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Sample records for adams county rocky

  1. Rocky Mountain Arsenal NPDES Permit

    EPA Pesticide Factsheets

    Under NPDES permit CO-0035009, the U.S. Department of Interior's Fish and Wildlife Service is authorized to discharge from the Rocky Mountain Arsenal recycled water pipeline to Lower Derby Lake in Adams County, Colo.

  2. Vegetation Resources of Rocky Mountain Arsenal, Adams County, Colorado

    DTIC Science & Technology

    1989-10-01

    Astragalus missouriensis Missouri Milkvetch PF N Gledltsia triacanthos: Honey Locust T I Glycyrrhiza lepidota Wild Licorice ITF N Lupinus argenteus...Compositae Euthamia occidentali~s Western Goldenrod Cornpositae Glycyrrhiza lepidota Wild Licorice Legtiminosae Hippochaete laevigata Scouring Rush...Convolvulaceae E.rysinum cheiranthoides Little Wallflower Cruciferae Euphorbia cyparissias Spurge Euphorbiaceae Glycyrrhiza lepidota Wild Licorice Leguminosae

  3. Wildlife Resources of the Rocky Mountain Arsenal, Adams County, Colorado

    DTIC Science & Technology

    1989-08-01

    18 3.4 PRAIRIE DOGS .................................. 18 3.5 SMALL MAMMALS ........................... 21 3.6 OTHER MAMMALS...50 4.4 PRAIRIE DOGS ................................... 53 4.5 SMALL MAMMALS .................................. 58 -1- I I I I TABLE OF...INFORMATION Accen’tzn For ’i t5 -ii L_, * LIST OF TABLES Table Page 1 4-1 Percent of young prairie dogs ....................... 54 4-2 Relative abundance of

  4. Aquatic Resources of Rocky Mountain Arsenal Adams County, Colorado

    DTIC Science & Technology

    1989-09-01

    Platyhelminthes3Turbellaria sp. D D,P D Nematoda sp. D,P** D,P D,P Annelida Hi rundinea Eropobdellidae sp. D,P Gloss iphoni idae Helobdella sp. P D D,P Helobdella stagnalis...D. G. Cook. 1974. Aquatic earthworms ( Annelida ; Cligochaeta). In: Hart, C. W., Jr. and S. L. H. Fuller (Eds.). Pollution e-cology of freshwater...Lakes. August 14, 1953. Klemm, D. J. 1985. A guide to the freshwater Annelida (Polychaeta, Naidid, and Tubificid Oligochaeta, and Hirudinea) of North

  5. 3. FIRSTFLOOR LABORATORY. VIEW TO SOUTHWEST. Rocky Mountain Arsenal, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. FIRST-FLOOR LABORATORY. VIEW TO SOUTHWEST. - Rocky Mountain Arsenal, Administration-Laboratory- Change House-Bomb Rail, 420 feet South of December Seventh Avenue; 530 feet West of D Street, Commerce City, Adams County, CO

  6. 7. INTERIOR OF BUILDING 514. VIEW TO WEST. Rocky ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. INTERIOR OF BUILDING 514. VIEW TO WEST. - Rocky Mountain Arsenal, Lewisite Reactor & Distilled Mustard Distillation Building, 420 feet South of December Seventh Avenue; 1070 feet East of D Street, Commerce City, Adams County, CO

  7. 8. INTERIOR OF BUILDING 514. VIEW TO EAST. Rocky ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. INTERIOR OF BUILDING 514. VIEW TO EAST. - Rocky Mountain Arsenal, Lewisite Reactor & Distilled Mustard Distillation Building, 420 feet South of December Seventh Avenue; 1070 feet East of D Street, Commerce City, Adams County, CO

  8. 9. INTERIOR OF BUILDING 514. VIEW TO WEST. Rocky ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. INTERIOR OF BUILDING 514. VIEW TO WEST. - Rocky Mountain Arsenal, Lewisite Reactor & Distilled Mustard Distillation Building, 420 feet South of December Seventh Avenue; 1070 feet East of D Street, Commerce City, Adams County, CO

  9. 1. SUBMERGED QUENCH INCINERATOR. VIEW TO SOUTHEAST. Rocky Mountain ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. SUBMERGED QUENCH INCINERATOR. VIEW TO SOUTHEAST. - Rocky Mountain Arsenal, Submerged Quench Incinerator, 3940 feet South of Ninth Avenue; 930 feet West of Road NS-4, Commerce City, Adams County, CO

  10. 2. INTERIOR OF BUILDING 1602. VIEW TO WEST. Rocky ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. INTERIOR OF BUILDING 1602. VIEW TO WEST. - Rocky Mountain Arsenal, Ammunition Demolition Building-Paint Storage, 40 feet North of Road EW-2; 2900 feet East of D Street, Commerce City, Adams County, CO

  11. 18. INTERIOR OF BUILDING 1606. VIEW TO SOUTH. Rocky ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    18. INTERIOR OF BUILDING 1606. VIEW TO SOUTH. - Rocky Mountain Arsenal, Cluster Bomb Assembly-Filling-Storage Building, 3500 feet South of Ninth Avenue; 2870 feet East of D Street, Commerce City, Adams County, CO

  12. 7. INTERIOR OF BUILDING 1601. VIEW TO SOUTH. Rocky ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. INTERIOR OF BUILDING 1601. VIEW TO SOUTH. - Rocky Mountain Arsenal, Cluster Bomb Assembly-Filling-Storage Building, 3500 feet South of Ninth Avenue; 2870 feet East of D Street, Commerce City, Adams County, CO

  13. 10. INTERIOR OF BUILDING 1606. VIEW TO SOUTH. Rocky ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. INTERIOR OF BUILDING 1606. VIEW TO SOUTH. - Rocky Mountain Arsenal, Cluster Bomb Assembly-Filling-Storage Building, 3500 feet South of Ninth Avenue; 2870 feet East of D Street, Commerce City, Adams County, CO

  14. 9. INTERIOR OF BUILDING 1601. VIEW TO SOUTH. Rocky ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. INTERIOR OF BUILDING 1601. VIEW TO SOUTH. - Rocky Mountain Arsenal, Cluster Bomb Assembly-Filling-Storage Building, 3500 feet South of Ninth Avenue; 2870 feet East of D Street, Commerce City, Adams County, CO

  15. 22. INTERIOR OF BUILDING 1606. VIEW TO NORTH. Rocky ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    22. INTERIOR OF BUILDING 1606. VIEW TO NORTH. - Rocky Mountain Arsenal, Cluster Bomb Assembly-Filling-Storage Building, 3500 feet South of Ninth Avenue; 2870 feet East of D Street, Commerce City, Adams County, CO

  16. 6. INTERIOR OF BUILDING 1601. VIEW TO SOUTHEAST. Rocky ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. INTERIOR OF BUILDING 1601. VIEW TO SOUTHEAST. - Rocky Mountain Arsenal, Cluster Bomb Assembly-Filling-Storage Building, 3500 feet South of Ninth Avenue; 2870 feet East of D Street, Commerce City, Adams County, CO

  17. 19. INTERIOR OF BUILDING 1606. VIEW TO SOUTH. Rocky ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    19. INTERIOR OF BUILDING 1606. VIEW TO SOUTH. - Rocky Mountain Arsenal, Cluster Bomb Assembly-Filling-Storage Building, 3500 feet South of Ninth Avenue; 2870 feet East of D Street, Commerce City, Adams County, CO

  18. 13. INTERIOR OF BUILDING 1606. VIEW TO WEST. Rocky ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. INTERIOR OF BUILDING 1606. VIEW TO WEST. - Rocky Mountain Arsenal, Cluster Bomb Assembly-Filling-Storage Building, 3500 feet South of Ninth Avenue; 2870 feet East of D Street, Commerce City, Adams County, CO

  19. 11. INTERIOR OF BUILDING 1606. VIEW TO WEST. Rocky ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. INTERIOR OF BUILDING 1606. VIEW TO WEST. - Rocky Mountain Arsenal, Cluster Bomb Assembly-Filling-Storage Building, 3500 feet South of Ninth Avenue; 2870 feet East of D Street, Commerce City, Adams County, CO

  20. 23. INTERIOR OF BUILDING 1607. VIEW TO NORTH. Rocky ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    23. INTERIOR OF BUILDING 1607. VIEW TO NORTH. - Rocky Mountain Arsenal, Cluster Bomb Assembly-Filling-Storage Building, 3500 feet South of Ninth Avenue; 2870 feet East of D Street, Commerce City, Adams County, CO

  1. 8. INTERIOR OF BUILDING 1601. VIEW TO NORTH. Rocky ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. INTERIOR OF BUILDING 1601. VIEW TO NORTH. - Rocky Mountain Arsenal, Cluster Bomb Assembly-Filling-Storage Building, 3500 feet South of Ninth Avenue; 2870 feet East of D Street, Commerce City, Adams County, CO

  2. 20. INTERIOR OF BUILDING 1606. VIEW TO SOUTH. Rocky ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    20. INTERIOR OF BUILDING 1606. VIEW TO SOUTH. - Rocky Mountain Arsenal, Cluster Bomb Assembly-Filling-Storage Building, 3500 feet South of Ninth Avenue; 2870 feet East of D Street, Commerce City, Adams County, CO

  3. 1. BUILDING 411A. VIEW TO NORTHEAST. Rocky Mountain Arsenal, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. BUILDING 411A. VIEW TO NORTHEAST. - Rocky Mountain Arsenal, Sulfur Monochloride & Dichloride Manufacturing, 1003 feet South of December Seventh Avenue; 412 feet East of D Street, Commerce City, Adams County, CO

  4. 4. FIRSTFLOOR SHOWER/LOCKER ROOM. VIEW TO NORTHEAST. Rocky Mountain ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. FIRST-FLOOR SHOWER/LOCKER ROOM. VIEW TO NORTHEAST. - Rocky Mountain Arsenal, Administration-Laboratory- Change House-Bomb Rail, 420 feet South of December Seventh Avenue; 530 feet West of D Street, Commerce City, Adams County, CO

  5. 4. BUILDING 741/742. VIEW TO NORTHWEST. Rocky Mountain Arsenal, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. BUILDING 741/742. VIEW TO NORTHWEST. - Rocky Mountain Arsenal, Refrigeration Napalm & Incendiary Bomb Warehouse-Bomb Filling, 825 feet South of December Seventh Avenue; 2425 feet East of D Street, Commerce City, Adams County, CO

  6. 6. BUILDING 741/742. VIEW TO SOUTHEAST. Rocky Mountain Arsenal, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. BUILDING 741/742. VIEW TO SOUTHEAST. - Rocky Mountain Arsenal, Refrigeration Napalm & Incendiary Bomb Warehouse-Bomb Filling, 825 feet South of December Seventh Avenue; 2425 feet East of D Street, Commerce City, Adams County, CO

  7. 3. BUILDING 741/742. VIEW TO WEST. Rocky Mountain Arsenal, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. BUILDING 741/742. VIEW TO WEST. - Rocky Mountain Arsenal, Refrigeration Napalm & Incendiary Bomb Warehouse-Bomb Filling, 825 feet South of December Seventh Avenue; 2425 feet East of D Street, Commerce City, Adams County, CO

  8. 2. BUILDING 741/742. VIEW TO SOUTHWEST. Rocky Mountain Arsenal, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. BUILDING 741/742. VIEW TO SOUTHWEST. - Rocky Mountain Arsenal, Refrigeration Napalm & Incendiary Bomb Warehouse-Bomb Filling, 825 feet South of December Seventh Avenue; 2425 feet East of D Street, Commerce City, Adams County, CO

  9. 5. BUILDING 741/742. VIEW TO NORTHEAST. Rocky Mountain Arsenal, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. BUILDING 741/742. VIEW TO NORTHEAST. - Rocky Mountain Arsenal, Refrigeration Napalm & Incendiary Bomb Warehouse-Bomb Filling, 825 feet South of December Seventh Avenue; 2425 feet East of D Street, Commerce City, Adams County, CO

  10. 1. BUILDING 741/742. VIEW TO SOUTH. Rocky Mountain Arsenal, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. BUILDING 741/742. VIEW TO SOUTH. - Rocky Mountain Arsenal, Refrigeration Napalm & Incendiary Bomb Warehouse-Bomb Filling, 825 feet South of December Seventh Avenue; 2425 feet East of D Street, Commerce City, Adams County, CO

  11. 77 FR 2992 - Columbia National Wildlife Refuge, Adams and Grant Counties, WA; Final Comprehensive Conservation...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-20

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE INTERIOR Fish and Wildlife Service Columbia National Wildlife Refuge, Adams and Grant Counties, WA; Final Comprehensive Conservation Plan and Finding of No Significant Impact for Environmental Assessment AGENCY:...

  12. Geochemical survey of the Adams Gap and Shinbone Creek Roadless Areas, Clay County, Alabama

    USGS Publications Warehouse

    Robinson, G.R.; Klein, T.L.; Lesure, F.G.; Hanley, J.T.

    1984-01-01

    Reports covering the mineral resources of Clay County and vicinity include Brewer (1896) and Adams (1930) on gold, Prouty (1923) on graphite, and Heinrich and Olson (1953) on mica. The mineral resources of the Talladega National Forest were evaluated by Gilbert and Smith (1973). The mineral resource potential of the two roadless areas is detailed in Robinson and others (1983) and an accompanying geologic report is given in Robinson and others (in press).

  13. An Archeological Overview and Management Plan for the Rocky Mountain Arsenal, Adams County, Colorado

    DTIC Science & Technology

    1984-05-14

    a set of railroad tracks, chemical munitions production and fill plants, stor- age vaults , scrubbers and decontamination buildings, fuse detonation...Ethnohistoric period cultural resources are important be- cause these materials represent a time of significant subsistence change (pedestrian to equestrian

  14. Analyses of geochemical samples and descriptions of rock samples, Adams Gap and Shinbone Creek Roadless Areas, Clay County, Alabama

    USGS Publications Warehouse

    Erickson, M.S.; Hanley, J.T.; Kelley, D.L.; Sherlock, L.J.

    1983-01-01

    Semiquantitative spectrographic analyses for 31 elements on 105 rocks, 47 stream-sediment, and 70 soil samples from the Adams Gap and Shinbone Creek Roadless Areas and vicinity, Talladega National Forest, Clay County, Alabama are reported here in detail. Atomic-absorption analyses for zinc in all samples and for gold in 5 selected rock samples are also reported. Localities for all sables are given in Universal Transverse Mercator (UTM) coordinates. A brief description of each rock sample is included. Rocks analyzed include quartzite, phyllite, vein quartz, and schist.

  15. Superfund Record of Decision (EPA Region 5): Adams County Quincy Landfills No. 2 and 3, Quincy, IL, September 1993

    SciTech Connect

    Not Available

    1993-09-01

    This decision document serves as United States Environmental Protection Agency (USEPA) concurrence with and adoption of the remedial action decision for the Adams County Quincy Landfills 2 3 site. The remedial action addresses two areas of concern--leachate and groundwater. The leachate remedial action addresses the source of the contamination by collecting and treating on-site waste. The function of this action is to control the landfill site as a source of groundwater contamination, to reduce the risks associated with exposure to contaminated materials, and to prevent untreated leachate from running off site. The groundwater remedial action involves long-term monitoring with cleanup levels.

  16. Shapefile of the Elevation of the Bedrock Surface Beneath the Rocky Flats Alluvial Fan, Boulder and Jefferson Counties, Colorado

    USGS Publications Warehouse

    Knepper, Daniel H.

    2003-01-01

    The Rocky Flats alluvial fan is a large early Pleistocene gravel deposit at the mouth of Coal Creek Canyon along the eastern flank of the Colorado Front Range in Jefferson and Boulder Counties, Colorado. Elevations of the bedrock surface beneath the alluvial fan gravels have been compiled at selected points from a variety of sources and recorded in a digital dataset suitable for importing into commonly used GIS and image processing software packages.

  17. Superfund Record of Decision (EPA Region 8): Broderick Wood Products, Adams County, CO. (First remedial action), (Amendment), September 1991

    SciTech Connect

    Not Available

    1991-09-24

    The 64-acre Broderick Wood Products (BWP) site is a former wood treatment facility in Adams County, Colorado. Land use in the area is predominantly industrial. The site is one-half mile south of Clear Creek, a perennial stream. In 1981 and 1982, EPA noted several violations of RCRA requirements. A future ROD will address the final remedy for the site by providing treatment of contaminated soil, debris, and surface and ground water. The primary contaminants of concern affecting the sludge are VOCs including toluene and xylenes; other organics including dioxin and PAHs; and metals including lead. The amended remedial action for the site includes excavating and preparing 950 cubic yards of solid sludge, 1,220 cubic yards of liquid sludge, and 500 gallons of oil collected from the sludge from temporary storage cells within the impoundments area; and transporting sludge and oil to a permitted recycling facility to reclaim creosote for use.

  18. Summary of hydrogeologic and ground-water-quality data and hydrogeologic framework at selected well sites, Adams County, Pennsylvania

    USGS Publications Warehouse

    Low, Dennis J.; Dugas, Diana L.

    1999-01-01

    Rapid population growth in Adams County has increased the demand for ground water and led Adams County planning officials to undertake an effort to evaluate the capabilities of existing community water systems to meet future, projected growth and to begin wellhead-protection programs for public-supply wells. As part of this effort, this report summarizes ground-water data on a countywide scale and provides hydrogeologic information needed to delineate wellheadprotection areas in three hydrogeologic units (Gettysburg Lowland, Blue Ridge, and Piedmont Lowland). Reported yields, specific capacities, well depths, and reported overburden thickness can vary by hydrogeologic unit, geologic formation, water use (domestic and nondomestic), and topographic setting. The reported yields of domestic wells drilled in the Gettysburg Lowland (median reported yield of 10 gallons per minute) are significantly greater than the reported yields from the Blue Ridge, Piedmont Lowland, and Piedmont Upland (median reported yields of 7.0, 8.0, and 7.0 gallons per minute, respectively). Reported yields of domestic wells completed in the diabase and the New Oxford Formation of the Gettysburg Lowland, and in the metarhyolite and metabasalt of the Blue Ridge, are significantly lower than reported yields of wells completed in the Gettysburg Formation. For nondomestic wells, reported yields from the Conestoga Formation of the Piedmont Lowland are significantly greater than in the diabase. Reported yields of nondomestic wells drilled in the Gettysburg, New Oxford, and Conestoga Formations, and the metarhyolite are significantly greater than those for domestic wells drilled in the respective geologic formations. Specific capacities of nondomestic wells in the Conestoga and Gettysburg Formations are significantly greater than their domestic counterparts. Specific capacities of nondomestic wells in the Conestoga Formation are significantly greater than the specific capacities of nondomestic wells in

  19. Mineral Resources of the Hells Canyon Study Area, Wallowa County, Oregon, and Idaho and Adams Counties, Idaho

    USGS Publications Warehouse

    Simmons, George C.; Gualtieri, James L.; Close, Terry J.; Federspiel, Francis E.; Leszcykowski, Andrew M.

    2007-01-01

    Field studies supporting the evaluation of the mineral potential of the Hells Canyon study area were carried out by the U.S. Geological Survey and the U.S. Bureau of Mines in 1974-76 and 1979. The study area includes (1) the Hells Canyon Wilderness; (2) parts of the Snake River, Rapid River, and West Fork Rapid River Wild and Scenic Rivers; (3) lands included in the second Roadless Area Review and Evaluation (RARE II); and (4) part of the Hells Canyon National Recreation Area. The survey is one of a series of studies to appraise the suitability of the area for inclusion in the National Wilderness Preservation System as required by the Wilderness Act of 1964. The spectacular and mineralized area covers nearly 950 mi2 (2,460 km2) in northeast Oregon and west-central Idaho at the junction of the Northern Rocky Mountains and the Columbia Plateau.

  20. Example evaluation of a permit application for a proposed hazardous-waste landfill in eastern Adams County, Colorado

    USGS Publications Warehouse

    Banta, E.R.

    1986-01-01

    A project was undertaken by the U.S. Geological Survey in cooperation with the U. S. Environmental Protection Agency to demonstrate methods by which RCRA (Resources Conservation and Recovery Act of 1976) Part B permit applications might be evaluated. The purpose of the project was to prepare a report that would supplement a series of case studies to be made available to permit writers in the U.S. Environmental Protection Agency. Four sites in the United States were chosen for their potential applicability to geologically similar sites. The Adams County, Colorado, site was chosen to be representative of sites in the Upper Cretaceous Pierre Shale. The intent of this report is to provide an example of how available earth-science information might be used in evaluating an application and not to evaluate the acceptability of the site. Because this study is an evaluation of a permit application, the data used are limited to the data supplied in the application and in published reports. Of the five criteria required by the U.S. Environmental Protection Agency to be addressed in the permit application considered in the case study, the application was evaluated to be inadequate in addressing three criteria: (1) Site characterization, (2) ability to monitor the location, and (3) flow paths and 100-foot time of travel. Details of the inadequacies and a description of the information needed to eliminate the inadequacies are included in the report. (USGS)

  1. 77 FR 64847 - Union Pacific Railroad Company-Abandonment Exemption-in Adams, Weld and Boulder Counties, Colo.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-23

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF TRANSPORTATION Surface Transportation Board Union Pacific Railroad Company--Abandonment Exemption--in Adams, Weld... near Eastlake to the end of the line at milepost 33.17 near Valmont, in Adams, Weld and...

  2. Distribution of corticolous noncrustose lichens on trunks of Rocky Mountain junipers in Boulder County, Colorado.

    USGS Publications Warehouse

    Peard, J.L.

    1983-01-01

    Nineteen species of noncrustose lichens were found on Juniperus scopulorum bark; 3 species had relatively high cover and frequency values and were characterized as typical lichens of Rocky Mountain junipers: Xanthoria fallax, Phaeophyscia hirsuta and Physcia caesia. Total cover per tree was low (4%) and most species preferred the N and E sides of trunk bases. These distributional trends may reflect gradients of exposure to wind, insolation, and rate of bark exfoliation. -Author Juniperus scopulorum Phaeophyscia hirsuta Physcia caesia Xanthoria fallax.

  3. Vascular flora of the Rocky Flats area, Jefferson County, Colorado, USA

    DOE PAGES

    Nelson, Jody K.

    2010-08-01

    The Rocky Flats Site (Site) is a U.S. Department of Energy (DOE) facility near Golden, Colorado that produced nuclear weapons components during the Cold War. Like many federal properties that have been off-limits to public access for decades, it has become a refugia for biodiversity as surrounding landscapes have been lost to agriculture and urbanization. A floristic study of the area was conducted on approximately 2,505 ha (6,189 ac) and includes the parcels currently managed and operated by DOE and the U.S. Fish and Wildlife Service (Rocky Flats National Wildlife Refuge). A flora of 630 species of vascular plants inmore » 84 families and 340 genera was documented, including 12 species endemic to the southern Rocky Mountains and seven species considered rare or imperiled by the Colorado Natural Heritage Program. The flora of the Site is characterized by a predominantly Western North American floristic element, however, an Adventive floristic element contributes the greatest number of species. The vegetation is dominated by xeric tallgrass prairie and mixed grass prairie, with areas of wetland, shrubland, and riparian woodland.« less

  4. Vascular flora of the Rocky Flats area, Jefferson County, Colorado, USA

    SciTech Connect

    Nelson, Jody K.

    2010-08-01

    The Rocky Flats Site (Site) is a U.S. Department of Energy (DOE) facility near Golden, Colorado that produced nuclear weapons components during the Cold War. Like many federal properties that have been off-limits to public access for decades, it has become a refugia for biodiversity as surrounding landscapes have been lost to agriculture and urbanization. A floristic study of the area was conducted on approximately 2,505 ha (6,189 ac) and includes the parcels currently managed and operated by DOE and the U.S. Fish and Wildlife Service (Rocky Flats National Wildlife Refuge). A flora of 630 species of vascular plants in 84 families and 340 genera was documented, including 12 species endemic to the southern Rocky Mountains and seven species considered rare or imperiled by the Colorado Natural Heritage Program. The flora of the Site is characterized by a predominantly Western North American floristic element, however, an Adventive floristic element contributes the greatest number of species. The vegetation is dominated by xeric tallgrass prairie and mixed grass prairie, with areas of wetland, shrubland, and riparian woodland.

  5. Hydrology of a nuclear-processing plant site, Rocky Flats, Jefferson County, Colorado

    USGS Publications Warehouse

    Hurr, R. Theodore

    1976-01-01

    Accidental releases of contaminants resulting from the operation of the U.S. Energy Research and Development Administration's nuclear-processing and recovery plant located on Rocky Flats will move at different rates through -different parts of the hydrologic system. Rates of movement are dependent upon the magnitude of the accidental release and the hydrologic conditions at the time of the release. For example, during wet periods, a contaminant resulting from a 5,000-gallon (19,000-1itre) release on the land surface would enter the ground-water system in about 2 to 12 hours. Ground-water flow in the Rocky Flats Alluvium might move the contaminant eastward at a rate of about 3 to 11 feet (0.9 to 3.4 metres) per day, if it remains dissolved. Maximum time to a point of discharge would be about 3 years; minimum time could be a few days. A contaminant entering a stream would then move at a rate of about 60 feet (18 metres) per minute under pool-and-riffle conditions. The rate of movement might be about 420 feet (128 metres) per minute under open-channel-flow conditions following intense thunderstorms.

  6. Superfund Record of Decision (EPA Region 8): Broderick Wood Products, Operable Unit 2, Adams County, Co. (Second remedial action), March 1992. Final report

    SciTech Connect

    Not Available

    1992-03-24

    The 64-acre Broderick Wood Products (BWP) site is a former wood preserving facility in unincorporated Adams County, Colorado, located just outside of Denver, Colorado. Land use in the area is predominantly industrial. There are three aquifers below the site. Approximately 70 drums containing various chemicals, oils, and asbestos are stored in the process area, and 65 drums of oil from sludge are stored in the impoundment area of the site. The ROD addresses OU2, a final remedy for the BWP site. The primary contaminants of concern affecting the soil, debris, sediment, and ground water are VOCs, including benzene, toluene, and xylenes; organics, including PAHs, dioxins, furans, and PCP and other phenolic compounds; and metals, including arsenic and lead. The selected remedial action for the site includes treatment of the debris, soil and sediments, and ground water.

  7. Superfund Record of Decision (EPA region 3): Keystone Sanitation Landfill site, Adams County, Union Township, PA. (First remedial action), September 1990

    SciTech Connect

    Not Available

    1990-09-30

    The 40-acre Keystone Sanitation Landfill site, an inactive, privately owned landfill, is in Union Township, Adams County, Pennsylvania. Surrounding land use is primarily agricultural with scattered residences. From 1966 to 1990, the unlined landfill accepted household and municipal wastes as well as industrial and construction debris, including phosphorus-contaminated sand, potato sludge, resin sludge, incineration ash, and dried latex paint. In 1982, State investigations revealed onsite ground water contamination and a contaminated onsite residential well. In 1984, EPA found low-level contamination in nearby residential wells. The Record of Decision (ROD) addresses Operable Unit 1, the containment of onsite source area and remediation of onsite contaminated ground water. A subsequent ROD will address offsite ground water contamination in monitoring and residential wells. The primary contaminants of concern affecting the soil and ground water are VOCs including benzene, PCE, TCE, vinyl chloride; other organics including acids, and phenols; and metals including chromium and lead.

  8. Bedrock erosion surface beneath the rocky flats alluvial fan, Jefferson and Boulder counties, Colorado

    USGS Publications Warehouse

    Knepper, D.H.

    2005-01-01

    The early Pleistocene Rocky Flats alluvial fan formed at the mouth of unglaciated Coal Creek Canyon along the eastern flank of the Colorado Front Range. The fan consists of boulder, cobble, and pebble gravel deposited on an erosional surface cut on tilted Mesozoic sedimentary strata. A north-trending hogback of steeply dipping Cretaceous Laramie Formation and Fox Hills Sandstone is exposed through the gravel across the central portion of the fan. Elevations on the gravel-bedrock contact were used in a GIS to reconstruct the bedrock surface at the base of the gravel, providing a glimpse of the geomorphology of the early Pleistocene Colorado Piedmont. The reconstructed erosional bedrock surface portrays a landscape carved by a series of easterly flowing streams that eroded headward to the resistant hogback units, creating a bedrock step up to 37 m high. East-trending ridges on the bedrock surface are remnants of drainage divides between the Pleistocene streams. Water gaps in the bedrock step allowed the streams access to the upper surface of the step. This entire surface, except the hogback, was covered by gravel about 1.35 to 1.5 Ma ago. Subsequent erosion of the alluvial fan has been by headward (westward) erosion of easterly flowing streams incising into the eastern portion of the fan. Because the gravel is more resistant than the underlying bedrock, modern streams are established over the Pleistocene drainage divides, where the gravel was thinnest. Thicker gravel in the Pleistocene paleovalleys now caps modern drainage divides, producing an inverted topography.

  9. Ground-water resources of the South Platte River Basin in western Adams and southwestern Weld Counties, Colorado

    USGS Publications Warehouse

    Smith, Rex O.; Schneider, P.A.; Petri, Lester R.

    1964-01-01

    The area described in this report consists of about 970 square miles in western Adams and southwestern Weld Counties in northeastern Colorado. It includes that part of the South Platte River valley between Denver and Kuner, Colo., all of Beebe Draw, and the lower part of the valley of Box Elder Creek. The stream-valley lowlands are separated by rolling uplands. The climate is semiarid, the normal annual precipitation being about 13 inches; thus, irrigation is essential for stable agricultural development. The area contains about 220,000 acres of irrigated land in the stream valleys. Most of the remaining 400,000 acres of land is used for dry farming or grazing because it lacks irrigation water. Most of the lowlands were brought under irrigation with surface water during the early 1900's, and now nearly all the surface water in the area is appropriated for irrigation within and downstream from the area. Because the natural flow of the streams is sometimes less than the demand for water, ground water is used to supplement the surface-water supply. Wells, drilled chiefly since 1930, supply the supplemental water and in some places are the sole supply for irrigation use. Rocks exposed in the area are of sedimentary origin and range in age from Lato Cretaceous to Recent. Those that are consolidated, called 'bedrock' in this report, consist of the Fox Hills sandstone and the Laramie and Arapahoe formations, all of Late Cretaceous age, and the Denver formation and Dawson arkose of Late Cretaceous and Tertiary age. The surface of the bedrock was shaped by ancestral streams, the valleys of which are reflected by the present surface topography. Dune sand, slope wash, and thin upland deposits of Quaternary age mantle the bedrock in the divide areas, and stream deposits ranging in thickness from 0 to about 125 feet partly fill the ancestral valleys. The valley-fill deposits consist of beds and lenses of clay, silt, sand, gravel, cobbles, and boulders. Abundant supplies of

  10. 75 FR 51519 - Regional Transportation District-Acquisition Exemption-Union Pacific Railroad Company in Adams...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-20

    ... Railroad Company in Adams, Denver, and Jefferson Counties, CO Regional Transportation District (RTD) \\1... Subdivision extending approximately 8.96 miles, from milepost 628.50, in Adams County, CO., to milepost...

  11. Conceptual Model of Hydrologic and Thermal Conditions of the Eastbank Aquifer System near Rocky Reach Dam, Douglas County, Washington

    USGS Publications Warehouse

    van Heeswijk, Marijke; Cox, Stephen E.; Huffman, Raegan L.; Curran, Christopher A.

    2008-01-01

    The Lower and Combined Aquifers of the Eastbank Aquifer system, located in a river-terrace deposit along the Columbia River near Rocky Reach Dam, Washington, are primarily recharged by the Columbia River and provide water to the Eastbank Hatchery and the regional water system servicing the cities of Wenatchee, East Wenatchee, and parts of unincorporated Chelan and Douglas Counties. In 2006, mean annual pumpage from the aquifers by the hatchery and regional water system was about 43 and 16 cubic feet per second, respectively. Reportedly, temperatures of ground water pumped by the hatchery have been increasing, thereby making water potentially too warm for salmonid fish production. An evaluation of hourly ground-water and river temperatures from January 1991 through August 2007 indicates increasing interannual trends in temperatures in most of the Lower and Combined Aquifers from 1999 through 2006 that correspond to increasing trends in the annual mean and annual maximum river temperatures during the same period of 0.07 and 0.17?C per year, respectively. There were no trends in the annual minimum river temperatures from 1999 through 2006, and there were no trends in the annual minimum, mean, and maximum river temperatures from 1991 through 1998 and from 1991 through 2007. Increases in river temperatures from 1999 through 2006 are within the natural variability of the river temperatures. Most of the Lower and Combined Aquifers reached thermal equilibrium?defined by constant time lags between changes in river temperatures and subsequent changes in ground-water temperatures?during 1991?98. The only exceptions are the Combined Aquifer north of the well field of the regional water system, which had not reached thermal equilibrium by 2006, and the Lower Aquifer west of the well fields of the hatchery and the regional water system, which reached thermal equilibrium prior to 1991. Because most of the Lower and Combined Aquifers were in thermal equilibrium from 1999 through

  12. Remedy risk evaluation for the shell section 36 trench area of the Rocky Mountain Arsenal

    SciTech Connect

    1993-08-01

    The Rocky Mountain Arsenal (RMA) is a 17,000-acre U.S. Army facility located in Adams County, Colorado. Liquid and solid wastes produced by Shell operations in the South Plants area were disposed of in an on-post section of the RMA known as the Shell Section 36 Trench (Shell Trench) Area. While there is considerable uncertainty regarding the composition of these wastes, historical process records and environmental sampling results indicate the presence of a heterogeneous mixture of chemicals consisting primarily of organochlorine pesticides and volatile organic compounds. The Army may have also used this area of the RMA for the disposal of munitions and chemical agents.

  13. John Adams' essential tremor.

    PubMed

    Louis, Elan D; Kavanagh, Patricia

    2005-12-01

    John Adams (1735-1826), one of the signers of the Declaration of Independence, was the second President of the United States. Adams had tremor for many years, about which little has been written. We examined John Adams' penmanship over a 62-year period and studied his correspondence and diaries. It is not clear when Adams' tremor began, although in a diary entry dated 6 December 1760, when Adams was 25 years old, there is evidence of low-amplitude kinetic tremor. The tremor continued in his written correspondence, becoming more persistent over time. Later in life, the clarity of his written correspondence diminished, with greater decomposition of characters and a reduction in the size of individual characters. This finding raises some speculation as to whether Adams could have been developing some parkinsonism, although the evidence in favor of this is not compelling. The most likely diagnosis was essential tremor.

  14. The ADAMS interactive interpreter

    SciTech Connect

    Rietscha, E.R.

    1990-12-17

    The ADAMS (Advanced DAta Management System) project is exploring next generation database technology. Database management does not follow the usual programming paradigm. Instead, the database dictionary provides an additional name space environment that should be interactively created and tested before writing application code. This document describes the implementation and operation of the ADAMS Interpreter, an interactive interface to the ADAMS data dictionary and runtime system. The Interpreter executes individual statements of the ADAMS Interface Language, providing a fast, interactive mechanism to define and access persistent databases. 5 refs.

  15. Removal of n-nitrosodimethylamine from Rocky Mountain Arsenal waters using innovative adsorption technologies. Final report

    SciTech Connect

    Fleming, E.C.; Pennington, J.C.; Francingues, N.R.; Felt, D.R.; Wachob, B.G.

    1996-08-01

    The Rocky Mountain Arsenal (RMA) occupies 27 square miles in Adams County, Colorado, and is located adjacent to the Stapleton Airport. Figure 1 illustrates a general map of the RMA. The U.S. Department of the Army established the RMA in 1942 for the purpose of producing chemicals such as napalm, mustard agent, lewisite, and chlorine. After World War II, a number of private organizations leased the arsenal from the Army for a variety of manufacturing purposes. Most of the manufacturing activities were conducted in the South Plants area (see Figure 1). The North Plants were constructed in 1951 for GB nerve agent production, munitions filling, and demilitarization of munitions and used until 1957. During the 1950s and 1960s, the Air Force operated the hydrazine blending and storage facility (HBSF) of symmetrical and unsymmetrical dimethyl hydrazine (UDMH). The hydrazine produced at the HBSF was used for the Titan Missile and Lunar Lander programs.

  16. Analytical results and sample locality map of stream-sediment, heavy-mineral-concentrate, and rock samples from the Little Rockies, Mount Pennell, and Mount Hillers Wilderness Study Areas (UT-050-247,248,249), Garfield County, Utah

    SciTech Connect

    Detra, D.E.; Erickson, M.S.; Kemp, W.M. III; Willson, W.R.

    1984-01-01

    This report presents the results of a geochemical and mineralogical survey of the Little Rockies, Mount Pennell, and Mount Hillers Wilderness Study Areas (UT-050-247,248,249), Garfield County, Utah. The Little Rockies, Mount Pennell, and Mount Hillers Wilderness Study Areas comprise about 350 mi/sup 2/ (910 km/sup 2/) in Garfield County, Utah. The study areas occupy the southern portion of the Henry Mountains and includes Mount Pennell, Mount Hillers, and Mount Ellsworth. The areas consist of a series of diorite porphyry laccoliths and their satellite bodies, all of Eocene age, which intrude the 8000 ft (2500 m) thick Henry Basin sediments which range in age from Permian to Holocene. Only Triassic and younger rocks are exposed in the areas. Samples were collected at 153 sites. At nearly all of those sites, both a stream-sediment sample and a heavy-mineral-concentrate sample were collected. Where suitable outcrop was available, rock samples were collected. In addition to the spectrographic analysis all heavy-mineral-concentrate samples were mineralogically analyzed. Minerals reported include zircon (round and euhedral), sphene, rutile, anatase, barite, apatite, scheelite, epidote, pyrite, pyroxene, arsenopyrite, amphibole, and rock fragments.

  17. 75 FR 76953 - Foreign-Trade Zone 214-Lenoir County, North Carolina Site Renumbering Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-10

    ... County; Site 3 (56 acres)--located at 400 English Road, Rocky Mount, Nash County; and, Site 4 (28 acres)--located at 1201 Thorpe Road, Rocky Mount, Nash County. For further information, contact Maureen Hinman...

  18. ADAM function in embryogenesis

    PubMed Central

    Alfandari, Dominique; McCusker, Catherine; Cousin, Hélène

    2009-01-01

    Cleavage of proteins inserted into the plasma membrane (shedding) is an essential process controlling many biological functions including cell signaling, cell adhesion and migration as well as proliferation and differentiation. ADAM surface metalloproteases have been shown to play an essential role in these processes. Gene inactivation during embryonic development have provided evidence of the central role of ADAM proteins in nematodes, flies, frogs, birds and mammals. The relative contribution of four subfamilies of ADAM proteins to developmental processes is the focus of this review. PMID:18935966

  19. 76 FR 21425 - Rocky Mountain Railcar and Repair, Inc.-Acquisition and Operation Exemption-Line of Railroad in...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-15

    ... Surface Transportation Board Rocky Mountain Railcar and Repair, Inc.--Acquisition and Operation Exemption--Line of Railroad in Tooele County, UT Rocky Mountain Railcar and Repair, Inc. (Rocky Mountain), a... line. \\1\\ Rocky Mountain states that it currently operates a railcar repair facility, but that it...

  20. Ansel Adams: early works

    NASA Astrophysics Data System (ADS)

    Throckmorton, Jodi

    2010-02-01

    Ansel Adams (1902-1984), photographer, musician, naturalist, explorer, critic, and teacher, was a giant in the field of landscape photography. In his images of the unspoiled Western landscape, he strove to capture the sublime: the transcendentalist concept that nature can generate the experience of awe for the viewer. Many viewers are familiar with the heroic, high-contrast prints on high-gloss paper that Adams made to order beginning in the 1970s; much less well known are the intimate prints that the artist crafted earlier in his career. This exhibition focuses on these masterful small prints from the 1920s into the 1950s. During this time period, Adams's printing style changed dramatically. The painterly, soft-focus, warm-toned style of the Parmelian Prints of the High Sierras from the 1920s evolved into the sharp-focus style of the f/64 school of photography that Adams co-founded in the 1930s with Edward Weston and Imogen Cunningham. After World War II, Adams opted for a cooler, higher-contrast look for his prints. Throughout the various styles in which he chose to work, Adams explored the power of nature and succeeded in establishing landscape photography as a legitimate form of modern art.

  1. Geographic information system datasets of regolith-thickness data, regolith-thickness contours, raster-based regolith thickness, and aquifer-test and specific-capacity data for the Lost Creek Designated Ground Water Basin, Weld, Adams, and Arapahoe Counties, Colorado

    USGS Publications Warehouse

    Arnold, L. Rick

    2010-01-01

    These datasets were compiled in support of U.S. Geological Survey Scientific-Investigations Report 2010-5082-Hydrogeology and Steady-State Numerical Simulation of Groundwater Flow in the Lost Creek Designated Ground Water Basin, Weld, Adams, and Arapahoe Counties, Colorado. The datasets were developed by the U.S. Geological Survey in cooperation with the Lost Creek Ground Water Management District and the Colorado Geological Survey. The four datasets are described as follows and methods used to develop the datasets are further described in Scientific-Investigations Report 2010-5082: (1) ds507_regolith_data: This point dataset contains geologic information concerning regolith (unconsolidated sediment) thickness and top-of-bedrock altitude at selected well and test-hole locations in and near the Lost Creek Designated Ground Water Basin, Weld, Adams, and Arapahoe Counties, Colorado. Data were compiled from published reports, consultant reports, and from lithologic logs of wells and test holes on file with the U.S. Geological Survey Colorado Water Science Center and the Colorado Division of Water Resources. (2) ds507_regthick_contours: This dataset consists of contours showing generalized lines of equal regolith thickness overlying bedrock in the Lost Creek Designated Ground Water Basin, Weld, Adams, and Arapahoe Counties, Colorado. Regolith thickness was contoured manually on the basis of information provided in the dataset ds507_regolith_data. (3) ds507_regthick_grid: This dataset consists of raster-based generalized thickness of regolith overlying bedrock in the Lost Creek Designated Ground Water Basin, Weld, Adams, and Arapahoe Counties, Colorado. Regolith thickness in this dataset was derived from contours presented in the dataset ds507_regthick_contours. (4) ds507_welltest_data: This point dataset contains estimates of aquifer transmissivity and hydraulic conductivity at selected well locations in the Lost Creek Designated Ground Water Basin, Weld, Adams, and

  2. 29. AERIAL VIEW OF THE ROCKY FLATS PLANT LOOKING SOUTH. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    29. AERIAL VIEW OF THE ROCKY FLATS PLANT LOOKING SOUTH. IN 1983, THE PERIMETER SECURITY ZONE SURROUNDING THE PLUTONIUM OPERATIONS WAS COMPLETED. IT CONSISTED OF A DOUBLE PERIMETER FENCE, CLOSED CIRCUIT TELEVISIONS, ALARMS, AND AN UNINTERRUPTED POWER SUPPLY (7/29/83). - Rocky Flats Plant, Bounded by Indiana Street & Routes 93, 128 & 72, Golden, Jefferson County, CO

  3. 74. Rocky Knob Recreation area contact station. In the foreground ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    74. Rocky Knob Recreation area contact station. In the foreground is one of the Rocky Fins which is representative of the area. In the background is the contact station which opened as a gas station in September 1949. Facing northeast. - Blue Ridge Parkway, Between Shenandoah National Park & Great Smoky Mountains, Asheville, Buncombe County, NC

  4. 12. VIEW OF THE ROCKY FLATS PLANT LOOKING WEST. AFTER ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. VIEW OF THE ROCKY FLATS PLANT LOOKING WEST. AFTER 38 YEARS, WEAPONS PRODUCTION CEASED IN 1989. IN 1992, THE PLANT MISSION CHANGED FROM WEAPONS PRODUCTION TO ENVIRONMENTAL CLEAN UP AND RESTORATION. BY 1995, THE SITE HAD BEGUN TO BE DISMANTLED (6/27/95). - Rocky Flats Plant, Bounded by Indiana Street & Routes 93, 128 & 72, Golden, Jefferson County, CO

  5. 48. VIEW OF SKYLINE DRIVE FROM THE ROCKY PEAK OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    48. VIEW OF SKYLINE DRIVE FROM THE ROCKY PEAK OF STONY MAN MOUNTAIN (EL. 4,011). LOOKING NORTHEAST. STONY MAN OVERLOOK VISIBLE IN THE DISTANCE. - Skyline Drive, From Front Royal, VA to Rockfish Gap, VA , Luray, Page County, VA

  6. ADAM -- Interface Module Reference Manual

    NASA Astrophysics Data System (ADS)

    Chipperfield, A. J.; Kelly, B. D.; Wright, S. L.

    ADAM Interface Modules provide an interface between ADAM application programs and the rest of the system. This document describes in detail the facilities available with ADAM Interface Modules and the rules for using them. It is intended as a reference manual and should shed light on some of the finer points of the ADAM parameter system. Readers requiring an introduction to Interface Modules should read SG/4.

  7. Was Adam a Real Person?

    ERIC Educational Resources Information Center

    Lamoureux, Denis O.

    2011-01-01

    Belief in the historicity of Adam has been held firmly throughout the history of the church. In the light of modern biblical criticism and the evolutionary sciences, some conservative Christians are now questioning whether or not Adam was a real person. This paper argues that the existence of Adam in the opening chapters of scripture reflects an…

  8. All about Adam.

    ERIC Educational Resources Information Center

    Bradley, Ann

    1992-01-01

    Rochester Teachers Association President Adam Urbanski is kingpin of a new breed of union leaders who want to be partners, not adversaries, in the school improvement crusade. Despite his good intentions, many people in his hometown are disgruntled with him. The article describes his work over the past five years. (SM)

  9. The Adams Family

    ERIC Educational Resources Information Center

    Douven, Igor; Verbrugge, Sara

    2010-01-01

    According to Adams's Thesis, the acceptability of an indicative conditional sentence goes by the conditional probability of its consequent given its antecedent. We test, for the first time, whether this thesis is descriptively correct and show that it is not; in particular, we show that it yields the wrong predictions for people's judgments of the…

  10. Adams v. State.

    PubMed

    1998-01-01

    The Supreme Court of Georgia, on 4 May 1998, held that a state statute permitting a crime victim who is significantly exposed to HIV request an HIV blood test on the person charged with the crime and arrested does not violate the Fourth Amendment right against unreasonable searches, nor does it violate privacy or equal protection rights. Malik Adams attacked and struggled with police officers during arrest. In the struggle, Adams's and an officer's hands, on which there were bleeding wounds, came in contact. Even though Adams did not have any outward AIDS symptoms, the State filed a motion to compel HIV testing. The Supreme Court of Georgia held that, because the statute compelling HIV testing serves the compelling state interest of preventing the public's exposure to HIV, the search, in this case the taking and sampling of blood, was reasonable. The statute also did not violate Adams's right to privacy or state or federal equal protection clauses. The judgment of the Superior court was affirmed.

  11. Adams v. State.

    PubMed

    1998-01-01

    Court Decision: 498 South Eastern Reporter, 2d Series 268; 1998 May 4 (date of decision). The Supreme Court of Georgia held that a state statute permitting a crime victim who is significantly exposed to HIV request an HIV blood test on the person charged with the crime and arrested does not violate the Fourth Amendment right against unreasonable searches, nor does it violate privacy or equal protection rights. Malik Adams attacked and struggled with police officers during arrest. In the struggle, Adams's and an officer's hands, on which there were bleeding wounds, came in contact. Even though Adams did not have any outward AIDS symptoms, the State filed a motion to compel HIV testing. The Supreme Court of Georgia held that, because the statute compelling HIV testing serves the compelling state interest of preventing the public's exposure to HIV, the search, in this case the taking and sampling of blood, was reasonable. The statute also did not violate Adams's right to privacy or state or federal equal protection clauses.

  12. Rocky Mountain spotted fever

    MedlinePlus

    ... this page: //medlineplus.gov/ency/article/000654.htm Rocky Mountain spotted fever To use the sharing features on this page, please enable JavaScript. Rocky Mountain spotted fever is a disease caused by a type of ...

  13. 5. Aerial view west, Adams Dam Road bottom center, State ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Aerial view west, Adams Dam Road bottom center, State Route 100 center, duck pond and reservoir center, State Route 100 center right, State Route 92 below center right, Brandywine Creek State Park center bottom. - Winterthur Farms, Intersection State Routes 92 & 100, Intersection State Routes 92 & 100, Winterthur, New Castle County, DE

  14. 4. Aerial view southwest, Adams Dam Road bottom left, State ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Aerial view southwest, Adams Dam Road bottom left, State Route 100 center, back gates to Winterthur and Wilmington Country Club upper center, duck pond and reservoir bottom right and center, and State Route 92 center bottom. - Winterthur Farms, Intersection State Routes 92 & 100, Intersection State Routes 92 & 100, Winterthur, New Castle County, DE

  15. 3. Aerial view southeast, State Route 92 bottom left, Adams ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Aerial view southeast, State Route 92 bottom left, Adams Dam Road center, Brandywine Creek State Park and J. Chandler Farm in center left, duck pond bottom right and reservoir bottom left. - Winterthur Farms, Intersection State Routes 92 & 100, Intersection State Routes 92 & 100, Winterthur, New Castle County, DE

  16. Restoration advisory board expanding public involvement process at Rocky Mountain Arsenal

    SciTech Connect

    Mecham, R.; Blose, K.

    1995-12-31

    The Rocky Mountain Arsenal (Arsenal) is a federal enclave covering more than 17,000 acres (27 square miles) bounded by Adams County, Colorado, on the north and west, and the City and County of Denver on the south and east. In February 1989, two administrative agreements were signed to ensure the Arsenal cleanup program was carried out in a smooth and responsible manner. The Federal Facility Agreement (FFA) and the Settlement Agreement (SA) define how appropriate remedial actions Will be determined and the technical and financial responsibilities for each party involved. The FFA also defines how Interim Response Actions (IRAs) will be carried out, consistent with the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) and the National Contingency Plan (NCP). The IRAs are designed to support and be consistent with the final Record of Decision (ROD), which describes the final remediation plan for the Arsenal. When this decision is made in 1996, the IRAs will either be completed or be incorporated as part of the final cleanup plan.

  17. New Mathematical Dimensions: Adam's Story

    ERIC Educational Resources Information Center

    Manizade, Agida

    2009-01-01

    Adam, an 11th grader, was identified as gifted and accepted into a two week summer enrichment program. He signed up for "Geometry with Flash Programming." He had no prior programming experience but had a strong and healthy self-image as mathematics student. Although Adam had a positive attitude toward mathematics and saw himself as a successful…

  18. 25. AERIAL VIEW OF THE ROCKY FLATS PLANT LOOKING WEST ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    25. AERIAL VIEW OF THE ROCKY FLATS PLANT LOOKING WEST - NORTHWEST IN 1974. IN 1972, 4,600 ACRES WERE PURCHASED AROUND THE SITE TO BETTER PROTECT THE BORDERS FROM TERRORISM AND INFILTRATION BY PROTESTORS. ANTI-NUCLEAR DEMONSTRATION BEGAN SHORTLY AFTER THE 1969 FIRE IN BUILDING 776/777, AND CONTINUED UNTIL PRODUCTION CEASED AT THE PLANT IN 1989 (10/7/74). - Rocky Flats Plant, Bounded by Indiana Street & Routes 93, 128 & 72, Golden, Jefferson County, CO

  19. 20. AERIAL VIEW OF THE ROCKY FLATS PLANT LOOKING NORTHEAST. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    20. AERIAL VIEW OF THE ROCKY FLATS PLANT LOOKING NORTHEAST. THE PLANT WAS COMPOSED OF FOUR WIDELY SEPARATED AREAS, EACH ONE PERFORMING A DIFFERENT TYPE OF WORK. PLANT A (44), SOUTHWEST, FABRICATED PARTS FROM DEPLETED URANIUM, PLANT B (81), SOUTH, WAS ENRICHED URANIUM OPERATIONS, PLANT C (71), NORTH, PLUTONIUM OPERATIONS, AND PLANT D (91), EAST, WAS FINAL ASSEMBLY, SHIPPING AND RECEIVING (2/6/66). - Rocky Flats Plant, Bounded by Indiana Street & Routes 93, 128 & 72, Golden, Jefferson County, CO

  20. 21. AERIAL VIEW OF THE ROCKY FLATS PLANT LOOKING NORTHWEST. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    21. AERIAL VIEW OF THE ROCKY FLATS PLANT LOOKING NORTHWEST. BY THE LATE 1960S, THE SITE HAD UNDERGONE TWO MAJOR EXPANSIONS. THE FIRST EXPANSION IN 1956-57, WHEN THE TRIGGER DESIGN CHANGED AND NECESSITATED THE ADDITION OF SEVEN NEW BUILDINGS. THE SECOND LARGE EXPANSION TOOK PLACE FROM 1964-65, WHEN ROCKY FLATS BECAME THE SOLE PRODUCER OF TRIGGERS. DURING THIS EXPANSION, ELEVEN BUILDINGS WERE ADDED, PRIMARILY IN RESEARCH AND DEVELOPMENT LABORATORIES, GUARD HOUSES, AND WASTE WATER TREATMENT (7/1/69). - Rocky Flats Plant, Bounded by Indiana Street & Routes 93, 128 & 72, Golden, Jefferson County, CO

  1. The Adams family.

    PubMed

    Douven, Igor; Verbrugge, Sara

    2010-12-01

    According to Adams's Thesis, the acceptability of an indicative conditional sentence goes by the conditional probability of its consequent given its antecedent. We test, for the first time, whether this thesis is descriptively correct and show that it is not; in particular, we show that it yields the wrong predictions for people's judgments of the acceptability of important subclasses of the class of inferential conditionals. Experimental results are presented that reveal an interaction effect between, on the one hand, the type of inferential connection between a conditional's antecedent and its consequent and, on the other, the judged acceptability of the conditional in relation to the conditional probability of its consequent given its antecedent. Specifically, these results suggest a family of theses, each pertaining to a different type of conditional, about how conditionals relate to the relevant conditional probabilities.

  2. 76 FR 27173 - Carolina Coastal Railway, Inc.-Acquisition and Operation Exemption-Rocky Mount & Western Railroad...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-10

    ... Surface Transportation Board Carolina Coastal Railway, Inc.--Acquisition and Operation Exemption--Rocky Mount & Western Railroad Co., Inc. d/b/a Nash County Railroad Carolina Coastal Railway, Inc. (CLNA), a... Rocky Mount & Western Railroad Co., Inc. d/b/a Nash County Railroad (NCR), and to operate,...

  3. John Adams - an outstanding career.

    PubMed

    Lewin, David

    2016-12-07

    A distinguished nurse, teacher, researcher and historian, John Adams was educated at Aylesbury Grammar School and graduated from Selwyn College, Cambridge, with a degree in theological and religious studies.

  4. Evolution of Vertebrate Adam Genes; Duplication of Testicular Adams from Ancient Adam9/9-like Loci

    PubMed Central

    Wei, Shuo

    2015-01-01

    Members of the disintegrin metalloproteinase (ADAM) family have important functions in regulating cell-cell and cell-matrix interactions as well as cell signaling. There are two major types of ADAMs: the somatic ADAMs (sADAMs) that have a significant presence in somatic tissues, and the testicular ADAMs (tADAMs) that are expressed predominantly in the testis. Genes encoding tADAMs can be further divided into two groups: group I (intronless) and group II (intron-containing). To date, tAdams have only been reported in placental mammals, and their evolutionary origin and relationship to sAdams remain largely unknown. Using phylogenetic and syntenic tools, we analyzed the Adam genes in various vertebrates ranging from fishes to placental mammals. Our analyses reveal duplication and loss of some sAdams in certain vertebrate species. In particular, there exists an Adam9-like gene in non-mammalian vertebrates but not mammals. We also identified putative group I and group II tAdams in all amniote species that have been examined. These tAdam homologues are more closely related to Adams 9 and 9-like than to other sAdams. In all amniote species examined, group II tAdams lie in close vicinity to Adam9 and hence likely arose from tandem duplication, whereas group I tAdams likely originated through retroposition because of their lack of introns. Clusters of multiple group I tAdams are also common, suggesting tandem duplication after retroposition. Therefore, Adam9/9-like and some of the derived tAdam loci are likely preferred targets for tandem duplication and/or retroposition. Consistent with this hypothesis, we identified a young retroposed gene that duplicated recently from Adam9 in the opossum. As a result of gene duplication, some tAdams were pseudogenized in certain species, whereas others acquired new expression patterns and functions. The rapid duplication of Adam genes has a major contribution to the diversity of ADAMs in various vertebrate species. PMID:26308360

  5. Evolution of Vertebrate Adam Genes; Duplication of Testicular Adams from Ancient Adam9/9-like Loci.

    PubMed

    Bahudhanapati, Harinath; Bhattacharya, Shashwati; Wei, Shuo

    2015-01-01

    Members of the disintegrin metalloproteinase (ADAM) family have important functions in regulating cell-cell and cell-matrix interactions as well as cell signaling. There are two major types of ADAMs: the somatic ADAMs (sADAMs) that have a significant presence in somatic tissues, and the testicular ADAMs (tADAMs) that are expressed predominantly in the testis. Genes encoding tADAMs can be further divided into two groups: group I (intronless) and group II (intron-containing). To date, tAdams have only been reported in placental mammals, and their evolutionary origin and relationship to sAdams remain largely unknown. Using phylogenetic and syntenic tools, we analyzed the Adam genes in various vertebrates ranging from fishes to placental mammals. Our analyses reveal duplication and loss of some sAdams in certain vertebrate species. In particular, there exists an Adam9-like gene in non-mammalian vertebrates but not mammals. We also identified putative group I and group II tAdams in all amniote species that have been examined. These tAdam homologues are more closely related to Adams 9 and 9-like than to other sAdams. In all amniote species examined, group II tAdams lie in close vicinity to Adam9 and hence likely arose from tandem duplication, whereas group I tAdams likely originated through retroposition because of their lack of introns. Clusters of multiple group I tAdams are also common, suggesting tandem duplication after retroposition. Therefore, Adam9/9-like and some of the derived tAdam loci are likely preferred targets for tandem duplication and/or retroposition. Consistent with this hypothesis, we identified a young retroposed gene that duplicated recently from Adam9 in the opossum. As a result of gene duplication, some tAdams were pseudogenized in certain species, whereas others acquired new expression patterns and functions. The rapid duplication of Adam genes has a major contribution to the diversity of ADAMs in various vertebrate species.

  6. Adam Smith on population.

    PubMed

    Spengler, J J

    1970-11-01

    Abstract Adam Smith dealt with questions of population mainly in his Wealth of Nations. His discussion falls roughly under five heads and reflects in considerable measure his image of the English economy. (1) A country's population capacity, given the average level of consumption, was conditioned by the stock of land, the skill with which it was cultivated, and the degree to which division of labour could be increased and thereby augment output for domestic use and sale in external markets. (2) Growth of population was essentially in response to growth of the demand for labour and served to increase division of labour. (3) The social mechanisms underlying elevation of the scale of living are touched upon, and in an optimistic spirit. (4) The distribution of a country's population responded to its progress in opulence, with the rate of this progress conditioned by the degree to which inappropriate (e.g. mercantilist) policies were avoided. (5) Smith dealt briefly with such matters as colonies, education, size of economy, environmental influences, and public policy, all of which he recognized as significant for the quantity and quality of a country's numbers.

  7. Adam Smith and dependency.

    PubMed

    Ozler, Sule

    2012-06-01

    The focus of this paper is the works and life of Adam Smith, who is widely recognized as the father and founder of contemporary economics. Latent content analysis is applied to his seminal text in economics, An Inquiry into the Nature and Causes of the Wealth of Nations (1776). The results reveal that Smith considers dependence on others a problem and sees the solution to this problem in impersonalized interdependence. In addition, his views on social dependency and personal dependency, reflected in his Lectures on Jurisprudence (1963) and The Theory of Moral Sentiments (1759), are analyzed. This analysis suggests a central tension between dependence and independence in Smith's writings. The personal dependency patterns he exhibited in his life, which also suggest a tension between dependence and independence, are identified through a reading of his biographies. Based on insights from psychoanalytic literature, this paper proposes that developing the ideas in the Wealth of Nations was part of Smith's creative solution to this tension. In particular, his solution to one individual's dependence on another was through a system of impersonalized interdependence. In other words, Smith defended against his personal dependence through his economic theorizing.

  8. Late glacial aridity in southern Rocky Mountains

    SciTech Connect

    Davis, O.K.; Pitblado, B.L.

    1995-09-01

    While the slopes of the present-day Colorado Rocky Mountains are characterized by large stands of subalpine and montane conifers, the Rockies of the late glacial looked dramatically different. Specifically, pollen records suggest that during the late glacial, Artemisia and Gramineae predominated throughout the mountains of Colorado. At some point between 11,000 and 10,000 B.P., however, both Artemisia and grasses underwent a dramatic decline, which can be identified in virtually every pollen diagram produced for Colorado mountain sites, including Como Lake (Sangre de Cristo Mountains), Copley Lake and Splains; Gulch (near Crested Butte), Molas Lake (San Juan Mountains), and Redrock Lake (Boulder County). Moreover, the same pattern seems to hold for pollen spectra derived for areas adjacent to Colorado, including at sites in the Chuska Mountains of New Mexico and in eastern Wyoming. The implications of this consistent finding are compelling. The closest modem analogues to the Artemisia- and Gramineae-dominated late-glacial Colorado Rockies are found in the relatively arid northern Great Basin, which suggests that annual precipitation was much lower in the late-glacial southern Rocky Mountains than it was throughout the Holocene.

  9. Synthetic Minor NSR Permit: Tesoro Logistics-Rockies - Ponderosa Compressor Station

    EPA Pesticide Factsheets

    This page contains documents related to the synthetic minor NSR permit for the Tesoro Logistics-Rockies Ponderosa Compressor Station, located on the Uintah and Ouray Indian Reservation in Uintah County, UT.

  10. 5. VIEW LOOKING NORTHWEST OF BUILDING 444. (1/1/98) Rocky ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. VIEW LOOKING NORTHWEST OF BUILDING 444. (1/1/98) - Rocky Flats Plant, Non-Nuclear Production Facility, South of Cottonwood Avenue, west of Seventh Avenue & east of Building 460, Golden, Jefferson County, CO

  11. 4. VIEW LOOKING SOUTHEAST AT BUILDING 444. (1/1/98) Rocky ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. VIEW LOOKING SOUTHEAST AT BUILDING 444. (1/1/98) - Rocky Flats Plant, Non-Nuclear Production Facility, South of Cottonwood Avenue, west of Seventh Avenue & east of Building 460, Golden, Jefferson County, CO

  12. 26. AERIAL VIEW OF THE ROCKY FLATS PLANT LOOKING NORTHEAST. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    26. AERIAL VIEW OF THE ROCKY FLATS PLANT LOOKING NORTHEAST. IN 1951, A GOOD FRIDAY ISSUE OF THE DENVER POST ANNOUNCED THE ATOMIC ENERGY COMMISSION'S PLANS TO BUILD THE ROCKY FLATS PLANT. UNDER THE HEADLINE 'THERE'S GOOD NEWS TODAY.' POLITICAL LEADERS EXPRESSED GREAT PRIDE IN THE CHOICE OF THE DENVER-BOULDER AREA AS THE SITE FOR AN ATOMIC PLANT AS QUOTED IN THE ROCKY MOUNTAIN NEWS: 'WE ARE PROUD THAT THE AREA HAS BEEN CHOSEN FOR ANOTHER IMPORTANT CONTRIBUTION TO THE NATION'S STRENGTH AND FUTURE SECURITY.' BY THE MID 1970S, PUBLIC OPINION OF THE SITE HAD CHANGED (5/4/78). - Rocky Flats Plant, Bounded by Indiana Street & Routes 93, 128 & 72, Golden, Jefferson County, CO

  13. 77. Rocky Knob Recreation area. View of the valley from ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    77. Rocky Knob Recreation area. View of the valley from Belcher's Curve. Notice that the scenic easement allows A the boundary of the parkway to disappear creating a park that appears bigger than it is. View to west-southwest. - Blue Ridge Parkway, Between Shenandoah National Park & Great Smoky Mountains, Asheville, Buncombe County, NC

  14. 76. Rocky Knob Recreation area, Belcher's Curve. View of a ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    76. Rocky Knob Recreation area, Belcher's Curve. View of a parkway scenic easement. These have helped preserve the rural character of the landscape through which the parkway passes. Facing east-southeast. - Blue Ridge Parkway, Between Shenandoah National Park & Great Smoky Mountains, Asheville, Buncombe County, NC

  15. 18. Rocky Mountain Viaduct. This view shows the stone faced ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    18. Rocky Mountain Viaduct. This view shows the stone faced arched piers. It is the only structure on the parkway with this feature. View is facing east. - Blue Ridge Parkway, Between Shenandoah National Park & Great Smoky Mountains, Asheville, Buncombe County, NC

  16. 251. Rocky Knob Recreation Area contact station. In the foreground ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    251. Rocky Knob Recreation Area contact station. In the foreground S one of the rock fins which is representative of the area. In the background is the contact station which opened as a gas station in September 1949. Facing northwest. - Blue Ridge Parkway, Between Shenandoah National Park & Great Smoky Mountains, Asheville, Buncombe County, NC

  17. 245. Rocky Mountain Viaduct. This steel girder viaduct was built ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    245. Rocky Mountain Viaduct. This steel girder viaduct was built in 1942. All of the reinforced concrete was faced with a rusticated stone. It is the only structure on the parkway with stone faced arched piers. The view is facing east. - Blue Ridge Parkway, Between Shenandoah National Park & Great Smoky Mountains, Asheville, Buncombe County, NC

  18. 17. Rocky Mountain viaduct. This steel girder viaduct was built ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    17. Rocky Mountain viaduct. This steel girder viaduct was built in 1942. All of the reinforced concrete was faced with a rustic stone facade. View is to east. - Blue Ridge Parkway, Between Shenandoah National Park & Great Smoky Mountains, Asheville, Buncombe County, NC

  19. 7. Photographic copy of photograph (Source: National Archives, Rocky Mountain ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Photographic copy of photograph (Source: National Archives, Rocky Mountain Region, Denver, Salt River Project History, Final History to 1916. p. 506) Interior view of transformer house. No date. CA. 1916. - Theodore Roosevelt Dam, Transformer House, Salt River, Tortilla Flat, Maricopa County, AZ

  20. 7. Photographic copy of photograph (Source: National Archives, Rocky Mountain ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Photographic copy of photograph (Source: National Archives, Rocky Mountain Region, Denver, Salt River Project History, Final History to 1916. p. 504) Inside Roosevelt power plant showing size of valve. CA. 1916. - Theodore Roosevelt Dam, Power Plant, Salt River, Tortilla Flat, Maricopa County, AZ

  1. ADAM12 — EDRN Public Portal

    Cancer.gov

    ADAM12 is a member of the ADAM (a disintegrin and metalloprotease) protein family. ADAM family members are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions. ADAM12 has two alternatively spliced transcripts: a shorter secreted form and a longer membrane-bound form. The shorter form is found to stimulate myogenesis.

  2. What's an Adam's Apple? (For Kids)

    MedlinePlus

    ... Happens in the Operating Room? What's an Adam's Apple? KidsHealth > For Kids > What's an Adam's Apple? A A A You're at the high ... the throat. This is what's called an Adam's apple. Everyone's larynx grows during puberty, but a girl's ...

  3. Historians' Rocky Job Market

    ERIC Educational Resources Information Center

    Grafton, Anthony; Townsend, Robert B.

    2008-01-01

    In this article, the authors discuss how the historians' job market is perennially rocky. The history profession had its "golden age" in the 1950s and early 1960s when a generation born in the demographic trench of the Depression entered the market just as the first of the baby boomers began to swell college enrollments. But that moment was…

  4. Rocky Mountain Spotted Fever.

    PubMed

    Phillips, Jennan

    2017-01-01

    The tick-borne disease Rocky Mountain spotted fever (RMSF) can have deadly outcomes unless treated appropriately, yet nonspecific flu-like symptoms complicate diagnosis. Occupational health nurses must have a high index of suspicion with symptomatic workers and recognize that recent recreational or occupational activities with potential tick exposure may suggest RMSF.

  5. Superfund Record of Decision (EPA Region 8): Rocky Mountain Arsenal (Operable Unit 26), CO. (Tenth remedial action), September 1991

    SciTech Connect

    Not Available

    1991-09-05

    The Rocky Mountain Arsenal (RMA) (Operable Unit 26) site comprises part of the 17,000-acre RMA site, which is a former U.S. Army chemical warfare and incendiary munitions manufacturing and assembly plant in Adams County, Colorado. Since 1970, U.S. Army facility operations primarily have involved the destruction of chemical warfare materials. Because final remediation of the RMA site will take many years to complete, 13 interim response actions (IRAs) were determined necessary prior to implementing the final On-Post Record of Decision (ROD). Operable Unit 26 (OU26), which is one of these 13 IRAs, is composed of the piping and equipment in the buildings in the North and South Plants at RMA. The ROD addresses contaminated piping and equipment in numerous buildings in the North and South Plants, and contaminated 1-ton containers. The primary contaminants of concern affecting the debris and air are the chemical agents GB (Agent GB, Sarin), HD (Agent Mustard), L (Agent Lewisite), and VX (Agent VX). The selected remedial action for the site is included.

  6. Rocky Mountain spotted fever.

    PubMed

    Lacz, N L; Schwartz, R A; Kapila, R

    2006-04-01

    Rocky Mountain spotted fever (RMSF) is an unusual but important dermatological condition to identify without hesitation. The classic triad of headache, fever, and a rash that begins on the extremities and travels proximally to involve the trunk is found in a majority of patients. The cutaneous centripetal pattern is a result of cell to cell migration by the causative organism Rickettsia rickettsii. Such individuals should receive prompt antimicrobial therapy and supportive care to avoid serious and potentially fatal complications.

  7. Rocky Mountain spotted fever.

    PubMed

    Kamper, C A; Chessman, K H; Phelps, S J

    1988-02-01

    The epidemiology, pathogenesis, clinical features, and treatment of Rocky Mountain spotted fever are reviewed. Rocky Mountain spotted fever is a severe infection caused by Rickettsia rickettsii transmitted to man by various species of ticks. High-incidence areas exist in the southeast and south central United States. Only 60-70% of patients with the disease report a history of tick bite or exposure to tick-infested areas. The disease is initially characterized by fever, headache, gastrointestinal complaints, myalgia, and a generalized rash. In several days generalized vasculitis may lead to periorbital edema and nonpitting edema of the face and extremities. Central nervous system involvement is common. Because signs and symptoms associated with the disease are nonspecific, the diagnosis is often delayed or missed. Traditionally diagnostic confirmation relied on serologic testing, but an indirect fluorescent antibody assay will soon be commercially available. Rocky Mountain spotted fever is usually treated with the rickettsiostatic agents chloramphenicol or tetracycline, but few comparative data on these agents in patients with the disease are available. For patients who cannot tolerate oral medications, intravenous chloramphenicol sodium succinate is the preferred treatment; chloramphenicol is also the drug of choice for children less than eight years of age. Otherwise, oral tetracycline hydrochloride is the drug of choice. Antibiotic therapy should be continued for 7-10 days or until the patient is afebrile for two to five days. All cases of Rocky Mountain spotted fever must be reported to the Centers for Disease Control. The best ways to decrease the morbidity and mortality of the disease are to increase awareness of its signs and symptoms and to prevent exposure to ticks.

  8. ADAM 12: A Putative Marker of Oligodendrogliomas?

    PubMed Central

    Kanakis, Dimitrios; Lendeckel, Uwe; Theodosiou, Paraskevi; Dobrowolny, Henrik; Mawrin, Christian; Keilhoff, Gerburg; Bukowska, Alicia; Dietzmann, Knut; Bogerts, Bernhard; Bernstein, Hans-Gert

    2013-01-01

    ADAM 12 (meltrin alpha) belongs to a large family of molecules, consisting of members with both disintegrin and metalloproteinase properties. ADAMs have been implicated in several cell physiological processes including cell adhesion, cell fusion, proteolysis and signalling. ADAM 12 is widely expressed, including skeletal muscle, testis, bone, intestine, heart and kidney. In addition, a variety of tumours show elevated expression of ADAM12; among them being breast-, colon-, gastric- and lung-carcinoma. As to the brain, ADAM 12 has been shown previously to be expressed in rat and human oligodendrocytes. However, little is known about the expression of this protease in brain tumours. This study demonstrates the presence of ADAM 12 in non-neoplastic oligodendroglial cells of normal human brain as well as in neoplastic oligodendroglia and minigemistocytes arising from four pure oligodendrogliomas and three mixed oligoastrocytomas. Double stainings revealed a notable preference of ADAM 12 for the oligodendroglial over astroglial components. The results of immunohistochemistry are in accordance with the results obtained from the RT-PCR, which further demonstrated a mild difference concerning the mRNA concentration of ADAM 12 between similar grades of eight astrocytomas and eight oligodendrogliomas (namely four astrocytomas grade II versus four oligodendrogliomas grade II and four astrocytomas grade III versus four oligodendrogliomas grade III). Both cellular immunostaining for ADAM 12 and ADAM 12 mRNA content decrease with higher histologic grade of the tumour. Surprisingly, the latter parameter (ADAM12 mRNA) showed a significant opposite correlation to the degree of histologic tumour malignancy. From our data showing that ADAM 12 is highly expressed in, but not restricted to, oligodendrogliomas, we conclude that ADAM 12 immunohistochemistry may be a helpful tool in the diagnosis of brain tumours. PMID:23324579

  9. ADAM 12: a putative marker of oligodendrogliomas?

    PubMed

    Kanakis, Dimitrios; Lendeckel, Uwe; Theodosiou, Paraskevi; Dobrowolny, Henrik; Mawrin, Christian; Keilhoff, Gerburg; Bukowska, Alicia; Dietzmann, Knut; Bogerts, Bernhard; Bernstein, Hans-Gert

    2013-01-01

    ADAM 12 (meltrin alpha) belongs to a large family of molecules, consisting of members with both disintegrin and metalloproteinase properties. ADAMs have been implicated in several cell physiological processes including cell adhesion, cell fusion, proteolysis and signalling. ADAM 12 is widely expressed, including skeletal muscle, testis, bone, intestine, heart and kidney. In addition, a variety of tumours show elevated expression of ADAM12; among them being breast-, colon-, gastric- and lung-carcinoma. As to the brain, ADAM 12 has been shown previously to be expressed in rat and human oligodendrocytes. However, little is known about the expression of this protease in brain tumours. This study demonstrates the presence of ADAM 12 in non-neoplastic oligodendroglial cells of normal human brain as well as in neoplastic oligodendroglia and minigemistocytes arising from four pure oligodendrogliomas and three mixed oligoastrocytomas. Double stainings revealed a notable preference of ADAM 12 for the oligodendroglial over astroglial components. The results of immunohistochemistry are in accordance with the results obtained from the RT-PCR, which further demonstrated a mild difference concerning the mRNA concentration of ADAM 12 between similar grades of eight astrocytomas and eight oligodendrogliomas (namely four astrocytomas grade II versus four oligodendrogliomas grade II and four astrocytomas grade III versus four oligodendrogliomas grade III). Both cellular immunostaining for ADAM 12 and ADAM 12 mRNA content decrease with higher histologic grade of the tumour. Surprisingly, the latter parameter (ADAM12 mRNA) showed a significant opposite correlation to the degree of histologic tumour malignancy. From our data showing that ADAM 12 is highly expressed in, but not restricted to, oligodendrogliomas, we conclude that ADAM 12 immunohistochemistry may be a helpful tool in the diagnosis of brain tumours.

  10. Differential Surface Expression of ADAM10 and ADAM17 on Human T Lymphocytes and Tumor Cells

    PubMed Central

    Kabelitz, Dieter; Janssen, Ottmar

    2013-01-01

    A disintegrin and metalloproteases (ADAMs) have been implicated in many processes controlling organismic development and integrity. Important substrates of ADAM proteases include growth factors, cytokines and their receptors and adhesion proteins. The inducible but irreversible cleavage of their substrates alters cell-cell communication and signaling. The crucial role of ADAM proteases (e.g. ADAM10 and 17) for mammalian development became evident from respective knockout mice, that displayed pre- or perinatal lethality with severe defects in many organs and tissues. Although many substrates for these two ADAM proteases were identified over the last decade, the regulation of their surface appearance, their enzymatic activity and their substrate specificity are still not well understood. We therefore analyzed the constitutive and inducible surface expression of ADAM10 and ADAM17 on a variety of human T cell and tumor cell lines. We demonstrate that ADAM10 is constitutively present at comparably high levels on the majority of the tested cell types. Stimulation with phorbol ester and calcium ionophore does not significantly alter the amount of surface ADAM10, except for a slight down-regulation from T cell blasts. Using FasL shedding as a readout for ADAM10 activity, we show that PKC activation and calcium mobilization are both prerequisite for activation of ADAM10 resulting in a production of soluble FasL. In contrast to ADAM10, the close relative ADAM17 is detected at only low levels on unstimulated cells. ADAM17 surface expression on T cell blasts is rapidly induced by stimulation. Since this inducible mobilization of ADAM17 is sensitive to inhibitors of actin filament formation, we propose that ADAM17 but not ADAM10 is prestored in a subcellular compartment that is transported to the cell surface in an activation- and actin-dependent manner. PMID:24130797

  11. 13. AERIAL VIEW OF THE ROCKY FLATS PLANT FROM DIRECTLY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. AERIAL VIEW OF THE ROCKY FLATS PLANT FROM DIRECTLY OVERHEAD IN 1954. IN 1950, DOW CHEMICAL COMPANY WAS CHOSEN BY THE ATOMIC ENERGY COMMISSION TO ESTABLISH THE ROCKY FLATS PLANT AS AN ATOMIC BOMB TRIGGER FABRICATION FACILITY. THE CRITERIA FOR SITING SUCH A PLANT INCLUDED A LOCATION WEST OF THE MISSISSIPPI, NORTH OF TEXAS, SOUTH OF THE NORTHERN BORDER OF COLORADO, AND EAST OF UTAH; A DRY MODERATE CLIMATE; A SUPPORTING POPULATION OF AT LEAST 25,000 PEOPLE; AND ACCESSIBILITY FROM LOS ALAMOS, NM, CHICAGO, IL, AND ST. LOUIS, MO. TWENTY-ONE AREAS IN THE UNITED STATES WERE SUGGESTED; SEVEN LOCATIONS WERE SCREENED IN THE DENVER AREA. THIS FOUR-SQUARE MILE AREA WAS SELECTED AND CONSTRUCTION BEGAN IN 1951 (8/31/54). - Rocky Flats Plant, Bounded by Indiana Street & Routes 93, 128 & 72, Golden, Jefferson County, CO

  12. ADAMS: AIRLAB data management system user's guide

    NASA Technical Reports Server (NTRS)

    Conrad, C. L.; Ingogly, W. F.; Lauterbach, L. A.

    1986-01-01

    The AIRLAB Data Management System (ADAMS) is an online environment that supports research at NASA's AIRLAB. ADAMS provides an easy to use interactive interface that eases the task of documenting and managing information about experiments and improves communication among project members. Data managed by ADAMS includes information about experiments, data sets produced, software and hardware available in AIRLAB as well as that used in a particular experiment, and an on-line engineer's notebook. The User's Guide provides an overview of the ADAMS system as well as details of the operations available within ADAMS. A tutorial section takes the user step-by-step through a typical ADAMS session. ADAMS runs under the VAX/VMS operating system and uses the ORACLE database management system and DEC/FMS (the Forms Management System). ADAMS can be run from any VAX connected via DECnet to the ORACLE host VAX. The ADAMS system is designed for simplicity, so interactions within the underlying data management system and communications network are hidden from the user.

  13. [Rocky Mountain spotted fever].

    PubMed

    Reinauer, K M; Jaschonek, K; Kusch, G; Heizmann, W R; Döller, P C; Jenss, H

    1990-01-12

    After returning from a holiday in the USA a 24-year-old man fell ill with diarrhoea, high fever and marked rash including the palms of the hands and soles of the feet. When a history of a tick bite in the USA was elicited, a rickettsial infection was suspected. Treatment with doxycycline, 100 mg twice daily, was instituted finally and the fever slowly resolved. The patient became completely well again within four weeks. Serological tests confirmed the diagnosis of Rocky Mountain spotted fever.

  14. Asteroid shape modelling with ADAM

    NASA Astrophysics Data System (ADS)

    Viikinkoski, Matti; Kaasalainen, Mikko; Durech, Josef

    2015-08-01

    Technological advancements have made it possible to obtain highly detailed images of asteroids, yet 3-D shape reconstruction remains a challenge. Shape inversion is an ill-posed inverse problem as systematic errors, shadowing effects due to non-convex features, and the limitations of the imaging systems render the direct inversion impossible. Moreover, the coverage of one observation session alone is seldom sufficient for 3-D reconstruction, necessitating a method for the integration of widely different, complementary data sources into a coherent shape solution.We present a new 3-D shape reconstruction method for asteroid models. ADAM, an acronym for all-data asteroid modelling, is a general procedure for combining disk-resolved observational data into a shape model. ADAM handles all disk-resolved data in a uniform manner via 2-D Fourier Transform. Almost all disk-resolved data sources are supported: adaptive optics and other images, range-Doppler radar data, and thermal infrared interferometry.As case studies, we examine the shape of (41) Daphne using the adaptive optics images and photometry, and create a model of the asteroid 2000 ET70 from the range-Doppler radar images. Finally, we combine ALMA science verification data, adaptive optics images, occultations, and lightcurve data to study the shape of the large main-belt asteroid (3) Juno.

  15. The Historical World of Henry Adams

    ERIC Educational Resources Information Center

    Blaser, Kent

    1976-01-01

    This paper examines Henry Adams' writings on history by considering four topics which comprise the basis of his thinking: politics, religion, sex, and science. Adam's main goal was to make history a means of exploring the most significant dimensions of human being. (Author/RM)

  16. 4. SEGMENT OF LATERAL WEST OF C STREET (SECTION 10) ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. SEGMENT OF LATERAL WEST OF C STREET (SECTION 10) ON THE ROCKY MOUNTAIN ARSENAL (RMA). - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  17. ADAMs family and relatives in cardiovascular physiology and pathology.

    PubMed

    Zhang, Pu; Shen, Mengcheng; Fernandez-Patron, Carlos; Kassiri, Zamaneh

    2016-04-01

    A disintegrin and metalloproteinases (ADAMs) are a family of membrane-bound proteases. ADAM-TSs (ADAMs with thrombospondin domains) are a close relative of ADAMs that are present in soluble form in the extracellular space. Dysregulated production or function of these enzymes has been associated with pathologies such as cancer, asthma, Alzheimer's and cardiovascular diseases. ADAMs contribute to angiogenesis, hypertrophy and apoptosis in a stimulus- and cell type-dependent manner. Among the ADAMs identified so far (34 in mouse, 21 in human), ADAMs 8, 9, 10, 12, 17 and 19 have been shown to be involved in cardiovascular development or cardiomyopathies; and among the 19 ADAM-TSs, ADAM-TS1, 5, 7 and 9 are important in development of the cardiovascular system, while ADAM-TS13 can contribute to vascular disorders. Meanwhile, there remain a number of ADAMs and ADAM-TSs whose function in the cardiovascular system has not been yet explored. The current knowledge about the role of ADAMs and ADAM-TSs in the cardiovascular pathologies is still quite limited. The most detailed studies have been performed in other cell types (e.g. cancer cells) and organs (nervous system) which can provide valuable insight into the potential functions of ADAMs and ADAM-TSs, their mechanism of action and therapeutic potentials in cardiomyopathies. Here, we review what is currently known about the structure and function of ADAMs and ADAM-TSs, and their roles in development, physiology and pathology of the cardiovascular system.

  18. Molecular profiling of ADAM12 and ADAM17 genes in human malignant melanoma.

    PubMed

    Cireap, Natalia; Narita, Diana

    2013-10-01

    ADAM12 and ADAM17 proteins belong to a family of transmembrane disintegrin-containing metalloproteinases (ADAMs) involved in the proteins ectodomain shedding and cell-cell and cell-matrix interactions. However, the specific biological functions of ADAMs are still unclear and, until now, these proteins were not investigated yet in melanoma. The aim of this study was to analyze the splicing variants of ADAM12 (L and S) and ADAM17 gene expression in melanoma at transcriptional and translational level in comparison with control (non-tumor) tissues. Taking in account that ADAM17 sheddase is involved in the modulation of TNF-α (tumor necrosis factor alpha), we analyzed also this cytokine in the plasma of the same patients before any treatment, and we compared the results with healthy controls. Quantitative-RT-PCR and immunohistochemistry were used to analyze ADAM12 and ADAM17 genes expression and the analysis of TNF-α expression was carried out in the plasma using ELISA. We demonstrated that ADAM12L splicing variant together with ADAM17 gene are strongly overexpressed in melanomas, whereas ADAM12S, although up-regulated when compared with the non-tumor controls, the difference was not statistically significant. When we compared the levels of expression for the ADAMs genes according to the tumor stage, we observed that all three investigated genes were significantly overexpressed in advanced stage in comparison with early stage melanomas. In the plasma of the same patients, the expression of TNF-α was up-regulated and significantly correlated with the expression of ADAM17 and respectively, with the advanced tumor stage.

  19. Rocky Mountain spotted fever.

    PubMed

    Dantas-Torres, Filipe

    2007-11-01

    Rocky Mountain spotted fever (RMSF) is a life-threatening disease caused by Rickettsia rickettsii, an obligately intracellular bacterium that is spread to human beings by ticks. More than a century after its first clinical description, this disease is still among the most virulent human infections identified, being potentially fatal even in previously healthy young people. The diagnosis of RMSF is based on the patient's history and a physical examination, and often presents a dilemma for clinicians because of the non-specific presentation of the disease in its early course. Early empirical treatment is essential to prevent severe complications or a fatal outcome, and treatment should be initiated even in unconfirmed cases. Because there is no vaccine available against RMSF, avoidance of tick-infested areas is still the best way to prevent the infection.

  20. Identification of ADAM10 and ADAM17 with potential roles in the spermatogenesis of the Chinese mitten crab, Eriocheir sinensis.

    PubMed

    Li, Qing; Xie, Jing; He, Lin; Wang, Yuanli; Duan, Zelin; Yang, Hongdan; Wang, Qun

    2015-05-10

    The ADAM (a disintegrin and metalloprotease) family plays an important role in sperm and egg fusion, development, inflammation, adhesion and migration. ADAM10 and ADAM17 are involved in the spermatogenesis. To better understand the role of ADAM10 and ADAM17 in the Chinese mitten crab, Eriocheir sinensis, the full-length cDNAs of ADAM10 and ADAM17 were cloned, and named Es-ADAM10 and Es-ADAM17, respectively. Sequence and structural analysis showed that Es-ADAM10 and Es-ADAM17 have the typical structure of the ADAM family. Quantitative real-time reverse transcription polymerase chain reaction analysis showed that Es-ADAM10 and Es-ADAM17 mRNAs were distributed in the heart, hepatopancreas, intestines, brain, muscle, thoracic ganglia, hemolymph, stomach, testis, ovary, gill and accessory gland. Both mRNAs were highly expressed in the muscles, and relatively high in the testis, ovary and accessory gland. In addition, the Es-ADAM17 mRNA level was detected in every stage of testis development, being relatively high from July to September, the lowest during October and November, increasing from December to January, and reached a peak in January. By contrast, the expression of Es-ADAM10 mRNA was constant during testis development. Immunofluorescence further showed that Es-ADAM10 and Es-ADAM17 proteins were present in the cytoplasm and cytomembrane of spermatocytes, and both detected in the sperm. Furthermore, etoposide induced upregulation of Es-ADAM17 and Es-ADAM10 at both the mRNA and protein levels. This study first showed that Es-ADAM10 and Es-ADAM17 were also involved in the spermatogenesis and mainly participated in the later germ cell apoptosis in E. sinensis.

  1. Cleavage Site Localization Differentially Controls Interleukin-6 Receptor Proteolysis by ADAM10 and ADAM17

    PubMed Central

    Riethmueller, Steffen; Ehlers, Johanna C.; Lokau, Juliane; Düsterhöft, Stefan; Knittler, Katharina; Dombrowsky, Gregor; Grötzinger, Joachim; Rabe, Björn; Rose-John, Stefan; Garbers, Christoph

    2016-01-01

    Limited proteolysis of the Interleukin-6 Receptor (IL-6R) leads to the release of the IL-6R ectodomain. Binding of the cytokine IL-6 to the soluble IL-6R (sIL-6R) results in an agonistic IL-6/sIL-6R complex, which activates cells via gp130 irrespective of whether the cells express the IL-6R itself. This signaling pathway has been termed trans-signaling and is thought to mainly account for the pro-inflammatory properties of IL-6. A Disintegrin And Metalloprotease 10 (ADAM10) and ADAM17 are the major proteases that cleave the IL-6R. We have previously shown that deletion of a ten amino acid long stretch within the stalk region including the cleavage site prevents ADAM17-mediated cleavage, whereas the receptor retained its full biological activity. In the present study, we show that deletion of a triple serine (3S) motif (Ser-359 to Ser-361) adjacent to the cleavage site is sufficient to prevent IL-6R cleavage by ADAM17, but not ADAM10. We find that the impaired shedding is caused by the reduced distance between the cleavage site and the plasma membrane. Positioning of the cleavage site in greater distance towards the plasma membrane abrogates ADAM17-mediated shedding and reveals a novel cleavage site of ADAM10. Our findings underline functional differences in IL-6R proteolysis by ADAM10 and ADAM17. PMID:27151651

  2. John Quincy Adams's rhetorical crusade for astronomy.

    PubMed

    Portolano, M

    2000-09-01

    Astronomy thrived in Europe during the early nineteenth century, but in the United States a utilitarian mind-set opposed it. John Quincy Adams's oratory in support of American astronomical discovery reached its peak during congressional debate over the Smithsonian Institution (1838-1846). During this debate Adams countered proposals to found a university with plans for an observatory. His addresses to congressional and public audiences about observatories and astronomy were intended to foster interest in the science and encourage the growing astronomical community in America. Although the U.S. Naval Observatory in Washington, D.C., was established before the Smithsonian debate ended, many considered Adams its political father. Adams composed his speeches on astronomy in a systematic manner, following neoclassical principles of rhetoric that he had taught at Harvard University. His speeches both in and outside of Congress show evidence of the rhetorical principles he conscientiously used in the service of astronomy.

  3. Rocky Martian Plain

    NASA Technical Reports Server (NTRS)

    1976-01-01

    The rocky Martian plain surrounding Viking 2 is seen in high resolution in this 85-degree panorama sweeping from north at the left to east at right during the Martian afternoon on September 5. Large blocks litter the surface. Some are porous, sponge-like rocks like the one at the left edge (size estimate: 1 1/2 to 2 feet); others are dense and fine-grained, such as the very bright rounded block (1 to 1 1/2 feet across) toward lower right. Pebbled surface between the rocks is covered in places by small drifts of very fine material similar to drifts seen at the Viking 1 landing site some 4600 miles to the southwest. The fine-grained material is banked up behind some rocks, but wind tails seen by Viking 1 are not well-developed here. On the right horizon, flat-topped ridges or hills are illuminated by the afternoon sun. Slope of the horizon is due to the 8-degree tilt of the spacecraft.

  4. Drought in the Rockies

    NASA Technical Reports Server (NTRS)

    2002-01-01

    This image shows the difference between the amount of vegetation in July 2000 and the average July vegetation for North America. Of particular interest are the dry conditions in the western United States. This spring and summer the Rocky Mountains have been relatively dry, and the brown regions stretching from the Canadian to the Mexican border, indicate the effect on the regions' forests. Western Montana and eastern Idaho are particularly parched, and appear darker brown. The dry conditions have contributed to this year's devastating fire season, during which millions of acres have burned in the west. Scientists find that during the growing season, land plants can be used to measure drought. Healthy, thriving plants reflect and absorb visible and near-infrared light differently than plants under stress. These variations in reflectance and absorption can be measured by satellites to produce maps of healthy and stressed vegetation. This image shows Normalized Difference Vegetation Index (NDVI) anomaly, which indicates where vegetation growth was above average (green pixels), below average (brown pixels), or normal (white pixels). For more images and information about measuring vegetation and drought from space visit: Drought and Vegetation Monitoring. Image courtesy NASA Goddard Space Flight Center Biospheric Sciences Branch, based on data from NOAA.

  5. Rocky road in the Rockies: Challenges to biodiversity

    USGS Publications Warehouse

    Tomback, Diana F.; Kendall, Katherine C.

    2002-01-01

    To people worldwide, the Rocky Mountains of the United States and Canada represent a last bastion of nature in its purest and rawest form-unspoiled forests teeming with elk and deer stalked by mountain lions and grizzly bears; bald eagles nesting near lakes and rivers; fat, feisty native trout in rushing mountain streams; and dazzling arrays of wildflowers in lush meadows. In fact, the total biodiversity of the Rocky Mountains is considerable, with relatively high diversity in birds, mammals, butterflies, reptiles, and conifers (Ricketts et al. 1999) and with geographic variation in the flora and fauna of alpine, forest, foothill, and adjacent shortgrass prairie and shrub communities over more than 20 degrees of latitude and more than 10' of longitude. Although the biodiversity of most North American regions has declined because of anthropogenic influences, the perception remains that the biodiversity of the Rocky Mountains is intact. This view exists in part because the Rocky Mountains are remote from urban centers, in part because so much of the land comprises protected areas such as national parks and wilderness areas, and in part because of wishful thinking-that nothing bad could happen to the biodiversity that is so much a part of the history, national self-image, legends, nature films, and movies of the United States and Canada. Despite modern technology and the homogenization and globalization of their cities and towns, at heart North Americans still regard their land as the New World, with pristine nature and untamed landscapes epitomized by the Rockies. The reality is that the biodiversity of the Rocky Mountains has not been free of anthropogenic influences since the West was settled in the 1800s, and in fact it was altered by Native Americans for centuries prior to settlement. A number of escalating problems and consequences of management choices are currently changing Rocky Mountain ecological communities at a dizzying pace. In Order to maintain some

  6. 32. AERIAL VIEW OF THE ROCKY FLATS PLANT LOOKING NORTHWEST. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    32. AERIAL VIEW OF THE ROCKY FLATS PLANT LOOKING NORTHWEST. DURING THE 1980S, A NUMBER OF COMPLAINTS CONCERNING SAFETY AND ENVIRONMENTAL ERRORS SURFACED, CULMINATING IN THE 1989 RAID ON THE PLANT BY THE FBI FOR ALLEGED ENVIRONMENTAL INFRACTIONS. THAT SAME YEAR, PRODUCTION AT THE PLANT WAS HALTED FOR CORRECTION OF SAFETY DEFICIENCIES. BY 1991, A SERIES OF EVENTS WORLDWIDE REDUCED THE COLD WAR THREAT, AND IN 1992, THE SECRETARY OF ENERGY ANNOUNCED THAT THE MISSION AT THE PLANT WOULD BE CHANGED TO ENVIRONMENTAL RESTORATION AND WASTE MANAGEMENT, WITH THE GOAL OF CLEANING UP THE PLANT AND SITE (1989). - Rocky Flats Plant, Bounded by Indiana Street & Routes 93, 128 & 72, Golden, Jefferson County, CO

  7. A Conversation with Adam Heller.

    PubMed

    Heller, Adam; Cairns, Elton J

    2015-01-01

    Adam Heller, Ernest Cockrell Sr. Chair in Engineering Emeritus of the John J. McKetta Department of Chemical Engineering at The University of Texas at Austin, recalls his childhood in the Holocaust and his contributions to science and technology that earned him the US National Medal of Technology and Innovation in a conversation with Elton J. Cairns, Professor of Chemical and Biomolecular Engineering at the University of California, Berkeley. Dr. Heller, born in 1933, describes the enslavement of his father by Hungarians in 1942; the confiscation of his family's home, business, and all its belongings in 1944; and his incarceration in a brick factory with 18,000 Jews who were shipped by the Hungarians to be gassed by Germans in Auschwitz. Dr. Heller and his immediate family survived the Holocaust and arrived in Israel in 1945. He studied under Ernst David Bergmann at the Hebrew University, and then worked at Bell Laboratories and GTE Laboratories, where he headed Bell Lab's Electronic Materials Research Department. At GTE Laboratories, he built in 1966 the first neodymium liquid lasers and in 1973 with Jim Auborn conceived and engineered the lithium thionyl chloride battery, one of the first to be manufactured lithium batteries, which is still in use. After joining the faculty of engineering of The University of Texas at Austin, he cofounded with his son Ephraim Heller TheraSense, now a major part of Abbott Diabetes Care, which produced a microcoulometer that made the monitoring of glucose painless by accurately measuring the blood glucose concentration in 300 nL of blood. He also describes the electrical wiring of enzymes, the basis for Abbott's state-of-the-art continuous glucose monitoring system. He discusses his perspective of reducing the risk of catastrophic global warming in a wealth-accumulating, more-energy-consuming world and provides advice for students entering careers in science or engineering.

  8. The Rocky Planet Survey

    NASA Astrophysics Data System (ADS)

    Fischer, Debra

    In direct support of the NASA Origins program, we propose the Rocky Planet Survey, a high cadence exoplanet search of sixty late G and K dwarf stars using the CHIRON spectrometer, which we built and commissioned at CTIO. CHIRON operates in two high- resolution modes (R=90,000 and R=120,000) and has a demonstrated precision of better than 1 m s-1. We are contributing 200 nights of telescope time for the next three years, for the excellent phase coverage needed to carry out this work. We have developed simulation software to optimize scheduling of observations to suppress aliases and quickly extract dynamical signals. Our science objectives are to (1) provide a statistical assessment of planet occurrence as a function of decreasing mass in the range of parameter space 3 < Msini < 30 MEARTH for orbital periods up to 50 days, (2) to determine the fraction of low mass planets in multi-planet architectures, and (3) detect planets with Msini < 3 MEARTH in orbital periods shorter than ~20 days. In addition to the science objectives, we intend to push the frontiers of extreme precision Doppler measurements to keep the U.S. competitive with the next generation of European Doppler spectroscopy (ESPRESSO on the VLT). Our team has significant expertise in optical design, fiber coupling, raw extraction, barycentric velocity corrections, and Doppler analysis. The proposed work includes a new optimal extraction algorithm, with the optical designers and software engineers working together on the 2-D PSF description needed for a proper row-by-row extraction and calibration. We will also develop and test upgrades to the barycentric correction code and improvements in the Doppler code that take advantage of stability in the dispersion solution, afforded by a new vacuum-enclosed grating upgrade (scheduled for November 2011). We will test use of emission wavelength calibrations to extend the iodine (absorption) wavelength calibration that we currently use to prepare for eventual use of

  9. ADAM: automated data management for research datasets

    PubMed Central

    Woodbridge, Mark; Tomlinson, Christopher D.; Butcher, Sarah A.

    2013-01-01

    Existing repositories for experimental datasets typically capture snapshots of data acquired using a single experimental technique and often require manual population and continual curation. We present a storage system for heterogeneous research data that performs dynamic automated indexing to provide powerful search, discovery and collaboration features without the restrictions of a structured repository. ADAM is able to index many commonly used file formats generated by laboratory assays and therefore offers specific advantages to the experimental biology community. However, it is not domain specific and can promote sharing and re-use of working data across scientific disciplines. Availability and implementation: ADAM is implemented using Java and supported on Linux. It is open source under the GNU General Public License v3.0. Installation instructions, binary code, a demo system and virtual machine image and are available at http://www.imperial.ac.uk/bioinfsupport/resources/software/adam. Contact: m.woodbridge@imperial.ac.uk PMID:23109181

  10. Rocky Mountain spotted fever, Colombia.

    PubMed

    Hidalgo, Marylin; Orejuela, Leonora; Fuya, Patricia; Carrillo, Pilar; Hernandez, Jorge; Parra, Edgar; Keng, Colette; Small, Melissa; Olano, Juan P; Bouyer, Donald; Castaneda, Elizabeth; Walker, David; Valbuena, Gustavo

    2007-07-01

    We investigated 2 fatal cases of Rocky Mountain spotted fever that occurred in 2003 and 2004 near the same locality in Colombia where the disease was first reported in the 1930s. A retrospective serosurvey of febrile patients showed that > 21% of the serum samples had antibodies aaainst spotted fever group rickettsiae.

  11. Rocky Mountain spotted fever, Panama.

    PubMed

    Estripeaut, Dora; Aramburú, María Gabriela; Sáez-Llorens, Xavier; Thompson, Herbert A; Dasch, Gregory A; Paddock, Christopher D; Zaki, Sherif; Eremeeva, Marina E

    2007-11-01

    We describe a fatal pediatric case of Rocky Mountain spotted fever in Panama, the first, to our knowledge, since the 1950s. Diagnosis was established by immunohistochemistry, PCR, and isolation of Rickettsia rickettsii from postmortem tissues. Molecular typing demonstrated strong relatedness of the isolate to strains of R. rickettsii from Central and South America.

  12. Proceedings of the 1989 ADAM Workshop

    NASA Astrophysics Data System (ADS)

    Chipperfield, Alan

    ADAM is now a major software project; it provides a fully integrated environment for both data reduction and data acquisition. It is being used in Hawaii, Australia and the Canary Islands, as well as the UK, and has been adopted by Starlink as the environment in which Starlink data reduction software should run. One of the most remarkable things about ADAM is that it has been developed as a co-operative effort between groups that are spread across the world. Although the initial system came out of RGO, and ROE provided by far the major effort in designing and implementing the VAX version, various parts of what is now regarded as 'ADAM' have also come from other establishments. Co-ordinating a project being developed in this way is not an easy job, but the somewhat varied parentage of ADAM - although sometimes an administrative nightmare - is also one of its strengths; it is not a system developed in one place to serve the specific needs of that one place. One way in which this development is co-ordinated is by a series of workshops. These have taken place at about 18 month intervals since the first one in late 1985. The workshops are attended by people actively developing and/or making extensive use of ADAM, and provide a forum for detailed discussion of the problems in the current system and plans for its extension. The 1989 ADAM Workshop was held at Cosener's House, Abingdon from 3rd to 7th July 1989. An 'Open Meeting' was held on Friday 30th June at RAL to enable members of the Starlink community to provide input to the Workshop discussions. Before the previous workshop, in Hawaii, a trend had started to emerge for different establishments to plug the gaps in ADAM (which at the time was missing a number of important facilities) with local solutions. The Hawaii Workshop consolidated these local extensions, adopting some and rejecting others. As a result, ADAM, as reviewed by this third workshop, was a much more complete and uniform system, and it was possible to

  13. The ADAM workshops and meeting summary

    NASA Astrophysics Data System (ADS)

    Chipperfield, Alan J.

    1990-01-01

    ADAM is now a major software project; it provides a fully integrated environment for both data reduction and data acquisition. It is being used in Hawaii, Australia and the Canary Islands, as well as the UK, and has been adopted by Starlink as the environment in which Starlink data reduction software should run. One of the most remarkable things about ADAM is that it has been developed as a co-operative effort between groups that are spread across the world. Although the initial system came out of RGO, and ROE provided by far the major effort in designing and implementing the VAX version, various parts of what is now regarded as 'ADAM' have also come from other establishments. Co-ordinating a project being developed in this way is not an easy job, but the somewhat varied parentage of ADAM - although sometimes an administrative nightmare - is also one of its strengths; it is not a system developed in one place to serve the specific needs of that one place. One way in which this development is co-ordinated is by a series of workshops. These have taken place at about 18 month intervals since the first one in late 1985. The workshops are attended by people actively developing and/or making extensive use of ADAM, and provide a forum for detailed discussion of the problems in the current system and plans for its extension. The 1989 ADAM Workshop was held at Cosener's House, Abingdon from 3rd to 7th July 1989. An 'Open Meeting' was held on Friday 30th June at RAL to enable members of the Starlink community to provide input to the Workshop discussions. Before the previous workshop, in Hawaii, a trend had started to emerge for different establishments to plug the gaps in ADAM (which at the time was missing a number of important facilities) with local solutions. The Hawaii Workshop consolidated these local extensions, adopting some and rejecting others. As a result, ADAM, as reviewed by this third workshop, was a much more complete and uniform system, and it was possible to

  14. The Role of ADAM9 in Tumor-Stromal Interactions in Breast Cancer

    DTIC Science & Technology

    2010-04-01

    ADAM family members in cancer. ADAM12 is expressed in carcinoma and promotes breast cancer progression by inducing the apoptosis of surrounding...stromal cells (13). Consequently, ADAM12 protein levels correlate with advanced breast cancer (14, 15). In contrast, the disintegrin domain of ADAM15...subgroup of ADAMs that also contains ADAM12 and ADAM15 (18). The ADAM9 metalloprotease activity cleaves heparin-binding epidermal growth factor (HB

  15. [Relationships between landscape structure and rocky desertification in karst region of northwestern Guangxi].

    PubMed

    Zhang, Xiao-nan; Wang, Ke-lin; Chen, Hong-song; Zhang, Wei

    2008-11-01

    By using canonical correspondence analysis (CCA), sixteen landscape indices were adopted to quantitatively analyze the relationships between the landscape structure and rocky desertification in karst region of Huanjiang County, Guangxi Province. The results showed that the first and the second ordination axis of CCA were strongly correlated to the factors of average patch area, average dry land patch area, landscape shape index, and landscape aggregation index. The potential rocky desertification in the region was highly positively correlated with the average dry land patch area and the average fractal dimensions of dry land and shrub land, but negatively correlated with the patch numbers of dry land. Light rocky desertification had obvious positive correlations with the fractal dimension index, average fractal dimension of unused land, and patch numbers of shrub land; while moderate and strong rocky desertification had high positive correlations with the average unused land patch area but negative correlation with the average fractal dimension of shrub land. To some extent, rocky desertification degree might be represented by the values of landscape indices. The gradient variation in karst rocky desertification along landscape structure was clearly presented by the results of CCA.

  16. Women in History--Abigail Adams: Life, Accomplishments, and Ideas

    ERIC Educational Resources Information Center

    Kenan, Sharon K.

    2008-01-01

    This article profiles the life, accomplishments, and ideas of Abigail Adams. Born in 1944, Adams lacked a formal education, but she more than made up for that shortcoming with her love of reading, especially literature, and her interests in politics and events surrounding the young colonies. Adams was supportive of the advancement of women. She…

  17. Adam Smith, Religion, and Tuition Tax Credits.

    ERIC Educational Resources Information Center

    Alexander, Kern

    1983-01-01

    Examines tuition tax credit programs in framework of Adam Smith's ideas on the economic impact of established churches. Finds that tuition tax credits would amount to state expenditures to relieve the financial burden of parochial school parents and would allow churches to invest commercially to maintain their charitable functions. (JW)

  18. Adam Smith and the Rhetoric of Style.

    ERIC Educational Resources Information Center

    Moran, Michael G.

    Historians of rhetoric have generally accepted the view that Adam Smith rejected the principles of classical rhetoric. However, while there can be no doubt that Smith greatly truncated the five classical arts of rhetoric (invention, arrangement, style, memory, and delivery) by reducing his concerns largely to style and arrangement, he did not…

  19. Paraprofessional of the Year 2009: Tina Adams

    ERIC Educational Resources Information Center

    Berry, John N., III

    2009-01-01

    There is no doubt among the staff and managers at North Carolina State University (NCSU) Libraries, Raleigh, that advanced library technician Tina Adams deserves to be the winner of the "Library Journal's "Paraprofessional of the Year Award for 2009." "Certainly this library has never seen anyone like her before, not in my nine…

  20. Propagandist of the Revolution: Samuel Adams.

    ERIC Educational Resources Information Center

    Scanlon, Thomas M.

    This paper explores Samuel Adam's role as perhaps the most important propagandist of the American Revolution and his efforts to exploit Great Britain's mistakes and to engender in the American colonists a love of liberty and a fear that Great Britain, if not resisted, would replace that liberty with tyranny. Suggesting that the Revolutionary War…

  1. Possible Binary Lightcurve for 3145 Walter Adams

    NASA Astrophysics Data System (ADS)

    Owings, Larry E.; Warner, Brian D.; Pravec, Petr; Kusnirak, Peter

    2011-01-01

    Lightcurve observations have yielded period determinations for asteroid 3145 Walter Adams. A primary period of 2.7113 ± 0.0001 hr, amplitude of 0.10 ± 0.05, and a possible secondary period of about 17.4 hr. The estimated diameter ratio is D2/D1 = 0.22 ± 0.02.

  2. Increased expression of ADAM12 and ADAM17 genes in laser-capture microdissected breast cancers and correlations with clinical and pathological characteristics.

    PubMed

    Narita, Diana; Seclaman, Edward; Ursoniu, Sorin; Anghel, Andrei

    2012-02-01

    ADAMs (a desintegrin and metalloprotease) are transmembrane glycoproteins involved in cell growth, differentiation, motility, and respectively, tumor growth and progression. Our aim was to evaluate ADAM12 spliced variants (ADAM12L - long membrane-bound and ADAM12S - secreted-short variant) and ADAM17 genes expression in breast cancers and to correlate their level of expression with clinical and pathological characteristics. Expression of ADAMs was analyzed using quantitative reverse-transcription polymerase chain reaction in laser-capture microdissected specimens of breast cancers and corresponding non-neoplastic breast tissues from 92 patients. The proteins' expression was confirmed by immunohistochemistry. Significantly elevated amounts of ADAM12L, ADAM12S and ADAM17 transcripts were found in malignant breast cells compared with normal breast tissue and both ADAMs proteins showed moderate to strong immunoexpression in tumor cells and peritumoral fibroblasts. ADAM12L and ADAM12S expressions were correlated with age, younger patients having higher expression of ADAM12L and ADAM12S; ductal cancers had higher expression of ADAM12L compared with lobular types, whereas ADAM12S was higher expressed in lobular cancers; higher expressions were found for both ADAM12 and ADAM17 in HER2/neu positive and highly proliferative cancers. High-grade cancers showed significantly increased expression of ADAM17. Our study on laser-capture microdissected specimens confers motivation for future work on development of ADAM-selective inhibitors for treatment of breast cancers.

  3. Exosome release of ADAM15 and the functional implications of human macrophage-derived ADAM15 exosomes.

    PubMed

    Lee, Hee Doo; Koo, Bon-Hun; Kim, Yeon Hyang; Jeon, Ok-Hee; Kim, Doo-Sik

    2012-07-01

    A disintegrin and metalloproteinase 15 (ADAM15), the only ADAM protein containing an Arg-Gly-Asp (RGD) motif in its disintegrin-like domain, is a widely expressed membrane protein that is involved in tumor progression and suppression. However, the underlying mechanism of ADAM15-mediated tumor suppression is not clearly understood. This study demonstrates that ADAM15 is released as an exosomal component, and ADAM15 exosomes exert tumor suppressive activities. We found that exosomal ADAM15 release is stimulated by phorbol 12-myristate 13-acetate, a typical protein kinase C activator, in various tumor cell types, and this results in a corresponding decrease in plasma membrane-associated ADAM15. Exosomes rich in ADAM15 display enhanced binding affinity for integrin αvβ3 in an RGD-dependent manner and suppress vitronectin- and fibronectin-induced cell adhesion, growth, and migration, as well as in vivo tumor growth. Exosomal ADAM15 is released from human macrophages, and macrophage-derived ADAM15 exosomes have tumor inhibitory effects. This work suggests a primary role of ADAM15 for exosome-mediated tumor suppression, as well as functional significance of exosomal ADAM protein in antitumor immunity.

  4. Managing Rocky Mountain spotted fever.

    PubMed

    Minniear, Timothy D; Buckingham, Steven C

    2009-11-01

    Rocky Mountain spotted fever is caused by the tick-borne bacterium Rickettsia rickettsii. Symptoms range from moderate illness to severe illness, including cardiovascular compromise, coma and death. The disease is prevalent in most of the USA, especially during warmer months. The trademark presentation is fever and rash with a history of tick bite, although tick exposure is unappreciated in over a third of cases. Other signature symptoms include headache and abdominal pain. The antibiotic therapy of choice for R. rickettsii infection is doxycycline. Preventive measures for Rocky Mountain spotted fever and other tick-borne diseases include: wearing long-sleeved, light colored clothing; checking for tick attachment and removing attached ticks promptly; applying topical insect repellent; and treating clothing with permethrin.

  5. ADAM12 is expressed by astrocytes during experimental demyelination.

    PubMed

    Baertling, Fabian; Kokozidou, Maria; Pufe, Thomas; Clarner, Tim; Windoffer, Reinhard; Wruck, Christoph J; Brandenburg, Lars-Ove; Beyer, Cordian; Kipp, Markus

    2010-04-22

    A disintegrin and metalloproteinase (ADAM) 12 represents a member of a large family of similarly structured multi-domain proteins. In the central nervous system (CNS), ADAM12 has been suggested to play a role in brain development, glioblastoma cell proliferation, and in experimental autoimmune encephalomyelitis. Furthermore, ADAM12 was reported to be almost exclusively expressed by oligodendrocytes and could, therefore, be considered as suitable marker for this cell type. In the present study, we investigated ADAM12 expression in the healthy and pathologically altered murine CNS. As pathological paradigm, we used the cuprizone demyelination model in which myelin loss during multiple sclerosis is imitated. Besides APC(+) oligodendrocytes, SMI311(+) neurons and GFAP(+) astrocytes express ADAM12 in the adult mouse brain. ADAM12 expression was further analyzed in vitro. After the induction of demyelination, we observed that activated astrocytes are the main source of ADAM12 in brain regions affected by oligodendrocyte loss. Exposure of astrocytes in vitro to either lipopolysaccharides (LPS), tumor necrosis factor alpha (TNFalpha), glutamate, or hydrogen peroxide revealed a highly stimulus-specific regulation of ADAM12 expression which was not seen in microglial BV2 cells. It appears that LPS- and TNFalpha-induced ADAM12 expression is mediated via the classic NFkappaB pathway. In summary, we demonstrated that ADAM12 is not a suitable marker for oligodendrocytes. Our results further suggest that ADAM12 might be implicated in the course of distinct CNS diseases such as demyelinating disorders.

  6. Heparan sulfate regulates ADAM12 through a molecular switch mechanism.

    PubMed

    Sørensen, Hans Peter; Vivès, Romain R; Manetopoulos, Christina; Albrechtsen, Reidar; Lydolph, Magnus C; Jacobsen, Jonas; Couchman, John R; Wewer, Ulla M

    2008-11-14

    The disintegrin and metalloproteases (ADAMs) are emerging as therapeutic targets in human disease, but specific drug design is hampered by potential redundancy. Unlike other metzincins, ADAM prodomains remain bound to the mature enzyme to regulate activity. Here ADAM12, a protease that promotes tumor progression and chondrocyte proliferation in osteoarthritic cartilage, is shown to possess a prodomain/catalytic domain cationic molecular switch, regulated by exogenous heparan sulfate and heparin but also endogenous cell surface proteoglycans and the polyanion, calcium pentosan polysulfate. Sheddase functions of ADAM12 are regulated by the switch, as are proteolytic functions in placental tissue and sera of pregnant women. Moreover, human heparanase, an enzyme also linked to tumorigenesis, can promote ADAM12 sheddase activity at the cell surface through cleavage of the inhibitory heparan sulfate. These data present a novel concept that might allow targeting of ADAM12 and suggest that other ADAMs may have specific regulatory activity embedded in their prodomain and catalytic domain structures.

  7. HAER COLO,1COMCI,2A (sheet 1 of 2) Highline Canal, Sand ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    HAER COLO,1-COMCI,2A- (sheet 1 of 2) - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  8. 24. CULVERT WITH CONCRETE HEADWALL AND SIDEWALLS CARRYING THE LATERAL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    24. CULVERT WITH CONCRETE HEADWALL AND SIDEWALLS CARRYING THE LATERAL UNDER 8TH AVENUE. - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  9. 16. TWO HEAD GATES ABOUT 500 FEET NORTH OF 7TH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. TWO HEAD GATES ABOUT 500 FEET NORTH OF 7TH AVENUE (SECTION 35). - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  10. 14. DAMAGED HEAD GATE NORTH OF LAKE LADORA (SECTION 2). ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. DAMAGED HEAD GATE NORTH OF LAKE LADORA (SECTION 2). - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  11. HAER COLO,1COMCI,2A (sheet 2 of 2) Highline Canal, Sand ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    HAER COLO,1-COMCI,2A- (sheet 2 of 2) - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  12. 2. COURSE OF THE LATERAL THROUGH DEL NORTHWEST MAR PARK. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. COURSE OF THE LATERAL THROUGH DEL NORTHWEST MAR PARK. - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  13. 13. TREES ALONG LATERAL SEGMENT AT THE NORTHERN END OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. TREES ALONG LATERAL SEGMENT AT THE NORTHERN END OF LAKE LADORA. - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  14. 22. HEAD GATE IN THE NORTHEAST QUARTER OF SECTION 35; ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    22. HEAD GATE IN THE NORTHEAST QUARTER OF SECTION 35; NOTE CONTROL WHEEL. - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  15. 9. DETAIL OF DIVERSION STRUCTURE WEST OF DERBY LAKE (SECTION ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. DETAIL OF DIVERSION STRUCTURE WEST OF DERBY LAKE (SECTION 2) SHOWING DIVERSION GATE TO LAKE LADORA. - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  16. 23. OUTLET PIPE EMBEDDED IN CONCRETE FOR THE HEAD GATE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    23. OUTLET PIPE EMBEDDED IN CONCRETE FOR THE HEAD GATE SHOWN IN CO-43-A-22. - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  17. 8. GENERAL VIEW OF LARGE DIVERSION STRUCTURE ON LATERAL WEST ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. GENERAL VIEW OF LARGE DIVERSION STRUCTURE ON LATERAL WEST OF LOWER DERBY LAKE (SECTION 2). - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  18. 25. DIVERSION STRUCTURE EAST OF FORMER BASIN F IN SECTION ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    25. DIVERSION STRUCTURE EAST OF FORMER BASIN F IN SECTION 26. - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  19. 20. HEAD GATE IN THE NORTHWEST QUARTER OF SECTION 35. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    20. HEAD GATE IN THE NORTHWEST QUARTER OF SECTION 35. - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  20. 6. DROP STRUCTURE BETWEEN C AND D STREETS (SECTION 11). ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. DROP STRUCTURE BETWEEN C AND D STREETS (SECTION 11). - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  1. 5. HEAD GATE BETWEEN C AND D STREETS (SECTION 11). ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. HEAD GATE BETWEEN C AND D STREETS (SECTION 11). - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  2. 7. SEGMENT OF LATERAL WITH YUCCA ALONG BANKS, SOUTH OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. SEGMENT OF LATERAL WITH YUCCA ALONG BANKS, SOUTH OF 6TH AVENUE (SECTION 10). - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  3. 21. OUTLET PIPE AND CONCRETE CHANNEL FOR THE HEAD GATE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    21. OUTLET PIPE AND CONCRETE CHANNEL FOR THE HEAD GATE PICTURED IN CO-43-A-20. - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  4. 17. DETAIL OF ONE OF THE HEAD GATES PICTURED IN ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    17. DETAIL OF ONE OF THE HEAD GATES PICTURED IN CO-43-A-16 (SECTION 35). - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  5. 3. 1939 DROP STRUCTURE IN DEL MAR PARK SURMOUNTED BY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. 1939 DROP STRUCTURE IN DEL MAR PARK SURMOUNTED BY RECENT PEDESTRIAN BRIDGE. - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  6. 26. DIVERSION STRUCTURE WITH FORMER BASIN F IN DISTANCE (SECTION ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    26. DIVERSION STRUCTURE WITH FORMER BASIN F IN DISTANCE (SECTION 26). - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  7. Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  8. Targeting autocrine HB-EGF signaling with specific ADAM12 inhibition using recombinant ADAM12 prodomain

    PubMed Central

    Miller, Miles A.; Moss, Marcia L.; Powell, Gary; Petrovich, Robert; Edwards, Lori; Meyer, Aaron S.; Griffith, Linda G.; Lauffenburger, Douglas A.

    2015-01-01

    Dysregulation of ErbB-family signaling underlies numerous pathologies and has been therapeutically targeted through inhibiting ErbB-receptors themselves or their cognate ligands. For the latter, “decoy” antibodies have been developed to sequester ligands including heparin-binding epidermal growth factor (HB-EGF); however, demonstrating sufficient efficacy has been difficult. Here, we hypothesized that this strategy depends on properties such as ligand-receptor binding affinity, which varies widely across the known ErbB-family ligands. Guided by computational modeling, we found that high-affinity ligands such as HB-EGF are more difficult to target with decoy antibodies compared to low-affinity ligands such as amphiregulin (AREG). To address this issue, we developed an alternative method for inhibiting HB-EGF activity by targeting its cleavage from the cell surface. In a model of the invasive disease endometriosis, we identified A Disintegrin and Metalloproteinase 12 (ADAM12) as a protease implicated in HB-EGF shedding. We designed a specific inhibitor of ADAM12 based on its recombinant prodomain (PA12), which selectively inhibits ADAM12 but not ADAM10 or ADAM17. In endometriotic cells, PA12 significantly reduced HB-EGF shedding and resultant cellular migration. Overall, specific inhibition of ligand shedding represents a possible alternative to decoy antibodies, especially for ligands such as HB-EGF that exhibit high binding affinity and localized signaling. PMID:26477568

  9. Targeting autocrine HB-EGF signaling with specific ADAM12 inhibition using recombinant ADAM12 prodomain.

    PubMed

    Miller, Miles A; Moss, Marcia L; Powell, Gary; Petrovich, Robert; Edwards, Lori; Meyer, Aaron S; Griffith, Linda G; Lauffenburger, Douglas A

    2015-10-19

    Dysregulation of ErbB-family signaling underlies numerous pathologies and has been therapeutically targeted through inhibiting ErbB-receptors themselves or their cognate ligands. For the latter, "decoy" antibodies have been developed to sequester ligands including heparin-binding epidermal growth factor (HB-EGF); however, demonstrating sufficient efficacy has been difficult. Here, we hypothesized that this strategy depends on properties such as ligand-receptor binding affinity, which varies widely across the known ErbB-family ligands. Guided by computational modeling, we found that high-affinity ligands such as HB-EGF are more difficult to target with decoy antibodies compared to low-affinity ligands such as amphiregulin (AREG). To address this issue, we developed an alternative method for inhibiting HB-EGF activity by targeting its cleavage from the cell surface. In a model of the invasive disease endometriosis, we identified A Disintegrin and Metalloproteinase 12 (ADAM12) as a protease implicated in HB-EGF shedding. We designed a specific inhibitor of ADAM12 based on its recombinant prodomain (PA12), which selectively inhibits ADAM12 but not ADAM10 or ADAM17. In endometriotic cells, PA12 significantly reduced HB-EGF shedding and resultant cellular migration. Overall, specific inhibition of ligand shedding represents a possible alternative to decoy antibodies, especially for ligands such as HB-EGF that exhibit high binding affinity and localized signaling.

  10. Targeting autocrine HB-EGF signaling with specific ADAM12 inhibition using recombinant ADAM12 prodomain

    NASA Astrophysics Data System (ADS)

    Miller, Miles A.; Moss, Marcia L.; Powell, Gary; Petrovich, Robert; Edwards, Lori; Meyer, Aaron S.; Griffith, Linda G.; Lauffenburger, Douglas A.

    2015-10-01

    Dysregulation of ErbB-family signaling underlies numerous pathologies and has been therapeutically targeted through inhibiting ErbB-receptors themselves or their cognate ligands. For the latter, “decoy” antibodies have been developed to sequester ligands including heparin-binding epidermal growth factor (HB-EGF); however, demonstrating sufficient efficacy has been difficult. Here, we hypothesized that this strategy depends on properties such as ligand-receptor binding affinity, which varies widely across the known ErbB-family ligands. Guided by computational modeling, we found that high-affinity ligands such as HB-EGF are more difficult to target with decoy antibodies compared to low-affinity ligands such as amphiregulin (AREG). To address this issue, we developed an alternative method for inhibiting HB-EGF activity by targeting its cleavage from the cell surface. In a model of the invasive disease endometriosis, we identified A Disintegrin and Metalloproteinase 12 (ADAM12) as a protease implicated in HB-EGF shedding. We designed a specific inhibitor of ADAM12 based on its recombinant prodomain (PA12), which selectively inhibits ADAM12 but not ADAM10 or ADAM17. In endometriotic cells, PA12 significantly reduced HB-EGF shedding and resultant cellular migration. Overall, specific inhibition of ligand shedding represents a possible alternative to decoy antibodies, especially for ligands such as HB-EGF that exhibit high binding affinity and localized signaling.

  11. Cellular roles of ADAM12 in health and disease.

    PubMed

    Kveiborg, Marie; Albrechtsen, Reidar; Couchman, John R; Wewer, Ulla M

    2008-01-01

    ADAM12 belongs to the large family of ADAMs (a disintegrin and metalloproteases) and possesses extracellular metalloprotease and cell-binding functions, as well as intracellular signaling capacities. Interest in ADAM12 has increased recently because its expression is related to tumor progression and it is a potential biomarker for breast cancer. It is therefore important to understand ADAM12's functions. Many cellular roles for ADAM12 have been suggested. It is an active metalloprotease, and has been implicated in insulin-like growth factor (IGF) receptor signaling, through cleavage of IGF-binding proteins, and in epidermal growth factor receptor (EGFR) pathways, via ectodomain shedding of membrane-tethered EGFR ligands. These proteolytic events may regulate diverse cellular responses, such as altered cell differentiation, proliferation, migration, and invasion. ADAM12 may also regulate cell-cell and cell-extracellular matrix contacts through interactions with cell surface receptors - integrins and syndecans - potentially influencing the actin cytoskeleton. Moreover, ADAM12 interacts with several cytoplasmic signaling and adaptor molecules through its intracellular domain, thereby directly transmitting signals to or from the cell interior. These ADAM12-mediated cellular effects appear to be critical events in both biological and pathological processes. This review presents current knowledge on ADAM12 functions gained from in vitro and in vivo observations, describes ADAM12's role in both normal physiology and pathology, particularly in cancer, and discusses important areas for future investigation.

  12. Targeting ADAM12 in human disease: head, body or tail?

    PubMed

    Jacobsen, J; Wewer, U M

    2009-01-01

    ADAM12/meltrin alpha is a type I transmembrane multidomain protein involved in tumor progression and other severe diseases, including osteoarthritis, and as such could be considered as a potential drug target. In addition to protease activity, ADAM12 possesses cell binding and cell signaling properties. This functional trinity is reflected in the structure of ADAM12, which can be divided into head, body, and tail. The head of the protein (consisting of the pro and catalytic domains) mediates processing of growth factors and cytokines and has been implicated in epidermal growth factor (EGF) and insulin-like growth factor receptor signaling. The body of the protein (consisting of the disintegrin, cysteine-rich, and EGF-like domains) is involved in contacts with the extracellular matrix and other cells through interactions with integrins and syndecans. Finally, the tail of the protein (consisting of the cytoplasmic domain) is engaged in interactions with intracellular signaling molecules. In many studies, ADAM12 overexpression has been correlated with disease, and ADAM12 has been shown to promote tumor growth and progression in cancer. On the other hand, protective effects of ADAM12 in disease have also been reported. Future investigations should address the precise mechanisms of ADAM12 in disease and biology in order to counterbalance the benefits from targeting ADAM12 therapeutically with possible side effects. This review describes the biology of ADAM12, its association with disease, and evaluates the possible approaches to targeting ADAM12 in human disease.

  13. Iterative Mechanism Solutions with Scenario and ADAMS

    NASA Technical Reports Server (NTRS)

    Rhoades, Daren

    2006-01-01

    This slide presentation reviews the use of iterative solutions using Scenario for Motion (UG NX 2 Motion) to assist in designing the Mars Science Laboratory (MSL). The MSL will have very unique design requirements, and in order to meet these requirements the system must have the ability to design for static stability, simulate mechanism kinematics, simulate dynamic behaviour and be capable of reconfiguration, and iterations as designed. The legacy process used on the Mars Exploration rovers worked, but it was cumbersome using multiple tools, limited configuration control, with manual process and communication, and multiple steps. The aim is to develop a mechanism that would reduce turn around time, and make more reiterations possible, to improve the quality and quantity of data, and to enhance configuration control. Currently for NX Scenario for Motion uses are in the articulation studies, the simulations of traverse motions,and subsystem simulations. The design of the Rover landing model requires accurate results, flexible elements, such as beams, and the use of the full ADAMS solver has been used. In order to achieve this, when required, there has been a direct translation from Scenario to ADAMS, with additional data in ascii format. The process that has been designed to move from Scenario to ADAMS is reviewed.

  14. Catalytic properties of ADAM12 and its domain deletion mutants.

    PubMed

    Jacobsen, Jonas; Visse, Robert; Sørensen, Hans Peter; Enghild, Jan J; Brew, Keith; Wewer, Ulla M; Nagase, Hideaki

    2008-01-15

    Human ADAM12 (a disintegrin and metalloproteinase) is a multidomain zinc metalloproteinase expressed at high levels during development and in human tumors. ADAM12 exists as two splice variants: a classical type 1 membrane-anchored form (ADAM12-L) and a secreted splice variant (ADAM12-S) consisting of pro, catalytic, disintegrin, cysteine-rich, and EGF domains. Here we present a novel activity of recombinant ADAM12-S and its domain deletion mutants on S-carboxymethylated transferrin (Cm-Tf). Cleavage of Cm-Tf occurred at multiple sites, and N-terminal sequencing showed that the enzyme exhibits restricted specificity but a consensus sequence could not be defined as its subsite requirements are promiscuous. Kinetic analysis revealed that the noncatalytic C-terminal domains are important regulators of Cm-Tf activity and that ADAM12-PC consisting of the pro domain and catalytic domain is the most active on this substrate. It was also observed that NaCl inhibits ADAM12. Among the tissue inhibitors of metalloproteinases (TIMP) examined, the N-terminal domain of TIMP-3 (N-TIMP-3) inhibits ADAM12-S and ADAM12-PC with low nanomolar Ki(app) values while TIMP-2 inhibits them with a slightly lower affinity (9-44 nM). However, TIMP-1 is a much weaker inhibitor. N-TIMP-3 variants that lack MMP inhibitory activity but retained the ability to inhibit ADAM17/TACE failed to inhibit ADAM12. These results indicate unique enzymatic properties of ADAM12 among the members of the ADAM family of metalloproteinases.

  15. Internal architecture of the proximal femur--Adam's or Adams' arch? Historical mystery.

    PubMed

    Bartonícek, J

    2002-12-01

    The designation 'Adam Bogen' describing the thick medial cortex of the femoral neck is an incorrect term. This arch was described by Robert Adams (1795-1871), an outstanding Irish anatomist and surgeon. He was famous mainly for his book on gout and the description of disorders of cardiac rhythm, the so-called Adams-Stokes syndrome. He published his original description in the today unfortunately almost forgotten Cyclopaedia of Anatomy and Physiology, Vol. II (London, Longman, 1836-1839). The main editor of this monumental six-volume work was the famous anatomist and surgeon R.B.Todd. This book represents a significant source of information on diseases and injuries of the great joints (shoulder, elbow, wrist, knee, ankle).

  16. Shedding of Collagen XVII/BP180 in Skin Depends on Both ADAM10 and ADAM9*

    PubMed Central

    Franzke, Claus-Werner; Bruckner-Tuderman, Leena; Blobel, Carl P.

    2009-01-01

    Collagen XVII is a transmembrane collagen and the major autoantigen of the autoimmune skin blistering disease bullous pemphigoid. Collagen XVII is proteolytically released from the membrane, and the pathogenic epitope harbors the cleavage site for its ectodomain shedding, suggesting that proteolysis has an important role in regulating the function of collagen XVII in skin homeostasis. Previous studies identified ADAMs 9, 10, and 17 as candidate collagen XVII sheddases and suggested that ADAM17 is a major sheddase. Here we show that ADAM17 only indirectly affects collagen XVII shedding and that ADAMs 9 and 10 are the most prominent collagen XVII sheddases in primary keratinocytes because (a) collagen XVII shedding was not stimulated by phorbol esters, known activators of ADAM17, (b) constitutive and calcium influx-stimulated shedding was sensitive to the ADAM10-selective inhibitor GI254023X and was strongly reduced in Adam10−/− cells, (c) there was a 55% decrease in constitutive collagen XVII ectodomain shedding from Adam9−/− keratinocytes, and (d) H2O2 enhanced ADAM9 expression and stimulated collagen XVII shedding in skin and keratinocytes of wild type mice but not of Adam9−/− mice. We conclude that ADAM9 and ADAM10 can both contribute to collagen XVII shedding in skin with an enhanced relative contribution of ADAM9 in the presence of reactive oxygen species. These results provide critical new insights into the identity and regulation of the major sheddases for collagen XVII in keratinocytes and skin and have implications for the treatment of blistering diseases of the skin. PMID:19574220

  17. Shedding of collagen XVII/BP180 in skin depends on both ADAM10 and ADAM9.

    PubMed

    Franzke, Claus-Werner; Bruckner-Tuderman, Leena; Blobel, Carl P

    2009-08-28

    Collagen XVII is a transmembrane collagen and the major autoantigen of the autoimmune skin blistering disease bullous pemphigoid. Collagen XVII is proteolytically released from the membrane, and the pathogenic epitope harbors the cleavage site for its ectodomain shedding, suggesting that proteolysis has an important role in regulating the function of collagen XVII in skin homeostasis. Previous studies identified ADAMs 9, 10, and 17 as candidate collagen XVII sheddases and suggested that ADAM17 is a major sheddase. Here we show that ADAM17 only indirectly affects collagen XVII shedding and that ADAMs 9 and 10 are the most prominent collagen XVII sheddases in primary keratinocytes because (a) collagen XVII shedding was not stimulated by phorbol esters, known activators of ADAM17, (b) constitutive and calcium influx-stimulated shedding was sensitive to the ADAM10-selective inhibitor GI254023X and was strongly reduced in Adam10(-/-) cells, (c) there was a 55% decrease in constitutive collagen XVII ectodomain shedding from Adam9(-/-) keratinocytes, and (d) H(2)O(2) enhanced ADAM9 expression and stimulated collagen XVII shedding in skin and keratinocytes of wild type mice but not of Adam9(-/-) mice. We conclude that ADAM9 and ADAM10 can both contribute to collagen XVII shedding in skin with an enhanced relative contribution of ADAM9 in the presence of reactive oxygen species. These results provide critical new insights into the identity and regulation of the major sheddases for collagen XVII in keratinocytes and skin and have implications for the treatment of blistering diseases of the skin.

  18. Adam12 plays a role during uterine decidualization in mice.

    PubMed

    Zhang, Li; Guo, Weixiang; Chen, Qi; Fan, Xiujun; Zhang, Ying; Duan, Enkui

    2009-12-01

    In mouse, decidualization is characterized by the proliferation of stromal cells and their differentiation into specialized type of cells (decidual cells) with polyploidy, surrounding the implanting blastocyst. However, the mechanisms involved in these processes remain poorly understood. Using multiple approaches, we have examined the role of Adam12 in decidualization during early pregnancy in mice. Adam12 is spatiotemporally expressed in decidualizing stromal cells in intact pregnant females and in pseudopregnant mice undergoing artificially induced decidualization. In the ovariectomized mouse uterus, the expression of Adam12 is upregulated after progesterone treatment, which is primarily mediated by nuclear progesterone receptor. In a stromal cell culture model, the expression of Adam12 gradually rises with the progression of stromal decidualization, whereas the attenuated expression of Adam12 after siRNA knockdown significantly blocks the progression of decidualization. Our study suggests that Adam12 is involved in promoting uterine decidualization during pregnancy.

  19. 27 CFR 9.43 - Rocky Knob.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ....S.G.S. maps. The maps are entitled: “Willis Quadrangle Virginia” 7.5 minute series and “Woolwine Quadrangle Virginia” 7.5 minute series. (c) Boundaries. The Rocky Knob viticultural area is located in Floyd... Route No. 726 at the southern boundary of the Rocky Knob Recreation Area. (5) Then follow the...

  20. 27 CFR 9.43 - Rocky Knob.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2014-04-01 2014-04-01 false Rocky Knob. 9.43 Section 9.43 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL AMERICAN VITICULTURAL AREAS Approved American Viticultural Areas § 9.43 Rocky Knob....

  1. 27 CFR 9.43 - Rocky Knob.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Rocky Knob. 9.43 Section 9.43 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS AMERICAN VITICULTURAL AREAS Approved American Viticultural Areas § 9.43 Rocky Knob....

  2. Rocky Mountain spotted fever in children.

    PubMed

    Woods, Charles R

    2013-04-01

    Rocky Mountain spotted fever is typically undifferentiated from many other infections in the first few days of illness. Treatment should not be delayed pending confirmation of infection when Rocky Mountain spotted fever is suspected. Doxycycline is the drug of choice even for infants and children less than 8 years old.

  3. Rocky Mountain Spotted Fever: Statistics and Epidemiology

    MedlinePlus

    ... Search The CDC Cancel Submit Search The CDC Rocky Mountain Spotted Fever (RMSF) Note: Javascript is disabled or is not ... message, please visit this page: About CDC.gov . Rocky Mountain Spotted Fever (RMSF) Symptoms, Diagnosis, and Treatment Statistics and Epidemiology ...

  4. ADAM10: a new player in breast cancer progression?

    PubMed Central

    Mullooly, Maeve; McGowan, Patricia M; Kennedy, Susan A; Madden, Stephen F; Crown, John; O' Donovan, Norma; Duffy, Michael J

    2015-01-01

    Background: The ADAM proteases are best known for their role in shedding the extracellular domain of transmembrane proteins. Among the transmembrane proteins shed by ADAM10 are notch, HER2, E-cadherin, CD44, L1 and the EGFR ligands, EGF and betacellulin. As cleavage of several of these proteins has been implicated in cancer formation and progression, we hypothesised that ADAM10 is also involved in these processes. Methods: ADAM10 expression was decreased by RNA interference and the effects of this on cell numbers, invasion and migration were determined. We also examined the effect of ADAM10 inhibition on breast cancer cell line invasion and migration. Results: Using the triple-negative (TN) breast cancer cell lines, BT20, MDA-MB-231 and the non-TN cell line MDA-MB-453, knockdown of ADAM10 expression significantly decreased in vitro migration (P<0.01; for each cell line). Similarly, treatment with the ADAM10-selective inhibitor GI254023X reduced migration in the three cell lines (for BT20, P<0.001; for MDA-MB-231, P=0.005; for MDA-MB-453, P=0.023). In contrast, neither knockdown of ADAM10 nor treatment with the ADAM10-selective inhibitor GI254023X significantly affected cell numbers. Using extracts of primary breast cancers, higher levels of ADAM10 were found more frequently in high-grade vs low-grade tumours (P<0.001) and in oestrogen receptor (ER)-negative compared with ER-positive tumours (P=0.005). Analysis of pooled publicly available data sets found that high levels of ADAM10 mRNA were associated with adverse outcome in patients with the basal subtype of breast cancer. Conclusions: Based on our combined cell line and breast cancer extract data, we conclude that ADAM10 is likely to be involved in breast cancer progression, especially in the basal subtype. PMID:26284334

  5. Closing Rocky Flats by 2006

    SciTech Connect

    Tuor, N. R.; Schubert, A. L.

    2002-02-26

    Safely accelerating the closure of Rocky Flats to 2006 is a goal shared by many: the State of Colorado, the communities surrounding the site, the U.S. Congress, the Department of Energy, Kaiser-Hill and its team of subcontractors, the site's employees, and taxpayers across the country. On June 30, 2000, Kaiser-Hill (KH) submitted to the Department of Energy (DOE), KH's plan to achieve closure of Rocky Flats by December 15, 2006, for a remaining cost of $3.96 billion (February 1, 2000, to December 15, 2006). The Closure Project Baseline (CPB) is the detailed project plan for accomplishing this ambitious closure goal. This paper will provide a status report on the progress being made toward the closure goal. This paper will: provide a summary of the closure contract completion criteria; give the current cost and schedule variance of the project and the status of key activities; detail important accomplishments of the past year; and discuss the challenges ahead.

  6. ADAM Proteases: Ligand Processing and Modulation of the Notch Pathway

    PubMed Central

    Zolkiewska, Anna

    2009-01-01

    ADAM metalloproteases play important roles in development and disease. One of the key functions of ADAMs is the proteolytic processing of Notch receptors and their ligands. ADAM-mediated cleavage of Notch represents the first step of the regulated intramembrane proteolysis of the receptor, leading to activation of the Notch pathway. Recent reports indicate that the transmembrane Notch ligands also undergo ADAM-mediated processing in cultured cells and in vivo. The proteolytic processing of Notch ligands modulates the strength and duration of Notch signals, leads to generation of soluble intracellular domains of the ligands, and may support a bi-directional signaling between cells. PMID:18344021

  7. Rockies

    Atmospheric Science Data Center

    2014-05-15

    ... orbit 7447) include portions of southern Wyoming, central Colorado, and western Nebraska. The top view is from the instrument's ... 422 kilometers x 213 kilometers. The South Platte River enters just to the right of center at the top of the images. It winds its ...

  8. Rocky Mountain Snowpack Physical and Chemical Data for Selected Sites, 1993-2008

    USGS Publications Warehouse

    Ingersoll, George P.; Mast, M. Alisa; Campbell, Donald H.; Clow, David W.; Nanus, Leora; Turk, John T.

    2009-01-01

    The Rocky Mountain Snowpack program established a network of snowpack-sampling sites in the Rocky Mountain region from New Mexico to Montana to monitor the chemical content of snow to help in the understanding of the effects of atmospheric deposition to this region. The U.S. Geological Survey, in cooperation with the National Park Service, the USDA Forest Service, Teton County in Wyoming, Rio Blanco County in Colorado, Pitkin County in Colorado, and others, collected and analyzed snowpack samples annually for 48 or more sites in the Rocky Mountain region during 1993-2008. Forty-eight of the 162 snow-sampling sites have been sampled annually since 1993. Data include acid-neutralization capacity, specific conductance, pH, hydrogen ion concentrations, dissolved concentrations of major constituents (calcium, magnesium, sodium, potassium, ammonium, chloride, sulfate, and nitrate), dissolved organic carbon concentrations, snow/ water equivalent, snow depth, stable sulfur isotope ratios, total mercury concentrations (beginning in 2001), and ionic charge balance. Quality-assurance data for field and laboratory blanks and field replicates for individual years (1993-2008) also are included.

  9. From Adam Swift to Adam Smith: How the "Invisible Hand" Overcomes Middle Class Hypocrisy

    ERIC Educational Resources Information Center

    Tooley, James

    2007-01-01

    This paper challenges Richard Pring's suggestion that parents using private education may be undermining the desire for social justice and equality, using recent arguments of Adam Swift as a springboard. Swift's position on the banning of private schools, which uses a Rawlsian "veil of ignorance" argument, is explored, and it is suggested that, if…

  10. Connective tissue growth factor is a substrate of ADAM28

    SciTech Connect

    Mochizuki, Satsuki; Tanaka, Rena; Shimoda, Masayuki; Onuma, Junko; Fujii, Yutaka; Jinno, Hiromitsu; Okada, Yasunori

    2010-11-26

    Research highlights: {yields} The hyper-variable region in the cysteine-rich domain of ADAM28 binds to C-terminal domain of CTGF. {yields} ADAM28 cleaves CTGF alone and CTGF in the CTGF/VEGF{sub 165} complex. {yields} CTGF digestion by ADAM28 releases biologically active VEGF{sub 165} from the complex. {yields} ADAM28, CTGF and VEGF{sub 165} are commonly co-expressed by carcinoma cells in human breast carcinoma tissues. {yields} These suggest that ADAM28 promotes VEGF{sub 165}-induced angiogenesis in the breast carcinomas by selective CTGF digestion in the CTGF/VEGF{sub 165} complex. -- Abstract: ADAM28, a member of the ADAM (a disintegrin and metalloproteinase) gene family, is over-expressed by carcinoma cells and the expression correlates with carcinoma cell proliferation and progression in human lung and breast carcinomas. However, information about substrates of ADAM28 is limited. We screened interacting molecules of ADAM28 in human lung cDNA library by yeast two-hybrid system and identified connective tissue growth factor (CTGF). Binding of CTGF to proADAM28 was demonstrated by yeast two-hybrid assay and protein binding assay. ADAM28 cleaved CTGF in dose- and time-dependent manners at the Ala{sup 181}-Tyr{sup 182} and Asp{sup 191}-Pro{sup 192} bonds in the hinge region of the molecule. ADAM28 selectively digested CTGF in the complex of CTGF and vascular endothelial growth factor{sub 165} (VEGF{sub 165}), releasing biologically active VEGF{sub 165} from the complex. RT-PCR and immunohistochemical analyses demonstrated that ADAM28, CTGF and VEGF are commonly co-expressed in the breast carcinoma tissues. These data provide the first evidence that CTGF is a novel substrate of ADAM28 and suggest that ADAM28 may promote VEGF{sub 165}-induced angiogenesis in the breast carcinomas by the CTGF digestion in the CTGF/VEGF{sub 165} complex.

  11. Fatal Rocky Mountain spotted fever.

    PubMed

    Hattwick, M A; Retailliau, H; O'Brien, R J; Slutzker, M; Fontaine, R E; Hanson, B

    1978-09-29

    Forty-four fatal cases of Rocky Mountain spotted fever (RMSF) occurring in 1974 were compared with 50 nonfatal cases of similar age, sex, date of onset, and place of occurrence. Diagnosis and initiation of treatment in fatal cases were substantially delayed compared with nonfatal cases. Several reasons for this delay were identified: (1) the rash appeared later in the course of illness in the fatal cases, often not until the patient was terminal, (2) a history of tick bite was less often obtained during life or obtained late in the clinical course in fatal cases, and (3) initial nonspecific symptoms or unexpected symptoms led to an initial diagnosis of more common diseases. Only two fatal cases were treated with either tetracycline or chloramphenicol before the sixth day of illness. Presumptive diagnosis of RMSF and initiation of tetracycline therapy before onset of rash may be necessary to reduce mortality.

  12. ADAM12 and ADAM17 gene expression in laser-capture microdissected and non-microdissected breast tumors.

    PubMed

    Narita, Diana; Seclaman, Edward; Ilina, Razvan; Cireap, Natalia; Ursoniu, Sorin; Anghel, Andrei

    2011-06-01

    ADAM (a disintegrin and metalloprotease)12 and ADAM17 are multidomain transmembrane proteins involved in ectodomain shedding of cytokines, growth factors and adhesion molecules, with pivotal activities in the tumor microenvironment. The aim of this study was to confirm the up-regulation of ADAM17 and ADAM12 gene splicing variants in breast tumors and to delineate their expression between laser-capture microdissected (LCM) and non-microdissected breast tumors. The gene expression was analyzed by quantitative-reverse transcription-PCR in a total sample of 109 breast tumors paired with corresponding non-neoplastic breast tissues. ADAM12 and 17 proteins expression for corresponding tissue samples was confirmed by immunohistochemistry. ADAM12S, 12L and 17 genes were significantly up-regulated in either malign or benign LCM samples when compared to non-tumor controls. For non-LCM samples, it was obtained also an increased expression for ADAM12 and 17 genes in cancers, while in benign tumors only ADAM12 variants were significantly up-regulated compared to controls. When benign versus malignant tumors were compared, in LCM samples all investigated genes displayed a higher expression in cancers, whereas in non-LCM, ADAM12 variants were overexpressed in benign samples. The increased expression of ADAM12 protein in the tumor cells and stroma of benign breast diseases was immunohistochemically confirmed. These differences between LCM and non-LCM samples were explained by the contribution of the stroma to the expression of this marker. This study underlines the accuracy conferred by homogenous LCM samples on gene expression profiles and confers further evidence regarding the role of ADAM12 and 17 in the breast tumorigenesis and progression.

  13. ADAM8 as a drug target in Pancreatic Cancer

    PubMed Central

    Schlomann, Uwe; Koller, Garrit; Conrad, Catharina; Ferdous, Taheera; Golfi, Panagiota; Garcia, Adolfo Molejon; Höfling, Sabrina; Parsons, Maddy; Costa, Patricia; Soper, Robin; Bossard, Maud; Hagemann, Thorsten; Roshani, Rozita; Sewald, Norbert; Ketchem, Randal R.; Moss, Marcia L.; Rasmussen, Fred H.; Miller, Miles A.; Lauffenburger, Douglas A.; Tuveson, David A.; Nimsky, Christopher; Bartsch, Jörg W.

    2016-01-01

    Pancreatic ductal adenocarcinoma (PDAC) has a grim prognosis with less than 5% survivors after 5 years. High expression levels of ADAM8, a metalloprotease-disintegrin, are correlated with poor clinical outcome. We show that ADAM8 expression is associated with increased migration and invasiveness of PDAC cells caused by activation of ERK 1/2 and higher MMP activities. For biological function, ADAM8 requires multimerisation and associates with β1-integrin on the cell surface. A peptidomimetic ADAM8 inhibitor, BK-1361, designed by structural modelling of the disintegrin domain, prevents ADAM8 multimerisation. In PDAC cells, BK-1361 affects ADAM8 function leading to reduced invasiveness, and less ERK 1/2 and MMP activation. BK-1361 application in mice decreased tumour burden and metastasis of implanted pancreatic tumour cells and provides improved metrics of clinical symptoms and survival in a KrasG12D-driven mouse model of PDAC. Thus, our data integrate ADAM8 in pancreatic cancer signalling and validate ADAM8 as a target for PDAC therapy. PMID:25629724

  14. The Failed Educations of John Stuart Mill and Henry Adams.

    ERIC Educational Resources Information Center

    Crossley, Robert

    1979-01-01

    Analyzes and contrasts Mill's "Autobiography" and Adams'"The Education of Henry Adams" in order to present two approaches to the nature of education and of failure. Maintains that their perspectives may serve as catalysts and cautions for contemporary theories of education and its utility and relevance. (CAM)

  15. Molecular profiling of ADAM12 gene in breast cancers.

    PubMed

    Nariţa, Diana; Anghel, A; Seclaman, E; Ilina, R; Cireap, Natalia; Ursoniu, S

    2010-01-01

    ADAMs (a disintegrin and metalloproteinase) family have been associated with the process of proteolytic "shedding" of membrane-associated proteins ectodomain and hence the rapid modulation of key cell signaling pathways in tissues microenvironment. A variety of cytokines, chemokines and growth factors which are initially produced as transmembrane proforms are activated by these sheddase activities. ADAM12 is highly expressed in rapidly growing tissues such as placenta and malignant tumors and it was found as one of the Candidate Cancer Genes in a comprehensive mutational analysis of human breast cancers. Our aim was to determine the gene expression profile of ADAM12 in breast cancers in comparison with normal breast and to correlate their level of expression with the clinical and pathological characteristics of breast cancers. Gene expression of ADAM12 spliced variants (12L and 12S) was evaluated using quantitative reverse-transcription PCR in samples obtained by laser capture microdissection from 38 patients with breast cancers and compared with adjacent healthy breast tissues. Both ADAM12L and 12S expression were significantly up-regulated in breast cancers, while in the normal breast, we found a very low expression. ADAM12L expression was significantly correlated with the histopathological types and, although not statistically significant, ADAM12 both variants were up-regulated in high-grade, highly-proliferative and HER2÷neu positive tumors. From these preliminary results, we found that ADAM12 could be an interesting marker and eventually a therapeutic target for breast cancer.

  16. ADAM17 Transactivates EGFR Signaling during Embryonic Eyelid Closure

    PubMed Central

    Hassemer, Eryn L.; Endres, Bradley; Toonen, Joseph A.; Ronchetti, Adam; Dubielzig, Richard; Sidjanin, Duska J.

    2013-01-01

    Purpose. During mammalian embryonic eyelid closure ADAM17 has been proposed to play a role as a transactivator of epidermal growth factor receptor (EGFR) signaling by shedding membrane bound EGFR ligands. However, ADAM17 also sheds numerous other ligands, thus implicating ADAM17 in additional molecular pathways. The goal of this study was to experimentally establish the role of ADAM17 and determine ADAM17-mediated pathways essential for the embryonic eyelid closure. Methods. Wild-type (WT) and woe mice, carrying a hypomorphic mutation in Adam17, were evaluated using H&E and scanning electron microscopy. Expressions of ADAM17, EGFR, and the phosphorylated form EGFR-P were evaluated using immunohistochemistry. BrdU and TUNEL assays were used to evaluate cell proliferation and apoptosis, respectively. In vitro scratch assays of primary cultures were used to evaluate cell migration. Clinical and histologic analyses established if the hypermorphic EgfrDsk5 allele can rescue the woe embryonic eyelid closure. Results. woe mice exhibited a failure to develop the leading edge of the eyelid and consequently failure of the embryonic eyelid closure. Expression of ADAM17 was identified in the eyelid epithelium in the cells of the leading edge. ADAM17 is essential for epithelial cell migration, but does not play a role in proliferation and apoptosis. EGFR was expressed in both WT and woe eyelid epithelium, but the phosphorylated EGFR-P form was detected only in WT. The EgfrDsk5 allele rescued woe eyelid closure defects, but also rescued woe anterior segment defects and the absence of meibomian glands. Conclusions. We provide in vivo genetic evidence that the role of ADAM17 during embryonic eyelid closure is to transactivate EGFR signaling. PMID:23211830

  17. Helping Eve overcome ADAM: G-quadruplexes in the ADAM-15 promoter as new molecular targets for breast cancer therapeutics.

    PubMed

    Brown, Robert V; Gaerig, Vanessa C; Simmons, Taesha; Brooks, Tracy A

    2013-12-05

    ADAM-15, with known zymogen, secretase, and disintegrin activities, is a catalytically active member of the ADAM family normally expressed in early embryonic development and aberrantly expressed in various cancers, including breast, prostate and lung. ADAM-15 promotes extracellular shedding of E-cadherin, a soluble ligand for the HER2/neu receptor, leading to activation, increased motility, and proliferation. Targeted downregulation of both ADAM-15 and HER2/neu function synergistically kills breast cancer cells, but to date there are no therapeutic options for decreasing ADAM-15 function or expression. In this vein, we have examined a unique string of guanine-rich DNA within the critical core promoter of ADAM-15. This region of DNA consists of seven contiguous runs of three or more consecutive guanines, which, under superhelical stress, can relax from duplex DNA to form an intrastrand secondary G-quadruplex (G4) structure. Using biophysical and biological techniques, we have examined the G4 formation within the entire and various truncated regions of the ADAM-15 promoter, and demonstrate strong intrastrand G4 formation serving to function as a biological silencer element. Characterization of the predominant G4 species formed within the ADAM-15 promoter will allow for specific drug targeting and stabilization, and the further development of novel, targeted therapeutics.

  18. Rocky Mountain Spotted Fever (For Parents)

    MedlinePlus

    ... Safety for the Whole Family Evaluate Your Child's Lyme Disease Risk Lyme Disease Lyme Disease Hey! A Tick Bit Me! Bug Bites and Stings Rocky Mountain Spotted Fever Lyme Disease Contact Us Print Resources Send to a friend ...

  19. Kepler Discovers Its First Rocky Planet

    NASA Video Gallery

    NASA's Kepler mission confirmed the discovery of its first rocky planet, named Kepler-10b. Measuring 1.4 times the size of Earth, it is the smallest planet ever discovered outside our solar system....

  20. Environmental Assessment for Lock and Dam 21 Major Rehabilitation, Marion County, Missouri and Adams County, Illinois.

    DTIC Science & Technology

    1987-02-01

    exceeded the State standards; however, most metal concentrations were below their respective detection limits. All pesticide concentrations were below...them in the "heavily polluted" category. Cyanide, mercury, polychlorinated biphenyls, and all pesticide concentrations, except for 2,4-D were below... alternitIves have been identified. The proposed actions arf in (ompliance with Sectf,:i; 4c4(b)(l) of the Clean Water Act, as amended. The proposed action will

  1. A Disintegrin and Metalloproteinase10 (ADAM10) Regulates NOTCH Signaling during Early Retinal Development.

    PubMed

    Toonen, Joseph A; Ronchetti, Adam; Sidjanin, D J

    2016-01-01

    ADAM10 and ADAM17 are two closely related members of the ADAM (a disintegrin and metalloprotease) family of membrane-bound sheddases, which proteolytically cleave surface membrane proteins. Both ADAM10 and ADAM17 have been implicated in the proteolytic cleavage of NOTCH receptors and as such regulators of NOTCH signaling. During retinal development, NOTCH signaling facilitates retinal neurogenesis by maintaining progenitor cells in a proliferative state and by mediating retinal cell fates. However, the roles of ADAM10 and ADAM17 in the retina are not well defined. In this study, we set out to clarify the roles of ADAM10 and ADAM17 during early retinal development. The retinal phenotype of conditionally abated Adam17 retinae (Adam17 CKO) did not differ from the controls whereas conditionally ablated Adam10 retinae (Adam10 CKO) exhibited abnormal morphogenesis characterized by the formation of rosettes and a loss of retinal laminae phenotypically similar to morphological abnormalities identified in mice with retinal NOTCH signaling deficiency. Additionally, Adam10 CKO retinae exhibited abnormal neurogenesis characterized by fewer proliferating progenitor cells and greater differentiation of early photoreceptors and retinal ganglion cells. Moreover, constitutive activation of the NOTCH1-intracellular domain (N1-ICD) rescued Adam10 CKO abnormal neurogenesis, as well as abnormal retinal morphology by maintaining retinal cells in the progenitor state. Collectively these findings provide in vivo genetic evidence that ADAM10, and not ADAM17, is indispensable for proper retinal development as a regulator of NOTCH signaling.

  2. A Disintegrin and Metalloproteinase10 (ADAM10) Regulates NOTCH Signaling during Early Retinal Development

    PubMed Central

    Toonen, Joseph A.; Ronchetti, Adam; Sidjanin, D. J.

    2016-01-01

    ADAM10 and ADAM17 are two closely related members of the ADAM (a disintegrin and metalloprotease) family of membrane-bound sheddases, which proteolytically cleave surface membrane proteins. Both ADAM10 and ADAM17 have been implicated in the proteolytic cleavage of NOTCH receptors and as such regulators of NOTCH signaling. During retinal development, NOTCH signaling facilitates retinal neurogenesis by maintaining progenitor cells in a proliferative state and by mediating retinal cell fates. However, the roles of ADAM10 and ADAM17 in the retina are not well defined. In this study, we set out to clarify the roles of ADAM10 and ADAM17 during early retinal development. The retinal phenotype of conditionally abated Adam17 retinae (Adam17 CKO) did not differ from the controls whereas conditionally ablated Adam10 retinae (Adam10 CKO) exhibited abnormal morphogenesis characterized by the formation of rosettes and a loss of retinal laminae phenotypically similar to morphological abnormalities identified in mice with retinal NOTCH signaling deficiency. Additionally, Adam10 CKO retinae exhibited abnormal neurogenesis characterized by fewer proliferating progenitor cells and greater differentiation of early photoreceptors and retinal ganglion cells. Moreover, constitutive activation of the NOTCH1-intracellular domain (N1-ICD) rescued Adam10 CKO abnormal neurogenesis, as well as abnormal retinal morphology by maintaining retinal cells in the progenitor state. Collectively these findings provide in vivo genetic evidence that ADAM10, and not ADAM17, is indispensable for proper retinal development as a regulator of NOTCH signaling. PMID:27224017

  3. Adam Paulsen, a Pioneer in Auroral Research

    NASA Astrophysics Data System (ADS)

    Jørgensen, Torben S.; Rasmussen, Ole

    2006-02-01

    The 20 to 30 years following the first International Polar Year in 1882-1883 was a period of quickly advancing knowledge and understanding of auroral phenomena. This was the time when hypotheses of aurora being due to, for example, reflections of fires from the interior of the Earth or sunlight from ice particles were abandoned and replaced by the mechanism of precipitating electrons. One of the auroral researchers at that time was the Dane Adam Frederik Wivet Paulsen (1833-1907). However, when reading literature about auroral history, his ideas and work do not seem to have attracted much interest outside his own and neighboring countries. For example, in his sweeping historical account Majestic Lights: The Aurora in Science, History, and the Arts [1980], author Robert Eather only referred to Paulsen in a couple of lines.

  4. Species Specificity of ADAM10 and ADAM17 Proteins in Interleukin-6 (IL-6) Trans-signaling and Novel Role of ADAM10 in Inducible IL-6 Receptor Shedding*

    PubMed Central

    Garbers, Christoph; Jänner, Nathalie; Chalaris, Athena; Moss, Marcia L.; Floss, Doreen M.; Meyer, Dörte; Koch-Nolte, Friedrich; Rose-John, Stefan; Scheller, Jürgen

    2011-01-01

    Hypomorphic ADAM17ex/ex mice showed defects in mucosal regeneration due to inefficient enhanced GFR shedding. ADAM17 is the main sheddase of interleukin-6 receptor (IL-6R) to induce IL-6 trans-signaling. However, serum levels of soluble murine IL-6R were not reduced in ADAM17ex/ex mice, and murine ADAM17 was not the major sheddase of murine IL-6R. Shedding of murine IL-6R by murine ADAM17 was rescued in chimeric murine IL-6R proteins containing any extracellular domain but not the transmembrane and intracellular domain of human IL-6R. Apoptosis is a physiological stimulus of ADAM17-mediated shedding of human IL-6R. Even though apoptosis induced IL-6R shedding in mice, the responsible protease was identified as ADAM10. ADAM10 also was identified as protease responsible for ionomycin-induced shedding of murine and human IL-6R. However, in ADAM10-deficient murine embryonic fibroblasts, compensatory shedding of human IL-6R was mediated by ADAM17, but loss of ADAM10-mediated shedding of murine IL-6R was compensated by an as-yet-unidentified protease. Finally, we identified physiological purinergic P2X7 receptor stimulation as a novel inducer of murine and human IL-6R shedding solely mediated by ADAM10. In conclusion, we describe an unexpected species specificity of ADAM10 and ADAM17 and identified ADAM10 as novel inducible sheddase of IL-6R in mice and humans, which might have consequences for the interpretation of phenotypes from ADAM17- and ADAM10-deficient mice. PMID:21454673

  5. Integrated Hatchery Operations Team: Operations Plans for Anadromous Fish Production Facilities in the Columbia River Basin, Volume IV of IV; Washington: Rocky Reach Hatchery Addendum, 1992 Annual Report.

    SciTech Connect

    Peck, Larry

    1993-08-01

    Rocky Reach Hatchery is located along the Columbia Paver, just downstream from Rocky Reach Dam. Site elevation is 800 feet above sea level. The Turtle Rock Island facility, located 2 miles upstream, is operated as a satellite facility (shared with the Washington Department of Wildlife). The facility is staffed with 2.75 FTE`S. The hatchery was originally designed as a mile-long spawning channel at Turtle Rock Island. Rearing units consist of eight vinyl raceways at Rocky Reach and four rearing ponds at Turtle Rock. Water rights are held by Chelan County PUD and total 3,613 gpm from the Columbia River. Water available for use in the Turtle Rock rearing ponds averages 12,000 gpm from the Columbia River. Rocky Reach Hatchery and the Turtle Rock satellite facility are owned by Chelan County PUD. They are operated as mitigation facilities for the fishery impacts caused by the construction and operation of Rocky Reach Dam. Rocky Reach Hatchery is used for incubation and early rearing of upriver bright (URB) fall chinook. Fingerlings are later transferred to the Turtle Rock facility for final rearing and release.

  6. ADAM-17: The Enzyme That Does It All

    PubMed Central

    Gooz, Monika

    2010-01-01

    This review focuses on the role of ADAM-17 in disease. Since its debut as the tumor necrosis factor converting enzyme or TACE, ADAM-17 has been reported to be an indispensible regulator of almost every cellular event from proliferation to migration. The central role of ADAM-17 in cell regulation is rooted in its diverse array of substrates: cytokines, growth factors, and their receptors as well as adhesion molecules are activated or inactivated by their cleavage with ADAM-17. It is therefore not surprising that ADAM-17 is implicated in numerous human diseases including cancer, heart disease, diabetes, rheumatoid arthritis, kidney fibrosis, Alzheimer’s disease, and is a promising target for future treatments. The specific role of ADAM-17 in the pathophysiology of these diseases is very complex and depends on the cellular context. To exploit the therapeutic potential of ADAM-17, it is important to understand how its activity is regulated and how specific organs and cells can be targeted to inactivate or activate the enzyme. PMID:20184396

  7. Rocky Flats beryllium health surveillance

    SciTech Connect

    Stange, A.W.; Furman, F.J.; Hilmas, D.E.

    1996-10-01

    The Rocky Flats Beryllium Health Surveillance Program (BHSP), initiated in June 1991, was designed to provide medical surveillance for current and former employees exposed to beryllium. The BHSP identifies individuals who have developed beryllium sensitivity using the beryllium lymphocyte proliferation test (BeLPT). A detailed medical evaluation to determine the prevalence of chronic beryllium disease (CBD) is offered to individuals identified as beryllium sensitized or to those who have chest X-ray changes suggestive of CBD. The BHSP has identified 27 cases of CBD and another 74 cases of beryllium sensitization out of 4268 individuals tested. The distribution of BeLPT values for normal, sensitized, and CBD-identified individuals is described. Based on the information collected during the first 3 1/3 years of the BHSP, the BeLPT is the most effective means for the early identification of beryllium-sensitized individuals and to identify individuals who may have CBD. The need for BeLPT retesting is demonstrated through the identification of beryllium sensitization in individuals who previously tested normal. Posterior/anterior chest X-rays were not effective in the identification of CBD. 12 refs., 8 tabs.

  8. Control design and simulation of systems modeled using ADAMS

    NASA Technical Reports Server (NTRS)

    Sohoni, Vikram N.

    1989-01-01

    A technique for control design and simulation using the ADAMS software and a control design software package is presented. For design of control systems ADAMS generates a minimum realization linear time invariant (LTI), state space representation of multi-body models. This LTI representation can be produced in formats for input to several commercial control design packages. The user can exercise various design strategies in the control design software to arrive at a suitable compensator. The resulting closed loop model can then be simulated using ADAMS. This procedure is illustrated with two examples.

  9. ADAM15 expression is downregulated in melanoma metastasis compared to primary melanoma

    SciTech Connect

    Ungerer, Christopher; Doberstein, Kai; Boehm, Beate; Pfeilschifter, Josef; Mihic-Probst, Daniela; Gutwein, Paul

    2010-10-22

    Research highlights: {yields} Strong ADAM15 expression is found in normal melanocytes. {yields} ADAM15 expression is significantly downregulated in patients with melanoma metastasis. {yields} TGF-{beta} can downregulate ADAM15 expression in melanoma cells. {yields} Overexpression of ADAM15 in melanoma cells inhibits migration, proliferation and invasion of melanoma cells. {yields} Conclusion: ADAM15 represents an tumor suppressor protein in melanoma. -- Abstract: In a mouse melanoma metastasis model it has been recently shown that ADAM15 overexpression in melanoma cells significantly reduced the number of metastatic nodules on the lung. Unfortunately, the expression of ADAM15 in human melanoma tissue has not been determined so far. In our study, we characterized the expression of ADAM15 in tissue micro-arrays of patients with primary melanoma with melanoma metastasis. ADAM15 was expressed in melanocytes and endothelial cells of benign nevi and melanoma tissue. Importantly, ADAM15 was significantly downregulated in melanoma metastasis compared to primary melanoma. We further demonstrate that IFN-{gamma} and TGF-{beta} downregulate ADAM15 protein levels in melanoma cells. To investigate the role of ADAM15 in melanoma progression, we overexpressed ADAM15 in melanoma cells. Importantly, overexpression of ADAM15 in melanoma cells reduced the migration, invasion and the anchorage dependent and independent cell growth of melanoma cells. In summary, the downregulation of ADAM15 plays an important role in melanoma progression and ADAM15 act as a tumorsuppressor in melanoma.

  10. Polarimetry for rocky exoplanet characterization

    NASA Astrophysics Data System (ADS)

    Stam, Daphne; Karalidi, Theodora

    2013-04-01

    Since the first discovery of a planet around a solar-type star by Mayor & Queloz in 1995, several hundreds of exoplanets have been detected. Indeed, it appears that practically all Sun-like stars have planets. Inevitable, Earth-sized, rocky planets that orbit in their star's habitable zone, where temperatures could be just right to allow liquid water on a planet's surface, will be found. Liquid water is generally considered to be essential for the existence of life. Whether liquid water actually exists on a planet depends strongly on the atmosphere's thickness and characteristics, such as the surface pressure and composition. Famous examples in the Solar System are Venus and the Earth, with similar sizes, inner compositions and orbital radii, but wildly different surface conditions. The characterization of the atmospheres and/or surfaces of exoplanets will allow a comparison with Solar System planets and it will open up a treasure trove of knowledge about the formation and evolution of planetary atmospheres and surfaces, thanks to the vast range of orbital distances, planet sizes and ages that can be studied. Characterization will also allow studying conditions for life and ultimately the existence of life around other stars. Information about the upper atmospheres of close-in, hot, giant exoplanets, can be derived from measurements of the combined flux of the star and the planet, in particular when the planet is transiting its star. This method has also provided traces of an atmosphere around a large solid planet orbiting red dwarf star GJ1214. Detection and characterization of the atmospheres and/or surfaces of small, solid, Earth-like exoplanets in the habitable zones of Sun-like stars, is virtually impossible with transit observations. For these exiting planets, polarimetry appears to be a strong tool. Polarimetry helps the detection of exoplanets, because direct starlight is usually unpolarized, while starlight that has been reflected by a planet is usually

  11. Folding above faults, Rocky Mountains

    SciTech Connect

    McConnell, D.A. . Dept. of Geology)

    1992-01-01

    Asymmetric folds formed above basement faults can be observed throughout the Rocky Mountains. Several previous interpretations of the folding process made the implicit assumption that one or both fold hinges migrated or rolled'' through the steep forelimb of the fold as the structure evolved (rolling hinge model). Results of mapping in the Bighorn and Seminoe Mountains, WY, and Sangre de Cristo Range, CO, do not support this hypothesis. An alternative interpretation is presented in which fold hinges remained fixed in position during folding (fixed hinge model). Mapped folds share common characteristics: (1) axial traces of the folds intersect faults at or near the basement/cover interface, and diverge from faults upsection; (2) fold hinges are narrow and interlimb angles cluster around 80--100[degree] regardless of fold location; (3) fold shape is typically angular, despite published cross sections that show concentric folds; and, (4) beds within the folds show thickening and/or thinning, most commonly adjacent to fold hinges. The rolling hinge model requires that rocks in the fold forelimbs bend through narrow fold hinges as deformation progressed. Examination of massive, competent rock units such as the Ord. Bighorn Dolomite, Miss. Madison Limestone, and, Penn. Tensleep Sandstone reveals no evidence of the extensive internal deformation that would be expected if hinges rolled through rocks of the forelimb. The hinges of some folds (e.g. Golf Creek anticline, Bighorn Mountains) are offset by secondary faults, effectively preventing the passage of rocks from backlimb to forelimb. The fixed hinge model proposes that the fold hinges were defined early in fold evolution, and beds were progressively rotated and steepened as the structure grew.

  12. ADAM12 transmembrane and secreted isoforms promote breast tumor growth: a distinct role for ADAM12-S protein in tumor metastasis.

    PubMed

    Roy, Roopali; Rodig, Scott; Bielenberg, Diane; Zurakowski, David; Moses, Marsha A

    2011-06-10

    Increased levels of ADAM12 have been reported in a variety of human cancers. We have previously reported that urinary ADAM12 is predictive of disease status in breast cancer patients and that ADAM12 protein levels in urine increase with progression of disease. On the basis of these findings, the goal of this study was to elucidate the contribution of ADAM12 in breast tumor growth and progression. Overexpression of both the ADAM12-L (transmembrane) and ADAM12-S (secreted) isoforms in human breast tumor cells resulted in a significantly higher rate of tumor take and increased tumor size. Cells expressing the enzymatically inactive form of the secreted isoform, ADAM12-S, had tumor take rates and tumor volumes similar to those of wild-type cells, suggesting that the tumor-promoting activity of ADAM12-S was a function of its proteolytic activity. Of the two isoforms, only the secreted isoform, ADAM12-S, enhanced the ability of tumor cells to migrate and invade in vitro and resulted in a higher incidence of local and distant metastasis in vivo. This stimulatory effect of ADAM12-S on migration and invasion was dependent on its catalytic activity. Expression of both ADAM12 isoforms was found to be significantly elevated in human malignant breast tissue. Taken together, our results suggest that ADAM12 overexpression results in increased tumor take, tumor size, and metastasis in vivo. These findings suggest that ADAM12 may represent a potential therapeutic target in breast cancer.

  13. Mars rover mechanisms designed for Rocky 4

    NASA Technical Reports Server (NTRS)

    Rivellini, Tommaso P.

    1993-01-01

    A Mars rover prototype vehicle named Rocky 4 was designed and built at JPL during the fall of 1991 and spring 1992. This vehicle is the fourth in a series of rovers designed to test vehicle mobility and navigation software. Rocky 4 was the first attempt to design a vehicle with 'flight like' mass and functionality. It was consequently necessary to develop highly efficient mechanisms and structures to meet the vehicles very tight mass limit of 3 Kg for the entire mobility system (7 Kg for the full system). This paper will discuss the key mechanisms developed for the rover's innovative drive and suspension system. These are the wheel drive and strut assembly, the rocker-bogie suspension mechanism and the differential pivot. The end-to-end design, analysis, fabrication and testing of these components will also be discussed as will their performance during field testing. The lessons learned from Rocky 4 are already proving invaluable for the design of Rocky 6. Rocky 6 is currently being designed to fly on NASA's MESUR mission to Mars scheduled to launch in 1996.

  14. Rocky Mountain spotted fever. Serological evidence of previous subclinical infection in children.

    PubMed

    Marx, R S; McCall, C E; Abramson, J S; Harlan, J E

    1982-01-01

    Serological tests for Rocky Mountain spotted fever were performed on single serum specimens from sixth graders from Forsyth County, North Carolina, an area highly endemic for this disease. Five of 508 *.098%) sera were positive (titer greater than or equal to 1:64) using the indirect fluorescent antibody method. Elevated Proteus agglutination antibody titers (greater than 1:160) to OX-19, but not ot OX-2, were common (19.6%) in these children. No correlation of those with positive OX-19 titers could be made with the cases demonstrating elevated indirect fluorescent antibody titers or with a history of urinary tract infection. These data suggest that the increased prevalence of elevated Proteus OX-19 antibody levels makes a single high titer unreliable in the diagnosis of Rocky Mountain spotted fever and that naturally acquired mild or asymptomatic subclinical cases of Rickettsia rickttsii infection occur.

  15. N-Glycosylation Regulates ADAM8 Processing and Activation*

    PubMed Central

    Srinivasan, Srimathi; Romagnoli, Mathilde; Bohm, Andrew; Sonenshein, Gail E.

    2014-01-01

    The transmembrane ADAM8 (A Disintegrin And Metalloproteinase 8) protein is abundantly expressed in human breast tumors and derived metastases compared with normal breast tissue, and plays critical roles in aggressive Triple-Negative breast cancers (TNBCs). During ADAM8 maturation, the inactive proform dimerizes or multimerizes and autocatalytically removes the prodomain leading to the formation of the active, processed form. ADAM8 is a glycoprotein; however, little was known about the structure or functional role of these sugar moieties. Here, we report that in estrogen receptor (ER)α-negative, but not -positive, breast cancer cells ADAM8 contains N-glycosylation, which is required for its correct processing and activation. Consistently ADAM8 dimers were detected on the surface of ERα-negative breast cancer cells but not on ERα-positive ones. Site-directed mutagenesis confirmed four N-glycosylazhytion sites (Asn-67, Asn-91, Asn-436, and Asn-612) in human ADAM8. The Asn-67 and Asn-91 prodomain sites contained high mannose, whereas complex type N-glycosylation was observed on Asn-436 and Asn-612 in the active and remnant forms. The Asn-91 and Asn-612 sites were essential for its correct processing and cell surface localization, in particular its exit from the Golgi and endoplasmic reticulum, respectively. The N436Q mutation led to decreased ADAM8 stability due to enhanced lysosomal degradation. In contrast, mutation of the Asn-67 site had only modest effects on enzyme stability and processing. Thus, N-glycosylation is essential for processing, localization, stability, and activity of ADAM8. PMID:25336660

  16. ADAM17 substrate release in proximal tubule drives kidney fibrosis

    PubMed Central

    Kefaloyianni, Eirini; Muthu, Muthu Lakshmi; Kaeppler, Jakob; Sun, Xiaoming; Sabbisetti, Venkata; Chalaris, Athena; Rose-John, Stefan; Wong, Eitan; Sagi, Irit; Waikar, Sushrut S.; Rennke, Helmut; Bonventre, Joseph V.

    2016-01-01

    Kidney fibrosis following kidney injury is an unresolved health problem and causes significant morbidity and mortality worldwide. In a study into its molecular mechanism, we identified essential causative features. Acute or chronic kidney injury causes sustained elevation of a disintegrin and metalloprotease 17 (ADAM17); of its cleavage-activated proligand substrates, in particular of pro-TNFα and the EGFR ligand amphiregulin (pro-AREG); and of the substrates’ receptors. As a consequence, EGFR is persistently activated and triggers the synthesis and release of proinflammatory and profibrotic factors, resulting in macrophage/neutrophil ingress and fibrosis. ADAM17 hypomorphic mice, specific ADAM17 inhibitor–treated WT mice, or mice with inducible KO of ADAM17 in proximal tubule (Slc34a1-Cre) were significantly protected against these effects. In vitro, in proximal tubule cells, we show that AREG has unique profibrotic actions that are potentiated by TNFα-induced AREG cleavage. In vivo, in acute kidney injury (AKI) and chronic kidney disease (CKD, fibrosis) patients, soluble AREG is indeed highly upregulated in human urine, and both ADAM17 and AREG expression show strong positive correlation with fibrosis markers in related kidney biopsies. Our results indicate that targeting of the ADAM17 pathway represents a therapeutic target for human kidney fibrosis. PMID:27642633

  17. Alternative mRNA splicing generates two distinct ADAM12 prodomain variants.

    PubMed

    Duhachek-Muggy, Sara; Li, Hui; Qi, Yue; Zolkiewska, Anna

    2013-01-01

    Human ADAM12, transcript variant 1 (later on referred to as Var-1b), present in publicly available databases contains the sequence 5'-GTAATTCTG-3' at the nucleotide positions 340-348 of the coding region, at the 3' end of exon 4. The translation product of this variant, ADAM12-Lb, includes the three amino acid motif (114)VIL(116) in the prodomain. This motif is not conserved in ADAM12 from different species and is not present in other human ADAMs. Currently, it is not clear whether a shorter variant, Var-1a, encoding the protein version without the (114)VIL(116) motif, ADAM12-La, is expressed in human. In this work, we have established that human mammary epithelial cells and breast cancer cells express both Var-1a and Var-1b transcripts. Importantly, the proteolytic processing and intracellular trafficking of the corresponding ADAM12-La and ADAM12-Lb proteins are different. While ADAM12-La is cleaved and trafficked to the cell surface in a manner similar to ADAM12 in other species, ADAM12-Lb is retained in the ER and is not proteolytically processed. Furthermore, the relative abundance of ADAM12-La and ADAM12-Lb proteins detected in several breast cancer cell lines varies significantly. We conclude that the canonical form of transmembrane ADAM12 is represented by Var-1a/ADAM12-La, rather than Var-1b/ADAM12-Lb currently featured in major sequence databases.

  18. A case of Rocky Mountain spotted fever.

    PubMed

    Rubel, Barry S

    2007-01-01

    Rocky Mountain spotted fever is a serious, generalized infection that is spread to humans through the bite of infected ticks. It can be lethal but it is curable. The disease gets its name from the Rocky Mountain region where it was first identified in 1896. The fever is caused by the bacterium Rickettsia rickettsii and is maintained in nature in a complex life cycle involving ticks and mammals. Humans are considered to be accidental hosts and are not involved in the natural transmission cycle of this pathogen. The author examined a 47-year-old woman during a periodic recall appointment. The patient had no dental problems other than the need for routine prophylaxis but mentioned a recent problem with swelling of her extremities with an accompanying rash and general malaise and soreness in her neck region. Tests were conducted and a diagnosis of Rocky Mountain spotted fever was made.

  19. TACE (ADAM17) inhibits Schwann cell myelination.

    PubMed

    La Marca, Rosa; Cerri, Federica; Horiuchi, Keisuke; Bachi, Angela; Feltri, M Laura; Wrabetz, Lawrence; Blobel, Carl P; Quattrini, Angelo; Salzer, James L; Taveggia, Carla

    2011-06-12

    Tumor necrosis factor-α-converting enzyme (TACE; also known as ADAM17) is a proteolytic sheddase that is responsible for the cleavage of several membrane-bound molecules. We report that TACE cleaves neuregulin-1 (NRG1) type III in the epidermal growth factor domain, probably inactivating it (as assessed by deficient activation of the phosphatidylinositol-3-OH kinase pathway), and thereby negatively regulating peripheral nervous system (PNS) myelination. Lentivirus-mediated knockdown of TACE in vitro in dorsal root ganglia neurons accelerates the onset of myelination and results in hypermyelination. In agreement, motor neurons of conditional knockout mice lacking TACE specifically in these cells are significantly hypermyelinated, and small-caliber fibers are aberrantly myelinated. Further, reduced TACE activity rescues hypomyelination in NRG1 type III haploinsufficient mice in vivo. We also show that the inhibitory effect of TACE is neuron-autonomous, as Schwann cells lacking TACE elaborate myelin of normal thickness. Thus, TACE is a modulator of NRG1 type III activity and is a negative regulator of myelination in the PNS.

  20. Adam Politzer-Father of Modern Otology.

    PubMed

    Dhungat, J V Pai; Gore, Geeta

    2015-09-01

    Adam Politzer (1835-1920) was born in Alberti near the city of Budapest in Hungary. He studied medicine at the University of Vienna and obtained his Doctorate degree in 1859. Some of his teachers belonged to the famous second "Vienna School" such as Joseph Skoda, Karl Rokitansky, Von Hebra, Josef Hyrtil, Johann Von Oppolzer and famous physiologist Carl Ludwig -who took special interest in him and was influential in his subsequent career. Politzer showed unusual interest in diseases of the ear and started to work in Carl Ludwig's laboratory. His interest at that time was mainly the physics of the auditory system. He studied the innervations of the intrinsic muscles of the ear There he was the first to demonstrate that the innervations of the tensor tympani muscle was by trigeminal nerve and that of the stapedial muscle was by facial nerve. He studied the air movement in the Eustachian tube and variation of air pressure in the tympanic cavity by connecting two manometers- one placed in the external auditory canal meatus, and another in the pharynx. He showed valve near the opening into the middle ear which controls the process. It is usually closed to keep the bacteria and other things away from the mouth and nose.

  1. Consequences of early snowmelt in Rocky Mountains

    NASA Astrophysics Data System (ADS)

    Balcerak, Ernie

    2013-01-01

    Snow melted significantly earlier in the Rocky Mountains in 2012 than in previous years, with serious consequences for plants and animals, scientists reported at the AGU Fall Meeting. David Inouye of the University of Maryland, College Park, and the Rocky Mountain Biological Laboratory said that "the timing of winter's end is changing." He has been observing snowmelt dates and flowering of plants at a site at 2900 meters altitude. This year's snowmelt occurred 23 April, whereas the previous year, snow melted 19 June, he reported.

  2. ADAM12 induces estrogen-independence in breast cancer cells.

    PubMed

    Roy, Roopali; Moses, Marsha A

    2012-02-01

    Antiestrogen therapy has been used successfully to prolong disease-free and overall survival of ER positive breast cancer patients. However, 50% of patients with ER+ tumors fail to respond to such therapy or eventually acquire resistance to endocrine therapy, resulting in tumor progression and mortality. It is imperative, therefore, to understand the mechanisms that lead to hormone refractory breast cancer in order to develop therapeutics that can modulate the resistance to antiestrogen therapy. The protease, ADAM12, can be detected in the urine of breast cancer patients and its levels correlate with disease status, stage, and cancer risk. Within the context of this study, the authors have investigated the role of the two distinct isoforms of ADAM12 in breast tumor cell proliferation and as potential mediators of endocrine resistance. Using stable clones of ADAM12-overexpressing MCF-7 cells, the authors analyzed proliferation rates of these ER+ breast tumor cells both in estrogen-depleted medium and in the presence of the antiestrogens, tamoxifen, and ICI 182,780. Acquired estrogen resistance in these cells was analyzed using phospho-RTK analysis. Upregulation and phosphorylation of proteins were detected via immunoprecipitation and immunoblotting. EGFR and MAPK inhibitors were used to explore the mechanism of acquired estrogen resistance in breast tumor cells. It was observed that overexpression of the two isoforms, transmembrane ADAM12-L, and secreted ADAM12-S, in breast tumor cells promoted estrogen-independent proliferation. In ADAM12-L-expressing cells, estrogen-independence was a direct result of increased EGFR expression and MAPK activation, whereas, the mechanism in ADAM12-S-expressing cells may be enhanced IGF-1R signaling. The importance of the EGFR signaling pathway in the estrogen-independent growth of ADAM12-L expressing cells was highlighted by the effect of EGFR inhibitors AG1478 and PD15035 or MAPK inhibitor U0126, each of which abolished the

  3. The ADAMs family of proteases: new biomarkers and therapeutic targets for cancer?

    PubMed Central

    2011-01-01

    The ADAMs are transmembrane proteins implicated in proteolysis and cell adhesion. Forty gene members of the family have been identified, of which 21 are believed to be functional in humans. As proteases, their main substrates are the ectodomains of other transmembrane proteins. These substrates include precursor forms of growth factors, cytokines, growth factor receptors, cytokine receptors and several different types of adhesion molecules. Although altered expression of specific ADAMs has been implicated in different diseases, their best-documented role is in cancer formation and progression. ADAMs shown to play a role in cancer include ADAM9, ADAM10, ADAM12, ADAM15 and ADAM17. Two of the ADAMs, i.e., ADAM10 and 17 appear to promote cancer progression by releasing HER/EGFR ligands. The released ligands activate HER/EGFR signalling that culminates in increased cell proliferation, migration and survival. Consistent with a causative role in cancer, several ADAMs are emerging as potential cancer biomarkers for aiding cancer diagnosis and predicting patient outcome. Furthermore, a number of selective ADAM inhibitors, especially against ADAM10 and ADAM17, have been shown to have anti-cancer effects. At least one of these inhibitors is now undergoing clinical trials in patients with breast cancer. PMID:21906355

  4. Taking Charge: Walter Sydney Adams and the Mount Wilson Observatory

    NASA Astrophysics Data System (ADS)

    Brashear, R.

    2004-12-01

    The growing preeminence of American observational astronomy in the first half of the 20th century is a well-known story and much credit is given to George Ellery Hale and his skill as an observatory-building entrepreneur. But a key figure who has yet to be discussed in great detail is Walter Sydney Adams (1876-1956), Hale's Assistant Director at Mount Wilson Observatory. Due to Hale's illnesses, Adams was Acting Director for much of Hale's tenure, and he became the second Director of Mount Wilson from 1923 to 1946. Behind his New England reserve Adams was instrumental in the growth of Mount Wilson and thus American astronomy in general. Adams was hand-picked by Hale to take charge of stellar spectroscopy work at Yerkes and Mount Wilson and the younger astronomer showed tremendous loyalty to Hale and Hale's vision throughout his career. As Adams assumed the leadership role at Mount Wilson he concentrated on making the observatory a place where researchers worked with great freedom but maintain a high level of cooperation. This paper will concentrate on Adams's early years and look at his growing relationship with Hale and how he came to be the central figure in the early history of Mount Wilson as both a solar and stellar observatory. His education, his years at Dartmouth and Yerkes (including his unfortunate encounter with epsilon Leonis), and his formative years on Mount Wilson are all important in learning how he shaped the direction of Mount Wilson and the development of American astronomy in the first half of the 20th century. This latter history cannot be complete until we bring Adams into better focus.

  5. Rocky Mountain Spotted Fever in Argentina

    Technology Transfer Automated Retrieval System (TEKTRAN)

    We describe the first molecular confirmation of Rickettsia rickettsii, the cause of Rocky Mountain spotted fever (RMSF), from a tick vector, Amblyomma cajennense, and from a cluster of fatal spotted fever cases in Argentina. Questing A. cajennense ticks were collected at or near sites of presumed or...

  6. Rocky Mountain spotted fever in Argentina

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Cases of epidemic typhus have been documented in Argentina since 1919; however, no confirmed reports of spotted fever rickettsiosis were described in this country until 1999. We describe the first molecular confirmation of Rickettsia rickettsii, the etiologic agent of Rocky Mountain spotted fever (R...

  7. Rocky Mountain spotted fever in dogs, Brazil.

    PubMed

    Labruna, Marcelo B; Kamakura, Orson; Moraes-Filho, Jonas; Horta, Mauricio C; Pacheco, Richard C

    2009-03-01

    Clinical illness caused by Rickettsia rickettsii in dogs has been reported solely in the United States. We report 2 natural clinical cases of Rocky Mountain spotted fever in dogs in Brazil. Each case was confirmed by seroconversion and molecular analysis and resolved after doxycycline therapy.

  8. Field Trip to a Rocky Shore.

    ERIC Educational Resources Information Center

    Maine Univ., Orono. Cooperative Extension Service.

    Field trip activities designed for use on Maine's coast are provided, with brief definitions of the major physical zones to be found in this area. An introduction to the study of zonation of plants and animals living on the rocky shore is presented along with a list of the materials needed and the procedures to be followed when making a study of…

  9. Geology highlights for Ride the Rockies 2010

    USGS Publications Warehouse

    Slate, J.L.; Hess, Amber; Van Sistine, D.R.

    2010-01-01

    The author provides a brief description of the geology along the route for each day of the ride, from June 13 through June 19, 2010. Ride the Rockies begins in Grand Junction, with stops in Delta, Ouray, Durango, Pagosa Springs, Alamosa, and ends in Salida, Colorado. A small, generalized geologic map also is shown.

  10. Geology Highlights for Ride the Rockies 2009

    USGS Publications Warehouse

    Slate, Janet

    2009-01-01

    The author provides a brief description of the geology along the route for each day of the ride, from June 14 through June 19, 2009. Ride the Rockies begins and ends in Glenwood Springs, with stops in Hotchkiss, Gunnison, Salida, Leadville, Aspen, and back to Glenwood Springs, Colorado. A small, generalized geologic map also is shown.

  11. Geology highlights, Ride the Rockies 2011

    USGS Publications Warehouse

    Slate, Janet L.

    2011-01-01

    The author provides a brief description of the geology along the route for each day of the ride, from June 12 through June 17, 2011. Ride the Rockies begins in Crested Butte, Colorado, with stops in Buena Vista, Edwards, Steamboat Springs, Granby, and Georgetown. A small, generalized geologic map also is shown.

  12. Transportation Fuels Markets, Midwest and Rocky Mountain

    EIA Publications

    2017-01-01

    A new study commissioned by the U.S. Energy Information Administration (EIA), finds that changes in North American energy markets over the past decade have strengthened the supply of transportation fuels including motor gasoline, distillates, and jet fuel in the Midwest and Rocky Mountain regions.

  13. Characterization of Mammalian ADAM2 and Its Absence from Human Sperm

    PubMed Central

    Choi, Heejin; Jin, Sora; Kwon, Jun Tae; Kim, Jihye; Jeong, Juri; Kim, Jaehwan; Jeon, Suyeon; Park, Zee Yong; Jung, Kang-Jin; Park, Kwangsung; Cho, Chunghee

    2016-01-01

    The members of the ADAM (a disintegrin and metalloprotease) family are membrane-anchored multi-domain proteins that play prominent roles in male reproduction. ADAM2, which was one of the first identified ADAMs, is the best studied ADAM in reproduction. In the male germ cells of mice, ADAM2 and other ADAMs form complexes that contribute to sperm-sperm adhesion, sperm-egg interactions, and the migration of sperm in the female reproductive tract. Here, we generated specific antibodies against mouse and human ADAM2, and investigated various features of ADAM2 in mice, monkeys and humans. We found that the cytoplasmic domain of ADAM2 might enable the differential association of this protein with other ADAMs in mice. Western blot analysis with the anti-human ADAM2 antibodies showed that ADAM2 is present in the testis and sperm of monkeys. Monkey ADAM2 was found to associate with chaperone proteins in testis. In humans, we identified ADAM2 as a 100-kDa protein in the testis, but failed to detect it in sperm. This is surprising given the results in mice and monkeys, but it is consistent with the failure of ADAM2 identification in the previous proteomic analyses of human sperm. These findings suggest that the reproductive functions of ADAM2 differ between humans and mice. Our protein analysis showed the presence of potential ADAM2 complexes involving yet-unknown proteins in human testis. Taken together, our results provide new information regarding the characteristics of ADAM2 in mammalian species, including humans. PMID:27341348

  14. Phosphatidylserine exposure is required for ADAM17 sheddase function

    PubMed Central

    Sommer, Anselm; Kordowski, Felix; Büch, Joscha; Maretzky, Thorsten; Evers, Astrid; Andrä, Jörg; Düsterhöft, Stefan; Michalek, Matthias; Lorenzen, Inken; Somasundaram, Prasath; Tholey, Andreas; Sönnichsen, Frank D.; Kunzelmann, Karl; Heinbockel, Lena; Nehls, Christian; Gutsmann, Thomas; Grötzinger, Joachim; Bhakdi, Sucharit; Reiss, Karina

    2016-01-01

    ADAM17, a prominent member of the ‘Disintegrin and Metalloproteinase' (ADAM) family, controls vital cellular functions through cleavage of transmembrane substrates. Here we present evidence that surface exposure of phosphatidylserine (PS) is pivotal for ADAM17 to exert sheddase activity. PS exposure is tightly coupled to substrate shedding provoked by diverse ADAM17 activators. PS dependency is demonstrated in the following: (a) in Raji cells undergoing apoptosis; (b) in mutant PSA-3 cells with manipulatable PS content; and (c) in Scott syndrome lymphocytes genetically defunct in their capacity to externalize PS in response to intracellular Ca2+ elevation. Soluble phosphorylserine but not phosphorylcholine inhibits substrate cleavage. The isolated membrane proximal domain (MPD) of ADAM17 binds to PS but not to phosphatidylcholine liposomes. A cationic PS-binding motif is identified in this domain, replacement of which abrogates liposome-binding and renders the protease incapable of cleaving its substrates in cells. We speculate that surface-exposed PS directs the protease to its targets where it then executes its shedding function. PMID:27161080

  15. ADAM12: a genetic modifier of preclinical peripheral arterial disease

    PubMed Central

    Chen, Lingdan; Okutsu, Mitsuharu; Farber, Charles R.; Hazarika, Surovi; Jones, W. Schuyler; Craig, Damian; Marchuk, Douglas A.; Lye, R. John; Shah, Svati H.; Annex, Brian H.

    2015-01-01

    In prior studies from multiple groups, outcomes following experimental peripheral arterial disease (PAD) differed considerably across inbred mouse strains. Similarly, in humans with PAD, disease outcomes differ, even when there are similarities in risk factors, disease anatomy, arteriosclerotic burden, and hemodynamic measures. Previously, we identified a locus on mouse chromosome 7, limb salvage-associated quantitative trait locus 1 (LSq-1), which was sufficient to modify outcomes following experimental PAD. We compared expression of genes within LSq-1 in Balb/c mice, which normally show poor outcomes following experimental PAD, with that in C57Bl/6 mice, which normally show favorable outcomes, and found that a disintegrin and metalloproteinase gene 12 (ADAM12) had the most differential expression. Augmentation of ADAM12 expression in vivo improved outcomes following experimental PAD in Balb/c mice, whereas knockdown of ADAM12 made outcomes worse in C57Bl/6 mice. In vitro, ADAM12 expression modulates endothelial cell proliferation, survival, and angiogenesis in ischemia, and this appeared to be dependent on tyrosine kinase with Ig-like and EGF-like domain 2 (Tie2) activation. ADAM12 is sufficient to modify PAD severity in mice, and this likely occurs through regulation of Tie2. PMID:26163448

  16. Essential Role for ADAM19 in Cardiovascular Morphogenesis

    PubMed Central

    Zhou, Hong-Ming; Weskamp, Gisela; Chesneau, Valérie; Sahin, Umut; Vortkamp, Andrea; Horiuchi, Keisuke; Chiusaroli, Riccardo; Hahn, Rebecca; Wilkes, David; Fisher, Peter; Baron, Roland; Manova, Katia; Basson, Craig T.; Hempstead, Barbara; Blobel, Carl P.

    2004-01-01

    Congenital heart disease is the most common form of human birth defects, yet much remains to be learned about its underlying causes. Here we report that mice lacking functional ADAM19 (mnemonic for a disintegrin and metalloprotease 19) exhibit severe defects in cardiac morphogenesis, including a ventricular septal defect (VSD), abnormal formation of the aortic and pulmonic valves, leading to valvular stenosis, and abnormalities of the cardiac vasculature. During mouse development, ADAM19 is highly expressed in the conotruncus and the endocardial cushion, structures that give rise to the affected heart valves and the membranous ventricular septum. ADAM19 is also highly expressed in osteoblast-like cells in the bone, yet it does not appear to be essential for bone growth and skeletal development. Most adam19−/− animals die perinatally, likely as a result of their cardiac defects. These findings raise the possibility that mutations in ADAM19 may contribute to human congenital heart valve and septal defects. PMID:14673146

  17. ADAM12: a genetic modifier of preclinical peripheral arterial disease.

    PubMed

    Dokun, Ayotunde O; Chen, Lingdan; Okutsu, Mitsuharu; Farber, Charles R; Hazarika, Surovi; Jones, W Schuyler; Craig, Damian; Marchuk, Douglas A; Lye, R John; Shah, Svati H; Annex, Brian H

    2015-09-01

    In prior studies from multiple groups, outcomes following experimental peripheral arterial disease (PAD) differed considerably across inbred mouse strains. Similarly, in humans with PAD, disease outcomes differ, even when there are similarities in risk factors, disease anatomy, arteriosclerotic burden, and hemodynamic measures. Previously, we identified a locus on mouse chromosome 7, limb salvage-associated quantitative trait locus 1 (LSq-1), which was sufficient to modify outcomes following experimental PAD. We compared expression of genes within LSq-1 in Balb/c mice, which normally show poor outcomes following experimental PAD, with that in C57Bl/6 mice, which normally show favorable outcomes, and found that a disintegrin and metalloproteinase gene 12 (ADAM12) had the most differential expression. Augmentation of ADAM12 expression in vivo improved outcomes following experimental PAD in Balb/c mice, whereas knockdown of ADAM12 made outcomes worse in C57Bl/6 mice. In vitro, ADAM12 expression modulates endothelial cell proliferation, survival, and angiogenesis in ischemia, and this appeared to be dependent on tyrosine kinase with Ig-like and EGF-like domain 2 (Tie2) activation. ADAM12 is sufficient to modify PAD severity in mice, and this likely occurs through regulation of Tie2.

  18. Rocky Mountain snowpack physical and chemical data for selected sites, 2010

    USGS Publications Warehouse

    Ingersoll, George P.; Mast, M. Alisa; Swank, James M.; Campbell, Chelsea D.

    2010-01-01

    The Rocky Mountain Snowpack program established a network of snowpack-sampling sites in the Rocky Mountain region, from New Mexico to Montana, to monitor the chemical content of snow and to understand the effects of regional atmospheric deposition on freshwater systems. Scientists with the U.S. Geological Survey, in cooperation with the National Park Service; the U.S. Department of Agriculture Forest Service; the Colorado Department of Public Health and Environment; Teton County, Wyoming; and others, annually collected and analyzed snow-pack samples at 48 or more sites in the Rocky Mountain region during 1993-2010. Sixty-three snowpack-sampling sites were each sampled once in 2010, and those data are presented in this report. Data include acid-neutralization capacity, specific conductance, pH, hydrogen ion concentrations, dissolved concentrations of major constituents (calcium, magnesium, sodium, potassium, ammonium, chloride, sulfate, and nitrate), dissolved organic carbon concentrations, snow-water equivalent, snow depth, total mercury concentrations, and ionic charge balance. Quality-assurance data for field and laboratory blanks and field replicates for 2010 also are included.

  19. Rocky Mountain snowpack physical and chemical data for selected sites, 2009

    USGS Publications Warehouse

    Ingersoll, George P.; Mast, M. Alisa; Swank, James M.; Campbell, Chelsea D.

    2010-01-01

    The Rocky Mountain Snowpack program established a network of snowpack-sampling sites in the Rocky Mountain region from New Mexico to Montana to monitor the chemical content of snow and to understand the effects of regional atmospheric deposition. The U.S. Geological Survey, in cooperation with the National Park Service; the U.S. Department of Agriculture Forest Service; the Colorado Department of Public Health and Environment; Teton County, Wyoming; and others, collected and analyzed snowpack samples annually for 48 or more sites in the Rocky Mountain region during 1993-2009. Sixty-three snowpack-sampling sites were sampled once each in 2009 and data are presented in this report. Data include acid-neutralization capacity, specific conductance, pH, hydrogen ion concentrations, dissolved concentrations of major constituents (calcium, magnesium, sodium, potassium, ammonium, chloride, sulfate, and nitrate), dissolved organic carbon concentrations, snow-water equivalent, snow depth, total mercury concentrations, and ionic charge balance. Quality-assurance data for field and laboratory blanks and field replicates for 2009 also are included.

  20. The Adam language: Ada extended with support for multiway activities

    NASA Technical Reports Server (NTRS)

    Charlesworth, Arthur

    1993-01-01

    The Adam language is an extension of Ada that supports multiway activities, which are cooperative activities involving two or more processes. This support is provided by three new constructs: diva procedures, meet statements, and multiway accept statements. Diva procedures are recursive generic procedures having a particular restrictive syntax that facilitates translation for parallel computers. Meet statements and multiway accept statements provide two ways to express a multiway rendezvous, which is an n-way rendezvous generalizing Ada's 2-way rendezvous. While meet statements tend to have simpler rules than multiway accept statements, the latter approach is a more straightforward extension of Ada. The only nonnull statements permitted within meet statements and multiway accept statements are calls on instantiated diva procedures. A call on an instantiated diva procedure is also permitted outside a multiway rendezvous; thus sequential Adam programs using diva procedures can be written. Adam programs are translated into Ada programs appropriate for use on parallel computers.

  1. ADAM12 and ADAM17 are essential molecules for hypoxia-induced impairment of neural vascular barrier function

    PubMed Central

    Cui, Dan; Arima, Mitsuru; Takubo, Keiyo; Kimura, Tokuhiro; Horiuchi, Keisuke; Minagawa, Takuya; Matsuda, Satoshi; Ikeda, Eiji

    2015-01-01

    Neural vascular barrier is essential for the life of multicellular organisms, and its impairment by tissue hypoxia is known to be a central of pathophysiology accelerating the progression of various intractable neural diseases. Therefore, the molecules involved in hypoxia-induced impairment of vascular barrier can be the targets to establish new therapies for intractable diseases. Here, we demonstrate that a disintegrin and metalloproteinases (ADAMs) 12 and 17 expressed in endothelial cells are the molecules responsible for the impairment of neural vascular barrier by hypoxia. Brain microvascular endothelial cells in vitro lost their barrier properties immediately after hypoxic stimulation through diminished localization of claudin-5, a tight junction molecule, on cell membranes. Hypoxic disappearance of claudin-5 from cell membranes and the consequent loss of barrier properties were completely suppressed by inhibition of the metalloproteinase activity which was found to be attributed to ADAM12 and ADAM17. Inhibition of either ADAM12 or ADAM17 was sufficient to rescue the in vivo neural vasculature under hypoxia from the loss of barrier function. This is the first report to specify the molecules which are responsible for hypoxia-induced impairment of neural vascular barrier and furthermore can be the targets of new therapeutic strategies for intractable neural diseases. PMID:26242473

  2. ADAM12 and ADAM17 are essential molecules for hypoxia-induced impairment of neural vascular barrier function.

    PubMed

    Cui, Dan; Arima, Mitsuru; Takubo, Keiyo; Kimura, Tokuhiro; Horiuchi, Keisuke; Minagawa, Takuya; Matsuda, Satoshi; Ikeda, Eiji

    2015-08-05

    Neural vascular barrier is essential for the life of multicellular organisms, and its impairment by tissue hypoxia is known to be a central of pathophysiology accelerating the progression of various intractable neural diseases. Therefore, the molecules involved in hypoxia-induced impairment of vascular barrier can be the targets to establish new therapies for intractable diseases. Here, we demonstrate that a disintegrin and metalloproteinases (ADAMs) 12 and 17 expressed in endothelial cells are the molecules responsible for the impairment of neural vascular barrier by hypoxia. Brain microvascular endothelial cells in vitro lost their barrier properties immediately after hypoxic stimulation through diminished localization of claudin-5, a tight junction molecule, on cell membranes. Hypoxic disappearance of claudin-5 from cell membranes and the consequent loss of barrier properties were completely suppressed by inhibition of the metalloproteinase activity which was found to be attributed to ADAM12 and ADAM17. Inhibition of either ADAM12 or ADAM17 was sufficient to rescue the in vivo neural vasculature under hypoxia from the loss of barrier function. This is the first report to specify the molecules which are responsible for hypoxia-induced impairment of neural vascular barrier and furthermore can be the targets of new therapeutic strategies for intractable neural diseases.

  3. [Impact of Rocky Desertification Treatment on Underground Water Chemistry and Dissolved Inorganic Carbon Isotope in Karst Areas].

    PubMed

    Xiao, Shi-zhen; Xiong, Kang-ning; Lan, Jia-cheng; Zhang, Hui; Yang, Long

    2015-05-01

    Five springs representing different land-use types and different karst rocky desertification treatment models were chosen at the Huajiang Karst Rocky Desertification Treatment Demonstration Site in Guanling-Zhenfeng Counties in Guizhou, to analyze the features of underground water chemistry and dissolved inorganic carbon isotopes (δ13C(DIC)) and reveal the effect of rocky desertification treatment on karstification and water quality. It was found that, the underground water type of the research area was HCO3-Ca; the water quality of the springs which were relatively less affected by human activities including Shuijingwan Spring (SJW) , Gebei Spring (GB), and Maojiawan Spring (MJW) was better than those relatively more affected by human activities including Diaojing Spring (DJ) and Tanjiazhai Spring (TJZ) , the main ion concentrations and electrical conductivity of which were higher; pH, SIc and pCO2 were sensitive to land-use types and rocky desertification treatment, which could be shown by the higher pH and SIc and lower pCO2 in MJW than those in the other four springs; (Ca(2+) + Mg2+)/HCO(3-) of SJW, MJW and GB were nearly 1:1, dominated by carbonate rock weathering by carbon acid, while the (Ca(2+) + Mg2+) of DJ and TJZ was much higher than HCO3-, suggesting that sulfate and nitrate might also dissolve carbonate rock because of the agricultural activities; δ13C(DIC) was lighter in wet season because of the higher biological activities; the average δ13C(DIC) was in the order of DJ (-12.79 per thousand) < SJW (-12.48 per thousand) < GB (-10.76 per thousand)) < MJW (-10.30 per thousand) < TJZ (-6.70 per thousand), which demonstrated that δ13C(DIC) would be heavier after rocky desertification and lighter after the rocky desertification are treated and controlled.

  4. Jefferson and Adams on the mind-body problem.

    PubMed

    Robinson, Daniel N

    2003-08-01

    Amidst the voluminous correspondence between Thomas Jefferson and John Adams are several letters pertaining to the material basis of mental life. These reveal in a most suggestive way the substantial differences between them. Well informed on prevailing scientific and philosophical perspectives, Jefferson and Adams used the issue to express their positions on the nature and limits of knowledge, the relative authority of scientific methods and speculations, and the larger question of human perfectibility. At the same time, their exchanges illuminate the prevailing and divergent perspectives on human psychology adopted by major leaders of thought in the New World.

  5. 77 FR 60004 - Culturally Significant Object Imported for Exhibition Determinations: “Wtewael's Adam and Eve”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-01

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Object Imported for Exhibition Determinations: ``Wtewael's Adam and Eve'' SUMMARY... object to be included in the exhibition ``Wtewael's Adam and Eve,'' imported from abroad for...

  6. CIG's Bullfrog No. 1 sets frac depth record for Rockies

    SciTech Connect

    Not Available

    1981-07-01

    The Rocky Mt. depth record for hydraulic fracturing has been pushed still deeper following treatment of a CIG exploration well in the Waltman deep field of Natrona County, Wyoming. Bullfrog No. 1, approx. 46 miles west of Casper in the Wind River Basin, was treated through 5 sets of perforations tapping 4 formations between 19,830 ft and 20,510 ft. The Bullfrog No. 1 was targeted for a total 157,500 lb proppant to be delivered in 2 stages - 15,000 lb 100 mesh sand, 15,000 lb 40/70 bauxite, and 48,750 lb 20/40 bauxite/stage - but the formation screened out late in the first stage. All the 100 mesh sand and 40/70 bauxite was delivered and 16,400 lb of 20/40 bauxite was placed in the formation. The screen-out left 13,600 lb of the 20/40 bauxite in the tubing. Despite the screen-out, at which point pressure at the wellhead reached 15,200 psi, the well cleaned up easily, production increased substantially, and CIG officials have termed the treatment a success.

  7. Rocky Mountain spotted fever: a clinician's dilemma.

    PubMed

    Masters, Edwin J; Olson, Gary S; Weiner, Scott J; Paddock, Christopher D

    2003-04-14

    Rocky Mountain spotted fever is still the most lethal tick-vectored illness in the United States. We examine the dilemmas facing the clinician who is evaluating the patient with possible Rocky Mountain spotted fever, with particular attention to the following 8 pitfalls in diagnosis and treatment: (1) waiting for a petechial rash to develop before diagnosis; (2) misdiagnosing as gastroenteritis; (3) discounting a diagnosis when there is no history of a tick bite; (4) using an inappropriate geographic exclusion; (5) using an inappropriate seasonal exclusion; (6) failing to treat on clinical suspicion; (7) failing to elicit an appropriate history; and (8) failing to treat with doxycycline. Early diagnosis and proper treatment save lives.

  8. The Role of ADAM9 in Tumor-Stromal Interactions in Breast Cancer

    DTIC Science & Technology

    2009-04-01

    endogenously express ADAM9-L and –S (Fig 1 ). Year two research focused on using isoform specific antibodies for immunocytochemistry in preparation for...migration. As outlined in the task 2 update, we have shown that the different isoforms of ADAM9 have opposing effects on breast cancer cell migration...both isoforms of ADAM-9, and our future work in this area will further define the relevant signaling pathways which participate in ADAM9 mediated

  9. Microwave solidification development for Rocky Flats waste

    SciTech Connect

    Dixon, D.; Erle, R.; Eschen, V.

    1994-04-01

    The Microwave Engineering Team at the Rocky Flats Plant has developed a production-scale system for the treatment of hazardous, radioactive, and mixed wastes using microwave energy. The system produces a vitreous final form which meets the acceptance criteria for shipment and disposal. The technology also has potential for application on various other waste streams from the public and private sectors. Technology transfer opportunities are being identified and pursued for commercialization of the microwave solidification technology.

  10. Status Update: Closing Rocky Flats by 2006

    SciTech Connect

    Tuor, N.; Schubert, A.

    2003-02-25

    Safely closing Rocky Flats by December 2006 is a goal shared by many: the State of Colorado, the communities surrounding the site, the U.S. Congress, the Department of Energy (DOE), Kaiser-Hill and its team of subcontractors, the site's employees and taxpayers across the country. This paper will: provide a status of the Closure Project to date; describe important accomplishments of the past year; describe some of the closure-enhancing technologies enabling acceleration; and discuss the remaining challenges ahead.

  11. THERMODYNAMIC LIMITS ON MAGNETODYNAMOS IN ROCKY EXOPLANETS

    SciTech Connect

    Gaidos, Eric; Conrad, Clinton P.; Manga, Michael; Hernlund, John

    2010-08-01

    To ascertain whether magnetic dynamos operate in rocky exoplanets more massive or hotter than the Earth, we developed a parametric model of a differentiated rocky planet and its thermal evolution. Our model reproduces the established properties of Earth's interior and magnetic field at the present time. When applied to Venus, assuming that planet lacks plate tectonics and has a dehydrated mantle with an elevated viscosity, the model shows that the dynamo shuts down or never operated. Our model predicts that at a fixed planet mass, dynamo history is sensitive to core size, but not to the initial inventory of long-lived, heat-producing radionuclides. It predicts that rocky planets larger than 2.5 Earth masses will not develop inner cores because the temperature-pressure slope of the iron solidus becomes flatter than that of the core adiabat. Instead, iron 'snow' will condense near or at the top of these cores, and the net transfer of latent heat upward will suppress convection and a dynamo. More massive planets can have anemic dynamos due to core cooling, but only if they have mobile lids (plate tectonics). The lifetime of these dynamos is shorter with increasing planet mass but longer with higher surface temperature. Massive Venus-like planets with stagnant lids and more viscous mantles will lack dynamos altogether. We identify two alternative sources of magnetic fields on rocky planets: eddy currents induced in the hot or molten upper layers of planets on very short-period orbits, and dynamos in the ionic conducting layers of 'ocean' planets with {approx}10% mass in an upper mantle of water (ice).

  12. Rocky Mountain futures: An ecological perspective

    USGS Publications Warehouse

    Baron, Jill S.

    2002-01-01

    The United Nations has proclaimed 2002 as the International Year of Mountains to increase international awareness of the global importance of mountain ecosystems. The case-based multidisciplinary approach of this book constitutes an important new model for understanding the implications of land-use practices and economic activity on mountains, and will serve a vital role in improving decisionmaking both in the Rocky Mountains and in other parts of the world that face similar challenges.

  13. Thermodynamic Limits on Magnetodynamos in Rocky Exoplanets

    NASA Astrophysics Data System (ADS)

    Gaidos, Eric; Conrad, Clinton P.; Manga, Michael; Hernlund, John

    2010-08-01

    To ascertain whether magnetic dynamos operate in rocky exoplanets more massive or hotter than the Earth, we developed a parametric model of a differentiated rocky planet and its thermal evolution. Our model reproduces the established properties of Earth's interior and magnetic field at the present time. When applied to Venus, assuming that planet lacks plate tectonics and has a dehydrated mantle with an elevated viscosity, the model shows that the dynamo shuts down or never operated. Our model predicts that at a fixed planet mass, dynamo history is sensitive to core size, but not to the initial inventory of long-lived, heat-producing radionuclides. It predicts that rocky planets larger than 2.5 Earth masses will not develop inner cores because the temperature-pressure slope of the iron solidus becomes flatter than that of the core adiabat. Instead, iron "snow" will condense near or at the top of these cores, and the net transfer of latent heat upward will suppress convection and a dynamo. More massive planets can have anemic dynamos due to core cooling, but only if they have mobile lids (plate tectonics). The lifetime of these dynamos is shorter with increasing planet mass but longer with higher surface temperature. Massive Venus-like planets with stagnant lids and more viscous mantles will lack dynamos altogether. We identify two alternative sources of magnetic fields on rocky planets: eddy currents induced in the hot or molten upper layers of planets on very short-period orbits, and dynamos in the ionic conducting layers of "ocean" planets with ~10% mass in an upper mantle of water (ice).

  14. Strain monitoring averts line failure in Rockies

    SciTech Connect

    Miller, B.; Bukovansky, M.

    1987-08-10

    The case history of a landslide in the U.S. Rocky Mountains shows that the potential for pipeline monitoring in geologically sensitive areas, those subject to landslides and subsidence, for example. A properly installed monitoring system monitored by the pipeline operator, Western Gas Supply Co. (West Gas), Denver, provided an early warning of increasing line strains. The problem was complicated by rugged topography which is described here. Stability analysis was the key technique utilized in the process.

  15. 1. NORTH AND EAST SIDES OF BUILDING 627. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. NORTH AND EAST SIDES OF BUILDING 627. VIEW TO SOUTHWEST. - Rocky Mountain Arsenal, Vehicle Maintenance Shop, 2130 feet North of Sixth Avenue; 300 feet West of B Street, Commerce City, Adams County, CO

  16. 4. INTERIOR OF BUILDING 313, SHOWING LABORATORY. VIEW TO EAST. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. INTERIOR OF BUILDING 313, SHOWING LABORATORY. VIEW TO EAST. - Rocky Mountain Arsenal, Laboratory Building, 510 feet South of December Seventh Avenue; 175 feet East of D Street, Commerce City, Adams County, CO

  17. 3. INTERIOR OF BUILDING 313, SHOWING LABORATORY. VIEW TO SOUTHEAST. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. INTERIOR OF BUILDING 313, SHOWING LABORATORY. VIEW TO SOUTHEAST. - Rocky Mountain Arsenal, Laboratory Building, 510 feet South of December Seventh Avenue; 175 feet East of D Street, Commerce City, Adams County, CO

  18. 6. INTERIOR OF BUILDING 313, SHOWING LABORATORY. VIEW TO NORTHWEST. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. INTERIOR OF BUILDING 313, SHOWING LABORATORY. VIEW TO NORTHWEST. - Rocky Mountain Arsenal, Laboratory Building, 510 feet South of December Seventh Avenue; 175 feet East of D Street, Commerce City, Adams County, CO

  19. 5. INTERIOR OF BUILDING 313, SHOWING LABORATORY. VIEW TO SOUTHWEST. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. INTERIOR OF BUILDING 313, SHOWING LABORATORY. VIEW TO SOUTHWEST. - Rocky Mountain Arsenal, Laboratory Building, 510 feet South of December Seventh Avenue; 175 feet East of D Street, Commerce City, Adams County, CO

  20. 7. INTERIOR OF BUILDING 313, SHOWING LABORATORY. VIEW TO NORTHEAST. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. INTERIOR OF BUILDING 313, SHOWING LABORATORY. VIEW TO NORTHEAST. - Rocky Mountain Arsenal, Laboratory Building, 510 feet South of December Seventh Avenue; 175 feet East of D Street, Commerce City, Adams County, CO

  1. 1. SOUTH AND WEST SIDES OF BUILDING 1707. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. SOUTH AND WEST SIDES OF BUILDING 1707. VIEW TO NORTHEAST. - Rocky Mountain Arsenal, Cooling Tower, 3500 feet South of Ninth Avenue; 470 feet East of Road Northwest-4, Commerce City, Adams County, CO

  2. 124. DETAIL OF NORTH PLANT CASE FILLING WAREHOUSE (BUILDING 1601). ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    124. DETAIL OF NORTH PLANT CASE FILLING WAREHOUSE (BUILDING 1601). VIEW TO SOUTH. - Rocky Mountain Arsenal, Bounded by Ninety-sixth Avenue & Fifty-sixth Avenue, Buckley Road, Quebec Street & Colorado Highway 2, Commerce City, Adams County, CO

  3. 3. SOUTH AND WEST SIDES OF BUILDING 543. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. SOUTH AND WEST SIDES OF BUILDING 543. VIEW TO NORTHEAST. - Rocky Mountain Arsenal, Maintenance Shop, 1050 feet South of December Seventh Avenue; 1550 feet East of D Street, Commerce City, Adams County, CO

  4. 2. SOUTH AND WEST SIDES OF BUILDING 459. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. SOUTH AND WEST SIDES OF BUILDING 459. VIEW TO NORTHEAST. - Rocky Mountain Arsenal, Acetylene Generator Building, 1650 feet South of December Seventh Avenue; 1050 feet East of D Street, Commerce City, Adams County, CO

  5. 1. EAST AND NORTH SIDES OF BUILDING 459. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. EAST AND NORTH SIDES OF BUILDING 459. VIEW TO SOUTHWEST. - Rocky Mountain Arsenal, Acetylene Generator Building, 1650 feet South of December Seventh Avenue; 1050 feet East of D Street, Commerce City, Adams County, CO

  6. 1. WEST AND SOUTH SIDES OF BUILDING 451. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. WEST AND SOUTH SIDES OF BUILDING 451. VIEW TO NORTHEAST. - Rocky Mountain Arsenal, Production Filling & Storage Building, 1050 feet South of December Seventh Avenue; 980 feet West of D Street, Commerce City, Adams County, CO

  7. 1. EAST AND NORTH SIDES OF BUILDING 543. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. EAST AND NORTH SIDES OF BUILDING 543. VIEW TO SOUTHWEST. - Rocky Mountain Arsenal, Maintenance Shop, 1050 feet South of December Seventh Avenue; 1550 feet East of D Street, Commerce City, Adams County, CO

  8. 2. WEST AND NORTH SIDES OF BUILDING 543. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. WEST AND NORTH SIDES OF BUILDING 543. VIEW TO SOUTHEAST. - Rocky Mountain Arsenal, Maintenance Shop, 1050 feet South of December Seventh Avenue; 1550 feet East of D Street, Commerce City, Adams County, CO

  9. 2. EAST AND SOUTH SIDES OF BUILDING 724. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. EAST AND SOUTH SIDES OF BUILDING 724. VIEW TO NORTHWEST. - Rocky Mountain Arsenal, Pesticide Incinerator-Precipitator, 260 feet South of December Seventh Avenue; 1840 feet East of D Street, Commerce City, Adams County, CO

  10. 3. SOUTH SIDE OF BUILDING 724. VIEW TO NORTH. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. SOUTH SIDE OF BUILDING 724. VIEW TO NORTH. - Rocky Mountain Arsenal, Pesticide Incinerator-Precipitator, 260 feet South of December Seventh Avenue; 1840 feet East of D Street, Commerce City, Adams County, CO

  11. 1. WEST AND NORTH SIDES OF BUILDING 724. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. WEST AND NORTH SIDES OF BUILDING 724. VIEW TO SOUTHEAST. - Rocky Mountain Arsenal, Pesticide Incinerator-Precipitator, 260 feet South of December Seventh Avenue; 1840 feet East of D Street, Commerce City, Adams County, CO

  12. 1. SOUTH AND WEST SIDES OF BUILDING 532. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. SOUTH AND WEST SIDES OF BUILDING 532. VIEW TO NORTHEAST. - Rocky Mountain Arsenal, Pesticide Filling & Storage Building, 390 feet South of December Seventh Avenue; 200 feet East of D Street, Commerce City, Adams County, CO

  13. 4. SOUTH AND EAST SIDES OF BUILDING 724. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. SOUTH AND EAST SIDES OF BUILDING 724. VIEW TO NORTHWEST. - Rocky Mountain Arsenal, Pesticide Incinerator-Precipitator, 260 feet South of December Seventh Avenue; 1840 feet East of D Street, Commerce City, Adams County, CO

  14. 2. NORTH AND EAST SIDES OF BUILDING 532. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. NORTH AND EAST SIDES OF BUILDING 532. VIEW TO SOUTHWEST. - Rocky Mountain Arsenal, Pesticide Filling & Storage Building, 390 feet South of December Seventh Avenue; 200 feet East of D Street, Commerce City, Adams County, CO

  15. 2. EAST REAR AND NORTH SIDE OF FIRE STATION. VIEW ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. EAST REAR AND NORTH SIDE OF FIRE STATION. VIEW TO SOUTHWEST. - Rocky Mountain Arsenal, Fire Station, 80 feet North of December Seventh Avenue; 120 feet East of D Street, Commerce City, Adams County, CO

  16. 1. WEST FRONT AND SOUTH SIDE OF FIRE STATION. VIEW ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. WEST FRONT AND SOUTH SIDE OF FIRE STATION. VIEW TO NORTHEAST. - Rocky Mountain Arsenal, Fire Station, 80 feet North of December Seventh Avenue; 120 feet East of D Street, Commerce City, Adams County, CO

  17. 1. WEST AND SOUTH SIDES OF BUILDING 472. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. WEST AND SOUTH SIDES OF BUILDING 472. VIEW TO NORTHEAST. - Rocky Mountain Arsenal, Thionyl Chloride Refridgeration Building, 1250 feet South of December Seventh Avenue; 1090 feet East of D Street, Commerce City, Adams County, CO

  18. 1. SOUTH AND EAST SIDES OF BUILDING 1614. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. SOUTH AND EAST SIDES OF BUILDING 1614. VIEW TO NORTHWEST. - Rocky Mountain Arsenal, General Purpose Warehouse, 1800 feet South of Ninth Avenue; 3150 feet East of D Street, Commerce City, Adams County, CO

  19. 1. SOUTH AND EAST SIDES OF BUILDING 1616. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. SOUTH AND EAST SIDES OF BUILDING 1616. VIEW TO NORTHWEST. - Rocky Mountain Arsenal, General Purpose Building, 2380 feet South of Ninth Avenue; 3390 feet East of D Street, Commerce City, Adams County, CO

  20. 1. SOUTH AND WEST SIDES OF BUILDING 1615. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. SOUTH AND WEST SIDES OF BUILDING 1615. VIEW TO NORTHEAST. - Rocky Mountain Arsenal, General Purpose Warehouse, 1980 feet South of Ninth Avenue; 3230 feet East of D Street, Commerce City, Adams County, CO

  1. 2. NORTH AND WEST SIDES OF BUILDING 1616. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. NORTH AND WEST SIDES OF BUILDING 1616. VIEW TO SOUTHEAST. - Rocky Mountain Arsenal, General Purpose Building, 2380 feet South of Ninth Avenue; 3390 feet East of D Street, Commerce City, Adams County, CO

  2. 1. NORTH AND EAST SIDES OF BUILDING 1702. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. NORTH AND EAST SIDES OF BUILDING 1702. VIEW TO SOUTHWEST. - Rocky Mountain Arsenal, General Purpose Warehouse, 3300 feet South of Ninth Avenue; 3350 feet East of D Street, Commerce City, Adams County, CO

  3. 2. WEST AND SOUTH SIDES OF BUILDING 365. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. WEST AND SOUTH SIDES OF BUILDING 365. VIEW TO NORTHEAST. - Rocky Mountain Arsenal, Explosives Blending Building, 2180 feet South of December Seventh Avenue; 900 feet West of D Street, Commerce City, Adams County, CO

  4. 1. EAST AND NORTH SIDES OF BUILDING 365. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. EAST AND NORTH SIDES OF BUILDING 365. VIEW TO SOUTHWEST. - Rocky Mountain Arsenal, Explosives Blending Building, 2180 feet South of December Seventh Avenue; 900 feet West of D Street, Commerce City, Adams County, CO

  5. 1. EAST AND SOUTH SIDES OF BUILDING 1613. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. EAST AND SOUTH SIDES OF BUILDING 1613. VIEW TO NORTHWEST. - Rocky Mountain Arsenal, Storage Building-Explosive Unpacking, 510 feet South of Road EW-3; adjacent to Road NS-4, Commerce City, Adams County, CO

  6. 1. SOUTH AND WEST SIDES OF BUILDING 112. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. SOUTH AND WEST SIDES OF BUILDING 112. VIEW TO NORTHEAST. - Rocky Mountain Arsenal, Communication Building, 75 feet North of December Seventh Avenue; 2400 feet East of C Street, Commerce City, Adams County, CO

  7. 1. SOUTH AND EAST SIDES OF BUILDING 1605. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. SOUTH AND EAST SIDES OF BUILDING 1605. VIEW TO NORTHWEST. - Rocky Mountain Arsenal, Fuse Detonater Magazine, 166 feet South of Ninth Avenue; 2500 feet East of D Street, Commerce City, Adams County, CO

  8. 1. SOUTH AND EAST SIDES OF BUILDING 422. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. SOUTH AND EAST SIDES OF BUILDING 422. VIEW TO NORTHWEST. - Rocky Mountain Arsenal, Administration-Laboratory- Change House-Bomb Rail, 420 feet South of December Seventh Avenue; 530 feet West of D Street, Commerce City, Adams County, CO

  9. 2. NORTH AND WEST SIDES OF BUILDING 422. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. NORTH AND WEST SIDES OF BUILDING 422. VIEW TO SOUTHEAST. - Rocky Mountain Arsenal, Administration-Laboratory- Change House-Bomb Rail, 420 feet South of December Seventh Avenue; 530 feet West of D Street, Commerce City, Adams County, CO

  10. 7. INTERIOR OF BUILDING 242, SHOWING GANTRY HOIST IN FOREGROUND. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. INTERIOR OF BUILDING 242, SHOWING GANTRY HOIST IN FOREGROUND. VIEW TO SOUTHWEST. - Rocky Mountain Arsenal, Chlorine Production Cell Building, 405 feet South of December Seventh Avenue; 330 feet West of D Street, Commerce City, Adams County, CO

  11. 3. WEST AND SOUTH SIDES OF BUILDING 251. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. WEST AND SOUTH SIDES OF BUILDING 251. VIEW TO NORTHEAST. - Rocky Mountain Arsenal, Chlorine Evaporator & Storage Building, 800 feet South of December Seventh Avenue; 600 feet West of D Street, Commerce City, Adams County, CO

  12. 8. INTERIOR OF BUILDING 242, SHOWING STRUCTURAL COLUMNS AND ROOF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. INTERIOR OF BUILDING 242, SHOWING STRUCTURAL COLUMNS AND ROOF TRUSSES. VIEW TO SOUTH. - Rocky Mountain Arsenal, Chlorine Production Cell Building, 405 feet South of December Seventh Avenue; 330 feet West of D Street, Commerce City, Adams County, CO

  13. 2. NORTH AND EAST SIDES OF BUILDING 251. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. NORTH AND EAST SIDES OF BUILDING 251. VIEW TO SOUTHWEST. - Rocky Mountain Arsenal, Chlorine Evaporator & Storage Building, 800 feet South of December Seventh Avenue; 600 feet West of D Street, Commerce City, Adams County, CO

  14. 1. EAST AND NORTH SIDES OF BUILDING 251. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. EAST AND NORTH SIDES OF BUILDING 251. VIEW TO SOUTHWEST. - Rocky Mountain Arsenal, Chlorine Evaporator & Storage Building, 800 feet South of December Seventh Avenue; 600 feet West of D Street, Commerce City, Adams County, CO

  15. 4. NORTH AND WEST SIDES OF BUILDING 242. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. NORTH AND WEST SIDES OF BUILDING 242. VIEW TO SOUTHEAST. - Rocky Mountain Arsenal, Chlorine Production Cell Building, 405 feet South of December Seventh Avenue; 330 feet West of D Street, Commerce City, Adams County, CO

  16. 3. SOUTH AND WEST SIDES OF BUILDING 242 (RIGHT) AND ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. SOUTH AND WEST SIDES OF BUILDING 242 (RIGHT) AND 243 (LEFT). VIEW TO NORTHEAST. - Rocky Mountain Arsenal, Chlorine Production Cell Building, 405 feet South of December Seventh Avenue; 330 feet West of D Street, Commerce City, Adams County, CO

  17. 6. WEST AND SOUTH SIDES OF BUILDING 243. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. WEST AND SOUTH SIDES OF BUILDING 243. VIEW TO NORTHEAST. - Rocky Mountain Arsenal, Chlorine Production Cell Building, 405 feet South of December Seventh Avenue; 330 feet West of D Street, Commerce City, Adams County, CO

  18. 5. NORTH AND WEST SIDES OF BUILDING 243. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. NORTH AND WEST SIDES OF BUILDING 243. VIEW TO SOUTHEAST. - Rocky Mountain Arsenal, Chlorine Production Cell Building, 405 feet South of December Seventh Avenue; 330 feet West of D Street, Commerce City, Adams County, CO

  19. 80. SOUTH PLANT INCINERATOR/PRECIPITATOR (BUILDING 724), CENTER. VIEW TO NORTH. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    80. SOUTH PLANT INCINERATOR/PRECIPITATOR (BUILDING 724), CENTER. VIEW TO NORTH. - Rocky Mountain Arsenal, Bounded by Ninety-sixth Avenue & Fifty-sixth Avenue, Buckley Road, Quebec Street & Colorado Highway 2, Commerce City, Adams County, CO

  20. 1. WEST AND NORTH SIDES OF BUILDING 1506. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. WEST AND NORTH SIDES OF BUILDING 1506. VIEW TO SOUTHEAST. - Rocky Mountain Arsenal, Sarin Storage Building, 3320 feet South of Ninth Avenue; 30 feet East of Road NS-4, Commerce City, Adams County, CO

  1. 11. INTERIOR DETAIL OF FIRST FLOOR CONTROL PANEL IN BUILDING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. INTERIOR DETAIL OF FIRST FLOOR CONTROL PANEL IN BUILDING 1501. VIEW TO NORTH. - Rocky Mountain Arsenal, Sarin Manufacturing Building, 3350 feet South of Ninth Avenue; 250 feet East of Road NS-4, Commerce City, Adams County, CO

  2. 3. SOUTH AND WEST SIDES OF BUILDING 1501. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. SOUTH AND WEST SIDES OF BUILDING 1501. VIEW TO NORTHEAST. - Rocky Mountain Arsenal, Sarin Manufacturing Building, 3350 feet South of Ninth Avenue; 250 feet East of Road NS-4, Commerce City, Adams County, CO

  3. 4. SOUTH AND EAST SIDES OF BUILDING 1501. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. SOUTH AND EAST SIDES OF BUILDING 1501. VIEW TO NORTHWEST. - Rocky Mountain Arsenal, Sarin Manufacturing Building, 3350 feet South of Ninth Avenue; 250 feet East of Road NS-4, Commerce City, Adams County, CO

  4. 1. NORTH AND WEST SIDES OF BUILDING 1501. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. NORTH AND WEST SIDES OF BUILDING 1501. VIEW TO SOUTHEAST. - Rocky Mountain Arsenal, Sarin Manufacturing Building, 3350 feet South of Ninth Avenue; 250 feet East of Road NS-4, Commerce City, Adams County, CO

  5. 8. FIRST FLOOR CENTER HALLWAY IN BUILDING 1501. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. FIRST FLOOR CENTER HALLWAY IN BUILDING 1501. VIEW TO WEST. - Rocky Mountain Arsenal, Sarin Manufacturing Building, 3350 feet South of Ninth Avenue; 250 feet East of Road NS-4, Commerce City, Adams County, CO

  6. 5. EAST AND NORTH SIDES OF BUILDING 1501. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. EAST AND NORTH SIDES OF BUILDING 1501. VIEW TO SOUTHWEST. - Rocky Mountain Arsenal, Sarin Manufacturing Building, 3350 feet South of Ninth Avenue; 250 feet East of Road NS-4, Commerce City, Adams County, CO

  7. 7. DETAIL OF WEST SIDE OF BUILDING 1501. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. DETAIL OF WEST SIDE OF BUILDING 1501. VIEW TO EAST. - Rocky Mountain Arsenal, Sarin Manufacturing Building, 3350 feet South of Ninth Avenue; 250 feet East of Road NS-4, Commerce City, Adams County, CO

  8. 10. INTERIOR DETAIL OF FIRST FLOOR CONTROL PANEL IN BUILDING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. INTERIOR DETAIL OF FIRST FLOOR CONTROL PANEL IN BUILDING 1501. VIEW TO NORTHEAST. - Rocky Mountain Arsenal, Sarin Manufacturing Building, 3350 feet South of Ninth Avenue; 250 feet East of Road NS-4, Commerce City, Adams County, CO

  9. 6. NORTH AND EAST SIDES OF BUILDING 1501. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. NORTH AND EAST SIDES OF BUILDING 1501. VIEW TO SOUTHWEST. - Rocky Mountain Arsenal, Sarin Manufacturing Building, 3350 feet South of Ninth Avenue; 250 feet East of Road NS-4, Commerce City, Adams County, CO

  10. 9. INTERIOR DETAIL OF FIRST FLOOR CONTROL PANEL IN BUILDING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. INTERIOR DETAIL OF FIRST FLOOR CONTROL PANEL IN BUILDING 1501. VIEW TO NORTHWEST. - Rocky Mountain Arsenal, Sarin Manufacturing Building, 3350 feet South of Ninth Avenue; 250 feet East of Road NS-4, Commerce City, Adams County, CO

  11. 12. INTERIOR DETAIL OF REAR OF FIRST FLOOR CONTROL PANEL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. INTERIOR DETAIL OF REAR OF FIRST FLOOR CONTROL PANEL IN BUILDING 1501. VIEW TO WEST - Rocky Mountain Arsenal, Sarin Manufacturing Building, 3350 feet South of Ninth Avenue; 250 feet East of Road NS-4, Commerce City, Adams County, CO

  12. 3. GENERAL VIEW OF SETTING OF TANK 0745C (ON LEFT). ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. GENERAL VIEW OF SETTING OF TANK 0745C (ON LEFT). TANK 0745B IS ON RIGHT. VIEW TO SOUTHWEST. - Rocky Mountain Arsenal, Gasoline Storage Tank, December Seventh Avenue & D Street, Commerce City, Adams County, CO

  13. 1. GENERAL VIEW OF SETTING OF TANK 0745C (ON RIGHT). ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. GENERAL VIEW OF SETTING OF TANK 0745C (ON RIGHT). TANKS 0745A, AND O745B ARE ON LEFT. VIEW TO NORTHEAST. - Rocky Mountain Arsenal, Gasoline Storage Tank, December Seventh Avenue & D Street, Commerce City, Adams County, CO

  14. 2. GENERAL VIEW OF SETTING OF TANK 0745C (ON LEFT). ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. GENERAL VIEW OF SETTING OF TANK 0745C (ON LEFT). TANKS 0745A AND 0745B ARE ON RIGHT. VIEW TO NORTHWEST. - Rocky Mountain Arsenal, Gasoline Storage Tank, December Seventh Avenue & D Street, Commerce City, Adams County, CO

  15. 1. EAST AND NORTH SIDES OF BUILDING 329. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. EAST AND NORTH SIDES OF BUILDING 329. VIEW TO SOUTHWEST. - Rocky Mountain Arsenal, Gasoline Pump Building, 1300 feet South of December Seventh Avenue; 840 feet West of D Street, Commerce City, Adams County, CO

  16. 2. OVERALL VIEW OF SOUTH PLANT FROM SHELL CHEMICAL STORAGE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. OVERALL VIEW OF SOUTH PLANT FROM SHELL CHEMICAL STORAGE TANK. VIEW TO NORTHWEST. - Rocky Mountain Arsenal, Bounded by Ninety-sixth Avenue & Fifty-sixth Avenue, Buckley Road, Quebec Street & Colorado Highway 2, Commerce City, Adams County, CO

  17. 131. NORTH PLANT TANK CHEMICAL STORAGE TANKS FROM GB MANUFACTURING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    131. NORTH PLANT TANK CHEMICAL STORAGE TANKS FROM GB MANUFACTURING PLANT. VIEW TO SOUTHEAST. - Rocky Mountain Arsenal, Bounded by Ninety-sixth Avenue & Fifty-sixth Avenue, Buckley Road, Quebec Street & Colorado Highway 2, Commerce City, Adams County, CO

  18. 65. SOUTH PLANT CHEMICAL STORAGE TANKS, WITH SECONDARY CONTAINMENT BERM ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    65. SOUTH PLANT CHEMICAL STORAGE TANKS, WITH SECONDARY CONTAINMENT BERM IN FOREGROUND. VIEW TO NORTHEAST. - Rocky Mountain Arsenal, Bounded by Ninety-sixth Avenue & Fifty-sixth Avenue, Buckley Road, Quebec Street & Colorado Highway 2, Commerce City, Adams County, CO

  19. 1. NORTH AND WEST SIDES OF BUILDING 728 FROM CHEMICAL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. NORTH AND WEST SIDES OF BUILDING 728 FROM CHEMICAL STORAGE TANK. VIEW TO SOUTHEAST. - Rocky Mountain Arsenal, Mustard Filling & Storage Building, 280 feet South of December Seventh Avenue; 2130 feet East of D Street, Commerce City, Adams County, CO

  20. 66. SOUTH PLANT CHEMICAL STORAGE TANKS. VIEW TO NORTHEAST. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    66. SOUTH PLANT CHEMICAL STORAGE TANKS. VIEW TO NORTHEAST. - Rocky Mountain Arsenal, Bounded by Ninety-sixth Avenue & Fifty-sixth Avenue, Buckley Road, Quebec Street & Colorado Highway 2, Commerce City, Adams County, CO

  1. 64. SOUTH PLANT PROCESS PIPING, CHEMICAL STORAGE TANKS AND BUILDINGS. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    64. SOUTH PLANT PROCESS PIPING, CHEMICAL STORAGE TANKS AND BUILDINGS. VIEW TO NORTHEAST. - Rocky Mountain Arsenal, Bounded by Ninety-sixth Avenue & Fifty-sixth Avenue, Buckley Road, Quebec Street & Colorado Highway 2, Commerce City, Adams County, CO

  2. 78. DETAIL OF SOUTH PLANT MAILBOX, WITH CHEMICAL STORAGE TANKS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    78. DETAIL OF SOUTH PLANT MAILBOX, WITH CHEMICAL STORAGE TANKS IN BACKGROUND. VIEW TO SOUTHWEST. - Rocky Mountain Arsenal, Bounded by Ninety-sixth Avenue & Fifty-sixth Avenue, Buckley Road, Quebec Street & Colorado Highway 2, Commerce City, Adams County, CO

  3. 86. DETAIL OF SOUTH PLANT CHEMICAL STORAGE TANKS. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    86. DETAIL OF SOUTH PLANT CHEMICAL STORAGE TANKS. VIEW TO EAST. - Rocky Mountain Arsenal, Bounded by Ninety-sixth Avenue & Fifty-sixth Avenue, Buckley Road, Quebec Street & Colorado Highway 2, Commerce City, Adams County, CO

  4. 2. OVERHEAD CHEMICAL PROCESS PIPING BETWEEN BUILDINGS 422, ON RIGHT, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. OVERHEAD CHEMICAL PROCESS PIPING BETWEEN BUILDINGS 422, ON RIGHT, AND 431, ON LEFT. - Rocky Mountain Arsenal, Crude Mustard & Aldrin Manufacturing, 1200 feet South of December Seventh Avenue; 600 feet East of D Street, Commerce City, Adams County, CO

  5. 72. SOUTH PLANT SHELL OIL COMPANY COMPLEX, FROM CHEMICAL STORAGE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    72. SOUTH PLANT SHELL OIL COMPANY COMPLEX, FROM CHEMICAL STORAGE TANK. VIEW TO WEST. - Rocky Mountain Arsenal, Bounded by Ninety-sixth Avenue & Fifty-sixth Avenue, Buckley Road, Quebec Street & Colorado Highway 2, Commerce City, Adams County, CO

  6. 84. SOUTH PLANT CHEMICAL STORAGE TANKS AND FILLING STATION. VIEW ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    84. SOUTH PLANT CHEMICAL STORAGE TANKS AND FILLING STATION. VIEW TO NORTHWEST. - Rocky Mountain Arsenal, Bounded by Ninety-sixth Avenue & Fifty-sixth Avenue, Buckley Road, Quebec Street & Colorado Highway 2, Commerce City, Adams County, CO

  7. 6. DETAIL OF SOUTH SIDE OF BUILDING 514. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. DETAIL OF SOUTH SIDE OF BUILDING 514. VIEW TO NORTHWEST. - Rocky Mountain Arsenal, Lewisite Reactor & Distilled Mustard Distillation Building, 420 feet South of December Seventh Avenue; 1070 feet East of D Street, Commerce City, Adams County, CO

  8. 3. SOUTH AND WEST SIDES OF BUILDING 514. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. SOUTH AND WEST SIDES OF BUILDING 514. VIEW TO NORTHEAST. - Rocky Mountain Arsenal, Lewisite Reactor & Distilled Mustard Distillation Building, 420 feet South of December Seventh Avenue; 1070 feet East of D Street, Commerce City, Adams County, CO

  9. 1. NORTH AND EAST SIDES OF BUILDING 514. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. NORTH AND EAST SIDES OF BUILDING 514. VIEW TO SOUTHWEST. - Rocky Mountain Arsenal, Lewisite Reactor & Distilled Mustard Distillation Building, 420 feet South of December Seventh Avenue; 1070 feet East of D Street, Commerce City, Adams County, CO

  10. 4. EAST SIDE OF BUILDING 514. VIEW TO WEST. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. EAST SIDE OF BUILDING 514. VIEW TO WEST. - Rocky Mountain Arsenal, Lewisite Reactor & Distilled Mustard Distillation Building, 420 feet South of December Seventh Avenue; 1070 feet East of D Street, Commerce City, Adams County, CO

  11. 3. NORTH AND EAST SIDES OF BUILDING 515. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. NORTH AND EAST SIDES OF BUILDING 515. VIEW TO SOUTHWEST. - Rocky Mountain Arsenal, Crude Mustard Distillation Building, 550 feet South of December Seventh Avenue; 400 feet East of D Street, Commerce City, Adams County, CO

  12. 5. SOUTH SIDE OF BUILDING 514. VIEW TO NORTHWEST. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. SOUTH SIDE OF BUILDING 514. VIEW TO NORTHWEST. - Rocky Mountain Arsenal, Lewisite Reactor & Distilled Mustard Distillation Building, 420 feet South of December Seventh Avenue; 1070 feet East of D Street, Commerce City, Adams County, CO

  13. 4. WEST AND NORTH SIDES OF BUILDING 515. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. WEST AND NORTH SIDES OF BUILDING 515. VIEW TO SOUTHEAST. - Rocky Mountain Arsenal, Crude Mustard Distillation Building, 550 feet South of December Seventh Avenue; 400 feet East of D Street, Commerce City, Adams County, CO

  14. 2. WEST AND NORTH SIDES OF BUILDING 514. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. WEST AND NORTH SIDES OF BUILDING 514. VIEW TO SOUTHEAST. - Rocky Mountain Arsenal, Lewisite Reactor & Distilled Mustard Distillation Building, 420 feet South of December Seventh Avenue; 1070 feet East of D Street, Commerce City, Adams County, CO

  15. 1. SOUTH SIDE OF BUILDING 515. VIEW TO NORTH. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. SOUTH SIDE OF BUILDING 515. VIEW TO NORTH. - Rocky Mountain Arsenal, Crude Mustard Distillation Building, 550 feet South of December Seventh Avenue; 400 feet East of D Street, Commerce City, Adams County, CO

  16. 2. WEST AND SOUTH SIDES OF BUILDING 515. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. WEST AND SOUTH SIDES OF BUILDING 515. VIEW TO NORTHEAST. - Rocky Mountain Arsenal, Crude Mustard Distillation Building, 550 feet South of December Seventh Avenue; 400 feet East of D Street, Commerce City, Adams County, CO

  17. 8. SOUTH PLANT SHELL OIL COMPANY FACILITIES, WITH PIPELINE PEDESTALS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. SOUTH PLANT SHELL OIL COMPANY FACILITIES, WITH PIPELINE PEDESTALS IN FOREGROUND. VIEW TO SOUTHWEST. - Rocky Mountain Arsenal, Bounded by Ninety-sixth Avenue & Fifty-sixth Avenue, Buckley Road, Quebec Street & Colorado Highway 2, Commerce City, Adams County, CO

  18. 7. NORTH WING OF BUILDING 741/742. VIEW TO WEST. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. NORTH WING OF BUILDING 741/742. VIEW TO WEST. - Rocky Mountain Arsenal, Refrigeration Napalm & Incendiary Bomb Warehouse-Bomb Filling, 825 feet South of December Seventh Avenue; 2425 feet East of D Street, Commerce City, Adams County, CO

  19. 8. NORTH WING OF BUILDING 741/742. VIEW TO SOUTHWEST. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. NORTH WING OF BUILDING 741/742. VIEW TO SOUTHWEST. - Rocky Mountain Arsenal, Refrigeration Napalm & Incendiary Bomb Warehouse-Bomb Filling, 825 feet South of December Seventh Avenue; 2425 feet East of D Street, Commerce City, Adams County, CO

  20. 1. SOUTH AND WEST SIDES OF BUILDING 254. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. SOUTH AND WEST SIDES OF BUILDING 254. VIEW TO NORTHEAST. - Rocky Mountain Arsenal, Caustic Fusion Building, 450 feet South of December Seventh Avenue; 900 feet West of D Street, Commerce City, Adams County, CO

  1. 2. EAST AND NORTH SIDES OF BUILDING 254. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. EAST AND NORTH SIDES OF BUILDING 254. VIEW TO SOUTHWEST. - Rocky Mountain Arsenal, Caustic Fusion Building, 450 feet South of December Seventh Avenue; 900 feet West of D Street, Commerce City, Adams County, CO

  2. 3. INTERIOR DETAIL OF BOILERS IN BUILDING 1602. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. INTERIOR DETAIL OF BOILERS IN BUILDING 1602. VIEW TO NORTHWEST. - Rocky Mountain Arsenal, Ammunition Demolition Building-Paint Storage, 40 feet North of Road EW-2; 2900 feet East of D Street, Commerce City, Adams County, CO

  3. 1. EAST AND NORTH SIDES OF BUILDING 1602. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. EAST AND NORTH SIDES OF BUILDING 1602. VIEW TO SOUTHWEST. - Rocky Mountain Arsenal, Ammunition Demolition Building-Paint Storage, 40 feet North of Road EW-2; 2900 feet East of D Street, Commerce City, Adams County, CO

  4. 6. INTERIOR OF REAR SECTION OF BUILDING 431. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. INTERIOR OF REAR SECTION OF BUILDING 431. VIEW TO NORTHEAST. - Rocky Mountain Arsenal, Ethylene Dryer-Compressor Refrigeration Building, December Seventh Avenue & D Street, Commerce City, Adams County, CO

  5. 61. SOUTH PLANT ETHYLENE GENERATOR BUILDING, WITH EMERGENCY SHOWER AT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    61. SOUTH PLANT ETHYLENE GENERATOR BUILDING, WITH EMERGENCY SHOWER AT LEFT FOREGROUND. VIEW TO WEST. - Rocky Mountain Arsenal, Bounded by Ninety-sixth Avenue & Fifty-sixth Avenue, Buckley Road, Quebec Street & Colorado Highway 2, Commerce City, Adams County, CO

  6. 5. INTERIOR OF FRONT SECTION OF BUILDING 431. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. INTERIOR OF FRONT SECTION OF BUILDING 431. VIEW TO EAST. - Rocky Mountain Arsenal, Ethylene Dryer-Compressor Refrigeration Building, December Seventh Avenue & D Street, Commerce City, Adams County, CO

  7. 24. INTERIOR DETAIL OF BUILDING 1607, SHOWING BOMBS AND CRATES. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    24. INTERIOR DETAIL OF BUILDING 1607, SHOWING BOMBS AND CRATES. VIEW TO SOUTHWEST. - Rocky Mountain Arsenal, Cluster Bomb Assembly-Filling-Storage Building, 3500 feet South of Ninth Avenue; 2870 feet East of D Street, Commerce City, Adams County, CO

  8. 12. INTERIOR DETAIL OF ELECTRICAL PANEL IN BUILDING 1606. VIEW ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. INTERIOR DETAIL OF ELECTRICAL PANEL IN BUILDING 1606. VIEW TO NORTH. - Rocky Mountain Arsenal, Cluster Bomb Assembly-Filling-Storage Building, 3500 feet South of Ninth Avenue; 2870 feet East of D Street, Commerce City, Adams County, CO

  9. 1. NORTH AND WEST SIDES OF BUILDING 346. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. NORTH AND WEST SIDES OF BUILDING 346. VIEW TO SOUTHEAST. - Rocky Mountain Arsenal, Storage Warehouse for Incendiary Clusters, 1659 feet South of December Seventh Avenue; 2060 feet West of D Street, Commerce City, Adams County, CO

  10. 14. INTERIOR DETAIL OF CONTROL PANEL IN BUILDING 1606. VIEW ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. INTERIOR DETAIL OF CONTROL PANEL IN BUILDING 1606. VIEW TO SOUTH. - Rocky Mountain Arsenal, Cluster Bomb Assembly-Filling-Storage Building, 3500 feet South of Ninth Avenue; 2870 feet East of D Street, Commerce City, Adams County, CO

  11. 16. INTERIOR DETAIL OF CONTROL PANEL IN BUILDING 1606. VIEW ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. INTERIOR DETAIL OF CONTROL PANEL IN BUILDING 1606. VIEW TO SOUTHWEST. - Rocky Mountain Arsenal, Cluster Bomb Assembly-Filling-Storage Building, 3500 feet South of Ninth Avenue; 2870 feet East of D Street, Commerce City, Adams County, CO

  12. 17. INTERIOR DETAIL OF CONTROL PANEL IN BUILDING 1606. VIEW ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    17. INTERIOR DETAIL OF CONTROL PANEL IN BUILDING 1606. VIEW TO SOUTH. - Rocky Mountain Arsenal, Cluster Bomb Assembly-Filling-Storage Building, 3500 feet South of Ninth Avenue; 2870 feet East of D Street, Commerce City, Adams County, CO

  13. 26. BOMBS IN CRATE IN BUILDING 1607. VIEW TO NORTHWEST. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    26. BOMBS IN CRATE IN BUILDING 1607. VIEW TO NORTHWEST. - Rocky Mountain Arsenal, Cluster Bomb Assembly-Filling-Storage Building, 3500 feet South of Ninth Avenue; 2870 feet East of D Street, Commerce City, Adams County, CO

  14. 15. INTERIOR DETAIL OF CONTROL PANEL IN BUILDING 1606. VIEW ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    15. INTERIOR DETAIL OF CONTROL PANEL IN BUILDING 1606. VIEW TO NORTH. - Rocky Mountain Arsenal, Cluster Bomb Assembly-Filling-Storage Building, 3500 feet South of Ninth Avenue; 2870 feet East of D Street, Commerce City, Adams County, CO

  15. Atmospheric deposition maps for the Rocky Mountains

    USGS Publications Warehouse

    Nanus, L.; Campbell, D.H.; Ingersoll, G.P.; Clow, D.W.; Mast, M.A.

    2003-01-01

    Variability in atmospheric deposition across the Rocky Mountains is influenced by elevation, slope, aspect, and precipitation amount and by regional and local sources of air pollution. To improve estimates of deposition in mountainous regions, maps of average annual atmospheric deposition loadings of nitrate, sulfate, and acidity were developed for the Rocky Mountains by using spatial statistics. A parameter-elevation regressions on independent slopes model (PRISM) was incorporated to account for variations in precipitation amount over mountainous regions. Chemical data were obtained from the National Atmospheric Deposition Program/National Trends Network and from annual snowpack surveys conducted by the US Geological Survey and National Park Service, in cooperation with other Federal, State and local agencies. Surface concentration maps were created by ordinary kriging in a geographic information system, using a local trend and mathematical model to estimate the spatial variance. Atmospheric-deposition maps were constructed at 1-km resolution by multiplying surface concentrations from the kriged grid and estimates of precipitation amount from the PRISM model. Maps indicate an increasing spatial trend in concentration and deposition of the modeled constituents, particularly nitrate and sulfate, from north to south throughout the Rocky Mountains and identify hot-spots of atmospheric deposition that result from combined local and regional sources of air pollution. Highest nitrate (2.5-3.0kg/ha N) and sulfate (10.0-12.0kg/ha SO4) deposition is found in northern Colorado.

  16. A new reference section for palynostratigraphic zonation of Paleocene rocks in the Rocky Mountain region

    USGS Publications Warehouse

    Nichols, D.J.; Flores, R.M.

    2006-01-01

    A biostratigraphic (palynostratigraphic) zonation of Paleocene rocks was established in the northeastern Wind River Basin near Waltman, Natrona County, Wyoming, in 1978 and subsequently applied extensively by various workers throughout the Rocky Mountain region. Because the original study on which the zonation was based was proprietary, precise details about the locations of the two reference sections and the samples on which the zonation was based were not published and are no longer retrievable. Therefore, it is useful (although not required) to designate formally a new reference section for the Paleocene biozones. Accordingly, exposures of Paleocene and associated strata within and west of the Castle Gardens Petroglyph Site in Fremont County, Wyoming, in the east-central part of the Wind River Basin, were selected for this purpose. At this location, composite stratigraphic sections encompassing 740 m of strata were measured, described, and sampled. Productive samples yielded characteristic Maastrichtian palynomorphs from the lower part of the sampled interval and diagnostic species of the six palynological biozones zones widely known as P1 (lower Paleocene) through P6 (upper Paleocene), through an interval of about 580 m. The Paleocene biozones are present in the same consistent stratigraphic order in the Castle Gardens area as observed in the 1978 study and subsequent studies throughout the Rocky Mountain region. In accordance with the North American Stratigraphic Code, the historical background is presented; intent to establish the Castle Gardens reference section is declared; the category, rank, and formal names of biostratigraphic units within it are specified; and the features of the biozonation are described, including biozone boundaries, ages, and regional relations. Occurrences of biostratigraphically significant palynological species within each biozone in the reference section are tabulated, and presence of these and other species in correlative

  17. Public health assessment for Adams County Quincy landfills 2 and 3, Quincy, Adams County, Illinois, Region 5. Cerclis No. ILD980607055. Final report

    SciTech Connect

    1999-09-28

    Since the completion of remedial activities at the site, the Quincy landfill 2 and 3 site poses no apparent public health hazard. No one is currently exposed to contamination at the site. Any past exposure would not have been at levels of health concern. Based on current conditions, IDPH recommends that the Quincy Landfill 2 and 3 participating respondents group: Encourage the homeowner 1/2 mile west of the site to connect to Mill Creek Public Water supply and to seal the private well to eliminate possible exposure to site-related contaminants in groundwater; provide groundwater containment and treatment if groundwater cleanup levels are not met and maintained; continue proper maintenance of the leachate collection system and tank; maintain the landfill cap, particularly to address any erosion that occurs; and maintain a 6-foot-high security fence around the perimeter of the site to prevent trespassing.

  18. Father Knows Best: Using Adam Smith to Teach Transactions Costs

    ERIC Educational Resources Information Center

    Dupont, Brandon

    2014-01-01

    Adam Smith's moral philosophy can be used to introduce economics students to the important idea of transactions costs. The author provides a brief background in this article to Smith's moral philosophy and connects it to the costs of transacting in a way that fits easily into the standard principles of microeconomics classroom. By doing…

  19. The ADaptation and Anticipation Model (ADAM) of sensorimotor synchronization

    PubMed Central

    van der Steen, M. C. (Marieke); Keller, Peter E.

    2013-01-01

    A constantly changing environment requires precise yet flexible timing of movements. Sensorimotor synchronization (SMS)—the temporal coordination of an action with events in a predictable external rhythm—is a fundamental human skill that contributes to optimal sensory-motor control in daily life. A large body of research related to SMS has focused on adaptive error correction mechanisms that support the synchronization of periodic movements (e.g., finger taps) with events in regular pacing sequences. The results of recent studies additionally highlight the importance of anticipatory mechanisms that support temporal prediction in the context of SMS with sequences that contain tempo changes. To investigate the role of adaptation and anticipatory mechanisms in SMS we introduce ADAM: an ADaptation and Anticipation Model. ADAM combines reactive error correction processes (adaptation) with predictive temporal extrapolation processes (anticipation) inspired by the computational neuroscience concept of internal models. The combination of simulations and experimental manipulations based on ADAM creates a novel and promising approach for exploring adaptation and anticipation in SMS. The current paper describes the conceptual basis and architecture of ADAM. PMID:23772211

  20. What Ever Happened to . . . John Adams High School?

    ERIC Educational Resources Information Center

    Doremus, Richard R.

    1981-01-01

    First in a series, this article describes the rise and fall of John Adams High School, an experimental school in Portland (Oregon) that was recently closed after 12 years of operation. The experiences of those who tried to make the experiment work may help others interested in educational innovation. (WD)

  1. "The Adams Chronicles" and the American History Survey

    ERIC Educational Resources Information Center

    Rollins, Richard M.

    1977-01-01

    Film documentaries can be a valuable addition to introductory American history courses. Using "The Adams Chronicles" as an example, the author identifies flaws in the film and then explains how careful planning and analysis of the video and printed programs enabled him to incorporate it effectively into a freshman-level survey course at Ohio State…

  2. Adam Smith and the Moral Economy of the Classroom System.

    ERIC Educational Resources Information Center

    Hamilton, D.

    1980-01-01

    Traces the development of mass schooling to its origins in 19th-century Glasgow. Its importance as an intellectual and economic center enabled Glasgow to invent a solution to the problem of urban schooling, while the association of scholars like Adam Smith with Glasgow University made Scottish educational theories acceptable around the world. (DB)

  3. Adam Smith and the Teaching of English Literature.

    ERIC Educational Resources Information Center

    Court, Franklin E.

    1985-01-01

    Adam Smith used selections from English literature in his classroom during the eighteenth century because he believed that vernacular literature could provide a ready context for the teaching of ideological, social, and moral lessons. He believed that higher education should prepare students for the real business of the real world. (RM)

  4. An Informal Report on Collegiate Successes with "The Adams Chronicles."

    ERIC Educational Resources Information Center

    Goldsberry, Gary G.

    In the spring of 1976, "The Adams Chronicles", a bicentennial television course developed by Coast Community College District and the University of California at San Diego, was distributed to colleges nationwide at no charge with the understanding that each college would return information regarding promotion, enrollment, and form of…

  5. Symposium 9: Rocky Mountain futures: preserving, utilizing, and sustaining Rocky Mountain ecosystems

    USGS Publications Warehouse

    Baron, Jill S.; Seastedt, Timothy; Fagre, Daniel B.; Hicke, Jeffrey A.; Tomback, Diana; Garcia, Elizabeth; Bowen, Zachary H.; Logan, Jesse A.

    2013-01-01

    In 2002 we published Rocky Mountain Futures, an Ecological Perspective (Island Press) to examine the cumulative ecological effects of human activity in the Rocky Mountains. We concluded that multiple local activities concerning land use, hydrologic manipulation, and resource extraction have altered ecosystems, although there were examples where the “tyranny of small decisions” worked in a positive way toward more sustainable coupled human/environment interactions. Superimposed on local change was climate change, atmospheric deposition of nitrogen and other pollutants, regional population growth, and some national management policies such as fire suppression.

  6. Secretion-Positive LGI1 Mutations Linked to Lateral Temporal Epilepsy Impair Binding to ADAM22 and ADAM23 Receptors

    PubMed Central

    Dazzo, Emanuela; Belluzzi, Elisa; Malacrida, Sandro; Vitiello, Libero; Greggio, Elisa; Tosatto, Silvio C. E.

    2016-01-01

    Autosomal dominant lateral temporal epilepsy (ADTLE) is a focal epilepsy syndrome caused by mutations in the LGI1 gene, which encodes a secreted protein. Most ADLTE-causing mutations inhibit LGI1 protein secretion, and only a few secretion-positive missense mutations have been reported. Here we describe the effects of four disease-causing nonsynonymous LGI1 mutations, T380A, R407C, S473L, and R474Q, on protein secretion and extracellular interactions. Expression of LGI1 mutant proteins in cultured cells shows that these mutations do not inhibit protein secretion. This finding likely results from the lack of effects of these mutations on LGI1 protein folding, as suggested by 3D protein modelling. In addition, immunofluorescence and co-immunoprecipitation experiments reveal that all four mutations significantly impair interaction of LGI1 with the ADAM22 and ADAM23 receptors on the cell surface. These results support the existence of a second mechanism, alternative to inhibition of protein secretion, by which ADLTE-causing LGI1 mutations exert their loss-of-function effect extracellularly, and suggest that interactions of LGI1 with both ADAM22 and ADAM23 play an important role in the molecular mechanisms leading to ADLTE. PMID:27760137

  7. Metalloproteinase inhibitors for the disintegrin-like metalloproteinases ADAM10 and ADAM17 that differentially block constitutive and phorbol ester-inducible shedding of cell surface molecules.

    PubMed

    Ludwig, Andreas; Hundhausen, Christian; Lambert, Millard H; Broadway, Neil; Andrews, Robert C; Bickett, D Mark; Leesnitzer, M Anthony; Becherer, J David

    2005-03-01

    The transmembrane metzinkin-proteases of the ADAM (a disintegrin and a metalloproteinase)-family ADAM10 and ADAM 17 are both implicated in the ectodomain shedding of various cell surface molecules including the IL6-receptor and the transmembrane chemokines CX3CL1 and CXCL16. These molecules are constitutively released from cultured cells, a process that can be rapidly enhanced by cell stimulation with phorbol esters such as PMA. Recent research supports the view that the constitutive cleavage predominantly involves ADAM10 while the inducible one is mediated to a large extent by ADAM17. We here describe the discovery of hydroxamate compounds with different potency against ADAM10 and ADAM17 and different ability to block constitutive and inducible cleavage of IL6R, CX3CL1 and CXCL16 by the two proteases. By screening a number of hydroxamate inhibitors for the inhibition of recombinant metalloproteinases, a compound was found inhibiting ADAM10 with more than 100-fold higher potency than ADAM17, which may be explained by an improved fit of the compound to the S1' specificity pocket of ADAM10 as compared to that of ADAM17. In cell-based cleavage experiments this compound (GI254023X) potently blocked the constitutive release of IL6R, CX3CL1 and CXCL16, which was in line with the reported involvement of ADAM10 but not ADAM17 in this process. By contrast, the compound did not affect the PMA-induced shedding, which was only blocked by GW280264X, a potent inhibitor of ADAM17. As expected, GI254023X did not further decrease the residual release of CX3CL1 and CXCL16 in ADAM10-deficient cells verifying that the compound's effect on the constitutive shedding of these molecules was exclusively due to the inhibition of ADAM10. Thus, GI254023X may by of use as a preferential inhibitor of constitutive shedding events without effecting the inducible shedding in response to agonists acting similar to PMA.

  8. ADAM17 silencing in mouse colon carcinoma cells: the effect on tumoricidal cytokines and angiogenesis.

    PubMed

    Das, Sudipta; Czarnek, Maria; Bzowska, Monika; Mężyk-Kopeć, Renata; Stalińska, Krystyna; Wyroba, Barbara; Sroka, Jolanta; Jucha, Jarosław; Deneka, Dawid; Stokłosa, Paulina; Ogonek, Justyna; Swartz, Melody A; Madeja, Zbigniew; Bereta, Joanna

    2012-01-01

    ADAM17 (a disintegrin and metalloprotease 17) is a major sheddase for numerous growth factors, cytokines, receptors, and cell adhesion molecules and is often overexpressed in malignant cells. It is generally accepted that ADAM17 promotes tumor development via activating growth factors from the EGF family, thus facilitating autocrine stimulation of tumor cell proliferation and migration. Here we show, using MC38CEA murine colon carcinoma model, that ADAM17 also regulates tumor angiogenesis and cytokine profile. When ADAM17 was silenced in MC38CEA cells, in vivo tumor growth and in vitro cell motility were significantly diminished, but no effect was seen on in vitro cell proliferation. ADAM17-silencing was accompanied by decreased in vitro expression of vascular endothelial growth factor-A and matrix metalloprotease-9, which was consistent with the limited angiogenesis and slower growth seen in ADAM17-silenced tumors. Among the growth factors susceptible to shedding by ADAM17, neuregulin-1 was the only candidate to mediate the effects of ADAM17 on MC38CEA motility and tumor angiogenesis. Concentrations of TNF and IFNγ, cytokines that synergistically induced proapoptotic effects on MC38CEA cells, were significantly elevated in the lysates of ADAM17-silenced tumors compared to mock transfected controls, suggesting a possible role for ADAM17 in host immune suppression. These results introduce new, complex roles of ADAM17 in tumor progression, including its impact on the anti-tumor immune response.

  9. A disintegrin and metalloprotease 10 (ADAM10) is a central regulator of murine liver tissue homeostasis

    PubMed Central

    Köhn-Gaone, Julia; Chalupsky, Karel; Lüllmann-Rauch, Renate; Barikbin, Roja; Bergmann, Juri; Wöhner, Birte; Zbodakova, Olga; Leuschner, Ivo; Martin, Gregor; Tiegs, Gisa; Rose-John, Stefan; Sedlacek, Radislav; Tirnitz-Parker, Janina E.E.; Saftig, Paul; Schmidt-Arras, Dirk

    2016-01-01

    A Disintegrin And Metalloprotease (ADAM) 10 exerts essential roles during organ development and tissue integrity in different organs, mainly through activation of the Notch pathway. However, only little is known about its implication in liver tissue physiology. Here we show that in contrast to its role in other tissues, ADAM10 is dispensable for the Notch2-dependent biliary tree formation. However, we demonstrate that expression of bile acid transporters is dependent on ADAM10. Consequently, mice deficient for Adam10 in hepatocytes, cholangiocytes and liver progenitor cells develop spontaneous hepatocyte necrosis and concomitant liver fibrosis. We furthermore observed a strongly augmented ductular reaction in 15-week old ADAM10Δhep/Δch mice and demonstrate that c-Met dependent liver progenitor cell activation is enhanced. Additionally, liver progenitor cells are primed to hepatocyte differentiation in the absence of ADAM10. These findings show that ADAM10 is a novel central node controlling liver tissue homeostasis. Highlights: Loss of ADAM10 in murine liver results in hepatocyte necrosis and concomitant liver fibrosis. ADAM10 directly regulates expression of bile acid transporters but is dispensable for Notch2-dependent formation of the biliary system. Activation of liver progenitor cells is enhanced through increased c-Met signalling, in the absence of ADAM10. Differentiation of liver progenitor cells to hepatocytes is augmented in the absence of ADAM10. PMID:26942887

  10. Transgenic overexpression of ADAM12 suppresses muscle regeneration and aggravates dystrophy in aged mdx mice.

    PubMed

    Jørgensen, Louise Helskov; Jensen, Charlotte Harken; Wewer, Ulla M; Schrøder, Henrik Daa

    2007-11-01

    Muscular dystrophies are characterized by insufficient restoration and gradual replacement of the skeletal muscle by fat and connective tissue. ADAM12 has previously been shown to alleviate the pathology of young dystrophin-deficient mdx mice, a model for Duchenne muscular dystrophy. The observed effect of ADAM12 was suggested to be mediated via a membrane-stabilizing up-regulation of utrophin, alpha7B integrin, and dystroglycans. Ectopic ADAM12 expression in normal mouse skeletal muscle also improved regeneration after freeze injury, presumably by the same mechanism. Hence, it was suggested that ADAM12 could be a candidate for nonreplacement gene therapy of Duchenne muscular dystrophy. We therefore evaluated the long-term effect of ADAM12 overexpression in muscle. Surprisingly, we observed loss of skeletal muscle and accelerated fibrosis and adipogenesis in 1-year-old mdx mice transgenically overexpressing ADAM12 (ADAM12(+)/mdx mice), even though their utrophin levels were mildly elevated compared with age-matched controls. Thus, membrane stabilization was not sufficient to provide protection during prolonged disease. Consequently, we reinvestigated skeletal muscle regeneration in ADAM12 transgenic mice (ADAM12(+)) after a knife cut lesion and observed that the regeneration process was significantly impaired. ADAM12 seemed to inhibit the satellite cell response and delay myoblast differentiation. These results discourage long-term therapeutic use of ADAM12. They also point to impaired regeneration as a possible factor in development of muscular dystrophy.

  11. Cell-surface metalloprotease ADAM12 is internalized by a clathrin- and Grb2-dependent mechanism.

    PubMed

    Stautz, Dorte; Leyme, Anthony; Grandal, Michael Vibo; Albrechtsen, Reidar; van Deurs, Bo; Wewer, Ulla; Kveiborg, Marie

    2012-11-01

    ADAM12 (A Disintegrin And Metalloprotease 12), a member of the ADAMs family of transmembrane proteins, is involved in ectodomain shedding, cell-adhesion and signaling, with important implications in cancer. Therefore, mechanisms that regulate the levels and activity of ADAM12 at the cell-surface are possibly crucial in these contexts. We here investigated internalization and subsequent recycling or degradation of ADAM12 as a potentially important regulatory mechanism. Our results show that ADAM12 is constitutively internalized primarily via the clathrin-dependent pathway and is subsequently detected in both early and recycling endosomes. The protease activity of ADAM12 does not influence this internalization mechanism. Analysis of essential elements for internalization established that proline-rich regions in the cytoplasmic domain of ADAM12, previously shown to interact with Src-homology 3 domains, were necessary for proper internalization. These sites in the ADAM12 cytoplasmic domain interacted with the adaptor protein growth factor receptor-bound protein 2 (Grb2) and knockdown of Grb2 markedly reduced ADAM12 internalization. These studies establish that internalization is indeed a mechanism that regulates ADAM cell surface levels and show that ADAM12 internalization involves the clathrin-dependent pathway and Grb2.

  12. Tetraspanin15 regulates cellular trafficking and activity of the ectodomain sheddase ADAM10.

    PubMed

    Prox, Johannes; Willenbrock, Michael; Weber, Silvio; Lehmann, Tobias; Schmidt-Arras, Dirk; Schwanbeck, Ralf; Saftig, Paul; Schwake, Michael

    2012-09-01

    A disintegrin and metalloproteinase10 (ADAM10) has been implicated as a major sheddase responsible for the ectodomain shedding of a number of important surface molecules including the amyloid precursor protein and cadherins. Despite a well-documented role of ADAM10 in health and disease, little is known about the regulation of this protease. To address this issue we conducted a split-ubiquitin yeast two-hybrid screen to identify membrane proteins that interact with ADAM10. The yeast experiments and co-immunoprecipitation studies in mammalian cell lines revealed tetraspanin15 (TSPAN15) to specifically associate with ADAM10. Overexpression of TSPAN15 or RNAi-mediated knockdown of TSPAN15 led to significant changes in the maturation process and surface expression of ADAM10. Expression of an endoplasmic reticulum (ER) retention mutant of TSPAN15 demonstrated an interaction with ADAM10 already in the ER. Pulse-chase experiments confirmed that TSPAN15 accelerates the ER-exit of the ADAM10-TSPAN15 complex and stabilizes the active form of ADAM10 at the cell surface. Importantly, TSPAN15 also showed the ability to mediate the regulation of ADAM10 protease activity exemplified by an increased shedding of N-cadherin and the amyloid precursor protein. In conclusion, our data show that TSPAN15 is a central modulator of ADAM10-mediated ectodomain shedding. Therapeutic manipulation of its expression levels may be an additional approach to specifically regulate the activity of the amyloid precursor protein alpha-secretase ADAM10.

  13. ADAM17 Silencing in Mouse Colon Carcinoma Cells: The Effect on Tumoricidal Cytokines and Angiogenesis

    PubMed Central

    Das, Sudipta; Czarnek, Maria; Bzowska, Monika; Mężyk-Kopeć, Renata; Stalińska, Krystyna; Wyroba, Barbara; Sroka, Jolanta; Jucha, Jarosław; Deneka, Dawid; Stokłosa, Paulina; Ogonek, Justyna; Swartz, Melody A.; Madeja, Zbigniew; Bereta, Joanna

    2012-01-01

    ADAM17 (a disintegrin and metalloprotease 17) is a major sheddase for numerous growth factors, cytokines, receptors, and cell adhesion molecules and is often overexpressed in malignant cells. It is generally accepted that ADAM17 promotes tumor development via activating growth factors from the EGF family, thus facilitating autocrine stimulation of tumor cell proliferation and migration. Here we show, using MC38CEA murine colon carcinoma model, that ADAM17 also regulates tumor angiogenesis and cytokine profile. When ADAM17 was silenced in MC38CEA cells, in vivo tumor growth and in vitro cell motility were significantly diminished, but no effect was seen on in vitro cell proliferation. ADAM17-silencing was accompanied by decreased in vitro expression of vascular endothelial growth factor-A and matrix metalloprotease-9, which was consistent with the limited angiogenesis and slower growth seen in ADAM17-silenced tumors. Among the growth factors susceptible to shedding by ADAM17, neuregulin-1 was the only candidate to mediate the effects of ADAM17 on MC38CEA motility and tumor angiogenesis. Concentrations of TNF and IFNγ, cytokines that synergistically induced proapoptotic effects on MC38CEA cells, were significantly elevated in the lysates of ADAM17-silenced tumors compared to mock transfected controls, suggesting a possible role for ADAM17 in host immune suppression. These results introduce new, complex roles of ADAM17 in tumor progression, including its impact on the anti-tumor immune response. PMID:23251384

  14. 76 FR 9350 - Patient Safety Organizations: Voluntary Delisting From Rocky Mountain Patient Safety Organization

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-17

    ... Delisting From Rocky Mountain Patient Safety Organization AGENCY: Agency for Healthcare Research and Quality (AHRQ), HHS. ACTION: Notice of Delisting. SUMMARY: Rocky Mountain Patient Safety Organization: AHRQ has accepted a notification of voluntary relinquishment from Rocky Mountain Patient Safety Organization,...

  15. Modeling rocky coastline evolution and equilibrium

    NASA Astrophysics Data System (ADS)

    Limber, P. W.; Murray, A. B.

    2010-12-01

    Many of the world’s rocky coastlines exhibit planform roughness in the form of alternating headlands and embayments. Along cliffed coasts, it is often assumed that headlands consist of rock that is more resistant to wave attack than in neighboring bays, because of either structural or lithologic variations. Bays would then retreat landward faster than headlands, creating the undulating planform profiles characteristic of a rocky coastal landscape. While the interplay between alongshore rock strength and nearshore wave energy is, in some circumstances, a fundamental control on coastline shape, beach sediment is also important. Laboratory experiments and field observations have shown that beach sediment, in small volumes, can act as an abrasive tool to encourage sea cliff retreat. In large volumes, though, sediment discourages wave attack on the cliff face, acting as a protective barrier. This nonlinearity suggests a means for headland persistence, even without alongshore variations in rock strength: bare-rock headlands could retreat more slowly than, or at the same rate as, neighboring sediment-filled embayments because of alongshore variations in the availability of beach sediment. Accordingly, nearshore sediment dynamics (i.e. sediment production from sea cliff retreat and alongshore sediment transport) could promote the development of autogenic planform geometry. To explore these ideas, we present numerical and analytical modeling of large-scale (> one kilometer) and long-term (millennial-scale) planform rocky coastline evolution, in which sediment is supplied by both sea cliff erosion and coastal rivers and is distributed by alongshore sediment transport. We also compare model predictions with real landscapes. Previously, our modeling exercises focused on a basic rocky coastline configuration where lithologically-homogeneous sea cliffs supplied all beach sediment and maintained a constant alongshore height. Results showed that 1) an equilibrium alongshore

  16. ADAM12 produced by tumor cells rather than stromal cells accelerates breast tumor progression.

    PubMed

    Fröhlich, Camilla; Nehammer, Camilla; Albrechtsen, Reidar; Kronqvist, Pauliina; Kveiborg, Marie; Sehara-Fujisawa, Atsuko; Mercurio, Arthur M; Wewer, Ulla M

    2011-11-01

    Expression of ADAM12 is low in most normal tissues but is markedly increased in numerous human cancers, including breast carcinomas. We have previously shown that overexpression of ADAM12 accelerates tumor progression in a mouse model of breast cancer (PyMT). In this study, we found that ADAM12 deficiency reduces breast tumor progression in the PyMT model. However, the catalytic activity of ADAM12 seems to be dispensable for its tumor-promoting effect. Interestingly, we show that ADAM12 endogenously expressed in tumor-associated stroma in the PyMT model does not influence tumor progression, but that ADAM12 expression by tumor cells is necessary for tumor progression in these mice. This finding is consistent with our observation that in human breast carcinoma, ADAM12 is almost exclusively located in tumor cells and, only rarely, seen in the tumor-associated stroma. We hypothesized, however, that the tumor-associated stroma may stimulate ADAM12 expression in tumor cells, on the basis of the fact that TGF-β1 stimulates ADAM12 expression and is a well-known growth factor released from tumor-associated stroma. TGF-β1 stimulation of ADAM12-negative Lewis lung tumor cells induced ADAM12 synthesis, and growth of these cells in vivo induced more than 200-fold increase in ADAM12 expression. Our observation that ADAM12 expression is significantly higher in the terminal duct lobular units (TDLU) adjacent to human breast carcinoma compared with TDLUs found in normal breast tissue supports our hypothesis that tumor-associated stroma triggers ADAM12 expression.

  17. Adams-Based Rover Terramechanics and Mobility Simulator - ARTEMIS

    NASA Technical Reports Server (NTRS)

    Trease, Brian P.; Lindeman, Randel A.; Arvidson, Raymond E.; Bennett, Keith; VanDyke, Lauren P.; Zhou, Feng; Iagnemma, Karl; Senatore, Carmine

    2013-01-01

    The Mars Exploration Rovers (MERs), Spirit and Opportunity, far exceeded their original drive distance expectations and have traveled, at the time of this reporting, a combined 29 kilometers across the surface of Mars. The Rover Sequencing and Visualization Program (RSVP), the current program used to plan drives for MERs, is only a kinematic simulator of rover movement. Therefore, rover response to various terrains and soil types cannot be modeled. Although sandbox experiments attempt to model rover-terrain interaction, these experiments are time-intensive and costly, and they cannot be used within the tactical timeline of rover driving. Imaging techniques and hazard avoidance features on MER help to prevent the rover from traveling over dangerous terrains, but mobility issues have shown that these methods are not always sufficient. ARTEMIS, a dynamic modeling tool for MER, allows planned drives to be simulated before commands are sent to the rover. The deformable soils component of this model allows rover-terrain interactions to be simulated to determine if a particular drive path would take the rover over terrain that would induce hazardous levels of slip or sink. When used in the rover drive planning process, dynamic modeling reduces the likelihood of future mobility issues because high-risk areas could be identified before drive commands are sent to the rover, and drives planned over these areas could be rerouted. The ARTEMIS software consists of several components. These include a preprocessor, Digital Elevation Models (DEMs), Adams rover model, wheel and soil parameter files, MSC Adams GUI (commercial), MSC Adams dynamics solver (commercial), terramechanics subroutines (FORTRAN), a contact detection engine, a soil modification engine, and output DEMs of deformed soil. The preprocessor is used to define the terrain (from a DEM) and define the soil parameters for the terrain file. The Adams rover model is placed in this terrain. Wheel and soil parameter files

  18. What's new in Rocky Mountain spotted fever?

    PubMed

    Chen, Luke F; Sexton, Daniel J

    2008-09-01

    Rocky Mountain spotted fever (RMSF) remains an important illness despite an effective therapy because it is difficult to diagnose and is capable of producing a fatal outcome. The pathogenesis of RMSF remains, in large part, an enigma. However, recent research has helped shed light on this mystery. Importantly, the diagnosis of RMSF must be considered in all febrile patients who have known or possible exposure to ticks, especially if they live in or have traveled to endemic regions during warmer months. Decisions about giving empiric therapy to such patients are difficult and require skill and careful judgement.

  19. Pumped storage job is a rocky challenge

    SciTech Connect

    Setzer, S.W.

    1994-03-07

    Georgia mountain lives up to its rugged name as excavators fight some unexpected ground conditions. When settlers pushed into the remote valleys of far northwestern Georgia, they had no idea just how apt the name given one odd geologic formation would become to a new generation of pioneers. Rocky Mountain`s 700 ft of diagonally upthrusting limestone, shale and sandstone layers have become the main antagonists in a decade-long struggle to place an 848-Mw pumped storage power project in and around the mountain.

  20. 36 CFR 7.7 - Rocky Mountain National Park.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Rocky Mountain National Park. 7.7 Section 7.7 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.7 Rocky Mountain National Park....

  1. 36 CFR 7.7 - Rocky Mountain National Park.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Rocky Mountain National Park. 7.7 Section 7.7 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.7 Rocky Mountain National Park....

  2. 36 CFR 7.7 - Rocky Mountain National Park.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Rocky Mountain National Park. 7.7 Section 7.7 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.7 Rocky Mountain National Park....

  3. 36 CFR 7.7 - Rocky Mountain National Park.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Rocky Mountain National Park. 7.7 Section 7.7 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.7 Rocky Mountain National Park....

  4. 36 CFR 7.7 - Rocky Mountain National Park.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Rocky Mountain National Park. 7.7 Section 7.7 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.7 Rocky Mountain National Park....

  5. 30. NORTHERN SEGMENT OF THE LATERAL IN THE NORTHWEST QUARTER ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    30. NORTHERN SEGMENT OF THE LATERAL IN THE NORTHWEST QUARTER OF SECTION 25 STRUCTURE PICTURED IN CO-43-A-28. - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  6. 28. CONCRETE DIVERSION STRUCTURE ON THE WEST SIDE OF D ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    28. CONCRETE DIVERSION STRUCTURE ON THE WEST SIDE OF D STREET ABOUT ONE-QUARTER MILE SOUTH OF 9TH AVNEUE (SECTION 26); THE LATERAL CONTINUES NORTHEAST WHILE A SIDE DITCH PROCEEDS NORTHWARD. THE DIVERSION STRUCTURE SHOWN IN CO-43-A-27 IS VISIBLE IN THE DISTANCE. - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  7. 10. CONCRETE DIVERSION CHANNEL EXTENDING TOWARD LAKE LADORA FROM THE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. CONCRETE DIVERSION CHANNEL EXTENDING TOWARD LAKE LADORA FROM THE DIVERSION STRUCTURE WEST OF LOWER DERBY LAKE (SECTION 2). - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  8. 12. CONCRETE LINING ON A CURVING SEGMENT OF THE LATERAL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. CONCRETE LINING ON A CURVING SEGMENT OF THE LATERAL NEAR THE NORTHEAST END OF LAKE LADORA (SECTION 2). - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  9. 15. CONCRETE CHECK DAM NORTHWEST OF SOUTHEAST LAKE LADORA (SECTION ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    15. CONCRETE CHECK DAM NORTHWEST OF SOUTHEAST LAKE LADORA (SECTION 2) WITH THE FORMER EGLI FARM IN THE DISTANCE. - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  10. 27. DIVERSION STRUCTURE WITH CONCRETE SIDEWALLS AND CONCRETE CHANNEL BEYOND, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    27. DIVERSION STRUCTURE WITH CONCRETE SIDEWALLS AND CONCRETE CHANNEL BEYOND, A SHORT DISTANCE WEST OF D STREET ABOUT ONE-QUARTER MILE SOUTH OF 9TH AVENUE (SECTION 26). - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  11. 1. HEAD GATE OF THE SAND CREEK LATERAL AT THE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. HEAD GATE OF THE SAND CREEK LATERAL AT THE HIGH LINE CANAL ON THE SOUTH END OF THE PEORIA STREET BRIDGE. - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  12. 19. OUTLET OF PIPE WITH A CONCRETE CHANNEL SERVING THE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    19. OUTLET OF PIPE WITH A CONCRETE CHANNEL SERVING THE HEAD GATE SHOWN IN CO-43-A-18. - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  13. 11. CONTINUATION OF LATERAL LEAVING THE DIVERSION STRUCTURE WEST OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. CONTINUATION OF LATERAL LEAVING THE DIVERSION STRUCTURE WEST OF LOWER DERBY LAKE (SECTION 2), SHOWING MEASURING GAUGE. - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  14. 29. VIEW OF THE DIVERSION STRUCTURE PICTURED IN CO43A28 FROM ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    29. VIEW OF THE DIVERSION STRUCTURE PICTURED IN CO-43-A-28 FROM THE CHANNEL OF THE LATERAL, SHOWING THE UPSTREAM FACE OF THE STRUCTURE. - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  15. 18. DETAIL OF HEAD GATE ABOUT 1,100 FEET NORTH OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    18. DETAIL OF HEAD GATE ABOUT 1,100 FEET NORTH OF 7TH AVENUE (SECTION 35), SHOWING CHANNEL IN WIHCH GATE WAS RAISED AND LOWERED. - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  16. System Verification of MSL Skycrane Using an Integrated ADAMS Simulation

    NASA Technical Reports Server (NTRS)

    White, Christopher; Antoun, George; Brugarolas, Paul; Lih, Shyh-Shiuh; Peng, Chia-Yen; Phan, Linh; San Martin, Alejandro; Sell, Steven

    2012-01-01

    Mars Science Laboratory (MSL) will use the Skycrane architecture to execute final descent and landing maneuvers. The Skycrane phase uses closed-loop feedback control throughout the entire phase, starting with rover separation, through mobility deploy, and through touchdown, ending only when the bridles have completely slacked. The integrated ADAMS simulation described in this paper couples complex dynamical models created by the mechanical subsystem with actual GNC flight software algorithms that have been compiled and linked into ADAMS. These integrated simulations provide the project with the best means to verify key Skycrane requirements which have a tightly coupled GNC-Mechanical aspect to them. It also provides the best opportunity to validate the design of the algorithm that determines when to cut the bridles. The results of the simulations show the excellent performance of the Skycrane system.

  17. ADAM: An Axisymmetric Duct Aeroacoustic Modeling system. [aircraft turbofan engines

    NASA Technical Reports Server (NTRS)

    Abrahamson, A. L.

    1983-01-01

    An interconnected system of computer programs for analyzing the propagation and attenuation of sound in aeroengine ducts containing realistic compressible subsonic mean flows, ADAM was developed primarily for research directed towards the reduction of noise emitted from turbofan aircraft engines. The two basic components are a streamtube curvature program for determination of the mean flow, and a finite element code for solution of the acoustic propagation problem. The system, which has been specifically tailored for ease of use, is presently installed at NASA Langley Reseach Center on a Control Data Cyber 175 Computer under the NOS Operating system employing a Tektronix terminal for interactive graphics. The scope and organization of the ADAM system is described. A users guide, examples of input data, and results for selected cases are included.

  18. Empathy's purity, sympathy's complexities; De Waal, Darwin and Adam Smith.

    PubMed

    van der Weele, Cor

    2011-07-01

    Frans de Waal's view that empathy is at the basis of morality directly seems to build on Darwin, who considered sympathy as the crucial instinct. Yet when we look closer, their understanding of the central social instinct differs considerably. De Waal sees our deeply ingrained tendency to sympathize (or rather: empathize) with others as the good side of our morally dualistic nature. For Darwin, sympathizing was not the whole story of the "workings of sympathy"; the (selfish) need to receive sympathy played just as central a role in the complex roads from sympathy to morality. Darwin's understanding of sympathy stems from Adam Smith, who argued that the presence of morally impure motives should not be a reason for cynicism about morality. I suggest that De Waal's approach could benefit from a more thorough alignment with the analysis of the workings of sympathy in the work of Darwin and Adam Smith.

  19. Automatic Dynamic Aircraft Modeler (ADAM) for the Computer Program NASTRAN

    NASA Technical Reports Server (NTRS)

    Griffis, H.

    1985-01-01

    Large general purpose finite element programs require users to develop large quantities of input data. General purpose pre-processors are used to decrease the effort required to develop structural models. Further reduction of effort can be achieved by specific application pre-processors. Automatic Dynamic Aircraft Modeler (ADAM) is one such application specific pre-processor. General purpose pre-processors use points, lines and surfaces to describe geometric shapes. Specifying that ADAM is used only for aircraft structures allows generic structural sections, wing boxes and bodies, to be pre-defined. Hence with only gross dimensions, thicknesses, material properties and pre-defined boundary conditions a complete model of an aircraft can be created.

  20. Distal Limb Defects and Aplasia Cutis: Adams-Oliver Syndrome.

    PubMed

    Renfree, Kevin J; Dell, Paul C

    2016-07-01

    Adams-Oliver syndrome is a rare congenital condition that should be considered in persons with terminal transverse limb deficiencies and scalp defects (aplasia cutis congenita). Broad phenotypic variability exists in this condition. In its more severe forms, Adams-Oliver syndrome can involve the cardiovascular system, central nervous system, gastrointestinal tract, and genitourinary system and should require prompt evaluation by appropriate subspecialists. Extremity involvement is typically bilateral and asymmetrical, with lower extremities involved more than upper extremities. Brachydactyly is the most common limb defect, and severity ranges from hypoplastic nails to complete absence of the distal limb. The syndrome has been described as resulting from autosomal dominant and recessive modes of inheritance, but most cases are sporadic. No gene has been identified. Although the exact pathogenic mechanism is unknown, a common hypothesis is that a vascular disturbance occurs in watershed areas, such as cranial vertex and limbs, during fetal development.

  1. Application of the ADAMS program to deployable space truss structures

    NASA Technical Reports Server (NTRS)

    Calleson, R. E.

    1985-01-01

    The need for a computer program to perform kinematic and dynamic analyses of large truss structures while deploying from a packaged configuration in space led to the evaluation of several existing programs. ADAMS (automatic dynamic analysis of mechanical systems), a generalized program from performing the dynamic simulation of mechanical systems undergoing large displacements, is applied to two concepts of deployable space antenna units. One concept is a one cube folding unit of Martin Marietta's Box Truss Antenna and the other is a tetrahedral truss unit of a Tetrahedral Truss Antenna. Adequate evaluation of dynamic forces during member latch-up into the deployed configuration is not yet available from the present version of ADAMS since it is limited to the assembly of rigid bodies. Included is a method for estimating the maximum bending stress in a surface member at latch-up. Results include member displacement and velocity responses during extension and an example of member bending stresses at latch-up.

  2. Risk, media, and stigma at Rocky Flats

    SciTech Connect

    Flynn, J.; Peters, E.; Mertz, C.K.; Slovic, P.

    1998-12-01

    Public responses to nuclear technologies are often strongly negative. Events, such as accidents or evidence of unsafe conditions at nuclear facilities, receive extensive and dramatic coverage by the news media. These news stories affect public perceptions of nuclear risks and the geographic areas near nuclear facilities. One result of these perceptions, avoidance behavior, is a form of technological stigma that leads to losses in property values near nuclear facilities. The social amplification of risk is a conceptual framework that attempts to explain how stigma is created through media transmission of information about hazardous places and public perceptions and decisions. This paper examines stigma associated with the US Department of energy`s Rocky Flats facility, a major production plant in the nation`s nuclear weapons complex, located near Denver, Colorado. This study, based upon newspaper analyses and a survey of Denver area residents, finds that the social amplification theory provides a reasonable framework for understanding the events and public responses that took place in regard to Rocky Flats during a 6-year period, beginning with an FBI raid of the facility in 1989.

  3. Rocky River Watershed Based Curriculum Guide Project

    NASA Astrophysics Data System (ADS)

    Cox, Phillip Howard

    Environmental education has the ability to increase cognitive ability, have a positive impact on group work skills, attitudes and self-efficacy, and increase student performance. Due to Federal "No Child Left Behind Act" legislation, increased standardized testing has resulted in the disenfranchisement of students from formal learning. The purpose of this project was to develop a curriculum guide based on the Rocky River watershed so teachers could use the Rocky River watershed as a means to satisfy the objectives of the NC Standard Course of Study and at the same time increase student environmental awareness, classroom engagement, sense of place and scores on the NC Earth/Environmental Final Exams. The project was developed to correlate with the newly revised North Carolina Standard Course of Study for Earth/Environmental Science. The curriculum guide was developed by utilizing the best practices suggested by scientific literature, the NC Standard Course of Study for Earth/Environmental Science, the North American Association for Environmental Education and the National Education Association.

  4. Quantifying the Effects of Temperature on Rocky Planets

    NASA Astrophysics Data System (ADS)

    Berger, Sabrina; Rogers, Leslie

    2017-01-01

    Rocky planets can be very diverse in structure and composition compared to the Earth. Their temperature profiles could also differ greatly from Earth’s depending on their mass and distance from their host stars. Interior structure models of rocky exoplanets have not yet studied the full range of possible temperature profiles. We develop a simulation, PyPlanet, for a rocky planet with an arbitrary number of layers and equations of state. We apply this model to explore many possible temperature profiles and quantify the thermal effects on the mass-radius relations of rocky planets.This detailed modeling will be crucial for making robust inferences about rocky planet structure and composition from transit and radial velocity observations.

  5. Evaluation of ADAM/1 model for advanced coal extraction concepts

    NASA Technical Reports Server (NTRS)

    Deshpande, G. K.; Gangal, M. D.

    1982-01-01

    Several existing computer programs for estimating life cycle cost of mining systems were evaluated. A commercially available program, ADAM/1 was found to be satisfactory in relation to the needs of the advanced coal extraction project. Two test cases were run to confirm the ability of the program to handle nonconventional mining equipment and procedures. The results were satisfactory. The model, therefore, is recommended to the project team for evaluation of their conceptual designs.

  6. Control of ADAM17 activity by regulation of its cellular localisation

    PubMed Central

    Lorenzen, Inken; Lokau, Juliane; Korpys, Yvonne; Oldefest, Mirja; Flynn, Charlotte M.; Künzel, Ulrike; Garbers, Christoph; Freeman, Matthew; Grötzinger, Joachim; Düsterhöft, Stefan

    2016-01-01

    An important, irreversible step in many signalling pathways is the shedding of membrane-anchored proteins. A Disintegrin And Metalloproteinase (ADAM) 17 is one of the major sheddases involved in a variety of physiological and pathophysiological processes including regeneration, differentiation, and cancer progression. This central role in signalling implies that ADAM17 activity has to be tightly regulated, including at the level of localisation. Most mature ADAM17 is localised intracellularly, with only a small amount at the cell surface. We found that ADAM17 is constitutively internalised by clathrin-coated pits and that physiological stimulators such as GPCR ligands induce ADAM17-mediated shedding, but do not alter the cell-surface abundance of the protease. In contrast, the PKC-activating phorbol ester PMA, often used as a strong inducer of ADAM17, causes not only proteolysis by ADAM17 but also a rapid increase of the mature protease at the cell surface. This is followed by internalisation and subsequent degradation of the protease. Eventually, this leads to a substantial downregulation of mature ADAM17. Our results therefore imply that physiological activation of ADAM17 does not rely on its relocalisation, but that PMA-induced PKC activity drastically dysregulates the localisation of ADAM17. PMID:27731361

  7. Neuronal ADAM10 Promotes Outgrowth of Small-Caliber Myelinated Axons in the Peripheral Nervous System.

    PubMed

    Meyer zu Horste, Gerd; Derksen, Angelika; Stassart, Ruth; Szepanowski, Fabian; Thanos, Melissa; Stettner, Mark; Boettcher, Christina; Lehmann, Helmar C; Hartung, Hans-Peter; Kieseier, Bernd C

    2015-11-01

    The regulation of myelination and axonal outgrowth in the peripheral nervous system is controlled by a complex signaling network involving various signaling pathways. Members of the A Disintegrin And Metalloproteinase (ADAM) family are membrane-anchored proteinases with both proteolytic and disintegrin characteristics that modulate the function of signaling molecules. One family member, ADAM17, is known to influence myelination by cleaving and thus regulating one of the key signals, neuregulin-1, which controls peripheral nervous system myelination. A similar function for ADAM10 had been suggested by previous in vitro studies. Here, we assessed whether ADAM10 exerts a similar function in vivo and deleted ADAM10 in a cell type-specific manner in either neurons or Schwann cells. We found that ADAM10 is not required in either Schwann cells or neurons for normal myelination during development or for remyelination after injury. Instead, ADAM10 is required specifically in neurons for the outgrowth of myelinated small-fiber axons in vitro and after injury in vivo. Thus, we report for the first time a neuron-intrinsic function of ADAM10 in axonal regeneration that is distinct from that of the related protein family member ADAM17 and that may have implications for targeting ADAM function in nervous system diseases.

  8. Circulating ADAM17 Level Reflects Disease Activity in Proteinase-3 ANCA-Associated Vasculitis.

    PubMed

    Bertram, Anna; Lovric, Svjetlana; Engel, Alissa; Beese, Michaela; Wyss, Kristin; Hertel, Barbara; Park, Joon-Keun; Becker, Jan U; Kegel, Johanna; Haller, Hermann; Haubitz, Marion; Kirsch, Torsten

    2015-11-01

    ANCA-associated vasculitides are characterized by inflammatory destruction of small vessels accompanied by enhanced cleavage of membrane-bound proteins. One of the main proteases responsible for ectodomain shedding is disintegrin and metalloproteinase domain-containing protein 17 (ADAM17). Given its potential role in aggravating vascular dysfunction, we examined the role of ADAM17 in active proteinase-3 (PR3)-positive ANCA-associated vasculitis (AAV). ADAM17 concentration was significantly increased in plasma samples from patients with active PR3-AAV compared with samples from patients in remission or from other controls with renal nonvascular diseases. Comparably, plasma levels of the ADAM17 substrate syndecan-1 were significantly enhanced in active AAV. We also observed that plasma-derived ADAM17 retained its specific proteolytic activity and was partly located on extracellular microparticles. Transcript levels of ADAM17 were increased in blood samples of patients with active AAV, but those of ADAM10 or tissue inhibitor of metalloproteinases 3, which inhibits ADAMs, were not. We also performed a microRNA (miR) screen and identified miR-634 as significantly upregulated in blood samples from patients with active AAV. In vitro, miR-634 mimics induced a proinflammatory phenotype in monocyte-derived macrophages, with enhanced expression and release of ADAM17 and IL-6. These data suggest that ADAM17 has a prominent role in AAV and might account for the vascular complications associated with this disease.

  9. Involvement of ADAM10 in axonal outgrowth and myelination of the peripheral nerve.

    PubMed

    Jangouk, Parastoo; Dehmel, Thomas; Meyer Zu Hörste, Gerd; Ludwig, Andreas; Lehmann, Helmar C; Kieseier, Bernd C

    2009-12-01

    The disintegrin and metalloproteinase 10 (ADAM10) is a membrane-anchored metalloproteinase with both proteolytic and disintegrin characteristics. Here, we investigate the expression, regulation, and functional role of ADAM10 in axonal outgrowth and myelination of the peripheral nerve. Expression pattern analysis of 11 ADAM family members in co-cultures of rat dorsal root ganglia (DRG) neurons and Schwann cells (SCs) demonstrated the most pronounced mRNA expression for ADAM10. In further studies, ADAM10 was found to be consistently upregulated in DRG-SC co-cultures before the induction of myelination. Neurons as well as SCs widely expressed ADAM10 at the protein level. In neurons, the expression of ADAM10 was exclusively limited to the axons before the induction of myelination. Inhibition of ADAM10 activity by the hydroxamate-based inhibitors GI254023X and GW280264X resulted in a significant decrease in the mean axonal length. These data suggest that ADAM10 represents a prerequisite for myelination, although its activity is not required during the process of myelination itself as demonstrated by expression analysis of myelin protein zero (P0) and Sudan black staining. Hence, during the process of myelin formation, ADAM10 is highly upregulated and appears to be critically involved in axonal outgrowth that is a requirement for myelination in the peripheral nerve.

  10. Circulating ADAM17 Level Reflects Disease Activity in Proteinase-3 ANCA-Associated Vasculitis

    PubMed Central

    Bertram, Anna; Lovric, Svjetlana; Engel, Alissa; Beese, Michaela; Wyss, Kristin; Hertel, Barbara; Park, Joon-Keun; Becker, Jan U.; Kegel, Johanna; Haller, Hermann; Haubitz, Marion

    2015-01-01

    ANCA-associated vasculitides are characterized by inflammatory destruction of small vessels accompanied by enhanced cleavage of membrane-bound proteins. One of the main proteases responsible for ectodomain shedding is disintegrin and metalloproteinase domain-containing protein 17 (ADAM17). Given its potential role in aggravating vascular dysfunction, we examined the role of ADAM17 in active proteinase-3 (PR3)-positive ANCA-associated vasculitis (AAV). ADAM17 concentration was significantly increased in plasma samples from patients with active PR3-AAV compared with samples from patients in remission or from other controls with renal nonvascular diseases. Comparably, plasma levels of the ADAM17 substrate syndecan-1 were significantly enhanced in active AAV. We also observed that plasma-derived ADAM17 retained its specific proteolytic activity and was partly located on extracellular microparticles. Transcript levels of ADAM17 were increased in blood samples of patients with active AAV, but those of ADAM10 or tissue inhibitor of metalloproteinases 3, which inhibits ADAMs, were not. We also performed a microRNA (miR) screen and identified miR-634 as significantly upregulated in blood samples from patients with active AAV. In vitro, miR-634 mimics induced a proinflammatory phenotype in monocyte-derived macrophages, with enhanced expression and release of ADAM17 and IL-6. These data suggest that ADAM17 has a prominent role in AAV and might account for the vascular complications associated with this disease. PMID:25788529

  11. Upregulated expression of ADAM12 is associated with progression of oral squamous cell carcinoma.

    PubMed

    Uehara, Erika; Shiiba, Masashi; Shinozuka, Keiji; Saito, Kengo; Kouzu, Yukinao; Koike, Hirofumi; Kasamatsu, Atsushi; Sakamoto, Yosuke; Ogawara, Katsunori; Uzawa, Katsuhiro; Tanzawa, Hideki

    2012-05-01

    ADAMs are a disintegrin and metalloproteinase family of membrane-associated metalloproteinases characterized by their multidomain structure, and have been reported to be associated with various malignant tumors. The aim of this study was to identify crucial members of the ADAM family in oral squamous cell carcinoma (OSCC), and to reveal their biological function and clinical significance. To clarify whether ADAM family genes are involved in OSCC, changes in the expression profile were investigated by real-time quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) analysis and immunohistochemical analysis. Functional analysis was performed by comparing cellular proliferation of siADAM-transfected cell lines and parental cell lines. Real-time qRT-PCR analysis identified significantly upregulated expression of ADAM12 in OSCC-derived cell lines. This was validated in OSCC samples using real-time qRT-PCR and immuno-histochemical staining. ADAM12 expression was correlated with TNM classification; significantly greater expression of ADAM12 was observed in tumors with higher T classification and more advanced stages. Moreover, siADAM12-transfected cells showed both a suppressed proliferation rate and increased transforming growth factor (TGF)-β3 expression. Our data indicate that ADAM12 is overexpressed in OSCC and might accelerate cellular proliferation. Its function may be associated with TGF-β signaling. This study suggests that controlling the expression or activity of ADAM12 could be a useful strategy in the development of an effective cure for OSCC.

  12. Dr. Lytle Adams' incendiary "bat bomb" of World War II.

    PubMed

    Christen, Arden G; Christen, Joan A

    2004-11-01

    On December 7, 1941, a 60-year old dentist from Irwin, Pennsylvania, Dr. Lytle S. Adams, was driving home from a vacation at Carlsbad Caverns in New Mexico. Hours earlier, he had been gripped with amazement as he witnessed millions of bats exiting the caves of Carlsbad. Listening to his car radio on his return trip, he was shocked to hear that Japan had just attacked Pearl Harbor. Dr. Adams, outraged over this travesty, began to mentally construct a plan for U.S. retaliation. As his thoughts returned to the countless bats that had awed him, he formed a tentative plan: millions of these small, flying mammals could be connected to tiny, time-fused incendiary bombs, and then released to land on the flimsily constructed structures which dotted the cities of Japan. Within a few minutes, the bombs would explode and enflame the entire urban areas. He postulated that these immeasurable numbers of fires, spreading their devastation over such vast areas within Japanese cities would result in the enemy's speedy surrender. This article documents the futile efforts of Dr. Adams, his team and the U.S. government to develop and employ an effective, incendiary bat bomb. The recently developed atom bomb, a far more deadly weapon was used in its place.

  13. [The importance of ADAM family proteins in malignant tumors].

    PubMed

    Walkiewicz, Katarzyna; Gętek, Monika; Muc-Wierzgoń, Małgorzata; Kokot, Teresa; Nowakowska-Zajdel, Ewa

    2016-02-11

    Increasing numbers of reports about the role of adamalysins (ADAM) in malignant tumors are being published. To date, more than 30 representatives of this group, out of which about 20 occur in humans, have been described. The ADAM family is a homogeneous group of proteins which regulate, from the stage of embryogenesis, a series of processes such as cell migration, adhesion, and cell fusion. Half of them have proteolytic activity and are involved in the degradation of the extracellular matrix and the disintegration of certain protein complexes, thereby regulating the bioavailability of various growth factors. Many of these functions have a direct role in the processes of carcinogenesis and promoting the growth of tumor, which affect some signaling pathways, including those related to insulin-like growth factors (IGF1, IGF2), vascular growth factor (VEGF), tumor necrosis factor α (TNFα) and the EGFR/HER pathway. Another branch of studies is the evaluation of the possibility of using members of ADAM family proteins in the diagnosis, especially in breast, colon and non- small cell lung cancer. The detection of concentrations of adamalysin in serum, urine and pleural aspirates might contribute to the development of methods of early diagnosis of cancer and monitoring the therapy. However, both the role of adamalysins in the development and progression of tumors and their importance as a diagnostic and predictive further research still need to be checked on large groups of patients.

  14. ADAM8 Enhances Osteoclast Precursor Fusion and Osteoclast Formation In Vitro and In Vivo

    PubMed Central

    Ishizuka, Hisako; García-Palacios, Verónica; Lu, Ganwei; Subler, Mark A; Zhang, Heju; Boykin, Christina S; Choi, Sun Jin; Zhao, Liena; Patrene, Kenneth; Galson, Deborah L; Blair, Harry C; Hadi, Tamer M; Windle, Jolene J; Kurihara, Noriyoshi; Roodman, G David

    2011-01-01

    ADAM8 expression is increased in the interface tissue around a loosened hip prosthesis and in the pannus and synovium of patients with rheumatoid arthritis, but its potential role in these processes is unclear. ADAM8 stimulates osteoclast (OCL) formation, but the effects of overexpression or loss of expression of ADAM8 in vivo and the mechanisms responsible for the effects of ADAM8 on osteoclastogenesis are unknown. Therefore, to determine the effects of modulating ADAM expression, we generated tartrate-resistant acid phosphatase (TRAP)–ADAM8 transgenic mice that overexpress ADAM8 in the OCL lineage and ADAM8 knockout (ADAM8 KO) mice. TRAP-ADAM8 mice developed osteopenia and had increased numbers of OCL precursors that formed hypermultinucleated OCLs with an increased bone-resorbing capacity per OCL. They also had an enhanced differentiation capacity, increased TRAF6 expression, and increased NF-κB, Erk, and Akt signaling compared with wild-type (WT) littermates. This increased bone-resorbing capacity per OCL was associated with increased levels of p-Pyk2 and p-Src activation. In contrast, ADAM8 KO mice did not display a bone phenotype in vivo, but unlike WT littermates, they did not increase RANKL production, OCL formation, or calvarial fibrosis in response to tumor necrosis factor α (TNF-α) in vivo. Since loss of ADAM8 does not inhibit basal bone remodeling but only blocks the enhanced OCL formation in response to TNF-α, these results suggest that ADAM8 may be an attractive therapeutic target for preventing bone destruction associated with inflammatory disease. © 2011 American Society for Bone and Mineral Research. PMID:20683884

  15. iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling

    PubMed Central

    Li, Xue; Maretzky, Thorsten; Weskamp, Gisela; Monette, Sébastien; Qing, Xiaoping; Issuree, Priya Darshinee A.; Crawford, Howard C.; McIlwain, David R.; Mak, Tak W.; Salmon, Jane E.; Blobel, Carl P.

    2015-01-01

    The metalloproteinase ADAM17 (a disintegrin and metalloprotease 17) controls EGF receptor (EGFR) signaling by liberating EGFR ligands from their membrane anchor. Consequently, a patient lacking ADAM17 has skin and intestinal barrier defects that are likely caused by lack of EGFR signaling, and Adam17−/− mice die perinatally with open eyes, like Egfr−/− mice. A hallmark feature of ADAM17-dependent EGFR ligand shedding is that it can be rapidly and posttranslationally activated in a manner that requires its transmembrane domain but not its cytoplasmic domain. This suggests that ADAM17 is regulated by other integral membrane proteins, although much remains to be learned about the underlying mechanism. Recently, inactive Rhomboid 2 (iRhom2), which has seven transmembrane domains, emerged as a molecule that controls the maturation and function of ADAM17 in myeloid cells. However, iRhom2−/− mice appear normal, raising questions about how ADAM17 is regulated in other tissues. Here we report that iRhom1/2−/− double knockout mice resemble Adam17−/− and Egfr−/− mice in that they die perinatally with open eyes, misshapen heart valves, and growth plate defects. Mechanistically, we show lack of mature ADAM17 and strongly reduced EGFR phosphorylation in iRhom1/2−/− tissues. Finally, we demonstrate that iRhom1 is not essential for mouse development but regulates ADAM17 maturation in the brain, except in microglia, where ADAM17 is controlled by iRhom2. These results provide genetic, cell biological, and biochemical evidence that a principal function of iRhoms1/2 during mouse development is to regulate ADAM17-dependent EGFR signaling, suggesting that iRhoms1/2 could emerge as novel targets for treatment of ADAM17/EGFR-dependent pathologies. PMID:25918388

  16. The alpha secretase ADAM10: A metalloprotease with multiple functions in the brain.

    PubMed

    Saftig, Paul; Lichtenthaler, Stefan F

    2015-12-01

    Proteins belonging to the 'A Disintegrin And Metalloproteinase' (ADAM) family are membrane-anchored proteases that are able to cleave the extracellular domains of several membrane-bound proteins in a process known as 'ectodomain shedding'. In the central nervous system, ADAM10 has attracted the most attention, since it was described as the amyloid precursor protein α-secretase over ten years ago. Despite the excitement over the potential of ADAM10 as a novel drug target in Alzheimer disease, the physiological functions of ADAM10 in the brain are not yet well understood. This is largely because of the embryonic lethality of ADAM10-deficient mice, which results from the loss of cleavage and signaling of the Notch receptor, another ADAM10 substrate. However, the recent generation of conditional ADAM10-deficient mice and the identification of further ADAM10 substrates in the brain has revealed surprisingly numerous and fundamental functions of ADAM10 in the development of the embryonic brain and also in the homeostasis of adult neuronal networks. Mechanistically, ADAM10 controls these functions by utilizing unique postsynaptic substrates in the central nervous system, in particular synaptic cell adhesion molecules, such as neuroligin-1, N-cadherin, NCAM, Ephrin A2 and A5. Consequently, a dysregulation of ADAM10 activity is linked to psychiatric and neurological diseases, such as epilepsy, fragile X syndrome and Huntington disease. This review highlights the recent progress in understanding the substrates and function as well as the regulation and cell biology of ADAM10 in the central nervous system and discusses the value of ADAM10 as a drug target in brain diseases.

  17. Modulation of integrin α4β1 by ADAM28 promotes lymphocyte adhesion and transendothelial migration.

    PubMed

    McGinn, Owen J; English, William R; Roberts, Stephanie; Ager, Ann; Newham, Peter; Murphy, Gillian

    2011-10-01

    ADAMs (a disintegrin and metalloproteinase) are a family of type I transmembrane glycoproteins related to snake venom metalloproteases and disintegrins. They are regulatory proteins that modulate intercellular adhesion and the bioavailability of growth factors, and have been implicated in many disease states, including cancer, immunity and inflammation. One member of the ADAM family, ADAM28, has been reported to bind to the integrin α4β1 in humans; however, the distribution of ADAM28 and the biological consequences of ADAM28-α4β1 interactions are yet to be fully elucidated. The expression of ADAM28 in human and murine tissues was examined by multiple Affymetrix microarray analyses, real-time RT-PCR (reverse transcription-PCR) and immunohistochemical staining. We found that ADAM28 has a relatively restricted expression pattern in mouse and human and is highly expressed in the B-lymphocyte lineage, including chronic lymphocytic leukaemic B-cells. The murine B-lymphoma line L1-2 and recombinant soluble murine ADAM28 were used to investigate ADAM28-α4β1 interactions. Our data reveal that ADAM28 binding to α4β1 is typical of integrin-ligand interactions, since it is attenuated by anti-functional integrin antibodies, and is enhanced by Mn2+ and the integrin mAb (monoclonal antibody) 9EG7. However, a key finding was that soluble ADAM28 unexpectedly enhanced α4β1-dependent cell adhesion to VCAM-1 (vascular cell adhesion molecule-1). In so doing ADAM28 was able to influence lymphocyte adhesion to, and migration through, endothelial monolayers, suggesting a physiological role for ADAM28 in regulating the specific spatial and temporal transendothelial migration of lymphocytes.

  18. A Disintegrin and Metalloprotease (ADAM) 10 and ADAM17 Are Major Sheddases of T Cell Immunoglobulin and Mucin Domain 3 (Tim-3)*

    PubMed Central

    Möller-Hackbarth, Katja; Dewitz, Christin; Schweigert, Olga; Trad, Ahmad; Garbers, Christoph; Rose-John, Stefan; Scheller, Jürgen

    2013-01-01

    T cell immunoglobulin and mucin domain 3 (Tim-3) dampens the response of CD4+ and CD8+ effector T cells via induction of cell death and/or T cell exhaustion and enhances the ability of macrophages to clear pathogens via binding to galectin 9. Here we provide evidence that human Tim-3 is a target of A disintegrin and metalloprotease (ADAM)-mediated ectodomain shedding resulting in a soluble form of Tim-3. We identified ADAM10 and ADAM17 as major sheddases of Tim-3 as shown by ADAM-specific inhibitors and the ADAM10 pro-domain in HEK293 cells and ADAM10/ADAM17-deficient murine embryonic fibroblasts. PMA-induced shedding of Tim-3 was abrogated by deletion of amino acids Glu181–Asp190 of the stalk region and Tim-3 lacking the intracellular domain was not efficiently cleaved after PMA stimulation. Surprisingly, a single lysine residue within the intracellular domain rescues shedding of Tim-3. Shedding of endogenous Tim-3 was found in primary human CD14+ monocytes after PMA and ionomycin stimulation. Importantly, the recently described down-regulation of Tim-3 from Toll-like receptor-activated CD14+ monocytes was caused by ADAM10- and ADAM17-mediated shedding. Inhibition of Tim-3 shedding from lipopolysaccharide-induced monocytes did not influence lipopolysaccharide-induced TNFα and IL-6 but increases IL-12 expression. In summary, we describe Tim-3 as novel target for ADAM-mediated ectodomain shedding and suggest a role of Tim-3 shedding in TLR-mediated immune responses of CD14+ monocytes. PMID:24121505

  19. Study on Karst Rock Desertification by Human-Nature Interaction: A Case Study of Fengshan County of Guangxi, China

    NASA Astrophysics Data System (ADS)

    Zhou, G.; Su, C.; Zhang, R.; Shi, Y.; Liu, Y.; Ma, Y.

    2014-11-01

    Rocky desertification is a process of soil erosion leading to the bareness of bedrock, and is a kind of typical natural disaster in karst areas, which seriously constrains the developments of local society and economy. This paper studies the impact of human activities on the changes of rocky desertification. With the interpretation of remote sensing images of Fengshan County, GuangXi, China covering 1990, 1995 and 2005, this paper analyzes the relationship of the changes of social and economic index (including population density, agricultural population, rural per capital net income, and farmland) and the changes of rocky desertification in recent 15 years. The results indicate that: in recent 15 years, the average annual growth rate of rocky desertification, rate of change of population density, agricultural population, rural per capita net income, and farmland area are 8.7375 km2 /year, 0.7 person/km2.year, 1153 person/year, 85 Yuan/year, and -269.1 ha/year, respectively. The first three of social and economic indicators at different degrees of growth, show a positive correlation with rocky desertification change. However, farmland area, which has been diminishing, shows a negative correlation with rocky desertification. The influence of human activities for karst rocky desertification can be regarded as population growth - steep slope reclamation - the destruction of vegetation - erosion - rocky desertification - poverty.

  20. The inertia of sex: Henry Adams on family and the politics of unconditional love.

    PubMed

    Duff, Brian

    2010-01-01

    This article offers a reassessment of the contemporary relevance of the political thought of Henry Adams through a focus on his ideas about the relationship between family and politics. Adams' ideas have been dismissed by contemporary thinkers, like Richard Rorty, who rely on similar ideas about the role family should play in politics. The article traces the role of ideas about family as a unifying theme in Adams' history, fiction, and autobiography. It shows both why Adams believed familial sentiments, especially feminine and motherly love, were crucial to political unity, and why he thought these sentiments had become increasingly difficult to rely upon. In showing how Adams wrestled with the difficulties that emerge in putting familial sentiments to use for politics, the article suggests that Adams' ideas offer useful lessons for contemporary thinkers interested in the relationship between family and politics.

  1. A substrate-optimized electrophoretic mobility shift assay for ADAM12.

    PubMed

    Kotzsch, Alexander; Skovgaard, Tine; Buus, Uwe; Andersen, Simon; Devkota, Kanchan; Berthelsen, Jens

    2014-05-01

    ADAM12 belongs to the A disintegrin and metalloprotease (ADAM) family of secreted sheddases activating extracellular growth factors such as epidermal growth factor receptor (EGFR) ligands and tumor necrosis factor-alpha (TNF-α). ADAM proteases, most notably ADAM17 (TNF-α-converting enzyme), have long been investigated as pharmaceutical drug targets; however, due to lack of potency and in vivo side effects, none of the small-molecule inhibitors discovered so far has made it beyond clinical testing. Ongoing research on novel selective inhibitors of ADAMs requires reliable biochemical assays to validate molecular probes from large-scale screening efforts. Here we describe an electrophoretic mobility shift assay for ADAM12 based on the identification of an optimized peptide substrate that is characterized by excellent performance and reproducibility.

  2. Terrestrial ecosystem biomonitoring at Rocky Mountain Arsenal

    SciTech Connect

    Roy, R.; Matiatos, D.; Seery, D.; Hetrick, M.; Griess, J.; Henry, C.; Vaughn, S.; Miesner, J.

    1994-12-31

    In 1987 the Fish and Wildlife Service became actively involved in wildlife population monitoring at the Arsenal because of the discovery of a bald eagle roost on the site. Since that time the Service has conducted or funded a variety of investigations to inventory the wildlife species present at the Arsenal and determine their population status. As time progressed and as a result of the passage of the Rocky Mountain Arsenal Refuge legislation in 1992, the Service developed a biomonitoring strategy to determine the current effects of contaminants on terrestrial wildlife resources at the Arsenal and evaluate the efficacy of remediation to ensure the protection and restoration of wildlife resources at the future refuge. This poster will present an overview of the species being studied, measurement and assessment endpoints, strategies, and methods being used by the Service to assess wildlife health as it relates to contaminant exposure.

  3. Rocky Mountain Basins Produced Water Database

    DOE Data Explorer

    Historical records for produced water data were collected from multiple sources, including Amoco, British Petroleum, Anadarko Petroleum Corporation, United States Geological Survey (USGS), Wyoming Oil and Gas Commission (WOGC), Denver Earth Resources Library (DERL), Bill Barrett Corporation, Stone Energy, and other operators. In addition, 86 new samples were collected during the summers of 2003 and 2004 from the following areas: Waltman-Cave Gulch, Pinedale, Tablerock and Wild Rose. Samples were tested for standard seven component "Stiff analyses", and strontium and oxygen isotopes. 16,035 analyses were winnowed to 8028 unique records for 3276 wells after a data screening process was completed. [Copied from the Readme document in the zipped file available at http://www.netl.doe.gov/technologies/oil-gas/Software/database.html] Save the Zipped file to your PC. When opened, it will contain four versions of the database: ACCESS, EXCEL, DBF, and CSV formats. The information consists of detailed water analyses from basins in the Rocky Mountain region.

  4. Ecosystem trends in the Colorado Rockies

    USGS Publications Warehouse

    Stohlgren, T. J.; Baron, J. S.; Kittel, T. G. F.; Binkley, D.

    1995-01-01

    Biological conservation is increasingly moving toward an ecosystem and landscape approach, recognizing the prohibitive cost and difficulty of a species-by-species approach (LaRoe 1993). Also, statewide (e.g., Gap Analysis Program) and national surveys (e.g., Environmental Monitoring and Assessment Program or EMAP) are conducted at a scale and level of resolution that do not meet the needs of most small land-management units that require detailed information at the ecosystem and landscape scale (Stohlgren 1994). The Colorado Rockies are an ideal outdoor laboratory for ecosystem science and management. The escalating environmental threats described in this article compelled us to design a landscape-scale assessment of the status and trends of biotic resources.

  5. Kepler-454b: Rocky or Not?

    NASA Astrophysics Data System (ADS)

    Kohler, Susanna

    2016-02-01

    Small exoplanets tend to fall into two categories: the smallest ones are predominantly rocky, like Earth, and the larger ones have a lower-density, more gaseous composition, similar to Neptune. The planet Kepler-454b was initially estimated to fall between these two groups in radius. So what is its composition?Small-Planet DichotomyThough Kepler has detected thousands of planet candidates with radii between 1 and 2.7 Earth radii, we have only obtained precise mass measurements for 12 of these planets.Mass-radius diagram (click for a closer look!) for planets with radius 2.7 Earth radii and well-measured masses. The six smallest planets (and Venus and Earth) fall along a single mass-radius curve of Earth-like composition. The six larger planets (including Kepler-454b) have lower-density compositions. [Gettel et al. 2016]These measurements, however, show an interesting dichotomy: planets with radii less than 1.6 Earth radii have rocky, Earth-like compositions, following a single relation between their mass and radius. Planets between 2 and 2.7 Earth radii, however, have lower densities and dont follow a single mass-radius relation. Their low densities suggest they contain a significant fraction of volatiles, likely in the form of a thick gas envelope of water, hydrogen, and/or helium.The planet Kepler-454b, discovered transiting a Sun-like star, was initially estimated to have a radius of 1.86 Earth radii placing it in between these two categories. A team of astronomers led by Sara Gettel (Harvard-Smithsonian Center for Astrophysics) have since followed up on the initial Kepler detection, hoping to determine the planets composition.Low-Density OutcomeGettel and collaborators obtained 63 observations of the host stars radial velocity with the HARPS-N spectrograph on the Telescopio Nazionale Galileo, and another 36 observations with the HIRES spectrograph at Keck Observatory. These observations allowed them to do several things:Obtain a more accurate radius estimate

  6. Rocky Mountain spotted fever in Argentina.

    PubMed

    Paddock, Christopher D; Fernandez, Susana; Echenique, Gustavo A; Sumner, John W; Reeves, Will K; Zaki, Sherif R; Remondegui, Carlos E

    2008-04-01

    We describe the first molecular confirmation of Rickettsia rickettsii, the cause of Rocky Mountain spotted fever (RMSF), from a tick vector, Amblyomma cajennense, and from a cluster of fatal spotted fever cases in Argentina. Questing A. cajennense ticks were collected at or near sites of presumed or confirmed cases of spotted fever rickettsiosis in Jujuy Province and evaluated by polymerase chain reaction assays for spotted fever group rickettsiae. DNA of R. rickettsii was amplified from a pool of A. cajennense ticks and from tissues of one of four patients who died during 2003-2004 after illnesses characterized by high fever, severe headache, myalgias, and petechial rash. The diagnosis of spotted fever rickettsiosis was confirmed in the other patients by indirect immunofluorescence antibody and immunohistochemical staining techniques. These findings show the existence of RMSF in Argentina and emphasize the need for clinicians throughout the Americas to consider RMSF in patients with febrile rash illnesses.

  7. Utility of microfossils in Rocky Mountain exploration

    SciTech Connect

    Wornardt, W.W. Jr.

    1983-08-01

    Prior to 1960, exploration geologists in the Rocky Mountain area primarily used lithology, E-logs, geophysics, and a few microfossil groups (fusulinids, invertebrates) for stratigraphic correlations. From 1960 to about 1968, these exploration geologists added several additional groups of microfossils (spores, pollen, and foraminifers) to their tools for correlation. During the past 15 yrs, there has been an explosion in the scientific study of microfossils ranging in age from Cambrian to Holocene. Currently, oil finders are integrating the age-dates and paleoenvironmental information obtained from analyzing 20 different groups of microfossils with the stratigraphy, sedimentology, structure, and geophysical data to create a synergistic exploration program. The addition of micropaleontology and paleoenvironmental data into an exploration program has helped managers make better management decisions, save millions of dollars for the company, and find economical pools of hydrocarbons.

  8. ADAM12: a potential target for the treatment of chronic wounds.

    PubMed

    Harsha, Asheesh; Stojadinovic, Olivera; Brem, Harold; Sehara-Fujisawa, Atsuko; Wewer, Ulla; Loomis, Cynthia A; Blobel, Carl P; Tomic-Canic, Marjana

    2008-08-01

    Wound healing is a complex process involving multiple cellular events, including cell proliferation, migration, and tissue remodeling. A disintegrin and metalloprotease 12 (ADAM12) is a membrane-anchored metalloprotease, which has been implicated in activation-inactivation of growth factors that play an important role in wound healing, including heparin-binding epidermal growth factor (EGF)-like growth factor (HB-EGF) and insulin growth factor (IGF) binding proteins. Here, we report that expression of ADAM12 is fivefold upregulated in the nonhealing edge of chronic ulcers compared to healthy skin, based on microarrays of biopsies taken from five patients and from healthy controls (p = 0.013). The increase in ADAM12 expression in chronic ulcers was confirmed by quantitative real-time polymerase chain reaction (RT-PCR). Moreover, immunohistochemical analysis demonstrated a pronounced increase in the membranous and intracellular signal for ADAM12 in the epidermis of chronic wounds compared to healthy skin. These findings, coupled with our previous observations that lack of keratinocyte migration contributes to the pathogenesis of chronic ulcers, prompted us to evaluate how the absence of ADAM12 affects the migration of mouse keratinocytes. Skin explants from newborn ADAM12-/- or wild-type (WT) mice were used to quantify keratinocyte migration out of the explants over a period of 7 days. We found a statistically significant increase in the migration of ADAM12-/- keratinocytes compared to WT control (p = 0.0014) samples. Taken together, the upregulation of ADAM12 in chronic wounds and the increased migration of keratinocytes in the absence of ADAM12 suggest that ADAM12 is an important mediator of wound healing. We hypothesize that increased expression of ADAM12 in chronic wounds impairs wound healing through the inhibition of keratinocyte migration and that topical ADAM12 inhibitors may therefore prove useful for the treatment of chronic wounds.

  9. Landscape Morphology of the Canadian Rocky Mountains

    NASA Astrophysics Data System (ADS)

    Quinlan, K. T.; Barnes, J. B.; Pavelsky, T.

    2013-12-01

    Glaciers and rivers can significantly modify the shape of mountain landscapes. Following deformation and glaciation, bedrock river form and incision patterns are primarily controlled by variations in geologic structure, the glacial preconditioning of the landscape, and climate. However, the extent to which these factors integrate to affect Holocene patterns and rates of fluvial processes is poorly understood. Fluvial processes dominate the morphology of the Canadian Rocky Mountains today, though the inherited imprint of glaciers remains substantial. This study of fluvial geomorphology in the Athabasca River watershed in Jasper National Park, Alberta, addresses two primary ideas: (1) the fluvial response to deglaciation in alpine environments, and (2) the role of thrust belt geology affecting differential erosion in shaping post-orogenic topography. We use the 0.75 arc-second GeoBase Digital Elevation Model (~18m resolution) to analyze patterns of river concavity (θ) and normalized steepness index (ksn), estimate rock erodibility with field-based proxy measurements, and determine basin-averaged erosion rates using existing river gauge data. We find that bedrock geology and glacial preconditioning exhibit different yet recognizable morphological signatures and that they appear to be related to basin erosion rate. The principal differences we observe include the shape and scale of knickzones, magnitude of channel steepness values, channel concavity patterns, and relationship to bedrock geology. We find that lithologically controlled channel steepness patterns are contained to local spatial scales (<500m) and feature sharp increases in channel steepness at or near contacts between lithologies with differences in measured erodibility. By contrast, glacially controlled steepness patterns are expansive in spatial extent (1-10km), are insensitive to bedrock geology, and have higher overall channel steepness values than areas of lithologically controlled channel steepness

  10. Evaluation of soil fertility in the succession of karst rocky desertification using principal component analysis

    NASA Astrophysics Data System (ADS)

    Xie, L. W.; Zhong, J.; Chen, F. F.; Cao, F. X.; Li, J. J.; Wu, L. C.

    2015-05-01

    Expanding of karst rocky desertification (RD) area in southwestern China is strangling the sustainable development of local agricultural economy. It is important to evaluate the soil fertility at RD regions for the sustainable management of karst lands. The changes in 19 different soil fertility-related variables along a gradient of karst rocky desertification were investigated in five different counties belonging to the central Hunan province in China. We used principal component analysis method to calculate the soil data matrix and obtained a standardized integrate soil fertility (ISF) indicator to reflect RD grades. The results showed that the succession of RD had different impacts on soil fertility indicators. The changing trend of total organic carbon (TOC), total nitrogen (TN), available phosphorus, microbial biomass carbon (MBC), and microbial biomass nitrogen (MBN) was potential RD (PRD) > light RD (LRD) > moderate RD (MRD) > intensive RD (IRD), whereas the changing trend of other indicators was not entirely consistent with the succession of RD. The degradation trend of ISF was basically parallel to the aggravation of RD, and the strength of ISF mean values were in the order of PRD > LRD > MRD > IRD. The TOC, MBC, and MBN could be regarded as the key indicators to evaluate the soil fertility.

  11. 78 FR 14046 - Proposed Establishment of the Moon Mountain District Sonoma County Viticultural Area

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-04

    ... County viticultural area is dominated by the Sonoma Volcanic Group, a series of extrusive igneous rock... these rock formations weather over time, they form rocky soils that provide good drainage for vineyards... geology is dominated by the Franciscan Assemblage, which is composed of sedimentary and metamorphic...

  12. A Disintegrin and Metalloproteinase-12 (ADAM12): Function, Roles in Disease Progression, and Clinical Implications

    PubMed Central

    Nyren-Erickson, Erin K.; Jones, Justin M.; Srivastava, D. K.

    2013-01-01

    Background A disintegrin and metalloproteinase-12 (ADAM12) is a member of the greater ADAM family of enzymes: these are multifunctional, generally membrane-bound, zinc proteases for which there are forty genes known (21 of these appearing in humans). ADAM12 has been implicated in the pathogenesis of various cancers, liver fibrogenesis, hypertension, and asthma, and its elevation or decrease in human serum has been linked to these and other physiological/pathological conditions. Scope In this review, we begin with a brief overview of the ADAM family of enzymes and protein structure. We then discuss the role of ADAM12 in the progression and/or diagnosis of various disease conditions, and we will conclude with an exploration of currently known natural and synthetic inhibitors. Major Conclusions ADAM12 has potential to emerge as a successful drug target, although targeting the metalloproteinase domain with any specificity will be difficult to achieve due to structural similarity between the members of the ADAM and MMP family of enzymes. Overall, more research is required to establish ADAM12 being as a highly desirable biomarker and drug target of different diseases, and their selective inhibitors as potential therapeutic agents. General Significance Given the appearance of elevated levels of ADAM12 in various diseases, particularly breast cancer, our understanding of this enzyme both as a biomarker and a potential drug target could help make significant inroads into both early diagnosis and treatment of disease. PMID:23680494

  13. John Adams's Montesquieuean Moment: Enlightened Historicism in the Discourses on Davila.

    PubMed

    Green, Jonathan

    2016-01-01

    At the outset of the French Revolution John Adams penned a series of Discourses of Davila, philosophical ruminations on the sixteenth-century French Wars of Religion. Recent historians have read these Discourses in terms of Adams's Machiavellianism-his conviction that men's passions lead to violence, if unrestrained. But this reading overlooks the extent to which Adams intended his Discourses as a particular investigation into the French nation's character, and into whether the revolutionaries could lay claim to a native, French tradition of mixed constitutional government. Situating the Discourses vis-à-vis Adams's contemporaneous reading of Montesquieu, this article argues for an underappreciated historicist dimension to his thought.

  14. ADAM10 Is Involved in Cell Junction Assembly in Early Porcine Embryo Development

    PubMed Central

    Kwon, Jeongwoo; Jeong, Sung-min; Choi, Inchul; Kim, Nam-Hyung

    2016-01-01

    ADAM10 (A Disintegrin and Metalloprotease domain-containing protein 10) is a cell surface protein with a unique structure possessing both potential adhesion and protease domains. However, the role of ADAM10 in preimplantation stage embryos is not clear. In this study, we examined the expression patterns and functional roles of ADAM10 in porcine parthenotes during preimplantation development. The transcription level of ADAM10 dramatically increased from the morula stage onward. Immunostaining revealed that ADAM10 was present in both the nucleus and cytoplasm in early cleavage stage embryos, and localized to the apical region of the outer cells in morula and blastocyst embryos. Knockdown (KD) of ADAM10 using double strand RNA did not alter preimplantation embryo development until morula stage, but resulted in significantly reduced development to blastocyst stage. Moreover, the KD blastocyst showed a decrease in gene expression of adherens and tight junction (AJ/TJ), and an increase in trophectoderm TJ permeability by disrupting TJ assembly. Treatment with an ADAM10 specific chemical inhibitor, GI254023X, at the morula stage also inhibited blastocyst development and led to disruption of TJ assembly. An in situ proximity ligation assay demonstrated direct interaction of ADAM10 with coxsackie virus and adenovirus receptor (CXADR), supporting the involvement of ADAM10 in TJ assembly. In conclusion, our findings strongly suggest that ADADM10 is important for blastocyst formation rather than compaction, particularly for TJ assembly and stabilization in preimplantation porcine parthenogenetic development. PMID:27043020

  15. Chemotherapy-induced activation of ADAM-17: a novel mechanism of drug resistance in colorectal cancer

    PubMed Central

    Kyula, Joan N.; Van Schaeybroeck, Sandra; Doherty, Joanne; Fenning, Catherine S.; Longley, Daniel B.; Johnston, Patrick G.

    2010-01-01

    Purpose: We have shown previously that exposure to anticancer drugs can trigger the activation of human epidermal receptor (HER) survival pathways in colorectal cancer (CRC). In this study, we examined the role of ADAMs (a desintegrin and metalloproteases) and soluble growth factors in this acute drug resistance mechanism. Experimental design: In vitro and in vivo models of CRC were assessed. ADAM-17 activity was measured using a fluorometric assay. Ligand shedding was assessed by ELISA or Western blotting. Apoptosis was assessed by flow cytometry and Western blotting. Results: Chemotherapy (5-Fluorouracil, 5-FU) treatment resulted in acute increases in TGF-α-, amphiregulin- and heregulin-ligand shedding in vitro and in vivo that correlated with significantly increased ADAM-17 activity. siRNA-mediated silencing and pharmacological inhibition confirmed that ADAM-17 was the principal ADAM involved in this pro-survival response. Furthermore, overexpression of ADAM-17 significantly decreased the effect of chemotherapy on tumour growth and apoptosis. Mechanistically, we found that ADAM-17 not only regulated phosphorylation of HERs, but also increased the activity of a number of other growth factor receptors, such as IGF-1R and VEGFR. Conclusions: Chemotherapy acutely activates ADAM-17 which results in growth factor shedding, growth factor receptor activation and drug resistance in CRC tumours. Thus, pharmacological inhibition of ADAM-17 in conjunction with chemotherapy may have therapeutic potential for the treatment of CRC. PMID:20570921

  16. ADAM17 cleaves CD16b (FcγRIIIb) in human neutrophils

    PubMed Central

    Wang, Yue; Wu, Jianming; Newton, Robert; Bahaie, Nooshin S.; Long, Chunmei; Walcheck, Bruce

    2012-01-01

    CD16b (FcγRIIIb) is exclusively expressed by human neutrophils and binds IgG in immune complexes. Cell surface CD16b undergoes efficient ectodomain shedding upon neutrophil activation and apoptosis. Indeed, soluble CD16b is present at high levels in the plasma of healthy individuals, which appears to be maintained by the daily turnover of apoptotic neutrophils. At this time, the principal protease responsible for CD16b shedding is not known. We show that CD16b plasma levels were significantly decreased in patients administered a selective inhibitor targeting the metalloproteases ADAM10 and ADAM17. Additional analysis with inhibitors selective for ADAM10 or ADAM17 revealed that only inhibition of ADAM17 significantly blocked the cleavage of CD16b following neutrophil activation and apoptosis. CD16b shedding by ADAM17 was further demonstrated using a unique ADAM17 function-blocking mAb and a cell-based ADAM17 reconstitution assay. Unlike human CD16, however, mouse CD16 did not undergo efficient ectodomain shedding upon neutrophil stimulation or apoptosis, indicating that this mechanism cannot be modeled in normal mice. Taken together, our findings are the first to directly demonstrate that ADAM17 cleaves CD16 in human leukocytes. PMID:23228566

  17. ADAM10 Is Involved in Cell Junction Assembly in Early Porcine Embryo Development.

    PubMed

    Kwon, Jeongwoo; Jeong, Sung-min; Choi, Inchul; Kim, Nam-Hyung

    2016-01-01

    ADAM10 (A Disintegrin and Metalloprotease domain-containing protein 10) is a cell surface protein with a unique structure possessing both potential adhesion and protease domains. However, the role of ADAM10 in preimplantation stage embryos is not clear. In this study, we examined the expression patterns and functional roles of ADAM10 in porcine parthenotes during preimplantation development. The transcription level of ADAM10 dramatically increased from the morula stage onward. Immunostaining revealed that ADAM10 was present in both the nucleus and cytoplasm in early cleavage stage embryos, and localized to the apical region of the outer cells in morula and blastocyst embryos. Knockdown (KD) of ADAM10 using double strand RNA did not alter preimplantation embryo development until morula stage, but resulted in significantly reduced development to blastocyst stage. Moreover, the KD blastocyst showed a decrease in gene expression of adherens and tight junction (AJ/TJ), and an increase in trophectoderm TJ permeability by disrupting TJ assembly. Treatment with an ADAM10 specific chemical inhibitor, GI254023X, at the morula stage also inhibited blastocyst development and led to disruption of TJ assembly. An in situ proximity ligation assay demonstrated direct interaction of ADAM10 with coxsackie virus and adenovirus receptor (CXADR), supporting the involvement of ADAM10 in TJ assembly. In conclusion, our findings strongly suggest that ADADM10 is important for blastocyst formation rather than compaction, particularly for TJ assembly and stabilization in preimplantation porcine parthenogenetic development.

  18. Increase of α-Secretase ADAM10 in Platelets Along Cognitively Healthy Aging.

    PubMed

    Schuck, Florian; Wolf, Dominik; Fellgiebel, Andreas; Endres, Kristina

    2016-01-01

    ADAM10 is one of the key players in ectodomain-shedding of the amyloid-β protein precursor (AβPP). Previous research with postmortem tissue has shown reduced expression and activity of ADAM10 within the central nervous system (CNS) of Alzheimer's disease (AD) patients. Determination of cerebral ADAM10 in living humans is hampered by its transmembrane property; only the physiological AβPP cleavage product generated by ADAM10, sAβPPα, can be assessed in cerebrospinal fluid. Establishment of surrogate markers in easily accessible material therefore is crucial. It has been demonstrated that ADAM10 is expressed in platelets and that platelet amount is decreased in AD patients. Just recently it has been shown that platelet ADAM10 and cognitive performance of AD patients positively correlate. In contrast to AD patients, to our knowledge almost no information has been published regarding ADAM10 expression during normal aging. We investigated ADAM10 amount and activity in platelets of cognitively healthy individuals from three different age groups ranging from 22-85 years. Interestingly, we observed an age-dependent increase in ADAM10 levels and activity in platelets.

  19. ADAM19: A Novel Target for Metabolic Syndrome in Humans and Mice

    PubMed Central

    Weerasekera, Lakshini; Rudnicka, Caroline; Sang, Qing-Xiang; Johnson, Matthew P.; Moses, Eric K.; Göring, Harald H. H.; Blangero, John; Hricova, Jana; Schlaich, Markus

    2017-01-01

    Obesity is one of the most prevalent metabolic diseases in the Western world and correlates directly with insulin resistance, which may ultimately culminate in type 2 diabetes (T2D). We sought to ascertain whether the human metalloproteinase A Disintegrin and Metalloproteinase 19 (ADAM19) correlates with parameters of the metabolic syndrome in humans and mice. To determine the potential novel role of ADAM19 in the metabolic syndrome, we first conducted microarray studies on peripheral blood mononuclear cells from a well-characterised human cohort. Secondly, we examined the expression of ADAM19 in liver and gonadal white adipose tissue using an in vivo diet induced obesity mouse model. Finally, we investigated the effect of neutralising ADAM19 on diet induced weight gain, insulin resistance in vivo, and liver TNF-α levels. Significantly, we show that, in humans, ADAM19 strongly correlates with parameters of the metabolic syndrome, particularly BMI, relative fat, HOMA-IR, and triglycerides. Furthermore, we identified that ADAM19 expression was markedly increased in the liver and gonadal white adipose tissue of obese and T2D mice. Excitingly, we demonstrate in our diet induced obesity mouse model that neutralising ADAM19 therapy results in weight loss, improves insulin sensitivity, and reduces liver TNF-α levels. Our novel data suggest that ADAM19 is pro-obesogenic and enhances insulin resistance. Therefore, neutralisation of ADAM19 may be a potential therapeutic approach to treat obesity and T2D. PMID:28265178

  20. Molecular characterization and expression analysis of ADAM12 during chicken embryonic development.

    PubMed

    Lin, Juntang; Luo, Jiankai; Redies, Christoph

    2010-12-01

    ADAM12 is a member of the disintegrin and metalloprotease (ADAM) family of molecules, which consist of multiple domains. ADAM12 is involved in different physiological and pathological processes. In the present study, full-length sequences of two chicken ADAM12 isoforms were cloned and identified by reverse transcription-polymerase chain reaction (RT-PCR), rapid amplification of cDNA ends methods and bioinformatics analysis. The long isoform consists of all domains characteristic for ADAMs and is strongly expressed in different tissues, whereas the short isoform lacks large parts of the metalloprotease and disintegrin domains and is only expressed weakly. Results from semi-quantitative RT-PCR show that the complete ADAM12 is stably expressed throughout chicken embryonic development, while the short isoform is only regionally detectable in the lung and brain. Results from in situ hybridization show that chicken ADAM12 is expressed exclusively in tissues and organs derived from the neural tube, the neural crest or the mesoderm, with a highly regulated spatiotemporal expression pattern. Our data confirm and extend studies of ADAM12 in other species, and suggest that ADAM12 may play a role in the development of several organs, including the formation of feather buds.

  1. ADAM12-deficient zebrafish exhibit retardation in body growth at the juvenile stage without developmental defects.

    PubMed

    Tokumasu, Yudai; Iida, Atsuo; Wang, Zi; Ansai, Satoshi; Kinoshita, Masato; Sehara-Fujisawa, Atsuko

    2016-05-01

    ADAM (a disintegrin and metalloprotease) constitutes a family of multi-domain proteins that are involved in development, homeostasis, and disease. ADAM12 plays important roles in myogenesis and adipogenesis in mice; however, the precise physiological mechanisms are not known, and the function of this gene in other vertebrates has not been examined. In this study, we used a simple model vertebrate, the zebrafish, to investigate the functions of ADAM12 during development. Zebrafish adam12 is conserved with those of mammals in the synteny and the amino-acid sequence. We examined adam12 expression in zebrafish embryos by whole mount in situ hybridization and the promoter activity of the adam12 upstream sequence. We found that adam12 is strongly expressed in the cardiovascular system, erythroid progenitors, brain, and jaw cartilage during zebrafish development, and adam12-knockout zebrafish exhibited reduced body size in the juvenile stage without apparent morphological defects. Taken together, these results suggest that adam12 plays a significant role in the regulation of body growth during juvenile stage in zebrafish, although the precise molecular mechanisms await further study.

  2. Metalloprotease-disintegrin ADAM12 expression is regulated by Notch signaling via microRNA-29.

    PubMed

    Li, Hui; Solomon, Emilia; Duhachek Muggy, Sara; Sun, Danqiong; Zolkiewska, Anna

    2011-06-17

    Metalloprotease-disintegrin ADAM12 is overexpressed and frequently mutated in breast cancer. We report here that ADAM12 expression in cultured mammalian cells is up-regulated by Notch signals. Expression of a constitutively active form of Notch1 in murine fibroblasts, myoblasts, or mammary epithelial cells or activation of the endogenous Notch signaling by co-culture with ligand-expressing cells increases ADAM12 protein and mRNA levels. Up-regulation of ADAM12 expression by Notch requires new transcription, is activated in a CSL-dependent manner, and is abolished upon inhibition of IκB kinase. Expression of a constitutively active Notch1 in NIH3T3 cells increases the stability of Adam12 mRNA. We further show that the microRNA-29 family, which has a predicted conserved site in the 3'-untranslated region of mouse Adam12, plays a critical role in mediating the stimulatory effect of Notch on ADAM12 expression. In human cells, Notch up-regulates the expression of the long form, but not the short form, of ADAM12 containing a divergent 3'-untranslated mRNA region. These studies uncover a novel paradigm in Notch signaling and establish Adam12 as a Notch-related gene.

  3. Rocky core solubility in Jupiter and giant exoplanets.

    PubMed

    Wilson, Hugh F; Militzer, Burkhard

    2012-03-16

    Gas giants are believed to form by the accretion of hydrogen-helium gas around an initial protocore of rock and ice. The question of whether the rocky parts of the core dissolve into the fluid H-He layers following formation has significant implications for planetary structure and evolution. Here we use ab initio calculations to study rock solubility in fluid hydrogen, choosing MgO as a representative example of planetary rocky materials, and find MgO to be highly soluble in H for temperatures in excess of approximately 10,000 K, implying the potential for significant redistribution of rocky core material in Jupiter and larger exoplanets.

  4. Recent eruptions of Mount Adams, Washington Cascades, USA

    USGS Publications Warehouse

    Hildreth, Wes; Fierstein, Judy

    1997-01-01

    The postglacial eruption rate for the Mount Adams volcanic field is ∼0.1 km3/k.y., four to seven times smaller than the average rate for the past 520 k.y. Ten vents have been active since the last main deglaciation ∼15 ka. Seven high flank vents (at 2100-2600 m) and the central summit vent of the 3742-m stratocone produced varied andesites, and two peripheral vents (at 2100 and 1200 m) produced mildly alkalic basalt. Eruptive ages of most of these units are bracketed with respect to regional tephra layers from Mount Mazama and Mount St. Helens. The basaltic lavas and scoria cones north and south of Mount Adams and a 13-km-long andesitic lava flow on its east flank are of early postglacial age. The three most extensive andesitic lava-flow complexes were emplaced in the mid-Holocene (7-4 ka). Ages of three smaller Holocene andesite units are less well constrained. A phreatomagmatic ejecta cone and associated andesite lavas that together cap the summit may be of latest Pleistocene age. but a thin layer of mid-Holocene tephra appears to have erupted there as well. An alpine-meadow section on the southeast flank contains 24 locally derived Holocene andesitic ash layers intercalated with several silicic tephras from Mazama and St. Helens. Microprobe analyses of phenocrysts from the ash layers and postglacial lavas suggest a few correlations and refine some age constraints. Approximately 6 ka, a 0.07-km3 debris avalanche from the southwest face of Mount Adams gen-erated a clay-rich debris flow that devastated >30 km2 south of the volcano. A gravitationally metastable 2-to 3-km3 reservoir of hydrothermally altered fragmental andesite remains on the ice-capped summit and, towering 3 km above the surrounding lowlands, represents a greater hazard than an eruptive recurrence in the style of the last 15 k.y.

  5. Lance–Adams syndrome: A special case of a mother

    PubMed Central

    Nigam, Gaurav Bhaskar; Babu, Sachin Suresh; Peter, C. Sudhir; Peter, C. Shobhna

    2016-01-01

    Predicting the neurological outcome in survivors of cardiorespiratory arrest is difficult. A distinction has been made between acute and chronic posthypoxic myoclonus, called myoclonic status epilepticus and Lance–Adams syndrome (LAS), respectively, with the acute condition carrying a bad prognosis. Here, we report a case of a 37-year-old female who developed seizures after a successful cardiopulmonary resuscitation. The available literature on such cases is very rare and has generally mentioned a poor outcome. However, our patient was successfully managed and showed clinical features of LAS. Thus, making an early diagnosis and proper management of hypoxic brain insults is positively related to improving the patient's functional outcome. PMID:27688633

  6. Simulation of Naval Guns' Breechblock System Dynamics Based on ADAMS

    NASA Astrophysics Data System (ADS)

    Tan, Bo; Liu, Hui-Min; Liu, Kai

    In order to study the dynamical characteristics of the breechblock system during gun firing, a virtual prototype model was established based on ADAMS, in which motion and force transmission among mechanisms are realized by collision. By simulation, kinematics and dynamics properties of main components are obtained, and the relationships between the motion of breechblock and the position of breechblock opening plate are analyzed. According to the simulation results, the collision among the breechblock opening plate and the roller is discontinuous, which may make the breechblock system fail to hitch the breechblock reliably. And within allowable scope of the structure, the breechblock opening template should be installed near the upside as much as possible.

  7. Applying the Adams influence model in nurse executive practice.

    PubMed

    Adams, Jeffrey M; Erickson, Jeanette Ives

    2011-04-01

    The ability to influence others is a required competency for nurse executives trying to achieve positive patient/organizational outcomes. The Adams Influence Model (AIM) is a framework for understanding the factors, attributes, and process of influence. The AIM is grounded in nursing and organizational literature and provides nurse leaders with a road map for developing an effective strategy to achieve influence with individuals and/or groups. The authors describe the AIM and present a case study illustrating its application by a chief nurse executive.

  8. The "delivery" of Adam: a medical interpretation of Michelangelo.

    PubMed

    Di Bella, Stefano; Taglietti, Fabrizio; Iacobuzio, Andrea; Johnson, Emma; Baiocchini, Andrea; Petrosillo, Nicola

    2015-04-01

    This article describes what we believe to be the key to interpreting the concept represented by Michelangelo's painting the Creation of Adam. This fresco, one of his most famous masterpieces, is situated in the heart of the Sistine Chapel and is viewed by millions of people every year. A man of many talents, Michelangelo's proficiency in anatomical dissection is reflected in his artwork. As such, analyses of hidden meanings in this fresco have been ascribed, including the concept of the "Brain-God." However, we see a postpartum uterus and adjacent anatomy, justifying our interpretation that Michelangelo was depicting something far more fundamental: the birth of mankind.

  9. MOUNT ADAMS WILDERNESS AND CONTIGUOUS ROADLESS AREAS, WASHINGTON.

    USGS Publications Warehouse

    Hildreth, Wes; Miller, M.

    1984-01-01

    There is little likelihood for the occurrence of metallic mineral or energy resources based on a mineral survey in 1981-82 in the Mount Adams Wilderness and contiguous roadless areas, Washington. No mining claims exist in the study area, which is almost entirely a young andesitic stratovolcano. There is no indication of a shallow magma reservoir capable of supporting a convective geothermal system. Drilling in the lowland periphery of the volcano might be technically difficult, but 150 degree -200 degree F waters suitable for space heating would not be unexpected at depths of 5000-6000 ft.

  10. 75 FR 81641 - Odessa Subarea Special Study; Adams, Franklin, Grant, and Lincoln Counties, WA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-28

    ... Carnohan, Activity Manager, 1917 Marsh Road, Yakima, Washington 98901- 2058. Comments may also be submitted electronically to Odessa@usbr.gov . FOR FURTHER INFORMATION: Contact Charles Carnohan, Activity Manager... North 10th Avenue, Pasco, WA 99301. Big Bend Community College Library, Building 1800, 7611...

  11. Archaeological Evaluation of Proposed Dredge Disposal Site, Lock and Dam Number 20, Adams County, Illinois.

    DTIC Science & Technology

    1987-03-01

    adjacent to Indian Grave Lake. Several sand dunes were tested here and a deep midden was noted in the shore of the lake (Thomas 1894:121). This lake is...ceramics also were found. It is likely that these small items fell through or between the boards, forming a thin midden under the structure’s floor. A dark...not clear in the area east and south of these posts. A midden or sructure basin may exist there, but further investigations are needed to define

  12. 76 FR 45600 - Columbia National Wildlife Refuge, Adams and Grant Counties, WA; Draft Comprehensive Conservation...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-29

    ... opportunities for hunting, fishing, wildlife observation and photography, and environmental education and... compatible public uses include hunting, fishing, wildlife photography and observation, and environmental... on compatible wildlife observation, photography, and interpretation. The Sandhill Crane...

  13. How is Pluto Classified as a Rocky World?

    NASA Video Gallery

    When it comes to Pluto, classification is tricky, but it’s unquestioningly a rocky body. This is Pluto in a Minute. The bodies in our solar system fall more or less into set categories like gas g...

  14. Why sulfonamides are contraindicated in Rocky Mountain spotted fever.

    PubMed

    Ren, Vicky; Hsu, Sylvia

    2014-02-18

    Sulfonamide antibiotics are not effective for the treatment of Rocky Mountain spotted fever (RMSF). Patients suspected of having RMSF based on history and physical exam should be treated with doxycycline and not a sulfonamide to avoid increased morbidity and mortality.

  15. ADAM10 Is the Major Sheddase Responsible for the Release of Membrane-associated Meprin A*

    PubMed Central

    Herzog, Christian; Haun, Randy S.; Ludwig, Andreas; Shah, Sudhir V.; Kaushal, Gur P.

    2014-01-01

    Meprin A, composed of α and β subunits, is a membrane-bound metalloproteinase in renal proximal tubules. Meprin A plays an important role in tubular epithelial cell injury during acute kidney injury (AKI). The present study demonstrated that during ischemia-reperfusion-induced AKI, meprin A was shed from proximal tubule membranes, as evident from its redistribution toward the basolateral side, proteolytic processing in the membranes, and excretion in the urine. To identify the proteolytic enzyme responsible for shedding of meprin A, we generated stable HEK cell lines expressing meprin β alone and both meprin α and meprin β for the expression of meprin A. Phorbol 12-myristate 13-acetate and ionomycin stimulated ectodomain shedding of meprin β and meprin A. Among the inhibitors of various proteases, the broad spectrum inhibitor of the ADAM family of proteases, tumor necrosis factor-α protease inhibitor (TAPI-1), was most effective in preventing constitutive, phorbol 12-myristate 13-acetate-, and ionomycin-stimulated shedding of meprin β and meprin A in the medium of both transfectants. The use of differential inhibitors for ADAM10 and ADAM17 indicated that ADAM10 inhibition is sufficient to block shedding. In agreement with these results, small interfering RNA to ADAM10 but not to ADAM9 or ADAM17 inhibited meprin β and meprin A shedding. Furthermore, overexpression of ADAM10 resulted in enhanced shedding of meprin β from both transfectants. Our studies demonstrate that ADAM10 is the major ADAM metalloproteinase responsible for the constitutive and stimulated shedding of meprin β and meprin A. These studies further suggest that inhibiting ADAM 10 activity could be of therapeutic benefit in AKI. PMID:24662289

  16. Metalloproteinases ADAM12 and MMP-14 are associated with cavernous sinus invasion in pituitary adenomas.

    PubMed

    Wang, Junwen; Voellger, Benjamin; Benzel, Julia; Schlomann, Uwe; Nimsky, Christopher; Bartsch, Jörg W; Carl, Barbara

    2016-09-15

    Invasion of tumor cells critically depends on cell-cell or cell-extracellular matrix interactions. Enzymes capable of modulating these interactions belong to the proteinase families of ADAM (a disintegrin and metalloprotease) and MMP (matrix metalloprotease) proteins. Our objective is to examine their expression levels and evaluate the relationship between expression levels and cavernous sinus invasion in pituitary adenomas. Tissue samples from 35 patients with pituitary adenomas were analyzed. Quantitative real-time polymerase chain reaction (qPCR) was employed to assess mRNA expression levels for ADAM and MMP genes. Protein levels were examined using immunohistochemistry and Western Blot. Correlation analyses between expression levels and clinical parameters were performed. By silencing ADAM12 and MMP-14 with siRNA in a mouse pituitary adenoma cell line (TtT/GF), their cellular effects were investigated. In our study, nine women and 26 men were included, with a mean age of 53.1 years (range 15-84 years) at the time of surgery. There were 19 cases with cavernous sinus invasion. The proteins ADAM12 and MMP-14 were significantly up-regulated in invasive adenomas compared to noninvasive adenomas. Both human isoforms of ADAM12 (ADAM12L and ADAM12s) were involved in tumor invasion; moreover, ADAM12L was found to correlate positively with Ki-67 proliferation index in pituitary adenomas. In TtT/GF pituitary adenoma cells, silencing of ADAM12 and MMP-14 significantly inhibited cell invasion and migration, respectively, whereas only silencing of ADAM12 suppressed cell proliferation. We conclude that ADAM12 and MMP-14 are associated with cavernous sinus invasion in pituitary adenomas, which qualifies these proteins in diagnosis and therapy.

  17. RACK1, a new ADAM12 interacting protein. Contribution to liver fibrogenesis.

    PubMed

    Bourd-Boittin, Katia; Le Pabic, Hélène; Bonnier, Dominique; L'Helgoualc'h, Annie; Théret, Nathalie

    2008-09-19

    ADAM12 belongs to a disintegrin-like and metalloproteinase-containing protein family that possesses multidomain structures composed of a pro-domain, a metalloprotease, disintegrin-like, cysteine-rich, epidermal growth factor-like, and transmembrane domains, and a cytoplasmic tail. Overexpression of several ADAMs has been reported in human cancer, and we recently described the involvement of ADAM12 in liver injury (Le Pabic, H., Bonnier, D., Wewer, U. M., Coutand, A., Musso, O., Baffet, G., Clement, B., and Theret, N. (2003) Hepatology 37, 1056-1066). In this study, we used a yeast two-hybrid screening of a cDNA library from human hepatocellular carcinoma to analyze binding partners of ADAM12. We identify RACK1, a receptor for activated protein kinase C (PKC), as a new ADAM12 interacting protein. RACK1 is up-regulated in patients with hepatocellular carcinoma and is highly expressed by activated hepatic stellate cells. We demonstrate the involvement of RACK1 in mediating the PKC-dependent translocation of ADAM12 to membranes of activated hepatic stellate cells. In particular, treatment of cells with phorbol esters enhances ADAM12 immunostaining in the membrane fractions and the co-immunoprecipitation of ternary complexes containing RACK1, ADAM12, and PKC. By using RNA interference, we demonstrate that inhibition of RACK1 expression diminishes the phorbol 12-myristate 13-acetate-dependent translocation of ADAM12 to membranes of hepatic stellate cells. Finally, hepatic stellate cells cultured on coated type I collagen induces relocalization of ADAM12 in the membrane, suggesting that this major matrix component in liver cancer and fibrogenesis might stimulate ADAM12 translocation to the cell membrane where its shedding activity takes place.

  18. The oldest known Rocky Mountain bristlecone pines (Pinus aristata Engelm.)

    USGS Publications Warehouse

    Brunstein, F.C.; Yamaguchi, D.K.

    1992-01-01

    The authors have found 12 living Rocky Mountain bristlecone pines >1600 yr old, including four that are >2100 yr old, on Black Mountain, near South Park, and on Almagre Mountain, in the S Front Range, Colorado. A core from the oldest of these trees has an inner-ring date of 442 BC. This tree is therefore at least 2435 yr old and exceeds the age of the oldest previously reported Rocky Mountain bristlecone pine by 846 yr. -from Authors

  19. Kepler's First Rocky Planet: Kepler-10b

    NASA Astrophysics Data System (ADS)

    Batalha, Natalie M.; Borucki, William J.; Bryson, Stephen T.; Buchhave, Lars A.; Caldwell, Douglas A.; Christensen-Dalsgaard, Jørgen; Ciardi, David; Dunham, Edward W.; Fressin, Francois; Gautier, Thomas N., III; Gilliland, Ronald L.; Haas, Michael R.; Howell, Steve B.; Jenkins, Jon M.; Kjeldsen, Hans; Koch, David G.; Latham, David W.; Lissauer, Jack J.; Marcy, Geoffrey W.; Rowe, Jason F.; Sasselov, Dimitar D.; Seager, Sara; Steffen, Jason H.; Torres, Guillermo; Basri, Gibor S.; Brown, Timothy M.; Charbonneau, David; Christiansen, Jessie; Clarke, Bruce; Cochran, William D.; Dupree, Andrea; Fabrycky, Daniel C.; Fischer, Debra; Ford, Eric B.; Fortney, Jonathan; Girouard, Forrest R.; Holman, Matthew J.; Johnson, John; Isaacson, Howard; Klaus, Todd C.; Machalek, Pavel; Moorehead, Althea V.; Morehead, Robert C.; Ragozzine, Darin; Tenenbaum, Peter; Twicken, Joseph; Quinn, Samuel; VanCleve, Jeffrey; Walkowicz, Lucianne M.; Welsh, William F.; Devore, Edna; Gould, Alan

    2011-03-01

    NASA's Kepler Mission uses transit photometry to determine the frequency of Earth-size planets in or near the habitable zone of Sun-like stars. The mission reached a milestone toward meeting that goal: the discovery of its first rocky planet, Kepler-10b. Two distinct sets of transit events were detected: (1) a 152 ± 4 ppm dimming lasting 1.811 ± 0.024 hr with ephemeris T [BJD] =2454964.57375+0.00060 -0.00082 + N*0.837495+0.000004 -0.000005 days and (2) a 376 ± 9 ppm dimming lasting 6.86 ± 0.07 hr with ephemeris T [BJD] =2454971.6761+0.0020 -0.0023 + N*45.29485+0.00065 -0.00076 days. Statistical tests on the photometric and pixel flux time series established the viability of the planet candidates triggering ground-based follow-up observations. Forty precision Doppler measurements were used to confirm that the short-period transit event is due to a planetary companion. The parent star is bright enough for asteroseismic analysis. Photometry was collected at 1 minute cadence for >4 months from which we detected 19 distinct pulsation frequencies. Modeling the frequencies resulted in precise knowledge of the fundamental stellar properties. Kepler-10 is a relatively old (11.9 ± 4.5 Gyr) but otherwise Sun-like main-sequence star with T eff = 5627 ± 44 K, M sstarf = 0.895 ± 0.060 M sun, and R sstarf = 1.056 ± 0.021 R sun. Physical models simultaneously fit to the transit light curves and the precision Doppler measurements yielded tight constraints on the properties of Kepler-10b that speak to its rocky composition: M P = 4.56+1.17 -1.29 M ⊕, R P = 1.416+0.033 -0.036 R ⊕, and ρP = 8.8+2.1 -2.9 g cm-3. Kepler-10b is the smallest transiting exoplanet discovered to date. Based in part on observations obtained at the W. M. Keck Observatory, which is operated by the University of California and the California Institute of Technology.

  20. Photocopy of panoramic photograph entitled "Ground Breaking, April 27, 1918, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of panoramic photograph entitled "Ground Breaking, April 27, 1918, U.S.A. General Hospital no. 21…". Photograph by Rocky Mountain photo and is in the Fitzsimons Army Medical Center Public Affairs Office, building 120. Photograph in public domain as it is not copyrighted. - Fitzsimons General Hospital, Bounded by East Colfax to south, Peoria Street to west, Denver City/County & Adams County Line to north, & U.S. Route 255 to east, Aurora, Adams County, CO

  1. The futility of utility: how market dynamics marginalize Adam Smith

    NASA Astrophysics Data System (ADS)

    McCauley, Joseph L.

    2000-10-01

    Economic theorizing is based on the postulated, nonempiric notion of utility. Economists assume that prices, dynamics, and market equilibria are supposed to be derived from utility. The results are supposed to represent mathematically the stabilizing action of Adam Smith's invisible hand. In deterministic excess demand dynamics I show the following. A utility function generally does not exist mathematically due to nonintegrable dynamics when production/investment are accounted for, resolving Mirowski's thesis. Price as a function of demand does not exist mathematically either. All equilibria are unstable. I then explain how deterministic chaos can be distinguished from random noise at short times. In the generalization to liquid markets and finance theory described by stochastic excess demand dynamics, I also show the following. Market price distributions cannot be rescaled to describe price movements as ‘equilibrium’ fluctuations about a systematic drift in price. Utility maximization does not describe equilibrium. Maximization of the Gibbs entropy of the observed price distribution of an asset would describe equilibrium, if equilibrium could be achieved, but equilibrium does not describe real, liquid markets (stocks, bonds, foreign exchange). There are three inconsistent definitions of equilibrium used in economics and finance, only one of which is correct. Prices in unregulated free markets are unstable against both noise and rising or falling expectations: Adam Smith's stabilizing invisible hand does not exist, either in mathematical models of liquid market data, or in real market data.

  2. The shedding activity of ADAM17 is sequestered in lipid rafts

    SciTech Connect

    Tellier, Edwige; Canault, Matthias; Rebsomen, Laure; Bonardo, Bernadette; Juhan-Vague, Irene; Nalbone, Gilles; Peiretti, Franck . E-mail: Franck.Peiretti@medecine.univ-mrs.fr

    2006-12-10

    The tumor necrosis factor-alpha (TNF) converting enzyme (ADAM17) is a metalloprotease-disintegrin responsible for the cleavage of several biologically active transmembrane proteins. However, the substrate specificity of ADAM17 and the regulation of its shedding activity are still poorly understood. Here, we report that during its transport through the Golgi apparatus, ADAM17 is included in cholesterol-rich membrane microdomains (lipid rafts) where its prodomain is cleaved by furin. Consequently, ADAM17 shedding activity is sequestered in lipid rafts, which is confirmed by the fact that metalloproteinase inhibition increases the proportion of ADAM17 substrates (TNF and its receptors TNFR1 and TNFR2) in lipid rafts. Membrane cholesterol depletion increases the ADAM17-dependent shedding of these substrates demonstrating the importance of lipid rafts in the control of this process. Furthermore, ADAM17 substrates are present in different proportions in lipid rafts, suggesting that the entry of each of these substrates in these particular membrane microdomains is specifically regulated. Our data support the idea that one of the mechanisms regulating ADAM17 substrate cleavage involves protein partitioning in lipid rafts.

  3. ADAM8 expression in invasive breast cancer promotes tumor dissemination and metastasis

    PubMed Central

    Romagnoli, Mathilde; Mineva, Nora D; Polmear, Michael; Conrad, Catharina; Srinivasan, Srimathi; Loussouarn, Delphine; Barillé-Nion, Sophie; Georgakoudi, Irene; Dagg, Áine; McDermott, Enda W; Duffy, Michael J; McGowan, Patricia M; Schlomann, Uwe; Parsons, Maddy; Bartsch, Jörg W; Sonenshein, Gail E

    2014-01-01

    The transmembrane metalloprotease-disintegrin ADAM8 mediates cell adhesion and shedding of ligands, receptors and extracellular matrix components. Here, we report that ADAM8 is abundantly expressed in breast tumors and derived metastases compared to normal tissue, especially in triple-negative breast cancers (TNBCs). Furthermore, high ADAM8 levels predicted poor patient outcome. Consistently, ADAM8 promoted an aggressive phenotype of TNBC cells in culture. In a mouse orthotopic model, tumors derived from TNBC cells with ADAM8 knockdown failed to grow beyond a palpable size and displayed poor vascularization. Circulating tumor cells and brain metastases were also significantly reduced. Mechanistically, ADAM8 stimulated both angiogenesis through release of VEGF-A and transendothelial cell migration via β1-integrin activation. In vivo, treatment with an anti-ADAM8 antibody from the time of cell inoculation reduced primary tumor burden and metastases. Furthermore, antibody treatment of established tumors profoundly decreased metastases in a resection model. As a non-essential protein under physiological conditions, ADAM8 represents a promising novel target for treatment of TNBCs, which currently lack targeted therapies and frequently progress with fatal dissemination. Subject Category Cancer PMID:24375628

  4. Role of MicroRNA-103a Targeting ADAM10 in Abdominal Aortic Aneurysm

    PubMed Central

    Jiao, Tong; Yao, Ye; Zhang, Bo; Sun, Qing-Feng; Li, Jing-Bo; Yuan, Chao; Jing, Bao; Wang, Yun-Peng

    2017-01-01

    MicroRNAs (miRNAs) are deregulated in various vascular ailments including abdominal aortic aneurysm (AAA). MiR-103 is involved in vascular, metabolic, and malignant diseases, but whether it participates in the pathogenesis of AAA remains elusive. ADAM10 plays a vital role in the formation of aneurysm, but whether miRs modulate its activity during AAA formation is totally unknown. In this study, we detected the significantly increased protein expression of ADAM10 in angiotensin II induced murine AAA specimens, while the mRNA expression of ADAM10 was similar between AAA and control, suggesting the posttranscriptional regulation. The ADAM10 specific inhibitor GI254023X dramatically reduced the macrophage infiltration of murine abdominal aorta. Bioinformatic predictions suggest that ADAM10 is the target of miR-103a/107 but the binding site is exclusive. At the cellular level, miR-103a-1 suppressed the protein expression of ADAM10, while antisense miR-103a-1 increased its expression. Particularly, with the progression of murine AAA, the mRNA expression of miR-103a/107 substantially decreased and the protein expression of ADAM10 greatly increased. Together, our data afford the new insight that miR-103a inhibited AAA growth via targeting ADAM10, which might be a promising therapeutic strategy to alleviate AAA. PMID:28357407

  5. Role of MicroRNA-103a Targeting ADAM10 in Abdominal Aortic Aneurysm.

    PubMed

    Jiao, Tong; Yao, Ye; Zhang, Bo; Hao, Da-Cheng; Sun, Qing-Feng; Li, Jing-Bo; Yuan, Chao; Jing, Bao; Wang, Yun-Peng; Wang, Hai-Yang

    2017-01-01

    MicroRNAs (miRNAs) are deregulated in various vascular ailments including abdominal aortic aneurysm (AAA). MiR-103 is involved in vascular, metabolic, and malignant diseases, but whether it participates in the pathogenesis of AAA remains elusive. ADAM10 plays a vital role in the formation of aneurysm, but whether miRs modulate its activity during AAA formation is totally unknown. In this study, we detected the significantly increased protein expression of ADAM10 in angiotensin II induced murine AAA specimens, while the mRNA expression of ADAM10 was similar between AAA and control, suggesting the posttranscriptional regulation. The ADAM10 specific inhibitor GI254023X dramatically reduced the macrophage infiltration of murine abdominal aorta. Bioinformatic predictions suggest that ADAM10 is the target of miR-103a/107 but the binding site is exclusive. At the cellular level, miR-103a-1 suppressed the protein expression of ADAM10, while antisense miR-103a-1 increased its expression. Particularly, with the progression of murine AAA, the mRNA expression of miR-103a/107 substantially decreased and the protein expression of ADAM10 greatly increased. Together, our data afford the new insight that miR-103a inhibited AAA growth via targeting ADAM10, which might be a promising therapeutic strategy to alleviate AAA.

  6. DEVELOPMENT OF THE HUMAN LUNG MEASURED BY AEROSOL-DERIVED AIRWAY MORPHEMETRY (ADAM).

    EPA Science Inventory

    We measured, in vivo, the airspace calibers of the small airways and alveoli by ADAM in the lungs of children of ages 6 to 18 years and adults aged 18 to 80 years. ADAM utilizes the gravitational settling time of inhaled monodisperse particles to infer the vertical distance to th...

  7. ADAM8 expression in invasive breast cancer promotes tumor dissemination and metastasis.

    PubMed

    Romagnoli, Mathilde; Mineva, Nora D; Polmear, Michael; Conrad, Catharina; Srinivasan, Srimathi; Loussouarn, Delphine; Barillé-Nion, Sophie; Georgakoudi, Irene; Dagg, Áine; McDermott, Enda W; Duffy, Michael J; McGowan, Patricia M; Schlomann, Uwe; Parsons, Maddy; Bartsch, Jörg W; Sonenshein, Gail E

    2014-02-01

    The transmembrane metalloprotease-disintegrin ADAM8 mediates cell adhesion and shedding of ligands, receptors and extracellular matrix components. Here, we report that ADAM8 is abundantly expressed in breast tumors and derived metastases compared to normal tissue, especially in triple-negative breast cancers (TNBCs). Furthermore, high ADAM8 levels predicted poor patient outcome. Consistently, ADAM8 promoted an aggressive phenotype of TNBC cells in culture. In a mouse orthotopic model, tumors derived from TNBC cells with ADAM8 knockdown failed to grow beyond a palpable size and displayed poor vascularization. Circulating tumor cells and brain metastases were also significantly reduced. Mechanistically, ADAM8 stimulated both angiogenesis through release of VEGF-A and transendothelial cell migration via β1-integrin activation. In vivo, treatment with an anti-ADAM8 antibody from the time of cell inoculation reduced primary tumor burden and metastases. Furthermore, antibody treatment of established tumors profoundly decreased metastases in a resection model. As a non-essential protein under physiological conditions, ADAM8 represents a promising novel target for treatment of TNBCs, which currently lack targeted therapies and frequently progress with fatal dissemination.

  8. 77 FR 75207 - The Adams Express Company and Petroleum & Resources Corporation; Notice of Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-19

    ... COMMISSION The Adams Express Company and Petroleum & Resources Corporation; Notice of Application December 13... and Petroleum & Resources Corporation (the ``Funds''). DATES: Filing Dates: The application was filed..., 2012, The Adams Express Company held approximately 8.5% of the outstanding shares of...

  9. The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling.

    PubMed

    Weber, Silvio; Niessen, Michaela T; Prox, Johannes; Lüllmann-Rauch, Renate; Schmitz, Annika; Schwanbeck, Ralf; Blobel, Carl P; Jorissen, Ellen; de Strooper, Bart; Niessen, Carien M; Saftig, Paul

    2011-02-01

    The disintegrin and metalloproteinase Adam10 has been implicated in the regulation of key signaling pathways that determine skin morphogenesis and homeostasis. To address the in vivo relevance of Adam10 in the epidermis, we have selectively disrupted Adam10 during skin morphogenesis and in adult skin. K14-Cre driven epidermal Adam10 deletion leads to perinatal lethality, barrier impairment and absence of sebaceous glands. A reduction of spinous layers, not associated with differences in either proliferation or apoptosis, indicates that loss of Adam10 triggers a premature differentiation of spinous keratinocytes. The few surviving K14-Adam10-deleted mice and mice in which Adam10 was deleted postnatally showed loss of hair, malformed vibrissae, epidermal hyperproliferation, cyst formation, thymic atrophy and upregulation of the cytokine thymic stromal lymphopoetin (TSLP), thus indicating non cell-autonomous multi-organ disease resulting from a compromised barrier. Together, these phenotypes closely resemble skin specific Notch pathway loss-of-function phenotypes. Notch processing is indeed strongly reduced resulting in decreased levels of Notch intracellular domain fragment and functional Notch signaling. The data identify Adam10 as the major Site-2 processing enzyme for Notch in the epidermis in vivo, and thus as a central regulator of skin development and maintenance.

  10. Elemental compositions of two extrasolar rocky planetesimals

    SciTech Connect

    Xu, S.; Jura, M.; Klein, B.; Zuckerman, B.; Koester, D. E-mail: jura@astro.ucla.edu E-mail: ben@astro.ucla.edu

    2014-03-10

    We report Keck/HIRES and Hubble Space Telescope/COS spectroscopic studies of extrasolar rocky planetesimals accreted onto two hydrogen atmosphere white dwarfs, G29-38 and GD 133. In G29-38, eight elements are detected, including C, O, Mg, Si, Ca, Ti, Cr, and Fe while in GD 133, O, Si, Ca, and marginally Mg are seen. These two extrasolar planetesimals show a pattern of refractory enhancement and volatile depletion. For G29-38, the observed composition can be best interpreted as a blend of a chondritic object with some refractory-rich material, a result from post-nebular processing. Water is very depleted in the parent body accreted onto G29-38, based on the derived oxygen abundance. The inferred total mass accretion rate in GD 133 is the lowest of all known dusty white dwarfs, possibly due to non-steady state accretion. We continue to find that a variety of extrasolar planetesimals all resemble to zeroth order the elemental composition of bulk Earth.

  11. Planned Parenthood of Rocky Mountains v. Owens.

    PubMed

    2002-01-01

    Court Decision: 287 Federal Reporter, 3d Series 910; 2002 Apr 17 (date of decision). The U.S. Court of Appeals for the Tenth Circuit agreed with a lower court that Colorado's Parental Notification Act (PNA) was unconstitutional because it failed to provide an exception for a minor's health. Planned Parenthood of the Rocky Mountain Services brought an action challenging the constitutionality of the PNA which required parental notice and a waiting period before a minor could obtain an abortion. The PNA granted an exception in cases where a physician reports that the minor is a victim of child abuse or neglect at the hands of the persons entitled to notice and where an immediate abortion is necessary to prevent the minor's imminent death. The Tenth Circuit held that state abortion regulations must provide an exception to protect maternal health. Noting that medical complications could result in significant harm to the the health of a pregnant woman without constituting a threat of imminent death, the court held that the PNA infringed on the ability of any pregnant woman to protect her health because it failed to provide adequate exceptions to parental notice in cases where maternal health was at risk. The court rejected the defendant's argument that Colorado's Children's Code could be read as superseding the PNA and providing a maternal health exception, and held that the PNA superseded other Colorado law.

  12. The Critical Mass Laboratory at Rocky Flats

    SciTech Connect

    Rothe, Robert E

    2003-10-15

    The Critical Mass Laboratory (CML) at Rocky Flats northwest of Denver, Colorado, was built in 1964 and commissioned to conduct nuclear experiments on January 28, 1965. It was built to attain more accurate and precise experimental data to ensure nuclear criticality safety at the plant than were previously possible. Prior to its construction, safety data were obtained from long extrapolations of subcritical data (called in situ experiments), calculated parameters from reactor engineering 'models', and a few other imprecise methods. About 1700 critical and critical-approach experiments involving several chemical forms of enriched uranium and plutonium were performed between then and 1988. These experiments included single units and arrays of fissile materials, reflected and 'bare' systems, and configurations with various degrees of moderation, as well as some containing strong neutron absorbers. In 1989, a raid by the Federal Bureau of Investigation (FBI) caused the plant as a whole to focus on 'resumption' instead of further criticality safety experiments. Though either not recognized or not admitted for a few years, that FBI raid did sound the death knell for the CML. The plant's optimistic goal of resumption evolved to one of deactivation, decommissioning, and plantwide demolition during the 1990s. The once-proud CML facility was finally demolished in April of 2002.

  13. Rocky Mountain spotted fever: a seasonal alert.

    PubMed

    Walker, D H

    1995-05-01

    Rocky Mountain spotted fever occurs during seasonal tick activity. A history of exposure to tick-containing habitats within the 3- to 12-day incubation period is a key epidemiological factor. The signs of fever, headache, myalgia, nausea, vomiting, and anorexia at onset of infection are difficult to distinguish from those of self-limited viral infections. Rash usually appears later and, if present, progresses through a sequence of stages and distribution that are never pathognomonic. The effects of disseminated Rickettsia rickettsii infection of endothelial cells include increased vascular permeability, edema, hypovolemia, hypotension, prerenal azotemia, and, in life-threatening cases, pulmonary edema, shock, acute tubular necrosis, and meningoencephalitis. In severe cases, fluid management is a challenge. The clinical diagnosis, which is difficult, is rarely assisted by laboratory findings because antibodies are usually detected only in convalescence, and immunohistologic methods for detection of rickettsiae are unavailable in most clinics. Doxycycline is the treatment of choice except for pregnant or allergic patients, who are treated with chloramphenicol.

  14. Exploring groundwater processes in Rocky Mountain headwaters

    NASA Astrophysics Data System (ADS)

    Janzen, D.; Ireson, A. M.; Yassin, F. A.

    2014-12-01

    More than one-sixth of the Earth's human population relies on freshwater originating in mountain headwaters, which is understood to be generated largely from snowpacks that melt throughout the spring and summer. Annual hydrographs in these regions are characterized by large peaks occurring in the spring, followed by slow recession towards winter baseflow conditions. However, atmospheric warming trends are found to coincide with earlier periods of snowmelt, leading to increased flows in spring and decreased flows in summer. This decreased ability of our 'water towers' to store snow late into the summer suggests that other mechanisms of storage and release may become more important in sustaining baseflows. In particular, subsurface processes leading to late summer and winter flow will become increasingly important earlier on, but are as yet poorly understood. By utilising historical data to inform a better understanding of late-season subsurface processes, we will be better prepared to predict how these mountains will temporarily store and release groundwater in a warmer climate. Here, we analyse long-term data sets from a small (Marmot Creek, Alberta ~10 km2) and a large (Bow River at Banff, Alberta ~1000 km2) basinwithin the Canadian Rocky Mountains, comparing observations with model outputs, to investigate late-season hydrological responses, and particularly the role of groundwater as a temporary storage mechanism.

  15. The Rocky World of Young Planetary Systems

    NASA Technical Reports Server (NTRS)

    2004-01-01

    [figure removed for brevity, see original site] Figure 1 [figure removed for brevity, see original site] [figure removed for brevity, see original site] Panel A of Inset Panel B of Inset Panel C of Inset

    This artist's concept illustrates how planetary systems arise out of massive collisions between rocky bodies. New findings from NASA's Spitzer Space Telescope show that these catastrophes continue to occur around stars even after they have developed full-sized planets, when they are as old as one hundred million years. For reference, our own Sun, at 4.5 billion years old, is far past this late stage of planet formation.

    In this image, a young star is shown circled by full-sized planets, and rings of dust beyond. These rings, also called 'debris discs,' arise when embryonic planets smash into each other. One of these collisions is illustrated in the inset of Figure 1.

    Spitzer was able to see the dust generated by these collisions with its powerful infrared vision.

  16. Effective discharge in Rocky Mountain headwater streams

    NASA Astrophysics Data System (ADS)

    Bunte, Kristin; Abt, Steven R.; Swingle, Kurt W.; Cenderelli, Dan A.

    2014-11-01

    Whereas effective discharge (Qeff) in mountain streams is commonly associated with a moderate flow such as bankfull discharge (Qbf), this study found that the maximum discharge (Qmax), and not bankfull discharge, is the channel forming or effective flow for gravel transport in plane-bed streams where partial bed mobility causes steep gravel transport rating curves. Qeff may approach bankfull flow in some step-pool channels where gravel moves over a static cobble/boulder bed. Our conclusions are based on magnitude-frequency analyses conducted at 41 gauged Rocky Mountain headwater streams. Because these gauged streams lacked gravel transport data, as is typical, comparable streams with measured transport rates were used to develop scaling relations for rating curve exponents with stream and watershed characteristics. Those scaling relations were then used to estimate the steepness of gravel rating curves at the 41 gauged but unsampled sites. The measured flow frequency distributions were characterized by two fitted power functions. The steepness of the flow frequency distributions and the estimated steepness of gravel transport relations were combined in magnitude-frequency analyses to compute Qeff.

  17. ADAM-17 regulates endothelial cell morphology, proliferation, and in vitro angiogenesis

    SciTech Connect

    Goeoz, Pal Goeoz, Monika; Baldys, Aleksander; Hoffman, Stanley

    2009-02-27

    Modulation of angiogenesis is a promising approach for treating a wide variety of human diseases including ischemic heart disease and cancer. In this study, we show that ADAM-17 is an important regulator of several key steps during angiogenesis. Knocking down ADAM-17 expression using lentivirus-delivered siRNA in HUVECs inhibited cell proliferation and the ability of cells to form close contact in two-dimensional cultures. Similarly, ADAM-17 depletion inhibited the ability of HUVECs to form capillary-like networks on top of three-dimensional Matrigel as well as in co-culture with fibroblasts within a three-dimensional scaffold. In mechanistic studies, both baseline and VEGF-induced MMP-2 activation and Matrigel invasion were inhibited by ADAM-17 depletion. Based on our findings we propose that ADAM-17 is part of a novel pro-angiogenic pathway leading to MMP-2 activation and vessel formation.

  18. The role of CXCL16 and its processing metalloproteinases ADAM10 and ADAM17 in the proliferation and migration of human mesangial cells

    SciTech Connect

    Schramme, Anja; Abdel-Bakky, Mohamed Sadek; Kaempfer-Kolb, Nicole; Pfeilschifter, Josef

    2008-05-30

    In this study, we analyzed the regulation and functional role of CXCL16 in human mesangial cells (hMCs). We can show, that CXCL16 is constitutively expressed in hMCs and is further up-regulated by cytokine mix (IFN{gamma}, TNF{alpha}, and IL1{beta}). The constitutive release of CXCL16 from hMCs was rapidly induced by the stimulation with cytokines. We identified ADAM10 and ADAM17 as being responsible for the cytokine-induced shedding of CXCL16. Notably, targeting ADAM10 and ADAM17 in hMCs decreased the chemotaxis of T-Jurkat cells, whereas the inhibition of CXCL16 had no significant influence. This suggests that both proteases are important players in the recruitment of immune cells into the glomerulus, but other substrates than CXCL16 are involved in this process. Finally, we could show that the inhibition of CXCL16, ADAM10, and ADAM17 led to a strong reduction of cell proliferation and migration of hMCs. This finding could be important to develop novel diagnostic and therapeutic strategies to treat mesangial proliferative kidney diseases.

  19. TLR4-mediated galectin-1 production triggers epithelial-mesenchymal transition in colon cancer cells through ADAM10- and ADAM17-associated lactate production.

    PubMed

    Park, Ga Bin; Kim, Daejin

    2017-01-01

    Toll-like receptor 4 (TLR4) activation is a key contributor to the carcinogenesis of colon cancer. Overexpression of galectin-1 (Gal-1) also correlates with increased invasive activity of colorectal cancer. Lactate production is a critical predictive factor of risk of metastasis, but the functional relationship between intracellular lactate and Gal-1 expression in TLR4-activated colon cancer remains unknown. In this study, we investigated the underlying mechanism and role of Gal-1 in metastasis and invasion of colorectal cancer (CRC) cells after TLR4 stimulation. Exposure to the TLR4 ligand lipopolysaccharide (LPS) increased expression of Gal-1, induced EMT-related cytokines, triggered the activation of glycolysis-related enzymes, and promoted lactate production. Gene silencing of TLR4 and Gal-1 in CRC cells inhibited lactate-mediated epithelial-mesenchymal transition (EMT) after TLR4 stimulation. Gal-1-mediated activation of a disintegrin and metalloproteinase 10 (ADAM10) and ADAM 17 increased the invasion activity and expression of mesenchymal characteristics in LPS-activated CRC cells. Conversely, inhibition of ADAM10 or ADAM17 effectively blocked the generation of lactate and the migration capacity of LPS-treated CRC cells. Thus, the TLR4/Gal-1 signaling pathway regulates lactate-mediated EMT processes through the activation of ADAM10 and ADAM17 in CRC cells.

  20. Functional analysis of a breast cancer-associated mutation in the intracellular domain of the metalloprotease ADAM12.

    PubMed

    Stautz, Dorte; Wewer, Ulla M; Kveiborg, Marie

    2012-01-01

    A recently identified breast cancer-associated mutation in the metalloprotease ADAM12 alters a potential dileucine trafficking signal, which could affect protein processing and cellular localization. ADAM12 belongs to the group of A Disintegrin And Metalloproteases (ADAMs), which are typically membrane-associated proteins involved in ectodomain shedding, cell-adhesion, and signaling. ADAM12 as well as several members of the ADAM family are over-expressed in various cancers, correlating with disease stage. Three breast cancer-associated somatic mutations were previously identified in ADAM12, and two of these, one in the metalloprotease domain and another in the disintegrin domain, were investigated and found to result in protein misfolding, retention in the secretory pathway, and failure of zymogen maturation. The third mutation, p.L792F in the ADAM12 cytoplasmic tail, was not investigated, but is potentially significant given its location within a di-leucine motif, which is recognized as a potential cellular trafficking signal. The present study was motivated both by the potential relevance of this documented mutation to cancer, as well as for determining the role of the di-leucine motif in ADAM12 trafficking. Expression of ADAM12 p.L792F in mammalian cells demonstrated quantitatively similar expression levels and zymogen maturation as wild-type (WT) ADAM12, as well as comparable cellular localizations. A cell surface biotinylation assay demonstrated that cell surface levels of ADAM12 WT and ADAM12 p.L792F were similar and that internalization of the mutant occurred at the same rate and extent as for ADAM12 WT. Moreover, functional analysis revealed no differences in cell proliferation or ectodomain shedding of epidermal growth factor (EGF), a known ADAM12 substrate between WT and mutant ADAM12. These data suggest that the ADAM12 p.L792F mutation is unlikely to be a driver (cancer causing)-mutation in breast cancer.

  1. 8. Photocopy of photograph, U.S. Army, ca. 1943 (original print ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Photocopy of photograph, U.S. Army, ca. 1943 (original print located at Rocky Mountain Arsenal, Commerce City, Colorado). R.M.A. - 313 - CONTROL LABORATORY LOOKING N.E. - Rocky Mountain Arsenal, Laboratory Building, 510 feet South of December Seventh Avenue; 175 feet East of D Street, Commerce City, Adams County, CO

  2. 221. Photocopy of photograph, Denver Post photographer, 20 March 1970 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    221. Photocopy of photograph, Denver Post photographer, 20 March 1970 (original print located at Rocky Mountain Arsenal, Commerce City, Colorado). RABBIT USED TO TEST FOR NERVE GAS AT RMA. - Rocky Mountain Arsenal, Bounded by Ninety-sixth Avenue & Fifty-sixth Avenue, Buckley Road, Quebec Street & Colorado Highway 2, Commerce City, Adams County, CO

  3. 3. Photocopy of photograph, U.S. Army, ca. 1943 (original print ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Photocopy of photograph, U.S. Army, ca. 1943 (original print located at Rocky Mountain Arsenal, Commerce City, Colorado). R.M.A. 624 MACHINE SHOP LOOKING S.EAST. - Rocky Mountain Arsenal, Machine Shop, 1140 feet North of Sixth Avenue; 430 feet West of B Street, Commerce City, Adams County, CO

  4. Photocopy of photograph, U.S. Army, ca. 1943 (original print located ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of photograph, U.S. Army, ca. 1943 (original print located at Rocky Mountain Arsenal, Commerce City, Colorado). R.M.A. 624 MACHINE SHOP LOOKING N.W. - Rocky Mountain Arsenal, Machine Shop, 1140 feet North of Sixth Avenue; 430 feet West of B Street, Commerce City, Adams County, CO

  5. 207. Photocopy of photograph, Denver Post photographer, 22 March 1954 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    207. Photocopy of photograph, Denver Post photographer, 22 March 1954 (original print located at Rocky Mountain Arsenal, Commerce City, Colorado). MUSTARD GAS ASSEMBLY LINE, WHERE ARSENAL EMPLOYEES FILL 105mm ARTILLERY SHELL CASINGS WITH DEADLY GAS. - Rocky Mountain Arsenal, Bounded by Ninety-sixth Avenue & Fifty-sixth Avenue, Buckley Road, Quebec Street & Colorado Highway 2, Commerce City, Adams County, CO

  6. 217. Photocopy of photograph, U.S. Army, ca. 1970 (original print ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    217. Photocopy of photograph, U.S. Army, ca. 1970 (original print located at Rocky Mountain Arsenal, Commerce City, Colorado). DEMIL LINE IN BUILDING 1601. - Rocky Mountain Arsenal, Bounded by Ninety-sixth Avenue & Fifty-sixth Avenue, Buckley Road, Quebec Street & Colorado Highway 2, Commerce City, Adams County, CO

  7. 219. Photocopy of photograph, U.S. Army, ca. 1970 (original print ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    219. Photocopy of photograph, U.S. Army, ca. 1970 (original print located at Rocky Mountain Arsenal, Commerce City, Colorado). TWO WORKERS ON DEMIL LINE IN BUILDING 1601. - Rocky Mountain Arsenal, Bounded by Ninety-sixth Avenue & Fifty-sixth Avenue, Buckley Road, Quebec Street & Colorado Highway 2, Commerce City, Adams County, CO

  8. 216. Photocopy of photograph, U.S. Army, ca. 1970 (original print ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    216. Photocopy of photograph, U.S. Army, ca. 1970 (original print located at Rocky Mountain Arsenal, Commerce City, Colorado). WORKER AT DEMIL LINE IN BUILDING 1601. - Rocky Mountain Arsenal, Bounded by Ninety-sixth Avenue & Fifty-sixth Avenue, Buckley Road, Quebec Street & Colorado Highway 2, Commerce City, Adams County, CO

  9. 218. Photocopy of photograph, U.S. Army, ca. 1970 (original print ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    218. Photocopy of photograph, U.S. Army, ca. 1970 (original print located at Rocky Mountain Arsenal, Commerce City, Colorado). DETAIL OF DEMIL LINE IN BUILDING 1601. - Rocky Mountain Arsenal, Bounded by Ninety-sixth Avenue & Fifty-sixth Avenue, Buckley Road, Quebec Street & Colorado Highway 2, Commerce City, Adams County, CO

  10. 176. Photocopy of photograph, U.S. Army, ca. 1943 (original print ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    176. Photocopy of photograph, U.S. Army, ca. 1943 (original print located at Rocky Mountain Arsenal, Commerce City, Colorado). R.M.A. - 626 - POST ENGINEER LOOKING NORTH MACHINE & WELDING SHOP. - Rocky Mountain Arsenal, Bounded by Ninety-sixth Avenue & Fifty-sixth Avenue, Buckley Road, Quebec Street & Colorado Highway 2, Commerce City, Adams County, CO

  11. 200. Photocopy of photograph, U.S. Army, ca. 1955 (original print ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    200. Photocopy of photograph, U.S. Army, ca. 1955 (original print located at Rocky Mountain Arsenal, Commerce City, Colorado). ARSENAL PLANT AREA CHEMIST. - Rocky Mountain Arsenal, Bounded by Ninety-sixth Avenue & Fifty-sixth Avenue, Buckley Road, Quebec Street & Colorado Highway 2, Commerce City, Adams County, CO

  12. 3. Photocopy of photograph, U.S. Army, ca. 1943 (original print ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Photocopy of photograph, U.S. Army, ca. 1943 (original print located at Rocky Mountain Arsenal, Commerce City, Colorado). R.M.A. - 613 - FIRE HOUSE LOOKING N.E. - Rocky Mountain Arsenal, Fire House, 960 feet North of Sixth Avenue; 90 feet West of B Street, Commerce City, Adams County, CO

  13. 4. Photocopy of photograph, U.S. Army, ca. 1943 (original print ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Photocopy of photograph, U.S. Army, ca. 1943 (original print located at Rocky Mountain Arsenal, Commerce City, Colorado). R.M.A. - 613 - FIRE HOUSE 2nd FL. LOOKING N.E. - Rocky Mountain Arsenal, Fire House, 960 feet North of Sixth Avenue; 90 feet West of B Street, Commerce City, Adams County, CO

  14. 2. Photocopy of photograph, U.S. Army, ca. 1943 (original print ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Photocopy of photograph, U.S. Army, ca. 1943 (original print located at Rocky Mountain Arsenal, Commerce City, Colorado). R.M.A. - 613 - FIRE HOUSE LOOKING N.W. - Rocky Mountain Arsenal, Fire House, 960 feet North of Sixth Avenue; 90 feet West of B Street, Commerce City, Adams County, CO

  15. Photocopy of photograph, U.S. Army, ca. 1943 (original print located ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of photograph, U.S. Army, ca. 1943 (original print located at Rocky Mountain Arsenal, Commerce City, Colorado). R.M.A. -523-A.T. (ARSENIC TRICHLORIDE) MFG. LOOKING N.EAST - Rocky Mountain Arsenal, Arsenic Trioxide Dry Storage Silo, December Seventh Avenue & D Street, Commerce City, Adams County, CO

  16. 2. Photocopy of photograph, U.S. Army, ca. 1943 (original print ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Photocopy of photograph, U.S. Army, ca. 1943 (original print located at Rocky Mountain Arsenal, Commerce City, Colorado). R.M.A. - 112 - COMMUNICATION BLDG. - Rocky Mountain Arsenal, Communication Building, 75 feet North of December Seventh Avenue; 2400 feet East of C Street, Commerce City, Adams County, CO

  17. 202. Photocopy of photograph, Denver Post photographer, 2 August 1951 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    202. Photocopy of photograph, Denver Post photographer, 2 August 1951 (original print located at Rocky Mountain Arsenal, Commerce City, Colorado). NAPALM BOMB ASSEMBLY LINE. - Rocky Mountain Arsenal, Bounded by Ninety-sixth Avenue & Fifty-sixth Avenue, Buckley Road, Quebec Street & Colorado Highway 2, Commerce City, Adams County, CO

  18. 3. Photocopy of photograph, U.S. Army, ca. 1943 (original print ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Photocopy of photograph, U.S. Army, ca. 1943 (original print located at Rocky Mountain Arsenal, Commerce City, Colorado). R.M.A. - 112 - COMMUNICATION BLDG. SOUTH END SWITCH BOARD ROOM. - Rocky Mountain Arsenal, Communication Building, 75 feet North of December Seventh Avenue; 2400 feet East of C Street, Commerce City, Adams County, CO

  19. 10. Photocopy of photograph, U.S. Army, ca. 1943 (original print ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. Photocopy of photograph, U.S. Army, ca. 1943 (original print located at Rocky Mountain Arsenal, Commerce City, Colorado). R.M.A. - 321 - BOILER HOUSE 1st FL. - LOOKING EAST. - Rocky Mountain Arsenal, Boiler Plant-Central Gas Heat Plant, 1022 feet South of December Seventh Avenue; 525 feet West of D Street, Commerce City, Adams County, CO

  20. 13. Photocopy of photograph, U.S. Army, ca. 1943 (original print ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. Photocopy of photograph, U.S. Army, ca. 1943 (original print located at Rocky Mountain Arsenal, Commerce City, Colorado). R.M.A. - 321 - BOILER HOUSE 3rd FL. LOOKING WEST. - Rocky Mountain Arsenal, Boiler Plant-Central Gas Heat Plant, 1022 feet South of December Seventh Avenue; 525 feet West of D Street, Commerce City, Adams County, CO