38 CFR 3.809a - Special home adaptation grants under 38 U.S.C. 2101(b).

Code of Federal Regulations, 2014 CFR

2014-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 1 2014-07-01 2014-07-01 false Special home adaptation... Special Benefits § 3.809a Special home adaptation grants under 38 U.S.C. 2101(b). A certificate of eligibility for assistance in acquiring necessary special home adaptations, or, on or after October 28, 1986...

Conditions for Fully Autonomous Anticipation

NASA Astrophysics Data System (ADS)

Collier, John

2006-06-01

Anticipation allows a system to adapt to conditions that have not yet come to be, either externally to the system or internally. Autonomous systems actively control the conditions of their own existence so as to increase their overall viability. This paper will first give minimal necessary and sufficient conditions for autonomous anticipation, followed by a taxonomy of autonomous anticipation. In more complex systems, there can be semi-autonomous subsystems that can anticipate and adapt on their own. Such subsystems can be integrated into a system's overall autonomy, typically with greater efficiency due to modularity and specialization of function. However, it is also possible that semi-autonomous subsystems can act against the viability of the overall system, and have their own functions that conflict with overall system functions.

D-loop haplotype diversity in Brazilian horse breeds

PubMed Central

Ianella, Patrícia; Albuquerque, Maria do Socorro Maués; Paiva, Samuel Rezende; do Egito, Andréa Alves; Almeida, Leonardo Daniel; Sereno, Fabiana T. P. S.; Carvalho, Luiz Felipe Ramos; Mariante, Arthur da Silva; McManus, Concepta Margaret

2017-01-01

Abstract The first horses were brought to Brazil by the colonizers after 1534. Over the centuries, these animals evolved and adapted to local environmental conditions usually unsuitable for exotic breeds, thereby originating locally adapted Brazilian breeds. The present work represents the first description of maternal genetic diversity in these horse breeds based on D-loop sequences. A D-Loop HSV-I fragment of 252 bp, from 141 horses belonging to ten Brazilian breeds / genetic groups (locally adapted and specialized breeds) were analysed. Thirty-five different haplotypes belonging to 18 haplogroups were identified with 33 polymorphic sites. Haplotype diversity (varying from 0.20 to 0.96) and nucleotide diversity (varying from 0.0039 to 0.0239) was lower for locally adapted than for specialized breeds, with the same pattern observed for FST values. Haplogroups identified in Brazilian breeds are in agreement with previous findings in South American samples. The low variability observed mainly in locally adapted breeds, indicates that, to ensure conservation of these breeds, careful reproductive management is needed. Additional genetic characterization studies are required to support accurate decision-making. PMID:28863209

Fault Tolerance Analysis of L1 Adaptive Control System for Unmanned Aerial Vehicles

NASA Astrophysics Data System (ADS)

Krishnamoorthy, Kiruthika

Trajectory tracking is a critical element for the better functionality of autonomous vehicles. The main objective of this research study was to implement and analyze L1 adaptive control laws for autonomous flight under normal and upset flight conditions. The West Virginia University (WVU) Unmanned Aerial Vehicle flight simulation environment was used for this purpose. A comparison study between the L1 adaptive controller and a baseline conventional controller, which relies on position, proportional, and integral compensation, has been performed for a reduced size jet aircraft, the WVU YF-22. Special attention was given to the performance of the proposed control laws in the presence of abnormal conditions. The abnormal conditions considered are locked actuators (stabilator, aileron, and rudder) and excessive turbulence. Several levels of abnormal condition severity have been considered. The performance of the control laws was assessed over different-shape commanded trajectories. A set of comprehensive evaluation metrics was defined and used to analyze the performance of autonomous flight control laws in terms of control activity and trajectory tracking errors. The developed L1 adaptive control laws are supported by theoretical stability guarantees. The simulation results show that L1 adaptive output feedback controller achieves better trajectory tracking with lower level of control actuation as compared to the baseline linear controller under nominal and abnormal conditions.

RESILIENCE TO DROUGHTS IN MAMMALS: A CONCEPTUAL FRAMEWORK FOR ESTIMATING VULNERABILITY OF A SINGLE SPECIES.

PubMed

Rymer, Tasmin L; Pillay, Neville; Schradin, Carsten

2016-06-01

ABSTRACT The frequency and severity of droughts in certain areas is increasing as a consequence of climate change. The associated environmental challenges, including high temperatures, low food, and water availability, have affected, and will affect, many populations. Our aims are to review the behavioral, physiological, and morphological adaptations of mammals to arid environments, and to aid research- ers and nature conservationists about which traits they should study to assess whether or not their study species will be able to cope with droughts. We provide a suite of traits that should be considered when making predictions about species resilience to drought. We define and differentiate between general adaptations, specialized adaptations, and exaptations, and argue that specialized adaptations are of little interest in establishing how nondesert specialists will cope with droughts. Attention should be placed on general adaptations of semidesert species and assess whether these exist as exaptations in nondesert species. We conclude that phenotypic flexibility is the most important general adaptation that may promote species resilience. Thus, to assess whether a species will be able to cope with increasing aridity, it is important to establish the degree offlexibility of traits identified in semidesert species that confer afitness advantage under drying conditions.

The research on thermal adaptability reinforcement technology for photovoltaic modules

NASA Astrophysics Data System (ADS)

Su, Nana; Zhou, Guozhong

2015-10-01

Nowadays, Photovoltaic module contains more high-performance components in smaller space. It is also demanded to work in severe temperature condition for special use, such as aerospace. As temperature rises, the failure rate will increase exponentially which makes reliability significantly reduce. In order to improve thermal adaptability of photovoltaic module, this paper makes a research on reinforcement technologies. Thermoelectric cooler is widely used in aerospace which has harsh working environment. So, theoretical formulas for computing refrigerating efficiency, refrigerating capacity and temperature difference are described in detail. The optimum operating current of three classical working condition is obtained which can be used to guide the design of driven circuit. Taken some equipment enclosure for example, we use thermoelectric cooler to reinforce its thermal adaptability. By building physical model and thermal model with the aid of physical dimension and constraint condition, the model is simulated by Flotherm. The temperature field cloud is shown to verify the effectiveness of reinforcement.

Predatory cannibalism in Drosophila melanogaster larvae.

PubMed

Vijendravarma, Roshan K; Narasimha, Sunitha; Kawecki, Tadeusz J

2013-01-01

Hunting live prey is risky and thought to require specialized adaptations. Therefore, observations of predatory cannibalism in otherwise non-carnivorous animals raise questions about its function, adaptive significance and evolutionary potential. Here we document predatory cannibalism on larger conspecifics in Drosophila melanogaster larvae and address its evolutionary significance. We found that under crowded laboratory conditions younger larvae regularly attack and consume 'wandering-stage' conspecifics, forming aggregations mediated by chemical cues from the attacked victim. Nutrition gained this way can be significant: an exclusively cannibalistic diet was sufficient for normal development from eggs to fertile adults. Cannibalistic diet also induced plasticity of larval mouth parts. Finally, during 118 generations of experimental evolution, replicated populations maintained under larval malnutrition evolved enhanced propensity towards cannibalism. These results suggest that, at least under laboratory conditions, predation on conspecifics in Drosophila is a functional, adaptive behaviour, which can rapidly evolve in response to nutritional conditions.

Colloquium paper: adaptive specializations, social exchange, and the evolution of human intelligence.

PubMed

Cosmides, Leda; Barrett, H Clark; Tooby, John

2010-05-11

Blank-slate theories of human intelligence propose that reasoning is carried out by general-purpose operations applied uniformly across contents. An evolutionary approach implies a radically different model of human intelligence. The task demands of different adaptive problems select for functionally specialized problem-solving strategies, unleashing massive increases in problem-solving power for ancestrally recurrent adaptive problems. Because exchange can evolve only if cooperators can detect cheaters, we hypothesized that the human mind would be equipped with a neurocognitive system specialized for reasoning about social exchange. Whereas humans perform poorly when asked to detect violations of most conditional rules, we predicted and found a dramatic spike in performance when the rule specifies an exchange and violations correspond to cheating. According to critics, people's uncanny accuracy at detecting violations of social exchange rules does not reflect a cheater detection mechanism, but extends instead to all rules regulating when actions are permitted (deontic conditionals). Here we report experimental tests that falsify these theories by demonstrating that deontic rules as a class do not elicit the search for violations. We show that the cheater detection system functions with pinpoint accuracy, searching for violations of social exchange rules only when these are likely to reveal the presence of someone who intends to cheat. It does not search for violations of social exchange rules when these are accidental, when they do not benefit the violator, or when the situation would make cheating difficult.

Adaptive specializations, social exchange, and the evolution of human intelligence

PubMed Central

Cosmides, Leda; Barrett, H. Clark; Tooby, John

2010-01-01

Blank-slate theories of human intelligence propose that reasoning is carried out by general-purpose operations applied uniformly across contents. An evolutionary approach implies a radically different model of human intelligence. The task demands of different adaptive problems select for functionally specialized problem-solving strategies, unleashing massive increases in problem-solving power for ancestrally recurrent adaptive problems. Because exchange can evolve only if cooperators can detect cheaters, we hypothesized that the human mind would be equipped with a neurocognitive system specialized for reasoning about social exchange. Whereas humans perform poorly when asked to detect violations of most conditional rules, we predicted and found a dramatic spike in performance when the rule specifies an exchange and violations correspond to cheating. According to critics, people's uncanny accuracy at detecting violations of social exchange rules does not reflect a cheater detection mechanism, but extends instead to all rules regulating when actions are permitted (deontic conditionals). Here we report experimental tests that falsify these theories by demonstrating that deontic rules as a class do not elicit the search for violations. We show that the cheater detection system functions with pinpoint accuracy, searching for violations of social exchange rules only when these are likely to reveal the presence of someone who intends to cheat. It does not search for violations of social exchange rules when these are accidental, when they do not benefit the violator, or when the situation would make cheating difficult. PMID:20445099

5 CFR 351.702 - Qualifications for assignment.

Code of Federal Regulations, 2010 CFR

2010-01-01

...) Meets the OPM standards and requirements for the position, including any minimum educational requirement... reasonable accommodation where appropriate, to perform the duties of the position; (3) Meets any special qualifying condition which the OPM has approved for the position; and (4) Has the capacity, adaptability, and...

What constitutes a natural fire regime? Insight from the ecology and distribution of coniferous forest birds in North America

Treesearch

Richard L. Hutto; Courtney J. Conway; Victoria A. Saab; Jeffrey R. Walters

2008-01-01

Bird species that specialize in the use of burned forest conditions can provide insight into the prehistoric fire regimes associated with the forest types that they have occupied over evolutionary time. The nature of their adaptations reflects the specific post-fire conditions that occurred prior to the unnatural influence of humans after European settlement....

Convergent Metabolic Specialization through Distinct Evolutionary Paths in Pseudomonas aeruginosa

PubMed Central

Johansen, Helle Krogh; Molin, Søren

2018-01-01

ABSTRACT Evolution by natural selection under complex and dynamic environmental conditions occurs through intricate and often counterintuitive trajectories affecting many genes and metabolic solutions. To study short- and long-term evolution of bacteria in vivo, we used the natural model system of cystic fibrosis (CF) infection. In this work, we investigated how and through which trajectories evolution of Pseudomonas aeruginosa occurs when migrating from the environment to the airways of CF patients, and specifically, we determined reduction of growth rate and metabolic specialization as signatures of adaptive evolution. We show that central metabolic pathways of three distinct Pseudomonas aeruginosa lineages coevolving within the same environment become restructured at the cost of versatility during long-term colonization. Cell physiology changes from naive to adapted phenotypes resulted in (i) alteration of growth potential that particularly converged to a slow-growth phenotype, (ii) alteration of nutritional requirements due to auxotrophy, (iii) tailored preference for carbon source assimilation from CF sputum, (iv) reduced arginine and pyruvate fermentation processes, and (v) increased oxygen requirements. Interestingly, although convergence was evidenced at the phenotypic level of metabolic specialization, comparative genomics disclosed diverse mutational patterns underlying the different evolutionary trajectories. Therefore, distinct combinations of genetic and regulatory changes converge to common metabolic adaptive trajectories leading to within-host metabolic specialization. This study gives new insight into bacterial metabolic evolution during long-term colonization of a new environmental niche. PMID:29636437

Research on intelligent monitoring technology of machining process

NASA Astrophysics Data System (ADS)

Wang, Taiyong; Meng, Changhong; Zhao, Guoli

1995-08-01

Based upon research on sound and vibration characteristics of tool condition, we explore the multigrade monitoring system which takes single-chip microcomputers as the core hardware. By using the specially designed pickup true signal devices, we can more effectively do the intelligent multigrade monitoring and forecasting, and furthermore, we can build the tool condition models adaptively. This is the key problem in FMS, CIMS, and even the IMS.

Focus on Ability: Serving Girls with Special Needs.

ERIC Educational Resources Information Center

Carroll, Martha E.; Dennison, Martha Jo

This handbook is designed to introduce adults in Girl Scouting to the rewards, pleasures, and challenges of working with girls who have disabilities. Included in the book are definitions of various disabling conditions, ways in which activities can be adapted, and behavioral expectations. Also included are activities for simulation of the…

Synchronization of coupled stochastic complex-valued dynamical networks with time-varying delays via aperiodically intermittent adaptive control

NASA Astrophysics Data System (ADS)

Wang, Pengfei; Jin, Wei; Su, Huan

2018-04-01

This paper deals with the synchronization problem of a class of coupled stochastic complex-valued drive-response networks with time-varying delays via aperiodically intermittent adaptive control. Different from the previous works, the intermittent control is aperiodic and adaptive, and the restrictions on the control width and time delay are removed, which lead to a larger application scope for this control strategy. Then, based on the Lyapunov method and Kirchhoff's Matrix Tree Theorem as well as differential inequality techniques, several novel synchronization conditions are derived for the considered model. Specially, impulsive control is also considered, which can be seen as a special case of the aperiodically intermittent control when the control width tends to zero. And the corresponding synchronization criteria are given as well. As an application of the theoretical results, a class of stochastic complex-valued coupled oscillators with time-varying delays is studied, and the numerical simulations are also given to demonstrate the effectiveness of the control strategies.

Effect of adaptation and pulp density on bioleaching of mine waste using indigenous acidophilic bacteria

NASA Astrophysics Data System (ADS)

Cho, K.; Kim, B.; Lee, D.; Choi, N.; Park, C.

2011-12-01

Adaptation to environment is a natural phenomena that takes place in many animals, plants and microorganisms. These adapted organisms achieve stronger applicability than unadapted organisms after habitation in a specific environment for a long time. In the biohydrometallurgical industry, adaptation to special environment conditions by selective culturing is the most popular method for improving bioleaching activity of strains-although that is time consuming. This study investigated the influence of the bioleaching efficiency of mine waste under batch experimental conditions (adaptation and pulp density) using the indigenous acidophilic bacteria collected from acid mine drainage in Go-seong and Yeon-hwa, Korea. We conducted the batch experiments at the influences of parameters, such as the adaptation of bacteria and pulp density of the mine waste. In the adaptation case, the value of pH in 1'st adaptation bacteria sample exhibited lower than in 2'nd adaptation bacteria sample. And the content of both Cu and Zn at 1'st adaptation bacteria sample appeared lower than at 2'nd adaptation bacteria sample. In the SEM analysis, the rod-shaped bacteria with 1μm in length were observed on the filter paper (pore size - 0.45μm). The results of pulp density experiments revealed that the content of both Cu and Zn increased with increasing pulp density, since the increment of pulp density resulted in the enhancement of bioleaching capacity.

Predation and Ecology in Deep-Time: How Modern Marine Ecosystems Develop and Deteriorate

NASA Astrophysics Data System (ADS)

Tackett, L.

2017-12-01

Anti-predator adaptations in shelly prey and specialized feeding-capture structures in predators can be observed nearly everywhere in modern oceans. The conditions in which these adaptive "arms-races" between predators and prey developed in the oceans can yield important insights to predict how these relationships are affected by environmental change. However, in the fossil record it can be difficult to determine if an adaptation in a shelly animal is related to predation, or some other factor, such as competition for nutrients or space. To address (1) the problem of interpreting the function of shelly invertebrate adaptations, and (2) to identify environmental factors in the development of modern predator-prey interactions, I carefully study the relative abundances of shelly prey animals and microfossil remains of their predators in marine sediments. In the Late Triassic (220-204 million years ago), a dramatic paleoecological shift occurred among shelly marine animals—immobile surface-dwelling animals that had been abundant in the oceans for 300 million years became rare, and were replaced by burrowing clams, swimming scallops, cementing oysters, and many other new taxa with surprising adaptations. This proliferation of adaptive strategies seems to be synchronous with the appearance of many predator taxa specialized for shell-crushing that mainly moved along the seafloor. To test this hypothesis, I examine microfossils of these predators in the sediments containing macrofossils of their shelly prey, to find teeth or claw features that can exhibit specializations for shell-crushing or other predation modes. With the development of this very modern system of predator-prey interactions, we can better understand how these food-webs were disrupted by climatic perturbations later in the Triassic, and make meaningful comparisons to modern ocean ecosystems.

78 FR 10266 - Proposed Information Collection (Veterans Application for Assistance in Acquiring Special Housing...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-13

... (Veterans Application for Assistance in Acquiring Special Housing Adaptations) Activity: Comment Request.../or adaptations to their current resident. DATES: Written comments and recommendations on the proposed... Special Housing Adaptations, VA Form 26-4555d. OMB Control Number: 2900-0300. Type of Review: Revision of...

75 FR 15494 - Proposed Information Collection (Veterans Application for Assistance in Acquiring Special Housing...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-29

... (Veterans Application for Assistance in Acquiring Special Housing Adaptations) Activity: Comment Request... adaptations to their current resident. DATES: Written comments and recommendations on the proposed collection... Special Housing Adaptations, VA Form 26-4555d. OMB Control Number: 2900-0300. Type of Review: Extension of...

75 FR 32540 - Agency Information Collection (Veterans Application for Assistance in Acquiring Special Housing...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-08

... Application for Assistance in Acquiring Special Housing Adaptations) Activity Under OMB Review AGENCY...: Veterans Application for Assistance in Acquiring Special Housing Adaptations, VA Form 26-4555d. OMB Control... dwellings. Grants are available to assist the veteran in making adaptations to their current residences or...

Adaptive management of natural resources-framework and issues

USGS Publications Warehouse

Williams, B.K.

2011-01-01

Adaptive management, an approach for simultaneously managing and learning about natural resources, has been around for several decades. Interest in adaptive decision making has grown steadily over that time, and by now many in natural resources conservation claim that adaptive management is the approach they use in meeting their resource management responsibilities. Yet there remains considerable ambiguity about what adaptive management actually is, and how it is to be implemented by practitioners. The objective of this paper is to present a framework and conditions for adaptive decision making, and discuss some important challenges in its application. Adaptive management is described as a two-phase process of deliberative and iterative phases, which are implemented sequentially over the timeframe of an application. Key elements, processes, and issues in adaptive decision making are highlighted in terms of this framework. Special emphasis is given to the question of geographic scale, the difficulties presented by non-stationarity, and organizational challenges in implementing adaptive management. ?? 2010.

Assessment in Early Intervention and Early Childhood Special Education: Building on the Past to Project into Our Future.

ERIC Educational Resources Information Center

McConnell, Scott R.

2000-01-01

This article discusses three future directions of early childhood assessment: attention to assessment of progress and growth, adaptation of methods typically associated with ecobehavioral research to assess environmental conditions that affect performance, and continued integration and linkage of assessment and intervention, which will yield more…

INTRODUCTION OF MANY-PARTICLE VARIABLES FOR THE TREATMENT OF SPECIAL TRANSLATIONALLY INVARIANT MANY-BODY PROBLEMS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mobius, P.

1960-05-01

An attempt is raade to treat special translationally invariant many-body problems by coordinate transformations introducing many-particle variables. These are adapted coordinates of such kind that the condition of translational invariance and the Pauli principle can be satisfied automatically. They are homogeneous functions of the particle coordinates obeying certain differential equations. The Schrodinger equation is transformed into these variables. There exist examples of systems of interacting particles which can be separated exactly in the many-particle variables but not in the particle coordinates. (auth)

Latitudinal variation in diapause duration and post-winter development in two pierid butterflies in relation to phenological specialization.

PubMed

Posledovich, Diana; Toftegaard, Tenna; Wiklund, Christer; Ehrlén, Johan; Gotthard, Karl

2015-01-01

Diapause plays a central role in insect life cycles by allowing survival during adverse seasonal conditions as well as synchronizing life cycles with the period of mate and food availability. Seasonal timing is expected to be particularly important for species that are dependent on resources available during a short time window-so-called phenological specialists-and latitudinal clines in seasonality are expected to favor local adaptation in phenological timing. However, to what degree latitudinal variation in diapause dynamics and post-winter development due to such local adaptation is influenced by the degree of phenological specialization is not well known. We experimentally studied two pierid butterfly species and found that the phenological specialist Anthocharis cardamines had shorter diapause duration than the phenological generalist Pieris napi along a latitudinal gradient in Sweden. Moreover, diapause duration increased with latitude in P. napi but not in A. cardamines. Sensitivity of the two species to winter thermal conditions also differed; additional cold temperature during the winter period shortened diapause duration for P. napi pupae but not for A. cardamines pupae. In both species, post-winter pupal development was faster after longer periods of cold conditions, and more southern populations developed faster than northern populations. Post-winter development was also invariably faster at higher temperatures in both species. We argue that the observed differences in diapause dynamics between the two species might be explained by the difference in phenological specialization that influences the costs of breaking diapause too early in the season.

75 FR 56875 - Loan Guaranty: Assistance to Eligible Individuals in Acquiring Specially Adapted Housing

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-17

... of braces, crutches, canes, or a wheelchair; (ii) Blindness in both eyes having only light perception... 38 U.S.C. chapter 11 for any of the following conditions: (i) Blindness in both eyes with 5/200... deny the housing unit acquired by this benefit, to any person because of race, color, religion, sex...

Bridge Building between North and South: Applied Technology for the Third World. Sonderdienst SO 2-87(e).

ERIC Educational Resources Information Center

Mensing, Friedhelm

In order to adapt new technologies and special processes to the particular conditions of developing nations, the German Appropriate Technology Exchange (GATE) was established in 1978 within the German Agency for Technical Cooperation (GTZ). This document traces the major aspects of cooperation between the Federal Republic of Germany and its…

Genomics of adaptation to host-plants in herbivorous insects.

PubMed

Simon, Jean-Christophe; d'Alençon, Emmanuelle; Guy, Endrick; Jacquin-Joly, Emmanuelle; Jaquiéry, Julie; Nouhaud, Pierre; Peccoud, Jean; Sugio, Akiko; Streiff, Réjane

2015-11-01

Herbivorous insects represent the most species-rich lineages of metazoans. The high rate of diversification in herbivorous insects is thought to result from their specialization to distinct host-plants, which creates conditions favorable for the build-up of reproductive isolation and speciation. These conditions rely on constraints against the optimal use of a wide range of plant species, as each must constitute a viable food resource, oviposition site and mating site for an insect. Utilization of plants involves many essential traits of herbivorous insects, as they locate and select their hosts, overcome their defenses and acquire nutrients while avoiding intoxication. Although advances in understanding insect-plant molecular interactions have been limited by the complexity of insect traits involved in host use and the lack of genomic resources and functional tools, recent studies at the molecular level, combined with large-scale genomics studies at population and species levels, are revealing the genetic underpinning of plant specialization and adaptive divergence in non-model insect herbivores. Here, we review the recent advances in the genomics of plant adaptation in hemipterans and lepidopterans, two major insect orders, each of which includes a large number of crop pests. We focus on how genomics and post-genomics have improved our understanding of the mechanisms involved in insect-plant interactions by reviewing recent molecular discoveries in sensing, feeding, digesting and detoxifying strategies. We also present the outcomes of large-scale genomics approaches aimed at identifying loci potentially involved in plant adaptation in these insects. © The Author 2015. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.

An introduction to adaptive management for threatened and endangered species

USGS Publications Warehouse

Runge, Michael C.

2011-01-01

Management of threatened and endangered species would seem to be a perfect context for adaptive management. Many of the decisions are recurrent and plagued by uncertainty, exactly the conditions that warrant an adaptive approach. But although the potential of adaptive management in these settings has been extolled, there are limited applications in practice. The impediments to practical implementation are manifold and include semantic confusion, institutional inertia, misperceptions about the suitability and utility, and a lack of guiding examples. In this special section of the Journal of Fish and Wildlife Management, we hope to reinvigorate the appropriate application of adaptive management for threatened and endangered species by framing such management in a decision-analytical context, clarifying misperceptions, classifying the types of decisions that might be amenable to an adaptive approach, and providing three fully developed case studies. In this overview paper, I define terms, review the past application of adaptive management, challenge perceived hurdles, and set the stage for the case studies which follow.

Wheelchair users' experience of non-adapted and adapted clothes during sailing, quad rugby or wheel-walking.

PubMed

Kratz, G; Söderback, I; Guidetti, S; Hultling, C; Rykatkin, T; Söderström, M

1997-01-01

The purpose of the present quasi-experimental post-test-design study was to compare 32 wheelchair users' (mostly para/tetraplegics) experience of wearing specially adapted clothes and non-adapted clothes for sailing, quad rugby or wheel-walking. Four existing assessment instruments were used: the Klein-Bell Activities of Daily Living Scale; a two-part Basic Information Questionnaire eliciting experience of effort, comfort and feeling of physical condition; the Experience Sampling Form for investigating the individuals' attitudes in terms of involvement and affective and activity mood states, and the Occupational Therapy Assessment of Leisure Time interview framework for collecting data about experience of leisure time. The wheelchair users all associated significantly greater comfort with use of the adapted clothes and, particularly the 'sailors', better physical condition. Overall, significantly greater involvement and more positive affect states were associated with the adapted clothes than with conventional garments, and mood state changed for the better. The wheelchair users set a higher priority upon work or leisure activities than upon independence in activities of daily living, and for this reason the Klein-Bell ratings showed great variation between the 'sailors' and the 'quad rugby players' (range 57%-93%), though these groups demonstrated more independence than the 'wheel-walkers'. The results of the study confirm the value of adapting sportswear for handicapped people. Such adaptations should also be of benefit for other activities than those studied.

Reliable video transmission over fading channels via channel state estimation

NASA Astrophysics Data System (ADS)

Kumwilaisak, Wuttipong; Kim, JongWon; Kuo, C.-C. Jay

2000-04-01

Transmission of continuous media such as video over time- varying wireless communication channels can benefit from the use of adaptation techniques in both source and channel coding. An adaptive feedback-based wireless video transmission scheme is investigated in this research with special emphasis on feedback-based adaptation. To be more specific, an interactive adaptive transmission scheme is developed by letting the receiver estimate the channel state information and send it back to the transmitter. By utilizing the feedback information, the transmitter is capable of adapting the level of protection by changing the flexible RCPC (rate-compatible punctured convolutional) code ratio depending on the instantaneous channel condition. The wireless channel is modeled as a fading channel, where the long-term and short- term fading effects are modeled as the log-normal fading and the Rayleigh flat fading, respectively. Then, its state (mainly the long term fading portion) is tracked and predicted by using an adaptive LMS (least mean squares) algorithm. By utilizing the delayed feedback on the channel condition, the adaptation performance of the proposed scheme is first evaluated in terms of the error probability and the throughput. It is then extended to incorporate variable size packets of ITU-T H.263+ video with the error resilience option. Finally, the end-to-end performance of wireless video transmission is compared against several non-adaptive protection schemes.

Transitions in optimal adaptive strategies for populations in fluctuating environments

NASA Astrophysics Data System (ADS)

Mayer, Andreas; Mora, Thierry; Rivoire, Olivier; Walczak, Aleksandra M.

2017-09-01

Biological populations are subject to fluctuating environmental conditions. Different adaptive strategies can allow them to cope with these fluctuations: specialization to one particular environmental condition, adoption of a generalist phenotype that compromises between conditions, or population-wise diversification (bet hedging). Which strategy provides the largest selective advantage in the long run depends on the range of accessible phenotypes and the statistics of the environmental fluctuations. Here, we analyze this problem in a simple mathematical model of population growth. First, we review and extend a graphical method to identify the nature of the optimal strategy when the environmental fluctuations are uncorrelated. Temporal correlations in environmental fluctuations open up new strategies that rely on memory but are mathematically challenging to study: We present analytical results to address this challenge. We illustrate our general approach by analyzing optimal adaptive strategies in the presence of trade-offs that constrain the range of accessible phenotypes. Our results extend several previous studies and have applications to a variety of biological phenomena, from antibiotic resistance in bacteria to immune responses in vertebrates.

Mismatch or cumulative stress: the pathway to depression is conditional on attention style.

PubMed

Nederhof, Esther; Ormel, Johan; Oldehinkel, Albertine J

2014-03-01

In the study reported here, the main question we investigated was whether attention style could be a conditional adaptation. We organized participants of the TRacking Adolescents' Individual Lives Survey (TRAILS; N = 2,230) into shifters, sustainers, and two comparison groups, depending on their performance on a shifting- and a sustained-attention task at age 11 years. Compared with sustainers, shifters reported more pre- and perinatal risk factors and more childhood stress, and they adopted a faster life-history strategy. These differences were not found between the comparison groups, who performed well or poorly on both tasks, which suggests that specialization for either sustained or shifting attention is the key to conditional adaptation. In a subsample (n = 860), we found that stress did not increase depression risk in shifters, whereas a mismatch between early and recent stress predicted depression in sustainers. Cumulative stress predicted depression in the comparison group. These results suggest that shifters retain high levels of plasticity throughout life, whereas sustainers' adapted their phenotype early in life to the expected mature environment.

How to Help Special Needs Children Adapt According to Their Own Abilities

ERIC Educational Resources Information Center

Cox, Dawndria

2013-01-01

The purpose of this project was to explore strategies of how to help special needs children adapt according to their own abilities. Contributing factors, such as discrimination practices, served as the foundational components that led to the formation of special education services. At one time, "special needs children," also referred to…

Medical Transport of Children with Complex Chronic Conditions

PubMed Central

Lerner, Carlos F.; Kelly, Robert B.; Hamilton, Leslie J.; Klitzner, Thomas S.

2012-01-01

One of the most notable trends in child health has been the increase in the number of children with special health care needs, including those with complex chronic conditions. Care of these children accounts for a growing fraction of health care resources. We examine recent developments in health care, especially with regard to medical transport and prehospital care, that have emerged to adapt to this remarkable demographic trend. One such development is the focus on care coordination, including the dissemination of the patient-centered medical home concept. In the prehospital setting, the need for greater coordination has catalyzed the development of the emergency information form. Training programs for prehospital providers now incorporate specific modules for children with complex conditions. Another notable trend is the shift to a family-centered model of care. We explore efforts toward regionalization of care, including the development of specialized pediatric transport teams, and conclude with recommendations for a research agenda. PMID:22315689

[General anaesthesia in ophthalmology (author's transl)].

PubMed

Weiss, V

1977-02-01

General anaesthesia is aimed at calming the patient in the praeanaesthetic period, creating good operating conditions and ensuring a quiet post-anaesthetic recovery. A praeanaesthetic examination is necessary and special attention has to be given to the age and condition of the patient. Existant other deseases have to be treated and the anaesthetic technic has to be properly adapted to the kind of surgery. Modern anaesthetic drugs normally provide for these requirements and in particular to prevent the occurrence of the oculocardiac reflex.

Adaptation of Selenastrum capricornutum (Chlorophyceae) to copper

USGS Publications Warehouse

Kuwabara, J.S.; Leland, H.V.

1986-01-01

Selenastrum capricornutum Printz, growing in a chemically defined medium, was used as a model for studying adaptation of algae to a toxic metal (copper) ion. Cells exhibited lag-phase adaptation to 0.8 ??M total Cu (10-12 M free ion concentration) after 20 generations of Cu exposure. Selenastrum adapted to the same concentration when Cu was gradually introduced over an 8-h period using a specially designed apparatus that provided a transient increase in exposure concentration. Cu adaptation was not attributable to media conditioning by algal exudates. Duration of lag phase was a more sensitive index of copper toxicity to Selenastrum that was growth rate or stationary-phase cell density under the experimental conditions used. Chemical speciation of the Cu dosing solution influenced the duration of lag phase even when media formulations were identical after dosing. Selenastrum initially exposed to Cu in a CuCl2 injection solution exhibited a lag phase of 3.9 d, but this was reduced to 1.5 d when a CuEDTA solution was used to achieve the same total Cu and EDTA concentrations. Physical and chemical processes that accelerated the rate of increase in cupric ion concentration generally increased the duration of lag phase. ?? 1986.

Microbial taxonomic diversity and adaptation mechanisms in lithic ecosystems of the northern Victoria Land, Antarctica

NASA Astrophysics Data System (ADS)

Kim, O. S.; Lee, J.; Cho, J. H.; Kwon, M.; Cho, A.; Kim, M.; Woo, J.; Hong, S. G.; Lee, J.

2016-12-01

Rock is one of the best habitat for microorganisms in Antarctica, providing the good condition to avoid strong sunlight and wind. Furthermore, geochemistry in rock can provide as nutrients for microorganisms. Barren rock can be considered as an ecosystem by fouling, which is defined as the settlement of organisms and their growth. These life forms have the specialized mechanism to adapt the harsh environmental conditions such as a below subzero temperature, a unique annual light/dark cycle, wind chill and limited water availability and nutrient supply. However, little is known about the microbial communities and their adaptation mechanisms in this harsh environments. In this study, we focus on the microbial ecology in order to understand what kind of microorganisms are present based on culture-dependent and -independent methods collected barren rock samples from the northern Victoria Land, Antarctica. Additionally, we present the complete genome sequence of Cryobacterium arcticum PAMC 27867, one of the isolates from these rock samples, in order to understand the microbial adaptation strategies in lithic ecosystems, Antarctica.

Detached Eddy Simulation of the UH-60 Rotor Wake Using Adaptive Mesh Refinement

NASA Technical Reports Server (NTRS)

Chaderjian, Neal M.; Ahmad, Jasim U.

2012-01-01

Time-dependent Navier-Stokes flow simulations have been carried out for a UH-60 rotor with simplified hub in forward flight and hover flight conditions. Flexible rotor blades and flight trim conditions are modeled and established by loosely coupling the OVERFLOW Computational Fluid Dynamics (CFD) code with the CAMRAD II helicopter comprehensive code. High order spatial differences, Adaptive Mesh Refinement (AMR), and Detached Eddy Simulation (DES) are used to obtain highly resolved vortex wakes, where the largest turbulent structures are captured. Special attention is directed towards ensuring the dual time accuracy is within the asymptotic range, and verifying the loose coupling convergence process using AMR. The AMR/DES simulation produced vortical worms for forward flight and hover conditions, similar to previous results obtained for the TRAM rotor in hover. AMR proved to be an efficient means to capture a rotor wake without a priori knowledge of the wake shape.

Convergent Metabolic Specialization through Distinct Evolutionary Paths in Pseudomonas aeruginosa.

PubMed

La Rosa, Ruggero; Johansen, Helle Krogh; Molin, Søren

2018-04-10

Evolution by natural selection under complex and dynamic environmental conditions occurs through intricate and often counterintuitive trajectories affecting many genes and metabolic solutions. To study short- and long-term evolution of bacteria in vivo , we used the natural model system of cystic fibrosis (CF) infection. In this work, we investigated how and through which trajectories evolution of Pseudomonas aeruginosa occurs when migrating from the environment to the airways of CF patients, and specifically, we determined reduction of growth rate and metabolic specialization as signatures of adaptive evolution. We show that central metabolic pathways of three distinct Pseudomonas aeruginosa lineages coevolving within the same environment become restructured at the cost of versatility during long-term colonization. Cell physiology changes from naive to adapted phenotypes resulted in (i) alteration of growth potential that particularly converged to a slow-growth phenotype, (ii) alteration of nutritional requirements due to auxotrophy, (iii) tailored preference for carbon source assimilation from CF sputum, (iv) reduced arginine and pyruvate fermentation processes, and (v) increased oxygen requirements. Interestingly, although convergence was evidenced at the phenotypic level of metabolic specialization, comparative genomics disclosed diverse mutational patterns underlying the different evolutionary trajectories. Therefore, distinct combinations of genetic and regulatory changes converge to common metabolic adaptive trajectories leading to within-host metabolic specialization. This study gives new insight into bacterial metabolic evolution during long-term colonization of a new environmental niche. IMPORTANCE Only a few examples of real-time evolutionary investigations in environments outside the laboratory are described in the scientific literature. Remembering that biological evolution, as it has progressed in nature, has not taken place in test tubes, it is not surprising that conclusions from our investigations of bacterial evolution in the CF model system are different from what has been concluded from laboratory experiments. The analysis presented here of the metabolic and regulatory driving forces leading to successful adaptation to a new environment provides an important insight into the role of metabolism and its regulatory mechanisms for successful adaptation of microorganisms in dynamic and complex environments. Understanding the trajectories of adaptation, as well as the mechanisms behind slow growth and rewiring of regulatory and metabolic networks, is a key element to understand the adaptive robustness and evolvability of bacteria in the process of increasing their in vivo fitness when conquering new territories. Copyright © 2018 La Rosa et al.

[Plastic surgery treatment techniques for interdisciplinary therapy of pressure sores].

PubMed

Müller, Karin; Becker, Frederic; Pfau, Matthias; Werdin, Frank

2017-06-01

Pressure sores in geriatric patients represent a challenge for all disciplines involved in the treatment process; however, the prerequisite for successful treatment is the elaboration of an interdisciplinary treatment concept. The treatment goals should be adapted to the individual needs of the patients including the life situation, general condition and local findings. In addition to general basic operative techniques, such as wound cleansing and conditioning, plastic and reconstructive surgery provides a wide range of highly specialized operative techniques for the treatment of these patients by which a definitive defect coverage can be achieved. The aim of this article is to raise awareness for these complex and highly specialized procedures for all disciplines participating in the treatment in order to improve the interdisciplinary cooperation and ultimately the quality of treatment.

Safe medication management in specialized home healthcare - an observational study.

PubMed

Lindblad, Marléne; Flink, Maria; Ekstedt, Mirjam

2017-08-24

Medication management is a complex, error-prone process. The aim of this study was to explore what constitutes the complexity of the medication management process (MMP) in specialized home healthcare and how healthcare professionals handle this complexity. The study is theoretically based in resilience engineering. Data were collected during the MMP at three specialized home healthcare units in Sweden using two strategies: observation of workplaces and shadowing RNs in everyday work, including interviews. Transcribed material was analysed using grounded theory. The MMP in home healthcare was dynamic and complex with unclear boundaries of responsibilities, inadequate information systems and fluctuating work conditions. Healthcare professionals adapted their everyday clinical work by sharing responsibility and simultaneously being authoritative and preserving patients' active participation, autonomy and integrity. To promote a safe MMP, healthcare professionals constantly re-prioritized goals, handled gaps in communication and information transmission at a distance by creating new bridging solutions. Trade-offs and workarounds were necessary elements, but also posed a threat to patient safety, as these interim solutions were not systematically evaluated or devised learning strategies. To manage a safe medication process in home healthcare, healthcare professionals need to adapt to fluctuating conditions and create bridging strategies through multiple parallel activities distributed over time, space and actors. The healthcare professionals' strategies could be integrated in continuous learning, while preserving boundaries of safety, instead of being more or less interim solutions. Patients' and family caregivers' as active partners in the MMP may be an underestimated resource for a resilient home healthcare.

Digital Storytelling in the Middle Childhood Special Education Classroom: A Teacher's Story of Adaptations

ERIC Educational Resources Information Center

Michalski, Paige; Hodges, Dodi; Banister, Savilla

2005-01-01

This article chronicles one special educator's process of implementing adaptive instructional strategies in her middle school language arts classroom. Paige Michalski crafted adaptations for her students with disabilities in the curricular area of digital storytelling (Banaszewski, 2002; Dunn, 2000). Digital storytelling involves telling stories…

38 CFR 36.4401 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

..., together with such movable or special fixtures and necessary adaptations as are authorized by 38 U.S.C... improvements thereon and which is in keeping with the locality; and special fixtures and necessary adaptations....S.C. chapter 21 and this subpart. (Authority: 38 U.S.C. 501, 2101) Temporary residence adaptations...

38 CFR 36.4401 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

..., together with such movable or special fixtures and necessary adaptations as are authorized by 38 U.S.C... improvements thereon and which is in keeping with the locality; and special fixtures and necessary adaptations....S.C. chapter 21 and this subpart. (Authority: 38 U.S.C. 501, 2101) Temporary residence adaptations...

38 CFR 36.4401 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

..., together with such movable or special fixtures and necessary adaptations as are authorized by 38 U.S.C... improvements thereon and which is in keeping with the locality; and special fixtures and necessary adaptations....S.C. chapter 21 and this subpart. (Authority: 38 U.S.C. 501, 2101) Temporary residence adaptations...

38 CFR 36.4401 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-07-01

..., together with such movable or special fixtures and necessary adaptations as are authorized by 38 U.S.C... improvements thereon and which is in keeping with the locality; and special fixtures and necessary adaptations....S.C. chapter 21 and this subpart. (Authority: 38 U.S.C. 501, 2101) Temporary residence adaptations...

Including "Everyone" in Outdoor Play.

ERIC Educational Resources Information Center

Flynn, Lynda L.; Kieff, Judith

2002-01-01

Presents guidelines for outdoor play that are important when young children have special needs. Details a decision-making process for planning adaptations and practical strategies for making adaptations and interventions to enhance outdoor play for children with special needs. Lists adaptations for a child who is blind, is deaf, has physical…

Rethinking the evolution of specialization: A model for the evolution of phenotypic heterogeneity.

PubMed

Rubin, Ilan N; Doebeli, Michael

2017-12-21

Phenotypic heterogeneity refers to genetically identical individuals that express different phenotypes, even when in the same environment. Traditionally, "bet-hedging" in fluctuating environments is offered as the explanation for the evolution of phenotypic heterogeneity. However, there are an increasing number of examples of microbial populations that display phenotypic heterogeneity in stable environments. Here we present an evolutionary model of phenotypic heterogeneity of microbial metabolism and a resultant theory for the evolution of phenotypic versus genetic specialization. We use two-dimensional adaptive dynamics to track the evolution of the population phenotype distribution of the expression of two metabolic processes with a concave trade-off. Rather than assume a Gaussian phenotype distribution, we use a Beta distribution that is capable of describing genotypes that manifest as individuals with two distinct phenotypes. Doing so, we find that environmental variation is not a necessary condition for the evolution of phenotypic heterogeneity, which can evolve as a form of specialization in a stable environment. There are two competing pressures driving the evolution of specialization: directional selection toward the evolution of phenotypic heterogeneity and disruptive selection toward genetically determined specialists. Because of the lack of a singular point in the two-dimensional adaptive dynamics and the fact that directional selection is a first order process, while disruptive selection is of second order, the evolution of phenotypic heterogeneity dominates and often precludes speciation. We find that branching, and therefore genetic specialization, occurs mainly under two conditions: the presence of a cost to maintaining a high phenotypic variance or when the effect of mutations is large. A cost to high phenotypic variance dampens the strength of selection toward phenotypic heterogeneity and, when sufficiently large, introduces a singular point into the evolutionary dynamics, effectively guaranteeing eventual branching. Large mutations allow the second order disruptive selection to dominate the first order selection toward phenotypic heterogeneity. Copyright © 2017 Elsevier Ltd. All rights reserved.

Pollinator Foraging Adaptation and Coexistence of Competing Plants.

PubMed

Revilla, Tomás A; Křivan, Vlastimil

2016-01-01

We use the optimal foraging theory to study coexistence between two plant species and a generalist pollinator. We compare conditions for plant coexistence for non-adaptive vs. adaptive pollinators that adjust their foraging strategy to maximize fitness. When pollinators have fixed preferences, we show that plant coexistence typically requires both weak competition between plants for resources (e.g., space or nutrients) and pollinator preferences that are not too biased in favour of either plant. We also show how plant coexistence is promoted by indirect facilitation via the pollinator. When pollinators are adaptive foragers, pollinator's diet maximizes pollinator's fitness measured as the per capita population growth rate. Simulations show that this has two conflicting consequences for plant coexistence. On the one hand, when competition between pollinators is weak, adaptation favours pollinator specialization on the more profitable plant which increases asymmetries in plant competition and makes their coexistence less likely. On the other hand, when competition between pollinators is strong, adaptation promotes generalism, which facilitates plant coexistence. In addition, adaptive foraging allows pollinators to survive sudden loss of the preferred plant host, thus preventing further collapse of the entire community.

An adaptive spoiler to control the transonic shock

NASA Astrophysics Data System (ADS)

Bein, Th; Hanselka, H.; Breitbach, E.

2000-04-01

Market research predicts, for the aircraft industry, a large growth in the number of passengers as well as the airfreight rate with the result of this leading to increased competition for the European aircraft industry, the efficiency of new aircraft has to be improved drastically. One approach, among others, is the aerodynamic optimization of the wing. The fixed wing is designed optimally only for one flight condition. This flight condition is described by the parameters altitude, mach number and aircraft weight, all of which permanently vary during the mission of the aircraft. Therefore, the aircraft is just periodically near to the chosen design point. To compensate for this major disadvantage, an `adaptive wing' for optimal adaptation and variation of the profile geometry to the actual flight conditions will be developed. Daimler-Benz Aerospace Airbus, Daimler-Benz Research and the German Aerospace Center (DLR) are working as project partners on concepts for a variable camber and a local spoiler bump. In this paper a structural concept developed by the DLR for the adaptive spoiler will be presented. The concept is designed under the aspect of adaptive structural systems and requires a high integration of actuators, sensor and controllers in the structure. Special aspects of the design will be discussed and the first results, analytical, numerical as well as experimental, will be presented. Part of the concept design is also the development of new actuators optimized for the specific problem. A new actuator concept for the adaptive spoiler based on a cylindrical tube and activated either by pressure or multifunctional materials (e.g. shape memory alloys) will additionally be shown.

Adaptive Fuzzy Tracking Control for a Class of MIMO Nonlinear Systems in Nonstrict-Feedback Form.

PubMed

Chen, Bing; Lin, Chong; Liu, Xiaoping; Liu, Kefu

2015-12-01

This paper focuses on the problem of fuzzy adaptive control for a class of multiinput and multioutput (MIMO) nonlinear systems in nonstrict-feedback form, which contains the strict-feedback form as a special case. By the condition of variable partition, a new fuzzy adaptive backstepping is proposed for such a class of nonlinear MIMO systems. The suggested fuzzy adaptive controller guarantees that the proposed control scheme can guarantee that all the signals in the closed-loop system are semi-globally uniformly ultimately bounded and the tracking errors eventually converge to a small neighborhood around the origin. The main advantage of this paper is that a control approach is systematically derived for nonlinear systems with strong interconnected terms which are the functions of all states of the whole system. Simulation results further illustrate the effectiveness of the suggested approach.

A test of the adaptive specialization hypothesis: population differences in caching, memory, and the hippocampus in black-capped chickadees (Poecile atricapilla).

PubMed

Pravosudov, Vladimir V; Clayton, Nicola S

2002-08-01

To test the hypothesis that accurate cache recovery is more critical for birds that live in harsh conditions where the food supply is limited and unpredictable, the authors compared food caching, memory, and the hippocampus of black-capped chickadees (Poecile atricapilla) from Alaska and Colorado. Under identical laboratory conditions, Alaska chickadees (a) cached significantly more food; (b) were more efficient at cache recovery: (c) performed more accurately on one-trial associative learning tasks in which birds had to rely on spatial memory, but did not differ when tested on a nonspatial version of this task; and (d) had significantly larger hippocampal volumes containing more neurons compared with Colorado chickadees. The results support the hypothesis that these population differences may reflect adaptations to a harsh environment.

Microalgae community shifts during the biogas upgrading in an alkaline open photobioreactor.

PubMed

Granada-Moreno, C I; Aburto-Medina, A; de Los Cobos Vasconcelos, D; González-Sánchez, A

2017-10-01

To achieve the functional specialization of a microalgae community through operational tuning of an open photobioreactor used for biogas upgrading under alkaline conditions. An open photobioreactor was inoculated with an indigenous microalgae sample from the Texcoco Soda Lake. A microalgae community was adapted to fix CO 2 from synthetic biogas through different culture conditions reaching a maximum of 220 mg CO 2  l -1 per day. Picochlorum sp. and Scenedesmus sp. were identified as the prominent microalgae genera by molecular fingerprinting (partial sequencing of 16S rRNA and 18S rRNA genes) but only the first was detected by microscopy screening. Changes in the microalgae community profile were monitored by a range-weighted richness index, reaching the lowest value when biogas was upgraded. A robust microalgae community in the open photobioreactor was obtained after different culture conditions. The specialization of microalgae community for CO 2 fixation under H 2 S presence was driven by biogas upgrading conditions. The alkaline conditions enhance the CO 2 absorption from biogas and could optimize specialized microalgae communities in the open photobioreactor. Denaturing gradient gel electrophoresis fingerprinting and richness index comparison are useful methods for the evaluation of microalgae community shifts and photosynthetic activity performance, particularly in systems intended for CO 2 removal from biogas where the CO 2 assimilation potential can be related to the microbial richness. © 2017 The Society for Applied Microbiology.

Adaptive Skills and Maladaptive Behavior of Adolescents with Autism Spectrum Disorders Attending Special Schools in Singapore

ERIC Educational Resources Information Center

Poon, Kenneth K.

2011-01-01

This study describes the profile of and relationships between adaptive skills and the maladaptive behaviors exhibited by adolescents with autism spectrum disorders (ASD) attending special schools in Singapore. Parents of 20 adolescents with ASD attending special schools completed the Development Behavior Checklist (DBC; Einfeld & Tonge, 1995;…

Phylogeny-based comparative methods question the adaptive nature of sporophytic specializations in mosses.

PubMed

Huttunen, Sanna; Olsson, Sanna; Buchbender, Volker; Enroth, Johannes; Hedenäs, Lars; Quandt, Dietmar

2012-01-01

Adaptive evolution has often been proposed to explain correlations between habitats and certain phenotypes. In mosses, a high frequency of species with specialized sporophytic traits in exposed or epiphytic habitats was, already 100 years ago, suggested as due to adaptation. We tested this hypothesis by contrasting phylogenetic and morphological data from two moss families, Neckeraceae and Lembophyllaceae, both of which show parallel shifts to a specialized morphology and to exposed epiphytic or epilithic habitats. Phylogeny-based tests for correlated evolution revealed that evolution of four sporophytic traits is correlated with a habitat shift. For three of them, evolutionary rates of dual character-state changes suggest that habitat shifts appear prior to changes in morphology. This suggests that they could have evolved as adaptations to new habitats. Regarding the fourth correlated trait the specialized morphology had already evolved before the habitat shift. In addition, several other specialized "epiphytic" traits show no correlation with a habitat shift. Besides adaptive diversification, other processes thus also affect the match between phenotype and environment. Several potential factors such as complex genetic and developmental pathways yielding the same phenotypes, differences in strength of selection, or constraints in phenotypic evolution may lead to an inability of phylogeny-based comparative methods to detect potential adaptations.

Youth Violence as Adaptation? Introduction to the Special Issue

ERIC Educational Resources Information Center

Swisher, Raymond R.; Latzman, Robert D.

2008-01-01

This article introduces the special issue of the journal on the topic of youth violence as adaptation to community violence. Contrary to the predominant perspective that youth violence is a sign of dysfunction or maladaptation, the articles collected here consider whether some youth violence may have positively adaptive consequences in the face of…

Polymeric Thin Films for Organic Electronics: Properties and Adaptive Structures

PubMed Central

Cataldo, Sebastiano; Pignataro, Bruno

2013-01-01

This review deals with the correlation between morphology, structure and performance of organic electronic devices including thin film transistors and solar cells. In particular, we report on solution processed devices going into the role of the 3D supramolecular organization in determining their electronic properties. A selection of case studies from recent literature are reviewed, relying on solution methods for organic thin-film deposition which allow fine control of the supramolecular aggregation of polymers confined at surfaces in nanoscopic layers. A special focus is given to issues exploiting morphological structures stemming from the intrinsic polymeric dynamic adaptation under non-equilibrium conditions. PMID:28809362

Specialized hybrid learners resolve Rogers' paradox about the adaptive value of social learning.

PubMed

Kharratzadeh, Milad; Montrey, Marcel; Metz, Alex; Shultz, Thomas R

2017-02-07

Culture is considered an evolutionary adaptation that enhances reproductive fitness. A common explanation is that social learning, the learning mechanism underlying cultural transmission, enhances mean fitness by avoiding the costs of individual learning. This explanation was famously contradicted by Rogers (1988), who used a simple mathematical model to show that cheap social learning can invade a population without raising its mean fitness. He concluded that some crucial factor remained unaccounted for, which would reverse this surprising result. Here we extend this model to include a more complex environment and limited resources, where individuals cannot reliably learn everything about the environment on their own. Under such conditions, cheap social learning evolves and enhances mean fitness, via hybrid learners capable of specializing their individual learning. We then show that while spatial or social constraints hinder the evolution of hybrid learners, a novel social learning strategy, complementary copying, can mitigate these effects. Copyright © 2016 Elsevier Ltd. All rights reserved.

Building Adaptive Expertise and Practice-Based Evidence: Applying the Implementation Stages Framework to Special Education Teacher Preparation

ERIC Educational Resources Information Center

Mason-Williams, Loretta; Frederick, Jacqueline R.; Mulcahy, Candace A.

2015-01-01

Preparing pre-service special educators to meet classroom demands requires teacher preparation programs to design experiences for students to demonstrate routine expertise, while also building adaptive expertise. In this article, the authors describe a capstone project that meets these needs and prepares pre-service special educators for their…

Oblique radiation lateral open boundary conditions for a regional climate atmospheric model

NASA Astrophysics Data System (ADS)

Cabos Narvaez, William; De Frutos Redondo, Jose Antonio; Perez Sanz, Juan Ignacio; Sein, Dmitry

2013-04-01

The prescription of lateral boundary conditions in regional atmospheric models represent a very important issue for limited area models. The ill-posed nature of the open boundary conditions makes it necessary to devise schemes in order to filter spurious wave reflections at boundaries, being desirable to have one boundary condition per variable. On the other side, due to the essentially hyperbolic nature of the equations solved in state of the art atmospheric models, external data is required only for inward boundary fluxes. These circumstances make radiation lateral boundary conditions a good choice for the filtering of spurious wave reflections. Here we apply the adaptive oblique radiation modification proposed by Mikoyada and Roseti to each of the prognostic variables of the REMO regional atmospheric model and compare it to the more common normal radiation condition used in REMO. In the proposed scheme, special attention is paid to the estimation of the radiation phase speed, essential to detecting the direction of boundary fluxes. One of the differences with the classical scheme is that in case of outward propagation, the adaptive nudging imposed in the boundaries allows to minimize under and over specifications problems, adequately incorporating the external information.

An Analysis of Social Skills Instruction Provided in Teacher Education and In-Service Training Programs for General and Special Educators

ERIC Educational Resources Information Center

Dobbins, Nicole; Higgins, Kyle; Pierce, Tom; Tandy, Richard D.; Tincani, Matt

2010-01-01

An adapted version of the "Teacher/Staff Skillstreaming Checklist" was used to determine the level, type, and area of social skills instruction provided to general and special education teachers. Nine universities participated in the study in which facilitators advertised the adapted questionnaire to licensed general and special education teachers…

Effects of an Adapted Physical Education Teaching Model on Special Educator Teaching Approaches for Students with Low Incidence Disabilities

ERIC Educational Resources Information Center

Laughlin, Michael K.

2013-01-01

The purpose of this study was to examine the effects of a training package, which consisted of the Flex Grid Teaching Model along with adapted physical education consultation, on special education teacher instruction of functional motor skill acquisition instruction to secondary students with low incidence disabilities. Special education teachers…

Introduction to the special section: sustainability of work with chronic health conditions.

PubMed

Shaw, William S; Tveito, Torill H; Boot, Cécile R L

2013-06-01

The increasing prevalence of older workers and chronic health conditions represents a growing occupational health concern. More research is needed to understand risk factors, apply and adapt theories, and test workplace-focused interventions that might prevent work disability and disengagement among chronically ill workers. A 2-h roundtable symposium involving 28 participants was held at an international conference (Second Scientific Conference on Work Disability Prevention & Integration, Groningen, The Netherlands) in October 2012. In that symposium, small groups of participants were invited to discuss theoretical, methodological, and implementation considerations for studying workplace function and well-being among workers with chronic health conditions. As a follow-up to the symposium, the organizers invited authors to submit original articles to a Special Section of the Journal of Occupational Rehabilitation for peer review and publication. Results of the symposium reflected the need to address social, not just physical, aspects of the workplace, to include both individual-level and organizational interventions, and to integrate employer perspectives and operational models. Contributions to the Special Issue focus on outcome measurement, symptom self-management at work, job accommodations, prognostic factors for disability escalation, and the perceived needs of affected workers. The content of the Special Section reflects an evolving body of research that continues to grapple with basic issues around choice of outcome measures, level of intervention, and the optimal ways to meet the needs of workers with chronic health conditions, including supporting efforts to manage symptoms and function at work. Future research should focus on integrating organizational and individual-level interventions.

UTCI-Fiala multi-node model of human heat transfer and temperature regulation

NASA Astrophysics Data System (ADS)

Fiala, Dusan; Havenith, George; Bröde, Peter; Kampmann, Bernhard; Jendritzky, Gerd

2012-05-01

The UTCI-Fiala mathematical model of human temperature regulation forms the basis of the new Universal Thermal Climate Index (UTC). Following extensive validation tests, adaptations and extensions, such as the inclusion of an adaptive clothing model, the model was used to predict human temperature and regulatory responses for combinations of the prevailing outdoor climate conditions. This paper provides an overview of the underlying algorithms and methods that constitute the multi-node dynamic UTCI-Fiala model of human thermal physiology and comfort. Treated topics include modelling heat and mass transfer within the body, numerical techniques, modelling environmental heat exchanges, thermoregulatory reactions of the central nervous system, and perceptual responses. Other contributions of this special issue describe the validation of the UTCI-Fiala model against measured data and the development of the adaptive clothing model for outdoor climates.

Conditional statistical inference with multistage testing designs.

PubMed

Zwitser, Robert J; Maris, Gunter

2015-03-01

In this paper it is demonstrated how statistical inference from multistage test designs can be made based on the conditional likelihood. Special attention is given to parameter estimation, as well as the evaluation of model fit. Two reasons are provided why the fit of simple measurement models is expected to be better in adaptive designs, compared to linear designs: more parameters are available for the same number of observations; and undesirable response behavior, like slipping and guessing, might be avoided owing to a better match between item difficulty and examinee proficiency. The results are illustrated with simulated data, as well as with real data.

Environmental change makes robust ecological networks fragile

USGS Publications Warehouse

Strona, Giovanni; Lafferty, Kevin D.

2016-01-01

Complex ecological networks appear robust to primary extinctions, possibly due to consumers’ tendency to specialize on dependable (available and persistent) resources. However, modifications to the conditions under which the network has evolved might alter resource dependability. Here, we ask whether adaptation to historical conditions can increase community robustness, and whether such robustness can protect communities from collapse when conditions change. Using artificial life simulations, we first evolved digital consumer-resource networks that we subsequently subjected to rapid environmental change. We then investigated how empirical host–parasite networks would respond to historical, random and expected extinction sequences. In both the cases, networks were far more robust to historical conditions than new ones, suggesting that new environmental challenges, as expected under global change, might collapse otherwise robust natural ecosystems.

Modeling, Control, and Estimation of Flexible, Aerodynamic Structures

NASA Astrophysics Data System (ADS)

Ray, Cody W.

Engineers have long been inspired by nature’s flyers. Such animals navigate complex environments gracefully and efficiently by using a variety of evolutionary adaptations for high-performance flight. Biologists have discovered a variety of sensory adaptations that provide flow state feedback and allow flying animals to feel their way through flight. A specialized skeletal wing structure and plethora of robust, adaptable sensory systems together allow nature’s flyers to adapt to myriad flight conditions and regimes. In this work, motivated by biology and the successes of bio-inspired, engineered aerial vehicles, linear quadratic control of a flexible, morphing wing design is investigated, helping to pave the way for truly autonomous, mission-adaptive craft. The proposed control algorithm is demonstrated to morph a wing into desired positions. Furthermore, motivated specifically by the sensory adaptations organisms possess, this work transitions to an investigation of aircraft wing load identification using structural response as measured by distributed sensors. A novel, recursive estimation algorithm is utilized to recursively solve the inverse problem of load identification, providing both wing structural and aerodynamic states for use in a feedback control, mission-adaptive framework. The recursive load identification algorithm is demonstrated to provide accurate load estimate in both simulation and experiment.

Issues in development, evaluation, and use of the NASA Preflight Adaptation Trainer (PAT)

NASA Technical Reports Server (NTRS)

Lane, Norman E.; Kennedy, Robert S.

1988-01-01

The Preflight Adaptation Trainer (PAT) is intended to reduce or alleviate space adaptation syndrome by providing opportunities for portions of that adaptation to occur under normal gravity conditions prior to space flight. Since the adaptation aspects of the PAT objectives involve modification not only of the behavior of the trainee, but also of sensiomotor skills which underly the behavioral generation, the defining of training objectives of the PAT utilizes four mechanisms: familiarization, demonstration, training and adaptation. These mechanisms serve as structural reference points for evaluation, drive the content and organization of the training procedures, and help to define the roles of the PAT instructors and operators. It was determined that three psychomotor properties are most critical for PAT evaluation: reliability; sensitivity; and relevance. It is cause for concern that the number of measures available to examine PAT effects exceed those that can be properly studied with the available sample sizes; special attention will be required in selection of the candidate measure set. The issues in PAT use and application within a training system context are addressed through linking the three training related mechanisms of familiarization, demonstration and training to the fourth mechanism, adaptation.

Pollinator Foraging Adaptation and Coexistence of Competing Plants

PubMed Central

Revilla, Tomás A.; Křivan, Vlastimil

2016-01-01

We use the optimal foraging theory to study coexistence between two plant species and a generalist pollinator. We compare conditions for plant coexistence for non-adaptive vs. adaptive pollinators that adjust their foraging strategy to maximize fitness. When pollinators have fixed preferences, we show that plant coexistence typically requires both weak competition between plants for resources (e.g., space or nutrients) and pollinator preferences that are not too biased in favour of either plant. We also show how plant coexistence is promoted by indirect facilitation via the pollinator. When pollinators are adaptive foragers, pollinator’s diet maximizes pollinator’s fitness measured as the per capita population growth rate. Simulations show that this has two conflicting consequences for plant coexistence. On the one hand, when competition between pollinators is weak, adaptation favours pollinator specialization on the more profitable plant which increases asymmetries in plant competition and makes their coexistence less likely. On the other hand, when competition between pollinators is strong, adaptation promotes generalism, which facilitates plant coexistence. In addition, adaptive foraging allows pollinators to survive sudden loss of the preferred plant host, thus preventing further collapse of the entire community. PMID:27505254

Considering the Specific Impact of Harsh Conditions and Oil Weathering on Diversity, Adaptation, and Activity of Hydrocarbon-Degrading Bacteria in Strategies of Bioremediation of Harsh Oily-Polluted Soils.

PubMed

Al Disi, Zulfa; Jaoua, Samir; Al-Thani, Dhabia; Al-Meer, Saeed; Zouari, Nabil

2017-01-01

Weathering processes change properties and composition of spilled oil, representing the main reason of failure of bioaugmentation strategies. Our purpose was to investigate the metabolic adaptation of hydrocarbon-degrading bacteria at harsh conditions to be considered to overcome the limitations of bioaugmentation strategies at harsh conditions. Polluted soils, exposed for prolonged periods to weathered oil in harsh soils and weather conditions, were used. Two types of enrichment cultures were employed using 5% and 10% oil or diesel as sole carbon sources with varying the mineral nitrogen sources and C/N ratios. The most effective isolates were obtained based on growth, tolerance to toxicity, and removal efficiency of diesel hydrocarbons. Activities of the newly isolated bacteria, in relation to the microenvironment from where they were isoalted and their interaction with the weathered oil, showed individual specific ability to adapt when exposed to such factors, to acquire metabolic potentialities. Among 39 isolates, ten identified ones by 16S rDNA genes similarities, including special two Pseudomonas isolates and one Citrobacter isolate, showed particularity of shifting hydrocarbon-degrading ability from short chain n -alkanes ( n -C12- n -C16) to longer chain n -alkanes ( n -C21- n -C25) and vice versa by alternating nitrogen source compositions and C/N ratios. This is shown for the first time.

Understanding the Threat Ecosystem: A Concept for Intelligence Support to Special Warfare

DTIC Science & Technology

2016-05-10

international law, national law, behavioral norms and ethical principles have no restraining effects on them.5 This emerging complexity paradigm is one...similar to a biome: a major ecological community of organisms adapted to a particular climatic or environmental condition on a large geographic area in...Awareness through tracking agents and agency in the threat environment is paramount to building an accurate ecological frame of the operational environment

Neuro-Triggered Training.

DTIC Science & Technology

1992-04-30

Avnalabiliy Co~e ’Dst Special The views and conclusions in this document am those of the aunots and should not be intepreted as necesnuily repesenmg the...accuracy and the adaptive error tolerance. We have set up a small new recording room for this project and cleared it of 60-Hz electromagnetic noise...stimuli sounded alike. In the semantic condition, subjects were required to decide if the high frequency, open-class monosyllabic words were opposite or not

A note on the special fillet fatty acid composition of the dwarf carp (Cyprinus carpio carpio) living in thermal Lake Hévíz, Hungary.

PubMed

Varga, D; Müller, T; Specziár, A; Fébel, H; Hancz, Cs; Bázár, Gy; Urbányi, B; Szabó, A

2013-03-01

Fatty acid (FA) composition of the fillet and the intestinal content of dwarf common carp (Cyprinus carpio carpio) living in Lake Hévíz was determined in wintertime collected samples and results were compared to widespread literature data on carp. Fillet FA profile of the thermally adapted (28 °C) Hévíz dwarf carps differed from profiles originated from divergent culture and feeding conditions in the overall level of saturation. Fillet myristic acid proportions largely exceeded all literature data in spite of poor dietary supply. Fillet fatty acid results indicate the effects of thermal adaptation (high saturation level) and the correlative effects of feed components rich in omega-3 fatty acids, with special respect to docosahexaenoic acid. With the application of discriminant factor analysis the Hévíz sample was accurately differentiated from the literature data on carp fillet fatty acid profile, mostly based on C14:0, C18:1 n9, C18:2 n6, C20:1 n9 and C20:4 n6 FAs. In summary, fillet FA profile suggested thermal adaptation, location specificity and the ingestion of algal and bacterial material.

Square tracking sensor for autonomous helicopter hover stabilization

NASA Astrophysics Data System (ADS)

Oertel, Carl-Henrik

1995-06-01

Sensors for synthetic vision are needed to extend the mission profiles of helicopters. A special task for various applications is the autonomous position hold of a helicopter above a ground fixed or moving target. As a proof of concept for a general synthetic vision solution a restricted machine vision system, which is capable of locating and tracking a special target, was developed by the Institute of Flight Mechanics of Deutsche Forschungsanstalt fur Luft- und Raumfahrt e.V. (i.e., German Aerospace Research Establishment). This sensor, which is specialized to detect and track a square, was integrated in the fly-by-wire helicopter ATTHeS (i.e., Advanced Technology Testing Helicopter System). An existing model following controller for the forward flight condition was adapted for the hover and low speed requirements of the flight vehicle. The special target, a black square with a length of one meter, was mounted on top of a car. Flight tests demonstrated the automatic stabilization of the helicopter above the moving car by synthetic vision.

Report on ESA Topical Team on the Large Radius Human Centrifuge: "The Human Hypergravity Habitat; H3"

NASA Astrophysics Data System (ADS)

van Loon, Jack J. W. A.; Bücker, N.; Berte, J.; Bok, K.; Bos, J.; Boyle, R.; Bravenoer, N.; Chouker, A.; Clement, G.; Cras, P.; Denise, D.; Eekhoff, M.; Felsenberg, D.; Fong, K.; Fuller, C.; Groen, E.; Heer, M.; Hinghofer-Szalkay, H.; Iwase, S.; Karemaker, J. M.; Linnarsson, D.; Lüthen, C.; Narici, M.; Norsk, P.; Paloski, W.; Rutten, M.; Saggini, R.; Stephan, A.; Ullrich, O.; Vautmans, V.; Wuyts, F.; Young, L.

Over the last decades a significant amount of knowledge has been accumulated on the adap-tation of the human body going into near weightless conditions and on its re-adaptation to 1g Earth conditions after space flight. Ground-based paradigms for microgravity simulation have been developed such as head down tilted bed rest and dry-immersion. In such systems the adaptations to long term immobilization and to head-ward fluid shifts have been studied. Questions we address here are: can long-term ground-based centrifugation help us to under-stand and even predict the adaptations to long-term increased gravity conditions? How does the body adapt to chronic (days, weeks or longer) exposure to a hypergravity environment? And, once the body has fully adapted to a hypergravity environment, how does it re-adapt going from a hypergravity state back to a relatively hypo-gravity condition of 1g, or even going from a centrifuge / hypergravity environment into a bed-rest setting? Can such transitions in well-controlled studies bring us closer to understanding the consequences of gravity transitions that the crews will likely experience going to the Moon or to Mars. Is hypergravity a good model to study the effect of re-entry in gravitational environments after long duration space flight? In an ESA -supported Topical Team we address all organ systems known so far to change directly or indirectly by altered gravity conditions. We will identify to which gravity levels the human body can be exposed for longer periods of time and what protocols could be applied to address the questions at hand. We also identify the technology required to ac-complish such long duration hypergravity and re-adaptation studies. Issues like ethics, safety and required logistics should be addressed. As there is limited experience with exposure of hu-man test subjects to prolonged periods of moderately increased g-forces, unexpected harm may occur. Therefore, the information, disclosure and informed consent procedures need special attention. The final outcome of the Topical Team will be a clear answer about the feasibility of the use of hypergravity as a tool and analogue for space research, and if and how hypergravity studies can provide useful knowledge to support future space flight on the one hand and current medical issues in the ageing population (osteoporosis, cardiovascular diseases, obesity) on the other hand.

[Radiation-induced genomic instability: phenomenon, molecular mechanisms, pathogenetic significance].

PubMed

Mazurik, V K; Mikhaĭlov, V F

2001-01-01

The recent data on the radiation-induced genome instability as a special state of progeny of cells irradiated in vitro as well as after a whole body exposure to ionizing radiation, that make these cells considerably different from normal, unirradiated cells, were considered. This state presents a number of cytogenetical, molecular-biological, cytological and biochemical manifestations untypical for normal cells. The state is controlled by the mechanisms of regulation of checkpoints of cell cycle, and apoptosis, that is under gene p53 control. The proof has been found that this state transfers from irradiated maternal cells to their surviving progeny by the epigenetical mechanisms and would exist until the cells restore the original state of response on the DNA damage. From the point of view of the genome instability conception, that considers the chromatine rearrangement as the adaptive-evolution mechanism of adaptation of the species to changeable environmental conditions, the radiation-induced genome instability may be considered as transition of irradiated progeny to the state of read these to adaptation changes with two alternative pathways. The first leads to adaptation to enviromental conditions and restoring of normal cell functions. The second presents the cell transition into the transformed state with remain genome instability and with increase of tumour growth probability.

Special Physical Education: Adapted, Individualized, Developmental. Seventh Edition.

ERIC Educational Resources Information Center

Dunn, John M.

This text on physical education for children and adolescents with disabilities attempts to bring together current research findings and best educational practices from the fields of adapted physical education, special education, psychology, medicine, physical therapy, occupational therapy, and therapeutic recreation. The book is organized into…

Greenlandic Inuit show genetic signatures of diet and climate adaptation.

PubMed

Fumagalli, Matteo; Moltke, Ida; Grarup, Niels; Racimo, Fernando; Bjerregaard, Peter; Jørgensen, Marit E; Korneliussen, Thorfinn S; Gerbault, Pascale; Skotte, Line; Linneberg, Allan; Christensen, Cramer; Brandslund, Ivan; Jørgensen, Torben; Huerta-Sánchez, Emilia; Schmidt, Erik B; Pedersen, Oluf; Hansen, Torben; Albrechtsen, Anders; Nielsen, Rasmus

2015-09-18

The indigenous people of Greenland, the Inuit, have lived for a long time in the extreme conditions of the Arctic, including low annual temperatures, and with a specialized diet rich in protein and fatty acids, particularly omega-3 polyunsaturated fatty acids (PUFAs). A scan of Inuit genomes for signatures of adaptation revealed signals at several loci, with the strongest signal located in a cluster of fatty acid desaturases that determine PUFA levels. The selected alleles are associated with multiple metabolic and anthropometric phenotypes and have large effect sizes for weight and height, with the effect on height replicated in Europeans. By analyzing membrane lipids, we found that the selected alleles modulate fatty acid composition, which may affect the regulation of growth hormones. Thus, the Inuit have genetic and physiological adaptations to a diet rich in PUFAs. Copyright © 2015, American Association for the Advancement of Science.

Physiologic and behavioral effects of papoose board on anxiety in dental patients with special needs.

PubMed

Chen, Hsin-Yung; Yang, Hsiang; Chi, Huang-Ju; Chen, Hsin-Ming

2014-02-01

Anxiety induced by dental treatment can become a serious problem, especially for patients with special needs. Application of deep touch pressure, which is a sensory adaptation technique, may ameliorate anxiety in disabled patients. However, few empiric studies have investigated the possible links between the clinical effects of deep touch pressure and its behavioral and physiologic aspects. Equally little progress has been made concerning theoretical development. The current study is a crossover intervention trial to investigate the behavioral and physiological effects of deep touch pressure for participants receiving dental treatment. Nineteen disabled participants, who were retrospectively subclassified for positive trend or negative trend, were recruited to receive the papoose board as an application of deep touch pressure. Quantitative analyses of behavioral assessments and physiological measurements, including electrodermal activity and heart rate variability, were conducted. We sought to understand the modulation of the autonomic nervous system and the orchestration of sympathetic and parasympathetic (PsNS) nervous systems. Behavioral assessments reported that higher levels of anxiety were induced by the dental treatment for participants with both groups of positive and negative trends. Although no significant differences were found in the SNS activity, physiologic responses indicated that significantly changes of PsNS activity were observed under the stress condition (dental treatment) when deep touch pressure intervention was applied, especially for participants in the group of positive trend. Our results suggest that the PsNS activation plays a critical role in the process of ANS modulation. This study provides not only physiologic evidence for the modulation effects of deep touch pressure on stressful conditions in dental environments but also the evidence that the application of papoose board, as a sensory adaptation technique, is not harmful for dental patients with special needs. Copyright © 2012. Published by Elsevier B.V.

Effectiveness of a computerised working memory training in adolescents with mild to borderline intellectual disabilities.

PubMed

Van der Molen, M J; Van Luit, J E H; Van der Molen, M W; Klugkist, I; Jongmans, M J

2010-05-01

The goal of this study is to evaluate the effectiveness of a computerised working memory (WM) training on memory, response inhibition, fluid intelligence, scholastic abilities and the recall of stories in adolescents with mild to borderline intellectual disabilities attending special education. A total of 95 adolescents with mild to borderline intellectual disabilities were randomly assigned to either a training adaptive to each child's progress in WM, a non-adaptive WM training, or to a control group. Verbal short-term memory (STM) improved significantly from pre- to post-testing in the group who received the adaptive training compared with the control group. The beneficial effect on verbal STM was maintained at follow-up and other effects became clear at that time as well. Both the adaptive and non-adaptive WM training led to higher scores at follow-up than at post-intervention on visual STM, arithmetic and story recall compared with the control condition. In addition, the non-adaptive training group showed a significant increase in visuo-spatial WM capacity. The current study provides the first demonstration that WM can be effectively trained in adolescents with mild to borderline intellectual disabilities.

The eyes of lanternfishes (Myctophidae, Teleostei): novel ocular specializations for vision in dim light.

PubMed

de Busserolles, Fanny; Marshall, N Justin; Collin, Shaun P

2014-05-01

Lanternfishes are one of the most abundant groups of mesopelagic fishes in the world's oceans and play a critical role in biomass vertical turnover. Despite their importance, very little is known about their physiology or how they use their sensory systems to survive in the extreme conditions of the deep sea. In this study, we provide a comprehensive description of the general morphology of the myctophid eye, based on analysis of 53 different species, to understand better their visual capabilities. Results confirm that myctophids possess several visual adaptations for dim-light conditions, including enlarged eyes, an aphakic gap, a tapetum lucidum, and a pure rod retina with high densities of long photoreceptors. Two novel retinal specializations were also discovered. The first specialization is a fundal pigmentation in adult eyes, found within an isolated retinal region (typically central retina) composed of modified pigment epithelial cells, which we hypothesize to be the remnant of a more pronounced visual specialization important in larval stages. The second specialization is an aggregation of extracellular microtubular-like structures found within the sclerad region of the inner nuclear layer of the retina. We hypothesize that the marked interspecific differences in the hypertrophy of these microtubular-like structures may be related to inherent differences in visual function. A general interspecific variability in other parts of the eye is also revealed and examined in this study. The contribution of both ecology and phylogeny to the evolution of ocular specializations and vision in dim light are discussed. Copyright © 2013 Wiley Periodicals, Inc.

Adaptive Physical Education: Instructional Module for Special Education Minors.

ERIC Educational Resources Information Center

Smyser, Sheryl; And Others

This module is designed to familiarize students preparing to be special education teachers with the physical needs of the exceptional student. Information is given on how to structure an adaptive physical education program designed to meet those needs, including development of an individualized education program (IEP). The module covers such…

Environmental change makes robust ecological networks fragile

PubMed Central

Strona, Giovanni; Lafferty, Kevin D.

2016-01-01

Complex ecological networks appear robust to primary extinctions, possibly due to consumers' tendency to specialize on dependable (available and persistent) resources. However, modifications to the conditions under which the network has evolved might alter resource dependability. Here, we ask whether adaptation to historical conditions can increase community robustness, and whether such robustness can protect communities from collapse when conditions change. Using artificial life simulations, we first evolved digital consumer-resource networks that we subsequently subjected to rapid environmental change. We then investigated how empirical host–parasite networks would respond to historical, random and expected extinction sequences. In both the cases, networks were far more robust to historical conditions than new ones, suggesting that new environmental challenges, as expected under global change, might collapse otherwise robust natural ecosystems. PMID:27511722

Cold climate specialization: adaptive covariation between metabolic rate and thermoregulation in pregnant vipers.

PubMed

Lourdais, Olivier; Guillon, Michaël; Denardo, Dale; Blouin-Demers, Gabriel

2013-07-02

We compared thermoregulatory strategies during pregnancy in two congeneric viperid snakes (Vipera berus and Vipera aspis) with parapatric geographic ranges. V. berus is a boreal specialist with the largest known distribution among terrestrial snakes while V. aspis is a south-European species. Despite contrasted climatic affinities, the two species displayed identical thermal preferences (Tset) in a laboratory thermal gradient. Under identical natural conditions, however, V. berus was capable of maintaining Tset for longer periods, especially when the weather was constraining. Consistent with the metabolic cold adaptation hypothesis, V. berus displayed higher standard metabolic rate at all temperatures considered. We used the thermal dependence of metabolic rate to calculate daily metabolic profiles from body temperature under natural conditions. The boreal specialist experienced higher daily metabolic rate and minimized gestation duration chiefly because of differences in the metabolic reaction norms, but also superior thermoregulatory efficiency. Under cold climates, thermal constraints should make precise thermoregulation costly. However, a shift in the metabolic reaction norm may compensate for thermal constraints and modify the cost-benefit balance of thermoregulation. Covariation between metabolic rate and thermoregulation efficiency is likely an important adaptation to cold climates. Copyright © 2013 Elsevier Inc. All rights reserved.

Characterizing the reproductive transcriptomic correlates of acute dehydration in males in the desert-adapted rodent, Peromyscus eremicus.

PubMed

Kordonowy, Lauren; MacManes, Matthew

2017-06-23

The understanding of genomic and physiological mechanisms related to how organisms living in extreme environments survive and reproduce is an outstanding question facing evolutionary and organismal biologists. One interesting example of adaptation is related to the survival of mammals in deserts, where extreme water limitation is common. Research on desert rodent adaptations has focused predominantly on adaptations related to surviving dehydration, while potential reproductive physiology adaptations for acute and chronic dehydration have been relatively neglected. This study aims to explore the reproductive consequences of acute dehydration by utilizing RNAseq data in the desert-specialized cactus mouse (Peromyscus eremicus). We exposed 22 male cactus mice to either acute dehydration or control (fully hydrated) treatment conditions, quasimapped testes-derived reads to a cactus mouse testes transcriptome, and then evaluated patterns of differential transcript and gene expression. Following statistical evaluation with multiple analytical pipelines, nine genes were consistently differentially expressed between the hydrated and dehydrated mice. We hypothesized that male cactus mice would exhibit minimal reproductive responses to dehydration; therefore, this low number of differentially expressed genes between treatments aligns with current perceptions of this species' extreme desert specialization. However, these differentially expressed genes include Insulin-like 3 (Insl3), a regulator of male fertility and testes descent, as well as the solute carriers Slc45a3 and Slc38a5, which are membrane transport proteins that may facilitate osmoregulation. These results suggest that in male cactus mice, acute dehydration may be linked to reproductive modulation via Insl3, but not through gene expression differences in the subset of other a priori tested reproductive hormones. Although water availability is a reproductive cue in desert-rodents exposed to chronic drought, potential reproductive modification via Insl3 in response to acute water-limitation is a result which is unexpected in an animal capable of surviving and successfully reproducing year-round without available external water sources. Indeed, this work highlights the critical need for integrative research that examines every facet of organismal adaptation, particularly in light of global climate change, which is predicted, amongst other things, to increase climate variability, thereby exposing desert animals more frequently to the acute drought conditions explored here.

Genome and Transcriptome Analyses Provide Insight into the Euryhaline Adaptation Mechanism of Crassostrea gigas

PubMed Central

Zhang, Linlin; Li, Chunyan; Li, Li; She, Zhicai; Huang, Baoyu; Zhang, Guofan

2013-01-01

Background The Pacific oyster, Crassostrea gigas, has developed special mechanisms to regulate its osmotic balance to adapt to fluctuations of salinities in coastal zones. To understand the oyster’s euryhaline adaptation, we analyzed salt stress effectors metabolism pathways under different salinities (salt 5, 10, 15, 20, 25, 30 and 40 for 7 days) using transcriptome data, physiology experiment and quantitative real-time PCR. Results Transcriptome data uncovered 189, 480, 207 and 80 marker genes for monitoring physiology status of oysters and the environment conditions. Three known salt stress effectors (involving ion channels, aquaporins and free amino acids) were examined. The analysis of ion channels and aquaporins indicated that 7 days long-term salt stress inhibited voltage-gated Na+/K+ channel and aquaporin but increased calcium-activated K+ channel and Ca2+ channel. As the most important category of osmotic stress effector, we analyzed the oyster FAAs metabolism pathways (including taurine, glycine, alanine, beta-alanine, proline and arginine) and explained FAAs functional mechanism for oyster low salinity adaptation. FAAs metabolism key enzyme genes displayed expression differentiation in low salinity adapted individuals comparing with control which further indicated that FAAs played important roles for oyster salinity adaptation. A global metabolic pathway analysis (iPath) of oyster expanded genes displayed a co-expansion of FAAs metabolism in C. gigas compared with seven other species, suggesting oyster’s powerful ability regarding FAAs metabolism, allowing it to adapt to fluctuating salinities, which may be one important mechanism underlying euryhaline adaption in oyster. Additionally, using transcriptome data analysis, we uncovered salt stress transduction networks in C. gigas. Conclusions Our results represented oyster salt stress effectors functional mechanisms under salt stress conditions and explained the expansion of FAAs metabolism pathways as the most important effectors for oyster euryhaline adaptation. This study was the first to explain oyster euryhaline adaptation at a genome-wide scale in C. gigas. PMID:23554902

Considering the Specific Impact of Harsh Conditions and Oil Weathering on Diversity, Adaptation, and Activity of Hydrocarbon-Degrading Bacteria in Strategies of Bioremediation of Harsh Oily-Polluted Soils

PubMed Central

Al Disi, Zulfa; Jaoua, Samir; Al-Thani, Dhabia; Al-Meer, Saeed

2017-01-01

Weathering processes change properties and composition of spilled oil, representing the main reason of failure of bioaugmentation strategies. Our purpose was to investigate the metabolic adaptation of hydrocarbon-degrading bacteria at harsh conditions to be considered to overcome the limitations of bioaugmentation strategies at harsh conditions. Polluted soils, exposed for prolonged periods to weathered oil in harsh soils and weather conditions, were used. Two types of enrichment cultures were employed using 5% and 10% oil or diesel as sole carbon sources with varying the mineral nitrogen sources and C/N ratios. The most effective isolates were obtained based on growth, tolerance to toxicity, and removal efficiency of diesel hydrocarbons. Activities of the newly isolated bacteria, in relation to the microenvironment from where they were isoalted and their interaction with the weathered oil, showed individual specific ability to adapt when exposed to such factors, to acquire metabolic potentialities. Among 39 isolates, ten identified ones by 16S rDNA genes similarities, including special two Pseudomonas isolates and one Citrobacter isolate, showed particularity of shifting hydrocarbon-degrading ability from short chain n-alkanes (n-C12–n-C16) to longer chain n-alkanes (n-C21–n-C25) and vice versa by alternating nitrogen source compositions and C/N ratios. This is shown for the first time. PMID:28243605

Adaptive Physical Education and Aquatics for Students with Disabilities: A Teacher's Unique Experience

ERIC Educational Resources Information Center

Blassingame, Jennifer Cheryl

2011-01-01

Students with the most severe disabilities have special needs that cannot be addressed with general education curriculum modifications in a traditional prekindergarten-12th grade environment (Heward, 2006). It is essential that expert teachers with specialized educational background and training are prepared to adapt daily lessons to accommodate…

75 FR 68669 - Loan Guaranty: Assistance to Eligible Individuals in Acquiring Specially Adapted Housing; Cost-of...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-08

... Specially Adapted Housing; Cost-of-Construction Index AGENCY: Department of Veterans Affairs. ACTION: Notice... SAH assistance annually based on a residential home cost-of-construction index. The Secretary uses the Turner Building Cost Index for this purpose. During the most recent calendar year for which the Turner...

Adapting and Modifying Toys for Children with Special Needs.

ERIC Educational Resources Information Center

Simpson, Cynthia G.; Lynch, Sharon A.

Many caregivers doubt their ability to provide appropriate play experiences for children with special needs included in their program because some children with disabilities may not have the ability to interact and manipulate toys in a meaningful way. This paper provides guidance in appropriately adapting toys and the play situation to allow many…

Comparing service use and costs among adolescents with autism spectrum disorders, special needs and typical development.

PubMed

Barrett, Barbara; Mosweu, Iris; Jones, Catherine Rg; Charman, Tony; Baird, Gillian; Simonoff, Emily; Pickles, Andrew; Happé, Francesca; Byford, Sarah

2015-07-01

Autism spectrum disorder is a complex condition that requires specialised care. Knowledge of the costs of autism spectrum disorder, especially in comparison with other conditions, may be useful to galvanise policymakers and leverage investment in education and intervention to mitigate aspects of autism spectrum disorder that negatively impact individuals with the disorder and their families. This article describes the services and associated costs for four groups of individuals: adolescents with autistic disorder, adolescents with other autism spectrum disorders, adolescents with other special educational needs and typically developing adolescents using data from a large, well-characterised cohort assessed as part of the UK Special Needs and Autism Project at the age of 12 years. Average total costs per participant over 6 months were highest in the autistic disorder group (£11,029), followed by the special educational needs group (£9268), the broader autism spectrum disorder group (£8968) and the typically developing group (£2954). Specialised day or residential schooling accounted for the vast majority of costs. In regression analysis, lower age and lower adaptive functioning were associated with higher costs in the groups with an autism spectrum disorder. Sex, ethnicity, number of International Classification of Diseases (10th revision) symptoms, autism spectrum disorder symptom scores and levels of mental health difficulties were not associated with cost. © The Author(s) 2014.

Map Learning with a 3D Printed Interactive Small-Scale Model: Improvement of Space and Text Memorization in Visually Impaired Students.

PubMed

Giraud, Stéphanie; Brock, Anke M; Macé, Marc J-M; Jouffrais, Christophe

2017-01-01

Special education teachers for visually impaired students rely on tools such as raised-line maps (RLMs) to teach spatial knowledge. These tools do not fully and adequately meet the needs of the teachers because they are long to produce, expensive, and not versatile enough to provide rapid updating of the content. For instance, the same RLM can barely be used during different lessons. In addition, those maps do not provide any interactivity, which reduces students' autonomy. With the emergence of 3D printing and low-cost microcontrollers, it is now easy to design affordable interactive small-scale models (SSMs) which are adapted to the needs of special education teachers. However, no study has previously been conducted to evaluate non-visual learning using interactive SSMs. In collaboration with a specialized teacher, we designed a SSM and a RLM representing the evolution of the geography and history of a fictitious kingdom. The two conditions were compared in a study with 24 visually impaired students regarding the memorization of the spatial layout and historical contents. The study showed that the interactive SSM improved both space and text memorization as compared to the RLM with braille legend. In conclusion, we argue that affordable home-made interactive small scale models can improve learning for visually impaired students. Interestingly, they are adaptable to any teaching situation including students with specific needs.

Dietary Specialization during the Evolution of Western Eurasian Hominoids and the Extinction of European Great Apes

PubMed Central

DeMiguel, Daniel; Alba, David M.; Moyà-Solà, Salvador

2014-01-01

Given the central adaptive role of diet, paleodietary inference is essential for understanding the relationship between evolutionary and paleoenvironmental change. Here we rely on dental microwear analysis to investigate the role of dietary specialization in the diversification and extinction of Miocene hominoids from Western Eurasian between 14 and 7 Ma. New microwear results for five extinct taxa are analyzed together with previous data for other Western Eurasian genera. Except Pierolapithecus (that resembles hard-object feeders) and Oreopithecus (a soft-frugivore probably foraging opportunistically on other foods), most of the extinct taxa lack clear extant dietary analogues. They display some degee of sclerocarpy, which is most clearly expressed in Griphopithecus and Ouranopithecus (adapted to more open and arid environments), whereas Anoiapithecus, Dryopithecus and, especially, Hispanopithecus species apparently relied more strongly on soft-frugivory. Thus, contrasting with the prevailing sclerocarpic condition at the beginning of the Eurasian hominoid radiation, soft- and mixed-frugivory coexisted with hard-object feeding in the Late Miocene. Therefore, despite a climatic trend towards cooling and increased seasonality, a progressive dietary diversification would have occurred (probably due to competitive exclusion and increased environmental heterogeneity), although strict folivory did not evolve. Overall, our analyses support the view that the same dietary specializations that enabled Western Eurasian hominoids to face progressive climatic deterioration were the main factor ultimately leading to their extinction when more drastic paleoenvironmental changes took place. PMID:24848272

Novel approaches to pin cluster synchronization on complex dynamical networks in Lur'e forms

NASA Astrophysics Data System (ADS)

Tang, Ze; Park, Ju H.; Feng, Jianwen

2018-04-01

This paper investigates the cluster synchronization of complex dynamical networks consisted of identical or nonidentical Lur'e systems. Due to the special topology structure of the complex networks and the existence of stochastic perturbations, a kind of randomly occurring pinning controller is designed which not only synchronizes all Lur'e systems in the same cluster but also decreases the negative influence among different clusters. Firstly, based on an extended integral inequality, the convex combination theorem and S-procedure, the conditions for cluster synchronization of identical Lur'e networks are derived in a convex domain. Secondly, randomly occurring adaptive pinning controllers with two independent Bernoulli stochastic variables are designed and then sufficient conditions are obtained for the cluster synchronization on complex networks consisted of nonidentical Lur'e systems. In addition, suitable control gains for successful cluster synchronization of nonidentical Lur'e networks are acquired by designing some adaptive updating laws. Finally, we present two numerical examples to demonstrate the validity of the control scheme and the theoretical analysis.

Design of a shape adaptive airfoil actuated by a Shape Memory Alloy strip for airplane tail

NASA Astrophysics Data System (ADS)

Shirzadeh, R.; Raissi Charmacani, K.; Tabesh, M.

2011-04-01

Of the factors that mainly affect the efficiency of the wing during a special flow regime, the shape of its airfoil cross section is the most significant. Airfoils are generally designed for a specific flight condition and, therefore, are not fully optimized in all flight conditions. It is very desirable to have an airfoil with the ability to change its shape based on the current regime. Shape memory alloy (SMA) actuators activate in response to changes in the temperature and can recover their original configuration after being deformed. This study presents the development of a method to control the shape of an airfoil using SMA actuators. To predict the thermomechanical behaviors of an SMA thin strip, 3D incremental formulation of the SMA constitutive model is implemented in FEA software package ABAQUS. The interactions between the airfoil structure and SMA thin strip actuator are investigated. Also, the aerodynamic performance of a standard airfoil with a plain flap is compared with an adaptive airfoil.

COVD-QOL questionnaire: An adaptation for school vision screening using Rasch analysis

PubMed Central

Abu Bakar, Nurul Farhana; Ai Hong, Chen; Pik Pin, Goh

2012-01-01

Purpose To adapt the College of Optometrist in Vision Development (COVD-QOL) questionnaire as a vision screening tool for primary school children. Methods An interview session was conducted with children, teachers or guardians regarding visual symptoms of 88 children (45 from special education classes and 43 from mainstream classes) in government primary schools. Data was assessed for response categories, fit items (infit/outfit: 0.6–1.4) and separation reliability (item/person: 0.80). The COVD-QOL questionnaire results were compared with vision assessment in identifying three categories of vision disorders: reduce visual acuity, accommodative response anomaly and convergence insufficiency. Analysis on the screening performance using the simplified version of the questionnaire was evaluated based on receiver-operating characteristic analysis for detection of any type of target conditions for both types of classes. Predictive validity analysis was used a Spearman rank correlation (>0.3). Results Two of the response categories were underutilized and therefore collapsed to the adjacent category and items were reduced to 14. Item separation reliability for the simplified version of the questionnaire was acceptable (0.86) but the person separation reliability was inadequate for special education classes (0.79) similar to mainstream classes (0.78). The discriminant cut-off score of 9 (mainstream classes) and 3 (special education classes) from the 14 items provided sensitivity and specificity of (65% and 54%) and (78% and 80%) with Spearman rank correlation of 0.16 and 0.40 respectively. Conclusion The simplified version of COVD-QOL questionnaire (14-items) performs adequately among children in special education classes suggesting its suitability as a vision screening tool.

Plant Chemistry and Local Adaptation of a Specialized Folivore

PubMed Central

Laukkanen, Liisa; Leimu, Roosa; Muola, Anne; Lilley, Marianna; Salminen, Juha-Pekka; Mutikainen, Pia

2012-01-01

Local adaptation is central for creating and maintaining spatial variation in plant-herbivore interactions. Short-lived insect herbivores feeding on long-lived plants are likely to adapt to their local host plants, because of their short generation time, poor dispersal, and geographically varying selection due to variation in plant defences. In a reciprocal feeding trial, we investigated the impact of geographic variation in plant secondary chemistry of a long-lived plant, Vincetoxicum hirundinaria, on among-population variation in local adaptation of a specialist leaf-feeding herbivore, Abrostola asclepiadis. The occurrence and degree of local adaptation varied among populations. This variation correlated with qualitative and quantitative differences in plant chemistry among the plant populations. These findings provide insights into the mechanisms driving variation in local adaptation in this specialized plant-herbivore interaction. PMID:22666493

78 FR 61002 - Loan Guaranty: Assistance to Eligible Individuals in Acquiring Specially Adapted Housing; Cost-of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-02

... Specially Adapted Housing; Cost-of-Construction Index AGENCY: Department of Veterans Affairs. ACTION: Notice... index. The Secretary uses the Turner Building Cost Index for this purpose. In the most recent quarter for which the Turner Building Cost Index is available, Quarter 2 FY 2013, the index showed an increase...

Adapting Self-Regulated Strategy Development in Persuasive Writing for Adolescents Who Are Deaf or Hard of Hearing

ERIC Educational Resources Information Center

Vostal, Brooks R.; Ward, Megan S.

2015-01-01

Within the special education community, research and policy focus on teachers implementing evidence-based instructional practices with fidelity. However, special education teachers may have to adapt evidence-based practices if the research supporting those practices has not yet included studies that represent populations in the classrooms (i.e.,…

Immigrants' adaptation to different cultural settings: A contextual perspective on acculturation: Introduction for the special section on immigration.

PubMed

Titzmann, Peter F; Fuligni, Andrew J

2015-12-01

In modern multicultural societies more and more individuals deal with 2 or more cultures due to the unprecedented increase in international migration. This special section brings together research about immigrants' adaptation to various life domains, about the demands of dealing with different cultural scripts and about how immigrants can successfully bridge different cultural demands. This introduction to the special section provides a broader theoretical framework that links the different studies of the special section and demonstrates areas for further research. It also clearly illustrates the growing necessity for research in increasingly diverse societies. © 2015 International Union of Psychological Science.

Adaptive evolution of Mediterranean pines.

PubMed

Grivet, Delphine; Climent, José; Zabal-Aguirre, Mario; Neale, David B; Vendramin, Giovanni G; González-Martínez, Santiago C

2013-09-01

Mediterranean pines represent an extremely heterogeneous assembly. Although they have evolved under similar environmental conditions, they diversified long ago, ca. 10 Mya, and present distinct biogeographic and demographic histories. Therefore, it is of special interest to understand whether and to what extent they have developed specific strategies of adaptive evolution through time and space. To explore evolutionary patterns, the Mediterranean pines' phylogeny was first reconstructed analyzing a new set of 21 low-copy nuclear genes with multilocus Bayesian tree reconstruction methods. Secondly, a phylogenetic approach was used to search for footprints of natural selection and to examine the evolution of multiple phenotypic traits. We identified two genes (involved in pines' defense and stress responses) that have likely played a role in the adaptation of Mediterranean pines to their environment. Moreover, few life-history traits showed historical or evolutionary adaptive convergence in Mediterranean lineages, while patterns of character evolution revealed various evolutionary trade-offs linking growth-development, reproduction and fire-related traits. Assessing the evolutionary path of important life-history traits, as well as the genomic basis of adaptive variation is central to understanding the past evolutionary success of Mediterranean pines and their future response to environmental changes. Copyright © 2013 Elsevier Inc. All rights reserved.

Phenotypic plasticity and specialization in clonal versus non-clonal plants: A data synthesis

NASA Astrophysics Data System (ADS)

Fazlioglu, Fatih; Bonser, Stephen P.

2016-11-01

Reproductive strategies can be associated with ecological specialization and generalization. Clonal plants produce lineages adapted to the maternal habitat that can lead to specialization. However, clonal plants frequently display high phenotypic plasticity (e.g. clonal foraging for resources), factors linked to ecological generalization. Alternately, sexual reproduction can be associated with generalization via increasing genetic variation or specialization through rapid adaptive evolution. Moreover, specializing to high or low quality habitats can determine how phenotypic plasticity is expressed in plants. The specialization hypothesis predicts that specialization to good environments results in high performance trait plasticity and specialization to bad environments results in low performance trait plasticity. The interplay between reproductive strategies, phenotypic plasticity, and ecological specialization is important for understanding how plants adapt to variable environments. However, we currently have a poor understanding of these relationships. In this study, we addressed following questions: 1) Is there a relationship between phenotypic plasticity, specialization, and reproductive strategies in plants? 2) Do good habitat specialists express greater performance trait plasticity than bad habitat specialists? We searched the literature for studies examining plasticity for performance traits and functional traits in clonal and non-clonal plant species from different habitat types. We found that non-clonal (obligate sexual) plants expressed greater performance trait plasticity and functional trait plasticity than clonal plants. That is, non-clonal plants exhibited a specialist strategy where they perform well only in a limited range of habitats. Clonal plants expressed less performance loss across habitats and a more generalist strategy. In addition, specialization to good habitats did not result in greater performance trait plasticity. This result was contrary to the predictions of the specialization hypothesis. Overall, reproductive strategies are associated with ecological specialization or generalization through phenotypic plasticity. While specialization is common in plant populations, the evolution of specialization does not control the nature of phenotypic plasticity as predicted under the specialization hypothesis.

Adapting diagrams from physics textbooks: improving the autonomy of blind students

NASA Astrophysics Data System (ADS)

Dickman, Adriana; Martins, Alexandre; Ferreira, Amauri

2014-03-01

In this work we elaborate and test a glossary consisting of a set of objects and their symbols. The symbols are designed to represent objects frequently used in mechanics diagrams, such as vectors, ropes, pulleys, blocks and surfaces, and can be used to adapt drawings of physics situations in textbooks for blind high school students. The educational product was tested at a specialized school for the blind. The results indicate that adequate training can help blind students to become familiar with the symbols, and to identify them in a problem without the need of a description. This educational product can help blind students to achieve the same conditions of autonomy as sighted ones, when studying physics. Research supported by CNPq, Capes, Fapemig and FIP/PUC-MG (Brazil).

Adapting diagrams from physics textbooks: a way to improve the autonomy of blind students

NASA Astrophysics Data System (ADS)

Dickman, A. G.; Martins, A. O.; Ferreira, A. C.; Andrade, L. M.

2014-09-01

We devise and test a set of tactile symbols to represent elements frequently used in mechanics diagrams, such as vectors, ropes, pulleys, blocks and surfaces, that can be used to adapt drawings of physics situations in textbooks for blind students. We also investigate how figures are described for blind students in classroom activities and exams, by interviewing three blind students using the oral history method. The symbols were tested at a specialized school for the blind. Our results indicate that, with training, blind students become familiar with the symbols and can identify them in a problem without the need for a spoken description. This educational product can help blind students to achieve the same conditions of autonomy as sighted ones when studying physics.

A Polarized Electron RF Photoinjector Using the Plane-Wave-Transformer (PWT) Design

DOE Office of Scientific and Technical Information (OSTI.GOV)

Clendenin, James E

Polarized electron beams are now in routine use in particle accelerators for nuclear and high energy physics experiments. These beams are presently produced by dc-biased photoelectron sources combined with rf chopping and bunching systems with inherently high transverse emittances. Low emittances can be produced with an rf gun, but the vacuum environment has until now been considered too harsh to support a negative electron affinity GaAs photocathode. We propose to significantly improve the vacuum conditions by adapting a PWT rf photoinjector to achieve reasonable cathode emission rates and lifetimes. This adaptation can also be combined with special optics that willmore » result in a flat beam with a normalized rms emittance in the narrow dimension that may be as low as 10{sup -8} m.« less

Prolonged exposure to salt stress affects specialized metabolites-artemisinin and essential oil accumulation in Artemisia annua L.: metabolic acclimation in preferential favour of enhanced terpenoid accumulation accompanying vegetative to reproductive phase transition.

PubMed

Yadav, Ritesh Kumar; Sangwan, Rajender Singh; Srivastava, Avadesh K; Sangwan, Neelam S

2017-01-01

Artemisia annua accumulates substantial quantities of unique and highly useful antimalarial sesquiternoid artemisinin and related phytomolecules as well as its characteristic essential oil in its glandular trichomes. The phytomolecules are mainly produced in its leaves and inflorescences. Artemisia annua plants were grown under NaCl salinity (50, 100 and 200 mM) stress conditions imposed throughout the entire life cycle of the plant. Results revealed that specialized metabolites like artemisinin, arteannuin-B, artemisinic acid + dihydroartemisinic acid and essential oil accumulation were positively modulated by NaCl salinity stress. Interestingly, total content of monoterpenoids and sesquiterpenoids of essential oil was induced by NaCl salinity treatment, contrary to previous observations. Production of camphor, the major essential oil constituent was induced under the influence of treatment. The metabolic acclimation and manifestations specific to terpenoid pathway are analysed vis-a-vis vegetative to reproductive periods and control of the modulation. WRKY and CYP71AV1 play a key role in mediating the responses through metabolism in glandular trichomes. The distinctness of the salinity induced responses is discussed in light of differential mechanism of adaptation to abiotic stresses and their impact on terpenoid-specific metabolic adjustments in A. annua. Results provide potential indications of possible adaptation of A. annua under saline conditions for agrarian techno-economic benefaction.

High Accuracy Temperature Measurements Using RTDs with Current Loop Conditioning

NASA Technical Reports Server (NTRS)

Hill, Gerald M.

1997-01-01

To measure temperatures with a greater degree of accuracy than is possible with thermocouples, RTDs (Resistive Temperature Detectors) are typically used. Calibration standards use specialized high precision RTD probes with accuracies approaching 0.001 F. These are extremely delicate devices, and far too costly to be used in test facility instrumentation. Less costly sensors which are designed for aeronautical wind tunnel testing are available and can be readily adapted to probes, rakes, and test rigs. With proper signal conditioning of the sensor, temperature accuracies of 0.1 F is obtainable. For reasons that will be explored in this paper, the Anderson current loop is the preferred method used for signal conditioning. This scheme has been used in NASA Lewis Research Center's 9 x 15 Low Speed Wind Tunnel, and is detailed.

Influence of material coupling and assembly condition on the magnitude of micromotion at the stem-neck interface of a modular hip endoprosthesis.

PubMed

Jauch, S Y; Huber, G; Hoenig, E; Baxmann, M; Grupp, T M; Morlock, M M

2011-06-03

Hip prostheses with a modular neck exhibit, compared to monobloc prostheses, an additional interface which bears the risk of fretting as well as corrosion. Failures at the neck adapter of modular prostheses have been observed for a number of different designs. It has been speculated that micromotions at the stem-neck interface were responsible for these implant failures. The purpose of this study was to investigate the influence of material combinations and assembly conditions on the magnitude of micromotions at the stem-neck interface during cyclic loading. Modular (n = 24) and monobloc (n = 3) hip prostheses of a similar design (Metha, Aesculap AG, Tuttlingen, Germany) were subjected to mechanical testing according to ISO 7206-4 (F(min) = 230N, F(max) = 2300N, f = 1Hz, n = 10,000 cycles). The neck adapters (Ti-6Al-4V or Co-Cr29-Mo alloy) were assembled with a clean or contaminated interface. The micromotion between stem and neck adapter was calculated at five reference points based on the measurements of the three eddy current sensors. The largest micromotions were observed at the lateral edge of the stem-neck taper connection, which is in accordance with the crack location of clinically failed prostheses. Titanium neck adapters showed significantly larger micromotions than cobalt-chromium neck adapters (p = 0.005). Contaminated interfaces also exhibited significantly larger micromotions (p < 0.001). Since excessive micromotions at the stem-neck interface might be involved in the process of implant failure, special care should be taken to clean the interface prior to assembly and titanium neck adapters with titanium stems should generally be used with caution. Copyright © 2011 Elsevier Ltd. All rights reserved.

Adaptive Optimization of Aircraft Engine Performance Using Neural Networks

NASA Technical Reports Server (NTRS)

Simon, Donald L.; Long, Theresa W.

1995-01-01

Preliminary results are presented on the development of an adaptive neural network based control algorithm to enhance aircraft engine performance. This work builds upon a previous National Aeronautics and Space Administration (NASA) effort known as Performance Seeking Control (PSC). PSC is an adaptive control algorithm which contains a model of the aircraft's propulsion system which is updated on-line to match the operation of the aircraft's actual propulsion system. Information from the on-line model is used to adapt the control system during flight to allow optimal operation of the aircraft's propulsion system (inlet, engine, and nozzle) to improve aircraft engine performance without compromising reliability or operability. Performance Seeking Control has been shown to yield reductions in fuel flow, increases in thrust, and reductions in engine fan turbine inlet temperature. The neural network based adaptive control, like PSC, will contain a model of the propulsion system which will be used to calculate optimal control commands on-line. Hopes are that it will be able to provide some additional benefits above and beyond those of PSC. The PSC algorithm is computationally intensive, it is valid only at near steady-state flight conditions, and it has no way to adapt or learn on-line. These issues are being addressed in the development of the optimal neural controller. Specialized neural network processing hardware is being developed to run the software, the algorithm will be valid at steady-state and transient conditions, and will take advantage of the on-line learning capability of neural networks. Future plans include testing the neural network software and hardware prototype against an aircraft engine simulation. In this paper, the proposed neural network software and hardware is described and preliminary neural network training results are presented.

Evidence-Based Practice in Special Education and Cultural Adaptations: Challenges and Implications for Research

ERIC Educational Resources Information Center

Wang, Mian; Lam, Yeana

2017-01-01

Many issues arise in the discussion of the evidence-based practice (EBP) movement and implementation science in special education and specific educational practices for students with severe disabilities. Yet cultural adaptations of EBPs, which have emerged as an area of research in other fields, are being left out as a focus of EBP discourse. The…

Jack-of-all-trades master of all? Snake vertebrae have a generalist inner organization

NASA Astrophysics Data System (ADS)

Houssaye, Alexandra; Boistel, Renaud; Böhme, Wolfgang; Herrel, Anthony

2013-11-01

Snakes are a very speciose group of squamates that adapted to various habitats and ecological niches. Their ecological diversity is of particular interest and functional demands associated with their various styles of locomotion are expected to result in anatomical specializations. In order to explore the potential adaptation of snakes to their environment we here analyze variation in vertebral structure at the microanatomical level in species with different locomotor adaptations. Vertebrae, being a major element of the snake body, are expected to display adaptations to the physical constraints associated with the different locomotor modes and environments. Our results revealed a rather homogenous vertebral microanatomy in contrast to what has been observed for other squamates and amniotes more generally. We here suggest that the near-absence of microanatomical specializations in snake vertebrae might be correlated to their rather homogeneous overall morphology and reduced range of morphological diversity, as compared to lizards. Thus, snakes appear to retain a generalist inner morphology that allows them to move efficiently in different environments. Only a few ecologically highly specialized taxa appear to display some microanatomical specializations that remain to be studied in greater detail.

Adaptive Management of Environmental Flows

NASA Astrophysics Data System (ADS)

Webb, J. Angus; Watts, Robyn J.; Allan, Catherine; Conallin, John C.

2018-03-01

Adaptive management enables managers to work with complexity and uncertainty, and to respond to changing biophysical and social conditions. Amid considerable uncertainty over the benefits of environmental flows, governments are embracing adaptive management as a means to inform decision making. This Special Issue of Environmental Management presents examples of adaptive management of environmental flows and addresses claims that there are few examples of its successful implementation. It arose from a session at the 11th International Symposium on Ecohydraulics held in Australia, and is consequently dominated by papers from Australia. We classified the papers according to the involvement of researchers, managers and the local community in adaptive management. Five papers report on approaches developed by researchers, and one paper on a community-led program; these case studies currently have little impact on decision making. Six papers provide examples involving water managers and researchers, and two papers provide examples involving water managers and the local community. There are no papers where researchers, managers and local communities all contribute equally to adaptive management. Successful adaptive management of environmental flows occurs more often than is perceived. The final paper explores why successes are rarely reported, suggesting a lack of emphasis on reflection on management practices. One major challenge is to increase the documentation of successful adaptive management, so that benefits of learning extend beyond the project where it takes place. Finally, moving towards greater involvement of all stakeholders is critical if we are to realize the benefits of adaptive management for improving outcomes from environmental flows.

"Vulnerability, Resiliency, and Adaptation: The Health of Latin Americans during the Migration Process to the United States"

PubMed

Riosmena, Fernando; Jochem, Warren C

2012-01-01

In this paper, we offer a general outlook of the health of Latin Americans (with a special emphasis on Mexicans) during the different stages of the migration process to the U.S. given the usefulness of the social vulnerability concept and given that said vulnerability varies conspicuously across the different stages of the migration process. Severe migrant vulnerability during the transit and crossing has serious negative health consequences. Yet, upon their arrival to the U.S., migrant health is favorable in outcomes such as mortality by many causes of death and in several chronic conditions and risk factors, though these apparent advantages seem to disappear during the process of adaptation to the host society. We discuss potential explanations for the initial health advantage and the sources of vulnerability that explain its erosion, with special emphasis in systematic timely access to health care. Given that migration can affect social vulnerability processes in sending areas, we discuss the potential health consequences for these places and conclude by considering the immigration and health policy implications of these issues for the United States and sending countries, with emphasis on Mexico.

“Vulnerability, Resiliency, and Adaptation: The Health of Latin Americans during the Migration Process to the United States”*

PubMed Central

Riosmena, Fernando; Jochem, Warren C.

2013-01-01

In this paper, we offer a general outlook of the health of Latin Americans (with a special emphasis on Mexicans) during the different stages of the migration process to the U.S. given the usefulness of the social vulnerability concept and given that said vulnerability varies conspicuously across the different stages of the migration process. Severe migrant vulnerability during the transit and crossing has serious negative health consequences. Yet, upon their arrival to the U.S., migrant health is favorable in outcomes such as mortality by many causes of death and in several chronic conditions and risk factors, though these apparent advantages seem to disappear during the process of adaptation to the host society. We discuss potential explanations for the initial health advantage and the sources of vulnerability that explain its erosion, with special emphasis in systematic timely access to health care. Given that migration can affect social vulnerability processes in sending areas, we discuss the potential health consequences for these places and conclude by considering the immigration and health policy implications of these issues for the United States and sending countries, with emphasis on Mexico. PMID:24660053

Using the New Scenarios Framework to Inform Climate Change Adaptation Policy in Finland

NASA Astrophysics Data System (ADS)

Carter, T. R.

2013-12-01

In 2005, Finland was among the first countries in the world to develop a national climate change adaptation strategy (Marttila et al., 2005). This included a characterization of future changes in climate and socioeconomic conditions using scenarios based on the IPCC Special Report on Emissions Scenarios (SRES - IPCC, 2000). Following a government evaluation of the strategy, completion of a national adaptation research programme, and in light of the recent European Union adaptation strategy, the Finnish strategy is now under revision. As part of this revision process, the New Scenario Framework (Moss et al., 2010) is being used to guide the mapping of future conditions in Finland out to the end of the 21st century. Future Finnish climate is being analysed using the CMIP5 climate model simulations (Taylor et al., 2012), including downscaled information based on regional climate model projections in the EURO-CORDEX project (Vautard et al., 2013). All projections are forced by the Representative Concentration Pathways (RCPs - van Vuuren et al., 2011). Socioeconomic scenarios are also being developed by outlining alternative pathways that reflect national social, economic, environmental and planning goals. These are designed according to the Shared Socioeconomic Pathway (SSP) framework of challenges to adaptation and mitigation (Kriegler et al., 2012). Work is in progress to characterize these pathways, mainly qualitatively, for different sectors in Finland. Preliminary results of the conceptual scenario development phase will be presented in this session. These initial ideas will be exchanged with representatives of ministries, regional government and key stakeholder groups. The eventual form and number of scenarios that appear in the revised strategy will be determined following a formal review of the draft document to be prepared in 2014. Future work could include quantification of scenarios, possibly mapping them onto the specific SSP worlds. This would then provide a firm basis for future climate change impact, adaptation and vulnerability assessments, offering RCP/SSP-based scenarios that are not only related to the global New Scenarios Framework, but are also recognised by national policy makers and key stakeholders, via the revised national climate change adaptation strategy. References IPCC (2000) Special Report on Emissions Scenarios: A Special Report of Working Group III of the Intergovernmental Panel on Climate Change. [Nakićenović, N. et al. (eds.)]. Cambridge University Press, 600 pp. Kriegler E et al. (2012) The need for and use of socio-economic scenarios for climate change analysis: A new approach based on shared socio-economic pathways. Glob. Envir. Change 22:807-822. Marttila V et al. (2005) Finland's National Strategy for Adaptation to Climate Change, MMM publications 1a/2005, Ministry of Agriculture and Forestry, Helsinki, Finland, 280 pp. Moss RH et al. (2010) The next generation of scenarios for climate change research and assessment. Nature 463:747-756. Taylor KE et al. (2012) A summary of the CMIP5 experiment design. BAMS 93:485-498. van Vuuren DP et al. (2011) The representative concentration pathways: an overview. Clim. Change 109:5-31. Vautard R et al. (2013) The simulation of European heat waves from an ensemble of regional climate models within the EURO-CORDEX project. Clim. Dyn. doi:10.1007/s00382-013-1714-z

Use of multiple regression models in the study of sandhopper orientation under natural conditions

NASA Astrophysics Data System (ADS)

Marchetti, Giovanni M.; Scapini, Felicita

2003-10-01

In sandhoppers (Amphipoda; Talitridae), typical dwellers of the supralittoral zone of sandy beaches, orientation with respect to the sun and landscape vision is adapted to the local direction of the shoreline. Variation of this behavioural adaptation can be related to the characteristics of the beach. Measures of orientation with respect to the shoreline direction can thus be made as a tool to assess beach stability versus changeability, once the sources of variation are correctly interpreted. Orientation of animals can be studied by statistical analysis of directions taken after release in nature. In this paper some new tools for exploring directional data are reviewed, with special emphasis on non-parametric smoothers and regression models. Results from a large study concerning one species of sandhoppers, Talitrus saltator (Montagu), from an exposed sandy beach in northeastern Tunisia are presented. Seasonal differences in orientation behaviour were shown with a higher scatter in autumn with respect to spring. The higher scatter shown in autumn depended both on intrinsic (sex) and external (climatic conditions and landscape visibility) factors and was related to the tendency of this species to migrate towards the dune anticipating winter conditions.

Software-centric View on OVMS for LBT

NASA Astrophysics Data System (ADS)

Trowitzsch, J.; Borelli, J.; Pott, J.; Kürster, M.

2012-09-01

The performance of infrared interferometry (IF) and adaptive optics (AO) strongly depends on the mitigation and correction of telescope vibrations. Therefore, at the Large Binocular Telescope (LBT) the OVMS, the Optical Path Difference and Vibration Monitoring System, is being installed. It is meant to ensure suitable conditions for adaptive optics and interferometry. The vibration information is collected from accelerometers that are distributed over the optical elements of the LBT. The collected vibration measurements are converted into tip-tilt and optical path difference data. That data is utilized in the control strategies of the LBT adaptive secondary mirrors and the beam combining interferometers, LINC-NIRVANA and LBTI. Within the OVMS the software part is responsibility of the LINC-NIRVANA team at MPIA Heidelberg. It comprises the software for the real-time data acquisition from the accelerometers as well as the related telemetry interface and the vibration monitoring quick look tools. The basic design ideas, implementation details and special features are explained here.

Changing Roles of Special Education Administrators: Impact on Multicultural Learners

ERIC Educational Resources Information Center

Bakken, Jeffrey P.; O'Brian, Mary; Shelden, Debra L.

2006-01-01

It is imperative for special education administrators, and all administrators, to adapt to the changing demographic and educational environments. The field of special education has changed dramatically in the last three decades, and administrators can and should be leaders of the continued evolution of special education. One useful organizing…

A Rural Special Education Teacher Training Program: Successful Adaptations.

ERIC Educational Resources Information Center

Prater, Greg; And Others

The Rural Special Education Program (RSEP), a partnership between Northern Arizona University (NAU) and Kayenta Unified School District (KUSD), provides training for preservice special education teachers to work with Native American students and their families. To date, the program has provided training for 63 preservice special education…

Comparison of Rooting Strategies to Explore Rock Fractures for Shallow Soil-Adapted Tree Species with Contrasting Aboveground Growth Rates: A Greenhouse Microcosm Experiment.

PubMed

Nie, Yunpeng; Chen, Hongsong; Ding, Yali; Yang, Jing; Wang, Kelin

2017-01-01

For tree species adapted to shallow soil environments, rooting strategies that efficiently explore rock fractures are important because soil water depletion occurs frequently. However, two questions: (a) to what extent shallow soil-adapted species rely on exploring rock fractures and (b) what outcomes result from drought stress, have rarely been tested. Therefore, based on the expectation that early development of roots into deep soil layers is at the cost of aboveground growth, seedlings of three tree species ( Cyclobalanopsis glauca, Delavaya toxocarpa , and Acer cinnamomifolium ) with distinct aboveground growth rates were selected from a typical shallow soil region. In a greenhouse experiment that mimics the basic features of shallow soil environments, 1-year-old seedlings were transplanted into simulated microcosms of shallow soil overlaying fractured bedrock. Root biomass allocation and leaf physiological activities, as well as leaf δ 13 C values were investigated and compared for two treatments: regular irrigation and repeated cycles of drought stress. Our results show that the three species differed in their rooting strategies in the context of encountering rock fractures, however, these strategies were not closely related to the aboveground growth rate. For the slowest-growing seedling, C. glauca , percentages of root mass in the fractures, as well as in the soil layer between soil and bedrock increased significantly under both treatments, indicating a specialized rooting strategy that facilitated the exploration of rock fractures. Early investment in deep root growth was likely critical to the establishment of this drought-vulnerable species. For the intermediate-growing, A. cinnamomifolium , percentages of root mass in the bedrock and interface soil layers were relatively low and exhibited no obvious change under either treatment. This limited need to explore rock fractures was compensated by a conservative water use strategy. For the fast-growing, D. toxocarpa , percentages of root mass in the bedrock and interface layers increased simultaneously under drought conditions, but not under irrigated conditions. This drought-induced rooting plasticity was associated with drought avoidance by this species. Although, root development might have been affected by the simulated microcosm, contrasting results among the three species indicated that efficient use of rock fractures is not a necessary or specialized strategy of shallow-soil adapted species. The establishment and persistence of these species relied on the mutual complementation between their species-specific rooting strategies and drought adaptations.

Diversification and intensification of agricultural adaptation from global to local scales.

PubMed

Chen, Minjie; Wichmann, Bruno; Luckert, Marty; Winowiecki, Leigh; Förch, Wiebke; Läderach, Peter

2018-01-01

Smallholder farming systems are vulnerable to a number of challenges, including continued population growth, urbanization, income disparities, land degradation, decreasing farm size and productivity, all of which are compounded by uncertainty of climatic patterns. Understanding determinants of smallholder farming practices is critical for designing and implementing successful interventions, including climate change adaptation programs. We examine two dimensions wherein smallholder farmers may adapt agricultural practices; through intensification (i.e., adopt more practices) or diversification (i.e. adopt different practices). We use data on 5314 randomly sampled households located in 38 sites in 15 countries across four regions (East and West Africa, South Asia, and Central America). We estimate empirical models designed to assess determinants of both intensification and diversification of adaptation activities at global scales. Aspects of adaptive capacity that are found to increase intensification of adaptation globally include variables associated with access to information and human capital, financial considerations, assets, household infrastructure and experience. In contrast, there are few global drivers of adaptive diversification, with a notable exception being access to weather information, which also increases adaptive intensification. Investigating reasons for adaptation indicate that conditions present in underdeveloped markets provide the primary impetus for adaptation, even in the context of climate change. We also compare determinants across spatial scales, which reveals a variety of local avenues through which policy interventions can relax economic constraints and boost agricultural adaptation for both intensification and diversification. For example, access to weather information does not affect intensification adaptation in Africa, but is significant at several sites in Bangladesh and India. Moreover, this information leads to diversification of adaptive activities on some sites in South Asia and Central America, but increases specialization in West and East Africa.

Diversification and intensification of agricultural adaptation from global to local scales

PubMed Central

Chen, Minjie; Wichmann, Bruno; Luckert, Marty; Winowiecki, Leigh; Förch, Wiebke

2018-01-01

Smallholder farming systems are vulnerable to a number of challenges, including continued population growth, urbanization, income disparities, land degradation, decreasing farm size and productivity, all of which are compounded by uncertainty of climatic patterns. Understanding determinants of smallholder farming practices is critical for designing and implementing successful interventions, including climate change adaptation programs. We examine two dimensions wherein smallholder farmers may adapt agricultural practices; through intensification (i.e., adopt more practices) or diversification (i.e. adopt different practices). We use data on 5314 randomly sampled households located in 38 sites in 15 countries across four regions (East and West Africa, South Asia, and Central America). We estimate empirical models designed to assess determinants of both intensification and diversification of adaptation activities at global scales. Aspects of adaptive capacity that are found to increase intensification of adaptation globally include variables associated with access to information and human capital, financial considerations, assets, household infrastructure and experience. In contrast, there are few global drivers of adaptive diversification, with a notable exception being access to weather information, which also increases adaptive intensification. Investigating reasons for adaptation indicate that conditions present in underdeveloped markets provide the primary impetus for adaptation, even in the context of climate change. We also compare determinants across spatial scales, which reveals a variety of local avenues through which policy interventions can relax economic constraints and boost agricultural adaptation for both intensification and diversification. For example, access to weather information does not affect intensification adaptation in Africa, but is significant at several sites in Bangladesh and India. Moreover, this information leads to diversification of adaptive activities on some sites in South Asia and Central America, but increases specialization in West and East Africa. PMID:29727457

The Differentiation of Adaptive Behaviours: Evidence from High and Low Performers

ERIC Educational Resources Information Center

Kane, Harrison; Oakland, Thomas David

2015-01-01

Background: Professionals who use measures of adaptive behaviour when working with special populations may assume that adaptive behaviour is a consistent and linear construct at various ability levels and thus believe the construct of adaptive behaviour is the same for high and low performers. That is, highly adaptive people simply are assumed to…

7 CFR 653.3 - Adaptation of technical standards.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 6 2012-01-01 2012-01-01 false Adaptation of technical standards. 653.3 Section 653.3..., DEPARTMENT OF AGRICULTURE SUPPORT ACTIVITIES TECHNICAL STANDARDS § 653.3 Adaptation of technical standards. Technical standards and criteria developed on a national basis may require special adaptation to meet local...

7 CFR 653.3 - Adaptation of technical standards.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 6 2014-01-01 2014-01-01 false Adaptation of technical standards. 653.3 Section 653.3..., DEPARTMENT OF AGRICULTURE SUPPORT ACTIVITIES TECHNICAL STANDARDS § 653.3 Adaptation of technical standards. Technical standards and criteria developed on a national basis may require special adaptation to meet local...

7 CFR 653.3 - Adaptation of technical standards.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 6 2011-01-01 2011-01-01 false Adaptation of technical standards. 653.3 Section 653.3..., DEPARTMENT OF AGRICULTURE SUPPORT ACTIVITIES TECHNICAL STANDARDS § 653.3 Adaptation of technical standards. Technical standards and criteria developed on a national basis may require special adaptation to meet local...

7 CFR 653.3 - Adaptation of technical standards.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 6 2013-01-01 2013-01-01 false Adaptation of technical standards. 653.3 Section 653.3..., DEPARTMENT OF AGRICULTURE SUPPORT ACTIVITIES TECHNICAL STANDARDS § 653.3 Adaptation of technical standards. Technical standards and criteria developed on a national basis may require special adaptation to meet local...

Autophagy at the gut interface - mucosal responses to stress and the consequences for inflammatory bowel diseases

PubMed Central

Huett, Alan; Xavier, Ramnik J.

2014-01-01

Autophagy is a conserved homeostatic process by which cells degrade and recycle cytoplasmic contents and organelles. Recently autophagy has come to prominence as a factor in many disease states, including inflammatory bowel diseases. In this review we explore the recent discoveries in autophagy and how these relate to the special conditions experienced by the gut mucosa. We will pay particular attention to autophagy as an innate immune process and its role in the development and education of the adaptive immune system. PMID:19575363

Waste treatment in silicon production operations

NASA Technical Reports Server (NTRS)

Coleman, Larry M. (Inventor); Tambo, William (Inventor)

1985-01-01

A battery of special burners, each adapted for the treatment of a particular range of waste material formed during the conversion of metallurgical grade silicon to high purity silane and silicon, is accompanied by a series arrangement of filters to recover fumed silica by-product and a scrubber to recover muriatic acid as another by-product. All of the wastes are processed, during normal and plant upset waste load conditions, to produce useful by-products in an environmentally acceptable manner rather than waste materials having associated handling and disposal problems.

Map Learning with a 3D Printed Interactive Small-Scale Model: Improvement of Space and Text Memorization in Visually Impaired Students

PubMed Central

Giraud, Stéphanie; Brock, Anke M.; Macé, Marc J.-M.; Jouffrais, Christophe

2017-01-01

Special education teachers for visually impaired students rely on tools such as raised-line maps (RLMs) to teach spatial knowledge. These tools do not fully and adequately meet the needs of the teachers because they are long to produce, expensive, and not versatile enough to provide rapid updating of the content. For instance, the same RLM can barely be used during different lessons. In addition, those maps do not provide any interactivity, which reduces students’ autonomy. With the emergence of 3D printing and low-cost microcontrollers, it is now easy to design affordable interactive small-scale models (SSMs) which are adapted to the needs of special education teachers. However, no study has previously been conducted to evaluate non-visual learning using interactive SSMs. In collaboration with a specialized teacher, we designed a SSM and a RLM representing the evolution of the geography and history of a fictitious kingdom. The two conditions were compared in a study with 24 visually impaired students regarding the memorization of the spatial layout and historical contents. The study showed that the interactive SSM improved both space and text memorization as compared to the RLM with braille legend. In conclusion, we argue that affordable home-made interactive small scale models can improve learning for visually impaired students. Interestingly, they are adaptable to any teaching situation including students with specific needs. PMID:28649209

Efficient Fluid Dynamic Design Optimization Using Cartesian Grids

NASA Technical Reports Server (NTRS)

Dadone, A.; Grossman, B.; Sellers, Bill (Technical Monitor)

2004-01-01

This report is subdivided in three parts. The first one reviews a new approach to the computation of inviscid flows using Cartesian grid methods. The crux of the method is the curvature-corrected symmetry technique (CCST) developed by the present authors for body-fitted grids. The method introduces ghost cells near the boundaries whose values are developed from an assumed flow-field model in vicinity of the wall consisting of a vortex flow, which satisfies the normal momentum equation and the non-penetration condition. The CCST boundary condition was shown to be substantially more accurate than traditional boundary condition approaches. This improved boundary condition is adapted to a Cartesian mesh formulation, which we call the Ghost Body-Cell Method (GBCM). In this approach, all cell centers exterior to the body are computed with fluxes at the four surrounding cell edges. There is no need for special treatment corresponding to cut cells which complicate other Cartesian mesh methods.

Adaptive thinking & leadership simulation game training for special forces officers.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Raybourn, Elaine Marie; Mendini, Kip; Heneghan, Jerry

Complex problem solving approaches and novel strategies employed by the military at the squad, team, and commander level are often best learned experimentally. Since live action exercises can be costly, advances in simulation game training technology offer exciting ways to enhance current training. Computer games provide an environment for active, critical learning. Games open up possibilities for simultaneous learning on multiple levels; players may learn from contextual information embedded in the dynamics of the game, the organic process generated by the game, and through the risks, benefits, costs, outcomes, and rewards of alternative strategies that result from decision making. Inmore » the present paper we discuss a multiplayer computer game simulation created for the Adaptive Thinking & Leadership (ATL) Program to train Special Forces Team Leaders. The ATL training simulation consists of a scripted single-player and an immersive multiplayer environment for classroom use which leverages immersive computer game technology. We define adaptive thinking as consisting of competencies such as negotiation and consensus building skills, the ability to communicate effectively, analyze ambiguous situations, be self-aware, think innovatively, and critically use effective problem solving skills. Each of these competencies is an essential element of leader development training for the U.S. Army Special Forces. The ATL simulation is used to augment experiential learning in the curriculum for the U.S. Army JFK Special Warfare Center & School (SWCS) course in Adaptive Thinking & Leadership. The school is incorporating the ATL simulation game into two additional training pipelines (PSYOPS and Civil Affairs Qualification Courses) that are also concerned with developing cultural awareness, interpersonal communication adaptability, and rapport-building skills. In the present paper, we discuss the design, development, and deployment of the training simulation, and emphasize how the multiplayer simulation game is successfully used in the Special Forces Officer training program.« less

Learning and adaptation: neural and behavioural mechanisms behind behaviour change

NASA Astrophysics Data System (ADS)

Lowe, Robert; Sandamirskaya, Yulia

2018-01-01

This special issue presents perspectives on learning and adaptation as they apply to a number of cognitive phenomena including pupil dilation in humans and attention in robots, natural language acquisition and production in embodied agents (robots), human-robot game play and social interaction, neural-dynamic modelling of active perception and neural-dynamic modelling of infant development in the Piagetian A-not-B task. The aim of the special issue, through its contributions, is to highlight some of the critical neural-dynamic and behavioural aspects of learning as it grounds adaptive responses in robotic- and neural-dynamic systems.

34 CFR 300.39 - Special education.

Code of Federal Regulations, 2010 CFR

2010-07-01

... hospitals and institutions, and in other settings; and (ii) Instruction in physical education. (2) Special... their parents as a part of the regular education program. (2) Physical education means— (i) The... (ii) Includes special physical education, adapted physical education, movement education, and motor...

Special home adaptation grants for members of the Armed Forces and veterans with certain vision impairment. Final rule.

PubMed

2014-09-12

The Department of Veterans Affairs (VA) is issuing a final rule to amend its adjudication regulations regarding special home adaptation grants for members of the Armed Forces and veterans with certain vision impairment. This regulatory amendment is necessary to conform the regulations to changes mandated in the Honoring America's Veterans and Caring for Camp Lejeune Families Act of 2012.

A robust adaptive flightpath reconstruction technique

NASA Technical Reports Server (NTRS)

Verhaegen, M. H.

1986-01-01

Computational schemes are presented that allow accurate reconstruction of an aircraft's flightpath in real-time. The reconstruction of the flightpath is formulated as a linear state reconstruction problem, which can be solved via Kalman filtering (KF) techniques. This imposes some conditions upon the flight-test equipment. A reliable square root covariance KF (SRCF) implementation is chosen and further developed into a fully adaptive flightpath reconstruction scheme. Therefore, the basic SRCF is modified in order to cope with several practical problems such as: the automatic control of the convergence of the recursive KF calculations, time varying zero-bias errors on the input signal of the system model used in the KF, and the changing aircraft dynamics owing to a change in reference flight condition. The developed solutions for these problems are all implemented in a numerically stable way, which guarantees the overall flightpath reconstruction scheme to be robust. Furthermore, some special features of the used system model are exploited to make the algorithmic implementation very efficient. An experimental simulation study using simulated flight test data demonstrated these different capabilities.

Stress-mediated translational control in cancer cells.

PubMed

Leprivier, Gabriel; Rotblat, Barak; Khan, Debjit; Jan, Eric; Sorensen, Poul H

2015-07-01

Tumor cells are continually subjected to diverse stress conditions of the tumor microenvironment, including hypoxia, nutrient deprivation, and oxidative or genotoxic stress. Tumor cells must evolve adaptive mechanisms to survive these conditions to ultimately drive tumor progression. Tight control of mRNA translation is critical for this response and the adaptation of tumor cells to such stress forms. This proceeds though a translational reprogramming process which restrains overall translation activity to preserve energy and nutrients, but which also stimulates the selective synthesis of major stress adaptor proteins. Here we present the different regulatory signaling pathways which coordinate mRNA translation in the response to different stress forms, including those regulating eIF2α, mTORC1 and eEF2K, and we explain how tumor cells hijack these pathways for survival under stress. Finally, mechanisms for selective mRNA translation under stress, including the utilization of upstream open reading frames (uORFs) and internal ribosome entry sites (IRESes) are discussed in the context of cell stress. This article is part of a Special Issue entitled: Translation and Cancer. Copyright © 2014 Elsevier B.V. All rights reserved.

Method of operator safety assessment for underground mobile mining equipment

NASA Astrophysics Data System (ADS)

Działak, Paulina; Karliński, Jacek; Rusiński, Eugeniusz

2018-01-01

The paper presents a method of assessing the safety of operators of mobile mining equipment (MME), which is adapted to current and future geological and mining conditions. The authors focused on underground mines, with special consideration of copper mines (KGHM). As extraction reaches into deeper layers of the deposit it can activate natural hazards, which, thus far, have been considered unusual and whose range and intensity are different depending on the field of operation. One of the main hazards that affect work safety and can become the main barrier in the exploitation of deposits at greater depths is climate threat. The authors have analysed the phenomena which may impact the safety of MME operators, with consideration of accidents that have not yet been studied and are not covered by the current safety standards for this group of miners. An attempt was made to develop a method for assessing the safety of MME operators, which takes into account the mentioned natural hazards and which is adapted to current and future environmental conditions in underground mines.

Development and Use of Curricular Adaptations for Students Receiving Special Education Services

ERIC Educational Resources Information Center

Kurth, Jennifer A.; Keegan, Lissa

2014-01-01

This study is a quasi-experimental descriptive design, with existing educator-made adaptations evaluated. The goals of this study were to (a) describe how educators develop adaptations and (b) evaluate the effectiveness of educator-made adaptations in facilitating the learning of students with disabilities. Findings suggest that (a) most…

Increasing the Adaptive Capacity of the Organism When Exposed to Adverse Environmental Factors Through Phytoadaptogens

NASA Astrophysics Data System (ADS)

Babii, N. V.; Pomozova, V. A.; Kiseleva, T. F.; Romanenko, V. O.

2017-07-01

The Problem of improving the quality of life of the population in modern conditions is the most relevant. The level of human health largely depends on the quality of the environment. Of special importance are the risk factors for the spread of diseases like environmental pollution, social conditions and bad habits. To the emergence of ecologically dependent diseases leads the combined impact of technogenic, social-economic, natural-climatic factors. The introduction of the principles of biotechnology, nanotechnology and innovations in industrial processing of plant resources, especially natural adaptogens, contributes to the production of balanced, ecologically clean food products functional purpose, the use of which will significantly minimize the adverse effects of the environment on humans.

IPCC Special Report on Managing the Risks of Extreme Events and Disasters to Advance Climate Change Adaptation

NASA Astrophysics Data System (ADS)

Field, C. B.; Stocker, T. F.; Barros, V. R.; Qin, D.; Ebi, K. L.; Midgley, P. M.

2011-12-01

The Summary for Policy Makers of the IPCC Special Report on Managing the Risks of Extreme Events and Disasters to Advance Climate Change Adaptation will be approved by the world governments in November 2011. The focus of the Special Report is on climate change and its role in altering the frequency, severity, and impact of extreme events or disasters, and on the costs of both impacts and the actions taken to prepare for, respond to, and recover from extreme events and disasters. The emphasis is on understanding the factors that make people and infrastructure vulnerable to extreme events, on recent and future changes in the relationship between climate change and extremes, and on managing the risks of disasters over a wide range of spatial and temporal scales. The assessment considers a broad suite of adaptations and explores the limits to adaptation. The assessment was designed to build durable links and foundations for partnerships between the stakeholder communities focused on climate change and those focused on disaster risk reduction. The Special Report begins with material that frames the issues, followed by an assessment of the reasons that communities are vulnerable. Two chapters assess the role of past and future climate change in altering extremes and the impact of these on the physical environment and human systems. Three chapters assess available knowledge on impacts and adaptation, with separate chapters considering the literature, stakeholder relationships, and potential policy tools relevant to the local, national, and international scales. Longer-term components of adaptation to weather and climate extremes and disasters are assessed in the context of moving toward sustainability. The final chapter provides case studies that integrate themes across several chapters or are so unique that they need to be considered separately.

The life-history basis of behavioural innovations

PubMed Central

Sol, Daniel; Sayol, Ferran; Ducatez, Simon; Lefebvre, Louis

2016-01-01

The evolutionary origin of innovativeness remains puzzling because innovating means responding to novel or unusual problems and hence is unlikely to be selected by itself. A plausible alternative is considering innovativeness as a co-opted product of traits that have evolved for other functions yet together predispose individuals to solve problems by adopting novel behaviours. However, this raises the question of why these adaptations should evolve together in an animal. Here, we develop the argument that the adaptations enabling animals to innovate evolve together because they are jointly part of a life-history strategy for coping with environmental changes. In support of this claim, we present comparative evidence showing that in birds, (i) innovative propensity is linked to life histories that prioritize future over current reproduction, (ii) the link is in part explained by differences in brain size, and (iii) innovative propensity and life-history traits may evolve together in generalist species that frequently expose themselves to novel or unusual conditions. Combined with previous evidence, these findings suggest that innovativeness is not a specialized adaptation but more likely part of a broader general adaptive system to cope with changes in the environment. PMID:26926277

A hierarchical model of the evolution of human brain specializations

PubMed Central

Barrett, H. Clark

2012-01-01

The study of information-processing adaptations in the brain is controversial, in part because of disputes about the form such adaptations might take. Many psychologists assume that adaptations come in two kinds, specialized and general-purpose. Specialized mechanisms are typically thought of as innate, domain-specific, and isolated from other brain systems, whereas generalized mechanisms are developmentally plastic, domain-general, and interactive. However, if brain mechanisms evolve through processes of descent with modification, they are likely to be heterogeneous, rather than coming in just two kinds. They are likely to be hierarchically organized, with some design features widely shared across brain systems and others specific to particular processes. Also, they are likely to be largely developmentally plastic and interactive with other brain systems, rather than canalized and isolated. This article presents a hierarchical model of brain specialization, reviewing evidence for the model from evolutionary developmental biology, genetics, brain mapping, and comparative studies. Implications for the search for uniquely human traits are discussed, along with ways in which conventional views of modularity in psychology may need to be revised. PMID:22723350

No oxygen? No problem! Intrinsic brain tolerance to hypoxia in vertebrates

PubMed Central

Larson, John; Drew, Kelly L.; Folkow, Lars P.; Milton, Sarah L.; Park, Thomas J.

2014-01-01

Many vertebrates are challenged by either chronic or acute episodes of low oxygen availability in their natural environments. Brain function is especially vulnerable to the effects of hypoxia and can be irreversibly impaired by even brief periods of low oxygen supply. This review describes recent research on physiological mechanisms that have evolved in certain vertebrate species to cope with brain hypoxia. Four model systems are considered: freshwater turtles that can survive for months trapped in frozen-over lakes, arctic ground squirrels that respire at extremely low rates during winter hibernation, seals and whales that undertake breath-hold dives lasting minutes to hours, and naked mole-rats that live in crowded burrows completely underground for their entire lives. These species exhibit remarkable specializations of brain physiology that adapt them for acute or chronic episodes of hypoxia. These specializations may be reactive in nature, involving modifications to the catastrophic sequelae of oxygen deprivation that occur in non-tolerant species, or preparatory in nature, preventing the activation of those sequelae altogether. Better understanding of the mechanisms used by these hypoxia-tolerant vertebrates will increase appreciation of how nervous systems are adapted for life in specific ecological niches as well as inform advances in therapy for neurological conditions such as stroke and epilepsy. PMID:24671961

Viruses are a dominant driver of protein adaptation in mammals.

PubMed

Enard, David; Cai, Le; Gwennap, Carina; Petrov, Dmitri A

2016-05-17

Viruses interact with hundreds to thousands of proteins in mammals, yet adaptation against viruses has only been studied in a few proteins specialized in antiviral defense. Whether adaptation to viruses typically involves only specialized antiviral proteins or affects a broad array of virus-interacting proteins is unknown. Here, we analyze adaptation in ~1300 virus-interacting proteins manually curated from a set of 9900 proteins conserved in all sequenced mammalian genomes. We show that viruses (i) use the more evolutionarily constrained proteins within the cellular functions they interact with and that (ii) despite this high constraint, virus-interacting proteins account for a high proportion of all protein adaptation in humans and other mammals. Adaptation is elevated in virus-interacting proteins across all functional categories, including both immune and non-immune functions. We conservatively estimate that viruses have driven close to 30% of all adaptive amino acid changes in the part of the human proteome conserved within mammals. Our results suggest that viruses are one of the most dominant drivers of evolutionary change across mammalian and human proteomes.

Viruses are a dominant driver of protein adaptation in mammals

PubMed Central

Enard, David; Cai, Le; Gwennap, Carina; Petrov, Dmitri A

2016-01-01

Viruses interact with hundreds to thousands of proteins in mammals, yet adaptation against viruses has only been studied in a few proteins specialized in antiviral defense. Whether adaptation to viruses typically involves only specialized antiviral proteins or affects a broad array of virus-interacting proteins is unknown. Here, we analyze adaptation in ~1300 virus-interacting proteins manually curated from a set of 9900 proteins conserved in all sequenced mammalian genomes. We show that viruses (i) use the more evolutionarily constrained proteins within the cellular functions they interact with and that (ii) despite this high constraint, virus-interacting proteins account for a high proportion of all protein adaptation in humans and other mammals. Adaptation is elevated in virus-interacting proteins across all functional categories, including both immune and non-immune functions. We conservatively estimate that viruses have driven close to 30% of all adaptive amino acid changes in the part of the human proteome conserved within mammals. Our results suggest that viruses are one of the most dominant drivers of evolutionary change across mammalian and human proteomes. DOI: http://dx.doi.org/10.7554/eLife.12469.001 PMID:27187613

No evidence for host specialization or host-race formation in the European bitterling (Rhodeus amarus), a fish that parasitizes freshwater mussels.

PubMed

Reichard, M; Bryja, J; Polačik, M; Smith, C

2011-09-01

Coevolutionary relationships between parasites and hosts can elevate the rate of evolutionary changes owing to reciprocal adaptations between coevolving partners. Such relationships can result in the evolution of host specificity. Recent methodological advances have permitted the recognition of cryptic lineages, with important consequences for our understanding of biological diversity. We used the European bitterling (Rhodeus amarus), a freshwater fish that parasitizes unionid mussels, to investigate host specialization across regions of recent and ancient sympatry between coevolving partners. We combined genetic data (12 microsatellite and 2 mitochondrial markers) from five populations with experimental data for possible mechanisms of host species recognition (imprinting and conditioning). We found no strong evidence for the existence of cryptic lineages in R. amarus, though a small proportion of variation among individuals in an area of recent bitterling-mussel association was statistically significant in explaining host specificity. No other measures supported the existence of host-specific lineages. Behavioural data revealed a weak effect of conditioning that biased behavioural preferences towards specific host species. Host imprinting had no effect on oviposition behaviour. Overall, we established that populations of R. amarus show limited potential for specialization, manifested as weak effects of host conditioning and genetic within-population structure. Rhodeus amarus is the only species of mussel-parasitizing fish in Europe, which contrasts with the species-rich communities of bitterling in eastern Asia where several host-specific bitterling occur. We discuss costs and constraints on the evolution of host-specific lineages in our study system and more generally. © 2011 Blackwell Publishing Ltd.

Dynamic Changes in Yeast Phosphatase Families Allow for Specialization in Phosphate and Thiamine Starvation.

PubMed

Nahas, John V; Iosue, Christine L; Shaik, Noor F; Selhorst, Kathleen; He, Bin Z; Wykoff, Dennis D

2018-05-10

Convergent evolution is often due to selective pressures generating a similar phenotype. We observe relatively recent duplications in a spectrum of Saccharomycetaceae yeast species resulting in multiple phosphatases that are regulated by different nutrient conditions - thiamine and phosphate starvation. This specialization is both transcriptional and at the level of phosphatase substrate specificity. In Candida glabrata , loss of the ancestral phosphatase family was compensated by the co-option of a different histidine phosphatase family with three paralogs. Using RNA-seq and functional assays, we identify one of these paralogs, CgPMU3 , as a thiamine phosphatase. We further determine that the 81% identical paralog CgPMU2 does not encode thiamine phosphatase activity; however, both are capable of cleaving the phosphatase substrate, 1-napthyl-phosphate. We functionally demonstrate that members of this family evolved novel enzymatic functions for phosphate and thiamine starvation, and are regulated transcriptionally by either nutrient condition, and observe similar trends in other yeast species. This independent, parallel evolution involving two different families of histidine phosphatases suggests that there were likely similar selective pressures on multiple yeast species to recycle thiamine and phosphate. In this work, we focused on duplication and specialization, but there is also repeated loss of phosphatases, indicating that the expansion and contraction of the phosphatase family is dynamic in many Ascomycetes. The dynamic evolution of the phosphatase gene families is perhaps just one example of how gene duplication, co-option, and transcriptional and functional specialization together allow species to adapt to their environment with existing genetic resources. Copyright © 2018, G3: Genes, Genomes, Genetics.

[Free radicals and hepatic ischemia-reperfusion].

PubMed

Szijártó, Attila

2015-11-22

The critical importance of the ischemic-reperfusive injury is well documented with regards to numerous organs and clinical conditions. Oxygen free radicals play a central role in the mediation of the injury, which dominantly influences the prevalence of postoperative complications, (long term) organ damage, and the potential manifestation of systemic reactions. The both anatomically and pathophysiologically unique ischemic-reperfusive injury of the liver, which is expressively vulnerable to free radicals, is of utmost importance in liver surgery. Several techniques (adaptive maneuvers, chemical agents) are known to ameliorate the reperfusive injury. Based on the prior research of the workgroup of the author, the aim of the current article is to overview the set of measures capable of attenuating ischemic-reperfusive injury (ischemic preconditioning, -perconditioning, administration of adenosine, -inosine, -levosimendan, and -poly-ADP-ribose-polymerase inhibitor), with special attention to the ischemic-reperfusive injury of the liver, as well as the special pathophysiological role of free radicals in mediating hepatic damage.

Getting Better All the Time: Using Music Technology for Learners with Special Needs

ERIC Educational Resources Information Center

Swingler, Tim; Brockhouse, John

2009-01-01

This paper focuses on the category of electronic musical instruments described as "gestural controllers"--motion sensor technology and specially adapted switches--which are widely used in special education. The therapeutic benefits of this technology in emancipating children from their cognitive or physical limitations are increasingly…

Steady-state capabilities for hydroturbines with OpenFOAM

NASA Astrophysics Data System (ADS)

Page, M.; Beaudoin, M.; Giroux, A. M.

2010-08-01

The availability of a high quality Open Source CFD simulation platform like OpenFOAM offers new R&D opportunities by providing direct access to models and solver implementation details. Efforts have been made by Hydro-Québec to adapt OpenFOAM to hydroturbines for the development of steady-state capabilities. The paper describes the developments that have been made to implement new turbomachinery related capabilities: Multiple Frame of Reference solver, domain coupling interfaces (GGI, cyclicGGI and mixing plane) and specialized boundary conditions. Practical use of the new turbomachinery capabilities are demonstrated for the analysis of a 195-MW Francis hydroturbine.

78 FR 11556 - Special Conditions: Embraer S.A., Model EMB-550 Airplane; Interaction of Systems and Structures

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-19

.... The primary structure is metal with composite empennage and control surfaces. The Model EMB-550...-1246; Special Conditions No. 25-481-SC] Special Conditions: Embraer S.A., Model EMB-550 Airplane... special conditions. SUMMARY: These special conditions are issued for the Embraer S.A. Model EMB-550...

78 FR 36084 - Special Conditions: Cirrus Design Corporation Model SF50 Airplane; Function and Reliability...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-17

...; Special Conditions No. 23-248-SC] Special Conditions: Cirrus Design Corporation Model SF50 Airplane... granting special conditions for the Cirrus Design Corporation model SF50 airplane. We are withdrawing... Special Condition No. 23-248- SC for the Cirrus Design Corporation new model SF50 ``Vision'' Jet. The SF50...

Fuzzy adaptive integration scheme for low-cost SINS/GPS navigation system

NASA Astrophysics Data System (ADS)

Nourmohammadi, Hossein; Keighobadi, Jafar

2018-01-01

Due to weak stand-alone accuracy as well as poor run-to-run stability of micro-electro mechanical system (MEMS)-based inertial sensors, special approaches are required to integrate low-cost strap-down inertial navigation system (SINS) with global positioning system (GPS), particularly in long-term applications. This paper aims to enhance long-term performance of conventional SINS/GPS navigation systems using a fuzzy adaptive integration scheme. The main concept behind the proposed adaptive integration is the good performance of attitude-heading reference system (AHRS) in low-accelerated motions and its degradation in maneuvered or accelerated motions. Depending on vehicle maneuvers, gravity-based attitude angles can be intelligently utilized to improve orientation estimation in the SINS. Knowledge-based fuzzy inference system is developed for decision-making between the AHRS and the SINS according to vehicle maneuvering conditions. Inertial measurements are the main input data of the fuzzy system to determine the maneuvering level during the vehicle motions. Accordingly, appropriate weighting coefficients are produced to combine the SINS/GPS and the AHRS, efficiently. The assessment of the proposed integrated navigation system is conducted via real data in airborne tests.

Analysis of Cross-Sectional Univariate Measurements for Family Dyads Using Linear Mixed Modeling

PubMed Central

Knafl, George J.; Dixon, Jane K.; O'Malley, Jean P.; Grey, Margaret; Deatrick, Janet A.; Gallo, Agatha M.; Knafl, Kathleen A.

2010-01-01

Outcome measurements from members of the same family are likely correlated. Such intrafamilial correlation (IFC) is an important dimension of the family as a unit but is not always accounted for in analyses of family data. This article demonstrates the use of linear mixed modeling to account for IFC in the important special case of univariate measurements for family dyads collected at a single point in time. Example analyses of data from partnered parents having a child with a chronic condition on their child's adaptation to the condition and on the family's general functioning and management of the condition are provided. Analyses of this kind are reasonably straightforward to generate with popular statistical tools. Thus, it is recommended that IFC be reported as standard practice reflecting the fact that a family dyad is more than just the aggregate of two individuals. Moreover, not accounting for IFC can affect the conclusions. PMID:19307316

46 CFR 385.61 - Grant and cooperative agreements: Special provisions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... and cooperative agreements: Special provisions. (a) MarAd has adopted two format matrices, one for...Ad will adapt the appropriate format matrix to the extent deemed necessary when drafting the...

46 CFR 385.61 - Grant and cooperative agreements: Special provisions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... and cooperative agreements: Special provisions. (a) MarAd has adopted two format matrices, one for...Ad will adapt the appropriate format matrix to the extent deemed necessary when drafting the...

[Do Current German-Language Intelligence Tests Take into Consideration the Special Needs of Children with Disabilities?].

PubMed

Mickley, Manfred; Renner, Gerolf

2015-01-01

Do Current German-Language Intelligence Tests Take into Consideration the Special Needs of Children with Disabilities? A review of 23 German intelligence test manuals shows that test-authors do not exclude the use of their tests for children with disabilities. However, these special groups play a minor role in the construction, standardization, and validation of intelligence tests. There is no sufficient discussion and reflection concerning the issue which construct-irrelevant requirements may reduce the validity of the test or which individual test-adaptations are allowed or recommended. Intelligence testing of children with disabilities needs more empirical evidence on objectivity, reliability, and validity of the assessment-procedures employed. Future test construction and validation should systematically analyze construct-irrelevant variance in item format, the special needs of handicapped children, and should give hints for useful test-adaptations.

Fast Dynamical Coupling Enhances Frequency Adaptation of Oscillators for Robotic Locomotion Control

PubMed Central

Nachstedt, Timo; Tetzlaff, Christian; Manoonpong, Poramate

2017-01-01

Rhythmic neural signals serve as basis of many brain processes, in particular of locomotion control and generation of rhythmic movements. It has been found that specific neural circuits, named central pattern generators (CPGs), are able to autonomously produce such rhythmic activities. In order to tune, shape and coordinate the produced rhythmic activity, CPGs require sensory feedback, i.e., external signals. Nonlinear oscillators are a standard model of CPGs and are used in various robotic applications. A special class of nonlinear oscillators are adaptive frequency oscillators (AFOs). AFOs are able to adapt their frequency toward the frequency of an external periodic signal and to keep this learned frequency once the external signal vanishes. AFOs have been successfully used, for instance, for resonant tuning of robotic locomotion control. However, the choice of parameters for a standard AFO is characterized by a trade-off between the speed of the adaptation and its precision and, additionally, is strongly dependent on the range of frequencies the AFO is confronted with. As a result, AFOs are typically tuned such that they require a comparably long time for their adaptation. To overcome the problem, here, we improve the standard AFO by introducing a novel adaptation mechanism based on dynamical coupling strengths. The dynamical adaptation mechanism enhances both the speed and precision of the frequency adaptation. In contrast to standard AFOs, in this system, the interplay of dynamics on short and long time scales enables fast as well as precise adaptation of the oscillator for a wide range of frequencies. Amongst others, a very natural implementation of this mechanism is in terms of neural networks. The proposed system enables robotic applications which require fast retuning of locomotion control in order to react to environmental changes or conditions. PMID:28377710

Computerized Adaptive Testing: Overview and Introduction.

ERIC Educational Resources Information Center

Meijer, Rob R.; Nering, Michael L.

1999-01-01

Provides an overview of computerized adaptive testing (CAT) and introduces contributions to this special issue. CAT elements discussed include item selection, estimation of the latent trait, item exposure, measurement precision, and item-bank development. (SLD)

Comparison of Rooting Strategies to Explore Rock Fractures for Shallow Soil-Adapted Tree Species with Contrasting Aboveground Growth Rates: A Greenhouse Microcosm Experiment

PubMed Central

Nie, Yunpeng; Chen, Hongsong; Ding, Yali; Yang, Jing; Wang, Kelin

2017-01-01

For tree species adapted to shallow soil environments, rooting strategies that efficiently explore rock fractures are important because soil water depletion occurs frequently. However, two questions: (a) to what extent shallow soil-adapted species rely on exploring rock fractures and (b) what outcomes result from drought stress, have rarely been tested. Therefore, based on the expectation that early development of roots into deep soil layers is at the cost of aboveground growth, seedlings of three tree species (Cyclobalanopsis glauca, Delavaya toxocarpa, and Acer cinnamomifolium) with distinct aboveground growth rates were selected from a typical shallow soil region. In a greenhouse experiment that mimics the basic features of shallow soil environments, 1-year-old seedlings were transplanted into simulated microcosms of shallow soil overlaying fractured bedrock. Root biomass allocation and leaf physiological activities, as well as leaf δ13C values were investigated and compared for two treatments: regular irrigation and repeated cycles of drought stress. Our results show that the three species differed in their rooting strategies in the context of encountering rock fractures, however, these strategies were not closely related to the aboveground growth rate. For the slowest-growing seedling, C. glauca, percentages of root mass in the fractures, as well as in the soil layer between soil and bedrock increased significantly under both treatments, indicating a specialized rooting strategy that facilitated the exploration of rock fractures. Early investment in deep root growth was likely critical to the establishment of this drought-vulnerable species. For the intermediate-growing, A. cinnamomifolium, percentages of root mass in the bedrock and interface soil layers were relatively low and exhibited no obvious change under either treatment. This limited need to explore rock fractures was compensated by a conservative water use strategy. For the fast-growing, D. toxocarpa, percentages of root mass in the bedrock and interface layers increased simultaneously under drought conditions, but not under irrigated conditions. This drought-induced rooting plasticity was associated with drought avoidance by this species. Although, root development might have been affected by the simulated microcosm, contrasting results among the three species indicated that efficient use of rock fractures is not a necessary or specialized strategy of shallow-soil adapted species. The establishment and persistence of these species relied on the mutual complementation between their species-specific rooting strategies and drought adaptations. PMID:29018464

Smoking Cessation: Next Steps for Special Populations Research and Innovative Treatments

ERIC Educational Resources Information Center

Borrelli, Belinda

2010-01-01

Objective: The current introductory article provides the rationale for the special section on understudied smokers and innovative treatments. This article proposes a definition of "special populations" of smokers, outlines a priori criteria by which to judge whether an intervention should be adapted for these smokers, and delineates a process by…

Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.

PubMed

Gaulin, Elodie; Pel, Michiel J C; Camborde, Laurent; San-Clemente, Hélène; Courbier, Sarah; Dupouy, Marie-Alexane; Lengellé, Juliette; Veyssiere, Marine; Le Ru, Aurélie; Grandjean, Frédéric; Cordaux, Richard; Moumen, Bouziane; Gilbert, Clément; Cano, Liliana M; Aury, Jean-Marc; Guy, Julie; Wincker, Patrick; Bouchez, Olivier; Klopp, Christophe; Dumas, Bernard

2018-04-18

Oomycetes are a group of filamentous eukaryotic microorganisms that have colonized all terrestrial and oceanic ecosystems, and they include prominent plant pathogens. The Aphanomyces genus is unique in its ability to infect both plant and animal species, and as such exemplifies oomycete versatility in adapting to different hosts and environments. Dissecting the underpinnings of oomycete diversity provides insights into their specificity and pathogenic mechanisms. By carrying out genomic analyses of the plant pathogen A. euteiches and the crustacean pathogen A. astaci, we show that host specialization is correlated with specialized secretomes that are adapted to the deconstruction of the plant cell wall in A. euteiches and protein degradation in A. astaci. The A. euteiches genome is characterized by a large repertoire of small secreted protein (SSP)-encoding genes that are highly induced during plant infection, and are not detected in other oomycetes. Functional analysis revealed an SSP from A. euteiches containing a predicted nuclear-localization signal which shuttles to the plant nucleus and increases plant susceptibility to infection. Collectively, our results show that Aphanomyces host adaptation is associated with evolution of specialized secretomes and identify SSPs as a new class of putative oomycete effectors.

Specialization to Extremely Low-Nutrient Soils Limits the Nutritional Adaptability of Plant Lineages.

PubMed

Verboom, G Anthony; Stock, William D; Cramer, Michael D

2017-06-01

Specialization to extreme selective situations promotes the acquisition of traits whose coadaptive integration may compromise evolutionary flexibility and adaptability. We test this idea in the context of the foliar stoichiometry of plants native to the South African Cape. Whereas foliar concentrations of nitrogen, phosphorus (P), potassium (K), calcium, magnesium, and sodium showed strong phylogenetic signal, as did the foliar ratios of these nutrients to P, the same was not true of the corresponding soil values. In addition, although foliar traits were often related to soil values, the coefficients of determination were consistently low. These results identify foliar stoichiometry as having a strong genetic component, with variation in foliar nutrient concentrations, especially [P] and [K], being identified as potentially adaptive. Comparison of stoichiometric variation across 11 similarly aged clades revealed consistently low foliar nutrient concentrations in lineages showing specialization to extremely low-nutrient fynbos heathlands. These lineages also display lower rates of evolution of these traits as well as a reduced tendency for foliar [P] to track soil [P]. Reduced evolutionary lability and adaptability in the nutritional traits of fynbos-specialist lineages may explain the floristic distinctness of the fynbos flora and implies a reduced scope for edaphically driven ecological speciation.

Neuromuscular adaptation to actual and simulated weightlessness

NASA Technical Reports Server (NTRS)

Edgerton, V. R.; Roy, R. R.

1994-01-01

The chronic "unloading" of the neuromuscular system during spaceflight has detrimental functional and morphological effects. Changes in the metabolic and mechanical properties of the musculature can be attributed largely to the loss of muscle protein and the alteration in the relative proportion of the proteins in skeletal muscle, particularly in the muscles that have an antigravity function under normal loading conditions. These adaptations could result in decrements in the performance of routine or specialized motor tasks, both of which may be critical for survival in an altered gravitational field, i.e., during spaceflight and during return to 1 G. For example, the loss in extensor muscle mass requires a higher percentage of recruitment of the motor pools for any specific motor task. Thus, a faster rate of fatigue will occur in the activated muscles. These consequences emphasize the importance of developing techniques for minimizing muscle loss during spaceflight, at least in preparation for the return to 1 G after spaceflight. New insights into the complexity and the interactive elements that contribute to the neuromuscular adaptations to space have been gained from studies of the role of exercise and/or growth factors as countermeasures of atrophy. The present chapter illustrates the inevitable interactive effects of neural and muscular systems in adapting to space. It also describes the considerable progress that has been made toward the goal of minimizing the functional impact of the stimuli that induce the neuromuscular adaptations to space.

Aspects regarding the hygienic-sanitary conditions at the level of certain dental medicine cabinets in Iasi County.

PubMed

Cernei, E R; Maxim, Dana Cristiana; Indrei, L L

2013-01-01

This baseline study aims to find out the evaluation of hygienic-sanitary conditions at the level of dental medicine cabinets through the verification of certain hygienic aspects. The study conducted consists in monitoring the hygienic/sanitary conditions at the level of 68 dental medicine cabinets (40 private cabinets and 28 school/university dental cabinets in Iasi county), using sheets for the assessment of the hygienic/sanitary conditions adapted from the control sheets of existing dental medicine cabinets at the level of DSP (Public Health Department) Iasi. The sheets for the assessment of the hygienic/sanitary conditions were evaluated by a specialized team and the results were i llustrated in the specific charts. At the level of all the dental cabinets the study revealed nonconformities regarding the means to carry out cleaning, disinfection operations, including the management of perilous waste, the control of medical personnel. An optimization of the hygienic-sanitary conditions at the level of dental medicine cabinets is still necessary, through participation to the activity of personnel training, who is directly involved in dental medical assistance.

Interdisciplinary approach to neurocritical care in the intensive care nursery.

PubMed

Glass, Hannah C; Rogers, Elizabeth E; Peloquin, Susan; Bonifacio, Sonia L

2014-12-01

Neurocritical care is a multidisciplinary subspecialty that combines expertise in critical care medicine, neurology, and neurosurgery, and has led to improved outcomes in adults who have critical illnesses. Advances in resuscitation and critical care have led to high rates of survival among neonates with life-threatening conditions such as perinatal asphyxia, extreme prematurity, and congenital malformations. The sequelae of neurologic conditions arising in the neonatal period include lifelong disabilities such as cerebral palsy and epilepsy, as well as intellectual and behavioral disabilities. Centers of excellence have adapted the principles of neurocritical care to reflect the needs of the developing newborn brain, including early involvement of a neurologist for recognition and treatment of neurologic conditions, attention to physiology to help prevent secondary brain injury, a protocol-driven approach for common conditions like seizures and hypoxic-ischemic encephalopathy, and education of specialized teams that use brain monitoring and imaging to evaluate the effect of critical illness on brain function and development. Copyright © 2014. Published by Elsevier Inc.

Non-parent of Origin Expression of Numerous Effector Genes Indicates a Role of Gene Regulation in Host Adaption of the Hybrid Triticale Powdery Mildew Pathogen.

PubMed

Praz, Coraline R; Menardo, Fabrizio; Robinson, Mark D; Müller, Marion C; Wicker, Thomas; Bourras, Salim; Keller, Beat

2018-01-01

Powdery mildew is an important disease of cereals. It is caused by one species, Blumeria graminis , which is divided into formae speciales each of which is highly specialized to one host. Recently, a new form capable of growing on triticale ( B.g. triticale ) has emerged through hybridization between wheat and rye mildews ( B.g. tritici and B.g. secalis , respectively). In this work, we used RNA sequencing to study the molecular basis of host adaptation in B.g. triticale . We analyzed gene expression in three B.g. tritici isolates, two B.g. secalis isolates and two B.g. triticale isolates and identified a core set of putative effector genes that are highly expressed in all formae speciales . We also found that the genes differentially expressed between isolates of the same form as well as between different formae speciales were enriched in putative effectors. Their coding genes belong to several families including some which contain known members of mildew avirulence ( Avr ) and suppressor ( Svr ) genes. Based on these findings we propose that effectors play an important role in host adaptation that is mechanistically based on Avr-Resistance gene-Svr interactions. We also found that gene expression in the B.g. triticale hybrid is mostly conserved with the parent-of-origin, but some genes inherited from B.g. tritici showed a B.g. secalis -like expression. Finally, we identified 11 unambiguous cases of putative effector genes with hybrid-specific, non-parent of origin gene expression, and we propose that they are possible determinants of host specialization in triticale mildew. These data suggest that altered expression of multiple effector genes, in particular Avr and Svr related factors, might play a role in mildew host adaptation based on hybridization.

Habitat specialization through germination cueing: a comparative study of herbs from forests and open habitats.

PubMed

Ten Brink, Dirk-Jan; Hendriksma, Harmen Pieter; Bruun, Hans Henrik

2013-02-01

This study examined the adaptive association between seed germination ecology and specialization to either forest or open habitats across a range of evolutionary lineages of seed plants, in order to test the hypotheses that (1) species' specialization to open vs. shaded habitats is consistently accompanied by specialization in their regeneration niche; and (2) species are thereby adapted to utilize different windows of opportunity in time (season) and space (habitat). Seed germination response to temperature, light and stratification was tested for 17 congeneric pairs, each consisting of one forest species and one open-habitat species. A factorial design was used with temperature levels and diurnal temperature variation (10 °C constant, 15-5 °C fluctuating, 20 °C constant, 25-15 °C fluctuating), and two light levels (light and darkness) and a cold stratification treatment. The congeneric species pair design took phylogenetic dependence into account. Species from open habitats germinated better at high temperatures, whereas forest species performed equally well at low and high temperatures. Forest species tended to germinate only after a period of cold stratification that could break dormancy, while species from open habitats generally germinated without cold stratification. The empirically derived germination strategies correspond quite well with establishment opportunities for forest and open-habitat plant species in nature. Annual changes in temperature and light regime in temperate forest delimit windows of opportunity for germination and establishment. Germination strategies of forest plants are adaptations to utilize such narrow windows in time. Conversely, lack of fit between germination ecology and environment may explain why species of open habitats generally fail to establish in forests. Germination strategy should be considered an important mechanism for habitat specialization in temperate herbs to forest habitats. The findings strongly suggest that phases in the plant life cycle other than the established phase should be considered important in adaptive specialization.

From Local Adaptation to Ecological Speciation in Copepod Populations from Neighboring Lakes

PubMed Central

Barrera-Moreno, Omar Alfredo; Ciros-Pérez, Jorge; Ortega-Mayagoitia, Elizabeth; Alcántara-Rodríguez, José Arturo; Piedra-Ibarra, Elías

2015-01-01

Continental copepods have been derived from several independent invasive events from the sea, but the subsequent evolutionary processes that account for the current diversity in lacustrine environments are virtually unknown. Salinity is highly variable among lakes and constitutes a source of divergent selection driving potential reproductive isolation. We studied four populations of the calanoid copepod Leptodiaptomus cf. sicilis inhabiting four neighboring lakes with a common history (since the Late Pleistocene) located in the Oriental Basin, Mexico; one lake is shallow and varies in salinity periodically (1.4–10 g L-1), while three are deep and permanent, with constant salinity (0.5, 1.1 and 6.5 g L-1, respectively). We hypothesized that (1) these populations belong to a different species than L. sicilis sensu stricto and (2) are experiencing ecologically based divergence due to salinity differences. We assessed morphological and molecular (mtDNA) COI variation, as well as fitness differences and tests of reproductive isolation. Although relationships of the Mexican populations with L. sicilis s.s. could not be elucidated, we identified a clear pattern of divergent selection driven by salinity conditions. The four populations can still be considered a single biological species (sexual recognition and hybridization are still possible in laboratory conditions), but they have diverged into at least three different phenotypes: two locally adapted, specialized in the lakes of constant salinity (saline vs. freshwater), and an intermediate generalist phenotype inhabiting the temporary lake with fluctuating salinity. The specialized phenotypes are poorly suited as migrants, so prezygotic isolation due to immigrant inviability is highly probable. This implication was supported by molecular evidence that showed restricted gene flow, persistence of founder events, and a pattern of allopatric fragmentation. This study showed how ecologically based divergent selection may explain diversification patterns in lacustrine copepods. PMID:25915059

Developing Tests of Visual Dependency

NASA Technical Reports Server (NTRS)

Kindrat, Alexandra N.

2011-01-01

Astronauts develop neural adaptive responses to microgravity during space flight. Consequently these adaptive responses cause maladaptive disturbances in balance and gait function when astronauts return to Earth and are re-exposed to gravity. Current research in the Neuroscience Laboratories at NASA-JSC is focused on understanding how exposure to space flight produces post-flight disturbances in balance and gait control and developing training programs designed to facilitate the rapid recovery of functional mobility after space flight. In concert with these disturbances, astronauts also often report an increase in their visual dependency during space flight. To better understand this phenomenon, studies were conducted with specially designed training programs focusing on visual dependency with the aim to understand and enhance subjects ability to rapidly adapt to novel sensory situations. The Rod and Frame test (RFT) was used first to assess an individual s visual dependency, using a variety of testing techniques. Once assessed, subjects were asked to perform two novel tasks under transformation (both the Pegboard and Cube Construction tasks). Results indicate that head position cues and initial visual test conditions had no effect on an individual s visual dependency scores. Subjects were also able to adapt to the manual tasks after several trials. Individual visual dependency correlated with ability to adapt manual to a novel visual distortion only for the cube task. Subjects with higher visual dependency showed decreased ability to adapt to this task. Ultimately, it was revealed that the RFT may serve as an effective prediction tool to produce individualized adaptability training prescriptions that target the specific sensory profile of each crewmember.

Conservatism and Adaptability during Squirrel Radiation: What Is Mandible Shape Telling Us?

PubMed Central

Casanovas-Vilar, Isaac; van Dam, Jan

2013-01-01

Both functional adaptation and phylogeny shape the morphology of taxa within clades. Herein we explore these two factors in an integrated way by analyzing shape and size variation in the mandible of extant squirrels using landmark-based geometric morphometrics in combination with a comparative phylogenetic analysis. Dietary specialization and locomotion were found to be reliable predictors of mandible shape, with the prediction by locomotion probably reflecting the underlying diet. In addition a weak but significant allometric effect could be demonstrated. Our results found a strong phylogenetic signal in the family as a whole as well as in the main clades, which is in agreement with the general notion of squirrels being a conservative group. This fact does not preclude functional explanations for mandible shape, but rather indicates that ancient adaptations kept a prominent role, with most genera having diverged little from their ancestral clade morphologies. Nevertheless, certain groups have evolved conspicuous adaptations that allow them to specialize on unique dietary resources. Such adaptations mostly occurred in the Callosciurinae and probably reflect their radiation into the numerous ecological niches of the tropical and subtropical forests of Southeastern Asia. Our dietary reconstruction for the oldest known fossil squirrels (Eocene, 36 million years ago) show a specialization on nuts and seeds, implying that the development from protrogomorphous to sciuromorphous skulls was not necessarily related to a change in diet. PMID:23593456

Bridging Body and Mind: Considerations for Trauma-Informed Yoga.

PubMed

Justice, Lauren; Brems, Christiane; Ehlers, Karrie

2018-02-08

Individuals who suffer from trauma-related symptoms are a unique population that could benefit from the mind-body practice of yoga-or have their symptoms reactivated by it, depending on the type of yoga. Trauma-informed yoga (TIY), that is, yoga adapted to the unique needs of individuals working to overcome trauma, may ameliorate symptoms by creating a safe, tailored practice for students to learn how to respond, rather than react, to symptoms and circumstances. Yoga not thus adapted, on the other hand, may increase reactivity and activate symptoms such as hyperarousal or dissociation. This article reports on expert input about adapting yoga for individuals with trauma, with special considerations for military populations. Eleven experts, recruited based on literature review and referrals, were interviewed in person or via telephone and asked seven questions about trauma-informed yoga. Verbatim transcripts were subjected to open-coding thematic analysis and a priori themes. Findings revealed that TIY needs to emphasize beneficial practices (e.g., diaphragmatic breath and restorative postures), consider contraindications (e.g., avoiding sequences that overly engage the sympathetic nervous system), adapt to limitations and challenges for teaching in unconventional settings (e.g., prisons, VA hospitals), and provide specialized training and preparation (e.g., specialized TIY certifications, self-care of instructors/therapists, adaptions for student needs). TIY for veterans must additionally consider gender- and culture-related barriers, differing relationships to pain and injury, and medication as a barrier to practice.

Competition, virulence, host body mass and the diversification of macro-parasites

PubMed Central

Rascalou, Guilhem; Gourbière, Sébastien

2014-01-01

Adaptive speciation has been much debated in recent years, with a strong emphasis on how competition can lead to the diversification of ecological and sexual traits. Surprisingly, little attention has been paid to this evolutionary process to explain intrahost diversification of parasites. We expanded the theory of competitive speciation to look at the effect of key features of the parasite lifestyle, namely fragmentation, aggregation and virulence, on the conditions and rate of sympatric speciation under the standard ‘pleiotropic scenario’. The conditions for competitive speciation were found similar to those for non-parasite species, but not the rate of diversification. Adaptive evolution proceeds faster in highly fragmented parasite populations and for weakly aggregated and virulent parasites. Combining these theoretical results with standard empirical allometric relationships, we showed that parasite diversification can be faster in host species of intermediate body mass. The increase in parasite load with body mass, indeed, fuels evolution by increasing mutants production, but because of the deleterious effect of virulence, it simultaneously weakens selection for resource specialization. Those two antagonistic effects lead to optimal parasite burden and host body mass for diversification. Data on the diversity of fishes' gills parasites were found consistent with the existence of such optimum. PMID:24522783

Brain–immune interactions and the neural basis of disease-avoidant ingestive behaviour

PubMed Central

Pacheco-López, Gustavo; Bermúdez-Rattoni, Federico

2011-01-01

Neuro–immune interactions are widely manifested in animal physiology. Since immunity competes for energy with other physiological functions, it is subject to a circadian trade-off between other energy-demanding processes, such as neural activity, locomotion and thermoregulation. When immunity is challenged, this trade-off is tilted to an adaptive energy protecting and reallocation strategy that is identified as ‘sickness behaviour’. We review diverse disease-avoidant behaviours in the context of ingestion, indicating that several adaptive advantages have been acquired by animals (including humans) during phylogenetic evolution and by ontogenetic experiences: (i) preventing waste of energy by reducing appetite and consequently foraging/hunting (illness anorexia), (ii) avoiding unnecessary danger by promoting safe environments (preventing disease encounter by olfactory cues and illness potentiation neophobia), (iii) help fighting against pathogenic threats (hyperthermia/somnolence), and (iv) by associative learning evading specific foods or environments signalling danger (conditioned taste avoidance/aversion) and/or at the same time preparing the body to counteract by anticipatory immune responses (conditioning immunomodulation). The neurobiology behind disease-avoidant ingestive behaviours is reviewed with special emphasis on the body energy balance (intake versus expenditure) and an evolutionary psychology perspective. PMID:22042916

Assessment of Climate Change Vulnerability at the Local Level: A Case Study on the Dniester River Basin (Moldova)

PubMed Central

Sîrodoev, Igor; Koeppel, Sonja; Denisov, Nickolai; Sîrodoev, Ghennadi

2013-01-01

Vulnerability to climate change of the Moldavian part of the Dniester river was assessed as the function of exposure, sensitivity, and adaptive capacity of its basin's natural and socioeconomic systems. As a spatial “scale” of the assessment, Moldova's administrative-territorial units (ATUs) were selected. The exposure assessment was based on the climatic analysis of baseline (1971–2000) temperature and precipitation and projections of their changes in 2021–2050, separately for cold and warm periods. The sensitivity assessment included physiographical and socioeconomic characteristics, described by a set of specific indicators. The adaptive capacity was expressed by general economic and agricultural indicators, taking into consideration the medical provision and housing conditions. Through a ranking approach, the relative vulnerability of each ATU was calculated by summing its sensitivity and adaptive capacity ranks; the latter were obtained as combinations of their primary indicator ranks, arranged in an increasing and decreasing order, respectively. Due to lack of sound knowledge on these components' importance in overall assessment of vulnerability, their weights were taken as conventionally equal. Mapping of vulnerability revealed that ATUs neighboring to municipalities are the most vulnerable and need special attention in climate change adaptation. The basin's “hotspots” were discussed with public participation. PMID:23766677

Dendritic cells in transplantation and immune-based therapies.

PubMed

Young, James W; Merad, Miriam; Hart, Derek N J

2007-01-01

Dendritic cells (DCs) are specialized, bone marrow-derived leukocytes critical to the onset of both innate and adaptive immunity. The divisions of labor among distinct human DC subtypes achieve the most effective balance between steady-state tolerance and the induction of innate and adaptive immunity against pathogens, tumors, and other insults. Maintenance of tolerance in the steady state is an active process involving resting or semimature DCs. Breakdowns in this homeostasis can result in autoimmunity. Perturbation of the steady state should first lead to the onset of innate immunity mediated by rapid responders in the form of plasmacytoid and monocyte-derived DC stimulators and natural killer (NK) and NK T-cell responders. These innate effectors then provide additional inflammatory cytokines, including interferon-gamma, which support the activation and maturation of resident and circulating populations of DCs. These are critical to the onset and expansion of adaptive immunity, including Th1, Th2, and cytotoxic T-lymphocyte responses. Rodent models are now revealing important data about distinct DC precursors, homeostasis of tissue-resident DCs, and DC turnover in response to inflammation and pathological conditions like graft-versus-host disease. The use of defined DC subtypes to stimulate both innate and adaptive immunity, either in combination or in a prime-boost vaccine sequence, may prove most useful clinically by harnessing both effector cell compartments.

Repeated adaptive divergence of microhabitat specialization in avian feather lice.

PubMed

Johnson, Kevin P; Shreve, Scott M; Smith, Vincent S

2012-06-20

Repeated adaptive radiations are evident when phenotypic divergence occurs within lineages, but this divergence into different forms is convergent when compared across lineages. Classic examples of such repeated adaptive divergence occur in island (for example, Caribbean Anolis lizards) and lake systems (for example, African cichlids). Host-parasite systems in many respects are analogous to island systems, where host species represent isolated islands for parasites whose life cycle is highly tied to that of their hosts. Thus, host-parasite systems might exhibit interesting cases of repeated adaptive divergence as seen in island and lake systems.The feather lice of birds spend their entire life cycle on the body of the host and occupy distinct microhabitats on the host: head, wing, body and generalist. These microhabitat specialists show pronounced morphological differences corresponding to how they escape from host preening. We tested whether these different microhabitat specialists were a case of repeated adaptive divergence by constructing both morphological and molecular phylogenies for a diversity of avian feather lice, including many examples of head, wing, body and generalist forms. Morphological and molecular based phylogenies were highly incongruent, which could be explained by rampant convergence in morphology related to microhabitat specialization on the host. In many cases lice from different microhabitat specializations, but from the same group of birds, were sister taxa. This pattern indicates a process of repeated adaptive divergence of these parasites within host group, but convergence when comparing parasites across host groups. These results suggest that host-parasite systems might be another case in which repeated adaptive radiations could be relatively common, but potentially overlooked, because morphological convergence can obscure evolutionary relationships.

Repeated adaptive divergence of microhabitat specialization in avian feather lice

PubMed Central

2012-01-01

Background Repeated adaptive radiations are evident when phenotypic divergence occurs within lineages, but this divergence into different forms is convergent when compared across lineages. Classic examples of such repeated adaptive divergence occur in island (for example, Caribbean Anolis lizards) and lake systems (for example, African cichlids). Host-parasite systems in many respects are analogous to island systems, where host species represent isolated islands for parasites whose life cycle is highly tied to that of their hosts. Thus, host-parasite systems might exhibit interesting cases of repeated adaptive divergence as seen in island and lake systems. The feather lice of birds spend their entire life cycle on the body of the host and occupy distinct microhabitats on the host: head, wing, body and generalist. These microhabitat specialists show pronounced morphological differences corresponding to how they escape from host preening. We tested whether these different microhabitat specialists were a case of repeated adaptive divergence by constructing both morphological and molecular phylogenies for a diversity of avian feather lice, including many examples of head, wing, body and generalist forms. Results Morphological and molecular based phylogenies were highly incongruent, which could be explained by rampant convergence in morphology related to microhabitat specialization on the host. In many cases lice from different microhabitat specializations, but from the same group of birds, were sister taxa. Conclusions This pattern indicates a process of repeated adaptive divergence of these parasites within host group, but convergence when comparing parasites across host groups. These results suggest that host-parasite systems might be another case in which repeated adaptive radiations could be relatively common, but potentially overlooked, because morphological convergence can obscure evolutionary relationships. PMID:22717002

Computers for the Disabled.

ERIC Educational Resources Information Center

Lazzaro, Joseph J.

1993-01-01

Describes adaptive technology for personal computers that accommodate disabled users and may require special equipment including hardware, memory, expansion slots, and ports. Highlights include vision aids, including speech synthesizers, magnification, braille, and optical character recognition (OCR); hearing adaptations; motor-impaired…

Gender perspectives in resilience, vulnerability and adaptation to global environmental change.

PubMed

Ravera, Federica; Iniesta-Arandia, Irene; Martín-López, Berta; Pascual, Unai; Bose, Purabi

2016-12-01

The main goal of this special issue is to offer a room for interdisciplinary and engaged research in global environmental change (GEC), where gender plays a key role in building resilience and adaptation pathways. In this editorial paper, we explain the background setting, key questions and core approaches of gender and feminist research in vulnerability, resilience and adaptation to GEC. Highlighting the interlinkages between gender and GEC, we introduce the main contributions of the collection of 11 papers in this special issue. Nine empirical papers from around the globe allow to understand how gendered diversity in knowledge, institutions and everyday practices matters in producing barriers and options for achieving resilience and adaptive capacity in societies. Additionally, two papers contribute to the theoretical debate through a systematic review and an insight on the relevance of intersectional framings within GEC research and development programming.

Pennsylvania's Exemplary Special Projects 1976-1990 as Reviewed and Rated by the FOCUS Panel.

ERIC Educational Resources Information Center

Royce, Sherry

This document reviews 117 special projects selected by a panel of literacy experts using three criteria: effectiveness, innovation, and adaptability. Special projects are grouped by the area, or major thrust, of the project and product. The nine areas are as follows: counseling, curriculum, English as a Second Language, management, promotion,…

D[superscript 4]S[superscript 4]: A Four Dimensions Instructional Strategy for Web-Based and Blended Learning

ERIC Educational Resources Information Center

Abdelaziz, Hamdy A.

2012-01-01

Web-based education is facing a paradigm shift under the rapid development of information and communication technology. The new paradigm of learning requires special techniques of course design, special instructional models, and special methods of evaluation. This paper investigates the effectiveness of an adaptive instructional strategy for…

Intraspecific ecological niche divergence and reproductive shifts foster cytotype displacement and provide ecological opportunity to polyploids.

PubMed

Karunarathne, Piyal; Schedler, Mara; Martínez, Eric J; Honfi, Ana I; Novichkova, Anastasiia; Hojsgaard, Diego

2018-05-11

Niche divergence between polyploids and their lower ploidy progenitors is one of the primary mechanisms fostering polyploid establishment and adaptive divergence. However, within-species chromosomal and reproductive variability have usually been neglected in community ecology and biodiversity analyses even though they have been recognized to play a role in the adaptive diversification of lineages. We used Paspalum intermedium, a grass species with diverging genetic systems (diploidy vs. autopolyploidy, allogamy vs. autogamy and sexuality vs. apomixis), to recognize the causality of biogeographic patterns, adaptation and ecological flexibility of cytotypes. Chromosome counts and flow cytometry were used to characterize within-species genetic systems diversity. Environmental niche modelling was used to evaluate intraspecific ecological attributes associated with environmental and climatic factors and to assess correlations among ploidy, reproductive modes and ecological conditions ruling species' population dynamics, range expansion, adaptation and evolutionary history. Two dominant cytotypes non-randomly distributed along local and regional geographical scales displayed niche differentiation, a directional shift in niche optima and signs of disruptive selection on ploidy-related ecological aptitudes for the exploitation of environmental resources. Ecologically specialized allogamous sexual diploids were found in northern areas associated with higher temperature, humidity and productivity, while generalist autogamous apomictic tetraploids occurred in southern areas, occupying colder and less productive environments. Four localities with a documented shift in ploidy and four mixed populations in a zone of ecological transition revealed an uneven replacement between cytotypes. Polyploidy and contrasting reproductive traits between cytotypes have promoted shifts in niche optima, and increased ecological tolerance and niche divergence. Ecologically specialized diploids maintain cytotype stability in core areas by displacing tetraploids, while broader ecological preferences and a shift from sexuality to apomixis favoured polyploid colonization in peripheral areas where diploids are displaced, and fostered the ecological opportunity for autotetraploids supporting range expansion to open southern habitats.

76 FR 44246 - Special Conditions: Boeing Model 747-8 Series Airplanes; Overhead Flight Attendant Rest Compartment

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-25

...; Special Conditions No. 25-442-SC] Special Conditions: Boeing Model 747-8 Series Airplanes; Overhead Flight... conditions. SUMMARY: These special conditions are issued for Boeing Model 747-8 series airplanes. These... applied for, and was granted, an extension of time for the amended type certificate, which changed the...

76 FR 38550 - Special Conditions: Boeing, Model 747-8 Series Airplanes; Door 1 Extendable Length Escape Slide

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-01

...; Special Conditions No. 25-438-SC] Special Conditions: Boeing, Model 747-8 Series Airplanes; Door 1... conditions. SUMMARY: These special conditions are issued for Boeing Model 747-8 airplanes. These airplanes... Federal Regulations (14 CFR) 21.101, Boeing must show that the Model 747-8 (hereafter referred as 747-8...

Circadian rhythm of a Silene species favours nocturnal pollination and constrains diurnal visitation

PubMed Central

Prieto-Benítez, Samuel; Dötterl, Stefan; Giménez-Benavides, Luis

2016-01-01

Background and Aims Traits related to flower advertisement and reward sometimes vary in a circadian way, reflecting phenotypic specialization. However, specialized flowers are not necessarily restricted to specialized pollinators. This is the case of most Silene species, typically associated with diurnal or nocturnal syndromes of pollination but usually showing complex suites of pollinators. Methods A Silene species with mixed floral features between diurnal and nocturnal syndromes was used to test how petal opening, nectar production, scent emission and pollination success correlate in a circadian rhythm, and whether this is influenced by environmental conditions. The effect of diurnal and nocturnal visitation rates on plant reproductive success is also explored in three populations, including the effect of the pollinating seed predator Hadena sancta. Key Results The result showed that repeated petal opening at dusk was correlated with nectar secretion and higher scent production during the night. However, depending on environmental conditions, petals remain opened for a while in the morning, when nectar and pollen still were available. Pollen deposition was similarly effective at night and in the morning, but less effective in the afternoon. These results were consistent with field studies. Conclusions The circadian rhythm regulating floral attractiveness and reward in S. colorata is predominantly adapted to nocturnal flower visitors. However, favourable environmental conditions lengthen the optimal daily period of flower attraction and pollination towards morning. This allows the complementarity of day and night pollination. Diurnal pollination may help to compensate the plant reproductive success when nocturnal pollinators are scarce and when the net outcome of H. sancta shifts from mutualism to parasitism. These results suggest a functional mechanism explaining why the supposed nocturnal syndrome of many Silene species does not successfully predict their pollinator guilds. PMID:27451986

Crater lake cichlids individually specialize along the benthic–limnetic axis

PubMed Central

Kusche, Henrik; Recknagel, Hans; Elmer, Kathryn Rebecca; Meyer, Axel

2014-01-01

A common pattern of adaptive diversification in freshwater fishes is the repeated evolution of elongated open water (limnetic) species and high-bodied shore (benthic) species from generalist ancestors. Studies on phenotype-diet correlations have suggested that population-wide individual specialization occurs at an early evolutionary and ecological stage of divergence and niche partitioning. This variable restricted niche use across individuals can provide the raw material for earliest stages of sympatric divergence. We investigated variation in morphology and diet as well as their correlations along the benthic-limnetic axis in an extremely young Midas cichlid species, Amphilophus tolteca, endemic to the Nicaraguan crater lake Asososca Managua. We found that A. tolteca varied continuously in ecologically relevant traits such as body shape and lower pharyngeal jaw morphology. The correlation of these phenotypes with niche suggested that individuals are specialized along the benthic-limnetic axis. No genetic differentiation within the crater lake was detected based on genotypes from 13 microsatellite loci. Overall, we found that individual specialization in this young crater lake species encompasses the limnetic-as well as the benthic macro-habitat. Yet there is no evidence for any diversification within the species, making this a candidate system for studying what might be the early stages preceding sympatric divergence. A common pattern of adaptive diversification in freshwater fishes is the repeated evolution of open water (limnetic) species and of shore (benthic) species. Individual specialization can reflect earliest stages of evolutionary and ecological divergence. We here demonstrate individual specialization along the benthic–limnetic axis in a young adaptive radiation of crater lake cichlid fishes. PMID:24772288

In-Flight Suppression of a De-Stabilized F/A-18 Structural Mode Using the Space Launch System Adaptive Augmenting Control System

NASA Technical Reports Server (NTRS)

Wall, John; VanZwieten, Tannen; Giiligan Eric; Miller, Chris; Hanson, Curtis; Orr, Jeb

2015-01-01

Adaptive Augmenting Control (AAC) has been developed for NASA's Space Launch System (SLS) family of launch vehicles and implemented as a baseline part of its flight control system (FCS). To raise the technical readiness level of the SLS AAC algorithm, the Launch Vehicle Adaptive Control (LVAC) flight test program was conducted in which the SLS FCS prototype software was employed to control the pitch axis of Dryden's specially outfitted F/A-18, the Full Scale Advanced Systems Test Bed (FAST). This presentation focuses on a set of special test cases which demonstrate the successful mitigation of the unstable coupling of an F/A-18 airframe structural mode with the SLS FCS.

Attaining Success for Beginning Special Education Teachers.

ERIC Educational Resources Information Center

McCabe, Marjorie; And Others

1993-01-01

Three case studies are presented that highlight problem scenarios relating to beginning special education intern teachers and explain how the teachers attained success. The cases focus on classroom management, adaptation of the core curriculum, and knowledge of instructional practices. (JDD)

Evolutionary Aspects and Regulation of Tetrapyrrole Biosynthesis in Cyanobacteria under Aerobic and Anaerobic Environments

PubMed Central

Fujita, Yuichi; Tsujimoto, Ryoma; Aoki, Rina

2015-01-01

Chlorophyll a (Chl) is a light-absorbing tetrapyrrole pigment that is essential for photosynthesis. The molecule is produced from glutamate via a complex biosynthetic pathway comprised of at least 15 enzymatic steps. The first half of the Chl pathway is shared with heme biosynthesis, and the latter half, called the Mg-branch, is specific to Mg-containing Chl a. Bilin pigments, such as phycocyanobilin, are additionally produced from heme, so these light-harvesting pigments also share many common biosynthetic steps with Chl biosynthesis. Some of these common steps in the biosynthetic pathways of heme, Chl and bilins require molecular oxygen for catalysis, such as oxygen-dependent coproporphyrinogen III oxidase. Cyanobacteria thrive in diverse environments in terms of oxygen levels. To cope with Chl deficiency caused by low-oxygen conditions, cyanobacteria have developed elaborate mechanisms to maintain Chl production, even under microoxic environments. The use of enzymes specialized for low-oxygen conditions, such as oxygen-independent coproporphyrinogen III oxidase, constitutes part of a mechanism adapted to low-oxygen conditions. Another mechanism adaptive to hypoxic conditions is mediated by the transcriptional regulator ChlR that senses low oxygen and subsequently activates the transcription of genes encoding enzymes that work under low-oxygen tension. In diazotrophic cyanobacteria, this multilayered regulation also contributes in Chl biosynthesis by supporting energy production for nitrogen fixation that also requires low-oxygen conditions. We will also discuss the evolutionary implications of cyanobacterial tetrapyrrole biosynthesis and regulation, because low oxygen-type enzymes also appear to be evolutionarily older than oxygen-dependent enzymes. PMID:25830590

From brain synapses to systems for learning and memory: Object recognition, spatial navigation, timed conditioning, and movement control.

PubMed

Grossberg, Stephen

2015-09-24

This article provides an overview of neural models of synaptic learning and memory whose expression in adaptive behavior depends critically on the circuits and systems in which the synapses are embedded. It reviews Adaptive Resonance Theory, or ART, models that use excitatory matching and match-based learning to achieve fast category learning and whose learned memories are dynamically stabilized by top-down expectations, attentional focusing, and memory search. ART clarifies mechanistic relationships between consciousness, learning, expectation, attention, resonance, and synchrony. ART models are embedded in ARTSCAN architectures that unify processes of invariant object category learning, recognition, spatial and object attention, predictive remapping, and eye movement search, and that clarify how conscious object vision and recognition may fail during perceptual crowding and parietal neglect. The generality of learned categories depends upon a vigilance process that is regulated by acetylcholine via the nucleus basalis. Vigilance can get stuck at too high or too low values, thereby causing learning problems in autism and medial temporal amnesia. Similar synaptic learning laws support qualitatively different behaviors: Invariant object category learning in the inferotemporal cortex; learning of grid cells and place cells in the entorhinal and hippocampal cortices during spatial navigation; and learning of time cells in the entorhinal-hippocampal system during adaptively timed conditioning, including trace conditioning. Spatial and temporal processes through the medial and lateral entorhinal-hippocampal system seem to be carried out with homologous circuit designs. Variations of a shared laminar neocortical circuit design have modeled 3D vision, speech perception, and cognitive working memory and learning. A complementary kind of inhibitory matching and mismatch learning controls movement. This article is part of a Special Issue entitled SI: Brain and Memory. Copyright © 2014 Elsevier B.V. All rights reserved.

Field-based insights to the evolution of specialization: plasticity and fitness across habitats in a specialist/generalist species pair.

PubMed

Griffith, Timothy; Sultan, Sonia E

2012-04-01

Factors promoting the evolution of specialists versus generalists have been little studied in ecological context. In a large-scale comparative field experiment, we studied genotypes from naturally evolved populations of a closely related generalist/specialist species pair (Polygonum persicaria and P. hydropiper), reciprocally transplanting replicates of multiple lines into open and partially shaded sites where the species naturally co-occur. We measured relative fitness, individual plasticity, herbivory, and genetic variance expressed in the contrasting light habitats at both low and high densities. Fitness data confirmed that the putative specialist out-performed the generalist in only one environment, the favorable full sun/low-density environment to which it is largely restricted in nature, while the generalist had higher lifetime reproduction in both canopy and dense neighbor shade. The generalist, P. persicaria, also expressed greater adaptive plasticity for biomass allocation and leaf size in shaded conditions than the specialist. We found no evidence that the ecological specialization of P. hydropiper reflects either genetically based fitness trade-offs or maintenance costs of plasticity, two types of genetic constraint often invoked to prevent the evolution of broadly adaptive genotypes. However, the patterns of fitness variance and herbivore damage revealed how release from herbivory in a new range can cause an introduced species to evolve as a specialist in that range, a surprising finding with important implications for invasion biology. Patterns of fitness variance between and within sites are also consistent with a possible role for the process of mutation accumulation (in this case, mutations affecting shade-expressed phenotypes) in the evolution and/or maintenance of specialization in P. hydropiper.

Field-based insights to the evolution of specialization: plasticity and fitness across habitats in a specialist/generalist species pair

PubMed Central

Griffith, Timothy; Sultan, Sonia E

2012-01-01

Factors promoting the evolution of specialists versus generalists have been little studied in ecological context. In a large-scale comparative field experiment, we studied genotypes from naturally evolved populations of a closely related generalist/specialist species pair (Polygonum persicaria and P. hydropiper), reciprocally transplanting replicates of multiple lines into open and partially shaded sites where the species naturally co-occur. We measured relative fitness, individual plasticity, herbivory, and genetic variance expressed in the contrasting light habitats at both low and high densities. Fitness data confirmed that the putative specialist out-performed the generalist in only one environment, the favorable full sun/low-density environment to which it is largely restricted in nature, while the generalist had higher lifetime reproduction in both canopy and dense neighbor shade. The generalist, P. persicaria, also expressed greater adaptive plasticity for biomass allocation and leaf size in shaded conditions than the specialist. We found no evidence that the ecological specialization of P. hydropiper reflects either genetically based fitness trade-offs or maintenance costs of plasticity, two types of genetic constraint often invoked to prevent the evolution of broadly adaptive genotypes. However, the patterns of fitness variance and herbivore damage revealed how release from herbivory in a new range can cause an introduced species to evolve as a specialist in that range, a surprising finding with important implications for invasion biology. Patterns of fitness variance between and within sites are also consistent with a possible role for the process of mutation accumulation (in this case, mutations affecting shade-expressed phenotypes) in the evolution and/or maintenance of specialization in P. hydropiper. PMID:22837826

Are adaptation costs necessary to build up a local adaptation pattern?

PubMed

Magalhães, Sara; Blanchet, Elodie; Egas, Martijn; Olivieri, Isabelle

2009-08-03

Ecological specialization is pervasive in phytophagous arthropods. In such specialization mode, limits to host range are imposed by trade-offs preventing adaptation to several hosts. The occurrence of such trade-offs is inferred by a pattern of local adaptation, i.e., a negative correlation between relative performance on different hosts. To establish a causal link between local adaptation and trade-offs, we performed experimental evolution of spider mites on cucumber, tomato and pepper, starting from a population adapted to cucumber. Spider mites adapted to each novel host within 15 generations and no further evolution was observed at generation 25. A pattern of local adaptation was found, as lines evolving on a novel host performed better on that host than lines evolving on other hosts. However, costs of adaptation were absent. Indeed, lines adapted to tomato had similar or higher performance on pepper than lines evolving on the ancestral host (which represent the initial performance of all lines) and the converse was also true, e.g. negatively correlated responses were not observed on the alternative novel host. Moreover, adapting to novel hosts did not result in decreased performance on the ancestral host. Adaptation did not modify host ranking, as all lines performed best on the ancestral host. Furthermore, mites from all lines preferred the ancestral to novel hosts. Mate choice experiments indicated that crosses between individuals from the same or from a different selection regime were equally likely, hence development of reproductive isolation among lines adapted to different hosts is unlikely. Therefore, performance and preference are not expected to impose limits to host range in our study species. Our results show that the evolution of a local adaptation pattern is not necessarily associated with the evolution of an adaptation cost.

Development of Methodologies for IV and V of Neural Networks

NASA Technical Reports Server (NTRS)

Taylor, Brian; Darrah, Marjorie

2003-01-01

Non-deterministic systems often rely upon neural network (NN) technology to "lean" to manage flight systems under controlled conditions using carefully chosen training sets. How can these adaptive systems be certified to ensure that they will become increasingly efficient and behave appropriately in real-time situations? The bulk of Independent Verification and Validation (IV&V) research of non-deterministic software control systems such as Adaptive Flight Controllers (AFC's) addresses NNs in well-behaved and constrained environments such as simulations and strict process control. However, neither substantive research, nor effective IV&V techniques have been found to address AFC's learning in real-time and adapting to live flight conditions. Adaptive flight control systems offer good extensibility into commercial aviation as well as military aviation and transportation. Consequently, this area of IV&V represents an area of growing interest and urgency. ISR proposes to further the current body of knowledge to meet two objectives: Research the current IV&V methods and assess where these methods may be applied toward a methodology for the V&V of Neural Network; and identify effective methods for IV&V of NNs that learn in real-time, including developing a prototype test bed for IV&V of AFC's. Currently. no practical method exists. lSR will meet these objectives through the tasks identified and described below. First, ISR will conduct a literature review of current IV&V technology. TO do this, ISR will collect the existing body of research on IV&V of non-deterministic systems and neural network. ISR will also develop the framework for disseminating this information through specialized training. This effort will focus on developing NASA's capability to conduct IV&V of neural network systems and to provide training to meet the increasing need for IV&V expertise in such systems.

Childhood disintegrative disorder with seasonal total mutism: A rare clinical presentation

PubMed Central

Shirazi, Elham; Hosseinpoor, Sara; Mirhosseini, Seyyed Mohammad Mahdy; Bidaki, Reza

2016-01-01

Childhood disintegrative disorder (CDD) is a rare autistic-like clinical condition with unknown etiology, in that previously acquired age-appropriate language, social and adaptive abilities deteriorate significantly in 2-10-year-old healthy children, although physical and neurological evaluations display no observable abnormality. Our case is a 22-year-old female born of a consanguineous marriage, with the appearance of CDD symptoms in her fifth year of age following normal mental and physical development during her initial four years of life. Without any precipitating factor, she gradually lost her language abilities, social relational skills, affectionate behavior, adaptive capacities, peer play and meaningful interest in her surrounding, friends and family members over a period of 4 years, reaching a plateau in her ninth year of age. The unique special clinical symptom in this case is a seasonal total mutism, which after the beginning of her CDD symptoms is revealing every year covering the spring. As no additional physical or psychological change accompanies her total seasonal speech loss, it cannot be attributed to any mental condition known as having a seasonal pattern. Because in the literature CDD is presented mostly as case reports with lacking of advanced research data, describing any new case is recommended to improve the knowledge about this rare condition, especially if it displays some new unusual signs, not reported till now. PMID:27069898

Geometrical optics model of Mie resonances

PubMed

Roll; Schweiger

2000-07-01

The geometrical optics model of Mie resonances is presented. The ray path geometry is given and the resonance condition is discussed with special emphasis on the phase shift that the rays undergo at the surface of the dielectric sphere. On the basis of this model, approximate expressions for the positions of first-order resonances are given. Formulas for the cavity mode spacing are rederived in a simple manner. It is shown that the resonance linewidth can be calculated regarding the cavity losses. Formulas for the mode density of Mie resonances are given that account for the different width of resonances and thus may be adapted to specific experimental situations.

Social and legal frame conditions for 3D (and) bioprinting in medicine.

PubMed

Bauer, Heide-Katharina; Heller, Martin; Fink, Matthias; Maresch, Daniela; Gartner, Johannes; Gassner, Ulrich M; Al-Nawas, Bilal

The beginnings of three-dimensional (3D) printing and bioprinting can be traced to as early as 1984. From printing inorganic models for the generation of biologic scaffolds, additive manufacturing (AM) developed to the direct printing of organic materials, including specialized tissues, proteins, and cells. In recent years, these technologies have gained significantly in relevance, and there have been several innovations, especially in the field of regenerative medicine. It is becoming increasingly important to consider the economic and social aspects of AM, particularly in education and information of medical human resources, society, and politics, as well as for the establishment of homogenous, globally adapted legal regulations.

Controller design for global fixed-time synchronization of delayed neural networks with discontinuous activations.

PubMed

Wang, Leimin; Zeng, Zhigang; Hu, Junhao; Wang, Xiaoping

2017-03-01

This paper addresses the controller design problem for global fixed-time synchronization of delayed neural networks (DNNs) with discontinuous activations. To solve this problem, adaptive control and state feedback control laws are designed. Then based on the two controllers and two lemmas, the error system is proved to be globally asymptotically stable and even fixed-time stable. Moreover, some sufficient and easy checked conditions are derived to guarantee the global synchronization of drive and response systems in fixed time. It is noted that the settling time functional for fixed-time synchronization is independent on initial conditions. Our fixed-time synchronization results contain the finite-time results as the special cases by choosing different values of the two controllers. Finally, theoretical results are supported by numerical simulations. Copyright © 2016 Elsevier Ltd. All rights reserved.

Severe macroglossia after posterior fossa and craniofacial surgery in children.

PubMed

Bouaoud, J; Joly, A; Picard, A; Thierry, B; Arnaud, E; James, S; Hennessy, I; McGarvey, B; Cairet, P; Vecchione, A; Vergnaud, E; Duracher, C; Khonsari, R H

2018-04-01

Massive swelling of the tongue can occur after posterior fossa and craniofacial surgery. Several hypotheses have been proposed to explain the occurrence of such severe postoperative macroglossia, but this phenomenon is still poorly understood. Severe postoperative macroglossia can be a life-threatening condition due to upper airway obstruction. Three cases of severe postoperative macroglossia that occurred after cervical spine, craniofacial, and posterior fossa surgical procedures are reported here. These cases required specialized maxillofacial management and a prolonged stay in the intensive care unit. Causal factors involved in this condition are reported, in order to highlight appropriate prevention and treatment options adapted to the management of paediatric patients. An overview of the current literature on severe postoperative macroglossia in paediatric populations is also provided. Copyright © 2017 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

Life-history trait plasticity and its relationships with plant adaptation and insect fitness: a case study on the aphid Sitobion avenae.

PubMed

Dai, Peng; Shi, Xiaoqin; Liu, Deguang; Ge, Zhaohong; Wang, Da; Dai, Xinjia; Yi, Zhihao; Meng, Xiuxiang

2016-07-18

Phenotypic plasticity has recently been considered a powerful means of adaptation, but its relationships with corresponding life-history characters and plant specialization levels of insects have been controversial. To address the issues, Sitobion avenae clones from three plants in two areas were compared. Varying amounts of life-history trait plasticity were found among S. avenae clones on barley, oat and wheat. In most cases, developmental durations and their corresponding plasticities were found to be independent, and fecundities and their plasticities were correlated characters instead. The developmental time of first instar nymphs for oat and wheat clones, but not for barley clones, was found to be independent from its plasticity, showing environment-specific effects. All correlations between environments were found to be positive, which could contribute to low plasticity in S. avenae. Negative correlations between trait plasticities and fitness of test clones suggest that lower plasticity could have higher adaptive value. Correlations between plasticity and specialization indices were identified for all clones, suggesting that plasticity might evolve as a by-product of adaptation to certain environments. The divergence patterns of life-history plasticities in S. avenae, as well as the relationships among plasticity, specialization and fitness, could have significant implications for evolutionary ecology of this aphid.

Host Plant Adaptation in Drosophila mettleri Populations

PubMed Central

Castrezana, Sergio; Bono, Jeremy M.

2012-01-01

The process of local adaptation creates diversity among allopatric populations, and may eventually lead to speciation. Plant-feeding insect populations that specialize on different host species provide an excellent opportunity to evaluate the causes of ecological specialization and the subsequent consequences for diversity. In this study, we used geographically separated Drosophila mettleri populations that specialize on different host cacti to examine oviposition preference for and larval performance on an array of natural and non-natural hosts (eight total). We found evidence of local adaptation in performance on saguaro cactus (Carnegiea gigantea) for populations that are typically associated with this host, and to chemically divergent prickly pear species (Opuntia spp.) in a genetically isolated population on Santa Catalina Island. Moreover, each population exhibited reduced performance on the alternative host. This finding is consistent with trade-offs associated with adaptation to these chemically divergent hosts, although we also discuss alternative explanations for this pattern. For oviposition preference, Santa Catalina Island flies were more likely to oviposit on some prickly pear species, but all populations readily laid eggs on saguaro. Experiments with non-natural hosts suggest that factors such as ecological opportunity may play a more important role than host plant chemistry in explaining the lack of natural associations with some hosts. PMID:22493678

Host plant adaptation in Drosophila mettleri populations.

PubMed

Castrezana, Sergio; Bono, Jeremy M

2012-01-01

The process of local adaptation creates diversity among allopatric populations, and may eventually lead to speciation. Plant-feeding insect populations that specialize on different host species provide an excellent opportunity to evaluate the causes of ecological specialization and the subsequent consequences for diversity. In this study, we used geographically separated Drosophila mettleri populations that specialize on different host cacti to examine oviposition preference for and larval performance on an array of natural and non-natural hosts (eight total). We found evidence of local adaptation in performance on saguaro cactus (Carnegiea gigantea) for populations that are typically associated with this host, and to chemically divergent prickly pear species (Opuntia spp.) in a genetically isolated population on Santa Catalina Island. Moreover, each population exhibited reduced performance on the alternative host. This finding is consistent with trade-offs associated with adaptation to these chemically divergent hosts, although we also discuss alternative explanations for this pattern. For oviposition preference, Santa Catalina Island flies were more likely to oviposit on some prickly pear species, but all populations readily laid eggs on saguaro. Experiments with non-natural hosts suggest that factors such as ecological opportunity may play a more important role than host plant chemistry in explaining the lack of natural associations with some hosts.

The Adaptive Edge: Introducing Adaptive Skills Techniques to Army Special Forces

DTIC Science & Technology

2010-12-01

Submitted in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE IN DEFENSE ANALYSIS from the NAVAL...Brian Greenshields Second Reader Gordon McCormick Chairman, Department of Defense Analysis iv THIS PAGE INTENTIONALLY LEFT BLANK v...Cultural Adaptability as: Taking action to learn about and understand the climate , orientation, needs, values of other groups, organizations, and

Technical Concept Document. Central Archive for Reusable Defense Software (CARDS)

DTIC Science & Technology

1994-02-28

FeNbry 1994 INFORMAL TECHNICAL REPORT For The SOFTWARE TECHNOLOGY FOR ADAPTABLE, RELIABLE SYSTEMS (STARS) Technical Concept Document Central Archive for...February 1994 INFORMAL TECHNICAL REPORT For The SOFTWARE TECHNOLOGY FOR ADAPTABLE, RELIABLE SYSTEMS (STARS) Technical Concept Document Central Archive...accordance with the DFARS Special Works Clause Developed by: This document, developed under the Software Technology for Adaptable, Reliable Systems

Adaptive Functioning and Behaviour Problems in Relation to Level of Education in Children and Adolescents with Intellectual Disability

ERIC Educational Resources Information Center

de Bildt, A.; Sytema, S.; Kraijer, D.; Sparrow, S.; Minderaa, R.

2005-01-01

Background: The interrelationship between adaptive functioning, behaviour problems and level of special education was studied in 186 children with IQs ranging from 61 to 70. The objective was to increase the insight into the contribution of adaptive functioning and general and autistic behaviour problems to the level of education in children with…

Barriers to adaptive reasoning in community ecology.

PubMed

McLachlan, Athol J; Ladle, Richard J

2011-08-01

Recent high-profile calls for a more trait-focused approach to community ecology have the potential to open up novel research areas, generate new insights and to transform community ecology into a more predictive science. However, a renewed emphasis on function and phenotype also requires a fundamental shift in approach and research philosophy within community ecology to more fully embrace evolutionary reasoning. Such a subject-wise transformation will be difficult due to at least four factors: (1) the historical development of the academic discipline of ecology and its roots as a descriptive science; (2) the dominating role of the ecosystem concept in the driving of contemporary ecological thought; (3) the practical difficulties associated with defining and identifying (phenotypic) adaptations, and; (4) scaling effects in ecology; the difficulty of teasing apart the overlapping and shifting hierarchical processes that generate the observed environment-trait correlations in nature. We argue that the ability to predict future ecological conditions through a sufficient understanding of ecological processes will not be achieved without the placement of the concept of adaptation at the centre of ecology, with influence radiating outwards through all the related (and rapidly specializing) sub-disciplines. © 2010 The Authors. Biological Reviews © 2010 Cambridge Philosophical Society.

Leveraging modern climatology to increase adaptive capacity across protected area networks

USGS Publications Warehouse

Davison, J.E.; Graumlich, L.J.; Rowland, E.L.; Pederson, G.T.; Breshears, D.D.

2012-01-01

Human-driven changes in the global environment pose an increasingly urgent challenge for the management of ecosystems that is made all the more difficult by the uncertain future of both environmental conditions and ecological responses. Land managers need strategies to increase regional adaptive capacity, but relevant and rapid assessment approaches are lacking. To address this need, we developed a method to assess regional protected area networks across biophysically important climatic gradients often linked to biodiversity and ecosystem function. We plot the land of the southwestern United States across axes of historical climate space, and identify landscapes that may serve as strategic additions to current protected area portfolios. Considering climate space is straightforward, and it can be applied using a variety of relevant climate parameters across differing levels of land protection status. The resulting maps identify lands that are climatically distinct from existing protected areas, and may be utilized in combination with other ecological and socio-economic information essential to collaborative landscape-scale decision-making. Alongside other strategies intended to protect species of special concern, natural resources, and other ecosystem services, the methods presented herein provide another important hedging strategy intended to increase the adaptive capacity of protected area networks. ?? 2011 Elsevier Ltd.

Cognitive Adaptations for n-person Exchange: The Evolutionary Roots of Organizational Behavior.

PubMed

Tooby, John; Cosmides, Leda; Price, Michael E

2006-03-01

Organizations are composed of stable, predominantly cooperative interactions or n -person exchanges. Humans have been engaging in n -person exchanges for a great enough period of evolutionary time that we appear to have evolved a distinct constellation of species-typical mechanisms specialized to solve the adaptive problems posed by this form of social interaction. These mechanisms appear to have been evolutionarily elaborated out of the cognitive infrastructure that initially evolved for dyadic exchange. Key adaptive problems that these mechanisms are designed to solve include coordination among individuals, and defense against exploitation by free riders. Multi-individual cooperation could not have been maintained over evolutionary time if free riders reliably benefited more than contributors to collective enterprises, and so outcompeted them. As a result, humans evolved mechanisms that implement an aversion to exploitation by free riding, and a strategy of conditional cooperation, supplemented by punitive sentiment towards free riders. Because of the design of these mechanisms, how free riding is treated is a central determinant of the survival and health of cooperative organizations. The mapping of the evolved psychology of n -party exchange cooperation may contribute to the construction of a principled theoretical foundation for the understanding of human behavior in organizations.

Cognitive Adaptations for n-person Exchange: The Evolutionary Roots of Organizational Behavior

PubMed Central

Tooby, John; Cosmides, Leda; Price, Michael E.

2013-01-01

Organizations are composed of stable, predominantly cooperative interactions or n-person exchanges. Humans have been engaging in n-person exchanges for a great enough period of evolutionary time that we appear to have evolved a distinct constellation of species-typical mechanisms specialized to solve the adaptive problems posed by this form of social interaction. These mechanisms appear to have been evolutionarily elaborated out of the cognitive infrastructure that initially evolved for dyadic exchange. Key adaptive problems that these mechanisms are designed to solve include coordination among individuals, and defense against exploitation by free riders. Multi-individual cooperation could not have been maintained over evolutionary time if free riders reliably benefited more than contributors to collective enterprises, and so outcompeted them. As a result, humans evolved mechanisms that implement an aversion to exploitation by free riding, and a strategy of conditional cooperation, supplemented by punitive sentiment towards free riders. Because of the design of these mechanisms, how free riding is treated is a central determinant of the survival and health of cooperative organizations. The mapping of the evolved psychology of n-party exchange cooperation may contribute to the construction of a principled theoretical foundation for the understanding of human behavior in organizations. PMID:23814325

Coupling of diversification and pH adaptation during the evolution of terrestrial Thaumarchaeota.

PubMed

Gubry-Rangin, Cécile; Kratsch, Christina; Williams, Tom A; McHardy, Alice C; Embley, T Martin; Prosser, James I; Macqueen, Daniel J

2015-07-28

The Thaumarchaeota is an abundant and ubiquitous phylum of archaea that plays a major role in the global nitrogen cycle. Previous analyses of the ammonia monooxygenase gene amoA suggest that pH is an important driver of niche specialization in these organisms. Although the ecological distribution and ecophysiology of extant Thaumarchaeota have been studied extensively, the evolutionary rise of these prokaryotes to ecological dominance in many habitats remains poorly understood. To characterize processes leading to their diversification, we investigated coevolutionary relationships between amoA, a conserved marker gene for Thaumarchaeota, and soil characteristics, by using deep sequencing and comprehensive environmental data in Bayesian comparative phylogenetics. These analyses reveal a large and rapid increase in diversification rates during early thaumarchaeotal evolution; this finding was verified by independent analyses of 16S rRNA. Our findings suggest that the entire Thaumarchaeota diversification regime was strikingly coupled to pH adaptation but less clearly correlated with several other tested environmental factors. Interestingly, the early radiation event coincided with a period of pH adaptation that enabled the terrestrial Thaumarchaeota ancestor to initially move from neutral to more acidic and alkaline conditions. In contrast to classic evolutionary models, whereby niches become rapidly filled after adaptive radiation, global diversification rates have remained stably high in Thaumarchaeota during the past 400-700 million years, suggesting an ongoing high rate of niche formation or switching for these microbes. Our study highlights the enduring importance of environmental adaptation during thaumarchaeotal evolution and, to our knowledge, is the first to link evolutionary diversification to environmental adaptation in a prokaryotic phylum.

Coupling of diversification and pH adaptation during the evolution of terrestrial Thaumarchaeota

PubMed Central

Gubry-Rangin, Cécile; Kratsch, Christina; Williams, Tom A.; McHardy, Alice C.; Embley, T. Martin; Prosser, James I.; Macqueen, Daniel J.

2015-01-01

The Thaumarchaeota is an abundant and ubiquitous phylum of archaea that plays a major role in the global nitrogen cycle. Previous analyses of the ammonia monooxygenase gene amoA suggest that pH is an important driver of niche specialization in these organisms. Although the ecological distribution and ecophysiology of extant Thaumarchaeota have been studied extensively, the evolutionary rise of these prokaryotes to ecological dominance in many habitats remains poorly understood. To characterize processes leading to their diversification, we investigated coevolutionary relationships between amoA, a conserved marker gene for Thaumarchaeota, and soil characteristics, by using deep sequencing and comprehensive environmental data in Bayesian comparative phylogenetics. These analyses reveal a large and rapid increase in diversification rates during early thaumarchaeotal evolution; this finding was verified by independent analyses of 16S rRNA. Our findings suggest that the entire Thaumarchaeota diversification regime was strikingly coupled to pH adaptation but less clearly correlated with several other tested environmental factors. Interestingly, the early radiation event coincided with a period of pH adaptation that enabled the terrestrial Thaumarchaeota ancestor to initially move from neutral to more acidic and alkaline conditions. In contrast to classic evolutionary models, whereby niches become rapidly filled after adaptive radiation, global diversification rates have remained stably high in Thaumarchaeota during the past 400–700 million years, suggesting an ongoing high rate of niche formation or switching for these microbes. Our study highlights the enduring importance of environmental adaptation during thaumarchaeotal evolution and, to our knowledge, is the first to link evolutionary diversification to environmental adaptation in a prokaryotic phylum. PMID:26170282

Skeletal Muscle Function during Exercise—Fine-Tuning of Diverse Subsystems by Nitric Oxide

PubMed Central

Suhr, Frank; Gehlert, Sebastian; Grau, Marijke; Bloch, Wilhelm

2013-01-01

Skeletal muscle is responsible for altered acute and chronic workload as induced by exercise. Skeletal muscle adaptations range from immediate change of contractility to structural adaptation to adjust the demanded performance capacities. These processes are regulated by mechanically and metabolically induced signaling pathways, which are more or less involved in all of these regulations. Nitric oxide is one of the central signaling molecules involved in functional and structural adaption in different cell types. It is mainly produced by nitric oxide synthases (NOS) and by non-enzymatic pathways also in skeletal muscle. The relevance of a NOS-dependent NO signaling in skeletal muscle is underlined by the differential subcellular expression of NOS1, NOS2, and NOS3, and the alteration of NO production provoked by changes of workload. In skeletal muscle, a variety of highly relevant tasks to maintain skeletal muscle integrity and proper signaling mechanisms during adaptation processes towards mechanical and metabolic stimulations are taken over by NO signaling. The NO signaling can be mediated by cGMP-dependent and -independent signaling, such as S-nitrosylation-dependent modulation of effector molecules involved in contractile and metabolic adaptation to exercise. In this review, we describe the most recent findings of NO signaling in skeletal muscle with a special emphasis on exercise conditions. However, to gain a more detailed understanding of the complex role of NO signaling for functional adaptation of skeletal muscle (during exercise), additional sophisticated studies are needed to provide deeper insights into NO-mediated signaling and the role of non-enzymatic-derived NO in skeletal muscle physiology. PMID:23538841

Comparative genomics reveals convergent evolution between the bamboo-eating giant and red pandas.

PubMed

Hu, Yibo; Wu, Qi; Ma, Shuai; Ma, Tianxiao; Shan, Lei; Wang, Xiao; Nie, Yonggang; Ning, Zemin; Yan, Li; Xiu, Yunfang; Wei, Fuwen

2017-01-31

Phenotypic convergence between distantly related taxa often mirrors adaptation to similar selective pressures and may be driven by genetic convergence. The giant panda (Ailuropoda melanoleuca) and red panda (Ailurus fulgens) belong to different families in the order Carnivora, but both have evolved a specialized bamboo diet and adaptive pseudothumb, representing a classic model of convergent evolution. However, the genetic bases of these morphological and physiological convergences remain unknown. Through de novo sequencing the red panda genome and improving the giant panda genome assembly with added data, we identified genomic signatures of convergent evolution. Limb development genes DYNC2H1 and PCNT have undergone adaptive convergence and may be important candidate genes for pseudothumb development. As evolutionary responses to a bamboo diet, adaptive convergence has occurred in genes involved in the digestion and utilization of bamboo nutrients such as essential amino acids, fatty acids, and vitamins. Similarly, the umami taste receptor gene TAS1R1 has been pseudogenized in both pandas. These findings offer insights into genetic convergence mechanisms underlying phenotypic convergence and adaptation to a specialized bamboo diet.

Comparative genomics reveals convergent evolution between the bamboo-eating giant and red pandas

PubMed Central

Hu, Yibo; Wu, Qi; Ma, Shuai; Ma, Tianxiao; Shan, Lei; Wang, Xiao; Nie, Yonggang; Ning, Zemin; Yan, Li; Xiu, Yunfang; Wei, Fuwen

2017-01-01

Phenotypic convergence between distantly related taxa often mirrors adaptation to similar selective pressures and may be driven by genetic convergence. The giant panda (Ailuropoda melanoleuca) and red panda (Ailurus fulgens) belong to different families in the order Carnivora, but both have evolved a specialized bamboo diet and adaptive pseudothumb, representing a classic model of convergent evolution. However, the genetic bases of these morphological and physiological convergences remain unknown. Through de novo sequencing the red panda genome and improving the giant panda genome assembly with added data, we identified genomic signatures of convergent evolution. Limb development genes DYNC2H1 and PCNT have undergone adaptive convergence and may be important candidate genes for pseudothumb development. As evolutionary responses to a bamboo diet, adaptive convergence has occurred in genes involved in the digestion and utilization of bamboo nutrients such as essential amino acids, fatty acids, and vitamins. Similarly, the umami taste receptor gene TAS1R1 has been pseudogenized in both pandas. These findings offer insights into genetic convergence mechanisms underlying phenotypic convergence and adaptation to a specialized bamboo diet. PMID:28096377

Effects of inclusion on the academic achievement and adaptive behaviour of children with intellectual disabilities.

PubMed

Dessemontet, R Sermier; Bless, G; Morin, D

2012-06-01

While an extensive body of research has examined the outcomes of inclusion for pupils with special needs, in particular learning disabilities, its effects on the development of children with intellectual disabilities (ID) have been less explored. As inclusive practices tend to be more common for this group of children, it is important to acquire more knowledge on this issue. A comparative study with an experimental group of 34 children with ID fully included in general education classrooms with support, and a control group of 34 comparable children in special schools has been conducted. The progress accomplished by these two groups in their academic achievement and adaptive behaviour has been compared over two school years. Included children made slightly more progress in literacy skills than children attending special schools. No differences were found between the progress of the two groups in mathematics and adaptive behaviour. Inclusive education is an appropriate educational option for primary pupils with ID who require extensive support in school. © 2011 The Authors. Journal of Intellectual Disability Research © 2011 Blackwell Publishing Ltd.

Managing the risks of extreme events and disasters to advance climate change adaptation. Special report of the Intergovernmental Panel on Climate Change (IPCC)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Field, C.B.; Barros, V.; Stocker, T.F.

2012-07-01

This Special Report on Managing the Risks of Extreme Events and Disasters to Advance Climate Change Adaptation (SREX) has been jointly coordinated by Working Groups I (WGI) and II (WGII) of the Intergovernmental Panel on Climate Change (IPCC). The report focuses on the relationship between climate change and extreme weather and climate events, the impacts of such events, and the strategies to manage the associated risks. This Special Report, in particular, contributes to frame the challenge of dealing with extreme weather and climate events as an issue in decision making under uncertainty, analyzing response in the context of risk management.more » The report consists of nine chapters, covering risk management; observed and projected changes in extreme weather and climate events; exposure and vulnerability to as well as losses resulting from such events; adaptation options from the local to the international scale; the role of sustainable development in modulating risks; and insights from specific case studies. (LN)« less

SPECIAL ISSUE ON OPTICAL PROCESSING OF INFORMATION: Optoelectronic processors with scanning CCD photodetectors

NASA Astrophysics Data System (ADS)

Esepkina, N. A.; Lavrov, A. P.; Anan'ev, M. N.; Blagodarnyi, V. S.; Ivanov, S. I.; Mansyrev, M. I.; Molodyakov, S. A.

1995-10-01

Two new types of optoelectronic radio-signal processors were investigated. Charge-coupled device (CCD) photodetectors are used in these processors under continuous scanning conditions, i.e. in a time delay and storage mode. One of these processors is based on a CCD photodetector array with a reference-signal amplitude transparency and the other is an adaptive acousto-optical signal processor with linear frequency modulation. The processor with the transparency performs multichannel discrete—analogue convolution of an input signal with a corresponding kernel of the transformation determined by the transparency. If a light source is an array of light-emitting diodes of special (stripe) geometry, the optical stages of the processor can be made from optical fibre components and the whole processor then becomes a rigid 'sandwich' (a compact hybrid optoelectronic microcircuit). A report is given also of a study of a prototype processor with optical fibre components for the reception of signals from a system with antenna aperture synthesis, which forms a radio image of the Earth.

Juvenile neuronal ceroid lipofuscinosis and education.

PubMed

von Tetzchner, Stephen; Fosse, Per; Elmerskog, Bengt

2013-11-01

Juvenile neuronal ceroid lipofuscinosis (JNCL) is characterized by severe visual impairment with onset around age 4-8 years, and a developmental course that includes blindness, epilepsy, speech problems, dementia, motor coordination problems, and emotional reactions. There is presently no cure and the disease leads to premature death. There have been few studies of non-medical intervention for individuals with JNCL, probably because of the negative prognosis. The present chapter discusses the education of children and adolescents with JNCL on the basis of current knowledge about the variation in perceptual, cognitive and language abilities through the course of the disease, and the possibilities that exist for supporting coping and learning within and outside the classroom. Adapted and special needs education may contribute significantly to improved learning conditions, better maintenance of skills and less frustration for individuals with JNCL. This article is part of a Special Issue entitled: The Neuronal Ceroid Lipofuscinoses or Batten Disease. Copyright © 2013 Elsevier B.V. All rights reserved.

Disease-Associated Plasmacytoid Dendritic Cells

PubMed Central

Li, Shuang; Wu, Jing; Zhu, Shan; Liu, Yong-Jun; Chen, Jingtao

2017-01-01

Plasmacytoid dendritic cells (pDCs), also called natural interferon (IFN)-producing cells, represent a specialized cell type within the innate immune system. pDCs are specialized in sensing viral RNA and DNA by toll-like receptor-7 and -9 and have the ability to rapidly produce massive amounts of type 1 IFNs upon viral encounter. After producing type 1 IFNs, pDCs differentiate into professional antigen-presenting cells, which are capable of stimulating T cells of the adaptive immune system. Chronic activation of human pDCs by self-DNA or mitochondrial DNA contributes to the pathogenesis of systemic lupus erythematosis and IFN-related autoimmune diseases. Under steady-state conditions, pDCs play an important role in immune tolerance. In many types of human cancers, recruitment of pDCs to the tumor microenvironment contributes to the induction of immune tolerance. Here, we provide a systemic review of recent progress in studies on the role of pDCs in human diseases, including cancers and autoimmune/inflammatory diseases. PMID:29085361

76 FR 26957 - Special Conditions: Boeing, Model 747-8 Series Airplanes; Door 1 Extendable Length Escape Slide

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-10

...; Notice No. 25-11-12-SC] Special Conditions: Boeing, Model 747-8 Series Airplanes; Door 1 Extendable... special conditions. SUMMARY: This action proposes special conditions for the Boeing Model 747-8 airplane... Boeing Company applied for an amendment to Type Certificate Number A20WE to include the Model 747-8...

Modes of Action for Mucosal Vaccine Adjuvants

PubMed Central

2017-01-01

Abstract Vaccine adjuvants induce innate immune responses and the addition of adjuvants to the vaccine helps to induce protective immunity in the host. Vaccines utilizing live attenuated or killed whole pathogens usually contain endogenous adjuvants, such as bacterial cell wall products and their genomic nucleic acids, which act as pathogen-associated molecular patterns and are sufficient to induce adaptive immune responses. However, purified protein- or antigen-based vaccines, including component or recombinant vaccines, usually lose these endogenous innate immune stimulators, so the addition of an exogenous adjuvant is essential for the success of these vaccine types. Although this adjuvant requirement is mostly the same for parental and mucosal vaccines, the development of mucosal vaccine adjuvants requires the specialized consideration of adapting the adjuvants to characteristic mucosal conditions. This review provides a brief overview of mucosa-associated immune response induction processes, such as antigen uptake and dendritic cell subset-dependent antigen presentation. It also highlights several mucosal vaccine adjuvants from recent reports, particularly focusing on their modes of action. PMID:28436755

Insect photoreceptor adaptations to night vision

PubMed Central

Honkanen, Anna; Salmela, Iikka; Weckström, Matti

2017-01-01

Night vision is ultimately about extracting information from a noisy visual input. Several species of nocturnal insects exhibit complex visually guided behaviour in conditions where most animals are practically blind. The compound eyes of nocturnal insects produce strong responses to single photons and process them into meaningful neural signals, which are amplified by specialized neuroanatomical structures. While a lot is known about the light responses and the anatomical structures that promote pooling of responses to increase sensitivity, there is still a dearth of knowledge on the physiology of night vision. Retinal photoreceptors form the first bottleneck for the transfer of visual information. In this review, we cover the basics of what is known about physiological adaptations of insect photoreceptors for low-light vision. We will also discuss major enigmas of some of the functional properties of nocturnal photoreceptors, and describe recent advances in methodologies that may help to solve them and broaden the field of insect vision research to new model animals. This article is part of the themed issue ‘Vision in dim light’. PMID:28193821

Modes of Action for Mucosal Vaccine Adjuvants.

PubMed

Aoshi, Taiki

Vaccine adjuvants induce innate immune responses and the addition of adjuvants to the vaccine helps to induce protective immunity in the host. Vaccines utilizing live attenuated or killed whole pathogens usually contain endogenous adjuvants, such as bacterial cell wall products and their genomic nucleic acids, which act as pathogen-associated molecular patterns and are sufficient to induce adaptive immune responses. However, purified protein- or antigen-based vaccines, including component or recombinant vaccines, usually lose these endogenous innate immune stimulators, so the addition of an exogenous adjuvant is essential for the success of these vaccine types. Although this adjuvant requirement is mostly the same for parental and mucosal vaccines, the development of mucosal vaccine adjuvants requires the specialized consideration of adapting the adjuvants to characteristic mucosal conditions. This review provides a brief overview of mucosa-associated immune response induction processes, such as antigen uptake and dendritic cell subset-dependent antigen presentation. It also highlights several mucosal vaccine adjuvants from recent reports, particularly focusing on their modes of action.

Adaptive memory: young children show enhanced retention of fitness-related information.

PubMed

Aslan, Alp; Bäuml, Karl-Heinz T

2012-01-01

Evolutionary psychologists propose that human cognition evolved through natural selection to solve adaptive problems related to survival and reproduction, with its ultimate function being the enhancement of reproductive fitness. Following this proposal and the evolutionary-developmental view that ancestral selection pressures operated not only on reproductive adults, but also on pre-reproductive children, the present study examined whether young children show superior memory for information that is processed in terms of its survival value. In two experiments, we found such survival processing to enhance retention in 4- to 10-year-old children, relative to various control conditions that also required deep, meaningful processing but were not related to survival. These results suggest that, already in very young children, survival processing is a special and extraordinarily effective form of memory encoding. The results support the functional-evolutionary proposal that young children's memory is "tuned" to process and retain fitness-related information. Copyright © 2011 Elsevier B.V. All rights reserved.

Impacts of environmental conditions on product formation and morphology of Yarrowia lipolytica.

PubMed

Timoumi, Asma; Guillouet, Stéphane E; Molina-Jouve, Carole; Fillaudeau, Luc; Gorret, Nathalie

2018-05-01

The yeast Yarrowia lipolytica is an industrially important microorganism with distinctive physiological and metabolic characteristics. A variety of external factors (e.g., pH, temperature, and nutrient availability) influences the behavior of the yeast and may act as stress conditions which the cells must withstand and adapt. In this mini review, the impacts of environmental factors on the morphology and metabolite production by Y. lipolytica are summarized. In this regard, detailed insights into the effectors involved in the dimorphic transition of Y. lipolytica, the cultivation conditions employed, as well as the methods applied for the morphological characterization are highlighted. Concerning the metabolism products, a special focus is addressed on lipid and citric acid metabolites which have attracted significant attention in recent years. The dependence of lipid and citric acid productivity on key process parameters, such as media composition and physico-chemical variables, is thoroughly discussed. This review attempts to provide a recent update on the topic and will serve as a meaningful resource for researchers working in the field.

Prioritized packet video transmission over time-varying wireless channel using proactive FEC

NASA Astrophysics Data System (ADS)

Kumwilaisak, Wuttipong; Kim, JongWon; Kuo, C.-C. Jay

2000-12-01

Quality of video transmitted over time-varying wireless channels relies heavily on the coordinated effort to cope with both channel and source variations dynamically. Given the priority of each source packet and the estimated channel condition, an adaptive protection scheme based on joint source-channel criteria is investigated via proactive forward error correction (FEC). With proactive FEC in Reed Solomon (RS)/Rate-compatible punctured convolutional (RCPC) codes, we study a practical algorithm to match the relative priority of source packets and instantaneous channel conditions. The channel condition is estimated to capture the long-term fading effect in terms of the averaged SNR over a preset window. Proactive protection is performed for each packet based on the joint source-channel criteria with special attention to the accuracy, time-scale match, and feedback delay of channel status estimation. The overall gain of the proposed protection mechanism is demonstrated in terms of the end-to-end wireless video performance.

[Sleep structure instability in healthy men under conditions of 105-day isolation experiment "Mars-105"].

PubMed

Kovrov, G V; Posokhov, S I; Posokhov, S S; Zavalko, I M; Ponomareva, I P

2013-01-01

Night-to-night stability of falling asleep and duration of wakefulness in the sleep was studied in six healthy male subjects under conditions of 105-day isolation experiment "Mars-105". Polysomnography records were carried out in each subject during five nights taken in regular intervals within the experiment. Three subjects demonstrated high stability of falling asleep and wakefulness in sleep (group I), whereas in the remaining three subjects stability of these characteristics was low (group [I). Delta-sleep was shown to be deepened in subjects of group II (significant prevalence of stage 4 (47.3 min) over stage 3 (32.9 min)). In subjects of group I, the duration of stage 3 was 44.9 min and that of stage 4 was 26.6 min. We suggest that night-to-night instability of falling asleep and duration of wakefulness in sleep in combination with delta sleep is the special individual form of sleep adaptation to conditions of chronic isolation stress.

Volleyball: Special Olympics Sports Skills Instructional Program.

ERIC Educational Resources Information Center

Special Olympics, Inc., Washington, DC.

One of seven booklets on Special Olympics Sports Skills Instructional Programs, this guide presents an instructional program for volleyball coaches working with mentally retarded persons. The instructional program presents information on the following topics: long term goals; short term objectives; modifications and adaptations of equipment, sport…

EDITORIAL: Adaptive and Active Materials: Selected Papers from the ASME 2008 Conference on Smart Materials, Adaptive Structures and Intelligent Systems (SMASIS 08) (Maryland, USA, 28-30 October 2008) Adaptive and Active Materials: Selected Papers from the ASME 2008 Conference on Smart Materials, Adaptive Structures and Intelligent Systems (SMASIS 08) (Maryland, USA, 28-30 October 2008)

NASA Astrophysics Data System (ADS)

Lynch, Christopher

2009-10-01

The rapid development of the field of Smart Materials, Adaptive Structures, and Materials Systems led the Aerospace Division ASMS TC to launch the new annual SMASIS conference in 2008. The conference focuses on the multi-disciplinary challenges of developing new multifunctional materials and implementing them in advanced systems. The research spans length scales from nano-structured materials to civil, air, and space structures. The first conference consisted of six symposia, each focusing on a different research area. This special issue of Smart Materials and Structures summarizes some of the top research presented at the 2008 SMASIS conference in the materials-focused symposia. These symposia focused on the behavior and mechanics of active materials, on multifunctional materials, and on bio-inspired materials. The behavior and mechanics of active materials is an approach that combines observed material behavior with mechanism-based models that not only give insight into the observed behavior, but guide the development of new materials. This approach has been applied to shape memory metals and polymers, ferroelectrics, ferromagnetics, and recently to multiferroic materials, and has led to considerable improvements in our understanding of multi-field phenomena. Multifunctional materials are the next generation of active materials. These materials include structural, sensing, and actuation components integrated into a material system. A natural extension of multifunctional materials is a new class of bio-inspired materials. Bio-inspired materials range from detailed bio-mimicry of sensing and self healing materials to nano and microstructures that take advantage of features observed in biological systems. The Editors would like to express their sincere thanks to all of the authors for their contributions to this special issue on 'Adaptive and Active Materials' for Smart Materials and Structures. We convey our gratitude to all of the reviewers for their time and dedication. We thank IOP Publishing for their support and encouragement of this special issue and the staff for their special attention and timely response.

Non-parent of Origin Expression of Numerous Effector Genes Indicates a Role of Gene Regulation in Host Adaption of the Hybrid Triticale Powdery Mildew Pathogen

PubMed Central

Praz, Coraline R.; Menardo, Fabrizio; Robinson, Mark D.; Müller, Marion C.; Wicker, Thomas; Bourras, Salim; Keller, Beat

2018-01-01

Powdery mildew is an important disease of cereals. It is caused by one species, Blumeria graminis, which is divided into formae speciales each of which is highly specialized to one host. Recently, a new form capable of growing on triticale (B.g. triticale) has emerged through hybridization between wheat and rye mildews (B.g. tritici and B.g. secalis, respectively). In this work, we used RNA sequencing to study the molecular basis of host adaptation in B.g. triticale. We analyzed gene expression in three B.g. tritici isolates, two B.g. secalis isolates and two B.g. triticale isolates and identified a core set of putative effector genes that are highly expressed in all formae speciales. We also found that the genes differentially expressed between isolates of the same form as well as between different formae speciales were enriched in putative effectors. Their coding genes belong to several families including some which contain known members of mildew avirulence (Avr) and suppressor (Svr) genes. Based on these findings we propose that effectors play an important role in host adaptation that is mechanistically based on Avr-Resistance gene-Svr interactions. We also found that gene expression in the B.g. triticale hybrid is mostly conserved with the parent-of-origin, but some genes inherited from B.g. tritici showed a B.g. secalis-like expression. Finally, we identified 11 unambiguous cases of putative effector genes with hybrid-specific, non-parent of origin gene expression, and we propose that they are possible determinants of host specialization in triticale mildew. These data suggest that altered expression of multiple effector genes, in particular Avr and Svr related factors, might play a role in mildew host adaptation based on hybridization. PMID:29441081

Computer-Adaptive Testing for Students with Disabilities: A Review of the Literature. Research Report. ETS RR-11-32

ERIC Educational Resources Information Center

Stone, Elizabeth; Davey, Tim

2011-01-01

There has been an increased interest in developing computer-adaptive testing (CAT) and multistage assessments for K-12 accountability assessments. The move to adaptive testing has been met with some resistance by those in the field of special education who express concern about routing of students with divergent profiles (e.g., some students with…

Co-Adaptive Aiding and Automation Enhance Operator Performance

DTIC Science & Technology

2013-03-01

activation system. There is a close relation between physiologically activated adaptive aiding and brain- computer interfaces ( BCI ). BCI here refers...classification of EEG signals (Farwell & Donchin, 1988). Physiologically activated adaptive aiding is, in a sense, a special case of BCI wherein the...as passive BCI , e.g. Zander, Kothe, Jatzev, & 3 Distribution A: Approved for public release; distribution unlimited. 88 ABW Cleared 05/13/2013

Individualized Special Education with Cognitive Skill Assessment.

ERIC Educational Resources Information Center

Kurhila, Jaakko; Laine, Tei

2000-01-01

Describes AHMED (Adaptive and Assistive Hypermedia in Education), a computer learning environment which supports the evaluation of disabled children's cognitive skills in addition to supporting openness in learning materials and adaptivity in learning events. Discusses cognitive modeling and compares it to previous intelligent tutoring systems.…

Simultaneous adaptation to size, distance, and curvature underwater.

PubMed

Vernoy, M W

1989-02-01

Perceptual adaptation to underwater size, distance, and curvature distortion was measured for four different adaptation conditions. These conditions consisted of (a) playing Chinese checkers underwater, (b) swimming with eyes open underwater, (c) viewing a square underwater, and (d) an air control. Significant adaptation to underwater distortions was recorded in all except the air control condition. In the viewing square condition a positive correlation between size and distance adaptation was noted. It was suggested that adaptation to curvature may have mediated the positive correlation. Possible applications for the training of divers are discussed.

An integrated framework for assessing vulnerability to climate change and developing adaptation strategies for coffee growing families in Mesoamerica.

PubMed

Baca, María; Läderach, Peter; Haggar, Jeremy; Schroth, Götz; Ovalle, Oriana

2014-01-01

The Mesoamerican region is considered to be one of the areas in the world most vulnerable to climate change. We developed a framework for quantifying the vulnerability of the livelihoods of coffee growers in Mesoamerica at regional and local levels and identify adaptation strategies. Following the Intergovernmental Panel on Climate Change (IPCC) concepts, vulnerability was defined as the combination of exposure, sensitivity and adaptive capacity. To quantify exposure, changes in the climatic suitability for coffee and other crops were predicted through niche modelling based on historical climate data and locations of coffee growing areas from Mexico, Guatemala, El Salvador and Nicaragua. Future climate projections were generated from 19 Global Circulation Models. Focus groups were used to identify nine indicators of sensitivity and eleven indicators of adaptive capacity, which were evaluated through semi-structured interviews with 558 coffee producers. Exposure, sensitivity and adaptive capacity were then condensed into an index of vulnerability, and adaptation strategies were identified in participatory workshops. Models predict that all target countries will experience a decrease in climatic suitability for growing Arabica coffee, with highest suitability loss for El Salvador and lowest loss for Mexico. High vulnerability resulted from loss in climatic suitability for coffee production and high sensitivity through variability of yields and out-migration of the work force. This was combined with low adaptation capacity as evidenced by poor post harvest infrastructure and in some cases poor access to credit and low levels of social organization. Nevertheless, the specific contributors to vulnerability varied strongly among countries, municipalities and families making general trends difficult to identify. Flexible strategies for adaption are therefore needed. Families need the support of government and institutions specialized in impacts of climate change and strengthening of farmer organizations to enable the adjustment of adaptation strategies to local needs and conditions.

An Integrated Framework for Assessing Vulnerability to Climate Change and Developing Adaptation Strategies for Coffee Growing Families in Mesoamerica

PubMed Central

Baca, María; Läderach, Peter; Haggar, Jeremy; Schroth, Götz; Ovalle, Oriana

2014-01-01

The Mesoamerican region is considered to be one of the areas in the world most vulnerable to climate change. We developed a framework for quantifying the vulnerability of the livelihoods of coffee growers in Mesoamerica at regional and local levels and identify adaptation strategies. Following the Intergovernmental Panel on Climate Change (IPCC) concepts, vulnerability was defined as the combination of exposure, sensitivity and adaptive capacity. To quantify exposure, changes in the climatic suitability for coffee and other crops were predicted through niche modelling based on historical climate data and locations of coffee growing areas from Mexico, Guatemala, El Salvador and Nicaragua. Future climate projections were generated from 19 Global Circulation Models. Focus groups were used to identify nine indicators of sensitivity and eleven indicators of adaptive capacity, which were evaluated through semi-structured interviews with 558 coffee producers. Exposure, sensitivity and adaptive capacity were then condensed into an index of vulnerability, and adaptation strategies were identified in participatory workshops. Models predict that all target countries will experience a decrease in climatic suitability for growing Arabica coffee, with highest suitability loss for El Salvador and lowest loss for Mexico. High vulnerability resulted from loss in climatic suitability for coffee production and high sensitivity through variability of yields and out-migration of the work force. This was combined with low adaptation capacity as evidenced by poor post harvest infrastructure and in some cases poor access to credit and low levels of social organization. Nevertheless, the specific contributors to vulnerability varied strongly among countries, municipalities and families making general trends difficult to identify. Flexible strategies for adaption are therefore needed. Families need the support of government and institutions specialized in impacts of climate change and strengthening of farmer organizations to enable the adjustment of adaptation strategies to local needs and conditions. PMID:24586328

The Development of a Gas–Liquid Two-Phase Flow Sensor Applicable to CBM Wellbore Annulus

PubMed Central

Wu, Chuan; Wen, Guojun; Han, Lei; Wu, Xiaoming

2016-01-01

The measurement of wellbore annulus gas–liquid two-phase flow in CBM (coalbed methane) wells is of great significance for reasonably developing gas drainage and extraction processes, estimating CBM output, judging the operating conditions of CBM wells and analyzing stratum conditions. Hence, a specially designed sensor is urgently needed for real-time measurement of gas–liquid two-phase flow in CBM wellbore annulus. Existing flow sensors fail to meet the requirements of the operating conditions of CBM wellbore annulus due to such factors as an inapplicable measurement principle, larger size, poor sealability, high installation accuracy, and higher requirements for fluid media. Therefore, based on the principle of a target flowmeter, this paper designs a new two-phase flow sensor that can identify and automatically calibrate different flow patterns of two-phase flows. Upon the successful development of the new flow sensor, lab and field tests were carried out, and the results show that the newly designed sensor, with a measurement accuracy of ±2.5%, can adapt to the operating conditions of CBM wells and is reliable for long-term work. PMID:27869708

The Development of a Gas-Liquid Two-Phase Flow Sensor Applicable to CBM Wellbore Annulus.

PubMed

Wu, Chuan; Wen, Guojun; Han, Lei; Wu, Xiaoming

2016-11-18

The measurement of wellbore annulus gas-liquid two-phase flow in CBM (coalbed methane) wells is of great significance for reasonably developing gas drainage and extraction processes, estimating CBM output, judging the operating conditions of CBM wells and analyzing stratum conditions. Hence, a specially designed sensor is urgently needed for real-time measurement of gas-liquid two-phase flow in CBM wellbore annulus. Existing flow sensors fail to meet the requirements of the operating conditions of CBM wellbore annulus due to such factors as an inapplicable measurement principle, larger size, poor sealability, high installation accuracy, and higher requirements for fluid media. Therefore, based on the principle of a target flowmeter, this paper designs a new two-phase flow sensor that can identify and automatically calibrate different flow patterns of two-phase flows. Upon the successful development of the new flow sensor, lab and field tests were carried out, and the results show that the newly designed sensor, with a measurement accuracy of ±2.5%, can adapt to the operating conditions of CBM wells and is reliable for long-term work.

Educational Supports for Students with Special Needs: Preservice Music Educators' Perceptions

ERIC Educational Resources Information Center

Whipple, Jennifer; VanWeelden, Kimberly

2012-01-01

Historically, music educators have expressed concerns about inadequate preparation to work with students with special needs, specifically desiring skills related to instruction adaptation. Research has indicated that educational supports (written words, color coding, icons, echoing, buddy system, and other visual aids) can be particularly…

Introduction to the Special Issue on "State-of-the-Art Sensor Technology in Japan 2015".

PubMed

Tokumitsu, Masahiro; Ishida, Yoshiteru

2016-08-23

This Special Issue, "State-of-the-Art Sensor Technology in Japan 2015", collected papers on different kinds of sensing technology: fundamental technology for intelligent sensors, information processing for monitoring humans, and information processing for adaptive and survivable sensor systems.[...].

A Special Kind of Tutor

ERIC Educational Resources Information Center

Anderson, Linda Brown

2007-01-01

Tutoring has long been recognized as superior to group instruction, especially for students with special needs. Tutors can adapt instruction to the learner's pace, learning style and level of understanding. Feedback and correction are immediate. Basic misunderstandings can be quickly identified and corrected. Tutoring also has emotional benefits:…

Art in the inclusion of children with special needs in dentistry.

PubMed

dos Santos, Marcio José Possari; de Aguiar, Sandra Maria Herondina Coelho Ávila

2011-01-01

The purpose of this study was to report the use of art and its segments as a source for inclusion of the children with special needs in dentistry. The application of the Art in social therapy activities and workshops was divided in modules: Session of Socialization, Complementary Workshops of Art and Activities, aiming at the cultural anamnesis and artistic preferences of the 313 participants, prior to their dental care treatment at CAOE (Center of Odontological Assistance to patients with special needs) FOA Unesp. According to preference of the participants that answered the questionnaires, the music and the painting are the artistic segments that proved to be most helpful in the activities of inclusion and adaptation. The authors concluded that the use of art in the adaptation and environmental inclusion of the patient, prior to dental procedures is favorable and efficient.

Differences in Nanostructure and Hydrophobicity of Cicada (Cryptotympana atrata) Forewing Surface with the Distribution of Precipitation

PubMed Central

Zhang, Jiajing; Watson, Gregory S.; Watson, Jolanta A.; Han, Dong

2018-01-01

Although the cicada wing has a variety of functions and the nanostructure and surface properties of many species have been extensively investigated, there are no reports investigating diversity of nanostructures and wetting properties within a single species collected at locations with different rainfall conditions. In this study, the hydrophobicity and nanostructure dimensions of the forewing surface of Cryptotympana atrata were measured, based on specimens collected from 12 distributions with varying precipitation averages in China and Japan. The relationships among hydrophobicity, nanostructures, and precipitation were analyzed, and the adaption of hydrophobic nanostructures under different wet environments is discussed. The precipitation of locations in the years the samples of C. atrata were collected only has an effect on the diameter and spacing of wing surface nanostructure, and the multiple years of precipitation may have an influence on the basic diameter and spacing, as well as the height of protrusions. The rougher the wing surface, the stronger the hydrophobicity which was observed from samples taken where the rainfall conditions of the collection years are high. To our knowledge, this is one special example providing evidence of hydrophobic nanostructures found on a biological surface of a single species which shows adaption for specific wet environments. PMID:29849761

Analysis of Small RNAs in Streptococcus mutans under Acid Stress-A New Insight for Caries Research.

PubMed

Liu, Shanshan; Tao, Ye; Yu, Lixia; Zhuang, Peilin; Zhi, Qinghui; Zhou, Yan; Lin, Huancai

2016-09-14

Streptococcus mutans (S. mutans) is the major clinical pathogen responsible for dental caries. Its acid tolerance has been identified as a significant virulence factor for its survival and cariogenicity in acidic conditions. Small RNAs (sRNAs) are recognized as key regulators of virulence and stress adaptation. Here, we constructed three libraries of sRNAs with small size exposed to acidic conditions for the first time, followed by verification using qRT-PCR. The levels of two sRNAs and target genes predicted to be bioinformatically related to acid tolerance were further evaluated under different acid stress conditions (pH 7.5, 6.5, 5.5, and 4.5) at three time points (0.5, 1, and 2 h). Meanwhile, bacterial growth characteristics and vitality were assessed. We obtained 1879 sRNAs with read counts of at least 100. One hundred and ten sRNAs were perfectly mapped to reported msRNAs in S. mutans. Ten out of 18 sRNAs were validated by qRT-PCR. The survival of bacteria declined as the acid was increased from pH 7.5 to 4.5 at each time point. The bacteria can proliferate under each pH except pH 4.5 with time. The levels of sRNAs gradually decreased from pH 7.5 to 5.5, and slightly increased in pH 4.5; however, the expression levels of target mRNAs were up-regulated in acidic conditions than in pH 7.5. These results indicate that some sRNAs are specially induced at acid stress conditions, involving acid adaptation, and provide a new insight into exploring the complex acid tolerance for S. mutans.

Pre-adaptations and the evolution of pollination by sexual deception: Cope's rule of specialization revisited.

PubMed

Vereecken, Nicolas J; Wilson, Carol A; Hötling, Susann; Schulz, Stefan; Banketov, Sergey A; Mardulyn, Patrick

2012-12-07

Pollination by sexual deception is arguably one of the most unusual liaisons linking plants and insects, and perhaps the most illustrative example of extreme floral specialization in angiosperms. While considerable progress has been made in understanding the floral traits involved in sexual deception, less is known about how this remarkable mimicry system might have arisen, the role of pre-adaptations in promoting its evolution and its extent as a pollination mechanism outside the few groups of plants (primarily orchids) where it has been described to date. In the Euro-Mediterranean region, pollination by sexual deception is traditionally considered to be the hallmark of the orchid genus Ophrys. Here, we introduce two new cases outside of Ophrys, in plant groups dominated by generalized, shelter-mimicking species. On the basis of phylogenetic reconstructions of ancestral pollination strategies, we provide evidence for independent and bidirectional evolutionary transitions between generalized (shelter mimicry) and specialized (sexual deception) pollination strategies in three groups of flowering plants, and suggest that pseudocopulation has evolved from pre-adaptations (floral colours, shapes and odour bouquets) that selectively attract male pollinators through shelter mimicry. These findings, along with comparative analyses of floral traits (colours and scents), shed light on particular phenotypic changes that might have fuelled the parallel evolution of these extraordinary pollination strategies. Collectively, our results provide the first substantive insights into how pollination sexual deception might have evolved in the Euro-Mediterranean region, and demonstrate that even the most extreme cases of pollinator specialization can reverse to more generalized interactions, breaking 'Cope's rule of specialization'.

Evolution of nectarivory in phyllostomid bats (Phyllostomidae Gray, 1825, Chiroptera: Mammalia).

PubMed

Datzmann, Thomas; von Helversen, Otto; Mayer, Frieder

2010-06-04

Bats of the family Phyllostomidae show a unique diversity in feeding specializations. This taxon includes species that are highly specialized on insects, blood, small vertebrates, fruits or nectar, and pollen. Feeding specialization is accompanied by morphological, physiological and behavioural adaptations. Several attempts were made to resolve the phylogenetic relationships within this family in order to reconstruct the evolutionary transitions accompanied by nutritional specialization. Nevertheless, the evolution of nectarivory remained equivocal. Phylogenetic reconstructions, based on a concatenated nuclear-and mitochondrial data set, revealed a paraphyletic relationship of nectarivorous phyllostomid bats. Our phylogenetic reconstructions indicate that the nectarivorous genera Lonchophylla and Lionycteris are closer related to mainly frugivorous phyllostomids of the subfamilies Rhinophyllinae, Stenodermatinae, Carolliinae, and the insectivorous Glyphonycterinae rather than to nectarivorous bats of the Glossophaginae. This suggests an independent origin of morphological adaptations to a nectarivorous lifestyle within Lonchophyllinae and Glossophaginae. Molecular clock analysis revealed a relatively short time frame of about ten million years for the divergence of subfamilies. Our study provides strong support for diphyly of nectarivorous phyllostomids. This is remarkable, since their morphological adaptations to nutrition, like elongated rostrums and tongues, reduced teeth and the ability to use hovering flight while ingestion, closely resemble each other. However, more precise examinations of their tongues (e.g. type and structure of papillae and muscular innervation) revealed levels of difference in line with an independent evolution of nectarivory in these bats.

Analyzing the sclerocarpy adaptations of the Pitheciidae mandible.

PubMed

Püschel, Thomas A; Marcé-Nogué, Jordi; Kaiser, Thomas M; Brocklehurst, Robert J; Sellers, William I

2018-04-17

Primates are interpreted to be ancestrally adapted to frugivory, although some modern groups show clear adaptations to other diets. Among them, pitheciids stand out for specifically predating seeds. This dietary specialization is known as sclerocarpy and refers to the extraction of seeds from surrounding hard tissues using the anterior dentition followed by the mastication of seeds by the molars. It has been proposed that Callicebus-Pithecia-Chiropotes-Cacajao represent a morphocline of increasingly specialized anatomical traits for sclerocarpic foraging. This study addresses whether there is a sclerocarpic specialization gradient in the mandibular morphology of pitheciids. Finite element analysis (FEA) was used to simulate two biting scenarios and the obtained stress values were compared between different pitheciids. Geometric morphometrics (GM) were used to display the morphological variation of this group. No support was found for the morphocline hypothesis from a biomechanical viewpoint since all pitheciins showed similar stress values and on average Chiropotes rather than Cacajao exhibited the strongest mandible. From a morphological perspective, it was found that there is indeed relative "robusticity" continuum in the pitheciid mandible for some aspects of shape as expected for the morphocline hypothesis, but this gradient could be related to other factors rather than sclerocarpic specialization. The present results are expected to contribute to a better insight regarding the ecomorphological relationship between mandibular morphology and mechanical performance among pitheciids. © 2018 Wiley Periodicals, Inc.

Collaboration and Access for Our Children: Music Educators and Special Educators Together. When Music Educators and Special Educators Work Together, All Students Are Likely to Benefit

ERIC Educational Resources Information Center

McCord, Kimberly; Watts, Emily H.

2006-01-01

In this article, the authors offer insight into the challenges of helping children with disabilities succeed in music through a collaborative effort of music educators and special educators. Making the curriculum flexible and accommodating a variety of learning styles produces better results and eliminates the need to customize adaptations for…

USSOCOM Fact Book: Special Operations Forces

DTIC Science & Technology

2010-01-01

units include the 75th Ranger Regiment, headquartered at Fort Benning, Ga.; 160th Special Operations Aviation Regiment (Airborne) at Fort Campbell, Ky...throughout the world Rangers are the masters of special light infantry operations. This lethal, agile, and flexible force is capable of executing a wide...responsiveness and reliability define the Ranger Regiment as the versatile and adaptive force of choice for missions of high risk and strategic importance in

Adaptation of Salvadoran Refugees in Montreal.

ERIC Educational Resources Information Center

Jacob, Andre

1992-01-01

Analyzes the situation of Salvadoran refugees of rural origin to Montreal (Canada), using life histories of 11 males and 11 females in Canada less than 5 years. This study of adaptation highlights the special needs of this population, particularly for information about social services and government programs. (SLD)

Curriculum Adaptation for Inclusive Classrooms.

ERIC Educational Resources Information Center

Neary, Tom; And Others

This manual on curriculum adaptation for inclusive classrooms was developed as part of the PEERS (Providing Education for Everyone in Regular Schools) Project, a 5-year collaborative systems change project in California to facilitate the integration of students with severe disabilities previously at special centers into services at regular school…

Advances in Psychotherapy for Depressed Older Adults.

PubMed

Raue, Patrick J; McGovern, Amanda R; Kiosses, Dimitris N; Sirey, Jo Anne

2017-09-01

We review recent advances in psychotherapies for depressed older adults, in particular those developed for special populations characterized by chronic medical illness, acute medical illness, cognitive impairment, and suicide risk factors. We review adaptations for psychotherapy to overcome barriers to its accessibility in non-specialty settings such as primary care, homebound or hard-to-reach older adults, and social service settings. Recent evidence supports the effectiveness of psychotherapies that target late-life depression in the context of specific comorbid conditions including COPD, heart failure, Parkinson's disease, stroke and other acute conditions, cognitive impairment, and suicide risk. Growing evidence supports the feasibility, acceptability, and effectiveness of psychotherapy modified for a variety of health care and social service settings. Research supports the benefits of selecting the type of psychotherapy based on a comprehensive assessment of the older adult's psychiatric, medical, functional, and cognitive status, and tailoring psychotherapy to the settings in which older depressed adults are most likely to present.

Role of mycorrhizal colonization in plant establishment on an alkaline gold mine tailing.

PubMed

Orłowska, Elzbieta; Orłowski, Dariusz; Mesjasz-Przybyłowicz, Jolanta; Turnau, Katarzyna

2011-02-01

The potential role of arbuscular mycorrhizal fungi (AMF) in the revegetation of an alkaline gold mine tailing was studied in Barberton, South Africa. The tailing, characterized by a slow spontaneous plant succession, is colonized by the shrub Dodonaea viscosa and the grasses, Andropogon eucomus and Imperata cylindrica, all colonized by AMF. The effectiveness of mycorrhizal colonization in grasses was tested under laboratory conditions using fungal isolates of various origins. Both grasses were highly mycorrhiza dependent, and the presence of mycorrhizal colonization significantly increased their biomass and survival rates. The fungi originating from the gold tailing were better adapted to the special conditions of the tailing than the control isolate. Although the total colonization rate found for native fungi was lower than for fungi from non-polluted sites, they were more vital and more effective in promoting plant growth. The results obtained might serve as a practical approach to the phytostabilization of alkaline gold tailings.

Maternal experience and soil origin influence interactions between resident species and a dominant invasive species.

PubMed

Stotz, Gisela C; Gianoli, Ernesto; Cahill, James F

2018-01-01

Invasive species dominance in invaded communities may not be long-lasting due to regulatory processes, such as plant-soil feedbacks and neighboring species adaptation. Further, the change in species competitive ability may be contingent upon neighbor identity (i.e., specialized response) or consistent across neighbors (i.e., generalized response). Specialized responses can facilitate overall coexistence, while generalized responses may result in competitive exclusion. We set up a greenhouse experiment to test, in three species, the effect of soil conditions (non-invaded vs. invaded soil) and maternal experience (offspring of maternal plants from invaded vs. non-invaded areas) on species competitive ability against the invader Bromus inermis and conspecifics. If changes in species competitive ability against B. inermis were also evident when interacting with conspecifics, it would suggest a generalized increased/decreased competitive ability. Maternal experience resulted in reduced suppression of B. inermis in the three species and no change in tolerance. On the other hand, tolerance to B. inermis was enhanced when plants grew in soil from invaded areas, compared to non-brome soil. Importantly, both the decreased suppression due to maternal experience with B. inermis and the increased tolerance in invaded soil appear to be invader specific, as no such effects were observed when interacting with conspecifics. Specialized responses should facilitate coexistence, as no individual/species is a weaker or stronger competitor against all other neighbors or under all local soil conditions. Further, the negative plant-soil feedback for B. inermis should facilitate native species recovery in invaded areas and result in lower B. inermis performance and dominance over time.

Global climate changes drive ecological specialization of mammal faunas: trends in rodent assemblages from the Iberian Plio-Pleistocene

PubMed Central

2013-01-01

Background Several macroevolutionary hypotheses propose a synchrony between climatic changes and variations in the structure of faunal communities. Some of them focus on the importance of the species ecological specialization because of its effects on evolutionary processes and the resultant patterns. Particularly, Vrba’s turnover pulse hypothesis and resource-use hypothesis revolve around the importance of biome inhabitation. In order to test these hypotheses, we used the Biomic Specialization Index, which is based on the number of biomes occupied by each species, and evaluated the changes in the relative importance of generalist and specialist rodents in more than forty fossil sites from the Iberian Plio-Pleistocene. Results Our results indicate that there was a decrease in the specialization degree of rodent faunas during the Pliocene due to the global cooling that triggered the onset of the glacial events of the Cenozoic (around 2.75 Ma). The subsequent faunal transition after this critical paleoenvironmental event was characterized by an increase of specialization related to the adaptation to the new environmental conditions, which was mainly associated with the Pleistocene radiation of Arvicolinae (voles). Conclusions The pattern of faunal turnover is correlated with the development of the modern glaciations in the Northern Hemisphere around 2.75 Ma, and represents a reorganization of the rodent communities, as suggested by the turnover pulse hypothesis. Our data also support the resource-use hypothesis, which presumes the role of the degree of specialization in resources specifically related to particular biomes as a driver of differential speciation and extinction rates. These results stress the intimate connection between ecological and evolutionary changes. PMID:23627696

Universal Design of Research: Inclusion of Persons with Disabilities in Mainstream Biomedical Studies

PubMed Central

Williams, Ann S.; Moore, Shirley M.

2012-01-01

Although persons with disabilities of all kinds have as wide a range of health conditions as the general population, they are profoundly underrepresented in mainstream health research. Such underrepresentation might contribute to the health disparities in this population. We propose the concept of Universal Design of Research (UDR), which would promote routine inclusion of persons with disabilities in mainstream biomedical studies, without the need for adaptation or specialized design. Elements of UDR include the use of multi-sensory formats for recruiting participants, presenting research instruments and interventions, and data gathering from participants, and should promote the inclusion of participants with a wide range of abilities, thus enhancing the generalizability of results. PMID:21562227

Universal design of research: inclusion of persons with disabilities in mainstream biomedical studies.

PubMed

Williams, Ann S; Moore, Shirley M

2011-05-11

Although persons with disabilities of all kinds have as wide a range of health conditions as the general population, they are profoundly underrepresented in mainstream health research. Such underrepresentation might contribute to the health disparities in this population. We propose the concept of Universal Design of Research (UDR), which would promote routine inclusion of persons with disabilities in mainstream biomedical and psychosocial studies, without the need for adaptation or specialized design. Elements of UDR include the use of multisensory formats for recruiting participants, presenting research instruments and interventions, and data gathering from participants and should promote the inclusion of participants with a wide range of abilities, thus enhancing the generalizability of results.

Testing methods and techniques: Strength of materials and components. A compilation

NASA Technical Reports Server (NTRS)

1971-01-01

The methods, techniques, and devices used in testing the mechanical properties of various materials are presented. Although metals and metal alloys are featured prominently, some of the items describe tests on a variety of other materials, from concrete to plastics. Many of the tests described are modifications of standard testing procedures, intended either to adapt them to different materials and conditions, or to make them more rapid and accurate. In either case, the approaches presented can result in considerable cost savings and improved quality control. The compilation is presented in two sections. The first deals specifically with material strength testing; the second treats the special category of fracture and fatigue testing.

Unique Study Designs in Nephrology: N-of-1 Trials and Other Designs.

PubMed

Samuel, Joyce P; Bell, Cynthia S

2016-11-01

Alternatives to the traditional parallel-group trial design may be required to answer clinical questions in special populations, rare conditions, or with limited resources. N-of-1 trials are a unique trial design which can inform personalized evidence-based decisions for the patient when data from traditional clinical trials are lacking or not generalizable. A concise overview of factorial design, cluster randomization, adaptive designs, crossover studies, and n-of-1 trials will be provided along with pertinent examples in nephrology. The indication for analysis strategies such as equivalence and noninferiority trials will be discussed, as well as analytic pitfalls. Copyright © 2016 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

Cell Wall Assembly and Intracellular Trafficking in Plant Cells Are Directly Affected by Changes in the Magnitude of Gravitational Acceleration

PubMed Central

Chebli, Youssef; Pujol, Lauranne; Shojaeifard, Anahid; Brouwer, Iman; van Loon, Jack J. W. A.; Geitmann, Anja

2013-01-01

Plants are able to sense the magnitude and direction of gravity. This capacity is thought to reside in selected cell types within the plant body that are equipped with specialized organelles called statoliths. However, most plant cells do not possess statoliths, yet they respond to changes in gravitational acceleration. To understand the effect of gravity on the metabolism and cellular functioning of non-specialized plant cells, we investigated a rapidly growing plant cell devoid of known statoliths and without gravitropic behavior, the pollen tube. The effects of hyper-gravity and omnidirectional exposure to gravity on intracellular trafficking and on cell wall assembly were assessed in Camellia pollen tubes, a model system with highly reproducible growth behavior in vitro. Using an epi-fluorescence microscope mounted on the Large Diameter Centrifuge at the European Space Agency, we were able to demonstrate that vesicular trafficking is reduced under hyper-gravity conditions. Immuno-cytochemistry confirmed that both in hyper and omnidirectional gravity conditions, the characteristic spatial profiles of cellulose and callose distribution in the pollen tube wall were altered, in accordance with a dose-dependent effect on pollen tube diameter. Our findings suggest that in response to gravity induced stress, the pollen tube responds by modifying cell wall assembly to compensate for the altered mechanical load. The effect was reversible within few minutes demonstrating that the pollen tube is able to quickly adapt to changing stress conditions. PMID:23516452

Data-Adaptable Modeling and Optimization for Runtime Adaptable Systems

DTIC Science & Technology

2016-06-08

execution scenarios e . Enables model -guided optimization algorithms that outperform state-of-the-art f. Understands the overhead of system...the Data-Adaptable System Model (DASM), that facilitates design by enabling the designer to: 1) specify both an application’s task flow as well as...systems. The MILAN [3] framework specializes in the design, simulation , and synthesis of System On Chip (SoC) applications using model -based techniques

International Perspectives on Adapted Physical Activity. Selected Papers Presented at the International Symposium on Adapted Physical Activity (5th, Toronto, Canada, October 1-4, 1985).

ERIC Educational Resources Information Center

Berridge, Mavis E., Ed.; Ward, Graham R., Ed.

The 36 papers in this book were presented at the Fifth International Symposium on Adapted Physical Activity. Presentations document some of the research findings and new ideas in physical education and recreation programs designed to improve the quality of life for special populations. The collection represents the breadth of the field, from the…

Traffic-Adaptive, Flow-Specific Medium Access for Wireless Networks

DTIC Science & Technology

2009-09-01

hybrid, contention and non-contention schemes are shown to be special cases. This work also compares the energy efficiency of centralized and distributed...solutions and proposes an energy efficient version of traffic-adaptive CWS-MAC that includes an adaptive sleep cycle coordinated through the use of...preamble sampling. A preamble sampling probability parameter is introduced to manage the trade-off between energy efficiency and throughput and delay

Adaptive Memory: Is Survival Processing Special?

ERIC Educational Resources Information Center

Nairne, James S.; Pandeirada, Josefa N. S.

2008-01-01

Do the operating characteristics of memory continue to bear the imprints of ancestral selection pressures? Previous work in our laboratory has shown that human memory may be specially tuned to retain information processed in terms of its survival relevance. A few seconds of survival processing in an incidental learning context can produce recall…

Computer-Supported Instructional Communication: A Multidisciplinary Account of Relevant Factors

ERIC Educational Resources Information Center

Rummel, Nikol; Kramer, Nicole

2010-01-01

The papers in the present special issue summarize research that aims at compiling and understanding variables associated with successful communication in computer-supported instructional settings. Secondly, the papers add to the question of how adaptiveness of instructional communication may be achieved. A particular strength of the special issue…

78 FR 75997 - Provision of Early Intervention and Special Education Services to Eligible DoD Dependents

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-13

... individuals with disabilities; selecting, designing, fitting, customizing, adapting, applying, maintaining... specially designed services for an infant or toddler with a disability and the family of such infant or... impartial mediator who is trained in effective mediation techniques. Medical services. Those evaluative...

Co-Teachers and Parents' Perceptions of Shortened Assignments for Learning Disabled Students

ERIC Educational Resources Information Center

Gutierrez, Yxstian

2013-01-01

The Individual with Disabilities in Education Act (IDEA) 2007, a federal special education law, states that students with disabilities requiring special education services can use accommodations or adaptations of the curriculum to access the general education curriculum. A shortened assignment, as an accommodation, can help learning disabled…

Adapting a Robot Hand to Specialized Functions

NASA Technical Reports Server (NTRS)

Clark, Keith H.

1987-01-01

Adaptor enables mechanical and electrical connections made easily between special-purpose end effector and arm of robot or remote mainpulator. Use in prosthetic devices also contemplatd. With adaptor, hand changed quickly from device designed to grasp objects of various sizes and shapes to device intended to do specific task efficiently.

Our Youngest Learners: The Infant School

ERIC Educational Resources Information Center

Grade Teacher, 1969

1969-01-01

An approach to teaching based on the English infant school where "youngsters aged from five to 10 work in specially adapted, child sized environments, doing whatever they want. Part of a longer special report which is available from: Grade Teacher Reprints, 23 Leroy Ave., Darien, Conn. 06820 (No. 91291, 75J) (Author/AP)

Cross-Cultural Concerns: What's Missing from Special Education Training Programs?

ERIC Educational Resources Information Center

Fox, C. Lynn; And Others

1988-01-01

A 12-step curriculum model for training inservice special education specialists who must also meet the needs of a culturally and linguistically diverse student population is proposed. The model follows the guidelines of Bloom's taxonomy for awareness, knowledge, and application. Suggestions for adaptation and implementation are also made. (MSE)

Manipulation of insect behavior with Specialized Pheromone & Lure Application Technology (SPLAT®)

Treesearch

Agenor Mafra-Neto; Frédérique M. de Lame; Christopher J. Fettig; A. Steven Munson; Thomas M. Perring; Lukasz L. Stelinski; Lyndsie Stoltman; Leandro E.J. Mafra; Rafael Borges; Roger I. Vargas

2013-01-01

SPLAT® (Specialized Pheromone and Lure Application Technology) emulsion is a unique controlled-release technology that can be adapted to dispense and protect a wide variety of compounds from degradation, including semiochemicals, pesticides, and phagostimulants, in diverse environments. ISCA Technologies, Inc., in collaboration with colleagues in academia, government,...

76 FR 36864 - Special Conditions: Gulfstream Model GVI Airplane; Operation Without Normal Electric Power

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-23

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 25 [Docket No. NM444; Special Conditions No. 25-435-SC] Special Conditions: Gulfstream Model GVI Airplane; Operation Without... rules (VFR) conditions for at least five minutes after loss of all normal electrical power. This rule...

Short-term differential adaptation to anaerobic stress via genomic mutations by Escherichia coli strains K-12 and B lacking alcohol dehydrogenase.

PubMed

Kim, Hyun Ju; Jeong, Haeyoung; Hwang, Seungwoo; Lee, Moo-Seung; Lee, Yong-Jik; Lee, Dong-Woo; Lee, Sang Jun

2014-01-01

Microbial adaptations often occur via genomic mutations under adverse environmental conditions. This study used Escherichia coli ΔadhE cells as a model system to investigate adaptation to anaerobic conditions, which we then compared with the adaptive mechanisms of two closely related E. coli strains, K-12 and B. In contrast to K-12 ΔadhE cells, the E. coli B ΔadhE cells exhibited significantly delayed adaptive growth under anaerobic conditions. Adaptation by the K-12 and B strains mainly employed anaerobic lactate fermentation to restore cellular growth. Several mutations were identified in the pta or pflB genes of adapted K-12 cells, but mostly in the pta gene of the B strains. However, the types of mutation in the adapted K-12 and B strains were similar. Cellular viability was affected directly by severe redox imbalance in B ΔadhE cells, which also impaired their ability to adapt to anaerobic conditions. This study demonstrates that closely related microorganisms may undergo different adaptations under the same set of adverse conditions, which might be associated with the specific metabolic characteristics of each strain. This study provides new insights into short-term microbial adaptation to stressful conditions, which may reflect dynamic microbial population changes in nature.

Natural variation in germination responses of Arabidopsis to seasonal cues and their associated physiological mechanisms

PubMed Central

Barua, Deepak; Butler, Colleen; Tisdale, Tracy E.; Donohue, Kathleen

2012-01-01

Background and Aims Despite the intense interest in phenological adaptation to environmental change, the fundamental character of natural variation in germination is almost entirely unknown. Specifically, it is not known whether different genotypes within a species are germination specialists to particular conditions, nor is it known what physiological mechanisms of germination regulation vary in natural populations and how they are associated with responses to particular environmental factors. Methods We used a set of recombinant inbred genotypes of Arabidopsis thaliana, in which linkage disequilibrium has been disrupted over seven generations, to test for genetic variation and covariation in germination responses to distinct environmental factors. We then examined physiological mechanisms associated with those responses, including seed-coat permeability and sensitivity to the phytohormones gibberellic acid (GA) and abscisic acid (ABA). Key Results Genetic variation for germination was environment-dependent, but no evidence for specialization of germination to different conditions was found. Hormonal sensitivities also exhibited significant genetic variation, but seed-coat properties did not. GA sensitivity was associated with germination responses to multiple environmental factors, but seed-coat permeability and ABA sensitivity were associated with specific germination responses, suggesting that an evolutionary change in GA sensitivity could affect germination in multiple environments, but that of ABA sensitivity may affect germination under more restricted conditions. Conclusions The physiological mechanisms of germination responses to specific environmental factors therefore can influence the ability to adapt to diverse seasonal environments encountered during colonization of new habitats or with future predicted climate change. PMID:22012958

The Role of Language-Game in Sociocultural Adaptation: Russian Students in France

ERIC Educational Resources Information Center

Sablina, Svetlana; Kopiatina, Olga

2013-01-01

Higher educational institutions throughout the world are involved in communication with each other, exchanging instructional ideas and practices, as well as exchanging students through a number of international mobility programs. This paper examines sociocultural adaptation of international students with special attention to the dimensions of…

Mutual Information Item Selection in Adaptive Classification Testing

ERIC Educational Resources Information Center

Weissman, Alexander

2007-01-01

A general approach for item selection in adaptive multiple-category classification tests is provided. The approach uses mutual information (MI), a special case of the Kullback-Leibler distance, or relative entropy. MI works efficiently with the sequential probability ratio test and alleviates the difficulties encountered with using other local-…

38 CFR 3.808 - Automobiles or other conveyances and adaptive equipment; certification.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 1 2014-07-01 2014-07-01 false Automobiles or other... Special Benefits § 3.808 Automobiles or other conveyances and adaptive equipment; certification. (a) Entitlement. A certificate of eligibility for financial assistance in the purchase of one automobile or other...

Leveling the Playing Field: Adapted PE Brings Together Kids with and without Disabilities.

ERIC Educational Resources Information Center

Jarrett, Denise

2000-01-01

Adapted physical education (APE) makes whatever adjustments are needed to allow students with disabilities to participate in regular physical education classes. APE at Beaverton School District (Oregon) is described, as well as the individualized special physical education classes provided to children with severe disabilities. (SV)

Care coordination for children with special needs in Medicaid: lessons from Medicare.

PubMed

Stewart, Kate A; Bradley, Katharine W V; Zickafoose, Joseph S; Hildrich, Rachel; Ireys, Henry T; Brown, Randall S

2018-04-01

To provide actionable recommendations for improving care coordination programs for children with special healthcare needs (CSHCN) in Medicaid managed care.  Literature review and interviews with stakeholders and policy experts to adapt lessons learned from Medicare care coordination programs for CSHCN in Medicaid managed care. We reviewed syntheses of research on Medicare care coordination programs to identify lessons learned from successful programs. We adapted findings from Medicare to CSHCN in Medicaid based on an environmental scan and discussions with experts. The scan focused on Medicaid financing and eligibility for care coordination and how these intersect with Medicaid managed care. The expert discussions included pediatricians, Medicaid policy experts, Medicaid medical directors, and a former managed care executive, all experienced in care coordination for CSHCN. We found 6 elements that are consistently associated with improved outcomes from Medicare care coordination programs and relevant to CSHCN in Medicaid: 1) identifying and targeting high-risk patients, 2) clearly articulating what outcomes programs are likely to improve, 3) encouraging active engagement between care coordinators and primary care providers, 4) requiring some in-person contact between care coordinators and patients, 5) facilitating information sharing among providers, and 6) supplementing care coordinators' expertise with that of other clinical experts. States and Medicaid managed care organizations have many options for designing effective care coordination programs for CSHCN. Their choices should account for the diversity of conditions among CSHCN, families' capacity to coordinate care, and social determinants of health.

On the roles of colour and scent in a specialized floral mimicry system

PubMed Central

Vereecken, Nicolas J.; Schiestl, Florian P.

2009-01-01

Background and Aims Sexually deceptive orchids achieve cross-pollination by mimicking the mating signals of female insects, generally hymenopterans. This pollination mechanism is often highly specific as it is based primarily on the mimicry of mating signals, especially the female sex pheromones of the targeted pollinator. Like many deceptive orchids, the Mediterranean species Ophrys arachnitiformis shows high levels of floral trait variation, especially in the colour of the perianth, which is either green or white/pinkinsh within populations. The adaptive significance of perianth colour polymorphism and its influence on pollinator visitation rates in sexually deceptive orchids remain obscure. Methods The relative importance of floral scent versus perianth colour in pollinator attraction in this orchid pollinator mimicry system was evaluated by performing floral scent analyses by gas chromatography-mass spectrometry (GC-MS) and behavioural bioassays with the pollinators under natural conditions were performed. Key Results The relative and absolute amounts of behaviourally active compounds are identical in the two colour morphs of O. arachnitiformis. Neither presence/absence nor the colour of the perianth (green versus white) influence attractiveness of the flowers to Colletes cunicularius males, the main pollinator of O. arachnitiformis. Conclusion Chemical signals alone can mediate the interactions in highly specialized mimicry systems. Floral colour polymorphism in O. arachnitiformis is not subjected to selection imposed by C. cunicularius males, and an interplay between different non-adaptive processes may be responsible for the maintenance of floral colour polymorphism both within and among populations. PMID:19692390

On the roles of colour and scent in a specialized floral mimicry system.

PubMed

Vereecken, Nicolas J; Schiestl, Florian P

2009-11-01

Sexually deceptive orchids achieve cross-pollination by mimicking the mating signals of female insects, generally hymenopterans. This pollination mechanism is often highly specific as it is based primarily on the mimicry of mating signals, especially the female sex pheromones of the targeted pollinator. Like many deceptive orchids, the Mediterranean species Ophrys arachnitiformis shows high levels of floral trait variation, especially in the colour of the perianth, which is either green or white/pinkinsh within populations. The adaptive significance of perianth colour polymorphism and its influence on pollinator visitation rates in sexually deceptive orchids remain obscure. The relative importance of floral scent versus perianth colour in pollinator attraction in this orchid pollinator mimicry system was evaluated by performing floral scent analyses by gas chromatography-mass spectrometry (GC-MS) and behavioural bioassays with the pollinators under natural conditions were performed. The relative and absolute amounts of behaviourally active compounds are identical in the two colour morphs of O. arachnitiformis. Neither presence/absence nor the colour of the perianth (green versus white) influence attractiveness of the flowers to Colletes cunicularius males, the main pollinator of O. arachnitiformis. Chemical signals alone can mediate the interactions in highly specialized mimicry systems. Floral colour polymorphism in O. arachnitiformis is not subjected to selection imposed by C. cunicularius males, and an interplay between different non-adaptive processes may be responsible for the maintenance of floral colour polymorphism both within and among populations.

The adaptation of Escherichia coli cells grown in simulated microgravity for an extended period is both phenotypic and genomic.

PubMed

Tirumalai, Madhan R; Karouia, Fathi; Tran, Quyen; Stepanov, Victor G; Bruce, Rebekah J; Ott, C Mark; Pierson, Duane L; Fox, George E

2017-01-01

Microorganisms impact spaceflight in a variety of ways. They play a positive role in biological systems, such as waste water treatment but can be problematic through buildups of biofilms that can affect advanced life support. Of special concern is the possibility that during extended missions, the microgravity environment will provide positive selection for undesirable genomic changes. Such changes could affect microbial antibiotic sensitivity and possibly pathogenicity. To evaluate this possibility, Escherichia coli (lac plus) cells were grown for over 1000 generations on Luria Broth medium under low-shear modeled microgravity conditions in a high aspect rotating vessel. This is the first study of its kind to grow bacteria for multiple generations over an extended period under low-shear modeled microgravity. Comparisons were made to a non-adaptive control strain using growth competitions. After 1000 generations, the final low-shear modeled microgravity-adapted strain readily outcompeted the unadapted lac minus strain. A portion of this advantage was maintained when the low-shear modeled microgravity strain was first grown in a shake flask environment for 10, 20, or 30 generations of growth. Genomic sequencing of the 1000 generation strain revealed 16 mutations. Of the five changes affecting codons, none were neutral. It is not clear how significant these mutations are as individual changes or as a group. It is concluded that part of the long-term adaptation to low-shear modeled microgravity is likely genomic. The strain was monitored for acquisition of antibiotic resistance by VITEK analysis throughout the adaptation period. Despite the evidence of genomic adaptation, resistance to a variety of antibiotics was never observed.

A synthesis of convergent reflections, tensions and silences in linking gender and global environmental change research.

PubMed

Iniesta-Arandia, Irene; Ravera, Federica; Buechler, Stephanie; Díaz-Reviriego, Isabel; Fernández-Giménez, María E; Reed, Maureen G; Thompson-Hall, Mary; Wilmer, Hailey; Aregu, Lemlem; Cohen, Philippa; Djoudi, Houria; Lawless, Sarah; Martín-López, Berta; Smucker, Thomas; Villamor, Grace B; Wangui, Elizabeth Edna

2016-12-01

This synthesis article joins the authors of the special issue "Gender perspectives in resilience, vulnerability and adaptation to global environmental change" in a common reflective dialogue about the main contributions of their papers. In sum, here we reflect on links between gender and feminist approaches to research in adaptation and resilience in global environmental change (GEC). The main theoretical contributions of this special issue are threefold: emphasizing the relevance of power relations in feminist political ecology, bringing the livelihood and intersectionality approaches into GEC, and linking resilience theories and critical feminist research. Empirical insights on key debates in GEC studies are also highlighted from the nine cases analysed, from Europe, the Americas, Asia, Africa and the Pacific. Further, the special issue also contributes to broaden the gender approach in adaptation to GEC by incorporating research sites in the Global North alongside sites from the Global South. This paper examines and compares the main approaches adopted (e.g. qualitative or mixed methods) and the methodological challenges that derive from intersectional perspectives. Finally, key messages for policy agendas and further research are drawn from the common reflection.

Design and adaptation of a novel supercritical extraction facility for operation in a glove box for recovery of radioactive elements

NASA Astrophysics Data System (ADS)

Kumar, V. Suresh; Kumar, R.; Sivaraman, N.; Ravisankar, G.; Vasudeva Rao, P. R.

2010-09-01

The design and development of a novel supercritical extraction experimental facility adapted for safe operation in a glove box for the recovery of radioactive elements from waste is described. The apparatus incorporates a high pressure extraction vessel, reciprocating pumps for delivering supercritical fluid and reagent, a back pressure regulator, and a collection chamber. All these components of the system have been specially designed for glove box adaptation and made modular to facilitate their replacement. Confinement of these materials must be ensured in a glove box to protect the operator and prevent contamination to the work area. Since handling of radioactive materials under high pressure (30 MPa) and temperature (up to 333 K) is involved in this process, the apparatus needs elaborate safety features in the design of the equipment, as well as modification of a standard glove box to accommodate the system. As a special safety feature to contain accidental leakage of carbon dioxide from the extraction vessel, a safety vessel has been specially designed and placed inside the glove box. The extraction vessel was enclosed in the safety vessel. The safety vessel was also incorporated with pressure sensing and controlling device.

78 FR 55629 - Special Conditions: Cirrus Design Corporation, Model SF50; Inflatable Three-Point Restraint...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-11

...-0781; Special Conditions No. 23-261-SC] Special Conditions: Cirrus Design Corporation, Model SF50... conditions are issued for the Cirrus Design Corporation (Cirrus), model SF50. This airplane will have novel and unusual design features associated with installation of an inflatable three-point restraint safety...

76 FR 62603 - Special Conditions: The Boeing Company, Model 747-8; Upper Deck Occupancy

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-11

... Conditions No. 25-446-SC] Special Conditions: The Boeing Company, Model 747-8; Upper Deck Occupancy AGENCY.... SUMMARY: These special conditions are issued for the Boeing Model 747-8 airplane. These airplanes will... airworthiness regulations do not contain adequate or appropriate safety standards for this design feature. These...

Adaptive functioning and behaviour problems in relation to level of education in children and adolescents with intellectual disability.

PubMed

de Bildt, A; Sytema, S; Kraijer, D; Sparrow, S; Minderaa, R

2005-09-01

The interrelationship between adaptive functioning, behaviour problems and level of special education was studied in 186 children with IQs ranging from 61 to 70. The objective was to increase the insight into the contribution of adaptive functioning and general and autistic behaviour problems to the level of education in children with intellectual disability (ID). Children from two levels of special education in the Netherlands were compared with respect to adaptive functioning [Vineland Adaptive Behavior Scales (VABS)], general behaviour problems [Child Behavior Checklist (CBCL)] and autistic behaviour problems [Autism Behavior Checklist (ABC)]. The effect of behaviour problems on adaptive functioning, and the causal relationships between behaviour problems, adaptive functioning and level of education were investigated. Children in schools for mild learning problems had higher VABS scores, and lower CBCL and ABC scores. The ABC had a significant effect on the total age equivalent of the VABS in schools for severe learning problems, the CBCL in schools for mild learning problems. A direct effect of the ABC and CBCL total scores on the VABS age equivalent was found, together with a direct effect of the VABS age equivalent on level of education and therefore an indirect effect of ABC and CBCL on level of education. In the children with the highest level of mild ID, adaptive functioning seems to be the most important factor that directly influences the level of education that a child attends. Autistic and general behaviour problems directly influence the level of adaptive functioning. Especially, autistic problems seem to have such a restrictive effect on the level of adaptive functioning that children do not reach the level of education that would be expected based on IQ. Clinical implications are discussed.

Selected remarks about anticipation in instrumental civilization subsystems

NASA Astrophysics Data System (ADS)

Adamkiewicz, Wiktor H.

2001-06-01

The paper contains a fragment of research description dealing with social systems saturated with technology products. The aim of this research is to determine the possibility to predict the influence of changes in the system on the process leading to the adaptation to the environment. The adaptation process is an activity based on anticipation of the future system states and environment states. Therefore, it is essential to determine the relationships existing between these two sets of states. Research results should determine the efficiency level of anticipating activity. Many processes take place in the system and its environment. Simultaneous research on all processes allows to specify the effect of synergy whose form determines adaptation. Researching all processes is not possible, though. Therefore, it is necessary to use appropriate models. Such models may be created by applying general rule of system approach. Nowadays, social systems must adapt to the increasing pace of globalization involving products, markets, competition and finance. The ability to adapt the system to the global situation is the condition for survival and possible development. Thus, the conformity of development and global situation is the superior aim of anticipation. Many experts deal with research on social systems. Many of them represent the humanities. We cannot expect them to undertake special mathematical studies. However, such research requires analysing various sets of figures. The ability to formulate tasks for mathematicians and the ability to use the results of figure analyses are essential. Therefore, the author makes certain suggestions referring to the application of mathematics in the research which may be accepted by the humanities' scholars. (Adamkiewicz, 1999d). The author hopes so.

Specialized Functional Diversity and Interactions of the Na,K-ATPase

PubMed Central

Matchkov, Vladimir V.; Krivoi, Igor I.

2016-01-01

Na,K-ATPase is a protein ubiquitously expressed in the plasma membrane of all animal cells and vitally essential for their functions. A specialized functional diversity of the Na,K-ATPase isozymes is provided by molecular heterogeneity, distinct subcellular localizations, and functional interactions with molecular environment. Studies over the last decades clearly demonstrated complex and isoform-specific reciprocal functional interactions between the Na,K-ATPase and neighboring proteins and lipids. These interactions are enabled by a spatially restricted ion homeostasis, direct protein-protein/lipid interactions, and protein kinase signaling pathways. In addition to its “classical” function in ion translocation, the Na,K-ATPase is now considered as one of the most important signaling molecules in neuronal, epithelial, skeletal, cardiac and vascular tissues. Accordingly, the Na,K-ATPase forms specialized sub-cellular multimolecular microdomains which act as receptors to circulating endogenous cardiotonic steroids (CTS) triggering a number of signaling pathways. Changes in these endogenous cardiotonic steroid levels and initiated signaling responses have significant adaptive values for tissues and whole organisms under numerous physiological and pathophysiological conditions. This review discusses recent progress in the studies of functional interactions between the Na,K-ATPase and molecular microenvironment, the Na,K-ATPase-dependent signaling pathways and their significance for diversity of cell function. PMID:27252653

Preprocessing of PHERMEX flash radiographic images with Haar and adaptive filtering

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brolley, J.E.

1978-11-01

Work on image preparation has continued with the application of high-sequency boosting via Haar filtering. This is useful in developing line or edge structures. Widrow LMS adaptive filtering has also been shown to be useful in developing edge structure in special problems. Shadow effects can be obtained with the latter which may be useful for some problems. Combined Haar and adaptive filtering is illustrated for a PHERMEX image.

Adaptive Meshing Techniques for Viscous Flow Calculations on Mixed Element Unstructured Meshes

NASA Technical Reports Server (NTRS)

Mavriplis, D. J.

1997-01-01

An adaptive refinement strategy based on hierarchical element subdivision is formulated and implemented for meshes containing arbitrary mixtures of tetrahendra, hexahendra, prisms and pyramids. Special attention is given to keeping memory overheads as low as possible. This procedure is coupled with an algebraic multigrid flow solver which operates on mixed-element meshes. Inviscid flows as well as viscous flows are computed an adaptively refined tetrahedral, hexahedral, and hybrid meshes. The efficiency of the method is demonstrated by generating an adapted hexahedral mesh containing 3 million vertices on a relatively inexpensive workstation.

Introduction to a Special Issue Dialectical Behavior Therapy: Evolution and Adaptations in the 21(st) Century.

PubMed

Miller, Alec L

2015-01-01

Born from the randomized controlled trial by Linehan and colleagues in 1991, dialectical behavior therapy (DBT) has become the gold standard for treatment of individuals who are suicidal and have borderline personality disorder. In this special issue, we begin with a historical review of DBT provided by the treatment developer herself. We then introduce readers to new, 21(st) century adaptations developed of this treatment modality. In this issue we explore the use of DBT for suicidal adolescents with one paper focusing on Latina teens and their parents, and one focused on the more recently developed walking the middle path skills module. Other papers in this issue include unique adaptations of DBT for eating disorders, and disorders of over-control, as well as trauma in incarcerated male adolescents. We also look at transdiagnostic applications of DBT and finally a comparison of DBT with mentalization-based treatment.

Short-term differential adaptation to anaerobic stress via genomic mutations by Escherichia coli strains K-12 and B lacking alcohol dehydrogenase

PubMed Central

Kim, Hyun Ju; Jeong, Haeyoung; Hwang, Seungwoo; Lee, Moo-Seung; Lee, Yong-Jik; Lee, Dong-Woo; Lee, Sang Jun

2014-01-01

Microbial adaptations often occur via genomic mutations under adverse environmental conditions. This study used Escherichia coli ΔadhE cells as a model system to investigate adaptation to anaerobic conditions, which we then compared with the adaptive mechanisms of two closely related E. coli strains, K-12 and B. In contrast to K-12 ΔadhE cells, the E. coli B ΔadhE cells exhibited significantly delayed adaptive growth under anaerobic conditions. Adaptation by the K-12 and B strains mainly employed anaerobic lactate fermentation to restore cellular growth. Several mutations were identified in the pta or pflB genes of adapted K-12 cells, but mostly in the pta gene of the B strains. However, the types of mutation in the adapted K-12 and B strains were similar. Cellular viability was affected directly by severe redox imbalance in B ΔadhE cells, which also impaired their ability to adapt to anaerobic conditions. This study demonstrates that closely related microorganisms may undergo different adaptations under the same set of adverse conditions, which might be associated with the specific metabolic characteristics of each strain. This study provides new insights into short-term microbial adaptation to stressful conditions, which may reflect dynamic microbial population changes in nature. PMID:25250024

Mobile Learning Technology Based on iOS Devices to Support Students with Special Education Needs

ERIC Educational Resources Information Center

Fernandez-Lopez, Alvaro; Rodriguez-Fortiz, Maria Jose; Rodriguez-Almendros, Maria Luisa; Martinez-Segura, Maria Jose

2013-01-01

Students with special education have difficulties to develop cognitive abilities and acquire new knowledge. They could also need to improve their behavior, communication and relationships with their environment. The development of customizable and adaptable applications tailored to them provides many benefits as it helps mold the learning process…

Students with Special Educational Needs and Assistive Technologies: A Literature Review

ERIC Educational Resources Information Center

Erdem, Raziye

2017-01-01

The term "assistive technologies" refers to the equipment, devices and apparatus, and the services, systems, processes and adaptations made to the environment that support and facilitate their functions, used by persons with special education needs. This study is a literature review of the use of assistive technologies in the education…

75 FR 20516 - Special Conditions: Cirrus Design Corporation, Model SF50; Fire Extinguishing for Upper Aft...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-20

...; Special Conditions No. 23-245-SC] Special Conditions: Cirrus Design Corporation, Model SF50; Fire... protect such installed engines from fires, were not envisioned in the development of the part 23 normal... condition for the fire extinguishing system for the engine on the model SF50 is required. Regulations...

Evolution of Self-Organized Task Specialization in Robot Swarms

PubMed Central

Ferrante, Eliseo; Turgut, Ali Emre; Duéñez-Guzmán, Edgar; Dorigo, Marco; Wenseleers, Tom

2015-01-01

Division of labor is ubiquitous in biological systems, as evidenced by various forms of complex task specialization observed in both animal societies and multicellular organisms. Although clearly adaptive, the way in which division of labor first evolved remains enigmatic, as it requires the simultaneous co-occurrence of several complex traits to achieve the required degree of coordination. Recently, evolutionary swarm robotics has emerged as an excellent test bed to study the evolution of coordinated group-level behavior. Here we use this framework for the first time to study the evolutionary origin of behavioral task specialization among groups of identical robots. The scenario we study involves an advanced form of division of labor, common in insect societies and known as “task partitioning”, whereby two sets of tasks have to be carried out in sequence by different individuals. Our results show that task partitioning is favored whenever the environment has features that, when exploited, reduce switching costs and increase the net efficiency of the group, and that an optimal mix of task specialists is achieved most readily when the behavioral repertoires aimed at carrying out the different subtasks are available as pre-adapted building blocks. Nevertheless, we also show for the first time that self-organized task specialization could be evolved entirely from scratch, starting only from basic, low-level behavioral primitives, using a nature-inspired evolutionary method known as Grammatical Evolution. Remarkably, division of labor was achieved merely by selecting on overall group performance, and without providing any prior information on how the global object retrieval task was best divided into smaller subtasks. We discuss the potential of our method for engineering adaptively behaving robot swarms and interpret our results in relation to the likely path that nature took to evolve complex sociality and task specialization. PMID:26247819

Evolution of Self-Organized Task Specialization in Robot Swarms.

PubMed

Ferrante, Eliseo; Turgut, Ali Emre; Duéñez-Guzmán, Edgar; Dorigo, Marco; Wenseleers, Tom

2015-08-01

Division of labor is ubiquitous in biological systems, as evidenced by various forms of complex task specialization observed in both animal societies and multicellular organisms. Although clearly adaptive, the way in which division of labor first evolved remains enigmatic, as it requires the simultaneous co-occurrence of several complex traits to achieve the required degree of coordination. Recently, evolutionary swarm robotics has emerged as an excellent test bed to study the evolution of coordinated group-level behavior. Here we use this framework for the first time to study the evolutionary origin of behavioral task specialization among groups of identical robots. The scenario we study involves an advanced form of division of labor, common in insect societies and known as "task partitioning", whereby two sets of tasks have to be carried out in sequence by different individuals. Our results show that task partitioning is favored whenever the environment has features that, when exploited, reduce switching costs and increase the net efficiency of the group, and that an optimal mix of task specialists is achieved most readily when the behavioral repertoires aimed at carrying out the different subtasks are available as pre-adapted building blocks. Nevertheless, we also show for the first time that self-organized task specialization could be evolved entirely from scratch, starting only from basic, low-level behavioral primitives, using a nature-inspired evolutionary method known as Grammatical Evolution. Remarkably, division of labor was achieved merely by selecting on overall group performance, and without providing any prior information on how the global object retrieval task was best divided into smaller subtasks. We discuss the potential of our method for engineering adaptively behaving robot swarms and interpret our results in relation to the likely path that nature took to evolve complex sociality and task specialization.

Non-decoupled morphological evolution of the fore- and hindlimb of sabretooth predators.

PubMed

Martín-Serra, Alberto; Figueirido, Borja; Palmqvist, Paul

2017-10-01

Specialized organisms are useful for exploring the combined effects of selection of functional traits and developmental constraints on patterns of phenotypic integration. Sabretooth predators are one of the most interesting examples of specialization among mammals. Their hypertrophied, sabre-shaped upper canines and their powerfully built forelimbs have been interpreted as adaptations to a highly specialized predatory behaviour. Given that the elongated and laterally compressed canines of sabretooths were more vulnerable to fracture than the shorter canines of conical-tooth cats, it has been long hypothesized that the heavily muscled forelimbs of sabretooths were used for immobilizing prey before developing a quick and precise killing bite. However, the effect of this unique adaptation on the covariation between the fore- and the hindlimb has not been explored in a quantitative fashion. In this paper, we investigate if the specialization of sabretooth predators decoupled the morphological variation of their forelimb with respect to their hindlimb or, in contrast, both limbs vary in the same fashion as in conical-tooth cats, which do not show such extreme adaptations in their forelimb. We use 3D geometric morphometrics and different morphological indices to compare the fore- and hindlimb of conical- and sabretooth predators. Our results indicate that the limb bones of sabretooth predators covary following the same trend of conical-tooth cats. Therefore, we show that the predatory specialization of sabretooth predators did not result in a decoupling of the morphological evolution of their fore- and hindlimbs. The role of developmental constraints and natural selection on this coordinate variation between the fore- and the hindlimb is discussed in the light of this new evidence. © 2017 Anatomical Society.

Intra-plastid protein trafficking: how plant cells adapted prokaryotic mechanisms to the eukaryotic condition.

PubMed

Celedon, Jose M; Cline, Kenneth

2013-02-01

Protein trafficking and localization in plastids involve a complex interplay between ancient (prokaryotic) and novel (eukaryotic) translocases and targeting machineries. During evolution, ancient systems acquired new functions and novel translocation machineries were developed to facilitate the correct localization of nuclear encoded proteins targeted to the chloroplast. Because of its post-translational nature, targeting and integration of membrane proteins posed the biggest challenge to the organelle to avoid aggregation in the aqueous compartments. Soluble proteins faced a different kind of problem since some had to be transported across three membranes to reach their destination. Early studies suggested that chloroplasts addressed these issues by adapting ancient-prokaryotic machineries and integrating them with novel-eukaryotic systems, a process called 'conservative sorting'. In the last decade, detailed biochemical, genetic, and structural studies have unraveled the mechanisms of protein targeting and localization in chloroplasts, suggesting a highly integrated scheme where ancient and novel systems collaborate at different stages of the process. In this review we focus on the differences and similarities between chloroplast ancestral translocases and their prokaryotic relatives to highlight known modifications that adapted them to the eukaryotic situation. This article is part of a Special Issue entitled: Protein Import and Quality Control in Mitochondria and Plastids. Copyright © 2012 Elsevier B.V. All rights reserved.

Salinity Tolerance Mechanism of Economic Halophytes From Physiological to Molecular Hierarchy for Improving Food Quality

PubMed Central

Xu, Chongzhi; Tang, Xiaoli; Shao, Hongbo; Wang, Hongyan

2016-01-01

Soil salinity is becoming the key constraints factor to agricultural production. Therefore, the plant especially the crops possessing capacities of salt tolerance will be of great economic significance. The adaptation or tolerance of plant to salinity stress involves a series of physiological, metabolic and molecular mechanisms. Halophytes are the kind of organisms which acquire special salt tolerance mechanisms to respond to the salt tress and ensure normal growth and development under saline conditions in their lengthy evolutionary adaptation, so understanding how halophytes respond to salinity stress will provide us with methods and tactics to foster and develop salt resistant varieties of crops. The strategies in physiological and molecular level adopted by halophytes are various including the changes in photosynthetic and transpiration rate, the sequestration of Na+ to extracellular or vacuole, the regulation of stomata aperture and stomatal density, the accumulation and synthesis of the phytohormones as well as the relevant gene expression underlying these physiological traits, such as the stress signal transduction, the regulation of the transcription factors, the activation and expression of the transporter genes, the activation or inhibition of the synthetases and so on. This review focuses on the research advances of the regulating mechanisms in halophytes from physiological to molecular, which render the halophytes tolerance and adaption to salinity stress. PMID:27252587

Climate Change and Water Infrastructure in Central Asia: adaptation capacities and institutional challenges

NASA Astrophysics Data System (ADS)

Abdullaev, Iskandar; Rakhmatullaev, Shavkat

2014-05-01

The paper discusses vulnerability areas of water sector in arid Central Asia due to climate change projections with particular focus on adaptation to sustainable operation of physical infrastructure capacities (from legal, institutional and technical aspects). Two types of technical installations are the main focus of this paper, i.e., electrical lift irrigation systems and water reservoirs. The first set of electrical lift infrastructure is strategic for delivering water to water users via pumps, diversion structures, vertical drainage facilities and groundwater boreholes; on the other hand, the primarily task of second set of structures is to accumulate the water resources for sectors of economy. In Central Asia, approximately, 20-50% of irrigation water is lifted, yet major of lift structures are in very poor technical conditions coupled with ever increasing of electricity tariffs. Furthermore, useful volumes capacities of water reservoirs are being severely diminished due to bio-physical geomorphologic processes, improper operational regimes and chronic financing for special in-house sedimentation surveys. Most importantly, the key argument is that irrigation sector should internalize its adaptation efforts, i.e., integrate renewable energy technologies, energy audit programs and lastly design comprehensive investment prioritization processes and programs. Otherwise, water sector will be at great risk for continued provision of fundamental services to the public, food security and industry

Regime shifts and panarchies in regional scale social ...

EPA Pesticide Factsheets

In this article we summarize histories of nonlinear, complex interactions among societal, legal, and ecosystem dynamics in six North American water basins, as they respond to changing climate. These case studies were chosen to explore the conditions for emergence of adaptive governance in heavily regulated and developed social-ecological systems nested within a hierarchical governmental system. We summarize resilience assessments conducted in each system to provide a synthesis and reference by the other articles in this special feature. We also present a general framework used to evaluate the interactions between society and ecosystem regimes and the governance regimes chosen to mediate those interactions. The case studies show different ways that adaptive governance may be triggered, facilitated, or constrained by ecological and/or legal processes. The resilience assessments indicate that complex interactions among the governance and ecosystem components of these systems can produce different trajectories, which include patterns of (a) development and stabilization, (b) cycles of crisis and recovery, which includes lurches in adaptation and learning, and (3) periods of innovation, novelty, and transformation. Exploration of cross scale (Panarchy) interactions among levels and sectors of government and society illustrate that they may constrain development trajectories, but may also provide stability during crisis or innovation at smaller scales; create crises,

A problem-solving task specialized for functional neuroimaging: validation of the Scarborough adaptation of the Tower of London (S-TOL) using near-infrared spectroscopy

PubMed Central

Ruocco, Anthony C.; Rodrigo, Achala H.; Lam, Jaeger; Di Domenico, Stefano I.; Graves, Bryanna; Ayaz, Hasan

2014-01-01

Problem-solving is an executive function subserved by a network of neural structures of which the dorsolateral prefrontal cortex (DLPFC) is central. Whereas several studies have evaluated the role of the DLPFC in problem-solving, few standardized tasks have been developed specifically for use with functional neuroimaging. The current study adapted a measure with established validity for the assessment of problem-solving abilities to design a test more suitable for functional neuroimaging protocols. The Scarborough adaptation of the Tower of London (S-TOL) was administered to 38 healthy adults while hemodynamic oxygenation of the PFC was measured using 16-channel continuous-wave functional near-infrared spectroscopy (fNIRS). Compared to a baseline condition, problems that required two or three steps to achieve a goal configuration were associated with higher activation in the left DLPFC and deactivation in the medial PFC. Individuals scoring higher in trait deliberation showed consistently higher activation in the left DLPFC regardless of task difficulty, whereas individuals lower in this trait displayed less activation when solving simple problems. Based on these results, the S-TOL may serve as a standardized task to evaluate problem-solving abilities in functional neuroimaging studies. PMID:24734017

Orthonormal filters for identification in active control systems

NASA Astrophysics Data System (ADS)

Mayer, Dirk

2015-12-01

Many active noise and vibration control systems require models of the control paths. When the controlled system changes slightly over time, adaptive digital filters for the identification of the models are useful. This paper aims at the investigation of a special class of adaptive digital filters: orthonormal filter banks possess the robust and simple adaptation of the widely applied finite impulse response (FIR) filters, but at a lower model order, which is important when considering implementation on embedded systems. However, the filter banks require prior knowledge about the resonance frequencies and damping of the structure. This knowledge can be supposed to be of limited precision, since in many practical systems, uncertainties in the structural parameters exist. In this work, a procedure using a number of training systems to find the fixed parameters for the filter banks is applied. The effect of uncertainties in the prior knowledge on the model error is examined both with a basic example and in an experiment. Furthermore, the possibilities to compensate for the imprecise prior knowledge by a higher filter order are investigated. Also comparisons with FIR filters are implemented in order to assess the possible advantages of the orthonormal filter banks. Numerical and experimental investigations show that significantly lower computational effort can be reached by the filter banks under certain conditions.

Coregulation of host-adapted metabolism and virulence by pathogenic yersiniae

PubMed Central

Heroven, Ann Kathrin; Dersch, Petra

2014-01-01

Deciphering the principles how pathogenic bacteria adapt their metabolism to a specific host microenvironment is critical for understanding bacterial pathogenesis. The enteric pathogenic Yersinia species Yersinia pseudotuberculosis and Yersinia enterocolitica and the causative agent of plague, Yersinia pestis, are able to survive in a large variety of environmental reservoirs (e.g., soil, plants, insects) as well as warm-blooded animals (e.g., rodents, pigs, humans) with a particular preference for lymphatic tissues. In order to manage rapidly changing environmental conditions and interbacterial competition, Yersinia senses the nutritional composition during the course of an infection by special molecular devices, integrates this information and adapts its metabolism accordingly. In addition, nutrient availability has an impact on expression of virulence genes in response to C-sources, demonstrating a tight link between the pathogenicity of yersiniae and utilization of nutrients. Recent studies revealed that global regulatory factors such as the cAMP receptor protein (Crp) and the carbon storage regulator (Csr) system are part of a large network of transcriptional and posttranscriptional control strategies adjusting metabolic changes and virulence in response to temperature, ion and nutrient availability. Gained knowledge about the specific metabolic requirements and the correlation between metabolic and virulence gene expression that enable efficient host colonization led to the identification of new potential antimicrobial targets. PMID:25368845

The red-cockaded woodpecker cavity tree: A very special pine

Treesearch

Richard N. Conner; D. Craig Rudolph; Daniel Saenz; Robert H. Johnson

2004-01-01

The adaptation of red-cockaded woodpeckers (Picoides borealis) to fire-maintained southern pine ecosystems has included the development of behaviors that permit the species to use living pines for their cavity trees. Their adaptation to pine ecosystems has also involved a major adjustment in the species' breeding system to cooperative breeding,...

The Adaptive Basis of Psychosocial Acceleration: Comment on beyond Mental Health, Life History Strategies Articles

ERIC Educational Resources Information Center

Nettle, Daniel; Frankenhuis, Willem E.; Rickard, Ian J.

2012-01-01

Four of the articles published in this special section of "Developmental Psychology" build on and refine psychosocial acceleration theory. In this short commentary, we discuss some of the adaptive assumptions of psychosocial acceleration theory that have not received much attention. Psychosocial acceleration theory relies on the behavior of…

MONITORING METHODS ADAPTABLE TO VAPOR INTRUSION MONITORING - USEPA COMPENDIUM METHODS TO-15, TO-15 SUPPLEMENT (DRAFT), AND TO-17

EPA Science Inventory

USEPA ambient air monitoring methods for volatile organic compounds (VOCs) using specially-prepared canisters and solid adsorbents are directly adaptable to monitoring for vapors in the indoor environment. The draft Method TO-15 Supplement, an extension of the USEPA Method TO-15,...

Including Exceptional Students in Your Instrumental Music Program

ERIC Educational Resources Information Center

Mixon, Kevin

2005-01-01

This article describes the method and adaptations used by the author in including students with special needs in an instrumental music program. To ensure success in the program, the author shares the method he uses to include exceptional students and enumerates some possible adaptations. There are certainly other methods and modifications that…

Evolution of Brain and Language

ERIC Educational Resources Information Center

Schoenemann, P. Thomas

2009-01-01

The evolution of language and the evolution of the brain are tightly interlinked. Language evolution represents a special kind of adaptation, in part because language is a complex behavior (as opposed to a physical feature) but also because changes are adaptive only to the extent that they increase either one's understanding of others, or one's…

Adaptive Behavior Assessment and the Implementation of P.L. 94-142.

ERIC Educational Resources Information Center

Scott, Leigh S.

Assessment of the adaptive behavior of public school children being considered for placement in the special education programs for the mentally handicapped in the Corpus Christi (Texas) Independent School District (CCISD) is discussed. Formal and informal assessment procedures are used, with a team of two associate school psychologists having the…

The Constitution of the United States (Adapted). For Use in EMR Classes.

ERIC Educational Resources Information Center

Miller, Louise A.

This special instructional handbook presents a unit of study on the United States Constitution for educable mentally retarded students at the secondary level. The adapted material explains the structure of the national government, and is designed to promote citizenship and patriotic values. Preliminary information includes a glossary of new words,…

[Preface to special issue: "Molecular mechanism of the adaptation of terrestrial plants to gravity environment on Earth"].

PubMed

Kamisaka, Seiichiro

2003-08-01

Organisms borne in the primitive sea about 30 million years ago had evolved in water without a large influence of gravity on earth. About 4 million years ago, the first terrestrial organisms, plants appeared on the land from the sea. The terrestrial plants have adapted to and evolved on the land environment so that they can extend their roots downward in soil and their shoots upward against 1 g gravity. At least two functions that were acquired during the process of evolution helped the terrestrial plants to adapt to gravity environment on earth. One is gravitropism. The other is the reinforcement of the cell wall, particularly the secondary cell wall. In the present feature articles, the molecular mechanism of the adaptation of terrestrial plants to gravity environment on earth will be reviewed, paying special attention to the mechanism of the genetic control of the signaling of gravity stimulus in gravitropism, automorphogenesis, genes involved in auxin transport, gravity effect on cell wall properties and gravimorphogenesis in terrestrial plants.

Evolution of complex adaptations in molecular systems

PubMed Central

Pál, Csaba; Papp, Balázs

2017-01-01

A central challenge in evolutionary biology concerns the mechanisms by which complex adaptations arise. Such adaptations depend on the fixation of multiple, highly specific mutations, where intermediate stages of evolution seemingly provide little or no benefit. It is generally assumed that the establishment of complex adaptations is very slow in nature, as evolution of such traits demands special population genetic or environmental circumstances. However, blueprints of complex adaptations in molecular systems are pervasive, indicating that they can readily evolve. We discuss the prospects and limitations of non-adaptive scenarios, which assume multiple neutral or deleterious steps in the evolution of complex adaptations. Next, we examine how complex adaptations can evolve by natural selection in changing environment. Finally, we argue that molecular ’springboards’, such as phenotypic heterogeneity and promiscuous interactions facilitate this process by providing access to new adaptive paths. PMID:28782044

Sun/shade conditions affect recruitment and local adaptation of a columnar cactus in dry forests.

PubMed

Miranda-Jácome, Antonio; Montaña, Carlos; Fornoni, Juan

2013-02-01

Facilitation among plants in water-limited environments (i.e. where evapotranspiration overcomes the availability of water during the growing season) has been considered a local adaptation to water and light conditions. Among cacti, early life-history stages can benefit from the facilitative effects of nurse plants that reduce solar radiation and water stress. However, whether light condition itself acts as an agent of selection through facilitation remains untested. The aim of this study was to determine (1) whether light conditions affect seedling recruitment, (2) whether the positive effect of shade on seedling recruitment is more intense under more stressful conditions and (3) whether shade condition (facilitation) reduces the magnitude of local adaptation on seedling recruitment relative to full sunlight conditions. A reciprocal transplant experiment, coupled with the artificial manipulation of sun/shade conditions, was performed to test for the effects of local adaptation on germination, seedling survival and growth, using two demes of the columnar cactus Pilosocereus leucocephalus, representing different intensities of stressful conditions. Full sunlight conditions reduced recruitment success and supported the expectation of lower recruitment in more stressful environments. Significant local adaptation was mainly detected under full sunlight conditions, indicating that this environmental factor acts as an agent of selection at both sites. The results supported the expectation that the magnitude of local adaptation, driven by the effects of facilitative nurse plants, is less intense under reduced stressful conditions. This study is the first to demonstrate that sun/shade conditions act as a selective agent accounting for local adaptation in water-limited environments, and that facilitation provided by nurse plants in these environments can attenuate the patterns of local adaptation among plants benefiting from the nurse effect.

Sun/shade conditions affect recruitment and local adaptation of a columnar cactus in dry forests

PubMed Central

Miranda-Jácome, Antonio; Montaña, Carlos; Fornoni, Juan

2013-01-01

Background and Aims Facilitation among plants in water-limited environments (i.e. where evapotranspiration overcomes the availability of water during the growing season) has been considered a local adaptation to water and light conditions. Among cacti, early life-history stages can benefit from the facilitative effects of nurse plants that reduce solar radiation and water stress. However, whether light condition itself acts as an agent of selection through facilitation remains untested. The aim of this study was to determine (1) whether light conditions affect seedling recruitment, (2) whether the positive effect of shade on seedling recruitment is more intense under more stressful conditions and (3) whether shade condition (facilitation) reduces the magnitude of local adaptation on seedling recruitment relative to full sunlight conditions. Methods A reciprocal transplant experiment, coupled with the artificial manipulation of sun/shade conditions, was performed to test for the effects of local adaptation on germination, seedling survival and growth, using two demes of the columnar cactus Pilosocereus leucocephalus, representing different intensities of stressful conditions. Key Results Full sunlight conditions reduced recruitment success and supported the expectation of lower recruitment in more stressful environments. Significant local adaptation was mainly detected under full sunlight conditions, indicating that this environmental factor acts as an agent of selection at both sites. Conclusions The results supported the expectation that the magnitude of local adaptation, driven by the effects of facilitative nurse plants, is less intense under reduced stressful conditions. This study is the first to demonstrate that sun/shade conditions act as a selective agent accounting for local adaptation in water-limited environments, and that facilitation provided by nurse plants in these environments can attenuate the patterns of local adaptation among plants benefiting from the nurse effect. PMID:23223204

Insects as a Nitrogen Source for Plants

PubMed Central

Behie, Scott W.; Bidochka, Michael J.

2013-01-01

Many plants have evolved adaptations in order to survive in low nitrogen environments. One of the best-known adaptations is that of plant symbiosis with nitrogen-fixing bacteria; this is the major route by which nitrogen is incorporated into plant biomass. A portion of this plant-associated nitrogen is then lost to insects through herbivory, and insects represent a nitrogen reservoir that is generally overlooked in nitrogen cycles. In this review we show three specialized plant adaptations that allow for the recovery of insect nitrogen; that is, plants gaining nitrogen from insects. First, we show specialized adaptations by carnivorous plants in low nitrogen habitats. Insect carnivorous plants such as pitcher plants and sundews (Nepenthaceae/Sarraceniaceae and Drosera respectively) are able to obtain substantial amounts of nitrogen from the insects that they capture. Secondly, numerous plants form associations with mycorrhizal fungi that can provide soluble nitrogen from the soil, some of which may be insect-derived nitrogen, obtained from decaying insects or insect frass. Finally, a specialized group of endophytic, insect-pathogenic fungi (EIPF) provide host plants with insect-derived nitrogen. These soil-inhabiting fungi form a remarkable symbiosis with certain plant species. They can infect a wide range of insect hosts and also form endophytic associations in which they transfer insect-derived nitrogen to the plant. Root colonizing fungi are found in disparate fungal phylogenetic lineages, indicating possible convergent evolutionary strategies between taxa, evolution potentially driven by access to carbon-containing root exudates. PMID:26462427

Functional specialization in regulation and quality control in thermal adaptive evolution.

PubMed

Yama, Kazuma; Matsumoto, Yuki; Murakami, Yoshie; Seno, Shigeto; Matsuda, Hideo; Gotoh, Kazuyoshi; Motooka, Daisuke; Nakamura, Shota; Ying, Bei-Wen; Yomo, Tetsuya

2015-11-01

Distinctive survival strategies, specialized in regulation and in quality control, were observed in thermal adaptive evolution with a laboratory Escherichia coli strain. The two specialists carried a single mutation either within rpoH or upstream of groESL, which led to the activated global regulation by sigma factor 32 or an increased amount of GroEL/ES chaperonins, respectively. Although both specialists succeeded in thermal adaptation, the common winner of the evolution was the specialist in quality control, that is, the strategy of chaperonin-mediated protein folding. To understand this evolutionary consequence, multilevel analyses of cellular status, for example, transcriptome, protein and growth fitness, were carried out. The specialist in quality control showed less change in transcriptional reorganization responding to temperature increase, which was consistent with the finding of that the two specialists showed the biased expression of molecular chaperones. Such repressed changes in gene expression seemed to be advantageous for long-term sustainability because a specific increase in chaperonins not only facilitated the folding of essential gene products but also saved cost in gene expression compared with the overall transcriptional increase induced by rpoH regulation. Functional specialization offered two strategies for successful thermal adaptation, whereas the evolutionary advantageous was more at the points of cost-saving in gene expression and the essentiality in protein folding. © 2015 The Authors. Genes to Cells published by Molecular Biology Society of Japan and Wiley Publishing Asia Pty Ltd.

22 CFR 226.14 - Special award conditions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Special award conditions. 226.14 Section 226.14 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ADMINISTRATION OF ASSISTANCE AWARDS TO U.S. NON-GOVERNMENTAL ORGANIZATIONS Pre-award Requirements § 226.14 Special award conditions. If an applicant or...

23 CFR 1200.11 - Special funding conditions.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 23 Highways 1 2012-04-01 2012-04-01 false Special funding conditions. 1200.11 Section 1200.11... Application, Approval, and Funding of the Highway Safety Program § 1200.11 Special funding conditions. The... passengers in motor vehicles. (e) Planning and Administration Costs—Funding and matching requirements for...

Care coordination for children with special health care needs: a cohort study.

PubMed

Zanello, Elisa; Calugi, Simona; Sanders, Lee M; Lenzi, Jacopo; Faldella, Giacomo; Rucci, Paola; Fantini, Maria Pia

2017-02-03

Care coordination is widely recognized as a key element of care for patients with chronic and complex medical conditions and their families. In care for children with special health care needs the Family Pediatrician (FP) plays a central role as care coordinator. This study aims to evaluate the FPs' activities of care coordination for children with special health care needs in the pediatric primary care setting, using an on-line measurement tool. Within the prospective cohort study SpeNK (Special Needs Kids), newborns and children with special health care needs were recruited at discharge from three hospital facilities in Bologna province, from October 1st 2012 to September 30th 2014. Their FPs were invited to complete a questionnaire (SpeNK-FP) at each encounter for the patient during a 9-month period after hospital discharge. SpeNK-FP was developed by adapting the Care Coordination Measurement Tool (CCMT©) developed by Antonelli et al., to the Italian organizational context. The outcome of interest, derived from the questionnaire, is inappropriate use of services. Forty FPs completed assessments for 49 children at each of 382 clinical encounters. The majority of children (71.4%) had special health care needs, without complicating social issues. FPs reported "no need for care coordination" in 50.8% of the encounters and 41.1% of records about patient needs requiring care coordination. The most common activity implemented to meet children's needs was telephone contact with a medical provider. According to FPs, 80% of encounters prevented inappropriate services use. In multivariate regression, pediatric-specialist contact (telephone or in person) was associated with reduced odds of physician report of preventable hospitalization (OR = 0.06, 95% CI 0.01-0.42, p = 0.005). The study shows the potential for FPs in Italy to serve as care coordinators and facilitate the implementation of integrated care pathways for children with special health care needs.

THE PLUTO CODE FOR ADAPTIVE MESH COMPUTATIONS IN ASTROPHYSICAL FLUID DYNAMICS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mignone, A.; Tzeferacos, P.; Zanni, C.

We present a description of the adaptive mesh refinement (AMR) implementation of the PLUTO code for solving the equations of classical and special relativistic magnetohydrodynamics (MHD and RMHD). The current release exploits, in addition to the static grid version of the code, the distributed infrastructure of the CHOMBO library for multidimensional parallel computations over block-structured, adaptively refined grids. We employ a conservative finite-volume approach where primary flow quantities are discretized at the cell center in a dimensionally unsplit fashion using the Corner Transport Upwind method. Time stepping relies on a characteristic tracing step where piecewise parabolic method, weighted essentially non-oscillatory,more » or slope-limited linear interpolation schemes can be handily adopted. A characteristic decomposition-free version of the scheme is also illustrated. The solenoidal condition of the magnetic field is enforced by augmenting the equations with a generalized Lagrange multiplier providing propagation and damping of divergence errors through a mixed hyperbolic/parabolic explicit cleaning step. Among the novel features, we describe an extension of the scheme to include non-ideal dissipative processes, such as viscosity, resistivity, and anisotropic thermal conduction without operator splitting. Finally, we illustrate an efficient treatment of point-local, potentially stiff source terms over hierarchical nested grids by taking advantage of the adaptivity in time. Several multidimensional benchmarks and applications to problems of astrophysical relevance assess the potentiality of the AMR version of PLUTO in resolving flow features separated by large spatial and temporal disparities.« less

Health impacts of climate change and health and social inequalities in the UK.

PubMed

Paavola, Jouni

2017-12-05

This article examines how social and health inequalities shape the health impacts of climate change in the UK, and what the implications are for climate change adaptation and health care provision. The evidence generated by the other articles of the special issue were interpreted using social justice reasoning in light of additional literature, to draw out the key implications of health and social inequalities for health outcomes of climate change. Exposure to heat and cold, air pollution, pollen, food safety risks, disruptions to access to and functioning of health services and facilities, emerging infections and flooding are examined as the key impacts of climate change influencing health outcomes. Age, pre-existing medical conditions and social deprivation are found to be the key (but not only) factors that make people vulnerable and to experience more adverse health outcomes related to climate change impacts. In the future, climate change, aging population and decreasing public spending on health and social care may aggravate inequality of health outcomes related to climate change. Health education and public preparedness measures that take into account differential exposure, sensitivity and adaptive capacity of different groups help address health and social inequalities to do with climate change. Adaptation strategies based on individual preparedness, action and behaviour change may aggravate health and social inequalities due to their selective uptake, unless they are coupled with broad public information campaigns and financial support for undertaking adaptive measures.

Basic emotions and adaptation. A computational and evolutionary model.

PubMed

Pacella, Daniela; Ponticorvo, Michela; Gigliotta, Onofrio; Miglino, Orazio

2017-01-01

The core principles of the evolutionary theories of emotions declare that affective states represent crucial drives for action selection in the environment and regulated the behavior and adaptation of natural agents in ancestrally recurrent situations. While many different studies used autonomous artificial agents to simulate emotional responses and the way these patterns can affect decision-making, few are the approaches that tried to analyze the evolutionary emergence of affective behaviors directly from the specific adaptive problems posed by the ancestral environment. A model of the evolution of affective behaviors is presented using simulated artificial agents equipped with neural networks and physically inspired on the architecture of the iCub humanoid robot. We use genetic algorithms to train populations of virtual robots across generations, and investigate the spontaneous emergence of basic emotional behaviors in different experimental conditions. In particular, we focus on studying the emotion of fear, therefore the environment explored by the artificial agents can contain stimuli that are safe or dangerous to pick. The simulated task is based on classical conditioning and the agents are asked to learn a strategy to recognize whether the environment is safe or represents a threat to their lives and select the correct action to perform in absence of any visual cues. The simulated agents have special input units in their neural structure whose activation keep track of their actual "sensations" based on the outcome of past behavior. We train five different neural network architectures and then test the best ranked individuals comparing their performances and analyzing the unit activations in each individual's life cycle. We show that the agents, regardless of the presence of recurrent connections, spontaneously evolved the ability to cope with potentially dangerous environment by collecting information about the environment and then switching their behavior to a genetically selected pattern in order to maximize the possible reward. We also prove the determinant presence of an internal time perception unit for the robots to achieve the highest performance and survivability across all conditions.

Seasonal monitoring of blue mussel (Mytilus spp.) populations in a harbor area: A focus on responses to environmental factors and chronic contamination.

PubMed

Lacroix, C; Duvieilbourg, E; Guillou, N; Guyomarch, J; Bassoulet, C; Moraga, D; Chapalain, G; Auffret, M

2017-08-01

Coastal waters corresponding to macrotidal systems are among the most variable marine biotopes. Sessile animals as bivalve mollusks may however be found forming intertidal beds at high densities, as allowed by full adaptation to local conditions. A better knowledge of adaptive responses to environmental factors is required to foresee possible adverse effects of global change. At the sub-cellular level, transcriptional responses are among the earliest signals of environmental disturbances and they can reveal subtle and meaningful changes in organism exposed to stress. Three blue mussel (Mytilus spp.) populations inhabiting the Bay of Brest (France) in sites exposed to different levels of chronic pollution, from low to moderate, were surveyed upon a seasonal schedule, with special attention to the reproductive cycle. Major seawater parameters were monitored over a full-year in the framework of the S!RANO project, based on an automatic high frequency acquisition system installed aboard a ship of opportunity. The health status of mussels has been assessed by measuring a condition index and gametogenesis has been followed by histology. Selected biological responses to environmental stress were detected using a multimarker approach including expression of genes involved in chemical stress response and energetic metabolism, and cellular immune parameters. Environmental parameters showed deep seasonal variations which differed among sites. Most biological responses followed a seasonal pattern. Late winter and spring corresponded to an active reproduction period in the Bay of Brest. Earlier spawning was observed in harbor areas compared to the oceanic site and an altered physiological state was assumed in commercial harbor mussels during the reproductive period, suggesting that their health is compromised at this time of year. However, no signs of severe chemical stress were detected in both harbor mussel populations, which could reflect adaptive responses to adverse environmental conditions. Copyright © 2017 Elsevier Ltd. All rights reserved.

76 FR 8314 - Special Conditions: Gulfstream Model GVI Airplane; Operation Without Normal Electric Power

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-14

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 25 [Docket No. NM444 Special Conditions No. 25-11-03-SC] Special Conditions: Gulfstream Model GVI Airplane; Operation Without... Aviation Administration, Transport Airplane Directorate, Attn: Rules Docket (ANM-113), Docket No. NM444...

15 CFR 14.14 - High risk special award conditions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false High risk special award conditions. 14.14 Section 14.14 Commerce and Foreign Trade Office of the Secretary of Commerce UNIFORM...-PROFIT, AND COMMERCIAL ORGANIZATIONS Pre-Award Requirements § 14.14 High risk special award conditions...

77 FR 32006 - Special Conditions: Gulfstream Model GVI Airplane; High Incidence Protection

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-31

... Special Conditions No. 25-423-SC] Special Conditions: Gulfstream Model GVI Airplane; High Incidence... pertaining to a high incidence protection system that replaces the stall warning system during normal... V SR and not greater than 1.3 V SR . (6) The high incidence protection function disabled, or...

Bacterial Communities Associated with Host-Adapted Populations of Pea Aphids Revealed by Deep Sequencing of 16S Ribosomal DNA

PubMed Central

Gauthier, Jean-Pierre; Outreman, Yannick; Mieuzet, Lucie; Simon, Jean-Christophe

2015-01-01

Associations between microbes and animals are ubiquitous and hosts may benefit from harbouring microbial communities through improved resource exploitation or resistance to environmental stress. The pea aphid, Acyrthosiphon pisum, is the host of heritable bacterial symbionts, including the obligate endosymbiont Buchnera aphidicola and several facultative symbionts. While obligate symbionts supply aphids with key nutrients, facultative symbionts influence their hosts in many ways such as protection against natural enemies, heat tolerance, color change and reproduction alteration. The pea aphid also encompasses multiple plant-specialized biotypes, each adapted to one or a few legume species. Facultative symbiont communities differ strongly between biotypes, although bacterial involvement in plant specialization is uncertain. Here, we analyse the diversity of bacterial communities associated with nine biotypes of the pea aphid complex using amplicon pyrosequencing of 16S rRNA genes. Combined clustering and phylogenetic analyses of 16S sequences allowed identifying 21 bacterial OTUs (Operational Taxonomic Unit). More than 98% of the sequencing reads were assigned to known pea aphid symbionts. The presence of Wolbachia was confirmed in A. pisum while Erwinia and Pantoea, two gut associates, were detected in multiple samples. The diversity of bacterial communities harboured by pea aphid biotypes was very low, ranging from 3 to 11 OTUs across samples. Bacterial communities differed more between than within biotypes but this difference did not correlate with the genetic divergence between biotypes. Altogether, these results confirm that the aphid microbiota is dominated by a few heritable symbionts and that plant specialization is an important structuring factor of bacterial communities associated with the pea aphid complex. However, since we examined the microbiota of aphid samples kept a few generations in controlled conditions, it may be that bacterial diversity was underestimated due to the possible loss of environmental or transient taxa. PMID:25807173

Predation upon Hatchling Dinosaurs by a New Snake from the Late Cretaceous of India

PubMed Central

Wilson, Jeffrey A.; Mohabey, Dhananjay M.; Peters, Shanan E.; Head, Jason J.

2010-01-01

Derived large-mouthed snakes (macrostomatans) possess numerous specializations in their skull and lower jaws that allow them to consume large vertebrate prey. In contrast, basal snakes lack these adaptations and feed primarily on small prey items. The sequence of osteological and behavioral modifications involved in the evolution of the macrostomatan condition has remained an open question because of disagreement about the origin and interrelationships of snakes, the paucity of well-preserved early snake fossils on many continental landmasses, and the lack of information about the feeding ecology of early snakes. We report on a partial skeleton of a new 3.5-m-long snake, Sanajeh indicus gen. et sp. nov., recovered from Upper Cretaceous rocks of western India. S. indicus was fossilized in association with a sauropod dinosaur egg clutch, coiled around an egg and adjacent to the remains of a ca. 0.5-m-long hatchling. Multiple snake-egg associations at the site strongly suggest that S. indicus frequented nesting grounds and preyed on hatchling sauropods. We interpret this pattern as “ethofossil” preservation of feeding behavior. S. indicus lacks specializations of modern egg-eaters and of macrostomatans, and skull and vertebral synapomorphies place it in an intermediate position in snake phylogeny. Sanajeh and its large-bodied madtsoiid sister taxa Yurlunggur camfieldensis and Wonambi naracoortensis from the Neogene of Australia show specializations for intraoral prey transport but lack the adaptations for wide gape that characterize living macrostomatan snakes. The Dholi Dungri fossils are the second definitive association between sauropod eggs and embryonic or hatchling remains. New fossils from western India provide direct evidence of feeding ecology in a Mesozoic snake and demonstrate predation risks for hatchling sauropod dinosaurs. Our results suggest that large body size and jaw mobility afforded some non-macrostomatan snakes a greater diversity of prey items than previously suspected on the basis of extant basal snakes. PMID:20209142

Low gravity environment on-board Columbia during STS-40

NASA Technical Reports Server (NTRS)

Rogers, M. J. B.; Baugher, C. R.; Blanchard, R. C.; Delombard, R.; During, W. W.; Matthiesen, D. H.; Neupert, W.; Roussel, P.

1993-01-01

The first NASA Spacelab Life Sciences mission (SLS-I) flew 5 June to 14 June 1991 on the orbiter Columbia (STS-40). The purpose of the mission was to investigate the human body's adaptation to the low gravity conditions of space flight and the body's readjustment after the mission to the 1 g environment of earth. In addition to the life sciences experiments manifested for the Spacelab module, a variety of experiments in other scientific disciplines flew in the Spacelab and in Get Away Special (GAS) Canisters on the GAS Bridge Assembly. Several principal investigators designed and flew specialized accelerometer systems to characterize the low gravity environment. This was done to better assess the results of theft experiments. This was also the first flight of the NASA Microgravity Science and Applications Division (MSAD) sponsored Space Acceleration Measurement System (SAMS) and the first flight of the NASA Orbiter Experiments Office (OEX) sponsored Orbital Acceleration Research Experiment accelerometer (OARE). We present a brief introduction to seven STS-40 accelerometer systems and discuss and compare the resulting data.

Evaluating and Valuing Drugs for Rare Conditions: No Easy Answers.

PubMed

Ollendorf, Daniel A; Chapman, Richard H; Pearson, Steven D

2018-05-01

We find ourselves in an era of unprecedented growth in the development and use of so-called "orphan" drugs to treat rare diseases, which are poised to represent more than one-fifth of pharmaceutical expenditures by 2022. This widespread use has been facilitated by legislative and regulatory incentives in both the United States and abroad, yet US payers and health systems have not yet made a concerted effort to understand whether and how rare diseases require special considerations on their part and how to adapt traditional methods of health technology assessment and economic evaluation to accommodate these situations. In this article, we explore the general ethical dilemmas that rare diseases present, steps taken by health technology assessment bodies worldwide to define the level of rarity that would necessitate special measures and the modifications to their assessment and valuation processes needed, and the contextual components for rare-disease evaluation that lie outside of the assessment framework as a guide to US decision makers on constructing a formal and relevant process stateside. Copyright © 2018 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

The oxygen minimum zone of the eastern South Pacific

NASA Astrophysics Data System (ADS)

Ulloa, Osvaldo; Pantoja, Silvio

2009-07-01

In spite of the fact that oxygen-deficient waters with ⩽20 μM of dissolved oxygen—known as oxygen minimum zones (OMZs)—occupy only ˜1% of the volume of the global ocean, they disproportionately affect global biogeochemical cycles, particularly the nitrogen cycle. The macrobiota diversity in OMZs is low, but the fauna that do inhabit these regions present special adaptations to the low-oxygen conditions. Conversely, microbial communities in the OMZ water column and sediments are abundant and phylogenetically and metabolically very diverse, and microbial processes occurring therein (e.g., denitrification, anammox, and organic matter degradation) are important for global marine biogeochemical cycles. In this introductory article, we present the collection of papers for the special volume on the OMZ of the eastern South Pacific, one of the three main open-ocean oxygen-deficient regions of the global ocean. These papers deal with aspects of regional oceanography, inorganic and organic geochemistry, ecology, and the biochemistry of micro and macro organisms—both in the plankton and in the sediments—and past changes in the fish scales preserved in the sediments bathed by OMZ waters.

A RECENT HOST RANGE EXPANSION IN JUNONIA COENIA HÜBNER (NYMPHALIDAE): OVIPOSITION PREFERENCE, SURVIVAL, GROWTH, AND CHEMICAL DEFENSE.

PubMed

Camara, Mark D

1997-06-01

This paper reports on an investigation of two populations of Junonia coenia, the buckeye butterfly, one that feeds on the species' typical host plant (Plantago lanceolata) and one that utilizes a novel host plant (Kickxia elatine). I examined these populations for local adaptive responses in terms of oviposition behavior, growth, and chemical defense, on both P. lanceolata and K. elatine. In addition, I examined the genetic architecture underlying these traits using a full-sib quantitative genetic analysis. I found that a significant majority of females prefer the host plant species found at their collection sites in oviposition tests, but that there is no evidence that they are locally adapted in growth performance, as measured by fifth-instar and pupal weights and development times. Neither are there correlations between oviposition preferences of females and the growth performance or levels of chemical defense of their offspring. The two populations studied do, however, show specialization in terms of the levels of chemical defense they sequester from their host plants. I argue that these results indicate that natural enemies are the normal barriers to host range expansion in this oligophagous herbivore because a breakdown in those barriers results in genetic changes that enhance resistance to predation. This is despite the fact that adaptive responses in physiology are unlikely to be limited by a lack of genetic variability; the genetic architecture among traits would be conducive to specialization in growth performance; and there are costs to chemical defense in this species. All these conditions would tend to argue that J. coenia harbors considerable potential for coevolutionary interactions with its chemically defended hosts, but this potential is not realized, probably because natural selection on diet breadth by natural enemies is much stronger than selection from host plants in this system. © 1997 The Society for the Study of Evolution.

Quality of care provided in a special needs plan using a nurse care manager model.

PubMed

Wenger, Neil S; Roth, Carol P; Martin, David; Nickels, Lorraine; Beckman, Robin; Kamberg, Caren; Mach, John; Ganz, David A

2011-10-01

To comprehensively evaluate the quality of care provided in special needs plans (SNPs; Medicare Advantage plans that aim to provide specialized care for complex older adults) and specifically the nurse care management model in the community setting. We adapted 107 process-of-care quality measures across 12 conditions from the Assessing Care of Vulnerable Elders set to obtain a clinically detailed evaluation of the quality of care received by complex older enrollees in a dual eligible Evercare SNP. We abstracted 13 months of primary care medical records to delineate quality of care provided by physicians and whether there was value added from the nurse care manager model. Dual eligible Evercare SNP located in central Florida. Two-hundred thirty-one vulnerable older enrollees in the SNP who had complex disease. Based on physician medical records alone, the 231 high-risk participants (mean age 77, 67% women) received recommended care for 53% of 5,569 evaluated clinical circumstances, ranging from 12% for end-of-life care to 78% for diabetes mellitus. In fewer than 40% of these clinical circumstances was recommended care provided for dementia, falls, and urinary incontinence. In a second analysis accounting for care provided by both the Evercare nurse and the physician, recommended care was provided to patients in 69% of the 5,684 evaluated clinical circumstances. Comprehensive quality measurement applied to vulnerable older adults enrolled in one mature SNP showed that the Evercare nurse model addresses important deficits in physician care for geriatric conditions. Such measurement should be applied to other SNP models and to compare SNP care with that for complex, older, fee-for-service Medicare cohorts. © 2011, Copyright the Authors Journal compilation © 2011, The American Geriatrics Society.

Are Young Adults with Special Needs Ready for the Physical Work Demands?

ERIC Educational Resources Information Center

Ratzon, N.; Schejter, T.; Alon, E.; Schreuer, N.

2011-01-01

Youth and Adolescents with Special Needs (YASN) face many challenges during transition into employment. Although most of their physical challenges are secondary, yet they call for attention since most of them are hired for blue collar jobs. Functional Capacity Evaluation (FCE) should be adapted to prepare them addressing the physical job-demands,…

Adapting the Physical Education Program for the Student with Special Needs: A Supplement to the K-12 Physical Education Curriculum Guide.

ERIC Educational Resources Information Center

Manitoba Dept. of Education, Winnipeg.

The booklet is designed to acquaint the physical education specialist, classroom teacher, special educator, and administrator with the importance of physical education for handicapped students. An initial chapter addresses movement's effects on cognitive, affective, and psychomotor development. A second section outlines definitions of the major…

Perspectives on the Integration of Regular and Special Education: Eliminating the Knowledge Dichotomy at the University Level.

ERIC Educational Resources Information Center

Aldinger, Loviah E., Ed.

Five papers describe ways to integrate knowledge from regular and special education at the university level. L. Hudson and M. Carroll ("The Preservice Teacher Experiences Variation in the Meaning Making of Handicapped and Nonhandicapped Learners") review adaptations in a competency based teacher education program to include information on high…

International Perspectives on Problem-Based Learning: Contexts, Cultures, Challenges, and Adaptations

ERIC Educational Resources Information Center

Hmelo-Silver, Cindy E.

2012-01-01

The theme of this special issue is timely as the world becomes increasingly flat and globally connected (Friedman, 2007). By focusing on an international perspective in problem-based learning (PBL), it puts culture squarely in the center, whether it is a national or disciplinary culture. The articles in this special issue represent Thailand, South…

Special Considerations for Using Functional Behavior Assessment and Functionally-Indicated Interventions with Students in Alternative Educational Settings

ERIC Educational Resources Information Center

Ennis, Robin Parks; Jolivette, Kristine; Swoszowski, Nicole Cain

2017-01-01

Functional behavior assessment (FBA) is the process of collecting data to determine the function of an individual's behavior to develop a functionally-indicated behavioral intervention (BIP). Special adaptations may be needed to conduct FBA and implement BIPs in alternative educational settings. In this article, we highlight suggestions for…

Test Rules Differ between Groups for Special Ed.

ERIC Educational Resources Information Center

Samuels, Christina A.

2013-01-01

Champions of students with disabilities have long complained that those students are often an afterthought in state testing plans. Only after a test design is completed are educators asked to go back and adapt the questions for a student who is blind, who needs help accessing text or calculating numbers, or who must use a specialized device to…

[Definition of surgical degree of freedom by functional anatomy in liver resection surgery].

PubMed

Kraus, T W; Golling, M; Klar, E

2001-07-01

Liver resections have developed to very complex and differentiated operations, clearly adapted to individual anatomical and physiological conditions. In parallel, perioperative morbidity has been dramatically reduced. Intraoperative strict consideration of various details of hepatic anatomy, particularly of functional liver anatomy, has proved to be of particular importance when liver surgery reaches indication and technical limits. The term "functional anatomy" stands for a form of hepatic substructurization, which is primarily based on the existence of hemodynamically independent regions of liver parenchyma. A selection of some of the most important details and facts of functional liver anatomy and secondary derived guidelines for surgical strategy and technique is presented in an overview, with special focus on liver resection.

Elucidating the fungal stress response by proteomics.

PubMed

Kroll, Kristin; Pähtz, Vera; Kniemeyer, Olaf

2014-01-31

Fungal species need to cope with stress, both in the natural environment and during interaction of human- or plant pathogenic fungi with their host. Many regulatory circuits governing the fungal stress response have already been discovered. However, there are still large gaps in the knowledge concerning the changes of the proteome during adaptation to environmental stress conditions. With the application of proteomic methods, particularly 2D-gel and gel-free, LC/MS-based methods, first insights into the composition and dynamic changes of the fungal stress proteome could be obtained. Here, we review the recent proteome data generated for filamentous fungi and yeasts. This article is part of a Special Issue entitled: Trends in Microbial Proteomics. Copyright © 2013 Elsevier B.V. All rights reserved.

Postgraduate part-time education in optical design for technical personnel in the Russian optical industry

NASA Astrophysics Data System (ADS)

Khoroshev, Michael V.

1997-12-01

Traditionally two intercompletely training forms are used in Russian optical industry: a training at University and at the high technology optical plant laboratories. The curriculum adaptation for specific part-time conditions is made by associating of similar courses, intensivizing of the methodic preparation, using of the highest qualification faculty's lectors. Special attention is given to a master's skill development by the intensification of the practice part of each course of studies. Since 1961 about 2,300 diploma engineers in optical design graduated MIIGAiK Part-time Faculty. Among them are chiefs of the large scientific groups, the authors of the newest electro-optical devices, the lecturers and professors at the professional educating system.

Neuropsychology in India.

PubMed

Kumar, J Keshav; Sadasivan, Akila

2016-11-01

This is an invited paper for a special issue with the objective to provide information on neuropsychology in India. Information was gathered from a literature search and personal communication with professionals working in the field of neuropsychology. Neuropsychology as a specialization started in India approximately 40 years ago. The early years witnessed the use of Western tools for assessing patients with organic brain damage. Subsequent years saw the development of indigenous tools for use with the vast majority of the Indian population and also a few Western tests adapted to suit the needs of the unique Indian clientele. The starting of the Neuropsychology unit at the National Institute of Mental Health and Neurosciences (NIMHANS) in Bangalore in 1975 resulted in changing of the course of training and practice of Neuropsychology. The field of assessments has witnessed indigenous tests being developed, while rehabilitation programs have brought about a decline in cognitive deficits in several clinical conditions. Currently, work within the field of neuropsychology has focused on child, geriatric, acquired brain injury, and forensic populations with a development of unique rehabilitations to suit needs of several clinical conditions. However, there are very few neuropsychologists in the country, and only one nodal training center, which limits the availability of training to the large population of the country. Despite the shortcomings, the field of neuropsychology has received much attention in the recent years with the number of referrals and professionals increasing.

Diode pumped solid state kilohertz disk laser system for time-resolved combustion diagnostics under microgravity at the drop tower Bremen

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wagner, Volker; Paa, Wolfgang; Triebel, Wolfgang

We describe a specially designed diode pumped solid state laser system based on the disk laser architecture for combustion diagnostics under microgravity (μg) conditions at the drop tower in Bremen. The two-stage oscillator-amplifier-system provides an excellent beam profile (TEM{sub 00}) at narrowband operation (Δλ < 1 pm) and is tunable from 1018 nm to 1052 nm. The laser repetition rate of up to 4 kHz at pulse durations of 10 ns enables the tracking of processes on a millisecond time scale. Depending on the specific issue it is possible to convert the output radiation up to the fourth harmonic aroundmore » 257 nm. The very compact laser system is integrated in a slightly modified drop capsule and withstands decelerations of up to 50 g (>11 ms). At first the concept of the two-stage disk laser is briefly explained, followed by a detailed description of the disk laser adaption to the drop tower requirements with special focus on the intended use under μg conditions. In order to demonstrate the capabilities of the capsule laser as a tool for μg combustion diagnostics, we finally present an investigation of the precursor-reactions before the droplet ignition using 2D imaging of the Laser Induced Fluorescence of formaldehyde.« less

Bidirectional associations in multiplication memory: conditions of negative and positive transfer.

PubMed

Campbell, Jamie I D; Robert, Nicole D

2008-05-01

A variety of experimental evidence indicates that the memory representation for multiplication facts (e.g., 6 x 9 = 54) incorporates bidirectional links with a forward association from factors to product and a reverse association from product to factors. Surprisingly, the authors did not find evidence in Experiment 1 of facilitative transfer-of-practice from multiplication (6 x 9 = ?) to factoring (54 = ? x ?); in fact, multiplication practice produced item-specific interference with factoring. Similarly, the authors found no evidence in Experiment 2 that repetition of specific factoring problems (54 = ? x ?) facilitated performance of corresponding multiplication problems (6 x 9 = ?). In Experiment 3, participants practiced both multiplication and factoring and presented facilitative transfer in both directions. Thus, bidirectional facilitation occurred if both operations were practiced, but interference occurred when only one operation was practiced. We propose that this seemingly paradoxical behavior occurs because it is adaptive for the bidirectional retrieval structure to retain operational flexibility in the context of practicing both operations, whereas it is adaptive to specialize the memory representation for the practiced operation (i.e., factoring or multiplication) when only one operation is practiced.

Insect photoreceptor adaptations to night vision.

PubMed

Honkanen, Anna; Immonen, Esa-Ville; Salmela, Iikka; Heimonen, Kyösti; Weckström, Matti

2017-04-05

Night vision is ultimately about extracting information from a noisy visual input. Several species of nocturnal insects exhibit complex visually guided behaviour in conditions where most animals are practically blind. The compound eyes of nocturnal insects produce strong responses to single photons and process them into meaningful neural signals, which are amplified by specialized neuroanatomical structures. While a lot is known about the light responses and the anatomical structures that promote pooling of responses to increase sensitivity, there is still a dearth of knowledge on the physiology of night vision. Retinal photoreceptors form the first bottleneck for the transfer of visual information. In this review, we cover the basics of what is known about physiological adaptations of insect photoreceptors for low-light vision. We will also discuss major enigmas of some of the functional properties of nocturnal photoreceptors, and describe recent advances in methodologies that may help to solve them and broaden the field of insect vision research to new model animals.This article is part of the themed issue 'Vision in dim light'. © 2017 The Author(s).

An MRM-based workflow for quantifying cardiac mitochondrial protein phosphorylation in murine and human tissue.

PubMed

Lam, Maggie P Y; Scruggs, Sarah B; Kim, Tae-Young; Zong, Chenggong; Lau, Edward; Wang, Ding; Ryan, Christopher M; Faull, Kym F; Ping, Peipei

2012-08-03

The regulation of mitochondrial function is essential for cardiomyocyte adaptation to cellular stress. While it has long been understood that phosphorylation regulates flux through metabolic pathways, novel phosphorylation sites are continually being discovered in all functionally distinct areas of the mitochondrial proteome. Extracting biologically meaningful information from these phosphorylation sites requires an adaptable, sensitive, specific and robust method for their quantification. Here we report a multiple reaction monitoring-based mass spectrometric workflow for quantifying site-specific phosphorylation of mitochondrial proteins. Specifically, chromatographic and mass spectrometric conditions for 68 transitions derived from 23 murine and human phosphopeptides, and their corresponding unmodified peptides, were optimized. These methods enabled the quantification of endogenous phosphopeptides from the outer mitochondrial membrane protein VDAC, and the inner membrane proteins ANT and ETC complexes I, III and V. The development of this quantitative workflow is a pivotal step for advancing our knowledge and understanding of the regulatory effects of mitochondrial protein phosphorylation in cardiac physiology and pathophysiology. This article is part of a Special Issue entitled: Translational Proteomics. Copyright © 2012 Elsevier B.V. All rights reserved.

Genomic data as the “hitchhiker's guide” to cattle adaptation: tracking the milestones of past selection in the bovine genome

PubMed Central

Utsunomiya, Yuri T.; Pérez O'Brien, Ana M.; Sonstegard, Tad S.; Sölkner, Johann; Garcia, José F.

2015-01-01

The bovine species have witnessed and played a major role in the drastic socio-economical changes that shaped our culture over the last 10,000 years. During this journey, cattle “hitchhiked” on human development and colonized the world, facing strong selective pressures such as dramatic environmental changes and disease challenge. Consequently, hundreds of specialized cattle breeds emerged and spread around the globe, making up a rich spectrum of genomic resources. Their DNA still carry the scars left from adapting to this wide range of conditions, and we are now empowered with data and analytical tools to track the milestones of past selection in their genomes. In this review paper, we provide a summary of the reconstructed demographic events that shaped cattle diversity, offer a critical synthesis of popular methodologies applied to the search for signatures of selection (SS) in genomic data, and give examples of recent SS studies in cattle. Then, we outline the potential and challenges of the application of SS analysis in cattle, and discuss the future directions in this field. PMID:25713583

Influenza A viruses of avian origin circulating in pigs and other mammals.

PubMed

Urbaniak, Kinga; Kowalczyk, Andrzej; Markowska-Daniel, Iwona

2014-01-01

Influenza A viruses (IAVs) are zoonotic agents, capable of crossing the species barriers. Nowadays, they still constitute a great challenge worldwide. The natural reservoir of all influenza A viruses are wild aquatic birds, despite the fact they have been isolated from a number of avian and mammalian species, including humans. Even when influenza A viruses are able to get into another than waterfowl population, they are often unable to efficiently adapt and transmit between individuals. Only in rare cases, these viruses are capable of establishing a new lineage. To succeed a complete adaptation and further transmission between species, influenza A virus must overcome a species barrier, including adaptation to the receptors of a new host, which would allow the virus-cell binding, virus replication and, then, animal-to-animal transmission. For many years, pigs were thought to be intermediate host for adaptation of avian influenza viruses to humans, because of their susceptibility to infection with both, avian and human influenza viruses, which supported hypothesis of pigs as a 'mixing vessel'. In this review, the molecular factors necessary for interspecies transmission are described, with special emphasis on adaptation of avian influenza viruses to the pig population. In addition, this review gives the information about swine influenza viruses circulating around the world with special emphasis on Polish strains.

[Industrial social diseases in 19th century].

PubMed

Leoni, F

1991-01-01

The author illustrates the relations in Italy between industry and the medical-hygienic situation in the XIX century. Italy started industrial processes rather late, about 1840, and between 1840 and 1870, for the first time, a remarkable quantity of publications about working class life conditions appeared. Special attention was given to spinning-mill workers, who - as Tonini, Ripa and Bonomi describe in their treatises - suffered a very hard life and working conditions, cold, damp, a very poor diet based on stale bread; furthermore, women had dangerous pregnancies and their babies were extremely undernourished, because of bottle-feeding caused by the impossibility of mothers to take their infants with them. These conditions produced numerous gastric, rheumatic and respiratory diseases. At the end of the XIX century, Mantegazzaa defined, for the first time, professional diseases from a clinical and social point of view. Investigations acquired a more rigorous and scientific character by dividing into a series of subjects such as, for instance, the study of "unhealthy industries." Legislation was adapted quite late, and produced in 1888 the "Crispi act".

42 CFR 494.120 - Condition: Special purpose renal dialysis facilities.

Code of Federal Regulations, 2010 CFR

2010-10-01

... facilities. 494.120 Section 494.120 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF... RENAL DISEASE FACILITIES Patient Care § 494.120 Condition: Special purpose renal dialysis facilities. A special purpose renal dialysis facility is approved to furnish dialysis on a short-term basis at special...

Multistage Computerized Adaptive Testing with Uniform Item Exposure

ERIC Educational Resources Information Center

Edwards, Michael C.; Flora, David B.; Thissen, David

2012-01-01

This article describes a computerized adaptive test (CAT) based on the uniform item exposure multi-form structure (uMFS). The uMFS is a specialization of the multi-form structure (MFS) idea described by Armstrong, Jones, Berliner, and Pashley (1998). In an MFS CAT, the examinee first responds to a small fixed block of items. The items comprising…

Emergent Literacy Activities, Instructional Adaptations and School Absence of Children with Cerebral Palsy in Special Education

ERIC Educational Resources Information Center

Peeters, Marieke; de Moor, Jan; Verhoeven, Ludo

2011-01-01

The goal of the present study was to get an overview of the emergent literacy activities, instructional adaptations and school absence of children with cerebral palsy (CP) compared to normally developing peers. The results showed that there were differences between the groups regarding the amount of emergent literacy instruction. While time…

Statistical Physics of Adaptation

DTIC Science & Technology

2016-08-23

Statistical Physics of Adaptation Nikolay Perunov, Robert A. Marsland, and Jeremy L. England Department of Physics , Physics of Living Systems Group...Subject Areas: Biological Physics , Complex Systems, Statistical Physics I. INTRODUCTION It has long been understood that nonequilibrium driving can...equilibrium may appear to have been specially selected for physical properties connected to their ability to absorb work from the particular driving environment

Descriptive Survey of Grant Funded Physical Education Teachers' Knowledge, Skills, and Dispositions in Adapted Physical Education

ERIC Educational Resources Information Center

Barry, James Patrick, Jr.

2017-01-01

This study examined physical education teachers' perceptions of their knowledge, skills, and dispositions, who received federal funding and training from the Office of Special Education Programs (OSEP) in Adapted Physical Education (APE). The OSEP offers grant opportunities to institutions of higher education, non-profits, and other educational…

Contemporary and historical evolutionary processes interact to shape patterns of within-lake phenotypic divergences in polyphenic pumpkinseed sunfish, Lepomis gibbosus.

PubMed

Weese, Dylan J; Ferguson, Moira M; Robinson, Beren W

2012-03-01

Historical and contemporary evolutionary processes can both contribute to patterns of phenotypic variation among populations of a species. Recent studies are revealing how interactions between historical and contemporary processes better explain observed patterns of phenotypic divergence than either process alone. Here, we investigate the roles of evolutionary history and adaptation to current environmental conditions in structuring phenotypic variation among polyphenic populations of sunfish inhabiting 12 postglacial lakes in eastern North America. The pumpkinseed sunfish polyphenism includes sympatric ecomorphs specialized for littoral or pelagic lake habitats. First, we use population genetic methods to test the evolutionary independence of within-lake phenotypic divergences of ecomorphs and to describe patterns of genetic structure among lake populations that clustered into three geographical groupings. We then used multivariate analysis of covariance (MANCOVA) to partition body shape variation (quantified with geometric morphometrics) among the effects of evolutionary history (reflecting phenotypic variation among genetic clusters), the shared phenotypic response of all populations to alternate habitats within lakes (reflecting adaptation to contemporary conditions), and unique phenotypic responses to habitats within lakes nested within genetic clusters. All effects had a significant influence on body form, but the effects of history and the interaction between history and contemporary habitat were larger than contemporary processes in structuring phenotypic variation. This highlights how divergence can be better understood against a known backdrop of evolutionary history.

76 FR 71865 - Special Conditions: Gulfstream Aerospace Corporation, Model GVI Airplane; Windshield Coating in...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-21

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76 FR 63822 - Special Conditions: Gulfstream Aerospace LP (GALP) Model G280 Airplane, Limit Engine Torque Loads...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-14

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Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-05

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76 FR 10482 - Special Conditions: Boeing Model 787-8 Airplane; Overhead Flightcrew-Rest Compartment Occupiable...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-25

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78 FR 35747 - Special Conditions: Cirrus Design Corporation, Model SF50; Fire Extinguishing for Upper Aft...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-14

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Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-20

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75 FR 39 - Special Conditions: Boeing Model 757 Series Airplanes; Seats With Non-Traditional, Large, Non...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-04

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Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-04

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Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-23

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Enhancing the Extreme Climate Index (ECI) to monitor climate extremes for an index-based insurance scheme across Africa

NASA Astrophysics Data System (ADS)

Helmschrot, J.; Malherbe, J.; Chamunorwa, M.; Muthige, M.; Petitta, M.; Calmanti, S.; Cucchi, M.; Syroka, J.; Iyahen, E.; Engelbrecht, F.

2017-12-01

Climate services are a key component of National Adaptation Plan (NAP) processes, which require the analysis of current climate conditions, future climate change scenarios and the identification of adaptation strategies, including the capacity to finance and implement effective adaptation options. The Extreme Climate Facility (XCF) proposed by the African Risk Capacity (ARC) developed a climate index insurance scheme, which is based on the Extreme Climate Index (ECI): an objective, multi-hazard index capable of tracking changes in the frequency or magnitude of extreme weather events, thus indicating possible shifts to a new climate regime in various regions. The main hazards covered by ECI are extreme dry, wet and heat events, with the possibility of adding other region-specific risk events. The ECI is standardized across broad geographical regions, so that extreme events occurring under different climatic regimes in Africa can be compared. Initially developed by an Italian company specialized in Climate Services, research is now conducted at the CSIR and SASSCAL, to verify and further develop the ECI for application in southern African countries, through a project initiated by the World Food Programme (WFP) and ARC. The paper will present findings on the most appropriate definitions of extremely wet and dry conditions in Africa, in terms of their impact across a multitude of sub-regional climates of the African continent. Findings of a verification analysis of the ECI, as determined through vegetation monitoring data and the SASSCAL weather station network will be discussed. Changes in the ECI under climate change will subsequently be projected, using detailed regional projections generated by the CSIR and through the Coordinated Regional Downscaling Experiment (CORDEX). This work will be concluded by the development of a web-based climate service informing African Stakeholders on climate extremes.

Adaptation of retrovirus producer cells to serum deprivation: Implications in lipid biosynthesis and vector production.

PubMed

Rodrigues, A F; Amaral, A I; Veríssimo, V; Alves, P M; Coroadinha, A S

2012-05-01

The manufacture of enveloped virus, particularly retroviral (RV) and lentiviral (LV) vectors, faces the challenge of low titers that are aggravated under serum deprivation culture conditions. Also, the scarce knowledge on the biochemical pathways related with virus production is still limiting the design of rational strategies for improved production yields. This work describes the adaptation to serum deprivation of two human RV packaging cell lines, 293 FLEX and Te Fly and its effects on lipid biosynthetic pathways and infectious vector production. Total lipid content as well as cellular cholesterol were quantified and lipid biosynthesis was assessed by (13)C-NMR spectroscopy; changes in gene expression of lipid biosynthetic enzymes were also evaluated. The effects of adaptation to serum deprivation in lipid biosynthesis were cell line specific and directly correlated with infectious virus titers: 293 FLEX cells faced severe lipid starvation-up to 50% reduction in total lipid content-along with a 68-fold reduction in infectious vector titers; contrarily, Te Fly cells were able to maintain identical levels of total lipid content by rising de novo lipid biosynthesis, particularly for cholesterol-50-fold increase-with the consequent recovery of infectious vector productivities. Gene expression analysis of lipid biosynthetic enzymes further confirmed cholesterol production pathway to be prominently up-regulated under serum deprivation conditions for Te Fly cells, providing a genotype-phenotype validation for enhanced cholesterol synthesis. These results highlight lipid metabolism dynamics and the ability to activate lipid biosynthesis under serum deprivation as an important feature for high retroviral titers. Mechanisms underlying virus production and its relationship with lipid biosynthesis, with special focus on cholesterol, are discussed as potential targets for cellular metabolic engineering. Copyright © 2011 Wiley Periodicals, Inc.

Genome Features of “Dark-Fly”, a Drosophila Line Reared Long-Term in a Dark Environment

PubMed Central

Zhou, Jun; Sugiyama, Yuzo; Nishimura, Osamu; Aizu, Tomoyuki; Toyoda, Atsushi; Fujiyama, Asao; Agata, Kiyokazu

2012-01-01

Organisms are remarkably adapted to diverse environments by specialized metabolisms, morphology, or behaviors. To address the molecular mechanisms underlying environmental adaptation, we have utilized a Drosophila melanogaster line, termed “Dark-fly”, which has been maintained in constant dark conditions for 57 years (1400 generations). We found that Dark-fly exhibited higher fecundity in dark than in light conditions, indicating that Dark-fly possesses some traits advantageous in darkness. Using next-generation sequencing technology, we determined the whole genome sequence of Dark-fly and identified approximately 220,000 single nucleotide polymorphisms (SNPs) and 4,700 insertions or deletions (InDels) in the Dark-fly genome compared to the genome of the Oregon-R-S strain, a control strain. 1.8% of SNPs were classified as non-synonymous SNPs (nsSNPs: i.e., they alter the amino acid sequence of gene products). Among them, we detected 28 nonsense mutations (i.e., they produce a stop codon in the protein sequence) in the Dark-fly genome. These included genes encoding an olfactory receptor and a light receptor. We also searched runs of homozygosity (ROH) regions as putative regions selected during the population history, and found 21 ROH regions in the Dark-fly genome. We identified 241 genes carrying nsSNPs or InDels in the ROH regions. These include a cluster of alpha-esterase genes that are involved in detoxification processes. Furthermore, analysis of structural variants in the Dark-fly genome showed the deletion of a gene related to fatty acid metabolism. Our results revealed unique features of the Dark-fly genome and provided a list of potential candidate genes involved in environmental adaptation. PMID:22432011

Specialized computer system to diagnose critical lined equipment

NASA Astrophysics Data System (ADS)

Yemelyanov, V. A.; Yemelyanova, N. Y.; Morozova, O. A.; Nedelkin, A. A.

2018-05-01

The paper presents data on the problem of diagnosing the lining condition at the iron and steel works. The authors propose and describe the structure of the specialized computer system to diagnose critical lined equipment. The relative results of diagnosing lining condition by the basic system and the proposed specialized computer system are presented. To automate evaluation of lining condition and support in making decisions regarding the operation mode of the lined equipment, the specialized software has been developed.

Developing Organizational Adaptability for Complex Environment

ERIC Educational Resources Information Center

Boylan, Steven A.; Turner, Kenneth A.

2017-01-01

Developing organizations capable of adapting requires leaders to set conditions. Setting conditions normally requires purposeful activities by the leadership to foster and develop leader and individual adaptability, supported by processes and activities that enable adaptive behaviors through the totality of the organization (Goldstein, Hazy, &…

Effects of Crowding and Attention on High-Levels of Motion Processing and Motion Adaptation

PubMed Central

Pavan, Andrea; Greenlee, Mark W.

2015-01-01

The motion after-effect (MAE) persists in crowding conditions, i.e., when the adaptation direction cannot be reliably perceived. The MAE originating from complex moving patterns spreads into non-adapted sectors of a multi-sector adapting display (i.e., phantom MAE). In the present study we used global rotating patterns to measure the strength of the conventional and phantom MAEs in crowded and non-crowded conditions, and when attention was directed to the adapting stimulus and when it was diverted away from the adapting stimulus. The results show that: (i) the phantom MAE is weaker than the conventional MAE, for both non-crowded and crowded conditions, and when attention was focused on the adapting stimulus and when it was diverted from it, (ii) conventional and phantom MAEs in the crowded condition are weaker than in the non-crowded condition. Analysis conducted to assess the effect of crowding on high-level of motion adaptation suggests that crowding is likely to affect the awareness of the adapting stimulus rather than degrading its sensory representation, (iii) for high-level of motion processing the attentional manipulation does not affect the strength of either conventional or phantom MAEs, neither in the non-crowded nor in the crowded conditions. These results suggest that high-level MAEs do not depend on attention and that at high-level of motion adaptation the effects of crowding are not modulated by attention. PMID:25615577

Apparatus for adapting an end effector device remotely controlled manipulator arm

NASA Technical Reports Server (NTRS)

Clark, K. H. (Inventor)

1985-01-01

Apparatus for adapting a general purpose and effector device to a special purpose and effector is disclosed which includes an adapter bracket assembly which provides a mechanical and electrical interface between the end effector devices. The adapter bracket assembly includes an adapter connector post which interlocks with a diamond shaped gripping channel formed in closed jaws of the general purpose end effector. The angularly intersecting surfaces of the connector post and gripping channel prevent any relative movement there between. Containment webs constrain the outer finger plates of the general purpose jaws to prevent pitch motion. Electrical interface is provided by conical, self aligning electrical connector components carried by respective ones of said end effectors.

The reproductive strategy of a pollinator-limited Himalayan plant, Incarvillea mairei (Bignoniaceae)

PubMed Central

2013-01-01

Background Plants may adapt to alpine habitats by specialization in the reproductive strategy and functional aspects of their flowers and pollination systems. Alpine habitats reduce the opportunities for cross-pollination in a relatively high proportion of alpine plant species, and self-pollination may be favored in these adverse conditions. Here, we investigated the mating system and pollination of Incarvillea mairei, a perennial Himalayan herb typically found at altitudes between 3000 and 4500 m. Results Analyses of floral morphology, observation of plant-pollinator interactions, and hand pollination experiments were conducted in three natural populations. Outcrossing rates and effective numbers of pollen donors were assessed in 45 open-pollinated families by using progeny analysis based on seven microsatellite markers. Incarvillea mairei displayed a set of apparently specialized floral traits, the stigma is sensitive to touch and close immediately and its reopening allows a second opportunity for the receipt of pollen. The species is fully self-compatible but employs a predominantly outcrossing mating system according to parentage analysis (tm > 0.9). Fruit set was low (26.3%), whereas seed set was high (67.2%), indicating that this species suffers pollinator limitation. Its main effective pollinator was Halictus sp., and visitation frequency was low. Conclusions Floral features such as having a sensitive stigma and anther-prongs, in conjunction with pollinator behavior, function together contributing to a set of unique reproductive adaptations that enhance outcrossing success. The increased floral longevity and high pollination efficiency operated as compensatory mechanisms to counteract low pollinator visitation frequency. PMID:24289097

Acetone-butanol fermentation of lignocellulosic hydrolysates for the butanol production

NASA Astrophysics Data System (ADS)

Morozova, Tatyana; Semyonov, Sergey

2017-11-01

It is known that the use of lignocellulosic hydrolysates reduces the production cost of biofuel such as biobutanol and bioethanol. But for the most successful application of the hydrolysates for the biofuel production, it is necessary to apply an inexpensive and effective detoxification method and to use of cost-effective growth factors. In the present study, we evaluated the use of an acid hydrolysate of spruce and an enzymatic hydrolysate of miscanthus cellulose for the biobutanol production. To remove inhibitors from the hydrolysates, we applied the traditional physicochemical method with overliming and the biodetoxification method based on the use of the specially adapted activated sludge. Calcium hydroxide (150 g/L) was used for the neutralization. The biological method of detoxification of lignocellulosic hydrolysates was carried out under non-sterile conditions at room temperature by the specially adapted activated sludge of the urban wastewater treatment plants. The acetone-butanol fermentation was carried out by a strain of bacteria Clostridium acetobutylicum ATCC 824. The treatment by overliming removed 84-85 % and 83-86% of 5-hydroxymethylfurfural (5-HMF) and furfural from the hydrolysates respectively. Using the method of biodetoxification the content of furfural decreased by 98% and concentration of 5-HMF - by 97-99%. In the present study as an inexpensive source of growth substances for the fermentation of the hydrolysates it has been suggested to use decantate of the brewer's spent grain. The obtained results showed that the brewer's spent grain can be used in the biofuel production as efficiently as the synthetic growth substances.

A Middle Triassic thoracopterid from China highlights the evolutionary origin of overwater gliding in early ray-finned fishes.

PubMed

Xu, Guang-Hui; Zhao, Li-Jun; Shen, Chen-Chen

2015-01-01

Gliding adaptations in thoracopterid flying fishes represent a remarkable case of convergent evolution of overwater gliding strategy with modern exocoetid flying fishes, but the evolutionary origin of this strategy was poorly known in the thoracopterids because of lack of transitional forms. Until recently, all thoracopterids, from the Late Triassic of Austria and Italy and the Middle Triassic of South China, were highly specialized 'four-winged' gliders in having wing-like paired fins and an asymmetrical caudal fin with the lower caudal lobe notably larger than the upper lobe. Here, we show that the new genus Wushaichthys and the previously alleged 'peltopleurid' Peripeltopleurus, from the Middle Triassic (Ladinian, 235-242 Ma) of South China and near the Ladinian/Anisian boundary of southern Switzerland and northern Italy, respectively, represent the most primitive and oldest known thoracopterids. Wushaichthys, the most basal thoracopterid, shows certain derived features of this group in the skull. Peripeltopleurus shows a condition intermediate between Wushaichthys and Thoracopterus in having a slightly asymmetrical caudal fin but still lacking wing-like paired fins. Phylogenetic studies suggest that the evolution of overwater gliding of thoracopterids was gradual in nature; a four-stage adaption following the 'cranial specialization-asymmetrical caudal fin-enlarged paired fins-scale reduction' sequence has been recognized in thoracopterid evolution. Moreover, Wushaichthys and Peripeltopleurus bear hooklets on the anal fin of supposed males, resembling those of modern viviparious teleosts. Early thoracopterids probably had evolved a live-bearing reproductive strategy. © 2015 The Author(s) Published by the Royal Society. All rights reserved.

Recurrent specialization on a toxic fruit in an island Drosophila population

PubMed Central

Yassin, Amir; Debat, Vincent; Bastide, Héloïse; Gidaszewski, Nelly; David, Jean R.; Pool, John E.

2016-01-01

Recurrent specialization on similar host plants offers a unique opportunity to unravel the evolutionary and genetic mechanisms underlying dietary shifts. Recent studies have focused on ecological races belonging to the same species, but it is hard in many cases to untangle the role of adaptive introgression versus distinct mutations in facilitating recurrent evolution. We discovered on the island of Mayotte a population of the generalist fly Drosophila yakuba that is strictly associated with noni (Morinda citrifolia). This case strongly resembles Drosophila sechellia, a genetically isolated insular relative of D. yakuba whose intensely studied specialization on toxic noni fruits has always been considered a unique event in insect evolution. Experiments revealed that unlike mainland D. yakuba strains, Mayotte flies showed strong olfactory attraction and significant toxin tolerance to noni. Island females strongly discriminated against mainland males, suggesting that dietary adaptation has been accompanied by partial reproductive isolation. Population genomic analysis indicated a recent colonization (∼29 kya), at a time when year-round noni fruits may have presented a predictable resource on the small island, with ongoing migration after colonization. This relatively recent time scale allowed us to search for putatively adaptive loci based on genetic variation. Strong signals of genetic differentiation were found for several detoxification genes, including a major toxin tolerance locus in D. sechellia. Our results suggest that recurrent evolution on a toxic resource can involve similar historical events and common genetic bases, and they establish an important genetic system for the study of early stages of ecological specialization and speciation. PMID:27044093

Pre-adaptations and the evolution of pollination by sexual deception: Cope's rule of specialization revisited

PubMed Central

Vereecken, Nicolas J.; Wilson, Carol A.; Hötling, Susann; Schulz, Stefan; Banketov, Sergey A.; Mardulyn, Patrick

2012-01-01

Pollination by sexual deception is arguably one of the most unusual liaisons linking plants and insects, and perhaps the most illustrative example of extreme floral specialization in angiosperms. While considerable progress has been made in understanding the floral traits involved in sexual deception, less is known about how this remarkable mimicry system might have arisen, the role of pre-adaptations in promoting its evolution and its extent as a pollination mechanism outside the few groups of plants (primarily orchids) where it has been described to date. In the Euro-Mediterranean region, pollination by sexual deception is traditionally considered to be the hallmark of the orchid genus Ophrys. Here, we introduce two new cases outside of Ophrys, in plant groups dominated by generalized, shelter-mimicking species. On the basis of phylogenetic reconstructions of ancestral pollination strategies, we provide evidence for independent and bidirectional evolutionary transitions between generalized (shelter mimicry) and specialized (sexual deception) pollination strategies in three groups of flowering plants, and suggest that pseudocopulation has evolved from pre-adaptations (floral colours, shapes and odour bouquets) that selectively attract male pollinators through shelter mimicry. These findings, along with comparative analyses of floral traits (colours and scents), shed light on particular phenotypic changes that might have fuelled the parallel evolution of these extraordinary pollination strategies. Collectively, our results provide the first substantive insights into how pollination sexual deception might have evolved in the Euro-Mediterranean region, and demonstrate that even the most extreme cases of pollinator specialization can reverse to more generalized interactions, breaking ‘Cope's rule of specialization’. PMID:23055065

78 FR 64415 - Special Conditions: Airbus, Model A350-900 Series Airplane; Ground Pivoting Loads

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-29

... series because of a novel or unusual design feature, special conditions are prescribed under Sec. 21.16... A350-900 series airplane will incorporate the following novel or unusual design features: a braking...-0890; Notice No. 25-13-10-SC] Special Conditions: Airbus, Model A350-900 Series Airplane; Ground...

76 FR 63818 - Special Conditions: Boeing Model 767-400ER Series Airplanes; Seats With Inflatable Lapbelts

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-14

... appropriate safety standards for the 767-400ER series airplanes because of a novel or unusual design feature...-1106; Special Conditions No. 25-448-SC] Special Conditions: Boeing Model 767-400ER Series Airplanes...- 400ER series airplane. These airplanes, as modified by Continental Airlines, will have a novel or...

45 CFR 1183.12 - Special grant or subgrant conditions for “high-risk” grantees.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 3 2010-10-01 2010-10-01 false Special grant or subgrant conditions for âhigh...) NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES INSTITUTE OF MUSEUM AND LIBRARY SERVICES UNIFORM... Requirements § 1183.12 Special grant or subgrant conditions for “high-risk” grantees. (a) A grantee or...

78 FR 11998 - Paroling, Recommitting, and Supervising Federal Prisoners: Prisoners Serving Sentences Under the...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-21

... organizations. We also propose to add new procedures for imposing special conditions for sex offenders, and to... special conditions of release for some sex offenders on parole or supervised release. For an offender convicted of a sex offense, we may impose a special condition for sex offender evaluation and treatment...

76 FR 81360 - Special Conditions: Gulfstream Aerospace LP (GALP) Model G280 Airplane, Operation Without Normal...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-28

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 25 [Docket No. FAA-2011-1172: Special Conditions No. 25-453-SC] Special Conditions: Gulfstream Aerospace LP (GALP) Model G280... is not equipped with a Ram Air Turbine (RAT) generator. The loss of all electrical power to certain...

77 FR 2015 - Special Conditions: Pratt and Whitney Canada Model PW210S Turboshaft Engine

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-13

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 33 [Docket No. NE130; Special Conditions No. 33-008-SC] Special Conditions: Pratt and Whitney Canada Model PW210S Turboshaft Engine Correction In rule document 2011-14113 appearing on pages 33981-33982 in the issue of Friday, June...

75 FR 2434 - Special Conditions: Boeing Model 747-8/-8F Series Airplanes; Design Roll Maneuver Requirement

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-15

... have novel or unusual design features when compared to the state of technology envisioned in the... standards. Additional special conditions will be issued for other novel or unusual design features of the... 747-8/-8F because of a novel or unusual design feature, special conditions are prescribed under the...

75 FR 32 - Special Conditions: Airbus Model A340 Series Airplanes; Seats With Non-Traditional, Large, Non...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-04

... incorporate non-traditional, large, non-metallic panels. To provide a level of safety that is equivalent to...; Special Conditions No. 25-399-SC] Special Conditions: Airbus Model A340 Series Airplanes; Seats With Non-Traditional, Large, Non-Metallic Panels AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final...

77 FR 40255 - Special Conditions: Boeing, Model 737-800; Large Non-Structural Glass in the Passenger Compartment

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-09

...-0499; Special Conditions No. 25-466-SC] Special Conditions: Boeing, Model 737-800; Large Non-Structural... with the installation of large non-structural glass items in the cabin area of an executive interior... Administrator considers necessary to establish a level of safety equivalent to that established by the existing...

75 FR 37 - Special Conditions: Airbus Model A330 Series Airplanes; Seats with Non-Traditional, Large, Non...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-04

...-traditional, large, non-metallic panels. To provide a level of safety that is equivalent to that provided by...; Special Conditions No. 25-400-SC] Special Conditions: Airbus Model A330 Series Airplanes; Seats with Non-Traditional, Large, Non-Metallic Panels AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final...

Activity-Dependent Changes in the Firing Properties of Neocortical Fast-Spiking Interneurons in the Absence of Large Changes in Gene Expression

PubMed Central

Miller, Mark N.; Okaty, Benjamin W.; Kato, Saori; Nelson, Sacha B.

2010-01-01

The diverse cell types that comprise neocortical circuits each have characteristic integrative and firing properties that are specialized to perform specific functions within the network. Parvalbumin-positive fast-spiking (FS) interneurons are a particularly specialized cortical cell-type that controls the dynamics of ongoing activity and prevents runaway excitation by virtue of remarkably high firing rates, a feature that is permitted by narrow action potentials and the absence of spike-frequency adaptation. Although several neuronal intrinsic membrane properties undergo activity-dependent plasticity, the role of network activity in shaping and maintaining specialized, cell-type-specific firing properties is unknown. We tested whether the specialized firing properties of mature FS interneurons are sensitive to activity perturbations by inactivating a portion of motor cortex in vivo for 48 hours and measuring resulting plasticity of FS intrinsic and firing properties with whole-cell recording in acute slices. Many of the characteristic properties of FS interneurons, including non-adapting high-frequency spiking and narrow action potentials, were profoundly affected by activity deprivation both at an age just after maturation of FS firing properties and also a week after their maturation. Using microarray screening, we determined that although normal maturation of FS electrophysiological specializations is accompanied by large-scale transcriptional changes, the effects of deprivation on the same specializations involve more modest transcriptional changes, and may instead be primarily mediated by post-transcriptional mechanisms. PMID:21154910

Interactions of C4 subtype metabolic activities and transport in maize are revealed through the characterization of DCT2 mutants

USDA-ARS?s Scientific Manuscript database

C4 photosynthesis is an elaborate set of metabolic pathways that utilize specialized anatomical and biochemical adaptations to concentrate CO2 around RuBisCO. The activities of the C4 pathways are coordinated between two specialized leaf cell types, mesophyll (M) and bundle sheath (BS), and rely hea...

Kansas Adapted/Special Physical Education Test Manual. Health Related Fitness and Psychomotor Testing.

ERIC Educational Resources Information Center

Johnson, Robert E.; Lavay, Barry

This manual was developed to address the need for health-related physical fitness testing of children with special needs. The first section defines the components of health-related physical fitness which consist of: (1)abdominal strength and endurance measured by a sit-up test; (2) flexibility, measured by a sit and reach test; (3) upper body…

Adaptation and Employment of Special Groups of Manpower. Implementing an Active Manpower Policy; Conclusions of the Manpower and Social Affairs Committee.

ERIC Educational Resources Information Center

Organisation for Economic Cooperation and Development, Paris (France).

Conclusions are presented indicating the role which public bodies, employers, trade unions, and other private groups can play in improving the employment opportunities of special groups, such as older workers, workers with family responsibilities, and workers of rural origin engaged in non-agricultural employment. Because of the increasing number…

FARM WORKERS IN A SPECIALIZED SEASONAL CROP AREA, STANISLAUS COUNTY, CALIFORNIA.

ERIC Educational Resources Information Center

METZLER, WILLIAM H.

SPECIALIZATION IN THE CROPS BEST ADAPTED TO THE LOCAL AREA IS SEEN AS A HIGHLY PRODUCTIVE SYSTEM OF AGRICULTURE, BUT BY CREATING THE NEED FOR LARGE NUMBERS OF WORKERS FOR SHORT PERIODS OF TIME, IT CAUSES UNEMPLOYMENT AND MIGRATION. A SURVEY OF FRUIT AND VEGETABLE WORKERS IN STANISLAUS COUNTY, CALIFORNIA IN 1962-63 REVEALS--(1) THEIR EARNINGS ARE…

Adapting the Music Curriculum for Senior Secondary Students with Intellectual Disabilities in Hong Kong: Content, Pedagogy and Mindsets

ERIC Educational Resources Information Center

Wong, Marina Wai-yee

2015-01-01

Why should bringing the power of music into student learning be a challenge--even more so when the class comprises students deemed in need of "special education"? To address this question, three case studies are presented of Hong Kong special schools music teachers experienced in teaching students with intellectual disabilities at senior…

Adaptable bioinspired special wetting surface for multifunctional oil/water separation

NASA Astrophysics Data System (ADS)

Kavalenka, Maryna N.; Vüllers, Felix; Kumberg, Jana; Zeiger, Claudia; Trouillet, Vanessa; Stein, Sebastian; Ava, Tanzila T.; Li, Chunyan; Worgull, Matthias; Hölscher, Hendrik

2017-01-01

Inspired by the multifunctionality of biological surfaces necessary for the survival of an organism in its specific environment, we developed an artificial special wetting nanofur surface which can be adapted to perform different functionalities necessary to efficiently separate oil and water for cleaning accidental oil spills or separating industrial oily wastewater. Initial superhydrophobic nanofur surface is fabricated using a hot pulling method, in which nano- and microhairs are drawn out of the polymer surface during separation from a heated sandblasted steel plate. By using a set of simple modification techniques, which include microperforation, plasma treatment and subsequent control of storage environment, we achieved selective separation of either water or oil, variable oil absorption and continuous gravity driven separation of oil/water mixtures by filtration. Furthermore, these functions can be performed using special wetting nanofur made from various thermoplastics, including biodegradable and recyclable polymers. Additionally, nanofur can be reused after washing it with organic solvents, thus, further helping to reduce the environmental impacts of oil/water separation processes.

Immune modulation enables a specialist insect to benefit from antibacterial withanolides in its host plant

PubMed Central

Barthel, Andrea; Vogel, Heiko; Pauchet, Yannick; Pauls, Gerhard; Kunert, Grit; Groot, Astrid T.; Boland, Wilhelm; Heckel, David G.; Heidel-Fischer, Hanna M.

2016-01-01

The development of novel plant chemical defenses and counter adaptations by herbivorous insect could continually drive speciation, producing more insect specialists than generalists. One approach to test this hypothesis is to compare closely related generalist and specialist species to reveal the associated costs and benefits of these different adaptive strategies. We use the specialized moth Heliothis subflexa, which feeds exclusively on plants in the genus Physalis, and its close generalist relative H. virescens. Specialization on Physalis plants necessitates the ability to tolerate withanolides, the secondary metabolites of Physalis species that are known to have feeding deterrent and immune inhibiting properties for other insects. Here we find that only H. subflexa benefits from the antibacterial properties of withanolides, and thereby gains a higher tolerance of the pathogen Bacillus thuringiensis. We argue that the specialization in H. subflexa has been guided to a large extent by a unique role of plant chemistry on ecological immunology. PMID:27561781

Adaptable bioinspired special wetting surface for multifunctional oil/water separation

PubMed Central

Kavalenka, Maryna N.; Vüllers, Felix; Kumberg, Jana; Zeiger, Claudia; Trouillet, Vanessa; Stein, Sebastian; Ava, Tanzila T.; Li, Chunyan; Worgull, Matthias; Hölscher, Hendrik

2017-01-01

Inspired by the multifunctionality of biological surfaces necessary for the survival of an organism in its specific environment, we developed an artificial special wetting nanofur surface which can be adapted to perform different functionalities necessary to efficiently separate oil and water for cleaning accidental oil spills or separating industrial oily wastewater. Initial superhydrophobic nanofur surface is fabricated using a hot pulling method, in which nano- and microhairs are drawn out of the polymer surface during separation from a heated sandblasted steel plate. By using a set of simple modification techniques, which include microperforation, plasma treatment and subsequent control of storage environment, we achieved selective separation of either water or oil, variable oil absorption and continuous gravity driven separation of oil/water mixtures by filtration. Furthermore, these functions can be performed using special wetting nanofur made from various thermoplastics, including biodegradable and recyclable polymers. Additionally, nanofur can be reused after washing it with organic solvents, thus, further helping to reduce the environmental impacts of oil/water separation processes. PMID:28051163

Growth condition-dependent cell surface proteome analysis of Enterococcus faecium.

PubMed

Sinnige, Jan C; de Been, Mark; Zhou, Miaomiao; Bonten, Marc J M; Willems, Rob J L; Top, Janetta

2015-11-01

The last 30 years Enterococcus faecium has become an important nosocomial pathogen in hospitals worldwide. The aim of this study was to obtain insight in the cell surface proteome of E. faecium when grown in laboratory and clinically relevant conditions. Enterococcus faecium E1162, a clinical blood stream isolate, was grown until mid-log phase in brain heart infusion medium (BHI) with, or without 0.02% bile salts, Tryptic Soy Broth with 1% glucose (TSBg) and urine, and its cell surface was "shaved" using immobilized trypsin. Peptides were identified using MS/MS. Mapping against the translated E1162 whole genome sequence identified 67 proteins that were differentially detected in different conditions. In urine, 14 proteins were significantly more and nine proteins less abundant relative to the other conditions. Growth in BHI-bile and TSBg, revealed four and six proteins, respectively, which were uniquely present in these conditions while two proteins were uniquely present in both conditions. Thus, proteolytic shaving of E. faecium cells identified differentially surface exposed proteins in different growth conditions. These proteins are of special interest as they provide more insight in the adaptive mechanisms and may serve as targets for the development of novel therapeutics against this multi-resistant emerging pathogen. All MS data have been deposited in the ProteomeXchange with identifier PXD002497 (http://proteomecentral.proteomexchange.org/dataset/PXD002497). © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

A Stromal Cell Niche for Human and Mouse Type 3 Innate Lymphoid Cells.

PubMed

Hoorweg, Kerim; Narang, Priyanka; Li, Zhi; Thuery, Anne; Papazian, Natalie; Withers, David R; Coles, Mark C; Cupedo, Tom

2015-11-01

Adaptive immunity critically depends on the functional compartmentalization of secondary lymphoid organs. Mesenchymal stromal cells create and maintain specialized niches that support survival, activation, and expansion of T and B cells, and integrated analysis of lymphocytes and their niche has been instrumental in understanding adaptive immunity. Lymphoid organs are also home to type 3 innate lymphoid cells (ILC3), innate effector cells essential for barrier immunity. However, a specialized stromal niche for ILC3 has not been identified. A novel lineage-tracing approach now identifies a subset of murine fetal lymphoid tissue organizer cells that gives rise exclusively to adult marginal reticular cells. Moreover, both cell types are conserved from mice to humans and colocalize with ILC3 in secondary lymphoid tissues throughout life. In sum, we provide evidence that fetal stromal organizers give rise to adult marginal reticular cells and form a dedicated stromal niche for innate ILC3 in adaptive lymphoid organs. Copyright © 2015 by The American Association of Immunologists, Inc.

An Examination of Current Adapted Physical Activity Provision in Primary and Special Schools in Ireland

ERIC Educational Resources Information Center

Crawford, Susan

2011-01-01

The Disability in Sport Taskforce report examining adapted physical activity (APA) in the Irish context (Department of Education and Science, 1999) found that teachers involved in primary mainstream and specialist settings expressed a grave lack of self-confidence, due to lack of training, in the delivery of APA programmes to children with special…

Implementing an Adaptive Physical Education Program for Educable Mentally Retarded Children, Kindergarten through Third Grade.

ERIC Educational Resources Information Center

Keller, Mimi

An adaptive physical education program was implemented for two special classes of educable mentally retarded children, grades K-3 in California. Children from a regular kindergarten class also participated in the program. The program operated for 5 months, with children receiving motor skills training 40 minutes per day, 4 days per week. Analysis…

Structural Equation Modeling for Studying Adaptation of the Students with Disabilities in Inclusive Junior High Schools

ERIC Educational Resources Information Center

Chen, Li Ju

2014-01-01

This research explored the factors of the adaptation for the children with disabilities studying in inclusive junior high schools. The subjects were recruited from the Special Needs Education Longitudinal Study of Taiwan. The result of the Confirmatory Factor Analyses reflects that there are two, three and five observed variables included in the…

Adaptive Driving Equipment: Selection and Major Considerations [and] Battery Powered Scooters and 3-Wheelers. Information Support Packets #1 and #2.

ERIC Educational Resources Information Center

Stevens, John H.

Two brief guides offer suggestions for persons with physical disabilities who are considering the purchase of adaptive driving equipment, battery-powered scooters, or three wheelers. The first guide offers guidelines for individuals considering purchase of special hand controls or other modifications or a van lift to enhance their independence in…

A Short Version of SIS (Support Intensity Scale): The Utility of the Application of Artificial Adaptive Systems

ERIC Educational Resources Information Center

Gomiero, Tiziano; Croce, Luigi; Grossi, Enzo; Luc, De Vreese; Buscema, Massimo; Mantesso, Ulrico; De Bastiani, Elisa

2011-01-01

The aim of this paper is to present a shortened version of the SIS (support intensity scale) obtained by the application of mathematical models and instruments, adopting special algorithms based on the most recent developments in artificial adaptive systems. All the variables of SIS applied to 1,052 subjects with ID (intellectual disabilities)…

Integrating Adaptability into Special Operations Forces Intermediate Level Education

DTIC Science & Technology

2010-10-01

This model is based on the Experiential Learning Theory (ELT), which states that learning occurs by the transfer of experience into knowledge ( Kolb ...Report 529. Arlington, VA. Kolb , D.A., Boyatzis, R.E., & Mainemelis, C. (2000). Experiential Learning Theory : Previous research and new dimensions. In...adaptive thinking materials. Integrating this information will provide some continuity among concepts for instruction. Experiential Learning Model

Adaptations of Homemaking Skills for the Aged: Nutritional Needs. Teacher's Manual and Participant's Manual.

ERIC Educational Resources Information Center

Pestle, Ruth E.; Wilcox, Catherine F.

This manual is designed for use with adults or secondary school home economics students to help them become more aware of: (1) the nutritional needs of the aged; (2) the physical and social limitations affecting aged homemakers; and (3) the adaptations in individual dietary habits that will meet nutritional needs. The special nutritional needs of…

Developing Rational-Empirical Views of Intelligent Adaptive Behavior

DTIC Science & Technology

2004-08-01

biological frame to the information processing model and outline our understanding of intentions and beliefs that co-exist with rational and...notion that the evolution of cognition has produced memory/ knowledge systems that specialize in the processing of particular types of information ...1 PERMIS 2004 Developing Rational-Empirical Views of Intelligent Adaptive Behavior Gary Berg-Cross, Knowledge Strategies Potomac, Maryland

Scientific Design of a High Contrast Integral Field Spectrograph for the Subaru Telescope

NASA Technical Reports Server (NTRS)

McElwain, Michael W.

2012-01-01

Ground based telescopes equipped with adaptive optics systems and specialized science cameras are now capable of directly detecting extrasolar planets. We present the scientific design for a high contrast integral field spectrograph for the Subaru Telescope. This lenslet based integral field spectrograph will be implemented into the new extreme adaptive optics system at Subaru, called SCExAO.

Psychosocial Adaptation to Visual Impairment and Its Relationship to Depressive Affect in Older Adults with Age-Related Macular Degeneration

ERIC Educational Resources Information Center

Tolman, Jennifer; Hill, Robert D.; Kleinschmidt, Julia J.; Gregg, Charles H.

2005-01-01

Purpose: In this study we examined psychosocial adaptation to vision loss and its relationship to depressive symptomatology in legally blind older adults with age-related macular degeneration (ARMD). Design and Methods: The 144 study participants were outpatients of a large regional vision clinic that specializes in the diagnosis and treatment of…

Physiological adaptation to the humid tropics with special reference to the West African Dwarf (WAD) goat.

PubMed

Daramola, J O; Adeloye, A A

2009-10-01

West African Dwarf (WAD) goats are widely distributed in the subhumid and humid zones of Africa but are particularly associated with less favourable environments. Adaptive features such as feeding behaviour, efficiency of feed use and disease tolerance enable WAD goats to thrive on natural resources left untouched by other domestic ruminants. In marginal environments this goat remains the only domestic species that is able to survive. Among its physiological features small body size and low metabolic requirements are important traits that enable the animal to minimize its requirements in area or season where food sources are limited in quality and quantity. Specialized feeding behaviour and an efficient digestive system enable the animal to maximize food intake. Coat colour plays an important role in the evolved adaptation of this goat type. Reproductive fitness as manifested by prolific breeding is a major factor of adaptation. Defence mechanisms against infectious agents enable this type to thrive well in the hot humid tropics. The mechanisms involved in the regulation of these physiological functions of WAD goat are discussed. An understanding of these mechanisms could result in the development of improved techniques for enhancing goat productivity in humid environments.

Locomotor adaptability in persons with unilateral transtibial amputation.

PubMed

Darter, Benjamin J; Bastian, Amy J; Wolf, Erik J; Husson, Elizabeth M; Labrecque, Bethany A; Hendershot, Brad D

2017-01-01

Locomotor adaptation enables walkers to modify strategies when faced with challenging walking conditions. While a variety of neurological injuries can impair locomotor adaptability, the effect of a lower extremity amputation on adaptability is poorly understood. Determine if locomotor adaptability is impaired in persons with unilateral transtibial amputation (TTA). The locomotor adaptability of 10 persons with a TTA and 8 persons without an amputation was tested while walking on a split-belt treadmill with the parallel belts running at the same (tied) or different (split) speeds. In the split condition, participants walked for 15 minutes with the respective belts moving at 0.5 m/s and 1.5 m/s. Temporal spatial symmetry measures were used to evaluate reactive accommodations to the perturbation, and the adaptive/de-adaptive response. Persons with TTA and the reference group of persons without amputation both demonstrated highly symmetric walking at baseline. During the split adaptation and tied post-adaptation walking both groups responded with the expected reactive accommodations. Likewise, adaptive and de-adaptive responses were observed. The magnitude and rate of change in the adaptive and de-adaptive responses were similar for persons with TTA and those without an amputation. Furthermore, adaptability was no different based on belt assignment for the prosthetic limb during split adaptation walking. Reactive changes and locomotor adaptation in response to a challenging and novel walking condition were similar in persons with TTA to those without an amputation. Results suggest persons with TTA have the capacity to modify locomotor strategies to meet the demands of most walking conditions despite challenges imposed by an amputation and use of a prosthetic limb.

How do clarinet players adjust the resonances of their vocal tracts for different playing effects?

NASA Astrophysics Data System (ADS)

Fritz, Claudia; Wolfe, Joe

2005-11-01

In a simple model, the reed of the clarinet is mechanically loaded by the series combination of the acoustical impedances of the instrument itself and of the player's airway. Here we measure the complex impedance spectrum of players' airways using an impedance head adapted to fit inside a clarinet mouthpiece. A direct current shunt with high acoustical resistance allows players to blow normally, so the players can simulate the tract condition under playing conditions. The reproducibility of the results suggest that the players' ``muscle memory'' is reliable for this task. Most players use a single, highly stable vocal tract configuration over most of the playing range, except for the altissimo register. However, this ``normal'' configuration varies substantially among musicians. All musicians change the configuration, often drastically for ``special effects'' such as glissandi and slurs: the tongue is lowered and the impedance magnitude reduced when the player intends to lower the pitch or to slur downwards, and vice versa.

Dynamic analysis of geometrically non-linear three-dimensional beams under moving mass

NASA Astrophysics Data System (ADS)

Zupan, E.; Zupan, D.

2018-01-01

In this paper, we present a coupled dynamic analysis of a moving particle on a deformable three-dimensional frame. The presented numerical model is capable of considering arbitrary curved and twisted initial geometry of the beam and takes into account geometric non-linearity of the structure. Coupled with dynamic equations of the structure, the equations of moving particle are solved. The moving particle represents the dynamic load and varies the mass distribution of the structure and at the same time its path is adapting due to deformability of the structure. A coupled geometrically non-linear behaviour of beam and particle is studied. The equation of motion of the particle is added to the system of the beam dynamic equations and an additional unknown representing the coordinate of the curvilinear path of the particle is introduced. The specially designed finite-element formulation of the three-dimensional beam based on the weak form of consistency conditions is employed where only the boundary conditions are affected by the contact forces.

Immunosenescence in vertebrates and invertebrates.

PubMed

Müller, Ludmila; Fülöp, Tamas; Pawelec, Graham

2013-04-02

There is an established consensus that it is primarily the adaptive arm of immunity, and the T cell subset in particular, that is most susceptible to the deleterious changes with age known as "immunosenescence". Can we garner any clues as to why this might be by considering comparative immunology and the evolutionary emergence of adaptive and innate immunity? The immune system is assumed to have evolved to protect the organism against pathogens, but the way in which this is accomplished is different in the innate-vs-adaptive arms, and it is unclear why the latter is necessary. Are there special characteristics of adaptive immunity which might make the system more susceptible to age-associated dysfunction? Given recent accumulating findings that actually there are age-associated changes to innate immunity and that these are broadly similar in vertebrates and invertebrates, we suggest here that it is the special property of memory in the adaptive immune system which results in the accumulation of cells with a restricted receptor repertoire, dependent on the immunological history of the individual's exposures to pathogens over the lifetime, and which is commonly taken as a hallmark of "immunosenescence". However, we further hypothesize that this immunological remodelling per se does not necessarily convey a disadvantage to the individual (ie. is not necessarily "senescence" if it is not deleterious). Indeed, under certain circumstances, or potentially even as a rule, this adaptation to the individual host environment may confer an actual survival advantage.

Cultural Adaptations: Conceptual, Ethical, Contextual, and Methodological Issues for Working with Ethnocultural and Majority-World Populations.

PubMed

Bernal, Guillermo; Adames, Cristina

2017-08-01

Mayor advancements have been achieved in research on the cultural adaptation of prevention and treatment interventions that are conducted with diverse ethnocultural groups. This commentary addresses conceptual, ethical, contextual, and methodological issues related to cultural adaptations. The articles in this special issue represent a major contribution to the study of cultural adaptations in prevention science. We frame our analysis of fidelity to core intervention components using a conceptual approach that examines (a) the propositional model (theory of change), (b) the procedural model (theory of action, methods), and (c) the philosophical assumptions that undergird these models. Regarding ethics, we caution against imposing the norms, values, and world views of the Western dominant society onto vulnerable populations such as ethnocultural groups. Given that the assumption of universality in behavioral science has been questioned, and as randomized clinical trials (RCTs) seldom examine the ecological validity of evidence-based interventions and treatments (EBI/T), imposing such interventions onto ethnocultural groups is problematic since these interventions contain values, norms, beliefs, and worldviews that may be contrary to those held by many ethnocultural groups. Regarding methods, several innovative designs are discussed that serve as alternatives to the RCT and represent an important contribution to prevention science. Also, we discuss guidelines for conducting cultural adaptations. Finally, the articles in this special issue make a major contribution to the growing field of cultural adaptation of preventive interventions with ethnocultural groups and majority-world populations.

[Some special indications for wearing contact lenses (author's transl)].

PubMed

Müller, K

1978-12-01

The typical distinguishing features of special cases which require contact lenses for satisfactory vision are described. Hence in the first case with anisometria associated with irregular astigmatism of one eye, to which a toric soft contact lens was adapted. In the second case a visual acuity of only 0,6 monocular was attained with the best spectacle lens, however with contact lense the visual acuity was 1.25. Here a verdict from a social court is mentioned, which obliged the sickness insurance to take over the costs for such a case. In the third case the adaptation of contact lenses was undertaken after radical bilateral keratoplasty because of parenchymatous keratitis, and an improvement in visual acuity of at least 400% resulted.

Specialized Proresolving Mediators in Innate and Adaptive Immune Responses in Airway Diseases.

PubMed

Krishnamoorthy, Nandini; Abdulnour, Raja-Elie E; Walker, Katherine H; Engstrom, Braden D; Levy, Bruce D

2018-07-01

Airborne pathogens and environmental stimuli evoke immune responses in the lung. It is critical to health that these responses be controlled to prevent tissue damage and the compromise of organ function. Resolution of inflammation is a dynamic process that is coordinated by biochemical and cellular mechanisms. Recently, specialized proresolving mediators (SPMs) have been identified in resolution exudates. These molecules orchestrate anti-inflammatory and proresolving actions that are cell type specific. In this review, we highlight SPM biosynthesis, the influence of SPMs on the innate and adaptive immune responses in the lung, as well as recent insights from SPMs on inflammatory disease pathophysiology. Uncovering these mediators and cellular mechanisms for resolution is providing new windows into physiology and disease pathogenesis.

Adaptive identification of vessel's added moments of inertia with program motion

NASA Astrophysics Data System (ADS)

Alyshev, A. S.; Melnikov, V. G.

2018-05-01

In this paper, we propose a new experimental method for determining the moments of inertia of the ship model. The paper gives a brief review of existing methods, a description of the proposed method and experimental stand, test procedures and calculation formulas and experimental results. The proposed method is based on the energy approach with special program motions. The ship model is fixed in a special rack consisting of a torsion element and a set of additional servo drives with flywheels (reactive wheels), which correct the motion. The servo drives with an adaptive controller provide the symmetry of the motion, which is necessary for the proposed identification procedure. The effectiveness of the proposed approach is confirmed by experimental results.

Fast spacecraft adaptive attitude tracking control through immersion and invariance design

NASA Astrophysics Data System (ADS)

Wen, Haowei; Yue, Xiaokui; Li, Peng; Yuan, Jianping

2017-10-01

This paper presents a novel non-certainty-equivalence adaptive control method for the attitude tracking control problem of spacecraft with inertia uncertainties. The proposed immersion and invariance (I&I) based adaptation law provides a more direct and flexible approach to circumvent the limitations of the basic I&I method without employing any filter signal. By virtue of the adaptation high-gain equivalence property derived from the proposed adaptive method, the closed-loop adaptive system with a low adaptation gain could recover the high adaptation gain performance of the filter-based I&I method, and the resulting control torque demands during the initial transient has been significantly reduced. A special feature of this method is that the convergence of the parameter estimation error has been observably improved by utilizing an adaptation gain matrix instead of a single adaptation gain value. Numerical simulations are presented to highlight the various benefits of the proposed method compared with the certainty-equivalence-based control method and filter-based I&I control schemes.

78 FR 14005 - Special Conditions: Embraer S.A., Model EMB-550 Airplanes; Flight Envelope Protection: Pitch and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-04

...-1211; Special Conditions No. 25-486-SC] Special Conditions: Embraer S.A., Model EMB-550 Airplanes... Embraer S.A. Model EMB-550 airplane. This airplane will have a novel or unusual design feature associated...: Background On May 14, 2009, Embraer S.A. applied for a type certificate for their new Model EMB-550 airplane...

78 FR 67291 - Special Conditions: Bombardier Inc., Models BD-500-1A10 and BD-500-1A11 Series Airplanes; Design...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-12

... have a novel or unusual design feature associated with an electronic flight control system that... because of a novel or unusual design feature, special conditions are prescribed under the provisions of... same or similar novel or unusual design feature, the special conditions would also apply to the other...

Calcareous nannofossil assemblage changes across the Paleocene-Eocene thermal maximum: Evidence from a shelf setting

USGS Publications Warehouse

Self-Trail, Jean M.; Powars, David S.; Watkins, David K.; Wandless, Gregory A.

2012-01-01

Biotic response of calcareous nannoplankton to abrupt warming across the Paleocene/Eocene boundary reflects a primary response to climatically induced parameters including increased continental runoff of freshwater, global acidification of seawater, high sedimentation rates, and calcareous nannoplankton assemblage turnover. We identify ecophenotypic nannofossil species adapted to low pH conditions (Discoaster anartios, D. araneus, Rhomboaster spp.), excursion taxa adapted to the extremely warm climatic conditions (Bomolithus supremus and Coccolithus bownii), three species of the genus Toweius (T. serotinus, T. callosus, T. occultatus) adapted to warm, rather than cool, water conditions, opportunists adapted to high productivity conditions (Coronocyclus bramlettei, Neochiastozygus junctus), and species adapted to oligotropic and/or cool‐water conditions that went into refugium during the PETM (Zygrablithus bijugatus, Calcidiscus? parvicrucis and Chiasmolithus bidens). Discoaster anartios was adapted to meso- to eutrophic, rather than oligotrophic, conditions. Comparison of these data to previous work on sediments deposited on shelf settings suggests that local conditions such as high precipitation rates and possible increase in major storms such as hurricanes resulted in increased continental runoff and high sedimentation rates that affected assemblage response to the PETM.

Tissue adaptation: Implications for gut immunity and tolerance

PubMed Central

2017-01-01

Tissue adaptation is an intrinsic component of immune cell development, influencing both resistance to pathogens and tolerance. Chronically stimulated surfaces of the body, in particular the gut mucosa, are the major sites where immune cells traffic and reside. Their adaptation to these environments requires constant discrimination between natural stimulation coming from harmless microbiota and food, and pathogens that need to be cleared. This review will focus on the adaptation of lymphocytes to the gut mucosa, a highly specialized environment that can help us understand the plasticity of leukocytes arriving at various tissue sites and how tissue-related factors operate to shape immune cell fate and function. PMID:28432200

Mode-field adapter for tapered-fiber-bundle signal and pump combiners.

PubMed

Koška, Pavel; Baravets, Yauhen; Peterka, Pavel; Bohata, Jan; Písařík, Michael

2015-02-01

We report on a novel mode-field adapter that is proposed to be incorporated inside tapered fused-fiber-bundle pump and signal combiners for high-power double-clad fiber lasers. Such an adapter allows optimization of signal-mode-field matching on the input and output fibers. Correspondingly, losses of the combiner signal branch are significantly reduced. The mode-field adapter optimization procedure is demonstrated on a combiner based on commercially available fibers. Signal wavelengths of 1.55 and 2 μm are considered. The losses can be further improved by using specially designed intermediate fiber and by dopant diffusion during splicing as confirmed by preliminary experimental results.

Bridging the Gap: Adaptive Games and Student-Centered VLEs

NASA Astrophysics Data System (ADS)

Del Blanco, Ángel; Torrente, Javier; Moreno-Ger, Pablo; Fernández-Manjón, Baltasar

The widely used e-learning technology is facing new challenges such as how to produce student-centered systems that can be adapted to the needs of each student. Those objectives should be met in a standard compliant way to simplify general adoption. In this context, educational videogames are proposed as an ideal medium to facilitate adaptation and tracking of the students’ performance for assessment purposes. However, there are still barriers between the gaming and e-learning worlds preventing their mutual interaction. In this paper we propose a middleware to bridge this gap, integrating adaptive educational videogames in e-learning environments with a special focus on the ongoing standardization efforts.

Probabilistic modelling to assess exposure to three artificial sweeteners of young Irish patients aged 1-3 years with PKU and CMPA.

PubMed

O'Sullivan, Aaron J; Pigat, Sandrine; O'Mahony, Cian; Gibney, Michael J; McKevitt, Aideen I

2016-11-01

The choice of suitable normal foods is limited for individuals with particular medical conditions, e.g., inborn errors of metabolism (phenylketonuria - PKU) or severe cow's milk protein allergy (CMPA). Patients may have dietary restrictions and exclusive or partial replacement of specific food groups with specially formulated products to meet particular nutrition requirements. Artificial sweeteners are used to improve the appearance and palatability of such food products to avoid food refusal and ensure dietary adherence. Young children have a higher risk of exceeding acceptable daily intakes for additives than adults due to higher food intakes kg -1 body weight. The Budget Method and EFSA's Food Additives Intake Model (FAIM) are not equipped to assess partial dietary replacement with special formulations as they are built on data from dietary surveys of consumers without special medical requirements impacting the diet. The aim of this study was to explore dietary exposure modelling as a means of estimating the intake of artificial sweeteners by young PKU and CMPA patients aged 1-3 years. An adapted validated probabilistic model (FACET) was used to assess patients' exposure to artificial sweeteners. Food consumption data were derived from the food consumption survey data of healthy young children in Ireland from the National Preschool and Nutrition Survey (NPNS, 2010-11). Specially formulated foods for special medical purposes were included in the exposure model to replace restricted foods. Inclusion was based on recommendations for adequate protein intake and dietary adherence data. Exposure assessment results indicated that young children with PKU and CMPA have higher relative average intakes of artificial sweeteners than healthy young children. The reliability and robustness of the model in the estimation of patient additive exposures was further investigated and provides the first exposure estimates for these special populations.

Fast online generalized multiscale finite element method using constraint energy minimization

NASA Astrophysics Data System (ADS)

Chung, Eric T.; Efendiev, Yalchin; Leung, Wing Tat

2018-02-01

Local multiscale methods often construct multiscale basis functions in the offline stage without taking into account input parameters, such as source terms, boundary conditions, and so on. These basis functions are then used in the online stage with a specific input parameter to solve the global problem at a reduced computational cost. Recently, online approaches have been introduced, where multiscale basis functions are adaptively constructed in some regions to reduce the error significantly. In multiscale methods, it is desired to have only 1-2 iterations to reduce the error to a desired threshold. Using Generalized Multiscale Finite Element Framework [10], it was shown that by choosing sufficient number of offline basis functions, the error reduction can be made independent of physical parameters, such as scales and contrast. In this paper, our goal is to improve this. Using our recently proposed approach [4] and special online basis construction in oversampled regions, we show that the error reduction can be made sufficiently large by appropriately selecting oversampling regions. Our numerical results show that one can achieve a three order of magnitude error reduction, which is better than our previous methods. We also develop an adaptive algorithm and enrich in selected regions with large residuals. In our adaptive method, we show that the convergence rate can be determined by a user-defined parameter and we confirm this by numerical simulations. The analysis of the method is presented.

Thermal niche evolution of functional traits in a tropical marine phototroph.

PubMed

Baker, Kirralee G; Radford, Dale T; Evenhuis, Christian; Kuzhiumparam, Unnikrishnan; Ralph, Peter J; Doblin, Martina A

2018-06-14

Land-based plants and ocean-dwelling microbial phototrophs known as phytoplankton, are together responsible for almost all global primary production. Habitat warming associated with anthropogenic climate change has detrimentally impacted marine primary production, with the effects observed on regional and global scales. In contrast to slower-growing higher plants, there is considerable potential for phytoplankton to evolve rapidly with changing environmental conditions. The energetic constraints associated with adaptation in phytoplankton are not yet understood, but are central to forecasting how global biogeochemical cycles respond to contemporary ocean change. Here, we demonstrate a number of potential trade-offs associated with high-temperature adaptation in a tropical microbial eukaryote, Amphidinium massartii (dinoflagellate). Most notably, the population became high-temperature specialized (higher fitness within a narrower thermal envelope and higher thermal optimum), and had a greater nutrient requirement for carbon, nitrogen and phosphorus. Evidently, the energetic constraints associated with living at elevated temperature alter competiveness along other environmental gradients. While high-temperature adaptation led to an irreversible change in biochemical composition (i.e., an increase in fatty acid saturation), the mechanisms underpinning thermal evolution in phytoplankton remain unclear, and will be crucial to understanding whether the trade-offs observed here are species-specific or are representative of the evolutionary constraints in all phytoplankton. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

Transcriptional and translational regulation by RNA thermometers, riboswitches and the sRNA DsrA in Escherichia coli O157:H7 Sakai under combined cold and osmotic stress adaptation.

PubMed

Hücker, Sarah Maria; Simon, Svenja; Scherer, Siegfried; Neuhaus, Klaus

2017-01-01

The enteric pathogen Escherichia coli O157:H7 Sakai (EHEC) is able to grow at lower temperatures compared to commensal E. coli Growth at environmental conditions displays complex challenges different to those in a host. EHEC was grown at 37°C and at 14°C with 4% NaCl, a combination of cold and osmotic stress as present in the food chain. Comparison of RNAseq and RIBOseq data provided a snap shot of ongoing transcription and translation, differentiating transcriptional and post-transcriptional gene regulation, respectively. Indeed, cold and osmotic stress related genes are simultaneously regulated at both levels, but translational regulation clearly dominates. Special emphasis was given to genes regulated by RNA secondary structures in their 5 ' UTRs, such as RNA thermometers and riboswitches, or genes controlled by small RNAs encoded in trans The results reveal large differences in gene expression between short-time shock compared to adaptation in combined cold and osmotic stress. Whereas the majority of cold shock proteins, such as CspA, are translationally downregulated after adaptation, many osmotic stress genes are still significantly upregulated mainly translationally, but several also transcriptionally. © FEMS 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Model reference adaptive control of robots

NASA Technical Reports Server (NTRS)

Steinvorth, Rodrigo

1991-01-01

This project presents the results of controlling two types of robots using new Command Generator Tracker (CGT) based Direct Model Reference Adaptive Control (MRAC) algorithms. Two mathematical models were used to represent a single-link, flexible joint arm and a Unimation PUMA 560 arm; and these were then controlled in simulation using different MRAC algorithms. Special attention was given to the performance of the algorithms in the presence of sudden changes in the robot load. Previously used CGT based MRAC algorithms had several problems. The original algorithm that was developed guaranteed asymptotic stability only for almost strictly positive real (ASPR) plants. This condition is very restrictive, since most systems do not satisfy this assumption. Further developments to the algorithm led to an expansion of the number of plants that could be controlled, however, a steady state error was introduced in the response. These problems led to the introduction of some modifications to the algorithms so that they would be able to control a wider class of plants and at the same time would asymptotically track the reference model. This project presents the development of two algorithms that achieve the desired results and simulates the control of the two robots mentioned before. The results of the simulations are satisfactory and show that the problems stated above have been corrected in the new algorithms. In addition, the responses obtained show that the adaptively controlled processes are resistant to sudden changes in the load.

Differential transfer processes in incremental visuomotor adaptation.

PubMed

Seidler, Rachel D

2005-01-01

Visuomotor adaptive processes were examined by testing transfer of adaptation between similar conditions. Participants made manual aiming movements with a joystick to hit targets on a computer screen, with real-time feedback display of their movement. They adapted to three different rotations of the display in a sequential fashion, with a return to baseline display conditions between rotations. Adaptation was better when participants had prior adaptive experiences. When performance was assessed using direction error (calculated at the time of peak velocity) and initial endpoint error (error before any overt corrective actions), transfer was greater when the final rotation reflected an addition of previously experienced rotations (adaptation order 30 degrees rotation, 15 degrees, 45 degrees) than when it was a subtraction of previously experienced conditions (adaptation order 45 degrees rotation, 15 degrees, 30 degrees). Transfer was equal regardless of adaptation order when performance was assessed with final endpoint error (error following any discrete, corrective actions). These results imply the existence of multiple independent processes in visuomotor adaptation.

Operant Conditioning: A Tool for Special Physical Educators in the 1980s.

ERIC Educational Resources Information Center

Dunn, John M.; French, Ron

1982-01-01

The usefulness of operant conditioning for the special physical educator in managing behavior problems is pointed out, and steps to follow in applying operant conditioning techniques are outlined. (SB)

Inspiration for wing design: how forelimb specialization enables active flight in modern vertebrates.

PubMed

Chin, Diana D; Matloff, Laura Y; Stowers, Amanda Kay; Tucci, Emily R; Lentink, David

2017-06-01

Harnessing flight strategies refined by millions of years of evolution can help expedite the design of more efficient, manoeuvrable and robust flying robots. This review synthesizes recent advances and highlights remaining gaps in our understanding of how bird and bat wing adaptations enable effective flight. Included in this discussion is an evaluation of how current robotic analogues measure up to their biological sources of inspiration. Studies of vertebrate wings have revealed skeletal systems well suited for enduring the loads required during flight, but the mechanisms that drive coordinated motions between bones and connected integuments remain ill-described. Similarly, vertebrate flight muscles have adapted to sustain increased wing loading, but a lack of in vivo studies limits our understanding of specific muscular functions. Forelimb adaptations diverge at the integument level, but both bird feathers and bat membranes yield aerodynamic surfaces with a level of robustness unparalleled by engineered wings. These morphological adaptations enable a diverse range of kinematics tuned for different flight speeds and manoeuvres. By integrating vertebrate flight specializations-particularly those that enable greater robustness and adaptability-into the design and control of robotic wings, engineers can begin narrowing the wide margin that currently exists between flying robots and vertebrates. In turn, these robotic wings can help biologists create experiments that would be impossible in vivo . © 2017 The Author(s).

38 CFR 21.216 - Special equipment.

Code of Federal Regulations, 2010 CFR

2010-07-01

... aids to closed-circuit TV systems which amplify reading material for veterans with severe visual impairments. (3) Modifications to improve access. This category includes adaptations of environment not...

10 CFR 600.304 - Special award conditions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Special award conditions. 600.304 Section 600.304 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS FINANCIAL ASSISTANCE RULES Administrative Requirements for Grants and Cooperative Agreements With For-Profit Organizations General § 600.304 Special...

Military Curricula for Vocational & Technical Education. Basic Electricity and Electronics. CANTRAC A-100-0010. Module 33: Special Devices. Study Booklet.

ERIC Educational Resources Information Center

Chief of Naval Education and Training Support, Pensacola, FL.

This individualized learning module on special devices is one in a series of modules for a course in basic electricity and electronics. The course is one of a number of military-developed curriculum packages selected for adaptation to vocational instructional and curriculum development in a civilian setting. Four lessons are included in the…

Military Curricula for Vocational & Technical Education. Basic Electricity and Electronics. CANTRAC A-100-0010. Module 25: Special Devices. Study Booklet.

ERIC Educational Resources Information Center

Chief of Naval Education and Training Support, Pensacola, FL.

This individualized learning module on special devices is one in a series of modules for a course in basic electricity and electronics. The course is one of a number of military-developed curriculum packages selected for adaptation to vocational instructional and curriculum development in a civilian setting. Two lessons are included in the module:…

A Natural Variation Study of Engagement and Confidence among Parents of Learners with Special Educational Needs and Disabilities (SEND)

ERIC Educational Resources Information Center

Barlow, Alexandra; Humphrey, Neil

2012-01-01

Parents' involvement in their children's education is known to be an important predictor of a range of adaptive outcomes. For learners with special educational needs and disabilities (SEND), lack of parental engagement and confidence has been highlighted as a problematic issue. Given this, the objectives of the current study were to: (i) determine…

Improving Distance Education for Students with Special Needs: A Qualitative Study of Students' Experiences with an Online Library Research Course

ERIC Educational Resources Information Center

Catalano, Amy

2014-01-01

This article describes a study in which seven students with diverse disabilities participated in a one-credit online library research course which had been adapted to be accessible using the best practices literature on distance education for students with special needs. Students provided feedback on the design of the course and participated in…

Enhancing water stress tolerance improves fitness in biological control strains of Lactobacillus plantarum in plant environments

PubMed Central

Daranas, Núria; Badosa, Esther; Francés, Jesús; Montesinos, Emilio

2018-01-01

Lactobacillus plantarum strains PM411 and TC92 can efficiently control bacterial plant diseases, but their fitness on the plant surface is limited under unfavourable low relative humidity (RH) conditions. To increase tolerance of these strains to water stress, an adaptive strategy was used consisting of hyperosmotic and acidic conditions during growth. Adapted cells had higher survival rates under desiccation than non-adapted cells. Transcript levels and patterns of general stress-related genes increased immediately after the combined-stress adaptation treatment, and remained unaltered or repressed during the desiccation challenge. However, there were differences between strains in the transcription patterns that were in agreement with a better performance of adapted cells of PM411 than TC92 in plant surfaces under low RH environmental conditions. The combined-stress adaptation treatment increased the survival of PM411 cells consistently in different plant hosts in the greenhouse and under field conditions. Stress-adapted cells of PM411 had similar biocontrol potential against bacterial plant pathogens than non-adapted cells, but with less variability within experiments. PMID:29304187

Regime shifts and panarchies in regional scale social-ecological water systems

PubMed Central

Gunderson, Lance; Cosens, Barbara A.; Chaffin, Brian C.; (Tom) Arnold, Craig A.; Fremier, Alexander K.; Garmestani, Ahjond S.; Craig, Robin Kundis; Gosnell, Hannah; Birge, Hannah E.; Allen, Craig R.; Benson, Melinda H.; Morrison, Ryan R.; Stone, Mark C.; Hamm, Joseph A.; Nemec, Kristine; Schlager, Edella; Llewellyn, Dagmar

2018-01-01

In this article we summarize histories of nonlinear, complex interactions among societal, legal, and ecosystem dynamics in six North American water basins, as they respond to changing climate. These case studies were chosen to explore the conditions for emergence of adaptive governance in heavily regulated and developed social-ecological systems nested within a hierarchical governmental system. We summarize resilience assessments conducted in each system to provide a synthesis and reference by the other articles in this special feature. We also present a general framework used to evaluate the interactions between society and ecosystem regimes and the governance regimes chosen to mediate those interactions. The case studies show different ways that adaptive governance may be triggered, facilitated, or constrained by ecological and/or legal processes. The resilience assessments indicate that complex interactions among the governance and ecosystem components of these systems can produce different trajectories, which include patterns of (a) development and stabilization, (b) cycles of crisis and recovery, which includes lurches in adaptation and learning, and (3) periods of innovation, novelty, and transformation. Exploration of cross scale (Panarchy) interactions among levels and sectors of government and society illustrate that they may constrain development trajectories, but may also provide stability during crisis or innovation at smaller scales; create crises, but may also facilitate recovery; and constrain system transformation, but may also provide windows of opportunity in which transformation, and the resources to accomplish it, may occur. The framework is the starting point for our exploration of how law might play a role in enhancing the capacity of social-ecological systems to adapt to climate change. PMID:29780427

Regime shifts and panarchies in regional scale social-ecological water systems.

PubMed

Gunderson, Lance; Cosens, Barbara A; Chaffin, Brian C; Tom Arnold, Craig A; Fremier, Alexander K; Garmestani, Ahjond S; Craig, Robin Kundis; Gosnell, Hannah; Birge, Hannah E; Allen, Craig R; Benson, Melinda H; Morrison, Ryan R; Stone, Mark C; Hamm, Joseph A; Nemec, Kristine; Schlager, Edella; Llewellyn, Dagmar

2017-03-17

In this article we summarize histories of nonlinear, complex interactions among societal, legal, and ecosystem dynamics in six North American water basins, as they respond to changing climate. These case studies were chosen to explore the conditions for emergence of adaptive governance in heavily regulated and developed social-ecological systems nested within a hierarchical governmental system. We summarize resilience assessments conducted in each system to provide a synthesis and reference by the other articles in this special feature. We also present a general framework used to evaluate the interactions between society and ecosystem regimes and the governance regimes chosen to mediate those interactions. The case studies show different ways that adaptive governance may be triggered, facilitated, or constrained by ecological and/or legal processes. The resilience assessments indicate that complex interactions among the governance and ecosystem components of these systems can produce different trajectories, which include patterns of (a) development and stabilization, (b) cycles of crisis and recovery, which includes lurches in adaptation and learning, and (3) periods of innovation, novelty, and transformation. Exploration of cross scale (Panarchy) interactions among levels and sectors of government and society illustrate that they may constrain development trajectories, but may also provide stability during crisis or innovation at smaller scales; create crises, but may also facilitate recovery; and constrain system transformation, but may also provide windows of opportunity in which transformation, and the resources to accomplish it, may occur. The framework is the starting point for our exploration of how law might play a role in enhancing the capacity of social-ecological systems to adapt to climate change.

Regime shifts and panarchies in regional scale social-ecological water systems

USGS Publications Warehouse

Gunderson, Lance; Cosens, Barbara; Chaffin, Brian C.; Arnold, Craig Anthony (Tony); Fremier, Alexander K.; Garmestani, Ahjond S.; Kundis Craig, Robin; Gosnell, Hannah; Birge, Hannah E.; Allen, Craig R.; Benson, Melinda H.; Morrison, Ryan R.; Stone, Mark; Hamm, Joseph A.; Nemec, Kristine T.; Schlager, Edella; Llewellyn, Dagmar

2017-01-01

In this article we summarize histories of nonlinear, complex interactions among societal, legal, and ecosystem dynamics in six North American water basins, as they respond to changing climate. These case studies were chosen to explore the conditions for emergence of adaptive governance in heavily regulated and developed social-ecological systems nested within a hierarchical governmental system. We summarize resilience assessments conducted in each system to provide a synthesis and reference by the other articles in this special feature. We also present a general framework used to evaluate the interactions between society and ecosystem regimes and the governance regimes chosen to mediate those interactions. The case studies show different ways that adaptive governance may be triggered, facilitated, or constrained by ecological and/or legal processes. The resilience assessments indicate that complex interactions among the governance and ecosystem components of these systems can produce different trajectories, which include patterns of (a) development and stabilization, (b) cycles of crisis and recovery, which includes lurches in adaptation and learning, and (3) periods of innovation, novelty, and transformation. Exploration of cross scale (Panarchy) interactions among levels and sectors of government and society illustrate that they may constrain development trajectories, but may also provide stability during crisis or innovation at smaller scales; create crises, but may also facilitate recovery; and constrain system transformation, but may also provide windows of opportunity in which transformation, and the resources to accomplish it, may occur. The framework is the starting point for our exploration of how law might play a role in enhancing the capacity of social-ecological systems to adapt to climate change.

78 FR 75284 - Special Conditions: Bombardier Inc., Models BD-500-1A10 and BD-500-1A11 Series Airplanes; Flight...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-11

... Administration 14 CFR Part 25 [Docket No. FAA-2013-1038; Notice No. 25-13-37-SC] Special Conditions: Bombardier... comments on or before January 27, 2014. ADDRESSES: Send comments identified by docket number FAA-2013-1038... change these special conditions based on the comments we receive. Background On December 10, 2009...

78 FR 28719 - Special Conditions: Cessna Aircraft Company, Model J182T; Diesel Cycle Engine Installation

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-16

...; Special Conditions No. 23-259-SC] Special Conditions: Cessna Aircraft Company, Model J182T; Diesel Cycle..., air cooled, diesel cycle engine that uses turbine (jet) fuel. The Model No. J182T, which is a... engine airplane with a cantilever high wing, with the SMA SR305- 230E-C1 diesel cycle engine and...

Fixed or adapted conditioning intensity for repeated conditioned pain modulation.

PubMed

Hoegh, M; Petersen, K K; Graven-Nielsen, T

2017-12-29

Aims Conditioned pain modulation (CPM) is used to assess descending pain modulation through a test stimulation (TS) and a conditioning stimulation (CS). Due to potential carry-over effects, sequential CPM paradigms might alter the intensity of the CS, which potentially can alter the CPM-effect. This study aimed to investigate the difference between a fixed and adaptive CS intensity on CPM-effect. Methods On the dominant leg of 20 healthy subjects the cuff pressure detection threshold (PDT) was recorded as TS and the pain tolerance threshold (PTT) was assessed on the non-dominant leg for estimating the CS. The difference in PDT before and during CS defined the CPM-effect. The CPM-effect was assessed four times using a CS with intensities of 70% of baseline PTT (fixed) or 70% of PTT measured throughout the session (adaptive). Pain intensity of the conditioning stimulus was assessed on a numeric rating scale (NRS). Data were analyzed with repeated-measures ANOVA. Results No difference was found comparing the four PDTs assessed before CSs for the fixed and the adaptive paradigms. The CS pressure intensity for the adaptive paradigm was increasing during the four repeated assessments (P < 0.01). The pain intensity was similar during the fixed (NRS: 5.8±0.5) and the adjusted paradigm (NRS: 6.0±0.4). The CPM-effect was higher using the fixed condition compared with the adaptive condition (P < 0.05). Conclusions The current study found that sequential CPM paradigms using a fixed conditioning stimulus produced an increased CPM-effect compared with adaptive and increasing conditioning intensities.

Managing the Risks of Extreme Events and Disasters in a Changing Climate: Lessons for Adaptation to Climate Change (Invited)

NASA Astrophysics Data System (ADS)

Mastrandrea, M.; Field, C. B.; Mach, K. J.; Barros, V.

2013-12-01

The IPCC Special Report on Managing the Risks of Extreme Events and Disasters to Advance Climate Change Adaptation, published in 2012, integrates expertise in climate science, disaster risk reduction, and adaptation to inform discussions on how to reduce and manage the risks of extreme events and disasters in a changing climate. Impacts and the risks of disasters are determined by the interaction of the physical characteristics of weather and climate events with the vulnerability of exposed human society and ecosystems. The Special Report evaluates the factors that make people and infrastructure vulnerable to extreme events, trends in disaster losses, recent and future changes in the relationship between climate change and extremes, and experience with a wide range of options used by institutions, organizations, and communities to reduce exposure and vulnerability, and improve resilience, to climate extremes. Actions ranging from incremental improvements in governance and technology to more transformational changes are assessed. The Special Report provides a knowledge base that is also relevant to the broader context of managing the risks of climate change through mitigation, adaptation, and other responses, assessed in the IPCC's Fifth Assessment Report (AR5), to be completed in 2014. These themes include managing risks through an iterative process involving learning about risks and the effectiveness of responses, employing a portfolio of actions tailored to local circumstances but with links from local to global scales, and considering additional benefits of actions such as improving livelihoods and well-being. The Working Group II contribution to the AR5 also examines the ways that extreme events and their impacts contribute to understanding of vulnerabilities and adaptation deficits in the context of climate change, the extent to which impacts of climate change are experienced through changes in the frequency and severity of extremes as opposed to mean changes, and the emergence of risks that are place-based vs. systemic.

Locomotor adaptations of some gelatinous zooplankton.

PubMed

Bone, Q

1985-01-01

Swimming behaviour and locomotor adaptations are described in chaetognaths, larvacean tunicates, some cnidaria, and thaliacean tunicates. The first two groups swim by oscillating a flattened tail, the others by jet propulsion. In chaetognaths, the locomotor muscle fibres are extensively coupled and relatively sparsely innervated, they exhibit compound spike-like potentials. The motoneurons controlling the rhythmic activity of the locomotor muscle lie in a ventral ganglion whose organization is briefly described. Rhythmic swimming bursts in larvaceans are similarly driven by a caudal ganglion near the base of the tail, but each caudal muscle cell is separately innervated by two sets of motor nerves, as well as being coupled to its neighbours. The external epithelium is excitable, and linked to the caudal ganglion by the axons of central cells. Mechanical stimulation of the epithelium evokes receptor potentials followed by action potentials and by bursts of rapid swimming. The trachyline medusa Aglantha and the small siphonophore Chelophyes also show rapid escape responses; in Aglantha these are driven by a specialized giant axon system lacking in other hydromedusae, and in Chelophyes. Slow swimming in Aglantha apparently involves a second nerve supply to the same muscle sheets used in rapid swimming, whereas in Chelophyes slow swimming results from the activity of the smaller posterior nectophore. Slow swimming in siphonophores is more economical than the rapid responses. In the hydrozoan medusa Polyorchis (as in Chelophyes) action potentials in the locomotor muscle sheet change in shape during swimming bursts, and their duration is related to the size of the medusa; they are not simply triggers of muscular contraction. The two groups of thaliacean tunicates are specialized differently. Doliolum is adapted for single rapid jet pulses (during which it achieves instantaneous velocities of 50 body lengths s-l), whilst salps are adapted for slow continuous swimming. The cost of locomotion is greater in Doliolum. Few gelatinous zooplankton show special adaptations both for rapid escape movements, and for slow sustained swimming, those that do deserve further study.

Colorizing SENTINEL-1 SAR Images Using a Variational Autoencoder Conditioned on SENTINEL-2 Imagery

NASA Astrophysics Data System (ADS)

Schmitt, M.; Hughes, L. H.; Körner, M.; Zhu, X. X.

2018-05-01

In this paper, we have shown an approach for the automatic colorization of SAR backscatter images, which are usually provided in the form of single-channel gray-scale imagery. Using a deep generative model proposed for the purpose of photograph colorization and a Lab-space-based SAR-optical image fusion formulation, we are able to predict artificial color SAR images, which disclose much more information to the human interpreter than the original SAR data. Future work will aim at further adaption of the employed procedure to our special case of multi-sensor remote sensing imagery. Furthermore, we will investigate if the low-level representations learned intrinsically by the deep network can be used for SAR image interpretation in an end-to-end manner.

Turbine Design and Analysis for the J-2X Engine Turbopumps

NASA Technical Reports Server (NTRS)

Marcu, Bogdan; Tran, Ken; Dorney, Daniel J.; Schmauch, Preston

2008-01-01

Pratt and Whitney Rocketdyne and NASA Marshall Space Flight Center are developing the advanced upper stage J-2X engine based on the legacy design of the J-2/J-2S family of engines which powered the Apollo missions. The cryogenic propellant turbopumps have been denoted as Mark72-F and Mark72-0 for the fuel and oxidizer side, respectively. Special attention is focused on preserving the essential flight-proven design features while adapting the design to the new turbopump configuration. Advanced 3-D CFD analysis has been employed to verify turbine aero performance at current flow regime boundary conditions and to mitigate risks associated with stresses. A limited amount of redesign and overall configuration modifications allow for a robust design with performance level matching or exceeding requirement.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Meng, Yifei; Zuo, Jian -Min

A diffraction-based technique is developed for the determination of three-dimensional nanostructures. The technique employs high-resolution and low-dose scanning electron nanodiffraction (SEND) to acquire three-dimensional diffraction patterns, with the help of a special sample holder for large-angle rotation. Grains are identified in three-dimensional space based on crystal orientation and on reconstructed dark-field images from the recorded diffraction patterns. Application to a nanocrystalline TiN thin film shows that the three-dimensional morphology of columnar TiN grains of tens of nanometres in diameter can be reconstructed using an algebraic iterative algorithm under specified prior conditions, together with their crystallographic orientations. The principles can bemore » extended to multiphase nanocrystalline materials as well. Furthermore, the tomographic SEND technique provides an effective and adaptive way of determining three-dimensional nanostructures.« less

The technology applying of inflatable devices to access adaptation, movement and landing descent vehicle from Martian environment to the Earth conditions

NASA Astrophysics Data System (ADS)

Koryanov, Vsevolod V.; Kazakovtsev, Victor P.

2017-07-01

At present, the idea has emerged to use special inflatable braking device (IBD) which permits to implement the landing vehicle (LV) "soft" landing on the planet's surface without a parachute system. Braking device (BD) unfolds still at the extra-atmospheric flight stage to provide the LV passive stabilisation, and the entire apparatus together with the braking device is twisted around its longitudinal axis. The advantage of an inflatable BD over traditional non-rigid brakes - parachutes is that it can be used at the atmospheric stage of the descent, starting from hypersonic speeds, and ending subsonic ones. These main theses are implemented in the project MetNet and its sequel project RITD, using Entry, Descent and Landing System (EDLS) system [1].

[Why is obstructive sleep apnea (OSA) a cardiovascular risk factor?].

PubMed

Koehler, U; Becker, H F; Gross, V; Reinke, C; Penzel, T; Schäfer, H; Vogelmeier, C

2003-12-01

Patients with obstructive sleep apnea (OSA) frequently suffer from cardiovascular diseases. Mechanisms like intrathoracic pressure variations, changes in blood gases (hypoxia), arousals and neurohumeral adaptation mechanisms, combined with breathing disorders are causing these cardiovascular sequelae. In particular repetitive hypoxemia and activation of the sympathetic nervous system have to be considered as stressors for the cardiovascular system. Special clinical findings should take OSA into consideration as a differential diagnosis. A systematic anamnesis with questions to daytime conditions (hypersomnia, decrease of performance), snoring and apneas while sleeping is easy to ascertain, and will lead to the correct diagnosis in more than 90% of cases. The extent and need for therapy should be assessed by three criteria: 1) daytime symptoms, 2) the extent of breathing disorder and 3) cardiovascular comorbidity.

Curriculum Adaptation in Special Schools for Students with Intellectual Disabilities (SID): A Case Study of Project Learning in One SID School in Hong Kong

ERIC Educational Resources Information Center

Zhang, Jia-Wei; Wong, Lam; Chan, Tak-Hang; Chiu, Chi-Shing

2014-01-01

Using a qualitative case study approach, the authors analyzed the curriculum adaptation process for one project learning activity in School K, which is a SID school in the context of school-university collaboration. Multiple sources of data were collected for triangulation, including interviews, documents and observations. Curriculum adaptation…

Secondary Special Education. Part I: The "Stepping Stone Model" Designed for Secondary Learning Disabled Students. Part II: Adapting Materials and Curriculum.

ERIC Educational Resources Information Center

Fox, Barbara

The paper describes the Stepping Stone Model, a model for the remediation and mainstreaming of secondary learning disabled students and the adaptation of curriculum and materials for the model. The Stepping Stone Model is designed to establish the independence of students in the mainstream through content reading. Five areas of concern common to…

Comparative evaluation of effects of bleaching on color stability and marginal adaptation of discolored direct and indirect composite laminate veneers under in vivo conditions.

PubMed

Jain, Veena; Das, Taposh K; Pruthi, Gunjan; Shah, Naseem; Rajendiran, Suresh

2015-01-01

Change in color and loss of marginal adaptation of tooth colored restorative materials is not acceptable. Bleaching is commonly used for treating discolored teeth. However, the literature is scanty regarding its effect on color and marginal adaptation of direct and indirect composite laminate veneers (CLVs) under in vivo conditions. Purpose of the study was to determine the effect of bleaching on color change and marginal adaptation of direct and indirect CLVs over a period of time when exposed to the oral environment. For this purpose, a total of 14 subjects irrespective of age and sex indicated for CLV restorations on maxillary anterior teeth were selected following the inclusion and exclusion criteria. For each subject, indirect CLVs were fabricated and looted in the first quadrant (Group 1) and direct CLV's (Group 2), were given in the second quadrant. Color change was assessed clinically using intra-oral digital spectrophotometer and marginal adaptation was assessed on epoxy resin replica of the tooth-restoration interface under scanning electron microscope. After 6 months, the subjects underwent a home bleaching regimen for 14 days using 10% carbamide peroxide. The assessment of color change and marginal adaptation was done at 6 months after veneering (0-180 days), immediately after the bleaching regimen (0-194 days) and 3 months after the bleaching regimen (0-284 days). The difference in median color change (ΔE) between the groups was tested using Wilcoxon rank sum test while the median color change with time within the groups was tested using Wilcoxon signed rank test. The difference in the rates of marginal adaptation was tested between the groups using Chi-square/Fisher's exact test. Bleaching led to statistically significant color change at cervical (CE), middle and incisal (IE) regions when direct and indirect composites were compared (P < 0.05). During intra-group comparison, direct CLV's showed significant color change at CE and IE regions when ΔE was compared at 180 days and 284 days (CE 10 vs. CE 30, P = 0.008, IE 10 vs. IE 30, P = 0.003). No significant differences were found when within group comparison was made for indirect laminates. Intergroup comparison between the groups showed significant difference in marginal adaptation at CE margin at all.time points (at baseline, P = 0.005; at 180 days, P = 0.007; 194 days, P = 0.025; at 284 days, P = 0.067). After bleaching, indirect CLVs performed better in terms of color stability whereas direct CLVs performed better in terms of marginal adaptation. Indirect composites should be preferred to direct composites as veneering materials as they have better color stability. Special attention should be given to their marginal adaptation especially in the CE region. Bleaching should be avoided in patients with composite restorations in the mouth.

Capturing the superorganism: a formal theory of group adaptation.

PubMed

Gardner, A; Grafen, A

2009-04-01

Adaptation is conventionally regarded as occurring at the level of the individual organism. However, in recent years there has been a revival of interest in the possibility for group adaptations and superorganisms. Here, we provide the first formal theory of group adaptation. In particular: (1) we clarify the distinction between group selection and group adaptation, framing the former in terms of gene frequency change and the latter in terms of optimization; (2) we capture the superorganism in the form of a 'group as maximizing agent' analogy that links an optimization program to a model of a group-structured population; (3) we demonstrate that between-group selection can lead to group adaptation, but only in rather special circumstances; (4) we provide formal support for the view that between-group selection is the best definition for 'group selection'; and (5) we reveal that mechanisms of conflict resolution such as policing cannot be regarded as group adaptations.

Selecting Effective Means to Any End: Futures and Ethics of Persuasion Profiling

NASA Astrophysics Data System (ADS)

Kaptein, Maurits; Eckles, Dean

Interactive persuasive technologies can and do adapt to individuals. Existing systems identify and adapt to user preferences within a specific domain: e.g., a music recommender system adapts its recommended songs to user preferences. This paper is concerned with adaptive persuasive systems that adapt to individual differences in the effectiveness of particular means, rather than selecting different ends. We give special attention to systems that implement persuasion profiling - adapting to individual differences in the effects of influence strategies. We argue that these systems are worth separate consideration and raise unique ethical issues for two reasons: (1) their end-independence implies that systems trained in one context can be used in other, unexpected contexts and (2) they do not rely on - and are generally disadvantaged by - disclosing that they are adapting to individual differences. We use examples of these systems to illustrate some ethically and practically challenging futures that these characteristics make possible.

14 CFR § 1260.114 - Special award conditions.

Code of Federal Regulations, 2014 CFR

2014-01-01

....114 Special award conditions. If an applicant or recipient has a history of poor performance, is not... not conformed to the terms and conditions of a previous award, or is not otherwise responsible, NASA...

A comparison of adaptive and adaptable automation under different levels of environmental stress.

PubMed

Sauer, Juergen; Kao, Chung-Shan; Wastell, David

2012-01-01

The effectiveness of different forms of adaptive and adaptable automation was examined under low- and high-stress conditions, in the form of different levels of noise. Thirty-six participants were assigned to one of the three types of variable automation (adaptive event-based, adaptive performance-based and adaptable serving as a control condition). Participants received 3 h of training on a simulation of a highly automated process control task and were subsequently tested during a 4-h session under noise exposure and quiet conditions. The results for performance suggested no clear benefits of one automation control mode over the other two. However, it emerged that participants under adaptable automation adopted a more active system management strategy and reported higher levels of self-confidence than in the two adaptive control modes. Furthermore, the results showed higher levels of perceived workload, fatigue and anxiety for performance-based adaptive automation control than the other two modes. This study compared two forms of adaptive automation (where the automated system flexibly allocates tasks between human and machine) with adaptable automation (where the human allocates the tasks). The adaptable mode showed marginal advantages. This is of relevance, given that this automation mode may also be easier to design.

Peer relations of youth with pediatric conditions and health risks: promoting social support and healthy lifestyles.

PubMed

La Greca, Annette M; Bearman, Karen J; Moore, Hannah

2002-08-01

Peer relations and close friendships play important roles in youngsters' emotional development and take on special significance when a child or adolescent has a chronic disease. This article reviews the key ways that peer relations have been examined in youth with chronic pediatric conditions and specifically focuses on (1) the role of peers and close friends as a source of support, (2) friends' influence on treatment adherence, and (3) peers' and friends' impact on health-promoting and health-risk behaviors. In general, youngsters with chronic conditions do not have more problems in their peer relations than other youth, although children with medical conditions that are stigmatizing or that involve the central nervous system (CNS) may encounter peer difficulties. Social support from friends and classmates appears to facilitate youngsters' disease adaptation and may help with the lifestyle aspects of treatment regimens. Adolescent peer-crowd affiliations (e.g., "brains," "jocks") that are linked with health-promoting behaviors may prove beneficial to youngsters' disease management and health. The findings underscore the need for helping children and adolescents disclose their medical condition to peers in positive ways and for including youngsters' close friends in the treatment process and in school-reentry programs after extended medical care. Additional research is needed to develop strategies for incorporating youngsters' peers and friends into the medical management of youth with chronic pediatric conditions.

Impact of fouling on the decline of aeration efficiency under different operational conditions at WRRFs.

PubMed

Garrido-Baserba, Manel; Asvapathanagul, Pitiporn; Park, Hee-Deung; Kim, Taek-Seung; Baquero-Rodriguez, G Andres; Olson, Betty H; Rosso, Diego

2018-10-15

Biofilm formation influences the most energy-demanding process in the waste water treatment cycle. Biofilm growth on the surface of wastewater aeration diffusers in water resource recovery facilities (WRRFs) can increase the energy requirements up to 50% in less than 2 years. The impact of biofilms in aeration diffusers was quantified and assessed for first time using molecular tools (i.e., Energy-dispersive X-ray, Ra and RMS and Pyrosequencing) and state-of-the-art techniques (i.e., EPS quantification, Hydrophobicity and DNA quantification). To provide a better understanding and quantitative connections between biological activity and aeration energy efficiency, two replicates of the most common diffusers were installed and tested in two different operational conditions (higher and lower organic loading rate processes) during 15 months. Different scenarios and conditions provided for first time comprehensive understanding of the major factors contributing to diffuser fouling. The array of analysis suggested that higher loading conditions can promote specialized microbial populations to halve aeration efficiency parameters (i.e., αF) in comparison to lower loading conditions. Biofilms adapted to certain operational conditions can trigger changes in diffuser membrane properties (i.e., biological enhanced roughness and hydrophobicity) and enhance EPS growth rates. Improved understanding of the effects of scaling, biofouling, aging and microbial population shifts on the decrease in aeration efficiency is provided. Copyright © 2018 Elsevier B.V. All rights reserved.

Tremor

MedlinePlus

... recommend the use of weights, splints, other adaptive equipment, and special plates and utensils for eating. Speech- ... on tremor also is available from the following organizations: International Essential Tremor Foundation P.O. Box 14005 ...

Genetic diversities of MT-ND1 and MT-ND2 genes are associated with high-altitude adaptation in yak.

PubMed

Shi, Yu; Hu, Yongsong; Wang, Jie; Elzo, Mauricio A; Yang, Xue; Lai, Songjia

2018-04-01

Tibetan yak (Bos grunniens) inhabiting the Qinghai-Tibet Plateau (QTP) where the average altitude is 4000 m, is specially adapted to live at these altitudes. Conversely, cattle (B. taurus) has been found to suffer from high-altitude hypertension or heart failure when exposed to these high altitudes. Two mitochondrial genes, MT-ND1 and MT-ND2, encode two subunits of NADH dehydrogenase play an essential role in the electron transport chain of oxidative phosphorylation (OXPHOS). We sequenced these two mitochondrial genes in two bovine groups (70 Tibetan yaks and 70 Xuanhan cattle) and downloaded 300 sequences of B. taurus (cattle), 93 sequences of B. grunniens (domestic yak), and 2 sequences of B. mutus (wild yak) from NCBI to increase our understanding of the mechanisms of adaptability to hypoxia at high altitudes in yaks compared to cattle. MT-ND1 SNP m.3907 C > T, present in all Tibetan yaks, was positively associated with high-altitude adaptation (p < .0006). Specially, mutation m.3638 A > G present in all cattle, resulting in the termination of transcription, was negatively associated with high-altitude adaptation (p < .0006). Additionally, MT-ND2 SNPs m.4351 G > A and m.5218 C > T also showed positive associations with high-altitude adaptation (p < .0004). MT-ND1 haplotypes H2, H3, H4, H6, and H7 showed positive associations but haplotype H20 had a negative association with high-altitude adaptation (p < .0008). Similarly, MT-ND2 haplotypes Ha1 Ha8, Ha10, and Ha11 were positively associated whereas haplotype Ha2 was negatively associated with adaptability to high-altitudes (p < .0008). Thus, MT-ND1 and MT-ND2 can be considered as candidate genes associated with adaptation to high-altitude environments.

Effects of ordinary and adaptive toys on pre-school children with developmental disabilities.

PubMed

Hsieh, Hsieh-Chun

2008-01-01

Toys help children in mastering developmental tasks. This study investigated toy effect on children with developmental disabilities as they engage in using ordinary and adaptive toys. A single-subject design was used to identify the effects on their toy play abilities. Differences in toy effects between playing ordinary and adaptive toys were examined. Three special education teachers chose ordinary toys and modified ordinary toys. Modified ordinary toys, i.e., adaptive toys, were designed according to the individual disabilities of participating children, treatment goals, and the toy types. Three children with developmental disabilities from pre-schools in Taiwan were enrolled. Appropriate participation of three pre-schoolers increased dramatically in playing adaptive toys during intervention phase. The toy effects demonstrate that when using adaptive toys, children with developmental disabilities may response better during toy play sessions.

Special population planner 4 : an open source release.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kuiper, J.; Metz, W.; Tanzman, E.

2008-01-01

Emergencies like Hurricane Katrina and the recent California wildfires underscore the critical need to meet the complex challenge of planning for individuals with special needs and for institutionalized special populations. People with special needs and special populations often have difficulty responding to emergencies or taking protective actions, and emergency responders may be unaware of their existence and situations during a crisis. Special Population Planner (SPP) is an ArcGIS-based emergency planning system released as an open source product. SPP provides for easy production of maps, reports, and analyses to develop and revise emergency response plans. It includes tools to manage amore » voluntary registry of data for people with special needs, integrated links to plans and documents, tools for response planning and analysis, preformatted reports and maps, and data on locations of special populations, facility and resource characteristics, and contacts. The system can be readily adapted for new settings without programming and is broadly applicable. Full documentation and a demonstration database are included in the release.« less

Does ecological specialization transcend scale? Habitat partitioning among individuals and species of Anolis lizards.

PubMed

Kamath, Ambika; Losos, Jonathan B

2017-03-01

Ecological specialization is common across all levels of biological organization, raising the question of whether the evolution of specialization at one scale in a taxon is linked to specialization at other scales. Anolis lizards have diversified repeatedly along axes of habitat use, but it remains unknown if this diversification into habitat use specialists is underlain by individual specialization. From repeated observations of individuals in a population of Anolis sagrei in Florida, we show that the extent of habitat use specialization among individuals is comparable to the extent of specialization in the same traits among ten sympatric Anolis habitat specialist species in Cuba. However, the adaptive correlations between habitat use and morphology commonly seen across species of Anolis were not observed across individuals in the sampled population. Our results therefore suggest that while patterns of ecological specialization can transcend scale, these parallels are the consequence of distinct ecological processes acting at microevolutionary and macroevolutionary scales. © 2016 The Author(s). Evolution © 2016 The Society for the Study of Evolution.

Operant Conditioning for Special Educators.

ERIC Educational Resources Information Center

Pedrini, Bonnie C.; Pedrini, D. T.

The paper briefly explains operant conditioning as it pertains to special educators. Operant conditioning is thought to be an efficient method for modifying student behavior. Using the B. F. Skinner frame of reference, operant conditioning is said to include behavior modification and therapy, programed instruction, and computer assisted and…

24 CFR 3285.315 - Special snow load conditions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... HOUSING AND URBAN DEVELOPMENT MODEL MANUFACTURED HOME INSTALLATION STANDARDS Foundations § 3285.315 Special snow load conditions. (a) General. Foundations for homes designed for and located in areas with roof live loads greater than 40 psf must be designed by the manufacturer for the special snow load...

22 CFR 145.14 - Special award conditions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Special award conditions. 145.14 Section 145.14 Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Pre-Award Requirements § 145.14 Special award...

Evolvability of flower geometry: Convergence in pollinator-driven morphological evolution of flowers.

PubMed

Woźniak, Natalia Joanna; Sicard, Adrien

2018-07-01

Flowers represent a key innovation during plant evolution. Driven by reproductive optimization, evolution of flower morphology has been central in boosting species diversification. In most cases, this has happened through specialized interactions with animal pollinators and subsequent reduction of gene flow between specialized morphs. While radiation has led to an enormous variability in flower forms and sizes, recurrent evolutionary patterns can be observed. Here, we discuss the targets of selection involved in major trends of pollinator-driven flower evolution. We review recent findings on their adaptive values, developmental grounds and genetic bases, in an attempt to better understand the repeated nature of pollinator-driven flower evolution. This analysis highlights how structural innovation can provide flexibility in phenotypic evolution, adaptation and speciation. Copyright © 2017 Elsevier Ltd. All rights reserved.

Kv1 channels and neural processing in vestibular calyx afferents.

PubMed

Meredith, Frances L; Kirk, Matthew E; Rennie, Katherine J

2015-01-01

Potassium-selective ion channels are important for accurate transmission of signals from auditory and vestibular sensory end organs to their targets in the central nervous system. During different gravity conditions, astronauts experience altered input signals from the peripheral vestibular system resulting in sensorimotor dysfunction. Adaptation to altered sensory input occurs, but it is not explicitly known whether this involves synaptic modifications within the vestibular epithelia. Future investigations of such potential plasticity require a better understanding of the electrophysiological mechanisms underlying the known heterogeneity of afferent discharge under normal conditions. This study advances this understanding by examining the role of the Kv1 potassium channel family in mediating action potentials in specialized vestibular afferent calyx endings in the gerbil crista and utricle. Pharmacological agents selective for different sub-types of Kv1 channels were tested on membrane responses in whole cell recordings in the crista. Kv1 channels sensitive to α-dendrotoxin and dendrotoxin-K were found to prevail in the central regions, whereas K(+) channels sensitive to margatoxin, which blocks Kv1.3 and 1.6 channels, were more prominent in peripheral regions. Margatoxin-sensitive currents showed voltage-dependent inactivation. Dendrotoxin-sensitive currents showed no inactivation and dampened excitability in calyces in central neuroepithelial regions. The differential distribution of Kv1 potassium channels in vestibular afferents supports their importance in accurately relaying gravitational and head movement signals through specialized lines to the central nervous system. Pharmacological modulation of specific groups of K(+) channels could help alleviate vestibular dysfunction on earth and in space.

Study and analysis of light characteristics of various sources of radiation by using layout of UVP on a special stand

NASA Astrophysics Data System (ADS)

Nevodovskyi, P. V.; Vidmachenko, A. P.; Geraimchuk, M. D.; Ivakhiv, O. V.

2018-05-01

A special stand was created for research and testing model of a small-sized ultraviolet polarimeter. At this stand, we conducted a series of research works to determine the parameters and some characteristics of different light receivers. These works have allowed us to adapt this model of the device for work on the telescope AZT-2.

Children with Disabilities Playing Musical Instruments: With the Right Adaptations and Help from Their Teachers and Parents, Students with Disabilities Can Play Musical Instruments

ERIC Educational Resources Information Center

McCord, Kimberly; Fitzgerald, Margaret

2006-01-01

In this article, the authors share the story of Stephanie, a dyslexic student who experiences problems reading music. The authors recommend for music teachers to share the list of students wanting to play an instrument with special educators to find out if there are students who are receiving special education services, what their strengths and…

Adaptive Reorganization of German Special Operations Forces

DTIC Science & Technology

2013-12-01

Accordingly, special operations must be commanded and controlled at the highest level to ensure operations remain synchronized with strategic...Ministry of Defense, “White Papers 2006,” German Ministry of Defense, Berlin 2006, 17. 45.Ibid. 46. Franz Joseph Jung , former Federal Minister of the...makers, wishful thinking, and overcontrol of missions executed from afar.”65 In addition, General Carl Stiner, the second Commander in Chief (CINC) of

Expose : procedure and results of the joint experiment verification tests

NASA Astrophysics Data System (ADS)

Panitz, C.; Rettberg, P.; Horneck, G.; Rabbow, E.; Baglioni, P.

The International Space Station will carry the EXPOSE facility accommodated at the universal workplace URM-D located outside the Russian Service Module. The launch will be affected in 2005 and it is planned to stay in space for 1.5 years. The tray like structure will accomodate 2 chemical and 6 biological PI-experiments or experiment systems of the ROSE (Response of Organisms to Space Environment) consortium. EXPOSE will support long-term in situ studies of microbes in artificial meteorites, as well as of microbial communities from special ecological niches, such as endolithic and evaporitic ecosystems. The either vented or sealed experiment pockets will be covered by an optical filter system to control intensity and spectral range of solar UV irradiation. Control of sun exposure will be achieved by the use of individual shutters. To test the compatibility of the different biological systems and their adaptation to the opportunities and constraints of space conditions a profound ground support program has been developed. The procedure and first results of this joint Experiment Verification Tests (EVT) will be presented. The results will be essential for the success of the EXPOSE mission and have been done in parallel with the development and construction of the final hardware design of the facility. The results of the mission will contribute to the understanding of the organic chemistry processes in space, the biological adaptation strategies to extreme conditions, e.g. on early Earth and Mars, and the distribution of life beyond its planet of origin.