Science.gov

Sample records for adaptive critic designs

  1. Adaptive and Adaptable Automation Design: A Critical Review of the Literature and Recommendations for Future Research

    NASA Technical Reports Server (NTRS)

    Prinzel, Lawrence J., III; Kaber, David B.

    2006-01-01

    This report presents a review of literature on approaches to adaptive and adaptable task/function allocation and adaptive interface technologies for effective human management of complex systems that are likely to be issues for the Next Generation Air Transportation System, and a focus of research under the Aviation Safety Program, Integrated Intelligent Flight Deck Project. Contemporary literature retrieved from an online database search is summarized and integrated. The major topics include the effects of delegation-type, adaptable automation on human performance, workload and situation awareness, the effectiveness of various automation invocation philosophies and strategies to function allocation in adaptive systems, and the role of user modeling in adaptive interface design and the performance implications of adaptive interface technology.

  2. Adaptive critic autopilot design of bank-to-turn missiles using fuzzy basis function networks.

    PubMed

    Lin, Chuan-Kai

    2005-04-01

    A new adaptive critic autopilot design for bank-to-turn missiles is presented. In this paper, the architecture of adaptive critic learning scheme contains a fuzzy-basis-function-network based associative search element (ASE), which is employed to approximate nonlinear and complex functions of bank-to-turn missiles, and an adaptive critic element (ACE) generating the reinforcement signal to tune the associative search element. In the design of the adaptive critic autopilot, the control law receives signals from a fixed gain controller, an ASE and an adaptive robust element, which can eliminate approximation errors and disturbances. Traditional adaptive critic reinforcement learning is the problem faced by an agent that must learn behavior through trial-and-error interactions with a dynamic environment, however, the proposed tuning algorithm can significantly shorten the learning time by online tuning all parameters of fuzzy basis functions and weights of ASE and ACE. Moreover, the weight updating law derived from the Lyapunov stability theory is capable of guaranteeing both tracking performance and stability. Computer simulation results confirm the effectiveness of the proposed adaptive critic autopilot.

  3. Adaptive critics for dynamic optimization.

    PubMed

    Kulkarni, Raghavendra V; Venayagamoorthy, Ganesh Kumar

    2010-06-01

    A novel action-dependent adaptive critic design (ACD) is developed for dynamic optimization. The proposed combination of a particle swarm optimization-based actor and a neural network critic is demonstrated through dynamic sleep scheduling of wireless sensor motes for wildlife monitoring. The objective of the sleep scheduler is to dynamically adapt the sleep duration to node's battery capacity and movement pattern of animals in its environment in order to obtain snapshots of the animal on its trajectory uniformly. Simulation results show that the sleep time of the node determined by the actor critic yields superior quality of sensory data acquisition and enhanced node longevity. PMID:20223635

  4. Continuous-time adaptive critics.

    PubMed

    Hanselmann, Thomas; Noakes, Lyle; Zaknich, Anthony

    2007-05-01

    A continuous-time formulation of an adaptive critic design (ACD) is investigated. Connections to the discrete case are made, where backpropagation through time (BPTT) and real-time recurrent learning (RTRL) are prevalent. Practical benefits are that this framework fits in well with plant descriptions given by differential equations and that any standard integration routine with adaptive step-size does an adaptive sampling for free. A second-order actor adaptation using Newton's method is established for fast actor convergence for a general plant and critic. Also, a fast critic update for concurrent actor-critic training is introduced to immediately apply necessary adjustments of critic parameters induced by actor updates to keep the Bellman optimality correct to first-order approximation after actor changes. Thus, critic and actor updates may be performed at the same time until some substantial error build up in the Bellman optimality or temporal difference equation, when a traditional critic training needs to be performed and then another interval of concurrent actor-critic training may resume. PMID:17526332

  5. Adaptive Actor-Critic Design-Based Integral Sliding-Mode Control for Partially Unknown Nonlinear Systems With Input Disturbances.

    PubMed

    Fan, Quan-Yong; Yang, Guang-Hong

    2016-01-01

    This paper is concerned with the problem of integral sliding-mode control for a class of nonlinear systems with input disturbances and unknown nonlinear terms through the adaptive actor-critic (AC) control method. The main objective is to design a sliding-mode control methodology based on the adaptive dynamic programming (ADP) method, so that the closed-loop system with time-varying disturbances is stable and the nearly optimal performance of the sliding-mode dynamics can be guaranteed. In the first step, a neural network (NN)-based observer and a disturbance observer are designed to approximate the unknown nonlinear terms and estimate the input disturbances, respectively. Based on the NN approximations and disturbance estimations, the discontinuous part of the sliding-mode control is constructed to eliminate the effect of the disturbances and attain the expected equivalent sliding-mode dynamics. Then, the ADP method with AC structure is presented to learn the optimal control for the sliding-mode dynamics online. Reconstructed tuning laws are developed to guarantee the stability of the sliding-mode dynamics and the convergence of the weights of critic and actor NNs. Finally, the simulation results are presented to illustrate the effectiveness of the proposed method.

  6. Adaptive Actor-Critic Design-Based Integral Sliding-Mode Control for Partially Unknown Nonlinear Systems With Input Disturbances.

    PubMed

    Fan, Quan-Yong; Yang, Guang-Hong

    2016-01-01

    This paper is concerned with the problem of integral sliding-mode control for a class of nonlinear systems with input disturbances and unknown nonlinear terms through the adaptive actor-critic (AC) control method. The main objective is to design a sliding-mode control methodology based on the adaptive dynamic programming (ADP) method, so that the closed-loop system with time-varying disturbances is stable and the nearly optimal performance of the sliding-mode dynamics can be guaranteed. In the first step, a neural network (NN)-based observer and a disturbance observer are designed to approximate the unknown nonlinear terms and estimate the input disturbances, respectively. Based on the NN approximations and disturbance estimations, the discontinuous part of the sliding-mode control is constructed to eliminate the effect of the disturbances and attain the expected equivalent sliding-mode dynamics. Then, the ADP method with AC structure is presented to learn the optimal control for the sliding-mode dynamics online. Reconstructed tuning laws are developed to guarantee the stability of the sliding-mode dynamics and the convergence of the weights of critic and actor NNs. Finally, the simulation results are presented to illustrate the effectiveness of the proposed method. PMID:26357411

  7. Adaptive critic designs for discrete-time zero-sum games with application to H(infinity) control.

    PubMed

    Al-Tamimi, Asma; Abu-Khalaf, Murad; Lewis, Frank L

    2007-02-01

    In this correspondence, adaptive critic approximate dynamic programming designs are derived to solve the discrete-time zero-sum game in which the state and action spaces are continuous. This results in a forward-in-time reinforcement learning algorithm that converges to the Nash equilibrium of the corresponding zero-sum game. The results in this correspondence can be thought of as a way to solve the Riccati equation of the well-known discrete-time H(infinity) optimal control problem forward in time. Two schemes are presented, namely: 1) a heuristic dynamic programming and 2) a dual-heuristic dynamic programming, to solve for the value function and the costate of the game, respectively. An H(infinity) autopilot design for an F-16 aircraft is presented to illustrate the results.

  8. Adaptive critic designs for discrete-time zero-sum games with application to H(infinity) control.

    PubMed

    Al-Tamimi, Asma; Abu-Khalaf, Murad; Lewis, Frank L

    2007-02-01

    In this correspondence, adaptive critic approximate dynamic programming designs are derived to solve the discrete-time zero-sum game in which the state and action spaces are continuous. This results in a forward-in-time reinforcement learning algorithm that converges to the Nash equilibrium of the corresponding zero-sum game. The results in this correspondence can be thought of as a way to solve the Riccati equation of the well-known discrete-time H(infinity) optimal control problem forward in time. Two schemes are presented, namely: 1) a heuristic dynamic programming and 2) a dual-heuristic dynamic programming, to solve for the value function and the costate of the game, respectively. An H(infinity) autopilot design for an F-16 aircraft is presented to illustrate the results. PMID:17278575

  9. Criticality of Adaptive Control Dynamics

    NASA Astrophysics Data System (ADS)

    Patzelt, Felix; Pawelzik, Klaus

    2011-12-01

    We show, that stabilization of a dynamical system can annihilate observable information about its structure. This mechanism induces critical points as attractors in locally adaptive control. It also reveals, that previously reported criticality in simple controllers is caused by adaptation and not by other controller details. We apply these results to a real-system example: human balancing behavior. A model of predictive adaptive closed-loop control subject to some realistic constraints is introduced and shown to reproduce experimental observations in unprecedented detail. Our results suggests, that observed error distributions in between the Lévy and Gaussian regimes may reflect a nearly optimal compromise between the elimination of random local trends and rare large errors.

  10. Integrated control of wind farms, FACTS devices and the power network using neural networks and adaptive critic designs

    NASA Astrophysics Data System (ADS)

    Qiao, Wei

    Worldwide concern about the environmental problems and a possible energy crisis has led to increasing interest in clean and renewable energy generation. Among various renewable energy sources, wind power is the most rapidly growing one. Therefore, how to provide efficient, reliable, and high-performance wind power generation and distribution has become an important and practical issue in the power industry. In addition, because of the new constraints placed by the environmental and economical factors, the trend of power system planning and operation is toward maximum utilization of the existing infrastructure with tight system operating and stability margins. This trend, together with the increased penetration of renewable energy sources, will bring new challenges to power system operation, control, stability and reliability which require innovative solutions. Flexible ac transmission system (FACTS) devices, through their fast, flexible, and effective control capability, provide one possible solution to these challenges. To fully utilize the capability of individual power system components, e.g., wind turbine generators (WTGs) and FACTS devices, their control systems must be suitably designed with high reliability. Moreover, in order to optimize local as well as system-wide performance and stability of the power system, real-time local and wide-area coordinated control is becoming an important issue. Power systems containing conventional synchronous generators, WTGs, and FACTS devices are large-scale, nonlinear, nonstationary, stochastic and complex systems distributed over large geographic areas. Traditional mathematical tools and system control techniques have limitations to control such complex systems to achieve an optimal performance. Intelligent and bio-inspired techniques, such as swarm intelligence, neural networks, and adaptive critic designs, are emerging as promising alternative technologies for power system control and performance optimization. This

  11. Adaptation as organism design

    PubMed Central

    Gardner, Andy

    2009-01-01

    The problem of adaptation is to explain the apparent design of organisms. Darwin solved this problem with the theory of natural selection. However, population geneticists, whose responsibility it is to formalize evolutionary theory, have long neglected the link between natural selection and organismal design. Here, I review the major historical developments in theory of organismal adaptation, clarifying what adaptation is and what it is not, and I point out future avenues for research. PMID:19793739

  12. Adaptive Sampling Designs.

    ERIC Educational Resources Information Center

    Flournoy, Nancy

    Designs for sequential sampling procedures that adapt to cumulative information are discussed. A familiar illustration is the play-the-winner rule in which there are two treatments; after a random start, the same treatment is continued as long as each successive subject registers a success. When a failure occurs, the other treatment is used until…

  13. Design of Critical Components

    NASA Technical Reports Server (NTRS)

    Hendricks, Robert C.; Zaretsky, Erwin V.

    2001-01-01

    Critical component design is based on minimizing product failures that results in loss of life. Potential catastrophic failures are reduced to secondary failures where components removed for cause or operating time in the system. Issues of liability and cost of component removal become of paramount importance. Deterministic design with factors of safety and probabilistic design address but lack the essential characteristics for the design of critical components. In deterministic design and fabrication there are heuristic rules and safety factors developed over time for large sets of structural/material components. These factors did not come without cost. Many designs failed and many rules (codes) have standing committees to oversee their proper usage and enforcement. In probabilistic design, not only are failures a given, the failures are calculated; an element of risk is assumed based on empirical failure data for large classes of component operations. Failure of a class of components can be predicted, yet one can not predict when a specific component will fail. The analogy is to the life insurance industry where very careful statistics are book-kept on classes of individuals. For a specific class, life span can be predicted within statistical limits, yet life-span of a specific element of that class can not be predicted.

  14. An Adaptive Critic Approach to Reference Model Adaptation

    NASA Technical Reports Server (NTRS)

    Krishnakumar, K.; Limes, G.; Gundy-Burlet, K.; Bryant, D.

    2003-01-01

    Neural networks have been successfully used for implementing control architectures for different applications. In this work, we examine a neural network augmented adaptive critic as a Level 2 intelligent controller for a C- 17 aircraft. This intelligent control architecture utilizes an adaptive critic to tune the parameters of a reference model, which is then used to define the angular rate command for a Level 1 intelligent controller. The present architecture is implemented on a high-fidelity non-linear model of a C-17 aircraft. The goal of this research is to improve the performance of the C-17 under degraded conditions such as control failures and battle damage. Pilot ratings using a motion based simulation facility are included in this paper. The benefits of using an adaptive critic are documented using time response comparisons for severe damage situations.

  15. Criticality and Adaptivity in Enzymatic Networks.

    PubMed

    Steiner, Paul J; Williams, Ruth J; Hasty, Jeff; Tsimring, Lev S

    2016-09-01

    The contrast between the stochasticity of biochemical networks and the regularity of cellular behavior suggests that biological networks generate robust behavior from noisy constituents. Identifying the mechanisms that confer this ability on biological networks is essential to understanding cells. Here we show that queueing for a limited shared resource in broad classes of enzymatic networks in certain conditions leads to a critical state characterized by strong and long-ranged correlations between molecular species. An enzymatic network reaches this critical state when the input flux of its substrate is balanced by the maximum processing capacity of the network. We then consider enzymatic networks with adaptation, when the limiting resource (enzyme or cofactor) is produced in proportion to the demand for it. We show that the critical state becomes an attractor for these networks, which points toward the onset of self-organized criticality. We suggest that the adaptive queueing motif that leads to significant correlations between multiple species may be widespread in biological systems. PMID:27602735

  16. Criticality and Adaptivity in Enzymatic Networks.

    PubMed

    Steiner, Paul J; Williams, Ruth J; Hasty, Jeff; Tsimring, Lev S

    2016-09-01

    The contrast between the stochasticity of biochemical networks and the regularity of cellular behavior suggests that biological networks generate robust behavior from noisy constituents. Identifying the mechanisms that confer this ability on biological networks is essential to understanding cells. Here we show that queueing for a limited shared resource in broad classes of enzymatic networks in certain conditions leads to a critical state characterized by strong and long-ranged correlations between molecular species. An enzymatic network reaches this critical state when the input flux of its substrate is balanced by the maximum processing capacity of the network. We then consider enzymatic networks with adaptation, when the limiting resource (enzyme or cofactor) is produced in proportion to the demand for it. We show that the critical state becomes an attractor for these networks, which points toward the onset of self-organized criticality. We suggest that the adaptive queueing motif that leads to significant correlations between multiple species may be widespread in biological systems.

  17. HELIOS Critical Design Review: Reliability

    NASA Technical Reports Server (NTRS)

    Benoehr, H. C.; Herholz, J.; Prem, H.; Mann, D.; Reichert, L.; Rupp, W.; Campbell, D.; Boettger, H.; Zerwes, G.; Kurvin, C.

    1972-01-01

    This paper presents Helios Critical Design Review Reliability form October 16-20, 1972. The topics include: 1) Reliability Requirement; 2) Reliability Apportionment; 3) Failure Rates; 4) Reliability Assessment; 5) Reliability Block Diagram; and 5) Reliability Information Sheet.

  18. Critical Thinking, Developmental Learning, and Adaptive Flexibility in Organizational Leaders.

    ERIC Educational Resources Information Center

    Duchesne, Robert E., Jr.

    A study examined how developmental learning and adaptive flexibility relate to critical thinking though a survey of 119 organizational leaders (of 341) who had attended a 5-day Leadership Development Program. A questionnaire adapted from the Center for Creative Leadership's Job Challenge Profile measured developmental learning, the Adaptive Style…

  19. Adaptive clinical trial designs in oncology

    PubMed Central

    Zang, Yong; Lee, J. Jack

    2015-01-01

    Adaptive designs have become popular in clinical trial and drug development. Unlike traditional trial designs, adaptive designs use accumulating data to modify the ongoing trial without undermining the integrity and validity of the trial. As a result, adaptive designs provide a flexible and effective way to conduct clinical trials. The designs have potential advantages of improving the study power, reducing sample size and total cost, treating more patients with more effective treatments, identifying efficacious drugs for specific subgroups of patients based on their biomarker profiles, and shortening the time for drug development. In this article, we review adaptive designs commonly used in clinical trials and investigate several aspects of the designs, including the dose-finding scheme, interim analysis, adaptive randomization, biomarker-guided randomization, and seamless designs. For illustration, we provide examples of real trials conducted with adaptive designs. We also discuss practical issues from the perspective of using adaptive designs in oncology trials. PMID:25811018

  20. Critical Studies in Art and Design Education.

    ERIC Educational Resources Information Center

    Thistlewood, David, Ed.

    This book brings together British and U.S. contributions to the debate of a critical studies approach to art and design education. The approach links practice and appreciation. But critical differences exist in definitions of the term design, with the U.S. recognition of design as the use of principles and elements of art in works and a British…

  1. Designing for Productive Adaptations of Curriculum Interventions

    ERIC Educational Resources Information Center

    Debarger, Angela Haydel; Choppin, Jeffrey; Beauvineau, Yves; Moorthy, Savitha

    2013-01-01

    Productive adaptations at the classroom level are evidence-based curriculum adaptations that are responsive to the demands of a particular classroom context and still consistent with the core design principles and intentions of a curriculum intervention. The model of design-based implementation research (DBIR) offers insights into complexities and…

  2. Toward Superconducting Critical Current by Design.

    PubMed

    Sadovskyy, Ivan A; Jia, Ying; Leroux, Maxime; Kwon, Jihwan; Hu, Hefei; Fang, Lei; Chaparro, Carlos; Zhu, Shaofei; Welp, Ulrich; Zuo, Jian-Min; Zhang, Yifei; Nakasaki, Ryusuke; Selvamanickam, Venkat; Crabtree, George W; Koshelev, Alexei E; Glatz, Andreas; Kwok, Wai-Kwong

    2016-06-01

    A new critical-current-by-design paradigm is presented. It aims at predicting the optimal defect landscape in superconductors for targeted applications by elucidating the vortex dynamics responsible for the bulk critical current. To this end, critical current measurements on commercial high-temperature superconductors are combined with large-scale time-dependent Ginzburg-Landau simulations of vortex dynamics.

  3. Drought Adaptation Mechanisms Should Guide Experimental Design.

    PubMed

    Gilbert, Matthew E; Medina, Viviana

    2016-08-01

    The mechanism, or hypothesis, of how a plant might be adapted to drought should strongly influence experimental design. For instance, an experiment testing for water conservation should be distinct from a damage-tolerance evaluation. We define here four new, general mechanisms for plant adaptation to drought such that experiments can be more easily designed based upon the definitions. A series of experimental methods are suggested together with appropriate physiological measurements related to the drought adaptation mechanisms. The suggestion is made that the experimental manipulation should match the rate, length, and severity of soil water deficit (SWD) necessary to test the hypothesized type of drought adaptation mechanism. PMID:27090148

  4. Beyond adaptive-critic creative learning for intelligent mobile robots

    NASA Astrophysics Data System (ADS)

    Liao, Xiaoqun; Cao, Ming; Hall, Ernest L.

    2001-10-01

    Intelligent industrial and mobile robots may be considered proven technology in structured environments. Teach programming and supervised learning methods permit solutions to a variety of applications. However, we believe that to extend the operation of these machines to more unstructured environments requires a new learning method. Both unsupervised learning and reinforcement learning are potential candidates for these new tasks. The adaptive critic method has been shown to provide useful approximations or even optimal control policies to non-linear systems. The purpose of this paper is to explore the use of new learning methods that goes beyond the adaptive critic method for unstructured environments. The adaptive critic is a form of reinforcement learning. A critic element provides only high level grading corrections to a cognition module that controls the action module. In the proposed system the critic's grades are modeled and forecasted, so that an anticipated set of sub-grades are available to the cognition model. The forecasting grades are interpolated and are available on the time scale needed by the action model. The success of the system is highly dependent on the accuracy of the forecasted grades and adaptability of the action module. Examples from the guidance of a mobile robot are provided to illustrate the method for simple line following and for the more complex navigation and control in an unstructured environment. The theory presented that is beyond the adaptive critic may be called creative theory. Creative theory is a form of learning that models the highest level of human learning - imagination. The application of the creative theory appears to not only be to mobile robots but also to many other forms of human endeavor such as educational learning and business forecasting. Reinforcement learning such as the adaptive critic may be applied to known problems to aid in the discovery of their solutions. The significance of creative theory is that it

  5. Adaptation tunes cortical dynamics to a critical regime during vision

    NASA Astrophysics Data System (ADS)

    Shew, Woodrow; Clawson, Wesley; Pobst, Jeff; Karimipanah, Yahya; Wright, Nathaniel; Wessel, Ralf; Shew Lab Team; Wessel Lab Team

    2015-03-01

    A long-standing hypothesis at the interface of physics and neuroscience is that neural networks self-organize to the critical point of a phase transition, thereby optimizing aspects of sensory information processing. This idea is partially supported by strong evidence for critical dynamics observed in the cerebral cortex, but has not been tested in systems with significant sensory input. Thus, the foundations of this hypothesis - the self-organization process and how it manifests during strong sensory input - remain unstudied experimentally. Here we report microelectrode array measurements from visual cortex of turtles during visual stimulation of the retina. We show experimentally and in a computational model that strong sensory input initially elicits cortical network dynamics that are not critical, but adaptive changes in the network rapidly tune the system to criticality. This conclusion is based on observations of multifaceted scaling laws predicted to occur at criticality. Our findings establish sensory adaptation as a self-organizing mechanism which maintains criticality in visual cortex during sensory information processing. Supported by NSF CRCNS Grant 1308174.

  6. Designing sustainable soils in Earth's critical zone

    NASA Astrophysics Data System (ADS)

    Banwart, Steven Allan; de Souza, Danielle Maia; Menon, Manoj; Nikolaidis, Nikolaos; Panagos, Panos; Vala Ragnardsdottir, Kristin; Rousseva, Svelta; van Gaans, Pauline

    2014-05-01

    The demographic drivers of increasing human population and wealth are creating tremendous environmental pressures from growing intensity of land use, resulting in soil and land degradation worldwide. Environmental services are provided through multiple soil functions that include biomass production, water storage and transmission, nutrient transformations, contaminant attenuation, carbon and nitrogen storage, providing habitat and maintaining the genetic diversity of the land environment. One of the greatest challenges of the 21st century is to identify key risks to soil, and to design mitigation strategies to manage these risks and to enhance soil functions that can last into the future. The scientific study of Earth's Critical Zone (CZ), the thin surface layer that extends vertically from the top of the tree canopy to the bottom of aquifers, provides an essential integrating scientific framework to study, protect and enhance soil functions. The research hypothesis is that soil structure, the geometric architecture of solids, pores and biomass, is a critical indicator and essential factor of productive soil functions. The experimental design selects a network of Critical Zone Observatories (CZOs) as advanced field research sites along a gradient of land use intensity in order to quantify soil structure and soil processes that dictate the flows and transformations of material and energy as soil functions. The CZOs focus multidisciplinary expertise on soil processes, field observation and data interpretation, management science and ecological economics. Computational simulation of biophysical processes provides a quantitative method of integration for the range of theory and observations that are required to quantify the linkages between changes in soil structure and soil functions. Key results demonstrate that changes in soil structure can be quantified through the inputs of organic carbon and nitrogen from plant productivity and microbial activity, coupled with

  7. Dynamic optimization and adaptive controller design

    NASA Astrophysics Data System (ADS)

    Inamdar, S. R.

    2010-10-01

    In this work I present a new type of controller which is an adaptive tracking controller which employs dynamic optimization for optimizing current value of controller action for the temperature control of nonisothermal continuously stirred tank reactor (CSTR). We begin with a two-state model of nonisothermal CSTR which are mass and heat balance equations and then add cooling system dynamics to eliminate input multiplicity. The initial design value is obtained using local stability of steady states where approach temperature for cooling action is specified as a steady state and a design specification. Later we make a correction in the dynamics where material balance is manipulated to use feed concentration as a system parameter as an adaptive control measure in order to avoid actuator saturation for the main control loop. The analysis leading to design of dynamic optimization based parameter adaptive controller is presented. The important component of this mathematical framework is reference trajectory generation to form an adaptive control measure.

  8. Adaptation to different noninvasive ventilation masks in critically ill patients*

    PubMed Central

    da Silva, Renata Matos; Timenetsky, Karina Tavares; Neves, Renata Cristina Miranda; Shigemichi, Liane Hirano; Kanda, Sandra Sayuri; Maekawa, Carla; Silva, Eliezer; Eid, Raquel Afonso Caserta

    2013-01-01

    OBJECTIVE: To identify which noninvasive ventilation (NIV) masks are most commonly used and the problems related to the adaptation to such masks in critically ill patients admitted to a hospital in the city of São Paulo, Brazil. METHODS: An observational study involving patients ≥ 18 years of age admitted to intensive care units and submitted to NIV. The reason for NIV use, type of mask, NIV regimen, adaptation to the mask, and reasons for non-adaptation to the mask were investigated. RESULTS: We evaluated 245 patients, with a median age of 82 years. Acute respiratory failure was the most common reason for NIV use (in 71.3%). Total face masks were the most commonly used (in 74.7%), followed by full face masks and near-total face masks (in 24.5% and 0.8%, respectively). Intermittent NIV was used in 82.4% of the patients. Adequate adaptation to the mask was found in 76% of the patients. Masks had to be replaced by another type of mask in 24% of the patients. Adequate adaptation to total face masks and full face masks was found in 75.5% and 80.0% of the patients, respectively. Non-adaptation occurred in the 2 patients using near-total facial masks. The most common reason for non-adaptation was the shape of the face, in 30.5% of the patients. CONCLUSIONS: In our sample, acute respiratory failure was the most common reason for NIV use, and total face masks were the most commonly used. The most common reason for non-adaptation to the mask was the shape of the face, which was resolved by changing the type of mask employed. PMID:24068269

  9. Synaptic plasticity enables adaptive self-tuning critical networks.

    PubMed

    Stepp, Nigel; Plenz, Dietmar; Srinivasa, Narayan

    2015-01-01

    During rest, the mammalian cortex displays spontaneous neural activity. Spiking of single neurons during rest has been described as irregular and asynchronous. In contrast, recent in vivo and in vitro population measures of spontaneous activity, using the LFP, EEG, MEG or fMRI suggest that the default state of the cortex is critical, manifested by spontaneous, scale-invariant, cascades of activity known as neuronal avalanches. Criticality keeps a network poised for optimal information processing, but this view seems to be difficult to reconcile with apparently irregular single neuron spiking. Here, we simulate a 10,000 neuron, deterministic, plastic network of spiking neurons. We show that a combination of short- and long-term synaptic plasticity enables these networks to exhibit criticality in the face of intrinsic, i.e. self-sustained, asynchronous spiking. Brief external perturbations lead to adaptive, long-term modification of intrinsic network connectivity through long-term excitatory plasticity, whereas long-term inhibitory plasticity enables rapid self-tuning of the network back to a critical state. The critical state is characterized by a branching parameter oscillating around unity, a critical exponent close to -3/2 and a long tail distribution of a self-similarity parameter between 0.5 and 1. PMID:25590427

  10. Synaptic Plasticity Enables Adaptive Self-Tuning Critical Networks

    PubMed Central

    Stepp, Nigel; Plenz, Dietmar; Srinivasa, Narayan

    2015-01-01

    During rest, the mammalian cortex displays spontaneous neural activity. Spiking of single neurons during rest has been described as irregular and asynchronous. In contrast, recent in vivo and in vitro population measures of spontaneous activity, using the LFP, EEG, MEG or fMRI suggest that the default state of the cortex is critical, manifested by spontaneous, scale-invariant, cascades of activity known as neuronal avalanches. Criticality keeps a network poised for optimal information processing, but this view seems to be difficult to reconcile with apparently irregular single neuron spiking. Here, we simulate a 10,000 neuron, deterministic, plastic network of spiking neurons. We show that a combination of short- and long-term synaptic plasticity enables these networks to exhibit criticality in the face of intrinsic, i.e. self-sustained, asynchronous spiking. Brief external perturbations lead to adaptive, long-term modification of intrinsic network connectivity through long-term excitatory plasticity, whereas long-term inhibitory plasticity enables rapid self-tuning of the network back to a critical state. The critical state is characterized by a branching parameter oscillating around unity, a critical exponent close to -3/2 and a long tail distribution of a self-similarity parameter between 0.5 and 1. PMID:25590427

  11. Critical thinking: optimal outcomes through end user involvement in the design of critical care areas.

    PubMed

    Braun, Debra; Barnhardt, Kim

    2014-01-01

    Including end users in evidence-based design is vital to outcomes. The physical environment impacts caregiver efficiencies, safety, satisfaction, and quality of patient outcomes. End users are more than members of the organization: patients should have representation as well. Patients bring value by offering insight from a different perspective. Timing is key; therefore, it is critical in obtaining desired outcomes, to include end users as early as possible, gaining the most insight into the design of the build. Consideration should also be given to best practice standards, regulatory compliance, progressive sciences, and technologies. Another vital factor is education of the end users on their role and expectations for participation in a design team. When end users are educated and understand the significance of input, the design team will be able to conceive a critical care unit that will meet needs for today and be able to adapt to needs for the future.

  12. Critical thinking: optimal outcomes through end user involvement in the design of critical care areas.

    PubMed

    Braun, Debra; Barnhardt, Kim

    2014-01-01

    Including end users in evidence-based design is vital to outcomes. The physical environment impacts caregiver efficiencies, safety, satisfaction, and quality of patient outcomes. End users are more than members of the organization: patients should have representation as well. Patients bring value by offering insight from a different perspective. Timing is key; therefore, it is critical in obtaining desired outcomes, to include end users as early as possible, gaining the most insight into the design of the build. Consideration should also be given to best practice standards, regulatory compliance, progressive sciences, and technologies. Another vital factor is education of the end users on their role and expectations for participation in a design team. When end users are educated and understand the significance of input, the design team will be able to conceive a critical care unit that will meet needs for today and be able to adapt to needs for the future. PMID:24309458

  13. Design of Low Complexity Model Reference Adaptive Controllers

    NASA Technical Reports Server (NTRS)

    Hanson, Curt; Schaefer, Jacob; Johnson, Marcus; Nguyen, Nhan

    2012-01-01

    Flight research experiments have demonstrated that adaptive flight controls can be an effective technology for improving aircraft safety in the event of failures or damage. However, the nonlinear, timevarying nature of adaptive algorithms continues to challenge traditional methods for the verification and validation testing of safety-critical flight control systems. Increasingly complex adaptive control theories and designs are emerging, but only make testing challenges more difficult. A potential first step toward the acceptance of adaptive flight controllers by aircraft manufacturers, operators, and certification authorities is a very simple design that operates as an augmentation to a non-adaptive baseline controller. Three such controllers were developed as part of a National Aeronautics and Space Administration flight research experiment to determine the appropriate level of complexity required to restore acceptable handling qualities to an aircraft that has suffered failures or damage. The controllers consist of the same basic design, but incorporate incrementally-increasing levels of complexity. Derivations of the controllers and their adaptive parameter update laws are presented along with details of the controllers implementations.

  14. Adaptive Strategies for Materials Design using Uncertainties.

    PubMed

    Balachandran, Prasanna V; Xue, Dezhen; Theiler, James; Hogden, John; Lookman, Turab

    2016-01-21

    We compare several adaptive design strategies using a data set of 223 M2AX family of compounds for which the elastic properties [bulk (B), shear (G), and Young's (E) modulus] have been computed using density functional theory. The design strategies are decomposed into an iterative loop with two main steps: machine learning is used to train a regressor that predicts elastic properties in terms of elementary orbital radii of the individual components of the materials; and a selector uses these predictions and their uncertainties to choose the next material to investigate. The ultimate goal is to obtain a material with desired elastic properties in as few iterations as possible. We examine how the choice of data set size, regressor and selector impact the design. We find that selectors that use information about the prediction uncertainty outperform those that don't. Our work is a step in illustrating how adaptive design tools can guide the search for new materials with desired properties.

  15. Flexible receiver adapter formal design review

    SciTech Connect

    Krieg, S.A.

    1995-06-13

    This memo summarizes the results of the Formal (90%) Design Review process and meetings held to evaluate the design of the Flexible Receiver Adapters, support platforms, and associated equipment. The equipment is part of the Flexible Receiver System used to remove, transport, and store long length contaminated equipment and components from both the double and single-shell underground storage tanks at the 200 area tank farms.

  16. Computerized Adaptive Testing System Design: Preliminary Design Considerations.

    ERIC Educational Resources Information Center

    Croll, Paul R.

    A functional design model for a computerized adaptive testing (CAT) system was developed and presented through a series of hierarchy plus input-process-output (HIPO) diagrams. System functions were translated into system structure: specifically, into 34 software components. Implementation of the design in a physical system was addressed through…

  17. Design considerations for CELT adaptive optics

    NASA Astrophysics Data System (ADS)

    Dekany, Richard G.; Nelson, Jerry E.; Bauman, Brian J.

    2000-07-01

    California Institute of Technology and University of California have begun conceptual design studies for a new telescope for astronomical research at visible and infrared wavelengths. The California Extremely Large Telescope (CELT) is currently envisioned as a filled-aperture, steerable, segmented telescope of approximately 30 m diameter. The key to satisfying many of the science goals of this observatory is the availability of diffraction-limited wavefront control. We describe potential observing modes of CELT, including a discussion of the several major outstanding AO system architectural design issues to be resolved prior to the initiation of the detailed design of the adaptive optics capability.

  18. Numerical design of an adaptive aileron

    NASA Astrophysics Data System (ADS)

    Amendola, Gianluca; Dimino, Ignazio; Concilio, Antonio; Magnifico, Marco; Pecora, Rosario

    2016-04-01

    The study herein described is aimed at investigating the feasibility of an innovative full-scale camber morphing aileron device. In the framework of the "Adaptive Aileron" project, an international cooperation between Italy and Canada, this goal was carried out with the integration of different morphing concepts in a wing-tip prototype. As widely demonstrated in recent European projects such as Clean Sky JTI and SARISTU, wing trailing edge morphing may lead to significant drag reduction (up to 6%) in off-design flight points by adapting chord-wise camber variations in cruise to compensate A/C weight reduction following fuel consumption. Those researches focused on the flap region as the most immediate solution to implement structural adaptations. However, there is also a growing interest in extending morphing functionalities to the aileron region preserving its main functionality in controlling aircraft directional stability. In fact, the external region of the wing seems to be the most effective in producing "lift over drag" improvements by morphing. Thus, the objective of the presented research is to achieve a certain drag reduction in off-design flight points by adapting wing shape and lift distribution following static deflections. In perspective, the developed device could also be used as a load alleviation system to reduce gust effects, augmenting its frequency bandwidth. In this paper, the preliminary design of the adaptive aileron is first presented, assessed on the base of the external aerodynamic loads. The primary structure is made of 5 segmented ribs, distributed along 4 bays, each splitted into three consecutive parts, connected with spanwise stringers. The aileron shape modification is then implemented by means of an actuation system, based on a classical quick-return mechanism, opportunely suited for the presented application. Finite element analyses were assessed for properly sizing the load-bearing structure and actuation systems and for

  19. Adaptive control design for hysteretic smart systems

    NASA Astrophysics Data System (ADS)

    McMahan, Jerry A.; Smith, Ralph C.

    2011-04-01

    Ferroelectric and ferromagnetic actuators are being considered for a range of industrial, aerospace, aeronautic and biomedical applications due to their unique transduction capabilities. However, they also exhibit hysteretic and nonlinear behavior that must be accommodated in models and control designs. If uncompensated, these effects can yield reduced system performance and, in the worst case, can produce unpredictable behavior of the control system. In this paper, we address the development of adaptive control designs for hysteretic systems. We review an MRAC-like adaptive control algorithm used to track a reference trajectory while computing online estimates for certain model parameters. This method is incorporated in a composite control algorithm to improve the tracking capabilities of the system. Issues arising in the implementation of these algorithms are addressed, and a numerical example is presented, comparing the results of each method.

  20. Guideline For Design Of Adaptive Structures

    NASA Technical Reports Server (NTRS)

    Utku, Senol; Wada, Ben K.

    1994-01-01

    Guideline for design of adaptive structures specifies active members should be located at positions of maximum strain energy. Equations of motion of flexible structures formulated in terms of kinetic energies, strain energies, and direct measurements of forces. Maintaining precise dimensional control during assembly essential to assembly without large external loads or to prevent jamming of substructure preventing successful deployment. Active members used to prevent "binding" during deployment of structure. Then structure adjusted to precision shape requirement and adjusted during operation as required.

  1. Criticality as a Set-Point for Adaptive Behavior in Neuromorphic Hardware

    PubMed Central

    Srinivasa, Narayan; Stepp, Nigel D.; Cruz-Albrecht, Jose

    2015-01-01

    Neuromorphic hardware are designed by drawing inspiration from biology to overcome limitations of current computer architectures while forging the development of a new class of autonomous systems that can exhibit adaptive behaviors. Several designs in the recent past are capable of emulating large scale networks but avoid complexity in network dynamics by minimizing the number of dynamic variables that are supported and tunable in hardware. We believe that this is due to the lack of a clear understanding of how to design self-tuning complex systems. It has been widely demonstrated that criticality appears to be the default state of the brain and manifests in the form of spontaneous scale-invariant cascades of neural activity. Experiment, theory and recent models have shown that neuronal networks at criticality demonstrate optimal information transfer, learning and information processing capabilities that affect behavior. In this perspective article, we argue that understanding how large scale neuromorphic electronics can be designed to enable emergent adaptive behavior will require an understanding of how networks emulated by such hardware can self-tune local parameters to maintain criticality as a set-point. We believe that such capability will enable the design of truly scalable intelligent systems using neuromorphic hardware that embrace complexity in network dynamics rather than avoiding it. PMID:26648839

  2. Criticality as a Set-Point for Adaptive Behavior in Neuromorphic Hardware.

    PubMed

    Srinivasa, Narayan; Stepp, Nigel D; Cruz-Albrecht, Jose

    2015-01-01

    Neuromorphic hardware are designed by drawing inspiration from biology to overcome limitations of current computer architectures while forging the development of a new class of autonomous systems that can exhibit adaptive behaviors. Several designs in the recent past are capable of emulating large scale networks but avoid complexity in network dynamics by minimizing the number of dynamic variables that are supported and tunable in hardware. We believe that this is due to the lack of a clear understanding of how to design self-tuning complex systems. It has been widely demonstrated that criticality appears to be the default state of the brain and manifests in the form of spontaneous scale-invariant cascades of neural activity. Experiment, theory and recent models have shown that neuronal networks at criticality demonstrate optimal information transfer, learning and information processing capabilities that affect behavior. In this perspective article, we argue that understanding how large scale neuromorphic electronics can be designed to enable emergent adaptive behavior will require an understanding of how networks emulated by such hardware can self-tune local parameters to maintain criticality as a set-point. We believe that such capability will enable the design of truly scalable intelligent systems using neuromorphic hardware that embrace complexity in network dynamics rather than avoiding it. PMID:26648839

  3. Probabilistic dual heuristic programming-based adaptive critic

    NASA Astrophysics Data System (ADS)

    Herzallah, Randa

    2010-02-01

    Adaptive critic (AC) methods have common roots as generalisations of dynamic programming for neural reinforcement learning approaches. Since they approximate the dynamic programming solutions, they are potentially suitable for learning in noisy, non-linear and non-stationary environments. In this study, a novel probabilistic dual heuristic programming (DHP)-based AC controller is proposed. Distinct to current approaches, the proposed probabilistic (DHP) AC method takes uncertainties of forward model and inverse controller into consideration. Therefore, it is suitable for deterministic and stochastic control problems characterised by functional uncertainty. Theoretical development of the proposed method is validated by analytically evaluating the correct value of the cost function which satisfies the Bellman equation in a linear quadratic control problem. The target value of the probabilistic critic network is then calculated and shown to be equal to the analytically derived correct value. Full derivation of the Riccati solution for this non-standard stochastic linear quadratic control problem is also provided. Moreover, the performance of the proposed probabilistic controller is demonstrated on linear and non-linear control examples.

  4. Adaptive Strategies for Materials Design using Uncertainties

    NASA Astrophysics Data System (ADS)

    Balachandran, Prasanna V.; Xue, Dezhen; Theiler, James; Hogden, John; Lookman, Turab

    2016-01-01

    We compare several adaptive design strategies using a data set of 223 M2AX family of compounds for which the elastic properties [bulk (B), shear (G), and Young’s (E) modulus] have been computed using density functional theory. The design strategies are decomposed into an iterative loop with two main steps: machine learning is used to train a regressor that predicts elastic properties in terms of elementary orbital radii of the individual components of the materials; and a selector uses these predictions and their uncertainties to choose the next material to investigate. The ultimate goal is to obtain a material with desired elastic properties in as few iterations as possible. We examine how the choice of data set size, regressor and selector impact the design. We find that selectors that use information about the prediction uncertainty outperform those that don’t. Our work is a step in illustrating how adaptive design tools can guide the search for new materials with desired properties.

  5. Adaptive Strategies for Materials Design using Uncertainties

    PubMed Central

    Balachandran, Prasanna V.; Xue, Dezhen; Theiler, James; Hogden, John; Lookman, Turab

    2016-01-01

    We compare several adaptive design strategies using a data set of 223 M2AX family of compounds for which the elastic properties [bulk (B), shear (G), and Young’s (E) modulus] have been computed using density functional theory. The design strategies are decomposed into an iterative loop with two main steps: machine learning is used to train a regressor that predicts elastic properties in terms of elementary orbital radii of the individual components of the materials; and a selector uses these predictions and their uncertainties to choose the next material to investigate. The ultimate goal is to obtain a material with desired elastic properties in as few iterations as possible. We examine how the choice of data set size, regressor and selector impact the design. We find that selectors that use information about the prediction uncertainty outperform those that don’t. Our work is a step in illustrating how adaptive design tools can guide the search for new materials with desired properties. PMID:26792532

  6. Adaptive strategies for materials design using uncertainties

    DOE PAGES

    Balachandran, Prasanna V.; Xue, Dezhen; Theiler, James; Hogden, John; Lookman, Turab

    2016-01-21

    Here, we compare several adaptive design strategies using a data set of 223 M2AX family of compounds for which the elastic properties [bulk (B), shear (G), and Young’s (E) modulus] have been computed using density functional theory. The design strategies are decomposed into an iterative loop with two main steps: machine learning is used to train a regressor that predicts elastic properties in terms of elementary orbital radii of the individual components of the materials; and a selector uses these predictions and their uncertainties to choose the next material to investigate. The ultimate goal is to obtain a material withmore » desired elastic properties in as few iterations as possible. We examine how the choice of data set size, regressor and selector impact the design. We find that selectors that use information about the prediction uncertainty outperform those that don’t. Our work is a step in illustrating how adaptive design tools can guide the search for new materials with desired properties.« less

  7. A layered architecture for critical database design

    SciTech Connect

    Chisholm, G.H.; Swietlik, C.E.

    1997-12-31

    Integrity, security, and safety are desired properties of database systems destined for use in critical applications. These properties are desirable because they determine a system`s credibility. However, demonstrating that a system does, in fact, preserve these properties when implemented is a difficult task. The difficulty depends on the complexity of the associated design. The authors explore architectural paradigms that have been demonstrated to reduce system complexity and, thus, reduce the cost associated with certifying that the above properties are present in the final implementation. The approach is based on the tenet that the design is divided into multiple layers. The critical functions and data make up the bottom layer, where the requirements for integrity, security, and safety are most rigid. Certification is dependent on the use of formal methods to specify and analyze the system. Appropriate formal methods are required to support certification that multiple properties are present in the final implementation. These methods must assure a rigid mapping from the top-level specification down through the implementation details. Application of a layered architecture reduces the scope of the design that must be formally specified and analyzed. This paper describes a generic, layered architecture and a formal model for specification and analysis of complex systems that require rigid integrity security, and safety properties.

  8. Adaptive Mesh Refinement for Microelectronic Device Design

    NASA Technical Reports Server (NTRS)

    Cwik, Tom; Lou, John; Norton, Charles

    1999-01-01

    Finite element and finite volume methods are used in a variety of design simulations when it is necessary to compute fields throughout regions that contain varying materials or geometry. Convergence of the simulation can be assessed by uniformly increasing the mesh density until an observable quantity stabilizes. Depending on the electrical size of the problem, uniform refinement of the mesh may be computationally infeasible due to memory limitations. Similarly, depending on the geometric complexity of the object being modeled, uniform refinement can be inefficient since regions that do not need refinement add to the computational expense. In either case, convergence to the correct (measured) solution is not guaranteed. Adaptive mesh refinement methods attempt to selectively refine the region of the mesh that is estimated to contain proportionally higher solution errors. The refinement may be obtained by decreasing the element size (h-refinement), by increasing the order of the element (p-refinement) or by a combination of the two (h-p refinement). A successful adaptive strategy refines the mesh to produce an accurate solution measured against the correct fields without undue computational expense. This is accomplished by the use of a) reliable a posteriori error estimates, b) hierarchal elements, and c) automatic adaptive mesh generation. Adaptive methods are also useful when problems with multi-scale field variations are encountered. These occur in active electronic devices that have thin doped layers and also when mixed physics is used in the calculation. The mesh needs to be fine at and near the thin layer to capture rapid field or charge variations, but can coarsen away from these layers where field variations smoothen and charge densities are uniform. This poster will present an adaptive mesh refinement package that runs on parallel computers and is applied to specific microelectronic device simulations. Passive sensors that operate in the infrared portion of

  9. Adaptive Modeling, Engineering Analysis and Design of Advanced Aerospace Vehicles

    NASA Technical Reports Server (NTRS)

    Mukhopadhyay, Vivek; Hsu, Su-Yuen; Mason, Brian H.; Hicks, Mike D.; Jones, William T.; Sleight, David W.; Chun, Julio; Spangler, Jan L.; Kamhawi, Hilmi; Dahl, Jorgen L.

    2006-01-01

    This paper describes initial progress towards the development and enhancement of a set of software tools for rapid adaptive modeling, and conceptual design of advanced aerospace vehicle concepts. With demanding structural and aerodynamic performance requirements, these high fidelity geometry based modeling tools are essential for rapid and accurate engineering analysis at the early concept development stage. This adaptive modeling tool was used for generating vehicle parametric geometry, outer mold line and detailed internal structural layout of wing, fuselage, skin, spars, ribs, control surfaces, frames, bulkheads, floors, etc., that facilitated rapid finite element analysis, sizing study and weight optimization. The high quality outer mold line enabled rapid aerodynamic analysis in order to provide reliable design data at critical flight conditions. Example application for structural design of a conventional aircraft and a high altitude long endurance vehicle configuration are presented. This work was performed under the Conceptual Design Shop sub-project within the Efficient Aerodynamic Shape and Integration project, under the former Vehicle Systems Program. The project objective was to design and assess unconventional atmospheric vehicle concepts efficiently and confidently. The implementation may also dramatically facilitate physics-based systems analysis for the NASA Fundamental Aeronautics Mission. In addition to providing technology for design and development of unconventional aircraft, the techniques for generation of accurate geometry and internal sub-structure and the automated interface with the high fidelity analysis codes could also be applied towards the design of vehicles for the NASA Exploration and Space Science Mission projects.

  10. A Tutorial on Adaptive Design Optimization

    PubMed Central

    Myung, Jay I.; Cavagnaro, Daniel R.; Pitt, Mark A.

    2013-01-01

    Experimentation is ubiquitous in the field of psychology and fundamental to the advancement of its science, and one of the biggest challenges for researchers is designing experiments that can conclusively discriminate the theoretical hypotheses or models under investigation. The recognition of this challenge has led to the development of sophisticated statistical methods that aid in the design of experiments and that are within the reach of everyday experimental scientists. This tutorial paper introduces the reader to an implementable experimentation methodology, dubbed Adaptive Design Optimization, that can help scientists to conduct “smart” experiments that are maximally informative and highly efficient, which in turn should accelerate scientific discovery in psychology and beyond. PMID:23997275

  11. Adaptive design of visual perception experiments

    NASA Astrophysics Data System (ADS)

    O'Connor, John D.; Hixson, Jonathan; Thomas, James M., Jr.; Peterson, Matthew S.; Parasuraman, Raja

    2010-04-01

    Meticulous experimental design may not always prevent confounds from affecting experimental data acquired during visual perception experiments. Although experimental controls reduce the potential effects of foreseen sources of interference, interaction, or noise, they are not always adequate for preventing the confounding effects of unforeseen forces. Visual perception experimentation is vulnerable to unforeseen confounds because of the nature of the associated cognitive processes involved in the decision task. Some confounds are beyond the control of experimentation, such as what a participant does immediately prior to experimental participation, or the participant's attitude or emotional state. Other confounds may occur through ignorance of practical control methods on the part of the experiment's designer. The authors conducted experiments related to experimental fatigue and initially achieved significant results that were, upon re-examination, attributable to a lack of adequate controls. Re-examination of the original results and the processes and events that led to them yielded a second experimental design with more experimental controls and significantly different results. The authors propose that designers of visual perception experiments can benefit from planning to use a test-fix-test or adaptive experimental design cycle, so that unforeseen confounds in the initial design can be remedied.

  12. The Design and the Formative Evaluation of an Adaptive Educational System Based on Cognitive Styles

    ERIC Educational Resources Information Center

    Triantafillou, Evangelos; Pomportsis, Andreas; Demetriadis, Stavros

    2003-01-01

    Adaptive Hypermedia Systems (AHS) can be developed to accommodate a variety of individual differences, including learning style and cognitive style. The current research is an attempt to examine some of the critical variables, which may be important in the design of an Adaptive Educational System (AES) based on student's cognitive style. Moreover,…

  13. Potential of adaptive clinical trial designs in pharmacogenetic research.

    PubMed

    van der Baan, Frederieke H; Knol, Mirjam J; Klungel, Olaf H; Egberts, Antoine Cg; Grobbee, Diederick E; Roes, Kit C B

    2012-04-01

    Adaptive trial designs can be beneficial in pharmacogenetic research when prior uncertainty exists regarding the exact role and clinical relevance of genetic variability in drug response. This type of design enables us to learn about the effect of the genetic variability on drug response and to immediately use this information for the remainder of the study. For different types of adaptive trial designs, we discuss when and how the designs are suitable for pharmacogenetic research: adaptation of randomization, adaptation of patient enrollment and adaptive enrichment. To illustrate the potential benefits of an adaptive design over a fixed design, we simulated an adaptive trial based on the results of the IPASS trial. With a simple model we show that for this example an adaptive enrichment design would have led to a smaller trial, with less EGF receptor mutation-negative patients unnecessarily exposed to the drug, without compromising the α level or reducing power. PMID:22462749

  14. Valuation of design adaptability in aerospace systems

    NASA Astrophysics Data System (ADS)

    Fernandez Martin, Ismael

    As more information is brought into early stages of the design, more pressure is put on engineers to produce a reliable, high quality, and financially sustainable product. Unfortunately, requirements established at the beginning of a new project by customers, and the environment that surrounds them, continue to change in some unpredictable ways. The risk of designing a system that may become obsolete during early stages of production is currently tackled by the use of robust design simulation, a method that allows to simultaneously explore a plethora of design alternatives and requirements with the intention of accounting for uncertain factors in the future. Whereas this design technique has proven to be quite an improvement in design methods, under certain conditions, it fails to account for the change of uncertainty over time and the intrinsic value embedded in the system when certain design features are activated. This thesis introduces the concepts of adaptability and real options to manage risk foreseen in the face of uncertainty at early design stages. The method described herein allows decision-makers to foresee the financial impact of their decisions at the design level, as well as the final exposure to risk. In this thesis, cash flow models, traditionally used to obtain the forecast of a project's value over the years, were replaced with surrogate models that are capable of showing fluctuations on value every few days. This allowed a better implementation of real options valuation, optimization, and strategy selection. Through the option analysis model, an optimization exercise allows the user to obtain the best implementation strategy in the face of uncertainty as well as the overall value of the design feature. Here implementation strategy refers to the decision to include a new design feature in the system, after the design has been finalized, but before the end of its production life. The ability to do this in a cost efficient manner after the system

  15. Designing a VMEbus FDDI adapter card

    NASA Astrophysics Data System (ADS)

    Venkataraman, Raman

    1992-03-01

    This paper presents a system architecture for a VMEbus FDDI adapter card containing a node core, FDDI block, frame buffer memory and system interface unit. Most of the functions of the PHY and MAC layers of FDDI are implemented with National's FDDI chip set and the SMT implementation is simplified with a low cost microcontroller. The factors that influence the system bus bandwidth utilization and FDDI bandwidth utilization are the data path and frame buffer memory architecture. The VRAM based frame buffer memory has two sections - - LLC frame memory and SMT frame memory. Each section with an independent serial access memory (SAM) port provides an independent access after the initial data transfer cycle on the main port and hence, the throughput is maximized on each port of the memory. The SAM port simplifies the system bus master DMA design and the VMEbus interface can be designed with low-cost off-the-shelf interface chips.

  16. Adaptive Critic Neural Network-Based Terminal Area Energy Management and Approach and Landing Guidance

    NASA Technical Reports Server (NTRS)

    Grantham, Katie

    2003-01-01

    Reusable Launch Vehicles (RLVs) have different mission requirements than the Space Shuttle, which is used for benchmark guidance design. Therefore, alternative Terminal Area Energy Management (TAEM) and Approach and Landing (A/L) Guidance schemes can be examined in the interest of cost reduction. A neural network based solution for a finite horizon trajectory optimization problem is presented in this paper. In this approach the optimal trajectory of the vehicle is produced by adaptive critic based neural networks, which were trained off-line to maintain a gradual glideslope.

  17. Network inference via adaptive optimal design

    PubMed Central

    2012-01-01

    Background Current research in network reverse engineering for genetic or metabolic networks very often does not include a proper experimental and/or input design. In this paper we address this issue in more detail and suggest a method that includes an iterative design of experiments based, on the most recent data that become available. The presented approach allows a reliable reconstruction of the network and addresses an important issue, i.e., the analysis and the propagation of uncertainties as they exist in both the data and in our own knowledge. These two types of uncertainties have their immediate ramifications for the uncertainties in the parameter estimates and, hence, are taken into account from the very beginning of our experimental design. Findings The method is demonstrated for two small networks that include a genetic network for mRNA synthesis and degradation and an oscillatory network describing a molecular network underlying adenosine 3’-5’ cyclic monophosphate (cAMP) as observed in populations of Dyctyostelium cells. In both cases a substantial reduction in parameter uncertainty was observed. Extension to larger scale networks is possible but needs a more rigorous parameter estimation algorithm that includes sparsity as a constraint in the optimization procedure. Conclusion We conclude that a careful experiment design very often (but not always) pays off in terms of reliability in the inferred network topology. For large scale networks a better parameter estimation algorithm is required that includes sparsity as an additional constraint. These algorithms are available in the literature and can also be used in an adaptive optimal design setting as demonstrated in this paper. PMID:22999252

  18. Test Information Targeting Strategies for Adaptive Multistage Testing Designs.

    ERIC Educational Resources Information Center

    Luecht, Richard M.; Burgin, William

    Adaptive multistage testlet (MST) designs appear to be gaining popularity for many large-scale computer-based testing programs. These adaptive MST designs use a modularized configuration of preconstructed testlets and embedded score-routing schemes to prepackage different forms of an adaptive test. The conditional information targeting (CIT)…

  19. Adaptive critic learning techniques for engine torque and air-fuel ratio control.

    PubMed

    Liu, Derong; Javaherian, Hossein; Kovalenko, Olesia; Huang, Ting

    2008-08-01

    A new approach for engine calibration and control is proposed. In this paper, we present our research results on the implementation of adaptive critic designs for self-learning control of automotive engines. A class of adaptive critic designs that can be classified as (model-free) action-dependent heuristic dynamic programming is used in this research project. The goals of the present learning control design for automotive engines include improved performance, reduced emissions, and maintained optimum performance under various operating conditions. Using the data from a test vehicle with a V8 engine, we developed a neural network model of the engine and neural network controllers based on the idea of approximate dynamic programming to achieve optimal control. We have developed and simulated self-learning neural network controllers for both engine torque (TRQ) and exhaust air-fuel ratio (AFR) control. The goal of TRQ control and AFR control is to track the commanded values. For both control problems, excellent neural network controller transient performance has been achieved.

  20. Adapting the Critical Thinking Assessment Test for Palestinian Universities

    ERIC Educational Resources Information Center

    Basha, Sami; Drane, Denise; Light, Gregory

    2016-01-01

    Critical thinking is a key learning outcome for Palestinian students. However, there are no validated critical thinking tests in Arabic. Suitability of the US developed Critical Thinking Assessment Test (CAT) for use in Palestine was assessed. The test was piloted with university students in English (n = 30) and 4 questions were piloted in Arabic…

  1. Issues and Challenges in the Design of Culturally Adapted Evidence-Based Interventions

    PubMed Central

    Castro, Felipe González; Barrera, Manuel; Holleran Steiker, Lori K.

    2014-01-01

    This article examines issues and challenges in the design of cultural adaptations that are developed from an original evidence-based intervention (EBI). Recently emerging multistep frameworks or stage models are examined, as these can systematically guide the development of culturally adapted EBIs. Critical issues are also presented regarding whether and how such adaptations may be conducted, and empirical evidence is presented regarding the effectiveness of such cultural adaptations. Recent evidence suggests that these cultural adaptations are effective when applied with certain subcultural groups, although they are less effective when applied with other subcultural groups. Generally, current evidence regarding the effectiveness of cultural adaptations is promising but mixed. Further research is needed to obtain more definitive conclusions regarding the efficacy and effectiveness of culturally adapted EBIs. Directions for future research and recommendations are presented to guide the development of a new generation of culturally adapted EBIs. PMID:20192800

  2. Adaptive information design for outdoor augmented reality.

    PubMed

    Neuhöfer, Jan A; Govaers, Felix; El Mokni, Hichem; Alexander, Thomas

    2012-01-01

    Augmented Reality focuses on the enrichment of the user's natural field of view by consistent integration of text, symbols and interactive three-dimensional objects in real time. Placing virtual objects directly into the user's view in a natural context empowers highly dynamic applications. On the other hand, this necessitates deliberate choice of information design and density, in particular for deployment in hazardous environments like military combat scenarios. As the amount of information needed is not foreseeable and strongly depends on the individual mission, an appropriate system must offer adequate adaptation capabilities. The paper presents a prototypical, vehicle-mountable Augmented Reality vision system, designed for enhancing situation awareness in stressful urban warfare scenarios. Tracking, as one of the most crucial challenges for outdoor Augmented Reality, is accomplished by means of a Differential-GPS approach while the type of display to attach can be modified, ranging from ocular displays to standard LCD mini-screens. The overall concept also includes envisioning of own troops (blue forces), for which a multi-sensor tracking approach has been chosen. As a main feature, the system allows switching between different information categories, focusing on friendly, hostile, unidentified or neutral data. Results of an empirical study on the superiority of an in-view navigation cue approach conclude the paper.

  3. Launch vehicle payload adapter design with vibration isolation features

    NASA Astrophysics Data System (ADS)

    Thomas, Gareth R.; Fadick, Cynthia M.; Fram, Bryan J.

    2005-05-01

    Payloads, such as satellites or spacecraft, which are mounted on launch vehicles, are subject to severe vibrations during flight. These vibrations are induced by multiple sources that occur between liftoff and the instant of final separation from the launch vehicle. A direct result of the severe vibrations is that fatigue damage and failure can be incurred by sensitive payload components. For this reason a payload adapter has been designed with special emphasis on its vibration isolation characteristics. The design consists of an annular plate that has top and bottom face sheets separated by radial ribs and close-out rings. These components are manufactured from graphite epoxy composites to ensure a high stiffness to weight ratio. The design is tuned to keep the frequency of the axial mode of vibration of the payload on the flexibility of the adapter to a low value. This is the main strategy adopted for isolating the payload from damaging vibrations in the intermediate to higher frequency range (45Hz-200Hz). A design challenge for this type of adapter is to keep the pitch frequency of the payload above a critical value in order to avoid dynamic interactions with the launch vehicle control system. This high frequency requirement conflicts with the low axial mode frequency requirement and this problem is overcome by innovative tuning of the directional stiffnesses of the composite parts. A second design strategy that is utilized to achieve good isolation characteristics is the use of constrained layer damping. This feature is particularly effective at keeping the responses to a minimum for one of the most important dynamic loading mechanisms. This mechanism consists of the almost-tonal vibratory load associated with the resonant burn condition present in any stage powered by a solid rocket motor. The frequency of such a load typically falls in the 45-75Hz range and this phenomenon drives the low frequency design of the adapter. Detailed finite element analysis is

  4. Assessing Adaptive Instructional Design Tools and Methods in ADAPT[IT].

    ERIC Educational Resources Information Center

    Eseryel, Deniz; Spector, J. Michael

    ADAPT[IT] (Advanced Design Approach for Personalized Training - Interactive Tools) is a European project within the Information Society Technologies program that is providing design methods and tools to guide a training designer according to the latest cognitive science and standardization principles. ADAPT[IT] addresses users in two significantly…

  5. Adapting Entry-Level Engineering Courses to Emphasize Critical Thinking

    ERIC Educational Resources Information Center

    Hagerty, D. Joseph; Rockaway, Thomas D.

    2012-01-01

    The University of Louisville recently developed a Quality Enhancement Plan (QEP) to improve undergraduate instruction across all disciplines as part of its ongoing accreditation requirements. Central elements of the plan are emphasis on critical thinking; integration of critical thinking throughout the curriculum; service learning for…

  6. 50 CFR 424.12 - Criteria for designating critical habitat.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... designation of critical habitat shall be made on the basis of the best scientific data available, after taking..., geological formation, vegetation type, tide, and specific soil types. (c) Each critical habitat area will...

  7. 50 CFR 424.12 - Criteria for designating critical habitat.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... designation of critical habitat shall be made on the basis of the best scientific data available, after taking..., geological formation, vegetation type, tide, and specific soil types. (c) Each critical habitat will...

  8. 50 CFR 424.12 - Criteria for designating critical habitat.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... designation of critical habitat shall be made on the basis of the best scientific data available, after taking..., geological formation, vegetation type, tide, and specific soil types. (c) Each critical habitat will...

  9. 50 CFR 424.12 - Criteria for designating critical habitat.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... designation of critical habitat shall be made on the basis of the best scientific data available, after taking..., geological formation, vegetation type, tide, and specific soil types. (c) Each critical habitat area will...

  10. Designing and Implementing Effective Adapted Physical Education Programs

    ERIC Educational Resources Information Center

    Kelly, Luke E.

    2011-01-01

    "Designing and Implementing Effective Adapted Physical Education Programs" was written to assist adapted and general physical educators who are dedicated to ensuring that the physical and motor needs of all their students are addressed in physical education. While it is anticipated that adapted physical educators, where available, will typically…

  11. Design of a motion JPEG (M/JPEG) adapter card

    NASA Astrophysics Data System (ADS)

    Lee, D. H.; Sudharsanan, Subramania I.

    1994-05-01

    In this paper we describe a design of a high performance JPEG (Joint Photographic Experts Group) Micro Channel adapter card. The card, tested on a range of PS/2 platforms (models 50 to 95), can complete JPEG operations on a 640 by 240 pixel image within 1/60 of a second, thus enabling real-time capture and display of high quality digital video. The card accepts digital pixels for either a YUV 4:2:2 or an RGB 4:4:4 pixel bus and has been shown to handle up to 2.05 MBytes/second of compressed data. The compressed data is transmitted to a host memory area by Direct Memory Access operations. The card uses a single C-Cube's CL550 JPEG processor that complies with the baseline JPEG. We give broad descriptions of the hardware that controls the video interface, CL550, and the system interface. Some critical design points that enhance the overall performance of the M/JPEG systems are pointed out. The control of the adapter card is achieved by an interrupt driven software that runs under DOS. The software performs a variety of tasks that include change of color space (RGB or YUV), change of quantization and Huffman tables, odd and even field control and some diagnostic operations.

  12. Adaptive trial designs: a review of barriers and opportunities.

    PubMed

    Kairalla, John A; Coffey, Christopher S; Thomann, Mitchell A; Muller, Keith E

    2012-01-01

    Adaptive designs allow planned modifications based on data accumulating within a study. The promise of greater flexibility and efficiency stimulates increasing interest in adaptive designs from clinical, academic, and regulatory parties. When adaptive designs are used properly, efficiencies can include a smaller sample size, a more efficient treatment development process, and an increased chance of correctly answering the clinical question of interest. However, improper adaptations can lead to biased studies. A broad definition of adaptive designs allows for countless variations, which creates confusion as to the statistical validity and practical feasibility of many designs. Determining properties of a particular adaptive design requires careful consideration of the scientific context and statistical assumptions. We first review several adaptive designs that garner the most current interest. We focus on the design principles and research issues that lead to particular designs being appealing or unappealing in particular applications. We separately discuss exploratory and confirmatory stage designs in order to account for the differences in regulatory concerns. We include adaptive seamless designs, which combine stages in a unified approach. We also highlight a number of applied areas, such as comparative effectiveness research, that would benefit from the use of adaptive designs. Finally, we describe a number of current barriers and provide initial suggestions for overcoming them in order to promote wider use of appropriate adaptive designs. Given the breadth of the coverage all mathematical and most implementation details are omitted for the sake of brevity. However, the interested reader will find that we provide current references to focused reviews and original theoretical sources which lead to details of the current state of the art in theory and practice. PMID:22917111

  13. Paradigms for adaptive statistical information designs: practical experiences and strategies.

    PubMed

    Wang, Sue-Jane; Hung, H M James; O'Neill, Robert

    2012-11-10

    In the last decade or so, interest in adaptive design clinical trials has gradually been directed towards their use in regulatory submissions by pharmaceutical drug sponsors to evaluate investigational new drugs. Methodological advances of adaptive designs are abundant in the statistical literature since the 1970s. The adaptive design paradigm has been enthusiastically perceived to increase the efficiency and to be more cost-effective than the fixed design paradigm for drug development. Much interest in adaptive designs is in those studies with two-stages, where stage 1 is exploratory and stage 2 depends upon stage 1 results, but where the data of both stages will be combined to yield statistical evidence for use as that of a pivotal registration trial. It was not until the recent release of the US Food and Drug Administration Draft Guidance for Industry on Adaptive Design Clinical Trials for Drugs and Biologics (2010) that the boundaries of flexibility for adaptive designs were specifically considered for regulatory purposes, including what are exploratory goals, and what are the goals of adequate and well-controlled (A&WC) trials (2002). The guidance carefully described these distinctions in an attempt to minimize the confusion between the goals of preliminary learning phases of drug development, which are inherently substantially uncertain, and the definitive inference-based phases of drug development. In this paper, in addition to discussing some aspects of adaptive designs in a confirmatory study setting, we underscore the value of adaptive designs when used in exploratory trials to improve planning of subsequent A&WC trials. One type of adaptation that is receiving attention is the re-estimation of the sample size during the course of the trial. We refer to this type of adaptation as an adaptive statistical information design. Specifically, a case example is used to illustrate how challenging it is to plan a confirmatory adaptive statistical information

  14. Robust design of configurations and parameters of adaptable products

    NASA Astrophysics Data System (ADS)

    Zhang, Jian; Chen, Yongliang; Xue, Deyi; Gu, Peihua

    2014-03-01

    An adaptable product can satisfy different customer requirements by changing its configuration and parameter values during the operation stage. Design of adaptable products aims at reducing the environment impact through replacement of multiple different products with single adaptable ones. Due to the complex architecture, multiple functional requirements, and changes of product configurations and parameter values in operation, impact of uncertainties to the functional performance measures needs to be considered in design of adaptable products. In this paper, a robust design approach is introduced to identify the optimal design configuration and parameters of an adaptable product whose functional performance measures are the least sensitive to uncertainties. An adaptable product in this paper is modeled by both configurations and parameters. At the configuration level, methods to model different product configuration candidates in design and different product configuration states in operation to satisfy design requirements are introduced. At the parameter level, four types of product/operating parameters and relations among these parameters are discussed. A two-level optimization approach is developed to identify the optimal design configuration and its parameter values of the adaptable product. A case study is implemented to illustrate the effectiveness of the newly developed robust adaptable design method.

  15. Identification and Control of Aircrafts using Multiple Models and Adaptive Critics

    NASA Technical Reports Server (NTRS)

    Principe, Jose C.

    2007-01-01

    nutshell, the states of the reservoir of recurrent processing elements implement a projection space, where the desired response is optimally projected. This architecture trades training efficiency by a large increase in the dimension of the recurrent layer. However, the power of the recurrent neural networks can be brought to bear on practical difficult problems. Our goal was to implement an adaptive critic architecture implementing Bellman s approach to optimal control. However, we could only characterize the ESN performance as a critic in value function evaluation, which is just one of the pieces of the overall adaptive critic controller. The results were very convincing, and the simplicity of the implementation was unparalleled.

  16. Adaptive Design of Confirmatory Trials: Advances and Challenges

    PubMed Central

    Lai, Tze Leung; Lavori, Philip W.; Tsang, Ka Wai

    2015-01-01

    The past decade witnessed major developments in innovative designs of confirmatory clinical trials, and adaptive designs represent the most active area of these developments. We give an overview of the developments and associated statistical methods in several classes of adaptive designs of confirmatory trials. We also discuss their statistical difficulties and implementation challenges, and show how these problems are connected to other branches of mainstream Statistics, which we then apply to resolve the difficulties and bypass the bottlenecks in the development of adaptive designs for the next decade. PMID:26079372

  17. Creating a New Model for Mainstreaming Climate Change Adaptation for Critical Infrastructure: The New York City Climate Change Adaptation Task Force and the NYC Panel on Climate Change

    NASA Astrophysics Data System (ADS)

    Rosenzweig, C.; Solecki, W. D.; Freed, A. M.

    2008-12-01

    The New York City Climate Change Adaptation Task Force, launched in August 2008, aims to secure the city's critical infrastructure against rising seas, higher temperatures and fluctuating water supplies projected to result from climate change. The Climate Change Adaptation Task Force is part of PlaNYC, the city's long- term sustainability plan, and is composed of over 30 city and state agencies, public authorities and companies that operate the region's roads, bridges, tunnels, mass transit, and water, sewer, energy and telecommunications systems - all with critical infrastructure identified as vulnerable. It is one of the most comprehensive adaptation efforts yet launched by an urban region. To guide the effort, Mayor Michael Bloomberg has formed the New York City Panel on Climate Change (NPCC), modeled on the Intergovernmental Panel on Climate Change (IPCC). Experts on the panel include climatologists, sea-level rise specialists, adaptation experts, and engineers, as well as representatives from the insurance and legal sectors. The NPCC is developing planning tools for use by the Task Force members that provide information about climate risks, adaptation and risk assessment, prioritization frameworks, and climate protection levels. The advisory panel is supplying climate change projections, helping to identify at- risk infrastructure, and assisting the Task Force in developing adaptation strategies and guidelines for design of new structures. The NPCC will also publish an assessment report in 2009 that will serve as the foundation for climate change adaptation in the New York City region, similar to the IPCC reports. Issues that the Climate Change Adaptation Task Force and the NPCC are addressing include decision- making under climate change uncertainty, effective ways for expert knowledge to be incorporated into public actions, and strategies for maintaining consistent and effective attention to long-term climate change even as municipal governments cycle

  18. Application of Adaptive Autopilot Designs for an Unmanned Aerial Vehicle

    NASA Technical Reports Server (NTRS)

    Shin, Yoonghyun; Calise, Anthony J.; Motter, Mark A.

    2005-01-01

    This paper summarizes the application of two adaptive approaches to autopilot design, and presents an evaluation and comparison of the two approaches in simulation for an unmanned aerial vehicle. One approach employs two-stage dynamic inversion and the other employs feedback dynamic inversions based on a command augmentation system. Both are augmented with neural network based adaptive elements. The approaches permit adaptation to both parametric uncertainty and unmodeled dynamics, and incorporate a method that permits adaptation during periods of control saturation. Simulation results for an FQM-117B radio controlled miniature aerial vehicle are presented to illustrate the performance of the neural network based adaptation.

  19. Stimulating Critical Thinking through Faculty Development: Design, Evaluation, and Problems.

    ERIC Educational Resources Information Center

    Gibbs, Leonard E.; And Others

    A faculty development program designed to encourage critical thinking skills across the curriculum at the University of Wisconsin Eau Claire is described in this report. The program's goal was to stimulate faculty to add critical thinking to their pedagogical objectives. Faculty participants attended six 4-hour meetings designed to heighten their…

  20. Designing to Support Critical Engagement with Statistics

    ERIC Educational Resources Information Center

    Gresalfi, Melissa Sommerfeld

    2015-01-01

    The purpose of this paper is to describe a trajectory of designing for particular forms of engagement with mathematics. The forms of engagement that were targeted through these design experiments involved making intentional choices about which procedures to leverage in order to support particular claims (what I call "critical…

  1. Critical issues in cancer vaccine trial design.

    PubMed

    Clifton, Guy T; Kohrt, Holbrook E; Peoples, George E

    2015-12-16

    As the clinical experience with cancer vaccines and cancer immunotherapy increases, there are important lessons that can be learned from the successes and failures of past trials. Many lessons affect the design and conduct of clinical trials themselves. Appropriate patient selection, clinical trial design, immunologic monitoring, and appropriate endpoints are all essential to the efficiency and success of bringing cancer vaccines from conception to clinical use.

  2. Lessons Learned in Designing and Implementing a Computer-Adaptive Test for English

    ERIC Educational Resources Information Center

    Burston, Jack; Neophytou, Maro

    2014-01-01

    This paper describes the lessons learned in designing and implementing a computer-adaptive test (CAT) for English. The early identification of students with weak L2 English proficiency is of critical importance in university settings that have compulsory English language course graduation requirements. The most efficient means of diagnosing the L2…

  3. ROMPS critical design review data package

    NASA Technical Reports Server (NTRS)

    Dobbs, M. E.

    1992-01-01

    The design elements of the Robot-Operated Material Processing in Space (ROMPS) system are described in outline and graphical form. The following subsystems/topics are addressed: servo system, testbed and simulation results, System V Controller, robot module, furnace module, SCL experiment supervisor and script sample processing control, battery system, watchdog timers, mechanical/thermal considerations, and fault conditions and recovery.

  4. Critical Issues in Telecollaborative Task Design

    ERIC Educational Resources Information Center

    O'Dowd, R.; Waire, P.

    2009-01-01

    In this article we examine how instructors make decisions about task design in telecollaboration and the factors that influence these decisions during the actual implementation of the tasks. We begin with a review of the recent literature of online intercultural exchanges to identify and describe a typology of 12 different types of tasks and task…

  5. NASA's Space Launch System Marks Critical Design Review

    NASA Technical Reports Server (NTRS)

    Singer, Chris

    2016-01-01

    With completion of its Critical Design Review (CDR) in 2015, NASA is deep into the manufacturing and testing phases of its new Space Launch System (SLS) for beyond-Earth exploration. This CDR was the first in almost 40 years for a NASA human launch vehicle and marked another successful milestone on the road to the launch of a new era of deep space exploration. The review marked the 90-percent design-complete, a final look at the design and development plan of the integrated vehicle before full-scale fabrications begins and the prelude to the next milestone, design certification. Specifically, the review looked at the first of three increasingly capable configurations planned for SLS. This "Block I" design will stand 98.2 meters (m) (322 feet) tall and provide 39.1 million Newtons (8.8 million pounds) of thrust at liftoff to lift a payload of approximately 70 metric tons (154,000 pounds). This payload is more than double that of the retired space shuttle program or other current launch vehicles. It dramatically increases the mass and volume of human and robotic exploration. Additionally, it will decrease overall mission risk, increase safety, and simplify ground and mission operations - all significant considerations for crewed missions and unique, high-value national payloads. The Block 1 SLS will launch NASA's Orion Multi-Purpose Crew Vehicle (MPCV) on an uncrewed flight beyond the moon and back and the first crewed flight around the moon. The current design has a direct evolutionary path to a vehicle with a 130t lift capability that offers even more flexibility to reduce planetary trip times, simplify payload design cycles, and provide new capabilities such as planetary sample returns. Every major element of SLS has hardware in production or testing, including flight hardware for the Exploration 1 (EM-1) test flight. In fact, the SLS MPCV-to-Stage-Adapter (MSA) flew successfully on the Exploration Flight Test (EFT) 1 launch of a Delta IV and Orion spacecraft in

  6. The adaptive bleaching hypothesis: experimental tests of critical assumptions.

    PubMed

    Kinzie, R A; Takayama, M; Santos, S R; Coffroth, M A

    2001-02-01

    Coral bleaching, the loss of color due to loss of symbiotic zooxanthellae or their pigment, appears to be increasing in intensity and geographic extent, perhaps related to increasing sea surface temperatures. The adaptive bleaching hypothesis (ABH) posits that when environmental circumstances change, the loss of one or more kinds of zooxanthellae is rapidly, sometimes unnoticeably, followed by formation of a new symbiotic consortium with different zooxanthellae that are more suited to the new conditions in the host's habitat. Fundamental assumptions of the ABH include (1) different types of zooxanthellae respond differently to environmental conditions, specifically temperature, and (2) bleached adults can secondarily acquire zooxanthellae from the environment. We present simple tests of these assumptions and show that (1) genetically different strains of zooxanthellae exhibit different responses to elevated temperature, (2) bleached adult hosts can acquire algal symbionts with an apparently dose-dependent relationship between the concentration of zooxanthellae and the rate of establishment of the symbiosis, (3) and finally, bleached adult hosts can acquire symbionts from the water column.

  7. Multidimensional Adaptive Testing with Optimal Design Criteria for Item Selection

    ERIC Educational Resources Information Center

    Mulder, Joris; van der Linden, Wim J.

    2009-01-01

    Several criteria from the optimal design literature are examined for use with item selection in multidimensional adaptive testing. In particular, it is examined what criteria are appropriate for adaptive testing in which all abilities are intentional, some should be considered as a nuisance, or the interest is in the testing of a composite of the…

  8. 28. 'TOWER DESIGN NO. 11, ADAPTED FROM NO. 9,' drawn ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    28. 'TOWER DESIGN NO. 11, ADAPTED FROM NO. 9,' drawn by project architect Alfred Eichler, undated, ca. 1934. - Sacramento River Bridge, Spanning Sacramento River at California State Highway 275, Sacramento, Sacramento County, CA

  9. Program computes single-point failures in critical system designs

    NASA Technical Reports Server (NTRS)

    Brown, W. R.

    1967-01-01

    Computer program analyzes the designs of critical systems that will either prove the design is free of single-point failures or detect each member of the population of single-point failures inherent in a system design. This program should find application in the checkout of redundant circuits and digital systems.

  10. Topical Articles: A Course Designed to Improve Psychological Critical Thinking

    ERIC Educational Resources Information Center

    Penningroth, Suzanna L.; Despain, Laran H.; Gray, Matt J.

    2007-01-01

    The authors developed a one-credit freshman-level course designed to enhance psychological critical thinking. They based the new curriculum on Stanovich's (2004) text, with an emphasis on active learning and critically evaluating claims by applying scientific concepts. To assess the effectiveness of this course, they used a pretest-posttest design…

  11. From Ability to Action: Designing Instruction for Critical Thinking Dispositions.

    ERIC Educational Resources Information Center

    Leader, Lars F.; Middleton, James A.

    This paper explains the importance of disposition as an essential aspect of critical thinking and suggests how instruction can be designed to promote learners' development of the dispositional side of critical thinking. Topics addressed include: (1) the dispositional bottleneck between opportunity and action, i.e., sensitivity to occasion; (2)…

  12. 48 CFR 242.1105 - Assignment of criticality designator.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... clothing) under DoD 4140.1-R, DoD Materiel Management Regulation; and (ii) Ordinarily assign criticality designator C to unilateral purchase orders. (2) Only the contracting officer shall change the...

  13. 48 CFR 242.1105 - Assignment of criticality designator.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... clothing) under DoD 4140.1-R, DoD Materiel Management Regulation; and (ii) Ordinarily assign criticality designator C to unilateral purchase orders. (2) Only the contracting officer shall change the...

  14. 48 CFR 242.1105 - Assignment of criticality designator.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... clothing) under DoD 4140.1-R, DoD Materiel Management Regulation; and (ii) Ordinarily assign criticality designator C to unilateral purchase orders. (2) Only the contracting officer shall change the...

  15. Dynamics of adaptive structures: Design through simulations

    NASA Technical Reports Server (NTRS)

    Park, K. C.; Alexander, S.

    1993-01-01

    The use of a helical bi-morph actuator/sensor concept by mimicking the change of helical waveform in bacterial flagella is perhaps the first application of bacterial motions (living species) to longitudinal deployment of space structures. However, no dynamical considerations were analyzed to explain the waveform change mechanisms. The objective is to review various deployment concepts from the dynamics point of view and introduce the dynamical considerations from the outset as part of design considerations. Specifically, the impact of the incorporation of the combined static mechanisms and dynamic design considerations on the deployment performance during the reconfiguration stage is studied in terms of improved controllability, maneuvering duration, and joint singularity index. It is shown that intermediate configurations during articulations play an important role for improved joint mechanisms design and overall structural deployability.

  16. Designing for Change: Interoperability in a scaling and adapting environment

    NASA Astrophysics Data System (ADS)

    Yarmey, L.

    2015-12-01

    The Earth Science cyberinfrastructure landscape is constantly changing. Technologies advance and technical implementations are refined or replaced. Data types, volumes, packaging, and use cases evolve. Scientific requirements emerge and mature. Standards shift while systems scale and adapt. In this complex and dynamic environment, interoperability remains a critical component of successful cyberinfrastructure. Through the resource- and priority-driven iterations on systems, interfaces, and content, questions fundamental to stable and useful Earth Science cyberinfrastructure arise. For instance, how are sociotechnical changes planned, tracked, and communicated? How should operational stability balance against 'new and shiny'? How can ongoing maintenance and mitigation of technical debt be managed in an often short-term resource environment? The Arctic Data Explorer is a metadata brokering application developed to enable discovery of international, interdisciplinary Arctic data across distributed repositories. Completely dependent on interoperable third party systems, the Arctic Data Explorer publicly launched in 2013 with an original 3000+ data records from four Arctic repositories. Since then the search has scaled to 25,000+ data records from thirteen repositories at the time of writing. In the final months of original project funding, priorities shift to lean operations with a strategic eye on the future. Here we present lessons learned from four years of Arctic Data Explorer design, development, communication, and maintenance work along with remaining questions and potential directions.

  17. Jaguar critical habitat designation causes concern for Southwestern ranchers

    USGS Publications Warehouse

    Svancara, Colleen; Lien, Aaron M.; Vanasco, Wendy T.; Laura Lopez-Hoffman,; Ruyle, George B.

    2015-01-01

    The designation of jaguar critical habitat in April 2014 in southern Arizona and southwestern New Mexico created concern for livestock ranchers in the region. We interviewed ranchers to understand their concerns with the jaguar critical habitat designation and their attitudes toward jaguars, wildlife conservation, and resource management in general. Ranchers we interviewed were concerned about direct impacts of designated critical habitat on ranching, as well as possible alternative agendas of critical habitat advocates and issues specific to the borderlands region. The ranchers were less concerned about the presence of jaguars but were more concerned about possible limiting effects of the Endangered Species Act (ESA), distrust of government entities, and litigious environmental groups. To maximize effectiveness, government agencies should work to foster trust in the ranching community, be cognizant of sensitive issues specific to the region that may challenge endangered species conservation goals, recognize the opportunity to work with ranchers for endangered species management, and provide outreach about implications of the ESA.

  18. Adaptive two-stage designs in phase II clinical trials.

    PubMed

    Banerjee, Anindita; Tsiatis, Anastasios A

    2006-10-15

    Two-stage designs have been widely used in phase II clinical trials. Such designs are desirable because they allow a decision to be made on whether a treatment is effective or not after the accumulation of the data at the end of each stage. Optimal fixed two-stage designs, where the sample size at each stage is fixed in advance, were proposed by Simon when the primary outcome is a binary response. This paper proposes an adaptive two-stage design which allows the sample size at the second stage to depend on the results at the first stage. Using a Bayesian decision-theoretic construct, we derive optimal adaptive two-stage designs; the optimality criterion being minimum expected sample size under the null hypothesis. Comparisons are made between Simon's two-stage fixed design and the new design with respect to this optimality criterion. PMID:16479547

  19. ROMPS critical design review. Volume 3: Furnace module design documentation

    NASA Technical Reports Server (NTRS)

    Dobbs, M. E.

    1992-01-01

    As part of the furnace module design documentation, the furnace module Easylab programs definitions and command variables are described. Also included are Easylab commands flow charts and fault conditions.

  20. Designing Adaptive Low Dissipative High Order Schemes

    NASA Technical Reports Server (NTRS)

    Yee, H. C.; Sjoegreen, B.; Parks, John W. (Technical Monitor)

    2002-01-01

    Proper control of the numerical dissipation/filter to accurately resolve all relevant multiscales of complex flow problems while still maintaining nonlinear stability and efficiency for long-time numerical integrations poses a great challenge to the design of numerical methods. The required type and amount of numerical dissipation/filter are not only physical problem dependent, but also vary from one flow region to another. This is particularly true for unsteady high-speed shock/shear/boundary-layer/turbulence/acoustics interactions and/or combustion problems since the dynamics of the nonlinear effect of these flows are not well-understood. Even with extensive grid refinement, it is of paramount importance to have proper control on the type and amount of numerical dissipation/filter in regions where it is needed.

  1. Team-Centered Perspective for Adaptive Automation Design

    NASA Technical Reports Server (NTRS)

    Prinzel, Lawrence J., III

    2003-01-01

    Automation represents a very active area of human factors research. The journal, Human Factors, published a special issue on automation in 1985. Since then, hundreds of scientific studies have been published examining the nature of automation and its interaction with human performance. However, despite a dramatic increase in research investigating human factors issues in aviation automation, there remain areas that need further exploration. This NASA Technical Memorandum describes a new area of automation design and research, called adaptive automation. It discusses the concepts and outlines the human factors issues associated with the new method of adaptive function allocation. The primary focus is on human-centered design, and specifically on ensuring that adaptive automation is from a team-centered perspective. The document shows that adaptive automation has many human factors issues common to traditional automation design. Much like the introduction of other new technologies and paradigm shifts, adaptive automation presents an opportunity to remediate current problems but poses new ones for human-automation interaction in aerospace operations. The review here is intended to communicate the philosophical perspective and direction of adaptive automation research conducted under the Aerospace Operations Systems (AOS), Physiological and Psychological Stressors and Factors (PPSF) project.

  2. An Online Adaptive Learning Environment for Critical-Thinking-Infused English Literacy Instruction

    ERIC Educational Resources Information Center

    Yang, Ya-Ting Carolyn; Gamble, Jeffrey Hugh; Hung, Yu-Wan; Lin, Tzu-Yun

    2014-01-01

    Critical thinking (CT) and English literacy are two essential 21st century competencies that are a priority for teaching and learning in an increasingly digital learning environment. Taking advantage of innovations in educational technology, this study empirically investigates the effectiveness of CT-infused adaptive English literacy instruction…

  3. Spacecraft System Integration and Test: SSTI Lewis critical design audit

    NASA Technical Reports Server (NTRS)

    Brooks, R. P.; Cha, K. K.

    1995-01-01

    The Critical Design Audit package is the final detailed design package which provides a comprehensive description of the SSTI mission. This package includes the program overview, the system requirements, the science and applications activities, the ground segment development, the assembly, integration and test description, the payload and technology demonstrations, and the spacecraft bus subsystems. Publication and presentation of this document marks the final requirements and design freeze for SSTI.

  4. ROMPS critical design review. Volume 2: Robot module design documentation

    NASA Technical Reports Server (NTRS)

    Dobbs, M. E.

    1992-01-01

    The robot module design documentation for the Remote Operated Materials Processing in Space (ROMPS) experiment is compiled. This volume presents the following information: robot module modifications; Easylab commands definitions and flowcharts; Easylab program definitions and flowcharts; robot module fault conditions and structure charts; and C-DOC flow structure and cross references.

  5. The Potential of Adaptive Design in Animal Studies.

    PubMed

    Majid, Arshad; Bae, Ok-Nam; Redgrave, Jessica; Teare, Dawn; Ali, Ali; Zemke, Daniel

    2015-10-12

    Clinical trials are the backbone of medical research, and are often the last step in the development of new therapies for use in patients. Prior to human testing, however, preclinical studies using animal subjects are usually performed in order to provide initial data on the safety and effectiveness of prospective treatments. These studies can be costly and time consuming, and may also raise concerns about the ethical treatment of animals when potentially harmful procedures are involved. Adaptive design is a process by which the methods used in a study may be altered while it is being conducted in response to preliminary data or other new information. Adaptive design has been shown to be useful in reducing the time and costs associated with clinical trials, and may provide similar benefits in preclinical animal studies. The purpose of this review is to summarize various aspects of adaptive design and evaluate its potential for use in preclinical research.

  6. Failure of adaptive self-organized criticality during epileptic seizure attacks.

    PubMed

    Meisel, Christian; Storch, Alexander; Hallmeyer-Elgner, Susanne; Bullmore, Ed; Gross, Thilo

    2012-01-01

    Critical dynamics are assumed to be an attractive mode for normal brain functioning as information processing and computational capabilities are found to be optimal in the critical state. Recent experimental observations of neuronal activity patterns following power-law distributions, a hallmark of systems at a critical state, have led to the hypothesis that human brain dynamics could be poised at a phase transition between ordered and disordered activity. A so far unresolved question concerns the medical significance of critical brain activity and how it relates to pathological conditions. Using data from invasive electroencephalogram recordings from humans we show that during epileptic seizure attacks neuronal activity patterns deviate from the normally observed power-law distribution characterizing critical dynamics. The comparison of these observations to results from a computational model exhibiting self-organized criticality (SOC) based on adaptive networks allows further insights into the underlying dynamics. Together these results suggest that brain dynamics deviates from criticality during seizures caused by the failure of adaptive SOC.

  7. Adaptive critic design for computer intrusion detection system

    NASA Astrophysics Data System (ADS)

    Novokhodko, Alexander; Wunsch, Donald C., II; Dagli, Cihan H.

    2001-03-01

    This paper summarizes ongoing research. A neural network is used to detect a computer system intrusion basing on data from the system audit trail generated by Solaris Basic Security Module. The data have been provided by Lincoln Labs, MIT. The system alerts the human operator, when it encounters suspicious activity logged in the audit trail. To reduce the false alarm rate and accommodate the temporal indefiniteness of moment of attack a reinforcement learning approach is chosen to train the network.

  8. The design of digital-adaptive controllers for VTOL aircraft

    NASA Technical Reports Server (NTRS)

    Stengel, R. F.; Broussard, J. R.; Berry, P. W.

    1976-01-01

    Design procedures for VTOL automatic control systems have been developed and are presented. Using linear-optimal estimation and control techniques as a starting point, digital-adaptive control laws have been designed for the VALT Research Aircraft, a tandem-rotor helicopter which is equipped for fully automatic flight in terminal area operations. These control laws are designed to interface with velocity-command and attitude-command guidance logic, which could be used in short-haul VTOL operations. Developments reported here include new algorithms for designing non-zero-set-point digital regulators, design procedures for rate-limited systems, and algorithms for dynamic control trim setting.

  9. Missile guidance law design using adaptive cerebellar model articulation controller.

    PubMed

    Lin, Chih-Min; Peng, Ya-Fu

    2005-05-01

    An adaptive cerebellar model articulation controller (CMAC) is proposed for command to line-of-sight (CLOS) missile guidance law design. In this design, the three-dimensional (3-D) CLOS guidance problem is formulated as a tracking problem of a time-varying nonlinear system. The adaptive CMAC control system is comprised of a CMAC and a compensation controller. The CMAC control is used to imitate a feedback linearization control law and the compensation controller is utilized to compensate the difference between the feedback linearization control law and the CMAC control. The online adaptive law is derived based on the Lyapunov stability theorem to learn the weights of receptive-field basis functions in CMAC control. In addition, in order to relax the requirement of approximation error bound, an estimation law is derived to estimate the error bound. Then the adaptive CMAC control system is designed to achieve satisfactory tracking performance. Simulation results for different engagement scenarios illustrate the validity of the proposed adaptive CMAC-based guidance law.

  10. Experimental Design to Evaluate Directed Adaptive Mutation in Mammalian Cells

    PubMed Central

    Chiaro, Christopher R; May, Tobias

    2014-01-01

    Background We describe the experimental design for a methodological approach to determine whether directed adaptive mutation occurs in mammalian cells. Identification of directed adaptive mutation would have profound practical significance for a wide variety of biomedical problems, including disease development and resistance to treatment. In adaptive mutation, the genetic or epigenetic change is not random; instead, the presence and type of selection influences the frequency and character of the mutation event. Adaptive mutation can contribute to the evolution of microbial pathogenesis, cancer, and drug resistance, and may become a focus of novel therapeutic interventions. Objective Our experimental approach was designed to distinguish between 3 types of mutation: (1) random mutations that are independent of selective pressure, (2) undirected adaptive mutations that arise when selective pressure induces a general increase in the mutation rate, and (3) directed adaptive mutations that arise when selective pressure induces targeted mutations that specifically influence the adaptive response. The purpose of this report is to introduce an experimental design and describe limited pilot experiment data (not to describe a complete set of experiments); hence, it is an early report. Methods An experimental design based on immortalization of mouse embryonic fibroblast cells is presented that links clonal cell growth to reversal of an inactivating polyadenylation site mutation. Thus, cells exhibit growth only in the presence of both the countermutation and an inducing agent (doxycycline). The type and frequency of mutation in the presence or absence of doxycycline will be evaluated. Additional experimental approaches would determine whether the cells exhibit a generalized increase in mutation rate and/or whether the cells show altered expression of error-prone DNA polymerases or of mismatch repair proteins. Results We performed the initial stages of characterizing our system

  11. 78 FR 46563 - Endangered and Threatened Species: Proposed Rule To Designate Critical Habitat for the Northwest...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-01

    ... Species: Proposed Rule To Designate Critical Habitat for the Northwest Atlantic Ocean Loggerhead Sea... Designate Critical Habitat for the Northwest Atlantic Ocean Loggerhead Sea Turtle Distinct Population... proposes designation of critical habitat for the threatened Northwest Atlantic Ocean Distinct...

  12. The Adaptive Physical Education Program: Its Design and Curriculum.

    ERIC Educational Resources Information Center

    Henn, Joan M.

    The booklet describes a program designed to improve the play skills of seriously disturbed, multiply handicapped children (5 to 13 years old) through gross motor skill development. A six step process is described for the adaptive physical education program: assessment, development of interdisciplinary goals, interventions, development of goals for…

  13. Adaptive multibeam phased array design for a Spacelab experiment

    NASA Technical Reports Server (NTRS)

    Noji, T. T.; Fass, S.; Fuoco, A. M.; Wang, C. D.

    1977-01-01

    The parametric tradeoff analyses and design for an Adaptive Multibeam Phased Array (AMPA) for a Spacelab experiment are described. This AMPA Experiment System was designed with particular emphasis to maximize channel capacity and minimize implementation and cost impacts for future austere maritime and aeronautical users, operating with a low gain hemispherical coverage antenna element, low effective radiated power, and low antenna gain-to-system noise temperature ratio.

  14. Preliminary Report on Mission Design and Operations for Critical Events

    NASA Technical Reports Server (NTRS)

    Hayden, Sandra C.; Tumer, Irem

    2005-01-01

    Mission-critical events are defined in the Jet Propulsion Laboratory s Flight Project Practices as those sequences of events which must succeed in order to attain mission goals. These are dependent on the particular operational concept and design reference mission, and are especially important when committing to irreversible events. Critical events include main engine cutoff (MECO) after launch; engine cutoff or parachute deployment on entry, descent, and landing (EDL); orbital insertion; separation of payload from vehicle or separation of booster segments; maintenance of pointing accuracy for power and communication; and deployment of solar arrays and communication antennas. The purpose of this paper is to report on the current practices in handling mission-critical events in design and operations at major NASA spaceflight centers. The scope of this report includes NASA Johnson Space Center (JSC), NASA Goddard Space Flight Center (GSFC), and NASA Jet Propulsion Laboratory (JPL), with staff at each center consulted on their current practices, processes, and procedures.

  15. [Introduction to critical reading of articles: study design and biases].

    PubMed

    García Villar, C

    2015-01-01

    The critical evaluation of an article enables professionals to make good use of the new information and therefore has direct repercussions for the benefit of our patients. Before undertaking a detailed critical reading of the chosen article, we need to consider whether the study used the most appropriate design for the question it aimed to answer (i.e., whether the level of evidence is adequate). To do this, we need to know how to classify studies in function of their design (descriptive or analytical; prospective or retrospective; cross-sectional or longitudinal) as well as their correlation with the levels of evidence. In critical reading it is also important to know the main systematic errors or biases that can affect a study. Biases can appear in any phase of a study; they can affect the sample, the development of the study, or the measurement of the results.

  16. [Introduction to critical reading of articles: study design and biases].

    PubMed

    García Villar, C

    2015-01-01

    The critical evaluation of an article enables professionals to make good use of the new information and therefore has direct repercussions for the benefit of our patients. Before undertaking a detailed critical reading of the chosen article, we need to consider whether the study used the most appropriate design for the question it aimed to answer (i.e., whether the level of evidence is adequate). To do this, we need to know how to classify studies in function of their design (descriptive or analytical; prospective or retrospective; cross-sectional or longitudinal) as well as their correlation with the levels of evidence. In critical reading it is also important to know the main systematic errors or biases that can affect a study. Biases can appear in any phase of a study; they can affect the sample, the development of the study, or the measurement of the results. PMID:25458123

  17. Critical Features of Engineering Design in Technology Education

    ERIC Educational Resources Information Center

    Asunda, Paul A.; Hill, Roger B.

    2007-01-01

    The purpose of this study was to find critical features of engineering design that can be incorporated within technology education learning activities, and develop a rubric for assessing these features. Data were collected through semi-structured interviews with three professors actively involved in engineering education. Supporting documents such…

  18. Flexible design of two-stage adaptive procedures for phase III clinical trials.

    PubMed

    Koyama, Tatsuki

    2007-07-01

    The recent popularity of two-stage adaptive designs has fueled a number of proposals for their use in phase III clinical trials. Many of these designs assign certain restrictive functional forms to the design elements of stage 2, such as sample size, critical value and conditional power functions. We propose a more flexible method of design without imposing any particular functional forms on these design elements. Our methodology permits specification of a design based on either conditional or unconditional characteristics, and allows accommodation of sample size limit. Furthermore, we show how to compute the P value, confidence interval and a reasonable point estimate for any design that can be placed under the proposed framework. PMID:17307399

  19. Individually designed PALs vs. power optimized PALs adaptation comparison.

    PubMed

    Muždalo, Nataša Vujko; Mihelčič, Matjaž

    2015-03-01

    The practice shows that in everyday life we encounter ever-growing demand for better visual acuity at all viewing distances. The presbyopic population needs correction to far, near and intermediate distance with different dioptric powers. PAL lenses seem to be a comfortable solution. The object of the present study is the analysis of the factors determining adaptation to progressive addition lenses (PAL) of the first-time users. Only novice test persons were chosen in order to avoid the bias of previously worn particular lens design. For optimal results with this type of lens, several individual parameters must be considered: correct refraction, precise ocular and facial measures, and proper mounting of lenses into the frame. Nevertheless, first time wearers encounter various difficulties in the process of adapting to this type of glasses and adaptation time differs greatly between individual users. The question that arises is how much the individual parameters really affect the ease of adaptation and comfort when wearing progressive glasses. To clarify this, in the present study, the individual PAL lenses--Rodenstock's Impression FreeSign (with inclusion of all parameters related to the user's eye and spectacle frame: prescription, pupillary distance, fitting height, back vertex distance, pantoscopic angle and curvature of the frame) were compared to power optimized PAL--Rodenstock's Multigressiv MyView (respecting only prescription power and pupillary distance). Adaptation process was monitored over a period of four weeks. The collected results represent scores of user's subjective impressions, where the users themselves rated their adaptation to new progressive glasses and the degree of subjective visual impression. The results show that adaptation time to fully individually fit PAL is easier and quickly. The information obtained from users is valuable in everyday optometry practice because along with the manufacturer's specifications, the user's experience can

  20. Individually designed PALs vs. power optimized PALs adaptation comparison.

    PubMed

    Muždalo, Nataša Vujko; Mihelčič, Matjaž

    2015-03-01

    The practice shows that in everyday life we encounter ever-growing demand for better visual acuity at all viewing distances. The presbyopic population needs correction to far, near and intermediate distance with different dioptric powers. PAL lenses seem to be a comfortable solution. The object of the present study is the analysis of the factors determining adaptation to progressive addition lenses (PAL) of the first-time users. Only novice test persons were chosen in order to avoid the bias of previously worn particular lens design. For optimal results with this type of lens, several individual parameters must be considered: correct refraction, precise ocular and facial measures, and proper mounting of lenses into the frame. Nevertheless, first time wearers encounter various difficulties in the process of adapting to this type of glasses and adaptation time differs greatly between individual users. The question that arises is how much the individual parameters really affect the ease of adaptation and comfort when wearing progressive glasses. To clarify this, in the present study, the individual PAL lenses--Rodenstock's Impression FreeSign (with inclusion of all parameters related to the user's eye and spectacle frame: prescription, pupillary distance, fitting height, back vertex distance, pantoscopic angle and curvature of the frame) were compared to power optimized PAL--Rodenstock's Multigressiv MyView (respecting only prescription power and pupillary distance). Adaptation process was monitored over a period of four weeks. The collected results represent scores of user's subjective impressions, where the users themselves rated their adaptation to new progressive glasses and the degree of subjective visual impression. The results show that adaptation time to fully individually fit PAL is easier and quickly. The information obtained from users is valuable in everyday optometry practice because along with the manufacturer's specifications, the user's experience can

  1. Breckinridge Project, initial effort. Report XI, Volume IV. Critical review of the design basis. [Critical review

    SciTech Connect

    1981-05-01

    Report XI, Technical Audit, is a compendium of research material used during the Initial Effort in making engineering comparisons and decisions. Volumes 4 and 5 of Report XI present those studies which provide a Critical Review of the Design Basis. The Critical Review Report, prepared by Intercontinental Econergy Associates, Inc., summarizes findings from an extensive review of the data base for the H-Coal process design. Volume 4 presents this review and assessment, and includes supporting material; specifically, Design Data Tabulation (Appendix A), Process Flow Sheets (Appendix B), and References (Appendix C). Volume 5 is a continuation of the references of Appendix C. Studies of a proprietary nature are noted and referenced, but are not included in these volumes. They are included in the Limited Access versions of these reports and may be reviewed by properly cleared personnel in the offices of Ashland Synthetic Fuels, Inc.

  2. Breckinridge Project, initial effort. Report XI, Volume V. Critical review of the design basis. [Critical review

    SciTech Connect

    1982-01-01

    Report XI, Technical Audit, is a compendium of research material used during the Initial Effort in making engineering comparisons and decisions. Volumes 4 and 5 of Report XI present those studies which provide a Critical Review of the Design Basis. The Critical Review Report, prepared by Intercontinental Econergy Associates, Inc., summarizes findings from an extensive review of the data base for the H-Coal process design. Volume 4 presents this review and assessment, and includes supporting material; specifically, Design Data Tabulation (Appendix A), Process Flow Sheets (Appendix B), and References (Appendix C). Volume 5 is a continuation of the references of Appendix C. Studies of a proprietary nature are noted and referenced, but are not included in these volumes. They are included in the Limited Access versions of these reports and may be reviewed by properly cleared personnel in the offices of Ashland Synthetic Fuels, Inc.

  3. An information theoretic approach of designing sparse kernel adaptive filters.

    PubMed

    Liu, Weifeng; Park, Il; Principe, José C

    2009-12-01

    This paper discusses an information theoretic approach of designing sparse kernel adaptive filters. To determine useful data to be learned and remove redundant ones, a subjective information measure called surprise is introduced. Surprise captures the amount of information a datum contains which is transferable to a learning system. Based on this concept, we propose a systematic sparsification scheme, which can drastically reduce the time and space complexity without harming the performance of kernel adaptive filters. Nonlinear regression, short term chaotic time-series prediction, and long term time-series forecasting examples are presented. PMID:19923047

  4. An information theoretic approach of designing sparse kernel adaptive filters.

    PubMed

    Liu, Weifeng; Park, Il; Principe, José C

    2009-12-01

    This paper discusses an information theoretic approach of designing sparse kernel adaptive filters. To determine useful data to be learned and remove redundant ones, a subjective information measure called surprise is introduced. Surprise captures the amount of information a datum contains which is transferable to a learning system. Based on this concept, we propose a systematic sparsification scheme, which can drastically reduce the time and space complexity without harming the performance of kernel adaptive filters. Nonlinear regression, short term chaotic time-series prediction, and long term time-series forecasting examples are presented.

  5. Covariate-adjusted response-adaptive designs for binary response.

    PubMed

    Rosenberger, W F; Vidyashankar, A N; Agarwal, D K

    2001-11-01

    An adaptive allocation design for phase III clinical trials that incorporates covariates is described. The allocation scheme maps the covariate-adjusted odds ratio from a logistic regression model onto [0, 1]. Simulations assume that both staggered entry and time to response are random and follow a known probability distribution that can depend on the treatment assigned, the patient's response, a covariate, or a time trend. Confidence intervals on the covariate-adjusted odds ratio is slightly anticonservative for the adaptive design under the null hypothesis, but power is similar to equal allocation under various alternatives for n = 200. For similar power, the net savings in terms of expected number of treatment failures is modest, but enough to make this design attractive for certain studies where known covariates are expected to be important and stratification is not desired, and treatment failures have a high ethical cost.

  6. Design of scheduling and rate-adaptation algorithms for adaptive HTTP streaming

    NASA Astrophysics Data System (ADS)

    Hesse, Stephan

    2013-09-01

    In adaptive HTTP streaming model, the HTTP server stores multiple representations of media content, encoded at different rates. It is the function of a streaming client to select and retrieve segments of appropriate representations to enable continuous media playback under varying network conditions. In this paper we describe design of a control mechanism enabling such a selection and retrieval of media data during streaming session. We also describe the architecture of a streaming client for adaptive HTTP streaming and provide simulation data illustrating the effectiveness of the proposed control mechanism for handling bandwidth fluctuations typical for TCP traffic.

  7. A Time-Critical Adaptive Approach for Visualizing Natural Scenes on Different Devices

    PubMed Central

    Dong, Tianyang; Liu, Siyuan; Xia, Jiajia; Fan, Jing; Zhang, Ling

    2015-01-01

    To automatically adapt to various hardware and software environments on different devices, this paper presents a time-critical adaptive approach for visualizing natural scenes. In this method, a simplified expression of a tree model is used for different devices. The best rendering scheme is intelligently selected to generate a particular scene by estimating the rendering time of trees based on their visual importance. Therefore, this approach can ensure the reality of natural scenes while maintaining a constant frame rate for their interactive display. To verify its effectiveness and flexibility, this method is applied in different devices, such as a desktop computer, laptop, iPad and smart phone. Applications show that the method proposed in this paper can not only adapt to devices with different computing abilities and system resources very well but can also achieve rather good visual realism and a constant frame rate for natural scenes. PMID:25723177

  8. Design of an adaptive neural network based power system stabilizer.

    PubMed

    Liu, Wenxin; Venayagamoorthy, Ganesh K; Wunsch, Donald C

    2003-01-01

    Power system stabilizers (PSS) are used to generate supplementary control signals for the excitation system in order to damp the low frequency power system oscillations. To overcome the drawbacks of conventional PSS (CPSS), numerous techniques have been proposed in the literature. Based on the analysis of existing techniques, this paper presents an indirect adaptive neural network based power system stabilizer (IDNC) design. The proposed IDNC consists of a neuro-controller, which is used to generate a supplementary control signal to the excitation system, and a neuro-identifier, which is used to model the dynamics of the power system and to adapt the neuro-controller parameters. The proposed method has the features of a simple structure, adaptivity and fast response. The proposed IDNC is evaluated on a single machine infinite bus power system under different operating conditions and disturbances to demonstrate its effectiveness and robustness. PMID:12850048

  9. Design of smart composite platforms for adaptive trust vector control and adaptive laser telescope for satellite applications

    NASA Astrophysics Data System (ADS)

    Ghasemi-Nejhad, Mehrdad N.

    2013-04-01

    designed to have tip-tilt pointing and simultaneous multi-degree-of-freedom vibration isolation capability for pointing stabilization. Analytical approaches have been employed for determining the loads in the components as well as optimizing the design of the system. The different critical components such as telescope tube struts, flexure joints, and the secondary mirror mount have been designed and analyzed using finite element technique. The Simultaneous Precision Positioning and Vibration Suppression (SPPVS) smart composites platforms for the adaptive TVC and adaptive composite telescope are analogous (e.g., see work by Ghasemi-Nejhad and co-workers [1, 2]), where innovative concepts and control strategies are introduced, and experimental verifications of simultaneous thrust vector control and vibration isolation of satellites were performed. The smart composite platforms function as an active structural interface between the main thruster of a satellite and the satellite structure for the adaptive TVC application and as an active structural interface between the main smart composite telescope and the satellite structure for the adaptive laser communication application. The cascaded multiple feedback loops compensate the hysteresis (for piezoelectric stacks inside the three linear actuators that individually have simultaneous precision positioning and vibration suppression), dead-zone, back-lash, and friction nonlinearities very well, and provide precision and quick smart platform control and satisfactory thrust vector control capability. In addition, for example for the adaptive TVC, the experimental results show that the smart composite platform satisfactorily provided precision and fast smart platform control as well as the satisfactory thrust vector control capability. The vibration controller isolated 97% of the vibration energy due to the thruster firing.

  10. Design of Adaptive Policy Pathways under Deep Uncertainties

    NASA Astrophysics Data System (ADS)

    Babovic, Vladan

    2013-04-01

    The design of large-scale engineering and infrastructural systems today is growing in complexity. Designers need to consider sociotechnical uncertainties, intricacies, and processes in the long- term strategic deployment and operations of these systems. In this context, water and spatial management is increasingly challenged not only by climate-associated changes such as sea level rise and increased spatio-temporal variability of precipitation, but also by pressures due to population growth and particularly accelerating rate of urbanisation. Furthermore, high investment costs and long term-nature of water-related infrastructure projects requires long-term planning perspective, sometimes extending over many decades. Adaptation to such changes is not only determined by what is known or anticipated at present, but also by what will be experienced and learned as the future unfolds, as well as by policy responses to social and water events. As a result, a pathway emerges. Instead of responding to 'surprises' and making decisions on ad hoc basis, exploring adaptation pathways into the future provide indispensable support in water management decision-making. In this contribution, a structured approach for designing a dynamic adaptive policy based on the concepts of adaptive policy making and adaptation pathways is introduced. Such an approach provides flexibility which allows change over time in response to how the future unfolds, what is learned about the system, and changes in societal preferences. The introduced flexibility provides means for dealing with complexities of adaptation under deep uncertainties. It enables engineering systems to change in the face of uncertainty to reduce impacts from downside scenarios while capitalizing on upside opportunities. This contribution presents comprehensive framework for development and deployment of adaptive policy pathway framework, and demonstrates its performance under deep uncertainties on a case study related to urban

  11. Adaptive Designs for Randomized Trials in Public Health

    PubMed Central

    Brown, C. Hendricks; Have, Thomas R. Ten; Jo, Booil; Dagne, Getachew; Wyman, Peter A.; Muthén, Bengt; Gibbons, Robert D.

    2009-01-01

    In this article, we present a discussion of two general ways in which the traditional randomized trial can be modified or adapted in response to the data being collected. We use the term adaptive design to refer to a trial in which characteristics of the study itself, such as the proportion assigned to active intervention versus control, change during the trial in response to data being collected. The term adaptive sequence of trials refers to a decision-making process that fundamentally informs the conceptualization and conduct of each new trial with the results of previous trials. Our discussion below investigates the utility of these two types of adaptations for public health evaluations. Examples are provided to illustrate how adaptation can be used in practice. From these case studies, we discuss whether such evaluations can or should be analyzed as if they were formal randomized trials, and we discuss practical as well as ethical issues arising in the conduct of these new-generation trials. PMID:19296774

  12. Adaptive critic neural network-based object grasping control using a three-finger gripper.

    PubMed

    Jagannathan, S; Galan, Gustavo

    2004-03-01

    Grasping of objects has been a challenging task for robots. The complex grasping task can be defined as object contact control and manipulation subtasks. In this paper, object contact control subtask is defined as the ability to follow a trajectory accurately by the fingers of a gripper. The object manipulation subtask is defined in terms of maintaining a predefined applied force by the fingers on the object. A sophisticated controller is necessary since the process of grasping an object without a priori knowledge of the object's size, texture, softness, gripper, and contact dynamics is rather difficult. Moreover, the object has to be secured accurately and considerably fast without damaging it. Since the gripper, contact dynamics, and the object properties are not typically known beforehand, an adaptive critic neural network (NN)-based hybrid position/force control scheme is introduced. The feedforward action generating NN in the adaptive critic NN controller compensates the nonlinear gripper and contact dynamics. The learning of the action generating NN is performed on-line based on a critic NN output signal. The controller ensures that a three-finger gripper tracks a desired trajectory while applying desired forces on the object for manipulation. Novel NN weight tuning updates are derived for the action generating and critic NNs so that Lyapunov-based stability analysis can be shown. Simulation results demonstrate that the proposed scheme successfully allows fingers of a gripper to secure objects without the knowledge of the underlying gripper and contact dynamics of the object compared to conventional schemes.

  13. Adaptation of the Critical Care Family Need Inventory to the Turkish population and its psychometric properties.

    PubMed

    Büyükçoban, Sibel; Çiçeklioğlu, Meltem; Demiral Yılmaz, Nilüfer; Civaner, M Murat

    2015-01-01

    In the complex environment of intensive care units, needs of patients' relatives might be seen as the lowest priority. On the other hand, because of their patients' critical and often uncertain conditions, stress levels of relatives are quite high. This study aims to adapt the Critical Care Family Need Inventory, which assesses the needs of patients' relatives, for use with the Turkish-speaking population and to assess psychometric properties of the resulting inventory. The study was conducted in a state hospital with the participation of 191 critical care patient relatives. Content validity was assessed by expert opinions, and construct validity was examined by exploratory factor analysis (EFA). Cronbach's alpha coefficient was used to determine internal consistency. The translated inventory has a content validity ratio higher than the minimum acceptable level. Its construct validity was established by the EFA. Cronbach's alpha coefficient for the entire scale was 0.93 and higher than 0.80 for subscales, thus demonstrating the translated version's reliability. The Turkish adaptation appropriately reflects all dimensions of needs in the original CCFNI, and its psychometric properties were acceptable. The revised tool could be useful for helping critical care healthcare workers provide services in a holistic approach and for policymakers to improve quality of service. PMID:26357593

  14. Self-Adaptive Stepsize Search Applied to Optimal Structural Design

    NASA Astrophysics Data System (ADS)

    Nolle, L.; Bland, J. A.

    Structural engineering often involves the design of space frames that are required to resist predefined external forces without exhibiting plastic deformation. The weight of the structure and hence the weight of its constituent members has to be as low as possible for economical reasons without violating any of the load constraints. Design spaces are usually vast and the computational costs for analyzing a single design are usually high. Therefore, not every possible design can be evaluated for real-world problems. In this work, a standard structural design problem, the 25-bar problem, has been solved using self-adaptive stepsize search (SASS), a relatively new search heuristic. This algorithm has only one control parameter and therefore overcomes the drawback of modern search heuristics, i.e. the need to first find a set of optimum control parameter settings for the problem at hand. In this work, SASS outperforms simulated-annealing, genetic algorithms, tabu search and ant colony optimization.

  15. Pedagogical Challenges and Possibilities: Adapting Critical Literacy in EFL College Writing Using a Video-Authoring Project

    ERIC Educational Resources Information Center

    Park, Sunyoung

    2010-01-01

    This thesis is a critical action research to explore the pedagogical challenges and possibilities by adapting a critical literacy in an EFL college writing class supported by a video-authoring project. Mainly, it focuses on three parts of the study; 1) How will develop the theoretical notions of a critical literacy in an EFL classroom, in…

  16. Space Station Freedom - Approaching the critical design phase

    NASA Technical Reports Server (NTRS)

    Kohrs, Richard H.; Huckins, Earle, III

    1992-01-01

    The status and future developments of the Space Station Freedom are discussed. To date detailed design drawings are being produced to manufacture SSF hardware. A critical design review (CDR) for the man-tended capability configuration is planned to be performed in 1993 under the SSF program. The main objective of the CDR is to enable the program to make a full commitment to proceed to manufacture parts and assemblies. NASA recently signed a contract with the Russian space company, NPO Energia, to evaluate potential applications of various Russian space hardware for on-going NASA programs.

  17. Optimal Bayesian Adaptive Design for Test-Item Calibration.

    PubMed

    van der Linden, Wim J; Ren, Hao

    2015-06-01

    An optimal adaptive design for test-item calibration based on Bayesian optimality criteria is presented. The design adapts the choice of field-test items to the examinees taking an operational adaptive test using both the information in the posterior distributions of their ability parameters and the current posterior distributions of the field-test parameters. Different criteria of optimality based on the two types of posterior distributions are possible. The design can be implemented using an MCMC scheme with alternating stages of sampling from the posterior distributions of the test takers' ability parameters and the parameters of the field-test items while reusing samples from earlier posterior distributions of the other parameters. Results from a simulation study demonstrated the feasibility of the proposed MCMC implementation for operational item calibration. A comparison of performances for different optimality criteria showed faster calibration of substantial numbers of items for the criterion of D-optimality relative to A-optimality, a special case of c-optimality, and random assignment of items to the test takers.

  18. Critical Incident Stress Management (CISM) in complex systems: cultural adaptation and safety impacts in healthcare.

    PubMed

    Müller-Leonhardt, Alice; Mitchell, Shannon G; Vogt, Joachim; Schürmann, Tim

    2014-07-01

    In complex systems, such as hospitals or air traffic control operations, critical incidents (CIs) are unavoidable. These incidents can not only become critical for victims but also for professionals working at the "sharp end" who may have to deal with critical incident stress (CIS) reactions that may be severe and impede emotional, physical, cognitive and social functioning. These CIS reactions may occur not only under exceptional conditions but also during every-day work and become an important safety issue. In contrast to air traffic management (ATM) operations in Europe, which have readily adopted critical incident stress management (CISM), most hospitals have not yet implemented comprehensive peer support programs. This survey was conducted in 2010 at the only European general hospital setting which implemented CISM program since 2004. The aim of the article is to describe possible contribution of CISM in hospital settings framed from the perspective of organizational safety and individual health for healthcare professionals. Findings affirm that daily work related incidents also can become critical for healthcare professionals. Program efficiency appears to be influenced by the professional culture, as well as organizational structure and policies. Overall, findings demonstrate that the adaptation of the CISM program in general hospitals takes time but, once established, it may serve as a mechanism for changing professional culture, thereby permitting the framing of even small incidents or near misses as an opportunity to provide valuable feedback to the system.

  19. The VIADUC project: innovation in climate adaptation through service design

    NASA Astrophysics Data System (ADS)

    Corre, L.; Dandin, P.; L'Hôte, D.; Besson, F.

    2015-07-01

    From the French National Adaptation to Climate Change Plan, the "Drias, les futurs du climat" service has been developed to provide easy access to French regional climate projections. This is a major step for the implementation of French Climate Services. The usefulness of this service for the end-users and decision makers involved with adaptation planning at a local scale is investigated. As such, the VIADUC project is: to evaluate and enhance Drias, as well as to imagine future development in support of adaptation. Climate scientists work together with end-users and a service designer. The designer's role is to propose an innovative approach based on the interaction between scientists and citizens. The chosen end-users are three Natural Regional Parks located in the South West of France. The latter parks are administrative entities which gather municipalities having a common natural and cultural heritage. They are also rural areas in which specific economic activities take place, and therefore are concerned and involved in both protecting their environment and setting-up sustainable economic development. The first year of the project has been dedicated to investigation including the questioning of relevant representatives. Three key local economic sectors have been selected: i.e. forestry, pastoral farming and building activities. Working groups were composed of technicians, administrative and maintenance staff, policy makers and climate researchers. The sectors' needs for climate information have been assessed. The lessons learned led to actions which are presented hereinafter.

  20. Hybrid Computerized Adaptive Testing: From Group Sequential Design to Fully Sequential Design

    ERIC Educational Resources Information Center

    Wang, Shiyu; Lin, Haiyan; Chang, Hua-Hua; Douglas, Jeff

    2016-01-01

    Computerized adaptive testing (CAT) and multistage testing (MST) have become two of the most popular modes in large-scale computer-based sequential testing. Though most designs of CAT and MST exhibit strength and weakness in recent large-scale implementations, there is no simple answer to the question of which design is better because different…

  1. Design Process of Flight Vehicle Structures for a Common Bulkhead and an MPCV Spacecraft Adapter

    NASA Technical Reports Server (NTRS)

    Aggarwal, Pravin; Hull, Patrick V.

    2015-01-01

    Design and manufacturing space flight vehicle structures is a skillset that has grown considerably at NASA during that last several years. Beginning with the Ares program and followed by the Space Launch System (SLS); in-house designs were produced for both the Upper Stage and the SLS Multipurpose crew vehicle (MPCV) spacecraft adapter. Specifically, critical design review (CDR) level analysis and flight production drawing were produced for the above mentioned hardware. In particular, the experience of this in-house design work led to increased manufacturing infrastructure for both Marshal Space Flight Center (MSFC) and Michoud Assembly Facility (MAF), improved skillsets in both analysis and design, and hands on experience in building and testing (MSA) full scale hardware. The hardware design and development processes from initiation to CDR and finally flight; resulted in many challenges and experiences that produced valuable lessons. This paper builds on these experiences of NASA in recent years on designing and fabricating flight hardware and examines the design/development processes used, as well as the challenges and lessons learned, i.e. from the initial design, loads estimation and mass constraints to structural optimization/affordability to release of production drawing to hardware manufacturing. While there are many documented design processes which a design engineer can follow, these unique experiences can offer insight into designing hardware in current program environments and present solutions to many of the challenges experienced by the engineering team.

  2. Reflections on the Adaptive Designs Accelerating Promising Trials Into Treatments (ADAPT-IT) Process—Findings from a Qualitative Study

    PubMed Central

    Guetterman, Timothy C.; Fetters, Michael D.; Legocki, Laurie J.; Mawocha, Samkeliso; Barsan, William G.; Lewis, Roger J.; Berry, Donald A.; Meurer, William J.

    2015-01-01

    Context The context for this study was the Adaptive Designs Advancing Promising Treatments Into Trials (ADAPT-IT) project, which aimed to incorporate flexible adaptive designs into pivotal clinical trials and to conduct an assessment of the trial development process. Little research provides guidance to academic institutions in planning adaptive trials. Objectives The purpose of this qualitative study was to explore the perspectives and experiences of stakeholders as they reflected back about the interactive ADAPT-IT adaptive design development process, and to understand their perspectives regarding lessons learned about the design of the trials and trial development. Materials and methods We conducted semi-structured interviews with ten key stakeholders and observations of the process. We employed qualitative thematic text data analysis to reduce the data into themes about the ADAPT-IT project and adaptive clinical trials. Results The qualitative analysis revealed four themes: education of the project participants, how the process evolved with participant feedback, procedures that could enhance the development of other trials, and education of the broader research community. Discussion and conclusions While participants became more likely to consider flexible adaptive designs, additional education is needed to both understand the adaptive methodology and articulate it when planning trials. PMID:26622163

  3. Task-oriented quality assessment and adaptation in real-time mission critical video streaming applications

    NASA Astrophysics Data System (ADS)

    Nightingale, James; Wang, Qi; Grecos, Christos

    2015-02-01

    In recent years video traffic has become the dominant application on the Internet with global year-on-year increases in video-oriented consumer services. Driven by improved bandwidth in both mobile and fixed networks, steadily reducing hardware costs and the development of new technologies, many existing and new classes of commercial and industrial video applications are now being upgraded or emerging. Some of the use cases for these applications include areas such as public and private security monitoring for loss prevention or intruder detection, industrial process monitoring and critical infrastructure monitoring. The use of video is becoming commonplace in defence, security, commercial, industrial, educational and health contexts. Towards optimal performances, the design or optimisation in each of these applications should be context aware and task oriented with the characteristics of the video stream (frame rate, spatial resolution, bandwidth etc.) chosen to match the use case requirements. For example, in the security domain, a task-oriented consideration may be that higher resolution video would be required to identify an intruder than to simply detect his presence. Whilst in the same case, contextual factors such as the requirement to transmit over a resource-limited wireless link, may impose constraints on the selection of optimum task-oriented parameters. This paper presents a novel, conceptually simple and easily implemented method of assessing video quality relative to its suitability for a particular task and dynamically adapting videos streams during transmission to ensure that the task can be successfully completed. Firstly we defined two principle classes of tasks: recognition tasks and event detection tasks. These task classes are further subdivided into a set of task-related profiles, each of which is associated with a set of taskoriented attributes (minimum spatial resolution, minimum frame rate etc.). For example, in the detection class

  4. The Adaptation of East Asian Masters Students to Western Norms of Critical Thinking and Argumentation in the UK

    ERIC Educational Resources Information Center

    Durkin, Kathy

    2008-01-01

    The paper explores the adaptation experiences of East Asian masters students in the UK in dealing with western academic norms of critical thinking and debate. Through in-depth interviewing, students' perceptions of their learning experiences were explored, and stages in this adaptation process were identified, with various entry and exit routes.…

  5. Adaptive optoelectronic camouflage systems with designs inspired by cephalopod skins

    PubMed Central

    Yu, Cunjiang; Li, Yuhang; Zhang, Xun; Huang, Xian; Malyarchuk, Viktor; Wang, Shuodao; Shi, Yan; Gao, Li; Su, Yewang; Zhang, Yihui; Xu, Hangxun; Hanlon, Roger T.; Huang, Yonggang; Rogers, John A.

    2014-01-01

    Octopus, squid, cuttlefish, and other cephalopods exhibit exceptional capabilities for visually adapting to or differentiating from the coloration and texture of their surroundings, for the purpose of concealment, communication, predation, and reproduction. Long-standing interest in and emerging understanding of the underlying ultrastructure, physiological control, and photonic interactions has recently led to efforts in the construction of artificial systems that have key attributes found in the skins of these organisms. Despite several promising options in active materials for mimicking biological color tuning, existing routes to integrated systems do not include critical capabilities in distributed sensing and actuation. Research described here represents progress in this direction, demonstrated through the construction, experimental study, and computational modeling of materials, device elements, and integration schemes for cephalopod-inspired flexible sheets that can autonomously sense and adapt to the coloration of their surroundings. These systems combine high-performance, multiplexed arrays of actuators and photodetectors in laminated, multilayer configurations on flexible substrates, with overlaid arrangements of pixelated, color-changing elements. The concepts provide realistic routes to thin sheets that can be conformally wrapped onto solid objects to modulate their visual appearance, with potential relevance to consumer, industrial, and military applications. PMID:25136094

  6. Global Squeeze: Assessing Climate-Critical Resource Constraints for Coastal Climate Adaptation

    NASA Astrophysics Data System (ADS)

    Chase, N. T.; Becker, A.; Schwegler, B.; Fischer, M.

    2014-12-01

    The projected impacts of climate change in the coastal zone will require local planning and local resources to adapt to increasing risks of social, environmental, and economic consequences from extreme events. This means that, for the first time in human history, aggregated local demands could outpace global supply of certain "climate-critical resources." For example, construction materials such as sand and gravel, steel, and cement may be needed to fortify many coastal locations at roughly the same point in time if decision makers begin to construct new storm barriers or elevate coastal lands. Where might adaptation bottlenecks occur? Can the world produce enough cement to armour the world's seaports as flood risks increase due to sea-level rise and more intense storms? Just how many coastal engineers would multiple such projects require? Understanding such global implications of adaptation requires global datasets—such as bathymetry, coastal topography, local sea-level rise and storm surge projections, and construction resource production capacity—that are currently unavailable at a resolution appropriate for a global-scale analysis. Our research group has identified numerous gaps in available data necessary to make such estimates on both the supply and demand sides of this equation. This presentation examines the emerging need and current availability of these types of datasets and argues for new coordinated efforts to develop and share such data.

  7. Complex ordering in spin networks: Critical role of adaptation rate for dynamically evolving interactions

    NASA Astrophysics Data System (ADS)

    Pathak, Anand; Sinha, Sitabhra

    2015-09-01

    Many complex systems can be represented as networks of dynamical elements whose states evolve in response to interactions with neighboring elements, noise and external stimuli. The collective behavior of such systems can exhibit remarkable ordering phenomena such as chimera order corresponding to coexistence of ordered and disordered regions. Often, the interactions in such systems can also evolve over time responding to changes in the dynamical states of the elements. Link adaptation inspired by Hebbian learning, the dominant paradigm for neuronal plasticity, has been earlier shown to result in structural balance by removing any initial frustration in a system that arises through conflicting interactions. Here we show that the rate of the adaptive dynamics for the interactions is crucial in deciding the emergence of different ordering behavior (including chimera) and frustration in networks of Ising spins. In particular, we observe that small changes in the link adaptation rate about a critical value result in the system exhibiting radically different energy landscapes, viz., smooth landscape corresponding to balanced systems seen for fast learning, and rugged landscapes corresponding to frustrated systems seen for slow learning.

  8. A Critical Period for Postnatal Adaptive Plasticity in a Model of Motor Axon Miswiring

    PubMed Central

    Castiblanco-Urbina, Maria A.; Winzeck, Stefan; Sundermeier, Julia; Theis, Fabian J.; Fouad, Karim; Huber, Andrea B.

    2015-01-01

    The correct wiring of neuronal circuits is of crucial importance for precise neuromuscular functionality. Therefore, guidance cues provide tight spatiotemporal control of axon growth and guidance. Mice lacking the guidance cue Semaphorin 3F (Sema3F) display very specific axon wiring deficits of motor neurons in the medial aspect of the lateral motor column (LMCm). While these deficits have been investigated extensively during embryonic development, it remained unclear how Sema3F mutant mice cope with these errors postnatally. We therefore investigated whether these animals provide a suitable model for the exploration of adaptive plasticity in a system of miswired neuronal circuitry. We show that the embryonically developed wiring deficits in Sema3F mutants persist until adulthood. As a consequence, these mutants display impairments in motor coordination that improve during normal postnatal development, but never reach wildtype levels. These improvements in motor coordination were boosted to wildtype levels by housing the animals in an enriched environment starting at birth. In contrast, a delayed start of enriched environment housing, at 4 weeks after birth, did not similarly affect motor performance of Sema3F mutants. These results, which are corroborated by neuroanatomical analyses, suggest a critical period for adaptive plasticity in neuromuscular circuitry. Interestingly, the formation of perineuronal nets, which are known to close the critical period for plastic changes in other systems, was not altered between the different housing groups. However, we found significant changes in the number of excitatory synapses on limb innervating motor neurons. Thus, we propose that during the early postnatal phase, when perineuronal nets have not yet been formed around spinal motor neurons, housing in enriched environment conditions induces adaptive plasticity in the motor system by the formation of additional synaptic contacts, in order to compensate for coordination

  9. Design as a Critical Tool in Bariatric Patient Care

    PubMed Central

    Wignall, Doug

    2008-01-01

    Both men and women in the United States are roughly an inch taller and 25 pounds heavier than they were in 1960, says the National Center for Health Statistics at the Centers for Disease Control and Prevention. An increasing number are also overweight or obese. In fact, obesity has become an alarming epidemic with enormous implications for our health care system. A critical concern is the ability to care physically and emotionally for this segment of the patient population. Respecting patient dignity and delivering optimum clinical care are primary issues, as are establishing procedures for safeguarding the health and well-being of these patients and their caregivers. Design is a critical tool in the care of and the improved long-term clinical outcomes for bariatric patients; success mandates a three-prong approach to the design process: appropriate facilities and space, proper equipment and furnishings, and training and standardized care protocols. Together, these components ensure the ability of a health care provider to adequately care for all patients—including this newest and rapidly growing patient segment—with equality and dignity. PMID:19885353

  10. Optical Design for Extremely Large Telescope Adaptive Optics Systems

    SciTech Connect

    Bauman, B J

    2003-11-26

    Designing an adaptive optics (AO) system for extremely large telescopes (ELT's) will present new optical engineering challenges. Several of these challenges are addressed in this work, including first-order design of multi-conjugate adaptive optics (MCAO) systems, pyramid wavefront sensors (PWFS's), and laser guide star (LGS) spot elongation. MCAO systems need to be designed in consideration of various constraints, including deformable mirror size and correction height. The y,{bar y} method of first-order optical design is a graphical technique that uses a plot with marginal and chief ray heights as coordinates; the optical system is represented as a segmented line. This method is shown to be a powerful tool in designing MCAO systems. From these analyses, important conclusions about configurations are derived. PWFS's, which offer an alternative to Shack-Hartmann (SH) wavefront sensors (WFS's), are envisioned as the workhorse of layer-oriented adaptive optics. Current approaches use a 4-faceted glass pyramid to create a WFS analogous to a quad-cell SH WFS. PWFS's and SH WFS's are compared and some newly-considered similarities and PWFS advantages are presented. Techniques to extend PWFS's are offered: First, PWFS's can be extended to more pixels in the image by tiling pyramids contiguously. Second, pyramids, which are difficult to manufacture, can be replaced by less expensive lenslet arrays. An approach is outlined to convert existing SH WFS's to PWFS's for easy evaluation of PWFS's. Also, a demonstration of PWFS's in sensing varying amounts of an aberration is presented. For ELT's, the finite altitude and finite thickness of LGS's means that the LGS will appear elongated from the viewpoint of subapertures not directly under the telescope. Two techniques for dealing with LGS spot elongation in SH WFS's are presented. One method assumes that the laser will be pulsed and uses a segmented micro-electromechanical system (MEMS) to track the LGS light subaperture by

  11. Optical design of the adaptive optics laser guide star system

    SciTech Connect

    Bissinger, H.

    1994-11-15

    The design of an adaptive optics package for the 3 meter Lick telescope is presented. This instrument package includes a 69 actuator deformable mirror and a Hartmann type wavefront sensor operating in the visible wavelength; a quadrant detector for the tip-tile sensor and a tip-tilt mirror to stabilize atmospheric first order tip-tile errors. A high speed computer drives the deformable mirror to achieve near diffraction limited imagery. The different optical components and their individual design constraints are described. motorized stages and diagnostics tools are used to operate and maintain alignment throughout observation time from a remote control room. The expected performance are summarized and actual results of astronomical sources are presented.

  12. ZAP! Adapted: Incorporating design in the introductory electromagnetism lab

    NASA Astrophysics Data System (ADS)

    McNeil, J. A.

    2002-04-01

    In the last decade the Accreditation Board of Engineering and Technology(ABET) significantly reformed the criteria by which engineering programs are accredited. The new criteria are called Engineering Criteria 2000 (EC2000). Not surprisingly, engineering design constitutes an essential component of these criteria. The Engineering Physics program at the Colorado School of Mines (CSM) underwent an ABET general review and site visit in the fall of 2000. In preparation for this review and as part of a campus-wide curriculum reform the Physics Department was challenged to include elements of design in its introductory laboratories. As part of the background research for this reform, several laboratory programs were reviewed including traditional and studio modes as well as a course used by Cal Tech and MIT called "ZAP!" which incorporates design activities well-aligned with the EC2000 criteria but in a nontraditional delivery mode. CSM has adapted several ZAP! experiments to a traditional laboratory format while attempting to preserve significant design experiences. The new laboratory forms an important component of the reformed course which attempts to respect the psychological principles of learner-based education. This talk reviews the reformed introductory electromagnetism course and how the laboratories are integrated into the pedagogy along with design activities. In their new form the laboratories can be readily adopted by physics departments using traditional delivery formats.

  13. Design of infrasound-detection system via adaptive LMSTDE algorithm

    NASA Technical Reports Server (NTRS)

    Khalaf, C. S.; Stoughton, J. W.

    1984-01-01

    A proposed solution to an aviation safety problem is based on passive detection of turbulent weather phenomena through their infrasonic emission. This thesis describes a system design that is adequate for detection and bearing evaluation of infrasounds. An array of four sensors, with the appropriate hardware, is used for the detection part. Bearing evaluation is based on estimates of time delays between sensor outputs. The generalized cross correlation (GCC), as the conventional time-delay estimation (TDE) method, is first reviewed. An adaptive TDE approach, using the least mean square (LMS) algorithm, is then discussed. A comparison between the two techniques is made and the advantages of the adaptive approach are listed. The behavior of the GCC, as a Roth processor, is examined for the anticipated signals. It is shown that the Roth processor has the desired effect of sharpening the peak of the correlation function. It is also shown that the LMSTDE technique is an equivalent implementation of the Roth processor in the time domain. A LMSTDE lead-lag model, with a variable stability coefficient and a convergence criterion, is designed.

  14. Adapt

    NASA Astrophysics Data System (ADS)

    Bargatze, L. F.

    2015-12-01

    Active Data Archive Product Tracking (ADAPT) is a collection of software routines that permits one to generate XML metadata files to describe and register data products in support of the NASA Heliophysics Virtual Observatory VxO effort. ADAPT is also a philosophy. The ADAPT concept is to use any and all available metadata associated with scientific data to produce XML metadata descriptions in a consistent, uniform, and organized fashion to provide blanket access to the full complement of data stored on a targeted data server. In this poster, we present an application of ADAPT to describe all of the data products that are stored by using the Common Data File (CDF) format served out by the CDAWEB and SPDF data servers hosted at the NASA Goddard Space Flight Center. These data servers are the primary repositories for NASA Heliophysics data. For this purpose, the ADAPT routines have been used to generate data resource descriptions by using an XML schema named Space Physics Archive, Search, and Extract (SPASE). SPASE is the designated standard for documenting Heliophysics data products, as adopted by the Heliophysics Data and Model Consortium. The set of SPASE XML resource descriptions produced by ADAPT includes high-level descriptions of numerical data products, display data products, or catalogs and also includes low-level "Granule" descriptions. A SPASE Granule is effectively a universal access metadata resource; a Granule associates an individual data file (e.g. a CDF file) with a "parent" high-level data resource description, assigns a resource identifier to the file, and lists the corresponding assess URL(s). The CDAWEB and SPDF file systems were queried to provide the input required by the ADAPT software to create an initial set of SPASE metadata resource descriptions. Then, the CDAWEB and SPDF data repositories were queried subsequently on a nightly basis and the CDF file lists were checked for any changes such as the occurrence of new, modified, or deleted

  15. A Year of Progress: NASA's Space Launch System Approaches Critical Design Review

    NASA Technical Reports Server (NTRS)

    Askins, Bruce; Robinson, Kimberly

    2015-01-01

    NASA's Space Launch System (SLS) made significant progress on the manufacturing floor and on the test stand in 2014 and positioned itself for a successful Critical Design Review in mid-2015. SLS, the world's only exploration-class heavy lift rocket, has the capability to dramatically increase the mass and volume of human and robotic exploration. Additionally, it will decrease overall mission risk, increase safety, and simplify ground and mission operations - all significant considerations for crewed missions and unique high-value national payloads. Development now is focused on configuration with 70 metric tons (t) of payload to low Earth orbit (LEO), more than double the payload of the retired Space Shuttle program or current operational vehicles. This "Block 1" design will launch NASA's Orion Multi-Purpose Crew Vehicle (MPCV) on an uncrewed flight beyond the Moon and back and the first crewed flight around the Moon. The current design has a direct evolutionary path to a vehicle with a 130t lift capability that offers even more flexibility to reduce planetary trip times, simplify payload design cycles, and provide new capabilities such as planetary sample returns. Every major element of SLS has successfully completed its Critical Design Review and now has hardware in production or testing. In fact, the SLS MPCV-to-Stage-Adapter (MSA) flew successfully on the Exploration Flight Test (EFT) 1 launch of a Delta IV and Orion spacecraft in December 2014. The SLS Program is currently working toward vehicle Critical Design Review in mid-2015. This paper will discuss these and other technical and programmatic successes and challenges over the past year and provide a preview of work ahead before the first flight of this new capability.

  16. Robust Engineering Designs for Infrastructure Adaptation to a Changing Climate

    NASA Astrophysics Data System (ADS)

    Samaras, C.; Cook, L.

    2015-12-01

    Infrastructure systems are expected to be functional, durable and safe over long service lives - 50 to over 100 years. Observations and models of climate science show that greenhouse gas emissions resulting from human activities have changed climate, weather and extreme events. Projections of future changes (albeit with uncertainties caused by inadequacies of current climate/weather models) can be made based on scenarios for future emissions, but actual future emissions are themselves uncertain. Most current engineering standards and practices for infrastructure assume that the probabilities of future extreme climate and weather events will match those of the past. Climate science shows that this assumption is invalid, but is unable, at present, to define these probabilities over the service lives of existing and new infrastructure systems. Engineering designs, plans, and institutions and regulations will need to be adaptable for a range of future conditions (conditions of climate, weather and extreme events, as well as changing societal demands for infrastructure services). For their current and future projects, engineers should: Involve all stakeholders (owners, financers, insurance, regulators, affected public, climate/weather scientists, etc.) in key decisions; Use low regret, adaptive strategies, such as robust decision making and the observational method, comply with relevant standards and regulations, and exceed their requirements where appropriate; Publish design studies and performance/failure investigations to extend the body of knowledge for advancement of practice. The engineering community should conduct observational and modeling research with climate/weather/social scientists and the concerned communities and account rationally for climate change in revised engineering standards and codes. This presentation presents initial research on decisionmaking under uncertainty for climate resilient infrastructure design.

  17. Critical design factors for sector transport maintenance in DEMO

    NASA Astrophysics Data System (ADS)

    Utoh, Hiroyasu; Someya, Youji; Tobita, Kenji; Asakura, Nobuyuki; Hoshino, Kazuo; Nakamura, Makoto

    2013-12-01

    This paper mainly focuses on a sector transport maintenance scheme from the aspects of high plant availability. In this study, three different maintenance schemes are considered based on (1) the number of maintenance ports and (2) the insertion direction. The design study clarifies critical design factors and key engineering issues on the maintenance scheme: (1) how to support an enormous overturning force of the toroidal field coils in the large open port for sector transport and (2) define the transferring mechanism of sectors in the vacuum vessel. On reviewing these assessment factors, the sector transport using a limited number of horizontal maintenance ports is found to be a more realistic maintenance scheme. In addition, evaluating maintenance scenarios under high decay heat is proposed for the first time. The key design factors are the cool-down time in the reactor and the cooling method in the maintenance scheme to keep components under operational temperature. Based on one-dimensional heat conduction analysis, after one month cool-down time, each sector of SlimCS could be transported to the hot cell facility by gas cooling.

  18. Microsystem design framework based on tool adaptations and library developments

    NASA Astrophysics Data System (ADS)

    Karam, Jean Michel; Courtois, Bernard; Rencz, Marta; Poppe, Andras; Szekely, Vladimir

    1996-09-01

    Besides foundry facilities, Computer-Aided Design (CAD) tools are also required to move microsystems from research prototypes to an industrial market. This paper describes a Computer-Aided-Design Framework for microsystems, based on selected existing software packages adapted and extended for microsystem technology, assembled with libraries where models are available in the form of standard cells described at different levels (symbolic, system/behavioral, layout). In microelectronics, CAD has already attained a highly sophisticated and professional level, where complete fabrication sequences are simulated and the device and system operation is completely tested before manufacturing. In comparison, the art of microsystem design and modelling is still in its infancy. However, at least for the numerical simulation of the operation of single microsystem components, such as mechanical resonators, thermo-elements, elastic diaphragms, reliable simulation tools are available. For the different engineering disciplines (like electronics, mechanics, optics, etc) a lot of CAD-tools for the design, simulation and verification of specific devices are available, but there is no CAD-environment within which we could perform a (micro-)system simulation due to the different nature of the devices. In general there are two different approaches to overcome this limitation: the first possibility would be to develop a new framework tailored for microsystem-engineering. The second approach, much more realistic, would be to use the existing CAD-tools which contain the most promising features, and to extend these tools so that they can be used for the simulation and verification of microsystems and of the devices involved. These tools are assembled with libraries in a microsystem design environment allowing a continuous design flow. The approach is driven by the wish to make microsystems accessible to a large community of people, including SMEs and non-specialized academic institutions.

  19. Adaptive automation, trust, and self-confidence in fault management of time-critical tasks.

    PubMed

    Moray, N; Inagaki, T; Itoh, M

    2000-03-01

    An experiment on adaptive automation is described. Reliability of automated fault diagnosis, mode of fault management (manual vs. automated), and fault dynamics affect variables including root mean square error, avoidance of accidents and false shutdowns, subjective trust in the system, and operator self-confidence. Results are discussed in relation to levels of automation, models of trust and self-confidence, and theories of human-machine function allocation. Trust in automation but not self-confidence was strongly affected by automation reliability. Operators controlled a continuous process with difficulty only while performing fault management but could prevent unnecessary shutdowns. Final authority for decisions and action must be allocated to automation in time-critical situations.

  20. From consent to institutions: designing adaptive governance for genomic biobanks.

    PubMed

    O'Doherty, Kieran C; Burgess, Michael M; Edwards, Kelly; Gallagher, Richard P; Hawkins, Alice K; Kaye, Jane; McCaffrey, Veronica; Winickoff, David E

    2011-08-01

    Biobanks are increasingly hailed as powerful tools to advance health research. The social and ethical challenges associated with the implementation and operation of biobanks are equally well-documented. One of the proposed solutions to these challenges involves trading off a reduction in the specificity of informed consent protocols with an increased emphasis on governance. However, little work has gone into formulating what such governance might look like. In this paper, we suggest four general principles that should inform biobank governance and illustrate the enactment of these principles in a proposed governance model for a particular population-scale biobank, the British Columbia (BC) Generations Project. We begin by outlining four principles that we see as necessary for informing sustainable and effective governance of biobanks: (1) recognition of research participants and publics as a collective body, (2) trustworthiness, (3) adaptive management, and (4) fit between the nature of a particular biobank and the specific structural elements of governance adopted. Using the BC Generations Project as a case study, we then offer as a working model for further discussion the outlines of a proposed governance structure enacting these principles. Ultimately, our goal is to design an adaptive governance approach that can protect participant interests as well as promote effective translational health sciences. PMID:21726926

  1. Wireless thermal sensor network with adaptive low power design.

    PubMed

    Lee, Ho-Yin; Chen, Shih-Lun; Chen, Chiung-An; Huang, Hong-Yi; Luo, Ching-Hsing

    2007-01-01

    There is an increasing need to develop flexible, reconfigurable, and intelligent low power wireless sensor network (WSN) system for healthcare applications. Technical advancements in micro-sensors, MEMS devices, low power electronics, and radio frequency circuits have enabled the design and development of such highly integrated system. In this paper, we present our proposed wireless thermal sensor network system, which is separated into control and data paths. Both of these paths have their own transmission frequencies. The control path sends the power and function commands from computer to each sensor elements by 2.4GHz RF circuits and the data path transmits measured data by 2.4GHz in sensor layer and 60GHz in higher layers. This hierarchy architecture would make reconfigurable mapping and pipeline applications on WSN possibly, and the average power consumption can be efficiently reduced about 60% by using the adaptive technique. PMID:18003354

  2. Decentralized adaptive control designs and microstrip antennas for smart structures

    NASA Astrophysics Data System (ADS)

    Khorrami, Farshad; Jain, Sandeep; Das, Nirod K.

    1996-05-01

    Smart structures lend themselves naturally to a decentralized control design framework, especially with adaptation mechanisms. The main reason being that it is highly undesirable to connect all the sensors and actuators in a large structure to a central processor. It is rather desirable to have local decision-making at each smart patch. Furthermore, this local controllers should be easily `expandable' to `contractible.' This corresponds to the fact that addition/deletion of several smart patches should not require a total redesign of the control system. The decentralized control strategies advocated in this paper are of expandable/contractible type. On another front, we are considering utilization of micro-strip antennas for power transfer to and from smart structures. We have made preliminary contributions in this direction and further developments are underway. These approaches are being pursued for active vibration damping and noise cancellation via piezoelectric ceramics although the methodology is general enough to be applicable to other type of active structures.

  3. Design, realization and structural testing of a compliant adaptable wing

    NASA Astrophysics Data System (ADS)

    Molinari, G.; Quack, M.; Arrieta, A. F.; Morari, M.; Ermanni, P.

    2015-10-01

    This paper presents the design, optimization, realization and testing of a novel wing morphing concept, based on distributed compliance structures, and actuated by piezoelectric elements. The adaptive wing features ribs with a selectively compliant inner structure, numerically optimized to achieve aerodynamically efficient shape changes while simultaneously withstanding aeroelastic loads. The static and dynamic aeroelastic behavior of the wing, and the effect of activating the actuators, is assessed by means of coupled 3D aerodynamic and structural simulations. To demonstrate the capabilities of the proposed morphing concept and optimization procedure, the wings of a model airplane are designed and manufactured according to the presented approach. The goal is to replace conventional ailerons, thus to achieve controllability in roll purely by morphing. The mechanical properties of the manufactured components are characterized experimentally, and used to create a refined and correlated finite element model. The overall stiffness, strength, and actuation capabilities are experimentally tested and successfully compared with the numerical prediction. To counteract the nonlinear hysteretic behavior of the piezoelectric actuators, a closed-loop controller is implemented, and its capability of accurately achieving the desired shape adaptation is evaluated experimentally. Using the correlated finite element model, the aeroelastic behavior of the manufactured wing is simulated, showing that the morphing concept can provide sufficient roll authority to allow controllability of the flight. The additional degrees of freedom offered by morphing can be also used to vary the plane lift coefficient, similarly to conventional flaps. The efficiency improvements offered by this technique are evaluated numerically, and compared to the performance of a rigid wing.

  4. The Effect of Three Computer Conferencing Designs on Critical Thinking Skills of Nursing Students

    ERIC Educational Resources Information Center

    Duphorne, Patsy L.; Gunawardena, Charlotte N.

    2005-01-01

    A study of university nursing students tested the effect of computer conference designs and advance organizers on critical thinking skills. Critical thinking, although not significantly different between three conference groups, was evident for groups in all three conference designs. Those conferences designed to facilitate critical inquiry showed…

  5. 78 FR 8745 - Endangered and Threatened Wildlife and Plants; Designation of Critical Habitat for Tidewater Goby

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-06

    ... 2008 critical habitat designation was published in the Federal Register on October 19, 2011 (76 FR... following changes to the critical habitat designation. The 2008 final critical habitat designation (73 FR...) in the Federal Register on July 24, 2012 (77 FR 43222), allowing the public to provide comments...

  6. Impacting patient outcomes through design: acuity adaptable care/universal room design.

    PubMed

    Brown, Katherine Kay; Gallant, Dennis

    2006-01-01

    To succeed in today's challenging healthcare environment, hospitals must examine their impact on customers--patients and families--staff and physicians. By using competitive facility design and incorporating evidence-based concepts such as the acuity adaptable care delivery model and the universal room, the hospital will realize an impact on patient satisfaction that will enhance market share, on physician satisfaction that will foster loyalty, and on staff satisfaction that will decrease turnover. At the same time, clinical outcomes such as a reduction in mortality and complications and efficiencies such as a reduction in length of stay and minimization of hospital costs through the elimination of transfers can be gained. The results achieved are dependent on the principles used in designing the patient room that should focus on maximizing patient safety and improving healing. This article will review key design elements that support the success of an acuity adaptable unit such as the use of a private room with zones dedicated to patients, families, and staff, healing environment, technology, and decentralized nursing stations that support the success of the acuity adaptable unit. Outcomes of institutions currently utilizing the acuity adaptable concept will be reviewed.

  7. Flight critical system design guidelines and validation methods

    NASA Technical Reports Server (NTRS)

    Holt, H. M.; Lupton, A. O.; Holden, D. G.

    1984-01-01

    Efforts being expended at NASA-Langley to define a validation methodology, techniques for comparing advanced systems concepts, and design guidelines for characterizing fault tolerant digital avionics are described with an emphasis on the capabilities of AIRLAB, an environmentally controlled laboratory. AIRLAB has VAX 11/750 and 11/780 computers with an aggregate of 22 Mb memory and over 650 Mb storage, interconnected at 256 kbaud. An additional computer is programmed to emulate digital devices. Ongoing work is easily accessed at user stations by either chronological or key word indexing. The CARE III program aids in analyzing the capabilities of test systems to recover from faults. An additional code, the semi-Markov unreliability program (SURE) generates upper and lower reliability bounds. The AIRLAB facility is mainly dedicated to research on designs of digital flight-critical systems which must have acceptable reliability before incorporation into aircraft control systems. The digital systems would be too costly to submit to a full battery of flight tests and must be initially examined with the AIRLAB simulation capabilities.

  8. Design and Criticality Considerations for 9977 and 9978 Shipping Packages

    SciTech Connect

    Reed, R; Biswas, D; Abramczyk, G

    2008-11-25

    Savannah River National Laboratory (SRNL) has developed two new, Type B, state-of-the-art, general purpose, fissile material Shipping Packages, designated 9977 and 9978, as replacements for the U.S. DOT specification 6M container, phased out in September 30, 2008 due to non-compliance with current requirements 10CFR71 regulation. The packages accommodate plutonium, uranium and other special nuclear materials in bulk quantities and in many forms with capabilities exceeding those of the 6M. These packages provide a high degree of single containment and comply with 10CFR71, Department of Energy (DOE) Order 460.1B, DOE Order 460.2, and 10CFR20 (As Low As Reasonably Achievable (ALARA)). Allowed package contents were determined accounting for nuclear criticality, radiation shielding, and decay heat rate. The Criticality Safety Index (CSI) for the package is 1.0. The package utilizes passive cooling to maintain internal temperatures within limits. Radiation shielding analyses have established the contents for which the packages can be shipped under non-exclusive use in the Safe-Secure Trailer or under exclusive use. The packages are designed to ship radioactive contents in several configurations; Radioisotope Thermoelectric Generators (RTGs), nested food-pack cans, site specific containers, and DOE-STD-3013 containers. Each shipping package includes a 35-gallon stainless steel outer drum, insulation, a drum liner, and a single containment vessel (CV). The 9977 includes a 6-inch ID CV while the 9978 includes a 5-inch ID CV. One inch of Fiberfrax{reg_sign} insulation is wrapped around and attached to the sides and bottom of the liner. The volume between the Fiberfrax{reg_sign} and the drum wall is filled with polyurethane foam. Top and bottom aluminum Load Distribution Fixtures (LDFs) within the drum liner cavity, above and below the CV, center the CV in the liner, stiffen the package radially, and distribute loads away from the CV. The 6CV fits directly into the LDFs while

  9. Genomic Measures to Predict Adaptation to Novel Sensorimotor Environments and Improve Personalization of Countermeasure Design

    NASA Technical Reports Server (NTRS)

    Kreutzberg, G. A.; Zanello, S.; Seidler, R. D.; Peters, B.; De Dios, Y. E.; Gadd, N. E.; Bloomberg, J. J.; Mulavara, A. P.

    2016-01-01

    Introduction. Astronauts experience sensorimotor disturbances during their initial exposure to microgravity and during the re-adaptation phase following a return to an Earth-gravitational environment. These alterations may affect crewmembers' ability to perform mission-critical functional tasks. Interestingly, astronauts have shown significant inter-subject variation in adaptive capability during gravitational transitions. The ability to predict the manner and degree to which individual astronauts would be affected would improve the efficacy of personalized countermeasure training programs designed to enhance sensorimotor adaptability. The success of such an approach depends on the development of predictive measures of sensorimotor adaptation, which would ascertain each crewmember's adaptive capacity. The goal of this study is to determine whether specific genetic polymorphisms have significant influence on sensorimotor adaptability, which can help inform the design of personalized training countermeasures. Methods. Subjects (n=15) were tested on their ability to negotiate a complex obstacle course for ten test trials while wearing up-down vision-displacing goggles. This presented a visuomotor challenge while doing a full body task. The first test trial time and the recovery rate over the ten trials were used as adaptability performance metrics. Four single nucleotide polymorphisms (SNPs) were selected for their role in neural pathways underlying sensorimotor adaptation and were identified in subjects' DNA extracted from saliva samples: catechol-O-methyl transferase (COMT, rs4680), dopamine receptor D2 (DRD2, rs1076560), brain-derived neurotrophic factor genes (BDNF, rs6265), and the DraI polymorphism of the alpha-2 adrenergic receptor. The relationship between the SNPs and test performance was assessed by assigning subjects a rank score based on their adaptability performance metrics and comparing gene expression between the top half and bottom half performers

  10. A Cost Effective System Design Approach for Critical Space Systems

    NASA Technical Reports Server (NTRS)

    Abbott, Larry Wayne; Cox, Gary; Nguyen, Hai

    2000-01-01

    NASA-JSC required an avionics platform capable of serving a wide range of applications in a cost-effective manner. In part, making the avionics platform cost effective means adhering to open standards and supporting the integration of COTS products with custom products. Inherently, operation in space requires low power, mass, and volume while retaining high performance, reconfigurability, scalability, and upgradability. The Universal Mini-Controller project is based on a modified PC/104-Plus architecture while maintaining full compatibility with standard COTS PC/104 products. The architecture consists of a library of building block modules, which can be mixed and matched to meet a specific application. A set of NASA developed core building blocks, processor card, analog input/output card, and a Mil-Std-1553 card, have been constructed to meet critical functions and unique interfaces. The design for the processor card is based on the PowerPC architecture. This architecture provides an excellent balance between power consumption and performance, and has an upgrade path to the forthcoming radiation hardened PowerPC processor. The processor card, which makes extensive use of surface mount technology, has a 166 MHz PowerPC 603e processor, 32 Mbytes of error detected and corrected RAM, 8 Mbytes of Flash, and I Mbytes of EPROM, on a single PC/104-Plus card. Similar densities have been achieved with the quad channel Mil-Std-1553 card and the analog input/output cards. The power management built into the processor and its peripheral chip allows the power and performance of the system to be adjusted to meet the requirements of the application, allowing another dimension to the flexibility of the Universal Mini-Controller. Unique mechanical packaging allows the Universal Mini-Controller to accommodate standard COTS and custom oversized PC/104-Plus cards. This mechanical packaging also provides thermal management via conductive cooling of COTS boards, which are typically

  11. Critical Zone Experimental Design to Assess Soil Processes and Function

    NASA Astrophysics Data System (ADS)

    Banwart, Steve

    2010-05-01

    experimental design studies soil processes across the temporal evolution of the soil profile, from its formation on bare bedrock, through managed use as productive land to its degradation under longstanding pressures from intensive land use. To understand this conceptual life cycle of soil, we have selected 4 European field sites as Critical Zone Observatories. These are to provide data sets of soil parameters, processes and functions which will be incorporated into the mathematical models. The field sites are 1) the BigLink field station which is located in the chronosequence of the Damma Glacier forefield in alpine Switzerland and is established to study the initial stages of soil development on bedrock; 2) the Lysina Catchment in the Czech Republic which is representative of productive soils managed for intensive forestry, 3) the Fuchsenbigl Field Station in Austria which is an agricultural research site that is representative of productive soils managed as arable land and 4) the Koiliaris Catchment in Crete, Greece which represents degraded Mediterranean region soils, heavily impacted by centuries of intensive grazing and farming, under severe risk of desertification.

  12. Designing a suite of measurements to understand the critical zone

    NASA Astrophysics Data System (ADS)

    Brantley, Susan L.; DiBiase, Roman A.; Russo, Tess A.; Shi, Yuning; Lin, Henry; Davis, Kenneth J.; Kaye, Margot; Hill, Lillian; Kaye, Jason; Eissenstat, David M.; Hoagland, Beth; Dere, Ashlee L.; Neal, Andrew L.; Brubaker, Kristen M.; Arthur, Dan K.

    2016-03-01

    Many scientists have begun to refer to the earth surface environment from the upper canopy to the depths of bedrock as the critical zone (CZ). Identification of the CZ as an integral object worthy of study implicitly posits that the study of the whole earth surface will provide benefits that do not arise when studying the individual parts. To study the CZ, however, requires prioritizing among the measurements that can be made - and we do not generally agree on the priorities. Currently, the Susquehanna Shale Hills Critical Zone Observatory (SSHCZO) is expanding from a small original focus area (0.08 km2, Shale Hills catchment), to a larger watershed (164 km2, Shavers Creek watershed) and is grappling with the prioritization. This effort is an expansion from a monolithologic first-order forested catchment to a watershed that encompasses several lithologies (shale, sandstone, limestone) and land use types (forest, agriculture). The goal of the project remains the same: to understand water, energy, gas, solute, and sediment (WEGSS) fluxes that are occurring today in the context of the record of those fluxes over geologic time as recorded in soil profiles, the sedimentary record, and landscape morphology. Given the small size of the Shale Hills catchment, the original design incorporated measurement of as many parameters as possible at high temporal and spatial density. In the larger Shavers Creek watershed, however, we must focus the measurements. We describe a strategy of data collection and modeling based on a geomorphological and land use framework that builds on the hillslope as the basic unit. Interpolation and extrapolation beyond specific sites relies on geophysical surveying, remote sensing, geomorphic analysis, the study of natural integrators such as streams, groundwaters or air, and application of a suite of CZ models. We hypothesize that measurements of a few important variables at strategic locations within a geomorphological framework will allow

  13. Designing a suite of measurements to understand the critical zone

    NASA Astrophysics Data System (ADS)

    Brantley, S. L.; DiBiase, R.; Russo, T.; Shi, Y.; Lin, H.; Davis, K. J.; Kaye, M.; Hill, L.; Kaye, J.; Neal, A. L.; Eissenstat, D.; Hoagland, B.; Dere, A. L.

    2015-09-01

    Many scientists have begun to refer to the earth surface environment from the upper canopy to the depths of bedrock as the critical zone (CZ). Identification of the CZ as a worthy object of study implicitly posits that the study of the whole earth surface will provide benefits that do not arise when studying the individual parts. To study the CZ, however, requires prioritizing among the measurements that can be made - and we do not generally agree on the priorities. Currently, the Susquehanna Shale Hills Critical Zone Observatory (SSHCZO) is expanding from a small original study area (0.08 km2, Shale Hills catchment), to a much larger watershed (164 km2, Shavers Creek watershed) and is grappling with the necessity of prioritization. This effort is an expansion from a monolithologic first-order forested catchment to a watershed that encompasses several lithologies (shale, sandstone, limestone) and land use types (forest, agriculture). The goal of the project remains the same: to understand water, energy, gas, solute and sediment (WEGSS) fluxes that are occurring today in the context of the record of those fluxes over geologic time as recorded in soil profiles, the sedimentary record, and landscape morphology. Given the small size of the original Shale Hills catchment, the original measurement design resulted in measurement of as many parameters as possible at high temporal and spatial density. In the larger Shavers Creek watershed, however, we must focus the measurements. We describe a strategy of data collection and modelling based on a geomorphological framework that builds on the hillslope as the basic unit. Interpolation and extrapolation beyond specific sites relies on geophysical surveying, remote sensing, geomorphic analysis, the study of natural integrators such as streams, ground waters or air, and application of a suite of CZ models. In essence, we are hypothesizing that pinpointed measurements of a few important variables at strategic locations will allow

  14. Solution-verified reliability analysis and design of bistable MEMS using error estimation and adaptivity.

    SciTech Connect

    Eldred, Michael Scott; Subia, Samuel Ramirez; Neckels, David; Hopkins, Matthew Morgan; Notz, Patrick K.; Adams, Brian M.; Carnes, Brian; Wittwer, Jonathan W.; Bichon, Barron J.; Copps, Kevin D.

    2006-10-01

    This report documents the results for an FY06 ASC Algorithms Level 2 milestone combining error estimation and adaptivity, uncertainty quantification, and probabilistic design capabilities applied to the analysis and design of bistable MEMS. Through the use of error estimation and adaptive mesh refinement, solution verification can be performed in an automated and parameter-adaptive manner. The resulting uncertainty analysis and probabilistic design studies are shown to be more accurate, efficient, reliable, and convenient.

  15. 78 FR 51705 - Proposed Designation of Marine Critical Habitat for the Loggerhead Sea Turtle, Caretta caretta...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-21

    ... Marine Critical Habitat for the Loggerhead Sea Turtle, Caretta caretta, Under the Endangered Species Act... related to our Proposed Designation of Marine Critical Habitat for the Loggerhead Sea Turtle, Caretta... Designation of Critical Habitat for the Northwest Atlantic Ocean Loggerhead Sea Turtle Distinct...

  16. 78 FR 38895 - Endangered and Threatened Wildlife and Plants; Threatened Status and Designation of Critical...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-28

    ... Bluffs bladderpod) as threatened and to designate critical habitat for these species (77 FR 28704). We... final critical habitat rule under Docket No. FWS-R1-ES-2013-0012 (78 FR 24008). The provisions of the... listing and designation of critical habitat (78 FR 30839) and published a document to delay the...

  17. Optical Design and Optimization of Translational Reflective Adaptive Optics Ophthalmoscopes

    NASA Astrophysics Data System (ADS)

    Sulai, Yusufu N. B.

    The retina serves as the primary detector for the biological camera that is the eye. It is composed of numerous classes of neurons and support cells that work together to capture and process an image formed by the eye's optics, which is then transmitted to the brain. Loss of sight due to retinal or neuro-ophthalmic disease can prove devastating to one's quality of life, and the ability to examine the retina in vivo is invaluable in the early detection and monitoring of such diseases. Adaptive optics (AO) ophthalmoscopy is a promising diagnostic tool in early stages of development, still facing significant challenges before it can become a clinical tool. The work in this thesis is a collection of projects with the overarching goal of broadening the scope and applicability of this technology. We begin by providing an optical design approach for AO ophthalmoscopes that reduces the aberrations that degrade the performance of the AO correction. Next, we demonstrate how to further improve image resolution through the use of amplitude pupil apodization and non-common path aberration correction. This is followed by the development of a viewfinder which provides a larger field of view for retinal navigation. Finally, we conclude with the development of an innovative non-confocal light detection scheme which improves the non-invasive visualization of retinal vasculature and reveals the cone photoreceptor inner segments in healthy and diseased eyes.

  18. Accelerated search for materials with targeted properties by adaptive design

    PubMed Central

    Xue, Dezhen; Balachandran, Prasanna V.; Hogden, John; Theiler, James; Xue, Deqing; Lookman, Turab

    2016-01-01

    Finding new materials with targeted properties has traditionally been guided by intuition, and trial and error. With increasing chemical complexity, the combinatorial possibilities are too large for an Edisonian approach to be practical. Here we show how an adaptive design strategy, tightly coupled with experiments, can accelerate the discovery process by sequentially identifying the next experiments or calculations, to effectively navigate the complex search space. Our strategy uses inference and global optimization to balance the trade-off between exploitation and exploration of the search space. We demonstrate this by finding very low thermal hysteresis (ΔT) NiTi-based shape memory alloys, with Ti50.0Ni46.7Cu0.8Fe2.3Pd0.2 possessing the smallest ΔT (1.84 K). We synthesize and characterize 36 predicted compositions (9 feedback loops) from a potential space of ∼800,000 compositions. Of these, 14 had smaller ΔT than any of the 22 in the original data set. PMID:27079901

  19. Accelerated search for materials with targeted properties by adaptive design

    NASA Astrophysics Data System (ADS)

    Xue, Dezhen; Balachandran, Prasanna V.; Hogden, John; Theiler, James; Xue, Deqing; Lookman, Turab

    2016-04-01

    Finding new materials with targeted properties has traditionally been guided by intuition, and trial and error. With increasing chemical complexity, the combinatorial possibilities are too large for an Edisonian approach to be practical. Here we show how an adaptive design strategy, tightly coupled with experiments, can accelerate the discovery process by sequentially identifying the next experiments or calculations, to effectively navigate the complex search space. Our strategy uses inference and global optimization to balance the trade-off between exploitation and exploration of the search space. We demonstrate this by finding very low thermal hysteresis (ΔT) NiTi-based shape memory alloys, with Ti50.0Ni46.7Cu0.8Fe2.3Pd0.2 possessing the smallest ΔT (1.84 K). We synthesize and characterize 36 predicted compositions (9 feedback loops) from a potential space of ~800,000 compositions. Of these, 14 had smaller ΔT than any of the 22 in the original data set.

  20. Accelerated search for materials with targeted properties by adaptive design.

    PubMed

    Xue, Dezhen; Balachandran, Prasanna V; Hogden, John; Theiler, James; Xue, Deqing; Lookman, Turab

    2016-01-01

    Finding new materials with targeted properties has traditionally been guided by intuition, and trial and error. With increasing chemical complexity, the combinatorial possibilities are too large for an Edisonian approach to be practical. Here we show how an adaptive design strategy, tightly coupled with experiments, can accelerate the discovery process by sequentially identifying the next experiments or calculations, to effectively navigate the complex search space. Our strategy uses inference and global optimization to balance the trade-off between exploitation and exploration of the search space. We demonstrate this by finding very low thermal hysteresis (ΔT) NiTi-based shape memory alloys, with Ti50.0Ni46.7Cu0.8Fe2.3Pd0.2 possessing the smallest ΔT (1.84 K). We synthesize and characterize 36 predicted compositions (9 feedback loops) from a potential space of ∼800,000 compositions. Of these, 14 had smaller ΔT than any of the 22 in the original data set. PMID:27079901

  1. Evidence for adaptive design in human gaze preference.

    PubMed

    Conway, C A; Jones, B C; DeBruine, L M; Little, A C

    2008-01-01

    Many studies have investigated the physical cues that influence face preferences. By contrast, relatively few studies have investigated the effects of facial cues to the direction and valence of others' social interest (i.e. gaze direction and facial expressions) on face preferences. Here we found that participants demonstrated stronger preferences for direct gaze when judging the attractiveness of happy faces than that of disgusted faces, and that this effect of expression on the strength of attraction to direct gaze was particularly pronounced for judgements of opposite-sex faces (study 1). By contrast, no such opposite-sex bias in preferences for direct gaze was observed when participants judged the same faces for likeability (study 2). Collectively, these findings for a context-sensitive opposite-sex bias in preferences for perceiver-directed smiles, but not perceiver-directed disgust, suggest gaze preference functions, at least in part, to facilitate efficient allocation of mating effort, and evince adaptive design in the perceptual mechanisms that underpin face preferences. PMID:17986435

  2. Accelerated search for materials with targeted properties by adaptive design.

    PubMed

    Xue, Dezhen; Balachandran, Prasanna V; Hogden, John; Theiler, James; Xue, Deqing; Lookman, Turab

    2016-04-15

    Finding new materials with targeted properties has traditionally been guided by intuition, and trial and error. With increasing chemical complexity, the combinatorial possibilities are too large for an Edisonian approach to be practical. Here we show how an adaptive design strategy, tightly coupled with experiments, can accelerate the discovery process by sequentially identifying the next experiments or calculations, to effectively navigate the complex search space. Our strategy uses inference and global optimization to balance the trade-off between exploitation and exploration of the search space. We demonstrate this by finding very low thermal hysteresis (ΔT) NiTi-based shape memory alloys, with Ti50.0Ni46.7Cu0.8Fe2.3Pd0.2 possessing the smallest ΔT (1.84 K). We synthesize and characterize 36 predicted compositions (9 feedback loops) from a potential space of ∼800,000 compositions. Of these, 14 had smaller ΔT than any of the 22 in the original data set.

  3. Online training course on critical appraisal for nurses: adaptation and assessment

    PubMed Central

    2014-01-01

    Background Research is an essential activity for improving quality and efficiency in healthcare. The objective of this study was to train nurses from the public Basque Health Service (Osakidetza) in critical appraisal, promoting continuous training and the use of research in clinical practice. Methods This was a prospective pre-post test study. The InfoCritique course on critical appraisal was translated and adapted. A sample of 50 nurses and 3 tutors was recruited. Educational strategies and assessment instruments were established for the course. A course website was created that contained contact details of the teaching team and coordinator, as well as a course handbook and videos introducing the course. Assessment comprised the administration of questionnaires before and after the course, in order to explore the main intervention outcomes: knowledge acquired and self-learning readiness. Satisfaction was also measured at the end of the course. Results Of the 50 health professionals recruited, 3 did not complete the course for personal or work-related reasons. The mean score on the pre-course knowledge questionnaire was 70.5 out of 100, with a standard deviation of 11.96. In general, participants’ performance on the knowledge questionnaire improved after the course, as reflected in the notable increase of the mean score, to 86.6, with a standard deviation of 10.00. Further, analyses confirmed statistically significant differences between pre- and post-course results (p < 0.001). With regard to self-learning readiness, after the course, participants reported a greater readiness and ability for self-directed learning. Lastly, in terms of level of satisfaction with the course, the mean score was 7 out of 10. Conclusions Participants significantly improved their knowledge score and self-directed learning readiness after the educational intervention, and they were overall satisfied with the course. For the health system and nursing professionals, this type of

  4. Safe, Advanced, Adaptable Isolation System Eliminates the Need for Critical Lifts

    NASA Technical Reports Server (NTRS)

    Ginn, Starr

    2011-01-01

    The Starr Soft Support isolation system incorporates an automatically reconfigurable aircraft jack into NASA's existing 1-Hertz isolators. This enables an aircraft to float in mid-air without the need for a critical lift during ground vibration testing (GVT), significantly reducing testing risk, time, and costs. Currently incorporating the most advanced technology available, the 60,000-poundcapacity (27-metric-ton) isolation system is used for weight and measurement tests, control-surface free-play tests, and structural mode interaction tests without the need for any major reconfiguration, often saving days of time and significantly reducing labor costs. The Starr Soft Support isolation system consists of an aircraft-jacking device with three jacking points, each of which has an individual motor and accommodates up to 20,000 pounds (9 metric tons) for a total 60,000-pound (27-metric-ton) capacity. The system can be transported to the aircraft by forklift and placed at its jacking points using a pallet jack. The motors power the electric actuators, raising the aircraft above the ground until the landing gear can retract. Inflatable isolators then deploy, enabling the aircraft to float in mid-air, simulating a 1-Hertz free-free boundary condition. Inflatable isolators have been in use at NASA for years, enabling aircraft to literally float unsupported for highly accurate GVT. These isolators must be placed underneath the aircraft for this to occur. Traditionally, this is achieved by a critical lift a high-risk procedure in which a crane and flexible cord system are used to lift the aircraft. In contrast, the Starr Soft Support isolation system eliminates the need for critical lift by integrating the inflatable isolators into an aircraft jacking system. The system maintains vertical and horizontal isolating capabilities. The aircraft can be rolled onto the system, jacked up, and then the isolators can be inflated and positioned without any personnel needing to work

  5. Finite-horizon control-constrained nonlinear optimal control using single network adaptive critics.

    PubMed

    Heydari, Ali; Balakrishnan, Sivasubramanya N

    2013-01-01

    To synthesize fixed-final-time control-constrained optimal controllers for discrete-time nonlinear control-affine systems, a single neural network (NN)-based controller called the Finite-horizon Single Network Adaptive Critic is developed in this paper. Inputs to the NN are the current system states and the time-to-go, and the network outputs are the costates that are used to compute optimal feedback control. Control constraints are handled through a nonquadratic cost function. Convergence proofs of: 1) the reinforcement learning-based training method to the optimal solution; 2) the training error; and 3) the network weights are provided. The resulting controller is shown to solve the associated time-varying Hamilton-Jacobi-Bellman equation and provide the fixed-final-time optimal solution. Performance of the new synthesis technique is demonstrated through different examples including an attitude control problem wherein a rigid spacecraft performs a finite-time attitude maneuver subject to control bounds. The new formulation has great potential for implementation since it consists of only one NN with single set of weights and it provides comprehensive feedback solutions online, though it is trained offline.

  6. Finite-horizon control-constrained nonlinear optimal control using single network adaptive critics.

    PubMed

    Heydari, Ali; Balakrishnan, Sivasubramanya N

    2013-01-01

    To synthesize fixed-final-time control-constrained optimal controllers for discrete-time nonlinear control-affine systems, a single neural network (NN)-based controller called the Finite-horizon Single Network Adaptive Critic is developed in this paper. Inputs to the NN are the current system states and the time-to-go, and the network outputs are the costates that are used to compute optimal feedback control. Control constraints are handled through a nonquadratic cost function. Convergence proofs of: 1) the reinforcement learning-based training method to the optimal solution; 2) the training error; and 3) the network weights are provided. The resulting controller is shown to solve the associated time-varying Hamilton-Jacobi-Bellman equation and provide the fixed-final-time optimal solution. Performance of the new synthesis technique is demonstrated through different examples including an attitude control problem wherein a rigid spacecraft performs a finite-time attitude maneuver subject to control bounds. The new formulation has great potential for implementation since it consists of only one NN with single set of weights and it provides comprehensive feedback solutions online, though it is trained offline. PMID:24808214

  7. Current Practice in Designing Training for Complex Skills: Implications for Design and Evaluation of ADAPT[IT].

    ERIC Educational Resources Information Center

    Eseryel, Deniz; Schuver-van Blanken, Marian J.; Spector, J. Michael

    ADAPT[IT] (Advanced Design Approach for Personalized Training-Interactive Tools is a European project coordinated by the Dutch National Aerospace Laboratory. The aim of ADAPT[IT] is to create and validate an effective training design methodology, based on cognitive science and leading to the integration of advanced technologies, so that the…

  8. Coaching Literacy Teachers as They Design Critical Literacy Practices

    ERIC Educational Resources Information Center

    Rogers, Rebecca

    2014-01-01

    Literacy specialists and coaches are called upon for literacy leadership in schools and often wrestle with the tensions of implementing top-down reforms and making room for teacher- and student-led practices, such as critical literacy. Critical literacy education holds the promise of engaging learners to use literacy practices in ways that matter…

  9. Designing monitoring programs in an adaptive management context for regional multiple species conservation plans

    USGS Publications Warehouse

    Atkinson, A.J.; Trenham, P.C.; Fisher, R.N.; Hathaway, S.A.; Johnson, B.S.; Torres, S.G.; Moore, Y.C.

    2004-01-01

    critical management uncertainties; and 3) implementing long-term monitoring and adaptive management. Ultimately, the success of regional conservation planning depends on the ability of monitoring programs to confront the challenges of adaptively managing and monitoring complex ecosystems and diverse arrays of sensitive species.

  10. Adaptive k-space sampling design for edge-enhanced DCE-MRI using compressed sensing.

    PubMed

    Raja, Rajikha; Sinha, Neelam

    2014-09-01

    The critical challenge in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is the trade-off between spatial and temporal resolution due to the limited availability of acquisition time. To address this, it is imperative to under-sample k-space and to develop specific reconstruction techniques. Our proposed method reconstructs high-quality images from under-sampled dynamic k-space data by proposing two main improvements; i) design of an adaptive k-space sampling lattice and ii) edge-enhanced reconstruction technique. A high-resolution data set obtained before the start of the dynamic phase is utilized. The sampling pattern is designed to adapt to the nature of k-space energy distribution obtained from the static high-resolution data. For image reconstruction, the well-known compressed sensing-based total variation (TV) minimization constrained reconstruction scheme is utilized by incorporating the gradient information obtained from the static high-resolution data. The proposed method is tested on seven real dynamic time series consisting of 2 breast data sets and 5 abdomen data sets spanning 1196 images in all. For data availability of only 10%, performance improvement is seen across various quality metrics. Average improvements in Universal Image Quality Index and Structural Similarity Index Metric of up to 28% and 24% on breast data and about 17% and 9% on abdomen data, respectively, are obtained for the proposed method as against the baseline TV reconstruction with variable density random sampling pattern.

  11. Biomarker-Guided Adaptive Trial Designs in Phase II and Phase III: A Methodological Review

    PubMed Central

    Antoniou, Miranta; Jorgensen, Andrea L; Kolamunnage-Dona, Ruwanthi

    2016-01-01

    Background Personalized medicine is a growing area of research which aims to tailor the treatment given to a patient according to one or more personal characteristics. These characteristics can be demographic such as age or gender, or biological such as a genetic or other biomarker. Prior to utilizing a patient’s biomarker information in clinical practice, robust testing in terms of analytical validity, clinical validity and clinical utility is necessary. A number of clinical trial designs have been proposed for testing a biomarker’s clinical utility, including Phase II and Phase III clinical trials which aim to test the effectiveness of a biomarker-guided approach to treatment; these designs can be broadly classified into adaptive and non-adaptive. While adaptive designs allow planned modifications based on accumulating information during a trial, non-adaptive designs are typically simpler but less flexible. Methods and Findings We have undertaken a comprehensive review of biomarker-guided adaptive trial designs proposed in the past decade. We have identified eight distinct biomarker-guided adaptive designs and nine variations from 107 studies. Substantial variability has been observed in terms of how trial designs are described and particularly in the terminology used by different authors. We have graphically displayed the current biomarker-guided adaptive trial designs and summarised the characteristics of each design. Conclusions Our in-depth overview provides future researchers with clarity in definition, methodology and terminology for biomarker-guided adaptive trial designs. PMID:26910238

  12. Case Studies in Computer Adaptive Test Design through Simulation.

    ERIC Educational Resources Information Center

    Eignor, Daniel R.; And Others

    The extensive computer simulation work done in developing the computer adaptive versions of the Graduate Record Examinations (GRE) Board General Test and the College Board Admissions Testing Program (ATP) Scholastic Aptitude Test (SAT) is described in this report. Both the GRE General and SAT computer adaptive tests (CATs), which are fixed length…

  13. Adaptation Patterns as a Conceptual Tool for Designing the Adaptive Operation of CSCL Systems

    ERIC Educational Resources Information Center

    Karakostas, Anastasios; Demetriadis, Stavros

    2011-01-01

    While adaptive collaboration support has become the focus of increasingly intense research efforts in the CSCL domain, scarce, however, remain the research-based evidence on pedagogically useful ideas on what and how to adapt during the collaborative learning activity. Based principally on two studies, this work presents a compilation of…

  14. An adaptive optics imaging system designed for clinical use.

    PubMed

    Zhang, Jie; Yang, Qiang; Saito, Kenichi; Nozato, Koji; Williams, David R; Rossi, Ethan A

    2015-06-01

    Here we demonstrate a new imaging system that addresses several major problems limiting the clinical utility of conventional adaptive optics scanning light ophthalmoscopy (AOSLO), including its small field of view (FOV), reliance on patient fixation for targeting imaging, and substantial post-processing time. We previously showed an efficient image based eye tracking method for real-time optical stabilization and image registration in AOSLO. However, in patients with poor fixation, eye motion causes the FOV to drift substantially, causing this approach to fail. We solve that problem here by tracking eye motion at multiple spatial scales simultaneously by optically and electronically integrating a wide FOV SLO (WFSLO) with an AOSLO. This multi-scale approach, implemented with fast tip/tilt mirrors, has a large stabilization range of ± 5.6°. Our method consists of three stages implemented in parallel: 1) coarse optical stabilization driven by a WFSLO image, 2) fine optical stabilization driven by an AOSLO image, and 3) sub-pixel digital registration of the AOSLO image. We evaluated system performance in normal eyes and diseased eyes with poor fixation. Residual image motion with incremental compensation after each stage was: 1) ~2-3 arc minutes, (arcmin) 2) ~0.5-0.8 arcmin and, 3) ~0.05-0.07 arcmin, for normal eyes. Performance in eyes with poor fixation was: 1) ~3-5 arcmin, 2) ~0.7-1.1 arcmin and 3) ~0.07-0.14 arcmin. We demonstrate that this system is capable of reducing image motion by a factor of ~400, on average. This new optical design provides additional benefits for clinical imaging, including a steering subsystem for AOSLO that can be guided by the WFSLO to target specific regions of interest such as retinal pathology and real-time averaging of registered images to eliminate image post-processing.

  15. An adaptive optics imaging system designed for clinical use.

    PubMed

    Zhang, Jie; Yang, Qiang; Saito, Kenichi; Nozato, Koji; Williams, David R; Rossi, Ethan A

    2015-06-01

    Here we demonstrate a new imaging system that addresses several major problems limiting the clinical utility of conventional adaptive optics scanning light ophthalmoscopy (AOSLO), including its small field of view (FOV), reliance on patient fixation for targeting imaging, and substantial post-processing time. We previously showed an efficient image based eye tracking method for real-time optical stabilization and image registration in AOSLO. However, in patients with poor fixation, eye motion causes the FOV to drift substantially, causing this approach to fail. We solve that problem here by tracking eye motion at multiple spatial scales simultaneously by optically and electronically integrating a wide FOV SLO (WFSLO) with an AOSLO. This multi-scale approach, implemented with fast tip/tilt mirrors, has a large stabilization range of ± 5.6°. Our method consists of three stages implemented in parallel: 1) coarse optical stabilization driven by a WFSLO image, 2) fine optical stabilization driven by an AOSLO image, and 3) sub-pixel digital registration of the AOSLO image. We evaluated system performance in normal eyes and diseased eyes with poor fixation. Residual image motion with incremental compensation after each stage was: 1) ~2-3 arc minutes, (arcmin) 2) ~0.5-0.8 arcmin and, 3) ~0.05-0.07 arcmin, for normal eyes. Performance in eyes with poor fixation was: 1) ~3-5 arcmin, 2) ~0.7-1.1 arcmin and 3) ~0.07-0.14 arcmin. We demonstrate that this system is capable of reducing image motion by a factor of ~400, on average. This new optical design provides additional benefits for clinical imaging, including a steering subsystem for AOSLO that can be guided by the WFSLO to target specific regions of interest such as retinal pathology and real-time averaging of registered images to eliminate image post-processing. PMID:26114033

  16. Design and responses of Butterworth and critically damped digital filters.

    PubMed

    Robertson, D Gordon E; Dowling, James J

    2003-12-01

    For many years the Butterworth lowpass filter has been used to smooth many kinds of biomechanical data, despite the fact that it is underdamped and therefore overshoots and/or undershoots data during rapid transitions. A comparison of the conventional Butterworth filter with a critically damped filter shows that the critically damped filter not only removes the undershooting and overshooting, but has a superior rise time during rapid transitions. While analog filters always create phase distortion, both the critically damped and Butterworth filters can be modified to become zero-lag filters when the data are processed in both the forward and reverse directions. In such cases little improvement is realized by applying multiple passes. The Butterworth filter has superior 'roll-off' (attenuation of noise above the cutoff frequency) than the critically damped filter, but by increasing the number of passes of the critically damped filter the same 'roll-off' can be achieved. In summary, the critically damped filter was shown to have superior performance in the time domain than the Butterworth filter, but for data that need to be double differentiated (e.g. displacement data) the Butterworth filter may still be the better choice.

  17. Time domain and frequency domain design techniques for model reference adaptive control systems

    NASA Technical Reports Server (NTRS)

    Boland, J. S., III

    1971-01-01

    Some problems associated with the design of model-reference adaptive control systems are considered and solutions to these problems are advanced. The stability of the adapted system is a primary consideration in the development of both the time-domain and the frequency-domain design techniques. Consequentially, the use of Liapunov's direct method forms an integral part of the derivation of the design procedures. The application of sensitivity coefficients to the design of model-reference adaptive control systems is considered. An application of the design techniques is also presented.

  18. Skylab Earth Resource Experiment Package critical design review. [conference

    NASA Technical Reports Server (NTRS)

    1973-01-01

    An outline of the conference for reviewing the design of the EREP is presented. Systems design for review include: tape recorder, support equipment, view finder/tracking, support hardware, and control and display panel.

  19. Critical Bifocality and Circuits of Privilege: Expanding Critical Ethnographic Theory and Design

    ERIC Educational Resources Information Center

    Weis, Lois; Fine, Michelle

    2012-01-01

    In this article, Lois Weis and Michelle Fine introduce critical bifocality as a way to render visible the relations between groups to structures of power, to social policies, to history, and to large sociopolitical formations. In this collaboration, the authors draw upon ethnographic examples highlighting the macro-level structural dynamics…

  20. Critical by Design: Enacting Critical Action Learning in a Small Business Context

    ERIC Educational Resources Information Center

    Ram, Monder; Trehan, Kiran

    2009-01-01

    A small but growing strand of literature is beginning to make the case for "critical action learning" (CAL). Much of this interest operates on theoretical terrain, speculating on the extent to which it might differ from more conventional notions of action learning. This paper draws on insights from (CAL) to demonstrate the importance of being…

  1. Adapting Dam and Reservoir Design and Operations to Climate Change

    NASA Astrophysics Data System (ADS)

    Roy, René; Braun, Marco; Chaumont, Diane

    2013-04-01

    In order to identify the potential initiatives that the dam, reservoir and water resources systems owners and operators may undertake to cope with climate change issues, it is essential to determine the current state of knowledge of their impacts on hydrological variables at regional and local scales. Future climate scenarios derived from climate model simulations can be combined with operational hydrological modeling tools and historical observations to evaluate realistic pathways of future hydrological conditions for specific drainage basins. In the case of hydropower production those changes in hydrological conditions may have significant economic impacts. For over a decade the state owned hydropower producer Hydro Québec has been exploring the physical impacts on their watersheds by relying on climate services in collaboration with Ouranos, a consortium on regional climatology and adaptation to climate change. Previous climate change impact analysis had been including different sources of climate simulation data, explored different post-processing approaches and used hydrological impact models. At a new stage of this collaboration the operational management of Hydro Quebec aspired to carry out a cost-benefit analysis of considering climate change in the refactoring of hydro-power installations. In the process of the project not only a set of scenarios of future runoff regimes had to be defined to support long term planning decisions of a dam and reservoir operator, but also the significance of uncertainties needed to be communicated and made understood. We provide insight into a case study that took some unexpected turns and leaps by bringing together climate scientists, hydrologists and hydro-power operation managers. The study includes the selection of appropriate climate scenarios, the correction of biases, the application of hydrological models and the assessment of uncertainties. However, it turned out that communicating the science properly and

  2. 76 FR 9871 - Endangered and Threatened Wildlife and Plants; Designation of Critical Habitat for Nine Bexar...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-22

    ... County karst invertebrates. We published a final listing rule on December 26, 2000 (65 FR 81419). In the... as critical habitat for the 9 karst invertebrates (67 FR 55063). The final critical habitat rule..., 2000 (65 FR 81419), the proposed critical habitat designation published August 27, 2002 (67 FR...

  3. 78 FR 65959 - Proposed Designation of Marine Critical Habitat for the Loggerhead Sea Turtle, Caretta caretta...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-04

    ... Marine Critical Habitat for the Loggerhead Sea Turtle, Caretta caretta, Under the Endangered Species Act... related to our Proposed Designation of Marine Critical Habitat for the Loggerhead Sea Turtle, Caretta... Critical Habitat for the Northwest Atlantic Ocean Loggerhead Sea Turtle Distinct Population Segment...

  4. 77 FR 18157 - Endangered and Threatened Wildlife and Plants; Designation of Critical Habitat for Ipomopsis...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-27

    ... proposed designation of critical habitat published in the Federal Register on July 27, 2011 (76 FR 45078... threatened (76 FR 45054); as well as the July 27, 2011 proposed critical habitat rule (76 FR 45078). Section... critical habitat rule still applies (76 FR 45078). Unit 4. Eight Mile Mesa We are proposing to reduce...

  5. Learning Experiences to Develop Critical Thinking through Understanding by Design

    ERIC Educational Resources Information Center

    Williams, David; Williams, Margot

    2009-01-01

    In some classrooms, gifted students are not exposed to the large and complex body of information and knowledge available today; instead, they are limited to what is deemed appropriate for the majority of their classmates. As a result, capable bright students may not develop the critical thinking skills necessary to analyze, synthesize, and…

  6. Interpretive and Critical Phenomenological Crime Studies: A Model Design

    ERIC Educational Resources Information Center

    Miner-Romanoff, Karen

    2012-01-01

    The critical and interpretive phenomenological approach is underutilized in the study of crime. This commentary describes this approach, guided by the question, "Why are interpretive phenomenological methods appropriate for qualitative research in criminology?" Therefore, the purpose of this paper is to describe a model of the interpretive…

  7. Combining Critical Reflection and Design Thinking to Develop Integrative Learners

    ERIC Educational Resources Information Center

    Welsh, M. Ann; Dehler, Gordon E.

    2013-01-01

    In this article, we argue for advancing grounded curricula, which explicitly link theory and pedagogy, and executing them in authentic and multidisciplinary settings as a means to facilitate student growth into integrative learners. We describe the development of a student-centered learning experience that combines elements of critical management…

  8. The Design of a Critical Thinking Test on Appraising Observations. Studies in Critical Thinking, Research Report No. 1.

    ERIC Educational Resources Information Center

    Norris, Stephen P.; King, Ruth

    This report describes the design of a test of one aspect of critical thinking ability, the ability to correctly appraise observations. Intended for classroom use with senior high school students, the 50 item Test on Appraising Observations is based on a comprehensive set of principles modified from Robert Ennes' conception of good observation…

  9. Toolbox or Adjustable Spanner? A Critical Comparison of Two Metaphors for Adaptive Decision Making

    ERIC Educational Resources Information Center

    Söllner, Anke; Bröder, Arndt

    2016-01-01

    For multiattribute decision tasks, different metaphors exist that describe the process of decision making and its adaptation to diverse problems and situations. Multiple strategy models (MSMs) assume that decision makers choose adaptively from a set of different strategies (toolbox metaphor), whereas evidence accumulation models (EAMs) hold that a…

  10. 76 FR 66805 - Endangered and Threatened Wildlife and Plants: Final Rulemaking To Designate Critical Habitat for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-27

    ... or a significant portion of its range and listed the species as endangered under the ESA (74 FR 1937). We issued a proposed critical habitat designation for the black abalone on September 28, 2010 (75 FR... Biological Report (NMFS 2011a) and in the proposed rule to designate critical habitat (75 FR 59900;...

  11. 78 FR 59907 - Endangered and Threatened Species: Proposed Rule To Designate Critical Habitat for the Northwest...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-30

    ...: Proposed Rule To Designate Critical Habitat for the Northwest Atlantic Ocean Loggerhead Sea Turtle Distinct... the Federal Register a proposed rule to designate critical habitat for the Northwest Atlantic Ocean loggerhead sea turtle Distinct Population Segment (DPS) (Caretta caretta) within the Atlantic Ocean and...

  12. 78 FR 39237 - Endangered and Threatened Wildlife and Plants; Designation of Critical Habitat for the Jaguar

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-01

    ... published a proposed rule to designate critical habitat for the jaguar (77 FR 50214). In that proposed rule... Federal Register a proposed rule to designate critical habitat for the jaguar (77 FR 50214). We based the..., 2012 (77 FR 50214), is reopened. We will consider comments received or postmarked on or before August...

  13. 75 FR 27690 - Endangered and Threatened Wildlife and Plants; Designation of Critical Habitat for Ambrosia...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-18

    ... habitat rule (74 FR 44246, August 27, 2009)). ] (5) Land use designations and current or planned... INFORMATION CONTACT). You may obtain copies of the original proposed designation of critical habitat (74 FR... ac (324 ha) that we proposed as critical habitat on August 27, 2009 (74 FR 44238), bringing the...

  14. 78 FR 51705 - Endangered and Threatened Wildlife and Plants; Designation of Critical Habitat for Ivesia webberi

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-21

    ...; Designation of Critical Habitat for Ivesia webberi (Webber's ivesia) AGENCY: Fish and Wildlife Service... habitat for Ivesia webberi. DATES: We will hold a public meeting on the proposed rule on September 10... INFORMATION: In our August 2, 2013, proposed rule to designate critical habitat for Ivesia webberi,...

  15. 75 FR 77817 - Endangered and Threatened Wildlife and Plants; Designation of Critical Habitat for Mississippi...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-14

    ... Register on June 3, 2010 (75 FR 31387), the DEA of the proposed designation of critical habitat for the... frog (75 FR 31387). We proposed to designate as critical habitat a total of 792 hectares (1,957 acres... on the proposed rule (75 FR 31387) during the initial comment period from June 3, 2010, to August...

  16. 76 FR 39807 - Endangered and Threatened Wildlife and Plants; Designation of Critical Habitat for Lepidium...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-07

    ..., we listed Lepidium papilliferum as a threatened species on October 8, 2009 (74 FR 52014). On May 10, 2011, we published the proposed designation of critical habitat for L. papilliferum (76 FR 27184). All...; Designation of Critical Habitat for Lepidium papilliferum (Slickspot Peppergrass) AGENCY: Fish and...

  17. 75 FR 61690 - Endangered and Threatened Wildlife and Designating Critical Habitat for the Endangered North...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-06

    ... glacialis) to consist of two populations--one occurring in the North Atlantic Ocean and the other in the... Atlantic Ocean (59 FR 28805; June 3, 1994). This critical habitat designation includes portions of Cape Cod... only areas in the North Atlantic Ocean. The population analyzed in the critical habitat designation...

  18. Adaptation of the quality by design concept in early pharmaceutical development of an intranasal nanosized formulation.

    PubMed

    Pallagi, Edina; Ambrus, Rita; Szabó-Révész, Piroska; Csóka, Ildikó

    2015-08-01

    Regulatory science based pharmaceutical development and product manufacturing is highly recommended by the authorities nowadays. The aim of this study was to adapt regulatory science even in the nano-pharmaceutical early development. Authors applied the quality by design (QbD) concept in the early development phase of nano-systems, where the illustration material was meloxicam. The meloxicam nanoparticles produced by co-grinding method for nasal administration were studied according to the QbD policy and the QbD based risk assessment (RA) was performed. The steps were implemented according to the relevant regulatory guidelines (quality target product profile (QTPP) determination, selection of critical quality attributes (CQAs) and critical process parameters (CPPs)) and a special software (Lean QbD Software(®)) was used for the RA, which represents a novelty in this field. The RA was able to predict and identify theoretically the factors (e.g. sample composition, production method parameters, etc.) which have the highest impact on the desired meloxicam-product quality. The results of the practical research justified the theoretical prediction. This method can improve pharmaceutical nano-developments by achieving shorter development time, lower cost, saving human resource efforts and more effective target-orientation. It makes possible focusing the resources on the selected parameters and area during the practical product development. PMID:26134895

  19. Adaptation of the quality by design concept in early pharmaceutical development of an intranasal nanosized formulation.

    PubMed

    Pallagi, Edina; Ambrus, Rita; Szabó-Révész, Piroska; Csóka, Ildikó

    2015-08-01

    Regulatory science based pharmaceutical development and product manufacturing is highly recommended by the authorities nowadays. The aim of this study was to adapt regulatory science even in the nano-pharmaceutical early development. Authors applied the quality by design (QbD) concept in the early development phase of nano-systems, where the illustration material was meloxicam. The meloxicam nanoparticles produced by co-grinding method for nasal administration were studied according to the QbD policy and the QbD based risk assessment (RA) was performed. The steps were implemented according to the relevant regulatory guidelines (quality target product profile (QTPP) determination, selection of critical quality attributes (CQAs) and critical process parameters (CPPs)) and a special software (Lean QbD Software(®)) was used for the RA, which represents a novelty in this field. The RA was able to predict and identify theoretically the factors (e.g. sample composition, production method parameters, etc.) which have the highest impact on the desired meloxicam-product quality. The results of the practical research justified the theoretical prediction. This method can improve pharmaceutical nano-developments by achieving shorter development time, lower cost, saving human resource efforts and more effective target-orientation. It makes possible focusing the resources on the selected parameters and area during the practical product development.

  20. Mobile healthcare applications: system design review, critical issues and challenges.

    PubMed

    Baig, Mirza Mansoor; GholamHosseini, Hamid; Connolly, Martin J

    2015-03-01

    Mobile phones are becoming increasingly important in monitoring and delivery of healthcare interventions. They are often considered as pocket computers, due to their advanced computing features, enhanced preferences and diverse capabilities. Their sophisticated sensors and complex software applications make the mobile healthcare (m-health) based applications more feasible and innovative. In a number of scenarios user-friendliness, convenience and effectiveness of these systems have been acknowledged by both patients as well as healthcare providers. M-health technology employs advanced concepts and techniques from multidisciplinary fields of electrical engineering, computer science, biomedical engineering and medicine which benefit the innovations of these fields towards healthcare systems. This paper deals with two important aspects of current mobile phone based sensor applications in healthcare. Firstly, critical review of advanced applications such as; vital sign monitoring, blood glucose monitoring and in-built camera based smartphone sensor applications. Secondly, investigating challenges and critical issues related to the use of smartphones in healthcare including; reliability, efficiency, mobile phone platform variability, cost effectiveness, energy usage, user interface, quality of medical data, and security and privacy. It was found that the mobile based applications have been widely developed in recent years with fast growing deployment by healthcare professionals and patients. However, despite the advantages of smartphones in patient monitoring, education, and management there are some critical issues and challenges related to security and privacy of data, acceptability, reliability and cost that need to be addressed.

  1. Mobile healthcare applications: system design review, critical issues and challenges.

    PubMed

    Baig, Mirza Mansoor; GholamHosseini, Hamid; Connolly, Martin J

    2015-03-01

    Mobile phones are becoming increasingly important in monitoring and delivery of healthcare interventions. They are often considered as pocket computers, due to their advanced computing features, enhanced preferences and diverse capabilities. Their sophisticated sensors and complex software applications make the mobile healthcare (m-health) based applications more feasible and innovative. In a number of scenarios user-friendliness, convenience and effectiveness of these systems have been acknowledged by both patients as well as healthcare providers. M-health technology employs advanced concepts and techniques from multidisciplinary fields of electrical engineering, computer science, biomedical engineering and medicine which benefit the innovations of these fields towards healthcare systems. This paper deals with two important aspects of current mobile phone based sensor applications in healthcare. Firstly, critical review of advanced applications such as; vital sign monitoring, blood glucose monitoring and in-built camera based smartphone sensor applications. Secondly, investigating challenges and critical issues related to the use of smartphones in healthcare including; reliability, efficiency, mobile phone platform variability, cost effectiveness, energy usage, user interface, quality of medical data, and security and privacy. It was found that the mobile based applications have been widely developed in recent years with fast growing deployment by healthcare professionals and patients. However, despite the advantages of smartphones in patient monitoring, education, and management there are some critical issues and challenges related to security and privacy of data, acceptability, reliability and cost that need to be addressed. PMID:25476753

  2. An Automatic Online Calibration Design in Adaptive Testing

    ERIC Educational Resources Information Center

    Makransky, Guido; Glas, Cees A. W.

    2010-01-01

    An accurately calibrated item bank is essential for a valid computerized adaptive test. However, in some settings, such as occupational testing, there is limited access to test takers for calibration. As a result of the limited access to possible test takers, collecting data to accurately calibrate an item bank in an occupational setting is…

  3. Design of a Computer-Adaptive Test to Measure English Literacy and Numeracy in the Singapore Workforce: Considerations, Benefits, and Implications

    ERIC Educational Resources Information Center

    Jacobsen, Jared; Ackermann, Richard; Eguez, Jane; Ganguli, Debalina; Rickard, Patricia; Taylor, Linda

    2011-01-01

    A computer adaptive test (CAT) is a delivery methodology that serves the larger goals of the assessment system in which it is embedded. A thorough analysis of the assessment system for which a CAT is being designed is critical to ensure that the delivery platform is appropriate and addresses all relevant complexities. As such, a CAT engine must be…

  4. Optical System Critical Design Review (CDR) Flight Software Summary

    NASA Technical Reports Server (NTRS)

    Khorrami, Mori

    2006-01-01

    The Mid Infrared Instrument (MIRI FSW presentation covers: (1) Optical System FSW only and Cooling System FSW is covered at its CDR (2) Requirements & Interfaces (3) Relationship with the ISIM FSW (4) FSW Design Drivers & Solutions.

  5. Critical requirements for the design of large space structures

    NASA Technical Reports Server (NTRS)

    Hedgepeth, J. M.

    1981-01-01

    The requirements for the design of a large space structure which will be deployed, erected, assembled or fabricated in space are delineated in terms of operational loads, stiffness requirements, structure-control interaction, deformations, precision requirements and member slenderness. Design examples for a truss antenna reflector, interorbit propulsion loads and free-flying solar reflectors are given. It is concluded that the demand for dimensional accuracy and stability form the primary requirements.

  6. Designing Critical Experiments in Support of Full Burnup Credit

    SciTech Connect

    Mueller, Don; Roberts, Jeremy A

    2008-01-01

    Burnup credit is the process of accounting for the negative reactivity due to fuel burnup and generation of parasitic absorbers over fuel assembly lifetime. For years, the fresh fuel assumption was used as a simple bound in criticality work for used fuel storage and transportation. More recently, major actinides have been included [1]. However, even this yields a highly conservative estimate in criticality calculations. Because of the numerous economical benefits including all available negative reactivity (i.e., full burnup credit) could provide [2], it is advantageous to work toward full burnup credit. Unfortunately, comparatively little work has been done to include non-major actinides and other fission products (FP) in burnup credit analyses due in part to insufficient experimental data for validation of codes and nuclear data. The Burnup Credit Criticality Experiment (BUCCX) at Sandia National Laboratory was a set of experiments with {sup 103}Rh that have relevance for burnup credit [3]. This work uses TSUNAMI-3D to investigate and adjust a BUCCX model to match isotope-specific, energy-dependent k{sub eff} sensitivity profiles to those of a representative high-capacity cask model (GBC-32) [4] for each FP of interest. The isotopes considered are {sup 149}Sm, {sup 143}Nd, {sup 103}Rh, {sup 133}Cs, {sup 155}Gd, {sup 152}Sm, {sup 99}Tc, {sup 145}Nd, {sup 153}Eu, {sup 147}Sm, {sup 109}Ag, {sup 95}Mo, {sup 150}Sm, {sup 101}Ru, and {sup 151}Eu. The goal is to understand the biases and bias uncertainties inherent in nuclear data, and ultimately, to apply these in support of full burnup credit.

  7. High-power FEL design issues - a critical review

    SciTech Connect

    Litvinenko, V.N.; Madey, J.M.J.; O`Shea, P.G.

    1995-12-31

    The high-average power capability of FELs has been much advertised but little realized. In this paper we provide a critical analysis of the technological and economic issues associated with high-average power FEL operation from the UV to near IR. The project of IR FEL for the Siberian Center of photochemical researches is described. The distinguished features of this project are the use of the race-track microtron-recuperator and the {open_quotes}electron output of radiation{close_quotes}. The building for the machine is under reconstruction now. About half of hardware has been manufactured. The assembly of installation began.

  8. Context-Adaptive Learning Designs by Using Semantic Web Services

    ERIC Educational Resources Information Center

    Dietze, Stefan; Gugliotta, Alessio; Domingue, John

    2007-01-01

    IMS Learning Design (IMS-LD) is a promising technology aimed at supporting learning processes. IMS-LD packages contain the learning process metadata as well as the learning resources. However, the allocation of resources--whether data or services--within the learning design is done manually at design-time on the basis of the subjective appraisals…

  9. A mathematical basis for the design and design optimization of adaptive trusses in precision control

    NASA Technical Reports Server (NTRS)

    Das, S. K.; Utku, S.; Chen, G.-S.; Wada, B. K.

    1991-01-01

    A mathematical basis for the optimal design of adaptive trusses to be used in supporting precision equipment is provided. The general theory of adaptive structures is introduced, and the global optimization problem of placing a limited number, q, of actuators, so as to maximally achieve precision control and provide prestress, is stated. Two serialized optimization problems, namely, optimal actuator placement for prestress and optimal actuator placement for precision control, are addressed. In the case of prestressing, the computation of a 'desired' prestress is discussed, the interaction between actuators and redundants in conveying the prestress is shown in its mathematical form, and a methodology for arriving at the optimal placement of actuators and additional redundants is discussed. With regard to precision control, an optimal placement scheme (for q actuators) for maximum 'authority' over the precision points is suggested. The results of the two serialized optimization problems are combined to give a suboptimal solution to the global optimization problem. A method for improving this suboptimal actuator placement scheme by iteration is presented.

  10. Decentralized adaptive control of robot manipulators with robust stabilization design

    NASA Technical Reports Server (NTRS)

    Yuan, Bau-San; Book, Wayne J.

    1988-01-01

    Due to geometric nonlinearities and complex dynamics, a decentralized technique for adaptive control for multilink robot arms is attractive. Lyapunov-function theory for stability analysis provides an approach to robust stabilization. Each joint of the arm is treated as a component subsystem. The adaptive controller is made locally stable with servo signals including proportional and integral gains. This results in the bound on the dynamical interactions with other subsystems. A nonlinear controller which stabilizes the system with uniform boundedness is used to improve the robustness properties of the overall system. As a result, the robot tracks the reference trajectories with convergence. This strategy makes computation simple and therefore facilitates real-time implementation.

  11. Biomimetic rules for design of complex adaptive structures

    NASA Astrophysics Data System (ADS)

    Dry, Carolyn M.

    2001-10-01

    Nature builds by 1) use of local, inexpensive, available often recycled materials which 2) are self-ordering or growing by attributes shared between the material and environment, 3) repair themselves, 4) sense and adapt to changes in the environment daily, seasonally, and yearly; 5) easily disintegrate and recycle back into the material sink when their usefulness is at an end; and 6) do not harm the environment, but perhaps enhance it or resolve problems.

  12. Designs for surge immunity in critical electronic facilities

    NASA Astrophysics Data System (ADS)

    Roberts, Edward F., Jr.

    1991-08-01

    In recent years, Federal Aviation Administration (FAA) embarked on a program replacing older tube type electronic equipment with newer solid state equipment. This replacement program dramatically increased the susceptibility of the FAA's facilities to lightning related damages. The proposal is presented of techniques which may be employed to lessen the susceptibility of new FAA electronic facility designs to failures resulting from lightning related surges and transients as well as direct strikes. The general concept espoused is one of a consistent system approach employing both perimeter and internal protection. It compares the technique presently employed to reduce electronic noise with other techniques which reduce noise while lowering susceptibility to lightning related damage. It is anticipated that these techniques will be employed in the design of an Air Traffic Control Tower in a high isokeraunic area. This facility would be subjected to rigorous monitoring over a multi-year period to provide quantitative data hopefully supporting the advantage of this design.

  13. Designs for surge immunity in critical electronic facilities

    NASA Technical Reports Server (NTRS)

    Roberts, Edward F., Jr.

    1991-01-01

    In recent years, Federal Aviation Administration (FAA) embarked on a program replacing older tube type electronic equipment with newer solid state equipment. This replacement program dramatically increased the susceptibility of the FAA's facilities to lightning related damages. The proposal is presented of techniques which may be employed to lessen the susceptibility of new FAA electronic facility designs to failures resulting from lightning related surges and transients as well as direct strikes. The general concept espoused is one of a consistent system approach employing both perimeter and internal protection. It compares the technique presently employed to reduce electronic noise with other techniques which reduce noise while lowering susceptibility to lightning related damage. It is anticipated that these techniques will be employed in the design of an Air Traffic Control Tower in a high isokeraunic area. This facility would be subjected to rigorous monitoring over a multi-year period to provide quantitative data hopefully supporting the advantage of this design.

  14. The Optical Design of the Human Eye: a Critical Review

    PubMed Central

    Navarro, Rafael

    2010-01-01

    Cornea, lens and eye models are analyzed and compared to experimental findings to assess properties and eventually unveil optical design principles involved in the structure and function of the optical system of the eye. Models and data often show good match but also some paradoxes. The optical design seems to correspond to a wide angle lens. Compared to conventional optical systems, the eye presents a poor optical quality on axis, but a relatively good quality off-axis, thus yielding higher homogeneity for a wide visual field. This seems the result of an intriguing combination of the symmetry design principle with a total lack of rotational symmetry, decentrations and misalignments of the optical surfaces.

  15. Adapting Critical Incident Stress Management to the Schools: A Multi-Agency Approach

    ERIC Educational Resources Information Center

    Tortorici, Joanne; Johnson, Luna Kendall

    2004-01-01

    The need for school-appropriate applications of critical incident stress management (CISM) is noted in the literature on school crisis response. This paper presents preliminary data suggesting a School Crisis Response Team's (SCRT) usage and team needs. The SCRT was dispatched for a variety of critical incidents. Self-dispatch, followed by…

  16. On efficient two-stage adaptive designs for clinical trials with sample size adjustment.

    PubMed

    Liu, Qing; Li, Gang; Anderson, Keaven M; Lim, Pilar

    2012-01-01

    Group sequential designs are rarely used for clinical trials with substantial over running due to fast enrollment or long duration of treatment and follow-up. Traditionally, such trials rely on fixed sample size designs. Recently, various two-stage adaptive designs have been introduced to allow sample size adjustment to increase statistical power or avoid unnecessarily large trials. However, these adaptive designs can be seriously inefficient. To address this infamous problem, we propose a likelihood-based two-stage adaptive design where sample size adjustment is derived from a pseudo group sequential design using cumulative conditional power. We show through numerical examples that this design cannot be improved by group sequential designs. In addition, the approach may uniformly improve any existing two-stage adaptive designs with sample size adjustment. For statistical inference, we provide methods for sequential p-values and confidence intervals, as well as median unbiased and minimum variance unbiased estimates. We show that the claim of inefficiency of adaptive designs by Tsiatis and Mehta ( 2003 ) is logically flawed, and thereby provide a strong defense of Cui et al. ( 1999 ). PMID:22651105

  17. The Adaptation of Four Year Undergraduate Colleges to Current Fiscal and Enrollment Pressures: An Exploration of Critical Event Cycles at Seventeen Campuses. ASHE 1983 Annual Meeting Paper.

    ERIC Educational Resources Information Center

    Finkelstein, Martin; Farrar, David

    The results of analyzing institutional change profiles for 17 four-year undergraduate colleges are discussed. Using critical event cycles as a unit of analysis, attention was focused on distinctive patterns of institutional adaptation. Based on site visits, a list of 33 critical events at the 17 campuses was developed, from which 13 critical event…

  18. A Web-Based Adaptive Tutor to Teach PCR Primer Design

    ERIC Educational Resources Information Center

    van Seters, Janneke R.; Wellink, Joan; Tramper, Johannes; Goedhart, Martin J.; Ossevoort, Miriam A.

    2012-01-01

    When students have varying prior knowledge, personalized instruction is desirable. One way to personalize instruction is by using adaptive e-learning to offer training of varying complexity. In this study, we developed a web-based adaptive tutor to teach PCR primer design: the PCR Tutor. We used part of the Taxonomy of Educational Objectives (the…

  19. Designing Automated Adaptive Support to Improve Student Helping Behaviors in a Peer Tutoring Activity

    ERIC Educational Resources Information Center

    Walker, Erin; Rummel, Nikol; Koedinger, Kenneth R.

    2011-01-01

    Adaptive collaborative learning support systems analyze student collaboration as it occurs and provide targeted assistance to the collaborators. Too little is known about how to design adaptive support to have a positive effect on interaction and learning. We investigated this problem in a reciprocal peer tutoring scenario, where two students take…

  20. Determination of critical anthropometric parameters for design of respirators

    SciTech Connect

    You-Hin Liau

    1982-12-01

    Anthropometric data were collected from 243 workers in a respirator fit-test programme, and an attempt was made to determine a correlation between these data and the Protection Factor obtained from quantitative fit-testing for half-mask respirators. Data were collected for two direct and five indirect facial measurements from front- and side-view slides of test subjects. For analysis, the data were normalized with relevant respirators dimensions (4 brands and 10 sizes). Results of linear regression analysis indicated that correlation coefficients between Protection Factor and anthropometric data (face length, mouth width, face width, nasal root breadth) were, respectively, 0.04, 0.22, 0.30 and 0.04. These correlation coefficients are for white males without facial hair. The analysis showed the 'critical' parameters to be mouth width and face width; however, a person with certain combinations of anthropometric parameters may provide a better correlation with Protection Factor.

  1. Error Gravity: A Critical Review of Research Design.

    ERIC Educational Resources Information Center

    Rifkin, Benjamin; Roberts, Felicia D.

    1995-01-01

    Examines error gravity research design and its theoretical assumptions. Results indicate that investigators have only skimmed the surface of the process of error evaluation, which is shaped by extralinguistic factors. The article concludes that researchers should reconceptualize error gravity research and reassess earlier studies to confirm or…

  2. In search of a course design and teaching methods to improve critical thinking skills.

    PubMed

    Simendinger, Earl

    2003-01-01

    This article describes a unique course design to teach critical thinking skills to students in formal academic degree programs preparing to become healthcare administrators. The course and its experimental design were motivated by several factors. First, intelligent and competent problem solving and decision making, most would agree, are directly dependent on critical thinking proficiency. Therefore, elevating students' critical-thinking competence will inherently improve their problem-solving and decision-making ability. Second, problem solving and decision making consumes the majority of an administrator's time. And finally, a review of AUPHA's catalog descriptions of healthcare graduate curriculums listrelatively few critical-thinking courses compared to the time administrators devote to it.

  3. Design of fuzzy system by NNs and realization of adaptability

    NASA Technical Reports Server (NTRS)

    Takagi, Hideyuki

    1993-01-01

    The issue of designing and tuning fuzzy membership functions by neural networks (NN's) was started by NN-driven Fuzzy Reasoning in 1988. NN-driven fuzzy reasoning involves a NN embedded in the fuzzy system which generates membership values. In conventional fuzzy system design, the membership functions are hand-crafted by trial and error for each input variable. In contrast, NN-driven fuzzy reasoning considers several variables simultaneously and can design a multidimensional, nonlinear membership function for the entire subspace.

  4. Response-adaptive decision-theoretic trial design: operating characteristics and ethics.

    PubMed

    Lipsky, Ari M; Lewis, Roger J

    2013-09-20

    Adaptive randomization is used in clinical trials to increase statistical efficiency. In addition, some clinicians and researchers believe that using adaptive randomization leads necessarily to more ethical treatment of subjects in a trial. We develop Bayesian, decision-theoretic, clinical trial designs with response-adaptive randomization and a primary goal of estimating treatment effect and then contrast these designs with designs that also include in their loss function a cost for poor subject outcome. When the loss function did not incorporate a cost for poor subject outcome, the gains in efficiency from response-adaptive randomization were accompanied by ethically concerning subject allocations. Conversely, including a cost for poor subject outcome demonstrated a more acceptable balance between the competing needs in the trial. A subsequent, parallel set of trials designed to control explicitly types I and II error rates showed that much of the improvement achieved through modification of the loss function was essentially negated. Therefore, gains in efficiency from the use of a decision-theoretic, response-adaptive design using adaptive randomization may only be assumed to apply to those goals that are explicitly included in the loss function. Trial goals, including ethical ones, which do not appear in the loss function, are ignored and may even be compromised; it is thus inappropriate to assume that all adaptive trials are necessarily more ethical. Controlling types I and II error rates largely negates the benefit of including competing needs in favor of the goal of parameter estimation.

  5. Aircraft conceptual design - an adaptable parametric sizing methodology

    NASA Astrophysics Data System (ADS)

    Coleman, Gary John, Jr.

    Aerospace is a maturing industry with successful and refined baselines which work well for traditional baseline missions, markets and technologies. However, when new markets (space tourism) or new constrains (environmental) or new technologies (composite, natural laminar flow) emerge, the conventional solution is not necessarily best for the new situation. Which begs the question "how does a design team quickly screen and compare novel solutions to conventional solutions for new aerospace challenges?" The answer is rapid and flexible conceptual design Parametric Sizing. In the product design life-cycle, parametric sizing is the first step in screening the total vehicle in terms of mission, configuration and technology to quickly assess first order design and mission sensitivities. During this phase, various missions and technologies are assessed. During this phase, the designer is identifying design solutions of concepts and configurations to meet combinations of mission and technology. This research undertaking contributes the state-of-the-art in aircraft parametric sizing through (1) development of a dedicated conceptual design process and disciplinary methods library, (2) development of a novel and robust parametric sizing process based on 'best-practice' approaches found in the process and disciplinary methods library, and (3) application of the parametric sizing process to a variety of design missions (transonic, supersonic and hypersonic transports), different configurations (tail-aft, blended wing body, strut-braced wing, hypersonic blended bodies, etc.), and different technologies (composite, natural laminar flow, thrust vectored control, etc.), in order to demonstrate the robustness of the methodology and unearth first-order design sensitivities to current and future aerospace design problems. This research undertaking demonstrates the importance of this early design step in selecting the correct combination of mission, technologies and configuration to

  6. Critical early mission design considerations for lunar data systems architecture

    NASA Technical Reports Server (NTRS)

    Hei, Donald J., Jr.; Stephens, Elaine

    1992-01-01

    This paper outlines recent early mission design activites for a lunar data systems architecture. Each major functional element is shown to be strikingly similar when viewed in a common reference system. While this similarity probably deviates with lower levels of decomposition, the sub-functions can always be arranged into similar and dissimilar categories. Similar functions can be implemented as objects - implemented once and reused several times like today's advanced integrated circuits. This approach to mission data systems, applied to other NASA programs, may result in substantial agency implementation and maintenance savings. In today's zero-sum-game budgetary environment, this approach could help to enable a lunar exploration program in the next decade. Several early mission studies leading to such an object-oriented data systems design are recommended.

  7. Adapting Cognitive Walkthrough to Support Game Based Learning Design

    ERIC Educational Resources Information Center

    Farrell, David; Moffat, David C.

    2014-01-01

    For any given Game Based Learning (GBL) project to be successful, the player must learn something. Designers may base their work on pedagogical research, but actual game design is still largely driven by intuition. People are famously poor at unsupported methodical thinking and relying so much on instinct is an obvious weak point in GBL design…

  8. Adapting the Mathematical Task Framework to Design Online Didactic Objects

    ERIC Educational Resources Information Center

    Bowers, Janet; Bezuk, Nadine; Aguilar, Karen

    2011-01-01

    Designing didactic objects involves imagining how students can conceive of specific mathematical topics and then imagining what types of classroom discussions could support these mental constructions. This study investigated whether it was possible to design Java applets that might serve as didactic objects to support online learning where…

  9. ADAPT[IT]: Tools for Training Design and Evaluation.

    ERIC Educational Resources Information Center

    de Croock, Marcel B. M.; Paas, Fred; Schlanbusch, Henrik; van Merrienboer, Jeroen J. G.

    2002-01-01

    Describes a set of computerized tools that support the instructional design and evaluation of competency-based training programs. Discusses authentic whole-task practice situations; the 4C/ID* methodology; an evaluation tool that supports the subsequent revision of the competency-based training design; and future plans. (Author/LRW)

  10. Adapting the mathematical task framework to design online didactic objects

    NASA Astrophysics Data System (ADS)

    Bowers, Janet; Bezuk, Nadine; Aguilar, Karen

    2011-06-01

    Designing didactic objects involves imagining how students can conceive of specific mathematical topics and then imagining what types of classroom discussions could support these mental constructions. This study investigated whether it was possible to design Java applets that might serve as didactic objects to support online learning where 'discussions' are broadly defined as the conversations students have with themselves as they interact with the dynamic mathematical representations on the screen. Eighty-four pre-service elementary teachers enrolled in hybrid mathematics courses were asked to interact with a series of applets designed to support their understanding of qualitative graphing. The results of the surveys indicate that various design features of the applets did in fact cause perturbations and opportunities for resolutions that enabled the users to 'discuss' their learning by reflecting on their in-class discussions and online activities. The discussion includes four design features for guiding future applet creation.

  11. Designing Forest Adaptation Experiments through Manager-Scientist Partnerships

    NASA Astrophysics Data System (ADS)

    Nagel, L. M.; Swanston, C.; Janowiak, M.

    2014-12-01

    Three common forest adaptation options discussed in the context of an uncertain future climate are: creating resistance, promoting resilience, and enabling forests to respond to change. Though there is consensus on the broad management goals addressed by each of these options, translating these concepts into management plans specific for individual forest types that vary in structure, composition, and function remains a challenge. We will describe a decision-making framework that we employed within a manager-scientist partnership to develop a suite of adaptation treatments for two contrasting forest types as part of a long-term forest management experiment. The first, in northern Minnesota, is a red pine-dominated forest with components of white pine, aspen, paper birch, and northern red oak, with a hazel understory. The second, in southwest Colorado, is a warm-dry mixed conifer forest dominated by ponderosa pine, white fir, and Douglas-fir, with scattered aspen and an understory of Gambel oak. The current conditions at both sites are characterized by overstocking with moderate-to-high fuel loading, vulnerability to numerous forest health threats, and are generally uncharacteristic of historic structure and composition. The desired future condition articulated by managers for each site included elements of historic structure and natural range of variability, but were greatly tempered by known vulnerabilities and projected changes to climate and disturbance patterns. The resultant range of treatments we developed are distinct for each forest type, and address a wide range of management objectives.

  12. Using Tests Designed to Measure Individual Sensorimotor Subsystem Perfomance to Predict Locomotor Adaptability

    NASA Technical Reports Server (NTRS)

    Peters, B. T.; Caldwell, E. E.; Batson, C. D.; Guined, J. R.; DeDios, Y. E.; Stepanyan, V.; Gadd, N. E.; Szecsy, D. L.; Mulavara, A. P.; Seidler, R. D.; Bloomberg, J. J.

    2014-01-01

    Astronauts experience sensorimotor disturbances during the initial exposure to microgravity and during the readapation phase following a return to a gravitational environment. These alterations may lead to disruption in the ability to perform mission critical functions during and after these gravitational transitions. Astronauts show significant inter-subject variation in adaptive capability following gravitational transitions. The way each individual's brain synthesizes the available visual, vestibular and somatosensory information is likely the basis for much of the variation. Identifying the presence of biases in each person's use of information available from these sensorimotor subsystems and relating it to their ability to adapt to a novel locomotor task will allow us to customize a training program designed to enhance sensorimotor adaptability. Eight tests are being used to measure sensorimotor subsystem performance. Three of these use measures of body sway to characterize balance during varying sensorimotor challenges. The effect of vision is assessed by repeating conditions with eyes open and eyes closed. Standing on foam, or on a support surface that pitches to maintain a constant ankle angle provide somatosensory challenges. Information from the vestibular system is isolated when vision is removed and the support surface is compromised, and it is challenged when the tasks are done while the head is in motion. The integration and dominance of visual information is assessed in three additional tests. The Rod & Frame Test measures the degree to which a subject's perception of the visual vertical is affected by the orientation of a tilted frame in the periphery. Locomotor visual dependence is determined by assessing how much an oscillating virtual visual world affects a treadmill-walking subject. In the third of the visual manipulation tests, subjects walk an obstacle course while wearing up-down reversing prisms. The two remaining tests include direct

  13. Cooperation, competition and the emergence of criticality in communities of adaptive systems

    NASA Astrophysics Data System (ADS)

    Hidalgo, Jorge; Grilli, Jacopo; Suweis, Samir; Maritan, Amos; Muñoz, Miguel A.

    2016-03-01

    The hypothesis that living systems can benefit from operating at the vicinity of critical points has gained momentum in recent years. Criticality may confer an optimal balance between too ordered and exceedingly noisy states. Here we present a model, based on information theory and statistical mechanics, illustrating how and why a community of agents aimed at understanding and communicating with each other converges to a globally coherent state in which all individuals are close to an internal critical state, i.e. at the borderline between order and disorder. We study—both analytically and computationally—the circumstances under which criticality is the best possible outcome of the dynamical process, confirming the convergence to critical points under very generic conditions. Finally, we analyze the effect of cooperation (agents trying to enhance not only their fitness, but also that of other individuals) and competition (agents trying to improve their own fitness and to diminish those of competitors) within our setting. The conclusion is that, while competition fosters criticality, cooperation hinders it and can lead to more ordered or more disordered consensual outcomes.

  14. Adaptation to the edge of chaos and critical scaling in self-adjusting dynamical systems

    NASA Astrophysics Data System (ADS)

    Melby, Paul Christian

    We present a mechanism for adaptation in dynamical systems. Systems which have this mechanism are called self-adjusting systems. The control parameters in a self-adjusting system are slowly varying, rather than constant. The dynamics of the control parameters are governed by a low-pass filtered feedback from the dynamical variables. We apply this model to several systems, numerically, analytically, and experimentally, and examine the behavior of the control parameters. We observe a high probability of finding the parameter at the boundary between periodicity and chaos. We therefore find that self-adjusting systems adapt to the edge of chaos. In addition, we find that noise in the system drives the parameter away from the edge of chaos on very long timescales so that chaos is suppressed in the system. We show that, with the presence of noise, the parameter can re-enter the chaotic regime. This is called a chaotic outbreak in the system and we find that the distribution of outbreaks is a power-law with the duration of the outbreak. We then study the robustness of adaptation to the edge of chaos by examining the effect of a control force being applied to the parameter. We find the behavior to be very robust, except for very large control forces. Finally, we look at systems of coupled maps and show that, adaptation to the edge of chaos occurs in systems of higher dimensions, as well.

  15. Critically Adaptive Pedagogical Relations: The Relevance for Educational Policy and Practice

    ERIC Educational Resources Information Center

    Griffiths, Morwenna

    2013-01-01

    In this article Morwenna Griffiths argues that teacher education policies should be predicated on a proper and full understanding of pedagogical relations as contingent, responsive, and adaptive over the course of a career. Griffiths uses the example of the recent report on teacher education in Scotland, by Graham Donaldson, to argue that for all…

  16. Critical Issues in Research Design in Action Research in an SME Development Context

    ERIC Educational Resources Information Center

    McGrath, Helen; O'Toole, Thomas

    2012-01-01

    Purpose: The main aim of this paper is to develop guidelines on the critical issues to consider in research design in an action research (AR) environment for SME network capability development. Design/methodology/approach: The issues in research design for AR studies are developed from the authors' experience in running learning sets but, in…

  17. Water Infrastructure Adaptation in New Urban Design: Possibilities and Constraints

    EPA Science Inventory

    Natural constraints, including climate change and dynamic socioeconomic development, can significantly impact the way we plan, design, and operate water infrastructure, thus its sustainability to deliver reliable quality water supplies and comply with environmental regulations. ...

  18. Adaptation and Evaluation of Online Self-learning Modules to Teach Critical Appraisal and Evidence-Based Practice in Nursing: An International Collaboration.

    PubMed

    Gagnon, Johanne; Gagnon, Marie-Pierre; Buteau, Rose-Anne; Azizah, Ginette Mbourou; Jetté, Sylvie; Lampron, Amélie; Simonyan, David; Asua, José; Reviriego, Eva

    2015-07-01

    Healthcare professionals need to update their knowledge and acquire skills to continually inform their practice based on scientific evidence. This study was designed to evaluate online self-learning modules on critical appraisal skills to promote the use of research in clinical practice among nurses from Quebec (Canada) and the Basque Country (Spain). The teaching material was developed in Quebec and adapted to the Basque Country as part of an international collaboration project. A prospective pre-post study was conducted with 36 nurses from Quebec and 47 from the Basque Country. Assessment comprised the administration of questionnaires before and after the course in order to explore the main intervention outcomes: knowledge acquisition and self-learning readiness. Satisfaction was also measured at the end of the course. Two of the three research hypotheses were confirmed: (1) participants significantly improved their overall knowledge score after the educational intervention; and (2) they were, in general, satisfied with the course, giving it a rating of seven out of 10. Participants also reported a greater readiness for self-directed learning after the course, but this result was not significant in Quebec. The study provides unique knowledge on the cultural adaptation of online self-learning modules for teaching nurses about critical appraisal skills and evidence-based practice.

  19. The role of cognitive appraisal in adaptation to traumatic stress in adults with serious mental illness: a critical review.

    PubMed

    Sherrer, Margaret V

    2011-07-01

    A compelling body of literature suggests that negative appraisal may be associated with adverse reactions to traumatic stress. However, very few studies have examined how appraisal influences posttraumatic adaptation in people with serious mental illness (SMI) despite evidence of disproportionately high prevalence rates of trauma exposure and Posttraumatic Stress Disorder (PTSD) in this population. The purpose of this article is to provide a critical analysis of the theoretical and empirical literature on cognitive appraisal and psychological adaptation to traumatic stress with a specific focus on individuals diagnosed with SMI. It will be argued that appraisal is a key correlate that may partially account for higher rates of PTSD in people diagnosed with major mood and schizophrenia-spectrum disorders, meriting special consideration for future research.

  20. Translation, adaptation, and validation of the behavioral pain scale and the critical-care pain observational tools in Taiwan

    PubMed Central

    Hsiung, Nai-Huan; Yang, Yen; Lee, Ming Shinn; Dalal, Koustuv; Smith, Graeme D

    2016-01-01

    This study describes the cultural adaptation and testing of the behavioral pain scale (BPS) and the critical-care pain observation tools (CPOT) for pain assessment in Taiwan. The cross-cultural adaptation followed the steps of translation, including forward translation, back-translation, evaluation of the translations by a committee of experts, adjustments, and then piloting of the prefinal versions of the BPS and the CPOT. A content validity index was used to assess content validities of the BPS and the CPOT, with 0.80 preset as the level that would be regarded as acceptable. The principal investigator then made adjustments when the content validity index was <0.80. The pilot test was performed with a sample of ten purposively selected patients by 2 medical staff from a medical care center in Taiwan. The BPS and the CPOT are adequate instruments for the assessment of pain levels in patients who cannot communicate due to sedation and ventilation treatments.

  1. Translation, adaptation, and validation of the behavioral pain scale and the critical-care pain observational tools in Taiwan

    PubMed Central

    Hsiung, Nai-Huan; Yang, Yen; Lee, Ming Shinn; Dalal, Koustuv; Smith, Graeme D

    2016-01-01

    This study describes the cultural adaptation and testing of the behavioral pain scale (BPS) and the critical-care pain observation tools (CPOT) for pain assessment in Taiwan. The cross-cultural adaptation followed the steps of translation, including forward translation, back-translation, evaluation of the translations by a committee of experts, adjustments, and then piloting of the prefinal versions of the BPS and the CPOT. A content validity index was used to assess content validities of the BPS and the CPOT, with 0.80 preset as the level that would be regarded as acceptable. The principal investigator then made adjustments when the content validity index was <0.80. The pilot test was performed with a sample of ten purposively selected patients by 2 medical staff from a medical care center in Taiwan. The BPS and the CPOT are adequate instruments for the assessment of pain levels in patients who cannot communicate due to sedation and ventilation treatments. PMID:27695360

  2. Electron-proton spectrometer: Summary for critical design review

    NASA Technical Reports Server (NTRS)

    1972-01-01

    The electron-proton spectrometer (EPS) is mounted external to the Skylab module complex on the command service module. It is designed to make a 2 pi omni-directional measurement of electrons and protons which result from solar flares or enhancement of the radiation belts. The EPS data will provide accurate radiation dose information so that uncertain Relative biological effectiveness factors are eliminated by measuring the external particle spectra. Astronaut radiation safety, therefore, can be ensured, as the EPS data can be used to correct or qualify radiation dose measurements recorded by other radiation measuring instrumentation within the Skylab module complex. The EPS has the capability of measuring and extremely wide dynamic radiation dose rate range, approaching 10 to the 7th power. Simultaneously the EPS has the capability to process data from extremely high radiation fields such as might be encountered in the wake of an intense solar flare.

  3. 77 FR 48367 - Endangered and Threatened Wildlife and Plants; Designation of Critical Habitat for Ipomopsis...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-13

    ... is considered to be critical habitat. We listed these three plant species on July 27, 2011 (76 FR 45054). At the same time, we proposed to designate critical habitat (76 FR 45078). Section 4(b)(2) of... final listing rule published in the Federal Register on July 27, 2011 (76 FR 45054). For information...

  4. 76 FR 29107 - Endangered and Threatened Wildlife and Plants; Final Revised Designation of Critical Habitat for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-19

    ... October 6, 1998 (63 FR 53596), the previous proposed critical habitat that published in the Federal Register on April 6, 2004 (69 FR 18018), and the proposed revised designation of critical habitat that published in the Federal Register on April 1, 2010 (75 FR 16404). Information on the associated...

  5. 76 FR 64995 - Endangered and Threatened Wildlife and Plants; Designation of Revised Critical Habitat for the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-19

    ... designation (73 FR 5920; January 31, 2008). A summary of topics that are relevant to this proposed critical... FR 5494); the first and second rules proposing critical habitat published in the Federal Register on August 3, 1999 (64 FR 42250) and November 28, 2006 (71 FR 68914), respectively; and the subsequent...

  6. 75 FR 59899 - Endangered and Threatened Wildlife and Plants: Proposed Rulemaking To Designate Critical Habitat...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-28

    ... the ESA (74 FR 1937). Under the ESA, we are responsible for designating critical habitat for all... al., 2009), and the proposed and final listing rules for black abalone (71 FR 1986, January 11, 2008; 74 FR 1937, January 14, 2009). Methods and Criteria Used To Identify Critical Habitat In...

  7. 77 FR 43222 - Endangered and Threatened Wildlife and Plants; Designation of Critical Habitat for the Tidewater...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-24

    ... designation of critical habitat published in the Federal Register on October 19, 2011 (76 FR 64996). For more... Register on February 4, 1994 (59 FR 5494); the first and second rules proposing critical habitat published... published October 19, 2011 (76 FR 64996) is reopened. We will consider comments received on or before...

  8. 77 FR 2254 - Endangered and Threatened Wildlife and Plants; Designation of Critical Habitat for Mississippi...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-17

    ... rule (76 FR 59774) to designate critical habitat for the Mississippi gopher frog, and announced the... delineating Mississippi gopher frog critical habitat in our revised proposed rule (76 FR 59774), we used the... our September 27, 2011, revised proposed rule (76 FR 59774). Given the limited amount of...

  9. 75 FR 319 - Endangered and Threatened Species: Proposed Rule To Revise the Critical Habitat Designation for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-05

    ... The leatherback sea turtle was listed as endangered throughout its range on June 2, 1970 (35 FR 8491... designated critical habitat for leatherbacks on September 26, 1978 (43 FR 43688). The critical habitat area... meters) curve shoreward to the level of mean high tide (44 FR 17710). On October 2, 2007, we received...

  10. Task 8 -- Design and test of critical components

    SciTech Connect

    Chance, T.F.

    1996-11-01

    This report covers tasks 8.1, 8.1.1, and 8.2. The primary objective of Task 8.1, Particulates Flow Deposition, is to characterize the particulate generated in an operating gas turbine combined cycle (GTCC) power plant whose configuration approximates that proposed for an ATS power plant. In addition, the task is to evaluate the use of full-flow filtering to reduce the steam particulate loads. Before the start of this task, GE had already negotiated an agreement with the candidate power plant, piping and a filter unit had already been installed at the power plant site, and major elements of the data acquisition system had been purchased. The objective of Task 8.1.1, Coolant Purity, is to expose typical ATS gas turbine airfoil cooling channel geometries to real steam flow to determine whether there are any unexpected deposit formations. The task is a static analog of the centrifugal deposition rig trials of Task 8.2, in which a bucket channel return bend is exposed to steam flow. Two cooling channel geometries are of primary interest in this static exposure. The primary objective of Task 8.2, Particle Centrifugal Sedimentation, is to determine the settling characteristics of particles in a cooling stream from an operating gas turbine combined cycle (GTCC) power plant when that stream is ducted through a passage experiencing the G-loads expected in a simulated bucket channel specimen representative of designs proposed for an ATS gas turbine.

  11. Using Critical Incidents of Instructional Design and Multimedia Production Activities to Investigate Instructional Designers' Current Practices and Roles

    ERIC Educational Resources Information Center

    Sugar, William A.; Luterbach, Kenneth J.

    2016-01-01

    Through consideration of critical incidents, this study analyzed 106 effective, ineffective and extraordinary instructional design and multimedia production (MP) activities discussed by 36 instructional design professionals. This evaluation provided insights into these professionals' best and not so best practices during the past 6 months.…

  12. A Testlet Assembly Design for Adaptive Multistage Tests

    ERIC Educational Resources Information Center

    Luecht, Richard; Brumfield, Terry; Breithaupt, Krista

    2006-01-01

    This article describes multistage tests and some practical test development considerations related to the design and implementation of a multistage test, using the Uniform CPA (certified public accountant) Examination as a case study. The article further discusses the use of automated test assembly procedures in an operational context to produce…

  13. Context-Aware Design for Process Flexibility and Adaptation

    ERIC Educational Resources Information Center

    Yao, Wen

    2012-01-01

    Today's organizations face continuous and unprecedented changes in their business environment. Traditional process design tools tend to be inflexible and can only support rigidly defined processes (e.g., order processing in the supply chain). This considerably restricts their real-world applications value, especially in the dynamic and…

  14. Adapting Wood Technology to Teach Design and Engineering

    ERIC Educational Resources Information Center

    Rummel, Robert A.

    2012-01-01

    Technology education has changed dramatically over the last few years. The transition of industrial arts to technology education and more recently the pursuit of design and engineering has resulted in technology education teachers often needing to change their curriculum and course activities to meet the demands of a rapidly changing profession.…

  15. Optimal adaptive two-stage designs for early phase II clinical trials.

    PubMed

    Shan, Guogen; Wilding, Gregory E; Hutson, Alan D; Gerstenberger, Shawn

    2016-04-15

    Simon's optimal two-stage design has been widely used in early phase clinical trials for Oncology and AIDS studies with binary endpoints. With this approach, the second-stage sample size is fixed when the trial passes the first stage with sufficient activity. Adaptive designs, such as those due to Banerjee and Tsiatis (2006) and Englert and Kieser (2013), are flexible in the sense that the second-stage sample size depends on the response from the first stage, and these designs are often seen to reduce the expected sample size under the null hypothesis as compared with Simon's approach. An unappealing trait of the existing designs is that they are not associated with a second-stage sample size, which is a non-increasing function of the first-stage response rate. In this paper, an efficient intelligent process, the branch-and-bound algorithm, is used in extensively searching for the optimal adaptive design with the smallest expected sample size under the null, while the type I and II error rates are maintained and the aforementioned monotonicity characteristic is respected. The proposed optimal design is observed to have smaller expected sample sizes compared to Simon's optimal design, and the maximum total sample size of the proposed adaptive design is very close to that from Simon's method. The proposed optimal adaptive two-stage design is recommended for use in practice to improve the flexibility and efficiency of early phase therapeutic development. PMID:26526165

  16. Adapting, Not Adopting: Barriers Affecting Teaching for Critical Thinking at Two Rwandan Universities

    ERIC Educational Resources Information Center

    Schendel, Rebecca

    2016-01-01

    A recent study of student learning at three of Rwanda's most prestigious public universities has suggested that Rwandan students are not improving in their critical thinking ability during their time at university. This article reports on a series of faculty-level case studies, which were conducted at two of the participating institutions in order…

  17. A modified varying-stage adaptive phase II/III clinical trial design.

    PubMed

    Dong, Gaohong; Vandemeulebroecke, Marc

    2016-07-01

    Conventionally, adaptive phase II/III clinical trials are carried out with a strict two-stage design. Recently, a varying-stage adaptive phase II/III clinical trial design has been developed. In this design, following the first stage, an intermediate stage can be adaptively added to obtain more data, so that a more informative decision can be made. Therefore, the number of further investigational stages is determined based upon data accumulated to the interim analysis. This design considers two plausible study endpoints, with one of them initially designated as the primary endpoint. Based on interim results, another endpoint can be switched as the primary endpoint. However, in many therapeutic areas, the primary study endpoint is well established. Therefore, we modify this design to consider one study endpoint only so that it may be more readily applicable in real clinical trial designs. Our simulations show that, the same as the original design, this modified design controls the Type I error rate, and the design parameters such as the threshold probability for the two-stage setting and the alpha allocation ratio in the two-stage setting versus the three-stage setting have a great impact on the design characteristics. However, this modified design requires a larger sample size for the initial stage, and the probability of futility becomes much higher when the threshold probability for the two-stage setting gets smaller. Copyright © 2016 John Wiley & Sons, Ltd.

  18. Parametric study of critical constraints for a canard configured medium range transport using conceptual design optimization

    NASA Technical Reports Server (NTRS)

    Arbuckle, P. D.; Sliwa, S. M.

    1983-01-01

    Constrained parameter optimization was used to perform optimal conceptual design of both canard and conventional configurations of a medium range transport. A number of design constants and design constraints were systematically varied to compare the sensitivities of canard and conventional configurations to a variety of technology assumptions. Main landing gear location and horizontal stabilizer high-lift performance were identified as critical design parameters for a statically stable, subsonic canard transport.

  19. On Adaptive Extended Compatibility Changing Type of Product Design Strategy

    NASA Astrophysics Data System (ADS)

    Wenwen, Jiang; Zhibin, Xie

    The article uses research ways of Enterprise localization and enterprise's development course to research strategy of company's product design and development. It announces at different stages for development, different kinds of enterprises will adopt product design and development policies of different modes. It also announces close causality between development course of company and central technology and product. The result indicated enterprises in leading position in market, technology and brand adopt pioneer strategy type of product research and development. These enterprise relying on the large-scale leading enterprise offering a complete set service adopts the passively duplicating type tactic of product research and development. Some enterprise in part of advantage in technology, market, management or brand adopt following up strategy of product research and development. The enterprises with relative advantage position adopt the strategy of technology applied taking optimizing services as centre in product research and development in fields of brand culture and market service.

  20. Design of the Subaru laser guide star adaptive optics module

    NASA Astrophysics Data System (ADS)

    Watanabe, Makoto; Takami, Hideki; Takato, Naruhisa; Colley, Stephen; Eldred, Michael; Kane, Thomas; Guyon, Olivier; Hattori, Masayuki; Goto, Miwa; Iye, Masanori; Hayano, Yutaka; Kamata, Yukiko; Arimoto, Nobuo; Kobayashi, Naoto; Minowa, Yosuke

    2004-10-01

    The laser guide star adaptive optics (AO) module for the Subaru Telescope will be installed at the f/13.9 IR Nasmyth focus, and provides the compensated image for the science instrument without change of the focal ratio. The optical components are mounted on an optical bench, and the flexure depending on the telescope pointing is eliminated. The transferred field of view for the science instrument is 2 arcmin diameter, but a 2.7 arcmin diameter field is available for tip-tilt sensing. The science path of the AO module contains five mirrors, including a pair of off-axis parabolic mirrors and a deformable mirror. It has also three additional mirrors for an image rotator. The AO module has a visible 188-element curvature based wavefront sensor (WFS) with photon-counting avalanche photodiode (APD) modules. It measures high-order terms of wavefront using either of a single laser (LGS) or natural guide star (NGS) within a 2 arcmin diameter field. The AO module has also a visible 2 x 2 sub-aperture Shack-Hartmann WFS with 16 APD modules. It measures tip-tilt and slow defocus terms of wavefront by using a single NGS within a 2.7 arcmin diameter field when a LGS is used for high-order wavefront sensing. The module has also an infrared 2 x 2 sub-aperture Shack-Hartmann WFS with a HgCdTe array as an option. Both high- and low-order visible WFSs have their own guide star acquisition units with two steering fold mirrors. The AO module has also a source simulator. It simulates LGS and NGS beams, simultaneously, with and without atmospheric turbulence by two turbulent layer at about 0 and 6 km altitudes, and reproduces the isoplanatism and the cone effect for the LGS beam.

  1. Teaching as Designing: Preparing Pre-Service Teachers for Adaptive Teaching

    ERIC Educational Resources Information Center

    Jordan, Michelle E.

    2016-01-01

    This conceptual article explores teaching as design work, arguing that a critical thing teachers do is design systems that enable their students to learn. Designing occurs when teachers generate new learning activities or modify curricular programs to create coherence for themselves and their students. Nonetheless, few teacher education programs…

  2. A new approach for designing self-organizing systems and application to adaptive control

    NASA Technical Reports Server (NTRS)

    Ramamoorthy, P. A.; Zhang, Shi; Lin, Yueqing; Huang, Song

    1993-01-01

    There is tremendous interest in the design of intelligent machines capable of autonomous learning and skillful performance under complex environments. A major task in designing such systems is to make the system plastic and adaptive when presented with new and useful information and stable in response to irrelevant events. A great body of knowledge, based on neuro-physiological concepts, has evolved as a possible solution to this problem. Adaptive resonance theory (ART) is a classical example under this category. The system dynamics of an ART network is described by a set of differential equations with nonlinear functions. An approach for designing self-organizing networks characterized by nonlinear differential equations is proposed.

  3. Group-Work in the Design of Complex Adaptive Learning Strategies

    ERIC Educational Resources Information Center

    Mavroudi, Anna; Hadzilacos, Thanasis

    2013-01-01

    This paper presents a case study where twelve graduate students undertook the demanding role of the adaptive e-course developer and worked collaboratively on an authentic and complex design task in the context of open and distance tertiary education. The students had to work in groups in order to conceptualise and design a learning scenario for…

  4. Impact of New Designs for the Comprehensive High School: Evidence from Two Early Adapters.

    ERIC Educational Resources Information Center

    Copa, George H.

    The New Designs for the Comprehensive High School (NDCHS) project was conducted to develop design processes and specifications for developing new comprehensive high schools, and for restructuring existing schools in accordance with the comprehensive high school model. The project's impact on student learning at two early adapters of the…

  5. A Framework for Adaptive Learning Design in a Web-Conferencing Environment

    ERIC Educational Resources Information Center

    Bower, Matt

    2016-01-01

    Many recent technologies provide the ability to dynamically adjust the interface depending on the emerging cognitive and collaborative needs of the learning episode. This means that educators can adaptively re-design the learning environment during the lesson, rather than purely relying on preemptive learning design thinking. Based on a…

  6. Systematic design and analysis of laser-guide-star adaptive-optics systems for large telescopes

    SciTech Connect

    Gavel, D.T.; Morris, J.R.; Vernon, R.G.

    1994-02-01

    The authors discuss the design of laser-guided adaptive-optics systems for the large, 8-10-m-class telescopes. Through proper choice of system components and optimized system design, the laser power that is needed at the astronomical site can be kept to a minimum. 37 refs., 9 figs., 3 tabs.

  7. Key techniques and applications of adaptive growth method for stiffener layout design of plates and shells

    NASA Astrophysics Data System (ADS)

    Ding, Xiaohong; Ji, Xuerong; Ma, Man; Hou, Jianyun

    2013-11-01

    The application of the adaptive growth method is limited because several key techniques during the design process need manual intervention of designers. Key techniques of the method including the ground structure construction and seed selection are studied, so as to make it possible to improve the effectiveness and applicability of the adaptive growth method in stiffener layout design optimization of plates and shells. Three schemes of ground structures, which are comprised by different shell elements and beam elements, are proposed. It is found that the main stiffener layouts resulted from different ground structures are almost the same, but the ground structure comprised by 8-nodes shell elements and both 3-nodes and 2-nodes beam elements can result in clearest stiffener layout, and has good adaptability and low computational cost. An automatic seed selection approach is proposed, which is based on such selection rules that the seeds should be positioned on where the structural strain energy is great for the minimum compliance problem, and satisfy the dispersancy requirement. The adaptive growth method with the suggested key techniques is integrated into an ANSYS-based program, which provides a design tool for the stiffener layout design optimization of plates and shells. Typical design examples, including plate and shell structures to achieve minimum compliance and maximum bulking stability are illustrated. In addition, as a practical mechanical structural design example, the stiffener layout of an inlet structure for a large-scale electrostatic precipitator is also demonstrated. The design results show that the adaptive growth method integrated with the suggested key techniques can effectively and flexibly deal with stiffener layout design problem for plates and shells with complex geometrical shape and loading conditions to achieve various design objectives, thus it provides a new solution method for engineering structural topology design optimization.

  8. Simple adaptive control system design for a quadrotor with an internal PFC

    NASA Astrophysics Data System (ADS)

    Mizumoto, Ikuro; Nakamura, Takuto; Kumon, Makoto; Takagi, Taro

    2014-12-01

    The paper deals with an adaptive control system design problem for a four rotor helicopter or quadrotor. A simple adaptive control design scheme with a parallel feedforward compensator (PFC) in the internal loop of the considered quadrotor will be proposed based on the backstepping strategy. As is well known, the backstepping control strategy is one of the advanced control strategy for nonlinear systems. However, the control algorithm will become complex if the system has higher order relative degrees. We will show that one can skip some design steps of the backstepping method by introducing a PFC in the inner loop of the considered quadrotor, so that the structure of the obtained controller will be simplified and a high gain based adaptive feedback control system will be designed. The effectiveness of the proposed method will be confirmed through numerical simulations.

  9. Simple adaptive control system design for a quadrotor with an internal PFC

    SciTech Connect

    Mizumoto, Ikuro; Nakamura, Takuto; Kumon, Makoto; Takagi, Taro

    2014-12-10

    The paper deals with an adaptive control system design problem for a four rotor helicopter or quadrotor. A simple adaptive control design scheme with a parallel feedforward compensator (PFC) in the internal loop of the considered quadrotor will be proposed based on the backstepping strategy. As is well known, the backstepping control strategy is one of the advanced control strategy for nonlinear systems. However, the control algorithm will become complex if the system has higher order relative degrees. We will show that one can skip some design steps of the backstepping method by introducing a PFC in the inner loop of the considered quadrotor, so that the structure of the obtained controller will be simplified and a high gain based adaptive feedback control system will be designed. The effectiveness of the proposed method will be confirmed through numerical simulations.

  10. The Study and Design of Adaptive Learning System Based on Fuzzy Set Theory

    NASA Astrophysics Data System (ADS)

    Jia, Bing; Zhong, Shaochun; Zheng, Tianyang; Liu, Zhiyong

    Adaptive learning is an effective way to improve the learning outcomes, that is, the selection of learning content and presentation should be adapted to each learner's learning context, learning levels and learning ability. Adaptive Learning System (ALS) can provide effective support for adaptive learning. This paper proposes a new ALS based on fuzzy set theory. It can effectively estimate the learner's knowledge level by test according to learner's target. Then take the factors of learner's cognitive ability and preference into consideration to achieve self-organization and push plan of knowledge. This paper focuses on the design and implementation of domain model and user model in ALS. Experiments confirmed that the system providing adaptive content can effectively help learners to memory the content and improve their comprehension.

  11. A single network adaptive critic (SNAC) architecture for optimal control synthesis for a class of nonlinear systems.

    PubMed

    Padhi, Radhakant; Unnikrishnan, Nishant; Wang, Xiaohua; Balakrishnan, S N

    2006-12-01

    Even though dynamic programming offers an optimal control solution in a state feedback form, the method is overwhelmed by computational and storage requirements. Approximate dynamic programming implemented with an Adaptive Critic (AC) neural network structure has evolved as a powerful alternative technique that obviates the need for excessive computations and storage requirements in solving optimal control problems. In this paper, an improvement to the AC architecture, called the "Single Network Adaptive Critic (SNAC)" is presented. This approach is applicable to a wide class of nonlinear systems where the optimal control (stationary) equation can be explicitly expressed in terms of the state and costate variables. The selection of this terminology is guided by the fact that it eliminates the use of one neural network (namely the action network) that is part of a typical dual network AC setup. As a consequence, the SNAC architecture offers three potential advantages: a simpler architecture, lesser computational load and elimination of the approximation error associated with the eliminated network. In order to demonstrate these benefits and the control synthesis technique using SNAC, two problems have been solved with the AC and SNAC approaches and their computational performances are compared. One of these problems is a real-life Micro-Electro-Mechanical-system (MEMS) problem, which demonstrates that the SNAC technique is applicable to complex engineering systems.

  12. Adaptive fuzzy switched control design for uncertain nonholonomic systems with input nonsmooth constraint

    NASA Astrophysics Data System (ADS)

    Li, Yongming; Tong, Shaocheng

    2016-10-01

    In this paper, a fuzzy adaptive switched control approach is proposed for a class of uncertain nonholonomic chained systems with input nonsmooth constraint. In the control design, an auxiliary dynamic system is designed to address the input nonsmooth constraint, and an adaptive switched control strategy is constructed to overcome the uncontrollability problem associated with x0(t0) = 0. By using fuzzy logic systems to tackle unknown nonlinear functions, a fuzzy adaptive control approach is explored based on the adaptive backstepping technique. By constructing the combination approximation technique and using Young's inequality scaling technique, the number of the online learning parameters is reduced to n and the 'explosion of complexity' problem is avoid. It is proved that the proposed method can guarantee that all variables of the closed-loop system converge to a small neighbourhood of zero. Two simulation examples are provided to illustrate the effectiveness of the proposed control approach.

  13. Evaluation of single and two-stage adaptive sampling designs for estimation of density and abundance of freshwater mussels in a large river

    USGS Publications Warehouse

    Smith, D.R.; Rogala, J.T.; Gray, B.R.; Zigler, S.J.; Newton, T.J.

    2011-01-01

    Reliable estimates of abundance are needed to assess consequences of proposed habitat restoration and enhancement projects on freshwater mussels in the Upper Mississippi River (UMR). Although there is general guidance on sampling techniques for population assessment of freshwater mussels, the actual performance of sampling designs can depend critically on the population density and spatial distribution at the project site. To evaluate various sampling designs, we simulated sampling of populations, which varied in density and degree of spatial clustering. Because of logistics and costs of large river sampling and spatial clustering of freshwater mussels, we focused on adaptive and non-adaptive versions of single and two-stage sampling. The candidate designs performed similarly in terms of precision (CV) and probability of species detection for fixed sample size. Both CV and species detection were determined largely by density, spatial distribution and sample size. However, designs did differ in the rate that occupied quadrats were encountered. Occupied units had a higher probability of selection using adaptive designs than conventional designs. We used two measures of cost: sample size (i.e. number of quadrats) and distance travelled between the quadrats. Adaptive and two-stage designs tended to reduce distance between sampling units, and thus performed better when distance travelled was considered. Based on the comparisons, we provide general recommendations on the sampling designs for the freshwater mussels in the UMR, and presumably other large rivers.

  14. Design and Preliminary Testing of the International Docking Adapter's Peripheral Docking Target

    NASA Technical Reports Server (NTRS)

    Foster, Christopher W.; Blaschak, Johnathan; Eldridge, Erin A.; Brazzel, Jack P.; Spehar, Peter T.

    2015-01-01

    The International Docking Adapter's Peripheral Docking Target (PDT) was designed to allow a docking spacecraft to judge its alignment relative to the docking system. The PDT was designed to be compatible with relative sensors using visible cameras, thermal imagers, or Light Detection and Ranging (LIDAR) technologies. The conceptual design team tested prototype designs and materials to determine the contrast requirements for the features. This paper will discuss the design of the PDT, the methodology and results of the tests, and the conclusions pertaining to PDT design that were drawn from testing.

  15. The congruency sequence effect 3.0: a critical test of conflict adaptation.

    PubMed

    Duthoo, Wout; Abrahamse, Elger L; Braem, Senne; Boehler, C Nico; Notebaert, Wim

    2014-01-01

    Over the last two decades, the congruency sequence effect (CSE) -the finding of a reduced congruency effect following incongruent trials in conflict tasks- has played a central role in advancing research on cognitive control. According to the influential conflict-monitoring account, the CSE reflects adjustments in selective attention that enhance task focus when needed, often termed conflict adaptation. However, this dominant interpretation of the CSE has been called into question by several alternative accounts that stress the role of episodic memory processes: feature binding and (stimulus-response) contingency learning. To evaluate the notion of conflict adaptation in accounting for the CSE, we construed versions of three widely used experimental paradigms (the colour-word Stroop, picture-word Stroop and flanker task) that effectively control for feature binding and contingency learning. Results revealed that a CSE can emerge in all three tasks. This strongly suggests a contribution of attentional control to the CSE and highlights the potential of these unprecedentedly clean paradigms for further examining cognitive control.

  16. Multivariable output feedback robust adaptive tracking control design for a class of delayed systems

    NASA Astrophysics Data System (ADS)

    Mirkin, Boris; Gutman, Per-Olof

    2015-02-01

    In this paper, we develop a model reference adaptive control scheme for a class of multi-input multi-output nonlinearly perturbed dynamic systems with unknown time-varying state delays which is also robust with respect to an external disturbance with unknown bounds. The output feedback adaptive control scheme uses feedback actions only, and thus does not require a direct measurement of the command or disturbance signals. A suitable Lyapunov-Krasovskii type functional is introduced to design the adaptation algorithms and to prove stability.

  17. Low Level Waste Conceptual Design Adaption to Poor Geological Conditions

    SciTech Connect

    Bell, J.; Drimmer, D.; Giovannini, A.; Manfroy, P.; Maquet, F.; Schittekat, J.; Van Cotthem, A.; Van Echelpoel, E.

    2002-02-26

    Since the early eighties, several studies have been carried out in Belgium with respect to a repository for the final disposal of low-level radioactive waste (LLW). In 1998, the Belgian Government decided to restrict future investigations to the four existing nuclear sites in Belgium or sites that might show interest. So far, only two existing nuclear sites have been thoroughly investigated from a geological and hydrogeological point of view. These sites are located in the North-East (Mol-Dessel) and in the mid part (Fleurus-Farciennes) of the country. Both sites have the disadvantage of presenting poor geological and hydrogeological conditions, which are rather unfavorable to accommodate a surface disposal facility for LLW. The underground of the Mol-Dessel site consists of neogene sand layers of about 180 m thick which cover a 100 meters thick clay layer. These neogene sands contain, at 20 m depth, a thin clayey layer. The groundwater level is quite close to the surface (0-2m) and finally, the topography is almost totally flat. The upper layer of the Fleurus-Farciennes site consists of 10 m silt with poor geomechanical characteristics, overlying sands (only a few meters thick) and Westphalian shales between 15 and 20 m depth. The Westphalian shales are tectonized and strongly weathered. In the past, coal seams were mined out. This activity induced locally important surface subsidence. For both nuclear sites that were investigated, a conceptual design was made that could allow any unfavorable geological or hydrogeological conditions of the site to be overcome. In Fleurus-Farciennes, for instance, the proposed conceptual design of the repository is quite original. It is composed of a shallow, buried concrete cylinder, surrounded by an accessible concrete ring, which allows permanent inspection and control during the whole lifetime of the repository. Stability and drainage systems should be independent of potential differential settlements an d subsidences

  18. Brazed Joints Design and Allowables: Discuss Margins of Safety in Critical Brazed Structures

    NASA Technical Reports Server (NTRS)

    FLom, Yury

    2009-01-01

    This slide presentation tutorial discusses margins of safety in critical brazed structures. It reviews: (1) the present situation (2) definition of strength (3) margins of safety (4) design allowables (5) mechanical testing (6) failure criteria (7) design flowchart (8) braze gap (9) residual stresses and (10) delayed failures. This presentation addresses the strength of the brazed joints, the methods of mechanical testing, and our ability to evaluate the margins of safety of the brazed joints as it applies to the design of critical and expensive brazed assemblies.

  19. Exploring Gigabyte Datasets in Real Time: Architectures, Interfaces and Time-Critical Design

    NASA Technical Reports Server (NTRS)

    Bryson, Steve; Gerald-Yamasaki, Michael (Technical Monitor)

    1998-01-01

    Architectures and Interfaces: The implications of real-time interaction on software architecture design: decoupling of interaction/graphics and computation into asynchronous processes. The performance requirements of graphics and computation for interaction. Time management in such an architecture. Examples of how visualization algorithms must be modified for high performance. Brief survey of interaction techniques and design, including direct manipulation and manipulation via widgets. talk discusses how human factors considerations drove the design and implementation of the virtual wind tunnel. Time-Critical Design: A survey of time-critical techniques for both computation and rendering. Emphasis on the assignment of a time budget to both the overall visualization environment and to each individual visualization technique in the environment. The estimation of the benefit and cost of an individual technique. Examples of the modification of visualization algorithms to allow time-critical control.

  20. Adaptation of NASA technology for the optimum design of orthopedic knee implants.

    PubMed

    Saravanos, D A; Mraz, P J; Davy, D T; Hopkins, D A

    1991-03-01

    NASA technology originally developed for designing aircraft turbine-engine blades has been adapted and applied to orthopedic knee implants. This article describes a method for tailoring an implant for optimal interaction with the environment of the tibia. The implant components are designed to control stresses in the bone for minimizing bone degradation and preventing failures. Engineers expect the tailoring system to improve knee prosthesis design and allow customized implants for individual patients. PMID:10150099

  1. Design of adaptive steganographic schemes for digital images

    NASA Astrophysics Data System (ADS)

    Filler, Tomás; Fridrich, Jessica

    2011-02-01

    Most steganographic schemes for real digital media embed messages by minimizing a suitably defined distortion function. In practice, this is often realized by syndrome codes which offer near-optimal rate-distortion performance. However, the distortion functions are designed heuristically and the resulting steganographic algorithms are thus suboptimal. In this paper, we present a practical framework for optimizing the parameters of additive distortion functions to minimize statistical detectability. We apply the framework to digital images in both spatial and DCT domain by first defining a rich parametric model which assigns a cost of making a change at every cover element based on its neighborhood. Then, we present a practical method for optimizing the parameters with respect to a chosen detection metric and feature space. We show that the size of the margin between support vectors in soft-margin SVMs leads to a fast detection metric and that methods minimizing the margin tend to be more secure w.r.t. blind steganalysis. The parameters obtained by the Nelder-Mead simplex-reflection algorithm for spatial and DCT-domain images are presented and the new embedding methods are tested by blind steganalyzers utilizing various feature sets. Experimental results show that as few as 80 images are sufficient for obtaining good candidates for parameters of the cost model, which allows us to speed up the parameter search.

  2. Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion.

    PubMed

    Zhang, Ji; Fan, Jing; Venneti, Sriram; Cross, Justin R; Takagi, Toshimitsu; Bhinder, Bhavneet; Djaballah, Hakim; Kanai, Masayuki; Cheng, Emily H; Judkins, Alexander R; Pawel, Bruce; Baggs, Julie; Cherry, Sara; Rabinowitz, Joshua D; Thompson, Craig B

    2014-10-23

    Many cancer cells consume large quantities of glutamine to maintain TCA cycle anaplerosis and support cell survival. It was therefore surprising when RNAi screening revealed that suppression of citrate synthase (CS), the first TCA cycle enzyme, prevented glutamine-withdrawal-induced apoptosis. CS suppression reduced TCA cycle activity and diverted oxaloacetate, the substrate of CS, into production of the nonessential amino acids aspartate and asparagine. We found that asparagine was necessary and sufficient to suppress glutamine-withdrawal-induced apoptosis without restoring the levels of other nonessential amino acids or TCA cycle intermediates. In complete medium, tumor cells exhibiting high rates of glutamine consumption underwent rapid apoptosis when glutamine-dependent asparagine synthesis was suppressed, and expression of asparagine synthetase was statistically correlated with poor prognosis in human tumors. Coupled with the success of L-asparaginase as a therapy for childhood leukemia, the data suggest that intracellular asparagine is a critical suppressor of apoptosis in many human tumors.

  3. Critical Needs for Robust and Reliable Database for Design and Manufacturing of Ceramic Matrix Composites

    NASA Technical Reports Server (NTRS)

    Singh, M.

    1999-01-01

    Ceramic matrix composite (CMC) components are being designed, fabricated, and tested for a number of high temperature, high performance applications in aerospace and ground based systems. The critical need for and the role of reliable and robust databases for the design and manufacturing of ceramic matrix composites are presented. A number of issues related to engineering design, manufacturing technologies, joining, and attachment technologies, are also discussed. Examples of various ongoing activities in the area of composite databases. designing to codes and standards, and design for manufacturing are given.

  4. Multiobjective control design including performance robustness for gust alleviation of a wing with adaptive material actuators

    NASA Astrophysics Data System (ADS)

    Layton, Jeffrey B.

    1997-06-01

    The goal of this paper is to examine the use of covariance control to directly design reduced-order multi-objective controllers for gust alleviation using adaptive materials as the control effector. It will use piezoelectric actuators as control effectors in a finite element model of a full-size wing model. More precisely, the finite element model is of the F-16 Agile Falcon/Active Flexible Wing that is modified to use piezoelectric actuators as control effectors. The paper will also examine the interacting roles of important control design constraints and objectives for designing an aeroservoelastic system. The paper will also present some results of multiobjective control design for the model, illustrating the benefits and complexity of modern practical control design for aeroservoelastic systems that use adaptive materials for actuation.

  5. Identifying and Addressing Stakeholder Interests in Design Science Research: An Analysis Using Critical Systems Heuristics

    NASA Astrophysics Data System (ADS)

    Venable, John R.

    This paper utilises the Critical Systems Heuristics (CSH) framework developed by Werner Ulrich to critically consider the stakeholders and design goals that should be considered as relevant by researchers conducing Design Science Research (DSR). CSH provides a philosophically and theoretically grounded framework and means for critical consideration of the choices of stakeholders considered to be relevant to any system under design consideration. The paper recommends that legitimately undertaken DSR should include witnesses to represent the interests of the future consumers of the outcomes of DSR, i.e., the future clients, decision makers, professionals, and other non-included stakeholders in the future use of the solution technologies to be invented in DSR. The paper further discusses options for how witnesses might be included, who should be witnessed for and obstacles to implementing the recommendations.

  6. Design of a Model Reference Adaptive Controller for an Unmanned Air Vehicle

    NASA Technical Reports Server (NTRS)

    Crespo, Luis G.; Matsutani, Megumi; Annaswamy, Anuradha M.

    2010-01-01

    This paper presents the "Adaptive Control Technology for Safe Flight (ACTS)" architecture, which consists of a non-adaptive controller that provides satisfactory performance under nominal flying conditions, and an adaptive controller that provides robustness under off nominal ones. The design and implementation procedures of both controllers are presented. The aim of these procedures, which encompass both theoretical and practical considerations, is to develop a controller suitable for flight. The ACTS architecture is applied to the Generic Transport Model developed by NASA-Langley Research Center. The GTM is a dynamically scaled test model of a transport aircraft for which a flight-test article and a high-fidelity simulation are available. The nominal controller at the core of the ACTS architecture has a multivariable LQR-PI structure while the adaptive one has a direct, model reference structure. The main control surfaces as well as the throttles are used as control inputs. The inclusion of the latter alleviates the pilot s workload by eliminating the need for cancelling the pitch coupling generated by changes in thrust. Furthermore, the independent usage of the throttles by the adaptive controller enables their use for attitude control. Advantages and potential drawbacks of adaptation are demonstrated by performing high fidelity simulations of a flight-validated controller and of its adaptive augmentation.

  7. Adaptive Tracker Design with Identifier for Pendulum System by Conditional LMI Method and IROA

    NASA Astrophysics Data System (ADS)

    Hwang, Jiing-Dong; Tsai, Zhi-Ren

    This paper proposes a robust adaptive fuzzy PID control scheme augmented with a supervisory controller for unknown systems. In this scheme, a generalized fuzzy model is used to describe a class of unknown systems. The control strategy allows each part of the control law, i.e., a supervisory controller, a compensator, and an adaptive fuzzy PID controller, to be designed incrementally according to different guidelines. The supervisory controller in the outer loop aims at enhancing system robustness in the face of extra disturbances, variation in system parameters, and parameter drift in the adaptation law. Furthermore, an H∞ control design method using the fuzzy Lyapunov function is presented for the design of the initial control gains that guarantees transient performance at the start of closed-loop control, which is generally overlooked in many adaptive control systems. This design of the initial control gains is a compound search strategy called conditional linear matrix inequality (CLMI) approach with IROA (Improved random optimal algorithm), it leads to less complex designs than a standard LMI method by fuzzy Lyapunov function. Numerical studies of the tracking control of an uncertain inverted pendulum system demonstrate the effectiveness of the control strategy. From results of this simulation, the generalized fuzzy model reduces the rule number of T-S fuzzy model indeed.

  8. Intelligent robot control using an adaptive critic with a task control center and dynamic database

    NASA Astrophysics Data System (ADS)

    Hall, E. L.; Ghaffari, M.; Liao, X.; Alhaj Ali, S. M.

    2006-10-01

    The purpose of this paper is to describe the design, development and simulation of a real time controller for an intelligent, vision guided robot. The use of a creative controller that can select its own tasks is demonstrated. This creative controller uses a task control center and dynamic database. The dynamic database stores both global environmental information and local information including the kinematic and dynamic models of the intelligent robot. The kinematic model is very useful for position control and simulations. However, models of the dynamics of the manipulators are needed for tracking control of the robot's motions. Such models are also necessary for sizing the actuators, tuning the controller, and achieving superior performance. Simulations of various control designs are shown. Also, much of the model has also been used for the actual prototype Bearcat Cub mobile robot. This vision guided robot was designed for the Intelligent Ground Vehicle Contest. A novel feature of the proposed approach is that the method is applicable to both robot arm manipulators and robot bases such as wheeled mobile robots. This generality should encourage the development of more mobile robots with manipulator capability since both models can be easily stored in the dynamic database. The multi task controller also permits wide applications. The use of manipulators and mobile bases with a high-level control are potentially useful for space exploration, certain rescue robots, defense robots, and medical robotics aids.

  9. Adapt or perish--a relentless fight for survival: designing superbugs out of the intensive care unit.

    PubMed

    Colatrella, Sandie; Clair, Jeffrey D

    2014-01-01

    Lethal microorganisms have terrorized man since the beginning of time, killing more human beings than anything else in history. The most infamous epidemic, the Black Death, wiped out almost half the population of Europe. To quote H.G. Wells, "adapt or perish, now as ever, is nature's inexorable imperative." Superbugs are nature's revenge on humans for their ingenuity. For decades antibiotics, which work by honing in on particular bacteria, have been the chief line of defense against infection. There is growing urgency for the judicious assessment of both conventional and innovative strategies with regard to antibiotic use, infection control, molecular detection of pathogens and adequate treatment of multidrug-resistant organisms in hospitals, especially critical care units. Financial restraints, changing demographics, an aging population and the limited introduction of new antibiotics have established an imperative for utilization of goal directed strategies in infection prevention and control. Research and development of both clinical and environmental weapons to combat these adversaries is essential if man is to adapt, not perish, in this fight for survival. This article will provide a snapshot of advances in infection prevention and control, including evidence based design, as they relate to the critical care environment.

  10. Adapt or perish--a relentless fight for survival: designing superbugs out of the intensive care unit.

    PubMed

    Colatrella, Sandie; Clair, Jeffrey D

    2014-01-01

    Lethal microorganisms have terrorized man since the beginning of time, killing more human beings than anything else in history. The most infamous epidemic, the Black Death, wiped out almost half the population of Europe. To quote H.G. Wells, "adapt or perish, now as ever, is nature's inexorable imperative." Superbugs are nature's revenge on humans for their ingenuity. For decades antibiotics, which work by honing in on particular bacteria, have been the chief line of defense against infection. There is growing urgency for the judicious assessment of both conventional and innovative strategies with regard to antibiotic use, infection control, molecular detection of pathogens and adequate treatment of multidrug-resistant organisms in hospitals, especially critical care units. Financial restraints, changing demographics, an aging population and the limited introduction of new antibiotics have established an imperative for utilization of goal directed strategies in infection prevention and control. Research and development of both clinical and environmental weapons to combat these adversaries is essential if man is to adapt, not perish, in this fight for survival. This article will provide a snapshot of advances in infection prevention and control, including evidence based design, as they relate to the critical care environment. PMID:24896557

  11. Temporally Adaptive Sampling: A Case Study in Rare Species Survey Design with Marbled Salamanders (Ambystoma opacum)

    PubMed Central

    Charney, Noah D.; Kubel, Jacob E.; Eiseman, Charles S.

    2015-01-01

    Improving detection rates for elusive species with clumped distributions is often accomplished through adaptive sampling designs. This approach can be extended to include species with temporally variable detection probabilities. By concentrating survey effort in years when the focal species are most abundant or visible, overall detection rates can be improved. This requires either long-term monitoring at a few locations where the species are known to occur or models capable of predicting population trends using climatic and demographic data. For marbled salamanders (Ambystoma opacum) in Massachusetts, we demonstrate that annual variation in detection probability of larvae is regionally correlated. In our data, the difference in survey success between years was far more important than the difference among the three survey methods we employed: diurnal surveys, nocturnal surveys, and dipnet surveys. Based on these data, we simulate future surveys to locate unknown populations under a temporally adaptive sampling framework. In the simulations, when pond dynamics are correlated over the focal region, the temporally adaptive design improved mean survey success by as much as 26% over a non-adaptive sampling design. Employing a temporally adaptive strategy costs very little, is simple, and has the potential to substantially improve the efficient use of scarce conservation funds. PMID:25799224

  12. Temporally adaptive sampling: a case study in rare species survey design with marbled salamanders (Ambystoma opacum).

    PubMed

    Charney, Noah D; Kubel, Jacob E; Eiseman, Charles S

    2015-01-01

    Improving detection rates for elusive species with clumped distributions is often accomplished through adaptive sampling designs. This approach can be extended to include species with temporally variable detection probabilities. By concentrating survey effort in years when the focal species are most abundant or visible, overall detection rates can be improved. This requires either long-term monitoring at a few locations where the species are known to occur or models capable of predicting population trends using climatic and demographic data. For marbled salamanders (Ambystoma opacum) in Massachusetts, we demonstrate that annual variation in detection probability of larvae is regionally correlated. In our data, the difference in survey success between years was far more important than the difference among the three survey methods we employed: diurnal surveys, nocturnal surveys, and dipnet surveys. Based on these data, we simulate future surveys to locate unknown populations under a temporally adaptive sampling framework. In the simulations, when pond dynamics are correlated over the focal region, the temporally adaptive design improved mean survey success by as much as 26% over a non-adaptive sampling design. Employing a temporally adaptive strategy costs very little, is simple, and has the potential to substantially improve the efficient use of scarce conservation funds. PMID:25799224

  13. Temporally adaptive sampling: a case study in rare species survey design with marbled salamanders (Ambystoma opacum).

    PubMed

    Charney, Noah D; Kubel, Jacob E; Eiseman, Charles S

    2015-01-01

    Improving detection rates for elusive species with clumped distributions is often accomplished through adaptive sampling designs. This approach can be extended to include species with temporally variable detection probabilities. By concentrating survey effort in years when the focal species are most abundant or visible, overall detection rates can be improved. This requires either long-term monitoring at a few locations where the species are known to occur or models capable of predicting population trends using climatic and demographic data. For marbled salamanders (Ambystoma opacum) in Massachusetts, we demonstrate that annual variation in detection probability of larvae is regionally correlated. In our data, the difference in survey success between years was far more important than the difference among the three survey methods we employed: diurnal surveys, nocturnal surveys, and dipnet surveys. Based on these data, we simulate future surveys to locate unknown populations under a temporally adaptive sampling framework. In the simulations, when pond dynamics are correlated over the focal region, the temporally adaptive design improved mean survey success by as much as 26% over a non-adaptive sampling design. Employing a temporally adaptive strategy costs very little, is simple, and has the potential to substantially improve the efficient use of scarce conservation funds.

  14. A new adaptive design based on Simon's two-stage optimal design for phase II clinical trials.

    PubMed

    Jin, Hua; Wei, Zhen

    2012-11-01

    Phase II clinical trials are conducted to determine whether a new agent or drug regimen has sufficient promise in treating cancer to merit further testing in larger groups of patients. Both ethical and practical considerations often require early termination of phase II trials if early results clearly indicate that the new regimen is not active or worthy of further investigation. Simon's two-stage designs (1989) are common methods for conducting phase II studies investigating new cancer therapies. Banerjee and Tsiatis (2006) proposed an adaptive two-stage design which allows the sample size at the second stage to depend on the results at the first stage. Their design is more flexible than Simon's, but it is somewhat counter-intuitive: as the response in the first stage increases, the second-stage sample size increases till a certain point and then abruptly becomes zero. In this paper, based on Simon's two-stage optimal design, we propose a new adaptive one which depends on the first stage results using the restrict conditions the conditional type I error and the conditional power. Comparisons are made between Banerjee and Tsiatis' results and our new adaptive designs. PMID:22772088

  15. Optimal Information Representation and Criticality in an Adaptive Sensory Recurrent Neuronal Network

    PubMed Central

    Shriki, Oren; Yellin, Dovi

    2016-01-01

    Recurrent connections play an important role in cortical function, yet their exact contribution to the network computation remains unknown. The principles guiding the long-term evolution of these connections are poorly understood as well. Therefore, gaining insight into their computational role and into the mechanism shaping their pattern would be of great importance. To that end, we studied the learning dynamics and emergent recurrent connectivity in a sensory network model based on a first-principle information theoretic approach. As a test case, we applied this framework to a model of a hypercolumn in the visual cortex and found that the evolved connections between orientation columns have a "Mexican hat" profile, consistent with empirical data and previous modeling work. Furthermore, we found that optimal information representation is achieved when the network operates near a critical point in its dynamics. Neuronal networks working near such a phase transition are most sensitive to their inputs and are thus optimal in terms of information representation. Nevertheless, a mild change in the pattern of interactions may cause such networks to undergo a transition into a different regime of behavior in which the network activity is dominated by its internal recurrent dynamics and does not reflect the objective input. We discuss several mechanisms by which the pattern of interactions can be driven into this supercritical regime and relate them to various neurological and neuropsychiatric phenomena. PMID:26882372

  16. Experiences with an adaptive design for a dose-finding study in patients with osteoarthritis.

    PubMed

    Miller, Frank; Björnsson, Marcus; Svensson, Ola; Karlsten, Rolf

    2014-03-01

    Dose-finding studies in non-oncology areas are usually conducted in Phase II of the development process of a new potential medicine and it is key to choose a good design for such a study, as the results will decide if and how to proceed to Phase III. The present article has focus on the design of a dose-finding study for pain in osteoarthritis patients treated with the TRPV1 antagonist AZD1386. We describe different design alternatives in the planning of this study, the reasoning for choosing the adaptive design and experiences with conduct and interim analysis. Three alternatives were proposed: one single dose-finding study with parallel design, a programme with a smaller Phase IIa study followed by a Phase IIb dose-finding study, and an adaptive dose-finding study. We describe these alternatives in detail and explain why the adaptive design was chosen for the study. We give insights in design aspects of the adaptive study, which need to be pre-planned, like interim decision criteria, statistical analysis method and setup of a Data Monitoring Committee. Based on the interim analysis it was recommended to stop the study for futility since AZD1386 showed no significant pain decrease based on the primary variable. We discuss results and experiences from the conduct of the study with the novel design approach. Huge cost savings have been done compared to if the option with one dose-finding design for Phase II had been chosen. However, we point out several challenges with this approach.

  17. [The short version of Critical Care Family Needs Inventory (CCFNI): adaptation and validation for a spanish sample].

    PubMed

    Gómez-Martíinez, S; Arnal, R Ballester; Juliá, B Gil

    2011-01-01

    Relatives play an important role in the disease process of patients admitted to Intensive Care Units (ICU). It is therefore important to know the needs of people close to the patient in order to try to improve their adaption to a situation as difficult as an ICU admission. The aim of this study was the adaptation and validation of the short version of the Critical Care Family Needs Inventory (CCFNI) for a Spanish sample. The inventory was applied to 55 relatives of patients admitted to the ICU of the Hospital General de Castellón. After the removal of three items for different reasons, we performed an Exploratory Factor Analysis with the 11 remaining items to determine the factor structure of the questionnaire. We also made a descriptive analysis of the items, and internal consistency and construct validity were calculated through Cronbach's α and Pearson correlation coefficient respectively. The results of the principal components factor analysis using varimax rotation indicated a four-factor solution. These four factors corresponded to: medical attention to the patient, personal attention to the relatives, communication between the family and the doctor, and perceived improvements in the Unit. The short version of CCFNI showed good internal consistency for both the total scale and factors. The results suggest that the CCFNI is a suitable measure for assessing the different needs presented by the relatives of patients admitted to an Intensive Care Unit, showing adequate psychometric properties.

  18. Targeted ethnography as a critical step to inform cultural adaptations of HIV prevention interventions for adults with severe mental illness.

    PubMed

    Wainberg, Milton L; Alfredo González, M; McKinnon, Karen; Elkington, Katherine S; Pinto, Diana; Gruber Mann, Claudio; Mattos, Paulo E

    2007-07-01

    As in other countries worldwide, adults with severe mental illness (SMI) in Brazil are disproportionately infected with HIV relative to the general population. Brazilian psychiatric facilities lack tested HIV prevention interventions. To adapt existing interventions, developed only in the US, we conducted targeted ethnography with adults with SMI and staff from two psychiatric institutions in Brazil. We sought to characterize individual, institutional, and interpersonal factors that may affect HIV risk behavior in this population. We conducted 350 hours of ethnographic field observations in two mental health service settings in Rio de Janeiro, and 9 focus groups (n=72) and 16 key-informant interviews with patients and staff in these settings. Data comprised field notes and audiotapes of all exchanges, which were transcribed, coded, and systematically analyzed. The ethnography identified and/or characterized the institutional culture: (1) patients' risk behaviors; (2) the institutional setting; (3) intervention content; and (4) intervention format and delivery strategies. Targeted ethnography also illuminated broader contextual issues for development and implementation of HIV prevention interventions for adults with SMI in Brazil, including an institutional culture that did not systematically address patients' sexual behavior, sexual health, or HIV sexual risk, yet strongly impacted the structure of patients' sexual networks. Further, ethnography identified the Brazilian concept of "social responsibility" as important to prevention work with psychiatric patients. Targeted ethnography with adults with SMI and institutional staff provided information critical to the adaptation of tested US HIV prevention interventions for Brazilians with SMI.

  19. Coupled sensor/platform control design for low-level chemical detection with position-adaptive micro-UAVs

    NASA Astrophysics Data System (ADS)

    Goodwin, Thomas; Carr, Ryan; Mitra, Atindra K.; Selmic, Rastko R.

    2009-05-01

    We discuss the development of Position-Adaptive Sensors [1] for purposes for detecting embedded chemical substances in challenging environments. This concept is a generalization of patented Position-Adaptive Radar Concepts developed at AFRL for challenging conditions such as urban environments. For purposes of investigating the detection of chemical substances using multiple MAV (Micro-UAV) platforms, we have designed and implemented an experimental testbed with sample structures such as wooden carts that contain controlled leakage points. Under this general concept, some of the members of a MAV swarm can serve as external position-adaptive "transmitters" by blowing air over the cart and some of the members of a MAV swarm can serve as external position-adaptive "receivers" that are equipped with chemical or biological (chem/bio) sensors that function as "electronic noses". The objective can be defined as improving the particle count of chem/bio concentrations that impinge on a MAV-based position-adaptive sensor that surrounds a chemical repository, such as a cart, via the development of intelligent position-adaptive control algorithms. The overall effect is to improve the detection and false-alarm statistics of the overall system. Within the major sections of this paper, we discuss a number of different aspects of developing our initial MAV-Based Sensor Testbed. This testbed includes blowers to simulate position-adaptive excitations and a MAV from Draganfly Innovations Inc. with stable design modifications to accommodate our chem/bio sensor boom design. We include details with respect to several critical phases of the development effort including development of the wireless sensor network and experimental apparatus, development of the stable sensor boom for the MAV, integration of chem/bio sensors and sensor node onto the MAV and boom, development of position-adaptive control algorithms and initial tests at IDCAST (Institute for the Development and

  20. Design of computer-generated beam-shaping holograms by iterative finite-element mesh adaption.

    PubMed

    Dresel, T; Beyerlein, M; Schwider, J

    1996-12-10

    Computer-generated phase-only holograms can be used for laser beam shaping, i.e., for focusing a given aperture with intensity and phase distributions into a pregiven intensity pattern in their focal planes. A numerical approach based on iterative finite-element mesh adaption permits the design of appropriate phase functions for the task of focusing into two-dimensional reconstruction patterns. Both the hologram aperture and the reconstruction pattern are covered by mesh mappings. An iterative procedure delivers meshes with intensities equally distributed over the constituting elements. This design algorithm adds new elementary focuser functions to what we call object-oriented hologram design. Some design examples are discussed.

  1. Direct and Inverse Problems of Item Pool Design for Computerized Adaptive Testing

    ERIC Educational Resources Information Center

    Belov, Dmitry I.; Armstrong, Ronald D.

    2009-01-01

    The recent literature on computerized adaptive testing (CAT) has developed methods for creating CAT item pools from a large master pool. Each CAT pool is designed as a set of nonoverlapping forms reflecting the skill levels of an assumed population of test takers. This article presents a Monte Carlo method to obtain these CAT pools and discusses…

  2. Development of an Assistance Environment for Tutors Based on a Co-Adaptive Design Approach

    ERIC Educational Resources Information Center

    Lavoue, Elise; George, Sebastien; Prevot, Patrick

    2012-01-01

    In this article, we present a co-adaptive design approach named TE-Cap (Tutoring Experience Capitalisation) that we applied for the development of an assistance environment for tutors. Since tasks assigned to tutors in educational contexts are not well defined, we are developing an environment which responds to needs which are not precisely…

  3. Can Approaches to Research in Art and Design Be Beneficially Adapted for Research into Higher Education?

    ERIC Educational Resources Information Center

    Trowler, Paul

    2013-01-01

    This paper examines the research practices in Art and Design that are distinctively different from those common in research into higher education outside those fields. It considers whether and what benefit could be derived from their adaptation by the latter. The paper also examines the factors that are conducive and obstructive to adaptive…

  4. Adaptation of G-TAG Software for Validating Touch-and-Go Comet Surface Sampling Design Methodology

    NASA Technical Reports Server (NTRS)

    Mandic, Milan; Acikmese, Behcet; Blackmore, Lars

    2011-01-01

    The G-TAG software tool was developed under the R&TD on Integrated Autonomous Guidance, Navigation, and Control for Comet Sample Return, and represents a novel, multi-body dynamics simulation software tool for studying TAG sampling. The G-TAG multi-body simulation tool provides a simulation environment in which a Touch-and-Go (TAG) sampling event can be extensively tested. TAG sampling requires the spacecraft to descend to the surface, contact the surface with a sampling collection device, and then to ascend to a safe altitude. The TAG event lasts only a few seconds but is mission-critical with potentially high risk. Consequently, there is a need for the TAG event to be well characterized and studied by simulation and analysis in order for the proposal teams to converge on a reliable spacecraft design. This adaptation of the G-TAG tool was developed to support the Comet Odyssey proposal effort, and is specifically focused to address comet sample return missions. In this application, the spacecraft descends to and samples from the surface of a comet. Performance of the spacecraft during TAG is assessed based on survivability and sample collection performance. For the adaptation of the G-TAG simulation tool to comet scenarios, models are developed that accurately describe the properties of the spacecraft, approach trajectories, and descent velocities, as well as the models of the external forces and torques acting on the spacecraft. The adapted models of the spacecraft, descent profiles, and external sampling forces/torques were more sophisticated and customized for comets than those available in the basic G-TAG simulation tool. Scenarios implemented include the study of variations in requirements, spacecraft design (size, locations, etc. of the spacecraft components), and the environment (surface properties, slope, disturbances, etc.). The simulations, along with their visual representations using G-View, contributed to the Comet Odyssey New Frontiers proposal

  5. Design of Critical Control Systems for Non-Minimum Phase Plants via LTR Technique

    NASA Astrophysics Data System (ADS)

    Ishihara, Tadashi; Ono, Takahiko

    An application of the loop transfer recovery (LTR) technique to critical control systems design is proposed for non-minimum phase plants. The controller structure is chosen as the Davison type integral controller with the Kalman filter. First, a critical control system is designed on the assumption that the state of the minimum phase part of the plant can be used for the feedback. A quadratic performance index with tuning parameters is used for determining the partial state feedback gain matrix. Second, the Kalman filter gain matrix is determined such that the output feedback controller performs as in the partial state feedback controller. The formal partial loop recovery procedure using the Riccati equation is adopted for this purpose. The proposed design method requires much simpler numerical search than the conventional one-step approach. An illustrative design example is presented.

  6. Design oriented identification of critical times in transient response. [due to dynamic loads

    NASA Technical Reports Server (NTRS)

    Haftka, R. T.; Watson, L. T.; Grandhi, R. V.

    1984-01-01

    Two techniques are presented for reducing the computational effort in identifying the critical time points. One approach is an adaptive search technique, well suited for the case where the response is exactly known. The other technique, useful for noisy response, is based on a least-squares spline approximation of the response. The possibility of grouping several closely spaced local peaks to identify a single super peak from each group is also investigated. The computational efficiency of the techniques proposed here is illustrated by two examples.

  7. Design of artificial genetic regulatory networks with multiple delayed adaptive responses*

    NASA Astrophysics Data System (ADS)

    Kaluza, Pablo; Inoue, Masayo

    2016-06-01

    Genetic regulatory networks with adaptive responses are widely studied in biology. Usually, models consisting only of a few nodes have been considered. They present one input receptor for activation and one output node where the adaptive response is computed. In this work, we design genetic regulatory networks with many receptors and many output nodes able to produce delayed adaptive responses. This design is performed by using an evolutionary algorithm of mutations and selections that minimizes an error function defined by the adaptive response in signal shapes. We present several examples of network constructions with a predefined required set of adaptive delayed responses. We show that an output node can have different kinds of responses as a function of the activated receptor. Additionally, complex network structures are presented since processing nodes can be involved in several input-output pathways. Supplementary material in the form of one nets file available from the Journal web page at http://dx.doi.org/10.1140/epjb/e2016-70172-9

  8. Analysis and design of a high power laser adaptive phased array transmitter

    NASA Technical Reports Server (NTRS)

    Mevers, G. E.; Soohoo, J. F.; Winocur, J.; Massie, N. A.; Southwell, W. H.; Brandewie, R. A.; Hayes, C. L.

    1977-01-01

    The feasibility of delivering substantial quantities of optical power to a satellite in low earth orbit from a ground based high energy laser (HEL) coupled to an adaptive antenna was investigated. Diffraction effects, atmospheric transmission efficiency, adaptive compensation for atmospheric turbulence effects, including the servo bandwidth requirements for this correction, and the adaptive compensation for thermal blooming were examined. To evaluate possible HEL sources, atmospheric investigations were performed for the CO2, (C-12)(O-18)2 isotope, CO and DF wavelengths using output antenna locations of both sea level and mountain top. Results indicate that both excellent atmospheric and adaption efficiency can be obtained for mountain top operation with a micron isotope laser operating at 9.1 um, or a CO laser operating single line (P10) at about 5.0 (C-12)(O-18)2um, which was a close second in the evaluation. Four adaptive power transmitter system concepts were generated and evaluated, based on overall system efficiency, reliability, size and weight, advanced technology requirements and potential cost. A multiple source phased array was selected for detailed conceptual design. The system uses a unique adaption technique of phase locking independent laser oscillators which allows it to be both relatively inexpensive and most reliable with a predicted overall power transfer efficiency of 53%.

  9. Critical materials: a reason for sustainable education of industrial designers and engineers

    NASA Astrophysics Data System (ADS)

    Köhler, Andreas R.; Bakker, Conny; Peck, David

    2013-08-01

    Developed economies have become highly dependent on a range of technology metals with names such as neodymium and terbium. Stakeholders have warned of the impending scarcity of these critical materials. Difficulties in materials supply can affect the high-tech industries as well as the success of sustainable innovation strategies that are based on sophisticated technology. Industrial designers and engineers should therefore increase their awareness of the limits in availability of critical materials. In this paper, it is argued that materials' criticality can give a fresh impetus to the higher education of industrial design engineers. It is important to train future professionals to apply a systems perspective to the process of technology innovation, enabling them to thrive under circumstances of constrained material choices. The conclusions outline ideas on how to weave the topic into existing educational programmes of future technology developers.

  10. Design and implementation of adaptive PI control schemes for web tension control in roll-to-roll (R2R) manufacturing.

    PubMed

    Raul, Pramod R; Pagilla, Prabhakar R

    2015-05-01

    In this paper, two adaptive Proportional-Integral (PI) control schemes are designed and discussed for control of web tension in Roll-to-Roll (R2R) manufacturing systems. R2R systems are used to transport continuous materials (called webs) on rollers from the unwind roll to the rewind roll. Maintaining web tension at the desired value is critical to many R2R processes such as printing, coating, lamination, etc. Existing fixed gain PI tension control schemes currently used in industrial practice require extensive tuning and do not provide the desired performance for changing operating conditions and material properties. The first adaptive PI scheme utilizes the model reference approach where the controller gains are estimated based on matching of the actual closed-loop tension control systems with an appropriately chosen reference model. The second adaptive PI scheme utilizes the indirect adaptive control approach together with relay feedback technique to automatically initialize the adaptive PI gains. These adaptive tension control schemes can be implemented on any R2R manufacturing system. The key features of the two adaptive schemes is that their designs are simple for practicing engineers, easy to implement in real-time, and automate the tuning process. Extensive experiments are conducted on a large experimental R2R machine which mimics many features of an industrial R2R machine. These experiments include trials with two different polymer webs and a variety of operating conditions. Implementation guidelines are provided for both adaptive schemes. Experimental results comparing the two adaptive schemes and a fixed gain PI tension control scheme used in industrial practice are provided and discussed.

  11. 77 FR 41147 - Endangered and Threatened Wildlife and Plants; Designation of Revised Critical Habitat for the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-12

    ... the Federal Register on August 15, 2011 (76 FR 50542). We are accepting comments regarding additional... flycatcher critical habitat designation (70 FR 60886, October 19, 2005) and lands to be newly considered for... complete and accurate. If you submitted comments or information on the proposed revised rule (76 FR...

  12. Critical Features of Engineering Design in Technology Education. Research in Engineering and Technology Education

    ERIC Educational Resources Information Center

    Asunda, Paul A.; Hill, Roger B.

    2007-01-01

    The purpose of this study was to find critical features of engineering design that can be incorporated within technology education learning activities, and develop a rubric for assessing these features. Data were collected through semi-structured interviews with three professors actively involved in engineering education. Supporting documents such…

  13. 76 FR 2863 - Endangered and Threatened Wildlife and Plants; Designation of Critical Habitat for the Sonoma...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-18

    ... 18, 2009 (74 FR 41662), and announce the availability of the draft economic analysis for the revised..., 2009 (74 FR 41662), our draft economic analysis (DEA) of the proposed designation, and the amended... August 18, 2009 (74 FR 41662), the revisions to proposed critical habitat described herein (see...

  14. Dowsing Rods Designed to Sharpen Critical Thinking and Understanding of Ideomotor Action

    ERIC Educational Resources Information Center

    Lawson, Timothy J.; Crane, Lynda L.

    2014-01-01

    We describe an Introduction to Psychology (IP) demonstration of water dowsing and ideomotor action designed to enhance students' critical thinking. An instructor demonstrated that metal rods crossed over an uncovered cup containing water but not one containing sugar. Student volunteers using the rods also saw them cross over the cup…

  15. 77 FR 16512 - Endangered and Threatened Wildlife and Plants; Designation of Critical Habitat for the Southern...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-21

    ... Fish and Wildlife Service 50 CFR Part 17 RIN 1018-AX38 Endangered and Threatened Wildlife and Plants... previously submitted need not be resubmitted and will be fully considered in preparation of the final rule... caribou. On November 30, 2011, we published a proposed rule (76 FR 74018) to designate critical...

  16. 75 FR 11080 - Endangered and Threatened Wildlife and Plants; Designation of Critical Habitat for Carex lutea

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-10

    ..., refer to the final listing rule published in the Federal Register on January 23, 2002 (67 FR 3120... (65 cm). The species is endemic to Onslow and Pender Counties in the Black River section of the... listed as endangered under the Act on January 23, 2002 (67 FR 3120). Designation of critical habitat...

  17. 78 FR 343 - Endangered and Threatened Wildlife and Plants; Designation of Critical Habitat for Southwestern...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-03

    ... analysis and draft environmental assessment in the Federal Register on July 12, 2012 (77 FR 41147... seq.) on February 27, 1995 (60 FR 10694). On July 22, 1997, we published a final critical habitat designation for the flycatcher along 964 river km (599 river mi) in Arizona, California, and New Mexico (62...

  18. Universal Instructional Design and Critical (Communication) Pedagogy: Strategies for Voice, Inclusion, and Social Justice/Change

    ERIC Educational Resources Information Center

    Johnson, Julia

    2004-01-01

    This essay is written in direct response to Barajas' and Higbee's (2003) call to treat Univer sal Instructional Design (UID) as part of a multicultural educational project. I contend that inclusivity and the use of UID should be combined with the political project of Critical Pedagogy (CP). In so doing, inclusivity will not reproduce the relations…

  19. 77 FR 8449 - Endangered and Threatened Wildlife and Plants; Designation of Critical Habitat for Nine Bexar...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-14

    ... County karst invertebrate species as endangered in the Federal Register on December 30, 1998 (63 FR 71855... invertebrates (67 FR 55063). The final critical habitat rule, designating approximately 1,063 ac (431 ha) in 22... December 26, 2000 (65 FR 81419), and to our September 2011 final recovery plan (Service 2011), which...

  20. 76 FR 53223 - Endangered and Threatened Wildlife and Plants; Designation of Critical Habitat for Astragalus...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-25

    ... Register on October 6, 1998 (63 FR 53596), and the designation of critical habitat for A. l. var. coachellae published in the Federal Register on December 14, 2005 (70 FR 74112). Additionally, information on.... coachellae has remained effectively the same since the taxon was listed as endangered in 1998 (63 FR...

  1. 76 FR 58441 - Endangered and Threatened Wildlife and Plants; Listing and Designation of Critical Habitat for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-21

    ..., 2011 (76 FR 14126), our revised designation of critical habitat provided in this document, our draft...). If you submitted comments or information on the proposed rule (76 FR 14126; March 15, 2011) during... March 15, 2011 (76 FR 14126). For more information on the Chiricahua leopard frog or its habitat,...

  2. 75 FR 74545 - Endangered and Threatened Wildlife and Plants; Final Rule Designating Critical Habitat for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-30

    ..., refer to the final listing rule published in the Federal Register on July 2, 2002 (67 FR 44372), the proposed critical habitat designation published in the Federal Register on August 27, 2009 (74 FR 44238... Register on May 18, 2010 (75 FR 27690). New Information on Species' Description, Life History,...

  3. 75 FR 37350 - Endangered and Threatened Wildlife and Plants; Designation of Critical Habitat for Vermilion Darter

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-29

    ... Federal Register on December 3, 2009 (74 FR 63366), the draft economic analysis (DEA) of the proposed... vermilion darter, previously published on December 3, 2009 (74 FR 63366), you do not have to resubmit them..., 2001 (66 FR 59367). At the time of listing, the Service found that designation of critical habitat...

  4. 78 FR 24007 - Endangered and Threatened Wildlife and Plants; Designation of Critical Habitat for Eriogonum codium

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-23

    ... rule (77 FR 28704), allowing the public to provide comments on our analysis. No comments were received... critical habitat designation or the draft economic analysis. Previous Federal Actions Candidate History... Candidate Notice of Review, published in the Federal Register on October 25, 1999 (64 FR 57542). We refer...

  5. 78 FR 53390 - Endangered and Threatened Wildlife and Plants; Designation of Critical Habitat for the Jaguar

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-29

    ..., 2013, revised proposed rule to designate critical habitat for the jaguar (78 FR 39237), draft economic... for the proposed rule published August 20, 2012 (77 FR 50214), and revised July 1, 2013 (78 FR 39237... FR 50214). That proposal had a 60- day comment period, ending October 19, 2012. On July 1, 2013,...

  6. 78 FR 10449 - Endangered and Threatened Wildlife and Plants; Designation of Critical Habitat for Astragalus...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-13

    ... as an endangered species on October 6, 1998 (63 FR 53596). On August 25, 2011, we published in the Federal Register a proposed critical habitat designation for A. l. var. coachellae (76 FR 53224). Section... FR 28846), allowing the public to provide comments on our analysis. We considered all comments...

  7. 76 FR 9297 - Endangered and Threatened Wildlife and Plants; Proposed Designation of Critical Habitat for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-17

    ..., 2010 (75 FR 35375). In total, we are proposing to designate as critical habitat 520.8 acres (210.8... Register on June 22, 2010, (75 FR 35375), and the additional area proposed in this notice. As a result of.... If you submitted comments or information on the proposed rule (75 FR 35375) during the...

  8. 75 FR 18107 - Endangered and Threatened Wildlife and Plants; Designation of Critical Habitat for Oregon Chub...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-09

    ... INFORMATION: Background Our March 10, 2010, final rule (75 FR 11010) to designate critical habitat for the... (75 FR 11010). For a more complete discussion of the ecology and life history of the species, please see our March 10, 2009, proposed rule (74 FR 10412), and the Oregon Chub 5-year Review Summary...

  9. 78 FR 70001 - Endangered and Threatened Wildlife and Plants; Threatened Status and Designation of Critical...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-22

    ... Umtanum desert buckwheat and White Bluffs bladderpod (77 FR 28704). On July 11, 2013, we held two public... Bluffs Bladderpod)'' (78 FR 23984; April 23, 2013) and ``Designation of Critical Habitat for Eriogonum...)'' (78 FR 24008; April 23, 2013) are delayed until December 20, 2013. ADDRESSES: You may obtain copies...

  10. 78 FR 30772 - Endangered and Threatened Wildlife and Plants; Threatened Status and Designation of Critical...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-23

    ... 78 FR 23983 and 78 FR 24007, are delayed until November 22, 2013. ADDRESSES: You may obtain copies of... Bladderpod)'' (78 FR 23983) and ``Endangered and Threatened Wildlife and Plants; Designation of Critical... Bluffs Bladderpod)'' (78 FR 24007). The listing final rule implements the Federal protections provided...

  11. 78 FR 49165 - Endangered and Threatened Wildlife and Plants; Designation of Critical Habitat for Sphaeralcea...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-13

    ... critical habitat designation for Gierisch mallow (77 FR 49894). Section 4(b)(2) of the Act states that the... (DEA) in the Federal Register on March 28, 2013 (78 FR 18943), allowing the public to provide comments... availability of the draft environmental assessment in the Federal Register on March 28, 2013 (78 FR...

  12. 77 FR 32909 - Listing Endangered and Threatened Wildlife and Designating Critical Habitat; 12-Month...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-04

    ... of 1969, a precursor to the ESA (35 FR 8491). Leatherback sea turtles are the largest living turtles... recently, we designated critical habitat for leatherback sea turtles in the Pacific Ocean (77 FR 4170... for leatherback sea turtles in the Pacific Ocean (75 FR 319; January 5, 2010) as support for...

  13. 77 FR 32075 - Endangered and Threatened Wildlife and Plants; Designation of Critical Habitat for the Southern...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-31

    ... FR 74018), our draft economic analysis of the proposed designation, and the amended required...- and-answer period), and a public hearing on April 28, 2012, in Bonners Ferry, Idaho (77 FR 16512... proposed critical habitat rule, as described below. Previous Federal Actions On November 30, 2011 (76...

  14. 78 FR 52363 - Endangered and Threatened Wildlife and Plants; Designation of Critical Habitat for the Diamond...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-22

    ... the diamond darter as an endangered species on July 26, 2013 (78 FR 45074). On July 26, 2012, we published in the Federal Register a proposed critical habitat designation for the diamond darter (77 FR... Register on March 29, 2013 (78 FR 19172), allowing the public to provide comments on our analysis. We...

  15. 75 FR 66481 - Endangered and Threatened Wildlife and Plants; Endangered Status and Designation of Critical...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-28

    ... rule (51 FR 23769, July 1, 1986 (spikedace), and 51 FR 39468, October 28, 1986 (loach minnow)) and the previous critical habitat designation (72 FR 13356, March 21, 2007). Spikedace The spikedace is a member of... document. Previous Federal Actions The spikedace was listed as threatened on July 1, 1986 (51 FR...

  16. 77 FR 10809 - Endangered and Threatened Wildlife and Plants; Endangered Status and Designations of Critical...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-23

    ... spikedace (51 FR 23769), and October 28, 1986, for loach minnow (51 FR 39468); the previous critical habitat designations (72 FR 13356, March 21, 2007); and our 1991 final recovery plans, which are available from the... the Federal Register on October 28, 2010 (75 FR 66482). A notice of availability regarding changes...

  17. 76 FR 11086 - Endangered and Threatened Wildlife and Plants; Designation of Critical Habitat for Carex lutea

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-01

    ... Register on January 23, 2002 (67 FR 3120). Information on the associated draft economic analysis (DEA) for..., 2010 (75 FR 45592). Species Description, Life History, Distribution, Ecology and Habitat Carex lutea is... endangered under the Act on January 23, 2002 (67 FR 3120). Designation of critical habitat had been found...

  18. Critical Perspectives on TEL: Art and Design Education, Theory, Communities and Space

    ERIC Educational Resources Information Center

    Sclater, Madeleine; Lally, Vic

    2016-01-01

    This paper explores three themes, emerging from the Inter-Life project, an Art and Design education and social skills project set in a virtual world. We argue that they connect with the concerns raised by critical Technology-Enhanced Learning (TEL) researchers at the Alpine Rendezvous workshop entitled "TEL: the Crisis and the Response."…

  19. Universal Design for Learning: Critical Need Areas for People with Learning Disabilities

    ERIC Educational Resources Information Center

    Strobel, Wendy; Arthanat, Sajay; Bauer, Stephen; Flagg, Jennifer

    2007-01-01

    The primary market research outlined in this paper was conducted by the Rehabilitation Engineering Research Center on Technology Transfer to identify critical technology needs for people with learning disabilities. Based on the research conducted, the underlying context of these technology needs is Universal Design for Learning (UDL). The paper…

  20. The Impact of Critical Thinking and Logico-Mathematical Intelligence on Algorithmic Design Skills

    ERIC Educational Resources Information Center

    Korkmaz, Ozgen

    2012-01-01

    The present study aims to reveal the impact of students' critical thinking and logico-mathematical intelligence levels of students on their algorithm design skills. This research was a descriptive study and carried out by survey methods. The sample consisted of 45 first-year educational faculty undergraduate students. The data was collected by…

  1. 43 CFR 1610.7-2 - Designation of areas of critical environmental concern.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., PROGRAMMING, BUDGETING Resource Management Planning § 1610.7-2 Designation of areas of critical environmental... protection management shall be identified and considered throughout the resource management planning process... fish or wildlife resource or other natural system or process; or natural hazard. (2) Importance....

  2. 75 FR 1568 - Endangered and Threatened Wildlife and Plants; Proposed Designation of Critical Habitat for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-12

    ..., including school boards and city and town governments that serve fewer than ] 50,000 residents; and small... Fish and Wildlife Service 50 CFR Part 17 Endangered and Threatened Wildlife and Plants; Proposed...), announce the reopening of the comment period on the proposed designation of critical habitat for two...

  3. 77 FR 73739 - Endangered and Threatened Wildlife and Plants; Designation of Critical Habitat for Lost River...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-11

    ... Wildlife Service (Service), listed these two species as endangered on July 18, 1988 (53 FR 27130). On... River sucker and shortnose sucker (59 FR 61744); that proposal was never finalized. On December 7, 2011, we published a revised proposed critical habitat designation in the Federal Register (76 FR...

  4. 78 FR 17999 - Endangered and Threatened Wildlife and Plants; Designation of Critical Habitat for the Northwest...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-25

    ... the Act as a threatened species on July 28, 1978 (43 FR 32800). No critical habitat was designated for.... NMFS published a notice in the Federal Register on November 16, 2007 (72 FR 64585), concluding that the... Federal Register on March 5, 2008 (73 FR 11849), concluding that the petition presented...

  5. 78 FR 69569 - Endangered and Threatened Wildlife and Plants; Designation of Critical Habitat for the Jemez...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-20

    ... 10, 2013 (78 FR 55599). This is a final rule to designate critical habitat for the Jemez Mountains... Federal Register on February 12, 2013 (78 FR 9876), allowing the public to provide comments on our... on September 10, 2013 (78 FR 55599). Background The Jemez Mountains salamander is restricted to...

  6. Design and progress toward a multi-conjugate adaptive optics system for distributed aberration correction

    SciTech Connect

    Baker, K; Olivier, S; Tucker, J; Silva, D; Gavel, D; Lim, R; Gratrix, E

    2004-08-17

    This article investigates the use of a multi-conjugate adaptive optics system to improve the field-of-view for the system. The emphasis of this research is to develop techniques to improve the performance of optical systems with applications to horizontal imaging. The design and wave optics simulations of the proposed system are given. Preliminary results from the multi-conjugate adaptive optics system are also presented. The experimental system utilizes a liquid-crystal spatial light modulator and an interferometric wave-front sensor for correction and sensing of the phase aberrations, respectively.

  7. Adjoint-Based Algorithms for Adaptation and Design Optimizations on Unstructured Grids

    NASA Technical Reports Server (NTRS)

    Nielsen, Eric J.

    2006-01-01

    Schemes based on discrete adjoint algorithms present several exciting opportunities for significantly advancing the current state of the art in computational fluid dynamics. Such methods provide an extremely efficient means for obtaining discretely consistent sensitivity information for hundreds of design variables, opening the door to rigorous, automated design optimization of complex aerospace configuration using the Navier-Stokes equation. Moreover, the discrete adjoint formulation provides a mathematically rigorous foundation for mesh adaptation and systematic reduction of spatial discretization error. Error estimates are also an inherent by-product of an adjoint-based approach, valuable information that is virtually non-existent in today's large-scale CFD simulations. An overview of the adjoint-based algorithm work at NASA Langley Research Center is presented, with examples demonstrating the potential impact on complex computational problems related to design optimization as well as mesh adaptation.

  8. Design and inference for the intent-to-treat principle using adaptive treatment.

    PubMed

    Dawson, Ree; Lavori, Philip W

    2015-04-30

    Nonadherence to assigned treatment jeopardizes the power and interpretability of intent-to-treat comparisons from clinical trial data and continues to be an issue for effectiveness studies, despite their pragmatic emphasis. We posit that new approaches to design need to complement developments in methods for causal inference to address nonadherence, in both experimental and practice settings. This paper considers the conventional study design for psychiatric research and other medical contexts, in which subjects are randomized to treatments that are fixed throughout the trial and presents an alternative that converts the fixed treatments into an adaptive intervention that reflects best practice. The key element is the introduction of an adaptive decision point midway into the study to address a patient's reluctance to remain on treatment before completing a full-length trial of medication. The clinical uncertainty about the appropriate adaptation prompts a second randomization at the new decision point to evaluate relevant options. Additionally, the standard 'all-or-none' principal stratification (PS) framework is applied to the first stage of the design to address treatment discontinuation that occurs too early for a midtrial adaptation. Drawing upon the adaptive intervention features, we develop assumptions to identify the PS causal estimand and to introduce restrictions on outcome distributions to simplify expectation-maximization calculations. We evaluate the performance of the PS setup, with particular attention to the role played by a binary covariate. The results emphasize the importance of collecting covariate data for use in design and analysis. We consider the generality of our approach beyond the setting of psychiatric research. PMID:25581413

  9. Design and inference for the intent-to-treat principle using adaptive treatment.

    PubMed

    Dawson, Ree; Lavori, Philip W

    2015-04-30

    Nonadherence to assigned treatment jeopardizes the power and interpretability of intent-to-treat comparisons from clinical trial data and continues to be an issue for effectiveness studies, despite their pragmatic emphasis. We posit that new approaches to design need to complement developments in methods for causal inference to address nonadherence, in both experimental and practice settings. This paper considers the conventional study design for psychiatric research and other medical contexts, in which subjects are randomized to treatments that are fixed throughout the trial and presents an alternative that converts the fixed treatments into an adaptive intervention that reflects best practice. The key element is the introduction of an adaptive decision point midway into the study to address a patient's reluctance to remain on treatment before completing a full-length trial of medication. The clinical uncertainty about the appropriate adaptation prompts a second randomization at the new decision point to evaluate relevant options. Additionally, the standard 'all-or-none' principal stratification (PS) framework is applied to the first stage of the design to address treatment discontinuation that occurs too early for a midtrial adaptation. Drawing upon the adaptive intervention features, we develop assumptions to identify the PS causal estimand and to introduce restrictions on outcome distributions to simplify expectation-maximization calculations. We evaluate the performance of the PS setup, with particular attention to the role played by a binary covariate. The results emphasize the importance of collecting covariate data for use in design and analysis. We consider the generality of our approach beyond the setting of psychiatric research.

  10. Instructional Design as Critical and Creative Thinking: A Journey through a Jamestown-Era Native American Village

    ERIC Educational Resources Information Center

    Baum, Liesl M.; Newbill, Phyllis Leary

    2010-01-01

    The role of critical and creative thinking has been debated within the field of instructional design. Through an instructional design and development project we have identified how critical and creative thinking are essential to the instructional design process. This paper highlights a recent project focused on a virtual Native American village…

  11. Adaptive sampling in two-phase designs: a biomarker study for progression in arthritis

    PubMed Central

    McIsaac, Michael A; Cook, Richard J

    2015-01-01

    Response-dependent two-phase designs are used increasingly often in epidemiological studies to ensure sampling strategies offer good statistical efficiency while working within resource constraints. Optimal response-dependent two-phase designs are difficult to implement, however, as they require specification of unknown parameters. We propose adaptive two-phase designs that exploit information from an internal pilot study to approximate the optimal sampling scheme for an analysis based on mean score estimating equations. The frequency properties of estimators arising from this design are assessed through simulation, and they are shown to be similar to those from optimal designs. The design procedure is then illustrated through application to a motivating biomarker study in an ongoing rheumatology research program. Copyright © 2015 © 2015 The Authors. Statistics in Medicine Published by John Wiley & Sons Ltd. PMID:25951124

  12. The influence of stem design on critical squeaking friction with ceramic bearings.

    PubMed

    Fan, Na; Morlock, Michael M; Bishop, Nicholas E; Huber, Gerd; Hoffmann, Norbert; Ciavarella, Michele; Chen, Guang X; Hothan, Arne; Witt, Florian

    2013-10-01

    Ceramic-on-ceramic hip joints have been reported to squeak, a phenomenon that may occur in compromised lubrication conditions. One factor related to the incidence of in vivo squeaking is the stem design. However, it has not yet been possible to relate stem design to squeaking in deteriorating lubrication conditions. The purpose of this study was to determine critical friction factors for different stem designs. A hip simulator was used to measure the friction factor of a ceramic bearing with different stem designs and gradually deteriorating lubrication represented by evaporation of a volatile fluid lubricant. The critical squeaking friction factor was measured at the onset of squeaking for each stem. Critical friction was higher for the long cobalt chrome (0.32 ± 0.02) and short titanium stems (0.39 ± 0.02) in comparison with a long titanium stem (0.29 ± 0.02). The onset of squeaking occurred at a friction factor lower than that measured for dry conditions, in which squeaking is usually investigated experimentally. The results suggest that shorter or heavier stems might limit the possibility of squeaking as lubrication deteriorates. The method developed can be used to investigate the influence of design parameters on squeaking probability.

  13. System Guidelines for EMC Safety-Critical Circuits: Design, Selection, and Margin Demonstration

    NASA Technical Reports Server (NTRS)

    Lawton, R. M.

    1996-01-01

    Demonstration of required safety margins on critical electrical/electronic circuits in large complex systems has become an implementation and cost problem. These margins are the difference between the activation level of the circuit and the electrical noise on the circuit in the actual operating environment. This document discusses the origin of the requirement and gives a detailed process flow for the identification of the system electromagnetic compatibility (EMC) critical circuit list. The process flow discusses the roles of engineering disciplines such as systems engineering, safety, and EMC. Design and analysis guidelines are provided to assist the designer in assuring the system design has a high probability of meeting the margin requirements. Examples of approaches used on actual programs (Skylab and Space Shuttle Solid Rocket Booster) are provided to show how variations of the approach can be used successfully.

  14. Design Framework for an Adaptive MOOC Enhanced by Blended Learning: Supplementary Training and Personalized Learning for Teacher Professional Development

    ERIC Educational Resources Information Center

    Gynther, Karsten

    2016-01-01

    The research project has developed a design framework for an adaptive MOOC that complements the MOOC format with blended learning. The design framework consists of a design model and a series of learning design principles which can be used to design in-service courses for teacher professional development. The framework has been evaluated by…

  15. An Integrated Systems Approach to Designing Climate Change Adaptation Policy in Water Resources

    NASA Astrophysics Data System (ADS)

    Ryu, D.; Malano, H. M.; Davidson, B.; George, B.

    2014-12-01

    Climate change projections are characterised by large uncertainties with rainfall variability being the key challenge in designing adaptation policies. Climate change adaptation in water resources shows all the typical characteristics of 'wicked' problems typified by cognitive uncertainty as new scientific knowledge becomes available, problem instability, knowledge imperfection and strategic uncertainty due to institutional changes that inevitably occur over time. Planning that is characterised by uncertainties and instability requires an approach that can accommodate flexibility and adaptive capacity for decision-making. An ability to take corrective measures in the event that scenarios and responses envisaged initially derive into forms at some future stage. We present an integrated-multidisciplinary and comprehensive framework designed to interface and inform science and decision making in the formulation of water resource management strategies to deal with climate change in the Musi Catchment of Andhra Pradesh, India. At the core of this framework is a dialogue between stakeholders, decision makers and scientists to define a set of plausible responses to an ensemble of climate change scenarios derived from global climate modelling. The modelling framework used to evaluate the resulting combination of climate scenarios and adaptation responses includes the surface and groundwater assessment models (SWAT & MODFLOW) and the water allocation modelling (REALM) to determine the water security of each adaptation strategy. Three climate scenarios extracted from downscaled climate models were selected for evaluation together with four agreed responses—changing cropping patterns, increasing watershed development, changing the volume of groundwater extraction and improving irrigation efficiency. Water security in this context is represented by the combination of level of water availability and its associated security of supply for three economic activities (agriculture

  16. Cryogenic design of the liquid helium experiment ``critical dynamics in microgravity``

    SciTech Connect

    Moeur, W.A.; Adriaans, M.J.; Boyd, S.T.; Strayer, D.M.; Duncan, R.V. |

    1995-10-01

    Although many well controlled experiments have been conducted to measure the static properties of systems near criticality, few experiments have explored the transport properties in systems driven far away from equilibrium as a phase transition occurs. The cryogenic design of an experiment to study the dynamic aspect of critical phenomena is reported here. Measurements of the thermal gradient across the superfluid (He II) -- normal fluid (He I) interface in helium under microgravity conditions will be performed as a heat flux holds the system away from equilibrium. New technologies are under development for this experiment, which is in the definition phase for a space shuttle flight.

  17. 75 FR 8968 - Draft Guidance for Industry on Adaptive Design Clinical Trials for Drugs and Biologics; Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-26

    ... design clinical trials (i.e., clinical, statistical, regulatory) call for special consideration, when to interact with FDA while planning and conducting adaptive design studies, what information to include in the... study. The draft guidance is intended to assist sponsors in planning and conducting adaptive...

  18. Dynamic experiment design regularization approach to adaptive imaging with array radar/SAR sensor systems.

    PubMed

    Shkvarko, Yuriy; Tuxpan, José; Santos, Stewart

    2011-01-01

    We consider a problem of high-resolution array radar/SAR imaging formalized in terms of a nonlinear ill-posed inverse problem of nonparametric estimation of the power spatial spectrum pattern (SSP) of the random wavefield scattered from a remotely sensed scene observed through a kernel signal formation operator and contaminated with random Gaussian noise. First, the Sobolev-type solution space is constructed to specify the class of consistent kernel SSP estimators with the reproducing kernel structures adapted to the metrics in such the solution space. Next, the "model-free" variational analysis (VA)-based image enhancement approach and the "model-based" descriptive experiment design (DEED) regularization paradigm are unified into a new dynamic experiment design (DYED) regularization framework. Application of the proposed DYED framework to the adaptive array radar/SAR imaging problem leads to a class of two-level (DEED-VA) regularized SSP reconstruction techniques that aggregate the kernel adaptive anisotropic windowing with the projections onto convex sets to enforce the consistency and robustness of the overall iterative SSP estimators. We also show how the proposed DYED regularization method may be considered as a generalization of the MVDR, APES and other high-resolution nonparametric adaptive radar sensing techniques. A family of the DYED-related algorithms is constructed and their effectiveness is finally illustrated via numerical simulations.

  19. Dynamic Experiment Design Regularization Approach to Adaptive Imaging with Array Radar/SAR Sensor Systems

    PubMed Central

    Shkvarko, Yuriy; Tuxpan, José; Santos, Stewart

    2011-01-01

    We consider a problem of high-resolution array radar/SAR imaging formalized in terms of a nonlinear ill-posed inverse problem of nonparametric estimation of the power spatial spectrum pattern (SSP) of the random wavefield scattered from a remotely sensed scene observed through a kernel signal formation operator and contaminated with random Gaussian noise. First, the Sobolev-type solution space is constructed to specify the class of consistent kernel SSP estimators with the reproducing kernel structures adapted to the metrics in such the solution space. Next, the “model-free” variational analysis (VA)-based image enhancement approach and the “model-based” descriptive experiment design (DEED) regularization paradigm are unified into a new dynamic experiment design (DYED) regularization framework. Application of the proposed DYED framework to the adaptive array radar/SAR imaging problem leads to a class of two-level (DEED-VA) regularized SSP reconstruction techniques that aggregate the kernel adaptive anisotropic windowing with the projections onto convex sets to enforce the consistency and robustness of the overall iterative SSP estimators. We also show how the proposed DYED regularization method may be considered as a generalization of the MVDR, APES and other high-resolution nonparametric adaptive radar sensing techniques. A family of the DYED-related algorithms is constructed and their effectiveness is finally illustrated via numerical simulations. PMID:22163859

  20. Validation of FSP Reactor Design with Sensitivity Studies of Beryllium-Reflected Critical Assemblies

    SciTech Connect

    John D. Bess; Margaret A. Marshall

    2013-02-01

    The baseline design for space nuclear power is a fission surface power (FSP) system: sodium-potassium (NaK) cooled, fast spectrum reactor with highly-enriched-uranium (HEU)-O2 fuel, stainless steel (SS) cladding, and beryllium reflectors with B4C control drums. Previous studies were performed to evaluate modeling capabilities and quantify uncertainties and biases associated with analysis methods and nuclear data. Comparison of Zero Power Plutonium Reactor (ZPPR)-20 benchmark experiments with the FSP design indicated that further reduction of the total design model uncertainty requires the reduction in uncertainties pertaining to beryllium and uranium cross-section data. Further comparison with three beryllium-reflected HEU-metal benchmark experiments performed at the Oak Ridge Critical Experiments Facility (ORCEF) concluded the requirement that experimental validation data have similar cross section sensitivities to those found in the FSP design. A series of critical experiments was performed at ORCEF in the 1960s to support the Medium Power Reactor Experiment (MPRE) space reactor design. The small, compact critical assembly (SCCA) experiments were graphite- or beryllium-reflected assemblies of SS-clad, HEU-O2 fuel on a vertical lift machine. All five configurations were evaluated as benchmarks. Two of the five configurations were beryllium reflected, and further evaluated using the sensitivity and uncertainty analysis capabilities of SCALE 6.1. Validation of the example FSP design model was successful in reducing the primary uncertainty constituent, the Be(n,n) reaction, from 0.28 %dk/k to 0.0004 %dk/k. Further assessment of additional reactor physics measurements performed on the SCCA experiments may serve to further validate FSP design and operation.

  1. Initial conceptual design study of self-critical nuclear pumped laser systems

    NASA Technical Reports Server (NTRS)

    Rodgers, R. J.

    1979-01-01

    An analytical study of self-critical nuclear pumped laser system concepts was performed. Primary emphasis was placed on reactor concepts employing gaseous uranium hexafluoride (UF6) as the fissionable material. Relationships were developed between the key reactor design parameters including reactor power level, critical mass, neutron flux level, reactor size, operating pressure, and UF6 optical properties. The results were used to select a reference conceptual laser system configuration. In the reference configuration, the 3.2 m cubed lasing volume is surrounded by a graphite internal moderator and a region of heavy water. Results of neutronics calculations yield a critical mass of 4.9 U(235) in the form (235)UF6. The configuration appears capable of operating in a continuous steady-state mode. The average gas temperature in the core is 600 K and the UF6 partial pressure within the lasing volume is 0.34 atm.

  2. Add-on simple adaptive control improves performance of classical control design

    NASA Astrophysics Data System (ADS)

    Weiss, Haim; Rusnak, Ilan

    2014-12-01

    The Simple Adaptive Control (SAC) controls an augmented plant that comprises the true plant with parallel feed-forward. The Almost Strictly Positive Real (ASPR) property of the augmented plant leads to asymptotic following. Prior publications have shown that, based only on the prior knowledge on stabilizability properties of systems (usually available), the parallel feed-forward configuration (PFC) allows adaptive control of realistic systems, even if they are both unstable and non-minimum phase. However, it was commonly thought that the PFC addition requires a price when compared with good linear time invariant (LTI) designs that do not use any addition to the plant. The paper shows that the use of SAC with PFC as Add-On to LTI system design improves the performance. Although SAC directly controls the augmented error, it always gives improved performance, i.e., smaller tracking error and reduced sensitivity to plant disturbance, with respect to the best LTI controller.

  3. Local Laser Strengthening of Steel Sheets for Load Adapted Component Design in Car Body Structures

    NASA Astrophysics Data System (ADS)

    Jahn, Axel; Heitmanek, Marco; Standfuss, Jens; Brenner, Berndt; Wunderlich, Gerd; Donat, Bernd

    The current trend in car body construction concerning light weight design and car safety improvement increasingly requires an adaption of the local material properties on the component load. Martensitic hardenable steels, which are typically used in car body components, show a significant hardening effect, for instance in laser welded seams. This effect can be purposefully used as a local strengthening method. For several steel grades the local strengthening, resulting from a laser remelting process was investigated. The strength in the treated zone was determined at crash relevant strain rates. A load adapted design of complex reinforcement structures was developed for compression and bending loaded tube samples, using numerical simulation of the deformation behavior. Especially for bending loaded parts, the crash energy absorption can be increased significantly by local laser strengthening.

  4. Design of Unstructured Adaptive (UA) NAS Parallel Benchmark Featuring Irregular, Dynamic Memory Accesses

    NASA Technical Reports Server (NTRS)

    Feng, Hui-Yu; VanderWijngaart, Rob; Biswas, Rupak; Biegel, Bryan (Technical Monitor)

    2001-01-01

    We describe the design of a new method for the measurement of the performance of modern computer systems when solving scientific problems featuring irregular, dynamic memory accesses. The method involves the solution of a stylized heat transfer problem on an unstructured, adaptive grid. A Spectral Element Method (SEM) with an adaptive, nonconforming mesh is selected to discretize the transport equation. The relatively high order of the SEM lowers the fraction of wall clock time spent on inter-processor communication, which eases the load balancing task and allows us to concentrate on the memory accesses. The benchmark is designed to be three-dimensional. Parallelization and load balance issues of a reference implementation will be described in detail in future reports.

  5. An isoform of Nedd4-2 is critically involved in the renal adaptation to high salt intake in mice

    PubMed Central

    Minegishi, Shintaro; Ishigami, Tomoaki; Kino, Tabito; Chen, Lin; Nakashima-Sasaki, Rie; Araki, Naomi; Yatsu, Keisuke; Fujita, Megumi; Umemura, Satoshi

    2016-01-01

    Epithelial sodium channels (ENaCs) play critical roles in the maintenance of fluid and electrolyte homeostasis, and their genetic abnormalities cause one type of hereditary salt-sensitive hypertension, Liddle syndrome. As we reported previously, both human and rodent Nedd4L/Nedd4-2 showed molecular diversity, with and without a C2 domain in their N-terminal. Nedd4L/Nedd4-2 isoforms with a C2 domain are hypothesized to be related closely to ubiquitination of ENaCs. We generated Nedd4-2 C2 domain knockout mice. We demonstrate here that loss of Nedd4-2 C2 isoform causes salt-sensitive hypertension under conditions of a high dietary salt intake in vivo. The knockout mice had reduced urinary sodium excretion, osmotic pressure and increased water intake and urine volume with marked dilatation of cortical tubules while receiving a high salt diet. To the contrary, there was no difference in metabolic data between wild-type and knockout mice receiving a normal control diet. In the absence of Nedd4-2 C2 domain, a high salt intake accelerated ENaC expression. Coimmunoprecipitation studies revealed suppressed ubiquitination for ENaC with a high salt intake. Taken together, our findings demonstrate that during a high oral salt intake the Nedd4-2 C2 protein plays a pivotal role in maintaining adaptive salt handling in the kidney. PMID:27256588

  6. An isoform of Nedd4-2 is critically involved in the renal adaptation to high salt intake in mice.

    PubMed

    Minegishi, Shintaro; Ishigami, Tomoaki; Kino, Tabito; Chen, Lin; Nakashima-Sasaki, Rie; Araki, Naomi; Yatsu, Keisuke; Fujita, Megumi; Umemura, Satoshi

    2016-01-01

    Epithelial sodium channels (ENaCs) play critical roles in the maintenance of fluid and electrolyte homeostasis, and their genetic abnormalities cause one type of hereditary salt-sensitive hypertension, Liddle syndrome. As we reported previously, both human and rodent Nedd4L/Nedd4-2 showed molecular diversity, with and without a C2 domain in their N-terminal. Nedd4L/Nedd4-2 isoforms with a C2 domain are hypothesized to be related closely to ubiquitination of ENaCs. We generated Nedd4-2 C2 domain knockout mice. We demonstrate here that loss of Nedd4-2 C2 isoform causes salt-sensitive hypertension under conditions of a high dietary salt intake in vivo. The knockout mice had reduced urinary sodium excretion, osmotic pressure and increased water intake and urine volume with marked dilatation of cortical tubules while receiving a high salt diet. To the contrary, there was no difference in metabolic data between wild-type and knockout mice receiving a normal control diet. In the absence of Nedd4-2 C2 domain, a high salt intake accelerated ENaC expression. Coimmunoprecipitation studies revealed suppressed ubiquitination for ENaC with a high salt intake. Taken together, our findings demonstrate that during a high oral salt intake the Nedd4-2 C2 protein plays a pivotal role in maintaining adaptive salt handling in the kidney. PMID:27256588

  7. The development and testing of a qualitative instrument designed to assess critical thinking

    NASA Astrophysics Data System (ADS)

    Clauson, Cynthia Louisa

    This study examined a qualitative approach to assess critical thinking. An instrument was developed that incorporates an assessment process based on Dewey's (1933) concepts of self-reflection and critical thinking as problem solving. The study was designed to pilot test the critical thinking assessment process with writing samples collected from a heterogeneous group of students. The pilot test included two phases. Phase 1 was designed to determine the validity and inter-rater reliability of the instrument using two experts in critical thinking, problem solving, and literacy development. Validity of the instrument was addressed by requesting both experts to respond to ten questions in an interview. The inter-rater reliability was assessed by analyzing the consistency of the two experts' scorings of the 20 writing samples to each other, as well as to my scoring of the same 20 writing samples. Statistical analyses included the Spearman Rho and the Kuder-Richardson (Formula 20). Phase 2 was designed to determine the validity and reliability of the critical thinking assessment process with seven science teachers. Validity was addressed by requesting the teachers to respond to ten questions in a survey and interview. Inter-rater reliability was addressed by comparing the seven teachers' scoring of five writing samples with my scoring of the same five writing samples. Again, the Spearman Rho and the Kuder-Richardson (Formula 20) were used to determine the inter-rater reliability. The validity results suggest that the instrument is helpful as a guide for instruction and provides a systematic method to teach and assess critical thinking while problem solving with students in the classroom. The reliability results show the critical thinking assessment instrument to possess fairly high reliability when used by the experts, but weak reliability when used by classroom teachers. A major conclusion was drawn that teachers, as well as students, would need to receive instruction

  8. A reference model for model-based design of critical infrastructure protection systems

    NASA Astrophysics Data System (ADS)

    Shin, Young Don; Park, Cheol Young; Lee, Jae-Chon

    2015-05-01

    Today's war field environment is getting versatile as the activities of unconventional wars such as terrorist attacks and cyber-attacks have noticeably increased lately. The damage caused by such unconventional wars has also turned out to be serious particularly if targets are critical infrastructures that are constructed in support of banking and finance, transportation, power, information and communication, government, and so on. The critical infrastructures are usually interconnected to each other and thus are very vulnerable to attack. As such, to ensure the security of critical infrastructures is very important and thus the concept of critical infrastructure protection (CIP) has come. The program to realize the CIP at national level becomes the form of statute in each country. On the other hand, it is also needed to protect each individual critical infrastructure. The objective of this paper is to study on an effort to do so, which can be called the CIP system (CIPS). There could be a variety of ways to design CIPS's. Instead of considering the design of each individual CIPS, a reference model-based approach is taken in this paper. The reference model represents the design of all the CIPS's that have many design elements in common. In addition, the development of the reference model is also carried out using a variety of model diagrams. The modeling language used therein is the systems modeling language (SysML), which was developed and is managed by Object Management Group (OMG) and a de facto standard. Using SysML, the structure and operational concept of the reference model are designed to fulfil the goal of CIPS's, resulting in the block definition and activity diagrams. As a case study, the operational scenario of the nuclear power plant while being attacked by terrorists is studied using the reference model. The effectiveness of the results is also analyzed using multiple analysis models. It is thus expected that the approach taken here has some merits

  9. Building Adaptive Game-Based Learning Resources: The Integration of IMS Learning Design and

    ERIC Educational Resources Information Center

    Burgos, Daniel; Moreno-Ger, Pablo; Sierra, Jose Luis; Fernandez-Manjon, Baltasar; Specht, Marcus; Koper, Rob

    2008-01-01

    IMS Learning Design (IMS-LD) is a specification to create units of learning (UoLs), which express a certain pedagogical model or strategy (e.g., adaptive learning with games). However, the authoring process of a UoL remains difficult because of the lack of high-level authoring tools for IMS-LD, even more so when the focus is on specific topics,…

  10. Robust Brain-Machine Interface Design Using Optimal Feedback Control Modeling and Adaptive Point Process Filtering

    PubMed Central

    Carmena, Jose M.

    2016-01-01

    Much progress has been made in brain-machine interfaces (BMI) using decoders such as Kalman filters and finding their parameters with closed-loop decoder adaptation (CLDA). However, current decoders do not model the spikes directly, and hence may limit the processing time-scale of BMI control and adaptation. Moreover, while specialized CLDA techniques for intention estimation and assisted training exist, a unified and systematic CLDA framework that generalizes across different setups is lacking. Here we develop a novel closed-loop BMI training architecture that allows for processing, control, and adaptation using spike events, enables robust control and extends to various tasks. Moreover, we develop a unified control-theoretic CLDA framework within which intention estimation, assisted training, and adaptation are performed. The architecture incorporates an infinite-horizon optimal feedback-control (OFC) model of the brain’s behavior in closed-loop BMI control, and a point process model of spikes. The OFC model infers the user’s motor intention during CLDA—a process termed intention estimation. OFC is also used to design an autonomous and dynamic assisted training technique. The point process model allows for neural processing, control and decoder adaptation with every spike event and at a faster time-scale than current decoders; it also enables dynamic spike-event-based parameter adaptation unlike current CLDA methods that use batch-based adaptation on much slower adaptation time-scales. We conducted closed-loop experiments in a non-human primate over tens of days to dissociate the effects of these novel CLDA components. The OFC intention estimation improved BMI performance compared with current intention estimation techniques. OFC assisted training allowed the subject to consistently achieve proficient control. Spike-event-based adaptation resulted in faster and more consistent performance convergence compared with batch-based methods, and was robust to

  11. Robust Brain-Machine Interface Design Using Optimal Feedback Control Modeling and Adaptive Point Process Filtering.

    PubMed

    Shanechi, Maryam M; Orsborn, Amy L; Carmena, Jose M

    2016-04-01

    Much progress has been made in brain-machine interfaces (BMI) using decoders such as Kalman filters and finding their parameters with closed-loop decoder adaptation (CLDA). However, current decoders do not model the spikes directly, and hence may limit the processing time-scale of BMI control and adaptation. Moreover, while specialized CLDA techniques for intention estimation and assisted training exist, a unified and systematic CLDA framework that generalizes across different setups is lacking. Here we develop a novel closed-loop BMI training architecture that allows for processing, control, and adaptation using spike events, enables robust control and extends to various tasks. Moreover, we develop a unified control-theoretic CLDA framework within which intention estimation, assisted training, and adaptation are performed. The architecture incorporates an infinite-horizon optimal feedback-control (OFC) model of the brain's behavior in closed-loop BMI control, and a point process model of spikes. The OFC model infers the user's motor intention during CLDA-a process termed intention estimation. OFC is also used to design an autonomous and dynamic assisted training technique. The point process model allows for neural processing, control and decoder adaptation with every spike event and at a faster time-scale than current decoders; it also enables dynamic spike-event-based parameter adaptation unlike current CLDA methods that use batch-based adaptation on much slower adaptation time-scales. We conducted closed-loop experiments in a non-human primate over tens of days to dissociate the effects of these novel CLDA components. The OFC intention estimation improved BMI performance compared with current intention estimation techniques. OFC assisted training allowed the subject to consistently achieve proficient control. Spike-event-based adaptation resulted in faster and more consistent performance convergence compared with batch-based methods, and was robust to parameter

  12. RARtool: A MATLAB Software Package for Designing Response-Adaptive Randomized Clinical Trials with Time-to-Event Outcomes

    PubMed Central

    Ryeznik, Yevgen; Sverdlov, Oleksandr; Wong, Weng Kee

    2016-01-01

    Response-adaptive randomization designs are becoming increasingly popular in clinical trial practice. In this paper, we present RARtool, a user interface software developed in MATLAB for designing response-adaptive randomized comparative clinical trials with censored time-to-event outcomes. The RARtool software can compute different types of optimal treatment allocation designs, and it can simulate response-adaptive randomization procedures targeting selected optimal allocations. Through simulations, an investigator can assess design characteristics under a variety of experimental scenarios and select the best procedure for practical implementation. We illustrate the utility of our RARtool software by redesigning a survival trial from the literature. PMID:26997924

  13. Bayesian adaptive designs in single ascending dose trials in healthy volunteers

    PubMed Central

    Guédé, David; Reigner, Bruno; Vandenhende, Francois; Derks, Mike; Beyer, Ulrich; Jordan, Paul; Worth, Eric; Diack, Cheikh; Frey, Nicolas; Peck, Richard

    2014-01-01

    Aim Recent publications indicate a strong interest in applying Bayesian adaptive designs in first time in humans (FTIH) studies outside of oncology. The objective of the present work was to assess the performance of a new approach that includes Bayesian adaptive design in single ascending dose (SAD) trials conducted in healthy volunteers, in comparison with a more traditional approach. Methods A trial simulation approach was used and seven different scenarios of dose–response were tested. Results The new approach provided less biased estimates of maximum tolerated dose (MTD). In all scenarios, the number of subjects needed to define a MTD was lower with the new approach than with the traditional approach. With respect to duration of the trials, the two approaches were comparable. In all scenarios, the number of subjects exposed to a dose greater than the actual MTD was lower with the new approach than with the traditional approach. Conclusions The new approach with Bayesian adaptive design shows a very good performance in the estimation of MTD and in reducing the total number of healthy subjects. It also reduces the number of subjects exposed to doses greater than the actual MTD. PMID:24528176

  14. 3D design and electric simulation of a silicon drift detector using a spiral biasing adapter

    NASA Astrophysics Data System (ADS)

    Li, Yu-yun; Xiong, Bo; Li, Zheng

    2016-09-01

    The detector system of combining a spiral biasing adapter (SBA) with a silicon drift detector (SBA-SDD) is largely different from the traditional silicon drift detector (SDD), including the spiral SDD. It has a spiral biasing adapter of the same design as a traditional spiral SDD and an SDD with concentric rings having the same radius. Compared with the traditional spiral SDD, the SBA-SDD separates the spiral's functions of biasing adapter and the p-n junction definition. In this paper, the SBA-SDD is simulated using a Sentaurus TCAD tool, which is a full 3D device simulation tool. The simulated electric characteristics include electric potential, electric field, electron concentration, and single event effect. Because of the special design of the SBA-SDD, the SBA can generate an optimum drift electric field in the SDD, comparable with the conventional spiral SDD, while the SDD can be designed with concentric rings to reduce surface area. Also the current and heat generated in the SBA are separated from the SDD. To study the single event response, we simulated the induced current caused by incident heavy ions (20 and 50 μm penetration length) with different linear energy transfer (LET). The SBA-SDD can be used just like a conventional SDD, such as X-ray detector for energy spectroscopy and imaging, etc.

  15. Cascade direct adaptive fuzzy control design for a nonlinear two-axis inverted-pendulum servomechanism.

    PubMed

    Wai, Rong-Jong; Kuo, Meng-An; Lee, Jeng-Dao

    2008-04-01

    This paper presents and analyzes a cascade direct adaptive fuzzy control (DAFC) scheme for a two-axis inverted-pendulum servomechanism. Because the dynamic characteristic of the two-axis inverted-pendulum servomechanism is a nonlinear unstable nonminimum-phase underactuated system, it is difficult to design a suitable control scheme that simultaneously realizes real-time stabilization and accurate tracking control, and it is not easy to directly apply conventional computed torque strategies to this underactuated system. Therefore, the cascade DAFC scheme including inner and outer control loops is investigated for the stabilizing and tracking control of a nonlinear two-axis inverted-pendulum servomechanism. The goal of the inner control loop is to design a DAFC law so that the stick angle vector can fit the stick angle command vector derived from the stick angle reference model. In the outer loop, the reference signal vector is designed via an adaptive path planner so that the cart position vector tracks the cart position command vector. Moreover, all adaptive algorithms in the cascade DAFC system are derived using the Lyapunov stability analysis, so that system stability can be guaranteed in the entire closed-loop system. Relying on this cascade structure, the stick angle and cart position tracking-error vectors will simultaneously converge to zero. Numerical simulations and experimental results are given to verify that the proposed cascade DAFC system can achieve favorable stabilizing and tracking performance and is robust with regard to system uncertainties.

  16. Designing and Adapting Tasks in Lesson Planning: A Critical Process of Lesson Study

    ERIC Educational Resources Information Center

    Fujii, Toshiakira

    2016-01-01

    There is no doubt that a lesson plan is a necessary product of Lesson Study. However, the collaborative work among teachers that goes into creating that lesson plan is largely under-appreciated by non-Japanese adopters of Lesson Study, possibly because the effort involved is invisible to outsiders, with our attention going to its most visible…

  17. A design space exploration for control of Critical Quality Attributes of mAb.

    PubMed

    Bhatia, Hemlata; Read, Erik; Agarabi, Cyrus; Brorson, Kurt; Lute, Scott; Yoon, Seongkyu

    2016-10-15

    A unique "design space (DSp) exploration strategy," defined as a function of four key scenarios, was successfully integrated and validated to enhance the DSp building exercise, by increasing the accuracy of analyses and interpretation of processed data. The four key scenarios, defining the strategy, were based on cumulative analyses of individual models developed for the Critical Quality Attributes (23 Glycan Profiles) considered for the study. The analyses of the CQA estimates and model performances were interpreted as (1) Inside Specification/Significant Model (2) Inside Specification/Non-significant Model (3) Outside Specification/Significant Model (4) Outside Specification/Non-significant Model. Each scenario was defined and illustrated through individual models of CQA aligning the description. The R(2), Q(2), Model Validity and Model Reproducibility estimates of G2, G2FaGbGN, G0 and G2FaG2, respectively, signified the four scenarios stated above. Through further optimizations, including the estimation of Edge of Failure and Set Point Analysis, wider and accurate DSps were created for each scenario, establishing critical functional relationship between Critical Process Parameters (CPPs) and Critical Quality Attributes (CQAs). A DSp provides the optimal region for systematic evaluation, mechanistic understanding and refining of a QbD approach. DSp exploration strategy will aid the critical process of consistently and reproducibly achieving predefined quality of a product throughout its lifecycle. PMID:27575657

  18. A design space exploration for control of Critical Quality Attributes of mAb.

    PubMed

    Bhatia, Hemlata; Read, Erik; Agarabi, Cyrus; Brorson, Kurt; Lute, Scott; Yoon, Seongkyu

    2016-10-15

    A unique "design space (DSp) exploration strategy," defined as a function of four key scenarios, was successfully integrated and validated to enhance the DSp building exercise, by increasing the accuracy of analyses and interpretation of processed data. The four key scenarios, defining the strategy, were based on cumulative analyses of individual models developed for the Critical Quality Attributes (23 Glycan Profiles) considered for the study. The analyses of the CQA estimates and model performances were interpreted as (1) Inside Specification/Significant Model (2) Inside Specification/Non-significant Model (3) Outside Specification/Significant Model (4) Outside Specification/Non-significant Model. Each scenario was defined and illustrated through individual models of CQA aligning the description. The R(2), Q(2), Model Validity and Model Reproducibility estimates of G2, G2FaGbGN, G0 and G2FaG2, respectively, signified the four scenarios stated above. Through further optimizations, including the estimation of Edge of Failure and Set Point Analysis, wider and accurate DSps were created for each scenario, establishing critical functional relationship between Critical Process Parameters (CPPs) and Critical Quality Attributes (CQAs). A DSp provides the optimal region for systematic evaluation, mechanistic understanding and refining of a QbD approach. DSp exploration strategy will aid the critical process of consistently and reproducibly achieving predefined quality of a product throughout its lifecycle.

  19. Biostatistical methods for demonstrating efficacy in the regulatory setting. An epistemological approach to adaptive designs.

    PubMed

    Koch, A

    2005-05-01

    Adaptive designs are one of the most promising developments in statistics with applications to clinical trials. Obviously the knowledge at the beginning of a clinical trial will always be limited. In consequence it may be considered necessary that the knowledge from accumulating information should be used to optimize the design of the trial. This paper discusses conditions under which this may be possible in phase III clinical trials where the principle aim is confirmation of hypotheses that have been developed in earlier stages of drug development.

  20. Adaptive randomized algorithms for analysis and design of control systems under uncertain environments

    NASA Astrophysics Data System (ADS)

    Chen, Xinjia

    2015-05-01

    We consider the general problem of analysis and design of control systems in the presence of uncertainties. We treat uncertainties that affect a control system as random variables. The performance of the system is measured by the expectation of some derived random variables, which are typically bounded. We develop adaptive sequential randomized algorithms for estimating and optimizing the expectation of such bounded random variables with guaranteed accuracy and confidence level. These algorithms can be applied to overcome the conservatism and computational complexity in the analysis and design of controllers to be used in uncertain environments. We develop methods for investigating the optimality and computational complexity of such algorithms.

  1. Object-oriented software design for the Mt. Wilson 100-inch Hooker telescope adaptive optics system

    NASA Astrophysics Data System (ADS)

    Schneider, Thomas G.

    2000-06-01

    The object oriented software design paradigm has been instrumented in the development of the Adoptics software used in the Hooker telescope's ADOPT adaptive optics system. The software runs on a Pentium-class PC host and eight DSP processors connected to the host's motherboard bus. C++ classes were created to implement most of the host software's functionality, with the object oriented features of inheritance, encapsulation and abstraction being the most useful. Careful class design at the inception of the project allowed for the rapid addition of features without comprising the integrity of the software. Base class implementations include the DSP system, real-time graphical displays and opto-mechanical actuator control.

  2. The critical role of aerodynamic heating effects in the design of hypersonic vehicles

    NASA Technical Reports Server (NTRS)

    Wieting, Allan R.

    1989-01-01

    Hypersonic vehicles operate in a hostile aerothermal environment, which has a significant impact on their aerothermostructural performance. Significant coupling occurs between the aerodynamic flow field, structural heat transfer, and structural response, creating a multidisciplinary interaction. The critical role of aerodynamic heating effects in the design of hypersonic vehicles is identified with an example of high localized heating on an engine-cowl leading edge. Recent advances is integrated fluid-thermal-structural finite-element analyses are presented.

  3. A design and critical technology issues for on-orbit resupply of superfluid helium

    NASA Technical Reports Server (NTRS)

    Hopkins, Richard A.; Mord, Allan J.

    1990-01-01

    The issues of and the solutions to the critical design and technology areas of the Superfluid Helium On-Orbit Transfer (SHOOT) experiment, presently under development at the NASA Goddard Spaceflight Center, are discussed. Special attention is given to the SHOOT design requirements for the 10,000-liter superfluid He resupply tanker system, the concept details of the system, and the resupply operations and their analysis. A block diagram of the SHOOT system is included along with fluid management schematic and configuration diagrams of the system and its subsystems. A summary of the dewar performance is also presented.

  4. Spatial Designation of Critical Habitats for Endangered and Threatened Species in the United States

    SciTech Connect

    Tuttle, Mark A; Singh, Nagendra; Sabesan, Aarthy

    2008-01-01

    Establishing biological reserves or "hot spots" for endangered and threatened species is critical to support real-world species regulatory and management problems. Geographic data on the distribution of endangered and threatened species can be used to improve ongoing efforts for species conservation in the United States. At present no spatial database exists which maps out the location endangered species for the US. However, spatial descriptions do exists for the habitat associated with all endangered species, but in a form not readily suitable to use in a geographic information system (GIS). In our study, the principal challenge was extracting spatial data describing these critical habitats for 472 species from over 1000 pages of the federal register. In addition, an appropriate database schema was designed to accommodate the different tiers of information associated with the species along with the confidence of designation; the interpreted location data was geo-referenced to the county enumeration unit producing a spatial database of endangered species for the whole of US. The significance of these critical habitat designations, database scheme and methodologies will be discussed.

  5. Object-oriented philosophy in designing adaptive finite-element package for 3D elliptic deferential equations

    NASA Astrophysics Data System (ADS)

    Zhengyong, R.; Jingtian, T.; Changsheng, L.; Xiao, X.

    2007-12-01

    Although adaptive finite-element (AFE) analysis is becoming more and more focused in scientific and engineering fields, its efficient implementations are remain to be a discussed problem as its more complex procedures. In this paper, we propose a clear C++ framework implementation to show the powerful properties of Object-oriented philosophy (OOP) in designing such complex adaptive procedure. In terms of the modal functions of OOP language, the whole adaptive system is divided into several separate parts such as the mesh generation or refinement, a-posterior error estimator, adaptive strategy and the final post processing. After proper designs are locally performed on these separate modals, a connected framework of adaptive procedure is formed finally. Based on the general elliptic deferential equation, little efforts should be added in the adaptive framework to do practical simulations. To show the preferable properties of OOP adaptive designing, two numerical examples are tested. The first one is the 3D direct current resistivity problem in which the powerful framework is efficiently shown as only little divisions are added. And then, in the second induced polarization£¨IP£©exploration case, new adaptive procedure is easily added which adequately shows the strong extendibility and re-usage of OOP language. Finally we believe based on the modal framework adaptive implementation by OOP methodology, more advanced adaptive analysis system will be available in future.

  6. What do we mean by Human-Centered Design of Life-Critical Systems?

    PubMed

    Boy, Guy A

    2012-01-01

    Human-centered design is not a new approach to design. Aerospace is a good example of a life-critical systems domain where participatory design was fully integrated, involving experimental test pilots and design engineers as well as many other actors of the aerospace engineering community. This paper provides six topics that are currently part of the requirements of the Ph.D. Program in Human-Centered Design of the Florida Institute of Technology (FIT.) This Human-Centered Design program offers principles, methods and tools that support human-centered sustainable products such as mission or process control environments, cockpits and hospital operating rooms. It supports education and training of design thinkers who are natural leaders, and understand complex relationships among technology, organizations and people. We all need to understand what we want to do with technology, how we should organize ourselves to a better life and finally find out whom we are and have become. Human-centered design is being developed for all these reasons and issues.

  7. Design of adaptive fuzzy wavelet neural sliding mode controller for uncertain nonlinear systems.

    PubMed

    Shahriari kahkeshi, Maryam; Sheikholeslam, Farid; Zekri, Maryam

    2013-05-01

    This paper proposes novel adaptive fuzzy wavelet neural sliding mode controller (AFWN-SMC) for a class of uncertain nonlinear systems. The main contribution of this paper is to design smooth sliding mode control (SMC) for a class of high-order nonlinear systems while the structure of the system is unknown and no prior knowledge about uncertainty is available. The proposed scheme composed of an Adaptive Fuzzy Wavelet Neural Controller (AFWNC) to construct equivalent control term and an Adaptive Proportional-Integral (A-PI) controller for implementing switching term to provide smooth control input. Asymptotical stability of the closed loop system is guaranteed, using the Lyapunov direct method. To show the efficiency of the proposed scheme, some numerical examples are provided. To validate the results obtained by proposed approach, some other methods are adopted from the literature and applied for comparison. Simulation results show superiority and capability of the proposed controller to improve the steady state performance and transient response specifications by using less numbers of fuzzy rules and on-line adaptive parameters in comparison to other methods. Furthermore, control effort has considerably decreased and chattering phenomenon has been completely removed.

  8. Critical Design Issues of Tokamak Cooling Water System of ITER's Fusion Reactor

    SciTech Connect

    Kim, Seokho H; Berry, Jan

    2011-01-01

    U.S. ITER is responsible for the design, engineering, and procurement of the Tokamak Cooling Water System (TCWS). The TCWS transfers heat generated in the Tokamak to cooling water during nominal pulsed operation 850 MW at up to 150 C and 4.2 MPa water pressure. This water contains radionuclides because impurities (e.g., tritium) diffuse from in-vessel components and the vacuum vessel by water baking at 200 240 C at up to 4.4MPa, and corrosion products become activated by neutron bombardment. The system is designated as safety important class (SIC) and will be fabricated to comply with the French Order concerning nuclear pressure equipment (December 2005) and the EU Pressure Equipment Directive using ASME Section VIII, Div 2 design codes. The complexity of the TCWS design and fabrication presents unique challenges. Conceptual design of this one-of-a-kind cooling system has been completed with several issues that need to be resolved to move to next stage of the design. Those issues include flow balancing between over hundreds of branch pipelines in parallel to supply cooling water to blankets, determination of optimum flow velocity while minimizing the potential for cavitation damage, design for freezing protection for cooling water flowing through cryostat (freezing) environment, requirements for high-energy piping design, and electromagnetic impact to piping and components. Although the TCWS consists of standard commercial components such as piping with valves and fittings, heat exchangers, and pumps, complex requirements present interesting design challenges. This paper presents a brief description of TCWS conceptual design and critical design issues that need to be resolved.

  9. A new adaptive videogame for training attention and executive functions: design principles and initial validation.

    PubMed

    Montani, Veronica; De Filippo De Grazia, Michele; Zorzi, Marco

    2014-01-01

    A growing body of evidence suggests that action videogames could enhance a variety of cognitive skills and more specifically attention skills. The aim of this study was to develop a novel adaptive videogame to support the rehabilitation of the most common consequences of traumatic brain injury (TBI), that is the impairment of attention and executive functions. TBI patients can be affected by psychomotor slowness and by difficulties in dealing with distraction, maintain a cognitive set for a long time, processing different simultaneously presented stimuli, and planning purposeful behavior. Accordingly, we designed a videogame that was specifically conceived to activate those functions. Playing involves visuospatial planning and selective attention, active maintenance of the cognitive set representing the goal, and error monitoring. Moreover, different game trials require to alternate between two tasks (i.e., task switching) or to perform the two tasks simultaneously (i.e., divided attention/dual-tasking). The videogame is controlled by a multidimensional adaptive algorithm that calibrates task difficulty on-line based on a model of user performance that is updated on a trial-by-trial basis. We report simulations of user performance designed to test the adaptive game as well as a validation study with healthy participants engaged in a training protocol. The results confirmed the involvement of the cognitive abilities that the game is supposed to enhance and suggested that training improved attentional control during play.

  10. Using adaptive genetic algorithms in the design of morphological filters in textural image processing

    NASA Astrophysics Data System (ADS)

    Li, Wei; Haese-Coat, Veronique; Ronsin, Joseph

    1996-03-01

    An adaptive GA scheme is adopted for the optimal morphological filter design problem. The adaptive crossover and mutation rate which make the GA avoid premature and at the same time assure convergence of the program are successfully used in optimal morphological filter design procedure. In the string coding step, each string (chromosome) is composed of a structuring element coding chain concatenated with a filter sequence coding chain. In decoding step, each string is divided into 3 chains which then are decoded respectively into one structuring element with a size inferior to 5 by 5 and two concatenating morphological filter operators. The fitness function in GA is based on the mean-square-error (MSE) criterion. In string selection step, a stochastic tournament procedure is used to replace the simple roulette wheel program in order to accelerate the convergence. The final convergence of our algorithm is reached by a two step converging strategy. In presented applications of noise removal from texture images, it is found that with the optimized morphological filter sequences, the obtained MSE values are smaller than those using corresponding non-adaptive morphological filters, and the optimized shapes and orientations of structuring elements take approximately the same shapes and orientations as those of the image textons.

  11. A new adaptive videogame for training attention and executive functions: design principles and initial validation

    PubMed Central

    Montani, Veronica; De Filippo De Grazia, Michele; Zorzi, Marco

    2014-01-01

    A growing body of evidence suggests that action videogames could enhance a variety of cognitive skills and more specifically attention skills. The aim of this study was to develop a novel adaptive videogame to support the rehabilitation of the most common consequences of traumatic brain injury (TBI), that is the impairment of attention and executive functions. TBI patients can be affected by psychomotor slowness and by difficulties in dealing with distraction, maintain a cognitive set for a long time, processing different simultaneously presented stimuli, and planning purposeful behavior. Accordingly, we designed a videogame that was specifically conceived to activate those functions. Playing involves visuospatial planning and selective attention, active maintenance of the cognitive set representing the goal, and error monitoring. Moreover, different game trials require to alternate between two tasks (i.e., task switching) or to perform the two tasks simultaneously (i.e., divided attention/dual-tasking). The videogame is controlled by a multidimensional adaptive algorithm that calibrates task difficulty on-line based on a model of user performance that is updated on a trial-by-trial basis. We report simulations of user performance designed to test the adaptive game as well as a validation study with healthy participants engaged in a training protocol. The results confirmed the involvement of the cognitive abilities that the game is supposed to enhance and suggested that training improved attentional control during play. PMID:24860529

  12. Critical reading and critical thinking--study design and methodology: a personal approach on how to read the clinical literature.

    PubMed

    Lipman, Timothy O

    2013-04-01

    The volume of medical literature grows exponentially. Yet we are faced with the necessity to make clinical decisions based on the availability and quality of scientific information. The general strength (reliability, robustness) of any interpretation that guides us in clinical decision making is dependent on how information was obtained. All information and medical studies and, consequently, all conclusions are not created equal. It is incumbent upon us to be able to assess the quality of the information that guides us in the care of our patients. Being able to assess medical literature critically requires use of critical reading and critical thinking skills. To achieve these skills, to be able to analyze medical literature critically, takes a combination of education and practice, practice, and more practice.

  13. Evaluation of critical materials in five additional advance design photovoltaic cells

    SciTech Connect

    Smith, S.A.; Watts, R.L.; Martin, P.; Gurwell, W.E.

    1981-02-01

    The objective of this study is to identify potential material supply constraints due to the large-scale deployment of five advanced photovoltaic (PV) cell designs, and to suggest strategies to reduce the impacts of these production capacity limitations and potential future material shortages. The Critical Materials Assessment Program (CMAP) screens the designs and their supply chains and identifies potential shortages which might preclude large-scale use of the technologies. The results of the screening of five advanced PV cell designs are presented: (1) indium phosphide/cadmium sulfide, (2) zinc phosphide, (3) cadmium telluride/cadmium sulfide, (4) copper indium selenium, and (5) cadmium selenide photoelectrochemical. Each of these five cells is screened individually assuming that they first come online in 1991, and that 25 Gwe of peak capacity is online by the year 2000. A second computer screening assumes that each cell first comes online in 1991 and that each cell has a 5 GWe of peak capacity by the year 2000, so that the total online capacity for the five cells is 25 GWe. Based on a review of the preliminary baseline screening results, suggestions were made for varying such parameters as the layer thickness, cell production processes, etc. The resulting PV cell characterizations were then screened again by the CMAP computer code. The CMAP methodology used to identify critical materials is described; and detailed characterizations of the advanced photovoltaic cell designs under investigation, descriptions of additional cell production processes, and the results are presented. (WHK)

  14. Thermal Analysis of Iodine Satellite (iSAT) from Preliminary Design Review (PDR) to Critical Design Review (CDR)

    NASA Technical Reports Server (NTRS)

    Mauro, Stephanie

    2016-01-01

    The Iodine Satellite (iSAT) is a 12U cubesat with a primary mission to demonstrate the iodine fueled Hall Effect Thruster (HET) propulsion system. The spacecraft (SC) will operate throughout a one year mission in an effort to mature the propulsion system for use in future applications. The benefit of the HET is that it uses a propellant, iodine, which is easy to store and provides a high thrust-to-mass ratio. This paper will describe the thermal analysis and design of the SC between Preliminary Design Review (PDR) and Critical Design Review (CDR). The design of the satellite has undergone many changes due to a variety of challenges, both before PDR and during the time period discussed in this paper. Thermal challenges associated with the system include a high power density, small amounts of available radiative surface area, localized temperature requirements of the propulsion components, and unknown orbital parameters. The thermal control system is implemented to maintain component temperatures within their respective operational limits throughout the mission, while also maintaining propulsion components at the high temperatures needed to allow gaseous iodine propellant to flow. The design includes heaters, insulation, radiators, coatings, and thermal straps. Currently, the maximum temperatures for several components are near to their maximum operation limit, and the battery is close to its minimum operation limit. Mitigation strategies and planned work to solve these challenges will be discussed.

  15. Designing Adaptive Low-Dissipative High Order Schemes for Long-Time Integrations. Chapter 1

    NASA Technical Reports Server (NTRS)

    Yee, Helen C.; Sjoegreen, B.; Mansour, Nagi N. (Technical Monitor)

    2001-01-01

    A general framework for the design of adaptive low-dissipative high order schemes is presented. It encompasses a rather complete treatment of the numerical approach based on four integrated design criteria: (1) For stability considerations, condition the governing equations before the application of the appropriate numerical scheme whenever it is possible; (2) For consistency, compatible schemes that possess stability properties, including physical and numerical boundary condition treatments, similar to those of the discrete analogue of the continuum are preferred; (3) For the minimization of numerical dissipation contamination, efficient and adaptive numerical dissipation control to further improve nonlinear stability and accuracy should be used; and (4) For practical considerations, the numerical approach should be efficient and applicable to general geometries, and an efficient and reliable dynamic grid adaptation should be used if necessary. These design criteria are, in general, very useful to a wide spectrum of flow simulations. However, the demand on the overall numerical approach for nonlinear stability and accuracy is much more stringent for long-time integration of complex multiscale viscous shock/shear/turbulence/acoustics interactions and numerical combustion. Robust classical numerical methods for less complex flow physics are not suitable or practical for such applications. The present approach is designed expressly to address such flow problems, especially unsteady flows. The minimization of employing very fine grids to overcome the production of spurious numerical solutions and/or instability due to under-resolved grids is also sought. The incremental studies to illustrate the performance of the approach are summarized. Extensive testing and full implementation of the approach is forthcoming. The results shown so far are very encouraging.

  16. A Unifying Framework for Adaptive Radar Detection in Homogeneous Plus Structured Interference— Part II: Detectors Design

    NASA Astrophysics Data System (ADS)

    Ciuonzo, Domenico; De Maio, Antonio; Orlando, Danilo

    2016-06-01

    This paper deals with the problem of adaptive multidimensional/multichannel signal detection in homogeneous Gaussian disturbance with unknown covariance matrix and structured (unknown) deterministic interference. The aforementioned problem extends the well-known Generalized Multivariate Analysis of Variance (GMANOVA) tackled in the open literature. In a companion paper, we have obtained the Maximal Invariant Statistic (MIS) for the problem under consideration, as an enabling tool for the design of suitable detectors which possess the Constant False-Alarm Rate (CFAR) property. Herein, we focus on the development of several theoretically-founded detectors for the problem under consideration. First, all the considered detectors are shown to be function of the MIS, thus proving their CFARness property. Secondly, coincidence or statistical equivalence among some of them in such a general signal model is proved. Thirdly, strong connections to well-known simpler scenarios found in adaptive detection literature are established. Finally, simulation results are provided for a comparison of the proposed receivers.

  17. Semiglobal ISpS disturbance attenuation with output tracking via direct adaptive design.

    PubMed

    Ge, Shuzhi Sam; Han, Thanh-Trung

    2007-07-01

    Direct adaptive partial state feedback control is presented to achieve semiglobally input-to-state practically stable (ISpS) disturbance attenuation with output tracking for a class of uncertain time-varying nonlinear systems in which the unmeasured dynamics do not possess a constant disturbance attenuation level (CDAL). Identifying a necessary condition for the existence of a CDAL, direct adaptive neural networks (NNs) control is developed, where the universal approximation property of NNs and the domination design are employed together to overcome the difficulties due to the lack of state information, unknown system nonlinearities, and unknown state-dependent disturbance attenuation gain. The proposed method is coherent in the sense that it is applicable to the case in which a CDAL exists.

  18. Design of sewage treatment system by applying fuzzy adaptive PID controller

    NASA Astrophysics Data System (ADS)

    Jin, Liang-Ping; Li, Hong-Chan

    2013-03-01

    In the sewage treatment system, the dissolved oxygen concentration control, due to its nonlinear, time-varying, large time delay and uncertainty, is difficult to establish the exact mathematical model. While the conventional PID controller only works with good linear not far from its operating point, it is difficult to realize the system control when the operating point far off. In order to solve the above problems, the paper proposed a method which combine fuzzy control with PID methods and designed a fuzzy adaptive PID controller based on S7-300 PLC .It employs fuzzy inference method to achieve the online tuning for PID parameters. The control algorithm by simulation and practical application show that the system has stronger robustness and better adaptability.

  19. Some Challenges in the Design of Human-Automation Interaction for Safety-Critical Systems

    NASA Technical Reports Server (NTRS)

    Feary, Michael S.; Roth, Emilie

    2014-01-01

    Increasing amounts of automation are being introduced to safety-critical domains. While the introduction of automation has led to an overall increase in reliability and improved safety, it has also introduced a class of failure modes, and new challenges in risk assessment for the new systems, particularly in the assessment of rare events resulting from complex inter-related factors. Designing successful human-automation systems is challenging, and the challenges go beyond good interface development (e.g., Roth, Malin, & Schreckenghost 1997; Christoffersen & Woods, 2002). Human-automation design is particularly challenging when the underlying automation technology generates behavior that is difficult for the user to anticipate or understand. These challenges have been recognized in several safety-critical domains, and have resulted in increased efforts to develop training, procedures, regulations and guidance material (CAST, 2008, IAEA, 2001, FAA, 2013, ICAO, 2012). This paper points to the continuing need for new methods to describe and characterize the operational environment within which new automation concepts are being presented. We will describe challenges to the successful development and evaluation of human-automation systems in safety-critical domains, and describe some approaches that could be used to address these challenges. We will draw from experience with the aviation, spaceflight and nuclear power domains.

  20. The Iodine Satellite (iSat) Project Development Towards Critical Design Review

    NASA Technical Reports Server (NTRS)

    Dankanich, John W.; Calvert, Derek; Kamhawi, Hani; Hickman, Tyler; Szabo, James; Byrne, Lawrence

    2015-01-01

    Despite the prevalence of small satellites in recent years, the systems flown to date have very limited propulsion capability. SmallSats are typically secondary payloads and have significant constraints for volume, mass, and power in addition to limitations on the use of hazardous propellants or stored energy. These constraints limit the options for SmallSat maneuverability. NASA's Space Technology Mission Directorate approved the iodine Satellite flight project for a rapid demonstration of iodine Hall thruster technology in a 12U (cubesat units) configuration under the Small Spacecraft Technology Program. The mission is a partnership between NASA MSFC, NASA GRC, and Busek Co, Inc., with the Air Force supporting the propulsion technology maturation. The team is working towards the critical design review in the final design and fabrication phase of the project. The current design shows positive technical performance margins in all areas. The iSat project is planned for launch readiness in the spring of 2017.

  1. Covariance Matrix Adapted Evolution Strategy Based Design of Mixed H2/H ∞ PID Controller

    NASA Astrophysics Data System (ADS)

    Willjuice Iruthayarajan, M.; Baskar, S.

    This paper discusses the application of the covariance matrix adapted evolution strategy (CMAES) technique to the design of the mixed H2/H ∞ PID controller. The optimal robust PID controller is designed by minimizing the weighted sum of integral squared error (ISE) and balanced robust performance criterion involving robust stability and disturbance attenuation performance subjected to robust stability and disturbance attenuation constraints. In CMAES algorithm, these constraints are effectively handled by penalty parameter-less scheme. In order to test the performance of CMAES algorithm, MIMO distillation column model is considered. For the purpose of comparison, reported intelligent genetic algorithm (IGA) method is used. The statistical performances of combined ISE and balanced robust performance criterion in ten independent simulation runs show that a performance of CMAES is better than IGA method. Robustness test conducted on the system also shows that the robust performance of CMAES designed controller is better than IGA based controller under model uncertainty and external disturbances.

  2. Economic analysis of critical habitat designation for the desert tortoise (Mojave population)

    USGS Publications Warehouse

    Schamberger, Mel; MacGillvray, Timothy J.; Draper, Dirk D.

    1993-01-01

    The U.S. Fish and Wildlife Service emergency 1isted the Mojave population of the desert tortoise as endangered on August 4, 1989. The Mojave population formally was listed as threatened on April 2, 1990. The Endangered Species Act of 1973, as amended, requires that the economic benefits and costs and other relevant effects of critical habitat designation be considered. The Secretary of the Interior may exclude from designation areas where the costs of designation are greater than the benefits, unless the exclusion would result in extinction of the species. Desert tortoises are threatened by an accumulation of human-and disease-related mortality accompanied by habitat destruction, degradation, and fragmentation. Many desert tortoises are illegally collected for pets, food, and commercial trade. Others are accidentally struck and killed by vehicles on roads and highways or are killed by gunshot or vehicles traveling off-highway. Raven predation on hatchling desert tortoises has increased as raven populations in the desert have risen. An upper respiratory tract disease is suspected to be a major cause of mortality in the western Mojave Desert. This presumably incurable affliction presumably is thought to be spread through the release of infected tortoises into the desert. The Service has proposed designating critical habitat in nine counties within four states. The 12 critical habitat units encompass 6.4 million acres of land, more than 80% federally owned. This region is economically and demographically diverse. Most of the land is sparsely settled and characterized as a hot desert ecosystem. Major industries in the region include entertainment and lodging (primarily in Las Vegas), property development to accommodate the rapid population growth, and services. Millions of rural acres in the region are leased by the federal government for livestock grazing and used for mining. Overall economic benefits to the affected states derived from cattle and sheep grazing in the

  3. Critical to quality in telemedicine service management: application of DFSS (Design for Six Sigma) and SERVQUAL).

    PubMed

    Yun, Eun Kyoung; Chun, Kee Moon

    2008-01-01

    Telemedicine generally refers to the use of communications and information technologies for the delivery of health care. owever, telemedicine is not merely a simple combination of health care and technology. The researchers propose a systematic approach for assessing needs of telemedicine customers, called critical-to-quality (CTQ) in Six Sigma, with a purpose of continuous quality improvement. The combination approach using DFSS (Design for Six Sigma) and SERVQUAL (Service Quality Framework) was applied to define the critical quality attributes of telemedicine service management and to match them with the current telemedicine process. With a step-by-step procedure, telemedicine service process was reviewed and all the important CTQ candidates identified via a case study. The findings suggest that nurses need further understanding and research methods that will improve and manage the quality of health care service in various medical fields. PMID:19330973

  4. Critical to quality in telemedicine service management: application of DFSS (Design for Six Sigma) and SERVQUAL).

    PubMed

    Yun, Eun Kyoung; Chun, Kee Moon

    2008-01-01

    Telemedicine generally refers to the use of communications and information technologies for the delivery of health care. owever, telemedicine is not merely a simple combination of health care and technology. The researchers propose a systematic approach for assessing needs of telemedicine customers, called critical-to-quality (CTQ) in Six Sigma, with a purpose of continuous quality improvement. The combination approach using DFSS (Design for Six Sigma) and SERVQUAL (Service Quality Framework) was applied to define the critical quality attributes of telemedicine service management and to match them with the current telemedicine process. With a step-by-step procedure, telemedicine service process was reviewed and all the important CTQ candidates identified via a case study. The findings suggest that nurses need further understanding and research methods that will improve and manage the quality of health care service in various medical fields.

  5. L∞-gain adaptive fuzzy fault accommodation control design for nonlinear time-delay systems.

    PubMed

    Wu, Huai-Ning; Qiang, Xiao-Hong; Guo, Lei

    2011-06-01

    In this paper, an adaptive fuzzy fault accommodation (FA) control design with a guaranteed L(∞)-gain performance is developed for a class of nonlinear time-delay systems with persistent bounded disturbances. Using the Lyapunov technique and the Razumikhin-type lemma, the existence condition of the L(∞) -gain adaptive fuzzy FA controllers is provided in terms of linear matrix inequalities (LMIs). In the proposed FA scheme, a fuzzy logic system is employed to approximate the unknown term in the derivative of the Lyapunov function due to the unknown fault function; a continuous-state feedback control strategy is adopted for the control design to avoid the undesirable chattering phenomenon. The resulting FA controllers can ensure that every response of the closed-loop system is uniformly ultimately bounded with a guaranteed L(∞)-gain performance in the presence of a fault. Moreover, by the existing LMI optimization technique, a suboptimal controller is obtained in the sense of minimizing an upper bound of the L(∞)-gain. Finally, the achieved simulation results on the FA control of a continuous stirred tank reactor (CSTR) show the effectiveness of the proposed design procedure.

  6. Formation tracker design of multiple mobile robots with wheel perturbations: adaptive output-feedback approach

    NASA Astrophysics Data System (ADS)

    Yoo, Sung Jin

    2016-11-01

    This paper presents a theoretical design approach for output-feedback formation tracking of multiple mobile robots under wheel perturbations. It is assumed that these perturbations are unknown and the linear and angular velocities of the robots are unmeasurable. First, adaptive state observers for estimating unmeasurable velocities of the robots are developed under the robots' kinematics and dynamics including wheel perturbation effects. Then, we derive a virtual-structure-based formation tracker scheme according to the observer dynamic surface design procedure. The main difficulty of the output-feedback control design is to manage the coupling problems between unmeasurable velocities and unknown wheel perturbation effects. These problems are avoided by using the adaptive technique and the function approximation property based on fuzzy logic systems. From the Lyapunov stability analysis, it is shown that point tracking errors of each robot and synchronisation errors for the desired formation converge to an adjustable neighbourhood of the origin, while all signals in the controlled closed-loop system are semiglobally uniformly ultimately bounded.

  7. Truncated adaptation design for decentralised neural dynamic surface control of interconnected nonlinear systems under input saturation

    NASA Astrophysics Data System (ADS)

    Gao, Shigen; Dong, Hairong; Lyu, Shihang; Ning, Bin

    2016-07-01

    This paper studies decentralised neural adaptive control of a class of interconnected nonlinear systems, each subsystem is in the presence of input saturation and external disturbance and has independent system order. Using a novel truncated adaptation design, dynamic surface control technique and minimal-learning-parameters algorithm, the proposed method circumvents the problems of 'explosion of complexity' and 'dimension curse' that exist in the traditional backstepping design. Comparing to the methodology that neural weights are online updated in the controllers, only one scalar needs to be updated in the controllers of each subsystem when dealing with unknown systematic dynamics. Radial basis function neural networks (NNs) are used in the online approximation of unknown systematic dynamics. It is proved using Lyapunov stability theory that all the signals in the closed-loop system are semi-globally uniformly ultimately bounded. The tracking errors of each subsystems, the amplitude of NN approximation residuals and external disturbances can be attenuated to arbitrarily small by tuning proper design parameters. Simulation results are given to demonstrate the effectiveness of the proposed method.

  8. Adaptive filter design based on the LMS algorithm for delay elimination in TCR/FC compensators.

    PubMed

    Hooshmand, Rahmat Allah; Torabian Esfahani, Mahdi

    2011-04-01

    Thyristor controlled reactor with fixed capacitor (TCR/FC) compensators have the capability of compensating reactive power and improving power quality phenomena. Delay in the response of such compensators degrades their performance. In this paper, a new method based on adaptive filters (AF) is proposed in order to eliminate delay and increase the response of the TCR compensator. The algorithm designed for the adaptive filters is performed based on the least mean square (LMS) algorithm. In this design, instead of fixed capacitors, band-pass LC filters are used. To evaluate the filter, a TCR/FC compensator was used for nonlinear and time varying loads of electric arc furnaces (EAFs). These loads caused occurrence of power quality phenomena in the supplying system, such as voltage fluctuation and flicker, odd and even harmonics and unbalancing in voltage and current. The above design was implemented in a realistic system model of a steel complex. The simulation results show that applying the proposed control in the TCR/FC compensator efficiently eliminated delay in the response and improved the performance of the compensator in the power system.

  9. Design of adaptive control systems by means of self-adjusting transversal filters

    NASA Technical Reports Server (NTRS)

    Merhav, S. J.

    1986-01-01

    The design of closed-loop adaptive control systems based on nonparametric identification was addressed. Implementation is by self-adjusting Least Mean Square (LMS) transversal filters. The design concept is Model Reference Adaptive Control (MRAC). Major issues are to preserve the linearity of the error equations of each LMS filter, and to prevent estimation bias that is due to process or measurement noise, thus providing necessary conditions for the convergence and stability of the control system. The controlled element is assumed to be asymptotically stable and minimum phase. Because of the nonparametric Finite Impulse Response (FIR) estimates provided by the LMS filters, a-priori information on the plant model is needed only in broad terms. Following a survey of control system configurations and filter design considerations, system implementation is shown here in Single Input Single Output (SISO) format which is readily extendable to multivariable forms. In extensive computer simulation studies the controlled element is represented by a second-order system with widely varying damping, natural frequency, and relative degree.

  10. Adaptive filter design based on the LMS algorithm for delay elimination in TCR/FC compensators.

    PubMed

    Hooshmand, Rahmat Allah; Torabian Esfahani, Mahdi

    2011-04-01

    Thyristor controlled reactor with fixed capacitor (TCR/FC) compensators have the capability of compensating reactive power and improving power quality phenomena. Delay in the response of such compensators degrades their performance. In this paper, a new method based on adaptive filters (AF) is proposed in order to eliminate delay and increase the response of the TCR compensator. The algorithm designed for the adaptive filters is performed based on the least mean square (LMS) algorithm. In this design, instead of fixed capacitors, band-pass LC filters are used. To evaluate the filter, a TCR/FC compensator was used for nonlinear and time varying loads of electric arc furnaces (EAFs). These loads caused occurrence of power quality phenomena in the supplying system, such as voltage fluctuation and flicker, odd and even harmonics and unbalancing in voltage and current. The above design was implemented in a realistic system model of a steel complex. The simulation results show that applying the proposed control in the TCR/FC compensator efficiently eliminated delay in the response and improved the performance of the compensator in the power system. PMID:21193194

  11. Towards a critical design of an operational ground segment for an Earth observation mission

    NASA Astrophysics Data System (ADS)

    Storch, Tobias; Habermeyer, Martin; Eberle, Sabrina; Mühle, Helmut; Müller, Rupert

    2013-01-01

    The ground segment for the future remote sensing mission Environmental Mapping and Analysis Program (EnMAP; www.enmap.org) is developed by the Earth Observation Center and the German Space Operations Center at the German Aerospace Center. The launch is scheduled for 2017. An operational satellite ground segment is a highly complex heterogeneous system which has to cope with different levels of criticality, novelty, specificity, and to be operated for many years. It consists of equipment, hard- and software as well as operators with their procedures. The strengths of the global coherence of the segment-wide approach bringing these aspects together is examined and not on the local details of segment-specific issues. However, the effects on two software-based elements of the ground segment are considered in more detail, namely the product library and the level 2geo processor. The development methodology and how the critical design of the complete ground segment finished its detailed design phase successfully was achieved is analyzed. As a measure of the maturity of the design, its stability across the project phases is proposed.

  12. Adaptive uniform grayscale coded aperture design for high dynamic range compressive spectral imaging

    NASA Astrophysics Data System (ADS)

    Diaz, Nelson; Rueda, Hoover; Arguello, Henry

    2016-05-01

    Imaging spectroscopy is an important area with many applications in surveillance, agriculture and medicine. The disadvantage of conventional spectroscopy techniques is that they collect the whole datacube. In contrast, compressive spectral imaging systems capture snapshot compressive projections, which are the input of reconstruction algorithms to yield the underlying datacube. Common compressive spectral imagers use coded apertures to perform the coded projections. The coded apertures are the key elements in these imagers since they define the sensing matrix of the system. The proper design of the coded aperture entries leads to a good quality in the reconstruction. In addition, the compressive measurements are prone to saturation due to the limited dynamic range of the sensor, hence the design of coded apertures must consider saturation. The saturation errors in compressive measurements are unbounded and compressive sensing recovery algorithms only provide solutions for bounded noise or bounded with high probability. In this paper it is proposed the design of uniform adaptive grayscale coded apertures (UAGCA) to improve the dynamic range of the estimated spectral images by reducing the saturation levels. The saturation is attenuated between snapshots using an adaptive filter which updates the entries of the grayscale coded aperture based on the previous snapshots. The coded apertures are optimized in terms of transmittance and number of grayscale levels. The advantage of the proposed method is the efficient use of the dynamic range of the image sensor. Extensive simulations show improvements in the image reconstruction of the proposed method compared with grayscale coded apertures (UGCA) and adaptive block-unblock coded apertures (ABCA) in up to 10 dB.

  13. Design of a Performance-Adaptive PID Control System Based on Modeling Performance Assessment

    NASA Astrophysics Data System (ADS)

    Yamamoto, Toru

    In industrial processes represented by petroleum and refinery processes, it is necessary to establish the performance-driven control strategy in order to improve the productivity, which the control performance is firstly evaluated, and the controller is reconstructed. This paper describes a design scheme of performance-adaptive PID controllers which are based on the above control mechanism. According to the proposed control scheme, the system identification works corresponding to the result of modeling performance assessment, and PID parameters are computed using the newly estimated system parameters. In calculating the PID parameters, the desired control performance is considered. The behaviour of the proposed control scheme is numerically examined in some simulation examples.

  14. Update on Optical Design of Adaptive Optics System at Lick Observatory

    SciTech Connect

    Bauman, B J; Gavel, D T; Waltjen, K E; Freeze, G J; Hurd, R L; Gates, E I; Max, C E; Olivier, S S; Pennington, D M

    2001-07-31

    In 1999, we presented our plan to upgrade the adaptive optics (AO) system on the Lick Observatory Shane telescope (3m) from a prototype instrument pressed into field service to a facility instrument. This paper updates the progress of that plan and details several important improvements in the alignment and calibration of the AO bench. The paper also includes a discussion of the problems seen in the original design of the tip/tilt (t/t) sensor used in laser guide star mode, and how these problems were corrected with excellent results.

  15. A QoS adaptive multimedia transport system: design, implementation and experiences

    NASA Astrophysics Data System (ADS)

    Campbell, Andrew; Coulson, Geoff

    1997-03-01

    The long awaited `new environment' of high speed broadband networks and multimedia applications is fast becoming a reality. However, few systems in existence today, whether they be large scale pilots or small scale test-beds in research laboratories, offer a fully integrated and flexible environment where multimedia applications can maximally exploit the quality of service (QoS) capabilities of supporting networks and end-systems. In this paper we describe the implementation of an adaptive transport system that incorporates a QoS oriented API and a range of mechanisms to assist applications in exploiting QoS and adapting to fluctuations in QoS. The system, which is an instantiation of the Lancaster QoS Architecture, is implemented in a multi ATM switch network environment with Linux based PC end systems and continuous media file servers. A performance evaluation of the system configured to support video-on-demand application scenario is presented and discussed. Emphasis is placed on novel features of the system and on their integration into a complete prototype. The most prominent novelty of our design is a `distributed QoS adaptation' scheme which allows applications to delegate to the system responsibility for augmenting and reducing the perceptual quality of video and audio flows when resource availability increases or decreases.

  16. Design of adaptive dead-time control circuit for resonant half-bridge driver

    NASA Astrophysics Data System (ADS)

    Shi, Ling-Feng; Liu, Fu-Bo; He, Hui-Sen; Mao, Xiang-Yu; Lai, Xin-Quan

    2013-10-01

    To decrease the switching loss and the dead-time effect of resonant half-bridge inverter, a novel adaptive dead-time control circuit of resonant half-bridge driver Integrated Circuit (IC) is presented. Without increasing the pin number of IC, this circuit takes a novel strategy to adaptively regulate dead time to a temperate range between high and low thresholds. The high and low thresholds are adaptive to the fall time of output signal in a half-bridge clock cycle. The IC of the designed circuit is suitable for high-voltage applications. The dead-time regulation range of this circuit achieves 0-3.5 µs. The range of temperate dead-time state is 300 ns. The failure signal of this circuit can protect the IC and peripheral power devices by regulating operation in three clock cycles. Both simulation and measurement of the proposed circuit in a half-bridge driver IC with an operating frequency at 50 kHz are presented based on the 0.5 µm 700 V BCD process. The results of simulation and measurement show that the presented circuits' performance is perfect.

  17. The results of the critical design of the mission instruments of GOSAT-2

    NASA Astrophysics Data System (ADS)

    Yajima, Yukie; Suto, Hiroshi; Yotsumoto, Kazuhiko; Miyakawa, Takehiro; Hashimoto, Makiko; Shiomi, Kei; Nakajima, Masakatsu; Hirabayashi, Takeshi

    2016-04-01

    The GOSAT-2 is the successor satellite to the GOSAT which is the satellite dedicated to the measurements of the greenhouse gases such as carbon dioxide and methane. GOSAT was launched in January of 2009 and has been operated for about seven years. The development of the GOSAT-2 has been continued for two years, and through the preliminary and critical design phase the detail of the design of the mission instruments were fixed as well as the bus system design. The mission instruments of the GOSAT-2 are TANSO-FTS-2 and TANSO-CAI-2. TANSO-FTS-2 is the Fourier Transform Spectrometer observing greenhouse gases such as Carbon Dioxide and Methane and TANSO-CAI-2 is the imager observing the aerosols and clouds to compensate the TANSO-FTS-2 data and to grasp the movements of the aerosols such as PM2.5. The mission instruments will adopt the same kinds of instruments as GOSAT. But some improvements will be carried. Based on the results of the preliminary design, the design had been refined in the critical design phase and the results of the design meets all of the requirements on the mission instruments derived from the mission requirements to understand CO2 and CH4 sources and sinks and carbon cycle precisely. To improve the measurement accuracy, the signal to noise ratio will be increased by the extension of the aperture size from 64mm to 73mm and cooling the after optics as well as the thermal detectors. And to increase the number of the useful data, GOSAT-2 will equip the function to avoid the clouds during the observation using the images obtained by the monitor camera in FTS. To observe the carbon monoxide, the 2.3μm observation channel will be added. This function will be realized by the extension of the 2.0μm observation band to 2.3μm. The pointing angle in the along track direction will be extend from 20 degrees of GOSAT to 40 degrees to expand the observation area over the ocean where the sun glint is observed. This will make it possible to increase the number

  18. A Return to Innovative Engineering Design, Critical Thinking and Systems Engineering

    NASA Technical Reports Server (NTRS)

    Camarda, Charles J.

    2007-01-01

    I believe we are facing a critical time where innovative engineering design is of paramount importance to the success of our aerospace industry. However, the very qualities and attributes necessary for enhancing, educating, and mentoring a creative spirit are in decline in important areas. The importance of creativity and innovation in this country was emphasized by a special edition of the Harvard Business Review OnPoint entitled: "The Creative Company" which compiled a series of past and present articles on the subject of creativity and innovation and stressed its importance to our national economy. There is also a recognition of a lack of engineering, critical thinking and problem-solving skills in our education systems and a trend toward trying to enhance those skills by developing K-12 educational programs such as Project Lead the Way, "Science for All Americans", Benchmarks 2061 , etc. In addition, with respect to spacecraft development, we have a growing need for young to mid-level engineers with appropriate experience and skills in spacecraft design, development, analysis, testing, and systems engineering. As the Director of Engineering at NASA's Johnson Space Center, I realized that sustaining engineering support of an operational human spacecraft such as the Space Shuttle is decidedly different than engineering design and development skills necessary for designing a new spacecraft such as the Crew Exploration Vehicle of the Constellation Program. We learned a very important lesson post Columbia in that the Space Shuttle is truly an experimental and not an operational vehicle and the strict adherence to developed rules and processes and chains of command of an inherently bureaucratic organizational structure will not protect us from a host of known unknowns let alone unknown unknowns. There are no strict rules, processes, or procedures for understanding anomalous results of an experiment, anomalies with an experimental spacecraft like Shuttle, or in the

  19. Continuum Fatigue Damage Modeling for Critical Design, Control, and Fault Prognosis

    NASA Technical Reports Server (NTRS)

    Lorenzo, Carl F.

    1996-01-01

    This paper develops a simplified continuum (continuous with respect to time, stress, etc.) fatigue damage model for use in critical design, Life Extending Control and fault prognosis. The work is based on the local strain cyclic damage modeling method. New nonlinear explicit equation forms of cyclic damage in terms of stress amplitude are derived to facilitate the continuum modelling. Stress based continuum models are derived. Extension to plastic strain-strain rate models is also presented. Progress toward a non-zero mean stress based is presented. Also new nonlinear explicit equation forms in terms of stress amplitude are derived for this case. Application of the various models to design, control, and fault prognosis is considered.

  20. Fault tree synthesis for software design analysis of PLC based safety-critical systems

    SciTech Connect

    Koo, S. R.; Cho, C. H.; Seong, P. H.

    2006-07-01

    As a software verification and validation should be performed for the development of PLC based safety-critical systems, a software safety analysis is also considered in line with entire software life cycle. In this paper, we propose a technique of software safety analysis in the design phase. Among various software hazard analysis techniques, fault tree analysis is most widely used for the safety analysis of nuclear power plant systems. Fault tree analysis also has the most intuitive notation and makes both qualitative and quantitative analyses possible. To analyze the design phase more effectively, we propose a technique of fault tree synthesis, along with a universal fault tree template for the architecture modules of nuclear software. Consequently, we can analyze the safety of software on the basis of fault tree synthesis. (authors)

  1. Orthopaedic Surgery Under National Health Reform: An Analysis of Power, Process, Adaptation, and Leadership: AOA Critical Issues.

    PubMed

    Callahan, Charles D; Adair, Daniel; Bozic, Kevin J; Manning, Blaine T; Saleh, Jamal K; Saleh, Khaled J

    2014-07-01

    Morrison argued that demography, economy, and technology drive the evolution of industries from a formative first-generation state ("First Curve") to a radically different way of doing things ("Second Curve") that is marked by new skills, strategies, and partners. The current health-reform movement in the United States reflects these three key evolutionary trends: surging medical needs of an aging population, dramatic expansion of Medicare spending, and care delivery systems optimized through powerful information technology. Successful transition from a formative first-generation state (First Curve) to a radically different way of doing things (Second Curve) will require new skills, strategies, and partners. In a new world that is value-driven, community-centric (versus hospital-centric), and prevention-focused, orthopaedic surgeons and health-care administrators must form new alliances to reduce the cost of care and improve durable outcomes for musculoskeletal problems. The greatest barrier to success in the Second Curve stems not from lack of empirical support for integrated models of care, but rather from resistance by those who would execute them. Porter's five forces of competitive strategy and the behavioral analysis of change provide insights into the predictable forms of resistance that undermine clinical and economic success in the new environment of care. This paper analyzes the components that will differentiate orthopaedic care provision for the Second Curve. It also provides recommendations for future-focused orthopaedic surgery and health-care administrative leaders to consider as they design newly adaptive, mutually reinforcing, and economically viable musculoskeletal care processes that drive the level of orthopaedic care that our nation deserves-at a cost that it can afford. PMID:24990985

  2. Orthopaedic Surgery Under National Health Reform: An Analysis of Power, Process, Adaptation, and Leadership: AOA Critical Issues.

    PubMed

    Callahan, Charles D; Adair, Daniel; Bozic, Kevin J; Manning, Blaine T; Saleh, Jamal K; Saleh, Khaled J

    2014-07-01

    Morrison argued that demography, economy, and technology drive the evolution of industries from a formative first-generation state ("First Curve") to a radically different way of doing things ("Second Curve") that is marked by new skills, strategies, and partners. The current health-reform movement in the United States reflects these three key evolutionary trends: surging medical needs of an aging population, dramatic expansion of Medicare spending, and care delivery systems optimized through powerful information technology. Successful transition from a formative first-generation state (First Curve) to a radically different way of doing things (Second Curve) will require new skills, strategies, and partners. In a new world that is value-driven, community-centric (versus hospital-centric), and prevention-focused, orthopaedic surgeons and health-care administrators must form new alliances to reduce the cost of care and improve durable outcomes for musculoskeletal problems. The greatest barrier to success in the Second Curve stems not from lack of empirical support for integrated models of care, but rather from resistance by those who would execute them. Porter's five forces of competitive strategy and the behavioral analysis of change provide insights into the predictable forms of resistance that undermine clinical and economic success in the new environment of care. This paper analyzes the components that will differentiate orthopaedic care provision for the Second Curve. It also provides recommendations for future-focused orthopaedic surgery and health-care administrative leaders to consider as they design newly adaptive, mutually reinforcing, and economically viable musculoskeletal care processes that drive the level of orthopaedic care that our nation deserves-at a cost that it can afford.

  3. Rational Design and Adaptive Management of Combination Therapies for Hepatitis C Virus Infection

    PubMed Central

    Ke, Ruian; Loverdo, Claude; Qi, Hangfei; Sun, Ren; Lloyd-Smith, James O.

    2015-01-01

    Recent discoveries of direct acting antivirals against Hepatitis C virus (HCV) have raised hopes of effective treatment via combination therapies. Yet rapid evolution and high diversity of HCV populations, combined with the reality of suboptimal treatment adherence, make drug resistance a clinical and public health concern. We develop a general model incorporating viral dynamics and pharmacokinetics/ pharmacodynamics to assess how suboptimal adherence affects resistance development and clinical outcomes. We derive design principles and adaptive treatment strategies, identifying a high-risk period when missing doses is particularly risky for de novo resistance, and quantifying the number of additional doses needed to compensate when doses are missed. Using data from large-scale resistance assays, we demonstrate that the risk of resistance can be reduced substantially by applying these principles to a combination therapy of daclatasvir and asunaprevir. By providing a mechanistic framework to link patient characteristics to the risk of resistance, these findings show the potential of rational treatment design. PMID:26125950

  4. Adaptive change in electrically stimulated muscle: a framework for the design of clinical protocols.

    PubMed

    Salmons, Stanley

    2009-12-01

    Adult mammalian skeletal muscles have a remarkable capacity for adapting to increased use. Although this behavior is familiar from the changes brought about by endurance exercise, it is seen to a much greater extent in the response to long-term neuromuscular stimulation. The associated phenomena include a markedly increased resistance to fatigue, and this is the key to several clinical applications. However, a more rational basis is needed for designing regimes of stimulation that are conducive to an optimal outcome. In this review I examine relevant factors, such as the amount, frequency, and duty cycle of stimulation, the influence of force generation, and the animal model. From these considerations a framework emerges for the design of protocols that yield an overall functional profile appropriate to the application. Three contrasting examples illustrate the issues that need to be addressed clinically. PMID:19902542

  5. Development and design of flexible Fowler flaps for an adaptive wing

    NASA Astrophysics Data System (ADS)

    Monner, Hans P.; Hanselka, Holger; Breitbach, Elmar J.

    1998-06-01

    Civil transport airplanes fly with fixed geometry wings optimized only for one design point described by altitude, Mach number and airplane weight. These parameters vary continuously during flight, to which means the wing geometry seldom is optimal. According to aerodynamic investigations a chordwide variation of the wing camber leads to improvements in operational flexibility, buffet boundaries and performance resulting in reduction of fuel consumption. A spanwise differential camber variation allows to gain control over spanwise lift distributions reducing wing root bending moments. This paper describes the design of flexible Fowler flaps for an adaptive wing to be used in civil transport aircraft that allows both a chordwise as well as spanwise differential camber variation during flight. Since both lower and upper skins are flexed by active ribs, the camber variation is achieved with a smooth contour and without any additional gaps.

  6. An optimal adaptive design to address local regulations in global clinical trials.

    PubMed

    Luo, Xiaolong; Shih, Weichung Joe; Ouyang, S Peter; Delap, Robert J

    2010-01-01

    After multi-regional clinical trials (MRCTs) have demonstrated overall significant effects, evaluation for a region-specific effect is often important. Recent guidance from regulatory authorities regarding evaluation for possible country-specific effects has led to research on statistical designs that incorporate such evaluations in MRCTs. These statistical designs are intended to use the MRCTs to address the requirements for global registration of a medicinal product. Adding a regional requirement could change the probability for declaring positive effect for the region when there is indeed no treatment difference as well as when there is in fact a true difference within the region. In this paper, we first quantify those probability structures based on the guidance issued by the Ministry of Health, Labour and Welfare (MHLW) of Japan. An adaptive design is proposed to consider those probabilities and to optimize the efficiency for regional objectives. This two-stage approach incorporates comprehensive global objectives into an integrated study design and may mitigate the need for a separate local bridging study. A procedure is used to optimize region-specific enrollment based on an objective function. The overall sample size requirement is assessed. We will use simulation analyses to illustrate the performance of the proposed study design. PMID:20872620

  7. Design of a Virtual Reality Based Adaptive Response Technology for Children With Autism

    PubMed Central

    Lahiri, Uttama; Bekele, Esubalew; Dohrmann, Elizabeth; Warren, Zachary; Sarkar, Nilanjan

    2013-01-01

    Children with autism spectrum disorder (ASD) demonstrate potent impairments in social communication skills including atypical viewing patterns during social interactions. Recently, several assistive technologies, particularly virtual reality (VR), have been investigated to address specific social deficits in this population. Some studies have coupled eye-gaze monitoring mechanisms to design intervention strategies. However, presently available systems are designed to primarily chain learning via aspects of one’s performance only which affords restricted range of individualization. The presented work seeks to bridge this gap by developing a novel VR-based interactive system with Gaze-sensitive adaptive response technology that can seamlessly integrate VR-based tasks with eye-tracking techniques to intelligently facilitate engagement in tasks relevant to advancing social communication skills. Specifically, such a system is capable of objectively identifying and quantifying one’s engagement level by measuring real-time viewing patterns, subtle changes in eye physiological responses, as well as performance metrics in order to adaptively respond in an individualized manner to foster improved social communication skills among the participants. The developed system was tested through a usability study with eight adolescents with ASD. The results indicate the potential of the system to promote improved social task performance along with socially-appropriate mechanisms during VR-based social conversation tasks. PMID:23033333

  8. Design of a virtual reality based adaptive response technology for children with autism.

    PubMed

    Lahiri, Uttama; Bekele, Esubalew; Dohrmann, Elizabeth; Warren, Zachary; Sarkar, Nilanjan

    2013-01-01

    Children with autism spectrum disorder (ASD) demonstrate potent impairments in social communication skills including atypical viewing patterns during social interactions. Recently, several assistive technologies, particularly virtual reality (VR), have been investigated to address specific social deficits in this population. Some studies have coupled eye-gaze monitoring mechanisms to design intervention strategies. However, presently available systems are designed to primarily chain learning via aspects of one's performance only which affords restricted range of individualization. The presented work seeks to bridge this gap by developing a novel VR-based interactive system with Gaze-sensitive adaptive response technology that can seamlessly integrate VR-based tasks with eye-tracking techniques to intelligently facilitate engagement in tasks relevant to advancing social communication skills. Specifically, such a system is capable of objectively identifying and quantifying one's engagement level by measuring real-time viewing patterns, subtle changes in eye physiological responses, as well as performance metrics in order to adaptively respond in an individualized manner to foster improved social communication skills among the participants. The developed system was tested through a usability study with eight adolescents with ASD. The results indicate the potential of the system to promote improved social task performance along with socially-appropriate mechanisms during VR-based social conversation tasks. PMID:23033333

  9. Design, Fabrication, and Testing of SMA Enabled Adaptive Chevrons for Jet Noise Reduction

    NASA Technical Reports Server (NTRS)

    Turner, Travis L.; Buehrle, Ralph D.; Cano, Roberto J.; Fleming, Gary A.

    2004-01-01

    This study presents the status and results from an effort to design, fabricate, and test an adaptive jet engine chevron concept based upon embedding shape memory alloy (SMA) actuators in a composite laminate, termed a SMA hybrid composite (SMAHC). The approach for fabricating the adaptive SMAHC chevrons involves embedding prestrained Nitinol actuators on one side of the mid-plane of the composite laminate such that thermal excitation generates a thermal moment and deflects the structure. A glass-epoxy pre-preg/Nitinol ribbon material system and a vacuum hot press consolidation approach are employed. A versatile test system for control and measurement of the chevron deflection performance is described. Projection moire interferometry (PMI) is used for global deformation measurement and infrared (IR) thermography is used for 2-D temperature measurement and feedback control. A recently commercialized constitutive model for SMA and SMAHC materials is used in the finite element code ABAQUS to perform nonlinear static analysis of the chevron prototypes. Excellent agreement is achieved between the predicted and measured chevron deflection performance, thereby validating the design tool. Although the performance results presented in this paper fall short of the requirement, the concept is proven and an approach for achieving the performance objectives is evident.

  10. Design of a knee joint mechanism that adapts to individual physiology.

    PubMed

    Jiun-Yih Kuan; Pasch, Kenneth A; Herr, Hugh M

    2014-01-01

    This paper describes the design of a new knee joint mechanism, called the Adaptive Coupling Joint (ACJ). The new mechanism has an adaptive trajectory of the center of rotations (COR) that automatically matches those of the attached biological joint. The detailed design is presented as well as characterization results of the ACJ. Conventional exoskeleton and assistive devices usually consider limb joints as a one to three degrees of freedom (DOFs) joint synthesized by multiple one-DOF hinge joints in a single plane. However, the biological joints are complex and usually rotate with respect to a changing COR. As a result, the mismatch between limb joint motion and mechanical interface motion can lead to forces that cause undesired ligament and muscle length changes and internal mechanical changes. These undesired changes contribute to discomfort, as well as to the slippage and sluggish interaction between humans and devices. It is shown that the ACJ can transmit planetary torques from either active or passive devices to the limbs without altering the normal biological joint motion. PMID:25570389

  11. Design of a knee joint mechanism that adapts to individual physiology.

    PubMed

    Jiun-Yih Kuan; Pasch, Kenneth A; Herr, Hugh M

    2014-01-01

    This paper describes the design of a new knee joint mechanism, called the Adaptive Coupling Joint (ACJ). The new mechanism has an adaptive trajectory of the center of rotations (COR) that automatically matches those of the attached biological joint. The detailed design is presented as well as characterization results of the ACJ. Conventional exoskeleton and assistive devices usually consider limb joints as a one to three degrees of freedom (DOFs) joint synthesized by multiple one-DOF hinge joints in a single plane. However, the biological joints are complex and usually rotate with respect to a changing COR. As a result, the mismatch between limb joint motion and mechanical interface motion can lead to forces that cause undesired ligament and muscle length changes and internal mechanical changes. These undesired changes contribute to discomfort, as well as to the slippage and sluggish interaction between humans and devices. It is shown that the ACJ can transmit planetary torques from either active or passive devices to the limbs without altering the normal biological joint motion.

  12. ASIC-based design of NMR system health monitor for mission/safety-critical applications.

    PubMed

    Balasubramanian, P

    2016-01-01

    N-modular redundancy (NMR) is a generic fault tolerance scheme that is widely used in safety-critical circuit/system designs to guarantee the correct operation with enhanced reliability. In passive NMR, at least a majority (N + 1)/2 out of N function modules is expected to operate correctly at any time, where N is odd. Apart from a conventional realization of the NMR system, it would be useful to provide a concurrent indication of the system's health so that an appropriate remedial action may be initiated depending upon an application's safety criticality. In this context, this article presents the novel design of a generic NMR system health monitor which features: (i) early fault warning logic, that is activated upon the production of a conflicting result by even one output of any arbitrary function module, and (ii) error signalling logic, which signals an error when the number of faulty function modules unfortunately attains a majority and the system outputs may no more be reliable. Two sample implementations of NMR systems viz. triple modular redundancy and quintuple modular redundancy with the proposed system health monitoring are presented in this work, with a 4-bit ALU used for the function modules. The simulations are performed using a 32/28 nm CMOS process technology. PMID:27330894

  13. The Classroom Adaptation Scale: A Behavior Rating Scale Designed to Screen Primary Grade Children for School Adaptation Problems.

    ERIC Educational Resources Information Center

    Virbickis, Joseph A.

    After a brief historical review of the background and research, the paper focuses on development of a teacher-administered behavior rating scale to screen for school adaptation problems on a large scale basis using as Ss 15 primary grade teachers and their ratings of 315 primary grade children (ages 6-to-10 years) in their classes. A 16-item…

  14. Parametric Optimization of Some Critical Operating System Functions--An Alternative Approach to the Study of Operating Systems Design

    ERIC Educational Resources Information Center

    Sobh, Tarek M.; Tibrewal, Abhilasha

    2006-01-01

    Operating systems theory primarily concentrates on the optimal use of computing resources. This paper presents an alternative approach to teaching and studying operating systems design and concepts by way of parametrically optimizing critical operating system functions. Detailed examples of two critical operating systems functions using the…

  15. 77 FR 4169 - Endangered and Threatened Species: Final Rule To Revise the Critical Habitat Designation for the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-26

    ... notification of the extension of the public comment period for an additional 45 days, (75 FR 7434, February 19... leatherback sea turtle was listed as endangered throughout its range on June 2, 1970 (35 FR 8491). Pursuant to... designated critical habitat for leatherbacks on September 26, 1978 (43 FR 43688). This critical habitat...

  16. 78 FR 40970 - Endangered and Threatened Wildlife and Plants; Designation of Critical Habitat for Six West Texas...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-09

    ... Federal Register a proposed critical habitat designation for these species (77 FR 49602). Section 4(b)(2..., 2012 (77 FR 49602), for a complete discussion of the previous Federal actions for these species. We proposed all six species be listed as endangered with critical habitat on August 16, 2012 (77 FR 49602)....

  17. An Adaptive Defect Weighted Sampling Algorithm to Design Pseudoknotted RNA Secondary Structures

    PubMed Central

    Zandi, Kasra; Butler, Gregory; Kharma, Nawwaf

    2016-01-01

    Computational design of RNA sequences that fold into targeted secondary structures has many applications in biomedicine, nanotechnology and synthetic biology. An RNA molecule is made of different types of secondary structure elements and an important RNA element named pseudoknot plays a key role in stabilizing the functional form of the molecule. However, due to the computational complexities associated with characterizing pseudoknotted RNA structures, most of the existing RNA sequence designer algorithms generally ignore this important structural element and therefore limit their applications. In this paper we present a new algorithm to design RNA sequences for pseudoknotted secondary structures. We use NUPACK as the folding algorithm to compute the equilibrium characteristics of the pseudoknotted RNAs, and describe a new adaptive defect weighted sampling algorithm named Enzymer to design low ensemble defect RNA sequences for targeted secondary structures including pseudoknots. We used a biological data set of 201 pseudoknotted structures from the Pseudobase library to benchmark the performance of our algorithm. We compared the quality characteristics of the RNA sequences we designed by Enzymer with the results obtained from the state of the art MODENA and antaRNA. Our results show our method succeeds more frequently than MODENA and antaRNA do, and generates sequences that have lower ensemble defect, lower probability defect and higher thermostability. Finally by using Enzymer and by constraining the design to a naturally occurring and highly conserved Hammerhead motif, we designed 8 sequences for a pseudoknotted cis-acting Hammerhead ribozyme. Enzymer is available for download at https://bitbucket.org/casraz/enzymer. PMID:27499762

  18. An Adaptive Defect Weighted Sampling Algorithm to Design Pseudoknotted RNA Secondary Structures.

    PubMed

    Zandi, Kasra; Butler, Gregory; Kharma, Nawwaf

    2016-01-01

    Computational design of RNA sequences that fold into targeted secondary structures has many applications in biomedicine, nanotechnology and synthetic biology. An RNA molecule is made of different types of secondary structure elements and an important RNA element named pseudoknot plays a key role in stabilizing the functional form of the molecule. However, due to the computational complexities associated with characterizing pseudoknotted RNA structures, most of the existing RNA sequence designer algorithms generally ignore this important structural element and therefore limit their applications. In this paper we present a new algorithm to design RNA sequences for pseudoknotted secondary structures. We use NUPACK as the folding algorithm to compute the equilibrium characteristics of the pseudoknotted RNAs, and describe a new adaptive defect weighted sampling algorithm named Enzymer to design low ensemble defect RNA sequences for targeted secondary structures including pseudoknots. We used a biological data set of 201 pseudoknotted structures from the Pseudobase library to benchmark the performance of our algorithm. We compared the quality characteristics of the RNA sequences we designed by Enzymer with the results obtained from the state of the art MODENA and antaRNA. Our results show our method succeeds more frequently than MODENA and antaRNA do, and generates sequences that have lower ensemble defect, lower probability defect and higher thermostability. Finally by using Enzymer and by constraining the design to a naturally occurring and highly conserved Hammerhead motif, we designed 8 sequences for a pseudoknotted cis-acting Hammerhead ribozyme. Enzymer is available for download at https://bitbucket.org/casraz/enzymer. PMID:27499762

  19. An Adaptive Defect Weighted Sampling Algorithm to Design Pseudoknotted RNA Secondary Structures.

    PubMed

    Zandi, Kasra; Butler, Gregory; Kharma, Nawwaf

    2016-01-01

    Computational design of RNA sequences that fold into targeted secondary structures has many applications in biomedicine, nanotechnology and synthetic biology. An RNA molecule is made of different types of secondary structure elements and an important RNA element named pseudoknot plays a key role in stabilizing the functional form of the molecule. However, due to the computational complexities associated with characterizing pseudoknotted RNA structures, most of the existing RNA sequence designer algorithms generally ignore this important structural element and therefore limit their applications. In this paper we present a new algorithm to design RNA sequences for pseudoknotted secondary structures. We use NUPACK as the folding algorithm to compute the equilibrium characteristics of the pseudoknotted RNAs, and describe a new adaptive defect weighted sampling algorithm named Enzymer to design low ensemble defect RNA sequences for targeted secondary structures including pseudoknots. We used a biological data set of 201 pseudoknotted structures from the Pseudobase library to benchmark the performance of our algorithm. We compared the quality characteristics of the RNA sequences we designed by Enzymer with the results obtained from the state of the art MODENA and antaRNA. Our results show our method succeeds more frequently than MODENA and antaRNA do, and generates sequences that have lower ensemble defect, lower probability defect and higher thermostability. Finally by using Enzymer and by constraining the design to a naturally occurring and highly conserved Hammerhead motif, we designed 8 sequences for a pseudoknotted cis-acting Hammerhead ribozyme. Enzymer is available for download at https://bitbucket.org/casraz/enzymer.

  20. Design and application of a new modular adapter for laser diffraction characterization of inhalation aerosols.

    PubMed

    de Boer, A H; Gjaltema, D; Hagedoorn, P; Schaller, M; Witt, W; Frijlink, H W

    2002-12-01

    An inhaler adapter has been designed for the characterization of the aerosol clouds from medical aerosol generators such as nebulizers, dry powder inhalers (dpis) and metered dose inhalers (mdis) with laser diffraction technology. The adapter has a pre-separator, for separation of large particles (i.e. carrier crystals) from the aerosol cloud before it is exposed to the laser beam. It also has a fine particle collector for measuring the emitted mass fraction of fines by chemical detection methods after laser diffraction sizing. The closed system enables flow control through the aerosol generators and all test conditions, including ambient temperature and relative humidity, are automatically recorded. Counter flows minimize particle deposition onto the two windows for the laser beam, which make successive measurements without cleaning of these windows possible. The adapter has successfully been tested for nebulizers, mdis and dpis. In a comparative study with ten nebulizers it was found that these devices differ considerably in droplet size (distribution) of the aerosol cloud for the same 10% aqueous tobramycin solution (volume median diameters ranging from 1.25 to 3.25 microm) when they are used under the conditions recommended by the manufacturers. The droplet size distribution generated by the Sidestream (with PortaNeb compressor) is very constant during nebulization until dry running of the device. Comparative testing of dpis containing spherical pellet type of formulations for the drug (e.g. the AstraZeneca Turbuhaler) with the adapter is fast and simple. But also formulations containing larger carrier material could successfully be measured. Disintegration efficiency of a test inhaler with carrier retainment (acting as a pre-separator) could be measured quite accurately both for a colistin sulfate formulation with 16.7% of a lactose fraction 106-150 microm and for a budesonide formulation with a carrier mixture of Pharmatose 325 and 150 M. Therefore, it is

  1. ASPEN: a multitransmitter, bidirectional fiber optic data bus designed for use in critical aircraft applications

    NASA Astrophysics Data System (ADS)

    Morrison, Brian D.; Robillard, Michael N.

    1996-10-01

    Raytheon Aircraft Company has developed an architecture and protocol for implementing aircraft and vehicle control systems, based on fiber optics and fault-tolerant distributed control concepts. The processor and protocol technology base are derived from commercial open-standard, high-volume products which when coupled with proven fault- tolerance techniques provide substantial cost reductions versus competing protocols. Products based upon this architecture are presently being certified for aircraft control applications in General Aviation, and are beginning to find applications in civil transport and military applications. The system uses an open architecture fiber optic based serial data network, known as the Adaptive Standard PredictivE Network. This paper provides a technical introduction to the ASPENTM data bus technology. ASPEN has been developed by Raytheon Aircraft for its aircraft applications, and is available for use by other members of the aircraft industry as a standard. Descriptions of the systems being developed which use ASPEN as a component, as well as the techniques used to achieve critical level development assurance, are outside the scope of this paper.

  2. Complex Adaptive Systems of Systems (CASoS) engineering and foundations for global design.

    SciTech Connect

    Brodsky, Nancy S.; Finley, Patrick D.; Beyeler, Walter Eugene; Brown, Theresa Jean; Linebarger, John Michael; Moore, Thomas W.; Glass, Robert John, Jr.; Maffitt, S. Louise; Mitchell, Michael David; Ames, Arlo Leroy

    2012-01-01

    Complex Adaptive Systems of Systems, or CASoS, are vastly complex ecological, sociological, economic and/or technical systems which must be recognized and reckoned with to design a secure future for the nation and the world. Design within CASoS requires the fostering of a new discipline, CASoS Engineering, and the building of capability to support it. Towards this primary objective, we created the Phoenix Pilot as a crucible from which systemization of the new discipline could emerge. Using a wide range of applications, Phoenix has begun building both theoretical foundations and capability for: the integration of Applications to continuously build common understanding and capability; a Framework for defining problems, designing and testing solutions, and actualizing these solutions within the CASoS of interest; and an engineering Environment required for 'the doing' of CASoS Engineering. In a secondary objective, we applied CASoS Engineering principles to begin to build a foundation for design in context of Global CASoS

  3. The optical design of a visible adaptive optics system for the Magellan Telescope

    NASA Astrophysics Data System (ADS)

    Kopon, Derek

    The Magellan Adaptive Optics system will achieve first light in November of 2012. This AO system contains several subsystems including the 585-actuator concave adaptive secondary mirror, the Calibration Return Optic (CRO) alignment and calibration system, the CLIO 1-5 microm IR science camera, the movable guider camera and active optics assembly, and the W-Unit, which contains both the Pyramid Wavefront Sensor (PWFS) and the VisAO visible science camera. In this dissertation, we present details of the design, fabrication, assembly, alignment, and laboratory performance of the VisAO camera and its optical components. Many of these components required a custom design, such as the Spectral Differential Imaging Wollaston prisms and filters and the coronagraphic spots. One component, the Atmospheric Dispersion Corrector (ADC), required a unique triplet design that had until now never been fabricated and tested on sky. We present the design, laboratory, and on-sky results for our triplet ADC. We also present details of the CRO test setup and alignment. Because Magellan is a Gregorian telescope, the ASM is a concave ellipsoidal mirror. By simulating a star with a white light point source at the far conjugate, we can create a double-pass test of the whole system without the need for a real on-sky star. This allows us to test the AO system closed loop in the Arcetri test tower at its nominal design focal length and optical conjugates. The CRO test will also allow us to calibrate and verify the system off-sky at the Magellan telescope during commissioning and periodically thereafter. We present a design for a possible future upgrade path for a new visible Integral Field Spectrograph. By integrating a fiber array bundle at the VisAO focal plane, we can send light to a pre-existing facility spectrograph, such as LDSS3, which will allow 20 mas spatial sampling and R˜1,800 spectra over the band 0.6-1.05 microm. This would be the highest spatial resolution IFU to date, either

  4. Dynamic modeling, property investigation, and adaptive controller design of serial robotic manipulators modeled with structural compliance

    NASA Technical Reports Server (NTRS)

    Tesar, Delbert; Tosunoglu, Sabri; Lin, Shyng-Her

    1990-01-01

    Research results on general serial robotic manipulators modeled with structural compliances are presented. Two compliant manipulator modeling approaches, distributed and lumped parameter models, are used in this study. System dynamic equations for both compliant models are derived by using the first and second order influence coefficients. Also, the properties of compliant manipulator system dynamics are investigated. One of the properties, which is defined as inaccessibility of vibratory modes, is shown to display a distinct character associated with compliant manipulators. This property indicates the impact of robot geometry on the control of structural oscillations. Example studies are provided to illustrate the physical interpretation of inaccessibility of vibratory modes. Two types of controllers are designed for compliant manipulators modeled by either lumped or distributed parameter techniques. In order to maintain the generality of the results, neither linearization is introduced. Example simulations are given to demonstrate the controller performance. The second type controller is also built for general serial robot arms and is adaptive in nature which can estimate uncertain payload parameters on-line and simultaneously maintain trajectory tracking properties. The relation between manipulator motion tracking capability and convergence of parameter estimation properties is discussed through example case studies. The effect of control input update delays on adaptive controller performance is also studied.

  5. Experimental evaluation of shape memory alloy actuation technique in adaptive antenna design concepts

    NASA Technical Reports Server (NTRS)

    Kefauver, W. Neill; Carpenter, Bernie F.

    1994-01-01

    Creation of an antenna system that could autonomously adapt contours of reflecting surfaces to compensate for structural loads induced by a variable environment would maximize performance of space-based communication systems. Design of such a system requires the comprehensive development and integration of advanced actuator, sensor, and control technologies. As an initial step in this process, a test has been performed to assess the use of a shape memory alloy as a potential actuation technique. For this test, an existing, offset, cassegrain antenna system was retrofit with a subreflector equipped with shape memory alloy actuators for surface contour control. The impacts that the actuators had on both the subreflector contour and the antenna system patterns were measured. The results of this study indicate the potential for using shape memory alloy actuation techniques to adaptively control antenna performance; both variations in gain and beam steering capabilities were demonstrated. Future development effort is required to evolve this potential into a useful technology for satellite applications.

  6. Design of Robust Adaptive Unbalance Response Controllers for Rotors with Magnetic Bearings

    NASA Technical Reports Server (NTRS)

    Knospe, Carl R.; Tamer, Samir M.; Fedigan, Stephen J.

    1996-01-01

    Experimental results have recently demonstrated that an adaptive open loop control strategy can be highly effective in the suppression of unbalance induced vibration on rotors supported in active magnetic bearings. This algorithm, however, relies upon a predetermined gain matrix. Typically, this matrix is determined by an optimal control formulation resulting in the choice of the pseudo-inverse of the nominal influence coefficient matrix as the gain matrix. This solution may result in problems with stability and performance robustness since the estimated influence coefficient matrix is not equal to the actual influence coefficient matrix. Recently, analysis tools have been developed to examine the robustness of this control algorithm with respect to structured uncertainty. Herein, these tools are extended to produce a design procedure for determining the adaptive law's gain matrix. The resulting control algorithm has a guaranteed convergence rate and steady state performance in spite of the uncertainty in the rotor system. Several examples are presented which demonstrate the effectiveness of this approach and its advantages over the standard optimal control formulation.

  7. Adaptation and focusing of optode configurations for fluorescence optical tomography by experimental design methods

    NASA Astrophysics Data System (ADS)

    Freiberger, Manuel; Clason, Christian; Scharfetter, Hermann

    2010-01-01

    Fluorescence tomography excites a fluorophore inside a sample by light sources on the surface. From boundary measurements of the fluorescent light, the distribution of the fluorophore is reconstructed. The optode placement determines the quality of the reconstructions in terms of, e.g., resolution and contrast-to-noise ratio. We address the adaptation of the measurement setup. The redundancy of the measurements is chosen as a quality criterion for the optodes and is computed from the Jacobian of the mathematical formulation of light propagation. The algorithm finds a subset with minimum redundancy in the measurements from a feasible pool of optodes. This allows biasing the design in order to favor reconstruction results inside a given region. Two different variations of the algorithm, based on geometric and arithmetic averaging, are compared. Both deliver similar optode configurations. The arithmetic averaging is slightly more stable, whereas the geometric averaging approach shows a better conditioning of the sensitivity matrix and mathematically corresponds more closely with entropy optimization. Adapted illumination and detector patterns are presented for an initial set of 96 optodes placed on a cylinder with focusing on different regions. Examples for the attenuation of fluorophore signals from regions outside the focus are given.

  8. The Iodine Satellite (iSat) Project Development Towards Critical Design Review (CDR)

    NASA Technical Reports Server (NTRS)

    Dankanich, John W.; Selby, Michael; Polzin, Kurt A.; Kamhawi, Hani; Hickman, Tyler; Byrne, Larry

    2016-01-01

    Despite the prevalence of Small Satellites in recent years, the systems flown to date have very limited propulsion capability. SmallSats are typically secondary payloads and have significant constraints for volume, mass, and power in addition to limitations on the use of hazardous propellants or stored energy (i.e. high pressure vessels). These constraints limit the options for SmallSat maneuverability. NASA's Space Technology Mission Directorate approved the iodine Satellite flight project for a rapid demonstration of iodine Hall thruster technology in a 12U configuration under the Small Spacecraft Technology Program. The project formally began in FY15 as a partnership between NASA MSFC, NASA GRC, and Busek Co, Inc., with the Air Force supporting the propulsion technology maturation. The team is in final preparation of the Critical Design Review prior to initiating the fabrication and integration phase of the project. The iSat project is on schedule for a launch opportunity in November 2017.

  9. An aspect-oriented approach for designing safety-critical systems

    NASA Astrophysics Data System (ADS)

    Petrov, Z.; Zaykov, P. G.; Cardoso, J. P.; Coutinho, J. G. F.; Diniz, P. C.; Luk, W.

    The development of avionics systems is typically a tedious and cumbersome process. In addition to the required functions, developers must consider various and often conflicting non-functional requirements such as safety, performance, and energy efficiency. Certainly, an integrated approach with a seamless design flow that is capable of requirements modelling and supporting refinement down to an actual implementation in a traceable way, may lead to a significant acceleration of development cycles. This paper presents an aspect-oriented approach supported by a tool chain that deals with functional and non-functional requirements in an integrated manner. It also discusses how the approach can be applied to development of safety-critical systems and provides experimental results.

  10. Microstructural modeling and design optimization of adaptive thin-film nanocomposite coatings for durability and wear

    NASA Astrophysics Data System (ADS)

    Pearson, James Deon

    Adaptive thin-film nanocomposite coatings comprised of crystalline ductile phases of gold and molybdenum disulfide, and brittle phases of diamond like carbon (DLC) and ytrria stabilized zirconia (YSZ) have been investigated by specialized microstructurally-based finite-element techniques. A new microstructural computational technique for efficiently creating models of nanocomposite coatings with control over composition, grain size, spacing and morphologies has been developed to account for length scales that range from nanometers to millimeters for efficient computations. The continuum mechanics model at the nanometer scale was verified with molecular dynamic models for nanocrystalline diamond. Using this new method, the interrelated effects of microstructural characteristics such as grain shapes and sizes, matrix thicknesses, local material behavior due to interfacial stresses and strains, varying amorphous and crystalline compositions, and transfer film adhesion and thickness on coating behavior have been investigated. A mechanistic model to account for experimentally observed transfer film adhesion modes and changes in thickness was also developed. One of the major objectives of this work is to determine optimal crystalline and amorphous compositions and behavior related to wear and durability over a wide range of thermo-mechanical conditions. The computational predictions, consistent with experimental observations, indicate specific interfacial regions between DLC and ductile metal inclusions are critical regions of stress and strain accumulation that can be precursors to material failure and wear. The predicted results underscore a competition between the effects of superior tribological properties associated with MoS 2 and maintaining manageable stress levels that would not exceed the coating strength. Varying the composition results in tradeoffs between lubrication, toughness, and strength, and the effects of critical stresses and strains can be controlled

  11. Integrated System Design: Promoting the Capacity of Sociotechnical Systems for Adaptation through Extensions of Cognitive Work Analysis.

    PubMed

    Naikar, Neelam; Elix, Ben

    2016-01-01

    This paper proposes an approach for integrated system design, which has the intent of facilitating high levels of effectiveness in sociotechnical systems by promoting their capacity for adaptation. Building on earlier ideas and empirical observations, this approach recognizes that to create adaptive systems it is necessary to integrate the design of all of the system elements, including the interfaces, teams, training, and automation, such that workers are supported in adapting their behavior as well as their structure, or organization, in a coherent manner. Current approaches for work analysis and design are limited in regard to this fundamental objective, especially in cases when workers are confronted with unforeseen events. A suitable starting point is offered by cognitive work analysis (CWA), but while this framework can support actors in adapting their behavior, it does not necessarily accommodate adaptations in their structure. Moreover, associated design approaches generally focus on individual system elements, and those that consider multiple elements appear limited in their ability to facilitate integration, especially in the manner intended here. The proposed approach puts forward the set of possibilities for work organization in a system as the central mechanism for binding the design of its various elements, so that actors can adapt their structure as well as their behavior-in a unified fashion-to handle both familiar and novel conditions. Accordingly, this paper demonstrates how the set of possibilities for work organization in a system may be demarcated independently of the situation, through extensions of CWA, and how it may be utilized in design. This lynchpin, conceptualized in the form of a diagram of work organization possibilities (WOP), is important for preserving a system's inherent capacity for adaptation. Future research should focus on validating these concepts and establishing the feasibility of implementing them in industrial contexts

  12. Integrated System Design: Promoting the Capacity of Sociotechnical Systems for Adaptation through Extensions of Cognitive Work Analysis

    PubMed Central

    Naikar, Neelam; Elix, Ben

    2016-01-01

    This paper proposes an approach for integrated system design, which has the intent of facilitating high levels of effectiveness in sociotechnical systems by promoting their capacity for adaptation. Building on earlier ideas and empirical observations, this approach recognizes that to create adaptive systems it is necessary to integrate the design of all of the system elements, including the interfaces, teams, training, and automation, such that workers are supported in adapting their behavior as well as their structure, or organization, in a coherent manner. Current approaches for work analysis and design are limited in regard to this fundamental objective, especially in cases when workers are confronted with unforeseen events. A suitable starting point is offered by cognitive work analysis (CWA), but while this framework can support actors in adapting their behavior, it does not necessarily accommodate adaptations in their structure. Moreover, associated design approaches generally focus on individual system elements, and those that consider multiple elements appear limited in their ability to facilitate integration, especially in the manner intended here. The proposed approach puts forward the set of possibilities for work organization in a system as the central mechanism for binding the design of its various elements, so that actors can adapt their structure as well as their behavior—in a unified fashion—to handle both familiar and novel conditions. Accordingly, this paper demonstrates how the set of possibilities for work organization in a system may be demarcated independently of the situation, through extensions of CWA, and how it may be utilized in design. This lynchpin, conceptualized in the form of a diagram of work organization possibilities (WOP), is important for preserving a system's inherent capacity for adaptation. Future research should focus on validating these concepts and establishing the feasibility of implementing them in industrial

  13. Integrated System Design: Promoting the Capacity of Sociotechnical Systems for Adaptation through Extensions of Cognitive Work Analysis.

    PubMed

    Naikar, Neelam; Elix, Ben

    2016-01-01

    This paper proposes an approach for integrated system design, which has the intent of facilitating high levels of effectiveness in sociotechnical systems by promoting their capacity for adaptation. Building on earlier ideas and empirical observations, this approach recognizes that to create adaptive systems it is necessary to integrate the design of all of the system elements, including the interfaces, teams, training, and automation, such that workers are supported in adapting their behavior as well as their structure, or organization, in a coherent manner. Current approaches for work analysis and design are limited in regard to this fundamental objective, especially in cases when workers are confronted with unforeseen events. A suitable starting point is offered by cognitive work analysis (CWA), but while this framework can support actors in adapting their behavior, it does not necessarily accommodate adaptations in their structure. Moreover, associated design approaches generally focus on individual system elements, and those that consider multiple elements appear limited in their ability to facilitate integration, especially in the manner intended here. The proposed approach puts forward the set of possibilities for work organization in a system as the central mechanism for binding the design of its various elements, so that actors can adapt their structure as well as their behavior-in a unified fashion-to handle both familiar and novel conditions. Accordingly, this paper demonstrates how the set of possibilities for work organization in a system may be demarcated independently of the situation, through extensions of CWA, and how it may be utilized in design. This lynchpin, conceptualized in the form of a diagram of work organization possibilities (WOP), is important for preserving a system's inherent capacity for adaptation. Future research should focus on validating these concepts and establishing the feasibility of implementing them in industrial contexts.

  14. Physical Constraints on Biological Integral Control Design for Homeostasis and Sensory Adaptation

    PubMed Central

    Ang, Jordan; McMillen, David R.

    2013-01-01

    Synthetic biology includes an effort to use design-based approaches to create novel controllers, biological systems aimed at regulating the output of other biological processes. The design of such controllers can be guided by results from control theory, including the strategy of integral feedback control, which is central to regulation, sensory adaptation, and long-term robustness. Realization of integral control in a synthetic network is an attractive prospect, but the nature of biochemical networks can make the implementation of even basic control structures challenging. Here we present a study of the general challenges and important constraints that will arise in efforts to engineer biological integral feedback controllers or to analyze existing natural systems. Constraints arise from the need to identify target output values that the combined process-plus-controller system can reach, and to ensure that the controller implements a good approximation of integral feedback control. These constraints depend on mild assumptions about the shape of input-output relationships in the biological components, and thus will apply to a variety of biochemical systems. We summarize our results as a set of variable constraints intended to provide guidance for the design or analysis of a working biological integral feedback controller. PMID:23442873

  15. Design of a shape adaptive airfoil actuated by a Shape Memory Alloy strip for airplane tail

    NASA Astrophysics Data System (ADS)

    Shirzadeh, R.; Raissi Charmacani, K.; Tabesh, M.

    2011-04-01

    Of the factors that mainly affect the efficiency of the wing during a special flow regime, the shape of its airfoil cross section is the most significant. Airfoils are generally designed for a specific flight condition and, therefore, are not fully optimized in all flight conditions. It is very desirable to have an airfoil with the ability to change its shape based on the current regime. Shape memory alloy (SMA) actuators activate in response to changes in the temperature and can recover their original configuration after being deformed. This study presents the development of a method to control the shape of an airfoil using SMA actuators. To predict the thermomechanical behaviors of an SMA thin strip, 3D incremental formulation of the SMA constitutive model is implemented in FEA software package ABAQUS. The interactions between the airfoil structure and SMA thin strip actuator are investigated. Also, the aerodynamic performance of a standard airfoil with a plain flap is compared with an adaptive airfoil.

  16. CONFIG - Adapting qualitative modeling and discrete event simulation for design of fault management systems

    NASA Technical Reports Server (NTRS)

    Malin, Jane T.; Basham, Bryan D.

    1989-01-01

    CONFIG is a modeling and simulation tool prototype for analyzing the normal and faulty qualitative behaviors of engineered systems. Qualitative modeling and discrete-event simulation have been adapted and integrated, to support early development, during system design, of software and procedures for management of failures, especially in diagnostic expert systems. Qualitative component models are defined in terms of normal and faulty modes and processes, which are defined by invocation statements and effect statements with time delays. System models are constructed graphically by using instances of components and relations from object-oriented hierarchical model libraries. Extension and reuse of CONFIG models and analysis capabilities in hybrid rule- and model-based expert fault-management support systems are discussed.

  17. Adaptive silicon monochromators for high-power wigglers; design, finite-element analysis and laboratory tests.

    PubMed

    Quintana, J P; Hart, M

    1995-05-01

    Multipole wigglers in storage rings already produce X-ray power in the range up to a few kilowatts and planned devices at third-generation facilities promise up to 30 kW. Although the power density at the monochromator position is an order of magnitude lower than that from undulators, the thermal strain field in the beam footprint can still cause severe loss of performance in X-ray optical systems. For an optimized adaptive design, the results of finite-element analysis are compared with double-crystal rocking curves obtained with a laboratory X-ray source and, in a second paper [Quintana, Hart, Bilderback, Henderson, Richter, Setterson, White, Hausermann, Krumrey & Schulte-Schrepping (1995). J. Synchotron Rad. 2, 1-5], successful tests at wiggler sources at CHESS and ESRF and in an undulator source at HASYLAB are reported.

  18. Adapting Rational Unified Process (RUP) approach in designing a secure e-Tendering model

    NASA Astrophysics Data System (ADS)

    Mohd, Haslina; Robie, Muhammad Afdhal Muhammad; Baharom, Fauziah; Darus, Norida Muhd; Saip, Mohamed Ali; Yasin, Azman

    2016-08-01

    e-Tendering is an electronic processing of the tender document via internet and allow tenderer to publish, communicate, access, receive and submit all tender related information and documentation via internet. This study aims to design the e-Tendering system using Rational Unified Process approach. RUP provides a disciplined approach on how to assign tasks and responsibilities within the software development process. RUP has four phases that can assist researchers to adjust the requirements of various projects with different scope, problem and the size of projects. RUP is characterized as a use case driven, architecture centered, iterative and incremental process model. However the scope of this study only focusing on Inception and Elaboration phases as step to develop the model and perform only three of nine workflows (business modeling, requirements, analysis and design). RUP has a strong focus on documents and the activities in the inception and elaboration phases mainly concern the creation of diagrams and writing of textual descriptions. The UML notation and the software program, Star UML are used to support the design of e-Tendering. The e-Tendering design based on the RUP approach can contribute to e-Tendering developers and researchers in e-Tendering domain. In addition, this study also shows that the RUP is one of the best system development methodology that can be used as one of the research methodology in Software Engineering domain related to secured design of any observed application. This methodology has been tested in various studies in certain domains, such as in Simulation-based Decision Support, Security Requirement Engineering, Business Modeling and Secure System Requirement, and so forth. As a conclusion, these studies showed that the RUP one of a good research methodology that can be adapted in any Software Engineering (SE) research domain that required a few artifacts to be generated such as use case modeling, misuse case modeling, activity

  19. French vertical-flow constructed wetland design: adaptations for tropical climates.

    PubMed

    Molle, P; Latune, R Lombard; Riegel, C; Lacombe, G; Esser, D; Mangeot, L

    2015-01-01

    The French Outermost Regions are under tropical climate yet still have to comply with both French and EU regulations. French vertical-flow constructed wetland systems appear well adapted to the technical specifics of these regions but their adaptation to tropical climate requires new design guidelines to be defined (area needed, number of filters, type of plants, material to be used, etc.). A study was started in 2008, with backing from the national water authorities, to implement full-scale experimental sites and assess the impacts of local context on design and performances. This paper reports the monitoring results on three vertical-flow constructed wetlands fed directly with raw wastewater (known as the 'French system') in Mayotte and French Guiana. The plants, now in operation for between 1 and 6 years, range from 160 to 480 population equivalent (p.e.). Monitoring consisted of 28 daily composite flow samples in different seasons (dry season, rainy season) at the inlet and outlet of each filter. Performances are benchmarked against French mainland area standards from Irstea's database. Results show that performances are improved by warmer temperature for chemical oxygen demand (COD), suspended solids (SS) and total Kjeldahl nitrogen (TKN) and satisfy national quality objectives with a single stage of filters. Treatment plant footprint can thus be reduced as only two parallel filters are needed. Indeed, warm temperatures allow faster mineralization of the sludge deposit, making it possible to operate at similar rest and feeding period durations. Systems operated using one twin-filter stage can achieve over 90% COD, SS and TKN removal for a total surface of 0.8 m²/p.e.

  20. French vertical-flow constructed wetland design: adaptations for tropical climates.

    PubMed

    Molle, P; Latune, R Lombard; Riegel, C; Lacombe, G; Esser, D; Mangeot, L

    2015-01-01

    The French Outermost Regions are under tropical climate yet still have to comply with both French and EU regulations. French vertical-flow constructed wetland systems appear well adapted to the technical specifics of these regions but their adaptation to tropical climate requires new design guidelines to be defined (area needed, number of filters, type of plants, material to be used, etc.). A study was started in 2008, with backing from the national water authorities, to implement full-scale experimental sites and assess the impacts of local context on design and performances. This paper reports the monitoring results on three vertical-flow constructed wetlands fed directly with raw wastewater (known as the 'French system') in Mayotte and French Guiana. The plants, now in operation for between 1 and 6 years, range from 160 to 480 population equivalent (p.e.). Monitoring consisted of 28 daily composite flow samples in different seasons (dry season, rainy season) at the inlet and outlet of each filter. Performances are benchmarked against French mainland area standards from Irstea's database. Results show that performances are improved by warmer temperature for chemical oxygen demand (COD), suspended solids (SS) and total Kjeldahl nitrogen (TKN) and satisfy national quality objectives with a single stage of filters. Treatment plant footprint can thus be reduced as only two parallel filters are needed. Indeed, warm temperatures allow faster mineralization of the sludge deposit, making it possible to operate at similar rest and feeding period durations. Systems operated using one twin-filter stage can achieve over 90% COD, SS and TKN removal for a total surface of 0.8 m²/p.e. PMID:26442494

  1. Design For Six Sigma with Critical-To-Quality Metrics for Research Investments

    SciTech Connect

    Logan, R W

    2005-06-22

    Design for Six Sigma (DFSS) has evolved as a worthy predecessor to the application of Six-Sigma principles to production, process control, and quality. At Livermore National Laboratory (LLNL), we are exploring the interrelation of our current research, development, and design safety standards as they would relate to the principles of DFSS and Six-Sigma. We have had success in prioritization of research and design using a quantitative scalar metric for value, so we further explore the use of scalar metrics to represent the outcome of our use of the DFSS process. We use the design of an automotive component as an example of combining DFSS metrics into a scalar decision quantity. We then extend this concept to a high-priority, personnel safety example representing work that is toward the mature end of DFSS, and begins the transition into Six-Sigma for safety assessments in a production process. This latter example and objective involves the balance of research investment, quality control, and system operation and maintenance of high explosive handling at LLNL and related production facilities. Assuring a sufficiently low probability of failure (reaction of a high explosive given an accidental impact) is a Critical-To-Quality (CTQ) component of our weapons and stockpile stewardship operation and cost. Our use of DFSS principles, with quantification and merging of CTQ metrics, provides ways to quantify clear (preliminary) paths forward for both the automotive example and the explosive safety example. The presentation of simple, scalar metrics to quantify the path forward then provides a focal point for qualitative caveats and discussion for inclusion of other metrics besides a single, provocative scalar. In this way, carrying a scalar decision metric along with the DFSS process motivates further discussion and ideas for process improvement from the DFSS into the Six-Sigma phase of the product. We end with an example of how our DFSS-generated scalar metric could be

  2. Application of Adaptive Design Methodology in Development of a Long-Acting Glucagon-Like Peptide-1 Analog (Dulaglutide): Statistical Design and Simulations

    PubMed Central

    Skrivanek, Zachary; Berry, Scott; Berry, Don; Chien, Jenny; Geiger, Mary Jane; Anderson, James H.; Gaydos, Brenda

    2012-01-01

    Background Dulaglutide (dula, LY2189265), a long-acting glucagon-like peptide-1 analog, is being developed to treat type 2 diabetes mellitus. Methods To foster the development of dula, we designed a two-stage adaptive, dose-finding, inferentially seamless phase 2/3 study. The Bayesian theoretical framework is used to adaptively randomize patients in stage 1 to 7 dula doses and, at the decision point, to either stop for futility or to select up to 2 dula doses for stage 2. After dose selection, patients continue to be randomized to the selected dula doses or comparator arms. Data from patients assigned the selected doses will be pooled across both stages and analyzed with an analysis of covariance model, using baseline hemoglobin A1c and country as covariates. The operating characteristics of the trial were assessed by extensive simulation studies. Results Simulations demonstrated that the adaptive design would identify the correct doses 88% of the time, compared to as low as 6% for a fixed-dose design (the latter value based on frequentist decision rules analogous to the Bayesian decision rules for adaptive design). Conclusions This article discusses the decision rules used to select the dula dose(s); the mathematical details of the adaptive algorithm—including a description of the clinical utility index used to mathematically quantify the desirability of a dose based on safety and efficacy measurements; and a description of the simulation process and results that quantify the operating characteristics of the design. PMID:23294775

  3. Adaptive Flight Control Design with Optimal Control Modification on an F-18 Aircraft Model

    NASA Technical Reports Server (NTRS)

    Burken, John J.; Nguyen, Nhan T.; Griffin, Brian J.

    2010-01-01

    In the presence of large uncertainties, a control system needs to be able to adapt rapidly to regain performance. Fast adaptation is referred to as the implementation of adaptive control with a large adaptive gain to reduce the tracking error rapidly; however, a large adaptive gain can lead to high-frequency oscillations which can adversely affect the robustness of an adaptive control law. A new adaptive control modification is presented that can achieve robust adaptation with a large adaptive gain without incurring high-frequency oscillations as with the standard model-reference adaptive control. The modification is based on the minimization of the Y2 norm of the tracking error, which is formulated as an optimal control problem. The optimality condition is used to derive the modification using the gradient method. The optimal control modification results in a stable adaptation and allows a large adaptive gain to be used for better tracking while providing sufficient robustness. A damping term (v) is added in the modification to increase damping as needed. Simulations were conducted on a damaged F-18 aircraft (McDonnell Douglas, now The Boeing Company, Chicago, Illinois) with both the standard baseline dynamic inversion controller and the adaptive optimal control modification technique. The results demonstrate the effectiveness of the proposed modification in tracking a reference model.

  4. A review of potential methods of determining critical effect size for designing environmental monitoring programs.

    PubMed

    Munkittrick, Kelly R; Arens, Collin J; Lowell, Richard B; Kaminski, Greg P

    2009-07-01

    The effective design of field studies requires that sample size requirements be estimated for important endpoints before conducting assessments. This a priori calculation of sample size requires initial estimates for the variability of the endpoints of interest, decisions regarding significance levels and the power desired, and identification of an effect size to be detected. Although many programs have called for use of critical effect sizes (CES) in the design of monitoring programs, few attempts have been made to define them. This paper reviews approaches that have been or could be used to set specific CES. The ideal method for setting CES would be to define the level of protection that prevents ecologically relevant impacts and to set a warning level of change that would be more sensitive than that CES level to provide a margin of safety; however, few examples of this approach being applied exist. Program-specific CES could be developed through the use of numbers based on regulatory or detection limits, a number defined through stakeholder negotiation, estimates of the ranges of reference data, or calculation from the distribution of data using frequency plots or multivariate techniques. The CES that have been defined often are consistent with a CES of approximately 25%, or two standard deviations, for many biological or ecological monitoring endpoints, and this value appears to be reasonable for use in a wide variety of monitoring programs and with a wide variety of endpoints.

  5. Adapting water treatment design and operations to the impacts of global climate change

    NASA Astrophysics Data System (ADS)

    Clark, Robert M.; Li, Zhiwei; Buchberger, Steven G.

    2011-12-01

    It is anticipated that global climate change will adversely impact source water quality in many areas of the United States and will therefore, potentially, impact the design and operation of current and future water treatment systems. The USEPA has initiated an effort called the Water Resources Adaptation Program (WRAP) which is intended to develop tools and techniques that can assess the impact of global climate change on urban drinking water and wastewater infrastructure. A three step approach for assessing climate change impacts on water treatment operation and design is being persude in this effort. The first step is the stochastic characterization of source water quality, the second step is the application of the USEPA Water Treatment Plant model and the third step is the application of cost algorithms to provide a metric that can be used to assess the coat impact of climate change. A model has been validated using data collected from Cincinnati's Richard Miller Water Treatment Plant for the USEPA Information Collection Rule (ICR) database. An analysis of the water treatment processes in response to assumed perturbations in raw water quality identified TOC, pH, and bromide as the three most important parameters affecting performance of the Miller WTP. The Miller Plant was simulated using the EPA WTP model to examine the impact of these parameters on selected regulated water quality parameters. Uncertainty in influent water quality was analyzed to estimate the risk of violating drinking water maximum contaminant levels (MCLs).Water quality changes in the Ohio River were projected for 2050 using Monte Carlo simulation and the WTP model was used to evaluate the effects of water quality changes on design and operation. Results indicate that the existing Miller WTP might not meet Safe Drinking Water Act MCL requirements for certain extreme future conditions. However, it was found that the risk of MCL violations under future conditions could be controlled by

  6. Genotypic Variation in Growth and Physiological Response to Drought Stress and Re-Watering Reveals the Critical Role of Recovery in Drought Adaptation in Maize Seedlings.

    PubMed

    Chen, Daoqian; Wang, Shiwen; Cao, Beibei; Cao, Dan; Leng, Guohui; Li, Hongbing; Yin, Lina; Shan, Lun; Deng, Xiping

    2015-01-01

    Non-irrigated crops in temperate climates and irrigated crops in arid climates are subjected to continuous cycles of water stress and re-watering. Thus, fast and efficient recovery from water stress may be among the key determinants of plant drought adaptation. The present study was designed to comparatively analyze the roles of drought resistance and drought recovery in drought adaptation and to investigate the physiological basis of genotypic variation in drought adaptation in maize (Zea mays) seedlings. As the seedlings behavior in growth associate with yield under drought, it could partly reflect the potential of drought adaptability. Growth and physiological responses to progressive drought stress and recovery were observed in seedlings of 10 maize lines. The results showed that drought adaptability is closely related to drought recovery (r = 0.714(**)), but not to drought resistance (r = 0.332). Drought induced decreases in leaf water content, water potential, osmotic potential, gas exchange parameters, chlorophyll content, Fv/Fm and nitrogen content, and increased H2O2 accumulation and lipid peroxidation. After recovery, most of these physiological parameters rapidly returned to normal levels. The physiological responses varied between lines. Further correlation analysis indicated that the physiological bases of drought resistance and drought recovery are definitely different, and that maintaining higher chlorophyll content (r = 0.874(***)) and Fv/Fm (r = 0.626(*)) under drought stress contributes to drought recovery. Our results suggest that both drought resistance and recovery are key determinants of plant drought adaptation, and that drought recovery may play a more important role than previously thought. In addition, leaf water potential, chlorophyll content and Fv/Fm could be used as efficient reference indicators in the selection of drought-adaptive genotypes. PMID:26793218

  7. Genotypic Variation in Growth and Physiological Response to Drought Stress and Re-Watering Reveals the Critical Role of Recovery in Drought Adaptation in Maize Seedlings

    PubMed Central

    Chen, Daoqian; Wang, Shiwen; Cao, Beibei; Cao, Dan; Leng, Guohui; Li, Hongbing; Yin, Lina; Shan, Lun; Deng, Xiping

    2016-01-01

    Non-irrigated crops in temperate climates and irrigated crops in arid climates are subjected to continuous cycles of water stress and re-watering. Thus, fast and efficient recovery from water stress may be among the key determinants of plant drought adaptation. The present study was designed to comparatively analyze the roles of drought resistance and drought recovery in drought adaptation and to investigate the physiological basis of genotypic variation in drought adaptation in maize (Zea mays) seedlings. As the seedlings behavior in growth associate with yield under drought, it could partly reflect the potential of drought adaptability. Growth and physiological responses to progressive drought stress and recovery were observed in seedlings of 10 maize lines. The results showed that drought adaptability is closely related to drought recovery (r = 0.714**), but not to drought resistance (r = 0.332). Drought induced decreases in leaf water content, water potential, osmotic potential, gas exchange parameters, chlorophyll content, Fv/Fm and nitrogen content, and increased H2O2 accumulation and lipid peroxidation. After recovery, most of these physiological parameters rapidly returned to normal levels. The physiological responses varied between lines. Further correlation analysis indicated that the physiological bases of drought resistance and drought recovery are definitely different, and that maintaining higher chlorophyll content (r = 0.874***) and Fv/Fm (r = 0.626*) under drought stress contributes to drought recovery. Our results suggest that both drought resistance and recovery are key determinants of plant drought adaptation, and that drought recovery may play a more important role than previously thought. In addition, leaf water potential, chlorophyll content and Fv/Fm could be used as efficient reference indicators in the selection of drought-adaptive genotypes. PMID:26793218

  8. Design of Field Experiments for Adaptive Sampling of the Ocean with Autonomous Vehicles

    NASA Astrophysics Data System (ADS)

    Zheng, H.; Ooi, B. H.; Cho, W.; Dao, M. H.; Tkalich, P.; Patrikalakis, N. M.

    2010-05-01

    Due to the highly non-linear and dynamical nature of oceanic phenomena, the predictive capability of various ocean models depends on the availability of operational data. A practical method to improve the accuracy of the ocean forecast is to use a data assimilation methodology to combine in-situ measured and remotely acquired data with numerical forecast models of the physical environment. Autonomous surface and underwater vehicles with various sensors are economic and efficient tools for exploring and sampling the ocean for data assimilation; however there is an energy limitation to such vehicles, and thus effective resource allocation for adaptive sampling is required to optimize the efficiency of exploration. In this paper, we use physical oceanography forecasts of the coastal zone of Singapore for the design of a set of field experiments to acquire useful data for model calibration and data assimilation. The design process of our experiments relied on the oceanography forecast including the current speed, its gradient, and vorticity in a given region of interest for which permits for field experiments could be obtained and for time intervals that correspond to strong tidal currents. Based on these maps, resources available to our experimental team, including Autonomous Surface Craft (ASC) are allocated so as to capture the oceanic features that result from jets and vortices behind bluff bodies (e.g., islands) in the tidal current. Results are summarized from this resource allocation process and field experiments conducted in January 2009.

  9. Human-Automation Interaction Design for Adaptive Cruise Control Systems of Ground Vehicles.

    PubMed

    Eom, Hwisoo; Lee, Sang Hun

    2015-01-01

    A majority of recently developed advanced vehicles have been equipped with various automated driver assistance systems, such as adaptive cruise control (ACC) and lane keeping assistance systems. ACC systems have several operational modes, and drivers can be unaware of the mode in which they are operating. Because mode confusion is a significant human error factor that contributes to traffic accidents, it is necessary to develop user interfaces for ACC systems that can reduce mode confusion. To meet this requirement, this paper presents a new human-automation interaction design methodology in which the compatibility of the machine and interface models is determined using the proposed criteria, and if the models are incompatible, one or both of the models is/are modified to make them compatible. To investigate the effectiveness of our methodology, we designed two new interfaces by separately modifying the machine model and the interface model and then performed driver-in-the-loop experiments. The results showed that modifying the machine model provides a more compact, acceptable, effective, and safe interface than modifying the interface model. PMID:26076406

  10. Human-Automation Interaction Design for Adaptive Cruise Control Systems of Ground Vehicles.

    PubMed

    Eom, Hwisoo; Lee, Sang Hun

    2015-01-01

    A majority of recently developed advanced vehicles have been equipped with various automated driver assistance systems, such as adaptive cruise control (ACC) and lane keeping assistance systems. ACC systems have several operational modes, and drivers can be unaware of the mode in which they are operating. Because mode confusion is a significant human error factor that contributes to traffic accidents, it is necessary to develop user interfaces for ACC systems that can reduce mode confusion. To meet this requirement, this paper presents a new human-automation interaction design methodology in which the compatibility of the machine and interface models is determined using the proposed criteria, and if the models are incompatible, one or both of the models is/are modified to make them compatible. To investigate the effectiveness of our methodology, we designed two new interfaces by separately modifying the machine model and the interface model and then performed driver-in-the-loop experiments. The results showed that modifying the machine model provides a more compact, acceptable, effective, and safe interface than modifying the interface model.

  11. Human-Automation Interaction Design for Adaptive Cruise Control Systems of Ground Vehicles

    PubMed Central

    Eom, Hwisoo; Lee, Sang Hun

    2015-01-01

    A majority of recently developed advanced vehicles have been equipped with various automated driver assistance systems, such as adaptive cruise control (ACC) and lane keeping assistance systems. ACC systems have several operational modes, and drivers can be unaware of the mode in which they are operating. Because mode confusion is a significant human error factor that contributes to traffic accidents, it is necessary to develop user interfaces for ACC systems that can reduce mode confusion. To meet this requirement, this paper presents a new human-automation interaction design methodology in which the compatibility of the machine and interface models is determined using the proposed criteria, and if the models are incompatible, one or both of the models is/are modified to make them compatible. To investigate the effectiveness of our methodology, we designed two new interfaces by separately modifying the machine model and the interface model and then performed driver-in-the-loop experiments. The results showed that modifying the machine model provides a more compact, acceptable, effective, and safe interface than modifying the interface model. PMID:26076406

  12. Rational design and adaptive management of combination therapies for Hepatitis C virus infection

    SciTech Connect

    Ke, Ruian; Loverdo, Claude; Qi, Hangfei; Sun, Ren; Lloyd-Smith, James O.; Kouyos, Roger Dimitri

    2015-06-30

    Recent discoveries of direct acting antivirals against Hepatitis C virus (HCV) have raised hopes of effective treatment via combination therapies. Yet rapid evolution and high diversity of HCV populations, combined with the reality of suboptimal treatment adherence, make drug resistance a clinical and public health concern. We develop a general model incorporating viral dynamics and pharmacokinetics/ pharmacodynamics to assess how suboptimal adherence affects resistance development and clinical outcomes. We derive design principles and adaptive treatment strategies, identifying a high-risk period when missing doses is particularly risky for de novo resistance, and quantifying the number of additional doses needed to compensate when doses are missed. Using data from large-scale resistance assays, we demonstrate that the risk of resistance can be reduced substantially by applying these principles to a combination therapy of daclatasvir and asunaprevir. By providing a mechanistic framework to link patient characteristics to the risk of resistance, these findings show the potential of rational treatment design.

  13. Adaptive Signal Recovery on Graphs via Harmonic Analysis for Experimental Design in Neuroimaging

    PubMed Central

    Kim, Won Hwa; Hwang, Seong Jae; Adluru, Nagesh; Johnson, Sterling C.; Singh, Vikas

    2016-01-01

    Consider an experimental design of a neuroimaging study, where we need to obtain p measurements for each participant in a setting where p′ (< p) are cheaper and easier to acquire while the remaining (p – p′) are expensive. For example, the p′ measurements may include demographics, cognitive scores or routinely offered imaging scans while the (p – p′) measurements may correspond to more expensive types of brain image scans with a higher participant burden. In this scenario, it seems reasonable to seek an “adaptive” design for data acquisition so as to minimize the cost of the study without compromising statistical power. We show how this problem can be solved via harmonic analysis of a band-limited graph whose vertices correspond to participants and our goal is to fully recover a multi-variate signal on the nodes, given the full set of cheaper features and a partial set of more expensive measurements. This is accomplished using an adaptive query strategy derived from probing the properties of the graph in the frequency space. To demonstrate the benefits that this framework can provide, we present experimental evaluations on two independent neuroimaging studies and show that our proposed method can reliably recover the true signal with only partial observations directly yielding substantial financial savings. PMID:27807594

  14. Rational design and adaptive management of combination therapies for Hepatitis C virus infection

    DOE PAGES

    Ke, Ruian; Loverdo, Claude; Qi, Hangfei; Sun, Ren; Lloyd-Smith, James O.; Kouyos, Roger Dimitri

    2015-06-30

    Recent discoveries of direct acting antivirals against Hepatitis C virus (HCV) have raised hopes of effective treatment via combination therapies. Yet rapid evolution and high diversity of HCV populations, combined with the reality of suboptimal treatment adherence, make drug resistance a clinical and public health concern. We develop a general model incorporating viral dynamics and pharmacokinetics/ pharmacodynamics to assess how suboptimal adherence affects resistance development and clinical outcomes. We derive design principles and adaptive treatment strategies, identifying a high-risk period when missing doses is particularly risky for de novo resistance, and quantifying the number of additional doses needed to compensatemore » when doses are missed. Using data from large-scale resistance assays, we demonstrate that the risk of resistance can be reduced substantially by applying these principles to a combination therapy of daclatasvir and asunaprevir. By providing a mechanistic framework to link patient characteristics to the risk of resistance, these findings show the potential of rational treatment design.« less

  15. Circuit Design and Simulation of AN Augmented Adaptive Resonance Theory (aart) Neural Network.

    NASA Astrophysics Data System (ADS)

    Ho, Ching-Sung

    This dissertation presents circuit implementations for an binary-input adaptive resonance theory neural network architecture, called the augmented ART-1 neural network (AART1-NN). The AART1-NN is a modification of the popular ART1-NN, developed by Carpenter and Grossberg, and it exhibits the same behavior as the ART1-NN. The AART1-NN is a real -time model, and has the ability to classify an arbitrary set of binary input patterns into different clusters. The design of the AART1-NN circuit is based on a set of coupled nonlinear differential equations that constitute the AART1 -NN model. Various ways are examined to implement an efficient and practical AART1-NN in electronic hardware. They include designing circuits of AART1-NN by means of discrete electronic components, such as operational amplifiers, capacitors, and resistors, digital VLSI circuit, and mixed analog/digital VLSI circuit. The implemented circuit prototypes are verified using the PSpice circuit simulator, running on Sun workstations. Results obtained from PSpice circuit simulations are also compared with results obtained by solving the coupled differential equations numerically. The prototype systems developed in this work can be used as building blocks for larger AART1-NN architectures, as well as for other types of ART architectures that involve the AART1-NN model.

  16. Toward Design of an Environment-Aware Adaptive Locomotion-Mode-Recognition System

    PubMed Central

    Du, Lin; Zhang, Fan; Liu, Ming

    2013-01-01

    In this study, we aimed to improve the performance of a locomotion-mode-recognition system based on neuromuscular-mechanical fusion by introducing additional information about the walking environment. Linear-discriminant-analysis-based classifiers were first designed to identify a lower limb prosthesis user’s locomotion mode based on electromyographic signals recorded from residual leg muscles and ground reaction forces measured from the prosthetic pylon. Nine transfemoral amputees who wore a passive hydraulic knee or powered prosthetic knee participated in this study. Information about the walking terrain was simulated and modeled as prior probability based on the principle of maximum entropy and integrated into the discriminant functions of the classifier. When the correct prior knowledge of walking terrain was simulated, the classification accuracy for each locomotion mode significantly increased and no task transitions were missed. In addition, simulated incorrect prior knowledge did not significantly reduce system performance, indicating that our design is robust against noisy and imperfect prior information. Furthermore, these observations were independent of the type of prosthesis applied. The promising results in this study may assist the further development of an environment-aware adaptive system for locomotion-mode recognition for powered lower limb prostheses or orthoses. PMID:22996721

  17. Flexible design and efficient implementation of adaptive dose-finding studies.

    PubMed

    Weir, Christopher J; Spiegelhalter, David J; Grieve, Andrew P

    2007-01-01

    A dose-finding study with an adaptive design generates three computational problems: fitting the dose-response curve given the current data, identifying the dose to be given to the next patient that is optimal for learning about the dose-response curve, and pretrial simulation in order to establish operating characteristics of alternative designs. Identifying the 'optimal' dose is the rate-limiting step since conventional methods, estimating the full posterior predictive distribution of some utility function under each of the possible doses, are very slow. We explore a simpler strategy based on importance sampling, whereby the posterior mean of the utility at each candidate dose is estimated by taking its average across an empirical distribution for the model parameters from the current Markov chain Monte Carlo (MCMC) run, weighted according to the likelihood of one or more predicted observations. We identify appropriate settings for this algorithm and illustrate its application in the context of a normal dynamic linear model used in a dose-finding clinical trial of a neutrophil inhibitory factor in acute ischaemic stroke. PMID:18027215

  18. How to Represent Adaptation in e-Learning with IMS Learning Design

    ERIC Educational Resources Information Center

    Burgos, Daniel; Tattersall, Colin; Koper, Rob

    2007-01-01

    Adaptation in e-learning has been an important research topic for the last few decades in computer-based education. In adaptivity the behaviour of the user triggers some actions in the system that guides the learning process. In adaptability, the user makes changes and takes decisions. Progressing from computer-based training and adaptive…

  19. Experimental Design and Primary Data Analysis Methods for Comparing Adaptive Interventions

    ERIC Educational Resources Information Center

    Nahum-Shani, Inbal; Qian, Min; Almirall, Daniel; Pelham, William E.; Gnagy, Beth; Fabiano, Gregory A.; Waxmonsky, James G.; Yu, Jihnhee; Murphy, Susan A.

    2012-01-01

    In recent years, research in the area of intervention development has been shifting from the traditional fixed-intervention approach to "adaptive interventions," which allow greater individualization and adaptation of intervention options (i.e., intervention type and/or dosage) over time. Adaptive interventions are operationalized via a sequence…

  20. p21Cip1 plays a critical role in the physiological adaptation to fasting through activation of PPARα

    PubMed Central

    Lopez-Guadamillas, Elena; Fernandez-Marcos, Pablo J.; Pantoja, Cristina; Muñoz-Martin, Maribel; Martínez, Dolores; Gómez-López, Gonzalo; Campos-Olivas, Ramón; Valverde, Angela M.; Serrano, Manuel

    2016-01-01

    Fasting is a physiological stress that elicits well-known metabolic adaptations, however, little is known about the role of stress-responsive tumor suppressors in fasting. Here, we have examined the expression of several tumor suppressors upon fasting in mice. Interestingly, p21 mRNA is uniquely induced in all the tissues tested, particularly in liver and muscle (>10 fold), and this upregulation is independent of p53. Remarkably, in contrast to wild-type mice, p21-null mice become severely morbid after prolonged fasting. The defective adaptation to fasting of p21-null mice is associated to elevated energy expenditure, accelerated depletion of fat stores, and premature activation of protein catabolism in the muscle. Analysis of the liver transcriptome and cell-based assays revealed that the absence of p21 partially impairs the transcriptional program of PPARα, a key regulator of fasting metabolism. Finally, treatment of p21-null mice with a PPARα agonist substantially protects them from their accelerated loss of fat upon fasting. We conclude that p21 plays a relevant role in fasting adaptation through the positive regulation of PPARα. PMID:27721423