replacement therapy with polyethylene glycol-conjugated ADA is available, but its efficacy is reduced by anti-ADA neutralising antibody formation. We report here carrier erythrocyte encapsulated native ADA therapy in an adult-type ADA deficient patient. Encapsulated enzyme is protected from antigenic responses and therapeutic activities are sustained. ADA-loaded autologous carrier erythrocytes were prepared using a hypo-osmotic dialysis procedure. Over a 9-yr period 225 treatment cycles were administered at 2-3 weekly intervals. Therapeutic efficacy was determined by monitoring immunological and metabolic parameters. After 9 yr of therapy, erythrocyte dATP concentration ranged between 24 and 44 micromol/L (diagnosis, 234) and SAHH activity between 1.69 and 2.29 nmol/h/mg haemoglobin (diagnosis, 0.34). Erythrocyte ADA activities were above the reference range of 40-100 nmol/h/mg haemoglobin (0 at diagnosis). Initial increases in absolute lymphocyte counts were not sustained; however, despite subnormal circulating CD20(+) cell numbers, serum immunoglobulin levels were normal. The patient tolerated the treatment well. The frequency of respiratory problems was reduced and the decline in the forced expiratory volume in 1 s and vital capacity reduced compared with the 4 yr preceding carrier erythrocyte therapy. Carrier erythrocyte-ADA therapy in an adult patient with ADA deficiency was shown to be metabolically and clinically effective.

  20. Rationale for the proposed standard for a generic package of elementary functions for Ada

    SciTech Connect

    Dritz, K.W.

    1989-03-01

    This paper supplements the ''Proposed Standard for a Generic Package of Elementary Functions for Ada,'' written by the ISO-IEC/JTC1/SC22/WG9 (Ada) Numerics Rapporteur Group for presentation to WG9. Based on recommendations made jointly by the ACM SIGAda Numerics Working Group and the Ada-Europe Numerics Working Group, the proposed elementary functions standard is the first of several anticipated collateral standards to address the interrelated issues of portability, efficiency, and robustness of numerical software written in Ada. Organized as a series of questions and answers, this supplement outlines the reasoning by which the proposed standard came to acquire certain features and exclude others. 20 refs.

  1. [Quasi-adaptive response to alkylating agents in Escherichia coli and Ada-protein functions].

    PubMed

    Vasil'eva, S V; Moshkovskaia, E Iu; Terekhov, A S; Mikoian, V D; Vanin, A F

    2008-01-01

    In 2005 we have described in exponentially growing E. coli cells a new fundamental genetic phenomenon,--quasi-adaptive response to alkylating compounds (quasi-Ada). Phenotypic expression of quasi-Ada is similar to the true Ada response. However, in contrast to the letter, it develops in the course of pretreatment of the cells by a sublethal dose of nonalkylating agent, an NO-containing dinitrosyl iron complex with glutathione (DNICglu). To reveal the mechanisms of quasi-adaptation and its association with the function of the Ada regulatory protein, here we used a unique property of dual gene expression regulation of aidB1 gene, a part of the Ada-regulon, namely its relative independence from Ada protein in anaerobic conditions. Based on the results of aidB1 gene expression analysis an EPR spectra of E. coli MV2176 cells (aidB1::lacZ) in aerobic and anaerobic conditions after the corresponding treatments, we conclude that the function and the spatial structure of meAda and [(Cys-)2Fe+(NO+)2]Ada are identical and thus the nitrosylated protein represents a regulator of the Ada regulon gene expression during quasi-adaptation development.

  2. Rationale for the proposed standard for a generic package of elementary functions for Ada

    SciTech Connect

    Dritz, K.W. )

    1989-10-01

    This paper supplements the Proposed Standard for a Generic Package of Elementary Functions for Ada,'' written by the ISO-IEC/JTC1/SC22/WG9 (Ada) Numerics Rapporteur Group. Based on recommendations made jointly by the ACM SIGAda Numerics Working Group and the Ada-Europe Numerics Working Group, the proposed elementary functions standard is the first of several anticipated collateral standards to address the interrelated issues of portability, efficiency, and robustness of numerical software written in Ada. Organized as a series of questions and answers, this supplement outlines the reasoning by which the proposed standard came to acquire certain features and exclude others. 22 refs.

  3. The implementation and use of Ada on distributed systems with high reliability requirements

    NASA Technical Reports Server (NTRS)

    Knight, J. C.

    1984-01-01

    The use and implementation of Ada in distributed environments in which reliability is the primary concern is investigated. Emphasis is placed on the possibility that a distributed system may be programmed entirely in ADA so that the individual tasks of the system are unconcerned with which processors they are executing on, and that failures may occur in the software or underlying hardware. The primary activities are: (1) Continued development and testing of our fault-tolerant Ada testbed; (2) consideration of desirable language changes to allow Ada to provide useful semantics for failure; (3) analysis of the inadequacies of existing software fault tolerance strategies.

  4. TRW’s Ada Process Model for Incremental Development of Large Software Systems

    DTIC Science & Technology

    1990-01-01

    TRW’s Ada Process Model has proven to be key to the Command Center Processing and Display System-Replacement (CCPDS-R) project’s success to data in...developing over 3000,000 lines of Ada source code executing in a distributed VAX VMS environment. The Ada Process Model is, in simplest terms, a...software progress metrics. This paper provides an overview of the techniques and benefits of the Ada Process Model and describes some of the experience and

  5. ART/Ada design project, phase 1. Task 2 report: Detailed design

    NASA Technical Reports Server (NTRS)

    Allen, Bradley P.

    1988-01-01

    Various issues are studied in the context of the design of an Ada based expert system building tool. Using an existing successful design as a starting point, the impact is analyzed of the Ada language and Ada development methodologies on that design, the Ada system is redesigned, and its performance is analyzed using both complexity-theoretic and empirical techniques. The algorithms specified in the overall design are refined, resolving and documenting any open design issues, identifying each system module, documenting the internal architecture and control logic, and describing the primary data structures involved in the module.

  6. Rationale for the proposed standard for a generic package of primitive functions for Ada

    SciTech Connect

    Dritz, K.W.

    1990-12-01

    This paper supplements the Proposed Standard for a Generic Package of Primitive Functions for Ada,'' written by the ISO- IEC/JTC1/SC22/WG9 (Ada) Numerics Rapporteur Group. Based on recommendations made jointly by the ACM SIGAda Numerics Working Group and the Ada-Europe Numerics Working Group, the proposed primitive functions standard is the second of several anticipated secondary standards to address the interrelated issues of portability, efficiency, and robustness of numerical software written in Ada. Its purpose, features, and developmental history are outlined in this commentary. 16 refs.

  7. Efficient Ada multitasking on a RISC register window architecture

    NASA Technical Reports Server (NTRS)

    Kearns, J. P.; Quammen, D.

    1987-01-01

    This work addresses the problem of reducing context switch overhead on a processor which supports a large register file - a register file much like that which is part of the Berkeley RISC processors and several other emerging architectures (which are not necessarily reduced instruction set machines in the purest sense). Such a reduction in overhead is particularly desirable in a real-time embedded application, in which task-to-task context switch overhead may result in failure to meet crucial deadlines. A storage management technique by which a context switch may be implemented as cheaply as a procedure call is presented. The essence of this technique is the avoidance of the save/restore of registers on the context switch. This is achieved through analysis of the static source text of an Ada tasking program. Information gained during that analysis directs the optimized storage management strategy for that program at run time. A formal verification of the technique in terms of an operational control model and an evaluation of the technique's performance via simulations driven by synthetic Ada program traces are presented.

  8. Space station Ada runtime support for nested atomic transactions

    NASA Technical Reports Server (NTRS)

    Monteiro, Edward J.

    1986-01-01

    The Space Station Data Management System (DMS), associated computing subsystems, and applications have varying degrees of reliability associated with their operation. A model has been developed (McKay '86) which allows the DMS runtime environment to appear as an Ada virtual machine to applications executing within it. This model is modular, flexible, and dynamically configurable to allow for evolution and growth over time. Support for Fault-tolerant computing is included within this model. The basic primitive involved in this support is based on atomic actions (Grey '78). An atomic action possesses two fundamental properties: (1) it is indivisible with respect to concurrent actions, and (2) it is indivisible with respect to failure. A transaction is a collection of atomic actions which collectively appear to be one action. Transactions may be nested, providing even more powerful support for reliability. A proposed approach is described for providing support for nested atomic transactions within the Ada runtime model developed for the Space Station environment. The level of support is modular, flexible and dynamically configurable just like the overall runtime support environment.

  9. 78 FR 23162 - Supervision and Regulation Assessments for Bank Holding Companies and Savings and Loan Holding...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-18

    ... company that, on December 31 of the assessment period, is a top-tier bank holding company, other than a...-tier savings and loan holding company, other than a foreign savings and loan holding company, as... would be the top-tier, regulated holding company. If a U.S.-domiciled company does not report...

  10. Ada (Trade Name) Compiler Validation Summary Report. ALSYS AlsyCOMP 002, Version 1.0, HP 9000/220 & HP 9000/320.

    DTIC Science & Technology

    1985-11-02

    p C53񓆸. ADA P C55S67A-AS. DEP P 05901S-AS .ADA P C53U5A- ABADA P C55007E-.AS .DEP p C59002A-AS .ADA P C53005B-AS. ADA P C55BOSA-S . ADA P C590028...AS-.ADA P C53"GA-A . ADA P C55B69A-AS .ADA P C5gOO2C-S .ADA P C53ඍ-AB .ADA P C5581 5A-B .ADA P 055A83A-A . ADA P C53śA- ABADA P C55B1 SA-AS .DEP N/A... ABADA P B71001U-A.ADA P 874265A-8.ADA P A73ft1J-AD.ADA p 671801V-AD.ADA P 9742658-D.ADA P A74606A-AB .ADA p 971 661W-AD. ADA P B74207A- .ADA W A74105

  11. Do published ADA studies support the ADA-EASD position statement for the management of hyperglycaemia in type 2 diabetics?

    PubMed

    Rimareix, Frédérique; Bauduceau, Bernard

    2013-07-01

    The American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) published a position statement in 2012 on the management of hyperglycaemia in patients with type 2 diabetes. The Société Francophone du Diabète (SFD) adopted it while awaiting future French recommendations. This new care approach individualises the therapeutic choices and objectives for each patient based on their characteristics, through emphasis on the need for mutual cooperation with the patient in decision-making. Glycaemic management should naturally be considered in the context of overall cardiovascular risk reduction, which should remain the primary objective of treatment. The cornerstone of this treatment is based on lifestyle modifications, with the addition of metformin monotherapy if the desired glycaemic control is not attained. There are multiple second- and third-line treatment possibilities, and insulin therapy is an option that can be considered early in the bitherapy stage. On the whole, large published studies at the ADA conference in Philadelphia in June 2012, which are the subject of this article, support this patient-centred position statement.

  12. Numerical Simulation and Chaotic Analysis of an Aluminum Holding Furnace

    NASA Astrophysics Data System (ADS)

    Wang, Ji-min; Zhou, Yuan-yuan; Lan, Shen; Chen, Tao; Li, Jie; Yan, Hong-jie; Zhou, Jie-min; Tian, Rui-jiao; Tu, Yan-wu; Li, Wen-ke

    2014-12-01

    To achieve high heat efficiency, low pollutant emission and homogeneous melt temperature during thermal process of secondary aluminum, taking into account the features of aluminum alloying process, a CFD process model was developed and integrated with heat load and aluminum temperature control model. This paper presented numerical simulation of aluminum holding furnaces using the customized code based on FLUENT packages. Thermal behaviors of aluminum holding furnaces were investigated by probing into main physical fields such as flue gas temperature, velocity, and concentration, and combustion instability of aluminum holding process was represented by chaos theory. The results show that aluminum temperature uniform coefficient firstly decreases during heating phase, then increases and reduces alternately during holding phase, lastly rises during standing phase. Correlation dimension drops with fuel velocity. Maximal Lyapunov exponent reaches to a maximum when air-fuel ratio is close to 1. It would be a clear comprehension about each phase of aluminum holding furnaces to find new technology, retrofit furnace design, and optimize parameters combination.

  13. Hyperbilirubinemia and rapid fatal hepatic failure in severe combined immunodeficiency caused by adenosine deaminase deficiency (ADA-SCID).

    PubMed

    Kühl, J S; Schwarz, K; Münch, A; Schmugge, M; Pekrun, A; Meisel, C; Wahn, V; Ebell, W; von Bernuth, H

    2011-03-01

    Adenosin deaminase (ADA) deficiency is the cause for Severe Combined Immunodeficiency (SCID) in about 15% of patients with SCID, often presenting as T (-)B (-)NK (-)SCID. Treatment options for ADA-SCID are enzyme replacement, bone marrow transplantation or gene therapy. We here describe the first patient with ADA-SCID and fatal hepatic failure despite bone marrow transplantation from a 10/10 HLA identical related donor. As patients with ADA-SCID may be at yet underestimated increased risk for rapid hepatic failure we speculate whether hepatitis in ADA-SCID should lead to the immediate treatment with enzyme replacement by pegylated ADA.

  14. Carrier frequency of a nonsense mutation in the adenosine deaminase (ADA) gene implies a high incidence of ADA-deficient severe combined immunodeficiency (SCID) in Somalia and a single, common haplotype indicates common ancestry.

    PubMed

    Sanchez, Juan J; Monaghan, Gemma; Børsting, Claus; Norbury, Gail; Morling, Niels; Gaspar, H Bobby

    2007-05-01

    Inherited adenosine deaminase (ADA) deficiency is a rare metabolic disorder that causes immunodeficiency, varying from severe combined immunodeficiency (SCID) in the majority of cases to a less severe form in a small minority of patients. Five patients of Somali origin from four unrelated families, with severe ADA-SCID, were registered in the Greater London area. Patients and their parents were investigated for the nonsense mutation Q3X (ADA c7C>T), two missense mutations K80R (ADA c239A>G) and R142Q (ADA c425G>A), and a TAAA repeat located at the 3' end of an Alu element (AluVpA) positioned 1.1 kb upstream of the ADA transcription start site. All patients were homozygous for the haplotype ADA-7T/ADA-239G/ADA-425G/AluVpA7. Among 207 Somali immigrants to Denmark, the frequency of ADA c7C>T and the maximum likelihood estimate of the frequency of the haplotype ADA-7T/ADA-239G/ADA-425G/AluVpA7 were both 0.012 (carrier frequency 2.4%). Based on the analysis of AluVpA alleles, the ADA c7C/T mutation was estimated to be approximately 7,100 years old. Approximately 1 out of 5 - 10000 Somali children will be born with ADA deficiency due to an ADA c7C/T mutation, although within certain clans the frequency may be significantly higher. ADA-SCID may be a frequent immunodeficiency disorder in Somalia, but will be underdiagnosed due to the prevailing socioeconomic and nutritional deprivation.

  15. Towards a rAAV-based gene therapy for ADA-SCID: from ADA deficiency to current and future treatment strategies.

    PubMed

    Silver, Jared N; Flotte, Terence R

    2008-07-01

    Adenosine deaminase deficiency fosters a rare, devastating pediatric immune deficiency with concomitant opportunistic infections, metabolic anomalies and multiple organ system pathology. The standard of care for adenosine deaminase deficient severe combined immune deficiency (ADA-SCID) includes enzyme replacement therapy or bone marrow transplantation. Gene therapies for ADA-SCID over nearly two decades have exclusively involved retroviral vectors targeted to lymphocytes and hematopoetic progenitors. These groundbreaking gene therapies represent a revolution in clinical medicine, but come with several challenges, including the risk of insertional mutagenesis. An alternative gene therapy for ADA-SCID may utilize recombinant adeno-associated virus vectors in vivo, with numerous target tissues, to foster ectopic expression and secretion of adenosine deaminase. This review endeavors to describe ADA-SCID, the traditional treatments, previous retroviral gene therapies, and primarily, alternative recombinant adeno-associated virus-based strategies to remedy this potentially fatal genetic disease.

  16. GRODY - GAMMA RAY OBSERVATORY DYNAMICS SIMULATOR IN ADA

    NASA Technical Reports Server (NTRS)

    Stark, M.

    1994-01-01

    Analysts use a dynamics simulator to test the attitude control system algorithms used by a satellite. The simulator must simulate the hardware, dynamics, and environment of the particular spacecraft and provide user services which enable the analyst to conduct experiments. Researchers at Goddard's Flight Dynamics Division developed GRODY alongside GROSS (GSC-13147), a FORTRAN simulator which performs the same functions, in a case study to assess the feasibility and effectiveness of the Ada programming language for flight dynamics software development. They used popular object-oriented design techniques to link the simulator's design with its function. GRODY is designed for analysts familiar with spacecraft attitude analysis. The program supports maneuver planning as well as analytical testing and evaluation of the attitude determination and control system used on board the Gamma Ray Observatory (GRO) satellite. GRODY simulates the GRO on-board computer and Control Processor Electronics. The analyst/user sets up and controls the simulation. GRODY allows the analyst to check and update parameter values and ground commands, obtain simulation status displays, interrupt the simulation, analyze previous runs, and obtain printed output of simulation runs. The video terminal screen display allows visibility of command sequences, full-screen display and modification of parameters using input fields, and verification of all input data. Data input available for modification includes alignment and performance parameters for all attitude hardware, simulation control parameters which determine simulation scheduling and simulator output, initial conditions, and on-board computer commands. GRODY generates eight types of output: simulation results data set, analysis report, parameter report, simulation report, status display, plots, diagnostic output (which helps the user trace any problems that have occurred during a simulation), and a permanent log of all runs and errors. The

  17. Ada Compiler Validation Summary Report: Siemens AG Siemens BS2000 Ada Compiler, Version 1.0 Siemens 7.57OP.

    DTIC Science & Technology

    1987-02-26

    STD-]815A, FEB 1983. 2. Ada Validation Organization: Policies and Procedures, MITRE Corporation , JUN 1982, PB 83-110601. 3. Ada Compiler Validation...expression’s suhtyne is comnatible with the target’s sub- type. In assigning two-dimensional array types, the expression does not appear to be evaluated...owner’s corporate name. Siemens Aktiengesellschaft -- 7 ,Spa . ’. ’.,,,, .- ’.% ’ " ’ ,-.-,ŗ’/ ,’,’ ’ ’,,- ’ % 3

  18. Fair Play for Disabled Persons: Our Responsibilities under the New ADA.

    ERIC Educational Resources Information Center

    Simpkins, Karen L.; Kaplan, Rochelle K.

    1991-01-01

    Examines legal requirements of employment and public accommodation provisions of Americans with Disabilities Act of 1990 (ADA) as they apply to career services and recruitment operations. Defines Title I, employment provisions, and Title III, provisions related to public accommodations and commercial facilities, of ADA. Discusses how recruiters…

  19. School Issues Under [Section] 504 and the ADA: The Latest and Greatest.

    ERIC Educational Resources Information Center

    Aleman, Steven R.

    This paper highlights recent guidance and rulings from the Office of Civil Rights (OCR) of interest to administrators, advocates, and attorneys. It is a companion piece to Student Issues on SectionNB504/ADA: The Latest and Greatest. Compliance with SectionNB504 and the Americans with Disabilities Act (ADA) continues to involve debate and dialog on…

  20. An Assessment of Ada’s Suitability in General Purpose Programming Applications.

    DTIC Science & Technology

    1985-09-01

    selected to honor the mathematician Lady Augusta Ada Byron (1815-1852), Countess of Lovelace. The Countess worked with Charles Babbage on his difference...stray from our research objectives. We would also like to thank Dr. Charles Richard for the assistance he gave us while learning the Ada language

  1. Application of Ada higher-order language to guidance and control. Lecture series

    SciTech Connect

    Not Available

    1986-05-01

    The Department of Defense stated that Ada shall become the single, common computer-programming language for Defense mission-critical applications beginning in 1984. The proposal to make Ada a NATO standard High Order Language (HOL) as well, prompted the GCP to provide a Lecture Series embracing the basic structure, theories, and principles embodied in this HOL. The need to reduce escalating software life-cycle costs is the raison d'etre for Ada. Early experience with the language suggests that the promise of increased software productivity can be fulfilled. However, many problems remain; the need for validated and efficient compilers targeted for computers suitable to the guidance and control application, and software development environments built around Ada, are two among the foremost. This Lecture Series addresses both the promise and the problems. Following an introduction to Ada, the structure and features of the language are described. Two special features of Ada, parallel processing and software reusability, are discussed in detail. Compiler development and validation, and the use of Ada in programming environments are described. Finally, the use of Ada in a real-world pilot project is described.

  2. Voices of Freedom: America Speaks Out on the ADA. A Report to the President and Congress.

    ERIC Educational Resources Information Center

    National Council on Disability, Washington, DC.

    This report examines the implementation of the Americans with Disabilities Act (ADA) during the 5 years since its passage in 1990. An introductory chapter considers the overall importance of the Act; the continuing interest of the National Council on Disability (NCD) in the ADA; and the visits of NCD representatives to each of the 50 states, the…

  3. The G22A Polymorphism of the ADA Gene and Susceptibility to Autism Spectrum Disorders

    ERIC Educational Resources Information Center

    Hettinger, Joe A.; Liu, Xudong; Holden, Jeanette Jeltje Anne

    2008-01-01

    Inborn errors of purine metabolism have been implicated as a cause for some cases of autism. This hypothesis is supported by the finding of decreased adenosine deaminase (ADA) activity in the sera of some children with autism and reports of an association of the A allele of the ADA G22A (Asp8Asn) polymorphism in individuals with autism of…

  4. The "Ada" Verb of Being in Bahasa Malaysia. Colorado Research in Linguistics, No. 4.

    ERIC Educational Resources Information Center

    Mader, Robin

    This paper examines the various syntactic and semantic functions of the "ada" verb of "being" in Malay. The claim is made that there is an abstract uppermost "ada" in the underlying structure of Malay sentences that asserts or denies the truth of the surface main clause. A further claim is made that the…

  5. NRPA Law Review. Combat Karate Class Illustrates ADA "Direct Threat" Exception.

    ERIC Educational Resources Information Center

    Kozlowski, James C.

    2000-01-01

    Describes the Americans with Disabilities Act (ADA), which prohibits discrimination against people with disabilities, highlighting a lawsuit involving a boy with AIDS who was barred from a traditional combat-oriented martial arts school. Courts ruled that his exclusion did not violate the ADA because he posed significant health and safety risks to…

  6. 76 FR 31892 - Recordkeeping and Reporting Requirements Under Title VII, the ADA, and GINA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-02

    ... COMMISSION 29 CFR Part 1602 RIN 3046-AA89 Recordkeeping and Reporting Requirements Under Title VII, the ADA... regulations is therefore minimal. An employer subject to the existing requirement in 29 CFR part 1602... to the recordkeeping requirement in Part 1602. The currently approved Title VII and ADA...

  7. Holding Steadfast to the Humanities

    ERIC Educational Resources Information Center

    Nace, Felecia

    2012-01-01

    Much of the focus in education has shifted toward science, technology, engineering, and mathematics (STEM). The growing importance of those subjects is based primarily on the projection that some countries will fall short of homegrown young adults who can meet the demands of the future job market unless educators act judiciously. But in the quest…

  8. Large distributed control system using Ada in fusion research

    SciTech Connect

    Van Arsdall, P J; Woodruff, J P

    1998-08-11

    Construction of the National Ignition Facility laser at Lawrence Livermore National Laboratory features a distributed control system that uses object-oriented software engineering techniques. Control of 60,000 devices is effected using a network of some 500 computers. The software is being written in Ada and communicates through CORBA. Software controls are implemented in two layers: individual device controllers and a supervisory layer. The software architecture provides services in the form of frameworks that address issues common to event-driven control systems. Those services are allocated to levels that strictly prescribe their interdependency so the levels are separately reusable. The project has completed its final design review. The delivery of the first increment takes place in October 1998. Keywords Distributed control system, object-oriented development, CORBA, application frameworks, levels of abstraction

  9. Programming in a proposed 9X distributed Ada

    NASA Technical Reports Server (NTRS)

    Waldrop, Raymond S.; Volz, Richard A.; Goldsack, Stephen J.

    1990-01-01

    The proposed Ada 9X constructs for distribution was studied. The goal was to select suitable test cases to help in the evaluation of the proposed constructs. The examples were to be considered according to the following requirements: real time operation; fault tolerance at several different levels; demonstration of both distributed and massively parallel operation; reflection of realistic NASA programs; illustration of the issues of configuration, compilation, linking, and loading; indications of the consequences of using the proposed revisions for large scale programs; and coverage of the spectrum of communication patterns such as predictable, bursty, small and large messages. The first month was spent identifying possible examples and judging their suitability for the project.

  10. Rehosting and retargeting an Ada compiler: A design study

    NASA Technical Reports Server (NTRS)

    Robinson, Ray

    1986-01-01

    The goal of this study was to develop a plan for rehosting and retargeting the Air Force Armaments Lab. Ada cross compiler. This compiler was validated in Sept. 1985 using ACVC 1.6, is written in Pascal, is hosted on a CDC Cyber 170, and is targeted to an embedded Zilog Z8002. The study was performed to determine the feasibility, cost, time, and tasks required to retarget the compiler to a DEC VAX 11/78x and rehost it to an embedded U.S. Navy AN/UYK-44 computer. Major tasks identified were rehosting the compiler front end, rewriting the back end (code generator), translating the run time environment from Z8002 assembly language to AN/UYK-44 assembly language, and developing a library manager.

  11. Storage management in Ada. Three reports. Volume 1: Storage management in Ada as a risk to the development of reliable software. Volume 2: Relevant aspects of language. Volume 3: Requirements of the language versus manifestations of current implementations

    NASA Technical Reports Server (NTRS)

    Auty, David

    1988-01-01

    The risk to the development of program reliability is derived from the use of a new language and from the potential use of new storage management techniques. With Ada and associated support software, there is a lack of established guidelines and procedures, drawn from experience and common usage, which assume reliable behavior. The risk is identified and clarified. In order to provide a framework for future consideration of dynamic storage management on Ada, a description of the relevant aspects of the language is presented in two sections: Program data sources, and declaration and allocation in Ada. Storage-management characteristics of the Ada language and storage-management characteristics of Ada implementations are differentiated. Terms that are used are defined in a narrow and precise sense. The storage-management implications of the Ada language are described. The storage-management options available to the Ada implementor and the implications of the implementor's choice for the Ada programmer are also described.

  12. The implementation and use of Ada on distributed systems with high reliability requirements

    NASA Technical Reports Server (NTRS)

    Knight, J. C.

    1988-01-01

    The use and implementation of Ada were investigated in distributed environments in which reliability is the primary concern. In particular, the focus was on the possibility that a distributed system may be programmed entirely in Ada so that the individual tasks of the system are unconcerned with which processors are being executed, and that failures may occur in the software and underlying hardware. A secondary interest is in the performance of Ada systems and how that performance can be gauged reliably. Primary activities included: analysis of the original approach to recovery in distributed Ada programs using the Advanced Transport Operating System (ATOPS) example; review and assessment of the original approach which was found to be capable of improvement; development of a refined approach to recovery that was applied to the ATOPS example; and design and development of a performance assessment scheme for Ada programs based on a flexible user-driven benchmarking system.

  13. The implementation and use of Ada on distributed systems with high reliability requirements

    NASA Technical Reports Server (NTRS)

    Knight, J. C.; Gregory, S. T.; Urquhart, J. I. A.

    1985-01-01

    The use and implementation of Ada in distributed environments in which reliability is the primary concern were investigated. In particular, the concept that a distributed system may be programmed entirely in Ada so that the individual tasks of the system are unconcerned with which processors they are executing on, and that failures may occur in the software or underlying hardware was examined. Progress is discussed for the following areas: continued development and testing of the fault-tolerant Ada testbed; development of suggested changes to Ada so that it might more easily cope with the failure of interest; and design of new approaches to fault-tolerant software in real-time systems, and integration of these ideas into Ada.

  14. The implementation and use of Ada on distributed systems with reliability requirements

    NASA Technical Reports Server (NTRS)

    Reynolds, P. F.; Knight, J. C.; Urquhart, J. I. A.

    1983-01-01

    The issues involved in the use of the programming language Ada on distributed systems are discussed. The effects of Ada programs on hardware failures such as loss of a processor are emphasized. It is shown that many Ada language elements are not well suited to this environment. Processor failure can easily lead to difficulties on those processors which remain. As an example, the calling task in a rendezvous may be suspended forever if the processor executing the serving task fails. A mechanism for detecting failure is proposed and changes to the Ada run time support system are suggested which avoid most of the difficulties. Ada program structures are defined which allow programs to reconfigure and continue to provide service following processor failure.

  15. AdaRTE: adaptable dialogue architecture and runtime engine. A new architecture for health-care dialogue systems.

    PubMed

    Rojas-Barahona, L M; Giorgino, T

    2007-01-01

    Spoken dialogue systems have been increasingly employed to provide ubiquitous automated access via telephone to information and services for the non-Internet-connected public. In the health care context, dialogue systems have been successfully applied. Nevertheless, speech-based technology is not easy to implement because it requires a considerable development investment. The advent of VoiceXML for voice applications contributed to reduce the proliferation of incompatible dialogue interpreters, but introduced new complexity. As a response to these issues, we designed an architecture for dialogue representation and interpretation, AdaRTE, which allows developers to layout dialogue interactions through a high level formalism that offers both declarative and procedural features. AdaRTE aim is to provide a ground for deploying complex and adaptable dialogues whilst allows the experimentation and incremental adoption of innovative speech technologies. It provides the dynamic behavior of Augmented Transition Networks and enables the generation of different backends formats such as VoiceXML. It is especially targeted to the health care context, where a framework for easy dialogue deployment could reduce the barrier for a more widespread adoption of dialogue systems.

  16. Adaptable dialog architecture and runtime engine (AdaRTE): a framework for rapid prototyping of health dialog systems.

    PubMed

    Rojas-Barahona, L M; Giorgino, T

    2009-04-01

    Spoken dialog systems have been increasingly employed to provide ubiquitous access via telephone to information and services for the non-Internet-connected public. They have been successfully applied in the health care context; however, speech technology requires a considerable development investment. The advent of VoiceXML reduced the proliferation of incompatible dialog formalisms, at the expense of adding even more complexity. This paper introduces a novel architecture for dialogue representation and interpretation, AdaRTE, which allows developers to lay out dialog interactions through a high-level formalism, offering both declarative and procedural features. AdaRTE's aim is to provide a ground for deploying complex and adaptable dialogs whilst allowing experimentation and incremental adoption of innovative speech technologies. It enhances augmented transition networks with dynamic behavior, and drives multiple back-end realizers, including VoiceXML. It has been especially targeted to the health care context, because of the great scale and the need for reducing the barrier to a widespread adoption of dialog systems.

  17. Ada Compiler Validation Summary Report. Certificate Number: 880715S1. 09153. InterACT Corporation, InterACT Ada 1750A Compiler System, Release 3.0 VAX 11/785 Host, Fairchild F9450/1750A Target

    DTIC Science & Technology

    1988-07-15

    Programming language, Ada Compiler Validation Summary Report, Ada Compiler Validation Capability, ACVC, Validation Testing, Ada Validation Office, AVO ...the Ada Validation Organization ( AVO ). On-site testing was completed on 16 July 1988 at InterACT Corporation, New York, New York. 1.2 USE OF TIS...VAL1ITION SUMZMY REPOFG Consistent with the national laws of the originating country, the AVO may make full and free public disclosure of this report. In

  18. Ada Compiler Validation Summary Report: Certificate Number: 890919W1. 10168, R.R. Software, Inc., Janus/ADA, Version 2.1.3, Northgate 386 under SCO UNIX

    DTIC Science & Technology

    1989-09-19

    Capability, ACVC, Validation Testing, Ada Validation Office, AVO , Ada Validation Facility, AVF, ANSI/PIL-STD- l8lSA, Ada Joint Program Office, A3PO 20...the Ada Validation Organization ( AVO ). On-site testing was completed 19 September 1989 at Madison WI. 1.2 USE OF THIS VALIDATION SUMMARY REPORT...Consistent with the national laws of the originating country, the AVO may make full and free public disclosure of this report. In the United States, this is

  19. Research, development, training, and education using the Ada programming language. Final report, 1 September 1987-31 May 1989

    SciTech Connect

    Harrison, G.C.

    1989-07-16

    The primary goal of this activity was to conduct research in the application and development of Ada, and in broader terms the objectives were as follows: (1) To develop numerical algorithms for parallel processing using the Ada language; (2) To develop new methodologies in reusing Ada software; (3) To solve select problems in applied mathematics using MACSYMA and Ada; (4) Simulate the interactions of nodes in a network using Ada; (5) To increase the cadre of educations available to provide Ada training by conducting Ada workshops for Norfolk State University faculty and staff; (6) To develop a series of in-class and individualized modules addressing Ada programming using computer-assisted instruction; and (7) To disseminate research and computer-aided instruction modules to other minority institutions through computer networking, workshops, and lecture series.

  20. Subunits of ADA-two-A-containing (ATAC) or Spt-Ada-Gcn5-acetyltrasferase (SAGA) Coactivator Complexes Enhance the Acetyltransferase Activity of GCN5.

    PubMed

    Riss, Anne; Scheer, Elisabeth; Joint, Mathilde; Trowitzsch, Simon; Berger, Imre; Tora, László

    2015-11-27

    Histone acetyl transferases (HATs) play a crucial role in eukaryotes by regulating chromatin architecture and locus specific transcription. GCN5 (KAT2A) is a member of the GNAT (Gcn5-related N-acetyltransferase) family of HATs. In metazoans this enzyme is found in two functionally distinct coactivator complexes, SAGA (Spt Ada Gcn5 acetyltransferase) and ATAC (Ada Two A-containing). These two multiprotein complexes comprise complex-specific and shared subunits, which are organized in functional modules. The HAT module of ATAC is composed of GCN5, ADA2a, ADA3, and SGF29, whereas in the SAGA HAT module ADA2b is present instead of ADA2a. To better understand how the activity of human (h) hGCN5 is regulated in the two related, but different, HAT complexes we carried out in vitro HAT assays. We compared the activity of hGCN5 alone with its activity when it was part of purified recombinant hATAC or hSAGA HAT modules or endogenous hATAC or hSAGA complexes using histone tail peptides and full-length histones as substrates. We demonstrated that the subunit environment of the HAT complexes into which GCN5 incorporates determines the enhancement of GCN5 activity. On histone peptides we show that all the tested GCN5-containing complexes acetylate mainly histone H3K14. Our results suggest a stronger influence of ADA2b as compared with ADA2a on the activity of GCN5. However, the lysine acetylation specificity of GCN5 on histone tails or full-length histones was not changed when incorporated in the HAT modules of ATAC or SAGA complexes. Our results thus demonstrate that the catalytic activity of GCN5 is stimulated by subunits of the ADA2a- or ADA2b-containing HAT modules and is further increased by incorporation of the distinct HAT modules in the ATAC or SAGA holo-complexes.

  1. Fusion of optimized indicators from Advanced Driver Assistance Systems (ADAS) for driver drowsiness detection.

    PubMed

    Daza, Iván García; Bergasa, Luis Miguel; Bronte, Sebastián; Yebes, Jose Javier; Almazán, Javier; Arroyo, Roberto

    2014-01-09

    This paper presents a non-intrusive approach for monitoring driver drowsiness using the fusion of several optimized indicators based on driver physical and driving performance measures, obtained from ADAS (Advanced Driver Assistant Systems) in simulated conditions. The paper is focused on real-time drowsiness detection technology rather than on long-term sleep/awake regulation prediction technology. We have developed our own vision system in order to obtain robust and optimized driver indicators able to be used in simulators and future real environments. These indicators are principally based on driver physical and driving performance skills. The fusion of several indicators, proposed in the literature, is evaluated using a neural network and a stochastic optimization method to obtain the best combination. We propose a new method for ground-truth generation based on a supervised Karolinska Sleepiness Scale (KSS). An extensive evaluation of indicators, derived from trials over a third generation simulator with several test subjects during different driving sessions, was performed. The main conclusions about the performance of single indicators and the best combinations of them are included, as well as the future works derived from this study.

  2. Catalog of Resources for Education in Ada (Trade Name) and Software Engineering (CREASE). Version 4.0.

    DTIC Science & Technology

    1986-05-01

    type of organization offering the course is a company. Name and Address of offeror: Infotrans 27 Poter Pond Lexington. MA 02173 Offeror s B ckgound: The...Ada language (1982 Department of Defense Standard). Introduction to Ada CREASE Version 4.0 231 Invitation to Ada & Ada Reference Manual Author(s) Harry ...s) Harry Katzan Jr., Katzan International Published by: Petrocelli Books, Inc. Publication date: 1984 ISBN: 089433-239-2 Ubrary of Congress: 83-26968

  3. The ada operon of Mycobacterium tuberculosis encodes two DNA methyltransferases for inducible repair of DNA alkylation damage.

    PubMed

    Yang, Mingyi; Aamodt, Randi M; Dalhus, Bjørn; Balasingham, Seetha; Helle, Ina; Andersen, Pernille; Tønjum, Tone; Alseth, Ingrun; Rognes, Torbjørn; Bjørås, Magnar

    2011-06-10

    The ada operon of Mycobacterium tuberculosis, which encodes a composite protein of AdaA and AlkA and a separate AdaB/Ogt protein, was characterized. M. tuberculosis treated with N-methyl-N'-nitro-N-nitrosoguanidine induced transcription of the adaA-alkA and adaB genes, suggesting that M. tuberculosis mount an inducible response to methylating agents. Survival assays of the methyltransferase defective Escherichia coli mutant KT233 (ada ogt), showed that expression of the adaB gene rescued the alkylation sensitivity. Further, adaB but not adaA-alkA complemented the hypermutator phenotype of KT233. Purified AdaA-AlkA and AdaB possessed methyltransferase activity. These data suggested that AdaB counteract the cytotoxic and mutagenic effect of O(6)-methylguanine, while AdaA-AlkA most likely transfers methyl groups from innocuous methylphosphotriesters. AdaA-AlkA did not possess alkylbase DNA glycosylase activity nor rescue the alkylation sensitivity of the E. coli mutant BK2118 (tag alkA). We propose that AdaA-AlkA is a positive regulator of the adaptive response in M. tuberculosis. It thus appears that the ada operon of M. tuberculosis suppresses the mutagenic effect of alkylation but not the cytotoxic effect of lesions such as 3-methylpurines. Collectively, these data indicate that M. tuberculosis hypermutator strains with defective adaptive response genes might sustain robustness to cytotoxic alkylation DNA damage and confer a selective advantage contributing to host adaptation.

  4. Structural System Identification Technology Verification

    DTIC Science & Technology

    1981-11-01

    USAAVRADCOM-TR-81-D-28Q V󈧄 ADA1091 81 LEI STRUCTURAL SYSTEM IDENTIFICATION TECHNOLOGY VERIFICATION \\ N. Giansante, A. Berman, W. o. Flannelly, E...release; distribution unlimited. Prepared for APPLIED TECHNOLOGY LABORATORY U. S. ARMY RESEARCH AND TECHNOLOGY LABORATORIES (AVRADCOM) S Fort Eustis...Va. 23604 4-J" APPLI ED TECHNOLOGY LABORATORY POSITION STATEMENT The Applied Technology Laboratory has been involved in the development of the Struc

  5. Holding fixture for metallographic mount polishing

    DOEpatents

    Barth, C.H.; Cramer, C.E.

    1997-12-30

    A fixture is described for holding mounted specimens for polishing, having an arm; a body attached to one end of the arm, the body having at least one flange having an opening to accommodate a mounted specimen; and a means applying pressure against the outer surface of the mounted specimen to hold the specimen in contact with the polishing surface. 3 figs.

  6. Holding fixture for metallographic mount polishing

    DOEpatents

    Barth, Clyde H.; Cramer, Charles E.

    1997-01-01

    A fixture for holding mounted specimens for polishing, having an arm; a body attached to one end of the arm, the body having at least one flange having an opening to accommodate a mounted specimen; and a means applying pressure against the outer surface of the mounted specimen to hold the specimen in contact with the polishing surface.

  7. School Budget Hold'em Facilitator's Guide

    ERIC Educational Resources Information Center

    Education Resource Strategies, 2012

    2012-01-01

    "School Budget Hold'em" is a game designed to help school districts rethink their budgeting process. It evolved out of Education Resource Strategies' (ERS) experience working with large urban districts around the country. "School Budget Hold'em" offers a completely new approach--one that can turn the budgeting process into a long-term visioning…

  8. Holdings as a Measure of Journal Value.

    ERIC Educational Resources Information Center

    Wallace, Danny P.; Boyce, Bert R.

    1989-01-01

    Describes a study that compared holdings figures from the OCLC database to productivity measures from the "Journal Citation Reports" section of "Science Citation Index" and publisher circulation figures to determine whether there is a systematic relationship between easily gathered holdings and circulation figures and less…

  9. 12 CFR 34.82 - Holding period.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY REAL ESTATE LENDING AND APPRAISALS Other Real Estate Owned § 34.82 Holding period. (a) Holding period for OREO. A national bank shall dispose of... estate acquired for future bank expansion. (c) Effect of statutory redemption period. For DPC real...

  10. Error-Compensated Integrate and Hold

    NASA Technical Reports Server (NTRS)

    Matlin, M.

    1984-01-01

    Differencing circuit cancels error caused by switching transistors capacitance. In integrate and hold circuit using JFET switch, gate-to-source capacitance causes error in output voltage. Differential connection cancels out error. Applications in systems where very low voltages sampled or many integrate-and -hold cycles before circuit is reset.

  11. On-line replacement of program modules using AdaPT

    NASA Technical Reports Server (NTRS)

    Waldrop, Raymond S.; Volz, Richard A.; Smith, Gary W.; Holzbacher-Valero, A. A.; Goldsack, Stephen J.

    1992-01-01

    One purpose of our research is the investigation of the effectiveness and expressiveness of AdaPT(1), a set of language extensions to Ada 83, for distributed systems. As a part of that effort, we are now investigating the subject of replacing, e.g., upgrading, software modules while the software system remains in operation. The AdaPT language extension provide a good basis for this investigation for several reasons: (1) they include the concept of specific, self-contained program modules which can be manipulated; (2) support for program configuration is included in the language; and (3) although the discussion will be in terms of the AdaPT language, the AdaPT to Ada 83 conversion methodology being developed as another part of this project will provide a basis for the application of our findings to Ada 83 systems. The purpose of this investigation is to explore the basic mechanisms to the replacement process. Thus, while replacement in the presence of real-time deadlines, heterogeneous systems, and unreliable networks is certainly a topic of interest, we will first gain an understanding of the basic processes in the absence of such concerns. The extension of the replacement process to more complex situations can be made later. This report will establish an overview of the on-line upgrade problem, and present a taxonomy of the various aspects of the replacement process.

  12. Visible integration of the adenosine deaminase (ADA) gene into the recipient genome after gene therapy.

    PubMed

    Egashira, M; Ariga, T; Kawamura, N; Miyoshi, O; Niikawa, N; Sakiyama, Y

    1998-01-23

    Gene therapy for patients with adenosine deaminase (ADA) deficiency has become practical in the 1990s, and the exogenous gene has been reported to survive for several years in the recipient genome. To evaluate the integration efficiency of the ADA gene (ADA) into peripheral blood lymphocytes (PBL) of a patient with ADA deficiency who is receiving gene therapy, we performed two-color interphase fluorescence in situ hybridization (FISH) analysis by using digoxigenin-labeled ADA-cDNA and the biotin-labeled lambda-genomic ADA clone as probes. After each of 9 sequential series of gene therapy, interphase nuclei of 100 mononuclear cells from the patient were analyzed, and those of a LASN-producing cell line were used as a control. FISH signals were detected with rhodamine and FITC for the cDNA and the genomic DNA, respectively. The number of PBL giving a transgene signal grew after the sequential gene therapies, and the proportion of signal-positive cells reached about 10%. Our results indicate that the two-color FISH system can be used as a potential aid to monitor the efficiency of the ADA gene therapy.

  13. 12 CFR 575.14 - Subsidiary holding companies.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 6 2012-01-01 2012-01-01 false Subsidiary holding companies. 575.14 Section... COMPANIES § 575.14 Subsidiary holding companies. (a) Subsidiary holding companies. A mutual holding company may establish a subsidiary holding company as a direct subsidiary to hold 100% of the stock of...

  14. 12 CFR 239.11 - Subsidiary holding companies.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 4 2014-01-01 2014-01-01 false Subsidiary holding companies. 239.11 Section... SYSTEM (CONTINUED) MUTUAL HOLDING COMPANIES (REGULATION MM) Mutual Holding Companies § 239.11 Subsidiary holding companies. (a) Subsidiary holding companies. A mutual holding company may establish a...

  15. 12 CFR 575.14 - Subsidiary holding companies.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 6 2014-01-01 2012-01-01 true Subsidiary holding companies. 575.14 Section 575... COMPANIES § 575.14 Subsidiary holding companies. (a) Subsidiary holding companies. A mutual holding company may establish a subsidiary holding company as a direct subsidiary to hold 100% of the stock of...

  16. 12 CFR 239.11 - Subsidiary holding companies.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 4 2013-01-01 2013-01-01 false Subsidiary holding companies. 239.11 Section... SYSTEM (CONTINUED) MUTUAL HOLDING COMPANIES (REGULATION MM) Mutual Holding Companies § 239.11 Subsidiary holding companies. (a) Subsidiary holding companies. A mutual holding company may establish a...

  17. 12 CFR 575.14 - Subsidiary holding companies.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 5 2011-01-01 2011-01-01 false Subsidiary holding companies. 575.14 Section... COMPANIES § 575.14 Subsidiary holding companies. (a) Subsidiary holding companies. A mutual holding company may establish a subsidiary holding company as a direct subsidiary to hold 100% of the stock of...

  18. 12 CFR 575.14 - Subsidiary holding companies.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Subsidiary holding companies. 575.14 Section... COMPANIES § 575.14 Subsidiary holding companies. (a) Subsidiary holding companies. A mutual holding company may establish a subsidiary holding company as a direct subsidiary to hold 100% of the stock of...

  19. 12 CFR 239.11 - Subsidiary holding companies.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 4 2012-01-01 2012-01-01 false Subsidiary holding companies. 239.11 Section... SYSTEM (CONTINUED) MUTUAL HOLDING COMPANIES (REGULATION MM) Mutual Holding Companies § 239.11 Subsidiary holding companies. (a) Subsidiary holding companies. A mutual holding company may establish a...

  20. 12 CFR 575.14 - Subsidiary holding companies.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 6 2013-01-01 2012-01-01 true Subsidiary holding companies. 575.14 Section 575... COMPANIES § 575.14 Subsidiary holding companies. (a) Subsidiary holding companies. A mutual holding company may establish a subsidiary holding company as a direct subsidiary to hold 100% of the stock of...

  1. 78 FR 2481 - Watco Holdings, Inc., Watco Railroad Company Holdings, Inc., & Watco Acquisition Sub, Inc...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-11

    ... Acquisition Sub, Inc.--Acquisition of Control Exemption--Ann Arbor Railroad, Inc. Watco Holdings, Inc. (Watco Holdings), Watco Railroad Company Holdings, Inc. (Watco Railroad), and Watco Acquisition Sub, Inc. (Merger Sub), all noncarriers, have filed a verified notice of exemption under 49 CFR 1180.2(d)(2) for...

  2. 78 FR 66097 - Acies Corporation, Immtech Pharmaceuticals, Inc., MRU Holdings, Inc., MSTI Holdings, Inc., Nestor...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-04

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION Acies Corporation, Immtech Pharmaceuticals, Inc., MRU Holdings, Inc., MSTI Holdings, Inc., Nestor, Inc., New Generation Holdings, Inc., and Nuevo Financial Center, Inc.; Order of Suspension of Trading October 31, 2013. It appears to...

  3. The European Formal Definition of Ada. A U.S. Perspective

    DTIC Science & Technology

    1988-01-01

    the feasibility of using the AdFD to prove certain aspects of the ACVC test suite. Moreover, it was demonstrated that the AdaFD can be executed. This... AdaFD , it was described in English and correlated with the reference manual. In brief, the maii objective of the project was to produce a concise for...The abstract syntax, ASI, describes the input to the static semantics. In the AdaFD , it consists of a number of algebraic specifications. It

  4. CREASE 6.0 Catalog of Resources for Education in Ada and Software Engineering

    DTIC Science & Technology

    1992-02-01

    MV15000 Honeywell DPS90 HP 720, 800, 835, 925, 1500, 3000, 9000 1-4 Catalog of Resources for Educaion in Ada and Software Engineering (CREASE) Version 6...Resources for Educaion in Ada ad Softwre Egimeering (CRFASE) Version 6 February 1992 14. What other training requirements do you have? Numerous responses. 15...USA phone: (805) 756-1392 e-mail: nwebre@zeus.calpoly.edu 2-13 CasaWe of Resources for Educaion In Ada and Sefuare Engineering (CREASE) version 6

  5. Ada compiler evaluation on the Space Station Freedom Software Support Environment project

    NASA Technical Reports Server (NTRS)

    Badal, D. L.

    1989-01-01

    This paper describes the work in progress to select the Ada compilers for the Space Station Freedom Program (SSFP) Software Support Environment (SSE) project. The purpose of the SSE Ada compiler evaluation team is to establish the criteria, test suites, and benchmarks to be used for evaluating Ada compilers for the mainframes, workstations, and the realtime target for flight- and ground-based computers. The combined efforts and cooperation of the customer, subcontractors, vendors, academia and SIGAda groups made it possible to acquire the necessary background information, benchmarks, test suites, and criteria used.

  6. Collective behaviors of book holding durations

    NASA Astrophysics Data System (ADS)

    Li, Ren-De; Guo, Qiang; Han, Jing-Ti; Liu, Jian-Guo

    2016-10-01

    Duration can directly reflect the collective reading behaviors of library user book holding. In this paper, by introducing the burstiness and memory coefficients, we empirically investigate the collective book holding behavior of three university libraries. The statistical results show that there are similar properties among the students with different backgrounds, presenting the burstiness < B > = - 0.2 and memory < M > = 0.5 for three datasets, which indicates that memory and random effects coexist in student book holding durations. In addition, we analyze the behavior patterns without duplicate durations by merging a series of books borrowed and returned at the same time. The results show the average burstiness B increases to -0.16 and memory M drops to 0.16 for three datasets, which indicates that both duplicate behavior and student's preference affect the memory effect. Furthermore, we present a model which assumes student's next book holding duration follows the previous one with probability p, and with probability 1 - p, the student would hold the book independently. The experimental results show that the presented model can reproduce the burstiness and memory effect of student book holding durations when p = 0.5 for empirical datasets and p = 0.2 for de-duplicate datasets, which indicate that the student's preferential holding behavior occurs with the probability p. This work helps in deeply understanding the regularity of duration-based human behaviors.

  7. AdaBoost-based algorithm for network intrusion detection.

    PubMed

    Hu, Weiming; Hu, Wei; Maybank, Steve

    2008-04-01

    Network intrusion detection aims at distinguishing the attacks on the Internet from normal use of the Internet. It is an indispensable part of the information security system. Due to the variety of network behaviors and the rapid development of attack fashions, it is necessary to develop fast machine-learning-based intrusion detection algorithms with high detection rates and low false-alarm rates. In this correspondence, we propose an intrusion detection algorithm based on the AdaBoost algorithm. In the algorithm, decision stumps are used as weak classifiers. The decision rules are provided for both categorical and continuous features. By combining the weak classifiers for continuous features and the weak classifiers for categorical features into a strong classifier, the relations between these two different types of features are handled naturally, without any forced conversions between continuous and categorical features. Adaptable initial weights and a simple strategy for avoiding overfitting are adopted to improve the performance of the algorithm. Experimental results show that our algorithm has low computational complexity and error rates, as compared with algorithms of higher computational complexity, as tested on the benchmark sample data.

  8. ADA - 60th Scientific Sessions. Immunosuppression and herbal therapeutics.

    PubMed

    Worker, C

    2000-09-01

    The American Diabetes Association (ADA) Scientific Sessions provide a forum for those involved in all aspects of research, care and education in diabetes to discuss better ways of diagnosing the condition and providing the best treatment. Any discourse on diabetes has to involve an examination of lifestyle, since a high-sugar diet, lack of exercise and stress are all known to play roles in the pathogenesis of Type II diabetes. As the problem of obesity in our society increases, particularly within the juvenile population, the incidence of Type II diabetes has also risen, creating an ever-increasing financial burden on care providers worldwide. Furthermore, the diagnosis and treatment of Type I diabetes still remains a serious health issue, severely reducing the quality of life for sufferers and their families. However, a number of high-profile campaigns in the US, as well as alarm at the current cost of diabetes (US 100 billion dollars per year in the US) has led to a significant boost to funding in diabetes research.

  9. Allowance Holdings and Transfers Data Inventory

    EPA Pesticide Factsheets

    The Allowance Holdings and Transfers Data Inventory contains measured data on holdings and transactions of allowances under the NOx Budget Trading Program (NBP), a market-based cap and trade program created to reduce the regional transport of NOx emissions from power plants and other large combustion sources that contribute to ozone nonattainment.The statutory authority leading to the collection of this information comes from Title V of the Clean Air Act. Sustance classes include SO2 and NOx. Data of allowance holdings and transfers are made available in real time.

  10. Human ADA3 regulates RARα transcriptional activity through direct contact between LxxLL motifs and the receptor coactivator pocket

    PubMed Central

    Li, Chia-Wei; Ai, Ni; Dinh, Gia Khanh; Welsh, William J.; Chen, J. Don

    2010-01-01

    The alternation/deficiency in activation-3 (ADA3) is an essential component of the human p300/CBP-associated factor (PCAF) and yeast Spt-Ada-Gcn5-acetyltransferase (SAGA) histone acetyltransferase complexes. These complexes facilitate transactivation of target genes by association with transcription factors and modification of local chromatin structure. It is known that the yeast ADA3 is required for nuclear receptor (NR)-mediated transactivation in yeast cells; however, the role of mammalian ADA3 in NR signaling remains elusive. In this study, we have investigated how the human (h) ADA3 regulates retinoic acid receptor (RAR) α-mediated transactivation. We show that hADA3 interacts directly with RARα in a hormone-dependent manner and this interaction contributes to RARα transactivation. Intriguingly, this interaction involves classical LxxLL motifs in hADA3, as demonstrated by both ‘loss’ and ‘gain’ of function mutations, as well as a functional coactivator pocket of the receptor. Additionally, we show that hADA3 associates with RARα target gene promoter in a hormone-dependent manner and ADA3 knockdown impairs RARβ2 expression. Furthermore, a structural model was established to illustrate an interaction network within the ADA3/RARα complex. These results suggest that hADA3 is a bona fide transcriptional coactivator for RARα, acting through a conserved mechanism involving direct contacts between NR boxes and the receptor’s co-activator pocket. PMID:20413580

  11. Novel hold-release functionality in a P300 brain-computer interface

    NASA Astrophysics Data System (ADS)

    Alcaide-Aguirre, R. E.; Huggins, J. E.

    2014-12-01

    Assistive technology control interface theory describes interface activation and interface deactivation as distinct properties of any control interface. Separating control of activation and deactivation allows precise timing of the duration of the activation. Objective. We propose a novel P300 brain-computer interface (BCI) functionality with separate control of the initial activation and the deactivation (hold-release) of a selection. Approach. Using two different layouts and off-line analysis, we tested the accuracy with which subjects could (1) hold their selection and (2) quickly change between selections. Main results. Mean accuracy across all subjects for the hold-release algorithm was 85% with one hold-release classification and 100% with two hold-release classifications. Using a layout designed to lower perceptual errors, accuracy increased to a mean of 90% and the time subjects could hold a selection was 40% longer than with the standard layout. Hold-release functionality provides improved response time (6-16 times faster) over the initial P300 BCI selection by allowing the BCI to make hold-release decisions from very few flashes instead of after multiple sequences of flashes. Significance. For the BCI user, hold-release functionality allows for faster, more continuous control with a P300 BCI, creating new options for BCI applications.

  12. 76 FR 38124 - Applications for New Awards; Americans With Disabilities Act (ADA) National Network Regional...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-29

    ... National Network Collaborative Research Projects AGENCY: Office of Special Education and Rehabilitative... and Rehabilitation Research (NIDRR)--Disability and Rehabilitation Research Projects and Centers Program--Disability Rehabilitation Research Projects (DRRP)--ADA National Network Regional...

  13. 78 FR 67303 - Americans With Disabilities Act (ADA) Accessibility Guidelines for Buildings and Facilities...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-12

    ... From the Federal Register Online via the Government Publishing Office ARCHITECTURAL AND TRANSPORTATION BARRIERS COMPLIANCE BOARD 36 CFR Part 1191 RIN 3014-AA22 Americans With Disabilities Act (ADA) Accessibility Guidelines for Buildings and Facilities; Architectural Barriers Act (ABA) Accessibility...

  14. CSF ADA Determination in Early Diagnosis of Tuberculous Meningitis in HIV-Infected Patients.

    PubMed

    Ghosh, Gopal Chandra; Sharma, Brijesh; Gupta, B B

    2016-01-01

    Tuberculous and Cryptococcal meningitis are common in HIV patients. A highly specific and sensitive rapid test for diagnosis of Tuberculous meningitis especially in setting of HIV is not available in developing countries where the burden of disease is high. We measured ADA (adenosine deaminase) levels using spectrophotometric method in the CSF of HIV patients with meningitis to differentiate Tuberculous meningitis from meningitis due to other causes. Kruskal-Wallis test was used to compare ADA values between tuberculous meningitis (TBM) and nontuberculous (non-TB) meningitis patients and a receiver-operating characteristic (ROC) analysis curve was drawn from these values. Levels of ADA in the CSF of patients with TBM were significantly higher than those in patients with meningitis due to other causes. CSF ADA level determination with a cut-off value of 6 IU/L was found to be highly specific and fairly sensitive test for the diagnosis of TBM in HIV positive patients.

  15. U.S. Environmental Protection Agency's Robert S. Kerr Environmental Research Center, Ada, Oklahoma

    SciTech Connect

    Farrar-Nagy, S.; Voss, P.; Van Geet, O.

    2006-10-01

    U.S. EPA's Robert S. Kerr Environmental Research Center, Ada, Oklahoma, has reduced its annual energy consumption by 45% by upgrading its building mechanical system and incorporating renewable energy.

  16. The implications of the ADA Amendments Act of 2008 for residency training program administration.

    PubMed

    Regenbogen, Alexandra; Recupero, Patricia R

    2012-01-01

    The Americans with Disabilities Act (ADA) is rarely invoked by medical residents in training. Dr. Martin Jakubowski, a family medicine resident with Asperger's disorder, was dismissed for communicating poorly with patients, peers, and supervisors and for issuing dangerous medical orders. In an attempt to become reinstated, he sued under the ADA (Jakubowski v. The Christ Hospital), arguing that the program had failed to make reasonable accommodation for his disability. The Sixth Circuit Court of Appeals ruled in favor of the hospital, finding that although the doctor was disabled under the ADA, he had failed to demonstrate that he was otherwise qualified for the position. This article comments on the ADA Amendments Act of 2008, the Equal Employment Opportunity Commission (EEOC) guidelines from 2011 and their application to medical residency training, and the Accreditation Council for Graduate Medical Education (ACGME) core competencies as essential job functions.

  17. System testing of a production Ada (trademark) project: The GRODY study

    NASA Technical Reports Server (NTRS)

    Seigle, Jeffrey; Esker, Linda; Shi, Ying-Liang

    1990-01-01

    The use of the Ada language and design methodologies that utilize its features has a strong impact on all phases of the software development project lifecycle. At the National Aeronautics and Space Administration/Goddard Space Flight Center (NASA/GSFC), the Software Engineering Laboratory (SEL) conducted an experiment in parallel development of two flight dynamics systems in FORTRAN and Ada. The teams found some qualitative differences between the system test phases of the two projects. Although planning for system testing and conducting of tests were not generally affected by the use of Ada, the solving of problems found in system testing was generally facilitated by Ada constructs and design methodology. Most problems found in system testing were not due to difficulty with the language or methodology but to lack of experience with the application.

  18. The implementation and use of Ada on distributed systems with high reliability requirements

    NASA Technical Reports Server (NTRS)

    Knight, J. C.

    1987-01-01

    Performance analysis was begin on the Ada implementations. The goal is to supply the system designer with tools that will allow a rational decision to be made about whether a particular implementation can support a given application early in the design cycle. Primary activities were: analysis of the original approach to recovery in distributed Ada programs using the Advanced Transport Operating System (ATOPS) example; review and assessment of the original approach which was found to be capable of improvement; preparation and presentation of a paper at the 1987 Washington DC Ada Symposium; development of a refined approach to recovery that is presently being applied to the ATOPS example; and design and development of a performance assessment scheme for Ada programs based on a flexible user-driven benchmarking system.

  19. Four Possible Steps to Reduce Greenhouse Gas Emissions in Ada, Oklahoma

    EPA Science Inventory

    An overview of federal, state, and city initiatives on climate change are presented. Specific steps for the City of Ada, Oklahoma, are presented. This is an abstract of a proposed presentation and does not necessarily reflect EPA policy.

  20. 12 CFR 1235.5 - Record hold.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... alternative storage method. (d) Access to and retrieval of records during a record hold. The record retention program of each regulated entity or the Office of Finance shall ensure access to and retrieval of...

  1. 12 CFR 1235.5 - Record hold.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... alternative storage method. (d) Access to and retrieval of records during a record hold. The record retention program of each regulated entity or the Office of Finance shall ensure access to and retrieval of...

  2. Holding fixture for variable-contour parts

    NASA Technical Reports Server (NTRS)

    Haynie, C. C.; Packer, P. N.; Zebus, P. P.

    1979-01-01

    Array of vacuum cups on spindles holds parts for safe machining and other processings. Variable-contour part resting on fixture is held firmly enough for machining, coating, or other mechanical treatment.

  3. Surface Hold Advisor Using Critical Sections

    NASA Technical Reports Server (NTRS)

    Law, Caleb Hoi Kei (Inventor); Hsiao, Thomas Kun-Lung (Inventor); Mittler, Nathan C. (Inventor); Couluris, George J. (Inventor)

    2013-01-01

    The Surface Hold Advisor Using Critical Sections is a system and method for providing hold advisories to surface controllers to prevent gridlock and resolve crossing and merging conflicts among vehicles traversing a vertex-edge graph representing a surface traffic network on an airport surface. The Advisor performs pair-wise comparisons of current position and projected path of each vehicle with other surface vehicles to detect conflicts, determine critical sections, and provide hold advisories to traffic controllers recommending vehicles stop at entry points to protected zones around identified critical sections. A critical section defines a segment of the vertex-edge graph where vehicles are in crossing or merging or opposite direction gridlock contention. The Advisor detects critical sections without reference to scheduled, projected or required times along assigned vehicle paths, and generates hold advisories to prevent conflicts without requiring network path direction-of-movement rules and without requiring rerouting, rescheduling or other network optimization solutions.

  4. Flu Tightens Its Hold on The Nation

    MedlinePlus

    ... medlineplus.gov/news/fullstory_163039.html Flu Tightens Its Hold on the Nation It's not too late to get vaccinated, CDC says ... pregnant women -- to get their flu shots before it's too late. "Even though activity is elevated, we ...

  5. ADA Implementation Issues as Discovered through a Literature Survey of Applications Outside the United States

    DTIC Science & Technology

    1992-03-01

    Finnish bank being developed by Nokia • Oil drilling control system managed by Sedco- Forex * Vigile - an industrial installation supervisor project by...the requirements for the degree of MASTER OF SCIENCE IN INFORMATION SYSTEMS from the NAVAL POSTGRADUATE SCHOOL March 1992 Author: Waqen J. Soong...R.iabiity .... ................ 14 8. Support for Large, Multi-author Systems 15 III. ADA ADOPTION AND IMPLEMENTATION .. ......... 17 A. W-Y ADA IS

  6. Gender-specific association of ADA genetic polymorphism with human longevity.

    PubMed

    Napolioni, Valerio; Lucarini, Nazzareno

    2010-08-01

    Aim of this study was to investigate whether the polymorphic ADA (Adenosine Deaminase, EC 3.5.4.4) gene, which determines the cellular level of adenosine and plays a crucial role in the regulation of the immune system and in the control of metabolic rates, is involved in longevity. 884 unrelated healthy individuals (age range 10-106 years, 400 males and 484 females) from central Italy were studied. ADA genotyping was performed by RFLP-PCR. Frequency distributions were compared using the chi-square test and a three-way contingency table analysis by a log linear model was applied to test independence between the variables. We found that ADA influences human life-span in a sex and age specific way. An increased frequency of ADA*2 carriers was found in males aged 80-85, and a decreased frequency in males over 85 (chi(2) = 13.93; df = 3; P = 0.003); significant differences among the age groups was not found in females. A strong interaction among age groups, ADA genotype and sex (G = 15.086; df = 3; P = 0.0017) was found. Males aged 80-85 could be protected from ischemic stroke by higher levels of adenosine (determined by the ADA*2 allele). The decrease of ADA*2 carriers in males over 85 may depend essentially on immunological factors; reduced levels of adenosine protect from asthma and other pulmonary diseases and lead to a reduced activation of inflammatory cells and pro-inflammatory cytokines production. Moreover, the low level of adenosine may potentiate the activity of NK and other cellular effectors against tumor cells. The negligible effect of ADA genetic polymorphism in females suggest a marginal influence of genetic factors in determining longevity in this sex, confirming previous reports.

  7. A-D-A small molecules for solution-processed organic photovoltaic cells.

    PubMed

    Ni, Wang; Wan, Xiangjian; Li, Miaomiao; Wang, Yunchuang; Chen, Yongsheng

    2015-03-25

    A-D-A small molecules have drawn more and more attention in solution-processed organic solar cells due to the advantages of a diversity of structures, easy control of energy levels, etc. Recently, a power conversion efficiency of nearly 10% has been achieved through careful material design and device optimization. This feature article reviews recent representative progress in the design and application of A-D-A small molecules in organic photovoltaic cells.

  8. A study of the portability of an Ada system in the software engineering laboratory (SEL)

    NASA Technical Reports Server (NTRS)

    Jun, Linda O.; Valett, Susan Ray

    1990-01-01

    A particular porting effort is discussed, and various statistics on analyzing the portability of Ada and the total staff months (overall and by phase) required to accomplish the rehost, are given. This effort is compared to past experiments on the rehosting of FORTRAN systems. The discussion includes an analysis of the types of errors encountered during the rehosting, the changes required to rehost the system, experiences with the Alsys IBM Ada compiler, the impediments encountered, and the lessons learned during this study.

  9. The implementation and use of Ada on distributed systems with high reliability requirements

    NASA Technical Reports Server (NTRS)

    Knight, J. C.; Gregory, S. T.; Urquhart, J. I. A.

    1984-01-01

    The use and implementation of Ada (a trade mark of the US Dept. of Defense) in distributed environments in which the hardware are assumed to be unreliable were investigated. The possibility that a distributed system is programmed entirely in Ada so that the individual tasks of the system are unconcerned with which processors they are executing on and failures occurring in the underlying hardware were examined.

  10. Prosthetic Tool For Holding Small Ferromagnetic Parts

    NASA Technical Reports Server (NTRS)

    Norton, William E.; Carden, James R.; Belcher, Jewell G., Jr.; Vest, Thomas W.

    1995-01-01

    Tool attached to prosthetic hand or arm enables user to hold nails, screws, nuts, rivets, and other small ferromagnetic objects on small magnetic tip. Device adjusted to hold nail or screw at proper angle for hammering or for use of screwdriver, respectively. Includes base connector with threaded outer surface and lower male member inserted in standard spring-action, quick-connect/quick-disconnect wrist adapter on prosthetic hand or arm.

  11. Four domains of Ada1 form a heterochromatin boundary through different mechanisms.

    PubMed

    Kamata, Kazuma; Shinmyozu, Kaori; Nakayama, Jun-Ichi; Hatashita, Masanori; Uchida, Hiroyuki; Oki, Masaya

    2016-10-01

    In eukaryotic cells, there are two chromatin states, silenced and active, and the formation of a so-called boundary plays a critical role in demarcating these regions; however, the mechanisms underlying boundary formation are not well understood. In this study, we focused on S. cerevisiae ADA1, a gene previously shown to encode a protein with a robust boundary function. Ada1 is a component of the histone modification complex Spt-Ada-Gcn5-acetyltransferase (SAGA) and the SAGA-like (SLIK) complex, and it helps to maintain the integrity of these complexes. Domain analysis showed that four relatively small regions of Ada1 (Region I; 66-75 aa, II; 232-282 aa, III; 416-436 aa and IV; 476-488 aa) have a boundary function. Among these, Region II could form an intact SAGA complex, whereas the other regions could not. Investigation of cellular factors that interact with these small regions identified a number of proteasome-associated proteins. Interestingly, the boundary functions of Region II and Region III were affected by depletion of Ump1, a maturation and assembly factor of the 20S proteasome. These results suggest that the boundary function of Ada1 is functionally linked to proteasome processes and that the four relatively small regions in ADA1 form a boundary via different mechanisms.

  12. Ada response - a strategy for repair of alkylated DNA in bacteria.

    PubMed

    Mielecki, Damian; Grzesiuk, Elżbieta

    2014-06-01

    Alkylating agents are widespread in the environment and also occur endogenously. They can be cytotoxic or mutagenic to the cells introducing alkylated bases to DNA or RNA. All organisms have evolved multiple DNA repair mechanisms to counteract the effects of DNA alkylation: the most cytotoxic lesion, N(3)-methyladenine (3meA), is excised by AlkA glycosylase initiating base excision repair (BER); toxic N(1)-methyladenine (1meA) and N(3)-methylcytosine (3meC), induced in DNA and RNA, are removed by AlkB dioxygenase; and mutagenic and cytotoxic O(6)-methylguanine (O(6) meG) is repaired by Ada methyltransferase. In Escherichia coli, Ada response involves the expression of four genes, ada, alkA, alkB, and aidB, encoding respective proteins Ada, AlkA, AlkB, and AidB. The Ada response is conserved among many bacterial species; however, it can be organized differently, with diverse substrate specificity of the particular proteins. Here, an overview of the organization of the Ada regulon and function of individual proteins is presented. We put special effort into the characterization of AlkB dioxygenases, their substrate specificity, and function in the repair of alkylation lesions in DNA/RNA.

  13. Inhibition of adenosine deaminase (ADA)-mediated metabolism of cordycepin by natural substances.

    PubMed

    Li, Gen; Nakagome, Izumi; Hirono, Shuichi; Itoh, Tomoo; Fujiwara, Ryoichi

    2015-03-01

    Cordycepin, which is an analogue of a nucleoside adenosine, exhibits a wide variety of pharmacological activities including anticancer effects. In this study, ADA1- and ADA2-expressing HEK293 cells were established to determine the major ADA isoform responsible for the deamination of cordycepin. While the metabolic rate of cordycepin deamination was similar between ADA2-expressing and Mock cells, extensive metabolism of cordycepin was observed in the ADA1-expressing cells with K m and V max values of 54.9 μmol/L and 45.8 nmole/min/mg protein. Among five natural substances tested in this study (kaempferol, quercetin, myricetin, naringenin, and naringin), naringin strongly inhibited the deamination of cordycepin with K i values of 58.8 μmol/L in mouse erythrocytes and 168.3 μmol/L in human erythrocytes. A treatment of Jurkat cells with a combination of cordycepin and naringin showed significant cytotoxicity. Our in silico study suggests that not only small molecules such as adenosine derivatives but also bulky molecules like naringin can be a potent ADA1 inhibitor for the clinical usage.

  14. Combinatorial depletion analysis to assemble the network architecture of the SAGA and ADA chromatin remodeling complexes.

    PubMed

    Lee, Kenneth K; Sardiu, Mihaela E; Swanson, Selene K; Gilmore, Joshua M; Torok, Michael; Grant, Patrick A; Florens, Laurence; Workman, Jerry L; Washburn, Michael P

    2011-07-05

    Despite the availability of several large-scale proteomics studies aiming to identify protein interactions on a global scale, little is known about how proteins interact and are organized within macromolecular complexes. Here, we describe a technique that consists of a combination of biochemistry approaches, quantitative proteomics and computational methods using wild-type and deletion strains to investigate the organization of proteins within macromolecular protein complexes. We applied this technique to determine the organization of two well-studied complexes, Spt-Ada-Gcn5 histone acetyltransferase (SAGA) and ADA, for which no comprehensive high-resolution structures exist. This approach revealed that SAGA/ADA is composed of five distinct functional modules, which can persist separately. Furthermore, we identified a novel subunit of the ADA complex, termed Ahc2, and characterized Sgf29 as an ADA family protein present in all Gcn5 histone acetyltransferase complexes. Finally, we propose a model for the architecture of the SAGA and ADA complexes, which predicts novel functional associations within the SAGA complex and provides mechanistic insights into phenotypical observations in SAGA mutants.

  15. Constructing a working taxonomy of functional Ada software components for real-time embedded system applications

    NASA Technical Reports Server (NTRS)

    Wallace, Robert

    1986-01-01

    A major impediment to a systematic attack on Ada software reusability is the lack of an effective taxonomy for software component functions. The scope of all possible applications of Ada software is considered too great to allow the practical development of a working taxonomy. Instead, for the purposes herein, the scope of Ada software application is limited to device and subsystem control in real-time embedded systems. A functional approach is taken in constructing the taxonomy tree for identified Ada domain. The use of modular software functions as a starting point fits well with the object oriented programming philosophy of Ada. Examples of the types of functions represented within the working taxonomy are real time kernels, interrupt service routines, synchronization and message passing, data conversion, digital filtering and signal conditioning, and device control. The constructed taxonomy is proposed as a framework from which a need analysis can be performed to reveal voids in current Ada real-time embedded programming efforts for Space Station.

  16. Ada (Trade Name) Compiler Validation Summary Report: TeleSoft, Inc. TeleSoft Ada, Version 2.39 Gould PS3000 Host, Gould CONCEPT/32 (Trade Name) Model 6750 Target.

    DTIC Science & Technology

    1985-11-08

    B38103C3 315H.E / B35A01ATS P 310C C3570D5K-.DEP N/A B3 610IA- ABADA P B38103C2BAD C C35 705J-B.DEP N/A B35A03A.ADA P B38iO5kBAD~A P C3570514...C1432111C-B.ADA P 8115207U- ABADA P C141303C-B.ADA P C�-B.ADA P D- 7 COMPLETE LIST OF TESTS AND RESULTS C11321’E-B.ADA P C45241X-B.DEP N/A C1151...B58003B-AB.AflA P B52002B-AB.ADA P B511B040-AB.ADA P B59001A-AB.ADA P B52002C- ABADA P B54B05A-AB.ADA P B59001C-AB.ADA P B52002D- ABADA P B55AOlA

  17. ADA Compiler Validation Summary Report: Certificate Number: 880624W1. 09119, R. R. Software, Inc., JANUS/Ada, 2.0.2, IBM PS/2, Model 80

    DTIC Science & Technology

    1988-07-01

    compiler(s) listed in this declaration shall be made only in the oner’s corporate name. .. R. Softwa e, Inc. / ’ Jmes A. ewart, General Manager Owner’s...objects of the type. F.4 Restrictions on Representation Clauses JANUS/Ada representation clauses are currently rather unpretentious. Specifically, JANUSi

  18. Cross Sections: No. 1 Hold section at Fr 24 Looking ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Cross Sections: No. 1 Hold section at Fr 24 Looking Fwd, No 1 Hold Section at Fr 28 Looking Aft, No 2 Hold Section at Fr 48 Looking Aft, No 3 Hold Section at Fr 70 Looking Aft, No 4 Hold Section at Fr 90 Looking Aft - General John Pope, Suisun Bay Reserve Fleet, Benicia, Solano County, CA

  19. 49 CFR 178.338-9 - Holding time.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Holding time. 178.338-9 Section 178.338-9... Containers for Motor Vehicle Transportation § 178.338-9 Holding time. (a) “Holding time” is the time, as...) Holding time test. (1) The test to determine holding time must be performed by charging the tank with...

  20. 49 CFR 178.338-9 - Holding time.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Holding time. 178.338-9 Section 178.338-9... Containers for Motor Vehicle Transportation § 178.338-9 Holding time. (a) “Holding time” is the time, as...) Holding time test. (1) The test to determine holding time must be performed by charging the tank with...

  1. 77 FR 48550 - Sears Holdings Management Corporation, A Division of Sears Holdings Corporation, Hoffman Estates...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-14

    ... Corporation, Hoffman Estates, IL; Notice of Affirmative Determination Regarding Application for... workers at the Hoffman Estates, Illinois facility are similarly situated as the Sears Holdings workers...

  2. Modification of Eccentric Gaze-Holding

    NASA Technical Reports Server (NTRS)

    Reschke, M. F.; Paloski, W. H.; Somers, J. T.; Leigh, R. J.; Wood, S. J.; Kornilova, L.

    2006-01-01

    Clear vision and accurate localization of objects in the environment are prerequisites for reliable performance of motor tasks. Space flight confronts the crewmember with a stimulus rearrangement that requires adaptation to function effectively with the new requirements of altered spatial orientation and motor coordination. Adaptation and motor learning driven by the effects of cerebellar disorders may share some of the same demands that face our astronauts. One measure of spatial localization shared by the astronauts and those suffering from cerebellar disorders that is easily quantified, and for which a neurobiological substrate has been identified, is the control of the angle of gaze (the "line of sight"). The disturbances of gaze control that have been documented to occur in astronauts and cosmonauts, both in-flight and postflight, can be directly related to changes in the extrinsic gravitational environment and intrinsic proprioceptive mechanisms thus, lending themselves to description by simple non-linear statistical models. Because of the necessity of developing robust normal response populations and normative populations against which abnormal responses can be evaluated, the basic models can be formulated using normal, non-astronaut test subjects and subsequently extended using centrifugation techniques to alter the gravitational and proprioceptive environment of these subjects. Further tests and extensions of the models can be made by studying abnormalities of gaze control in patients with cerebellar disease. A series of investigations were conducted in which a total of 62 subjects were tested to: (1) Define eccentric gaze-holding parameters in a normative population, and (2) explore the effects of linear acceleration on gaze-holding parameters. For these studies gaze-holding was evaluated with the subjects seated upright (the normative values), rolled 45 degrees to both the left and right, or pitched back 30 and 90 degrees. In a separate study the further

  3. Technology

    ERIC Educational Resources Information Center

    Isman, Aytekin

    2003-01-01

    This article begins by drawing on literature to examine the various definitions of "technology" and "technique." Following a discussion of the origin of technology in education, the remaining sections of the article focus on the relationships and interaction between: (1) machines and technique; (2) science and technique; (3)…

  4. Technology.

    ERIC Educational Resources Information Center

    Giorgis, Cyndi; Johnson, Nancy J.

    2002-01-01

    Presents annotations of 30 works of children's literature that support the topic of technology and its influences on readers' daily lives. Notes some stories tell about a time when simple tools enabled individuals to accomplish tasks, and others feature visionaries who used technology to create buildings, bridges, roads, and inventions. Considers…

  5. Ada compiler validation summary report. Certificate number: 891116W1. 10191. Intel Corporation, IPSC/2 Ada, Release 1. 1, IPSC/2 parallel supercomputer, system resource manager host and IPSC/2 parallel supercomputer, CX-1 nodes target

    SciTech Connect

    Not Available

    1989-11-16

    This VSR documents the results of the validation testing performed on an Ada compiler. Testing was carried out for the following purposes: To attempt to identify any language constructs supported by the compiler that do not conform to the Ada Standard; To attempt to identify any language constructs not supported by the compiler but required by the Ada Standard; and To determine that the implementation-dependent behavior is allowed by the Ada Standard. Testing of this compiler was conducted by SofTech, Inc. under the direction of he AVF according to procedures established by the Ada Joint Program Office and administered by the Ada Validation Organization (AVO). On-side testing was completed 16 November 1989 at Aloha OR.

  6. Adenosine ecto-deaminase (ecto-ADA) from porcine cerebral cortex synaptic membrane.

    PubMed

    Romanowska, Małgorzata; Ostrowska, Marta; Komoszyński, Michał A

    2007-07-02

    We have purified and investigated the role of adenosine ecto-deaminase (ecto-ADA) in porcine brain synaptic membranes and found a low activity of ecto-ADA in synaptic preparations from the cerebral cortex, hippocampus, striatum and medulla oblongata in the presence of purine transport inhibitors (NBTI, dipyridamole and papaverine). The purification procedure with affinity chromatography on epoxy-Toyopearl gel/purine riboside column as a crucial step of purification allowed a 214-fold purification of synaptic ecto-ADA with a yield of 30%. Gel filtration chromatography revealed a molecular mass estimated at 42.4+/-3.9 kDa. The enzyme had a broad optimum pH and was not affected by mono- and divalent cations. Ecto-ADA revealed a low affinity to adenosine (Ado) and 2'-deoxyadenosine (2'-dAdo) (K(M)=286.30+/-40.38 microM and 287.14+/-46.50 microM, respectively). We compared the affinity of ecto-ADA to the substrates with the physiological and pathological concentrations of the extracellular Ado in brains that do not exceed a low micromolar range even during ischemia and hypoxia, and with the affinity of adenosine receptors to Ado not exceeding a low nanomolar (A(1) and A(2A) receptors) or low micromolar (A(2B) and A(3)) range. Taken together, our data suggest that the role of synaptic ecto-ADA in the regulation of the ecto-Ado level in the brain and in the termination of adenosine receptor signaling is questionable. The porcine brain synapses must have other mechanisms for the ecto-Ado removal from the synaptic cleft and synaptic ecto-ADA may also play an extra-enzymatic role in cell adhesion and non-enzymatic regulation of adenosine receptor activity.

  7. Holding the Edge: Maintaining the Defense Technology Base. Summary

    DTIC Science & Technology

    1989-04-01

    Intelligence Agency, the Defense Logistics Agency, and the National Security Agency. Among the agencies, DARPA occupies a special place because of its role as...moving offshore due to foreign busines andcanrsimy o ot hed ariesr competition. Some have almost vanished, others bns tecnlogcasl, but egal...and other arguments, we are tion in Japan where prices are kept artificially each other’s largest trading partners. Canada is high. The closed

  8. Ada Compiler Validation Summary Report: Certificate Number 880608S1. 09144, Honeywell Bull, GCOS 8 Ada Compiler, Version 2.1, DPS 8000, DPS 8/70, DPS 90 (Target)

    DTIC Science & Technology

    1988-06-08

    Compiler Validation Capability, ACVC, Validation Testing, Ada Validation Office, AVO , Ada Validation Facility, AVF, ANSI/MIL-STD- 1815A, Ada Joint Program...3-2 3 .4 W TESTS ................. 3-2 3 .5 INAPPI.CABLE TESIS ................ 3-2 3.6 TEST, PROCESSING, AND EVALUATItON MOIFICATIONS . . 3-4...Validation Organization ( AVO ). On-site testing was cmpleted 8 June 1988, at Honeywell Bull Corporation, Pnoenix, Arizona. 1. 2 USE OF THIS VALIDATION SUMR

  9. Ada Compiler Validation Summary Report: Certificate Number: 890412I1. 10082 TARTAN Laboratories Incorporated. TARTAN Ada Sun/Sun Version 2.1 Sun 3/60 Host and Target

    DTIC Science & Technology

    1989-04-12

    identification number having the form AI-ddddd. Ada Standard ANSI/NIL-STD-1815A, February 1983 and ISO 8652-1987. Applicant The agency requesting...to Military Standard. Ada Programming Language. ANSI/MIL-STD-1815A (American National Standards Institute, Inc., February 17. 1983 ). 5.1. PRAGMAS...file with multiple compilation units may result in more thanone of each of these files. Their names are derived from the Ada name of the compilation

  10. Decompression sickness following breath-hold diving.

    PubMed

    Schipke, J D; Gams, E; Kallweit, Oliver

    2006-01-01

    Despite convincing evidence of a relationship between breath-hold diving and decompression sickness (DCS), the causal connection is only slowly being accepted. Only the more recent textbooks have acknowledged the risks of repetitive breath-hold diving. We compare four groups of breath-hold divers: (1) Japanese and Korean amas and other divers from the Pacific area, (2) instructors at naval training facilities, (3) spear fishers, and (4) free-dive athletes. While the number of amas is likely decreasing, and Scandinavian Navy training facilities recorded only a few accidents, the number of spear fishers suffering accidents is on the rise, in particular during championships or using scooters. Finally, national and international associations (e.g., International Association of Free Drives [IAFD] or Association Internationale pour Le Developpment De L'Apnee [AIDA]) promote free-diving championships including deep diving categories such as constant weight, variable weight, and no limit. A number of free-diving athletes, training for or participating in competitions, are increasingly accident prone as the world record is presently set at a depth of 171 m. This review presents data found after searching Medline and ISI Web of Science and using appropriate Internet search engines (e.g., Google). We report some 90 cases in which DCS occurred after repetitive breath-hold dives. Even today, the risk of suffering from DCS after repetitive breath-hold diving is often not acknowledged. We strongly suggest that breath-hold divers and their advisors and physicians be made aware of the possibility of DCS and of the appropriate therapeutic measures to be taken when DCS is suspected. Because the risk of suffering from DCS increases depending on depth, bottom time, rate of ascent, and duration of surface intervals, some approaches to assess the risks are presented. Regrettably, none of these approaches is widely accepted. We propose therefore the development of easily manageable

  11. Ada (Trade Name) Compiler Validation Summary Report: Verdix Corporation VAda-010-03315, Version 5.5 MicroVAX II Host iSBC 386/20P Intel Target.

    DTIC Science & Technology

    1987-06-19

    Programming language, Ada Compiler Validation Summary Report, Ada % Compiler Validation Capability, ACVC, Validation Testing, Ada % Validation Office, AVO , Ada...the direction of the Ada lalJation Facility (AVF), according to Ada Validation Organization ( AVO ) polic ’’* and procedures. The AVF identified 2210 of...the AVF according to policies and procedures established by the Ada Validation Organization ( AVO ). On-site testing was conducted from 12 Jun.e 1987

  12. Ada Compiler Validation Summary Report: Meridian Software Systems, Inc., AdaVantage, Version 3.0, SCI 302 (with Floating Point Co-Processor) (Host and Target), 890405W1.10054

    DTIC Science & Technology

    1989-04-05

    Validation Office, AVO , Ada Validation Facility, AVF, A;Si/Y.L-S7D- 1815A, Ada Joint Program~ Office, A3PD Z.ABST&RZ T (Conisnue, on reverie Sidf...established by the Ada Joint Program Office and administered by the Ada Validation Organization ( AVO ). On-site testing was completed 5 April 1989 at Laguana...Hills CA. 1.2 USE OF THIS VALIDATION SUMMARY REPORT Consistent with the national laws of the originating country, the AVO may make full and free

  13. Ada Compiler Validation Summary Report: Certificate Number: 900125N1. 10258, R. R. Software, Inc., Janus/Ada 2.1.3 386 to DOS Bell 386 Under Ms-Dos 4 Host

    DTIC Science & Technology

    1990-01-25

    Ada Validation Vabkdim Swmy Re t AVF-VSR-90502/69 R R Softmm Im 3MW/Ada 21.3 316 to DOS chaplerl - Page I of 5 INTRODUCTION Organization ( AVO ). On...1.2 USE OF THIS VALIDATION SUMMARY REPORT Consistent with the national laws of the originating country, the AVO may make full and free public...contained in the Ada Compiler Validation Procedures and Guidelines. AVO The Ada Validation Organization. The AVO has oversight authority over all AVF

  14. Ada Compiler Validation Summary Report: Certificate Number: 890420W1. 10074 International Business Machines Corporation, IBM Development System for the Ada Language MVS Ada Compiler, Version 2.1.1 IBM 4381 (Host and Target)

    DTIC Science & Technology

    1989-04-20

    20. ARS1AAI . (Contimne on reverse side olnetessary *rwenPtif) by bfoci nur~be’) International Business Machines Corporation, IBM Development System...Number: AVF-VSR-261.0789 89-01-26-TEL Ada COMPILER VALIDATION SUMMARY REPORT: Certificate Number: 890420W1.10074 International Business Machines...computer. The compiler was tested using command scripts provided by International Business Machines Corporation and reviewed by the validation team. The

  15. QUEST/Ada (query utility environment for software testing of Ada: The development of a program analysis environment for Ada, task 1, phase 3

    NASA Technical Reports Server (NTRS)

    Brown, David B.

    1991-01-01

    The results of research and development efforts of the first six months of Task 1, Phase 3 of the project are presented. The goals of Phase 3 are: (1) to further refine the rule base and complete the comparative rule base evaluation; (2) to implement and evaluate a concurrency testing prototype; (3) to convert the complete (unit-level and concurrency) testing prototype to a workstation environment; and (4) to provide a prototype development document to facilitate the transfer of research technology to a working environment. These goals were partially met and the results are summarized.

  16. Autologous transplants of Adipose-Derived Adult Stromal (ADAS) cells afford dopaminergic neuroprotection in a model of Parkinson's disease.

    PubMed

    McCoy, Melissa K; Martinez, Terina N; Ruhn, Kelly A; Wrage, Philip C; Keefer, Edward W; Botterman, Barry R; Tansey, Keith E; Tansey, Malú G

    2008-03-01

    Adult adipose contains stromal progenitor cells with neurogenic potential. However, the stability of neuronal phenotypes adopted by Adipose-Derived Adult Stromal (ADAS) cells and whether terminal neuronal differentiation is required for their consideration as alternatives in cell replacement strategies to treat neurological disorders is largely unknown. We investigated whether in vitro neural induction of ADAS cells determined their ability to neuroprotect or restore function in a lesioned dopaminergic pathway. In vitro-expanded naïve or differentiated ADAS cells were autologously transplanted into substantia nigra 1 week after an intrastriatal 6-hydroxydopamine injection. Neurochemical and behavioral measures demonstrated neuroprotective effects of both ADAS grafts against 6-hydroxydopamine-induced dopaminergic neuron death, suggesting that pre-transplantation differentiation of the cells does not determine their ability to survive or neuroprotect in vivo. Therefore, we investigated whether equivalent protection by naïve and neurally-induced ADAS grafts resulted from robust in situ differentiation of both graft types into dopaminergic fates. Immunohistological analyses revealed that ADAS cells did not adopt dopaminergic cell fates in situ, consistent with the limited ability of these cells to undergo terminal differentiation into electrically active neurons in vitro. Moreover, re-exposure of neurally-differentiated ADAS cells to serum-containing medium in vitro confirmed ADAS cell phenotypic instability (plasticity). Lastly, given that gene expression analyses of in vitro-expanded ADAS cells revealed that both naïve and differentiated ADAS cells express potent dopaminergic survival factors, ADAS transplants may have exerted neuroprotective effects by production of trophic factors at the lesion site. ADAS cells may be ideal for ex vivo gene transfer therapies in Parkinson's disease treatment.

  17. Biodegradation and aquatic toxicity of beta-alaninediacetic acid (beta-ADA).

    PubMed

    Nitschke, L; Wilk, A; Cammerer, C; Lind, G; Metzner, G

    1997-02-01

    The aquatic toxicity and biodegradability of the new chelating agent beta-alaninediacetic acid (beta-ADA) were investigated. There is no inhibition effect of beta-ADA in the daphnia magna 24 h test up to a concentration of 1000 mg/L. The algal growth inhibition test resulted in an EC 50 of 19.7 mg/L. An EC 20 of 740 mg/L was determined in the luminescent bacteria test. An EC 50 was not obtained in this test up to a concentration of 2000 mg/L beta-ADA. The degree of biodegradation of beta-ADA was determined in a static and a continuous test. The beta-ADA removal reached 98% at the end of the test after eight weeks in the continuous test which was carried out with laboratory activated sludge units simulating a waste water treatment plant. Further, biodegradation and toxicity tests were coupled, i.e. the effluents of the laboratory activated sludge units were applied in the toxicity tests. A higher toxicity of the effluents of the test units in comparison with the control unit was not observed.

  18. Assessment of adenosine deaminase (ADA) activity and oxidative stress in patients with chronic tonsillitis.

    PubMed

    Garca, Mehmet Fatih; Demir, Halit; Turan, Mahfuz; Bozan, Nazım; Kozan, Ahmet; Belli, Şeyda Bayel; Arslan, Ayşe; Cankaya, Hakan

    2014-06-01

    To emphasize the effectiveness of adenosine deaminase (ADA) enzyme, which has important roles in the differentiation of lymphoid cells, and oxidative stress in patients with chronic tonsillitis. Serum and tissue samples were obtained from 25 patients who underwent tonsillectomy due to recurrent episodes of acute tonsillitis. In the control group, which also had 25 subjects, only serum samples were taken as obtaining tissue samples would not have been ethically appropriate. ADA enzyme activity, catalase (CAT), carbonic anhydrase (CA), nitric oxide (NO) and malondialdehyde (MDA) were measured in the serum and tissue samples of patients and control group subjects. The serum values of both groups were compared. In addition, the tissue and serum values of patients were compared. Serum ADA activity and the oxidant enzymes MDA and NO values of the patient group were significantly higher than those of the control group (p < 0.001), the antioxidant enzymes CA and CAT values of the patient group were significantly lower than those of the control group (p < 0.001). In addition, while CA, CAT and NO enzyme levels were found to be significantly higher in the tonsil tissue of the patient group when compared to serum levels (p < 0.05), there was no difference between tissue and serum MDA and ADA activity (p > 0.05). Elevated ADA activity may be effective in the pathogenesis of chronic tonsillitis both by impairing tissue structure and contributing to SOR formation.

  19. Platelet aggregation and serum adenosine deaminase (ADA) activity in pregnancy associated with diabetes, hypertension and HIV.

    PubMed

    Leal, Claudio A M; Leal, Daniela B R; Adefegha, Stephen A; Morsch, Vera M; da Silva, José E P; Rezer, João F P; Schrekker, Clarissa M L; Abdalla, Faida H; Schetinger, Maria R C

    2016-07-01

    Platelet aggregation and adenosine deaminase (ADA) activity were evaluated in pregnant women living with some disease conditions including hypertension, diabetes mellitus and human immunodeficiency virus infection. The subject population is consisted of 15 non-pregnant healthy women [control group (CG)], 15 women with normal pregnancy (NP), 7 women with hypertensive pregnancy (HP), 10 women with gestational diabetes mellitus (GDM) and 12 women with human immunodeficiency virus-infected pregnancy (HIP) groups. The aggregation of platelets was checked using an optical aggregometer, and serum ADA activity was determined using the colorimetric method. After the addition of 5 µM of agonist adenosine diphosphate, the percentage of platelet aggregation was significantly (p < 0·05) increased in NP, HP, GDM and HIP groups when compared with the CG, while the addition of 10 µM of the same agonist caused significant (p < 0·05) elevations in HP, GDM and HIP groups when compared with CG. Furthermore, ADA activity was significantly (p < 0·05) enhanced in NP, HP, GDM and HIP groups when compared with CG. In this study, the increased platelet aggregation and ADA activity in pregnancy and pregnancy-associated diseases suggest that platelet aggregation and ADA activity could serve as peripheral markers for the development of effective therapy in the maintenance of homeostasis and some inflammatory process in these pathophysiological conditions. Copyright © 2016 John Wiley & Sons, Ltd.

  20. Combinatorial depletion analysis to assemble the network architecture of the SAGA and ADA chromatin remodeling complexes

    PubMed Central

    Lee, Kenneth K; Sardiu, Mihaela E; Swanson, Selene K; Gilmore, Joshua M; Torok, Michael; Grant, Patrick A; Florens, Laurence; Workman, Jerry L; Washburn, Michael P

    2011-01-01

    Despite the availability of several large-scale proteomics studies aiming to identify protein interactions on a global scale, little is known about how proteins interact and are organized within macromolecular complexes. Here, we describe a technique that consists of a combination of biochemistry approaches, quantitative proteomics and computational methods using wild-type and deletion strains to investigate the organization of proteins within macromolecular protein complexes. We applied this technique to determine the organization of two well-studied complexes, Spt–Ada–Gcn5 histone acetyltransferase (SAGA) and ADA, for which no comprehensive high-resolution structures exist. This approach revealed that SAGA/ADA is composed of five distinct functional modules, which can persist separately. Furthermore, we identified a novel subunit of the ADA complex, termed Ahc2, and characterized Sgf29 as an ADA family protein present in all Gcn5 histone acetyltransferase complexes. Finally, we propose a model for the architecture of the SAGA and ADA complexes, which predicts novel functional associations within the SAGA complex and provides mechanistic insights into phenotypical observations in SAGA mutants. PMID:21734642

  1. The inclusion of ADA-SCID in expanded newborn screening by tandem mass spectrometry.

    PubMed

    la Marca, Giancarlo; Giocaliere, Elisa; Malvagia, Sabrina; Funghini, Silvia; Ombrone, Daniela; Della Bona, Maria Luisa; Canessa, Clementina; Lippi, Francesca; Romano, Francesca; Guerrini, Renzo; Resti, Massimo; Azzari, Chiara

    2014-01-01

    Severe combined immunodeficiency due to adenosine-deaminase defect (ADA-SCID) is usually deadly in childhood because of severe recurrent infections. When clinical diagnosis is done, permanent damages due to infections or metabolite accumulation are often present. Gene therapy, bone marrow transplantation or enzyme replacement therapy may be effective if started early. The aim of this study was to set-up a robust method suitable for screening with a minimized preparation process and with inexpensive running costs, for diagnosing ADA-SCID by tandem mass spectrometry. ADA-SCID satisfies all the criteria for inclusion in a newborn screening program. We describe a protocol revised to incorporate adenosine and 2-deoxyadenosine testing into an expanded newborn screening program. We assessed the effectiveness of this approach testing dried blood spots from 4 genetically confirmed early-onset and 5 delayed-onset ADA-SCID patients. Reference values were established on 50,000 healthy newborns (deoxyadenosine <0.09μmol/L, adenosine <1.61μmol/L). We also developed a second tier test to distinguish true positives from false positives and improve the positive predictive value of an initial abnormal result. In the first 18 months, the pilot project has identified a newborn with a genetically confirmed defect in adenosine deaminase (ADA) gene. The results show that the method having great simplicity, low cost and low process preparations can be fully applicable to a mass screening program.

  2. Ada (Trade Name) Compiler Validation Summary Report: Alsys Inc., AlsyCOMP 003, V3.1, IBM PC AT.

    DTIC Science & Technology

    1988-06-04

    Summary Report, Ada Compiler Validation Capability, ACVC, Validation Testing, Ada Validation Office, AVO , Ada Validation Facility, AVF, ANSI/MIL-STD...ccordinq ’, Ada Validation Organization ( AVO ) policies * ~ The AVF lt!ntified 2210 of h 2399 tests in ACVC -, .8 to i prccsed during on--situ estLog of...8217, of ie-.ording h i;-1. i ci es i procedure:-" -,... i.-, i hy the .\\da I 11,-ganisation ( AVO ) on-site te.vasg was , .rdcted Erom I Tn j . Lhrough 4

  3. PEG-ADA: an alternative to haploidentical bone marrow transplantation and an adjunct to gene therapy for adenosine deaminase deficiency.

    PubMed

    Hershfield, M S

    1995-01-01

    PEG-ADA is a long-circulating form of adenosine deaminase (ADA) that has been in use for > 8 years as replacement therapy for severe combined immunodeficiency disease due to ADA deficiency. Treatment with PEG-ADA almost completely corrects metabolic abnormalities, allowing the recovery of a variable degree of immune function. Although not normal, the level of function achieved has in most cases been sufficient to protect against opportunistic and life-threatening infections. PEG-ADA has been used as an alternative for patients who lack an HLA-identical bone marrow donor, but are judged to be at too high a risk for undergoing HLA-haploidentical marrow transplantation. To date, mortality and morbidity with PEG-ADA have been less than for the latter procedure. PEG-ADA has also been an important adjunct to attempts to develop somatic cell gene therapy for ADA deficiency, although its continued use poses a problem for evaluation of the benefit of gene therapy. As a true "orphan drug" developed to treat a very small patient population, the cost per patient of PEG-ADA is very high.

  4. Spectrum of mutations in a cohort of UK patients with ADA deficient SCID: Segregation of genotypes with specific ethnicities.

    PubMed

    Adams, Stuart P; Wilson, Melanie; Harb, Elissar; Fairbanks, Lynette; Xu-Bayford, Jinhua; Brown, Lucie; Kearney, Laura; Madkaikar, Manisha; Bobby Gaspar, H

    2015-12-01

    Severe combined immunodeficiency (SCID) arises from a number of different genetic defects, one of the most common being mutations in the gene encoding adenosine deaminase (ADA). In the UK, ADA deficient SCID compromises approximately 20% of all known cases of SCID. We carried out a retrospective analysis of the ADA gene in 46 known ADA deficient SCID patients on whom DNA had been stored. Here, we report a high frequency of two previously reported mutations and provide a link between the mutations and patient ethnicity within our patient cohort. We also report on 9 novel mutations that have been previously unreported.

  5. Acetylation of Mammalian ADA3 Is Required for Its Functional Roles in Histone Acetylation and Cell Proliferation

    PubMed Central

    Mohibi, Shakur; Srivastava, Shashank; Bele, Aditya; Mirza, Sameer; Band, Hamid

    2016-01-01

    Alteration/deficiency in activation 3 (ADA3) is an essential component of specific histone acetyltransferase (HAT) complexes. We have previously shown that ADA3 is required for establishing global histone acetylation patterns and for normal cell cycle progression (S. Mohibi et al., J Biol Chem 287:29442–29456, 2012, http://dx.doi.org/10.1074/jbc.M112.378901). Here, we report that these functional roles of ADA3 require its acetylation. We show that ADA3 acetylation, which is dynamically regulated in a cell cycle-dependent manner, reflects a balance of coordinated actions of its associated HATs, GCN5, PCAF, and p300, and a new partner that we define, the deacetylase SIRT1. We use mass spectrometry and site-directed mutagenesis to identify major sites of ADA3 acetylated by GCN5 and p300. Acetylation-defective mutants are capable of interacting with HATs and other components of HAT complexes but are deficient in their ability to restore ADA3-dependent global or locus-specific histone acetylation marks and cell proliferation in Ada3-deleted murine embryonic fibroblasts (MEFs). Given the key importance of ADA3-containing HAT complexes in the regulation of various biological processes, including the cell cycle, our study presents a novel mechanism to regulate the function of these complexes through dynamic ADA3 acetylation. PMID:27402865

  6. Acetylation of Mammalian ADA3 Is Required for Its Functional Roles in Histone Acetylation and Cell Proliferation.

    PubMed

    Mohibi, Shakur; Srivastava, Shashank; Bele, Aditya; Mirza, Sameer; Band, Hamid; Band, Vimla

    2016-10-01

    Alteration/deficiency in activation 3 (ADA3) is an essential component of specific histone acetyltransferase (HAT) complexes. We have previously shown that ADA3 is required for establishing global histone acetylation patterns and for normal cell cycle progression (S. Mohibi et al., J Biol Chem 287:29442-29456, 2012, http://dx.doi.org/10.1074/jbc.M112.378901). Here, we report that these functional roles of ADA3 require its acetylation. We show that ADA3 acetylation, which is dynamically regulated in a cell cycle-dependent manner, reflects a balance of coordinated actions of its associated HATs, GCN5, PCAF, and p300, and a new partner that we define, the deacetylase SIRT1. We use mass spectrometry and site-directed mutagenesis to identify major sites of ADA3 acetylated by GCN5 and p300. Acetylation-defective mutants are capable of interacting with HATs and other components of HAT complexes but are deficient in their ability to restore ADA3-dependent global or locus-specific histone acetylation marks and cell proliferation in Ada3-deleted murine embryonic fibroblasts (MEFs). Given the key importance of ADA3-containing HAT complexes in the regulation of various biological processes, including the cell cycle, our study presents a novel mechanism to regulate the function of these complexes through dynamic ADA3 acetylation.

  7. Empowerment Amongst Teachers Holding Leadership Positions

    ERIC Educational Resources Information Center

    Avidov-Ungar, Orit; Friedman, Izhak; Olshtain, Elite

    2014-01-01

    This study used semi-structured in-depth interviews to explore empowerment patterns among teachers who hold leadership positions in school. Our qualitative analysis presents a hierarchical ladder with three types of empowerment amongst these teachers, ranging from limited empowerment through rewarding empowerment to change-enhancing empowerment.…

  8. Package Holds Five Monolithic Microwave Integrated Circuits

    NASA Technical Reports Server (NTRS)

    Mysoor, Narayan R.; Decker, D. Richard; Olson, Hilding M.

    1996-01-01

    Packages protect and hold monolithic microwave integrated circuit (MMIC) chips while providing dc and radio-frequency (RF) electrical connections for chips undergoing development. Required to be compact, lightweight, and rugged. Designed to minimize undesired resonances, reflections, losses, and impedance mismatches.

  9. Holding Students Accountable in Team Projects

    ERIC Educational Resources Information Center

    Mentzer, Nathan

    2014-01-01

    This article describes an efficient peer evaluation process that can be implemented at the middle and high school levels, and that holds students accountable for their individual contributions in a team-based project. Teachers faced with this challenge will welcome the web-based peer-evaluation interface that was capable of soliciting student…

  10. 12 CFR 347.110 - Affiliate holdings.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... connection with an underwriting or for distribution or dealing by an affiliate permitted to do so by §§ 362.8 or 362.18 of this chapter or section 4(c)(8) of the Bank Holding Company Act (12 U.S.C. 1843(c)(8))....

  11. The Physics of Breath-Hold Diving.

    ERIC Educational Resources Information Center

    Aguilella, Vicente; Aguilella-Arzo, Marcelo

    1996-01-01

    Analyzes physical features of breath-hold diving. Considers the diver's descent and the initial surface dive and presents examples that show the diver's buoyancy equilibrium varying with depth, the driving force supplied by finning, and the effect of friction between the water and the diver. (Author/JRH)

  12. Holding fixture for a hot stamping press

    NASA Technical Reports Server (NTRS)

    Harris, R. P. (Inventor)

    1983-01-01

    A hand held guide for manually positioning a work piece between the anvil rib and tool of a hot die stamping press is described. A groove completed by interchangeable cover plates attached at one end of the guide conforms to a cross sectional dimension common to similar workpieces and, with a force fit, retentively holds each of the workpieces.

  13. 9 CFR 2.102 - Holding facility.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Holding facility. 2.102 Section 2.102 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL... animals remain under the total control and responsibility of the research facility or intermediate...

  14. Water holding capacity in poultry breast meat.

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The underlying mechanisms that control water-holding capacity (WHC) in pale broiler meat are not well-established. The objectives of the two studies reported here were: 1) to determine the relationship between WHC and protein denaturation in broiler breast meat exhibiting divergent WHC attributes,...

  15. 9 CFR 2.101 - Holding period.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... or cat acquired by a dealer 5 or exhibitor shall be held by him or her, under his or her supervision... considered to have acquired a dog or cat which is sold through the auction sale. (1) That any live dog or cat...) Live dogs or cats which have completed a 5-day holding period with another dealer or exhibitor, or a...

  16. 9 CFR 2.101 - Holding period.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... or cat acquired by a dealer 5 or exhibitor shall be held by him or her, under his or her supervision... considered to have acquired a dog or cat which is sold through the auction sale. (1) That any live dog or cat...) Live dogs or cats which have completed a 5-day holding period with another dealer or exhibitor, or a...

  17. 9 CFR 2.101 - Holding period.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... or cat acquired by a dealer 5 or exhibitor shall be held by him or her, under his or her supervision... considered to have acquired a dog or cat which is sold through the auction sale. (1) That any live dog or cat...) Live dogs or cats which have completed a 5-day holding period with another dealer or exhibitor, or a...

  18. 9 CFR 2.101 - Holding period.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... or cat acquired by a dealer 5 or exhibitor shall be held by him or her, under his or her supervision... considered to have acquired a dog or cat which is sold through the auction sale. (1) That any live dog or cat...) Live dogs or cats which have completed a 5-day holding period with another dealer or exhibitor, or a...

  19. 9 CFR 2.101 - Holding period.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... or cat acquired by a dealer 5 or exhibitor shall be held by him or her, under his or her supervision... considered to have acquired a dog or cat which is sold through the auction sale. (1) That any live dog or cat...) Live dogs or cats which have completed a 5-day holding period with another dealer or exhibitor, or a...

  20. Probabilistic Analysis of Ground-Holding Strategies

    NASA Technical Reports Server (NTRS)

    Sheel, Minakshi

    1997-01-01

    The Ground-Holding Policy Problem (GHPP) has become a matter of great interest in recent years because of the high cost incurred by aircraft suffering from delays. Ground-holding keeps a flight on the ground at the departure airport if it is known it will be unable to land at the arrival airport. The GBPP is determining how many flights should be held on the ground before take-off and for how long, in order to minimize the cost of delays. When the uncertainty associated with airport landing capacity is considered, the GHPP becomes complicated. A decision support system that incorporates this uncertainty, solves the GHPP quickly, and gives good results would be of great help to air traffic management. The purpose of this thesis is to modify and analyze a probabilistic ground-holding algorithm by applying it to two common cases of capacity reduction. A graphical user interface was developed and sensitivity analysis was done on the algorithm, in order to see how it may be implemented in practice. The sensitivity analysis showed the algorithm was very sensitive to the number of probabilistic capacity scenarios used and to the cost ratio of air delay to ground delay. The algorithm was not particularly sensitive to the number of periods that the time horizon was divided into. In terms of cost savings, a ground-holding policy was the most beneficial when demand greatly exceeded airport capacity. When compared to other air traffic flow strategies, the ground-holding algorithm performed the best and was the most consistent under various situations. The algorithm can solve large problems quickly and efficiently on a personal computer.

  1. Ada Compiler Validation Summary Report: Certificate Number: 920509S1. 11259 Alenia Aeritalia and Selenia S.p.A DACS VAX/VMS to 80x86 PM MARA Ada Cross Compiler, Version 4.6 Microvax 4000/200 => MARA

    DTIC Science & Technology

    1992-01-01

    INTERFACE exc. non ADA ------- v codice ADA exception ADA AH A AI .1 I sistema operativo exc. non ADA ------- - fig. 1- Function Exception Handling is...identification of page terminator can be penalized when teletype characterization is used to handle serial communication lines connected to host computers. In

  2. An enhanced Ada run-time system for real-time embedded processors

    NASA Technical Reports Server (NTRS)

    Sims, J. T.

    1991-01-01

    An enhanced Ada run-time system has been developed to support real-time embedded processor applications. The primary focus of this development effort has been on the tasking system and the memory management facilities of the run-time system. The tasking system has been extended to support efficient and precise periodic task execution as required for control applications. Event-driven task execution providing a means of task-asynchronous control and communication among Ada tasks is supported in this system. Inter-task control is even provided among tasks distributed on separate physical processors. The memory management system has been enhanced to provide object allocation and protected access support for memory shared between disjoint processors, each of which is executing a distinct Ada program.

  3. A study of three polymorphic sites of ADA gene in colon cancer.

    PubMed

    Spina, C; Saccucci, P; Cozzoli, E; Bottini, E; Gloria-Bottini, F

    2010-12-01

    Adenosine inhibits the immune response in tumors. Adenosine deaminase (ADA) controls adenosine level and as ecto-enzyme acts as costimulatory molecule of adenosine receptors and/or CD26. We examined ADA₁, ADA₂, ADA₆ polymorphic sites of ADA gene in 109 subjects with colon cancer from Rome's population and in 246 blood donors as controls from the same population. In colon cancer ADA₁*2/ADA₂*1 haplotype is more represented, while ADA₁*2/ADA₂*2 is less represented than in controls. ADA₂*2/ADA₆*2 is less represented in patients than in controls. Polymorphic sites of ADA might influence cell-mediated anti-tumor immune responses controlling adenosine level and extraenzymatic protein functions.

  4. Implementation of and Ada real-time executive: A case study

    NASA Technical Reports Server (NTRS)

    Laird, James D.; Burton, Bruce A.; Koppes, Mary R.

    1986-01-01

    Current Ada language implementations and runtime environments are immature, unproven and are a key risk area for real-time embedded computer system (ECS). A test-case environment is provided in which the concerns of the real-time, ECS community are addressed. A priority driven executive is selected to be implemented in the Ada programming language. The model selected is representative of real-time executives tailored for embedded systems used missile, spacecraft, and avionics applications. An Ada-based design methodology is utilized, and two designs are considered. The first of these designs requires the use of vendor supplied runtime and tasking support. An alternative high-level design is also considered for an implementation requiring no vendor supplied runtime or tasking support. The former approach is carried through to implementation.

  5. Diagnostic value of sputum adenosine deaminase (ADA) level in pulmonary tuberculosis

    PubMed Central

    Binesh, Fariba; Jalali, Hadi; Zare, Mohammad Reza; Behravan, Farhad; Tafti, Arefeh Dehghani; Behnaz, Fatemah; Tabatabaee, Mohammad; Shahcheraghi, Seyed Hossein

    2016-01-01

    Introduction Tuberculosis is still a considerable health problem in many countries. Rapid diagnosis of this disease is important, and adenosine deaminase (ADA) has been used as a diagnostic test. The aim of this study was to assess the diagnostic value of ADA in the sputum of patients with pulmonary tuberculosis. Methods The current study included 40 patients with pulmonary tuberculosis (culture positive, smear ±) and 42 patients with non tuberculosis pulmonary diseases (culture negative). ADA was measured on all of the samples. Results The median value of ADA in non-tuberculosis patients was 2.94 (4.2) U/L and 4.01 (6.54) U/L in tuberculosis patients, but this difference was not statistically significant (p=0.100). The cut-off point of 3.1 U/L had a sensitivity of 61% and a specificity of 53%, the cut-off point of 2.81 U/L had a sensitivity of 64% and a specificity of 50% and the cut-off point of 2.78 U/L had a sensitivity of 65% and a specificity of 48%. The positive predictive values for cut-off points of 3.1, 2.81 and 2.78 U/L were 55.7%, 57.44% and 69.23%, respectively. The negative predictive values for the abovementioned cut-off points were 56.75%, 57.14% and 55.88%, respectively. Conclusion Our results showed that sputum ADA test is neither specific nor sensitive. Because of its low sensitivity and specificity, determination of sputum ADA for the diagnosis of pulmonary tuberculosis is not recommended. PMID:27482515

  6. Comparison of WHO and ADA criteria for diagnosis of glucose status in adults.

    PubMed

    Metcalf, P A; Scragg, R K

    2000-08-01

    The aim was to compare the 1997 American Diabetes Association (ADA) and 1985 and 1998 World Health Organisation (WHO) criteria for the diagnosis of diabetes and impaired glucose tolerance (IGT) by ethnicity and cardiovascular risk factors. We analysed the oral glucose tolerance tests carried out in a cross-sectional survey of 5816 New Zealand workers aged 22-78 years (4211 men, 1605 women) carried out between 1988 and 1990. Prevalence of diabetes was similar using ADA (3.1%) compared with the 1998 WHO criteria (3.0%). The overall prevalence rate of diabetes using the 1985 WHO criteria was only 1.5%. The prevalence rate of impaired fasting glucose (IFG) was the lowest in Europeans (7.3%) and highest in Asians (15.0%). The overall weighted kappa for agreement between the 1997 ADA and 1998 WHO criteria was moderate (0.59), but varied between ethnic groups. Cardiovascular disease (CVD) risk factors were approximately more adverse across groups with IFG, normal (ADA)/IGT (WHO), IFG/IGT and diabetes compared with normal subjects. Compared to those with IFG, participants with the normal (ADA)/IGT (WHO) criteria differed in fasting and 2-h glucose, diastolic blood pressure, and urinary albumin levels, and the proportions of males and number with hypertension, but had a significantly adverse pattern of CVD risk factors compared to those with normal glycaemia. The 1988 WHO criteria using the OGTT provides additional information for classifying various categories of glucose intolerance that is not captured using the 1997 ADA fasting glucose criteria alone.

  7. Diagnosis of tuberculosis pleurisy with adenosine deaminase (ADA): a systematic review and meta-analysis.

    PubMed

    Gui, Xuwei; Xiao, Heping

    2014-01-01

    This systematic review and meta-analysis was performed to determine accuracy and usefulness of adenosine deaminase (ADA) in diagnosis of tuberculosis pleurisy. Medline, Google scholar and Web of Science databases were searched to identify related studies until 2014. Two reviewers independently assessed quality of studies included according to standard Quality Assessment of Diagnosis Accuracy Studies (QUADAS) criteria. The sensitivity, specificity, diagnostic odds ratio and other parameters of ADA in diagnosis of tuberculosis pleurisy were analyzed with Meta-DiSC1.4 software, and pooled using the random effects model. Twelve studies including 865 tuberculosis pleurisy patients and 1379 non-tuberculosis pleurisy subjects were identified from 110 studies for this meta-analysis. The sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR) and diagnosis odds ratio (DOR) of ADA in the diagnosis of tuberculosis pleurisy were 45.25 (95% CI 27.63-74.08), 0.86 (95% CI 0.84-0.88), 0.88 (95% CI 0.86-0.90), 6.32 (95% CI 4.83-8.26) and 0.15 (95% 0.11-0.22), respectively. The area under the summary receiver operating characteristic curve (SROC) was 0.9340. Our results demonstrate that the sensitivity and specificity of ADA are high in the diagnosis of tuberculosis pleurisy especially when ADA≥50 (U/L). Thus, ADA is a relatively sensitive and specific marker for tuberculosis pleurisy diagnosis. However, it is cautious to apply these results due to the heterogeneity in study design of these studies. Further studies are required to confirm the optimal cut-off value of ADA.

  8. Technology.

    ERIC Educational Resources Information Center

    Online-Offline, 1998

    1998-01-01

    Focuses on technology, on advances in such areas as aeronautics, electronics, physics, the space sciences, as well as computers and the attendant progress in medicine, robotics, and artificial intelligence. Describes educational resources for elementary and middle school students, including Web sites, CD-ROMs and software, videotapes, books,…

  9. ADA, the Programming Language of Choice for the UPMSat-2 Satellite

    NASA Astrophysics Data System (ADS)

    Garrido, Jorge; Zamorano, Juan; de la Puente, Juan A.; Alonso, Alejandro; Salazar, Emilio

    2015-09-01

    The proper selection of development mechanisms and tools is essential for the final success of any engineering project. This is also true when it comes to software development. Furthermore, when the system shows very specific and hard to meet requirements, as it happens for high-integrity real-time systems, the appropriate selection is crucial. For this kind of systems, Ada has proven to be a successful companion, and satellites are not an exception. The paper presents the reasons behind the selection of Ada for the UPMSat-2 development, along with the experience and examples on its usage.

  10. The Spectrum Sensing Algorithm Based AdaBoost in Cognitive Radio

    NASA Astrophysics Data System (ADS)

    Tian, Deyong; Wang, Xin

    To solve the low detection rate of the primary user in the cognitive radio environment, we propose a spectrum sensing method based on AdaBoost in the case of low SNR. In this paper, a set of received signal spectrum features are first calculated and extracted the discriminant feature vector as training samples and testing samples for classification. Finally, we utilize the trained AdaBoost to detect the primary user. Test result shows that the proposed algorithm is not affected by uncertainty factors of noise and has high performance to classification detection compared with ANN, SVM and maximum-minimum eigenvalue (MME).

  11. An Ada implementation of the network manager for the advanced information processing system

    NASA Technical Reports Server (NTRS)

    Nagle, Gail A.

    1986-01-01

    From an implementation standpoint, the Ada language provided many features which facilitated the data and procedure abstraction process. The language supported a design which was dynamically flexible (despite strong typing), modular, and self-documenting. Adequate training of programmers requires access to an efficient compiler which supports full Ada. When the performance issues for real time processing are finally addressed by more stringent requirements for tasking features and the development of efficient run-time environments for embedded systems, the full power of the language will be realized.

  12. Cross Sections: No 6 Hold Section at Fr 178 Looking ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Cross Sections: No 6 Hold Section at Fr 178 Looking Fwd, No 7 Hold Section at No 154 Looking Fwd, No 7 Hold Section at Fr 195 Looking Fwd Showing Trans 194, No 7 Hold Section at Fr 198 Looking Fwd - General John Pope, Suisun Bay Reserve Fleet, Benicia, Solano County, CA

  13. 26 CFR 53.4943-8 - Business holdings; constructive ownership.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 17 2010-04-01 2010-04-01 false Business holdings; constructive ownership. 53... Business Holdings § 53.4943-8 Business holdings; constructive ownership. (a) Constructive ownership—(1) In general. For purposes of section 4943, in computing the holdings in a business enterprise of a...

  14. 12 CFR 225.124 - Foreign bank holding companies.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 3 2014-01-01 2014-01-01 false Foreign bank holding companies. 225.124 Section... SYSTEM (CONTINUED) BANK HOLDING COMPANIES AND CHANGE IN BANK CONTROL (REGULATION Y) Regulations Financial Holding Companies Interpretations § 225.124 Foreign bank holding companies. (a) Effective December 1,...

  15. 12 CFR 575.3 - Mutual holding company reorganizations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 6 2014-01-01 2012-01-01 true Mutual holding company reorganizations. 575.3... COMPANIES § 575.3 Mutual holding company reorganizations. A mutual savings association may reorganize to become a mutual holding company, or join in a mutual holding company reorganization as an...

  16. 26 CFR 1.543-1 - Personal holding company income.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 7 2014-04-01 2013-04-01 true Personal holding company income. 1.543-1 Section... (CONTINUED) INCOME TAXES (CONTINUED) Personal Holding Companies § 1.543-1 Personal holding company income. (a) General rule. The term personal holding company income means the portion of the gross income...

  17. 12 CFR 583.4 - Bank holding company.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 6 2012-01-01 2012-01-01 false Bank holding company. 583.4 Section 583.4 Banks... AFFECTING SAVINGS AND LOAN HOLDING COMPANIES § 583.4 Bank holding company. The term bank holding company means any company which has control over any bank or over any company that is or becomes a bank...

  18. 12 CFR 239.3 - Mutual holding company reorganizations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 4 2014-01-01 2014-01-01 false Mutual holding company reorganizations. 239.3... RESERVE SYSTEM (CONTINUED) MUTUAL HOLDING COMPANIES (REGULATION MM) Mutual Holding Companies § 239.3 Mutual holding company reorganizations. (a) A mutual savings association may not reorganize to become...

  19. 26 CFR 1.543-1 - Personal holding company income.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 7 2012-04-01 2012-04-01 false Personal holding company income. 1.543-1 Section... (CONTINUED) INCOME TAXES (CONTINUED) Personal Holding Companies § 1.543-1 Personal holding company income. (a) General rule. The term personal holding company income means the portion of the gross income...

  20. 12 CFR 583.20 - Savings and loan holding company.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 6 2013-01-01 2012-01-01 true Savings and loan holding company. 583.20 Section... REGULATIONS AFFECTING SAVINGS AND LOAN HOLDING COMPANIES § 583.20 Savings and loan holding company. The term savings and loan holding company means any company that directly or indirectly controls a...

  1. 12 CFR 225.124 - Foreign bank holding companies.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 3 2011-01-01 2011-01-01 false Foreign bank holding companies. 225.124 Section... SYSTEM BANK HOLDING COMPANIES AND CHANGE IN BANK CONTROL (REGULATION Y) Regulations Financial Holding Companies Interpretations § 225.124 Foreign bank holding companies. (a) Effective December 1, 1971,...

  2. 12 CFR 583.20 - Savings and loan holding company.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 6 2012-01-01 2012-01-01 false Savings and loan holding company. 583.20... REGULATIONS AFFECTING SAVINGS AND LOAN HOLDING COMPANIES § 583.20 Savings and loan holding company. The term savings and loan holding company means any company that directly or indirectly controls a...

  3. 12 CFR 583.20 - Savings and loan holding company.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 5 2011-01-01 2011-01-01 false Savings and loan holding company. 583.20... REGULATIONS AFFECTING SAVINGS AND LOAN HOLDING COMPANIES § 583.20 Savings and loan holding company. The term savings and loan holding company means any company that directly or indirectly controls a...

  4. 12 CFR 575.3 - Mutual holding company reorganizations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 6 2013-01-01 2012-01-01 true Mutual holding company reorganizations. 575.3... COMPANIES § 575.3 Mutual holding company reorganizations. A mutual savings association may reorganize to become a mutual holding company, or join in a mutual holding company reorganization as an...

  5. 12 CFR 239.3 - Mutual holding company reorganizations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 4 2013-01-01 2013-01-01 false Mutual holding company reorganizations. 239.3... RESERVE SYSTEM (CONTINUED) MUTUAL HOLDING COMPANIES (REGULATION MM) Mutual Holding Companies § 239.3 Mutual holding company reorganizations. (a) A mutual savings association may not reorganize to become...

  6. 26 CFR 1.543-1 - Personal holding company income.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 7 2013-04-01 2013-04-01 false Personal holding company income. 1.543-1 Section... (CONTINUED) INCOME TAXES (CONTINUED) Personal Holding Companies § 1.543-1 Personal holding company income. (a) General rule. The term personal holding company income means the portion of the gross income...

  7. 26 CFR 1.543-1 - Personal holding company income.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 7 2011-04-01 2009-04-01 true Personal holding company income. 1.543-1 Section... (CONTINUED) INCOME TAXES (CONTINUED) Personal Holding Companies § 1.543-1 Personal holding company income. (a) General rule. The term personal holding company income means the portion of the gross income...

  8. 12 CFR 583.4 - Bank holding company.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 6 2014-01-01 2012-01-01 true Bank holding company. 583.4 Section 583.4 Banks... AFFECTING SAVINGS AND LOAN HOLDING COMPANIES § 583.4 Bank holding company. The term bank holding company means any company which has control over any bank or over any company that is or becomes a bank...

  9. 12 CFR 583.4 - Bank holding company.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Bank holding company. 583.4 Section 583.4 Banks... AFFECTING SAVINGS AND LOAN HOLDING COMPANIES § 583.4 Bank holding company. The term bank holding company means any company which has control over any bank or over any company that is or becomes a bank...

  10. 12 CFR 583.20 - Savings and loan holding company.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Savings and loan holding company. 583.20... REGULATIONS AFFECTING SAVINGS AND LOAN HOLDING COMPANIES § 583.20 Savings and loan holding company. The term savings and loan holding company means any company that directly or indirectly controls a...

  11. 12 CFR 575.3 - Mutual holding company reorganizations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Mutual holding company reorganizations. 575.3... COMPANIES § 575.3 Mutual holding company reorganizations. A mutual savings association may reorganize to become a mutual holding company, or join in a mutual holding company reorganization as an...

  12. 12 CFR 575.3 - Mutual holding company reorganizations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 5 2011-01-01 2011-01-01 false Mutual holding company reorganizations. 575.3... COMPANIES § 575.3 Mutual holding company reorganizations. A mutual savings association may reorganize to become a mutual holding company, or join in a mutual holding company reorganization as an...

  13. 12 CFR 225.124 - Foreign bank holding companies.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 3 2013-01-01 2013-01-01 false Foreign bank holding companies. 225.124 Section... SYSTEM (CONTINUED) BANK HOLDING COMPANIES AND CHANGE IN BANK CONTROL (REGULATION Y) Regulations Financial Holding Companies Interpretations § 225.124 Foreign bank holding companies. (a) Effective December 1,...

  14. 26 CFR 1.543-1 - Personal holding company income.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 7 2010-04-01 2010-04-01 true Personal holding company income. 1.543-1 Section... (CONTINUED) INCOME TAXES (CONTINUED) Personal Holding Companies § 1.543-1 Personal holding company income. (a) General rule. The term personal holding company income means the portion of the gross income...

  15. 12 CFR 225.124 - Foreign bank holding companies.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Foreign bank holding companies. 225.124 Section... SYSTEM BANK HOLDING COMPANIES AND CHANGE IN BANK CONTROL (REGULATION Y) Regulations Financial Holding Companies Interpretations § 225.124 Foreign bank holding companies. (a) Effective December 1, 1971,...

  16. 12 CFR 583.4 - Bank holding company.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 6 2013-01-01 2012-01-01 true Bank holding company. 583.4 Section 583.4 Banks... AFFECTING SAVINGS AND LOAN HOLDING COMPANIES § 583.4 Bank holding company. The term bank holding company means any company which has control over any bank or over any company that is or becomes a bank...

  17. 12 CFR 239.3 - Mutual holding company reorganizations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 4 2012-01-01 2012-01-01 false Mutual holding company reorganizations. 239.3... RESERVE SYSTEM (CONTINUED) MUTUAL HOLDING COMPANIES (REGULATION MM) Mutual Holding Companies § 239.3 Mutual holding company reorganizations. (a) A mutual savings association may not reorganize to become...

  18. 12 CFR 225.124 - Foreign bank holding companies.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 3 2012-01-01 2012-01-01 false Foreign bank holding companies. 225.124 Section... SYSTEM BANK HOLDING COMPANIES AND CHANGE IN BANK CONTROL (REGULATION Y) Regulations Financial Holding Companies Interpretations § 225.124 Foreign bank holding companies. (a) Effective December 1, 1971,...

  19. 12 CFR 575.3 - Mutual holding company reorganizations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 6 2012-01-01 2012-01-01 false Mutual holding company reorganizations. 575.3... COMPANIES § 575.3 Mutual holding company reorganizations. A mutual savings association may reorganize to become a mutual holding company, or join in a mutual holding company reorganization as an...

  20. 12 CFR 583.20 - Savings and loan holding company.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 6 2014-01-01 2012-01-01 true Savings and loan holding company. 583.20 Section... REGULATIONS AFFECTING SAVINGS AND LOAN HOLDING COMPANIES § 583.20 Savings and loan holding company. The term savings and loan holding company means any company that directly or indirectly controls a...