Science.gov

Sample records for adaptive strategies employed

  1. Consumer and Employer Strategies for Overcoming Employment Barriers. Technical Report.

    ERIC Educational Resources Information Center

    Crudden, Adele; Williams, Wendy; McBroom, Lynn W.; Moore, J. Elton

    This report on strategies for overcoming employment barriers for persons with visual impairments summarizes comments and suggestions of 7 focus groups comprised of either consumers (n=49) or employers (n=19). The report first reviews the literature concerning employment barriers and how consumers in previous studies suggested these barriers be…

  2. Expressing Adaptation Strategies Using Adaptation Patterns

    ERIC Educational Resources Information Center

    Zemirline, N.; Bourda, Y.; Reynaud, C.

    2012-01-01

    Today, there is a real challenge to enable personalized access to information. Several systems have been proposed to address this challenge including Adaptive Hypermedia Systems (AHSs). However, the specification of adaptation strategies remains a difficult task for creators of such systems. In this paper, we consider the problem of the definition…

  3. Discrepant Stakeholder Perspectives on Graduate Employability Strategies

    ERIC Educational Resources Information Center

    Kinash, Shelley; Crane, Linda; Judd, Madelaine-Marie; Knight, Cecily

    2016-01-01

    A literature review identified 12 strategies that have been empirically linked to improvements in graduate employability. A survey methodology was used to investigate self-reported use and/or perspectives on these strategies among four stakeholder groups. The following questions were asked: to students--What strategies are you using to improve…

  4. Strategies of Adaptive Ability Measurement.

    ERIC Educational Resources Information Center

    Weiss, David J.

    A number of strategies are described for adapting ability test items to individual differences in ability levels of testees. Each strategy consists of a different set of rules for selecting the sequence of test items to be administered to a given testee. Advantages and disadvantages of each strategy are discussed, and research issues unique to the…

  5. An adaptive strategy for controlling chaotic system.

    PubMed

    Cao, Yi-Jia; Hang, Hong-Xian

    2003-01-01

    This paper presents an adaptive strategy for controlling chaotic systems. By employing the phase space reconstruction technique in nonlinear dynamical systems theory, the proposed strategy transforms the nonlinear system into canonical form, and employs a nonlinear observer to estimate the uncertainties and disturbances of the nonlinear system, and then establishes a state-error-like feedback law. The developed control scheme allows chaos control in spite of modeling errors and parametric variations. The effectiveness of the proposed approach has been demonstrated through its applications to two well-known chaotic systems: Duffing oscillator and Rössler chaos.

  6. Employer Health and Productivity Roadmap™ strategy.

    PubMed

    Parkinson, Michael D

    2013-12-01

    The National Institute for Occupational Safety and Health Total Worker Health™ Program defines essential elements of an integrated health protection and health promotion model to improve the health, safety, and performance of employers and employees. The lack of a clear strategy to address the core drivers of poor health, excessive medical costs, and lost productivity has deterred a comprehensive, integrated, and proactive approach to meet these challenges. The Employer Health and Productivity Roadmap™, comprising six interrelated and integrated core elements, creates a framework of shared accountability for both employers and their health and productivity partners to implement and monitor actionable measures that improve health, maximize productivity, and reduce excessive costs. The strategy is most effective when linked to a financially incentivized health management program or consumer-directed health plan insurance benefit design.

  7. Escaping Antiangiogenic Therapy: Strategies Employed by Cancer Cells

    PubMed Central

    Pinto, Mauricio P.; Sotomayor, Paula; Carrasco-Avino, Gonzalo; Corvalan, Alejandro H.; Owen, Gareth I.

    2016-01-01

    Tumor angiogenesis is widely recognized as one of the “hallmarks of cancer”. Consequently, during the last decades the development and testing of commercial angiogenic inhibitors has been a central focus for both basic and clinical cancer research. While antiangiogenic drugs are now incorporated into standard clinical practice, as with all cancer therapies, tumors can eventually become resistant by employing a variety of strategies to receive nutrients and oxygen in the event of therapeutic assault. Herein, we concentrate and review in detail three of the principal mechanisms of antiangiogenic therapy escape: (1) upregulation of compensatory/alternative pathways for angiogenesis; (2) vasculogenic mimicry; and (3) vessel co-option. We suggest that an understanding of how a cancer cell adapts to antiangiogenic therapy may also parallel the mechanisms employed in the bourgeoning tumor and isolated metastatic cells delivering responsible for residual disease. Finally, we speculate on strategies to adapt antiangiogenic therapy for future clinical uses. PMID:27608016

  8. Escaping Antiangiogenic Therapy: Strategies Employed by Cancer Cells.

    PubMed

    Pinto, Mauricio P; Sotomayor, Paula; Carrasco-Avino, Gonzalo; Corvalan, Alejandro H; Owen, Gareth I

    2016-09-06

    Tumor angiogenesis is widely recognized as one of the "hallmarks of cancer". Consequently, during the last decades the development and testing of commercial angiogenic inhibitors has been a central focus for both basic and clinical cancer research. While antiangiogenic drugs are now incorporated into standard clinical practice, as with all cancer therapies, tumors can eventually become resistant by employing a variety of strategies to receive nutrients and oxygen in the event of therapeutic assault. Herein, we concentrate and review in detail three of the principal mechanisms of antiangiogenic therapy escape: (1) upregulation of compensatory/alternative pathways for angiogenesis; (2) vasculogenic mimicry; and (3) vessel co-option. We suggest that an understanding of how a cancer cell adapts to antiangiogenic therapy may also parallel the mechanisms employed in the bourgeoning tumor and isolated metastatic cells delivering responsible for residual disease. Finally, we speculate on strategies to adapt antiangiogenic therapy for future clinical uses.

  9. Combining sustainable energy development and employment strategies

    SciTech Connect

    Olesen, G.B.

    1994-12-31

    International Network for Sustainable Energy--Europe (INforSE--Europe) is developing proposals to focus on the important connections between CO,-abatement strategies and employment. Basically, support for unemployed people in industrialized countries can be used to support job-creating sustainable energy measures. This paper describes the first version of the proposals for the European Union (EU), covering estimates of potential employment effects of wind energy, solar thermal energy, combustible and digestible biomass, and increased energy efficiency in heat and electricity. The result of these first estimates is that these proposals can create directly about 600,000 jobs and by induced effects an additional 1,300,000 jobs lasting for more than 10 years. The proposed elements of a sustainable energy strategy will have a significant role in reducing the unemployment of 17 million persons in EU. Because of reduced expenses of the states for unemployment benefits and increased tax revenue, it is estimated that the states can support the implementation of the proposals with at least 25% of the investments and still have a positive effect on the state budgets, The paper also describes the worldwide INforSE campaign and a number of other NGO activities on environment, energy, and employment.

  10. Unpaid to Salaried Employment: Strategies for Change.

    ERIC Educational Resources Information Center

    Neely, Margery A.; Dees, Diane

    This workshop presentation from the National Vocational Guidance Association Annual Convention consists of two parts--a discussion of strategies for women to use in entering the paid labor force and a process to identify marketable competencies one has acquired. First, strategies are addressed for handling these three components of the change from…

  11. Behavioral Intervention Strategies for Employment Counseling

    ERIC Educational Resources Information Center

    Fuhriman, Addie; Pappas, James P.

    1971-01-01

    Unemployment is seen as unadaptive behavior, and its antecedent conditions are examined. Behavioral counseling tactics of goal setting, contingency management, counterconditioning procedures, and social systems intervention are considered in relation to the employment counselor's repertoire of potential helping responses. A hypothetical case is…

  12. The development of the Swiss Adaptation Strategy

    NASA Astrophysics Data System (ADS)

    Hohmann, R.; Köllner-Heck, P.; Probst, T.

    2010-09-01

    In summer 2009, the Federal Council mandated the Departement of the Environment, Transport, Energy and Communication (DETEC) to develop a Swiss adaptation strategy. This strategy aims to coordinate the efforts of all federal departments involved in adaptation, and to provide them with the necessary basic information. For the development of the Swiss adaptation strategy the following principles are fundamental. (1.) The strategy aims to achieve the overarching objectives of harnessing the opportunities that climate change presents, minimizing the risks of climate change to people and assets, and to increases the adaptive capacity of all resources. (2) The strategy is based on the most recent scientific knowledge about climate change and climate change impacts. (3.) It is based in on a sound and comprehensive analysis of climate change risks. (4.) It includes strategic goals for the sectors that are most vulnerable to climate change, i.e., water management, biodiversity management, agriculture, forestry, natural hazard prevention, health care, energy generation, tourism, land use. (5.) It thoroughly analyzes the interfaces between the sectoral strategies in order solve existing conflicts and profit form existing synergies. The Swiss Adaptation Strategy will be completed and submitted to the Federal Council by the End of 2011.

  13. Dichotomous Search Strategies for Computerized Adaptive Testing.

    ERIC Educational Resources Information Center

    Xiao, Beiling

    Dichotomous search strategies (DSSs) for computerized adaptive testing are similar to golden section search strategies (GSSSs). Each middle point of successive search regions is a testing point. After each item is administered, the subject's obtained score is compared with the expected score at successive testing points. If the subject's obtained…

  14. Multigrid solution strategies for adaptive meshing problems

    NASA Technical Reports Server (NTRS)

    Mavriplis, Dimitri J.

    1995-01-01

    This paper discusses the issues which arise when combining multigrid strategies with adaptive meshing techniques for solving steady-state problems on unstructured meshes. A basic strategy is described, and demonstrated by solving several inviscid and viscous flow cases. Potential inefficiencies in this basic strategy are exposed, and various alternate approaches are discussed, some of which are demonstrated with an example. Although each particular approach exhibits certain advantages, all methods have particular drawbacks, and the formulation of a completely optimal strategy is considered to be an open problem.

  15. Strategies for Computerized Adaptive Grading Testing.

    ERIC Educational Resources Information Center

    Xiao, Beiling

    1999-01-01

    Evaluated three strategies for assigning examinees to grading categories in computerized adaptive testing. The expected a posteriori-based method had more correct classifications in the middle range of grade levels and more errors for the extremes than the golden section search grading test and the Z-score grading test. (SLD)

  16. Marketing strategies nurses can employ to promote health.

    PubMed

    McCormack, D

    1994-01-01

    Marketing strategies are employed to ensure the success of new products, services or programs. Both profit and non-profit organizations have used social marketing strategies to inform, to motivate interest, and to engage the involvement of the consumer. A client-dependent health care system did not find it necessary to market services, but a health care system that encourages clients to choose the most appropriate health promotion service available must market services. Nurses are in the business of promoting the health of clients. Therefore, it is essential that nurses become familiar with, and involved in, the development of marketing plans and strategies. The connection between the four variables of the marketing mix (product, promotion, place, and price) and promoting the health of clients is described. A case example recapitulating the marketing strategies employed to raise public awareness of a self-help group for family caregivers is related, the marketing response is evaluated, and future recommendations are proposed.

  17. Climate change adaptation strategies and mitigation policies

    NASA Astrophysics Data System (ADS)

    García Fernández, Cristina

    2015-04-01

    The pace of climate change and the consequent warming of the Earth's surface is increasing vulnerability and decreasing adaptive capacity. Achieving a successful adaptation depends on the development of technology, institutional organization, financing availability and the exchange of information. Populations living in arid and semi-arid zones, low-lying coastal areas, land with water shortages or at risk of overflow or small islands are particularly vulnerable to climate change. Due to increasing population density in sensitive areas, some regions have become more vulnerable to events such as storms, floods and droughts, like the river basins and coastal plains. Human activities have fragmented and increased the vulnerability of ecosystems, which limit both, their natural adaptation and the effectiveness of the measures adopted. Adaptation means to carry out the necessary modifications for society to adapt to new climatic conditions in order to reduce their vulnerability to climate change. Adaptive capacity is the ability of a system to adjust to climate change (including climate variability and extremes) and to moderate potential damages, to take advantage of opportunities or face the consequences. Adaptation reduces the adverse impacts of climate change and enhance beneficial impacts, but will not prevent substantial cost that are produced by all damages. The performances require adaptation actions. These are defined and implemented at national, regional or local levels since many of the impacts and vulnerabilities depend on the particular economic, geographic and social circumstances of each country or region. We will present some adaptation strategies at national and local level and revise some cases of its implementation in several vulnerable areas. However, adaptation to climate change must be closely related to mitigation policies because the degree of change planned in different climatic variables is a function of the concentration levels that are achieved

  18. Adaptation Strategies for Global Environmental Change

    NASA Astrophysics Data System (ADS)

    Ojima, D. S.; Corell, R.

    2007-12-01

    The global environmental challenges society faces today are unheralded due to the pace at which human activities are affecting the earth system. The rates of energy consumption, nitrogen use and production, and water use increases each year leading to greater global environmental changes affecting warming of the earth system and loss of ecosystem services. The challenge we face today as a society is the manner and speed at which we can adapt to these changes affecting the ecosystem services we depend upon. Innovative strategies are needed to develop the adaptive management tools to integrate the sectors and science necessary to deal with the complexity of effects. Developing strategies to better guide decision making related to climate change trends into changing weather patterns at meaningful temporal and spatial scales are needed, observations and prognostic analyses of climate related triggers of threshold events in ecosystem dynamics, and transfer of knowledge between science, technology, and decision makers. These strategies need to better integrate science (physical, biological, and social knowledge), engineering, policy, and economics interests to create a framework to develop strategies for adaptation and mitigation to global change and to create bridges with institutions and organizations that deal with these issues as a governmental agency or private sector enterprise.

  19. Complex adaptive therapeutic strategy (CATS) for cancer.

    PubMed

    Cho, Yong Woo; Kim, Sang Yoon; Kwon, Ick Chan; Kim, In-San

    2014-02-10

    Tumors begin with a single cell, but as each tumor grows and evolves, it becomes a wide collection of clones that display remarkable heterogeneity in phenotypic features, which has posed a big challenge to current targeted anticancer therapy. Intra- and inter-tumoral heterogeneity is attributable in part to genetic mutations but also to adaptation and evolution of tumors to heterogeneity in tumor microenvironments. If tumors are viewed not only as a disease but also as a complex adaptive system (CAS), tumors should be treated as such and a more systemic approach is needed. Some of many tumors therapeutic strategies are discussed here from a view of a tumor as CAS, which can be collectively called a complex adaptive therapeutic strategy (CATS). The central theme of CATS is based on three intermediate concepts: i) disruption of artifacts, ii) disruption of connections, and iii) reprogramming of cancer-immune dynamics. Each strategy presented here is a piece of the puzzle for CATS. Although each piece by itself may be neither novel nor profound, an assembled puzzle could be a novel and innovative cancer therapeutic strategy.

  20. Canadian Families' Strategies for Employment and Care for Preschool Children

    ERIC Educational Resources Information Center

    Ornstein, Michael; Stalker, Glenn J.

    2013-01-01

    Based on the 2006 Canadian Census "long form" sample of one in every five households, the authors develop a detailed typology of family strategies for employment and the care of preschool children. The analysis is restricted to opposite-sex couples with at least one child under age 6 and no older child or other adult in the household.…

  1. Climate adaptation strategy for natural resources released

    NASA Astrophysics Data System (ADS)

    Showstack, Randy

    2013-04-01

    The National Fish, Wildlife, and Plants Climate Adaptation Strategy, released on 26 March by the Obama administration, calls for a series of measures to help public and private decision makers better address the effects of climate change on living natural resources. The measures include conserving habitat to support healthy fish, wildlife, and plant populations and ecosystem functions; managing species and habitats to protect ecosystem functions and provide sustainable commercial, subsistence, recreational, and cultural use; increasing knowledge and information about effects on and responses of fish, wildlife, and plants; and reducing nonclimate stressors to help fish, wildlife, plants, and ecosystems adapt.

  2. Adaptive Control Strategies for Flexible Robotic Arm

    NASA Technical Reports Server (NTRS)

    Bialasiewicz, Jan T.

    1996-01-01

    The control problem of a flexible robotic arm has been investigated. The control strategies that have been developed have a wide application in approaching the general control problem of flexible space structures. The following control strategies have been developed and evaluated: neural self-tuning control algorithm, neural-network-based fuzzy logic control algorithm, and adaptive pole assignment algorithm. All of the above algorithms have been tested through computer simulation. In addition, the hardware implementation of a computer control system that controls the tip position of a flexible arm clamped on a rigid hub mounted directly on the vertical shaft of a dc motor, has been developed. An adaptive pole assignment algorithm has been applied to suppress vibrations of the described physical model of flexible robotic arm and has been successfully tested using this testbed.

  3. Adaptive Strategies for Materials Design using Uncertainties.

    PubMed

    Balachandran, Prasanna V; Xue, Dezhen; Theiler, James; Hogden, John; Lookman, Turab

    2016-01-21

    We compare several adaptive design strategies using a data set of 223 M2AX family of compounds for which the elastic properties [bulk (B), shear (G), and Young's (E) modulus] have been computed using density functional theory. The design strategies are decomposed into an iterative loop with two main steps: machine learning is used to train a regressor that predicts elastic properties in terms of elementary orbital radii of the individual components of the materials; and a selector uses these predictions and their uncertainties to choose the next material to investigate. The ultimate goal is to obtain a material with desired elastic properties in as few iterations as possible. We examine how the choice of data set size, regressor and selector impact the design. We find that selectors that use information about the prediction uncertainty outperform those that don't. Our work is a step in illustrating how adaptive design tools can guide the search for new materials with desired properties.

  4. What strategies do ulcerative colitis patients employ to facilitate adherence?

    PubMed Central

    Kawakami, Aki; Tanaka, Makoto; Naganuma, Makoto; Maeda, Shin; Kunisaki, Reiko; Yamamoto-Mitani, Noriko

    2017-01-01

    Background Overall, 30%–45% of patients with ulcerative colitis (UC) are non-adherent and have difficulties taking their medications; this non-adherence increases the risk of clinical relapse 1.4- to 5.5-fold. This study aimed to clarify the strategies patients employ to facilitate adherence and determine whether the strategies had an impact on good adherence. Methods This was a cross-sectional survey using a self-administered questionnaire and review of medical records. Patients diagnosed as having UC and attending one of the outpatient clinics of four urban hospitals from June 2009 to December 2012 were enrolled. A questionnaire was developed to identify the strategies patients employ to facilitate adherence and then administered to patients with UC. Adherence to 5-aminosalicylic acid was calculated, and univariate and multiple logistic regression analyses were performed to determine the strategies that were associated with good adherence. Results The final analyses included 671 participants (mean age 40.2 years; 54.3% males). The valid response rate was 96.9%; 186 (27.7%) participants were classified as non-adherent, the mean adherence rate being 86.1% (standard deviation [SD] 17.9). Seven strategies that patients employ to facilitate adherence were identified, the following two being significantly associated with good adherence: “I keep my medicines where I eat meals” and “I keep each day’s medicine in a pill case or something similar to make sure I have taken them”. Conclusion The identified strategies might be used to develop a program to improve medication adherence in patients with UC. PMID:28203059

  5. An adaptive strategy for active debris removal

    NASA Astrophysics Data System (ADS)

    White, Adam E.; Lewis, Hugh G.

    2014-04-01

    Many parameters influence the evolution of the near-Earth debris population, including launch, solar, explosion and mitigation activities, as well as other future uncertainties such as advances in space technology or changes in social and economic drivers that effect the utilisation of space activities. These factors lead to uncertainty in the long-term debris population. This uncertainty makes it difficult to identify potential remediation strategies, involving active debris removal (ADR), that will perform effectively in all possible future cases. Strategies that cannot perform effectively, because of this uncertainty, risk either not achieving their intended purpose, or becoming a hindrance to the efforts of spacecraft manufactures and operators to address the challenges posed by space debris. One method to tackle this uncertainty is to create a strategy that can adapt and respond to the space debris population. This work explores the concept of an adaptive strategy, in terms of the number of objects required to be removed by ADR, to prevent the low Earth orbit (LEO) debris population from growing in size. This was demonstrated by utilising the University of Southampton’s Debris Analysis and Monitoring Architecture to the Geosynchronous Environment (DAMAGE) tool to investigate ADR rates (number of removals per year) that change over time in response to the current space environment, with the requirement of achieving zero growth of the LEO population. DAMAGE was used to generate multiple Monte Carlo projections of the future LEO debris environment. Within each future projection, the debris removal rate was derived at five-year intervals, by a new statistical debris evolutionary model called the Computational Adaptive Strategy to Control Accurately the Debris Environment (CASCADE) model. CASCADE predicted the long-term evolution of the current DAMAGE population with a variety of different ADR rates in order to identify a removal rate that produced a zero net

  6. Adaptive Strategies in the Iterated Exchange Problem

    NASA Astrophysics Data System (ADS)

    Baraov, Arthur

    2011-03-01

    We argue for clear separation of the exchange problem from the exchange paradox to avoid confusion about the subject matter of these two distinct problems. The exchange problem in its current format belongs to the domain of optimal decision making—it doesn't make any sense as a game of competition. But it takes just a tiny modification in the statement of the problem to breathe new life into it and make it a practicable and meaningful game of competition. In this paper, we offer an explanation for paradoxical priors and discuss adaptive strategies for both the house and the player in the restated exchange problem.

  7. Employment of Adaptive Learning Techniques for the Discrimination of Acoustic Emissions.

    DTIC Science & Technology

    1983-11-01

    8D-1Ai38 142 EMPLOYMENT OP ADAPTIVE LEARNING TECHNIQUES FOR THE I DISCRIMINATION OF ACOU..(U) GENERAL ELECTRIC CORPORATE U Ch, RESEARCH AND...OFSTNDRD-96- 1.5%. 111 11 :%____ 111. %I1~.~ 11 1 - 111 -- k. -Jr -. P. -L -. b. EMPLOYMENT OF ADAPTIVE LEARNING TECHNIQUESEli FOR THE DISCRIMINATION OF...8217Include Security Claaaaficatiano Employment of Adaptive * Learning Techniques for the Discrimination Of Acoustic Emissions (Unclassified) 12.’ PE SNAU.R S

  8. Adaptive strategies for materials design using uncertainties

    SciTech Connect

    Balachandran, Prasanna V.; Xue, Dezhen; Theiler, James; Hogden, John; Lookman, Turab

    2016-01-21

    Here, we compare several adaptive design strategies using a data set of 223 M2AX family of compounds for which the elastic properties [bulk (B), shear (G), and Young’s (E) modulus] have been computed using density functional theory. The design strategies are decomposed into an iterative loop with two main steps: machine learning is used to train a regressor that predicts elastic properties in terms of elementary orbital radii of the individual components of the materials; and a selector uses these predictions and their uncertainties to choose the next material to investigate. The ultimate goal is to obtain a material with desired elastic properties in as few iterations as possible. We examine how the choice of data set size, regressor and selector impact the design. We find that selectors that use information about the prediction uncertainty outperform those that don’t. Our work is a step in illustrating how adaptive design tools can guide the search for new materials with desired properties.

  9. Adaptive strategies for materials design using uncertainties

    DOE PAGES

    Balachandran, Prasanna V.; Xue, Dezhen; Theiler, James; ...

    2016-01-21

    Here, we compare several adaptive design strategies using a data set of 223 M2AX family of compounds for which the elastic properties [bulk (B), shear (G), and Young’s (E) modulus] have been computed using density functional theory. The design strategies are decomposed into an iterative loop with two main steps: machine learning is used to train a regressor that predicts elastic properties in terms of elementary orbital radii of the individual components of the materials; and a selector uses these predictions and their uncertainties to choose the next material to investigate. The ultimate goal is to obtain a material withmore » desired elastic properties in as few iterations as possible. We examine how the choice of data set size, regressor and selector impact the design. We find that selectors that use information about the prediction uncertainty outperform those that don’t. Our work is a step in illustrating how adaptive design tools can guide the search for new materials with desired properties.« less

  10. Adaptive Strategies for Materials Design using Uncertainties

    PubMed Central

    Balachandran, Prasanna V.; Xue, Dezhen; Theiler, James; Hogden, John; Lookman, Turab

    2016-01-01

    We compare several adaptive design strategies using a data set of 223 M2AX family of compounds for which the elastic properties [bulk (B), shear (G), and Young’s (E) modulus] have been computed using density functional theory. The design strategies are decomposed into an iterative loop with two main steps: machine learning is used to train a regressor that predicts elastic properties in terms of elementary orbital radii of the individual components of the materials; and a selector uses these predictions and their uncertainties to choose the next material to investigate. The ultimate goal is to obtain a material with desired elastic properties in as few iterations as possible. We examine how the choice of data set size, regressor and selector impact the design. We find that selectors that use information about the prediction uncertainty outperform those that don’t. Our work is a step in illustrating how adaptive design tools can guide the search for new materials with desired properties. PMID:26792532

  11. Biometeorology - a science supporting adaptation strategies

    NASA Astrophysics Data System (ADS)

    Matzarakis, A.; Cegnar, T.

    2010-09-01

    Biometeorology as an interdisciplinary science deals with the interactions between atmospheric processes and living organisms (plants, animals and humans). If and in what way weather and climate affect the well-being of all the living creatures? This is the most important question biometeorology is answering. The International Society of Biometeorology (ISB) has built an international forum for the promotion of interdisciplinary collaboration between meteorologists, health professionals, biologists, climatologists, ecologists and other scientists. The Society acts as a community of scientists with similar interests, and fulfills an important role in providing information, expertise and advice for international organizations requiring this assistance. The ISB represents the most comprehensive organization, which brings together people with expertise in these areas. Another specific aim of the ISB is the stimulation of research. Therefore, groups of members are working on several topics organized in commissions for specific targets. The recent five commissions are working in the several fields including climate change issues. Some of examples will be presented, which have been initiated by the members of the ISB and how they can be included as a solid scientific basis to develop efficient adaptation strategies. One such example is a project combining natural and social sciences (in the fields of cooperation processes, tourism analysis and strategy, weather and climate change analysis, information and communication and knowledge transfer) in a transdisciplinary approach that includes players from tourism policy and business and which focuses on the North Sea Coast and the Black Forest. The project "Climate trends and sustainable development of tourism in coastal and mountain range regions was divided into four phases - diagnosis, assessment, strategy/design of solutions, and evaluation - where scientific subprojects and practical partners meet regularly to discuss the

  12. Growing Your Business by Adapting Employer Child Care Practices

    ERIC Educational Resources Information Center

    Spencer, Becky

    2012-01-01

    As an early childhood professional for 30 years operating both traditional and employer child care programs, the author believes that traditional center owners and operators have an opportunity to grow their business, serve more children and families, and stay relevant for future workforce needs by integrating employer child care practices into…

  13. Bed bugs evolved unique adaptive strategy to resist pyrethroid insecticides.

    PubMed

    Zhu, Fang; Gujar, Hemant; Gordon, Jennifer R; Haynes, Kenneth F; Potter, Michael F; Palli, Subba R

    2013-01-01

    Recent advances in genomic and post-genomic technologies have facilitated a genome-wide analysis of the insecticide resistance-associated genes in insects. Through bed bug, Cimex lectularius transcriptome analysis, we identified 14 molecular markers associated with pyrethroid resistance. Our studies revealed that most of the resistance-associated genes functioning in diverse mechanisms are expressed in the epidermal layer of the integument, which could prevent or slow down the toxin from reaching the target sites on nerve cells, where an additional layer of resistance (kdr) is possible. This strategy evolved in bed bugs is based on their unique morphological, physiological and behavioral characteristics and has not been reported in any other insect species. RNA interference-aided knockdown of resistance associated genes showed the relative contribution of each mechanism towards overall resistance development. Understanding the complexity of adaptive strategies employed by bed bugs will help in designing the most effective and sustainable bed bug control methods.

  14. Bed bugs evolved unique adaptive strategy to resist pyrethroid insecticides

    PubMed Central

    Zhu, Fang; Gujar, Hemant; Gordon, Jennifer R.; Haynes, Kenneth F.; Potter, Michael F.; Palli, Subba R.

    2013-01-01

    Recent advances in genomic and post-genomic technologies have facilitated a genome-wide analysis of the insecticide resistance-associated genes in insects. Through bed bug, Cimex lectularius transcriptome analysis, we identified 14 molecular markers associated with pyrethroid resistance. Our studies revealed that most of the resistance-associated genes functioning in diverse mechanisms are expressed in the epidermal layer of the integument, which could prevent or slow down the toxin from reaching the target sites on nerve cells, where an additional layer of resistance (kdr) is possible. This strategy evolved in bed bugs is based on their unique morphological, physiological and behavioral characteristics and has not been reported in any other insect species. RNA interference-aided knockdown of resistance associated genes showed the relative contribution of each mechanism towards overall resistance development. Understanding the complexity of adaptive strategies employed by bed bugs will help in designing the most effective and sustainable bed bug control methods. PMID:23492626

  15. Adaptive versus nonadaptive strategies for quantum channel discrimination

    SciTech Connect

    Harrow, Aram W.; Hassidim, Avinatan; Leung, Debbie W.; Watrous, John

    2010-03-15

    We provide a simple example that illustrates the advantage of adaptive over nonadaptive strategies for quantum channel discrimination. In particular, we give a pair of entanglement-breaking channels that can be perfectly discriminated by means of an adaptive strategy that requires just two channel evaluations, but for which no nonadaptive strategy can give a perfect discrimination using any finite number of channel evaluations.

  16. The Relations of Employability Skills to Career Adaptability among Technical School Students

    ERIC Educational Resources Information Center

    de Guzman, Allan B.; Choi, Kyoung Ok

    2013-01-01

    This two pronged study reports the initial validation of the psychometric properties and factor structure of the Career Adapt-Abilities Scale (CAAS) in the context of Papua New Guinea (PNG) and the investigation of the relationship between employability skills and career adaptability. Results of the study revealed that CAAS can be a valid and…

  17. Horizontal Path Laser Communications Employing MEMS Adaptive Optics Correction

    SciTech Connect

    Thompson, C A; Wilks, S C; Brase, J M; Young, R A; Johnson, G W; Ruggiero, A J

    2001-09-05

    Horizontal path laser communications are beginning to provide attractive alternatives for high-speed optical communications, In particular, companies are beginning to sell fiberless alternatives for intranet and sporting event video. These applications are primarily aimed at short distance applications (on the order of 1 km pathlength). There exists a potential need to extend this pathlength to distances much greater than a 1km. For cases of long distance optical propagation, atmospheric turbulence will ultimately limit the maximum achievable data rate. In this paper, we propose a method of improved signal quality through the use of adaptive optics. In particular, we show work in progress toward a high-speed, small footprint Adaptive Optics system for horizontal path laser communications. Such a system relies heavily on recent progress in Micro-Electro-Mechanical Systems (MEMS) deformable mirrors as well as improved communication and computational components. In this paper we detail two Adaptive Optics approaches for improved through-put, the first is the compensated receiver (the traditional Adaptive Optics approach), the second is the compensated transmitter/receiver. The second approach allows for correction of the optical wavefront before transmission from the transmitter and prior to detection at the receiver.

  18. Did recent world record marathon runners employ optimal pacing strategies?

    PubMed

    Angus, Simon D

    2014-01-01

    We apply statistical analysis of high frequency (1 km) split data for the most recent two world-record marathon runs: Run 1 (2:03:59, 28 September 2008) and Run 2 (2:03:38, 25 September 2011). Based on studies in the endurance cycling literature, we develop two principles to approximate 'optimal' pacing in the field marathon. By utilising GPS and weather data, we test, and then de-trend, for each athlete's field response to gradient and headwind on course, recovering standardised proxies for power-based pacing traces. The resultant traces were analysed to ascertain if either runner followed optimal pacing principles; and characterise any deviations from optimality. Whereas gradient was insignificant, headwind was a significant factor in running speed variability for both runners, with Runner 2 targeting the (optimal) parallel variation principle, whilst Runner 1 did not. After adjusting for these responses, neither runner followed the (optimal) 'even' power pacing principle, with Runner 2's macro-pacing strategy fitting a sinusoidal oscillator with exponentially expanding envelope whilst Runner 1 followed a U-shaped, quadratic form. The study suggests that: (a) better pacing strategy could provide elite marathon runners with an economical pathway to significant performance improvements at world-record level; and (b) the data and analysis herein is consistent with a complex-adaptive model of power regulation.

  19. Understanding cybercrime perpetrators and the strategies they employ in Nigeria.

    PubMed

    Aransiola, Joshua Oyeniyi; Asindemade, Suraj Olalekan

    2011-12-01

    A lot has been written on cybercrime and its prevention, but the problem has proved particularly resilient to remedial action. Desperate and vulnerable individuals in every continent continue to fall into its trap. Despite this, there is dearth of descriptive study that attempts to unravel the strategies employed by the perpetrators in Nigeria, as an important precondition for workable and reliable policy direction to address the problem. This article has filled this gap by using data from 40 cybercrime perpetrators selected with snowballing technique. The findings revealed that most of the cybercrime perpetrators in Nigeria are between the age of 22 and 29 years who were undergraduates and have distinctive lifestyles from other youths. Their strategies include collaboration with security agents and bank officials, local and international networking, and the use of voodoo that is, traditional supernatural power. It was clear that most perpetrators of cybercrime were involved in on-line dating and buying and selling with fake identity among others. The article discussed the need for reorientation of Nigerian youths in higher institutions, and various methods as guiding principles for potential victims. It recommended a complete reorganization of the Nigerian Police Force and Economic and Financial Crime Commission, as some of the officers in the institutions aid and abet cybercrime. It finally suggested a review of the Nigerian law guiding the operations of banking, poster agencies, and various speed post services in the country, as these are necessary preconditions to effectively combat the problem.

  20. A holistic strategy for adaptive land management

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Adaptive management is widely applied to natural resources management. Adaptive management can be generally defined as an iterative decision-making process that incorporates formulation of management objectives, actions designed to address these objectives, monitoring of results, and repeated adapta...

  1. Communication strategies employed by rare disease patient organizations in Spain.

    PubMed

    Castillo-Esparcia, Antonio; López-Villafranca, Paloma

    2016-08-01

    The current study focuses on communication strategies employed by rare disease patient organizations. The aims of these organizations are: educate and inform the public about rare diseases, raise awareness of the problems related to rare diseases, and achieve social legitimacy in order give visibility to their demands. We analyzed the portrayal of rare disease and patient organizations by Spain's major media organizations in terms of circulation and viewership - the press (El País, El Mundo, La Vanguardia,ABC and El Periódico), radio (CadenaSer, Onda Cero, Cope and RNE), and television (Telecinco, Antena 3, La 1, La Sexta, Cuatro) -between 2012 and 2014.We then carried out a descriptive analysis of communication activities performed via the World Wide Web and social networks by 143 national organizations. Finally, we conducted a telephone questionnaire of a representative sample of 90 organizations in order to explore the association between media presence and funding and public image. The triangulation of quantitative and qualitative methods allowed us to meet the study's objectives. Increased visibility of the organizations afforded by an increase in the coverage of the topic by the medialed to an increase in membership - but not in donations - and increased awareness of these diseases.

  2. Adapting MCH strategies for the nineties.

    PubMed

    Abel, R

    1994-01-01

    Brief overview was given for strategies in maternal and child health (MCH) in India that were used in the 1980s and adapted for the 1990s in the following areas: perinatal outcomes, empowerment of women, immunization, oral rehydration, adolescent girls, anthropometric measurement, health education, management, and coordination with nongovernmental organizations (NGOs). In order to assure a healthy baby weighing 2.5 kg, monitoring of maternal health is occurring. Iron and folic acid and tetanus toxoid vaccine are provided to pregnant mothers, and fetal growth is monitored. Training of traditional birth attendants and multipurpose health workers will contribute to clean deliveries and referral of complicated pregnancies. During the 1990s, women's health in addition to maternal health has received attention. The empowerment of women to care for themselves, to learn how to mix oral rehydration packets (ORS) at home, and to receive the knowledge and skills were deemed more important than the 1980s focus on the delivery system and inputs of MCH. An excellent cold chain for delivery of vaccines has been put in place, which provides the vehicle for the 1990s to maintain high vaccine coverage. The emphasis on oral rehydration in the 1990s will be on teaching mothers about the importance of ORS treatment of diarrhea. During the 1990s, educating the adolescent girl before she becomes married and pregnant will be the focus. Greater emphasis will be placed on stunting or height for age measurements, as a measure of long term nutritional change; age weight for height for measurement of wasting; and maternal nutritional monitoring of arm circumference. Sustained health education, more media exposure to disease conditions and treatment, and social marketing in health will be better coordinated and more cost effective. Accountability for manpower, materials, and money will be in place within management. Management will focus on motivation and training, and other, newer management

  3. A holistic strategy for adaptive land management

    USGS Publications Warehouse

    Herrick, Jeffrey E.; Duniway, Michael C.; Pyke, David A.; Bestelmeyer, Brandon T.; Wills, Skye A.; Brown, Joel R.; Karl, Jason W.; Havstad, Kris M.

    2012-01-01

    Adaptive management is widely applied to natural resources management (Holling 1973; Walters and Holling 1990). Adaptive management can be generally defined as an iterative decision-making process that incorporates formulation of management objectives, actions designed to address these objectives, monitoring of results, and repeated adaptation of management until desired results are achieved (Brown and MacLeod 1996; Savory and Butterfield 1999). However, adaptive management is often criticized because very few projects ever complete more than one cycle, resulting in little adaptation and little knowledge gain (Lee 1999; Walters 2007). One significant criticism is that adaptive management is often used as a justification for undertaking actions with uncertain outcomes or as a surrogate for the development of specific, measurable indicators and monitoring programs (Lee 1999; Ruhl 2007).

  4. A Reform Strategy for Education: Employer-Sponsored Teacher Internships.

    ERIC Educational Resources Information Center

    Gold, Gerard G.

    1987-01-01

    Summer teacher internships that are employer-sponsored benefit the teachers, the employers, and the students. Most of the programs have concentrated on improving science and mathematics teaching. Educating employers and school districts about the benefits of participating in these programs is a complex and difficult task. (MD)

  5. Employability during Unemployment: Adaptability, Career Identity and Human and Social Capital

    ERIC Educational Resources Information Center

    McArdle, Sarah; Waters, Lea; Briscoe, Jon P.; Hall, Douglas T.

    2007-01-01

    Recently, Fugate et al. [Fugate, M., Kinicki, A. J., & Ashforth, B. E. (2004). Employability: A psycho-social construct, its dimensions, and applications. "Journal of Vocational Behavior, 65"(1), 14] defined employability as a psycho-social construct comprised of three dimensions: (i) adaptability; (ii) career identity; and (iii)…

  6. Molecular Adaptation Mechanisms Employed by Ethanologenic Bacteria in Response to Lignocellulose-derived Inhibitory Compounds

    PubMed Central

    Ibraheem, Omodele; Ndimba, Bongani K.

    2013-01-01

    Current international interest in finding alternative sources of energy to the diminishing supplies of fossil fuels has encouraged research efforts in improving biofuel production technologies. In countries which lack sufficient food, the use of sustainable lignocellulosic feedstocks, for the production of bioethanol, is an attractive option. In the pre-treatment of lignocellulosic feedstocks for ethanol production, various chemicals and/or enzymatic processes are employed. These methods generally result in a range of fermentable sugars, which are subjected to microbial fermentation and distillation to produce bioethanol. However, these methods also produce compounds that are inhibitory to the microbial fermentation process. These compounds include products of sugar dehydration and lignin depolymerisation, such as organic acids, derivatised furaldehydes and phenolic acids. These compounds are known to have a severe negative impact on the ethanologenic microorganisms involved in the fermentation process by compromising the integrity of their cell membranes, inhibiting essential enzymes and negatively interact with their DNA/RNA. It is therefore important to understand the molecular mechanisms of these inhibitions, and the mechanisms by which these microorganisms show increased adaptation to such inhibitors. Presented here is a concise overview of the molecular adaptation mechanisms of ethanologenic bacteria in response to lignocellulose-derived inhibitory compounds. These include general stress response and tolerance mechanisms, which are typically those that maintain intracellular pH homeostasis and cell membrane integrity, activation/regulation of global stress responses and inhibitor substrate-specific degradation pathways. We anticipate that understanding these adaptation responses will be essential in the design of 'intelligent' metabolic engineering strategies for the generation of hyper-tolerant fermentation bacteria strains. PMID:23847442

  7. Molecular adaptation mechanisms employed by ethanologenic bacteria in response to lignocellulose-derived inhibitory compounds.

    PubMed

    Ibraheem, Omodele; Ndimba, Bongani K

    2013-01-01

    Current international interest in finding alternative sources of energy to the diminishing supplies of fossil fuels has encouraged research efforts in improving biofuel production technologies. In countries which lack sufficient food, the use of sustainable lignocellulosic feedstocks, for the production of bioethanol, is an attractive option. In the pre-treatment of lignocellulosic feedstocks for ethanol production, various chemicals and/or enzymatic processes are employed. These methods generally result in a range of fermentable sugars, which are subjected to microbial fermentation and distillation to produce bioethanol. However, these methods also produce compounds that are inhibitory to the microbial fermentation process. These compounds include products of sugar dehydration and lignin depolymerisation, such as organic acids, derivatised furaldehydes and phenolic acids. These compounds are known to have a severe negative impact on the ethanologenic microorganisms involved in the fermentation process by compromising the integrity of their cell membranes, inhibiting essential enzymes and negatively interact with their DNA/RNA. It is therefore important to understand the molecular mechanisms of these inhibitions, and the mechanisms by which these microorganisms show increased adaptation to such inhibitors. Presented here is a concise overview of the molecular adaptation mechanisms of ethanologenic bacteria in response to lignocellulose-derived inhibitory compounds. These include general stress response and tolerance mechanisms, which are typically those that maintain intracellular pH homeostasis and cell membrane integrity, activation/regulation of global stress responses and inhibitor substrate-specific degradation pathways. We anticipate that understanding these adaptation responses will be essential in the design of 'intelligent' metabolic engineering strategies for the generation of hyper-tolerant fermentation bacteria strains.

  8. Global Isotope Metabolomics Reveals Adaptive Strategies for Nitrogen Assimilation.

    PubMed

    Kurczy, Michael E; Forsberg, Erica M; Thorgersen, Michael P; Poole, Farris L; Benton, H Paul; Ivanisevic, Julijana; Tran, Minerva L; Wall, Judy D; Elias, Dwayne A; Adams, Michael W W; Siuzdak, Gary

    2016-06-17

    Nitrogen cycling is a microbial metabolic process essential for global ecological/agricultural balance. To investigate the link between the well-established ammonium and the alternative nitrate assimilation metabolic pathways, global isotope metabolomics was employed to examine three nitrate reducing bacteria using (15)NO3 as a nitrogen source. In contrast to a control (Pseudomonas stutzeri RCH2), the results show that two of the isolates from Oak Ridge, Tennessee (Pseudomonas N2A2 and N2E2) utilize nitrate and ammonia for assimilation concurrently with differential labeling observed across multiple classes of metabolites including amino acids and nucleotides. The data reveal that the N2A2 and N2E2 strains conserve nitrogen-containing metabolites, indicating that the nitrate assimilation pathway is a conservation mechanism for the assimilation of nitrogen. Co-utilization of nitrate and ammonia is likely an adaption to manage higher levels of nitrite since the denitrification pathways utilized by the N2A2 and N2E2 strains from the Oak Ridge site are predisposed to the accumulation of the toxic nitrite. The use of global isotope metabolomics allowed for this adaptive strategy to be investigated, which would otherwise not have been possible to decipher.

  9. Global isotope metabolomics reveals adaptive strategies for nitrogen assimilation

    SciTech Connect

    Kurczy, Michael E.; Forsberg, Erica M.; Thorgersen, Michael P.; Poole, Farris L.; Benton, H. Paul; Ivanisevic, Julijana; Tran, Minerva L.; Wall, Judy D.; Elias, Dwayne A.; Adams, Michael W. W.; Siuzdak, Gary

    2016-04-05

    Nitrogen cycling is a microbial metabolic process essential for global ecological/agricultural balance. To investigate the link between the well-established ammonium and the alternative nitrate assimilation metabolic pathways, global isotope metabolomics was employed to examine three nitrate reducing bacteria using 15NO3 as a nitrogen source. In contrast to a control (Pseudomonas stutzeri RCH2), the results show that two of the isolates from Oak Ridge, Tennessee (Pseudomonas N2A2 and N2E2) utilize nitrate and ammonia for assimilation concurrently with differential labeling observed across multiple classes of metabolites including amino acids and nucleotides. The data reveal that the N2A2 and N2E2 strains conserve nitrogen-containing metabolites, indicating that the nitrate assimilation pathway is a conservation mechanism for the assimilation of nitrogen. Co-utilization of nitrate and ammonia is likely an adaption to manage higher levels of nitrite since the denitrification pathways utilized by the N2A2 and N2E2 strains from the Oak Ridge site are predisposed to the accumulation of the toxic nitrite. In conclusion, the use of global isotope metabolomics allowed for this adaptive strategy to be investigated, which would otherwise not have been possible to decipher.

  10. Global isotope metabolomics reveals adaptive strategies for nitrogen assimilation

    DOE PAGES

    Kurczy, Michael E.; Forsberg, Erica M.; Thorgersen, Michael P.; ...

    2016-04-05

    Nitrogen cycling is a microbial metabolic process essential for global ecological/agricultural balance. To investigate the link between the well-established ammonium and the alternative nitrate assimilation metabolic pathways, global isotope metabolomics was employed to examine three nitrate reducing bacteria using 15NO3 as a nitrogen source. In contrast to a control (Pseudomonas stutzeri RCH2), the results show that two of the isolates from Oak Ridge, Tennessee (Pseudomonas N2A2 and N2E2) utilize nitrate and ammonia for assimilation concurrently with differential labeling observed across multiple classes of metabolites including amino acids and nucleotides. The data reveal that the N2A2 and N2E2 strains conserve nitrogen-containingmore » metabolites, indicating that the nitrate assimilation pathway is a conservation mechanism for the assimilation of nitrogen. Co-utilization of nitrate and ammonia is likely an adaption to manage higher levels of nitrite since the denitrification pathways utilized by the N2A2 and N2E2 strains from the Oak Ridge site are predisposed to the accumulation of the toxic nitrite. In conclusion, the use of global isotope metabolomics allowed for this adaptive strategy to be investigated, which would otherwise not have been possible to decipher.« less

  11. Adaptation and optimal chemotactic strategy for {ital E. coli}

    SciTech Connect

    Strong, S.P.; Bialek, William; Koberle, R. Freedman, B.

    1998-04-01

    Extending the classic works of Berg and Purcell on the biophysics of bacterial chemotaxis, we find the optimal chemotactic strategy for the peritrichous bacterium {ital E. coli} in the high and low signal to noise ratio limits. The optimal strategy depends on properties of the environment and properties of the individual bacterium, and is therefore highly adaptive. We review experiments relevant to testing both the form of the proposed strategy and its adaptability, and propose extensions of them which could test the limits of the adaptability in this simplest sensory processing system. {copyright} {ital 1998} {ital The American Physical Society}

  12. Ethnic enclaves and middleman minorities: alternative strategies of immigrant adaptation?

    PubMed

    Cobas, J A

    1987-04-01

    This article examines 2 modes or strategies of immigrant adaptation: middleman minorities and ethnic enclaves. Although they have been discussed as if they were disjointed and mutually exclusive, the authors challenge this view. Middleman minorities 1) tend to be self-employed or to work for a coethnic, 2) are usually concentrated in small business, 3) tend to rely on the in-group for resources, and 4) fill a "status gap" in the receiving society. Ethnic enclaves depend on 3 features: 1) recent coethnic arrivals spend a tour of duty at the worst jobs, 2) coethnics provide ethnic entrepreneurs with consumer markets, 3) ethnic businesses rely on each other to supply their operating needs. Ethnic enclaves are concentrated and spatially identifiable. For this study, the authors collected data in a survey of the Cuban exile community of San Juan, Puerto Rico. The sample selection procedure yielded a total of 261 individuals, 220 of whom were interviewed. 10 predictions found in the middleman minority and ethnic enclave perspectives were checked against the researchers' data. 4 of these predictions are hld in common by both approaches: 1) eomployment in an ethnic enterprise increases subsequent chances of self-employment, 2) ethnic firms rely on the in-group for business resources, 3) coethnic workers represent an asset to the ethnic entrepreneur in that they occupy important positions requiring the employer's trust, and 4) there is business competition between locals and minority members. As predicted by the middleman strategy, Cuban businesses in Puerto Rico tend not to be immediately productive and there is no evidence of spatial concentration of these businesses. However, fitting the enclave approach, these firms do not dominate certain business lines, Cuban entrepreneurs do not appear to be sojourners, and they tend to have business backgrounds. The middleman perspective is supported in that some elements of the local elite favor Cuban exiles. Thus, there is no

  13. Adaptive strategies for cumulative cultural learning.

    PubMed

    Ehn, Micael; Laland, Kevin

    2012-05-21

    The demographic and ecological success of our species is frequently attributed to our capacity for cumulative culture. However, it is not yet known how humans combine social and asocial learning to generate effective strategies for learning in a cumulative cultural context. Here we explore how cumulative culture influences the relative merits of various pure and conditional learning strategies, including pure asocial and social learning, critical social learning, conditional social learning and individual refiner strategies. We replicate the Rogers' paradox in the cumulative setting. However, our analysis suggests that strategies that resolved Rogers' paradox in a non-cumulative setting may not necessarily evolve in a cumulative setting, thus different strategies will optimize cumulative and non-cumulative cultural learning.

  14. Alcohol and Other Drug Resistance Strategies Employed by Rural Adolescents

    PubMed Central

    Pettigrew, Jonathan; Miller-Day, Michelle; Krieger, Janice; Hecht, Michael L.

    2011-01-01

    This study seeks to identify how rural adolescents make health decisions and utilize communication strategies to resist influence attempts in offers of alcohol, tobacco, and other drugs (ATOD). Semi-structured interviews were conducted with 113 adolescents from rural school districts to solicit information on ATOD norms, past ATOD experiences, and substance offer-response episodes. Rural youths’ resistance strategies were similar to previous findings with urban adolescents – refuse, explain, avoid, and leave (the REAL typology) – while unique features of these strategies were identified including the importance of personal narratives, the articulation of a non-user identity, and being “accountable” to self and others. PMID:21552345

  15. The Contextual Adaptation of English Teachers' Questioning Strategies

    ERIC Educational Resources Information Center

    Xi, Hong-mei; Li, Wang-zi; Lei, Ping

    2010-01-01

    In order to guarantee an interactive classroom atmosphere, English teachers pay much attention to the questioning strategies when they use question-answer teaching method. This paper makes a comprehensive analysis on English teachers' questioning strategies from the perspective of adaptation theory. It shows that the utilization of teachers'…

  16. Adaptive finite element strategies for shell structures

    NASA Technical Reports Server (NTRS)

    Stanley, G.; Levit, I.; Stehlin, B.; Hurlbut, B.

    1992-01-01

    The present paper extends existing finite element adaptive refinement (AR) techniques to shell structures, which have heretofore been neglected in the AR literature. Specific challenges in applying AR to shell structures include: (1) physical discontinuities (e.g., stiffener intersections); (2) boundary layers; (3) sensitivity to geometric imperfections; (4) the sensitivity of most shell elements to mesh distortion, constraint definition and/or thinness; and (5) intrinsic geometric nonlinearity. All of these challenges but (5) are addressed here.

  17. Exposure to stressful environments - Strategy of adaptive responses

    NASA Technical Reports Server (NTRS)

    Farhi, Leon E.

    1991-01-01

    Stresses such as hypoxia, water lack, and heat exposure can produce strains in more than a single organ system, in turn stimulating the body to adapt in multiple ways. Nevertheless, a general strategy of the various adaptive responses emerges when the challenges are divided into three groups: (1) conditions that affect the supply of essential molecules, (2) stresses that prevent the body from regulating properly the output of waste products such as CO2 and heat, and (3) environments that disrupt body transport systems. Problems may arise when there is a conflict between two stresses requiring conflicting adaptive changes. An alternative to adaptation, creation of microenvironment, is often favored by the animal.

  18. Strategies for Seeking Employment in the Small College.

    ERIC Educational Resources Information Center

    Madsen, Sandra

    Since American colleges and universities will need to hire about 500,000 faculty members in the next 25 years, it is important that speech communication graduate schools and current graduate students who will be in that labor pool think about the professional needs of small schools as potential employers of speech faculty. The academic background…

  19. Career Adapt-Abilities Scale--Portugal Form: Psychometric Properties and Relationships to Employment Status

    ERIC Educational Resources Information Center

    Duarte, M. Eduarda; Soares, M. C.; Fraga, S.; Rafael, M.; Lima, M. R.; Paredes, I.; Agostinho, R.; Djalo, A.

    2012-01-01

    The Career-Adaptabilities Scale (CAAS)--Portugal Form consists of four scales, each with seven items, which measure concern, control, curiosity, and confidence as psychosocial resources for managing occupational transitions, developmental tasks, and work traumas. Internal consistency estimates for the subscale and total scores ranged from good to…

  20. Biofilms: strategies for metal corrosion inhibition employing microorganisms.

    PubMed

    Zuo, Rongjun

    2007-10-01

    Corrosion causes dramatic economic loss. Currently widely used corrosion control strategies have disadvantages of being expensive, subject to environmental restrictions, and sometimes inefficient. Studies show that microbial corrosion inhibition is actually a common phenomenon. The present review summarizes recent progress in this novel strategy: corrosion control using beneficial bacteria biofilms. The possible mechanisms may involve: (1) removal of corrosive agents (such as oxygen) by bacterial physiological activities (e.g., aerobic respiration), (2) growth inhibition of corrosion-causing bacteria by antimicrobials generated within biofilms [e.g., sulfate-reducing bacteria (SRB) corrosion inhibition by gramicidin S-producing Bacillus brevis biofilm], (3) generation of protective layer by biofilms (e.g., Bacillus licheniformis biofilm produces on aluminum surface a sticky protective layer of gamma-polyglutamate). Successful utilization of this novel strategy relies on advances in study at the interface of corrosion engineering and biofilm biology.

  1. Focus on climate projections for adaptation strategies

    NASA Astrophysics Data System (ADS)

    Feijt, Arnout; Appenzeller, Christof; Siegmund, Peter; von Storch, Hans

    2016-01-01

    Most papers in this focus issue on ‘climate and climate impact projections for adaptation strategies’ are solicited by the guest editorial team and originate from a cluster of projects that were initiated 5 years ago. These projects aimed to provide climate change and climate change adaptation information for a wide range of societal areas for the lower parts of the deltas of the Rhine and Meuse rivers, and particularly for the Netherlands. The papers give an overview of our experiences, methods, approaches, results and surprises in the process to developing scientifically underpinned climate products and services for various clients. Although the literature on interactions between society and climate science has grown over the past decade both with respect to policy-science framing in post-normal science (Storch et al 2011 J. Environ. Law Policy 1 1-15, van der Sluijs 2012 Nature and Culture 7 174-195), user-science framing (Berkhout et al 2014 Regional Environ. Change 14 879-93) and joint knowledge production (Hegger et al 2014 Regional Environ. Change 14 1049-62), there is still a lot to gain. With this focus issue we want to contribute to best practices in this quickly moving field between science and society.

  2. Alcohol and Other Drug Resistance Strategies Employed by Rural Adolescents

    ERIC Educational Resources Information Center

    Pettigrew, Jonathan; Miller-Day, Michelle; Krieger, Janice; Hecht, Michael L.

    2011-01-01

    This study seeks to identify how rural adolescents make health decisions and utilize communication strategies to resist influence attempts in offers of alcohol, tobacco, and other drugs (ATOD). Semi-structured interviews were conducted with 113 adolescents from rural school districts to solicit information on ATOD norms, past ATOD experiences, and…

  3. Adaptive control strategies for flexible robotic arm

    NASA Technical Reports Server (NTRS)

    Bialasiewicz, Jan T.

    1993-01-01

    The motivation of this research came about when a neural network direct adaptive control scheme was applied to control the tip position of a flexible robotic arm. Satisfactory control performance was not attainable due to the inherent non-minimum phase characteristics of the flexible robotic arm tip. Most of the existing neural network control algorithms are based on the direct method and exhibit very high sensitivity if not unstable closed-loop behavior. Therefore a neural self-tuning control (NSTC) algorithm is developed and applied to this problem and showed promising results. Simulation results of the NSTC scheme and the conventional self-tuning (STR) control scheme are used to examine performance factors such as control tracking mean square error, estimation mean square error, transient response, and steady state response.

  4. Parallel Programming Strategies for Irregular Adaptive Applications

    NASA Technical Reports Server (NTRS)

    Biswas, Rupak; Biegel, Bryan (Technical Monitor)

    2001-01-01

    Achieving scalable performance for dynamic irregular applications is eminently challenging. Traditional message-passing approaches have been making steady progress towards this goal; however, they suffer from complex implementation requirements. The use of a global address space greatly simplifies the programming task, but can degrade the performance for such computations. In this work, we examine two typical irregular adaptive applications, Dynamic Remeshing and N-Body, under competing programming methodologies and across various parallel architectures. The Dynamic Remeshing application simulates flow over an airfoil, and refines localized regions of the underlying unstructured mesh. The N-Body experiment models two neighboring Plummer galaxies that are about to undergo a merger. Both problems demonstrate dramatic changes in processor workloads and interprocessor communication with time; thus, dynamic load balancing is a required component.

  5. Quantitative Analysis of the Adapted Physical Education Employment Market in Higher Education

    ERIC Educational Resources Information Center

    Zhang, Jiabei

    2010-01-01

    The purpose of this study was to analyze the employment market of adapted physical education (APE) careers in higher education since 1975 to see if the increase of this market has continued since 1998. Based on the data collected from the "Chronicle of Higher Education", a total of 887 APE job openings have been posted since 1975,…

  6. Adaptive Strategy Selection in Decision Making.

    DTIC Science & Technology

    1986-07-31

    s__uc _N__SSEFORE COMLZTM[G FORM . REPORT NUMBER ’ 2. GOVT ACCESSION NO. I RECIP ENT* S CATALOG NUMUER 86-1 V4L_ 𔃾 6 4. TITLE (and Subltl)e. S . TYPE OF...Controlling Office) IS. SECURITY CLASS. (of thle eporl) Unclassified Ia. DECLASSIFICATION/DOWNGRADING S . : SCHEDULE * -F.. I. DISTRIBUTION STATEMENT (ofhis...EDITION OF i NOV 65 IS OBSOLETE S /N 0102- LF- 014. 6601 SECURITY CLASSIFICATION OF THIS PAGE (Mhen bets fntard) efficient strategies for a given

  7. Quorum quenching is an antivirulence strategy employed by endophytic bacteria.

    PubMed

    Kusari, Parijat; Kusari, Souvik; Lamshöft, Marc; Sezgin, Selahaddin; Spiteller, Michael; Kayser, Oliver

    2014-08-01

    Bacteria predominantly use quorum sensing to regulate a plethora of physiological activities such as cell-cell crosstalk, mutualism, virulence, competence, biofilm formation, and antibiotic resistance. In this study, we investigated how certain potent endophytic bacteria harbored in Cannabis sativa L. plants use quorum quenching as an antivirulence strategy to disrupt the cell-to-cell quorum sensing signals in the biosensor strain, Chromobacterium violaceum. We used a combination of high-performance liquid chromatography high-resolution mass spectrometry (HPLC-ESI-HRMS(n)) and matrix-assisted laser desorption ionization imaging high-resolution mass spectrometry (MALDI-imaging-HRMS) to first quantify and visualize the spatial distribution of the quorum sensing molecules in the biosensor strain, C. violaceum. We then showed, both quantitatively and visually in high spatial resolution, how selected endophytic bacteria of C. sativa can selectively and differentially quench the quorum sensing molecules of C. violaceum. This study provides fundamental insights into the antivirulence strategies used by endophytes in order to survive in their ecological niches. Such defense mechanisms are evolved in order to thwart the plethora of pathogens invading associated host plants in a manner that prevents the pathogens from developing resistance against the plant/endophyte bioactive secondary metabolites. This work also provides evidence towards utilizing endophytes as tools for biological control of bacterial phytopathogens. In continuation, such insights would even afford new concepts and strategies in the future for combating drug resistant bacteria by quorum-inhibiting clinical therapies.

  8. Strategies for adapting to high rates of employee turnover.

    PubMed

    Mowday, R T

    1984-01-01

    For many organizations facing high rates of employee turnover, strategies for increasing employee retention may not be practical because employees leave for reasons beyond the control of management or the costs of reducing turnover exceed the benefits to be derived. In this situation managers need to consider strategies that can minimize or buffer the organization from the negative consequences that often follow from turnover. Strategies organizations can use to adapt to uncontrollably high employee turnover rates are presented in this article. In addition, suggestions are made for how managers should make choices among the alternative strategies.

  9. Employed parents' satisfaction with food-choice coping strategies. Influence of gender and structure.

    PubMed

    Blake, Christine E; Devine, Carol M; Wethington, Elaine; Jastran, Margaret; Farrell, Tracy J; Bisogni, Carole A

    2009-06-01

    This study aimed to understand parents' evaluations of the way they integrated work-family demands to manage food and eating. Employed, low/moderate-income, urban, U.S., Black, White, and Latino mothers (35) and fathers (34) participated in qualitative interviews exploring work and family conditions and spillover, food roles, and food-choice coping and family-adaptive strategies. Parents expressed a range of evaluations from overall satisfaction to overall dissatisfaction as well as dissatisfaction limited to work, family life, or daily schedule. Evaluation criteria differed by gender. Mothers evaluated satisfaction on their ability to balance work and family demands through flexible home and work conditions, while striving to provide healthy meals for their families. Fathers evaluated satisfaction on their ability to achieve schedule stability and participate in family meals, while meeting expectations to contribute to food preparation. Household, and especially work structural conditions, often served as sizeable barriers to parents fulfilling valued family food roles. These relationships highlight the critical need to consider the intersecting influences of gender and social structure as influences on adults' food choices and dietary intake and to address the challenges of work and family integration among low income employed parents as a way to promote family nutrition in a vulnerable population.

  10. Adaptive Through-Thickness Integration Strategy for Shell Elements

    NASA Astrophysics Data System (ADS)

    Burchitz, I. A.; Meinders, T.; Huétink, J.

    2007-05-01

    Reliable numerical prediction of springback in sheet metal forming is essential for the automotive industry. There are numerous factors that influence the accuracy of springback prediction by using the finite element method. One of the reasons is the through-thickness numerical integration of shell elements. It is known that even for simple problems the traditional integration schemes may require up to 50 integration points to achieve a high accuracy of springback analysis. An adaptive through-thickness integration strategy can be a good alternative. The strategy defines abscissas and weights depending on the integrand's properties and, thus, can adapt itself to improve the accuracy of integration. A concept of the adaptive through-thickness integration strategy for shell elements is presented. It is tested using a simple problem of bending of a beam under tension. Results show that for a similar set of material and process parameters the adaptive Simpson's rule with 7 integration points performs better than the traditional trapezoidal rule with 50 points. The adaptive through-thickness integration strategy for shell elements can improve the accuracy of springback prediction at minimal costs.

  11. Stepping strategies for regulating gait adaptability and stability.

    PubMed

    Hak, Laura; Houdijk, Han; Steenbrink, Frans; Mert, Agali; van der Wurff, Peter; Beek, Peter J; van Dieën, Jaap H

    2013-03-15

    Besides a stable gait pattern, gait in daily life requires the capability to adapt this pattern in response to environmental conditions. The purpose of this study was to elucidate the anticipatory strategies used by able-bodied people to attain an adaptive gait pattern, and how these strategies interact with strategies used to maintain gait stability. Ten healthy subjects walked in a Computer Assisted Rehabilitation ENvironment (CAREN). To provoke an adaptive gait pattern, subjects had to hit virtual targets, with markers guided by their knees, while walking on a self-paced treadmill. The effects of walking with and without this task on walking speed, step length, step frequency, step width and the margins of stability (MoS) were assessed. Furthermore, these trials were performed with and without additional continuous ML platform translations. When an adaptive gait pattern was required, subjects decreased step length (p<0.01), tended to increase step width (p=0.074), and decreased walking speed while maintaining similar step frequency compared to unconstrained walking. These adaptations resulted in the preservation of equal MoS between trials, despite the disturbing influence of the gait adaptability task. When the gait adaptability task was combined with the balance perturbation subjects further decreased step length, as evidenced by a significant interaction between both manipulations (p=0.012). In conclusion, able-bodied people reduce step length and increase step width during walking conditions requiring a high level of both stability and adaptability. Although an increase in step frequency has previously been found to enhance stability, a faster movement, which would coincide with a higher step frequency, hampers accuracy and may consequently limit gait adaptability.

  12. A flicker reduction control strategy using an adaptive var compensator

    SciTech Connect

    Jatskevich, J.; Wasynczuk, O.; Conrad, L.

    1999-11-01

    A detailed computer model of a power network with loads, resistance welders and an Adaptive Var Compensator (AVC) has been developed and used to determine the effectiveness of the AVC on the reduction of observable flicker at neighboring loads. Flicker severity is determined using the UIE/IEC flickermeter methodology. Different control strategies for the AVC are considered and compared with respect to flicker reduction. A new flicker adaptive control (FAC) strategy is proposed that can be used for both power factor correction and flicker reduction. The measurement technique used in the FAC is shown to be accurate even in presence of significant harmonic distortion.

  13. Adaptive mesh strategies for the spectral element method

    NASA Technical Reports Server (NTRS)

    Mavriplis, Catherine

    1992-01-01

    An adaptive spectral method was developed for the efficient solution of time dependent partial differential equations. Adaptive mesh strategies that include resolution refinement and coarsening by three different methods are illustrated on solutions to the 1-D viscous Burger equation and the 2-D Navier-Stokes equations for driven flow in a cavity. Sharp gradients, singularities, and regions of poor resolution are resolved optimally as they develop in time using error estimators which indicate the choice of refinement to be used. The adaptive formulation presents significant increases in efficiency, flexibility, and general capabilities for high order spectral methods.

  14. Integrated testing strategies for toxicity employing new and existing technologies.

    PubMed

    Combes, Robert D; Balls, Michael

    2011-07-01

    We have developed individual, integrated testing strategies (ITS) for predicting the toxicity of general chemicals, cosmetics, pharmaceuticals, inhaled chemicals, and nanoparticles. These ITS are based on published schemes developed previously for the risk assessment of chemicals to fulfil the requirements of REACH, which have been updated to take account of the latest developments in advanced in chemico modelling and in vitro technologies. In addition, we propose an ITS for neurotoxicity, based on the same principles, for incorporation in the other ITS. The technologies are deployed in a step-wise manner, as a basis for decision-tree approaches, incorporating weight-of-evidence stages. This means that testing can be stopped at the point where a risk assessment and/or classification can be performed, with labelling in accordance with the requirements of the regulatory authority concerned, rather than following a checklist approach to hazard identification. In addition, the strategies are intelligent, in that they are based on the fundamental premise that there is no hazard in the absence of exposure - which is why pharmacokinetic modelling plays a key role in each ITS. The new technologies include the use of complex, three-dimensional human cell tissue culture systems with in vivo-like structural, physiological and biochemical features, as well as dosing conditions. In this way, problems of inter-species extrapolation and in vitro/in vivo extrapolation are minimised. This is reflected in the ITS placing more emphasis on the use of volunteers at the whole organism testing stage, rather than on existing animal testing, which is the current situation.

  15. Multilevel Optimization Framework for Hierarchical Stiffened Shells Accelerated by Adaptive Equivalent Strategy

    NASA Astrophysics Data System (ADS)

    Wang, Bo; Tian, Kuo; Zhao, Haixin; Hao, Peng; Zhu, Tianyu; Zhang, Ke; Ma, Yunlong

    2016-09-01

    In order to improve the post-buckling optimization efficiency of hierarchical stiffened shells, a multilevel optimization framework accelerated by adaptive equivalent strategy is presented in this paper. Firstly, the Numerical-based Smeared Stiffener Method (NSSM) for hierarchical stiffened shells is derived by means of the numerical implementation of asymptotic homogenization (NIAH) method. Based on the NSSM, a reasonable adaptive equivalent strategy for hierarchical stiffened shells is developed from the concept of hierarchy reduction. Its core idea is to self-adaptively decide which hierarchy of the structure should be equivalent according to the critical buckling mode rapidly predicted by NSSM. Compared with the detailed model, the high prediction accuracy and efficiency of the proposed model is highlighted. On the basis of this adaptive equivalent model, a multilevel optimization framework is then established by decomposing the complex entire optimization process into major-stiffener-level and minor-stiffener-level sub-optimizations, during which Fixed Point Iteration (FPI) is employed to accelerate convergence. Finally, the illustrative examples of the multilevel framework is carried out to demonstrate its efficiency and effectiveness to search for the global optimum result by contrast with the single-level optimization method. Remarkably, the high efficiency and flexibility of the adaptive equivalent strategy is indicated by compared with the single equivalent strategy.

  16. 78 FR 19514 - National Fish, Wildlife, and Plants Climate Adaptation Strategy

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-01

    ... Fish and Wildlife Service National Fish, Wildlife, and Plants Climate Adaptation Strategy AGENCY: Fish..., Wildlife, and Plants Climate Adaptation Strategy (NFWPCAS or Strategy). The purpose of the Strategy is to... Advisor, Attn: National Fish, Wildlife, and Plants Climate Adaptation Strategy, U.S. Fish and...

  17. Patients with Parkinson's disease can employ a predictive motor strategy.

    PubMed Central

    Day, B L; Dick, J P; Marsden, C D

    1984-01-01

    We have tested the hypothesis that predictive motor behaviour is abnormal in Parkinson's disease. In the first experiment elbow movements were performed to track a moving spot on an oscilloscope screen. The performance of 12 patients with Parkinson's disease and eight age-matched control subjects was measured when tracking a repeated pattern under two conditions. In the first condition subjects were not aware of the repetitive nature of the tracking task whilst in the second condition they were. For both groups tracking error and tracking lag were less when aware of the repetition. In the second experiment wrist movements were studied. Five age-matched controls were compared with five patients, studied on and off drugs. In this experiment the performance tracking a repeated pattern was compared to that tracking unpredictable patterns. Tracking lags were reduced to very low values (less than 20 ms) in response to the repeated pattern for both groups. This was true even when the patients were relatively immobile off drugs. We conclude that patients with Parkinson's disease are capable of predictive motor behaviour although such a strategy does not always confer as great an advantage in reducing tracking error in patients compared with control subjects. PMID:6512550

  18. Adapting Strategies of Effective Instruction for Culturally Diverse Preschoolers

    ERIC Educational Resources Information Center

    Yamauchi, Lois A.; Im, Seongah; Schonleber, Nanette S.

    2012-01-01

    This article describes collaboration between preschool and university educators focused on adapting the Center for Research on Education, Diversity, and Excellence (CREDE) standards for Effective Pedagogy for use in early childhood (EC) settings. The CREDE standards are strategies of best practices for culturally diverse K-12 students. Teachers…

  19. Adaptive Insecure Attachment and Resource Control Strategies during Middle Childhood

    ERIC Educational Resources Information Center

    Chen, Bin-Bin; Chang, Lei

    2012-01-01

    By integrating the life history theory of attachment with resource control theory, the current study examines the hypothesis that insecure attachment styles reorganized in middle childhood are alternative adaptive strategies used to prepare for upcoming competition with the peer group. A sample of 654 children in the second through seventh grades…

  20. Adaptive mesh refinement strategies in isogeometric analysis— A computational comparison

    NASA Astrophysics Data System (ADS)

    Hennig, Paul; Kästner, Markus; Morgenstern, Philipp; Peterseim, Daniel

    2017-04-01

    We explain four variants of an adaptive finite element method with cubic splines and compare their performance in simple elliptic model problems. The methods in comparison are Truncated Hierarchical B-splines with two different refinement strategies, T-splines with the refinement strategy introduced by Scott et al. in 2012, and T-splines with an alternative refinement strategy introduced by some of the authors. In four examples, including singular and non-singular problems of linear elasticity and the Poisson problem, the H1-errors of the discrete solutions, the number of degrees of freedom as well as sparsity patterns and condition numbers of the discretized problem are compared.

  1. Health Resources and Strategies among Employed Women in Norway during Pregnancy and Early Motherhood.

    PubMed

    Alstveit, Marit; Severinsson, Elisabeth; Karlsen, Bjørg

    2015-01-01

    The number of women in paid employment is increasing. However, when becoming a mother for the first time, many seem unprepared for the challenge of balancing motherhood and work as well as for the impact on their health. The aim of this study was to investigate the health resources and strategies of employed women in Norway during pregnancy and early motherhood by means of salutogenic theory. A hypothetical-deductive interpretive approach based on Antonovsky's salutogenic theory was applied in a secondary analysis. A total of six themes were identified; three were classified as health resources when experiencing tension and three as health strategies. Salutogenic theory seems to be a useful framework for illuminating the health resources and strategies adopted by employed women who become mothers. The identified health resources when experiencing tension and the health strategies applied may have implications for maternity care professionals and employers in promoting the health of such women and supporting them to combine work and family life.

  2. Self-Adaptive Differential Evolution Algorithm With Zoning Evolution of Control Parameters and Adaptive Mutation Strategies.

    PubMed

    Fan, Qinqin; Yan, Xuefeng

    2016-01-01

    The performance of the differential evolution (DE) algorithm is significantly affected by the choice of mutation strategies and control parameters. Maintaining the search capability of various control parameter combinations throughout the entire evolution process is also a key issue. A self-adaptive DE algorithm with zoning evolution of control parameters and adaptive mutation strategies is proposed in this paper. In the proposed algorithm, the mutation strategies are automatically adjusted with population evolution, and the control parameters evolve in their own zoning to self-adapt and discover near optimal values autonomously. The proposed algorithm is compared with five state-of-the-art DE algorithm variants according to a set of benchmark test functions. Furthermore, seven nonparametric statistical tests are implemented to analyze the experimental results. The results indicate that the overall performance of the proposed algorithm is better than those of the five existing improved algorithms.

  3. Exposure to Stressful Environments: Strategy of Adaptive Responses

    NASA Technical Reports Server (NTRS)

    Farhi, Leon E.

    1991-01-01

    Any new natural environment may generate a number of stresses (such as hypoxia, water lack, and heat exposure), each of which can produce strains in more than a single organ system. Every strain may in turn stimulate the body to adapt in multiple ways. Nevertheless, a general strategy of the various adaptive responses emerges when the challenges are divided into three groups. The first category includes conditions that affect the supply of essential molecules, while the second is made up by those stresses that prevent the body from regulating properly the output of waste products, such as CO2 and heat. In both classes, there is a small number of responses, similar in principle, regardless of the specific situation. The third unit is created by environments that disrupt body transport systems. Problems may arise when there is a conflict between two stresses requiring conflicting adaptive changes. An alternative to adaptation, creation of micro-environment, is often favored by the animal.

  4. Assessment of the effectiveness of flood adaptation strategies for HCMC

    NASA Astrophysics Data System (ADS)

    Lasage, R.; Veldkamp, T. I. E.; de Moel, H.; Van, T. C.; Phi, H. L.; Vellinga, P.; Aerts, J. C. J. H.

    2014-06-01

    Coastal cities are vulnerable to flooding, and flood risk to coastal cities will increase due to sea-level rise. Moreover, Asian cities in particular are subject to considerable population growth and associated urban developments, increasing this risk even more. Empirical data on vulnerability and the cost and benefits of flood risk reduction measures are therefore paramount for sustainable development of these cities. This paper presents an approach to explore the impacts of sea-level rise and socio-economic developments on flood risk for the flood-prone District 4 in Ho Chi Minh City, Vietnam, and to develop and evaluate the effects of different adaptation strategies (new levees, dry- and wet proofing of buildings and elevating roads and buildings). A flood damage model was developed to simulate current and future flood risk using the results from a household survey to establish stage-damage curves for residential buildings. The model has been used to assess the effects of several participatory developed adaptation strategies to reduce flood risk, expressed in expected annual damage (EAD). Adaptation strategies were evaluated assuming combinations of both sea-level scenarios and land-use scenarios. Together with information on costs of these strategies, we calculated the benefit-cost ratio and net present value for the adaptation strategies until 2100, taking into account depreciation rates of 2.5% and 5%. The results of this modelling study indicate that the current flood risk in District 4 is USD 0.31 million per year, increasing up to USD 0.78 million per year in 2100. The net present value and benefit-cost ratios using a discount rate of 5 % range from USD -107 to -1.5 million, and from 0.086 to 0.796 for the different strategies. Using a discount rate of 2.5% leads to an increase in both net present value and benefit-cost ratio. The adaptation strategies wet-proofing and dry-proofing generate the best results using these economic indicators. The information

  5. Supporting Second Chances: Education and Employment Strategies For People Returning from Correctional Facilities

    ERIC Educational Resources Information Center

    Jobs For the Future, 2015

    2015-01-01

    This brief highlights strategies for strengthening education and employment pathways for youth and adults returning from correctional facilities and notes key questions that new research should answer. It also explores barriers to employment for people with criminal records--whether or not they have been incarcerated--and potential policy…

  6. Self-Regulated Strategies Chinese Graduate Students Employ to Learn English at Three American Universities

    ERIC Educational Resources Information Center

    Ma, Wen; Wang, Chuang

    2012-01-01

    International students in the United States often employ culture-specific learning strategies to help them improve their proficiency in English. This study explored the use of self-regulated strategies by 49 Chinese graduate students from 24 fields of study at three universities in the Northeast. The research used the mixed survey method to…

  7. A Study of Metacognitive Strategies Employed by English Listeners in an EFL Setting

    ERIC Educational Resources Information Center

    Yang, Chunmei

    2009-01-01

    This paper presents a study on the metacognitive strategies employed by English listeners in an EFL setting. The results of the study reveal that the subjects used directed attention most frequently and they used monitoring least frequently. Besides, there are differences in the use of metacognitive strategies between successful and unsuccessful…

  8. Strategies Pregnant Rural Women Employ to Deal with Intimate Partner Violence

    ERIC Educational Resources Information Center

    Bhandari, Shreya; Bullock, Linda F. C.; Sharps, Phyllis W.

    2013-01-01

    This study explored strategies from the Intimate Partner Violence Strategy Index (IPVSI) that a sub-set of 20 rural, low-income, abused women of a larger, multi-site, mixed-method study employed to deal with Intimate Partner Violence (IPV) during the perinatal period. We conducted 32 in-depth interviews with women who were pregnant (N = 12) and/or…

  9. Controls on Extreme Droughts and Adaptation Strategies in Semiarid Regions

    NASA Astrophysics Data System (ADS)

    Scanlon, B. R.; Cook, C.; Fernando, D. N.; LeBlanc, M.

    2012-12-01

    Increasing vulnerability to droughts with reduced per capita water storage, particularly in semiarid regions, underscores the need for predictive understanding of drought controls and development of adaptation strategies for water resources management. In this study we evaluate causes of major droughts in southwest and southcentral US (California and Texas) and southeast Australia (Murray Darling Basin). Impacts of climate cycles (ENSO, PDO, AMO, NAO, IOD) and atmospheric circulation on drought initiation and persistence are examined. Effects of drought on surface water reservoir storage, groundwater storage, irrigation, and crop production are compared. Adaptation strategies being evaluated include water transfers among sectors, particularly from irrigated agriculture to other groups, increasing storage using managed aquifer recharge, water reuse, and development of new water sources (e.g. seawater desalination). It is critical to develop a broad portfolio of water sources to increase resilience to future droughts.

  10. Diversity of immune strategies explained by adaptation to pathogen statistics

    PubMed Central

    Mayer, Andreas; Mora, Thierry; Rivoire, Olivier; Walczak, Aleksandra M.

    2016-01-01

    Biological organisms have evolved a wide range of immune mechanisms to defend themselves against pathogens. Beyond molecular details, these mechanisms differ in how protection is acquired, processed, and passed on to subsequent generations—differences that may be essential to long-term survival. Here, we introduce a mathematical framework to compare the long-term adaptation of populations as a function of the pathogen dynamics that they experience and of the immune strategy that they adopt. We find that the two key determinants of an optimal immune strategy are the frequency and the characteristic timescale of the pathogens. Depending on these two parameters, our framework identifies distinct modes of immunity, including adaptive, innate, bet-hedging, and CRISPR-like immunities, which recapitulate the diversity of natural immune systems. PMID:27432970

  11. Age-Related Differences in Locomotor Strategies During Adaptive Walking.

    PubMed

    Lowry, Kristin A; Sebastian, Katherine; Perera, Subashan; Van Swearingen, Jessie; Smiley-Oyen, Ann L

    2016-11-21

    Simultaneous control of lower limb stepping movements and trunk motion is important for skilled walking; adapting gait to environmental constraints requires frequent alternations in stepping and trunk motion. These alterations provide a window into the locomotor strategies adopted by the walker. The authors examined gait strategies in young and healthy older adults when manipulating step width. Anteroposterior (AP) and mediolateral (ML) smoothness (quantified by harmonic ratios) and stepping consistency (quantified by gait variability) were analyzed during narrow and wide walking while controlling cadence to preferred pace. Results indicated older adults preserved ML smoothness at the expense of AP smoothness, shortened their steps, and exhibited reduced stepping consistency. The authors conclude that older adults prioritized ML control over forward progression during adaptive walking challenges.

  12. Climate change impacts and adaptive strategies: lessons from the grapevine.

    PubMed

    Mosedale, Jonathan R; Abernethy, Kirsten E; Smart, Richard E; Wilson, Robert J; Maclean, Ilya M D

    2016-11-01

    The cultivation of grapevines for winemaking, known as viticulture, is widely cited as a climate-sensitive agricultural system that has been used as an indicator of both historic and contemporary climate change. Numerous studies have questioned the viability of major viticulture regions under future climate projections. We review the methods used to study the impacts of climate change on viticulture in the light of what is known about the effects of climate and weather on the yields and quality of vineyard harvests. Many potential impacts of climate change on viticulture, particularly those associated with a change in climate variability or seasonal weather patterns, are rarely captured. Key biophysical characteristics of viticulture are often unaccounted for, including the variability of grapevine phenology and the exploitation of microclimatic niches that permit successful cultivation under suboptimal macroclimatic conditions. We consider how these same biophysical characteristics permit a variety of strategies by which viticulture can adapt to changing climatic conditions. The ability to realize these strategies, however, is affected by uneven exposure to risks across the winemaking sector, and the evolving capacity for decision-making within and across organizational boundaries. The role grape provenance plays in shaping perceptions of wine value and quality illustrates how conflicts of interest influence decisions about adaptive strategies within the industry. We conclude by considering what lessons can be taken from viticulture for studies of climate change impacts and the capacity for adaptation in other agricultural and natural systems.

  13. Adaptive strategies to climate change in Southern Malawi

    NASA Astrophysics Data System (ADS)

    Chidanti-Malunga, J.

    Climate change poses a big challenge to rural livelihoods in the Shire Valley area of Southern Malawi, where communities have depended almost entirely on rain-fed agriculture for generations. The Shire Valley area comprises of low-altitude dambo areas and uplands which have been the main agricultural areas. Since early to mid 1980s, the uplands have experienced prolonged droughts and poor rainfall distribution, while the dambos have experienced recurrent seasonal floods. This study assessed some of the adaptive strategies exercised by small-scale rural farmers in response to climate change in the Shire Valley. The methodology used in collecting information includes group discussions, household surveys in the area, secondary data, and field observations. The results show that small-scale rural farmers exercise a number of adaptive strategies in response to climate change. These adaptive strategies include: increased use of water resources for small-scale irrigation or wetland farming, mostly using simple delivery techniques; increased management of residual moisture; and increased alternative sources of income such as fishing and crop diversity. It was also observed that government promoted the use of portable motorized pumps for small-scale irrigation in order to mitigate the effects of climate change. However, these external interventions were not fully adopted; instead the farmers preferred local interventions which mostly had indigenous elements.

  14. Design and Flight Tests of an Adaptive Control System Employing Normal-Acceleration Command

    NASA Technical Reports Server (NTRS)

    McNeill, Water E.; McLean, John D.; Hegarty, Daniel M.; Heinle, Donovan R.

    1961-01-01

    An adaptive control system employing normal-acceleration command has been designed with the aid of an analog computer and has been flight tested. The design of the system was based on the concept of using a mathematical model in combination with a high gain and a limiter. The study was undertaken to investigate the application of a system of this type to the task of maintaining nearly constant dynamic longitudinal response of a piloted airplane over the flight envelope without relying on air data measurements for gain adjustment. The range of flight conditions investigated was between Mach numbers of 0.36 and 1.15 and altitudes of 10,000 and 40,000 feet. The final adaptive system configuration was derived from analog computer tests, in which the physical airplane control system and much of the control circuitry were included in the loop. The method employed to generate the feedback signals resulted in a model whose characteristics varied somewhat with changes in flight condition. Flight results showed that the system limited the variation in longitudinal natural frequency of the adaptive airplane to about half that of the basic airplane and that, for the subsonic cases, the damping ratio was maintained between 0.56 and 0.69. The system also automatically compensated for the transonic trim change. Objectionable features of the system were an exaggerated sensitivity of pitch attitude to gust disturbances, abnormally large pitch attitude response for a given pilot input at low speeds, and an initial delay in normal-acceleration response to pilot control at all flight conditions. The adaptive system chatter of +/-0.05 to +/-0.10 of elevon at about 9 cycles per second (resulting in a maximum airplane normal-acceleration response of from +/-0.025 g to +/- 0.035 g) was considered by the pilots to be mildly objectionable but tolerable.

  15. A Climate Change Adaptation Strategy for Management of ...

    EPA Pesticide Factsheets

    Sea level rise is causing shoreline erosion, increased coastal flooding, and marsh vulnerability to the impact of storms. Coastal marshes provide flood abatement, carbon and nutrient sequestration, water quality maintenance, and habitat for fish, shellfish, and wildlife, including species of concern, such as the saltmarsh sparrow (Ammodramus caudacutus). We present a climate change adaptation strategy (CCAS) adopted by scientific, management, and policy stakeholders for managing coastal marshes and enhancing system resiliency. A common adaptive management approach previously used for restoration projects was modified to identify climate-related vulnerabilities and plan climate change adaptive actions. As an example of implementation of the CCAS, we describe the stakeholder plans and management actions the US Fish and Wildlife Service and partners developed to build coastal resiliency in the Narrow River Estuary, RI, in the aftermath of Superstorm Sandy. When possible, an experimental BACI (before-after, control-impact) design, described as pre- and post-sampling at the impact site and one or more control sites, was incorporated into the climate change adaptation and implementation plans. Specific climate change adaptive actions and monitoring plans are described and include shoreline stabilization, restoring marsh drainage, increasing marsh elevation, and enabling upland marsh migration. The CCAS provides a framework and methodology for successfully managing coa

  16. Readapting the adaptive immune response - therapeutic strategies for atherosclerosis.

    PubMed

    Sage, Andrew P; Mallat, Ziad

    2017-01-04

    Cardiovascular diseases remain a major global health issue, with the development of atherosclerosis as a major underlying cause. Our treatment of cardiovascular disease has improved greatly over the past three decades, but much remains to be done reduce disease burden. Current priorities include reducing atherosclerosis advancement to clinically significant stages and preventing plaque rupture or erosion. Inflammation and involvement of the adaptive immune system influences all these aspects and therefore is one focus for future therapeutic development. The atherosclerotic vascular wall is now recognized to be invaded from both sides (arterial lumen and adventitia), for better or worse, by the adaptive immune system. Atherosclerosis is also affected at several stages by adaptive immune responses, overall providing many opportunities to target these responses and to reduce disease progression. Protective influences that may be defective in diseased individuals include humoral responses to modified LDL and regulatory T cell responses. There are many strategies in development to boost these pathways in humans, including vaccine-based therapies. The effects of various existing adaptive immune targeting therapies, such as blocking critical co-stimulatory pathways or B cell depletion, on cardiovascular disease are beginning to emerge with important consequences for both autoimmune disease patients and the potential for wider use of such therapies. Entering the translation phase for adaptive immune targeting therapies is an exciting and promising prospect.

  17. "A lot of sacrifices:" work-family spillover and the food choice coping strategies of low-wage employed parents.

    PubMed

    Devine, Carol M; Jastran, Margaret; Jabs, Jennifer; Wethington, Elaine; Farell, Tracy J; Bisogni, Carole A

    2006-11-01

    Integrating their work and family lives is an everyday challenge for employed parents. Competing demands for parents' time and energy may contribute to fewer meals prepared or eaten at home and poorer nutritional quality of meals. Thus, work-family spillover (feelings, attitudes, and behaviors carried over from one role to another) is a phenomenon with implications for nutrition and health. The aim of this theory-guided constructivist research was to understand how low-wage employed parents' experiences of work-family spillover affected their food choice coping strategies. Participants were 69 black, white and Latino mothers and fathers in a Northeastern US city. We explored participants' understandings of family and work roles, spillover, and food choice strategies using open-ended qualitative interviews. Data analysis was based on the constant comparative method. These parents described affective, evaluative, and behavioral instances of work-family spillover and role overload as normative parts of everyday life and dominant influences on their food choices. They used food choice coping strategies to: (1) manage feelings of stress and fatigue, (2) reduce the time and effort for meals, (3) redefine meanings and reduce expectations for food and eating, and (4) set priorities and trade off food and eating against other family needs. Only a few parents used adaptive strategies that changed work or family conditions to reduce the experience of conflict. Most coping strategies were aimed at managing feelings and redefining meanings, and were inadequate for reducing the everyday hardships from spillover and role overload. Some coping strategies exacerbated feelings of stress. These findings have implications for family nutrition, food expenditures, nutritional self-efficacy, social connections, food assistance policy, and work place strategies.

  18. Adaptation of enzymes to temperature: searching for basic "strategies".

    PubMed

    Somero, George N

    2004-11-01

    The pervasive influence of temperature on biological systems necessitates a suite of temperature--compensatory adaptations that span all levels of biological organization--from behavior to fine-scale molecular structure. Beginning about 50 years ago, physiological studies conducted with whole organisms or isolated tissues, by such pioneers of comparative thermal physiology as V.Ya. Alexandrov, T.H. Bullock, F.E.J. Fry, H. Precht, C.L. Prosser, and P.F. Scholander, began to document in detail the abilities of ectothermic animals to sustain relatively similar rates of metabolic activity at widely different temperatures of adaptation or acclimation. These studies naturally led to investigation of the roles played by enzymatic proteins in metabolic temperature compensation. Peter Hochachka's laboratory became an epicenter of this new focus in comparative physiology. The studies of the enzyme lactate dehydrogenase (LDH) that he initiated as a PhD student at Duke University in the mid-1960s and continued for several years at the University of British Columbia laid much of the foundation for subsequent studies of protein adaptation to temperature. Studies of orthologs of LDH have revealed the importance of conserving kinetic properties (catalytic rate constants (kcat) and Michaelis-Menten constants (Km) and structural stability during adaptation to temperature, and recently have identified the types of amino acid substitutions causing this adaptive variation. The roles of pH and low-molecular-mass organic solutes (osmolytes) in conserving the functional and structural properties of enzymes also have been elucidated using LDH. These studies, begun in Peter Hochachka's laboratory almost 40 years ago, have been instrumental in the development of a conceptual framework for the study of biochemical adaptation, a field whose origin can be traced largely to his creative influences. This framework emphasizes the complementary roles of three "strategies" of adaptation: (1) changes

  19. Rhesus monkeys employ a procedural strategy to reduce working memory load in a self-ordered spatial search task.

    PubMed

    Taffe, Michael A; Taffe, William J

    2011-09-21

    Several nonhuman primate species have been reported to employ a distance-minimizing, traveling salesman-like, strategy during foraging as well as in experimental spatial search tasks involving lesser amounts of locomotion. Spatial sequencing may optimize performance by reducing reference or episodic memory loads, locomotor costs, competition or other demands. A computerized self-ordered spatial search (SOSS) memory task has been adapted from a human neuropsychological testing battery (CANTAB, Cambridge Cognition, Ltd) for use in monkeys. Accurate completion of a trial requires sequential responses to colored boxes in two or more spatial locations without repetition of a previous location. Marmosets have been reported to employ a circling pattern of search, suggesting spontaneous adoption of a strategy to reduce working memory load. In this study the SOSS performance of rhesus monkeys was assessed to determine if the use of a distance-minimizing search path enhances accuracy. A novel strategy score, independent of the trial difficulty and arrangement of boxes, has been devised. Analysis of the performance of 21 monkeys trained on SOSS over 2 years shows that a distance-minimizing search strategy is associated with improved accuracy. This effect is observed within individuals as they improve over many cumulative sessions of training on the task and across individuals at any given level of training. Erroneous trials were associated with a failure to deploy the strategy. It is concluded that the effect of utilizing the strategy on this locomotion-free, laboratory task is to enhance accuracy by reducing demands on spatial working memory resources.

  20. Climate change adaptation strategies for resource management and conservation planning.

    PubMed

    Lawler, Joshua J

    2009-04-01

    Recent rapid changes in the Earth's climate have altered ecological systems around the globe. Global warming has been linked to changes in physiology, phenology, species distributions, interspecific interactions, and disturbance regimes. Projected future climate change will undoubtedly result in even more dramatic shifts in the states of many ecosystems. These shifts will provide one of the largest challenges to natural resource managers and conservation planners. Managing natural resources and ecosystems in the face of uncertain climate requires new approaches. Here, the many adaptation strategies that have been proposed for managing natural systems in a changing climate are reviewed. Most of the recommended approaches are general principles and many are tools that managers are already using. What is new is a turning toward a more agile management perspective. To address climate change, managers will need to act over different spatial and temporal scales. The focus of restoration will need to shift from historic species assemblages to potential future ecosystem services. Active adaptive management based on potential future climate impact scenarios will need to be a part of everyday operations. And triage will likely become a critical option. Although many concepts and tools for addressing climate change have been proposed, key pieces of information are still missing. To successfully manage for climate change, a better understanding will be needed of which species and systems will likely be most affected by climate change, how to preserve and enhance the evolutionary capacity of species, how to implement effective adaptive management in new systems, and perhaps most importantly, in which situations and systems will the general adaptation strategies that have been proposed work and how can they be effectively applied.

  1. Successful adaption of a forensic toxicological screening workflow employing nontargeted liquid chromatography-tandem mass spectrometry to water analysis.

    PubMed

    Steger, Julia; Arnhard, Kathrin; Haslacher, Sandra; Geiger, Klemens; Singer, Klaus; Schlapp, Michael; Pitterl, Florian; Oberacher, Herbert

    2016-04-01

    Forensic toxicology and environmental water analysis share the common interest and responsibility in ensuring comprehensive and reliable confirmation of drugs and pharmaceutical compounds in samples analyzed. Dealing with similar analytes, detection and identification techniques should be exchangeable between scientific disciplines. Herein, we demonstrate the successful adaption of a forensic toxicological screening workflow employing nontargeted LC/MS/MS under data-dependent acquisition control and subsequent database search to water analysis. The main modification involved processing of an increased sample volume with SPE (500 mL vs. 1-10 mL) to reach LODs in the low ng/L range. Tandem mass spectra acquired with a qTOF instrument were submitted to database search. The targeted data mining strategy was found to be sensitive and specific; automated search produced hardly any false results. To demonstrate the applicability of the adapted workflow to complex samples, 14 wastewater effluent samples collected on seven consecutive days at the local wastewater-treatment plant were analyzed. Of the 88,970 fragment ion mass spectra produced, 8.8% of spectra were successfully assigned to one of the 1040 reference compounds included in the database, and this enabled the identification of 51 compounds representing important illegal drugs, members of various pharmaceutical compound classes, and metabolites thereof.

  2. Strategies of Adaptation: A Soviet Enterprise Under Perestroika and Privatization

    DTIC Science & Technology

    1991-06-01

    the early 1970’s (see Il’in, 1973; Gorlin , 1976), we have referred to it as an enterprise throughout this paper. Strateaies of Adaptation 5 convinced...fact, some refer to it as "Shop 1." "See Il’in (1973) and Gorlin (1976) for a discussion of the policy of consolidating enterprises into production...34edineniia. ( Gorlin , 1976; Il’in, 1973) This was encouraged by the state but it also complemented the enterprise strategy of increasing bargaining power

  3. Adaptive strategy for multi-user robotic rehabilitation games.

    PubMed

    Caurin, Glauco A P; Siqueira, Adriano A G; Andrade, Kleber O; Joaquim, Ricardo C; Krebs, Hermano I

    2011-01-01

    In this paper, we discuss a strategy for the adaptation of the "difficulty level" in games intended to include motor planning during robotic rehabilitation. We consider concurrently the motivation of the user and his/her performance in a Pong game. User motivation is classified in three levels (not motivated, well motivated and overloaded). User performance is measured as a combination of knowledge of results--achieved goals and score points in the game--and knowledge of performance--joint displacement, speed, aiming, user work, etc. Initial results of a pilot test with unimpaired healthy young volunteers are also presented showing a tendency for individualization of the parameter values.

  4. Strategies Employed by Iranian EFL Freshman University Students in Extensive Listening: A Qualitative Research

    ERIC Educational Resources Information Center

    Bidabadi, Farinaz Shirani; Yamat, Hamidah

    2014-01-01

    This paper discusses the findings of a qualitative study on the strategies employed by Iranian freshmen in extensive listening. A group of 12 freshman university students were purposefully selected based on their scores in the Oxford Placement Test administered. Four learners were identified as advanced, four as intermediate, and four as lower…

  5. Health Resources and Strategies among Employed Women in Norway during Pregnancy and Early Motherhood

    PubMed Central

    Alstveit, Marit; Karlsen, Bjørg

    2015-01-01

    The number of women in paid employment is increasing. However, when becoming a mother for the first time, many seem unprepared for the challenge of balancing motherhood and work as well as for the impact on their health. The aim of this study was to investigate the health resources and strategies of employed women in Norway during pregnancy and early motherhood by means of salutogenic theory. A hypothetical-deductive interpretive approach based on Antonovsky's salutogenic theory was applied in a secondary analysis. A total of six themes were identified; three were classified as health resources when experiencing tension and three as health strategies. Salutogenic theory seems to be a useful framework for illuminating the health resources and strategies adopted by employed women who become mothers. The identified health resources when experiencing tension and the health strategies applied may have implications for maternity care professionals and employers in promoting the health of such women and supporting them to combine work and family life. PMID:25945258

  6. Assessing University Students' Self-Efficacy to Employ Alcohol-Related Harm Reduction Strategies

    ERIC Educational Resources Information Center

    Rosenberg, Harold; Bonar, Erin E.; Hoffmann, Erica; Kryszak, Elizabeth; Young, Kathleen M.; Kraus, Shane W.; Ashrafioun, Lisham; Bannon, Erin E.; Pavlick, Michelle

    2011-01-01

    Objective: Develop and evaluate key psychometric properties of a self-report questionnaire specifically designed to assess student drinkers' self-confidence to employ a variety of strategies intended to reduce unhealthy consequences of high-risk drinking. Methods: Four hundred ninety-eight participants rated their confidence (from "not at all…

  7. Work Conditions and the Food Choice Coping Strategies of Employed Parents

    ERIC Educational Resources Information Center

    Devine, Carol M.; Farrell, Tracy J.; Blake, Christine E.; Jastran, Margaret; Wethington, Elaine; Bisogni, Carole A.

    2009-01-01

    Objective: How work conditions relate to parents' food choice coping strategies. Design: Pilot telephone survey. Setting: City in the northeastern United States (US). Participants: Black, white, and Hispanic employed mothers (25) and fathers (25) randomly recruited from low-/moderate-income zip codes; 78% of those reached and eligible…

  8. A control strategy for adaptive absorber based on variable mass

    NASA Astrophysics Data System (ADS)

    Gao, Qiang; Han, Ning; Zhao, Yanqing; Duan, Chendong; Wang, Wanqin

    2015-07-01

    The tuned vibration absorber (TVA) has been an effective tool for vibration control. However, the application of TVA can cause resonance of the primary system and increase its vibration when the absorber is mistuned. In this paper, a novel control strategy based on adaptive tuned vibration absorber (ATVA) of variable mass is proposed to reduce the resonance of the primary system. Unlike most ATVAs suggested by other researchers which adjust the absorber natural frequency by changing the stiffness, the variable mass ATVA varies its natural frequency by changing absorber mass to match the excitation frequency. Some simulations and experiments were conducted to test the performance of the control strategy. The results show that the proposed control plan can widen the frequency bandwidth of the absorber, as well as suppress the resonance of the primary system significantly. This implies that the work is useful for practical applications of ATVA.

  9. 76 FR 30193 - National Fish, Wildlife, and Plants Climate Adaptation Strategy; Notice of Intent: Request for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-24

    ... Fish and Wildlife Service National Fish, Wildlife, and Plants Climate Adaptation Strategy; Notice of... National Fish, Wildlife, and Plants Climate Adaptation Strategy (Strategy). The Strategy will provide a... ensure that we are able to consider your comments and information as we develop our draft...

  10. Adaptation and Validation of Self-Perceived Employability Scale: An Analysis of Sports Department Students and Graduates

    ERIC Educational Resources Information Center

    Karli, Unal

    2016-01-01

    The purpose of this study was twofold: first, to adapt and test the construct validity of the Self- Perceived Employability Scale; and second, to analyze the employability perceptions of students and graduates of sports departments according to their gender, level of education, ability to communicate in a foreign language, and work experience. A…

  11. Adaptive UAV Attitude Estimation Employing Unscented Kalman Filter, FOAM and Low-Cost MEMS Sensors

    PubMed Central

    de Marina, Héctor García; Espinosa, Felipe; Santos, Carlos

    2012-01-01

    Navigation employing low cost MicroElectroMechanical Systems (MEMS) sensors in Unmanned Aerial Vehicles (UAVs) is an uprising challenge. One important part of this navigation is the right estimation of the attitude angles. Most of the existent algorithms handle the sensor readings in a fixed way, leading to large errors in different mission stages like take-off aerobatic maneuvers. This paper presents an adaptive method to estimate these angles using off-the-shelf components. This paper introduces an Attitude Heading Reference System (AHRS) based on the Unscented Kalman Filter (UKF) using the Fast Optimal Attitude Matrix (FOAM) algorithm as the observation model. The performance of the method is assessed through simulations. Moreover, field experiments are presented using a real fixed-wing UAV. The proposed low cost solution, implemented in a microcontroller, shows a satisfactory real time performance. PMID:23012559

  12. Adaptive UAV attitude estimation employing unscented Kalman Filter, FOAM and low-cost MEMS sensors.

    PubMed

    de Marina, Héctor García; Espinosa, Felipe; Santos, Carlos

    2012-01-01

    Navigation employing low cost MicroElectroMechanical Systems (MEMS) sensors in Unmanned Aerial Vehicles (UAVs) is an uprising challenge. One important part of this navigation is the right estimation of the attitude angles. Most of the existent algorithms handle the sensor readings in a fixed way, leading to large errors in different mission stages like take-off aerobatic maneuvers. This paper presents an adaptive method to estimate these angles using off-the-shelf components. This paper introduces an Attitude Heading Reference System (AHRS) based on the Unscented Kalman Filter (UKF) using the Fast Optimal Attitude Matrix (FOAM) algorithm as the observation model. The performance of the method is assessed through simulations. Moreover, field experiments are presented using a real fixed-wing UAV. The proposed low cost solution, implemented in a microcontroller, shows a satisfactory real time performance.

  13. Design of Sequentially Randomized Trials for Testing Adaptive Treatment Strategies

    PubMed Central

    Ogbagaber, Semhar B.; Karp, Jordan; Wahed, Abdus S.

    2016-01-01

    An adaptive treatment strategy (ATS) is an outcome-guided algorithm that allows personalized treatment of complex diseases based on patients’ disease status and treatment history. Conditions such as AIDS, depression, and cancer usually require several stages of treatment due to the chronic, multifactorial nature of illness progression and management. Sequential multiple assignment randomized (SMAR) designs permit simultaneous inference about multiple ATSs, where patients are sequentially randomized to treatments at different stages depending upon response status. The purpose of the article is to develop a sample size formula to ensure adequate power for comparing two or more ATSs. Based on a Wald-type statistic for comparing multiple ATSs with a continuous endpoint, we develop a sample size formula and test it through simulation studies. We show via simulation that the proposed sample size formula maintains the nominal power. The proposed sample size formula is not applicable to designs with time-to-event endpoints but the formula will be useful for practitioners while designing SMAR trials to compare adaptive treatment strategies. PMID:26412033

  14. Alternative adaptive immunity strategies: coelacanth, cod and shark immunity.

    PubMed

    Buonocore, Francesco; Gerdol, Marco

    2016-01-01

    The advent of high throughput sequencing has permitted to investigate the genome and the transcriptome of novel non-model species with unprecedented depth. This technological advance provided a better understanding of the evolution of adaptive immune genes in gnathostomes, revealing several unexpected features in different fish species which are of particular interest. In the present paper, we review the current understanding of the adaptive immune system of the coelacanth, the elephant shark and the Atlantic cod. The study of coelacanth, the only living extant of the long thought to be extinct Sarcopterygian lineage, is fundamental to bring new insights on the evolution of the immune system in higher vertebrates. Surprisingly, coelacanths are the only known jawed vertebrates to lack IgM, whereas two IgD/W loci are present. Cartilaginous fish are of great interest due to their basal position in the vertebrate tree of life; the genome of the elephant shark revealed the lack of several important immune genes related to T cell functions, which suggest the existence of a primordial set of TH1-like cells. Finally, the Atlantic cod lacks a functional major histocompatibility II complex, but balances this evolutionary loss with the expansion of specific gene families, including MHC I, Toll-like receptors and antimicrobial peptides. Overall, these data point out that several fish species present an unconventional adaptive immune system, but the loss of important immune genes is balanced by adaptive evolutionary strategies which still guarantee the establishment of an efficient immune response against the pathogens they have to fight during their life.

  15. Adaptive and Qualitative Changes in Encoding Strategy With Experience: Evidence From the Test-Expectancy Paradigm

    PubMed Central

    Finley, Jason R.; Benjamin, Aaron S.

    2012-01-01

    Three experiments demonstrated learners’ abilities to adaptively and qualitatively accommodate their encoding strategies to the demands of an upcoming test. Stimuli were word pairs. In Experiment 1, test expectancy was induced for either cued recall (of targets given cues) or free recall (of targets only) across 4 study–test cycles of the same test format, followed by a final critical cycle featuring either the expected or the unexpected test format. For final tests of both cued and free recall, participants who had expected that test format outperformed those who had not. This disordinal interaction, supported by recognition and self-report data, demonstrated not mere differences in effort based on anticipated test difficulty, but rather qualitative and appropriate differences in encoding strategies based on expected task demands. Participants also came to appropriately modulate metacognitive monitoring (Experiment 2) and study-time allocation (Experiment 3) across study–test cycles. Item and associative recognition performance, as well as self-report data, revealed shifts in encoding strategies across trials; these results were used to characterize and evaluate the different strategies that participants employed for cued versus free recall and to assess the optimality of participants’ metacognitive control of encoding strategies. Taken together, these data illustrate a sophisticated form of metacognitive control, in which learners qualitatively shift encoding strategies to match the demands of anticipated tests. PMID:22103783

  16. Adaptive and qualitative changes in encoding strategy with experience: evidence from the test-expectancy paradigm.

    PubMed

    Finley, Jason R; Benjamin, Aaron S

    2012-05-01

    Three experiments demonstrated learners' abilities to adaptively and qualitatively accommodate their encoding strategies to the demands of an upcoming test. Stimuli were word pairs. In Experiment 1, test expectancy was induced for either cued recall (of targets given cues) or free recall (of targets only) across 4 study-test cycles of the same test format, followed by a final critical cycle featuring either the expected or the unexpected test format. For final tests of both cued and free recall, participants who had expected that test format outperformed those who had not. This disordinal interaction, supported by recognition and self-report data, demonstrated not mere differences in effort based on anticipated test difficulty, but rather qualitative and appropriate differences in encoding strategies based on expected task demands. Participants also came to appropriately modulate metacognitive monitoring (Experiment 2) and study-time allocation (Experiment 3) across study-test cycles. Item and associative recognition performance, as well as self-report data, revealed shifts in encoding strategies across trials; these results were used to characterize and evaluate the different strategies that participants employed for cued versus free recall and to assess the optimality of participants' metacognitive control of encoding strategies. Taken together, these data illustrate a sophisticated form of metacognitive control, in which learners qualitatively shift encoding strategies to match the demands of anticipated tests.

  17. Forest adjacent households' voices on their perceptions and adaptation strategies to climate change in Kilombero District, Tanzania.

    PubMed

    Balama, Chelestino; Augustino, Suzana; Eriksen, Siri; Makonda, Fortunatus B S

    2016-01-01

    Climate change is a global and local challenge to both sustainable livelihoods and economic development. Tanzania as other countries of the world has been affected. Several studies have been conducted on farmers' perceptions and adaptation to climate change in the country, but little attention has been devoted to forest adjacent households in humid areas. This study assessed this gap through assessing forest adjacent households' voices on perceptions and adaptation strategies to climate change in Kilombero District, Tanzania. Data collection involved key informant interviews, focus group discussions and household questionnaires. Results showed that the majority of households perceived changed climate in terms of temperature increase, unpredictable rainfall, frequent occurrence of floods, increased dry spells during rainy season coupled with decreased water sources and emergence of new pests and diseases. The perceived change in climate has impacted agriculture productivity as the main livelihood source. Different coping and adaptation strategies are employed. These are; crop diversification, changing cropping calendar, adopting modern farming technologies, and increasing reliance on non-timber forest products. These strategies were positively and significantly influenced by socio-economic factors including household size, residence period, land ownership and household income. The study concludes that, there are changes in climatic conditions; and to respond to these climatic changes, forest adjacent households have developed numerous coping and adaptation strategies, which were positively and significantly influenced by some socio-economic factors. The study calls for actual implementation of local climate change policies and strategies in order to enhance adaptive capacity at household level.

  18. Employment Status and Mental Health: Mediating Roles of Social Support and Coping Strategies.

    PubMed

    Perreault, Michel; Touré, El Hadj; Perreault, Nicole; Caron, Jean

    2016-08-27

    Although it has been established that unemployment and underemployment increase distress and depression, the psychological mechanisms involved are not very clear. This study examines the roles of social support and coping strategies as mediators of the association between employment status and mental health, as well as gender and age differences as moderators. Residents from the epidemiological catchment area of south-west Montreal responded to a randomized household survey for adults in 2009. A follow-up was conducted based on participants' employment status 2 and 4 years later. ANOVAs tests were computed with SPSS to evaluate group differences, and structural equation modeling was performed with AMOS to test mediation effects. At baseline, among participants between 18 and 64 years old (n = 2325), 14.3 % were unemployed/not studying, 14.4 % worked part-time, and 56.5 % worked full-time. Employment status was found to significantly affect depression among those under 45 years old (chi-square = 23.4, p < 0.001). Results showed a negative association of full-time employment with depression, which was fully mediated by social support, less coping with drugs/medication, and less distress. A negative association with full-time employment was also noted with distress, which was partially mediated by increased social support, coping with alcohol, and less coping with drugs/medication. The total indirect effect suggests that full-time employees generally have more resources and do not tend to use avoidance strategies like coping with drugs/medication, resulting in less distress (β = -0.05; p < 0.01) and depression (β = -0.028; p < 0.01). Results suggest that optimal impact on mental health could be attained when increasing employment, namely full-time employment, in communities.

  19. Delayed feedback during sensorimotor learning selectively disrupts adaptation but not strategy use

    PubMed Central

    Brudner, Samuel N.; Kethidi, Nikhit; Graeupner, Damaris; Ivry, Richard B.

    2016-01-01

    In sensorimotor adaptation tasks, feedback delays can cause significant reductions in the rate of learning. This constraint is puzzling given that many skilled behaviors have inherently long delays (e.g., hitting a golf ball). One difference in these task domains is that adaptation is primarily driven by error-based feedback, whereas skilled performance may also rely to a large extent on outcome-based feedback. This difference suggests that error- and outcome-based feedback may engage different learning processes, and these processes may be associated with different temporal constraints. We tested this hypothesis in a visuomotor adaptation task. Error feedback was indicated by the terminal position of a cursor, while outcome feedback was indicated by points. In separate groups of participants, the two feedback signals were presented immediately at the end of the movement, after a delay, or with just the error feedback delayed. Participants learned to counter the rotation in a similar manner regardless of feedback delay. However, the aftereffect, an indicator of implicit motor adaptation, was attenuated with delayed error feedback, consistent with the hypothesis that a different learning process supports performance under delay. We tested this by employing a task that dissociates the contribution of explicit strategies and implicit adaptation. We find that explicit aiming strategies contribute to the majority of the learning curve, regardless of delay; however, implicit learning, measured over the course of learning and by aftereffects, was significantly attenuated with delayed error-based feedback. These experiments offer new insight into the temporal constraints associated with different motor learning processes. PMID:26792878

  20. Delayed feedback during sensorimotor learning selectively disrupts adaptation but not strategy use.

    PubMed

    Brudner, Samuel N; Kethidi, Nikhit; Graeupner, Damaris; Ivry, Richard B; Taylor, Jordan A

    2016-03-01

    In sensorimotor adaptation tasks, feedback delays can cause significant reductions in the rate of learning. This constraint is puzzling given that many skilled behaviors have inherently long delays (e.g., hitting a golf ball). One difference in these task domains is that adaptation is primarily driven by error-based feedback, whereas skilled performance may also rely to a large extent on outcome-based feedback. This difference suggests that error- and outcome-based feedback may engage different learning processes, and these processes may be associated with different temporal constraints. We tested this hypothesis in a visuomotor adaptation task. Error feedback was indicated by the terminal position of a cursor, while outcome feedback was indicated by points. In separate groups of participants, the two feedback signals were presented immediately at the end of the movement, after a delay, or with just the error feedback delayed. Participants learned to counter the rotation in a similar manner regardless of feedback delay. However, the aftereffect, an indicator of implicit motor adaptation, was attenuated with delayed error feedback, consistent with the hypothesis that a different learning process supports performance under delay. We tested this by employing a task that dissociates the contribution of explicit strategies and implicit adaptation. We find that explicit aiming strategies contribute to the majority of the learning curve, regardless of delay; however, implicit learning, measured over the course of learning and by aftereffects, was significantly attenuated with delayed error-based feedback. These experiments offer new insight into the temporal constraints associated with different motor learning processes.

  1. Towards a U.S. Army Officer Corps Strategy for Success: Employing Talent

    DTIC Science & Technology

    2010-05-01

    OFFICER CORPS STRATEGY FOR SUCCESS: EMPLOYING TALENT INTRODUCTION In 1911, Frederick Winslow Taylor , a mechanical engineer, published The Principles of...and breadth of talent it needs, both now and in the future. ENDNOTES 1. Frederick Winslow Taylor , The Principles of Scientific Man- agement, New...York: Harper and Brothers, 1911, p. 19. 2. See “ Frederick Taylor and Scientific Management,” Net MBA Business Knowledge Center, available from

  2. Stress Response and Perinatal Reprogramming: Unraveling (Mal)adaptive Strategies

    PubMed Central

    Musazzi, Laura; Marrocco, Jordan

    2016-01-01

    Environmental stressors induce coping strategies in the majority of individuals. The stress response, involving the activation of the hypothalamic-pituitary-adrenocortical axis and the consequent release of corticosteroid hormones, is indeed aimed at promoting metabolic, functional, and behavioral adaptations. However, behavioral stress is also associated with fast and long-lasting neurochemical, structural, and behavioral changes, leading to long-term remodeling of glutamate transmission, and increased susceptibility to neuropsychiatric disorders. Of note, early-life events, both in utero and during the early postnatal life, trigger reprogramming of the stress response, which is often associated with loss of stress resilience and ensuing neurobehavioral (mal)adaptations. Indeed, adverse experiences in early life are known to induce long-term stress-related neuropsychiatric disorders in vulnerable individuals. Here, we discuss recent findings about stress remodeling of excitatory neurotransmission and brain morphology in animal models of behavioral stress. These changes are likely driven by epigenetic factors that lie at the core of the stress-response reprogramming in individuals with a history of perinatal stress. We propose that reprogramming mechanisms may underlie the reorganization of excitatory neurotransmission in the short- and long-term response to stressful stimuli. PMID:27057367

  3. Adaptive strategies in designing the simultaneous global drug development program.

    PubMed

    Yuan, Zhilong; Chen, Gang; Huang, Qin

    2016-01-01

    Many methods have been proposed to account for the potential impact of ethnic/regional factors when extrapolating results from multiregional clinical trials (MRCTs) to targeted ethnic (TE) patients, i.e., "bridging." Most of them either focused on TE patients in the MRCT (i.e., internal bridging) or a separate local clinical trial (LCT) (i.e., external bridging). Huang et al. (2012) integrated both bridging concepts in their method for the Simultaneous Global Drug Development Program (SGDDP) which designs both the MRCT and the LCT prospectively and combines patients in both trials by ethnic origin, i.e., TE vs. non-TE (NTE). The weighted Z test was used to combine information from TE and NTE patients to test with statistical rigor whether a new treatment is effective in the TE population. Practically, the MRCT is often completed before the LCT. Thus to increase the power for the SGDDP and/or obtain more informative data in TE patients, we may use the final results from the MRCT to re-evaluate initial assumptions (e.g., effect sizes, variances, weight), and modify the LCT accordingly. We discuss various adaptive strategies for the LCT such as sample size reassessment, population enrichment, endpoint change, and dose adjustment. As an example, we extend a popular adaptive design method to re-estimate the sample size for the LCT, and illustrate it for a normally distributed endpoint.

  4. Variability in thermal and phototactic preferences in Drosophila may reflect an adaptive bet‐hedging strategy

    PubMed Central

    Kain, Jamey S.; Zhang, Sarah; Akhund‐Zade, Jamilla; Samuel, Aravinthan D. T.; Klein, Mason; de Bivort, Benjamin L.

    2015-01-01

    Organisms use various strategies to cope with fluctuating environmental conditions. In diversified bet‐hedging, a single genotype exhibits phenotypic heterogeneity with the expectation that some individuals will survive transient selective pressures. To date, empirical evidence for bet‐hedging is scarce. Here, we observe that individual Drosophila melanogaster flies exhibit striking variation in light‐ and temperature‐preference behaviors. With a modeling approach that combines real world weather and climate data to simulate temperature preference‐dependent survival and reproduction, we find that a bet‐hedging strategy may underlie the observed interindividual behavioral diversity. Specifically, bet‐hedging outcompetes strategies in which individual thermal preferences are heritable. Animals employing bet‐hedging refrain from adapting to the coolness of spring with increased warm‐seeking that inevitably becomes counterproductive in the hot summer. This strategy is particularly valuable when mean seasonal temperatures are typical, or when there is considerable fluctuation in temperature within the season. The model predicts, and we experimentally verify, that the behaviors of individual flies are not heritable. Finally, we model the effects of historical weather data, climate change, and geographic seasonal variation on the optimal strategies underlying behavioral variation between individuals, characterizing the regimes in which bet‐hedging is advantageous. PMID:26531165

  5. Adaptive strategy for the statistical analysis of connectomes.

    PubMed

    Meskaldji, Djalel Eddine; Ottet, Marie-Christine; Cammoun, Leila; Hagmann, Patric; Meuli, Reto; Eliez, Stephan; Thiran, Jean Philippe; Morgenthaler, Stephan

    2011-01-01

    We study an adaptive statistical approach to analyze brain networks represented by brain connection matrices of interregional connectivity (connectomes). Our approach is at a middle level between a global analysis and single connections analysis by considering subnetworks of the global brain network. These subnetworks represent either the inter-connectivity between two brain anatomical regions or by the intra-connectivity within the same brain anatomical region. An appropriate summary statistic, that characterizes a meaningful feature of the subnetwork, is evaluated. Based on this summary statistic, a statistical test is performed to derive the corresponding p-value. The reformulation of the problem in this way reduces the number of statistical tests in an orderly fashion based on our understanding of the problem. Considering the global testing problem, the p-values are corrected to control the rate of false discoveries. Finally, the procedure is followed by a local investigation within the significant subnetworks. We contrast this strategy with the one based on the individual measures in terms of power. We show that this strategy has a great potential, in particular in cases where the subnetworks are well defined and the summary statistics are properly chosen. As an application example, we compare structural brain connection matrices of two groups of subjects with a 22q11.2 deletion syndrome, distinguished by their IQ scores.

  6. Sensor Web Dynamic Measurement Techniques and Adaptive Observing Strategies

    NASA Technical Reports Server (NTRS)

    Talabac, Stephen J.

    2004-01-01

    Sensor Web observing systems may have the potential to significantly improve our ability to monitor, understand, and predict the evolution of rapidly evolving, transient, or variable environmental features and events. This improvement will come about by integrating novel data collection techniques, new or improved instruments, emerging communications technologies and protocols, sensor mark-up languages, and interoperable planning and scheduling systems. In contrast to today's observing systems, "event-driven" sensor webs will synthesize real- or near-real time measurements and information from other platforms and then react by reconfiguring the platforms and instruments to invoke new measurement modes and adaptive observation strategies. Similarly, "model-driven" sensor webs will utilize environmental prediction models to initiate targeted sensor measurements or to use a new observing strategy. The sensor web concept contrasts with today's data collection techniques and observing system operations concepts where independent measurements are made by remote sensing and in situ platforms that do not share, and therefore cannot act upon, potentially useful complementary sensor measurement data and platform state information. This presentation describes NASA's view of event-driven and model-driven Sensor Webs and highlights several research and development activities at the Goddard Space Flight Center.

  7. A Brief Investigation of Adaptive Decision Feedback Equalization for Digital HF Links Employing PSK (Phase Shift Keying) Modulation.

    DTIC Science & Technology

    2014-09-26

    INVESTIGATION OF ADAPTIVE DECISION FEEDBACK EQUALIZATION FOR DIGITAL HF LINKS EMPLOYING PSKK MODULATION B.E. Sawyer Mission Research Corporation P.O. Drawer 719...Rot FEEDBACK EQUAL Z FOR IGITAL HF LINKS TcnclRpr PERFORMING ORG. REPORT NUMBERMRC-R-801- 7, AUTHORf,, 8. CONTRACT OR GRANT NUMBER(-) Blair E...C’!, -i, e -n rev r- , -de if necessary and identify by block number) PSK Receiver Mitigation Adaptive Equalization Decision Feedback Equalization HF

  8. Adapting global influenza management strategies to address emerging viruses.

    PubMed

    Noah, Diana L; Noah, James W

    2013-07-15

    Death by respiratory complications from influenza infections continues to be a major global health concern. Antiviral drugs are widely available for therapy and prophylaxis, but viral mutations have resulted in resistance that threatens to reduce the long-term utility of approved antivirals. Vaccination is the best method for controlling influenza, but vaccine strategies are blunted by virus antigenic drift and shift. Genetic shift in particular has led to four pandemics in the last century, which have prompted the development of efficient global surveillance and vaccination programs. Although the influenza pandemic of 2009 emphasized the need for the rapid standardization of global surveillance methods and the preparation and dissemination of global assay standards for improved reporting and diagnostic tools, outbreaks of novel influenza strains continue to occur, and current efforts must be enhanced by aggressive public education programs to promote increased vaccination rates in the global population. Recently, a novel H7N9 avian influenza virus with potential to become a pandemic strain emerged in China and was transmitted from animals to humans with a demonstrated >20% mortality rate. Sporadic outbreaks of highly lethal avian virus strains have already increased public awareness and altered annual vaccine production strategies to prevent the natural adaption of this virus to human-to-human transmission. Additional strategies for combating influenza include advancement of new antivirals for unexploited viral or host cellular targets; novel adjuvants and alternate vaccine delivery systems; and development of universal protein, DNA, or multivalent vaccines designed to increase immune responsiveness and enhance public health response times.

  9. Microevolution from shock to adaptation revealed strategies improving ethanol tolerance and production in Thermoanaerobacter

    PubMed Central

    2013-01-01

    Introduction The molecular links between shock-response and adaptation remain poorly understood, particularly for extremophiles. This has hindered rational engineering of solvent tolerance and correlated traits (e.g., productivity) in extremophiles. To untangle such molecular links, here we established a model that tracked the microevolution from shock to adaptation in thermophilic bacteria. Method Temporal dynamics of genomes and transcriptomes was tracked for Thermoanaerobacter sp. X514 which under increasing exogenous ethanol evolved from ethanol-sensitive wild-type (Strain X) to tolerance of 2%- (XI) and eventually 6%-ethanol (XII). Based on the reconstructed transcriptional network underlying stress tolerance, genetic engineering was employed to improve ethanol tolerance and production in Thermoanaerobacter. Results The spontaneous genome mutation rate (μg) of Thermoanaerobacter sp. X514, calculated at 0.045, suggested a higher mutation rate in thermophile than previously thought. Transcriptomic comparison revealed that shock-response and adaptation were distinct in nature, whereas the transcriptomes of XII resembled those of the extendedly shocked X. To respond to ethanol shock, X employed fructose-specific phosphotransferase system (PTS), Arginine Deiminase (ADI) pathway, alcohol dehydrogenase (Adh) and a distinct mechanism of V-type ATPase. As an adaptation to exogenous ethanol, XI mobilized resistance-nodulation-cell division (RND) efflux system and Adh, whereas XII, which produced higher ethanol than XI, employed ECF-type ϭ24, an alcohol catabolism operon and phase-specific heat-shock proteins (Hsps), modulated hexose/pentose-transport operon structure and reinforced membrane rigidity. Exploiting these findings, we further showed that ethanol productivity and tolerance can be improved simultaneously by overexpressing adh or ϭ24 in X. Conclusion Our work revealed thermophilic-bacteria specific features of adaptive evolution and demonstrated a rational

  10. A Functional Approach To Uncover the Low-Temperature Adaptation Strategies of the Archaeon Methanosarcina barkeri

    PubMed Central

    McCay, Paul; Fuszard, Matthew; Botting, Catherine H.; Abram, Florence; O'Flaherty, Vincent

    2013-01-01

    Low-temperature anaerobic digestion (LTAD) technology is underpinned by a diverse microbial community. The methanogenic archaea represent a key functional group in these consortia, undertaking CO2 reduction as well as acetate and methylated C1 metabolism with subsequent biogas (40 to 60% CH4 and 30 to 50% CO2) formation. However, the cold adaptation strategies, which allow methanogens to function efficiently in LTAD, remain unclear. Here, a pure-culture proteomic approach was employed to study the functional characteristics of Methanosarcina barkeri (optimum growth temperature, 37°C), which has been detected in LTAD bioreactors. Two experimental approaches were undertaken. The first approach aimed to characterize a low-temperature shock response (LTSR) of M. barkeri DSMZ 800T grown at 37°C with a temperature drop to 15°C, while the second experimental approach aimed to examine the low-temperature adaptation strategies (LTAS) of the same strain when it was grown at 15°C. The latter experiment employed cell viability and growth measurements (optical density at 600 nm [OD600]), which directly compared M. barkeri cells grown at 15°C with those grown at 37°C. During the LTSR experiment, a total of 127 proteins were detected in 37°C and 15°C samples, with 20 proteins differentially expressed with respect to temperature, while in the LTAS experiment 39% of proteins identified were differentially expressed between phases of growth. Functional categories included methanogenesis, cellular information processing, and chaperones. By applying a polyphasic approach (proteomics and growth studies), insights into the low-temperature adaptation capacity of this mesophilically characterized methanogen were obtained which suggest that the metabolically diverse Methanosarcinaceae could be functionally relevant for LTAD systems. PMID:23645201

  11. Strategies for state-wide implementation of supported employment: the Johnson & Johnson-Dartmouth Community Mental Health Program.

    PubMed

    Becker, Deborah R; Lynde, David; Swanson, Sarah J

    2008-01-01

    This paper reviews key strategies for implementing evidence-based supported employment statewide. The Johnson & Johnson-Dartmouth Community Mental Health Program collaborates with 9 states and the District of Columbia to implement supported employment in a sustainable way. Technical assistance and teambased training help agencies develop high fidelity programs that result in good employment outcomes for people with severe mental illness.

  12. Systematic review of employer-sponsored wellness strategies and their economic and health-related outcomes.

    PubMed

    Kaspin, Lisa C; Gorman, Kathleen M; Miller, Ross M

    2013-02-01

    This review determines the characteristics and health-related and economic outcomes of employer-sponsored wellness programs and identifies possible reasons for their success. PubMed, ABI/Inform, and Business Source Premier databases, and Corporate Wellness Magazine were searched. English-language articles published from 2005 to 2011 that reported characteristics of employer-sponsored wellness programs and their impact on health-related and economic outcomes among US employees were accepted. Data were abstracted, synthesized, and interpreted. Twenty references were accepted. Wellness interventions were classified into health assessments, lifestyle management, and behavioral health. Improved economic outcomes were reported (health care costs, return on investment, absenteeism, productivity, workers' compensation, utilization) as well as decreased health risks. Programs associated with favorable outcomes had several characteristics in common. First, the corporate culture encouraged wellness to improve employees' lives, not only to reduce costs. Second, employees and leadership were strongly motivated to support the wellness programs and to improve their health in general. Third, employees were motivated by a participation-friendly corporate policy and physical environment. Fourth, successful programs adapted to the changing needs of the employees. Fifth, community health organizations provided support, education, and treatment. Sixth, successful wellness programs utilized technology to facilitate health risk assessments and wellness education. Improved health-related and economic outcomes were associated with employer-sponsored wellness programs. Companies with successful programs tended to include wellness as part of their corporate culture and supported employee participation in several key ways.

  13. Floral thermogenesis: An adaptive strategy of pollination biology in Magnoliaceae.

    PubMed

    Wang, Ruohan; Zhang, Zhixiang

    2015-01-01

    Floral thermogenesis plays a crucial role in pollination biology, especially in plant-pollinator interactions. We have recently explored how thermogenesis is related to pollinator activity and odour release in Magnolia sprengeri. By analyzing flower temperatures, emission of volatiles, and insect visitation, we found that floral blends released during pistillate and staminate stages were similar and coincided with sap beetle visitation. Thus, odour mimicry of staminate-stage flowers may occur during the pistillate stage and may be an adaptive strategy of Magnolia species to attract pollinators during both stages, ensuring successful pollination. In addition to the biological significance of floral thermogenesis in Magnolia species, we explored the underlying regulatory mechanisms via profiling miRNA expression in M. denudata flowers during thermogenic and non-thermogenic stages. We identified 17 miRNAs that may play regulatory roles in floral thermogenesis. Functional annotation of their target genes indicated that these miRNAs regulate floral thermogenesis by influencing cellular respiration and light reactions. These findings increase our understanding of plant-pollinator interactions and the regulatory mechanisms in thermogenic plants.

  14. Strategies employed by upper secondary students for overcoming or exploiting conditions affecting accessibility of applications tasks

    NASA Astrophysics Data System (ADS)

    Stillman, Gloria

    2004-02-01

    A cognitive/metacognitive framework is presented for analysing applications tasks and responses to these. Conditions facilitating or impeding access to such tasks at the upper secondary level were identified using qualitative data analysis techniques within this framework. Strategies employed in exploiting, or overcoming these conditions were identified. A well-developed repertoire of cognitive and metacognitive strategies together with a rich store of mathematical knowledge, real-world knowledge and experiences, and comprehension skills facilitated access. This was enhanced by metacognitive knowledge encouraging student engagement with the task and by students imagining they were in the task situation. Once moderate skill had been achieved in accessing these applications, coordination and integration of multiple representations, further cues, and mathematical processes and procedures became critical.

  15. Adaptive Management as an Effective Strategy: Interdisciplinary Perceptions for Natural Resources Management

    NASA Astrophysics Data System (ADS)

    Dreiss, Lindsay M.; Hessenauer, Jan-Michael; Nathan, Lucas R.; O'Connor, Kelly M.; Liberati, Marjorie R.; Kloster, Danielle P.; Barclay, Janet R.; Vokoun, Jason C.; Morzillo, Anita T.

    2017-02-01

    Adaptive management is a well-established approach to managing natural resources, but there is little evidence demonstrating effectiveness of adaptive management over traditional management techniques. Peer-reviewed literature attempts to draw conclusions about adaptive management effectiveness using social perceptions, but those studies are largely restricted to employees of US federal organizations. To gain a more comprehensive insight into perceived adaptive management effectiveness, this study aimed to broaden the suite of disciplines, professional affiliations, and geographic backgrounds represented by both practitioners and scholars. A questionnaire contained a series of questions concerning factors that lead to or inhibit effective management, followed by another set of questions focused on adaptive management. Using a continuum representing strategies of both adaptive management and traditional management, respondents selected those strategies that they perceived as being effective. Overall, characteristics (i.e., strategies, stakeholders, and barriers) identified by respondents as contributing to effective management closely aligned with adaptive management. Responses were correlated to the type of adaptive management experience rather than an individual's discipline, occupational, or regional affiliation. In particular, perceptions of characteristics contributing to adaptive management effectiveness varied between respondents who identified as adaptive management scholars (i.e., no implementation experience) and adaptive management practitioners. Together, these results supported two concepts that make adaptive management effective: practitioners emphasized adaptive management's value as a long-term approach and scholars noted the importance of stakeholder involvement. Even so, more communication between practitioners and scholars regarding adaptive management effectiveness could promote interdisciplinary learning and problem solving for improved

  16. Sucessful Strategies for Empowering Students to Get High Paying and Rewarding Employment in Industry (and elsewhere)

    NASA Astrophysics Data System (ADS)

    Schwartz, Brian

    2002-03-01

    Physics students entering graduate school rarely think about (and more importantly take actions) concerning developing employment options and wider marketable skills while studying towards their Ph.D. degree. It is only as they are about to graduate that they begin thinking about the job market and start preparing a resume and take some initial steps in their job search. I call this the “series process” towards obtaining employment; that is, first go to graduate school, finish the Ph.D. program and then initiate a serious job search. A far better approach with a much higher success and satisfaction rate is the “parallel process” in which the graduate student takes proactive career steps throughout graduate studies. In this approach, the students treat their future career seriously and as a research and development project in parallel to (and as important as) thesis research. The proactive student sharpens such career management skills as resume and vita preparation, assesses and develops transferable skills, strengthens communication skills (especially oral), practices interviewing skills and most importantly continually and purposefully expands a network to colleagues and potential employers. Through a grant from National Science Foundation the author has operated a program at The Graduate Center to assists Ph.D. students in developing and enhancing their career management skills. We describe proven techniques that, if developed throughout the students’ graduate studies, greatly enhance their employment opportunities. We will focus on strategies that can (and should be used) to identify, qualify for and obtain employment in the industrial sector.

  17. Adaptive strategies of Yersinia pestis to persist during inter-epizootic and epizootic periods

    PubMed Central

    Eisen, Rebecca J.; Gage, Kenneth L.

    2009-01-01

    Plague is a flea-borne zoonotic bacterial disease caused by Yersinia pestis. It has caused three historical pandemics, including the Black Death which killed nearly a third of Europe's population in the 14th century. In modern times, plague epizootics can extirpate entire susceptible wildlife populations and then disappear for long time periods. Understanding how Y. pestis is maintained during inter-epizootic periods and the factors responsible for transitioning to epizootics is important for preventing and controlling pathogen transmission and ultimately reducing the burden of human disease. In this review, we focus primarily on plague in North American foci and discuss the potential adaptive strategies Y. pestis might employ to ensure not only its survival during inter-epizootic periods but also the rapid epizootic spread and invasion of new territories that are so characteristic of plague and have resulted in major pandemics and establishment of plague foci throughout much of the world. PMID:18803931

  18. Adaptation Strategies of Individuals With Anterior Cruciate Ligament Reconstruction

    PubMed Central

    Roper, Jaimie A.; Terza, Matthew J.; Tillman, Mark D.; Hass, Chris J.

    2016-01-01

    Background: Despite the strong implications for rehabilitation design, the capability of individuals with anterior cruciate ligament reconstruction (ACLR) to adapt and store novel gait patterns have not been well studied. Purpose: To investigate how reconstructive surgery may affect the ability to adapt and store novel gait patterns in persons with ACLR while walking on a split-belt treadmill. Study Design: Controlled laboratory study. Methods: Gait adaptation was compared between 20 participants with ACLR and 20 healthy controls during split-belt treadmill walking. Gait adaptation was assessed in slow- and fast-adapting parameters by (1) the magnitude of symmetry during late adaptation and (2) the amount of the asymmetry during de-adaptation. Results: Healthy individuals adapted a new walking pattern and stored the new walking pattern equally in both the dominant and nondominant limbs. Conversely, individuals with ACLR displayed impairments in both slow-adapting and fast-adapting derived gait adaptation and significant differences in behavior between the reconstructed and uninjured limb. Conclusion: While surgical reconstruction and physical therapy are aimed at improving mechanical stability to the knee, the study data suggest that fundamental features of motor control remain altered. After ACLR, participants display an altered ability to learn and store functional gait patterns. PMID:26894200

  19. An adaptive regularization parameter choice strategy for multispectral bioluminescence tomography

    SciTech Connect

    Feng Jinchao; Qin Chenghu; Jia Kebin; Han Dong; Liu Kai; Zhu Shouping; Yang Xin; Tian Jie

    2011-11-15

    Purpose: Bioluminescence tomography (BLT) provides an effective tool for monitoring physiological and pathological activities in vivo. However, the measured data in bioluminescence imaging are corrupted by noise. Therefore, regularization methods are commonly used to find a regularized solution. Nevertheless, for the quality of the reconstructed bioluminescent source obtained by regularization methods, the choice of the regularization parameters is crucial. To date, the selection of regularization parameters remains challenging. With regards to the above problems, the authors proposed a BLT reconstruction algorithm with an adaptive parameter choice rule. Methods: The proposed reconstruction algorithm uses a diffusion equation for modeling the bioluminescent photon transport. The diffusion equation is solved with a finite element method. Computed tomography (CT) images provide anatomical information regarding the geometry of the small animal and its internal organs. To reduce the ill-posedness of BLT, spectral information and the optimal permissible source region are employed. Then, the relationship between the unknown source distribution and multiview and multispectral boundary measurements is established based on the finite element method and the optimal permissible source region. Since the measured data are noisy, the BLT reconstruction is formulated as l{sub 2} data fidelity and a general regularization term. When choosing the regularization parameters for BLT, an efficient model function approach is proposed, which does not require knowledge of the noise level. This approach only requests the computation of the residual and regularized solution norm. With this knowledge, we construct the model function to approximate the objective function, and the regularization parameter is updated iteratively. Results: First, the micro-CT based mouse phantom was used for simulation verification. Simulation experiments were used to illustrate why multispectral data were used

  20. The evolutionary strategies of plant defenses have a dynamic impact on the adaptations and interactions of vectors and pathogens.

    PubMed

    Huot, Ordom Brian; Nachappa, Punya; Tamborindeguy, Cecilia

    2013-06-01

    Plants have evolved and diversified to reduce the damages imposed by infectious pathogens and herbivorous insects. Living in a sedentary lifestyle, plants are constantly adapting to their environment. They employ various strategies to increase performance and fitness. Thus, plants developed cost-effective strategies to defend against specific insects and pathogens. Plant defense, however, imposes selective pressure on insects and pathogens. This selective pressure provides incentives for pathogens and insects to diversify and develop strategies to counter plant defense. This results in an evolutionary arms race among plants, pathogens and insects. The ever-changing adaptations and physiological alterations among these organisms make studying plant-vector-pathogen interactions a challenging and fascinating field. Studying plant defense and plant protection requires knowledge of the relationship among organisms and the adaptive strategies each organism utilize. Therefore, this review focuses on the integral parts of plant-vector-pathogen interactions in order to understand the factors that affect plant defense and disease development. The review addresses plant-vector-pathogen co-evolution, plant defense strategies, specificity of plant defenses and plant-vector-pathogen interactions. Improving the comprehension of these factors will provide a multi-dimensional perspective for the future research in pest and disease management.

  1. Land Use Adaptation Strategies Analysis in Landslide Risk Region

    NASA Astrophysics Data System (ADS)

    Lin, Yu-Ching; Chang, Chin-Hsin; Chen, Ying-Tung

    2013-04-01

    In order to respond to the impact of climate and environmental change on Taiwanese mountain region, this study used GTZ (2004) Risk analysis guidelines to assess the landslide risk for 178 Taiwanese mountain towns. This study used 7 indicators to assess landslide risk, which are rainfall distribution, natural environment vulnerability (e.g., rainfall threshold criterion for debris flow, historical disaster frequency, landslide ratio, and road density), physicality vulnerability (e.g., population density) and socio-economic vulnerability (e.g., population with higher education, death rate and income). The landslide risk map can be obtained by multiplying 7 indicators together and ranking the product. The map had 5 risk ranges, and towns within the range of 4 to 5, which are high landslide risk regions, and have high priority in reducing risk. This study collected the regions with high landslide risk regions and analyzed the difference after Typhoon Morakot (2009). The spatial distribution showed that after significant environmental damage high landslide risk regions moved from central to south Taiwan. The changeable pattern of risk regions pointed out the necessity of updating the risk map periodically. Based on the landslide risk map and the land use investigation data which was provided by the National Land Surveying and Mapping Center in 2007, this study calculated the size of the land use area with landslide disaster risk. According to the above results and discussion, this study can be used to suggest appropriate land use adaptation strategies provided for reducing landslide risk under the impact of climate and environmental change.

  2. Strategies for improving adaptation practice in developing countries

    NASA Astrophysics Data System (ADS)

    Conway, Declan; Mustelin, Johanna

    2014-05-01

    The international community's support for adaptation in developing countries has proliferated through numerous complementary funding mechanisms. A range of serious practical issues are emerging, however, as adaptation moves from theory and international negotiation to implementation. We identify three areas deserving greater scrutiny: in-country priorities, entry points and delivery systems, and provide recommendations for improving adaptation practice. These concerns, if not addressed, have the potential to hamper attempts at effective delivery and to increase the vulnerability of intended beneficiaries of the adaptation agenda.

  3. Dual-thread parallel control strategy for ophthalmic adaptive optics.

    PubMed

    Yu, Yongxin; Zhang, Yuhua

    To improve ophthalmic adaptive optics speed and compensate for ocular wavefront aberration of high temporal frequency, the adaptive optics wavefront correction has been implemented with a control scheme including 2 parallel threads; one is dedicated to wavefront detection and the other conducts wavefront reconstruction and compensation. With a custom Shack-Hartmann wavefront sensor that measures the ocular wave aberration with 193 subapertures across the pupil, adaptive optics has achieved a closed loop updating frequency up to 110 Hz, and demonstrated robust compensation for ocular wave aberration up to 50 Hz in an adaptive optics scanning laser ophthalmoscope.

  4. Identity Transformation During the Transition to Parenthood Among Same-Sex Couples: An Ecological, Stress-Strategy-Adaptation Perspective

    PubMed Central

    Cao, Hongjian; Mills-Koonce, W. Roger; Wood, Claire; Fine, Mark A.

    2016-01-01

    This article reviews the current research on the potential stressors associated with identity transformation experienced by same-sex couples during the transition to parenthood and the coping strategies they employ. By integrating disparate findings into an ecological, stress-strategy-adaptation framework, we demonstrate that the identity transformation experiences among same-sex couples during the transition to parenthood (a) involve various adaptive processes of navigating different stressors via their human agency within multiple nested contexts; (b) are products of the intersections of individual characteristics, relational dynamics, LGBT community culture, and heterosexual sociostructural norms; and (c) are complicated by social contextual factors such as social class, race/ethnicity, family structure, and the sociocultural environment associated with geographic location. Last, several avenues for future inquiry are suggested. PMID:27458482

  5. Identity Transformation During the Transition to Parenthood Among Same-Sex Couples: An Ecological, Stress-Strategy-Adaptation Perspective.

    PubMed

    Cao, Hongjian; Mills-Koonce, W Roger; Wood, Claire; Fine, Mark A

    2016-03-01

    This article reviews the current research on the potential stressors associated with identity transformation experienced by same-sex couples during the transition to parenthood and the coping strategies they employ. By integrating disparate findings into an ecological, stress-strategy-adaptation framework, we demonstrate that the identity transformation experiences among same-sex couples during the transition to parenthood (a) involve various adaptive processes of navigating different stressors via their human agency within multiple nested contexts; (b) are products of the intersections of individual characteristics, relational dynamics, LGBT community culture, and heterosexual sociostructural norms; and (c) are complicated by social contextual factors such as social class, race/ethnicity, family structure, and the sociocultural environment associated with geographic location. Last, several avenues for future inquiry are suggested.

  6. Adaptive Instructional Strategies for Teaching Rules in Mathematics.

    ERIC Educational Resources Information Center

    Ross, Steven M.; Rakow, Ernest A.

    1982-01-01

    Describes research on an adaptation approach designed to extend the aptitude treatment interaction (ATI) concept by applying instructional variations to individuals as opposed to groups within the context of an introductory mathematics lesson adapted from the beginning module in an undergraduate statistics course. A 17-item reference list is…

  7. Management Strategies for Complex Adaptive Systems: Sensemaking, Learning, and Improvisation

    ERIC Educational Resources Information Center

    McDaniel, Reuben R., Jr.

    2007-01-01

    Misspecification of the nature of organizations may be a major reason for difficulty in achieving performance improvement. Organizations are often viewed as machine-like, but complexity science suggests that organizations should be viewed as complex adaptive systems. I identify the characteristics of complex adaptive systems and give examples of…

  8. American Poverty: The Role of Education, Training and Employment Strategies in the New Anti-Poverty Struggle.

    ERIC Educational Resources Information Center

    Evaluation Forum, 1994

    1994-01-01

    This document, which is directed toward employment and training professionals analyzing/researching policies and issues in education, occupational training, work and welfare, and economic development, contains feature articles, commentary, interviews, and other information on the role of education, training, and employment strategies in reducing…

  9. Employment Success of Handicapped Individuals via Three Transition Strategies. Final Project Report, September 1, 1984-August 30, 1985.

    ERIC Educational Resources Information Center

    Campbell, Pamela

    Through an examination of the transition process used by a representative sample of successfully employed handicapped individuals in Florida, specific transition strategies and the degree to which they were used were identified. Fifty successfully employed handicapped individuals participated. The high school experience was cited as essential in…

  10. 77 FR 2996 - National Fish, Wildlife, and Plants Climate Adaptation Strategy

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-20

    ... natural systems provide, in a changing climate. In addition to this request for written comments, several..., Wildlife, and Plants Climate Adaptation Strategy (Strategy). The adverse impacts of climate change... wildlife and society against the effects of climate change. When finalized, this draft Strategy...

  11. Turnaround Management Strategies: The Adaptive Model and the Constructive Model. ASHE 1983 Annual Meeting Paper.

    ERIC Educational Resources Information Center

    Chaffee, Ellen E.

    The use of two management strategies by 14 liberal arts and comprehensive colleges attempting to recover from serious financial decline during 1973-1976 were studied. The adaptive model of strategy, based on resource dependence, involves managing demands in order to satisfy critical-resource providers. The constructive model of strategy, based on…

  12. The influence of context on the implementation of adaptive emotion regulation strategies.

    PubMed

    Aldao, Amelia; Nolen-Hoeksema, Susan

    2012-08-01

    Putatively adaptive emotion regulation strategies (e.g., acceptance, problem solving, reappraisal) show weaker associations with psychopathology than putatively maladaptive strategies (e.g., avoidance, self-criticism, hiding expression, suppression of experience, worry, rumination). This is puzzling, given the central role that adaptive strategies play in a wide range of psychotherapeutic approaches. We explored this asymmetry by examining the effects of context (i.e., emotion intensity, type of emotion, social vs. academic circumstances) on the implementation of adaptive and maladaptive strategies. We asked 111 participants to describe 8 emotion-eliciting situations and identify which strategies they used in order to regulate their affect. We found support for a contextual model of emotion regulation, in which adaptive strategies were implemented with more cross-situational variability than maladaptive strategies. In addition, the variability in implementation of two adaptive strategies (acceptance, problem solving) predicted lower levels of psychopathology, suggesting that flexible implementation of such strategies in line with contextual demands is associated with better mental health. We discuss these findings by underscoring the importance of adopting a functional approach to the delineation of contextual factors that influence the implementation of emotion regulation strategies.

  13. Cowpox virus employs a two-pronged strategy to outflank MHCI antigen presentation.

    PubMed

    McCoy, William H; Wang, Xiaoli; Yokoyama, Wayne M; Hansen, Ted H; Fremont, Daved H

    2013-09-01

    Smallpox decimated humanity for thousands of years before being eradicated by vaccination, a success facilitated by the fact that humans are the only host of variola virus. In contrast, other orthopoxviruses such as cowpox virus can infect a variety of mammalian species, although its dominant reservoir appears to be rodents. This difference in host specificity suggests that cowpox may have developed promiscuous immune evasion strategies to facilitate zoonosis. Recent experiments have established that cowpox can disrupt MHCI antigen presentation during viral infection of both human and murine cells, a process enabled by two unique proteins, CPXV012 and CPXV203. While CPXV012 inhibits antigenic peptide transport from the cytosol to the ER, CPXV203 blocks MHCI trafficking to the cell surface by exploiting the KDEL-receptor recycling pathway. Our recent investigations of CPXV203 reveal that it binds a diverse array of classical and non-classical MHCI proteins with dramatically increased affinities at the lower pH of the Golgi relative to the ER, thereby providing mechanistic insight into how it works synergistically with KDEL receptors to block MHCI surface expression. The strategy used by cowpox to both limit peptide supply and disrupt trafficking of fully assembled MHCI acts as a dual-edged sword that effectively disables adaptive immune surveillance of infected cells.

  14. A Qualitative Account of the Nature and Use of Self-Regulated Learning (SRL) Strategies Employed by University Students

    ERIC Educational Resources Information Center

    Alvi, Effat; Iqbal, Zafar; Masood, Fatima; Batool, Tooba

    2016-01-01

    Students' conceptions of how they initiate, plan, implement and monitor self-regulated learning (SRL) strategies have practical implications for teaching and learning. This study explores the nature and use of SRL strategies employed by university students as it occurs in naturalistic settings, for example, studying in non-classroom environments.…

  15. Language Learning Strategies Employed by Chinese English-Major Pre-Service Teachers in Relation to Gender and Personality Types

    ERIC Educational Resources Information Center

    Zhou, Chaoying; Intaraprasert, Channarong

    2015-01-01

    This study was intended to investigate the use of language learning strategy employed by English-major pre-service teachers in Midwest China in relation to their gender and personality types. The modified Strategy Inventory for Language Learning (SILL) and adopted personality type inventory were used to collect the data. ANOVA and Chi-square tests…

  16. The Impact of Employing Brainstorming Strategy on Improving Writing Performance of English Major Students at Balqa Applied University in Jordan

    ERIC Educational Resources Information Center

    Amoush, Kholoud Hussein

    2015-01-01

    The study aimed at identifying the impact of employing brainstorming strategy on improving writing performance of English Major Students at Balqa Applied University in Jordan. The sample of the study which consisted of 80 male and female university students was distributed into two groups; experimental (taught by brainstorming strategy) and…

  17. Understanding the Clausius-Clapeyron Equation by Employing an Easily Adaptable Pressure Cooker

    ERIC Educational Resources Information Center

    Galleano, Monica; Boveris, Alberto; Puntarulo, Susana

    2008-01-01

    This article describes a simple and inexpensive laboratory exercise developed to understand the effect of pressure on phase equilibrium as described by the Clausius-Clapeyron equation. The only piece of equipment required is a pressure cooker adapted with a pressure gauge and a thermometer in the lid, allowing the measurement of the pressure and…

  18. When Easy Comes Hard: The Development of Adaptive Strategy Selection

    ERIC Educational Resources Information Center

    Mata, Rui; von Helversen, Bettina; Rieskamp, Jorg

    2011-01-01

    Can children learn to select the right strategy for a given problem? In one experiment, 9- to 10-year-olds (N = 50), 11- to 12-year-olds (N = 50), and adults (N = 50) made probabilistic inferences. Participants encountered environments favoring either an information-intensive strategy that integrates all available information or an…

  19. Tools, Equipment, and Machinery Adapted for the Vocational Education and Employment of Handicapped People.

    ERIC Educational Resources Information Center

    Gugerty, John, Comp.; And Others

    Intended to assist in the vocational education and employment of individuals who are handicapped, this catalog contains descriptions and illustrations of modified tools, equipment, and machinery for use in 38 areas. These use areas are arts, assembly, assessment, automobile repair, benchwork, communication, computer processing, cosmetology,…

  20. Strategy for adaptive process control for a column flotation unit

    SciTech Connect

    Karr, C.L.; Ferguson, C.R.

    1994-12-31

    Researchers at the U.S. Bureau of Mines (USBM) have developed adaptive process control systems in which genetic algorithms (GAs) are used to augment fuzzy logic controllers (FLCs). Together, GAs and FLCs possess the capabilities necessary to produce powerful, efficient, and robust adaptive control systems. To perform efficiently, such control systems require a control element to manipulate the problem environment, an analysis element to recognize changes in the problem environment, and a learning element to adjust to the changes in the problem environment. In this paper, the details of an ongoing research effort to develop and implement an adaptive process control system for a column flotation unit are discussed. Column flotation units are used extensively in the mineral processing industry to recover valuable minerals from their ores.

  1. Control Reallocation Strategies for Damage Adaptation in Transport Class Aircraft

    NASA Technical Reports Server (NTRS)

    Gundy-Burlet, Karen; Krishnakumar, K.; Limes, Greg; Bryant, Don

    2003-01-01

    This paper examines the feasibility, potential benefits and implementation issues associated with retrofitting a neural-adaptive flight control system (NFCS) to existing transport aircraft, including both cable/hydraulic and fly-by-wire configurations. NFCS uses a neural network based direct adaptive control approach for applying alternate sources of control authority in the presence of damage or failures in order to achieve desired flight control performance. Neural networks are used to provide consistent handling qualities across flight conditions, adapt to changes in aircraft dynamics and to make the controller easy to apply when implemented on different aircraft. Full-motion piloted simulation studies were performed on two different transport models: the Boeing 747-400 and the Boeing C-17. Subjects included NASA, Air Force and commercial airline pilots. Results demonstrate the potential for improving handing qualities and significantly increased survivability rates under various simulated failure conditions.

  2. Competition and time-dependent behavior in spatial iterated prisoner’s dilemma incorporating adaptive zero-determinant strategies

    NASA Astrophysics Data System (ADS)

    Li, Yong; Xu, Chen; Liu, Jie; Hui, Pak Ming

    2016-10-01

    We propose and study the competitiveness of a class of adaptive zero-determinant strategies (ZDSs) in a population with spatial structure against four classic strategies in iterated prisoner’s dilemma. Besides strategy updating via a probabilistic mechanism by imitating the strategy of a better performing opponent, players using the ZDSs can also adapt their strategies to take advantage of their local competing environment with another probability. The adapted ZDSs could be extortionate-like to avoid being continually cheated by defectors or to take advantage of unconditional cooperators. The adapted ZDSs could also be a compliance strategy so as to cooperate with the conditionally cooperative players. This flexibility makes adaptive ZDSs more competitive than nonadaptive ZDSs. Results show that adaptive ZDSs can either dominate over other strategies or at least coexist with them when the ZDSs are allowed to adapt more readily than to imitate other strategies. The effectiveness of the adaptive ZDSs relies on how fast they can adapt to the competing environment before they are replaced by other strategies. The adaptive ZDSs generally work well as they could adapt gradually and make use of other strategies for suppressing their enemies. When adaptation happens more readily than imitation for the ZDSs, they outperform other strategies over a wide range of cost-to-benefit ratios.

  3. On Adaptive Extended Compatibility Changing Type of Product Design Strategy

    NASA Astrophysics Data System (ADS)

    Wenwen, Jiang; Zhibin, Xie

    The article uses research ways of Enterprise localization and enterprise's development course to research strategy of company's product design and development. It announces at different stages for development, different kinds of enterprises will adopt product design and development policies of different modes. It also announces close causality between development course of company and central technology and product. The result indicated enterprises in leading position in market, technology and brand adopt pioneer strategy type of product research and development. These enterprise relying on the large-scale leading enterprise offering a complete set service adopts the passively duplicating type tactic of product research and development. Some enterprise in part of advantage in technology, market, management or brand adopt following up strategy of product research and development. The enterprises with relative advantage position adopt the strategy of technology applied taking optimizing services as centre in product research and development in fields of brand culture and market service.

  4. Some Properties of a Bayesian Adaptive Ability Testing Strategy.

    ERIC Educational Resources Information Center

    McBride, James R.; Weiss, David J.

    Four monte carlo simulation studies of Owen's Bayesian sequential procedure for adaptive mental testing were conducted. Whereas previous simulation studies of this procedure have concentrated on evaluating it in terms of the correlation of its test scores with simulated ability in a normal population, these four studies explored a number of…

  5. Identification of novel B-Raf(V600E) inhibitors employing FBDD strategy.

    PubMed

    Wang, Peng-Fei; Qiu, Han-Yue; Wang, Ze-Feng; Zhang, Yong-Jiao; Wang, Zhong-Chang; Li, Dong-Dong; Zhu, Hai-Liang

    2017-05-15

    B-Raf kinase is the key point in a main branch of mitogen-activated protein kinase pathways and some of its mutations, such as the V600E mutation, lead to the persistent activation of ERK signaling and the trigger of severe diseases, including melanoma and other somatic cancers. Several potent drugs have been approved to treat B-Raf-related tumors, however, cases of resistance and relapse have been reported universally. Hence, differential scaffolds are in need to alleviate the scarcity of drugs and benefit the therapy of B-Raf-mutant cancers. Herein we report our recent work on the construction of novel B-Raf(V600E) inhibitors employing fragment-based drug design strategy. In this research, we decomposed known inhibitors to fragments and rebuilt new candidates using these blocks according to the evaluation of their potential. Lead compounds were synthesized after selection by means of virtual screening and molecular dynamics validation. Afterwards, we tested the pharmacological efficiency of these entities both in vitro and in vivo utilizing A375 xenograft model. The results favored our rational design intention and hinted this new kind of inhibitors might be helpful in the further explorations of potent agents.

  6. Experimental Studies on Model Reference Adaptive Control with Integral Action Employing a Rotary Encoder and Tachometer Sensors

    PubMed Central

    Wu, Guo-Qiang; Wu, Shu-Nan; Bai, Yu-Guang; Liu, Lei

    2013-01-01

    In this paper, an adaptive law with an integral action is designed and implemented on a DC motor by employing a rotary encoder and tachometer sensors. The stability is proved by using the Lyapunov function. The tracking errors asymptotically converge to zero according to the Barbalat lemma. The tracking performance is specified by a reference model, the convergence rate of Lyapunov function is specified by the matrix Q and the control action and the state weighting are restricted by the matrix Γ. The experimental results demonstrate the effectiveness of the proposed control. The maximum errors of the position and velocity with the integral action are reduced from 0.4 V and 1.5 V to 0.2 V and 0.4 V, respectively. The adaptive control with the integral action gives satisfactory performance, even when it suffers from input disturbance. PMID:23575034

  7. Experimental studies on model reference adaptive control with integral action employing a rotary encoder and tachometer sensors.

    PubMed

    Wu, Guo-Qiang; Wu, Shu-Nan; Bai, Yu-Guang; Liu, Lei

    2013-04-10

    In this paper, an adaptive law with an integral action is designed and implemented on a DC motor by employing a rotary encoder and tachometer sensors. The stability is proved by using the Lyapunov function. The tracking errors asymptotically converge to zero according to the Barbalat lemma. The tracking performance is specified by a reference model, the convergence rate of Lyapunov function is specified by the matrix Q and the control action and the state weighting are restricted by the matrix Γ. The experimental results demonstrate the effectiveness of the proposed control. The maximum errors of the position and velocity with the integral action are reduced from 0.4 V and 1.5 V to 0.2 V and 0.4 V, respectively. The adaptive control with the integral action gives satisfactory performance, even when it suffers from input disturbance.

  8. Cultural adaptation of preschool PATHS (Promoting Alternative Thinking Strategies) curriculum for Pakistani children.

    PubMed

    Inam, Ayesha; Tariq, Pervaiz N; Zaman, Sahira

    2015-06-01

    Cultural adaptation of evidence-based programmes has gained importance primarily owing to its perceived impact on the established effectiveness of a programme. To date, many researchers have proposed different frameworks for systematic adaptation process. This article presents the cultural adaptation of preschool Promoting Alternative Thinking Strategies (PATHS) curriculum for Pakistani children using the heuristic framework of adaptation (Barrera & Castro, 2006). The study was completed in four steps: information gathering, preliminary adaptation design, preliminary adaptation test and adaptation refinement. Feedbacks on programme content suggested universality of the core programme components. Suggested changes were mostly surface structure: language, presentation of materials, conceptual equivalence of concepts, training needs of implementation staff and frequency of programme delivery. In-depth analysis was done to acquire cultural equivalence. Pilot testing of the outcome measures showed strong internal consistency. The results were further discussed with reference to similar work undertaken in other cultures.

  9. Effects of Self-Statements and Coping Strategies on Adaptational Outcomes of Stress.

    ERIC Educational Resources Information Center

    Uhlemann, Max R.; Plater, Sharon A.

    1989-01-01

    Examined effects of self-statements and coping strategies on adaptational outcomes of stress in female subjects (N=62). Results indicated self-statements did not discriminate significantly between individuals who effectively or ineffectively handled stressful encounters. Only information-seeking coping strategy showed a trend toward a significant…

  10. Acculturation Strategies, Social Support, and Cross-Cultural Adaptation: A Mediation Analysis

    ERIC Educational Resources Information Center

    Ng, Ting Kin; Tsang, Kwok Kuen; Lian, Yi

    2013-01-01

    Previous acculturation research has established the influences of acculturation strategies and social support on cross-cultural adaptation. The present study attempted to elaborate these direct associations by proposing that social support and the use of the integration and marginalization strategies might affect psychological adaptation…

  11. A robust data fusion scheme for integrated navigation systems employing fault detection methodology augmented with fuzzy adaptive filtering

    NASA Astrophysics Data System (ADS)

    Ushaq, Muhammad; Fang, Jiancheng

    2013-10-01

    Integrated navigation systems for various applications, generally employs the centralized Kalman filter (CKF) wherein all measured sensor data are communicated to a single central Kalman filter. The advantage of CKF is that there is a minimal loss of information and high precision under benign conditions. But CKF may suffer computational overloading, and poor fault tolerance. The alternative is the federated Kalman filter (FKF) wherein the local estimates can deliver optimal or suboptimal state estimate as per certain information fusion criterion. FKF has enhanced throughput and multiple level fault detection capability. The Standard CKF or FKF require that the system noise and the measurement noise are zero-mean and Gaussian. Moreover it is assumed that covariance of system and measurement noises remain constant. But if the theoretical and actual statistical features employed in Kalman filter are not compatible, the Kalman filter does not render satisfactory solutions and divergence problems also occur. To resolve such problems, in this paper, an adaptive Kalman filter scheme strengthened with fuzzy inference system (FIS) is employed to adapt the statistical features of contributing sensors, online, in the light of real system dynamics and varying measurement noises. The excessive faults are detected and isolated by employing Chi Square test method. As a case study, the presented scheme has been implemented on Strapdown Inertial Navigation System (SINS) integrated with the Celestial Navigation System (CNS), GPS and Doppler radar using FKF. Collectively the overall system can be termed as SINS/CNS/GPS/Doppler integrated navigation system. The simulation results have validated the effectiveness of the presented scheme with significantly enhanced precision, reliability and fault tolerance. Effectiveness of the scheme has been tested against simulated abnormal errors/noises during different time segments of flight. It is believed that the presented scheme can be

  12. Adaptation strategies to climate change and climate variability: a comparative study between seven contrasting river basins.

    NASA Astrophysics Data System (ADS)

    Droogers, P.

    2003-04-01

    Climate change and climate variability is and will have a tremendous impact on hydrology and consequently on food security and environmental protection. From the four major components in climate change and climate variability studies, projection, mitigation, impact and adaptation, has the latter so far received less attention than the other three. An international collaboration of ten institutions is comparing adaptation strategies between contrasting basins ranging from wet to dry and from poor to rich. Basins included are: Mekong, Walawe (Sri Lanka), Rhine, Sacramento, Syr Darya, Volta, and Zayandeh (Iran). Simulation models at basin and field scale have been set up and possible adaptation strategies are explored by these models. Preliminary results indicate that appropriate adaptation strategies are different between these seven contrasting basins. It is also clear that these adaptation strategies should focus on increased variability rather than on the overall change of the mean. The focus was hereby not only on an increase in variation but especially on the number of successive dry and wet years. Results show that the studies on these adaptation strategies could not be performed only at one scale, but that a combination of field scale as well as basin scale analysis is essential.

  13. Nutritional strategies to modulate the adaptive response to endurance training.

    PubMed

    Hawley, John A

    2013-01-01

    In recent years, advances in molecular biology have allowed scientists to elucidate how endurance exercise training stimulates skeletal muscle remodeling (i.e. promotes mitochondrial biogenesis). A growing field of interest directly arising from our understanding of the molecular bases of training adaptation is how nutrient availability can alter the regulation of many contraction-induced events in muscle in response to endurance exercise. Acutely manipulating substrate availability can exert profound effects on muscle energy stores and patterns of fuel metabolism during exercise, as well as many processes activating gene expression and cell signaling. Accordingly, such interventions when repeated over weeks and months have the potential to modulate numerous adaptive processes in skeletal muscle that ultimately drive the phenotype-specific characteristics observed in highly trained athletes. In this review, the molecular and cellular events that occur in skeletal muscle during and after endurance exercise are discussed and evidence provided to demonstrate that nutrient availability plays an important role in modulating many of the adaptive responses to training. Emphasis is on human studies that have determined the regulatory role of muscle glycogen availability on cell metabolism, endurance training capacity and performance.

  14. [Cold adaptation strategy in insects inhabiting central Yakutia].

    PubMed

    Li, N G; Averenskiĭ, A I

    2007-01-01

    Cold hardiness in 20 insect species living in extremely cold climate of Yakutia has been investigated for the first time. It was shown that the Yakutian insects prefer to use the strategy of freeze tolerance according to which they produce special substances initiating the freezing of hemolymph at high subzero temperatures. The presence of ice-nucleating agents in the haemolymph of insects belonging to the phylogenetic group of Lepidopteran was shown. We postulate that Pieris rapae may shift between the different cold hardiness strategies when they move from moderately cold regions to a more severe environment.

  15. Flexible stocking strategies for adapting to climatic variability

    Technology Transfer Automated Retrieval System (TEKTRAN)

    As a result of precipitation-induced variability on forage production, ranchers have difficulty matching animal demand with forage availability in their operations. Flexible stocking strategies could more effectively use extra forage in highly productive years and limit risk of overgrazing during dr...

  16. MALS: an efficient strategy for multiple site-directed mutagenesis employing a combination of DNA amplification, ligation and suppression PCR

    PubMed Central

    Fushan, Alexey A; Drayna, Dennis T

    2009-01-01

    Background Multiple approaches for the site-directed mutagenesis (SDM) have been developed. However, only several of them are designed for simultaneous introduction of multiple nucleotide alterations, and these are time consuming. In addition, many of the existing multiple SDM methods have technical limitations associated with type and number of mutations that can be introduced, or are technically demanding and require special chemical reagents. Results In this study we developed a quick and efficient strategy for introduction of multiple complex mutations in a target DNA without intermediate subcloning by using a combination of connecting SDM and suppression PCR. The procedure consists of sequential rounds, with each individual round including PCR amplification of target DNA with two non-overlapping pairs of oligonucleotides. The desired mutation is incorporated at the 5' end of one or both internal oligonucleotides. DNA fragments obtained during amplification are mixed and ligated. The resulting DNA mixture is amplified with external oligonucleotides that act as suppression adapters. Suppression PCR limits amplification to DNA molecules representing full length target DNA, while amplification of other types of molecules formed during ligation is suppressed. To create additional mutations, an aliquot of the ligation mixture is then used directly for the next round of mutagenesis employing internal oligonucleotides specific for another region of target DNA. Conclusion A wide variety of complex multiple mutations can be generated in a short period of time. The procedure is rapid, highly efficient and does not require special chemical reagents. Thus, MALS represents a powerful alternative to the existing methods for multiple SDM. PMID:19778447

  17. [Germination strategy and ecological adaptability of Eragrostis pilosa].

    PubMed

    Li, Xuehua; Li, Xiaola; Jiang, Deming; Liu, Zhimin

    2006-04-01

    The study on the germination strategy of Eragrostis pilosa under different storage and environmental conditions showed that freshly collected E. pilosa seeds had a stronger innate dormancy. Chilling and dry storage for 4 months had no obvious effect on releasing from dormancy, while longer time storage could facilitate seed maturation. The seeds could germinate either in light or in darkness, and stronger light was in favor of germination. The optimal temperature for germination was 28 degrees C, while higher or lower temperature could result in the decrease of germination. The germination percentage of seeds under changed temperature (16 to 28 degrees C) was higher than that under constant temperature (28 degrees C), but with no significant difference. The critical amount of rain for seed germination was about 10 mm, and the germination percentage and duration all increased with increasing rainfall. E. pilosa had two germination strategies, i. e., quick germination and dormancy for more than one year. Based on the seed morphological characters and germination strategies, it could be concluded that E. pilosa had a persistent soil seed bank.

  18. Avoided Heat-Related Mortality through Climate Adaptation Strategies in Three US Cities

    PubMed Central

    Stone, Brian; Vargo, Jason; Liu, Peng; Habeeb, Dana; DeLucia, Anthony; Trail, Marcus; Hu, Yongtao; Russell, Armistead

    2014-01-01

    Heat-related mortality in US cities is expected to more than double by the mid-to-late 21st century. Rising heat exposure in cities is projected to result from: 1) climate forcings from changing global atmospheric composition; and 2) local land surface characteristics responsible for the urban heat island effect. The extent to which heat management strategies designed to lessen the urban heat island effect could offset future heat-related mortality remains unexplored in the literature. Using coupled global and regional climate models with a human health effects model, we estimate changes in the number of heat-related deaths in 2050 resulting from modifications to vegetative cover and surface albedo across three climatically and demographically diverse US metropolitan areas: Atlanta, Georgia, Philadelphia, Pennsylvania, and Phoenix, Arizona. Employing separate health impact functions for average warm season and heat wave conditions in 2050, we find combinations of vegetation and albedo enhancement to offset projected increases in heat-related mortality by 40 to 99% across the three metropolitan regions. These results demonstrate the potential for extensive land surface changes in cities to provide adaptive benefits to urban populations at risk for rising heat exposure with climate change. PMID:24964213

  19. Avoided heat-related mortality through climate adaptation strategies in three US cities.

    PubMed

    Stone, Brian; Vargo, Jason; Liu, Peng; Habeeb, Dana; DeLucia, Anthony; Trail, Marcus; Hu, Yongtao; Russell, Armistead

    2014-01-01

    Heat-related mortality in US cities is expected to more than double by the mid-to-late 21st century. Rising heat exposure in cities is projected to result from: 1) climate forcings from changing global atmospheric composition; and 2) local land surface characteristics responsible for the urban heat island effect. The extent to which heat management strategies designed to lessen the urban heat island effect could offset future heat-related mortality remains unexplored in the literature. Using coupled global and regional climate models with a human health effects model, we estimate changes in the number of heat-related deaths in 2050 resulting from modifications to vegetative cover and surface albedo across three climatically and demographically diverse US metropolitan areas: Atlanta, Georgia, Philadelphia, Pennsylvania, and Phoenix, Arizona. Employing separate health impact functions for average warm season and heat wave conditions in 2050, we find combinations of vegetation and albedo enhancement to offset projected increases in heat-related mortality by 40 to 99% across the three metropolitan regions. These results demonstrate the potential for extensive land surface changes in cities to provide adaptive benefits to urban populations at risk for rising heat exposure with climate change.

  20. Using a social justice and health framework to assess European climate change adaptation strategies.

    PubMed

    Boeckmann, Melanie; Zeeb, Hajo

    2014-11-28

    Climate change puts pressure on existing health vulnerabilities through higher frequency of extreme weather events, changes in disease vector distribution or exacerbated air pollution. Climate change adaptation policies may hold potential to reduce societal inequities. We assessed the role of public health and social justice in European climate change adaptation using a three-fold approach: a document analysis, a critical discourse analysis of a subgroup of strategies, and a ranking of strategies against our social justice framework. The ranking approach favored planning that includes various adaptation types, social issues and infrastructure changes. Themes on values identified in the five subgroup documents showed that risks are perceived as contradictory, technology is viewed as savior, responsibilities need to be negotiated, and social justice is advocated by only a few countries. Of 21 strategy documents assessed overall, those from Austria, England and Sweden received the highest scores in the ranking. Our qualitative assessment showed that in European adaptation planning, progress could still be made through community involvement into adaptation decisions, consistent consideration of social and demographic determinants, and a stronger link between infrastructural adaptation and the health sector. Overall, a social justice framework can serve as an evaluation guideline for adaptation policy documents.

  1. Using a Social Justice and Health Framework to Assess European Climate Change Adaptation Strategies

    PubMed Central

    Boeckmann, Melanie; Zeeb, Hajo

    2014-01-01

    Climate change puts pressure on existing health vulnerabilities through higher frequency of extreme weather events, changes in disease vector distribution or exacerbated air pollution. Climate change adaptation policies may hold potential to reduce societal inequities. We assessed the role of public health and social justice in European climate change adaptation using a three-fold approach: a document analysis, a critical discourse analysis of a subgroup of strategies, and a ranking of strategies against our social justice framework. The ranking approach favored planning that includes various adaptation types, social issues and infrastructure changes. Themes on values identified in the five subgroup documents showed that risks are perceived as contradictory, technology is viewed as savior, responsibilities need to be negotiated, and social justice is advocated by only a few countries. Of 21 strategy documents assessed overall, those from Austria, England and Sweden received the highest scores in the ranking. Our qualitative assessment showed that in European adaptation planning, progress could still be made through community involvement into adaptation decisions, consistent consideration of social and demographic determinants, and a stronger link between infrastructural adaptation and the health sector. Overall, a social justice framework can serve as an evaluation guideline for adaptation policy documents. PMID:25464133

  2. Compensating Losses in Bridge Employment? Examining Relations between Compensation Strategies, Health Problems, and Intention to Remain at Work

    ERIC Educational Resources Information Center

    Muller, Andreas; De Lange, Annet; Weigl, Matthias; Oxfart, Caroline; Van der Heijden, Beatrice

    2013-01-01

    In order to better understand the precursors of bridge employment, this study aimed to investigate whether individual action strategies in terms of selection, optimization, and compensation (SOC; Baltes & Baltes, 1990) are able to buffer the well-known negative impact of poor health on the intention to remain in the workforce. 784 employees (60-85…

  3. Effects of Employing the Text, SRA Decoding Strategies on the Word Recognition for a High School Student with Learning Disabilities

    ERIC Educational Resources Information Center

    Lykken, Alyson; Wakeman, Julie; Neyman, Jennifer; McLaughlin, T. F.; Zumwalt, Kim

    2014-01-01

    An objective of this study was to evaluate the effects of employing the SRA Decoding Strategies text on word recognition for a ninth grade male with a learning disability. The student was enrolled in a high school special education resource room in a large urban school district in the Pacific North west in a direct instruction reading resource…

  4. Adaptive learning in complex reproducing kernel Hilbert spaces employing Wirtinger's subgradients.

    PubMed

    Bouboulis, Pantelis; Slavakis, Konstantinos; Theodoridis, Sergios

    2012-03-01

    This paper presents a wide framework for non-linear online supervised learning tasks in the context of complex valued signal processing. The (complex) input data are mapped into a complex reproducing kernel Hilbert space (RKHS), where the learning phase is taking place. Both pure complex kernels and real kernels (via the complexification trick) can be employed. Moreover, any convex, continuous and not necessarily differentiable function can be used to measure the loss between the output of the specific system and the desired response. The only requirement is the subgradient of the adopted loss function to be available in an analytic form. In order to derive analytically the subgradients, the principles of the (recently developed) Wirtinger's calculus in complex RKHS are exploited. Furthermore, both linear and widely linear (in RKHS) estimation filters are considered. To cope with the problem of increasing memory requirements, which is present in almost all online schemes in RKHS, the sparsification scheme, based on projection onto closed balls, has been adopted. We demonstrate the effectiveness of the proposed framework in a non-linear channel identification task, a non-linear channel equalization problem and a quadrature phase shift keying equalization scheme, using both circular and non circular synthetic signal sources.

  5. Urban plant physiology: adaptation-mitigation strategies under permanent stress.

    PubMed

    Calfapietra, Carlo; Peñuelas, Josep; Niinemets, Ülo

    2015-02-01

    Urban environments that are stressful for plant function and growth will become increasingly widespread in future. In this opinion article, we define the concept of 'urban plant physiology', which focuses on plant responses and long term adaptations to urban conditions and on the capacity of urban vegetation to mitigate environmental hazards in urbanized settings such as air and soil pollution. Use of appropriate control treatments would allow for studies in urban environments to be comparable to expensive manipulative experiments. In this opinion article, we propose to couple two approaches, based either on environmental gradients or manipulated gradients, to develop the concept of urban plant physiology for assessing how single or multiple environmental factors affect the key environmental services provided by urban forests.

  6. Suppressing traffic-driven epidemic spreading by adaptive routing strategy

    NASA Astrophysics Data System (ADS)

    Yang, Han-Xin; Wang, Zhen

    2016-12-01

    Despite extensive work on the interplay between traffic dynamics and epidemic spreading, the control of epidemic spreading by routing strategies has not received adequate attention. In this paper, we study the impact of efficient routing protocol on epidemic spreading. In the case of infinite node-delivery capacity, where the traffic is free of congestion, we find that that there exists optimal values of routing parameter, leading to the maximal epidemic threshold. This means that epidemic spreading can be effectively controlled by fine tuning the routing scheme. Moreover, we find that an increase in the average network connectivity and the emergence of traffic congestion can suppress the epidemic outbreak.

  7. A Structure-Adaptive Hybrid RBF-BP Classifier with an Optimized Learning Strategy.

    PubMed

    Wen, Hui; Xie, Weixin; Pei, Jihong

    2016-01-01

    This paper presents a structure-adaptive hybrid RBF-BP (SAHRBF-BP) classifier with an optimized learning strategy. SAHRBF-BP is composed of a structure-adaptive RBF network and a BP network of cascade, where the number of RBF hidden nodes is adjusted adaptively according to the distribution of sample space, the adaptive RBF network is used for nonlinear kernel mapping and the BP network is used for nonlinear classification. The optimized learning strategy is as follows: firstly, a potential function is introduced into training sample space to adaptively determine the number of initial RBF hidden nodes and node parameters, and a form of heterogeneous samples repulsive force is designed to further optimize each generated RBF hidden node parameters, the optimized structure-adaptive RBF network is used for adaptively nonlinear mapping the sample space; then, according to the number of adaptively generated RBF hidden nodes, the number of subsequent BP input nodes can be determined, and the overall SAHRBF-BP classifier is built up; finally, different training sample sets are used to train the BP network parameters in SAHRBF-BP. Compared with other algorithms applied to different data sets, experiments show the superiority of SAHRBF-BP. Especially on most low dimensional and large number of data sets, the classification performance of SAHRBF-BP outperforms other training SLFNs algorithms.

  8. A Structure-Adaptive Hybrid RBF-BP Classifier with an Optimized Learning Strategy

    PubMed Central

    Wen, Hui; Xie, Weixin; Pei, Jihong

    2016-01-01

    This paper presents a structure-adaptive hybrid RBF-BP (SAHRBF-BP) classifier with an optimized learning strategy. SAHRBF-BP is composed of a structure-adaptive RBF network and a BP network of cascade, where the number of RBF hidden nodes is adjusted adaptively according to the distribution of sample space, the adaptive RBF network is used for nonlinear kernel mapping and the BP network is used for nonlinear classification. The optimized learning strategy is as follows: firstly, a potential function is introduced into training sample space to adaptively determine the number of initial RBF hidden nodes and node parameters, and a form of heterogeneous samples repulsive force is designed to further optimize each generated RBF hidden node parameters, the optimized structure-adaptive RBF network is used for adaptively nonlinear mapping the sample space; then, according to the number of adaptively generated RBF hidden nodes, the number of subsequent BP input nodes can be determined, and the overall SAHRBF-BP classifier is built up; finally, different training sample sets are used to train the BP network parameters in SAHRBF-BP. Compared with other algorithms applied to different data sets, experiments show the superiority of SAHRBF-BP. Especially on most low dimensional and large number of data sets, the classification performance of SAHRBF-BP outperforms other training SLFNs algorithms. PMID:27792737

  9. Domain adaptation problems: a DASVM classification technique and a circular validation strategy.

    PubMed

    Bruzzone, Lorenzo; Marconcini, Mattia

    2010-05-01

    This paper addresses pattern classification in the framework of domain adaptation by considering methods that solve problems in which training data are assumed to be available only for a source domain different (even if related) from the target domain of (unlabeled) test data. Two main novel contributions are proposed: 1) a domain adaptation support vector machine (DASVM) technique which extends the formulation of support vector machines (SVMs) to the domain adaptation framework and 2) a circular indirect accuracy assessment strategy for validating the learning of domain adaptation classifiers when no true labels for the target--domain instances are available. Experimental results, obtained on a series of two-dimensional toy problems and on two real data sets related to brain computer interface and remote sensing applications, confirmed the effectiveness and the reliability of both the DASVM technique and the proposed circular validation strategy.

  10. Numerous strategies but limited implementation guidance in US local adaptation plans

    NASA Astrophysics Data System (ADS)

    Woodruff, Sierra C.; Stults, Missy

    2016-08-01

    Adaptation planning offers a promising approach for identifying and devising solutions to address local climate change impacts. Yet there is little empirical understanding of the content and quality of these plans. We use content analysis to evaluate 44 local adaptation plans in the United States and multivariate regression to examine how plan quality varies across communities. We find that plans draw on multiple data sources to analyse future climate impacts and include a breadth of strategies. Most plans, however, fail to prioritize impacts and strategies or provide detailed implementation processes, raising concerns about whether adaptation plans will translate into on-the-ground reductions in vulnerability. Our analysis also finds that plans authored by the planning department and those that engaged elected officials in the planning process were of higher quality. The results provide important insights for practitioners, policymakers and scientists wanting to improve local climate adaptation planning and action.

  11. Engaging Communities in Identifying Local Strategies for Expanding Integrated Employment during and after High School

    ERIC Educational Resources Information Center

    Carter, Erik W.; Blustein, Carly L.; Bumble, Jennifer L.; Harvey, Sarah; Henderson, Lynnette M.; McMillan, Elise D.

    2016-01-01

    Amidst decades of attention directed toward improving employment outcomes for people with intellectual and developmental disabilities (IDD), few efforts have been made to engage communities in identifying local solutions for expanding integrated employment opportunities. We examined the implementation and outcomes of "community…

  12. Strategies and Procedures Used in Developing Goals for an Equal Employment Opportunity Affirmative Action Program

    ERIC Educational Resources Information Center

    Belanger, Charles H.; Coleman, Daniel R.

    1975-01-01

    Basic issues involved in planning and implementation of a equal employment opportunity plan are outlined: leadership, constraints, data requirements, administrative responsibilities, policies and procedures (recruitment, selection, employment, promotion-termination, remuneration, assignment, grievance, subcontractor-supplier, leave, and benefits),…

  13. Collaboration between Supported Employment and Human Resource Services: Strategies for Success

    ERIC Educational Resources Information Center

    Post, Michal; Campbell, Camille; Heinz, Tom; Kotsonas, Lori; Montgomery, Joyce; Storey, Keith

    2010-01-01

    The article presents the benefits of successful collaboration between supported employment agencies and human resource managers when working together to secure employment for individuals with disabilities. Two case studies are presented: one involving a successful collaboration with county human resource managers in negotiating a change in the…

  14. Chinese International Students' Perspective and Strategies in Preparing for Their Future Employability

    ERIC Educational Resources Information Center

    Huang, Rong; Turner, Rebecca; Chen, Qian

    2014-01-01

    Graduate employability and the contribution graduates make to the UK economy have been widely debated by policy-makers; however, little attention has been paid to the employability of international students. Given the growing significance of international students to the UK economy this is an interesting oversight; this article addresses this…

  15. Machining Strategy to Adapt Cutting Conditions under Digital Copy Milling Concept

    NASA Astrophysics Data System (ADS)

    Shimada, Takashi; Nakamoto, Keiichi; Shirase, Keiichi

    Most machining tools are controlled by numerical control (NC) programs in order to achieve unmanned machining operations with high precision and improved productivity. However, all the movements of the machining tool are predetermined, and all instructions coded in the NC program are performed sequentially. Therefore, since the cutting process is not adaptable during unmanned machining, the cutting conditions should be set conservatively to avoid cutting difficulties. In this study, machining strategies for adapting the cutting process during a milling operation to avoid tool breakage and to stabilize cutting load have been integrated into an autonomous NC machining tool developed under the Digital Copy Milling (DCM) concept for generating a tool path in real time. In machining strategies, feed speed, radial and axial depths of cut are adapted according to cutting load detected from load cells in the machining table. Successful endmilling experiments verified the effectiveness of the developed machining strategy.

  16. Leaf Area Adjustment As an Optimal Drought-Adaptation Strategy

    NASA Astrophysics Data System (ADS)

    Manzoni, S.; Beyer, F.; Thompson, S. E.; Vico, G.; Weih, M.

    2014-12-01

    Leaf phenology plays a major role in land-atmosphere mass and energy exchanges. Much work has focused on phenological responses to light and temperature, but less to leaf area changes during dry periods. Because the duration of droughts is expected to increase under future climates in seasonally-dry as well as mesic environments, it is crucial to (i) predict drought-related phenological changes and (ii) to develop physiologically-sound models of leaf area dynamics during dry periods. Several optimization criteria have been proposed to model leaf area adjustment as soil moisture decreases. Some theories are based on the plant carbon (C) balance, hypothesizing that leaf area will decline when instantaneous net photosynthetic rates become negative (equivalent to maximization of cumulative C gain). Other theories draw on hydraulic principles, suggesting that leaf area should adjust to either maintain a constant leaf water potential (isohydric behavior) or to avoid leaf water potentials with negative impacts on photosynthesis (i.e., minimization of water stress). Evergreen leaf phenology is considered as a control case. Merging these theories into a unified framework, we quantify the effect of phenological strategy and climate forcing on the net C gain over the entire growing season. By accounting for the C costs of leaf flushing and the gains stemming from leaf photosynthesis, this metric assesses the effectiveness of different phenological strategies, under different climatic scenarios. Evergreen species are favored only when the dry period is relatively short, as they can exploit most of the growing season, and only incur leaf maintenance costs during the short dry period. In contrast, deciduous species that lower maintenance costs by losing leaves are advantaged under drier climates. Moreover, among drought-deciduous species, isohydric behavior leads to lowest C gains. Losing leaves gradually so as to maintain a net C uptake equal to zero during the driest period in

  17. Water adaptation strategy in anuran amphibians: molecular diversity of aquaporin.

    PubMed

    Ogushi, Yuji; Akabane, Gen; Hasegawa, Takahiro; Mochida, Hiroshi; Matsuda, Manabu; Suzuki, Masakazu; Tanaka, Shigeyasu

    2010-01-01

    Most adult anuran amphibians except for the aquatic species absorb water across the ventral pelvic skin and reabsorb it from urine in the urinary bladder. Many terrestrial and arboreal species use a region in the posterior or pelvic region of the ventral skin that is specialized for rapid rehydration from shallow water sources or moist substrates. Periods of terrestrial activity can be prolonged by reabsorption of dilute urine from the urinary bladder. Aquaporin (AQP), a water channel protein, plays a fundamental role in these water absorption/reabsorption processes, which are regulated by antidiuretic hormone. Characterization of AQPs from various anurans revealed that the unique water homeostasis is basically mediated by two types of anuran-specific AQPs, i.e. ventral pelvic skin and urinary bladder type, respectively. The bladder-type AQP is further expressed in the pelvic skin of terrestrial and arboreal species, together with the pelvic skin-type AQP. In contrast, the pelvic skin-type AQP (AQP-x3) of the aquatic Xenopus has lost the ability of efficient protein production. The extra C-terminal tail in AQP-x3 consisting of 33 nucleotides within the coding region appears to participate in the posttranscriptional regulation of AQP-x3 gene expression by attenuating protein expression. The positive transcriptional regulation of bladder-type AQP in the pelvic skin and negative posttranscriptional regulation of pelvic skin-type AQP provide flexibility in the water regulation mechanisms, which might have contributed to the evolutionary adaptation of anurans to a wide variety of water environments.

  18. Paradoxical cardiovascular effects of implementing adaptive emotion regulation strategies in generalized anxiety disorder.

    PubMed

    Aldao, Amelia; Mennin, Douglas S

    2012-02-01

    Recent models of generalized anxiety disorder (GAD) have expanded on Borkovec's avoidance theory by delineating emotion regulation deficits associated with the excessive worry characteristic of this disorder (see Behar, DiMarco, Hekler, Mohlman, & Staples, 2009). However, it has been difficult to determine whether emotion regulation is simply a useful heuristic for the avoidant properties of worry or an important extension to conceptualizations of GAD. Some of this difficulty may arise from a focus on purported maladaptive regulation strategies, which may be confounded with symptomatic distress components of the disorder (such as worry). We examined the implementation of adaptive regulation strategies by participants with and without a diagnosis of GAD while watching emotion-eliciting film clips. In a between-subjects design, participants were randomly assigned to accept, reappraise, or were not given specific regulation instructions. Implementation of adaptive regulation strategies produced differential effects in the physiological (but not subjective) domain across diagnostic groups. Whereas participants with GAD demonstrated lower cardiac flexibility when implementing adaptive regulation strategies than when not given specific instructions on how to regulate, healthy controls showed the opposite pattern, suggesting they benefited from the use of adaptive regulation strategies. We discuss the implications of these findings for the delineation of emotion regulation deficits in psychopathology.

  19. Development of adaptation strategies of marshland water management to regional climate change

    NASA Astrophysics Data System (ADS)

    Bormann, Helge; Frank, Ahlhorn; Luise, Giani; Kirsten, Klaassen; Thomas, Klenke

    2010-05-01

    , alternative strategies for a future water management were developed. They are based on the stakeholder's picture of their future landscape, describing how the region should look like in year 2050, considering the landscape in general as well as socioeconomic aspects such as land use, employment market and tourism. And they are also based on guiding principles of future water management on which all stakeholders agreed. In comparison with the list of potential measures suggested by regional stakeholders, a concept is presented which was developed by a group of international water management experts from Netherlands, UK, Sweden and Belgium in the framework of a project workshop of the EU-Interreg IVb ‘Climate Proof Areas' project. This comparison highlights the impact of setting certain boundary conditions of a future development, i.e. the sustainable development of the future landscape versus keeping the landscape and its cultural heritage as it is now, for example by maintaining the traditional farming system as fundamental precondition for the climate adaptation process. Setting these priorities governs the decision making process and decides whether the focus is set on technical adaptation measures in contrast to alternative land use concepts for a region.

  20. [Adaptation strategies of halophilic microorganisms and Debaryomyces hansenii (halophilic yeast)].

    PubMed

    González-Hernández, Juan Carlos; Peña, Antonio

    2002-01-01

    The term halophile is used for all those organisms belonging to hypersaline habitats; they constitute an interesting class of organisms able to compete successfully in salt water and to resist its denaturing effects. A wide diversity of microorganisms, prokaryotic and eukaryotic belong to this category. Halophile organisms have strategies allowing them not only to withstand osmotic stress, but also to function better in the presence of salt, in spite of maintaining high intracellular concentrations of salt, partly due to the synthesis of compatible solutes that allow them to balance their osmotic pressure. We describe the characteristics of some halophile organisms and D. hansenii (halophile yeast), that allow them to resist high concentrations of salt. The interest to know the great diversity microorganisms living in hypersaline habitats is growing, and has begun to be the center of recent investigations, since halophile organisms produce an wide variety of biomolecules that can be used for different applications. In this review we describe some mechanisms with which some halophile organisms count to resist the high concentration of salts, mainly NaCl.

  1. Fuel consumptions and exhaust emissions induced by cooperative adaptive cruise control strategies

    NASA Astrophysics Data System (ADS)

    Yu, Shaowei; Shi, Zhongke

    2015-04-01

    Many cooperative adaptive cruise control strategies have been presented to improve traffic efficiency as well as road traffic safety, but scholars have rarely explored the impacts of these strategies on cars' fuel consumptions and exhaust emissions. In this paper, we respectively select two-velocity difference model, multiple velocity difference model and the car-following model considering multiple preceding cars' accelerations to investigate each car's fuel consumptions, carbon monoxide (CO), hydrocarbons (HC) and nitrogen oxides (NOX) emissions and carry out comparative analysis. The comparisons of fuel consumptions and exhaust emissions in three different cruise control strategies show that cooperative cars simulated by the car-following model considering multiple preceding cars' accelerations can run with the minimal fuel consumptions, CO, HC and NOX emissions, thus, taking the car-following model considering multiple preceding cars' accelerations as the cooperative adaptive cruise control strategy can significantly improve cars' fuel efficiency and exhaust emissions.

  2. Relationship between University Level and Employment of Language-Learning Strategies: A Study of EAP Learners

    ERIC Educational Resources Information Center

    Ghafournia, Narjes

    2014-01-01

    This study scrutinized the relationship between utilizing language-learning strategies and university levels in reading-comprehension process of language learners in Iran. The participants comprised 406 EAP students at three university levels. The findings reflected significant differences among the students in implementing learning strategies.…

  3. Reading Strategies Employed by University Business English Majors with Different Levels of Reading Proficiency

    ERIC Educational Resources Information Center

    Chen, Jun; Intaraprasert, Channarong

    2014-01-01

    The purpose of this study was to investigate the use of reading strategies by the university Business English majors in relation to their levels of reading proficiency. The participants were 926 university Business English majors from 6 universities in southwest China. The Strategy Questionnaire for Business English Reading (SQBER) and the…

  4. Strategies of Mesenchymal Invasion of Patient-derived Brain Tumors: Microenvironmental Adaptation

    PubMed Central

    Cha, Junghwa; Kang, Seok-Gu; Kim, Pilnam

    2016-01-01

    The high mortality in glioblastoma multiforme (GBM) patients is primarily caused by extensive infiltration into adjacent tissue and subsequent rapid recurrence. There are no clear therapeutic strategies that target the infiltrative subpopulation of GBM mass. Using mesenchymal mode of invasion, the GBM is known to widely infiltrate by interacting with various unique components within brain microenvironment such as hyaluronic acid (HA)-rich matrix and white matter tracts. However, it is unclear how these GBM microenvironments influence the strategies of mesenchymal invasion. We hypothesize that GBM has different strategies to facilitate such invasion through adaptation to their local microenvironment. Using our in vitro biomimetic microenvironment platform for three-dimensional GBM tumorspheres (TSs), we found that the strategies of GBM invasion were predominantly regulated by the HA-rich ECM microenvironment, showing marked phenotypic changes in the presence of HA, which were mainly mediated by HA synthase (HAS). Interestingly, after inhibition of the HAS gene, GBM switched their invasion strategies to a focal adhesion (FA)-mediated invasion. These results demonstrate that the microenvironmental adaptation allowed a flexible invasion strategy for GBM. Using our model, we suggest a new inhibitory pathway for targeting infiltrative GBM and propose an importance of multi-target therapy for GBM, which underwent microenvironmental adaptation. PMID:27108713

  5. Climate Variability: Adaptation Strategies for Colorado River Management

    NASA Astrophysics Data System (ADS)

    Fulp, T. J.; Prairie, J. R.

    2008-12-01

    impossible to precisely predict future inflows, a range of possible inflows were analyzed and used to quantify the uncertainty with respect to inflows, which by far dominates the overall uncertainty. Although Reclamation had typically used a technique that resamples the historical record to generate future hydrologic inflow scenarios, new techniques were used in this EIS in order to better quantify the uncertainties. These techniques were the outcome of a multi-faceted research and development program begun in 2004 to enable the use of other methods for projecting possible future inflow sequences for Colorado River planning studies. The techniques employed in this EIS included resampling from a new paleo-reconstruction of Colorado River flows dating back to 762 A.D. and a hybrid technique that couples the state information derived from the paleo-record (i.e., wet, dry) with the historical record to generate future sequences that have not been seen in the past. Additional research is both needed and warranted to better quantify the uncertainties and the risks of current and future water resource management decisions and Reclamation is continuing its research effort, working with other governmental agencies and universities, to further its ability to use climate information in its decision-making.

  6. Experimental Investigation of Human Adaptation to Change in Agent's Strategy through a Competitive Two-Player Game

    NASA Astrophysics Data System (ADS)

    Terada, Kazunori; Yamada, Seiji; Ito, Akira

    We conducted an experimental investigation on human adaptation to change in an agent's strategy through a competitive two-player game. Modeling the process of human adaptation to agents is important for designing intelligent interface agents and adaptive user interfaces that learn a user's preferences and behavior strategy. However, few studies on human adaptation to such an agent have been done. We propose a human adaptation model for a two-player game. We prepared an on-line experimental system in which a participant and an agent play a repeated penny-matching game with a bonus round. We then conducted experiments in which different opponent agents (human or robot) change their strategy during the game. The experimental results indicated that, as expected, there is an adaptation phase when a human is confronted with a change in the opponent agent's strategy, and adaptation is faster when a human is competing with robot than with another human.

  7. The importance of training strategy adaptation: a learner-oriented approach for improving older adults' memory and transfer.

    PubMed

    Bottiroli, Sara; Cavallini, Elena; Dunlosky, John; Vecchi, Tomaso; Hertzog, Christopher

    2013-09-01

    We investigated the benefits of strategy-adaptation training for promoting transfer effects. This learner-oriented approach--which directly encourages the learner to generalize strategic behavior to new tasks--helps older adults appraise new tasks and adapt trained strategies to them. In Experiment 1, older adults in a strategy-adaptation training group used 2 strategies (imagery and sentence generation) while practicing 2 tasks (list and associative learning); they were then instructed on how to do a simple task analysis to help them adapt the trained strategies for 2 different unpracticed tasks (place learning and text learning) that were discussed during training. Two additional criterion tasks (name-face associative learning and grocery-list learning) were never mentioned during training. Two other groups were included: A strategy training group (who received strategy training and transfer instructions but not strategy-adaptation training) and a waiting-list control group. Both training procedures enhanced older adults' performance on the trained tasks and those tasks that were discussed during training, but transfer was greatest after strategy-adaptation training. Experiment 2 found that strategy-adaptation training conducted via a manual that older adults used at home also promoted transfer. These findings demonstrate the importance of adopting a learner-oriented approach to promote transfer of strategy training.

  8. Evolution of the fruit endocarp: molecular mechanisms underlying adaptations in seed protection and dispersal strategies

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Plant evolution is largely driven by adaptations in seed protection and dispersal strategies that allow diversification into new niches. This is evident by the tremendous variation in flowering and fruiting structures present both across and within different plant lineages. Within a single plant f...

  9. Identity Formation as a Contemporary Adaptation Strategy: Chinese Immigrants in Italy

    ERIC Educational Resources Information Center

    Mleczko, Agata

    2011-01-01

    This article uses the theory of bright vs. blurred boundaries of Alba (2005) and the adaptation strategies of Berry (2005) to explore the national context of the process of identity formation. Issues of citizenship, language, religion, and race are discussed within the national context of Italy. The study is based on field research among the…

  10. Immune evasion by cytomegalovirus--survival strategies of a highly adapted opportunist.

    PubMed

    Hengel, H; Brune, W; Koszinowski, U H

    1998-05-01

    Slowly replicating, species-specific and complex DNA viruses, such as cytomegaloviruses (CMVs), which code for > 200 antigenic proteins, should be easy prey to the host's immune system. Yet, CMVs are amazingly adapted opportunists that cope with multiple immune responses. Frequently, CMVs exploit immune mechanisms generated by the host. These strategies secure the persistence of CMVs and provide opportunities to spread to naive individuals.

  11. Rangeland management strategies for adapting to climatic variability: Enhancing the positive and mitigating the negative effects

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Rangeland management strategies for adapting to climatic variability are needed to reduce enterprise risk, increase resilience of rangeland/grassland ecosystems and deliver sustainable provision of ecosystem goods (e.g., livestock production) and services (e.g., wildlife habitat) from western North ...

  12. The Effect of Adaptive Confidence Strategies in Computer-Assisted Instruction on Learning and Learner Confidence

    ERIC Educational Resources Information Center

    Warren, Richard Daniel

    2012-01-01

    The purpose of this research was to investigate the effects of including adaptive confidence strategies in instructionally sound computer-assisted instruction (CAI) on learning and learner confidence. Seventy-one general educational development (GED) learners recruited from various GED learning centers at community colleges in the southeast United…

  13. Behavioral Contexts, Food-Choice Coping Strategies, and Dietary Quality of a Multiethnic Sample of Employed Parents

    PubMed Central

    Blake, Christine E.; Wethington, Elaine; Farrell, Tracy J.; Bisogni, Carole A.; Devine, Carol M.

    2012-01-01

    Employed parents’ work and family conditions provide behavioral contexts for their food choices. Relationships between employed parents’ food-choice coping strategies, behavioral contexts, and dietary quality were evaluated. Data on work and family conditions, sociodemographic characteristics, eating behavior, and dietary intake from two 24-hour dietary recalls were collected in a random sample cross-sectional pilot telephone survey in the fall of 2006. Black, white, and Latino employed mothers (n=25) and fathers (n=25) were recruited from a low/moderate income urban area in upstate New York. Hierarchical cluster analysis (Ward’s method) identified three clusters of parents differing in use of food-choice coping strategies (ie, Individualized Eating, Missing Meals, and Home Cooking). Cluster sociodemographic, work, and family characteristics were compared using χ2 and Fisher’s exact tests. Cluster differences in dietary quality (Healthy Eating Index 2005) were analyzed using analysis of variance. Clusters differed significantly (P≤0.05) on food-choice coping strategies, dietary quality, and behavioral contexts (ie, work schedule, marital status, partner’s employment, and number of children). Individualized Eating and Missing Meals clusters were characterized by nonstandard work hours, having a working partner, single parenthood and with family meals away from home, grabbing quick food instead of a meal, using convenience entrées at home, and missing meals or individualized eating. The Home Cooking cluster included considerably more married fathers with nonemployed spouses and more home-cooked family meals. Food-choice coping strategies affecting dietary quality reflect parents’ work and family conditions. Nutritional guidance and family policy needs to consider these important behavioral contexts for family nutrition and health. PMID:21338739

  14. Adaptive pinning control: A review of the fully decentralized strategy and its extensions

    NASA Astrophysics Data System (ADS)

    Turci, L. F. R.; De Lellis, P.; Macau, E. E. N.; Di Bernardo, M.; Simões, M. M. R.

    2014-12-01

    In this work, we review recent developments related to the problem of guiding a complex network of agents toward a synchronized state. Specifically, we focus on adaptive pinning control strategies, expounding those developed by the authors in the context of the existing literature, in which only a small fraction of the network nodes is directly controlled. The methodologies described herein are adaptive in the sense that the control and coupling gains are updated on the basis of the local mismatch with the desired trajectory and between coupled nodes, respectively. A selection of adaptive strategies recently proposed in the literature is reviewed, and the main stability results are expounded. As a numerical validation, the selected approaches are applied to control an ensemble of coupled mobile agents moving in a formation.

  15. Dosimetric evaluation of three adaptive strategies for prostate cancer treatment including pelvic lymph nodes irradiation

    SciTech Connect

    Cantin, Audrey; Gingras, Luc; Archambault, Louis; Lachance, Bernard; Foster, William; Goudreault, Julie

    2015-12-15

    Purpose: The movements of the prostate relative to the pelvic lymph nodes during intensity-modulated radiation therapy treatment can limit margin reduction and affect the protection of the organs at risk (OAR). In this study, the authors performed an analysis of three adaptive treatment strategies that combine information from both bony and gold marker registrations. The robustness of those treatments against the interfraction prostate movements was evaluated. Methods: A retrospective study was conducted on five prostate cancer patients with 7–13 daily cone-beam CTs (CBCTs). The clinical target volumes (CTVs) consisting of pelvic lymph nodes, prostate, and seminal vesicles as well as the OARs were delineated on each CBCT and the initial CT. Three adaptive strategies were analyzed. Two of these methods relied on a two-step patient positioning at each fraction. First step: a bony registration was used to deliver the nodal CTV prescription. Second step: a gold marker registration was then used either to (1) complete the dose delivered to the prostate (complement); (2) or give almost the entire prescription to the prostate with a weak dose gradient between the targets to compensate for possible motions (gradient). The third method (COR) used a pool of precalculated plans based on images acquired at previous treatment fractions. At each new fraction, a plan is selected from that pool based on the daily position of prostate center-of-mass. The dosimetric comparison was conducted and results are presented with and without the systematic shift in the prostate position on the CT planning. The adaptive strategies were compared to the current clinical standard where all fractions are treated with the initial nonadaptive plan. Results: The minimum daily prostate D{sub 95%} is improved by 2%, 9%, and 6% for the complement, the gradient, and the COR approaches, respectively, compared to the nonadaptive method. The average nodal CTV D{sub 95%} remains constant across the

  16. Increasing the Value of Age: Guidance in Employers' Age Management Strategies. Research Paper No 44

    ERIC Educational Resources Information Center

    Cedefop - European Centre for the Development of Vocational Training, 2015

    2015-01-01

    The European active population is ageing. In the face of growing skills shortages, both national States and employers need to prolong the working lives of their most experienced workers. While enterprises strive to respond to this challenge, most still have not fully explored the potential of guidance activities in addressing age-related issues in…

  17. Classifying University Employability Strategies: Three Case Studies and Implications for Practice and Research

    ERIC Educational Resources Information Center

    Farenga, Stéphane A.; Quinlan, Kathleen M.

    2016-01-01

    This qualitative study documents three main strategic models used by Russell Group Careers Services to support students' preparation for graduate careers. It is framed against the backdrop of a challenging graduate labour market, discussions of employability in the literature and the policy assumption that universities are responsible for…

  18. Divergent Adaptive Strategies by Two Co-occurring Epiphytic Orchids to Water Stress: Escape or Avoidance?

    PubMed

    Zhang, Wei; Hu, Hong; Zhang, Shi-Bao

    2016-01-01

    uptake and storage, and by reducing water losses while P. albiflora employs a drought escape strategy by fixing more carbon during growing season and shedding leaves and roots at dry season, leaving a dormant pseudobulb to minimize transpiration. These findings may improve our understanding of the potential effects that climate change can have on the population dynamics of different epiphytic taxa.

  19. Divergent Adaptive Strategies by Two Co-occurring Epiphytic Orchids to Water Stress: Escape or Avoidance?

    PubMed Central

    Zhang, Wei; Hu, Hong; Zhang, Shi-Bao

    2016-01-01

    uptake and storage, and by reducing water losses while P. albiflora employs a drought escape strategy by fixing more carbon during growing season and shedding leaves and roots at dry season, leaving a dormant pseudobulb to minimize transpiration. These findings may improve our understanding of the potential effects that climate change can have on the population dynamics of different epiphytic taxa. PMID:27200059

  20. Adapting to Adaptations: Behavioural Strategies that are Robust to Mutations and Other Organisational-Transformations.

    PubMed

    Egbert, Matthew D; Pérez-Mercader, Juan

    2016-01-08

    Genetic mutations, infection by parasites or symbionts, and other events can transform the way that an organism's internal state changes in response to a given environment. We use a minimalistic computational model to support an argument that by behaving "interoceptively," i.e. responding to internal state rather than to the environment, organisms can be robust to these organisational-transformations. We suggest that the robustness of interoceptive behaviour is due, in part, to the asymmetrical relationship between an organism and its environment, where the latter more substantially influences the former than vice versa. This relationship means that interoceptive behaviour can respond to the environment, the internal state and the interaction between the two, while exteroceptive behaviour can only respond to the environment. We discuss the possibilities that (i) interoceptive behaviour may play an important role of facilitating adaptive evolution (especially in the early evolution of primitive life) and (ii) interoceptive mechanisms could prove useful in efforts to create more robust synthetic life-forms.

  1. Adapting to Adaptations: Behavioural Strategies that are Robust to Mutations and Other Organisational-Transformations

    PubMed Central

    Egbert, Matthew D.; Pérez-Mercader, Juan

    2016-01-01

    Genetic mutations, infection by parasites or symbionts, and other events can transform the way that an organism’s internal state changes in response to a given environment. We use a minimalistic computational model to support an argument that by behaving “interoceptively,” i.e. responding to internal state rather than to the environment, organisms can be robust to these organisational-transformations. We suggest that the robustness of interoceptive behaviour is due, in part, to the asymmetrical relationship between an organism and its environment, where the latter more substantially influences the former than vice versa. This relationship means that interoceptive behaviour can respond to the environment, the internal state and the interaction between the two, while exteroceptive behaviour can only respond to the environment. We discuss the possibilities that (i) interoceptive behaviour may play an important role of facilitating adaptive evolution (especially in the early evolution of primitive life) and (ii) interoceptive mechanisms could prove useful in efforts to create more robust synthetic life-forms. PMID:26743579

  2. A Dynamic Scheduling Method of Earth-Observing Satellites by Employing Rolling Horizon Strategy

    PubMed Central

    Dishan, Qiu; Chuan, He; Jin, Liu; Manhao, Ma

    2013-01-01

    Focused on the dynamic scheduling problem for earth-observing satellites (EOS), an integer programming model is constructed after analyzing the main constraints. The rolling horizon (RH) strategy is proposed according to the independent arriving time and deadline of the imaging tasks. This strategy is designed with a mixed triggering mode composed of periodical triggering and event triggering, and the scheduling horizon is decomposed into a series of static scheduling intervals. By optimizing the scheduling schemes in each interval, the dynamic scheduling of EOS is realized. We also propose three dynamic scheduling algorithms by the combination of the RH strategy and various heuristic algorithms. Finally, the scheduling results of different algorithms are compared and the presented methods in this paper are demonstrated to be efficient by extensive experiments. PMID:23690742

  3. A dynamic scheduling method of Earth-observing satellites by employing rolling horizon strategy.

    PubMed

    Dishan, Qiu; Chuan, He; Jin, Liu; Manhao, Ma

    2013-01-01

    Focused on the dynamic scheduling problem for earth-observing satellites (EOS), an integer programming model is constructed after analyzing the main constraints. The rolling horizon (RH) strategy is proposed according to the independent arriving time and deadline of the imaging tasks. This strategy is designed with a mixed triggering mode composed of periodical triggering and event triggering, and the scheduling horizon is decomposed into a series of static scheduling intervals. By optimizing the scheduling schemes in each interval, the dynamic scheduling of EOS is realized. We also propose three dynamic scheduling algorithms by the combination of the RH strategy and various heuristic algorithms. Finally, the scheduling results of different algorithms are compared and the presented methods in this paper are demonstrated to be efficient by extensive experiments.

  4. Assessment of the effectiveness of participatory developed adaptation strategies for HCMC

    NASA Astrophysics Data System (ADS)

    Lasage, R.; Veldkamp, T. I. E.; de Moel, H.; Van, T. C.; Phi, H. L.; Vellinga, P.; Aerts, J. C. J. H.

    2014-01-01

    Coastal cities are vulnerable to flooding, and flood risk to coastal cities will increase due to sea-level rise. Moreover, especially Asian cities are subject to considerable population growth and associated urban developments, increasing this risk even more. Empirical data on vulnerability and the cost and benefits of flood risk reducing measures are therefore paramount for sustainable development of these cities. This paper presents an approach to explore the impacts of sea level rise and socio-economic developments on flood risk for the flood prone District 4 in Ho Chi Minh City, Vietnam, and to develop and evaluate the effects of different adaptation strategies (new levees, dry- and wet flood proofing of buildings). A flood damage model was developed to simulate current and future flood risk using the results from a household survey to establish stage-damage curves for residential buildings. the model has been used to assess the effects of several participatory developed adaptation strategies to reduce flood risk, expressed in Expected Annual Damage (EAD). Adaptation strategies were evaluated assuming combinations of both sea level scenarios and land use scenarios. Together with information on costs of these strategies, we calculated the benefit-cost ratio and net present value for the adaptation strategies until 2100, taking into account depreciation rates of 2.5% and 5%. The results of this modeling study indicate that the current flood risk in District 4 is 0.31 million USD yr-1, increasing up to 0.78 million USD yr-1 in 2100. The net present value and benefit-cost ratios using a discount rate of 5% range from USD -107 to -1.5 million, and from 0.086 to 0.796 for the different strategies. Using a discount rate of 2.5% leads to an increase in both net present value and benefit cost ratio. The adaptation strategies wet proofing and dry proofing generate the best results using these economic indicators. The information on different strategies will be used by

  5. The strategies that peanut and nut-allergic consumers employ to remain safe when travelling abroad

    PubMed Central

    2012-01-01

    Background An understanding of the management strategies used by food allergic individuals is needed as a prerequisite to improving avoidance and enhancing quality of life. Travel abroad is a high risk time for severe and fatal food allergic reactions, but there is paucity of research concerning foreign travel. This study is the first to investigate the experiences of, and strategies used by peanut and tree nut allergic individuals when travelling abroad. Methods Thirty-two adults with a clinical history of reaction to peanuts or tree nuts consistent with IgE-mediated allergy participated in a qualitative interview study. Results Travel abroad was considered difficult with inherent risks for allergic individuals. Many participants recounted difficulties with airlines or restaurants. Inconsistency in managing allergen avoidance by airlines was a particular risk and a cause of frustration to participants. Individuals used a variety of strategies to remain safe including visiting familiar environments, limiting their activities, carrying allergy information cards in the host language, preparing their own food and staying close to medical facilities. Conclusions Participants used a variety of allergen avoidance strategies, which were mostly extensions or modifications of the strategies that they use when eating at home or eating-out in the UK. The extended strategies reflected their recognition of enhanced risk during travel abroad. Their risk assessments and actions were generally well informed and appropriate. A need for airline policy regarding allergy to be declared and adhered to is needed, as is more research to quantify the true risks of airborne allergens in the cabin. Recommendations arising from our study are presented. PMID:22776751

  6. Relationships among adaptive and maladaptive emotion regulation strategies and psychopathology during the treatment of comorbid anxiety and alcohol use disorders.

    PubMed

    Conklin, Laren R; Cassiello-Robbins, Clair; Brake, C Alex; Sauer-Zavala, Shannon; Farchione, Todd J; Ciraulo, Domenic A; Barlow, David H

    2015-10-01

    Both maladaptive and adaptive emotion regulation strategies have been linked with psychopathology. However, previous studies have largely examined them separately, and little research has examined the interplay of these strategies cross-sectionally or longitudinally in patients undergoing psychological treatment. This study examined the use and interplay of adaptive and maladaptive emotion regulation strategies in 81 patients receiving cognitive-behavioral interventions for comorbid alcohol use and anxiety disorders. Patients completed measures of emotion regulation strategy use and symptoms of psychopathology pre- and post-treatment. Cross-sectionally, higher use of maladaptive strategies (e.g., denial) was significantly related to higher psychopathology pre- and post-treatment, whereas higher use of adaptive strategies (e.g., acceptance) only significantly related to lower psychopathology post-treatment. Prospectively, changes in maladaptive strategies, but not changes in adaptive strategies, were significantly associated with post-treatment psychopathology. However, for patients with higher pre-treatment maladaptive strategy use, gains in adaptive strategies were significantly associated with lower post-treatment psychopathology. These findings suggest that psychological treatments may maximize efficacy by considering patient skill use at treatment outset. By better understanding a patient's initial emotion regulation skills, clinicians may be better able to optimize treatment outcomes by emphasizing maladaptive strategy use reduction predominately, or in conjunction with increasing adaptive skill use.

  7. Using a mini-Raman spectrometer to monitor the adaptive strategies of extremophile colonizers in arid deserts: relationships between signal strength, adaptive strategies, solar radiation, and humidity.

    PubMed

    Miralles, I; Jorge-Villar, S E; Cantón, Y; Domingo, F

    2012-08-01

    The survival strategies of one cyanobacteria colony and three terricolous lichen species from the hot subdesert of Tabernas, Spain, were studied along with topographical attributes of the area to investigate whether the protective strategies adopted by these pioneer soil colonizers are related to the environmental stressors under which they survive. A handheld Raman spectrometer was used for biomolecular characterization, while the microclimatic and topographic parameters were estimated with a Geographic Information System (GIS). We found that the survival strategies adopted by those organisms are based on different combinations of protective biomolecules, each with diverse ecophysiological functions, such as UV-radiation screening, free-energy quenching, antioxidants, and the production of different types and amounts of calcium oxalates. Our results show that the cyanobacteria community and each lichen species preferentially colonized a particular microhabitat with specific moisture and incident solar radiation levels and exhibited different adaptive mechanisms. In recent years, a number of studies have provided consistent results that suggest a link between the strategies adopted by those extremophile organisms and the microclimatic environmental parameters. To date, however, far too little attention has been paid to results from Raman analyses on dry specimens. Therefore, the results of the present study, produced with the use of our miniaturized instrument, will be of interest to future studies in astrobiology, especially due to the likely use of Raman spectroscopy at the surface of Mars.

  8. Repartnering and (Re)employment: Strategies to Cope with the Economic Consequences of Partnership Dissolution

    ERIC Educational Resources Information Center

    Jansen, Mieke; Mortelmans, Dimitri; Snoeckx, Laurent

    2009-01-01

    The economic consequences of a partnership dissolution have been described consistently in the research literature. For women all studies indicate severe financial losses, whereas men do not experience income decreases to the same extent. This article focuses on the 2 main strategies to cope with the economic consequences of a separation:…

  9. Taking "O" Level GCE Examinations: The Strategies Employed by Candidates and Their Teachers.

    ERIC Educational Resources Information Center

    Francis, J.C.

    1981-01-01

    Examines the relationship of study techniques and test-taking strategies to success on the "O" level of the British General Certificate of Education (GCE) examination. Findings showed that teachers and students felt that course reviews, including study of past examinations, was the best preparation. (AM)

  10. How Successful Learners Employ Learning Strategies in an EFL Setting in the Indonesian Context

    ERIC Educational Resources Information Center

    Setiyadi, Ag. Bambang; Sukirlan, Muhammad; Mahpul

    2016-01-01

    Numerous studies have been conducted to correlate the use of language learning strategies and language performance and the studies have contributed to different perspectives of teaching and learning a foreign language. Some studies have also revealed that the students learning a foreign language in Asian contexts have been proved to use different…

  11. An Action Research on Employing Constructivist Multi-Assessment Strategy in Teacher Education

    ERIC Educational Resources Information Center

    Gündogdu, Kerim

    2015-01-01

    The purpose of this study was to investigate the effectiveness of utilizing the multi-assessment strategy through a constructivist learning atmosphere with regard to perceptions of the pre-service teachers. The participants were 98 third year (junior) pre-service teachers attending to classroom management course in a public university in Turkey.…

  12. Frequency and perceived effectiveness of strategies to survive abuse employed by battered Mexican-origin women.

    PubMed

    Brabeck, Kalina M; Guzmán, Michele R

    2008-11-01

    This study documented the frequency and perceived effectiveness of battered Mexican-origin women's usage of formal and informal help and personal strategies to survive abuse. Semistructured interviews were conducted with 75 battered Mexican-origin women. Consistent with survivor theory, results indicated that participants sought help multiple times from several formal and informal help sources; some (i.e., shelter, family) were perceived more effective than others (i.e., lawyer, in-laws). Participants engaged in various personal strategies to survive abuse; some (i.e., using faith/religion) were rated more effective than others (i.e., placating the batterer). Responses to open-ended questions suggest why specific help sources and strategies were/were not effective and provide socioculturally specific suggestions for improving services. This study illuminates battered Mexican-origin women's strengths and barriers that impede their survival efforts. Contributions include focusing on a subset of battered Latinas and documenting the frequency and perceived effectiveness of a wide array of help sources and strategies.

  13. Classroom Interaction Strategies Employed by English Teachers at Lower Secondary Schools

    ERIC Educational Resources Information Center

    Suryati, Nunung

    2015-01-01

    This article reports a study on teachers' use of interaction strategies in English Language Teaching (ELT) in lower secondary level of education. The study involved eighteen teachers from Lower Secondary Schools in Malang, East Java. Classroom observation was selected as a method in this study by utilizing Self Evaluation Teacher Talk (SETT) as…

  14. Socio-economic vulnerability of coastal communities in southern Thailand: the development of adaptation strategies

    NASA Astrophysics Data System (ADS)

    Willroth, P.; Massmann, F.; Wehrhahn, R.; Revilla Diez, J.

    2012-08-01

    The tsunami of December 2004 impacted large areas of Thailand's coastline and caused severe human and economic losses. The recovery period revealed differences in the vulnerabilities of communities affected. An understanding of the causal factors of vulnerability is crucial for minimising the negative effects of future threats and developing adaptive capacities. This paper analyses the vulnerabilities and the development of adaptation strategies in the booming tourist area of Khao Lak and in the predominantly fishing and agricultural area of Ban Nam Khem through a comprehensive vulnerability framework. The results show that social networks played a crucial role in coping with the disaster. Social cohesion is important for strengthening the community and developing successful adaptation strategies. The development of tourism and the turning away from traditional activities have a significant positive influence on the income situation, but create a dependency on a single business sector. It could be shown that households generating their income in the tourism sector were vulnerable unless they had diversified their income previously. Income diversification decreased the vulnerability in the study areas. Adaptation strategies and processes developed in the aftermath clearly address these issues.

  15. Adaptive isogeometric analysis based on a combined r-h strategy

    NASA Astrophysics Data System (ADS)

    Basappa, Umesh; Rajagopal, Amirtham; Reddy, J. N.

    2016-03-01

    In the present work, an r-h adaptive isogeometric analysis is proposed for plane elasticity problems. For performing the r-adaption, the control net is considered to be a network of springs with the individual spring stiffness values being proportional to the error estimated at the control points. While preserving the boundary control points, relocation of only the interior control points is made by adopting a successive relaxation approach to achieve the equilibrium of spring system. To suit the noninterpolatory nature of the isogeometric approximation, a new point-wise error estimate for the h-refinement is proposed. To evaluate the point-wise error, hierarchical B-spline functions in Sobolev spaces are considered. The proposed adaptive h-refinement strategy is based on using De-Casteljau's algorithm for obtaining the new control points. The subsequent control meshes are thus obtained by using a recursive subdivision of reference control mesh. Such a strategy ensures that the control points lie in the physical domain in subsequent refinements, thus making the physical mesh to exactly interpolate the control mesh and thereby allowing the exact imposition of essential boundary conditions in the classical isogeometric analysis (IGA). The combined r-h adaptive refinement strategy results in better convergence characteristics with reduced errors than r- or h-refinement. Several numerical examples are presented to illustrate the efficiency of the proposed approach.

  16. Social and natural sciences differ in their research strategies, adapted to work for different knowledge landscapes.

    PubMed

    Jaffe, Klaus

    2014-01-01

    Do different fields of knowledge require different research strategies? A numerical model exploring different virtual knowledge landscapes, revealed two diverging optimal search strategies. Trend following is maximized when the popularity of new discoveries determine the number of individuals researching it. This strategy works best when many researchers explore few large areas of knowledge. In contrast, individuals or small groups of researchers are better in discovering small bits of information in dispersed knowledge landscapes. Bibliometric data of scientific publications showed a continuous bipolar distribution of these strategies, ranging from natural sciences, with highly cited publications in journals containing a large number of articles, to the social sciences, with rarely cited publications in many journals containing a small number of articles. The natural sciences seem to adapt their research strategies to landscapes with large concentrated knowledge clusters, whereas social sciences seem to have adapted to search in landscapes with many small isolated knowledge clusters. Similar bipolar distributions were obtained when comparing levels of insularity estimated by indicators of international collaboration and levels of country-self citations: researchers in academic areas with many journals such as social sciences, arts and humanities, were the most isolated, and that was true in different regions of the world. The work shows that quantitative measures estimating differences between academic disciplines improve our understanding of different research strategies, eventually helping interdisciplinary research and may be also help improve science policies worldwide.

  17. Social and Natural Sciences Differ in Their Research Strategies, Adapted to Work for Different Knowledge Landscapes

    PubMed Central

    Jaffe, Klaus

    2014-01-01

    Do different fields of knowledge require different research strategies? A numerical model exploring different virtual knowledge landscapes, revealed two diverging optimal search strategies. Trend following is maximized when the popularity of new discoveries determine the number of individuals researching it. This strategy works best when many researchers explore few large areas of knowledge. In contrast, individuals or small groups of researchers are better in discovering small bits of information in dispersed knowledge landscapes. Bibliometric data of scientific publications showed a continuous bipolar distribution of these strategies, ranging from natural sciences, with highly cited publications in journals containing a large number of articles, to the social sciences, with rarely cited publications in many journals containing a small number of articles. The natural sciences seem to adapt their research strategies to landscapes with large concentrated knowledge clusters, whereas social sciences seem to have adapted to search in landscapes with many small isolated knowledge clusters. Similar bipolar distributions were obtained when comparing levels of insularity estimated by indicators of international collaboration and levels of country-self citations: researchers in academic areas with many journals such as social sciences, arts and humanities, were the most isolated, and that was true in different regions of the world. The work shows that quantitative measures estimating differences between academic disciplines improve our understanding of different research strategies, eventually helping interdisciplinary research and may be also help improve science policies worldwide. PMID:25426723

  18. Cautious but Committed: Moving Toward Adaptive Planning and Operation Strategies for Renewable Energy's Wildlife Implications

    NASA Astrophysics Data System (ADS)

    Köppel, Johann; Dahmen, Marie; Helfrich, Jennifer; Schuster, Eva; Bulling, Lea

    2014-10-01

    Wildlife planning for renewable energy must cope with the uncertainties of potential wildlife impacts. Unfortunately, the environmental policies which instigate renewable energy and those which protect wildlife are not coherently aligned—creating a green versus green dilemma. Thus, climate mitigation efforts trigger renewable energy development, but then face substantial barriers from biodiversity protection instruments and practices. This article briefly reviews wind energy and wildlife interactions, highlighting the lively debated effects on bats. Today, planning and siting of renewable energy are guided by the precautionary principle in an attempt to carefully address wildlife challenges. However, this planning attitude creates limitations as it struggles to negotiate the aforementioned green versus green dilemma. More adaptive planning and management strategies and practices hold the potential to reconcile these discrepancies to some degree. This adaptive approach is discussed using facets of case studies from policy, planning, siting, and operational stages of wind energy in Germany and the United States, with one case showing adaptive planning in action for solar energy as well. This article attempts to highlight the benefits of more adaptive approaches as well as the possible shortcomings, such as reduced planning security for renewable energy developers. In conclusion, these studies show that adaptive planning and operation strategies can be designed to supplement and enhance the precautionary principle in wildlife planning for green energy.

  19. Urban Heat Island Adaptation Strategies are not created equal: Assessment of Impacts and Tradeoffs

    NASA Astrophysics Data System (ADS)

    Georgescu, Matei

    2014-05-01

    Sustainable urban expansion requires an extension of contemporary approaches that focus nearly exclusively on reduction of greenhouse gas emissions. Researchers have proposed biophysical approaches to urban heat island mitigation (e.g., via deployment of cool or green roofs) but little is known how these technologies vary with place and season and what impacts are beyond those of near surface temperature. Using a suite of continuous, multi-year and multi-member continental scale numerical simulations for the United States, we examine hydroclimatic impacts for a variety of U.S. urban expansion (to the year 2100) and urban adaptation futures and compare those to contemporary urban extent. Adaptation approaches include widespread adoption of cool roofs, green roofs, and a hypothetical hybrid approach integrating properties of both cool and green roofs (i.e., reflective green roofs). Widespread adoption of adaptation strategies exhibits hydroclimatic impacts that are regionally and seasonally dependent. For some regions and seasons, urban-induced warming of 3°C can be completely offset by the adaptation approaches examined. For other regions and seasons, widespread adoption of some adaptation strategies can result in significant reduction in precipitation. Finally, implications of large-scale urbanization for seasonal energy demand will be examined.

  20. Cautious but committed: moving toward adaptive planning and operation strategies for renewable energy's wildlife implications.

    PubMed

    Köppel, Johann; Dahmen, Marie; Helfrich, Jennifer; Schuster, Eva; Bulling, Lea

    2014-10-01

    Wildlife planning for renewable energy must cope with the uncertainties of potential wildlife impacts. Unfortunately, the environmental policies which instigate renewable energy and those which protect wildlife are not coherently aligned-creating a green versus green dilemma. Thus, climate mitigation efforts trigger renewable energy development, but then face substantial barriers from biodiversity protection instruments and practices. This article briefly reviews wind energy and wildlife interactions, highlighting the lively debated effects on bats. Today, planning and siting of renewable energy are guided by the precautionary principle in an attempt to carefully address wildlife challenges. However, this planning attitude creates limitations as it struggles to negotiate the aforementioned green versus green dilemma. More adaptive planning and management strategies and practices hold the potential to reconcile these discrepancies to some degree. This adaptive approach is discussed using facets of case studies from policy, planning, siting, and operational stages of wind energy in Germany and the United States, with one case showing adaptive planning in action for solar energy as well. This article attempts to highlight the benefits of more adaptive approaches as well as the possible shortcomings, such as reduced planning security for renewable energy developers. In conclusion, these studies show that adaptive planning and operation strategies can be designed to supplement and enhance the precautionary principle in wildlife planning for green energy.

  1. Strategies for adding adaptive learning mechanisms to rule-based diagnostic expert systems

    NASA Technical Reports Server (NTRS)

    Stclair, D. C.; Sabharwal, C. L.; Bond, W. E.; Hacke, Keith

    1988-01-01

    Rule-based diagnostic expert systems can be used to perform many of the diagnostic chores necessary in today's complex space systems. These expert systems typically take a set of symptoms as input and produce diagnostic advice as output. The primary objective of such expert systems is to provide accurate and comprehensive advice which can be used to help return the space system in question to nominal operation. The development and maintenance of diagnostic expert systems is time and labor intensive since the services of both knowledge engineer(s) and domain expert(s) are required. The use of adaptive learning mechanisms to increment evaluate and refine rules promises to reduce both time and labor costs associated with such systems. This paper describes the basic adaptive learning mechanisms of strengthening, weakening, generalization, discrimination, and discovery. Next basic strategies are discussed for adding these learning mechanisms to rule-based diagnostic expert systems. These strategies support the incremental evaluation and refinement of rules in the knowledge base by comparing the set of advice given by the expert system (A) with the correct diagnosis (C). Techniques are described for selecting those rules in the in the knowledge base which should participate in adaptive learning. The strategies presented may be used with a wide variety of learning algorithms. Further, these strategies are applicable to a large number of rule-based diagnostic expert systems. They may be used to provide either immediate or deferred updating of the knowledge base.

  2. A review of climate-change adaptation strategies for wildlife management and biodiversity conservation.

    PubMed

    Mawdsley, Jonathan R; O'Malley, Robin; Ojima, Dennis S

    2009-10-01

    The scientific literature contains numerous descriptions of observed and potential effects of global climate change on species and ecosystems. In response to anticipated effects of climate change, conservation organizations and government agencies are developing "adaptation strategies" to facilitate the adjustment of human society and ecological systems to altered climate regimes. We reviewed the literature and climate-change adaptation plans that have been developed in United States, Canada, England, México, and South Africa and found 16 general adaptation strategies that relate directly to the conservation of biological diversity. These strategies can be grouped into four broad categories: land and water protection and management; direct species management; monitoring and planning; and law and policy. Tools for implementing these strategies are similar or identical to those already in use by conservationists worldwide (land and water conservation, ecological restoration, agrienvironment schemes, species translocation, captive propagation, monitoring, natural resource planning, and legislation/regulation). Although our review indicates natural resource managers already have many tools that can be used to address climate-change effects, managers will likely need to apply these tools in novel and innovative ways to meet the unprecedented challenges posed by climate change.

  3. Managing for Climate Change in Western Forest Ecosystems; The Role of Refugia in Adaptation Strategies (Invited)

    NASA Astrophysics Data System (ADS)

    Millar, C. I.; Morelli, T.

    2009-12-01

    Managing forested ecosystems in western North America for adaptation to climate change involves options that depend on resource objectives, landscape conditions, sensitivity to change, and social desires. Strategies range from preserving species and ecosystems in the face of change (resisting change); managing for resilience to change; realigning ecosystems that have been severely altered so that they can adapt successfully; and enabling species to respond to climate changes. We are exploring one extreme in this range of strategies, that is, to manage locations, species, communities, or ecosystems as refugia. This concept is familiar from the Quaternary literature as isolated locations where climates remained warm during cold glacial intervals and wherein species contracted and persisted in small populations. References to refugia have been made in the climate-adaptation literature but little elaborated, and applications have not been described. We are addressing this gap conceptually and in case-studies from national forest and national park environments in California. Using a classification of refugium categories, we extend the concept beyond the original use to include diverse locations and conditions where plant or animal species, or ecosystems of concern, would persist during future changing climatic backgrounds. These locations may be determined as refugial for reasons of local microclimate, substrate, elevation, topographic context, paleohistory, species ecology, or management capacity. Recognizing that species and ecosystems respond to climate change differently, refugium strategies are appropriate in some situations and not others. We describe favorable conditions for using refugium strategies and elaborate specific approaches in Sierra Nevada case studies.

  4. General Signal Amplification Strategy for Nonfaradic Impedimetric Sensing: Trastuzumab Detection Employing a Peptide Immunosensor.

    PubMed

    Liu, Juan; Chisti, Mohammad Muhsin; Zeng, Xiangqun

    2017-04-04

    A label-free and reagent-free peptide mimotope capacitive biosensor has been developed for cancer drug (trastuzumab) quantification based on nonfaradic readout. The low sensitivity issue of capacitive biosensors was overcome with two innovations: peptide mimotope mixed self-assembled monolayer (SAM) biointerface and dilution of the analysis buffer. Signal amplification was achieved through dilution of phosphate-buffered saline (PBS) to tune Cdl to dominate the overall capacitance change upon target binding, which contribution is often negligible without dilution. After 1000× dilution, the limit of detection was lowered 500-fold (0.22 μg/mL) and the sensitivity was increased 20-fold [0.04192 (μg/mL)(-1)] in comparison with undiluted PBS. The proposed signal amplification strategy is more straightforward and practical compared to biorecognition element engineering and other strategies. The proposed method was further applied to planar electrodes for optimizing sensing response time to less than 1 min.

  5. Employing U.S. SOF in Colombia: Updating Strategy to Achieve The Desired End State

    DTIC Science & Technology

    2006-05-31

    APPLICABLE HISTORIC LESSONS LEARNED 11 CONCLUSION 14 ENDNOTES 15 BIBLIOGRAPHY 18 1 INTRODUCTION For nearly the past four decades, Colombia has...by Defense Secretary Donald Rumsfeld, a strategy that involves training host nation (HN) forces in counter-insurgency operations.4 Lessons learned ...worry about. APPLICABLE HISTORIC LESSONS LEARNED One of the most obvious “Lessons Learned ” demonstrated by our counter-insurgency experiences in Vietnam

  6. Bone Microstructure of the Stereospondyl Lydekkerina Huxleyi Reveals Adaptive Strategies to the Harsh Post Permian-Extinction Environment.

    PubMed

    Canoville, Aurore; Chinsamy, Anusuya

    2015-07-01

    The small-bodied stereospondyl Lydekkerina huxleyi, dominated the amphibian fauna of the South African Lower Triassic. Even though the anatomy of this amphibian has been well described, its growth strategies and lifestyle habits have remained controversial. Previous studies attributed the relative uniformity in skull sizes to a predominance of subadult and adult specimens recovered in the fossil record. Anatomical and taphonomic data suggested that the relatively small body-size of this genus, as compared to its Permo-Triassic relatives, could be linked to a shortened, rapid developmental period as an adaptation to maintain successful breeding populations under harsh environmental conditions. Moreover, Lydekkerina's habitat has been hypothesized to be either aquatic or mainly terrestrial. The current study, utilizes bone microstructure to reassess previous hypotheses pertaining to the biology and ecology of Lydekkerina. Various skeletal elements of different-sized specimens are analyzed to understand its growth dynamics, intraskeletal variability, and lifestyle adaptations. Bone histology revealed that our sample comprises individuals at different ontogenetic stages i.e., juveniles to mature individuals. Our results show that these amphibians, despite exhibiting plasticity in growth, experienced an overall faster growth during early ontogeny (thereby attaining sexual maturity sooner), as compared to most other temnospondyls. The microanatomy of the long bones with their thick bone walls and distinctive medullary cavity suggests that Lydekkerina may have been amphibious with a tendency to be more terrestrial. Our study concludes that Lydekkerina employed a peculiar growth strategy and lifestyle adaptations, which enabled it to endure the harsh, dry conditions of the Early Triassic.

  7. Adaptive and maladaptive emotion regulation strategies: interactive effects during CBT for social anxiety disorder.

    PubMed

    Aldao, Amelia; Jazaieri, Hooria; Goldin, Philippe R; Gross, James J

    2014-05-01

    There has been a increasing interest in understanding emotion regulation deficits in social anxiety disorder (SAD; e.g., Hofmann, Sawyer, Fang, & Asnaani, 2012). However, much remains to be understood about the patterns of associations among regulation strategies in the repertoire. Doing so is important in light of the growing recognition that people's ability to flexibly implement strategies is associated with better mental health (e.g., Kashdan et al., 2014). Based on previous work (Aldao & Nolen-Hoeksema, 2012), we examined whether putatively adaptive and maladaptive emotion regulation strategies interacted with each other in the prediction of social anxiety symptoms in a sample of 71 participants undergoing CBT for SAD. We found that strategies interacted with each other and that this interaction was qualified by a three-way interaction with a contextual factor, namely treatment study phase. Consequently, these findings underscore the importance of modeling contextual factors when seeking to understand emotion regulation deficits in SAD.

  8. Nutritional strategies to support adaptation to high-intensity interval training in team sports.

    PubMed

    Gibala, Martin J

    2013-01-01

    Team sports are characterized by intermittent high-intensity activity patterns. Typically, play consists of short periods of very intense or all-out efforts interspersed with longer periods of low-intensity activity. Fatigue is a complex, multi-factorial process, but intense intermittent exercise performance can potentially be limited by reduced availability of substrates stored in skeletal muscle and/or metabolic by-products associated with fuel breakdown. High-intensity interval training (HIT) has been shown to induce adaptations in skeletal muscle that enhance the capacity for both oxidative and non-oxidative metabolism. Nutrient availability is a potent modulator of many acute physiological responses to exercise, including various molecular signaling pathways that are believed to regulate cellular adaptation to training. Several nutritional strategies have also been reported to acutely alter metabolism and enhance intermittent high-intensity exercise performance. However, relatively little is known regarding the effect of chronic interventions, and whether supplementation over a period of weeks or months augments HIT-induced physiological remodeling and promotes greater performance adaptations. Theoretically, a nutritional intervention could augment HIT adaptation by improving energy metabolism during exercise, which could facilitate greater total work and an enhanced chronic training stimulus, or promoting some aspect of the adaptive response during recovery, which could lead to enhanced physiological adaptations over time.

  9. The diversity of gendered adaptation strategies to climate change of Indian farmers: A feminist intersectional approach.

    PubMed

    Ravera, Federica; Martín-López, Berta; Pascual, Unai; Drucker, Adam

    2016-12-01

    This paper examines climate change adaptation and gender issues through an application of a feminist intersectional approach. This approach permits the identification of diverse adaptation responses arising from the existence of multiple and fragmented dimensions of identity (including gender) that intersect with power relations to shape situation-specific interactions between farmers and ecosystems. Based on results from contrasting research cases in Bihar and Uttarakhand, India, this paper demonstrates, inter alia, that there are geographically determined gendered preferences and adoption strategies regarding adaptation options and that these are influenced by the socio-ecological context and institutional dynamics. Intersecting identities, such as caste, wealth, age and gender, influence decisions and reveal power dynamics and negotiation within the household and the community, as well as barriers to adaptation among groups. Overall, the findings suggest that a feminist intersectional approach does appear to be useful and worth further exploration in the context of climate change adaptation. In particular, future research could benefit from more emphasis on a nuanced analysis of the intra-gender differences that shape adaptive capacity to climate change.

  10. Older adults employ alternative strategies to operate within their maximum capabilities when ascending stairs.

    PubMed

    Reeves, N D; Spanjaard, M; Mohagheghi, A A; Baltzopoulos, V; Maganaris, C N

    2009-04-01

    Older people may operate much closer to their maximum capabilities than young adults when ascending stairs due to their lower maximum musculoskeletal capabilities. The purpose of this study was to establish the joint moment and range of motion demands of stair ascent relative to maximum capabilities in elderly and young adults. Fifteen elderly (mean age 75 years) and 17 young adult (mean age 25 years) participants ascended a purpose-built 4-step staircase with force platforms embedded into the steps and kinematic data was acquired using motion capture. Maximum musculoskeletal capabilities were assessed using a dynamometer. This study showed for the first time that stair ascent approaches the joint moment limits at the ankle in both young and older participants ( approximately 90%). One of the most important and novel findings of this study was that elderly people were only capable of meeting the high demands by adopting a number of alternative strategies not observed in young adults: (i) applying the joint moments differently than young adults across the knee and ankle, (ii) translocating energy from the knee to the ankle, thereby enhancing the ankle joint moment upon maximum demand and (iii) by enabling the plantarflexors to act over a more favourable portion of the moment-angle relation upon maximum ankle joint moment demand. The elderly displayed a more cautious strategy to optimize positional stability during stair ascent, by maintaining a smaller separation between the centre of mass and centre of pressure in the frontal plane. It seems that elderly people may meet the demands of unaided stair ascent by adopting a number of alternative strategies to compensate for their reduced musculoskeletal capabilities.

  11. Taking the pulse of personalized and online employee communication strategies: the second annual survey of major employer trends.

    PubMed

    Kolman, S

    2001-03-01

    In their efforts to build workforce commitment, many employers are using personalized communication to reach out to employees. Benefacts, the personalized communication service of Aon Consulting, recently surveyed employers nationwide regarding their uses of personalized communication, especially in the online environment. The survey looked at organizations' current online and print communication strategies as well as their future plans. This article describes the needs of employees to understand organizational purpose and to find a balance between work and their personal lives. This examination of the uses of personalized communication to meet these needs and the analysis of current industry trends will help benefit professionals focus on their own communication plans as they strive to meet the challenges of today's workforce.

  12. Psychrophilic yeasts from worldwide glacial habitats: diversity, adaptation strategies and biotechnological potential.

    PubMed

    Buzzini, Pietro; Branda, Eva; Goretti, Marta; Turchetti, Benedetta

    2012-11-01

    Glacial habitats (cryosphere) include some of the largest unexplored and extreme biospheres on Earth. These habitats harbor a wide diversity of psychrophilic prokaryotic and eukaryotic microorganisms. These highly specialized microorganisms have developed adaptation strategies to overcome the direct and indirect life-endangering influence of low temperatures. For many years Antarctica has been the geographic area preferred by microbiologists for studying the diversity of psychrophilic microorganisms (including yeasts). However, there have been an increasing number of studies on psychrophilic yeasts sharing the non-Antarctic cryosphere. The present paper provides an overview of the distribution and adaptation strategies of psychrophilic yeasts worldwide. Attention is also focused on their biotechnological potential, especially on their exploitation as a source of cold-active enzymes and for bioremediation purposes.

  13. Adaptive Immune Regulation of Glial Homeostasis as an Immunization Strategy for Neurodegenerative Diseases

    PubMed Central

    Kosloski, Lisa M.; Ha, Duy M.; Stone, David K.; Hutter, Jessica A. L.; Pichler, Michael R.; Reynolds, Ashley D.; Gendelman, Howard E.; Mosley, R. Lee

    2010-01-01

    Neurodegenerative diseases, notably Alzheimer's and Parkinson's diseases, are amongst the most devastating disorders afflicting the elderly. Currently, no curative treatments or treatments that interdict disease progression exist. Over the past decade, immunization strategies have been proposed to combat disease progression. Such strategies induce humoral immune responses against misfolded protein aggregates to facilitate their clearance. Robust adaptive immunity against misfolded proteins, however, accelerates disease progression, precipitated by induced effector T cell responses that lead to encephalitis and neuronal death. Since then, mechanisms that attenuate such adaptive neurotoxic immune responses have been sought. We propose that shifting the balance between effector and regulatory T cell activity can attenuate neurotoxic inflammatory events. This review summarizes advances in immune regulation to achieve a homeostatic glial response for therapeutic gain. Promising new ways to optimize immunization schemes and measure their clinical efficacy are also discussed. PMID:20524958

  14. Finite element/finite volume approaches with adaptive time stepping strategies for transient thermal problems

    NASA Technical Reports Server (NTRS)

    Mohan, Ram V.; Tamma, Kumar K.

    1993-01-01

    An adaptive time stepping strategy for transient thermal analysis of engineering systems is described which computes the time step based on the local truncation error with a good global error control and obtains optimal time steps to be used during the analysis. Combined mesh partitionings involving FEM/FVM meshes based on physical situations to obtain numerically improved physical representations are also proposed. Numerical test cases are described and comparative pros and cons are identified for practical situations.

  15. Invasion strategies in clonal aquatic plants: are phenotypic differences caused by phenotypic plasticity or local adaptation?

    PubMed Central

    Riis, Tenna; Lambertini, Carla; Olesen, Birgit; Clayton, John S.; Brix, Hans; Sorrell, Brian K.

    2010-01-01

    Background and Aims The successful spread of invasive plants in new environments is often linked to multiple introductions and a diverse gene pool that facilitates local adaptation to variable environmental conditions. For clonal plants, however, phenotypic plasticity may be equally important. Here the primary adaptive strategy in three non-native, clonally reproducing macrophytes (Egeria densa, Elodea canadensis and Lagarosiphon major) in New Zealand freshwaters were examined and an attempt was made to link observed differences in plant morphology to local variation in habitat conditions. Methods Field populations with a large phenotypic variety were sampled in a range of lakes and streams with different chemical and physical properties. The phenotypic plasticity of the species before and after cultivation was studied in a common garden growth experiment, and the genetic diversity of these same populations was also quantified. Key Results For all three species, greater variation in plant characteristics was found before they were grown in standardized conditions. Moreover, field populations displayed remarkably little genetic variation and there was little interaction between habitat conditions and plant morphological characteristics. Conclusions The results indicate that at the current stage of spread into New Zealand, the primary adaptive strategy of these three invasive macrophytes is phenotypic plasticity. However, while limited, the possibility that genetic diversity between populations may facilitate ecotypic differentiation in the future cannot be excluded. These results thus indicate that invasive clonal aquatic plants adapt to new introduced areas by phenotypic plasticity. Inorganic carbon, nitrogen and phosphorous were important in controlling plant size of E. canadensis and L. major, but no other relationships between plant characteristics and habitat conditions were apparent. This implies that within-species differences in plant size can be explained

  16. Hybrid Self-Adaptive Evolution Strategies Guided by Neighborhood Structures for Combinatorial Optimization Problems.

    PubMed

    Coelho, V N; Coelho, I M; Souza, M J F; Oliveira, T A; Cota, L P; Haddad, M N; Mladenovic, N; Silva, R C P; Guimarães, F G

    2016-01-01

    This article presents an Evolution Strategy (ES)--based algorithm, designed to self-adapt its mutation operators, guiding the search into the solution space using a Self-Adaptive Reduced Variable Neighborhood Search procedure. In view of the specific local search operators for each individual, the proposed population-based approach also fits into the context of the Memetic Algorithms. The proposed variant uses the Greedy Randomized Adaptive Search Procedure with different greedy parameters for generating its initial population, providing an interesting exploration-exploitation balance. To validate the proposal, this framework is applied to solve three different [Formula: see text]-Hard combinatorial optimization problems: an Open-Pit-Mining Operational Planning Problem with dynamic allocation of trucks, an Unrelated Parallel Machine Scheduling Problem with Setup Times, and the calibration of a hybrid fuzzy model for Short-Term Load Forecasting. Computational results point out the convergence of the proposed model and highlight its ability in combining the application of move operations from distinct neighborhood structures along the optimization. The results gathered and reported in this article represent a collective evidence of the performance of the method in challenging combinatorial optimization problems from different application domains. The proposed evolution strategy demonstrates an ability of adapting the strength of the mutation disturbance during the generations of its evolution process. The effectiveness of the proposal motivates the application of this novel evolutionary framework for solving other combinatorial optimization problems.

  17. Adaptive governance and institutional strategies for climate-induced community relocations in Alaska

    PubMed Central

    Bronen, Robin; Chapin, F. Stuart

    2013-01-01

    This article presents governance and institutional strategies for climate-induced community relocations. In Alaska, repeated extreme weather events coupled with climate change-induced coastal erosion impact the habitability of entire communities. Community residents and government agencies concur that relocation is the only adaptation strategy that can protect lives and infrastructure. Community relocation stretches the financial and institutional capacity of existing governance institutions. Based on a comparative analysis of three Alaskan communities, Kivalina, Newtok, and Shishmaref, which have chosen to relocate, we examine the institutional constraints to relocation in the United States. We identify policy changes and components of a toolkit that can facilitate community-based adaptation when environmental events threaten people’s lives and protection in place is not possible. Policy changes include amendment of the Stafford Act to include gradual geophysical processes, such as erosion, in the statutory definition of disaster and the creation of an adaptive governance framework to allow communities a continuum of responses from protection in place to community relocation. Key components of the toolkit are local leadership and integration of social and ecological well-being into adaptation planning. PMID:23690592

  18. A spatial explicit strategy reduces error but interferes with sensorimotor adaptation

    PubMed Central

    Benson, Bryan L.; Anguera, Joaquin A.

    2011-01-01

    Although sensorimotor adaptation is typically thought of as an implicit form of learning, it has been shown that participants who gain explicit awareness of the nature of the perturbation during adaptation exhibit more learning than those who do not. With rare exceptions, however, explicit awareness is typically polled at the end of the study. Here, we provided participants with either an explicit spatial strategy or no instructions before learning. Early in learning, explicit instructions greatly reduced movement errors but also resulted in increased trial-to-trial variability and longer reaction times. Late in adaptation, performance was indistinguishable between the explicit and implicit groups, but the mechanisms underlying performance improvements remained fundamentally different, as revealed by catch trials. The progression of implicit recalibration in the explicit group was modulated by the use of an explicit strategy: these participants showed a lower level of recalibration as well as decreased aftereffects. This phenomenon may be due to the reduced magnitude of errors made to the target during adaptation or inhibition of implicit learning mechanisms by explicit processing. PMID:21451054

  19. Adaptive governance and institutional strategies for climate-induced community relocations in Alaska.

    PubMed

    Bronen, Robin; Chapin, F Stuart

    2013-06-04

    This article presents governance and institutional strategies for climate-induced community relocations. In Alaska, repeated extreme weather events coupled with climate change-induced coastal erosion impact the habitability of entire communities. Community residents and government agencies concur that relocation is the only adaptation strategy that can protect lives and infrastructure. Community relocation stretches the financial and institutional capacity of existing governance institutions. Based on a comparative analysis of three Alaskan communities, Kivalina, Newtok, and Shishmaref, which have chosen to relocate, we examine the institutional constraints to relocation in the United States. We identify policy changes and components of a toolkit that can facilitate community-based adaptation when environmental events threaten people's lives and protection in place is not possible. Policy changes include amendment of the Stafford Act to include gradual geophysical processes, such as erosion, in the statutory definition of disaster and the creation of an adaptive governance framework to allow communities a continuum of responses from protection in place to community relocation. Key components of the toolkit are local leadership and integration of social and ecological well-being into adaptation planning.

  20. Farmers' Perceptions of Climate Change and Agricultural Adaptation Strategies in Rural Sahel

    NASA Astrophysics Data System (ADS)

    Mertz, Ole; Mbow, Cheikh; Reenberg, Anette; Diouf, Awa

    2009-05-01

    Farmers in the Sahel have always been facing climatic variability at intra- and inter-annual and decadal time scales. While coping and adaptation strategies have traditionally included crop diversification, mobility, livelihood diversification, and migration, singling out climate as a direct driver of changes is not so simple. Using focus group interviews and a household survey, this study analyzes the perceptions of climate change and the strategies for coping and adaptation by sedentary farmers in the savanna zone of central Senegal. Households are aware of climate variability and identify wind and occasional excess rainfall as the most destructive climate factors. Households attribute poor livestock health, reduced crop yields and a range of other problems to climate factors, especially wind. However, when questions on land use and livelihood change are not asked directly in a climate context, households and groups assign economic, political, and social rather than climate factors as the main reasons for change. It is concluded that the communities studied have a high awareness of climate issues, but climatic narratives are likely to influence responses when questions mention climate. Change in land use and livelihood strategies is driven by adaptation to a range of factors of which climate appears not to be the most important. Implications for policy-making on agricultural and economic development will be to focus on providing flexible options rather than specific solutions to uncertain climate.

  1. Farmers' perceptions of climate change and agricultural adaptation strategies in rural Sahel.

    PubMed

    Mertz, Ole; Mbow, Cheikh; Reenberg, Anette; Diouf, Awa

    2009-05-01

    Farmers in the Sahel have always been facing climatic variability at intra- and inter-annual and decadal time scales. While coping and adaptation strategies have traditionally included crop diversification, mobility, livelihood diversification, and migration, singling out climate as a direct driver of changes is not so simple. Using focus group interviews and a household survey, this study analyzes the perceptions of climate change and the strategies for coping and adaptation by sedentary farmers in the savanna zone of central Senegal. Households are aware of climate variability and identify wind and occasional excess rainfall as the most destructive climate factors. Households attribute poor livestock health, reduced crop yields and a range of other problems to climate factors, especially wind. However, when questions on land use and livelihood change are not asked directly in a climate context, households and groups assign economic, political, and social rather than climate factors as the main reasons for change. It is concluded that the communities studied have a high awareness of climate issues, but climatic narratives are likely to influence responses when questions mention climate. Change in land use and livelihood strategies is driven by adaptation to a range of factors of which climate appears not to be the most important. Implications for policy-making on agricultural and economic development will be to focus on providing flexible options rather than specific solutions to uncertain climate.

  2. Preliminary design of ultra-long cycle fast reactor employing breed-and-burn strategy

    SciTech Connect

    Tak, T. W.; Yu, H.; Kim, J. H.; Lee, D.; Kim, T. K.

    2012-07-01

    A new design of ultra-long cycle fast reactor with power rate of 1000 MWe (UCFR) has been developed based on the strategy of breed-and burn. The bottom region of the core with low enriched uranium (LEU) plays a role of igniter of the core burning and the upper natural uranium (NU) region acts as blanket for breeding. Fissile materials are bred in the blanket and the active core moves upward at a speed of 5.4 cm/year. Through the core depletion calculation using Monte Carlo code, McCARD, it is confirmed that a full power operation of 60 years without refueling is feasible. Core performance characteristics have been evaluated in terms of axial/radial power shapes, reactivity feedback coefficients, etc. This design will serve as a base model for further design study of UCFRs using LWR spent fuels in the blanket region. (authors)

  3. Multi-type Childhood Abuse, Strategies of Coping, and Psychological Adaptations in Young Adults

    PubMed Central

    Sesar, Kristina; Šimić, Nataša; Barišić, Marijana

    2010-01-01

    Aim To retrospectively analyze the rate of multi-type abuse in childhood and the effects of childhood abuse and type of coping strategies on the psychological adaptation of young adults in a sample form the student population of the University of Mostar. Methods The study was conducted on a convenience sample of 233 students from the University of Mostar (196 female and 37 male), with a median age of 20 (interquartile range, 2). Exposure to abuse was determined using the Child Maltreatment Scales for Adults, which assesses emotional, physical, and sexual abuse, neglect, and witnessing family violence. Psychological adaptation was explored by the Trauma Symptom Checklist, which assesses anxiety/depression, sexual problems, trauma symptoms, and somatic symptoms. Strategies of coping with stress were explored by the Coping Inventory for Stressful Situations. Results Multi-type abuse in childhood was experienced by 172 participants (74%) and all types of abuse by 11 (5%) participants. Emotional and physical maltreatment were the most frequent types of abuse and mostly occurred together with other types of abuse. Significant association was found between all types of abuse (r = 0.436-0.778, P < 0.050). Exposure to sexual abuse in childhood and coping strategies were significant predictors of anxiety/depression (R2 = 0.3553), traumatic symptoms (R2 = 0.2299), somatic symptoms (R2 = 0.2173), and sexual problems (R2 = 0.1550, P < 0.001). Conclusion Exposure to multi-type abuse in childhood is a traumatic experience with long-term negative effects. Problem-oriented coping strategies ensure a better psychosocial adaptation than emotion-oriented strategies. PMID:20960590

  4. Climate change and eHealth: a promising strategy for health sector mitigation and adaptation

    PubMed Central

    Holmner, Åsa; Rocklöv, Joacim; Ng, Nawi; Nilsson, Maria

    2012-01-01

    Climate change is one of today's most pressing global issues. Policies to guide mitigation and adaptation are needed to avoid the devastating impacts of climate change. The health sector is a significant contributor to greenhouse gas emissions in developed countries, and its climate impact in low-income countries is growing steadily. This paper reviews and discusses the literature regarding health sector mitigation potential, known and hypothetical co-benefits, and the potential of health information technology, such as eHealth, in climate change mitigation and adaptation. The promising role of eHealth as an adaptation strategy to reduce societal vulnerability to climate change, and the link's between mitigation and adaptation, are also discussed. The topic of environmental eHealth has gained little attention to date, despite its potential to contribute to more sustainable and green health care. A growing number of local and global initiatives on ‘green information and communication technology (ICT)’ are now mentioning eHealth as a promising technology with the potential to reduce emission rates from ICT use. However, the embracing of eHealth is slow because of limitations in technological infrastructure, capacity and political will. Further research on potential emissions reductions and co-benefits with green ICT, in terms of health outcomes and economic effectiveness, would be valuable to guide development and implementation of eHealth in health sector mitigation and adaptation policies. PMID:22679398

  5. Climate change and eHealth: a promising strategy for health sector mitigation and adaptation.

    PubMed

    Holmner, Asa; Rocklöv, Joacim; Ng, Nawi; Nilsson, Maria

    2012-01-01

    Climate change is one of today's most pressing global issues. Policies to guide mitigation and adaptation are needed to avoid the devastating impacts of climate change. The health sector is a significant contributor to greenhouse gas emissions in developed countries, and its climate impact in low-income countries is growing steadily. This paper reviews and discusses the literature regarding health sector mitigation potential, known and hypothetical co-benefits, and the potential of health information technology, such as eHealth, in climate change mitigation and adaptation. The promising role of eHealth as an adaptation strategy to reduce societal vulnerability to climate change, and the link's between mitigation and adaptation, are also discussed. The topic of environmental eHealth has gained little attention to date, despite its potential to contribute to more sustainable and green health care. A growing number of local and global initiatives on 'green information and communication technology (ICT)' are now mentioning eHealth as a promising technology with the potential to reduce emission rates from ICT use. However, the embracing of eHealth is slow because of limitations in technological infrastructure, capacity and political will. Further research on potential emissions reductions and co-benefits with green ICT, in terms of health outcomes and economic effectiveness, would be valuable to guide development and implementation of eHealth in health sector mitigation and adaptation policies.

  6. Photosynthetic adaptation strategy of Ulva prolifera floating on the sea surface to environmental changes.

    PubMed

    Zhao, Xinyu; Tang, Xuexi; Zhang, Huanxin; Qu, Tongfei; Wang, Ying

    2016-10-01

    For 8 consecutive years, a green tide has originated in the southern Yellow Sea and spread to the Qingdao offshore area. The causative species, Ulva prolifera, always forms a very thick thallus mat that is capable of drifting long distances over long periods. During this process, although the thalli face disturbance by complex environmental factors, they maintain high biomass and proliferation. We hypothesized that some form of photosynthetic adaptation strategy must exist to protect the thalli. Therefore, we studied the different photosynthetic response characteristics of the surface and lower layers of the floating thallus mats, and investigated the physiological and molecular-level adaptation mechanisms. The results showed that: (1) U. prolifera has strong photosynthetic capability that ensures it can gain sufficient energy to increase its biomass and adapt to long-distance migration. (2) Surface layer thalli adapt to the complex environment by dissipating excess energy via photosynthetic quantum control (energy quenching and energy redistribution between PSII/PSI) to avoid irreversible damage to the photosynthetic system. (3) Lower layer thalli increase their contents of Chlorophyll a (Chl a) and Chlorophyll b (Chl b) and decrease their Chl a/Chl b ratio to improve their ability to use light energy. (4) U. prolifera has strong photosynthetic plasticity and can adapt to frequent exchange between the surface and lower layer environments because of wave disturbance. Pigment component changes, energy quenching, and energy redistribution between PSII/PSI contribute to this photosynthetic plasticity.

  7. The New Weather Radar for America's Space Program in Florida: A Temperature Profile Adaptive Scan Strategy

    NASA Technical Reports Server (NTRS)

    Carey, L. D.; Petersen, W. A.; Deierling, W.; Roeder, W. P.

    2009-01-01

    A new weather radar is being acquired for use in support of America s space program at Cape Canaveral Air Force Station, NASA Kennedy Space Center, and Patrick AFB on the east coast of central Florida. This new radar replaces the modified WSR-74C at Patrick AFB that has been in use since 1984. The new radar is a Radtec TDR 43-250, which has Doppler and dual polarization capability. A new fixed scan strategy was designed to best support the space program. The fixed scan strategy represents a complex compromise between many competing factors and relies on climatological heights of various temperatures that are important for improved lightning forecasting and evaluation of Lightning Launch Commit Criteria (LCC), which are the weather rules to avoid lightning strikes to in-flight rockets. The 0 C to -20 C layer is vital since most generation of electric charge occurs within it and so it is critical in evaluating Lightning LCC and in forecasting lightning. These are two of the most important duties of 45 WS. While the fixed scan strategy that covers most of the climatological variation of the 0 C to -20 C levels with high resolution ensures that these critical temperatures are well covered most of the time, it also means that on any particular day the radar is spending precious time scanning at angles covering less important heights. The goal of this project is to develop a user-friendly, Interactive Data Language (IDL) computer program that will automatically generate optimized radar scan strategies that adapt to user input of the temperature profile and other important parameters. By using only the required scan angles output by the temperature profile adaptive scan strategy program, faster update times for volume scans and/or collection of more samples per gate for better data quality is possible, while maintaining high resolution at the critical temperature levels. The temperature profile adaptive technique will also take into account earth curvature and refraction

  8. A global logrank test for adaptive treatment strategies based on observational studies.

    PubMed

    Li, Zhiguo; Valenstein, Marcia; Pfeiffer, Paul; Ganoczy, Dara

    2014-02-28

    In studying adaptive treatment strategies, a natural question that is of paramount interest is whether there is any significant difference among all possible treatment strategies. When the outcome variable of interest is time-to-event, we propose an inverse probability weighted logrank test for testing the equivalence of a fixed set of pre-specified adaptive treatment strategies based on data from an observational study. The weights take into account both the possible selection bias in an observational study and the fact that the same subject may be consistent with more than one treatment strategy. The asymptotic distribution of the weighted logrank statistic under the null hypothesis is obtained. We show that, in an observational study where the treatment selection probabilities need to be estimated, the estimation of these probabilities does not have an effect on the asymptotic distribution of the weighted logrank statistic, as long as the estimation of the parameters in the models for these probabilities is n-consistent. Finite sample performance of the test is assessed via a simulation study. We also show in the simulation that the test can be pretty robust to misspecification of the models for the probabilities of treatment selection. The method is applied to analyze data on antidepressant adherence time from an observational database maintained at the Department of Veterans Affairs' Serious Mental Illness Treatment Research and Evaluation Center.

  9. Postural strategies employed by orangutans (Pongo abelii) during feeding in the terminal branch niche.

    PubMed

    Myatt, J P; Thorpe, S K S

    2011-09-01

    Obtaining food in an arboreal habitat is complex due to the irregular and flexible nature of the supports available. As the largest predominantly arboreal primate, orangutans are expected to have developed particular postural strategies to enable them to feed successfully. In particular, they need to be able to cope within the terminal branch niche (TBN) as this is where the smallest, most compliant supports are, and also where the majority of the fruit and leaves are situated. We recorded feeding posture, along with a number of ecological and behavioral variables from different age-sex classes to enable analysis of the interactions between these and the compliance of the supports (as estimated from stiffness score). Suspensory postures with a pronograde orientation were used on the most compliant supports for all age-sex classes and appeared to play a particular role in facilitating safe use of the TBN by distributing body weight and using limbs for balance across multiple supports. This contradicts the idea that orthograde suspension evolved in response to the demands of feeding in the TBN. Adult males appear to use the same postures and feeding zones as the other age-sex classes, but appear to use stiffer supports where possible due to their larger body mass. Feeding method differed between the age-sex classes in relation to support stiffness, with larger adult males taking fewer risks due to their larger size, compared to infants and juveniles.

  10. Strategies employed by sexual minority adolescents to cope with minority stress

    PubMed Central

    Goldbach, J.T.; Gibbs, J.J.

    2015-01-01

    Sexual minority adolescents (SMA) experience disparities in health and behavioral health outcomes, including high rates of depression, anxiety, self-harm, substance use, HIV risk behavior, suicidal ideation, and suicide attempts. These outcomes are commonly attributed to minority stress. Stress experiences are different for SMA than their adult counterparts. For example, disclosing their sexual orientation may be more likely to result in homelessness because these youth more often live with parents or other family members. Although stress in this population has been explored in previous research, very little is known about how SMA cope. Relying upon an adolescent coping model, this study examined the coping strategies, responses, and resources of SMA related to stress. Forty-eight racially and ethnically diverse SMA (age 14–19) were recruited for 90-minute tape-recorded interviews. The semi-structured interviews were guided by a life history calendar. Recordings were transcribed verbatim and entered into QSR NVivo. All transcripts were coded by two members of the research team and went through a consensus process. Forty-three unique coping statements emerged that fit with the Compas model of adolescent coping. SMA cope with minority stress in similar ways to heterosexual youth coping with general stress, but findings suggest that SMA may also use different kinds of coping resources. Although further research is needed, the present study identified a variety of ways SMA cope with stress and can inform future research on the development interventions. PMID:26634221

  11. Strategies employed by sexual minority adolescents to cope with minority stress.

    PubMed

    Goldbach, J T; Gibbs, J J

    2015-09-01

    Sexual minority adolescents (SMA) experience disparities in health and behavioral health outcomes, including high rates of depression, anxiety, self-harm, substance use, HIV risk behavior, suicidal ideation, and suicide attempts. These outcomes are commonly attributed to minority stress. Stress experiences are different for SMA than their adult counterparts. For example, disclosing their sexual orientation may be more likely to result in homelessness because these youth more often live with parents or other family members. Although stress in this population has been explored in previous research, very little is known about how SMA cope. Relying upon an adolescent coping model, this study examined the coping strategies, responses, and resources of SMA related to stress. Forty-eight racially and ethnically diverse SMA (age 14-19) were recruited for 90-minute tape-recorded interviews. The semi-structured interviews were guided by a life history calendar. Recordings were transcribed verbatim and entered into QSR NVivo. All transcripts were coded by two members of the research team and went through a consensus process. Forty-three unique coping statements emerged that fit with the Compas model of adolescent coping. SMA cope with minority stress in similar ways to heterosexual youth coping with general stress, but findings suggest that SMA may also use different kinds of coping resources. Although further research is needed, the present study identified a variety of ways SMA cope with stress and can inform future research on the development interventions.

  12. Curbing the tobacco epidemic: Employing behavioral strategies or rearranging the deckchairs on the Titanic?

    PubMed

    Braillon, Alain

    2015-04-01

    Henningfield brilliantly dissected the deadly comprehensive tactics of the tobacco industry but Food and Drug Administration and WHO strategies against the tobacco epidemic must be questioned. The Food and Drug Administration has the authority to regulate tobacco production (2009 Tobacco Control Act) but fails to ban menthol and reduce cigarettes nicotine content. As little has changed, the Healthy People 2010 objective of reducing the prevalence of cigarette smoking among adults to 12% by 2010 in the US will be attained by 2030. The monitoring of the WHO Framework Convention on Tobacco Control (WHO FCTC) is passive, even when governments repeatedly violate the Article 5.3 of the Convention, which specifically requires protecting public policy from tobacco industry interference. Since 2004, the year after the adoption of the Convention, the prevalence of daily smoking has leveled off and the 2012 annualized rate of change in prevalence of daily smoking was almost null. This contrasts with a 2% annual decrease in the prevalence of daily smoking from 1980 to 2004. The tobacco endgame needs acts, not bureaucracies. Two counties have been moving forward, Brazil has banned menthol and Australia has implemented plain packaging.

  13. Livestock in a changing climate: production system transitions as an adaptation strategy for agriculture

    NASA Astrophysics Data System (ADS)

    Weindl, Isabelle; Lotze-Campen, Hermann; Popp, Alexander; Müller, Christoph; Havlík, Petr; Herrero, Mario; Schmitz, Christoph; Rolinski, Susanne

    2015-09-01

    Livestock farming is the world’s largest land use sector and utilizes around 60% of the global biomass harvest. Over the coming decades, climate change will affect the natural resource base of livestock production, especially the productivity of rangeland and feed crops. Based on a comprehensive impact modeling chain, we assess implications of different climate projections for agricultural production costs and land use change and explore the effectiveness of livestock system transitions as an adaptation strategy. Simulated climate impacts on crop yields and rangeland productivity generate adaptation costs amounting to 3% of total agricultural production costs in 2045 (i.e. 145 billion US). Shifts in livestock production towards mixed crop-livestock systems represent a resource- and cost-efficient adaptation option, reducing agricultural adaptation costs to 0.3% of total production costs and simultaneously abating deforestation by about 76 million ha globally. The relatively positive climate impacts on grass yields compared with crop yields favor grazing systems inter alia in South Asia and North America. Incomplete transitions in production systems already have a strong adaptive and cost reducing effect: a 50% shift to mixed systems lowers agricultural adaptation costs to 0.8%. General responses of production costs to system transitions are robust across different global climate and crop models as well as regarding assumptions on CO2 fertilization, but simulated values show a large variation. In the face of these uncertainties, public policy support for transforming livestock production systems provides an important lever to improve agricultural resource management and lower adaptation costs, possibly even contributing to emission reduction.

  14. Biomimetic Strategies Employed in the Formation of Biotargeted Metal Nanoparticles for Optical Imaging and Photothermal Therapy

    NASA Astrophysics Data System (ADS)

    Black, Kvar Carl Lee, IV

    Diseases resistant to current treatment protocols like chemo resistant cancers and antibiotic resistant bacterial infections require treatments with novel mechanisms of action. Metal nanoparticles (NPs) have unique dielectric properties that give rise to the surface plasmon resonance (SPR), which causes these materials to interact strongly with light. With multifunctional surface modifications, metal NPs have the potential to diagnose and treat diseases like cancer and bacterial infections with optical imaging techniques and light-activated photothermal therapy. With the ability to interact strongly with metals and organics, versatile catecholamine molecules inspired by marine mussels can be used to synthesize metal NPs and functionalize them with a variety of molecules. With this biomimetic tool, these metal NPs can be formed and stabilized in physiological environments and functionalized to specifically target diseased cell surfaces. Herein, molecules containing catechols and amines are used to form gold and silver NPs and tune their SPR optical properties throughout the visible and near-infrared (NIR) region of the electromagnetic spectrum with shape and compositional control. A variety of chemical mechanisms including catechol redox activity are employed in the metal NP formation and functionalization to engineer robust metal-organic interfaces for biomedical applications. Antibodies are functionalized onto metal NPs to provide specific targeting to cancer and bacterial cell surfaces. For cancer, the epidermal growth factor receptor, overexpressed in a variety of cancers, is targeted in oral and breast cancer cells. For bacteria, NPs are targeted to endotoxins on gram-negative escherichia coli membranes and lipoteichoic acids in gram-positive staphylococcus epidermidis cell walls. Optical techniques including optical coherence tomography (OCT) and bright field microscopy are used to identify NPs on cells, and photothermal therapy is successfully demonstrated

  15. Enhancement of Chemokine Function as an Immunomodulatory Strategy Employed by Human Herpesviruses

    PubMed Central

    Viejo-Borbolla, Abel; Martinez-Martín, Nadia; Nel, Hendrik J.; Rueda, Patricia; Martín, Rocío; Blanco, Soledad; Arenzana-Seisdedos, Fernando; Thelen, Marcus; Fallon, Padraic G.; Alcamí, Antonio

    2012-01-01

    Herpes simplex virus (HSV) types 1 and 2 are highly prevalent human neurotropic pathogens that cause a variety of diseases, including lethal encephalitis. The relationship between HSV and the host immune system is one of the main determinants of the infection outcome. Chemokines play relevant roles in antiviral response and immunopathology, but the modulation of chemokine function by HSV is not well understood. We have addressed the modulation of chemokine function mediated by HSV. By using surface plasmon resonance and crosslinking assays we show that secreted glycoprotein G (SgG) from both HSV-1 and HSV-2 binds chemokines with high affinity. Chemokine binding activity was also observed in the supernatant of HSV-2 infected cells and in the plasma membrane of cells infected with HSV-1 wild type but not with a gG deficient HSV-1 mutant. Cell-binding and competition experiments indicate that the interaction takes place through the glycosaminoglycan-binding domain of the chemokine. The functional relevance of the interaction was determined both in vitro, by performing transwell assays, time-lapse microscopy, and signal transduction experiments; and in vivo, using the air pouch model of inflammation. Interestingly, and in contrast to what has been observed for previously described viral chemokine binding proteins, HSV SgGs do not inhibit chemokine function. On the contrary, HSV SgGs enhance chemotaxis both in vitro and in vivo through increasing directionality, potency and receptor signaling. This is the first report, to our knowledge, of a viral chemokine binding protein from a human pathogen that increases chemokine function and points towards a previously undescribed strategy of immune modulation mediated by viruses. PMID:22319442

  16. Persistence versus Escape: Aspergillus terreus and Aspergillus fumigatus Employ Different Strategies during Interactions with Macrophages

    PubMed Central

    Slesiona, Silvia; Gressler, Markus; Mihlan, Michael; Zaehle, Christoph; Schaller, Martin; Barz, Dagmar; Hube, Bernhard; Jacobsen, Ilse D.; Brock, Matthias

    2012-01-01

    Invasive bronchopulmonary aspergillosis (IBPA) is a life-threatening disease in immunocompromised patients. Although Aspergillus terreus is frequently found in the environment, A. fumigatus is by far the main cause of IBPA. However, once A. terreus establishes infection in the host, disease is as fatal as A. fumigatus infections. Thus, we hypothesized that the initial steps of disease establishment might be fundamentally different between these two species. Since alveolar macrophages represent one of the first phagocytes facing inhaled conidia, we compared the interaction of A. terreus and A. fumigatus conidia with alveolar macrophages. A. terreus conidia were phagocytosed more rapidly than A. fumigatus conidia, possibly due to higher exposure of β-1,3-glucan and galactomannan on the surface. In agreement, blocking of dectin-1 and mannose receptors significantly reduced phagocytosis of A. terreus, but had only a moderate effect on phagocytosis of A. fumigatus. Once phagocytosed, and in contrast to A. fumigatus, A. terreus did not inhibit acidification of phagolysosomes, but remained viable without signs of germination both in vitro and in immunocompetent mice. The inability of A. terreus to germinate and pierce macrophages resulted in significantly lower cytotoxicity compared to A. fumigatus. Blocking phagolysosome acidification by the v-ATPase inhibitor bafilomycin increased A. terreus germination rates and cytotoxicity. Recombinant expression of the A. nidulans wA naphthopyrone synthase, a homologue of A. fumigatus PksP, inhibited phagolysosome acidification and resulted in increased germination, macrophage damage and virulence in corticosteroid-treated mice. In summary, we show that A. terreus and A. fumigatus have evolved significantly different strategies to survive the attack of host immune cells. While A. fumigatus prevents phagocytosis and phagolysosome acidification and escapes from macrophages by germination, A. terreus is rapidly phagocytosed, but

  17. Mixed-gender groups: coping strategies and factors of psychological adaptation in a polar environment.

    PubMed

    Rosnet, Elisabeth; Jurion, Sylvie; Cazes, Geneviève; Bachelard, Claude

    2004-07-01

    The polar environment is often seen as a good analog for long-term space missions in terms of isolation and confinement. This paper focuses on the psychological adaptation of both the men and women in mixed-gender groups in the French polar station Dumont d'Urville. The first 49 expeditions to this station were composed of men only in groups of 25-30. In 2000, two women were included in the first mixed-gender wintering group, followed by five women in 2001. This study on coping strategies and psychological adaptation was included in an end-of-mission debriefing performed by a psychologist. Data were collected using a few quantitative tools and a semi-structured interview, and focused on adaptation to wintering, coping strategies, and information on interpersonal relationships. Including women in a wintering group seems to have had positive effects on the general climate of the group by reducing men's rude behavior, but it also seems to be an important stressor for both men and women when the females' average age is close to the males' because seduction behaviors appear and rivalry, frustration, and sexual harassment frequently result. The use of problem-oriented strategies helps women to adapt. There are strong arguments indicating that living in an isolated and confined environment magnifies the usual difficulties that arise in mixed-gender relationships. Difficulties may be magnified in space since the group size is smaller and the confinement more extreme. This implies the need for rigorous select-in criteria for both men and women, especially for relational criteria, and for group training after selection.

  18. Employability Skills: Final Report--Development of a Strategy to Support the Universal Recognition and Recording of Employability Skills. A Skills Portfolio Approach

    ERIC Educational Resources Information Center

    Australian Government Department of Education, Science and Training, 2004

    2004-01-01

    Employability skills recognition and recording models that are practical, cross-sectoral and consistent with life-long learning have the potential to be useful to many within the community. Students will benefit as they transition through and from school to work or further education and training. People in employment will benefit as they…

  19. Simulation of control strategies for the cattle tick Boophilus microplus employing vaccination with a recombinant Bm86 antigen preparation.

    PubMed

    Labarta, V; Rodríguez, M; Penichet, M; Lleonart, R; Luaces, L L; de la Fuente, J

    1996-05-01

    Current strategies for the control of the cattle tick Boophilus microplus include the use of chemicals as the principal control method. These methods, however, have met with partially successful results. The recent development of immunological methods for the control of the cattle tick has opened new possibilities for the design of control strategies. Employing the results obtained by us in experiments testing the effect of vaccination with the recombinant vaccine, Gavac (Heber Biotec S.A.), on tick populations, we have developed a model to evaluate, through a computer program, the efficacy of the vaccine as a control method. The action of the vaccine on the control of tick populations was simulated and the specific serum antibody titers required to decrease the tick population in the field were calculated. The specific serum antibody titer required to decrease the tick population in the field after the first vaccination scheme was found to be > or = 57,200 and the antibody titer required to maintain this effect when the vaccine is already acting and after successive revaccinations was found to be > or = 27,500. Considerations about revaccination schemes and combination between vaccination and acaricide treatments as possible control strategies are discussed.

  20. Why did the meerkat cross the road? Flexible adaptation of phylogenetically-old behavioural strategies to modern-day threats.

    PubMed

    Perony, Nicolas; Townsend, Simon W

    2013-01-01

    Risk-sensitive adaptive spatial organisation during group movement has been shown to efficiently minimise the risks associated with external ecological threats. Whether animals can draw on such behaviours when confronted with man-made threats is generally less clear. We studied road-crossing in a wild, but habituated, population of meerkats living in the Kalahari Desert, South Africa. We found that dominant females, the core member in meerkat social systems, led groups to the road significantly more often than subordinates, yet were consistently less likely to cross first. Our results suggest that a reshuffling occurs in progression order when meerkat groups reach the road. By employing a simple model of collective movement, we have shown that risk aversion alone may be sufficient to explain this reshuffling, but that the risk aversion of dominant females toward road crossing is significantly higher than that of subordinates. It seems that by not crossing first, dominant females avoid occupying the most risky, exposed locations, such as at the front of the group--a potential selfish strategy that also promotes the long-term stability and hence reproductive output of their family groups. We argue that our findings support the idea that animals can flexibly apply phylogenetically-old behavioural strategies to deal with emerging modern-day problems.

  1. Why Did the Meerkat Cross the Road? Flexible Adaptation of Phylogenetically-Old Behavioural Strategies to Modern-Day Threats

    PubMed Central

    Perony, Nicolas; Townsend, Simon W.

    2013-01-01

    Risk-sensitive adaptive spatial organisation during group movement has been shown to efficiently minimise the risks associated with external ecological threats. Whether animals can draw on such behaviours when confronted with man-made threats is generally less clear. We studied road-crossing in a wild, but habituated, population of meerkats living in the Kalahari Desert, South Africa. We found that dominant females, the core member in meerkat social systems, led groups to the road significantly more often than subordinates, yet were consistently less likely to cross first. Our results suggest that a reshuffling occurs in progression order when meerkat groups reach the road. By employing a simple model of collective movement, we have shown that risk aversion alone may be sufficient to explain this reshuffling, but that the risk aversion of dominant females toward road crossing is significantly higher than that of subordinates. It seems that by not crossing first, dominant females avoid occupying the most risky, exposed locations, such as at the front of the group – a potential selfish strategy that also promotes the long-term stability and hence reproductive output of their family groups. We argue that our findings support the idea that animals can flexibly apply phylogenetically-old behavioural strategies to deal with emerging modern-day problems. PMID:23441144

  2. Adaptation of Decoy Fusion Strategy for Existing Multi-Stage Search Workflows

    NASA Astrophysics Data System (ADS)

    Ivanov, Mark V.; Levitsky, Lev I.; Gorshkov, Mikhail V.

    2016-09-01

    A number of proteomic database search engines implement multi-stage strategies aiming at increasing the sensitivity of proteome analysis. These approaches often employ a subset of the original database for the secondary stage of analysis. However, if target-decoy approach (TDA) is used for false discovery rate (FDR) estimation, the multi-stage strategies may violate the underlying assumption of TDA that false matches are distributed uniformly across the target and decoy databases. This violation occurs if the numbers of target and decoy proteins selected for the second search are not equal. Here, we propose a method of decoy database generation based on the previously reported decoy fusion strategy. This method allows unbiased TDA-based FDR estimation in multi-stage searches and can be easily integrated into existing workflows utilizing popular search engines and post-search algorithms.

  3. Reducing the time complexity of the derandomized evolution strategy with covariance matrix adaptation (CMA-ES).

    PubMed

    Hansen, Nikolaus; Müller, Sibylle D; Koumoutsakos, Petros

    2003-01-01

    This paper presents a novel evolutionary optimization strategy based on the derandomized evolution strategy with covariance matrix adaptation (CMA-ES). This new approach is intended to reduce the number of generations required for convergence to the optimum. Reducing the number of generations, i.e., the time complexity of the algorithm, is important if a large population size is desired: (1) to reduce the effect of noise; (2) to improve global search properties; and (3) to implement the algorithm on (highly) parallel machines. Our method results in a highly parallel algorithm which scales favorably with large numbers of processors. This is accomplished by efficiently incorporating the available information from a large population, thus significantly reducing the number of generations needed to adapt the covariance matrix. The original version of the CMA-ES was designed to reliably adapt the covariance matrix in small populations but it cannot exploit large populations efficiently. Our modifications scale up the efficiency to population sizes of up to 10n, where n is the problem dimension. This method has been applied to a large number of test problems, demonstrating that in many cases the CMA-ES can be advanced from quadratic to linear time complexity.

  4. Adaptive Optics Facility: control strategy and first on-sky results of the acquisition sequence

    NASA Astrophysics Data System (ADS)

    Madec, P.-Y.; Kolb, J.; Oberti, S.; Paufique, J.; La Penna, P.; Hackenberg, W.; Kuntschner, H.; Argomedo, J.; Kiekebusch, M.; Donaldson, R.; Suarez, M.; Arsenault, R.

    2016-07-01

    The Adaptive Optics Facility is an ESO project aiming at converting Yepun, one of the four 8m telescopes in Paranal, into an adaptive telescope. This is done by replacing the current conventional secondary mirror of Yepun by a Deformable Secondary Mirror (DSM) and attaching four Laser Guide Star (LGS) Units to its centerpiece. In the meantime, two Adaptive Optics (AO) modules have been developed incorporating each four LGS WaveFront Sensors (WFS) and one tip-tilt sensor used to control the DSM at 1 kHz frame rate. The four LGS Units and one AO module (GRAAL) have already been assembled on Yepun. Besides the technological challenge itself, one critical area of AOF is the AO control strategy and its link with the telescope control, including Active Optics used to shape M1. Another challenge is the request to minimize the overhead due to AOF during the acquisition phase of the observation. This paper presents the control strategy of the AOF. The current control of the telescope is first recalled, and then the way the AO control makes the link with the Active Optics is detailed. Lab results are used to illustrate the expected performance. Finally, the overall AOF acquisition sequence is presented as well as first results obtained on sky with GRAAL.

  5. Assessing effects of climate change and adaptation strategies on irrigated pastures using DAISY

    NASA Astrophysics Data System (ADS)

    Hagimoto, Y.; Cuenca, R. H.

    2013-12-01

    The DAISY ecological model was applied for the flood-irrigated cool-season pastures in the Upper Klamath Basin, Oregon to study 1) the current condition of the pastures in the semi-arid environment, 2) effects of projected climate change, and 3) effects of introducing white clover and a sprinkler system as a potential adaptation strategy. The calibrated model indicated that productivity of the cool-season pastures was limited primarily by nitrogen (N) availability and temperature. The results of our scenario analysis indicated that the projected climate change would increase seasonal forage production (YF) and crop water use (AET) due to longer and warmer growing season. This study also found that introduction of white clover would significantly increase YF without changing AET by improving N availability due to increased nutrients deposition by cattle and increased symbiotic N fixation by white clover. In consequence, the mixed pasture could significantly improve water use efficiency (YF/AET) and, therefore the adaptability of the pasture in an area with high value water. Installing sprinkler system to the mixed pasture would increase YF by increasing net N input by increasing N mineralization and reducing denitrification. Furthermore, upgraded irrigation systems could increase water availability of the area during growing season by releasing significant amount of subsurface water to nearby surface water pools. This study demonstrated that ecological models such as DAISY can be a useful tool to model pasture systems and assess effects of projected climate changes and adaptation strategies.

  6. Modeling of the Urban Heat Island (UHI) using WRF - Assessment of adaptation and mitigation strategies for the city of Stuttgart.

    NASA Astrophysics Data System (ADS)

    Fallmann, Joachim; Suppan, Peter; Emeis, Stefan

    2013-04-01

    Cities are warmer than their surroundings (called urban heat island, UHI). UHI influence urban atmospheric circulation, air quality, and ecological conditions. UHI leads to upward motion and compensating near-surface inflow from the surroundings which import rural trace substances. Chemical and aerosol formation processes are modified due to increased temperature, reduced humidity and modified urban-rural trace substance mixtures. UHIs produce enhanced heat stress for humans, animals and plants, less water availability and modified air quality. Growing cities and Climate Change will aggravate the UHI and its effects and urgently require adaptation and mitigation strategies. Prior to this, UHI properties must be assessed by surface observations, ground- and satellite-based vertical remote sensing and numerical modelling. The Weather Research and Forecasting Model (WRF) is an instrument to simulate and assess this phenomenon based on boundary conditions from observations and global climate models. Three urbanization schemes are available with WRF, which are tested during this study for different weather conditions in central Europe and will be enhanced if necessary. High resolution land use maps are used for this modeling effort. In situ measurements and Landsat thermal images are employed for validation of the results. The study will focus on the city of Stuttgart located in the south western part of Germany that is situated in a caldera-like orographic feature. This municipality has a long tradition in urban climate research and thus is well equipped with climatologic measurement stations. By using Geographical Information Systems (GIS), it is possible to simulate several scenarios for different surface properties. By increasing the albedo of roof and wall layers in the urban canopy model or by replacing urban land use by natural vegetation, simple urban planning strategies can be tested and the effect on urban heat island formation and air quality can be

  7. Compromise-based Robust Prioritization of Climate Change Adaptation Strategies for Watershed Management

    NASA Astrophysics Data System (ADS)

    Kim, Y.; Chung, E. S.

    2014-12-01

    This study suggests a robust prioritization framework for climate change adaptation strategies under multiple climate change scenarios with a case study of selecting sites for reusing treated wastewater (TWW) in a Korean urban watershed. The framework utilizes various multi-criteria decision making techniques, including the VIKOR method and the Shannon entropy-based weights. In this case study, the sustainability of TWW use is quantified with indicator-based approaches with the DPSIR framework, which considers both hydro-environmental and socio-economic aspects of the watershed management. Under the various climate change scenarios, the hydro-environmental responses to reusing TWW in potential alternative sub-watersheds are determined using the Hydrologic Simulation Program in Fortran (HSPF). The socio-economic indicators are obtained from the statistical databases. Sustainability scores for multiple scenarios are estimated individually and then integrated with the proposed approach. At last, the suggested framework allows us to prioritize adaptation strategies in a robust manner with varying levels of compromise between utility-based and regret-based strategies.

  8. Driving Difficulties and Adaptive Strategies: The Perception of Individuals Having Sustained a Mild Traumatic Brain Injury

    PubMed Central

    Bottari, Carolina; Lamothe, Marie-Pierre; Gosselin, Nadia; Gélinas, Isabelle; Ptito, Alain

    2012-01-01

    Introduction. After a mild traumatic brain injury (mTBI), individuals quickly resume driving. However, relatively little is known about the impact of mTBI on driving ability and, notably, on the perceived influence of postconcussive symptoms on driving. Hence, the objective of this study was to document the perception of driving abilities in individuals with mTBI. Method. Twenty-seven drivers with mTBI were interviewed to document their perception regarding their driving abilities. Both driving-related difficulties and compensatory strategies used to increase driving safety were documented. A mixed quantitative and qualitative analysis of the data was completed. Results. 93% of participants reported at least one difficulty perceived as having an impact on everyday activities. Most frequently named problems affecting driving were fatigue and reduced concentration. In addition, 74% of participants had adapted their driving or developed strategies to compensate for driving difficulties. Discussion/Conclusion. Postconcussive symptoms have repercussions on driving ability. However, people with mTBI tend to be aware of their difficulties and develop, over time, adaptive strategies. Preventive measures are thus warranted to increase health care professionals' awareness of the potential consequences of mTBI on driving ability and to promote guidelines for the safe resumption of driving after injury. PMID:22448334

  9. The communication of physical science uncertainty in European National Adaptation Strategies.

    PubMed

    Lorenz, S; Dessai, S; Paavola, J; Forster, P M

    Many European countries have developed National Adaptation Strategies (NAS) to guide adaptation to the expected impacts of climate change. There is a need for more structured communication of the uncertainties related to future climate and its impacts so that adaptation actions can be planned and implemented effectively and efficiently. We develop a novel uncertainty assessment framework for comparing approaches to the inclusion and communication of physical science uncertainty, and use it to analyse ten European NAS. The framework is based on but modifies and integrates the notion of the "cascade of uncertainties" and the NUSAP (Numeral Unit Spread Assessment Pedigree) methodology to include the overarching assessment categories of Numerical Value, Spread, Depth and Substantiation. Our assessment indicates that there are marked differences between the NAS in terms of inclusion and communication of physical science uncertainty. We find that there is a bias towards the communication of quantitative uncertainties as opposed to qualitative uncertainties. Through the examination of the English and German NAS, we find that similar stages of development in adaptation policy planning can nevertheless result in differences in handling physical science uncertainty. We propose that the degree of transparency and openness on physical science uncertainty is linked to the wider socio-political context within which the NAS are framed. Our methodology can help raise awareness among NAS users about the explicit and embedded information on physical science uncertainty within the existing NAS and would help to design more structured uncertainty communication in new or revised NAS.

  10. Adaptive strategies in the double-extremophilic prokaryotes inhabiting soda lakes.

    PubMed

    Banciu, Horia Leonard; Muntyan, Maria S

    2015-06-01

    Haloalkaliphiles are double extremophilic organisms thriving both at high salinity and alkaline pH. Although numerous haloalkaliphilic representatives have been identified among Archaea and Bacteria over the past 15 years, the adaptations underlying their prosperity at haloalkaline conditions are scarcely known. A multi-level adaptive strategy was proposed to occur in haloalkaliphilic organisms isolated from saline alkaline and soda environments including adjustments in the cell wall structure, plasma membrane lipid composition, membrane transport systems, bioenergetics, and osmoregulation. Isolation of chemolithoautotrophic sulfur-oxidizing γ-Proteobacteria from soda lakes allowed the elucidation of the structural and physiological differences between haloalkaliphilic (prefer NaCl) and natronophilic (prefer NaHCO3/Na2CO3, i.e. soda) microbes.

  11. Water law as an adaptation strategy for global water scarcity in the future

    NASA Astrophysics Data System (ADS)

    Kakinuma, K.; Yoshikawa, S.; Endo, T.; Kanae, S.

    2014-12-01

    Water scarcity due to climate changes and growing human population is a major concern for the world. Adaptation and mitigation strategies should be developed for water scarcity in the future. Previous studies assessed the future water availability by hard technology (e.g., reservoirs, reclaimed and desalinated water plants) as adaptation strategies. On the other hand, soft path such as water law and policy would also be important for adaptation strategies. Water transfers is reallocation of water among water users. For example, distribution of the amount of available water is often heterogeneous especially during drought periods. If water transfers are permitted in these areas, water can be moved from surplus areas/sections to critical need areas/sections. There are several studies which describe the water transfer at the local scales (i.e., water bank in California), however the factors that determined the establishment of water transfer are not clear. If we can detect the factors, it could be used to estimate in which areas the water transfer would come into existence. This in turn would reduce the water stress. Here, we focus on historical interaction between human activity and water environments. Generally, rules of water use are developed by repeated discussion among water users. The frequency of these discussions would be related with their land use, frequency of drought and water resource sizes. For example, people in rice crop area need to discuss about water allocation compared to wheat crop area. Therefore, we examine the relationship between the permission of water transfer and factors such as water environment and human activity in the world.

  12. Design of acoustic metamaterials using the covariance matrix adaptation evolutionary strategy

    NASA Astrophysics Data System (ADS)

    Huang, Bei; Cheng, Qiang; Song, Gang Yong; Cui, Tie Jun

    2017-03-01

    Acoustic metamaterials can manipulate sound waves in surprising ways, including the focusing, cloaking, and extraordinary transmitting of sound waves. With the increasing requirements for acoustic metamaterials with extreme parameters, we propose the design of acoustic meta-atoms with a large refraction index using the covariance matrix adaptation evolutionary optimization strategy. To validate the procedure, we propose an optimized metamaterial to construct an acoustic deflection lens. The full-wave simulation results are consistent with the theoretical predictions, showing the efficacy and accuracy of the proposed method, and indicating that the optimization algorithm is a powerful tool for designing meta-atoms with excellent applications.

  13. A study to evaluate STS heads-up ascent trajectory performance employing a minimum-Hamiltonian optimization strategy

    NASA Technical Reports Server (NTRS)

    Sinha, Sujit

    1988-01-01

    A study was conducted to evaluate the performance implications of a heads-up ascent flight design for the Space Transportation System, as compared to the current heads-down flight mode. The procedure involved the use of the Minimum Hamiltonian Ascent Shuttle Trajectory Evaluation Program, which is a three-degree-of-freedom moment balance simulation of shuttle ascent. A minimum-Hamiltonian optimization strategy was employed to maximize injection weight as a function of maximum dynamic pressure constraint and Solid Rocket Motor burnrate. Performance Reference Mission Four trajectory groundrules were used for consistency. The major conclusions are that for heads-up ascent and a mission nominal design maximum dynamic pressure value of 680 psf, the optimum solid motor burnrate is 0.394 ips, which produces a performance enhancement of 4293 lbm relative to the baseline heads-down ascent, with 0.368 ips burnrate solid motors and a 680 psf dynamic pressure constraint. However, no performance advantage exists for heads-up flight if the current Solid Rocket Motor target burnrate of 0.368 ips is used. The advantage of heads-up ascent flight employing the current burnrate is that Space Shuttle Main Engine throttling for dynamic pressure control is not necessary.

  14. An innovative cross-sectoral method for implementation of trade-off adaptation strategy assessment under climate change

    NASA Astrophysics Data System (ADS)

    Tsao, Jung-Hsuan; Tung, Ching-Pin; Liu, Tzu-Ming

    2014-05-01

    Climate change will increase sharp risks to the water and food supply in coming decades. Although impact assessment and adaptation evaluation has been discussed a lot in recent years, the importance of adaptation implement should not be ignored. In Taiwan, and elsewhere, fallow is an option of adaptation strategy under climate change. Fallow would improve the water scarcity of domestic use, but the food security might be threatened. The trade-off effects of adaptation actions are just like the side effects of medicine which cannot be avoided. Thus, managing water resources with an integrated approach will be urgent. This study aims to establish a cross-sectoral framework for implementation the trade-off adaptation strategy. Not only fallow, but also other trade-off strategy like increasing the percentage of national grain self-sufficiency would be analyzed by a rational decision process. The recent percentage of grain self-sufficiency in Taiwan is around 32, which was decreasing from 53 thirty years ago. Yet, the goal of increasing grain self-sufficiency means much more water must be used in agriculture. In that way, domestic users may face the water shortage situation. Considering the conflicts between water supply and food security, the concepts from integrative negotiation are appropriate to apply. The implementation of trade-off adaptation strategies needs to start by quantifying the utility of water supply and food security were be quantified. Next, each side's bottom line can be found by BATNA (Best Alternative to a Negotiated Agreement) and ZOPA (Zone of Possible Agreement). ZOPA provides the entire possible outcomes, and BATNA ensures the efficiency of adaptation actions by moving along with Pareto frontier. Therefore, the optimal percentage of fallow and grain self-sufficiency can be determined. Furthermore, BATNA also provides the pathway step by step which can be a guideline of adaptation strategies. This framework allows analysts and stakeholder to

  15. Saprolegnia diclina IIIA and S. parasitica employ different infection strategies when colonizing eggs of Atlantic salmon, Salmo salar L.

    PubMed

    Songe, M M; Willems, A; Wiik-Nielsen, J; Thoen, E; Evensen, Ø; van West, P; Skaar, I

    2016-03-01

    Here, we address the morphological changes of eyed eggs of Atlantic salmon, Salmo salar L. infected with Saprolegnia from a commercial hatchery and after experimental infection. Eyed eggs infected with Saprolegnia spp. from 10 Atlantic salmon females were obtained. Egg pathology was investigated by light and scanning electron microscopy. Eggs from six of ten females were infected with S. parasitica, and two females had infections with S. diclina clade IIIA; two Saprolegnia isolates remained unidentified. Light microscopy showed S. diclina infection resulted in the chorion in some areas being completely destroyed, whereas eggs infected with S. parasitica had an apparently intact chorion with hyphae growing within or beneath the chorion. The same contrasting pathology was found in experimentally infected eggs. Scanning electron microscopy revealed that S. parasitica grew on the egg surface and hyphae were found penetrating the chorion of the egg, and re-emerging on the surface away from the infection site. The two Saprolegnia species employ different infection strategies when colonizing salmon eggs. Saprolegnia diclina infection results in chorion destruction, while S. parasitica penetrates intact chorion. We discuss the possibility these infection mechanisms representing a necrotrophic (S. diclina) vs. a facultative biotrophic strategy (S. parasitica).

  16. Effectiveness and Tradeoffs between Portfolios of Adaptation Strategies Addressing Future Climate and Socioeconomic Uncertainties in California's Central Valley

    NASA Astrophysics Data System (ADS)

    Tansey, M. K.; Van Lienden, B.; Das, T.; Munevar, A.; Young, C. A.; Flores-Lopez, F.; Huntington, J. L.

    2013-12-01

    The Central Valley of California is one of the major agricultural areas in the United States. The Central Valley Project (CVP) is operated by the Bureau of Reclamation to serve multiple purposes including generating approximately 4.3 million gigawatt hours of hydropower and providing, on average, 5 million acre-feet of water per year to irrigate approximately 3 million acres of land in the Sacramento, San Joaquin, and Tulare Lake basins, 600,000 acre-feet per year of water for urban users, and 800,000 acre-feet of annual supplies for environmental purposes. The development of effective adaptation and mitigation strategies requires assessing multiple risks including potential climate changes as well as uncertainties in future socioeconomic conditions. In this study, a scenario-based analytical approach was employed by combining three potential 21st century socioeconomic futures with six representative climate and sea level change projections developed using a transient hybrid delta ensemble method from an archive of 112 bias corrected spatially downscaled CMIP3 global climate model simulations to form 18 future socioeconomic-climate scenarios. To better simulate the effects of climate changes on agricultural water demands, analyses of historical agricultural meteorological station records were employed to develop estimates of future changes in solar radiation and atmospheric humidity from the GCM simulated temperature and precipitation. Projected changes in atmospheric carbon dioxide were computed directly by weighting SRES emissions scenarios included in each representative climate projection. These results were used as inputs to a calibrated crop water use, growth and yield model to simulate the effects of climate changes on the evapotranspiration and yields of major crops grown in the Central Valley. Existing hydrologic, reservoir operations, water quality, hydropower, greenhouse gas (GHG) emissions and both urban and agricultural economic models were integrated

  17. Flash Flood Risk Perception in an Italian Alpine Region. From Research into Adaptive Strategies.

    NASA Astrophysics Data System (ADS)

    Scolobig, A.; de Marchi, B.; Borga, M.

    2009-04-01

    Flash floods are characterised by short lead times and high levels of uncertainty. Adaptive strategies to face them need to take into account not only the physical characteristics of the hydro-geological phenomena, but also peoples' risk perceptions, attitudes and behaviours in case of an emergency. It is quite obvious that a precondition for an effective adaptation, e.g. in the case of a warning, is the awareness of being endangered. At the same time the perceptions of those at risk and their likely actions inform hazard warning strategies and recovery programmes following such events. Usually low risk awareness or "wrong perceptions" of the residents are considered among the causes of an inadequate preparedness or response to flash floods as well as a symptom of a scarce self-protection culture. In this paper we will focus on flood risk perception and on how research on this topic may contribute to design adaptive strategies and give inputs to flood policy decisions. We will report on a flood risk perception study of the population residing in four villages in an Italian Alpine Region (Trentino Alto-Adige), carried out between October 2005 and January 2006. A total of 400 standardised questionnaires were submitted to local residents by face to face interviews. The surveys were preceded by focus groups with officers from agencies in charge of flood risk management and semi-structured and in-depth interviews with policy, scientific and technical experts. Survey results indicated that people are not so worried about hydro-geological phenomena, and think that their community is more endangered than themselves. The knowledge of the territory and danger sources, the unpredictability of flash floods and the feeling of safety induced by structural devices are the main elements which make the difference in shaping residents' perceptions. The study also demonstrated a widespread lack of adoption of preparatory measures among residents, together with a general low

  18. The impact of climate change on grain maize production over Europe - adaptation with different irrigation strategies

    NASA Astrophysics Data System (ADS)

    Ceglar, A.; Srivastava, A. K.; Chukaliev, O.; Duveiller, G.; Niemeyer, S.

    2013-12-01

    The spatial distribution of water deficit and maize yield deficit across Europe has been compared between current and expected climatic conditions in the near future (time window 2030). Maize yields and water requirements were simulated using the WOFOST (World Food Studies) crop growth model. In our study, the priority has been given to future projections of the A1B emission scenario produced within the ENSEMBLE project: HadRM3 RCM nested within the HADCM3 GCM (HADLEY) and HIRHAM5 RCM nested within ECHAM5 GCM (ECHAM). The two realizations can be considered as warm (HADLEY) and cold (ECHAM5) according to simulated temperature in the near future and therefore represent the extremes in air temperature change within those analyzed in ENSEMBLES project, allowing us to evaluate the largest range of uncertainty in weather inputs to the impact model. In addition, we also explored the advantages of different irrigation strategies for the target crop to offset climate change impacts. In wake of limited amount of water availability for agriculture purposes, we explored effectiveness of three different irrigation strategies on maize yield over Europe, namely full, deficit and supplemental irrigation. The results of our study indicate that the maize yield under rainfed conditions is expected to decrease over the Southern Europe as well as regions around the Black Sea during the 2030s under both climate model realizations. Water deficit is expected to increase especially in the Mediterranean, whereas slightly less in parts of Central and Western Europe. However, adaptation strategies followed in this study negate the detrimental effect of climate change and result in an increased maize yield. Three irrigation strategies have been simulated differing in timing of water application and in the total volume of water supplied during the growing season. The results show that yields, achieved using deficit and full irrigation strategies, are not significantly different. Hence, at least

  19. An enhancement strategy for integration of population health into medical school education: employing the framework developed by the Healthy People Curriculum Task Force.

    PubMed

    Kerkering, Kathryn Waldrop; Novick, Lloyd F

    2008-04-01

    The authors describe an enhancement strategy for integration of population health content into the medical school curriculum at The Brody School of Medicine at East Carolina University conducted in 2005-2006. The Clinical Prevention and Population Health Curriculum Framework developed by the Healthy People Curriculum Task Force served as the planning template for curriculum analysis. Key to success was the incorporation of population health as a "curriculum enhancement," as opposed to curricular expansion or substitution. Strategies included introduction of a Case-Based Series in Population-Oriented Prevention (C-POP) in the preclinical years; community assessments, home visits, and public health assignments in the family medicine and pediatrics clinical clerkships; and prevention history-taking. The Brody integrated curriculum included a wide range of topics and clinical experiences specific to prevention and population health; however, the coverage was uneven. Hybrid teaching cases were developed from four C-POP cases which were adapted to existing instructional materials. Students learned to define the determinants of health, disease burden in their community settings, and community strengths and obstacles specific to dealing with chronic conditions. Factors contributing to the successful integration of population health included a receptive primary care medical school, use of the Framework, analysis of gaps between the Framework and the existing curriculum, providing enhancements to the existing curriculum, employment of patient cases, and integrating population health into a variety of classroom and community medical learning experiences. This approach, as opposed to a separate and distinct course, seeks to reinforce the interconnectedness of communities, families, and individuals.

  20. Adaptations to migration in birds: behavioural strategies, morphology and scaling effects.

    PubMed

    Hedenström, Anders

    2008-01-27

    The annual life cycle of many birds includes breeding, moult and migration. All these processes are time and energy consuming and the extent of investment in any one may compromise the others. The output from breeding is of course the ultimate goal for all birds, while the investment in moult and migration should be selected so that lifetime fitness is maximized. In particular, long-distance migrants breeding at high latitudes face severe time pressures, which is a probable reason why natural selection has evolved efficient behaviours, physiological and morphological adaptations allowing the maximum possible migration speed. Optimal migration theory commonly assumes time minimization as an overall strategy, but the minimization of energy cost and predation risk may also be involved. Based on these assumptions, it is possible to derive adaptive behaviours such as when and at which fuel load a stopover site should be abandoned. I review some core components of optimal migration theory together with some key predictions. A review of accumulated empirical tests of the departure rule indicates that time minimization is an important component of the overall migration strategy, and hence gives support to the assumption about time-selected migration. I also briefly discuss how the optimal policy may be implemented by the bird by applying a set of simple rules. The time constraints on migrants increase with increasing body size. Some consequences of this are discussed.

  1. Adaptive strategies of the influenza virus polymerase for replication in humans.

    PubMed

    Mehle, Andrew; Doudna, Jennifer A

    2009-12-15

    Transmission of influenza viruses into the human population requires surmounting barriers to cross-species infection. Changes in the influenza polymerase overcome one such barrier. Viruses isolated from birds generally contain polymerases with the avian-signature glutamic acid at amino acid 627 in the PB2 subunit. These polymerases display restricted activity in human cells. An adaptive change in this residue from glutamic acid to the human-signature lysine confers high levels of polymerase activity in human cells. This mutation permits escape from a species-specific restriction factor that targets polymerases from avian viruses. A 2009 swine-origin H1N1 influenza A virus recently established a pandemic infection in humans, even though the virus encodes a PB2 with the restrictive glutamic acid at amino acid 627. We show here that the 2009 H1N1 virus has acquired second-site suppressor mutations in its PB2 polymerase subunit that convey enhanced polymerase activity in human cells. Introduction of this polymorphism into the PB2 subunit of a primary avian isolate also increased polymerase activity and viral replication in human and porcine cells. An alternate adaptive strategy has also been identified, whereby introduction of a human PA subunit into an avian polymerase overcomes restriction in human cells. These data reveal a strategy used by the 2009 H1N1 influenza A virus and identify other pathways by which avian and swine-origin viruses may evolve to enhance replication, and potentially pathogenesis, in humans.

  2. Strategies for flood hazard adaptation in drought affected regions of Afghanistan

    NASA Astrophysics Data System (ADS)

    Schleupner, Christine

    2010-05-01

    The development and management of water resources in Afghanistan are critically important for the economic development of the country. But Afghanistan presents a number of specific challenges in terms of water resource management and climate change impact assessment. Political instability and war has caused widespread devastation, insecurity, displacement, poverty and severe environmental degradation. Recent droughts have led to the collapse of many livelihoods, and poor national security restricts structured fieldwork. The recent restructuring and rebuilding of the state can be seen as opportunity to integrate climate change mitigation and adaptation measures into national, regional, and local planning. Governmental organizations are responsible to integrate climate change related issues and pro-active planning processes in water management and environmental considerations into relevant legislations, ministry and sector strategies. Integrated water resource management has been practically nonexistent during the last decades and consideration of climate change impacts are widely ignored in regional planning processes. However, flooding, landslides, drought, and extreme heat and freezing weather are already threatening the population. Climate models suggest that Afghanistan will be confronted by an increase of these events. Desertification and land degradation but also floods due to untimely rainfall are expected to broaden. Studies show that the impact of increasingly frequent flash floods may be amplified due to more rapid spring snow melt as a result of higher temperatures, combined with the downstream effects of land degradation, loss of vegetative cover and land mismanagement. It is further exacerbated by drought, which has the effect of hardening soils and reducing their permeability. In 2007 heavy floods already destroyed fields and harvests, killed livestock, damaged buildings, and claimed many lives. The intensified climatic conditions in Afghanistan will

  3. Lethal aggression in Pan is better explained by adaptive strategies than human impacts.

    PubMed

    Wilson, Michael L; Boesch, Christophe; Fruth, Barbara; Furuichi, Takeshi; Gilby, Ian C; Hashimoto, Chie; Hobaiter, Catherine L; Hohmann, Gottfried; Itoh, Noriko; Koops, Kathelijne; Lloyd, Julia N; Matsuzawa, Tetsuro; Mitani, John C; Mjungu, Deus C; Morgan, David; Muller, Martin N; Mundry, Roger; Nakamura, Michio; Pruetz, Jill; Pusey, Anne E; Riedel, Julia; Sanz, Crickette; Schel, Anne M; Simmons, Nicole; Waller, Michel; Watts, David P; White, Frances; Wittig, Roman M; Zuberbühler, Klaus; Wrangham, Richard W

    2014-09-18

    Observations of chimpanzees (Pan troglodytes) and bonobos (Pan paniscus) provide valuable comparative data for understanding the significance of conspecific killing. Two kinds of hypothesis have been proposed. Lethal violence is sometimes concluded to be the result of adaptive strategies, such that killers ultimately gain fitness benefits by increasing their access to resources such as food or mates. Alternatively, it could be a non-adaptive result of human impacts, such as habitat change or food provisioning. To discriminate between these hypotheses we compiled information from 18 chimpanzee communities and 4 bonobo communities studied over five decades. Our data include 152 killings (n = 58 observed, 41 inferred, and 53 suspected killings) by chimpanzees in 15 communities and one suspected killing by bonobos. We found that males were the most frequent attackers (92% of participants) and victims (73%); most killings (66%) involved intercommunity attacks; and attackers greatly outnumbered their victims (median 8:1 ratio). Variation in killing rates was unrelated to measures of human impacts. Our results are compatible with previously proposed adaptive explanations for killing by chimpanzees, whereas the human impact hypothesis is not supported.

  4. Adaptive Benefits of Storage Strategy and Dual AMPK/TOR Signaling in Metabolic Stress Response

    PubMed Central

    Pfeuty, Benjamin; Thommen, Quentin

    2016-01-01

    Cellular metabolism must ensure that supply of nutrient meets the biosynthetic and bioenergetic needs. Cells have therefore developed sophisticated signaling and regulatory pathways in order to cope with dynamic fluctuations of both resource and demand and to regulate accordingly diverse anabolic and catabolic processes. Intriguingly, these pathways are organized around a relatively small number of regulatory hubs, such as the highly conserved AMPK and TOR kinase families in eukaryotic cells. Here, the global metabolic adaptations upon dynamic environment are investigated using a prototypical model of regulated metabolism. In this model, the optimal enzyme profiles as well as the underlying regulatory architecture are identified by combining perturbation and evolutionary methods. The results reveal the existence of distinct classes of adaptive strategies, which differ in the management of storage reserve depending on the intensity of the stress and in the regulation of ATP-producing reaction depending on the nature of the stress. The regulatory architecture that optimally implements these adaptive features is characterized by a crosstalk between two specialized signaling pathways, which bears close similarities with the sensing and regulatory properties of AMPK and TOR pathways. PMID:27505075

  5. Responding to flow: How phytoplankton adapt migration strategies to tackle turbulence

    NASA Astrophysics Data System (ADS)

    Sengupta, Anupam; Carrara, Francesco; Stocker, Roman

    2014-11-01

    Phytoplankton are among the ocean's most important organisms and it has long been recognized that turbulence is a primary determinant of their fitness. Yet, mechanisms by which phytoplankton may adapt to turbulence have remained unknown. We present experiments that demonstrate how phytoplankton are capable of rapid adaptive behavior in response to fluid flow disturbances that mimic turbulence. Our study organism was the toxic marine alga Heterosigma akashiwo, known to exhibit ``negative gravitaxis,'' i . e . , to frequently migrate upwards against gravity. To mimic the effect of Kolmogorov-scale turbulent eddies, which expose cells to repeated reorientations, we observed H. akashiwo in a ``flip chamber,'' whose orientation was periodically flipped. Tracking of single cells revealed a striking, robust behavioral adaptation, whereby within tens of minutes half of the population reversed its direction of migration to swim downwards, demonstrating an active response to fluid flow. Using confocal microscopy, we provide a physiological rationalization of this behavior in terms of the redistribution of internal organelles, and speculate on the motives for this bet-hedging-type strategy. This work suggests that the effects of fluid flow - not just passive but also active - on plankton represents a rich area of investigation with considerable implications for some of earth's most important organisms.

  6. Real-time nutrient monitoring in rivers: adaptive sampling strategies, technological challenges and future directions

    NASA Astrophysics Data System (ADS)

    Blaen, Phillip; Khamis, Kieran; Lloyd, Charlotte; Bradley, Chris

    2016-04-01

    Excessive nutrient concentrations in river waters threaten aquatic ecosystem functioning and can pose substantial risks to human health. Robust monitoring strategies are therefore required to generate reliable estimates of river nutrient loads and to improve understanding of the catchment processes that drive spatiotemporal patterns in nutrient fluxes. Furthermore, these data are vital for prediction of future trends under changing environmental conditions and thus the development of appropriate mitigation measures. In recent years, technological developments have led to an increase in the use of continuous in-situ nutrient analysers, which enable measurements at far higher temporal resolutions than can be achieved with discrete sampling and subsequent laboratory analysis. However, such instruments can be costly to run and difficult to maintain (e.g. due to high power consumption and memory requirements), leading to trade-offs between temporal and spatial monitoring resolutions. Here, we highlight how adaptive monitoring strategies, comprising a mixture of temporal sample frequencies controlled by one or more 'trigger variables' (e.g. river stage, turbidity, or nutrient concentration), can advance our understanding of catchment nutrient dynamics while simultaneously overcoming many of the practical and economic challenges encountered in typical in-situ river nutrient monitoring applications. We present examples of short-term variability in river nutrient dynamics, driven by complex catchment behaviour, which support our case for the development of monitoring systems that can adapt in real-time to rapid environmental changes. In addition, we discuss the advantages and disadvantages of current nutrient monitoring techniques, and suggest new research directions based on emerging technologies and highlight how these might improve: 1) monitoring strategies, and 2) understanding of linkages between catchment processes and river nutrient fluxes.

  7. Multimodal Optimization by Covariance Matrix Self-Adaptation Evolution Strategy with Repelling Subpopulations.

    PubMed

    Ahrari, Ali; Deb, Kalyanmoy; Preuss, Mike

    2016-04-12

    During the recent decades, many niching methods have been proposed and empirically verified on some available test problems. They often rely on some particular assumptions associated with the distribution, shape, and size of the basins, which can seldom be made in practical optimization problems. This study utilizes several existing concepts and techniques, such as taboo points, normalized Mahalanobis distance, and the Ursem's hill-valley function in order to develop a new tool for multimodal optimization, which does not make any of these assumptions. In the proposed method, several subpopulations explore the search space in parallel. Offspring of a subpopulation are forced to maintain a sufficient distance to the center of fitter subpopulations and the previously identified basins, which are marked as taboo points. The taboo points repel the subpopulation to prevent convergence to the same basin. A strategy to update the repelling power of the taboo points is proposed to address the challenge of basins of dissimilar size. The local shape of a basin is also approximated by the distribution of the subpopulation members converging to that basin. The proposed niching strategy is incorporated into the covariance matrix self-adaptation evolution strategy (CMSA-ES), a potent global optimization method. The resultant method, called the covariance matrix self-adaptation with repelling subpopulations (RS-CMSA), is assessed and compared to several state-of-the-art niching methods on a standard test suite for multimodal optimization. An organized procedure for parameter setting is followed which assumes a rough estimation of the desired/expected number of minima available. Performance sensitivity to the accuracy of this estimation is also studied by introducing the concept of robust mean peak ratio. Based on the numerical results using the available and the introduced performance measures, RS-CMSA emerges as the most successful method when robustness and efficiency are

  8. Adapting to conversation with semantic dementia: using enactment as a compensatory strategy in everyday social interaction

    PubMed Central

    Kindell, Jacqueline; Sage, Karen; Keady, John; Wilkinson, Ray

    2014-01-01

    Background Studies to date in semantic dementia have examined communication in clinical or experimental settings. There is a paucity of research describing the everyday interactional skills and difficulties seen in this condition. Aims To examine the everyday conversation, at home, of an individual with semantic dementia. Methods & Procedures A 71-year-old man with semantic dementia and his wife were given a video camera and asked to record natural conversation in the home situation with no researcher present. Recordings were also made in the home environment, with the individual with semantic dementia in conversation with a member of the research team. Conversation analysis was used to transcribe and analyse the data. Recurring features were noted to identify conversational patterns. Outcomes & Results Analysis demonstrated a repeated practice by the speaker with semantic dementia of acting out a diversity of scenes (enactment). As such, the speaker regularly used direct reported speech along with paralinguistic features (such as pitch and loudness) and non-vocal communication (such as body posture, pointing and facial expression) as an adaptive strategy to communicate with others in conversation. Conclusions & Implications This case shows that while severe difficulties may be present on neuropsychological assessment, relatively effective communicative strategies may be evident in conversation. A repeated practice of enactment in conversation allowed this individual to act out, or perform what he wanted to say, allowing him to generate a greater level of meaningful communication than his limited vocabulary alone could achieve through describing the events concerned. Such spontaneously acquired adaptive strategies require further attention in both research and clinical settings in semantic dementia and analysis of interaction in this condition, using conversation analysis, may be helpful. PMID:24033649

  9. Adaptive strategies for post-renal handling of urine in birds.

    PubMed

    Laverty, Gary; Skadhauge, Erik

    2008-03-01

    Birds are a diverse vertebrate class in terms of diet and habitat, but they share several common physiological features, including the use of uric acid as the major nitrogenous waste product and the lack of a urinary bladder. Instead, ureteral urine refluxes from the urodeum into the more proximal coprodeum and portions of the hindgut (colon or rectum and ceca). This presents a potential problem in that hyperosmotic ureteral urine in contact with the permeable epithelia of these tissues would counteract renal osmotic work. This review describes and provides examples of different strategies used by avian species to balance renal and post-renal changes in urine composition. The strategies described include: 1. a "reptilian" mode, with moderate renal concentrating ability, but high rates of post-renal salt and water resorption; 2. the "mammalian" strategy, in which the coprodeum effectively functions like a mammalian urinary bladder, preserving the osmotic concentrating work of the kidney; 3. an interaction strategy, in which post-renal transport processes are hormonally regulated in order to optimize renal function under varying conditions of salt or water stress; 4. the salt gland strategy seen in marine or estuarine birds with functional salt glands, in which post-renal transport mechanisms are used to conserve urinary water and to recycle excess NaCl to the nasal salt glands. Finally, we also describe some features of an as-yet unstudied group of birds, the birds of prey. At least some species in this group are relatively good renal concentrators, and would be predicted to have post-renal mechanisms to preserve this work. This new synthesis illustrates the marked diversity of adaptive mechanisms used by avian species to maintain osmotic homeostasis.

  10. The QoE implications of ultra-high definition video adaptation strategies

    NASA Astrophysics Data System (ADS)

    Nightingale, James; Awobuluyi, Olatunde; Wang, Qi; Alcaraz-Calero, Jose M.; Grecos, Christos

    2016-04-01

    As the capabilities of high-end consumer devices increase, streaming and playback of Ultra-High Definition (UHD) is set to become commonplace. The move to these new, higher resolution, video services is one of the main factors contributing to the predicted continuation of growth in video related traffic in the Internet. This massive increases in bandwidth requirement, even when mitigated by the use of new video compression standards such as H.265, will place an ever-increasing burden on network service providers. This will be especially true in mobile environments where users have come to expect ubiquitous access to content. Consequently, delivering UHD and Full UHD (FUHD) video content is one of the key drivers for future Fifth Generation (5G) mobile networks. One often voiced, but as yet unanswered question, is whether users of mobile devices with modest screen sizes (e.g. smartphones or smaller tablet) will actually benefit from consuming the much higher bandwidth required to watch online UHD video, in terms of an improved user experience. In this paper, we use scalable H.265 encoded video streams to conduct a subjective evaluation of the impact on a user's perception of video quality across a comprehensive range of adaptation strategies, covering each of the three adaptation domains, for UHD and FUHD video. The results of our subjective study provide insightful and useful indications of which methods of adapting UHD and FUHD streams have the least impact on user's perceived QoE. In particular, it was observed that, in over 70% of cases, users were unable to distinguish between full HD (1080p) and UHD (4K) videos when they were unaware of which version was being shown to them. Our results from this evaluation can be used to provide adaptation rule sets that will facilitate fast, QoE aware in-network adaptation of video streams in support of realtime adaptation objectives. Undoubtedly they will also promote discussion around how network service providers manage

  11. Adaptation.

    PubMed

    Broom, Donald M

    2006-01-01

    The term adaptation is used in biology in three different ways. It may refer to changes which occur at the cell and organ level, or at the individual level, or at the level of gene action and evolutionary processes. Adaptation by cells, especially nerve cells helps in: communication within the body, the distinguishing of stimuli, the avoidance of overload and the conservation of energy. The time course and complexity of these mechanisms varies. Adaptive characters of organisms, including adaptive behaviours, increase fitness so this adaptation is evolutionary. The major part of this paper concerns adaptation by individuals and its relationships to welfare. In complex animals, feed forward control is widely used. Individuals predict problems and adapt by acting before the environmental effect is substantial. Much of adaptation involves brain control and animals have a set of needs, located in the brain and acting largely via motivational mechanisms, to regulate life. Needs may be for resources but are also for actions and stimuli which are part of the mechanism which has evolved to obtain the resources. Hence pigs do not just need food but need to be able to carry out actions like rooting in earth or manipulating materials which are part of foraging behaviour. The welfare of an individual is its state as regards its attempts to cope with its environment. This state includes various adaptive mechanisms including feelings and those which cope with disease. The part of welfare which is concerned with coping with pathology is health. Disease, which implies some significant effect of pathology, always results in poor welfare. Welfare varies over a range from very good, when adaptation is effective and there are feelings of pleasure or contentment, to very poor. A key point concerning the concept of individual adaptation in relation to welfare is that welfare may be good or poor while adaptation is occurring. Some adaptation is very easy and energetically cheap and

  12. Development and Adaptation of an Employment-Integration Program for People Who Are Visually Impaired in Quebec, Canada

    ERIC Educational Resources Information Center

    Wittich, Walter; Watanabe, Donald H.; Scully, Lizabeth; Bergevin , Martin

    2013-01-01

    Introduction: In the Province of Quebec, Canada, it is estimated that only about one-third of working-age adults with visual impairments are part of the workforce, despite ongoing efforts of rehabilitation and government agencies to integrate these individuals. The present article describes the development and adaptation of a pre-employment…

  13. Climate Change Predictions and Adaption Strategies for Coastal NASA Langley Research Center

    NASA Astrophysics Data System (ADS)

    De Young, R.

    2012-12-01

    Climate change could significantly impact the personal and operations of federal coastal laboratories. The Goddard Institute for Space Studies has made downscaled climate projections for Hampton Roads, Virginia a coastal region which includes NASA Langley Research Center (LaRC). These projections are being used to formulate adaptation and mitigation strategies to reduce climate change impacts at the center. Sea level rise and hurricanes will have significant impacts on LaRC and strategies such as surge modeling and tide gauge measurements and now underway. A proposed windbreak will reduce the impact of hurricane winds on center infrastructure. Disease vectors such as mosquitoes and ticks are being monitored and studied for their response to climate change. LaRC has significant forest and ecosystems which will be impacted by climate change and these impacts are being quantified. Mitigation strategies are being proposed such as the design of a 3 MW solar photovoltaic array to protect the center from brownouts and loss of power to critical missions. These and other programs will be discussed to reduce climate change impacts and allow LaRC to accomplish its mission into the next century.

  14. Complementing institutional with localised strategies for climate change adaptation: a South-North comparison.

    PubMed

    Wamsler, Christine; Lawson, Nigel

    2012-01-01

    Climate change and disasters pose a serious risk to sustainable development. In the South, local coping strategies are an important element of adaptation to climate and disaster risk. Such strategies have emerged because of the limited assistance provided by urban actors and associated social security and governance systems. In the North, in contrast, local coping strategies are comparatively poorly developed. However, the extent of the changing climatic conditions is also reducing the capacity of Northern institutions to deal with climatic extremes and variability, which emphasises the need for more local-level engagement in the North. This paper analyses the differences in local and institutional responses to climate change and disasters in a Southern and a Northern city (San Salvador, El Salvador, and Manchester, United Kingdom, respectively), and highlights how the lessons learned might be translated into an improved distributed governance system; that is, an 'integrated engagement model', where local and institutionalised responses support rather than hinder each other, as is currently the case.

  15. An Incremental Target-Adapted Strategy for Active Geometric Calibration of Projector-Camera Systems

    PubMed Central

    Chen, Chia-Yen; Chien, Hsiang-Jen

    2013-01-01

    The calibration of a projector-camera system is an essential step toward accurate 3-D measurement and environment-aware data projection applications, such as augmented reality. In this paper we present a two-stage easy-to-deploy strategy for robust calibration of both intrinsic and extrinsic parameters of a projector. Two key components of the system are the automatic generation of projected light patterns and the incremental calibration process. Based on the incremental strategy, the calibration process first establishes a set of initial parameters, and then it upgrades these parameters incrementally using the projection and captured images of dynamically-generated calibration patterns. The scene-driven light patterns allow the system to adapt itself to the pose of the calibration target, such that the difficulty in feature detection is greatly lowered. The strategy forms a closed-loop system that performs self-correction as more and more observations become available. Compared to the conventional method, which requires a time-consuming process for the acquisition of dense pixel correspondences, the proposed method deploys a homography-based coordinate computation, allowing the calibration time to be dramatically reduced. The experimental results indicate that an improvement of 70% in reprojection errors is achievable and 95% of the calibration time can be saved. PMID:23435056

  16. Comparative Proteogenomics of Twelve Roseobacter Exoproteomes Reveals Different Adaptive Strategies Among These Marine Bacteria*

    PubMed Central

    Christie-Oleza, Joseph Alexander; Piña-Villalonga, Juana Maria; Bosch, Rafael; Nogales, Balbina; Armengaud, Jean

    2012-01-01

    Roseobacters are generalist bacteria abundantly found in the oceans. Because little is known on how marine microorganisms interact in association or competition, we focused our attention on the microbial exoproteome, a key component in their interaction with extracellular milieu. Here we present a comparative analysis of the theoretically encoded exoproteome of twelve members of the Roseobacter group validated by extensive comparative proteogenomics. In silico analysis revealed that 30% of the encoded proteome of these microorganisms could be exported. The ratio of the different protein categories varied in accordance to the ecological distinctness of each strain, a trait reinforced by quantitative proteomics data. Despite the interspecies variations found, the most abundantly detected proteins by shotgun proteomics were from transporter, adhesion, motility, and toxin-like protein categories, defining four different plausible adaptive strategies within the Roseobacter group. In some strains the toxin-secretion strategy was over-represented with repeats-in-toxin-like proteins. Our results show that exoproteomes strongly depend on bacterial trophic strategy and can slightly change because of culture conditions. Simulated natural conditions and the effect of the indigenous microbial community on the exoproteome of Ruegeria pomeroyi DSS-3 were also assayed. Interestingly, we observed a significant depletion of the toxin-like proteins usually secreted by R. pomeroyi DSS-3 when grown in presence of a natural community sampled from a Mediterranean Sea port. The significance of this specific fraction of the exoproteome is discussed. PMID:22122883

  17. Adhesive Sociocultural Adaptation of Korean Immigrants in the U.S.: An Alternative Strategy of Minority Adaptation.

    ERIC Educational Resources Information Center

    Hurh, Won Moo; Kim, Kwang Chung

    1984-01-01

    "Adhesive adaptation" occurs when aspects of a new culture and social relations with members of the host society are added on to immigrants' traditional culture and social networks, without replacing or modifying any significant part of the old. Interviews with 615 Korean immigrants empirically confirmed this adaptation model. (Author/KH)

  18. 15 Gbit/s indoor optical wireless systems employing fast adaptation and imaging reception in a realistic environment

    NASA Astrophysics Data System (ADS)

    Alsaadi, Fuad E.

    2016-03-01

    Optical wireless systems are promising candidates for next-generation indoor communication networks. Optical wireless technology offers freedom from spectrum regulations and, compared to current radio-frequency networks, higher data rates and increased security. This paper presents a fast adaptation method for multibeam angle and delay adaptation systems and a new spot-diffusing geometry, and also considers restrictions needed for complying with eye safety regulations. The fast adaptation algorithm reduces the computational load required to reconfigure the transmitter in the case of transmitter and/or receiver mobility. The beam clustering approach enables the transmitter to assign power to spots within the pixel's field of view (FOV) and increases the number of such spots. Thus, if the power per spot is restricted to comply with eye safety standards, the new approach, in which more spots are visible within the FOV of the pixel, leads to enhanced signal-to-noise ratio (SNR). Simulation results demonstrate that the techniques proposed in this paper lead to SNR improvements that enable reliable operation at data rates as high as 15 Gbit/s. These results are based on simulation and not on actual measurements or experiments.

  19. Adaptive strategies in nocturnally migrating insects and songbirds: contrasting responses to wind.

    PubMed

    Chapman, Jason W; Nilsson, Cecilia; Lim, Ka S; Bäckman, Johan; Reynolds, Don R; Alerstam, Thomas

    2016-01-01

    Animals that use flight as their mode of transportation must cope with the fact that their migration and orientation performance is strongly affected by the flow of the medium they are moving in, that is by the winds. Different strategies can be used to mitigate the negative effects and benefit from the positive effects of a moving flow. The strategies an animal can use will be constrained by the relationship between the speed of the flow and the speed of the animal's own propulsion in relation to the surrounding air. Here we analyse entomological and ornithological radar data from north-western Europe to investigate how two different nocturnal migrant taxa, the noctuid moth Autographa gamma and songbirds, deal with wind by analysing variation in resulting flight directions in relation to the wind-dependent angle between the animal's heading and track direction. Our results, from fixed locations along the migratory journey, reveal different global strategies used by moths and songbirds during their migratory journeys. As expected, nocturnally migrating moths experienced a greater degree of wind drift than nocturnally migrating songbirds, but both groups were more affected by wind in autumn than in spring. The songbirds' strategies involve elements of both drift and compensation, providing some benefits from wind in combination with destination and time control. In contrast, moths expose themselves to a significantly higher degree of drift in order to obtain strong wind assistance, surpassing the songbirds in mean ground speed, at the cost of a comparatively lower spatiotemporal migratory precision. Moths and songbirds show contrasting but adaptive responses to migrating through a moving flow, which are fine-tuned to the respective flight capabilities of each group in relation to the wind currents they travel within.

  20. Adapting to aging losses: do resources facilitate strategies of selection, compensation, and optimization in everyday functioning?

    PubMed

    Lang, Frieder R; Rieckmann, Nina; Baltes, Margret M

    2002-11-01

    Previous cross-sectional research has shown that older people who are rich in sensorimotor-cognitive and social-personality resources are better functioning in everyday life and exhibit fewer negative age differences than resource-poor adults. Longitudinal data from the Berlin Aging Study was used to examine these findings across a 4-year time interval and to compare cross-sectional indicators of adaptive everyday functioning among survivors and nonsurvivors. Apart from their higher survival rate, resource-rich older people (a) invest more social time with their family members, (b) reduce the diversity of activities within the most salient leisure domain, (c) sleep more often and longer during daytime, and (d) increase the variability of time investments across activities after 4 years. Overall, findings suggest a greater use of selection, compensation, and optimization strategies in everyday functioning among resource-rich older adults as compared with resource-poor older adults.

  1. Weighted log-rank statistic to compare shared-path adaptive treatment strategies.

    PubMed

    Kidwell, Kelley M; Wahed, Abdus S

    2013-04-01

    Adaptive treatment strategies (ATSs) more closely mimic the reality of a physician's prescription process where the physician prescribes a medication to his/her patient, and based on that patient's response to the medication, modifies the treatment. Two-stage randomization designs, more generally, sequential multiple assignment randomization trial designs, are useful to assess ATSs where the interest is in comparing the entire sequence of treatments, including the patient's intermediate response. In this paper, we introduce the notion of shared-path and separate-path ATSs and propose a weighted log-rank statistic to compare overall survival distributions of multiple two-stage ATSs, some of which may be shared-path. Large sample properties of the statistic are derived and the type I error rate and power of the test are compared with the standard log-rank test through simulation.

  2. Adaptive strategies of remote systems operators exposed to perturbed camera-viewing conditions

    NASA Technical Reports Server (NTRS)

    Stuart, Mark A.; Manahan, Meera K.; Bierschwale, John M.; Sampaio, Carlos E.; Legendre, A. J.

    1991-01-01

    This report describes a preliminary investigation of the use of perturbed visual feedback during the performance of simulated space-based remote manipulation tasks. The primary objective of this NASA evaluation was to determine to what extent operators exhibit adaptive strategies which allow them to perform these specific types of remote manipulation tasks more efficiently while exposed to perturbed visual feedback. A secondary objective of this evaluation was to establish a set of preliminary guidelines for enhancing remote manipulation performance and reducing the adverse effects. These objectives were accomplished by studying the remote manipulator performance of test subjects exposed to various perturbed camera-viewing conditions while performing a simulated space-based remote manipulation task. Statistical analysis of performance and subjective data revealed that remote manipulation performance was adversely affected by the use of perturbed visual feedback and performance tended to improve with successive trials in most perturbed viewing conditions.

  3. Comparison of adaptive treatment strategies based on longitudinal outcomes in sequential multiple assignment randomized trials.

    PubMed

    Li, Zhiguo

    2017-02-10

    In sequential multiple assignment randomized trials, longitudinal outcomes may be the most important outcomes of interest because this type of trials is usually conducted in areas of chronic diseases or conditions. We propose to use a weighted generalized estimating equation (GEE) approach to analyzing data from such type of trials for comparing two adaptive treatment strategies based on generalized linear models. Although the randomization probabilities are known, we consider estimated weights in which the randomization probabilities are replaced by their empirical estimates and prove that the resulting weighted GEE estimator is more efficient than the estimators with true weights. The variance of the weighted GEE estimator is estimated by an empirical sandwich estimator. The time variable in the model can be linear, piecewise linear, or more complicated forms. This provides more flexibility that is important because, in the adaptive treatment setting, the treatment changes over time and, hence, a single linear trend over the whole period of study may not be practical. Simulation results show that the weighted GEE estimators of regression coefficients are consistent regardless of the specification of the correlation structure of the longitudinal outcomes. The weighted GEE method is then applied in analyzing data from the Clinical Antipsychotic Trials of Intervention Effectiveness. Copyright © 2016 John Wiley & Sons, Ltd.

  4. Strategies to overcome photobleaching in algorithm-based adaptive optics for nonlinear in-vivo imaging.

    PubMed

    Caroline Müllenbroich, M; McGhee, Ewan J; Wright, Amanda J; Anderson, Kurt I; Mathieson, Keith

    2014-01-01

    We have developed a nonlinear adaptive optics microscope utilizing a deformable membrane mirror (DMM) and demonstrated its use in compensating for system- and sample-induced aberrations. The optimum shape of the DMM was determined with a random search algorithm optimizing on either two photon fluorescence or second harmonic signals as merit factors. We present here several strategies to overcome photobleaching issues associated with lengthy optimization routines by adapting the search algorithm and the experimental methodology. Optimizations were performed on extrinsic fluorescent dyes, fluorescent beads loaded into organotypic tissue cultures and the intrinsic second harmonic signal of these cultures. We validate the approach of using these preoptimized mirror shapes to compile a robust look-up table that can be applied for imaging over several days and through a variety of tissues. In this way, the photon exposure to the fluorescent cells under investigation is limited to imaging. Using our look-up table approach, we show signal intensity improvement factors ranging from 1.7 to 4.1 in organotypic tissue cultures and freshly excised mouse tissue. Imaging zebrafish in vivo, we demonstrate signal improvement by a factor of 2. This methodology is easily reproducible and could be applied to many photon starved experiments, for example fluorescent life time imaging, or when photobleaching is a concern.

  5. Wind speed variability and adaptation strategies in coastal areas of the Pacific Northwest

    NASA Astrophysics Data System (ADS)

    Griffin, Bradford

    Overall, previous wind speed studies in the Pacific Northwest (PNW) present conflicting results for wind speed trends (both increasing and decreasing) in relation to climate drivers. This study fills a gap in the understanding of PNW wind behaviour by: determining if relationships exist between wind speed distributions, ocean/atmospheric climate indices, and monitoring station-specific attributes; assessing the robustness of relationships for forecasting wind speeds within the study area; and presenting adaptation strategies to wind damage. Analyzing the quantiles of the strongly skewed (non-normal) wind speed distributions reveals different behaviours for average and extreme wind speeds and significantly stronger winds at coastal locations compared with sites further inland. Coast locations appear to follow a nine-year cyclic pattern, while mainland sites have a downward wind speed trend. This finding has important implications for wind research and infrastructure or ecosystem planning in areas such as wind energy feasibility studies and timing management activities. Keywords: Wind speed; Pacific Northwest; Quantiles; Linear mixed-effects model; Variability; Adaptation; Climate change.

  6. Climate Variability, Andean Livelihood Strategies, Development and Adaptation in the Andean Region

    NASA Astrophysics Data System (ADS)

    Valdivia, C.; Quiroz, R.; Zorogastua, P.; Baigorrea, G.

    2002-05-01

    Development programs in the Andes have failed to recognize climate variability as an element that is crucial to the adoption of new alternatives. Dairy, potatoes, improved sheep, forages are all part of the history of development in this region. A combination of climate variability, changes in the economy, the political environment, and land tenure reform shape rural livelihoods and welfare. Diversification, linking to markets, and networking are some elements that contribute to the resilience of families in the Andes. Strategies change, are flexible, and may incorporate non-agricultural activities. While some farmers are able to improve their welfare through the life cycle, others become poorer. Climate variability increases the vulnerability of some groups; in other cases, because of diversification and assets, households build economic portfolios that are more resilient to the elements. The many projects provide insights into how in the long run households improve their environment, hinting at mechanisms to adapt to climate change. In order to understand changing composition of portfolios in future scenarios of spatial heterogeneous areas such as mountains (Andes), estimates of models predicting climate change at a global scale are not useful because their resolution. Therefore, downscaling tools are useful. Spatial heterogeneity is assessed through agroecozoning. Both production and the impact on some environmental indicators are simulated through process-based models, for the Ilave-Huenque watershed in Peru that help in discussing scenarios of adaptation.

  7. Recruiting hard-to-reach United States population sub-groups via adaptations of snowball sampling strategy

    PubMed Central

    Sadler, Georgia Robins; Lee, Hau-Chen; Seung-Hwan Lim, Rod; Fullerton, Judith

    2011-01-01

    Nurse researchers and educators often engage in outreach to narrowly defined populations. This article offers examples of how variations on the snowball sampling recruitment strategy can be applied in the creation of culturally appropriate, community-based information dissemination efforts related to recruitment to health education programs and research studies. Examples from the primary author’s program of research are provided to demonstrate how adaptations of snowball sampling can be effectively used in the recruitment of members of traditionally underserved or vulnerable populations. The adaptation of snowball sampling techniques, as described in this article, helped the authors to gain access to each of the more vulnerable population groups of interest. The use of culturally sensitive recruitment strategies is both appropriate and effective in enlisting the involvement of members of vulnerable populations. Adaptations of snowball sampling strategies should be considered when recruiting participants for education programs or subjects for research studies when recruitment of a population based sample is not essential. PMID:20727089

  8. Effect of a large gaming neighborhood and a strategy adaptation neighborhood for bolstering network reciprocity in a prisoner's dilemma game

    NASA Astrophysics Data System (ADS)

    Ogasawara, Takashi; Tanimoto, Jun; Fukuda, Eriko; Hagishima, Aya; Ikegaya, Naoki

    2014-12-01

    In 2 × 2 prisoner's dilemma (PD) games, network reciprocity is one mechanism for adding social viscosity, leading to a cooperative equilibrium. In this paper, we explain how gaming neighborhoods and strategy-adaptation neighborhoods affect network reciprocity independently in spatial PD games. We explore an appropriate range of strategy adaptation neighborhoods as opposed to the conventional method of making the gaming and strategy adaptation neighborhoods coincide to enhance the level of cooperation. In cases of expanding gaming neighborhoods, network reciprocity falls to a low level relative to the conventional setting. In the discussion below, which is based on the results of our simulation, we explore how these enhancements come about. Essentially, varying the range of the neighborhoods influences how cooperative clusters form and expand in the evolutionary process.

  9. An Integrated Framework for Assessing Vulnerability to Climate Change and Developing Adaptation Strategies for Coffee Growing Families in Mesoamerica

    PubMed Central

    Baca, María; Läderach, Peter; Haggar, Jeremy; Schroth, Götz; Ovalle, Oriana

    2014-01-01

    The Mesoamerican region is considered to be one of the areas in the world most vulnerable to climate change. We developed a framework for quantifying the vulnerability of the livelihoods of coffee growers in Mesoamerica at regional and local levels and identify adaptation strategies. Following the Intergovernmental Panel on Climate Change (IPCC) concepts, vulnerability was defined as the combination of exposure, sensitivity and adaptive capacity. To quantify exposure, changes in the climatic suitability for coffee and other crops were predicted through niche modelling based on historical climate data and locations of coffee growing areas from Mexico, Guatemala, El Salvador and Nicaragua. Future climate projections were generated from 19 Global Circulation Models. Focus groups were used to identify nine indicators of sensitivity and eleven indicators of adaptive capacity, which were evaluated through semi-structured interviews with 558 coffee producers. Exposure, sensitivity and adaptive capacity were then condensed into an index of vulnerability, and adaptation strategies were identified in participatory workshops. Models predict that all target countries will experience a decrease in climatic suitability for growing Arabica coffee, with highest suitability loss for El Salvador and lowest loss for Mexico. High vulnerability resulted from loss in climatic suitability for coffee production and high sensitivity through variability of yields and out-migration of the work force. This was combined with low adaptation capacity as evidenced by poor post harvest infrastructure and in some cases poor access to credit and low levels of social organization. Nevertheless, the specific contributors to vulnerability varied strongly among countries, municipalities and families making general trends difficult to identify. Flexible strategies for adaption are therefore needed. Families need the support of government and institutions specialized in impacts of climate change and

  10. An integrated framework for assessing vulnerability to climate change and developing adaptation strategies for coffee growing families in Mesoamerica.

    PubMed

    Baca, María; Läderach, Peter; Haggar, Jeremy; Schroth, Götz; Ovalle, Oriana

    2014-01-01

    The Mesoamerican region is considered to be one of the areas in the world most vulnerable to climate change. We developed a framework for quantifying the vulnerability of the livelihoods of coffee growers in Mesoamerica at regional and local levels and identify adaptation strategies. Following the Intergovernmental Panel on Climate Change (IPCC) concepts, vulnerability was defined as the combination of exposure, sensitivity and adaptive capacity. To quantify exposure, changes in the climatic suitability for coffee and other crops were predicted through niche modelling based on historical climate data and locations of coffee growing areas from Mexico, Guatemala, El Salvador and Nicaragua. Future climate projections were generated from 19 Global Circulation Models. Focus groups were used to identify nine indicators of sensitivity and eleven indicators of adaptive capacity, which were evaluated through semi-structured interviews with 558 coffee producers. Exposure, sensitivity and adaptive capacity were then condensed into an index of vulnerability, and adaptation strategies were identified in participatory workshops. Models predict that all target countries will experience a decrease in climatic suitability for growing Arabica coffee, with highest suitability loss for El Salvador and lowest loss for Mexico. High vulnerability resulted from loss in climatic suitability for coffee production and high sensitivity through variability of yields and out-migration of the work force. This was combined with low adaptation capacity as evidenced by poor post harvest infrastructure and in some cases poor access to credit and low levels of social organization. Nevertheless, the specific contributors to vulnerability varied strongly among countries, municipalities and families making general trends difficult to identify. Flexible strategies for adaption are therefore needed. Families need the support of government and institutions specialized in impacts of climate change and

  11. A Map-Based Cloning Strategy Employing a Residual Heterozygous Line Reveals that the GIGANTEA Gene Is Involved in Soybean Maturity and Flowering

    PubMed Central

    Watanabe, Satoshi; Xia, Zhengjun; Hideshima, Rumiko; Tsubokura, Yasutaka; Sato, Shusei; Yamanaka, Naoki; Takahashi, Ryoji; Anai, Toyoaki; Tabata, Satoshi; Kitamura, Keisuke; Harada, Kyuya

    2011-01-01

    Flowering is indicative of the transition from vegetative to reproductive phase, a critical event in the life cycle of plants. In soybean (Glycine max), a flowering quantitative trait locus, FT2, corresponding to the maturity locus E2, was detected in recombinant inbred lines (RILs) derived from the varieties “Misuzudaizu” (ft2/ft2; JP28856) and “Moshidou Gong 503” (FT2/FT2; JP27603). A map-based cloning strategy using the progeny of a residual heterozygous line (RHL) from the RIL was employed to isolate the gene responsible for this quantitative trait locus. A GIGANTEA ortholog, GmGIa (Glyma10g36600), was identified as a candidate gene. A common premature stop codon at the 10th exon was present in the Misuzudaizu allele and in other near isogenic lines (NILs) originating from Harosoy (e2/e2; PI548573). Furthermore, a mutant line harboring another premature stop codon showed an earlier flowering phenotype than the original variety, Bay (E2/E2; PI553043). The e2/e2 genotype exhibited elevated expression of GmFT2a, one of the florigen genes that leads to early flowering. The effects of the E2 allele on flowering time were similar among NILs and constant under high (43°N) and middle (36°N) latitudinal regions in Japan. These results indicate that GmGIa is the gene responsible for the E2 locus and that a null mutation in GmGIa may contribute to the geographic adaptation of soybean. PMID:21406680

  12. Self adaptive solution strategies: Locally bound constrained Newton Raphson solution algorithms

    NASA Technical Reports Server (NTRS)

    Padovan, Joe

    1991-01-01

    A summary is given of strategies which enable the automatic adjustment of the constraint surfaces recently used to extend the range and numerical stability/efficiency of nonlinear finite element equation solvers. In addition to handling kinematic and material induced nonlinearity, both pre-and postbuckling behavior can be treated. The scheme employs localized bounds on various hierarchical partitions of the field variables. These are used to resize, shape, and orient the global constraint surface, thereby enabling essentially automatic load/deflection incrementation. Due to the generality of the approach taken, it can be implemented in conjunction with the constraints of an arbitrary functional type. To benchmark the method, several numerical experiments are presented. These include problems involving kinematic and material nonlinearity, as well as pre- and postbuckling characteristics. Also included is a list of papers published in the course of the work.

  13. The effects of vehicular gap changes with memory on traffic flow in cooperative adaptive cruise control strategy

    NASA Astrophysics Data System (ADS)

    Yu, Shaowei; Shi, Zhongke

    2015-06-01

    To evaluate the impacts of new influence factor in cooperative adaptive cruise control strategy on the dynamic characteristics of traffic flow, an improved cooperative car-following model considering multiple vehicular gap changes with memory is developed to study the influences of multiple vehicular gap changes with memory on each car's speed, acceleration and relative distance. Some numerical simulations are carried out and the results show that considering multiple vehicular gap changes with memory in designing the cooperative adaptive cruise control strategy can improve the stability of traffic flow and reduce the accidental probability.

  14. The Active Side of Stereopsis: Fixation Strategy and Adaptation to Natural Environments

    PubMed Central

    Gibaldi, Agostino; Canessa, Andrea; Sabatini, Silvio P.

    2017-01-01

    Depth perception in near viewing strongly relies on the interpretation of binocular retinal disparity to obtain stereopsis. Statistical regularities of retinal disparities have been claimed to greatly impact on the neural mechanisms that underlie binocular vision, both to facilitate perceptual decisions and to reduce computational load. In this paper, we designed a novel and unconventional approach in order to assess the role of fixation strategy in conditioning the statistics of retinal disparity. We integrated accurate realistic three-dimensional models of natural scenes with binocular eye movement recording, to obtain accurate ground-truth statistics of retinal disparity experienced by a subject in near viewing. Our results evidence how the organization of human binocular visual system is finely adapted to the disparity statistics characterizing actual fixations, thus revealing a novel role of the active fixation strategy over the binocular visual functionality. This suggests an ecological explanation for the intrinsic preference of stereopsis for a close central object surrounded by a far background, as an early binocular aspect of the figure-ground segregation process. PMID:28317909

  15. An adaptive strategy for reducing Feral Cat predation on endangered hawaiian birds

    USGS Publications Warehouse

    Hess, S.C.; Banko, P.C.; Hansen, H.

    2009-01-01

    Despite the long history of Feral Cats Felis catus in Hawai'i, there has been little research to provide strategies to improve control programmes and reduce depredation on endangered species. Our objective Was to develop a predictive model to determine how landscape features on Mauna Kea, such as habitat, elevation, and proximity to roads, may affect the number of Feral Cats captured at each trap. We used log-link generalized linear models and QAIC c model ranking criteria to determine the effect of these factors. We found that The number of cats captured per trap Was related to effort, habitat type, and Whether traps Were located on The West or North Slope of Mauna Kea. We recommend an adaptive management strategy to minimize trapping interference by non-target Small Indian Mongoose Herpestes auropunctatus with toxicants, to focus trapping efforts in M??mane Sophora chrysophylla habitat on the West slope of Mauna Kea, and to cluster traps near others that have previously captured multiple cats.

  16. [Strategies and mechanisms of soil springtails in adapting lower temperature environment: research progress].

    PubMed

    Liu, Jing; Wang, Yun-Biao; Wu, Dong-Hui

    2012-12-01

    Low temperature and drought are the main environmental factors threatening the animals living in arctic area and cold temperate regions. To adapt the severe environment, the animals should adopt appropriate strategies. As a group of arthopods with freeze-avoiding strategy, soil springtails have the similar ecological mechanisms and modes of cold resistance/tolerance as insects, manifesting in the cold acclimation and drought tolerance to decrease the damage of ice crystal formation. During cold acclimation, there are a rapid increase of glycerol, a rapid decrease of fucose and glucose, and the production of anti-freeze proteins (AFP) , and exists the inter-transformation of different kinds of lipids to improve the flow of cell membrane to protect the cell from low temperature injury. In addition, soil springtails have their own specific modes and mechanisms to tolerate low temperature stress, mainly the vertical migration under the protection of snow cover and the excretion of ice nucleator from haemolymph, illustrating that it's of significance to research the cryobiology of soil springtails. This paper summarized the modes and mechanisms of soil springtails in tolerating low temperature environment, reviewed the research progress on the eco-physiology of the springtails, discussed the existing problems of the researches on the low temperature tolerance of the springtails, and prospected the research directions of the springtails low temperature ecology under the background of global change.

  17. Land use and management change under climate change adaptation and mitigation strategies: a U.S. case study

    USGS Publications Warehouse

    Mu, Jianhong E.; Wein, Anne; McCarl, Bruce

    2015-01-01

    We examine the effects of crop management adaptation and climate mitigation strategies on land use and land management, plus on related environmental and economic outcomes. We find that crop management adaptation (e.g. crop mix, new species) increases Greenhouse gas (GHG) emissions by 1.7 % under a more severe climate projection while a carbon price reduces total forest and agriculture GHG annual flux by 15 % and 9 %, respectively. This shows that trade-offs are likely between mitigation and adaptation. Climate change coupled with crop management adaptation has small and mostly negative effects on welfare; mitigation, which is implemented as a carbon price starting at $15 per metric ton carbon dioxide (CO2) equivalent with a 5 % annual increase rate, bolsters welfare carbon payments. When both crop management adaptation and carbon price are implemented the effects of the latter dominates.

  18. Development of a viewing strategy during adaptation to an artificial central scotoma.

    PubMed

    Varsori, Michael; Perez-Fornos, Angelica; Safran, Avinoam B; Whatham, Andrew R

    2004-10-01

    without guided training; (2) two distinctly separate retinal areas can be used in an integrated manner during reading; (4) stimulus position in visual space can influence viewing strategy; (5) in general, reading encourages a preference for the inferior over the superior visual field, but not the left over right visual field. Letter/word/text recognition and reading speeds increased progressively across sessions, even after scotoma lateralisation appeared stabilised suggesting that multiple mechanism are involved in adaptive changes.

  19. Adapt

    NASA Astrophysics Data System (ADS)

    Bargatze, L. F.

    2015-12-01

    Active Data Archive Product Tracking (ADAPT) is a collection of software routines that permits one to generate XML metadata files to describe and register data products in support of the NASA Heliophysics Virtual Observatory VxO effort. ADAPT is also a philosophy. The ADAPT concept is to use any and all available metadata associated with scientific data to produce XML metadata descriptions in a consistent, uniform, and organized fashion to provide blanket access to the full complement of data stored on a targeted data server. In this poster, we present an application of ADAPT to describe all of the data products that are stored by using the Common Data File (CDF) format served out by the CDAWEB and SPDF data servers hosted at the NASA Goddard Space Flight Center. These data servers are the primary repositories for NASA Heliophysics data. For this purpose, the ADAPT routines have been used to generate data resource descriptions by using an XML schema named Space Physics Archive, Search, and Extract (SPASE). SPASE is the designated standard for documenting Heliophysics data products, as adopted by the Heliophysics Data and Model Consortium. The set of SPASE XML resource descriptions produced by ADAPT includes high-level descriptions of numerical data products, display data products, or catalogs and also includes low-level "Granule" descriptions. A SPASE Granule is effectively a universal access metadata resource; a Granule associates an individual data file (e.g. a CDF file) with a "parent" high-level data resource description, assigns a resource identifier to the file, and lists the corresponding assess URL(s). The CDAWEB and SPDF file systems were queried to provide the input required by the ADAPT software to create an initial set of SPASE metadata resource descriptions. Then, the CDAWEB and SPDF data repositories were queried subsequently on a nightly basis and the CDF file lists were checked for any changes such as the occurrence of new, modified, or deleted

  20. Symmetry-adapted perturbation-theory calculations of intermolecular forces employing density-functional description of monomers.

    PubMed

    Misquitta, Alston J; Szalewicz, Krzysztof

    2005-06-01

    A symmetry-adapted perturbation theory based on Kohn-Sham determinants [SAPT(KS)] and utilizing asymptotically corrected exchange-correlation potentials has been applied to the He2, Ne2, (H2O)2, and (CO2)2 dimers. It is shown that SAPT(KS) is able to recover the electrostatic, first-order exchange, second-order induction, and exchange-induction energies with an accuracy approaching and occasionally surpassing that of regular SAPT at the currently programmed theory level. The use of the asymptotic corrections is critical to achieve this accuracy. The SAPT(KS) results can be obtained at a small fraction of the time needed for regular SAPT calculations. The robustness of the SAPT(KS) method with respect to the basis set size is also demonstrated. A theoretical justification for high accuracy of SAPT(KS) predictions for the electrostatic, first-order exchange, and second-order induction energies has been provided.

  1. Analysis prediction of Indonesian banks (BCA, BNI, MANDIRI) using adaptive neuro-fuzzy inference system (ANFIS) and investment strategies

    NASA Astrophysics Data System (ADS)

    Trianto, Andriantama Budi; Hadi, I. M.; Liong, The Houw; Purqon, Acep

    2015-09-01

    Indonesian economical development is growing well. It has effect for their invesment in Banks and the stock market. In this study, we perform prediction for the three blue chips of Indonesian bank i.e. BCA, BNI, and MANDIRI by using the method of Adaptive Neuro-Fuzzy Inference System (ANFIS) with Takagi-Sugeno rules and Generalized bell (Gbell) as the membership function. Our results show that ANFIS perform good prediction with RMSE for BCA of 27, BNI of 5.29, and MANDIRI of 13.41, respectively. Furthermore, we develop an active strategy to gain more benefit. We compare between passive strategy versus active strategy. Our results shows that for the passive strategy gains 13 million rupiah, while for the active strategy gains 47 million rupiah in one year. The active investment strategy significantly shows gaining multiple benefit than the passive one.

  2. Identification of Vocational Education Counseling Strategies Needed at the Secondary Level for Students to Succeed in Vocational Education and Become Employable. Final Data Summary.

    ERIC Educational Resources Information Center

    Feller, Rich

    This study was conducted to determine what vocational counseling strategies are used with students who enroll in vocational education programs, their effectiveness, and their perceptions of helpfulness by graduates and employers. Different surveys were developed and sent to the following groups in Colorado: 60 high school counselors, 60…

  3. Adaptation strategies for health impacts of climate change in Western Australia: Application of a Health Impact Assessment framework

    SciTech Connect

    Spickett, Jeffery T.; Brown, Helen L.; Katscherian, Dianne

    2011-04-15

    Climate change is one of the greatest challenges facing the globe and there is substantial evidence that this will result in a number of health impacts, regardless of the level of greenhouse gas mitigation. It is therefore apparent that a combined approach of mitigation and adaptation will be required to protect public health. While the importance of mitigation is recognised, this project focused on the role of adaptation strategies in addressing the potential health impacts of climate change. The nature and magnitude of these health impacts will be determined by a number of parameters that are dependent upon the location. Firstly, climate change will vary between regions. Secondly, the characteristics of each region in terms of population and the ability to adapt to changes will greatly influence the extent of the health impacts that are experienced now and into the future. Effective adaptation measures therefore need to be developed with these differences in mind. A Health Impact Assessment (HIA) framework was used to consider the implications of climate change on the health of the population of Western Australia (WA) and to develop a range of adaptive responses suited to WA. A broad range of stakeholders participated in the HIA process, providing informed input into developing an understanding of the potential health impacts and potential adaptation strategies from a diverse sector perspective. Potential health impacts were identified in relation to climate change predictions in WA in the year 2030. The risk associated with each of these impacts was assessed using a qualitative process that considered the consequences and the likelihood of the health impact occurring. Adaptations were then developed which could be used to mitigate the identified health impacts and provide responses which could be used by Government for future decision making. The periodic application of a HIA framework is seen as an ideal tool to develop appropriate adaptation strategies to

  4. Speech recognition in reverberant and noisy environments employing multiple feature extractors and i-vector speaker adaptation

    NASA Astrophysics Data System (ADS)

    Alam, Md Jahangir; Gupta, Vishwa; Kenny, Patrick; Dumouchel, Pierre

    2015-12-01

    The REVERB challenge provides a common framework for the evaluation of feature extraction techniques in the presence of both reverberation and additive background noise. State-of-the-art speech recognition systems perform well in controlled environments, but their performance degrades in realistic acoustical conditions, especially in real as well as simulated reverberant environments. In this contribution, we utilize multiple feature extractors including the conventional mel-filterbank, multi-taper spectrum estimation-based mel-filterbank, robust mel and compressive gammachirp filterbank, iterative deconvolution-based dereverberated mel-filterbank, and maximum likelihood inverse filtering-based dereverberated mel-frequency cepstral coefficient features for speech recognition with multi-condition training data. In order to improve speech recognition performance, we combine their results using ROVER (Recognizer Output Voting Error Reduction). For two- and eight-channel tasks, to get benefited from the multi-channel data, we also use ROVER, instead of the multi-microphone signal processing method, to reduce word error rate by selecting the best scoring word at each channel. As in a previous work, we also apply i-vector-based speaker adaptation which was found effective. In speech recognition task, speaker adaptation tries to reduce mismatch between the training and test speakers. Speech recognition experiments are conducted on the REVERB challenge 2014 corpora using the Kaldi recognizer. In our experiments, we use both utterance-based batch processing and full batch processing. In the single-channel task, full batch processing reduced word error rate (WER) from 10.0 to 9.3 % on SimData as compared to utterance-based batch processing. Using full batch processing, we obtained an average WER of 9.0 and 23.4 % on the SimData and RealData, respectively, for the two-channel task, whereas for the eight-channel task on the SimData and RealData, the average WERs found were 8

  5. Chemotactic signal transduction and phosphate metabolism as adaptive strategies during citrus canker induction by Xanthomonas citri.

    PubMed

    Moreira, Leandro Marcio; Facincani, Agda Paula; Ferreira, Cristiano Barbalho; Ferreira, Rafael Marine; Ferro, Maria Inês Tiraboshi; Gozzo, Fabio Cesar; de Oliveira, Julio Cezar Franco; Ferro, Jesus Aparecido; Soares, Márcia Regina

    2015-03-01

    The genome of Xanthomonas citri subsp. Citri strain 306 pathotype A (Xac) was completely sequenced more than 10 years; to date, few studies involving functional genomics Xac and its host compatible have been developed, specially related to adaptive events that allow the survival of Xac within the plant. Proteomic analysis of Xac showed that the processes of chemotactic signal transduction and phosphate metabolism are key adaptive strategies during the interaction of a pathogenic bacterium with its plant host. The results also indicate the importance of a group of proteins that may not be directly related to the classical virulence factors, but that are likely fundamental to the success of the initial stages of the infection, such as methyl-accepting chemotaxis protein (Mcp) and phosphate specific transport (Pst). Furthermore, the analysis of the mutant of the gene pstB which codifies to an ABC phosphate transporter subunit revealed a complete absence of citrus canker symptoms when inoculated in compatible hosts. We also conducted an in silico analysis which established the possible network of genes regulated by two-component systems PhoPQ and PhoBR (related to phosphate metabolism), and possible transcriptional factor binding site (TFBS) motifs of regulatory proteins PhoB and PhoP, detaching high degree of conservation of PhoB TFBS in 84 genes of Xac genome. This is the first time that chemotaxis signal transduction and phosphate metabolism were therefore indicated to be fundamental to the process of colonization of plant tissue during the induction of disease associated with Xanthomonas genus bacteria.

  6. Ecological fitness and strategies of adaptation of Bartonella species to their hosts and vectors☆

    PubMed Central

    Chomel, Bruno B.; Boulouis, Henri-Jean; Breitschwerdt, Edward B.; Kasten, Rickie W.; Vayssier-Taussat, Muriel; Birtles, Richard J.; Koehler, Jane E.; Dehio, Christoph

    2009-01-01

    Bartonella spp. are facultative intracellular bacteria that cause characteristic host-restricted hemotropic infections in mammals and are typically transmitted by blood-sucking arthropods. In the mammalian reservoir, these bacteria initially infect a yet unrecognized primary niche, which seeds organisms into the blood stream leading to the establishment of a long-lasting intra-erythrocytic bacteremia as the hall-mark of infection. Bacterial type IV secretion systems, which are supra-molecular transporters ancestrally related to bacterial conjugation systems, represent crucial pathogenicity factors that have contributed to a radial expansion of the Bartonella lineage in nature by facilitating adaptation to unique mammalian hosts. On the molecular level, the type IV secretion system VirB/VirD4 is known to translocate a cocktail of different effector proteins into host cells, which subvert multiple cellular functions to the benefit of the infecting pathogen. Furthermore, bacterial adhesins mediate a critical, early step in the pathogenesis of the bartonellae by binding to extracellular matrix components of host cells, which leads to firm bacterial adhesion to the cell surface as a prerequisite for the efficient translocation of type IV secretion effector proteins. The best-studied adhesins in bartonellae are the orthologous trimeric autotransporter adhesins, BadA in Bartonella henselae and the Vomp family in Bartonella quintana. Genetic diversity and strain variability also appear to enhance the ability of bartonellae to invade not only specific reservoir hosts, but also accidental hosts, as shown for B. henselae. Bartonellae have been identified in many different blood-sucking arthropods, in which they are typically found to cause extracellular infections of the mid-gut epithelium. Adaptation to specific vectors and reservoirs seems to be a common strategy of bartonellae for transmission and host diversity. However, knowledge regarding arthropod specificity

  7. Graded-threshold parametric response maps: towards a strategy for adaptive dose painting

    NASA Astrophysics Data System (ADS)

    Lausch, A.; Jensen, N.; Chen, J.; Lee, T. Y.; Lock, M.; Wong, E.

    2014-03-01

    Purpose: To modify the single-threshold parametric response map (ST-PRM) method for predicting treatment outcomes in order to facilitate its use for guidance of adaptive dose painting in intensity-modulated radiotherapy. Methods: Multiple graded thresholds were used to extend the ST-PRM method (Nat. Med. 2009;15(5):572-576) such that the full functional change distribution within tumours could be represented with respect to multiple confidence interval estimates for functional changes in similar healthy tissue. The ST-PRM and graded-threshold PRM (GT-PRM) methods were applied to functional imaging scans of 5 patients treated for hepatocellular carcinoma. Pre and post-radiotherapy arterial blood flow maps (ABF) were generated from CT-perfusion scans of each patient. ABF maps were rigidly registered based on aligning tumour centres of mass. ST-PRM and GT-PRM analyses were then performed on overlapping tumour regions within the registered ABF maps. Main findings: The ST-PRMs contained many disconnected clusters of voxels classified as having a significant change in function. While this may be useful to predict treatment response, it may pose challenges for identifying boost volumes or for informing dose-painting by numbers strategies. The GT-PRMs included all of the same information as ST-PRMs but also visualized the full tumour functional change distribution. Heterogeneous clusters in the ST-PRMs often became more connected in the GT-PRMs by voxels with similar functional changes. Conclusions: GT-PRMs provided additional information which helped to visualize relationships between significant functional changes identified by ST-PRMs. This may enhance ST-PRM utility for guiding adaptive dose painting.

  8. Variable-Length Computerized Adaptive Testing: Adaptation of the A-Stratified Strategy in Item Selection with Content Balancing

    ERIC Educational Resources Information Center

    Huo, Yan

    2009-01-01

    Variable-length computerized adaptive testing (CAT) can provide examinees with tailored test lengths. With the fixed standard error of measurement ("SEM") termination rule, variable-length CAT can achieve predetermined measurement precision by using relatively shorter tests compared to fixed-length CAT. To explore the application of…

  9. Exploring the Interplay of Adaptive and Maladaptive Strategies: Prevalence and Functionality of Anger Regulation Profiles in Early Adolescence

    ERIC Educational Resources Information Center

    Otterpohl, Nantje; Schwinger, Malte; Wild, Elke

    2016-01-01

    In emotion regulation research, it is common to distinguish adaptive from maladaptive emotion regulation strategies. However, little is known about their interactional impact (compensational or interfering effects) on adolescents' adjustment. We collected longitudinal, multiple informant questionnaire data from N = 608 adolescents and their…

  10. Understanding the Acculturation Experience of Chinese Adolescent Students: Sociocultural Adaptation Strategies and a Positive Bicultural and Bilingual Identity

    ERIC Educational Resources Information Center

    Tong, Virginia M.

    2014-01-01

    The acculturation of Chinese immigrant high school students was examined as it relates to students' level of interaction with teachers and peers and participation in American school activities. Findings from a regression analysis revealed five variables (sociocultural adaptation strategies) that facilitate students' adjustment process:…

  11. Expanding Acculturation Theory: Are Acculturation Models and the Adaptiveness of Acculturation Strategies Generalizable in a Colonial Context?

    ERIC Educational Resources Information Center

    Cheung-Blunden, Violet L.; Juang, Linda P.

    2008-01-01

    Most acculturation research has been conducted in immigrant settings. The present study examined the generalizability of acculturation models and the adaptiveness of acculturation strategies in another bicultural environment--a colonial setting. The sample included 138 girls (M = 13.8 years) and their parents from Hong Kong, a former British…

  12. Impact of climate change and adaptation strategies on crop production in Nigeria

    NASA Astrophysics Data System (ADS)

    Mereu, V.; Gallo, A.; Carboni, G.; Spano, D.

    2012-04-01

    The vulnerability of agricultural to climate change is of particular interest to policy makers because the high social and economical importance of agriculture sector in Nigeria, which contributes approximately 40 percent to total GDP and support 70 percent of the population. It is necessary to investigate the potential climate change impacts in order to identify specific agricultural sectors and Agro-Ecological Zones that will be more vulnerable to changes in climatic conditions and implement and develop the most appropriate policies to cope with these changes. In this framework, this study aimed to assess the climate change impacts on Nigerian agricultural sector and to explore some of potential adaptation strategies for the most important crops in the food basket of the Country. The analysis was made using the DSSAT-CSM (Decision Support System for Agrotechnology Transfer - Cropping System Model) software, version 4.5. Crop simulation models included in DSSAT are tools that allows to simulate physiological process of crop growth, development and production, by combining genetic crop characteristics and environmental (soil and weather) conditions. In this analysis, for each selected crop, the models included into DSSAT-CSM software were ran, after a calibration phase, to evaluate climate change impacts on crop production. The climate data used for the analysis are derived by the Regional Circulation Model COSMO-CLM, from 1971 to 2065, at 8 km of spatial resolution. The RCM model output were "perturbed" with 10 Global Climate Models in order to have a wide variety of possible climate projections for impact analysis. Multiple combinations of soils and climate conditions, crop management and varieties were considered for each Agro-Ecological Zone of Nigeria. The climate impact assessment was made by comparing the yield obtained with the climate data for the present period and the yield obtainable under future changed climate conditions. The models ran by keeping

  13. Climate Change Potential Impacts on the Built Environment and Possible Adaptation Strategies

    NASA Technical Reports Server (NTRS)

    Quattrochi, Dale A.

    2014-01-01

    The built environment consists of components that exist at a range of scales from small (e.g., houses, shopping malls) to large (e.g., transportation networks) to highly modified landscapes such as cities. Thus, the impacts of climate change on the built environment may have a multitude of effects on humans and the land. The impact of climate change may be exacerbated by the interaction of different events that singly may be minor, but together may have a synergistic set of impacts that are significant. Also, mechanisms may exist wherein the built environment, particularly in the form of cities, may affect weather and the climate on local and regional scales. Hence, a city may be able to cope with prolonged heat waves, but if this is combined with severe drought, the overall result could be significant or even catastrophic, as accelerating demand for energy to cooling taxes water supplies needed both for energy supply and municipal water needs. This presentation surveys potential climate change impacts on the built environment from the perspective of the National Climate Assessment, and explores adaptation measures that can be employed to mitigate these impacts.

  14. Using AQUACROP to model the impacts of future climates on crop production and possible adaptation strategies in Sardinia and Tunisia

    NASA Astrophysics Data System (ADS)

    Bird, Neil; Benabdallah, Sihem; Gouda, Nadine; Hummel, Franz; La Jeunesse, Isabelle; Meyer, Swen; Soddu, Antonino; Woess-Gallasch, Susanne

    2014-05-01

    A work package in the FP-7 funded CLIMB Project - Climate Induced Changes on the Hydrology of Mediterranean Basins Reducing Uncertainty and Quantifying Risk through an Integrated Monitoring and Modeling System had the goal of assessing socioeconomic vulnerability in two super-sites in future climates (2040-2070). The work package had deliverables to describe of agricultural adaptation measures appropriate to each site under future water availability scenarios and assess the risk of income losses due to water shortages in agriculture. The FAO model AQUACROP was used to estimate losses of agricultural productivity and indicate possible adaptation strategies. The presentation will focus on two interesting crops which show extreme vulnerability to expected changes in climate; irrigated lettuce in Sardinia and irrigated tomatoes in Tunisia. Modelling methodology, results and possible adaptation strategies will be presented.

  15. Improving Education and Employment for Disadvantaged Young Men: Proven and Promising Strategies. Discussion Paper No. 1374-10

    ERIC Educational Resources Information Center

    Heinrich, Carolyn J.; Holzer, Harry J.

    2010-01-01

    Low high school graduation rates and sharply declining employment rates among disadvantaged youth have led to increasing numbers of youth who are disconnected from both school and work. What programs and policies might prevent these disconnections and improve educational and employment outcomes, particularly among young men? We review the evidence…

  16. Combined use of leaf size and economics traits allows direct comparison of hydrophyte and terrestrial herbaceous adaptive strategies

    PubMed Central

    Pierce, Simon; Brusa, Guido; Sartori, Matteo; Cerabolini, Bruno E. L.

    2012-01-01

    Background and Aims Hydrophytes generally exhibit highly acquisitive leaf economics. However, a range of growth forms is evident, from small, free-floating and rapidly growing Lemniden to large, broad-leaved Nymphaeiden, denoting variability in adaptive strategies. Traits used to classify adaptive strategies in terrestrial species, such as canopy height, are not applicable to hydrophytes. We hypothesize that hydrophyte leaf size traits and economics exhibit sufficient overlap with terrestrial species to allow a common classification of plant functional types, sensu Grime's CSR theory. Methods Leaf morpho-functional traits were measured for 61 species from 47 water bodies in lowland continental, sub-alpine and alpine bioclimatic zones in southern Europe and compared against the full leaf economics spectrum and leaf size range of terrestrial herbs, and between hydrophyte growth forms. Key Results Hydrophytes differed in the ranges and mean values of traits compared with herbs, but principal components analysis (PCA) demonstrated that both groups shared axes of trait variability: PCA1 encompassed size variation (area and mass), and PCA2 ranged from relatively dense, carbon-rich leaves to nitrogen-rich leaves of high specific leaf area (SLA). Most growth forms exhibited trait syndromes directly equivalent to herbs classified as R adapted, although Nymphaeiden ranged between C and SR adaptation. Conclusions Our findings support the hypothesis that hydrophyte adaptive strategy variation reflects fundamental trade-offs in economics and size that govern all plants, and that hydrophyte adaptive strategies can be directly compared with terrestrial species by combining leaf economics and size traits. PMID:22337079

  17. Evolution of the fruit endocarp: molecular mechanisms underlying adaptations in seed protection and dispersal strategies

    PubMed Central

    Dardick, Chris; Callahan, Ann M.

    2014-01-01

    Plant evolution is largely driven by adaptations in seed protection and dispersal strategies that allow diversification into new niches. This is evident by the tremendous variation in flowering and fruiting structures present both across and within different plant lineages. Within a single plant family a staggering variety of fruit types can be found such as fleshy fruits including berries, pomes, and drupes and dry fruit structures like achenes, capsules, and follicles. What are the evolutionary mechanisms that enable such dramatic shifts to occur in a relatively short period of time? This remains a fundamental question of plant biology today. On the surface it seems that these extreme differences in form and function must be the consequence of very different developmental programs that require unique sets of genes. Yet as we begin to decipher the molecular and genetic basis underlying fruit form it is becoming apparent that simple genetic changes in key developmental regulatory genes can have profound anatomical effects. In this review, we discuss recent advances in understanding the molecular mechanisms of fruit endocarp tissue differentiation that have contributed to species diversification within three plant lineages. PMID:25009543

  18. Pseudomonas aeruginosa adapts its iron uptake strategies in function of the type of infections.

    PubMed

    Cornelis, Pierre; Dingemans, Jozef

    2013-01-01

    Pseudomonas aeruginosa is a Gram-negative γ-Proteobacterium which is known for its capacity to colonize various niches, including some invertebrate and vertebrate hosts, making it one of the most frequent bacteria causing opportunistic infections. P. aeruginosa is able to cause acute as well as chronic infections and it uses different colonization and virulence factors to do so. Infections range from septicemia, urinary infections, burn wound colonization, and chronic colonization of the lungs of cystic fibrosis patients. Like the vast majority of organisms, P. aeruginosa needs iron to sustain growth. P. aeruginosa utilizes different strategies to take up iron, depending on the type of infection it causes. Two siderophores are produced by this bacterium, pyoverdine and pyochelin, characterized by high and low affinities for iron respectively. P. aeruginosa is also able to utilize different siderophores from other microorganisms (siderophore piracy). It can also take up heme from hemoproteins via two different systems. Under microaerobic or anaerobic conditions, P. aeruginosa is also able to take up ferrous iron via its Feo system using redox-cycling phenazines. Depending on the type of infection, P. aeruginosa can therefore adapt by switching from one iron uptake system to another as we will describe in this short review.

  19. Design and analysis of self-adapted task scheduling strategies in wireless sensor networks.

    PubMed

    Guo, Wenzhong; Xiong, Naixue; Chao, Han-Chieh; Hussain, Sajid; Chen, Guolong

    2011-01-01

    In a wireless sensor network (WSN), the usage of resources is usually highly related to the execution of tasks which consume a certain amount of computing and communication bandwidth. Parallel processing among sensors is a promising solution to provide the demanded computation capacity in WSNs. Task allocation and scheduling is a typical problem in the area of high performance computing. Although task allocation and scheduling in wired processor networks has been well studied in the past, their counterparts for WSNs remain largely unexplored. Existing traditional high performance computing solutions cannot be directly implemented in WSNs due to the limitations of WSNs such as limited resource availability and the shared communication medium. In this paper, a self-adapted task scheduling strategy for WSNs is presented. First, a multi-agent-based architecture for WSNs is proposed and a mathematical model of dynamic alliance is constructed for the task allocation problem. Then an effective discrete particle swarm optimization (PSO) algorithm for the dynamic alliance (DPSO-DA) with a well-designed particle position code and fitness function is proposed. A mutation operator which can effectively improve the algorithm's ability of global search and population diversity is also introduced in this algorithm. Finally, the simulation results show that the proposed solution can achieve significant better performance than other algorithms.

  20. Real-Time Wastewater System Operational Strategy Adaptation for Rainfall Variability

    NASA Astrophysics Data System (ADS)

    Zimmer, A. L.; Minsker, B. S.; Schmidt, A.; Ostfeld, A.; Treinish, L. A.

    2010-12-01

    Management strategies for many large-scale wastewater systems are based on longstanding rules and may not effectively utilize system capacity for every storm event. Conservative operational rules are established to prevent flow instabilities. However, the rules may be modified to retain more wastewater and reduce overflows while continuing to avoid hydraulic conditions that lead to transients. Possible adaptation of system decision rules can be evaluated through coupling radar rainfall, a hydrologic system model, and an optimization routine. In this study, genetic algorithm optimization is evaluated for a hydrologic test case modeled after the Chicago Tunnel and Reservoir Plan (TARP) that minimizes combined sewer overflow (CSO) discharge to nearby waterways. This approach identifies potential new operational rules that reliably utilize deep tunnel storage and reduce overflows for a variety of historic storm events. The study utilizes a model based on the portion of the TARP deep tunnel system that flows directly under the North Branch of the Chicago River. Potential overflows coming from the upstream pipe and interceptor system are directed into the deep tunnel through sluice gates. System decision variables consist of sluice gate positions that control whether water enters the deep tunnel or flows into the river, as well as a treatment plant pumping rate on the interceptor lines. For different optimization runs, modifications are made to existing hydraulic structures to evaluate solution robustness for comparable hydraulic systems. The operational objective is to minimize the total volume of overflows for each storm event through a decision sequence, generated at discretized intervals, within a model predictive control (MPC) framework. Current operational strategies restrict water entry to the deep tunnel when an averaged tunnel water level reaches 70 percent of the diameter to avoid hydraulic transients. The optimization routine implements constraints that

  1. Assessment of impact of climate change and adaptation strategies on maize production in Uganda

    NASA Astrophysics Data System (ADS)

    Kikoyo, Duncan A.; Nobert, Joel

    2016-06-01

    Globally, various climatic studies have estimated a reduction of crop yields due to changes in surface temperature and precipitation especially for the developing countries which is heavily dependent on agriculture and lacks resources to counter the negative effects of climate change. Uganda's economy and the wellbeing of its populace depend on rain-fed agriculture which is susceptible to climate change. This study quantified the impacts of climate change and variability in Uganda and how coping strategies can enhance crop production against climate change and/or variability. The study used statistical methods to establish various climate change and variability indicators across the country, and uses the FAO AquaCrop model to simulate yields under possible future climate scenarios with and without adaptation strategies. Maize, the most widely grown crop was used for the study. Meteorological, soil and crop data were collected for various districts representing the maize growing ecological zones in the country. Based on this study, it was found that temperatures have increased by up to 1 °C across much of Uganda since the 1970s, with rates of warming around 0.3 °C per decade across the country. High altitude, low rainfall regions experience the highest level of warming, with over 0.5 °C/decade recorded in Kasese. Rainfall is variable and does not follow a specific significant increasing or decreasing trend. For both future climate scenarios, Maize yields will reduce in excess of 4.7% for the fast warming-low rainfall climates but increase on average by 3.5% for slow warming-high rainfall regions, by 2050. Improved soil fertility can improve yields by over 50% while mulching and use of surface water management practices improve yields by single digit percentages. The use of fertilizer application needs to go hand in hand with other water management strategies since more yields as a result of the improved soil fertility leads to increased water stress, especially

  2. Private adaptation strategies and implementation in flood risk management: why people do nothing?

    NASA Astrophysics Data System (ADS)

    Karagiorgos, Konstantinos; Thaler, Thomas; Maris, Fotios; Paparrizos, Spyros; Fuchs, Sven

    2015-04-01

    In the past decades, vulnerability assessment has emerged as an important field of research in flood risk management, in particular with respect to climate change and necessary adaptation strategies for the society. Probably starting with Chamber's seminal article on vulnerability, coping and policy (Chambers 1989), and further developed as the causal structure of vulnerability by Bohle (2001) and others, at least two research paradigms exist: an internal side focusing on societal resilience and coping capacities, and an external side targeted at a reduction of negative effects in terms of loss reduction (Fuchs 2009). Despite considerable research effects, however, different definitions and concepts still dominate the debate; it is surely that different scientific disciplines are working with this term: natural scientists, engineers, social scientists or economists, to name just a few. Each discipline defines vulnerability in a way which fits to their disciplinary purposes (Fuchs et al. 2011). But why has there been so little progress in our ability to adapt to flood hazards? White et al. (2001) summarised this paradox in an article with the title "Knowing better and losing even more - the use of knowledge in hazard management". One of the fundamental reasons for the lack of progress is the continuing separation of research on natural processes and socio-economic processes without considering interaction between these systems (Fuchs & Keiler 2013), as well as between scientific research results and the policy implementation (Medd & Marvin 2005). Moreover, as many studies were focused on the vulnerability of least developed societies to natural hazards (O'Brien et al. 2008), there is a particular lack in studies targeted at an implementation of existing adaptation frameworks at the level of highly-developed countries (Field et al. 2012; Scolobig et al. 2012). This gap results in a challenge for attempts to develop formal models into practical application and policy

  3. Comparison of Item Targeting Strategies for Pass/Fail Computer Adaptive Tests.

    ERIC Educational Resources Information Center

    Bergstrom, Betty A.; Gershon, Richard

    The most useful method of item selection for making pass-fail decisions with a Computerized Adaptive Test (CAT) was studied. Medical technology students (n=86) took a computer adaptive test in which items were targeted to the ability of the examinee. The adaptive algorithm that selected items and estimated person measures used the Rasch model and…

  4. Robustness and strategies of adaptation among farmer varieties of African Rice (Oryza glaberrima) and Asian Rice (Oryza sativa) across West Africa.

    PubMed

    Mokuwa, Alfred; Nuijten, Edwin; Okry, Florent; Teeken, Béla; Maat, Harro; Richards, Paul; Struik, Paul C

    2013-01-01

    This study offers evidence of the robustness of farmer rice varieties (Oryza glaberrima and O. sativa) in West Africa. Our experiments in five West African countries showed that farmer varieties were tolerant of sub-optimal conditions, but employed a range of strategies to cope with stress. Varieties belonging to the species Oryza glaberrima - solely the product of farmer agency - were the most successful in adapting to a range of adverse conditions. Some of the farmer selections from within the indica and japonica subspecies of O. sativa also performed well in a range of conditions, but other farmer selections from within these two subspecies were mainly limited to more specific niches. The results contradict the rather common belief that farmer varieties are only of local value. Farmer varieties should be considered by breeding programmes and used (alongside improved varieties) in dissemination projects for rural food security.

  5. Adaptive marker-free registration using a multiple point strategy for real-time and robust endoscope electromagnetic navigation.

    PubMed

    Luo, Xiongbiao; Wan, Ying; He, Xiangjian; Mori, Kensaku

    2015-02-01

    Registration of pre-clinical images to physical space is indispensable for computer-assisted endoscopic interventions in operating rooms. Electromagnetically navigated endoscopic interventions are increasingly performed at current diagnoses and treatments. Such interventions use an electromagnetic tracker with a miniature sensor that is usually attached at an endoscope distal tip to real time track endoscope movements in a pre-clinical image space. Spatial alignment between the electromagnetic tracker (or sensor) and pre-clinical images must be performed to navigate the endoscope to target regions. This paper proposes an adaptive marker-free registration method that uses a multiple point selection strategy. This method seeks to address an assumption that the endoscope is operated along the centerline of an intraluminal organ which is easily violated during interventions. We introduce an adaptive strategy that generates multiple points in terms of sensor measurements and endoscope tip center calibration. From these generated points, we adaptively choose the optimal point, which is the closest to its assigned the centerline of the hollow organ, to perform registration. The experimental results demonstrate that our proposed adaptive strategy significantly reduced the target registration error from 5.32 to 2.59 mm in static phantoms validation, as well as from at least 7.58 mm to 4.71 mm in dynamic phantom validation compared to current available methods.

  6. Regional and Household Adaptation Strategies to Climate Extremes: the Case Study of the Beava River Basin, the Czech Republic

    NASA Astrophysics Data System (ADS)

    Duží, Barbora; Stojanov, Robert; Vikhrov, Dmytro

    2013-04-01

    We investigate regional and household adaptation strategies in the region affected by climate extremes, focusing on floods occurrence during past 15 years period. The main research question is: What is the overall state of adaptation measurements to climate extremes on the Bečva river basin? Target area is located along upper and middle part of the Bečva river basin in the east of the Czech Republic. The main theoretical concepts draw from differentiations between coping/adaptation strategies to climate extremes and theory of focusing event as a starter of changes in attention and agenda of problem solution. We apply mixed empirical research and case study approach. First we use qualitative research to serve as an initial entrance to the issue, to find out the perception of adaptation progress and preparedness to climate extremes on regional level. We conducted deep interviews (N=20) with relevant stakeholders. We proceed with quantitative research through the conducting face-to face questionnaires with household residents (N=305) in no, low and no risk area in relation to flood occurrence. We designed set of questions to find out relation among experiences with flood, the level of damages and applied emergency and adaptation measurements.

  7. Adaptation strategies of endolithic chlorophototrophs to survive the hyperarid and extreme solar radiation environment of the Atacama Desert

    PubMed Central

    Wierzchos, Jacek; DiRuggiero, Jocelyne; Vítek, Petr; Artieda, Octavio; Souza-Egipsy, Virginia; Škaloud, Pavel; Tisza, Michel; Davila, Alfonso F.; Vílchez, Carlos; Garbayo, Inés; Ascaso, Carmen

    2015-01-01

    The Atacama Desert, northern Chile, is one of the driest deserts on Earth and, as such, a natural laboratory to explore the limits of life and the strategies evolved by microorganisms to adapt to extreme environments. Here we report the exceptional adaptation strategies of chlorophototrophic and eukaryotic algae, and chlorophototrophic and prokaryotic cyanobacteria to the hyperarid and extremely high solar radiation conditions occurring in this desert. Our approach combined several microscopy techniques, spectroscopic analytical methods, and molecular analyses. We found that the major adaptation strategy was to avoid the extreme environmental conditions by colonizing cryptoendolithic, as well as, hypoendolithic habitats within gypsum deposits. The cryptoendolithic colonization occurred a few millimeters beneath the gypsum surface and showed a succession of organized horizons of algae and cyanobacteria, which has never been reported for endolithic microbial communities. The presence of cyanobacteria beneath the algal layer, in close contact with sepiolite inclusions, and their hypoendolithic colonization suggest that occasional liquid water might persist within these sub-microhabitats. We also identified the presence of abundant carotenoids in the upper cryptoendolithic algal habitat and scytonemin in the cyanobacteria hypoendolithic habitat. This study illustrates that successful lithobiontic microbial colonization at the limit for microbial life is the result of a combination of adaptive strategies to avoid excess solar irradiance and extreme evapotranspiration rates, taking advantage of the complex structural and mineralogical characteristics of gypsum deposits—conceptually called “rock's habitable architecture.” Additionally, self-protection by synthesis and accumulation of secondary metabolites likely produces a shielding effect that prevents photoinhibition and lethal photooxidative damage to the chlorophototrophs, representing another level of

  8. Climate Change Adaptation and Climate Related Disaster Risk Reduction Strategies in Zimbabwe and Malawi

    NASA Astrophysics Data System (ADS)

    Mubaya, C. P.; Ngepah, N.; Seyama, W.

    2015-12-01

    Climate Change Adaptation (CCA) and Disaster Risk Reduction (DRR) have similar aims and mutual benefits, and there is a very strong rationale for adopting a more integrated approach to these issues rather than analysing each of them as distinct from the other. One of the gaps that have been noted in this context is the lack of evidence in systematic integration of CCA and DRR in Southern Africa. In this regard, this study builds on understanding CCA and DRR policies from the perspectives of vulnerable groups- women and smallholder farmers, and conducts institutional and policy analysis of CCA and DRR in southern Africa, with specific focus on Malawi and Zimbabwe. Both quantitative and qualitative methodologies were employed to collect data for this study in the two countries. The analysis is centred on the conceptualization of DRR in the context of recovery time and CCA on livelihood changes. Findings of the study show that drought is no longer viewed as a hazard as it is a perennial and chronic occurrence in selected climate hotspots, with heightened intensity in certain identified years. Households are able to quickly recover from slow onset hazards such as droughts and dry spells more than they are able to recover from sudden onset floods, implying more capacity towards CCA than DRR. Government programmes and policies are also focused more on CCA than on DRR efforts that appear not to be a priority. Findings point towards female vulnerability from perceptions and practice where males tend to dominate where they are set to benefit from external assistance. We need to strengthen government capacity in implementation of DRR programmes, which is currently limited and development initiatives must deliberately target building the resilience of women.

  9. 4.5-Gb/s RGB-LED based WDM visible light communication system employing CAP modulation and RLS based adaptive equalization.

    PubMed

    Wang, Yiguang; Huang, Xingxing; Tao, Li; Shi, Jianyang; Chi, Nan

    2015-05-18

    Inter-symbol interference (ISI) is one of the key problems that seriously limit transmission data rate in high-speed VLC systems. To eliminate ISI and further improve the system performance, series of equalization schemes have been widely investigated. As an adaptive algorithm commonly used in wireless communication, RLS is also suitable for visible light communication due to its quick convergence and better performance. In this paper, for the first time we experimentally demonstrate a high-speed RGB-LED based WDM VLC system employing carrier-less amplitude and phase (CAP) modulation and recursive least square (RLS) based adaptive equalization. An aggregate data rate of 4.5Gb/s is successfully achieved over 1.5-m indoor free space transmission with the bit error rate (BER) below the 7% forward error correction (FEC) limit of 3.8x10(-3). To the best of our knowledge, this is the highest data rate ever achieved in RGB-LED based VLC systems.

  10. The American Indian Family in Los Angeles: A Comparison of Premigration Experience, Postmigration Residence and Employment Mobility, and Coping Strategies.

    ERIC Educational Resources Information Center

    Weibel, Joan

    Urban adaptation patterns of male and female American Indians were investigated via comparison of premigration statistics (48 Navajo and 40 Oklahoma families) with postmigration statistics on a sample of 23 Navajo and 21 Oklahoma families now living in Los Angeles. The premigration variables were residence patterns; population density;…

  11. An Adaptation Strategy to Address Sea Level Rise Along Coastal Developments

    NASA Astrophysics Data System (ADS)

    Trivedi, D. R.

    2010-12-01

    understanding of acceptable levels of risks, a strategy encompassing the near-term, mid-term, and long term was developed for the projects. Immovable structures such as buildings and vital infrastructure will be raised to above the conservative levels of identified sea level rise. Perimeter improvements would be built to mid-term values with adaptation strategies incorporated into the project documents.

  12. Adaptation to hot climate and strategies to alleviate heat stress in livestock production.

    PubMed

    Renaudeau, D; Collin, A; Yahav, S; de Basilio, V; Gourdine, J L; Collier, R J

    2012-05-01

    Despite many challenges faced by animal producers, including environmental problems, diseases, economic pressure, and feed availability, it is still predicted that animal production in developing countries will continue to sustain the future growth of the world's meat production. In these areas, livestock performance is generally lower than those obtained in Western Europe and North America. Although many factors can be involved, climatic factors are among the first and crucial limiting factors of the development of animal production in warm regions. In addition, global warming will further accentuate heat stress-related problems. The objective of this paper was to review the effective strategies to alleviate heat stress in the context of tropical livestock production systems. These strategies can be classified into three groups: those increasing feed intake or decreasing metabolic heat production, those enhancing heat-loss capacities, and those involving genetic selection for heat tolerance. Under heat stress, improved production should be possible through modifications of diet composition that either promotes a higher intake or compensates the low feed consumption. In addition, altering feeding management such as a change in feeding time and/or frequency, are efficient tools to avoid excessive heat load and improve survival rate, especially in poultry. Methods to enhance heat exchange between the environment and the animal and those changing the environment to prevent or limit heat stress can be used to improve performance under hot climatic conditions. Although differences in thermal tolerance exist between livestock species (ruminants > monogastrics), there are also large differences between breeds of a species and within each breed. Consequently, the opportunity may exist to improve thermal tolerance of the animals using genetic tools. However, further research is required to quantify the genetic antagonism between adaptation and production traits to evaluate

  13. Long-term strategies of climate change adaptation to manage flooding events in urban areas

    NASA Astrophysics Data System (ADS)

    Pouget, Laurent; Russo, Beniamino; Redaño, Angel; Ribalaygua, Jaime

    2010-05-01

    Heavy and sudden rainfalls regularly affect the Mediterranean area, so a great number of people and buildings are exposed to the risk of rain-generated floods. Climate change is expected to modify this risk and, in the case that extreme rainfalls increase in frequencies and intensity, this could result in important damages, particularly in urban areas. This paper presents a project that aims to determine adaptation strategies to future flood risks in urban areas. It has been developed by a panel of water companies (R+i Alliance funding), and includes the evaluation of the climate change impact on the extreme rainfall, the use of innovative modelling tools to accurately forecast the flood risk and, finally, the definition of a pro-active and long-term planning against floods. This methodology has been applied in the city of Barcelona. Current climate models give some projections that are not directly applicable for flood risk studies, either because they do not have an adequate spatial and temporal resolution, or because they do not consider some important local factors, such as orography. These points have been considered within the project, when developing the design storms corresponding to future climatic conditions (e.g. years 2030 or 2050). The methodology uses statistical downscaling techniques based on global climate models predictions, including corrections for extreme events and convective storms, as well as temporal downscaling based on historical observations. The design storms created are used in combination with the predictions of sea level rise and land use evolutions to determine the future risk of flooding in the area of study. Once the boundary conditions are known, an accurate flood hazard assessment is done. It requires a local knowledge of the flow parameters in the whole analyzed domain. In urban catchments, in order to fulfill this requirement, powerful hydrological and hydraulic tools and detailed topographic data represent the unique way for

  14. An adaptive coupling strategy for joint inversions that use petrophysical information as constraints

    NASA Astrophysics Data System (ADS)

    Heincke, Björn; Jegen, Marion; Moorkamp, Max; Hobbs, Richard W.; Chen, Jin

    2017-01-01

    Joint inversion strategies for geophysical data have become increasingly popular as they allow for the efficient combination of complementary information from different data sets. The algorithm used for the joint inversion needs to be flexible in its description of the subsurface so as to be able to handle the diverse nature of the data. Hence, joint inversion schemes are needed that 1) adequately balance data from the different methods, 2) have stable convergence behavior, 3) consider the different resolution power of the methods used and 4) link the parameter models in a way that they are suited for a wide range of applications. Here, we combine active source seismic P-wave tomography, gravity and magnetotelluric (MT) data in a petrophysical joint inversion that accounts for these issues. Data from the different methods are inverted separately but are linked through constraints accounting for parameter relationships. An advantage of performing the inversions separately is that no relative weighting between the data sets is required. To avoid perturbing the convergence behavior of the inversions by the coupling, the strengths of the constraints are readjusted at each iteration. The criterion we use to control the adaption of the coupling strengths is based on variations in the objective functions of the individual inversions from one to the next iteration. Adaption of the coupling strengths makes the joint inversion scheme also applicable to subsurface conditions, where assumed relationships are not valid everywhere, because the individual inversions decouple if it is not possible to reach adequately low data misfits for the made assumptions. In addition, the coupling constraints depend on the relative resolutions of the methods, which leads to an improved convergence behavior of the joint inversion. Another benefit of the proposed scheme is that structural information can easily be incorporated in the petrophysical joint inversion (no additional terms are added

  15. Human Vulnerability to Climate Variability in the Sahel: Farmers' Adaptation Strategies in Northern Burkina Faso

    NASA Astrophysics Data System (ADS)

    Barbier, Bruno; Yacouba, Hamma; Karambiri, Harouna; Zoromé, Malick; Somé, Blaise

    2009-05-01

    In this study, the authors investigate farmers’ vulnerability to climate variability and evaluate local adoption of technology and farmers’ perceptions of adaptation strategies to rainfall variability and policies. A survey was conducted in a community in northern Burkina Faso following the crop failure of 2004. In 2006, following a better harvest, another survey was conducted to compare farmers’ actions and reactions during two contrasted rainy seasons. The results confirm that farmers from this community have substantially changed their practices during the last few decades. They have adopted a wide range of techniques that are intended to simultaneously increase crop yield and reduce yield variability. Micro water harvesting (Zaï) techniques have been widely adopted (41%), and a majority of fields have been improved with stone lines (60%). Hay (48%) and sorghum residues are increasingly stored to feed animals during the dry season, making bull and sheep fattening now a common practice. Dry season vegetable production also involves a majority of the population (60%). According to farmers, most of the new techniques have been adopted because of growing land scarcity and new market opportunities, rather than because of climate variability. Population pressure has reached a critical threshold, while land scarcity, declining soil fertility and reduced animal mobility have pushed farmers to intensify agricultural production. These techniques reduce farmers’ dependency on rainfall but are still insufficient to reduce poverty and vulnerability. Thirty-nine percent of the population remains vulnerable after a good rainy season. Despite farmers’ desire to remain in their own communities, migrations are likely to remain a major source of regular income and form of recourse in the event of droughts.

  16. Motion Analysis of 100 Mediastinal Lymph Nodes: Potential Pitfalls in Treatment Planning and Adaptive Strategies

    SciTech Connect

    Pantarotto, Jason R.; Piet, Anna H.M.; Vincent, Andrew; Soernsen de Koste, John R. van; Senan, Suresh

    2009-07-15

    Purpose: The motion of mediastinal lymph nodes may undermine local control with involved-field radiotherapy. We studied patterns of nodal and tumor motion in 41 patients with lung cancer. Methods and Materials: Four-dimensional (4D) computed tomography planning scans were retrospectively evaluated to identify patients with clearly visible mediastinal lymph nodes. One hundred nodes from 14 patients with Stage I and 27 patients with Stage III were manually contoured in all 4D computed tomography respiratory phases. Motion was derived from changes in the nodal center-of-mass position. Primary tumors were also delineated in all phases for 16 patients with Stage III disease. Statistical analysis included a multivariate mixed-effects model of grouped data. Results: Average 3D nodal motion during quiet breathing was 0.68 cm (range, 0.17-1.64 cm); 77% moved greater than 0.5 cm, and 10% moved greater than 1.0 cm. Motion was greatest in the lower mediastinum (p = 0.002), and nodes measuring 2 cm or greater in diameter showed motion similar to that in smaller nodes. In 11 of 16 patients studied, at least one node moved more than the corresponding primary tumor. No association between 3D primary tumor motion and nodal motion was observed. For mobile primary tumors, phase offsets between the primary tumor and nodes of two or more and three or more phases were observed for 33% and 12% of nodes, respectively. Conclusions: Mediastinal nodal motion is common, with phase offsets seen between the primary tumor and different nodes in the same patient. Patient-specific information is needed to ensure geometric coverage, and adaptive strategies based solely on the primary tumor may be misleading.

  17. YES. The Young-adult Employment Supports Project. School-to-Work Outreach Project 1998 Exemplary Model/Practice/Strategy.

    ERIC Educational Resources Information Center

    Minnesota Univ., Minneapolis. Inst. on Community Integration.

    The Young Adults Employment Supports Project (YES) of Matrix Research Institute (MRI) has been identified as an exemplary school-to-work program that includes students with disabilities. The program serves young persons with serious emotional disorders between the ages of 17-22 throughout Philadelphia who are preparing to exit special education…

  18. A novel kernel extreme learning machine algorithm based on self-adaptive artificial bee colony optimisation strategy

    NASA Astrophysics Data System (ADS)

    Ma, Chao; Ouyang, Jihong; Chen, Hui-Ling; Ji, Jin-Chao

    2016-04-01

    In this paper, we propose a novel learning algorithm, named SABC-MKELM, based on a kernel extreme learning machine (KELM) method for single-hidden-layer feedforward networks. In SABC-MKELM, the combination of Gaussian kernels is used as the activate function of KELM instead of simple fixed kernel learning, where the related parameters of kernels and the weights of kernels can be optimised by a novel self-adaptive artificial bee colony (SABC) approach simultaneously. SABC-MKELM outperforms six other state-of-the-art approaches in general, as it could effectively determine solution updating strategies and suitable parameters to produce a flexible kernel function involved in SABC. Simulations have demonstrated that the proposed algorithm not only self-adaptively determines suitable parameters and solution updating strategies learning from the previous experiences, but also achieves better generalisation performances than several related methods, and the results show good stability of the proposed algorithm.

  19. Enhancing adaptive sparse grid approximations and improving refinement strategies using adjoint-based a posteriori error estimates

    DOE PAGES

    Jakeman, J. D.; Wildey, T.

    2015-01-01

    In this paper we present an algorithm for adaptive sparse grid approximations of quantities of interest computed from discretized partial differential equations. We use adjoint-based a posteriori error estimates of the interpolation error in the sparse grid to enhance the sparse grid approximation and to drive adaptivity. We show that utilizing these error estimates provides significantly more accurate functional values for random samples of the sparse grid approximation. We also demonstrate that alternative refinement strategies based upon a posteriori error estimates can lead to further increases in accuracy in the approximation over traditional hierarchical surplus based strategies. Throughout this papermore » we also provide and test a framework for balancing the physical discretization error with the stochastic interpolation error of the enhanced sparse grid approximation.« less

  20. Enhancing adaptive sparse grid approximations and improving refinement strategies using adjoint-based a posteriori error estimates

    SciTech Connect

    Jakeman, J. D.; Wildey, T.

    2015-01-01

    In this paper we present an algorithm for adaptive sparse grid approximations of quantities of interest computed from discretized partial differential equations. We use adjoint-based a posteriori error estimates of the interpolation error in the sparse grid to enhance the sparse grid approximation and to drive adaptivity. We show that utilizing these error estimates provides significantly more accurate functional values for random samples of the sparse grid approximation. We also demonstrate that alternative refinement strategies based upon a posteriori error estimates can lead to further increases in accuracy in the approximation over traditional hierarchical surplus based strategies. Throughout this paper we also provide and test a framework for balancing the physical discretization error with the stochastic interpolation error of the enhanced sparse grid approximation.

  1. Dosimetric and geometric evaluation of a hybrid strategy of offline adaptive planning and online image guidance for prostate cancer radiotherapy.

    PubMed

    Liu, Han; Wu, Qiuwen

    2011-08-07

    For prostate cancer patients, online image-guided (IG) radiotherapy has been widely used in clinic to correct the translational inter-fractional motion at each treatment fraction. For uncertainties that cannot be corrected online, such as rotation and deformation of the target volume, margins are still required to be added to the clinical target volume (CTV) for the treatment planning. Offline adaptive radiotherapy has been implemented to optimize the treatment for each individual patient based on the measurements at early stages of treatment process. It has been shown that offline adaptive radiotherapy can effectively reduce the required margin. Recently a hybrid strategy of offline adaptive replanning and online IG was proposed and the geometric evaluation was performed. It was found that the planning margins can further be reduced by 1-2 mm compared to online IG only strategy. The purpose of this study was to investigate the dosimetric benefits of such a hybrid strategy on the target and organs at risk. A total of 420 repeated helical computed tomography scans from 28 patients were included in the study. Both low-risk patients (LRP, CTV = prostate) and intermediate-risk patients (IRP, CTV = prostate + seminal vesicles, SV) were included in the simulation. Two registration methods, based on center-of-mass shift of prostate only and prostate plus SV, were performed for IRP. The intensity-modulated radiotherapy was used in the simulation. Criteria on both cumulative and fractional doses were evaluated. Furthermore, the geometric evaluation was extended to investigate the optimal number of fractions necessary to construct the internal target volume (ITV) for the hybrid strategy. The dosimetric margin improvement was smaller than its geometric counterpart and was in the range of 0-1 mm. The optimal number of fractions necessary for the ITV construction is 2 for LRPs and 3-4 for IRPs in a hypofractionation protocol. A new cumulative index of target volume was proposed

  2. Dosimetric and geometric evaluation of a hybrid strategy of offline adaptive planning and online image guidance for prostate cancer radiotherapy

    NASA Astrophysics Data System (ADS)

    Liu, Han; Wu, Qiuwen

    2011-08-01

    For prostate cancer patients, online image-guided (IG) radiotherapy has been widely used in clinic to correct the translational inter-fractional motion at each treatment fraction. For uncertainties that cannot be corrected online, such as rotation and deformation of the target volume, margins are still required to be added to the clinical target volume (CTV) for the treatment planning. Offline adaptive radiotherapy has been implemented to optimize the treatment for each individual patient based on the measurements at early stages of treatment process. It has been shown that offline adaptive radiotherapy can effectively reduce the required margin. Recently a hybrid strategy of offline adaptive replanning and online IG was proposed and the geometric evaluation was performed. It was found that the planning margins can further be reduced by 1-2 mm compared to online IG only strategy. The purpose of this study was to investigate the dosimetric benefits of such a hybrid strategy on the target and organs at risk. A total of 420 repeated helical computed tomography scans from 28 patients were included in the study. Both low-risk patients (LRP, CTV = prostate) and intermediate-risk patients (IRP, CTV = prostate + seminal vesicles, SV) were included in the simulation. Two registration methods, based on center-of-mass shift of prostate only and prostate plus SV, were performed for IRP. The intensity-modulated radiotherapy was used in the simulation. Criteria on both cumulative and fractional doses were evaluated. Furthermore, the geometric evaluation was extended to investigate the optimal number of fractions necessary to construct the internal target volume (ITV) for the hybrid strategy. The dosimetric margin improvement was smaller than its geometric counterpart and was in the range of 0-1 mm. The optimal number of fractions necessary for the ITV construction is 2 for LRPs and 3-4 for IRPs in a hypofractionation protocol. A new cumulative index of target volume was proposed

  3. Sustainability of forest management under changing climatic conditions in the southern United States: adaptation strategies, economic rents and carbon sequestration.

    PubMed

    Susaeta, Andres; Carter, Douglas R; Adams, Damian C

    2014-06-15

    The impacts of climate change on profitability and carbon storage in even-aged forest stands of two dominant commercial pine species, loblolly and slash pine, in the southern United States were assessed under alternative assumptions about the impact of climate change on forest productivity and catastrophic disturbance rates. Potential adaptation strategies to reduce losses from disturbance included: 1) alternative planting densities, and 2) planting slash pine instead of loblolly pine. In addition, the amount of sequestered carbon was used to develop an index of economic efficiency for carbon sequestration, which further helps rank the suitability of alternative adaptation strategies. Our results indicate that greater economic rents from forests occur with lower planting densities and the substitution of slash pine for high density loblolly pine. However, less carbon is sequestered by low density loblolly pine compared to slash pine and high density loblolly pine. Both adaptation strategies are economically more effective in terms of carbon sequestration compared to the baseline since they generate more economic revenues per Mg of sequestered carbon.

  4. Changing Minds with the Story of Adaptation: Strategies for Teaching Young Children about Natural Selection

    ERIC Educational Resources Information Center

    Emmons, Natalie; Smith, Hayley; Kelemen, Deborah

    2016-01-01

    Research Findings: Educational guidelines recommend a delayed, piecemeal approach to instruction on adaptation by natural selection. This approach is questionable given suggestions that older students' pervasive misunderstandings about adaptation are rooted in cognitive biases that develop early. In response to this, Kelemen et al. (2014) recently…

  5. Skills, Standards and Entry-Level Work. Elements of a Strategy for Youth Employability Development. Research and Evaluation Report Series.

    ERIC Educational Resources Information Center

    MacAllum, Keith; Ma, Patricia

    Can public policy devise effective strategies that seek to capitalize on the educational and developmental potential of private-sector entry-level jobs? What is the feasibility of using the secondary labor market in a formal way to promote skill development in youth? Can youth develop useful and transferable skills in these jobs? How can these…

  6. Progress in the Inductive Strategy-Use of Children from Different Ethnic Backgrounds: A Study Employing Dynamic Testing

    ERIC Educational Resources Information Center

    Resing, Wilma C. M.; Touw, Kirsten W. J.; Veerbeek, Jochanan; Elliott, Julian G.

    2017-01-01

    This study investigated potential differences in inductive behavioural and verbal strategy-use between children (aged 6-8 years) from indigenous and non-indigenous backgrounds. This was effected by the use of an electronic device that could present a series of tasks, offer scaffolded assistance and record children's responses. Children from…

  7. Renewable energy to develop adaptation strategies to the climate change conditions

    NASA Astrophysics Data System (ADS)

    Servadio, Pieranna; Bergonzoli, Simone

    2013-04-01

    Changes in land use and combustion of fossil fuels have been largest human impact on the global carbon cycle and without a complete accounting of net greenhouse-gas (GHG) fluxes, developing and evaluating adaptation strategies are not possible. The major source of GHG fluxes associated with crop production are soil N2O emissions, soil CO2 and methane (CH4) fluxes, and CO2 emission associated with agricultural inputs and farm equipment operation. This study points out the main principles which are at the base of solar energy use for sustainability of irrigated agriculture. Field tests were carried out in order to compare crop yield and solar pump plant performance, for the photovoltaic conversion of solar energy, connected to drip irrigation and sprinkler system plants during the irrigation season. The system mainly consists of the parts listed here: set of flat photovoltaic panels consisting of 150 panels for a total of 3000 W peak value once installed, connected in serial-parallel to obtain a 120 Vdc operating voltage rating. The panels utilize 36 serially connected single-crystal silicon cells providing a 12 V voltage rating. The serial connection of 10 panels generates the system's operating voltage rating (120 Vdc). The total 3000 W peak value power is obtained by connecting in parallel 15 serial-strings. When the circuit is open, the voltage at the ends of the panels can reach 210 Volts. The photovoltaic system supplies, through an inverter, a three-phase 1.6 kW canned pump located in the artesian well. The relevant hydraulic line connects this pump to the various utilities. The hydraulic capacity of the helium pump has been used during the irrigation season in order to meet the water needs of a corn crop. Therefore, along with the solar pump was used a dispersing wing type drip irrigation system with double chamber hosing (70 kPa operating pressure), with external holes spaced 0.3 m apart, 0.75 m distance between the wings, wing length 120 m and placed

  8. Adaptation strategies to seasonal changes in environmental conditions of a domesticated horse breed, the Shetland pony (Equus ferus caballus).

    PubMed

    Brinkmann, Lea; Gerken, Martina; Riek, Alexander

    2012-04-01

    Recent results suggest that the wild ancestor of the horse, the Przewalski horse, exhibits signs of a hypometabolism. However, there are speculations that domestic animals lost the ability to reduce energy expenditure during food shortage and adverse environmental conditions. Therefore, we investigated physiological and behavioural strategies employed by a robust domesticated horse breed, the Shetland pony, over the course of a year under temperate conditions by measuring ambient temperature (T(a)), subcutaneous temperature (T(s)), locomotor activity (LA), lying time, resting heart rate, body mass and body condition score. Ten animals were kept on pasture in summer and in open stables in winter; further, in winter the animals were allocated into one control and one feed-restricted group of five animals each to simulate natural seasonal food shortage. The annual course of the mean daily T(s) of all horses showed distinct fluctuations from a mean of 35.6±0.5°C, with higher variations in summer than in winter. Diurnal amplitudes in T(s) were highest (P<0.001) in April (12.6°C) and lowest in January (4.0°C), with a nadir around dawn and a peak around mid-day. The feed-restricted group had a significantly lower daily T(s) compared with the control group on cold winter days, with T(a) values below 0°C. Mean annual heart rate and LA followed T(a) closely. Heart rate of the feed-restricted animals significantly decreased from a mean of 52.8±8.1 beats min(-1) in summer to 29±3.9 beats min(-1) in winter and differed from the control group (P<0.001). Mean daily LA was lowest at the end of winter (7000 activity impulses day(-1)) and highest in summer (25,000 activity impulses day(-1)). Our results show that Shetland ponies exhibit signs of a winter hypometabolism indicated by reduced heart rate and T(s). Thus, domesticated horses seem to have maintained the capacity for seasonal adaptation to environmental conditions by seasonal fluctuations in their metabolic rate.

  9. Future tendencies of climate indicators important for adaptation and mitigation strategies in forestry

    NASA Astrophysics Data System (ADS)

    Galos, Borbala; Hänsler, Andreas; Gulyas, Krisztina; Bidlo, Andras; Czimber, Kornel

    2014-05-01

    impact analyses and build an important basis of the future adaptation strategies in forestry, agriculture and water management. Funding: The research is supported by the TÁMOP-4.2.2.A-11/1/KONV-2012-0013 and TÁMOP-4.1.1.C-12/1/KONV-2012-0012 (ZENFE) joint EU-national research projects. Keywords: climate indices, climate change impacts, forestry, regional climate modelling

  10. Water Reserves Program. An adaptation strategy to balance water in nature

    NASA Astrophysics Data System (ADS)

    Lopez Perez, M.; Barrios, E.; Salinas-Rodriguez, S.; Wickel, B.; Villon, R. A.

    2013-05-01

    -allocation takes place. The strategy is to identify and protect basins with an availability of water that is close to their natural flow regime and that also have a high conservation value (based on prior national conservation priority definitions such as protected areas, and biodiversity conservation gap analyses) in order to implement legal restrictions on water resource development. With such protection, these systems will be best positioned to adjust and respond to water shortages, and regime shifts. To date, 189 basins around the country were identified as potential water reserves. The next step will be the nomination of these water reserves to be integrated in the National Water Reserves Program. This program forms the core of the official Mexican government adaptation strategy towards climate prepared water management, which recognizes that water reserves are the buffer society needs to face uncertainty, and reduce water scarcity risk. The development of activities that alter the natural flow regime such as dams and levees are closely examined, and would potentially be restricted.

  11. Water Reserves Program. An adaptation strategy to prevent imbalance of water in nature

    NASA Astrophysics Data System (ADS)

    Salinas-Rodriguez, S. A.; López Pérez, M.; Barrios Ordóñez, J.; Wickel, B.; Villón Bracamonte, R. A.

    2013-12-01

    allocated, and where the flow regime is then protected before over-allocation takes place. The strategy has been to identify and protect basins with an availability of water that is close to their natural flow regime and that also have a high conservation value (based on prior national conservation priority definitions such as protected areas, and biodiversity conservation gap analyses) in order to implement legal restrictions on water resource development. With such protection, these systems will be best positioned to adjust and respond to water shortages, and regime shifts. To date, 189 basins around the country were identified as potential water reserves. The next step will be the nomination of these water reserves to be integrated in the National Water Reserves Program. This program forms the core of the official Mexican government adaptation strategy towards climate prepared water management, which recognizes that water reserves are the buffer society needs to face uncertainty, imbalance of the man-made, global changes, and thus to reduce water scarcity risk. The development of activities that alter the natural flow regime such as dams and levees are closely examined, and would potentially be restricted.

  12. Offline multiple adaptive planning strategy for concurrent irradiation of the prostate and pelvic lymph nodes

    SciTech Connect

    Qi, Peng; Xia, Ping; Pouliot, Jean; Roach, Mack

    2014-02-15

    Purpose: Concurrent irradiation of the prostate and pelvic lymph nodes (PLNs) can be challenging due to the independent motion of the two target volumes. To address this challenge, the authors have proposed a strategy referred to as Multiple Adaptive Planning (MAP). To minimize the number of MAP plans, the authors’ previous work only considered the prostate motion in one major direction. After analyzing the pattern of the prostate motion, the authors investigated a practical number of intensity-modulated radiotherapy (IMRT) plans needed to accommodate the prostate motion in two major directions simultaneously. Methods: Six patients, who received concurrent irradiation of the prostate and PLNs, were selected for this study. Nine MAP-IMRT plans were created for each patient with nine prostate contours that represented the prostate at nine locations with respect to the PLNs, including the original prostate contour and eight contours shifted either 5 mm in a single anterior-posterior (A-P), or superior-inferior (S-I) direction, or 5 mm in both A-P and S-I directions simultaneously. From archived megavoltage cone beam CT (MV-CBCT) and a dual imaging registration, 17 MV-CBCTs from 33 available MV-CBCT from these patients showed large prostate displacements (>3 mm in any direction) with respect to the pelvic bones. For each of these 17 fractions, one of nine MAP-IMRT plans was retrospectively selected and applied to the MV-CBCT for dose calculation. For comparison, a simulated isocenter-shifting plan and a reoptimized plan were also created for each of these 17 fractions. The doses to 95% (D95) of the prostate and PLNs, and the doses to 5% (D5) of the rectum and bladder were calculated and analyzed. Results: For the prostate, D95 > 97% of the prescription dose was observed in 16, 16, and 17 of 17 fractions for the MAP, isocenter-shifted, and reoptimized plans, respectively. For PLNs, D95 > 97% of the prescription doses was observed in 10, 3, and 17 of 17 fractions for

  13. Adaptation Strategies to Climate Change and the Role of Planning Instruments - The Example of the Dresden Region (Saxony/Germany)

    NASA Astrophysics Data System (ADS)

    Albrecht, J.; Juta, K.; Nobis, A.

    2009-04-01

    In the past, identifying anthropogenic influences on climate change, scenario analyses and issues of climate change mitigation were predominant approaches in climate change research (IPCC 2007). Currently, for instance in Germany, climate impact research on regional level comes to the forefront of research and policy making. Climate change has become an important topic on the agenda of politicians, administration and planning. In order to counteract the (unavoidable) climate change and its impacts it is necessary to develop adaptation strategies. At present, such strategies and guidelines are formulated on international, supranational and national level. The initial point was the United Nations Framework Convention on Climate Change in 1992 where the contracting states obligated themselves to develop national (and regional) programmes for adaptation. In 2007 the European Commission published its Green Paper called Adaptation to Climate Change in Europe. The paper states that adaptation efforts have to be intensified at different (spatial) levels (local, regional, national, and so forth). Furthermore, coordinating these efforts is of high importance. With the recent agreement on the German Adaptation Strategy to Climate Change (DAS 2008) in December 2008, federal government tries to accomplish this task. The German strategy mainly focuses on two elements: decreasing vulnerability and increasing adaptability. While the above mentioned strategies have presented information and policies concerning climate change and adaptation on international, supranational and national level, such documents dońt yet exist on regional level. However, because of their close link to the local level the regions are of high importance for adaptation strategies. Therefore, the Leibniz-Institute of Ecological and Regional Development developed a transdisciplinary project to formulate and implement the so-called Integrated Regional Climate Adaptation Programme (IRCAP) for the Model Region

  14. The Jakobsonian One-Stem Analysis of the Russian Verb: Adaptations and Pedagogical Strategies.

    ERIC Educational Resources Information Center

    Gaines, Billie D.

    1982-01-01

    The evolution of one-stem verb theory since Roman Jakobson's 1948 study of Russian conjugation is outlined, and adaptations of his one-stem conjugation methodology for current classroom use are discussed and compared. (MSE)

  15. Adapting agriculture to climate change in Kenya: household strategies and determinants.

    PubMed

    Bryan, Elizabeth; Ringler, Claudia; Okoba, Barrack; Roncoli, Carla; Silvestri, Silvia; Herrero, Mario

    2013-01-15

    Countries in Sub-Saharan Africa are particularly vulnerable to climate change, given dependence on agricultural production and limited adaptive capacity. Based on farm household and Participatory Rural Appraisal data collected from districts in various agroecological zones in Kenya, this paper examines farmers' perceptions of climate change, ongoing adaptation measures, and factors influencing farmers' decisions to adapt. The results show that households face considerable challenges in adapting to climate change. While many households have made small adjustments to their farming practices in response to climate change (in particular, changing planting decisions), few households are able to make more costly investments, for example in agroforestry or irrigation, although there is a desire to invest in such measures. This emphasizes the need for greater investments in rural and agricultural development to support the ability of households to make strategic, long-term decisions that affect their future well-being.

  16. Developing DNP students as adaptive leaders: a key strategy in transforming health care.

    PubMed

    Kendall-Gallagher, Deborah; Breslin, Eileen

    2013-01-01

    The success of graduates with a doctor of nursing practice (DNP) degree in transforming health care will depend significantly on their leadership ability to think strategically, innovate, and engage stakeholders in meaningful system improvement. Known as adaptive work, these graduates will need a portfolio of adaptive leadership skills that prepare them to move health care from a volume-driven to value-based system. This article describes development of a core DNP leadership course in a postmaster's point of entry DNP program at an academic health science center school of nursing. The course, designed as DNP students' initial step on their professional development journey to becoming adaptive leaders capable of driving transformative change, created an alternative lens for students to undertake strategic adaptive change initiatives within themselves and their organizations.

  17. Developing an Adaptability Training Strategy and Policy for the DoD

    DTIC Science & Technology

    2008-10-01

    One reviewer observed: From a neuroscience perspective, adaptability is a core function of the brain and related neural systems. The nervous system...IDA model, but also of individual predispositions and organizational openness. Though neuroscience recognizes adaptability as a core function of the...Moore at the National Security Agency ( NSA ), who teaches critical thinking there and has published a lengthy paper on the subject.51 NSA offers a

  18. Long term post-flood damage assessments to analyze the strategies of adaptation at individual scale

    NASA Astrophysics Data System (ADS)

    Brémond, Pauline; Bonte, Bruno; Erdlenbruch, Katrin; Grelot, Frédéric; Richert, Claire

    2015-04-01

    RETINA is a project which studies the opportunity for adaptation in the aftermath of flood events. To handle this research question, we consider adaptation to flood risk at individual and collective scale as well as the influence of the urban planning regulation (Flood risk mapping). For the purpose of this research, collective adaptation means actions that are undertaken at collective scale such as dikes, relocation of collective infrastructures (roads, treatment plant...) and individual adaptation means actions decided at individual level (households, enterprises or farmers) such as relocation, elevation of critical components, new organization.... In this presentation, we focus on individual adaptation and analyse which are the mechanisms that incite or constrain the adaptation to flood risk of individual assets considering their own trajectory. The originality of our approach is to carry out long term post-flood assessments and comprehensive interviews at individual scale. To catch the drivers of adaptation, we sequenced the interview guide in three periods: 1/ the situation before the reference event occurred, 2/ what happened during and just after the flood event, 3/ what happened from the flood event until the moment of the interview. Two case studies have been chosen. The first case study is the Aude department where an exceptional flooding occurred in 1999. The second case study is the Var department where more recent and frequent flood events occurred in 2010, 2011, 2014. On each case study, we plan to conduct about fifty interviews including households and economic activities. In this presentation, we will develop methodological aspects on long term post-flood damage assessments. Carrying out a long term post-flood assessment enabled us to consider adaptation to flood risk among the whole of strategic decisions a household or an enterprise has to take. Moreover, we found out that contrary to what is usually assumed, the fact that the reference event was

  19. COREDAR: COmmunicating Risk of sea level rise and Engaging stakeholDers in framing community based Adaptation stRategies

    NASA Astrophysics Data System (ADS)

    Amsad Ibrahim Khan, S. K.; Chen, R. S.; de Sherbinin, A. M.; Andimuthu, R.; Kandasamy, P.

    2015-12-01

    Accelerated sea-level rise (SLR) is a major long term outcome of climate change leading to increased inundation of low-lying areas. Particularly, global cities that are located on or near the coasts are often situated in low lying areas and these locations put global cities at greater risk to SLR. Localized flooding will profoundly impact vulnerable communities located in high-risk urban areas. Building community resilience and adapting to SLR is increasingly a high priority for cities. On the other hand, Article 6 of the United Nations Framework Convention on Climate Change addresses the importance of climate change communication and engaging stakeholders in decision making process. Importantly, Community Based Adaptation (CBA) experiences emphasize that it is important to understand a community's unique perceptions of their adaptive capacities to identify useful solutions and that scientific and technical information on anticipated coastal climate impacts needs to be translated into a suitable language and format that allows people to be able to participate in adaptation planning. To address this challenge, this study has put forth three research questions from the lens of urban community engagement in SLR adaptation, (1) What, if any, community engagement in addressing SLR occurring in urban areas; (2) What information do communities need and how does it need to be communicated, in order to be better prepared and have a greater sense of agency? and (3) How can government agencies from city to federal levels facilitate community engagement and action?. To answer these questions this study has evolved a framework "COREDAR" (COmmunicating Risk of sea level rise and Engaging stakeholDers in framing community based Adaptation StRategies) to communicate and transfer complex climate data and information such as projected SLR under different scenarios of IPCC AR5, predicted impact of SLR, prioritizing vulnerability, etc. to concerned stakeholders and local communities

  20. Job-Search Strategies and Reemployment Quality: The Impact of Career Adaptability

    ERIC Educational Resources Information Center

    Koen, Jessie; Klehe, Ute-Christine; Van Vianen, Annelies E. M.; Zikic, Jelena; Nauta, Aukje

    2010-01-01

    Past job-search research has focused on how hard unemployed people search for a job, but we still know little about the strategies that people use during their search and how we can predict the quality of the reemployment found. The first aim of this study was to predict the use of different job-search strategies via job-seekers' career…

  1. "Meatless days" or "less but better"? Exploring strategies to adapt Western meat consumption to health and sustainability challenges.

    PubMed

    de Boer, Joop; Schösler, Hanna; Aiking, Harry

    2014-05-01

    Adapting Western meat consumption to health and sustainability challenges requires an overall reduction of industrially produced animal proteins plus a partial replacement by plant proteins. Combining insights on food, environment, and consumers, this paper aims to explore change strategies that may help to meet these challenges, such as promoting smaller portions of meat ("less"), smaller portions using meat raised in a more sustainable manner ("less but better"), smaller portions and eating more vegetable protein ("less and more varied"), and meatless meals with or without meat substitutes ("veggie-days"). The underlying logic of the strategies was clarified by analyzing dietary choices. A nationwide sample of 1083 Dutch consumers provided information on current eating practices and potential changes. The results show that strategies to change meat eating frequencies and meat portion sizes will appeal to overlapping but partly different segments of consumers and that these strategies can be applied to address consumers in terms of their own preferences. The strategies appeared to have different strengths and weaknesses, making them complementary pathways to facilitate step-by-step changes in the amounts and the sources of protein consumed.

  2. Gasoline-like Fuel Effects on High-load, Boosted HCCI Combustion Employing Negative Valve Overlap Strategy

    SciTech Connect

    Kalaskar, Vickey B; Szybist, James P; Splitter, Derek A

    2014-01-01

    In recent years a number of studies have demonstrated that boosted operation combined with external EGR is a path forward for expanding the high load limit of homogeneous charge compression ignition (HCCI) operation with the negative valve overlap (NVO) valve strategy. However, the effects of fuel composition with this strategy have not been fully explored. In this study boosted HCCI combustion is investigated in a single-cylinder research engine equipped with direct injection (DI) fueling, cooled external exhaust gas recirculation (EGR), laboratory pressurized intake air, and a fully-variable hydraulic valve actuation (HVA) valve train. Three fuels with significant compositional differences are investigated: regular grade gasoline (RON = 90.2), 30% ethanol-gasoline blend (E30, RON = 100.3), and 24% iso-butanol-gasoline blend (IB24, RON = 96.6). Results include engine loads from 350 to 800 kPa IMEPg for all fuels at three engine speeds 1600, 2000, and 2500 rpm. All operating conditions achieved thermal efficiency (gross indicated efficiency) between 38 and 47%, low NOX emissions ( 0.1 g/kWh), and high combustion efficiency ( 96.5%). Detailed sweeps of intake manifold pressure (atmospheric to 250 kPaa), EGR (0 25% EGR), and injection timing are conducted to identify fuel-specific effects. The major finding of this study is that while significant fuel compositional differences exist, in boosted HCCI operation only minor changes in operational conditions are required to achieve comparable operation for all fuels. In boosted HCCI operation all fuels were able to achieve matched load-speed operation, whereas in conventional SI operation the fuel-specific knock differences resulted in significant differences in the operable load-speed space. Although all fuels were operable in boosted HCCI, the respective air handling requirements are also discussed, including an analysis of the demanded turbocharger efficiency.

  3. Simultaneously selecting appropriate partners for gaming and strategy adaptation to enhance network reciprocity in the prisoner's dilemma

    NASA Astrophysics Data System (ADS)

    Tanimoto, Jun

    2014-01-01

    Network reciprocity is one mechanism for adding social viscosity, which leads to cooperative equilibrium in 2 × 2 prisoner's dilemma games. Previous studies have shown that cooperation can be enhanced by using a skewed, rather than a random, selection of partners for either strategy adaptation or the gaming process. Here we show that combining both processes for selecting a gaming partner and an adaptation partner further enhances cooperation, provided that an appropriate selection rule and parameters are adopted. We also show that this combined model significantly enhances cooperation by reducing the degree of activity in the underlying network; we measure the degree of activity with a quantity called effective degree. More precisely, during the initial evolutionary stage in which the global cooperation fraction declines because initially allocated cooperators becoming defectors, the model shows that weak cooperative clusters perish and only a few strong cooperative clusters survive. This finding is the most important key to attaining significant network reciprocity.

  4. Simultaneously selecting appropriate partners for gaming and strategy adaptation to enhance network reciprocity in the prisoner's dilemma.

    PubMed

    Tanimoto, Jun

    2014-01-01

    Network reciprocity is one mechanism for adding social viscosity, which leads to cooperative equilibrium in 2 × 2 prisoner's dilemma games. Previous studies have shown that cooperation can be enhanced by using a skewed, rather than a random, selection of partners for either strategy adaptation or the gaming process. Here we show that combining both processes for selecting a gaming partner and an adaptation partner further enhances cooperation, provided that an appropriate selection rule and parameters are adopted. We also show that this combined model significantly enhances cooperation by reducing the degree of activity in the underlying network; we measure the degree of activity with a quantity called effective degree. More precisely, during the initial evolutionary stage in which the global cooperation fraction declines because initially allocated cooperators becoming defectors, the model shows that weak cooperative clusters perish and only a few strong cooperative clusters survive. This finding is the most important key to attaining significant network reciprocity.

  5. Concluding remarks: nutritional strategies to support the adaptive response to prolonged exercise training.

    PubMed

    van Loon, Luc J C; Tipton, Kevin D

    2013-01-01

    Nutrition plays a key role in allowing the numerous training hours to be translated into useful adaptive responses of various tissues in the individual athlete. Research over the last decade has shown many examples of the impact of dietary interventions to modulate the skeletal muscle adaptive response to prolonged exercise training. Proper nutritional coaching should be applied throughout both training and competition, each with their specific requirements regarding nutrient provision. Such dietary support will improve exercise training efficiency and, as such, further increase performance capacity. Here, we provide an overview on the properties of various nutritional interventions that may be useful to support the adaptive response to exercise training and competition and, as such, to augment exercise training efficiency.

  6. An adaptive time-stepping strategy for solving the phase field crystal model

    SciTech Connect

    Zhang, Zhengru; Ma, Yuan; Qiao, Zhonghua

    2013-09-15

    In this work, we will propose an adaptive time step method for simulating the dynamics of the phase field crystal (PFC) model. The numerical simulation of the PFC model needs long time to reach steady state, and then large time-stepping method is necessary. Unconditionally energy stable schemes are used to solve the PFC model. The time steps are adaptively determined based on the time derivative of the corresponding energy. It is found that the use of the proposed time step adaptivity cannot only resolve the steady state solution, but also the dynamical development of the solution efficiently and accurately. The numerical experiments demonstrate that the CPU time is significantly saved for long time simulations.

  7. Incidence of Sitophilus oryzae and other stored-product pests on cowpea in local markets in Accra: management strategies employed by retailers.

    PubMed

    Egbon, I N; Ayertey, J N

    2013-05-01

    In recent times, the unusual presence of Sitophilus on cowpea has become an issue in Ghana as it constitutes a threat to food sufficiency and food security; this, by extension, necessitated the execution of this survey to establish the specific identity of the insect and its incidence, on stored cowpea in Ghana and consequently assess the level of awareness of traders and the management strategies employed. Using internal morphological identification techniques, the insect was identified as Sitophilus oryzae with an incidence rate of 12, 22 and 20% as against 50, 41 and 42% incidence rate of Callosobruchus maculatus after 30, 60 and 90 days respectively, of undisturbed storage of cowpea within the marketing systems in Accra, Ghana. Relatively low number of retailers (35.44%, N = 79) was aware of this occurrence, with 91.14% of this employing the energy-demanding and time-consuming sieving techniques as their main control strategies. This paper draws attention to the possible worsening of food insecurity already eminent in Africa for insects are no respecters of international or geo-political boundaries as they can spread to other countries, should this observation be left unchecked.

  8. Perceived Risks and Protective Strategies Employed by Young Men Who Have Sex with Men (YMSM) when Seeking Online Sexual Partners

    PubMed Central

    Bauermeister, José A.; Giguere, Rebecca; Carballo-Diéguez, Alex; Ventuneac, Ana; Eisenberg, Anna

    2009-01-01

    This study examined young men who have sex with men’s (YMSM) perceptions of risk regarding meeting sexual partners through the Internet. YMSM (N = 54; ages 18–29) who reported engaging in bareback sex (“intentional unprotected anal intercourse in high-risk contexts”) completed a structured assessment and a face-to-face interview. Participants reported using the Internet to meet sexual partners at least once per week, having had multiple sexual partners in the past two months (M = 10.50, SD = 9.25), and engaging in occasions of unprotected receptive (M = 5.35, SD = 6.76) and insertive (M = 5.06, SD = 10.11) anal intercourse. A third of the sample reported having had unprotected sex with a partner who was serodiscordant or of unknown serostatus. Despite the obvious HIV risks, the most commonly perceived risks included threats to physical safety and difficulties trusting a stranger. Risk reduction strategies included leaving information about partner and whereabouts with a friend, meeting in a public place, and screening partner through online chatting. YMSM who meet partners online may be at risk for physical violence in addition to HIV/STIs infection. Public health campaigns should increase awareness of safety concerns when meeting sexual partners online and support YMSM’s self-protective actions. PMID:20812127

  9. Conservation strategies to adapt to projected climate change impacts in Malawi

    Technology Transfer Automated Retrieval System (TEKTRAN)

    There is potential for climate change to have negative effects on agricultural production via extreme events (Pruski and Nearing, 2002b; Zhang et al., 2012; Walthall 2012), and there is a need to implement conservation practices for climate change adaptation (Delgado et al. 2011; 2013). Recent repo...

  10. Strategies for Adapting WebQuests for Students with Learning Disabilities

    ERIC Educational Resources Information Center

    Skylar, Ashley A.; Higgins, Kyle; Boone, Randall

    2007-01-01

    WebQuests are gaining popularity as teachers explore using the Internet for guided learning activities. A WebQuest involves students working on a task that is broken down into clearly defined steps. Students often work in groups to actively conduct the research. This article suggests a variety of methods for adapting WebQuests for students with…

  11. [The impact of religious coping on adaptation strategy among the sick].

    PubMed

    Debout, Christophe

    2015-10-01

    The influence of religious practice on sick people's adaptation processes has been demonstrated in many studies. It is important for the clinical reasoning implemented by caregivers to integrate this aspect in a context defined by the principle of "laïcité" as understood in France.

  12. Group-Work in the Design of Complex Adaptive Learning Strategies

    ERIC Educational Resources Information Center

    Mavroudi, Anna; Hadzilacos, Thanasis

    2013-01-01

    This paper presents a case study where twelve graduate students undertook the demanding role of the adaptive e-course developer and worked collaboratively on an authentic and complex design task in the context of open and distance tertiary education. The students had to work in groups in order to conceptualise and design a learning scenario for…

  13. Behaviorally Mediated, Warm Adaptation: A Physiological Strategy When Mice Are Allowed to Behaviorally Thermoregulate

    EPA Science Inventory

    Laboratory mice housed under standard vivarium conditions with an ambient temperature (Ta) of -22°C are likely to be cold stressed because this Ta is below their thermoneutral zone (TNZ). Mice raised at Tas within the TNZ adapt to the warmer temperatures, developing smaller int...

  14. Investigating Purposeful Science Curriculum Adaptation as a Strategy to Improve Teaching and Learning

    ERIC Educational Resources Information Center

    Debarger, Angela Haydel; Penuel, William R.; Moorthy, Savitha; Beauvineau, Yves; Kennedy, Cathleen A.; Boscardin, Christy Kim

    2017-01-01

    In this paper, we investigate the potential and conditions for using curriculum adaptation to support reform of science teaching and learning. With each wave of reform in science education, curriculum has played a central role and the contemporary wave focused on implementation of the principles and vision of the "Framework for K-12 Science…

  15. Play Therapy for Bereaved Children: Adapting Strategies to Community, School, and Home Settings

    ERIC Educational Resources Information Center

    Webb, Nancy Boyd

    2011-01-01

    Play therapy is a highly adaptable treatment method that can be modified according to children's ages, circumstances, and settings in which counseling occurs. Play therapy may be used in schools, community settings, and homes to help children following the death of a significant other. After reviewing basic developmental factors that affect…

  16. Learner Control versus Program Control as Adaptive Strategies for Selection of Instructional Support on Math Rules.

    ERIC Educational Resources Information Center

    Ross, Steven M.; Rakow, Ernest A.

    1981-01-01

    Subjects completed a self-paced lesson on math rules in which the number of supporting examples was adapted to pretest scores through program control, selected through learner control, or kept constant (nonadaptive). Program control means were consistently highest while learner control means were lowest. (Author/BW)

  17. Towards an integrated agenda for adaptation research: theory, practice, and policy: Strategy paper

    SciTech Connect

    Wilbanks, Thomas J; Patwardhan, Anand; Downing, Tom; Leary, Neil

    2009-01-01

    Adaptation to the adverse impacts of climate change has been recognized as a priority area for national and international policy. The findings of the Fourth Assessment Report of the IPCC have reemphasized the urgency of action and the scale of response needed to cope with climate change outcomes. The scientific community has an important role to play in advancing the information and knowledge base that would help in identifying, developing and implementing effective responses to enhance adaptive capacity and reduce vulnerability. This paper examines the way in which science and research could advance the adaptation agenda. To do so, we pose a number of questions aimed at identifying the knowledge gaps and research needs. We argue that in order to address these science and research needs, an integrated approach is necessary, one that combines new knowledge with new approaches for knowledge generation, and where research and practice co-evolve; and that such a learning-by-doing approach is essential to rapidly scale up and implement concrete adaptation actions.

  18. The Adaptive Basis of Psychosocial Acceleration: Comment on beyond Mental Health, Life History Strategies Articles

    ERIC Educational Resources Information Center

    Nettle, Daniel; Frankenhuis, Willem E.; Rickard, Ian J.

    2012-01-01

    Four of the articles published in this special section of "Developmental Psychology" build on and refine psychosocial acceleration theory. In this short commentary, we discuss some of the adaptive assumptions of psychosocial acceleration theory that have not received much attention. Psychosocial acceleration theory relies on the behavior of…

  19. An Adaptive Testing Strategy for Mastery Decisions. Research Report 79-5.

    ERIC Educational Resources Information Center

    Kingsbury, G. Gage; Weiss, David J.

    The theory and technology of item characteristic curve (ICC) response theory and adaptive testing were applied to judging individuals' competencies against a prespecified mastery level to determine whether each individual is a "master" or "nonmaster" of a specified content domain. Items from two conventionally administered mastery tests…

  20. Self-Regulation Strategies and Technologies for Adaptive Learning Management Systems for Web-based Instruction

    ERIC Educational Resources Information Center

    Heo, Heeok; Joung, Sunyoung

    2004-01-01

    The current study identifies the potential problems of current web-based instruction and learning management systems in terms of its lack of flexibility and customization required for individual learners? different goals, backgrounds, knowledge levels, and learning capabilities. Advanced adaptive learning management system technologies are able to…

  1. Using Multiple Adaptively-Weighted Strategies for the Resolution of Demonstratives

    DTIC Science & Technology

    1993-05-10

    proper binding for an anaphor . Its main strategies are extended versions of Wilks’ Preference Semantics [46,47) and Sidner’s anaphor resolution rules...different types. The successful chains thus bind one or more anaphors to candidate antecedents. Carter gives the outline of the overall processing...12. Possible Enhancements 87 12.1. Intrasentential Demonstrative References 87 12.2. Anaphoric Pronouns and NPs 87 12.3. Additional Strategies 88 12.4

  2. Exploiting the Interplay between Innate and Adaptive Immunity to Improve Immunotherapeutic Strategies for Epstein-Barr-Virus-Driven Disorders

    PubMed Central

    Martorelli, Debora; Muraro, Elena; Merlo, Anna; Turrini, Riccardo; Faè, Damiana Antonia; Rosato, Antonio; Dolcetti, Riccardo

    2012-01-01

    The recent demonstration that immunotherapeutic approaches may be clinically effective for cancer patients has renewed the interest for this strategy of intervention. In particular, clinical trials using adoptive T-cell therapies disclosed encouraging results, particularly in the context of Epstein-Barr-virus- (EBV-) related tumors. Nevertheless, the rate of complete clinical responses is still limited, thus stimulating the development of more effective therapeutic protocols. Considering the relevance of innate immunity in controlling both infections and cancers, innovative immunotherapeutic approaches should take into account also this compartment to improve clinical efficacy. Evidence accumulated so far indicates that innate immunity effectors, particularly NK cells, can be exploited with therapeutic purposes and new targets have been recently identified. We herein review the complex interactions between EBV and innate immunity and summarize the therapeutic strategies involving both adaptive and innate immune system, in the light of a fruitful integration between these immunotherapeutic modalities for a better control of EBV-driven tumors. PMID:22319542

  3. Plans, Projections and Practitioners: Engaging with Communities to Explore Adaptation Strategies for Transportation Infrastructure

    NASA Astrophysics Data System (ADS)

    Picketts, I. M.

    2015-12-01

    Transportation infrastructure is a significant climate change adaptation concern because it is: costly; designed for long operational lives; susceptible to both episodic and seasonal deterioration; and a significant safety concern. While examples of adaptation exist in transportation design, many communities do not have the capacity to incorporate climate change considerations into infrastructure planning and management. This presentation will overview the process and outcomes of research conducted in collaboration with the communities of Prince George and Squamish, both located in British Columbia (BC), Canada. Previous research in Prince George (in northern BC) involved applying downscaled climate projection information to assess local climate impacts, and identified transportation infrastructure as the top priority for ongoing study. In Prince George the adaptation process was oriented toward determining how the City could plan, design, and maintain roads and other structures to account for climate change. A local steering committee was formed, and created and evaluated 23 potential research topics. Two focus areas were selected for further investigation and explored during a workshop with practitioners, researchers, consultants and other representatives. The workshop precipitated additional modelling of projected impacts of climate change on road maintenance and road safety, and plans to explore the viability of alternative paving techniques. Outcomes of the case study provide insights regarding how researchers can 'combine' top down and bottom up approaches by using modelling information as part of an engagement process with local experts to explore adaptation. Ongoing research in Squamish seeks to apply lessons learned from the Prince George case study (both related to process and the application of modelling information) to a more temperate coastal region with a more climate-concerned population. In Squamish there also lies an opportunity to explicitly focus

  4. Design and Inference for the Intent to Treat Principle using Adaptive Treatment Strategies and Sequential Randomization

    PubMed Central

    Dawson, Ree; Lavori, Philip W.

    2015-01-01

    Nonadherence to assigned treatment jeopardizes the power and interpretability of intent-to-treat comparisons from clinical trial data and continues to be an issue for effectiveness studies, despite their pragmatic emphasis. We posit that new approaches to design need to complement developments in methods for causal inference to address nonadherence, in both experimental and practice settings. This paper considers the conventional study design for psychiatric research and other medical contexts, in which subjects are randomized to treatments that are fixed throughout the trial and presents an alternative that converts the fixed treatments into an adaptive intervention that reflects best practice. The key element is the introduction of an adaptive decision point midway into the study to address a patient's reluctance to remain on treatment before completing a full-length trial of medication. The clinical uncertainty about the appropriate adaptation prompts a second randomization at the new decision point to evaluate relevant options. Additionally, the standard ‘all-or-none’ principal stratification (PS) framework is applied to the first stage of the design to address treatment discontinuation that occurs too early for a mid-trial adaptation. Drawing upon the adaptive intervention features, we develop assumptions to identify the PS causal estimand and introduce restrictions on outcome distributions to simplify Expectation-Maximization calculations. We evaluate the performance of the PS setup, with particular attention to the role played by a binary covariate. The results emphasize the importance of collecting covariate data for use in design and analysis. We consider the generality of our approach beyond the setting of psychiatric research. PMID:25581413

  5. Adaptive Strategies and Person-Environment Fit among Functionally Limited Older Adults Aging in Place: A Mixed Methods Approach

    PubMed Central

    Lien, Laura L.; Steggell, Carmen D.; Iwarsson, Susanne

    2015-01-01

    Older adults prefer to age in place, necessitating a match between person and environment, or person-environment (P-E) fit. In occupational therapy practice, home modifications can support independence, but more knowledge is needed to optimize interventions targeting the housing situation of older adults. In response, this study aimed to explore the accessibility and usability of the home environment to further understand adaptive environmental behaviors. Mixed methods data were collected using objective and perceived indicators of P-E fit among 12 older adults living in community-dwelling housing. Quantitative data described objective P-E fit in terms of accessibility, while qualitative data explored perceived P-E fit in terms of usability. While accessibility problems were prevalent, participants’ perceptions of usability revealed a range of adaptive environmental behaviors employed to meet functional needs. A closer examination of the P-E interaction suggests that objective accessibility does not always stipulate perceived usability, which appears to be malleable with age, self-perception, and functional competency. Findings stress the importance of evaluating both objective and perceived indicators of P-E fit to provide housing interventions that support independence. Further exploration of adaptive processes in older age may serve to deepen our understanding of both P-E fit frameworks and theoretical models of aging well. PMID:26404352

  6. Adaptive Strategies and Person-Environment Fit among Functionally Limited Older Adults Aging in Place: A Mixed Methods Approach.

    PubMed

    Lien, Laura L; Steggell, Carmen D; Iwarsson, Susanne

    2015-09-23

    Older adults prefer to age in place, necessitating a match between person and environment, or person-environment (P-E) fit. In occupational therapy practice, home modifications can support independence, but more knowledge is needed to optimize interventions targeting the housing situation of older adults. In response, this study aimed to explore the accessibility and usability of the home environment to further understand adaptive environmental behaviors. Mixed methods data were collected using objective and perceived indicators of P-E fit among 12 older adults living in community-dwelling housing. Quantitative data described objective P-E fit in terms of accessibility, while qualitative data explored perceived P-E fit in terms of usability. While accessibility problems were prevalent, participants' perceptions of usability revealed a range of adaptive environmental behaviors employed to meet functional needs. A closer examination of the P-E interaction suggests that objective accessibility does not always stipulate perceived usability, which appears to be malleable with age, self-perception, and functional competency. Findings stress the importance of evaluating both objective and perceived indicators of P-E fit to provide housing interventions that support independence. Further exploration of adaptive processes in older age may serve to deepen our understanding of both P-E fit frameworks and theoretical models of aging well.

  7. An Alternative Evacuation Framework to Improve Protective-action Strategies Following a Nuclear Power Accident: The Adaptive Protective Action Zone

    NASA Astrophysics Data System (ADS)

    Hammond, Gregory D.

    Within the U.S. current protective-action strategies to safeguard the public following a nuclear power accident have remained largely unchanged since their implementation in the early 1980s. In the past thirty years, new technologies have been introduced allowing faster computations, better modeling of predicted radiological consequences, and improved accident mapping with geographic information systems (GIS). Utilizing these new technologies, we evaluate the efficacy of alternative strategies, called adaptive protective action zones (APAZs), that use site-specific and event-specific data to dynamically determine evacuation boundaries with simple heuristics in order to better inform protective action decisions (rather than relying on pre-event regulatory bright lines). Several candidate APAZs were developed and then compared to the Nuclear Regulatory Commission's keyhole evacuation strategy (and full evacuation of the emergency planning zone). Two of the APAZs were better on average than existing NRC strategies at reducing either the radiological exposure, the population evacuated, or both. These APAZs are especially effective for larger radioactive plumes and at high population sites; one of them is better at reducing radiation exposure, while the other is better at reducing the population evacuated. However, should policy makers decide that the benefits of APAZs outweigh the costs of implementation, APAZ adoption by U.S. regulatory agencies should be accompanied by a revision to the nuclear-power plant emergency planning basis, and revisions to local nuclear power emergency response planning areas.

  8. Adaptive radiation with regard to nutrient sequestration strategies in the carnivorous plants of the genus Nepenthes.

    PubMed

    Pavlovič, Andrej

    2012-02-01

    Carnivorous pitcher plants of the genus Nepenthes have evolved a great diversity of pitcher morphologies. Selective pressures for maximizing nutrient uptake have driven speciation and diversification of the genus in a process known as adaptive radiation. This leads to the evolution of pitchers adapted to specific and often bizarre source of nutrients, which are not strictly animal-derived. One example is Nepenthes ampullaria with unusual growth pattern and pitcher morphology what enables the plant to capture a leaf litter from the canopy above. We showed that the plant benefits from nitrogen uptake by increased rate of photosynthesis and growth what may provide competitive advantage over others co-habiting plants. A possible impact of such specialization toward hybridization, an important mechanism in speciation, is discussed.

  9. Regional Collaborations to Combat Climate Change: The Climate Science Centers as Strategies for Climate Adaptation

    NASA Astrophysics Data System (ADS)

    Morelli, T. L.; Palmer, R. N.

    2014-12-01

    The Department of Interior Northeast Climate Science Center (NE CSC) is part of a federal network of eight Climate Science Centers created to provide scientific information, tools, and techniques that managers and other parties interested in land, water, wildlife and cultural resources can use to anticipate, monitor, and adapt to climate change. The consortium approach taken by the CSCs allows the academic side of the Centers to gather expertise across departments, disciplines, and even institutions. This interdisciplinary approach is needed for successfully meeting regional needs for climate impact assessment, adaptive management, education, and stakeholder outreach. Partnership with the federal government facilitates interactions with the key on-the-ground stakeholders who are able to operationalize the results and conclusions of that research, monitor the progress of management actions, and provide feedback to refine future methodology and decisions as new information on climate impacts is discovered. For example, NE CSC researchers are analyzing the effect of climate change on the timing and volume of seasonal and annual streamflows and the concomitant effects on ecological and cultural resources; developing techniques to monitor tree range dynamics as affected by natural disturbances which can enable adaptation of projected climate impacts; studying the effects of changes in the frequency and magnitude of drought and stream temperature on brook trout habitats, spatial distribution and population persistence; and conducting assessments of northeastern regional climate projections and high-resolution downscaling. Project methods are being developed in collaboration with stakeholders and results are being shared broadly with federal, state, and other partners to implement and refine effective and adaptive management actions.

  10. Tuning of patient-specific deformable models using an adaptive evolutionary optimization strategy.

    PubMed

    Vidal, Franck P; Villard, Pierre-Frédéric; Lutton, Evelyne

    2012-10-01

    We present and analyze the behavior of an evolutionary algorithm designed to estimate the parameters of a complex organ behavior model. The model is adaptable to account for patient's specificities. The aim is to finely tune the model to be accurately adapted to various real patient datasets. It can then be embedded, for example, in high fidelity simulations of the human physiology. We present here an application focused on respiration modeling. The algorithm is automatic and adaptive. A compound fitness function has been designed to take into account for various quantities that have to be minimized. The algorithm efficiency is experimentally analyzed on several real test cases: 1) three patient datasets have been acquired with the "breath hold" protocol, and 2) two datasets corresponds to 4-D CT scans. Its performance is compared with two traditional methods (downhill simplex and conjugate gradient descent): a random search and a basic real-valued genetic algorithm. The results show that our evolutionary scheme provides more significantly stable and accurate results.

  11. Adaptive Strategies for Controls of Flexible Arms. Ph.D. Thesis

    NASA Technical Reports Server (NTRS)

    Yuan, Bau-San

    1989-01-01

    An adaptive controller for a modern manipulator has been designed based on asymptotical stability via the Lyapunov criterion with the output error between the system and a reference model used as the actuating control signal. Computer simulations were carried out to test the design. The combination of the adaptive controller and a system vibration and mode shape estimator show that the flexible arm should move along a pre-defined trajectory with high-speed motion and fast vibration setting time. An existing computer-controlled prototype two link manipulator, RALF (Robotic Arm, Large Flexible), with a parallel mechanism driven by hydraulic actuators was used to verify the mathematical analysis. The experimental results illustrate that assumed modes found from finite element techniques can be used to derive the equations of motion with acceptable accuracy. The robust adaptive (modal) control is implemented to compensate for unmodelled modes and nonlinearities and is compared with the joint feedback control in additional experiments. Preliminary results show promise for the experimental control algorithm.

  12. Future droughts in Global Climate Models and adaptation strategies from regional present-day analogues

    NASA Astrophysics Data System (ADS)

    Orlowsky, B.; Seneviratne, S. I.

    2012-04-01

    Droughts are among the most impacting phenomena of a changing climate, affecting agricultural productivity and human health. They can furthermore interact with and amplify other climatic extreme events such as heat waves. Our analysis of the CMIP5 ensemble of GCM simulations identifies several hot spots of aggravating droughts in coming decades, such as the Mediterranean, parts of the Southern US and North East Brazil, which also compare well with increasing stress from heat waves. However, as we show by a comparison of drought indices, the exact pattern can substantially depend on the index choice. In some regions of the developing world which are particularly vulnerable to droughts, e.g. Central Africa, this uncertainty is further increased by a high disagreement between the GCMs. In a second step, we perform an analogue search which, for a given target region, identifies regions which under present-day climate show drought conditions that are similar to the projected future drought conditions of the target region. For example, the future conditions in the Mediterranean are found to be analogue to the present-day conditions in parts of the US, Central Asia or Australia. Information from web resources on climate change adaptation and agricultural practices for the identified similar regions are then assessed in the context of the target region as potential guidelines for adaptation. Thus combining the temporal and spatial dimension helps to transfer local climate adaptation knowledge to other regions, where it is expected to become relevant in the future.

  13. Effectuation of adaptive stability and postural alignment strategies are decreased by alcohol intoxication.

    PubMed

    Hafström, A; Modig, F; Magnusson, M; Fransson, P A

    2014-06-01

    Human stability control is a complex process comprising contributions from several partly independent mechanisms such as coordination, feedback and feed-forward control, and adaptation. Acute alcohol intoxication impairs these functions and is recognized as a major contributor to fall traumas. The study aimed to investigate how alcohol intoxication at .06% and .10% blood alcohol concentration (BAC) affected the movement spans and control of posture alignment. The angular positions of the head, shoulder, hip and knees relative to the ankles were measured with a 3D motion analysis system in 25 healthy adults during standing with eyes open or closed and with or without vibratory balance perturbations. Alcohol intoxication significantly increased the movement spans of the head, shoulders, hip and knees in anteroposterior and lateral directions during quiet stance (p < or = .047 and p < or = .003) and balance perturbations (p<.001, both directions). Alcohol intoxication also decreased the ability to reduce the movement spans through adaptation in both anteroposterior (p < or = .011) and lateral (p < or = .004) directions. When sober and submitted to balance perturbations, the subjects aligned the head, shoulders, hip and knees more forward relative to the ankle joint (p < .001), hence adopting a more resilient posture increasing the safety margin for backward falls. Alcohol intoxication significantly delayed this forward realignment (p < or = .022). Alcohol intoxication did not cause any significant posture realignment in the lateral direction. Thus, initiation of adaptive posture realignments to alcohol or other disruptions might be context dependent and associated with reaching a certain level of stability threats.

  14. Adaptive Capacity in Tanzanian Maasailand: Changing strategies to cope with drought in fragmented landscapes

    PubMed Central

    Riosmena, Fernando

    2014-01-01

    This study examines the ways in which the adaptive capacity of households to climatic events varies within communities and is mediated by institutional and landscape changes. We present qualitative and quantitative data from two Maasai communities differentially exposed to the devastating drought of 2009 in Northern Tanzania. We show how rangeland fragmentation combined with the decoupling of institutions and landscapes are affecting pastoralists ability to cope with drought. Our data highlight that mobility remains a key coping mechanism for pastoralists to avoid cattle loss during a drought. However, mobility is now happening in new ways that require not only large amounts of money but new forms of knowledge and connections outside of customary reciprocity networks. Those least affected by the drought, in terms of cattle lost, were those with large herds who were able to sell some of their cattle and to pay for private access to pastures outside of Maasai areas. Drawing on an entitlements framework, we argue that the new coping mechanisms are not available to all, could be making some households more vulnerable to climate change, and reduce the adaptive capacity of the overall system as reciprocity networks and customary institutions are weakened. As such, we posit that adaptive capacity to climate change is uneven within and across communities, is scale-dependent, and is intimately tied to institutional and landscape changes. PMID:25400331

  15. Can Impacts of Climate Change and Agricultural Adaptation Strategies Be Accurately Quantified if Crop Models Are Annually Re-Initialized?

    PubMed

    Basso, Bruno; Hyndman, David W; Kendall, Anthony D; Grace, Peter R; Robertson, G Philip

    2015-01-01

    Estimates of climate change impacts on global food production are generally based on statistical or process-based models. Process-based models can provide robust predictions of agricultural yield responses to changing climate and management. However, applications of these models often suffer from bias due to the common practice of re-initializing soil conditions to the same state for each year of the forecast period. If simulations neglect to include year-to-year changes in initial soil conditions and water content related to agronomic management, adaptation and mitigation strategies designed to maintain stable yields under climate change cannot be properly evaluated. We apply a process-based crop system model that avoids re-initialization bias to demonstrate the importance of simulating both year-to-year and cumulative changes in pre-season soil carbon, nutrient, and water availability. Results are contrasted with simulations using annual re-initialization, and differences are striking. We then demonstrate the potential for the most likely adaptation strategy to offset climate change impacts on yields using continuous simulations through the end of the 21st century. Simulations that annually re-initialize pre-season soil carbon and water contents introduce an inappropriate yield bias that obscures the potential for agricultural management to ameliorate the deleterious effects of rising temperatures and greater rainfall variability.

  16. When climate change is a fact! Adaptive strategies for drinking water production in a changing natural environment.

    PubMed

    Meuleman, A F M; Cirkel, G; Zwolsman, G J J

    2007-01-01

    Climate change increases water system dynamics through temperature changes, changes in precipitation patterns, evaporation, and water quality and water storage in ice packs. Water system dependent economical stakeholders, such as drinking water companies in the Netherlands, have to cope with consequences of climate change, e.g. floods and water shortages in river systems, upcoming of brackish ground water, salt water intrusion, increasing peak demands and microbiological activity due to temperature rise. In the past decades, however, both water systems and drinking water production have become more and more inflexible; water systems have been heavily regulated aiming at maximum security and economic functions and the drinking water supply in the Netherlands has grown into an inflexible, but cheap and reliable, system. At a water catchment scale, flexibility and adaptation are solutions to overcome climate change related consequences. Flexible adaptive strategies for drinking water production comprise new sources for drinking water production, application of storage concepts in the short term, and a redesign of large centralized systems, including flexible treatment plants, in the long term. Transition to flexible concepts will take decades because investment depreciation periods of assets are long. These strategies must be based on thorough knowledge of current assets to seize opportunities for change.

  17. A Framework Approach to Evaluate Cross-Cultural Adaptation of Public Engagement Strategies for Radioactive Waste Management - 13430

    SciTech Connect

    Hermann, Laura

    2013-07-01

    The complex interplay of politics, economics and culture undermines attempts to define universal best practices for public engagement in the management of nuclear materials. In the international context, communicators must rely on careful adaptation and creative execution to make standard communication techniques succeed in their local communities. Nuclear professionals need an approach to assess and adapt culturally specific public engagement strategies to meet the demands of their particular political, economic and social structures. Using participant interviews and public sources, the Potomac Communications Group reviewed country-specific examples of nuclear-related communication efforts to provide insight into a proposed approach. The review considered a spectrum of cultural dimensions related to diversity, authority, conformity, proximity and time. Comparisons help to identify cross-cultural influences of various public engagement tactics and to inform a framework for communicators. While not prescriptive in its application, the framework offers a way for communicators to assess the salience of outreach tactics in specific situations. The approach can guide communicators to evaluate and tailor engagement strategies to achieve localized public outreach goals. (authors)

  18. Stakeholder perspectives on land-use strategies for adapting to climate-change-enhanced coastal hazards: Sarasota, Florida

    USGS Publications Warehouse

    Frazier, Tim G.; Wood, Nathan; Yarnal, Brent

    2010-01-01

    Sustainable land-use planning requires decision makers to balance community growth with resilience to natural hazards. This balance is especially difficult in many coastal communities where planners must grapple with significant growth projections, the persistent threat of extreme events (e.g., hurricanes), and climate-change-driven sea level rise that not only presents a chronic hazard but also alters the spatial extent of sudden-onset hazards such as hurricanes. We examine these stressors on coastal, long-term land-use planning by reporting the results of a one-day community workshop held in Sarasota County, Florida that included focus groups and participatory mapping exercises. Workshop participants reflected various political agendas and socioeconomic interests of five local knowledge domains: business, environment, emergency management and infrastructure, government, and planning. Through a series of alternating domain-specific focus groups and interactive plenary sessions, participants compared the county 2050 comprehensive land-use plan to maps of contemporary hurricane storm-surge hazard zones and projected storm-surge hazard zones enlarged by sea level rise scenarios. This interactive, collaborative approach provided each group of domain experts the opportunity to combine geographically-specific, scientific knowledge on natural hazards and climate change with local viewpoints and concerns. Despite different agendas, interests, and proposed adaptation strategies, there was common agreement among participants for the need to increase community resilience to contemporary hurricane storm-surge hazards and to explore adaptation strategies to combat the projected, enlarged storm-surge hazard zones.

  19. Can Impacts of Climate Change and Agricultural Adaptation Strategies Be Accurately Quantified if Crop Models Are Annually Re-Initialized?

    PubMed Central

    Basso, Bruno; Hyndman, David W.; Kendall, Anthony D.; Grace, Peter R.; Robertson, G. Philip

    2015-01-01

    Estimates of climate change impacts on global food production are generally based on statistical or process-based models. Process-based models can provide robust predictions of agricultural yield responses to changing climate and management. However, applications of these models often suffer from bias due to the common practice of re-initializing soil conditions to the same state for each year of the forecast period. If simulations neglect to include year-to-year changes in initial soil conditions and water content related to agronomic management, adaptation and mitigation strategies designed to maintain stable yields under climate change cannot be properly evaluated. We apply a process-based crop system model that avoids re-initialization bias to demonstrate the importance of simulating both year-to-year and cumulative changes in pre-season soil carbon, nutrient, and water availability. Results are contrasted with simulations using annual re-initialization, and differences are striking. We then demonstrate the potential for the most likely adaptation strategy to offset climate change impacts on yields using continuous simulations through the end of the 21st century. Simulations that annually re-initialize pre-season soil carbon and water contents introduce an inappropriate yield bias that obscures the potential for agricultural management to ameliorate the deleterious effects of rising temperatures and greater rainfall variability. PMID:26043188

  20. Developing and Testing Adaptive Treatment Strategies Using Substance-Induced Psychosis as an Example

    PubMed Central

    Dawson, Ree; Green, Alan I.; Drake, Robert E.; McGlashan, Thomas H.; Schanzer, Bella; Lavori, Philip W.

    2009-01-01

    Decisions concerning treatment changes pervade the management of chronic psychiatric disorders that resist definitive cure, yet empirical evidence for the comparative clinical effectiveness of treatment strategies remains underdeveloped. In this paper we exploit the example of psychosis following substance use to illustrate some new developments in clinical trials design that can provide the most solid evidence base for defining successful strategies. The intent is to explore the strengths and limitations of the methodological approach through a meaningful clinical example, with an emphasis on concepts and issues. Both methodology and clinical science are overviewed. PMID:18779776

  1. Current strategies to create tailored and risk-adapted therapies for CLL patients.

    PubMed

    Cramer, Paula; Eichhorst, Barbara; Reinhardt, Hans Christian; Hallek, Michael

    2016-03-01

    Given the current dynamics in the development of novel agents for CLL therapy, the task to find optimal, non-toxic combinations has become the primary goal. This article gives an update of the most interesting novel drugs. The strategy of the German CLL Study Group to use these agents in combinations is described in detail, highlighting the strategy and first results of a recently started series of phase II combination trials, the BXX series using agents such as bendamustine, idelalisib, ibrutinib, obinutuzumab, ofatumumab and venetoclax.

  2. Developing and testing adaptive treatment strategies using substance-induced psychosis as an example.

    PubMed

    Dawson, Ree; Green, Alan I; Drake, Robert E; McGlashan, Thomas H; Schanzer, Bella; Lavori, Philip W

    2008-01-01

    Decisions concerning treatment changes pervade the management of chronic psychiatric disorders that resist definitive cure, yet empirical evidence for the comparative clinical effectiveness of treatment strategies remains underdeveloped. In this paper we exploit the example of psychosis following substance use to illustrate some new developments in clinical trials design that can provide the most solid evidence base for defining successful strategies. The intent is to explore the strengths and limitations of the methodological approach through a meaningful clinical example, with an emphasis on concepts and issues. Both methodology and clinical science are overviewed.

  3. Developing Coastal Adaptation to Climate Change in the New York City Infrastructure-Shed: Process, Approach, Tools, and Strategies

    NASA Technical Reports Server (NTRS)

    Rosenzweig, Cynthia; Solecki, William D.; Blake, Reginald; Bowman, Malcolm; Faris, Craig; Gornitz, Vivien; Horton, Radley; Jacob, Klaus; LeBlanc, Alice; Leichenko, Robin; Linkin, Megan; Major, David; O'Grady, Megan; Patrick, Lesley; Sussman, Edna; Yohe, Gary; Zimmerman, Rae

    2010-01-01

    While current rates of sea level rise and associated coastal flooding in the New York City region appear to be manageable by stakeholders responsible for communications, energy, transportation, and water infrastructure, projections for sea level rise and associated flooding in the future, especially those associated with rapid icemelt of the Greenland and West Antarctic Icesheets, may be beyond the range of current capacity because an extreme event might cause flooding and inundation beyond the planning and preparedness regimes. This paper describes the comprehensive process, approach, and tools developed by the New York City Panel on Climate Change (NPCC) in conjunction with the region s stakeholders who manage its critical infrastructure, much of which lies near the coast. It presents the adaptation approach and the sea-level rise and storm projections related to coastal risks developed through the stakeholder process. Climate change adaptation planning in New York City is characterized by a multi-jurisdictional stakeholder-scientist process, state-of-the-art scientific projections and mapping, and development of adaptation strategies based on a risk-management approach.

  4. Tradeoff Analysis Between Economic Development and Climate Change Adaptation Strategies for River Nile Basin Water Resources

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Recent Intergovernmental Panel on Climate Change (IPCC) briefings have declared that the growing population in the Nile river basin region (about 160 million, or 57% of the entire population of the basin’s ten riparian countries) is at risk of water scarcity. Adjustment strategies in response to cl...

  5. A Methodology for the Transition from National Strategy to Adaptive Force Packaging

    DTIC Science & Technology

    1994-06-03

    military, economic , political/diplomatic, informational and humanitarian. Examination of the environment of military operations, traditionally termed... economic , political/diplomatic, informational and humanitarian. Examination of the environment of military operations, traditionally termed "battle...development of national strategy requires an appropriate blend of all instruments of power- economic , diplomatic, informational, military and

  6. The Effect of Adaptive, Advisement, and Linear CAI Control Strategies on the Learning of Mathematics Rules.

    ERIC Educational Resources Information Center

    Goetzfried, Leslie; Hannafin, Michael

    This study examined the effects of the locus of three computer assisted instruction (CAI) strategies on the accuracy and efficiency of mathematics rule and application learning of 47 low-achieving seventh grade students in remedial mathematics classes. The instructional task was a mathematics rule lesson concerning divisibility by the numbers two,…

  7. A Rationale and Strategy for Adapting Dialogic Reading for Children with Autism Spectrum Disorder: RECALL

    ERIC Educational Resources Information Center

    Whalon, Kelly; Delano, Monica; Hanline, Mary Frances

    2013-01-01

    As the number of children diagnosed with an autism spectrum disorder (ASD) continues to rise, more children with ASD are accessing early childhood services. Early childhood educators need strategies that benefit a variety of learners served in these settings including those diagnosed with ASD. Shared reading is one routine that is typically used…

  8. Adaptive Flexibility and Maladaptive Routines in Selecting Fast and Frugal Decision Strategies

    ERIC Educational Resources Information Center

    Broder, Arndt; Schiffer, Stefanie

    2006-01-01

    Decision routines unburden the cognitive capacity of the decision maker. In changing environments, however, routines may become maladaptive. In 2 experiments with a hypothetical stock market game (n = 241), the authors tested whether decision routines tend to persist at the level of decision strategies rather than at the level of options in…

  9. Strategies for competitiveness and sustainability: adaptation of a Brazilian subsidiary of a Swedish multinational corporation.

    PubMed

    Santos, Rita; Wennersten, Ronald; Oliva, Eduardo B L; Leal Filho, Walter

    2009-09-01

    The competitiveness, in terms of macro and micro levels of an enterprise, is often dictated by its capacity to innovate, ability to respond to the needs of the market, and resilience to challenges from competition. This paper reviews the literature on the adaptation of research and development (R&D) units in subsidiaries of multinational corporations. It focuses mainly on the impact of the technological dynamic on sustainability performance of the Brazilian subsidiary of the Swedish multinational Ericsson. Through a conceptual framework, it explores information and communication technologies (ICT) towards a transversal and comprehensive vision of levels of innovation and sustainability.

  10. Field Phenotyping Strategies and Breeding for Adaptation of Rice to Drought†

    PubMed Central

    Fischer, Ken S.; Fukai, Shu; Kumar, Arvind; Leung, Hei; Jongdee, Boonrat

    2012-01-01

    This paper is a section of the book “Drought phenotyping in crops: from theory to practice” (Monneveux Philippe and Ribaut Jean-Marcel eds, published by CGIAR Generation Challenge Programme. Texcoco, Mexico). The section describes recent experience in drought phenotyping in rice which is one of the most drought-susceptible crops. The section contains genetic and genomic resources for drought adaptation and methods for selection of drought-resistant varieties in rice. In appendix, there is experience from Thailand on integration of direct selection for grain yield and physiological traits to confer drought resistance. PMID:22934036

  11. Changes in Ecosystem Services and related Livelihoods in the Mekong Delta: vulnerabilities and adaptation strategies

    NASA Astrophysics Data System (ADS)

    Sebesvari, Z.; Renaud, F. G.

    2014-12-01

    The Mekong Delta (Vietnam) is highly vulnerable to the many impacts of global environmental change as well as to the accelerating anthropogenic changes in the catchment and in the delta itself. Today the delta is an agricultural landscape controlled by engineering structures such as channels, dykes, embankments, and sluice gates. These structures have been constructed gradually over the last 200 years mainly for irrigation and flood control in the upper part of the delta and to control saline intrusion in the coastal areas. Recent changes in the hydrology mainly driven by upstream hydropower development on the mainstream and the tributaries of the Mekong will likely have far reaching impacts on the delta´s social-ecological systems through changes in e.g. sedimentation processes, nutrient transport as well as the health of aquatic ecosystems. Further threats to the delta include sea level rise and an increase in seasonal rainfall variability leading to an increase in flood variability. These changes affect the lives of millions of low-income inhabitants who depend on the ecosystem services provided by the Mekong for their livelihoods and sustenance. Since the changes in ecosystem service provision are occurring relatively fast while the resource dependency of the delta population is very high, adaptation becomes a challenge. An assessment of livelihood dependencies on ecosystem services requires an understanding of ecosystem services affected by different drivers of change, as well as of the types of livelihoods likely to be jeopardized as a result of these changes. We will present main ecosystem services supporting specific livelihoods, discuss how they are threatened, and analyse the merits of potential solutions. Options based solely on grey infrastructure might be problematic on the long term while an integration of ecosystem based solution such as a (re)adaptation of agricultural production systems to floods in the upper delta might be a more sustainable

  12. Ribosome profiling reveals an adaptation strategy of reduced bacterium to acute stress.

    PubMed

    Fisunov, Gleb Y; Evsyutina, Daria V; Garanina, Irina A; Arzamasov, Alexander A; Butenko, Ivan O; Altukhov, Ilya A; Nikitina, Anastasia S; Govorun, Vadim M

    2017-01-01

    Bacteria of class Mollicutes (mycoplasmas) feature significant genome reduction which makes them good model organisms for systems biology studies. Previously we demonstrated, that drastic transcriptional response of mycoplasmas to stress results in a very limited response on the level of protein. In this study we used heat stress model of M. gallisepticum and ribosome profiling to elucidate the process of genetic information transfer under stress. We found that under heat stress ribosomes demonstrate selectivity towards mRNA binding. We identified that heat stress response may be divided into two groups on the basis of absolute transcript abundance and fold-change in the translatome. One represents a noise-like response and another is likely an adaptive one. The latter include ClpB chaperone, cell division cluster, homologs of immunoblocking proteins and short ORFs with unknown function. We found that previously identified read-through of terminators contributes to the upregulation of transcripts in the translatome as well. In addition we identified that ribosomes of M. gallisepticum undergo reorganization under the heat stress. The most notable event is decrease of the amount of associated HU protein. In conclusion, only changes of few adaptive transcripts significantly impact translatome, while widespread noise-like transcription plays insignificant role in translation during stress.

  13. The Evolution of Two-Component Systems in Bacteria RevealsDifferent Strategies for Niche Adaptation

    SciTech Connect

    Alm, Eric; Huang, Katherine; Arkin, Adam

    2006-09-13

    Two-component systems including histidine protein kinasesrepresent the primary signal transduction paradigm in prokaryoticorganisms. To understand how these systems adapt to allow organisms todetect niche-specific signals, we analyzed the phylogenetic distributionof nearly 5000 histidine protein kinases from 207 sequenced prokaryoticgenomes. We found that many genomes carry a large repertoire of recentlyevolved signaling genes, which may reflect selective pressure to adapt tonew environmental conditions. Both lineage-specific gene family expansionand horizontal gene transfer play major roles in the introduction of newhistidine kinases into genomes; however, there are differences in howthese two evolutionary forces act. Genes imported via horizontal transferare more likely to retain their original functionality as inferred from asimilar complement of signaling domains, while gene family expansionaccompanied by domain shuffling appears to be a major source of novelgenetic diversity. Family expansion is the dominantsource of newhistidine kinase genes in the genomes most enriched in signalingproteins, and detailed analysis reveals that divergence in domainstructure and changes in expression patterns are hallmarks of recentexpansions. Finally, while these two modes of gene acquisition arewidespread across bacterial taxa, there are clear species-specificpreferences for which mode is used.

  14. Adaptational strategy of a tropical shrub Carissa Carandas L. to urban air pollution.

    PubMed

    Pandey, J; Pandey, U

    1996-12-01

    This paper reports the adaptational response of a tropical shrub Carissa Carandas L. to urban air pollution stress in Varanasi, India. Saplings of C. carandas were grown at a density of one per pot and kept for two years at 25 selected sites in the urban environment. Different sites received different levels of air pollution input. Changes in vegetative growth pattern (leafing and branching), in morphological features and in the distribution of biomass to above and below ground structures were considered in relation to the ambient air quality.Different levels of air pollution input produced different sets of harmful effects. Although the air pollution level at Varanasi reduced the plant height, basal diameter, canopy area, leaf area and total plant biomass of C. carandas, this species retained a major fraction of its photosynthate to above-ground plant parts where foliage assumes predominance. Since carbon gain is dependent not only on the rate of carbon acquisition per unit leaf tissue but also on the amount of photosynthetic tissue present, a shift in relative contribution of photosynthate to leaf production and shoot growth appears to be a pollution-induced adaptive response in C. carandas.

  15. Micro practices of coordination based on complex adaptive systems: user needs and strategies for coordinating public health in Denmark

    PubMed Central

    Wittrup, Inge; Burau, Viola

    2015-01-01

    Introduction Many highly formalised approaches to coordination poorly fit public health and recent studies call for coordination based on complex adaptive systems. Our contribution is two-fold. Empirically, we focus on public health, and theoretically we build on the patient perspective and treat coordination as a process of contingent, two-level negotiations of user needs. Theory and Methods The paper draws on the concept of user needs-based coordination and sees coordination as a process, whereby needs emerging from the life world of the user are made amenable to the health system through negotiations. The analysis is based on an explorative case study of a health promotion initiative in Denmark. It adopts an anthropological qualitative approach and uses a range of qualitative data. Results The analysis identifies four strategies of coordination: the coordinator focusing on the individual user or on relations with other professionals; and the manager coaching the coordinator or providing structural support. Crucially, the coordination strategies by management remain weak as they do not directly relate to specific user needs. Discussion In process of bottom-up negotiations user needs become blurred and this is especially a challenge for management. The study therefore calls for an increased focus on the level nature of negotiations to bridge the gap that currently weakens coordination strategies by management. PMID:26528097

  16. Adaptive and Maladaptive Coping Strategies in Adult Pathological Gamblers and Their Mediating Role with Anxious-Depressive Symptomatology.

    PubMed

    Jauregui, Paula; Onaindia, Jaione; Estévez, Ana

    2017-02-08

    Coping plays a central role in the appearance and persistence of pathological gambling. Anxious and depressive symptomatology also influence pathological gambling and are related to coping. This study aimed to analyze pathological gamblers' coping strategies and styles, as well as associated anxious and depressive symptomatology. The study sample included 167 male pathological gamblers (mean age = 39.29 years) and 107 non-gamblers (mean age = 33.43 years). Measures of gambling, coping, and anxious and depressive symptomatology were used. Results showed that pathological gamblers' scored higher in all the maladaptive coping strategies, problem- and emotion-focused disengagement, and disengagement subscales. These subscales also correlated with pathological gambling, and anxious and depressive symptomatology. Pathological gamblers also scored higher in emotional expression and emotion-focused engagement, with no differences in the rest of the adaptive coping strategies. Coping was also found to predict pathological gambling and anxious and depressive symptomatology. It was found that coping mediated the relationship between pathological gambling and anxious symptomatology when controlling for the effect of age. Specifically, social withdrawal and disengagement stood out as mediators. These results provide practical information for use in clinical settings with people diagnosed with pathological gambling.

  17. Irregular Enemies and the Essence of Strategy: Can the American Way of War Adapt?

    DTIC Science & Technology

    2006-03-01

    consequence was Herman Kahn, On Escalation: Metaphors and Scenarios, New York: Praeger, 1965. 63. Huntington, American Military Strategy, p. 16. 64...sacrifice mandated by a public culture of unpreparedness is well told in Charles E. Heller and William A. Stofft, eds., America’s First Battles, 1776... Herman Hattaway and Archer Jones, How the North Won: A Military History of the Civil War, Urbana, IL: University of Illinois Press, 1983, p. 720, for

  18. Project ADAPT (Report Number 2): Review and Assessment of Post-Orientation Careers of Project Participants. Aerospace Employment Project. Final Report.

    ERIC Educational Resources Information Center

    Massachusetts Inst. of Tech., Cambridge. Dept. of Urban Studies and Planning.

    The careers of 185 previously unemployed aerospace and defense industry professionals are documented, following completion in August 1971 of a 1-month orientation to urban affairs entitled Project ADAPT (Aerospace and Defense Adaptation to Public Technology). Funded by the Labor Department and by the Housing and Urban Development Project to…

  19. Understanding Resilience Dimensions and Adaptive Strategies to the Impact of Recurrent Droughts in Borana Zone, Oromia Region, Ethiopia: A Grounded Theory Approach.

    PubMed

    Birhanu, Zewdie; Ambelu, Argaw; Berhanu, Negalign; Tesfaye, Abraraw; Woldemichael, Kifle

    2017-01-26

    Recurrent shocks and stresses are increasingly deteriorating pastoralist communities' resilience capacities in many aspects. A context specific resilience framework is essential to strengthen pastoralist community's resilience capacity towards the impact of recurrent drought. Hence, the present study was aimed to develop a context specific and data driven resilience building framework towards impacts of recurrent droughts in the case of Borana pastoralists in Ethiopia. Qualitative grounded theory approach was employed to guide the study process. The data were collected through focus group discussions and in-depth interviews in two drought affected districts of Borana Zone during October 2013. The analysis was assisted by ATLAS. ti 7.1.4. The analysis provided a context specific resilience building conceptual tool, which consists of, closely interconnected, eight dimensions operating at multiple capacities and levels: environment (underlying vulnerability factor); livestock, infrastructures/social services, and wealth (immediate causes and effects); community network/social capital, as well as governance, peace and security (support and enabling factors oriented), psychosocial, and human capital (as eventual outcomes and impacts). The resilience capacities of these pastoralist communities have been eroded, leaving them without sufficient and effective adaptive strategies. The emergent resilience framework can serve as a useful guidance to design context-specific interventions that makes the people and the system resilient to the impacts of recurrent droughts.

  20. Understanding Resilience Dimensions and Adaptive Strategies to the Impact of Recurrent Droughts in Borana Zone, Oromia Region, Ethiopia: A Grounded Theory Approach

    PubMed Central

    Birhanu, Zewdie; Ambelu, Argaw; Berhanu, Negalign; Tesfaye, Abraraw; Woldemichael, Kifle

    2017-01-01

    Recurrent shocks and stresses are increasingly deteriorating pastoralist communities’ resilience capacities in many aspects. A context specific resilience framework is essential to strengthen pastoralist community’s resilience capacity towards the impact of recurrent drought. Hence, the present study was aimed to develop a context specific and data driven resilience building framework towards impacts of recurrent droughts in the case of Borana pastoralists in Ethiopia. Qualitative grounded theory approach was employed to guide the study process. The data were collected through focus group discussions and in-depth interviews in two drought affected districts of Borana Zone during October 2013. The analysis was assisted by ATLAS. ti 7.1.4. The analysis provided a context specific resilience building conceptual tool, which consists of, closely interconnected, eight dimensions operating at multiple capacities and levels: environment (underlying vulnerability factor); livestock, infrastructures/social services, and wealth (immediate causes and effects); community network/social capital, as well as governance, peace and security (support and enabling factors oriented), psychosocial, and human capital (as eventual outcomes and impacts). The resilience capacities of these pastoralist communities have been eroded, leaving them without sufficient and effective adaptive strategies. The emergent resilience framework can serve as a useful guidance to design context-specific interventions that makes the people and the system resilient to the impacts of recurrent droughts. PMID:28134771

  1. The impact of aircraft digital weather data in an adaptive observation strategy to improve the ensemble prediction of hurricanes

    NASA Astrophysics Data System (ADS)

    Bensman, Edward Leroy

    Modern meteorological data assimilation techniques and ensemble weather prediction methods involve the minimization of error variance. Both of these techniques are used here to assess the impact of assimilating digital aircraft weather data, in an adaptive observation strategy, to improve hurricane forecasting. Many operational and research centers utilize ensemble prediction systems to improve their weather forecasts. This study utilizes a Monte Carlo technique to randomly generate a series of 50 separate perturbed model states. These ``random'' perturbations are scaled to the typical error values observed daily in meteorology. From the family of 50 ensemble members a field of sea level pressure variance, at the 48-hour forecast point, is calculated using deviations of the 50 members from the control (unperturbed state). The bull's eye of maximum error variance is then backward correlated to various meteorological fields such as temperature, wind and humidity at the 24-hour point of the forecast. The areas of highest correlation represent model sensitivity to random error growth and thus targets for intensive observations. In August and September of 1998, a team of scientists participated in a NASA-sponsored field campaign termed the Third Convection and Moisture Experiment (CAMEX-3). The purpose was to conduct an intensive study of Atlantic hurricanes. The CAMEX-3 data were utilized in this research to assess the impact of targeted observations on subsequent forecasts. Specifically, a series of experiments were conducted utilizing: all of the CAMEX-3 data, a portion just over the model-sensitive target areas, and from a random selection of data throughout the near-storm environment. These data were assimilated using both a multivariate optimal interpolation technique and a 4-dimensional variational assimilation method. Results from these experiments showed that these data, once assimilated into the model's initial state, improved subsequent hurricane forecasts

  2. Climate trends and projections for the Andean Altiplano and strategies for adaptation

    NASA Astrophysics Data System (ADS)

    Valdivia, C.; Thibeault, J.; Gilles, J. L.; García, M.; Seth, A.

    2013-04-01

    Climate variability and change impact production in rainfed agricultural systems of the Bolivian highlands. Maximum temperature trends are increasing for the Altiplano. Minimum temperature increases are significant in the northern region, and decreases are significant in the southern region. Producers' perceptions of climate hazards are high in the central region, while concerns with changing climate and unemployment are high in the north. Similar high-risk perceptions involve pests and diseases in both regions. Altiplano climate projections for end-of-century highlights include increases in temperature, extreme event frequency, change in the timing of rainfall, and reduction of soil humidity. Successful adaptation to these changes will require the development of links between the knowledge systems of producers and scientists. Two-way participatory approaches to develop capacity and information that involve decision makers and scientists are appropriate approaches in this context of increased risk, uncertainty and vulnerability.

  3. A novel photosynthetic strategy for adaptation to low-iron aquatic environments

    USGS Publications Warehouse

    Chauhan, D.; Folea, I.M.; Jolley, C.C.; Kouril, R.; Lubner, C.E.; Lin, S.; Kolber, D.; Wolfe-Simon, Felisa; Golbeck, J.H.; Boekema, E.J.; Fromme, P.

    2011-01-01

    Iron (Fe) availability is a major limiting factor for primary production in aquatic environments. Cyanobacteria respond to Fe deficiency by derepressing the isiAB operon, which encodes the antenna protein IsiA and flavodoxin. At nanomolar Fe concentrations, a PSI-IsiA supercomplex forms, comprising a PSI trimer encircled by two complete IsiA rings. This PSI-IsiA supercomplex is the largest photosynthetic membrane protein complex yet isolated. This study presents a detailed characterization of this complex using transmission electron microscopy and ultrafast fluorescence spectroscopy. Excitation trapping and electron transfer are highly efficient, allowing cyanobacteria to avoid oxidative stress. This mechanism may be a major factor used by cyanobacteria to successfully adapt to modern low-Fe environments. ?? 2010 American Chemical Society.

  4. Biological control of crystal texture: A widespread strategy for adapting crystal properties to function

    SciTech Connect

    Berman, A.; Leiserowitz, L.; Weiner, S.; Addadi, L. ); Hanson, J.; Koetzle, T.F. )

    1993-02-05

    Textures of calcite crystals from a variety of mineralized tissues belong to organisms from four phyla were examined with high-resolution synchrotron x-ray radiation. Significant differences in coherence length and angular spread were observed between taxonomic groups. Crystals from polycrystalline skeletal ensembles were more perfect than those that function as single-crystal elements. Different anistropic effects on crystal texture were observed for sea urchin and mollusk calcite crystals, whereas none was found for the foraminifer, Patellina, and the control calcite crystals. These results show that the manipulation of crystal texture in different organisms is under biological control and that crystal textures in some tissues are adapted to function. A better understanding of this apparently widespread biological phenomenon may provide new insights for improving synthetic crystal-containing materials. 18 refs., 3 figs., 1 tab.

  5. High protein flexibility and reduced hydration water dynamics are key pressure adaptive strategies in prokaryotes

    PubMed Central

    Martinez, N.; Michoud, G.; Cario, A.; Ollivier, J.; Franzetti, B.; Jebbar, M.; Oger, P.; Peters, J.

    2016-01-01

    Water and protein dynamics on a nanometer scale were measured by quasi-elastic neutron scattering in the piezophile archaeon Thermococcus barophilus and the closely related pressure-sensitive Thermococcus kodakarensis, at 0.1 and 40 MPa. We show that cells of the pressure sensitive organism exhibit higher intrinsic stability. Both the hydration water dynamics and the fast protein and lipid dynamics are reduced under pressure. In contrast, the proteome of T. barophilus is more pressure sensitive than that of T. kodakarensis. The diffusion coefficient of hydration water is reduced, while the fast protein and lipid dynamics are slightly enhanced with increasing pressure. These findings show that the coupling between hydration water and cellular constituents might not be simply a master-slave relationship. We propose that the high flexibility of the T. barophilus proteome associated with reduced hydration water may be the keys to the molecular adaptation of the cells to high hydrostatic pressure. PMID:27595789

  6. High protein flexibility and reduced hydration water dynamics are key pressure adaptive strategies in prokaryotes

    NASA Astrophysics Data System (ADS)

    Martinez, N.; Michoud, G.; Cario, A.; Ollivier, J.; Franzetti, B.; Jebbar, M.; Oger, P.; Peters, J.

    2016-09-01

    Water and protein dynamics on a nanometer scale were measured by quasi-elastic neutron scattering in the piezophile archaeon Thermococcus barophilus and the closely related pressure-sensitive Thermococcus kodakarensis, at 0.1 and 40 MPa. We show that cells of the pressure sensitive organism exhibit higher intrinsic stability. Both the hydration water dynamics and the fast protein and lipid dynamics are reduced under pressure. In contrast, the proteome of T. barophilus is more pressure sensitive than that of T. kodakarensis. The diffusion coefficient of hydration water is reduced, while the fast protein and lipid dynamics are slightly enhanced with increasing pressure. These findings show that the coupling between hydration water and cellular constituents might not be simply a master-slave relationship. We propose that the high flexibility of the T. barophilus proteome associated with reduced hydration water may be the keys to the molecular adaptation of the cells to high hydrostatic pressure.

  7. [Night sleep structural alteration as a function of individual strategy of adapting to 520-isolation].

    PubMed

    Zavalko, I M; Boritko, Ya S; Kovrov, G V; Vinokhodova, A G; Chekalina, A I; Smoleevsky, A E

    2014-01-01

    Purpose of the work was to establish a relationship between trends in sleep alteration and individual adaptation to the stress-factors in the 520-day isolation study. Psychological evaluations using a battery of motivation tests and L. Sobchik's modification of the Luscher personality test, and Mirror coordinograph enabled to differentiate groups reacting to the stress on the pattern of "control" (G-1) or "search" (G-2) manifested in individual styles of behavior and operator's activity. The 2 groups showed different dynamics of the night sleep structure. Difficulties with falling asleep in G-1 arose on the eve of "landing onto Mars" and end of the experiment, whereas in G-2 they were evident prior to the end only. Besides, the micro- and segmental sleep structures were more stable in G-1 suggesting the integrity of somnogenic mechanisms despite difficult sleep initiation.

  8. High hydrostatic pressure adaptive strategies in an obligate piezophile Pyrococcus yayanosii

    PubMed Central

    Michoud, Grégoire; Jebbar, Mohamed

    2016-01-01

    Pyrococcus yayanosii CH1, as the first and only obligate piezophilic hyperthermophilic microorganism discovered to date, extends the physical and chemical limits of life on Earth. It was isolated from the Ashadze hydrothermal vent at 4,100 m depth. Multi-omics analyses were performed to study the mechanisms used by the cell to cope with high hydrostatic pressure variations. In silico analyses showed that the P. yayanosii genome is highly adapted to its harsh environment, with a loss of aromatic amino acid biosynthesis pathways and the high constitutive expression of the energy metabolism compared with other non-obligate piezophilic Pyrococcus species. Differential proteomics and transcriptomics analyses identified key hydrostatic pressure-responsive genes involved in translation, chemotaxis, energy metabolism (hydrogenases and formate metabolism) and Clustered Regularly Interspaced Short Palindromic Repeats sequences associated with Cellular apoptosis susceptibility proteins. PMID:27250364

  9. High hydrostatic pressure adaptive strategies in an obligate piezophile Pyrococcus yayanosii

    NASA Astrophysics Data System (ADS)

    Michoud, Grégoire; Jebbar, Mohamed

    2016-06-01

    Pyrococcus yayanosii CH1, as the first and only obligate piezophilic hyperthermophilic microorganism discovered to date, extends the physical and chemical limits of life on Earth. It was isolated from the Ashadze hydrothermal vent at 4,100 m depth. Multi-omics analyses were performed to study the mechanisms used by the cell to cope with high hydrostatic pressure variations. In silico analyses showed that the P. yayanosii genome is highly adapted to its harsh environment, with a loss of aromatic amino acid biosynthesis pathways and the high constitutive expression of the energy metabolism compared with other non-obligate piezophilic Pyrococcus species. Differential proteomics and transcriptomics analyses identified key hydrostatic pressure-responsive genes involved in translation, chemotaxis, energy metabolism (hydrogenases and formate metabolism) and Clustered Regularly Interspaced Short Palindromic Repeats sequences associated with Cellular apoptosis susceptibility proteins.

  10. Moving Past Curricula and Strategies: Language and the Development of Adaptive Pedagogy for Immersive Learning Environments

    NASA Astrophysics Data System (ADS)

    Hand, Brian; Cavagnetto, Andy; Chen, Ying-Chih; Park, Soonhye

    2016-04-01

    Given current concerns internationally about student performance in science and the need to shift how science is being learnt in schools, as a community, we need to shift how we approach the issue of learning and teaching in science. In the future, we are going to have to close the gap between how students construct and engage with knowledge in a media-rich environment, and how school classroom environments engage them. This is going to require a shift to immersive environments where attention is paid to the knowledge bases and resources students bring into the classroom. Teachers will have to adopt adaptive pedagogical approaches that are framed around a more nuanced understanding of epistemological orientation, language and the nature of prosocial environments.

  11. Adapting biomodulatory strategies for treatment in new contexts: pancreatic and oral cancers (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Anbil, Sriram R.; Rizvi, Imran; Khan, Amjad P.; Celli, Jonathan P.; Maytin, Edward V.; Hasan, Tayyaba

    2016-03-01

    Biomodulation of cancer cell metabolism represents a promising approach to overcome tumor heterogeneity and poor selectivity, which contribute significantly to treatment resistance. To date, several studies have demonstrated that modulation of cell metabolism including the heme synthesis pathway serves as an elegant approach to improve the efficacy of aminolevulinic acid (ALA) based photodynamic therapy (PDT). However, the ability of biomodulation-enhanced PDT to improve outcomes in low resource settings and to address challenges in treating lethal tumors with exogenous photosensitizers remains underexplored. The ability of vitamin D or methotrexate to enhance PDT efficacy in a carcinogen-induced hamster cheek pouch model of oral squamous cell carcinoma and in 3D cell-based models for pancreatic ductal adenocarcinoma is evaluated. Challenges associated with adapting PDT regimens to low resource settings, understanding the effects of biomodulatory agents on the metabolism of cancer cells, and the differential effects of biomodulatory agents on tumor and stromal cells will be discussed.

  12. Tumour-adapted Reduction Mammoplasty – a New (Old) Breast Conserving Strategy: Review

    PubMed Central

    Eichbaum, M.; Dietrich, A.; Reinhard, J.; Steinwasser, R.; Eichbaum, C.

    2016-01-01

    Today over 70 % of patients treated for primary breast carcinoma in certified breast centres are managed with breast conserving surgery. The classical semicircular incision directly above the tumour, though in many cases easily carried out and associated with good cosmetic results, does have limitations. Unsatisfactory aesthetic results often occur when tumour location is unfavourable or when there is unfavourable tumour size relative to breast size. Distortion of the nipple, changes to breast shape and retraction of skin overlying surgical defects can occur. Tumour-adapted reduction mammoplasty/mastopexy or the “modified B technique” offer excellent chances of combining the oncological demands of breast surgery with satisfactory symmetrical cosmetic results. This article reviews a traditional, old operative technique that has been re-embraced in various new forms. PMID:26855438

  13. The acquisition of phototrophy: adaptive strategies of hosting endosymbionts and organelles.

    PubMed

    Johnson, Matthew D

    2011-01-01

    Many non-photosynthetic species of protists and metazoans are capable of hosting viable algal endosymbionts or their organelles through adaptations of phagocytic pathways. A form of mixotrophy combining phototrophy and heterotrophy, acquired phototrophy (AcPh) encompasses a suite of endosymbiotic and organelle retention interactions, that range from facultative to obligate. AcPh is a common phenomenon in aquatic ecosystems, with endosymbiotic associations generally more prevalent in nutrient poor environments, and organelle retention typically associated with more productive ones. All AcPhs benefit from enhanced growth due to access to photosynthetic products; however, the degree of metabolic integration and dependency in the host varies widely. AcPh is found in at least four of the major eukaryotic supergroups, and is the driving force in the evolution of secondary and tertiary plastid acquisitions. Mutualistic resource partitioning characterizes most algal endosymbiotic interactions, while organelle retention is a form of predation, characterized by nutrient flow (i.e., growth) in one direction. AcPh involves adaptations to recognize specific prey or endosymbionts and to house organelles or endosymbionts within the endomembrane system but free from digestion. In many cases, hosts depend upon AcPh for the production of essential nutrients, many of which remain obscure. The practice of AcPh has led to multiple independent secondary and tertiary plastid acquisition events among several eukaryote lineages, giving rise to the diverse array of algae found in modern aquatic ecosystems. This article highlights those AcPhs that are model research organisms for both metazoans and protists. Much of the basic biology of AcPhs remains enigmatic, particularly (1) which essential nutrients or factors make certain forms of AcPh obligatory, (2) how hosts regulate and manipulate endosymbionts or sequestered organelles, and (3) what genomic imprint, if any, AcPh leaves on non

  14. Genetic exchange of fimbrial alleles exemplifies the adaptive virulence strategy of Porphyromonas gingivalis.

    PubMed

    Kerr, Jennifer E; Abramian, Jared R; Dao, Doan-Hieu V; Rigney, Todd W; Fritz, Jamie; Pham, Tan; Gay, Isabel; Parthasarathy, Kavitha; Wang, Bing-yan; Zhang, Wenjian; Tribble, Gena D

    2014-01-01

    Porphyromonas gingivalis is a gram-negative anaerobic bacterium, a member of the human oral microbiome, and a proposed "keystone" pathogen in the development of chronic periodontitis, an inflammatory disease of the gingiva. P. gingivalis is a genetically diverse species, and is able to exchange chromosomal DNA between strains by natural competence and conjugation. In this study, we investigate the role of horizontal DNA transfer as an adaptive process to modify behavior, using the major fimbriae as our model system, due to their critical role in mediating interactions with the host environment. We show that P. gingivalis is able to exchange fimbrial allele types I and IV into four distinct strain backgrounds via natural competence. In all recombinants, we detected a complete exchange of the entire fimA allele, and the rate of exchange varies between the different strain backgrounds. In addition, gene exchange within other regions of the fimbrial genetic locus was identified. To measure the biological implications of these allele swaps we compared three genotypes of fimA in an isogenic background, strain ATCC 33277. We demonstrate that exchange of fimbrial allele type results in profound phenotypic changes, including the quantity of fimbriae elaborated, membrane blebbing, auto-aggregation and other virulence-associated phenotypes. Replacement of the type I allele with either the type III or IV allele resulted in increased invasion of gingival fibroblast cells relative to the isogenic parent strain. While genetic variability is known to impact host-microbiome interactions, this is the first study to quantitatively assess the adaptive effect of exchanging genes within the pan genome cloud. This is significant as it presents a potential mechanism by which opportunistic pathogens may acquire the traits necessary to modify host-microbial interactions.

  15. Genetic Exchange of Fimbrial Alleles Exemplifies the Adaptive Virulence Strategy of Porphyromonas gingivalis

    PubMed Central

    Kerr, Jennifer E.; Abramian, Jared R.; Dao, Doan-Hieu V.; Rigney, Todd W.; Fritz, Jamie; Pham, Tan; Gay, Isabel; Parthasarathy, Kavitha; Wang, Bing-yan; Zhang, Wenjian; Tribble, Gena D.

    2014-01-01

    Porphyromonas gingivalis is a gram–negative anaerobic bacterium, a member of the human oral microbiome, and a proposed “keystone” pathogen in the development of chronic periodontitis, an inflammatory disease of the gingiva. P. gingivalis is a genetically diverse species, and is able to exchange chromosomal DNA between strains by natural competence and conjugation. In this study, we investigate the role of horizontal DNA transfer as an adaptive process to modify behavior, using the major fimbriae as our model system, due to their critical role in mediating interactions with the host environment. We show that P. gingivalis is able to exchange fimbrial allele types I and IV into four distinct strain backgrounds via natural competence. In all recombinants, we detected a complete exchange of the entire fimA allele, and the rate of exchange varies between the different strain backgrounds. In addition, gene exchange within other regions of the fimbrial genetic locus was identified. To measure the biological implications of these allele swaps we compared three genotypes of fimA in an isogenic background, strain ATCC 33277. We demonstrate that exchange of fimbrial allele type results in profound phenotypic changes, including the quantity of fimbriae elaborated, membrane blebbing, auto-aggregation and other virulence-associated phenotypes. Replacement of the type I allele with either the type III or IV allele resulted in increased invasion of gingival fibroblast cells relative to the isogenic parent strain. While genetic variability is known to impact host-microbiome interactions, this is the first study to quantitatively assess the adaptive effect of exchanging genes within the pan genome cloud. This is significant as it presents a potential mechanism by which opportunistic pathogens may acquire the traits necessary to modify host-microbial interactions. PMID:24626479

  16. Natural Variation of Arabidopsis Root Architecture Reveals Complementing Adaptive Strategies to Potassium Starvation1[C][W][OA

    PubMed Central

    Kellermeier, Fabian; Chardon, Fabien; Amtmann, Anna

    2013-01-01

    Root architecture is a highly plastic and environmentally responsive trait that enables plants to counteract nutrient scarcities with different foraging strategies. In potassium (K) deficiency (low K), seedlings of the Arabidopsis (Arabidopsis thaliana) reference accession Columbia (Col-0) show a strong reduction of lateral root elongation. To date, it is not clear whether this is a direct consequence of the lack of K as an osmoticum or a triggered response to maintain the growth of other organs under limiting conditions. In this study, we made use of natural variation within Arabidopsis to look for novel root architectural responses to low K. A comprehensive set of 14 differentially responding root parameters were quantified in K-starved and K-replete plants. We identified a phenotypic gradient that links two extreme strategies of morphological adaptation to low K arising from a major tradeoff between main root (MR) and lateral root elongation. Accessions adopting strategy I (e.g. Col-0) maintained MR growth but compromised lateral root elongation, whereas strategy II genotypes (e.g. Catania-1) arrested MR elongation in favor of lateral branching. K resupply and histochemical staining resolved the temporal and spatial patterns of these responses. Quantitative trait locus analysis of K-dependent root architectures within a Col-0 × Catania-1 recombinant inbred line population identified several loci each of which determined a particular subset of root architectural parameters. Our results indicate the existence of genomic hubs in the coordinated control of root growth in stress conditions and provide resources to facilitate the identification of the underlying genes. PMID:23329148

  17. Understanding Inequalities of Maternal Smoking—Bridging the Gap with Adapted Intervention Strategies

    PubMed Central

    Boucher, Julie; Konkle, Anne T. M.

    2016-01-01

    Women who are generally part of socially disadvantaged and economically marginalized groups are especially susceptible to smoking during pregnancy but smoking rates are underreported in both research and interventions. While there is evidence to support the short-term efficacy of nicotine replacement therapy (NRT) use in pregnancy, long-term abstinence rates are modest. Current health strategies and interventions designed to diminish smoking in pregnancy have adopted a simplified approach to maternal smoking—one that suggests that they have a similar degree of choice to non-pregnant smokers regarding the avoidance of risk factors, and overlooks individual predictors of non-adherence. As a result, interventions have been ineffective among this high-risk group. For this reason, this paper addresses the multiple and interacting determinants that must be considered when developing and implementing effective strategies that lead to successful smoking cessation: socioeconomic status (SES), nicotine dependence, social support, culture, mental health, and health services. Based on our review of the literature, we conclude that tailoring cessation programs for pregnant smokers may ultimately optimize NRT efficacy and reduce the prevalence of maternal smoking. PMID:26959037

  18. [Strategies of Adaption, coping reactions and attempts of self-cure in Schizophrenes].

    PubMed

    Lange, H U

    1981-07-01

    Though already Kraepelin started to consider coping behavior, there has not been much interest in it. Besides a summary of the literature, evidence of the study of 616 patient histories and the exploration of 94 schizophrenes is reported. Whereas often speculative interpretations of the patients' behaviour from the sight of the therapists have predominated in publications as yet, here it is preferred - with the danger of listing rationalizations - to outline defense reactions the patients themselves mention. The coping behaviour is classified in groups of symptoms: global strategies, disorders of perception, delusion, disorders of self-awareness, cognitive, affective, and motorial disorders. The discrimination of primary psychotic and "defect" symptoms, however, is often difficult. Some problems of the evaluation of coping behaviour are discussed. Defense reactions are presumably present in all schizophrenic types at least sometimes in the course of the illness. The more abrupt the disease starts, the more inadequate the coping behaviour seems to be. A further investigation of these strategies might be worth while for theoretical und therapeutical reasons.

  19. Coprophagy in wild bonobos (Pan paniscus) at Wamba in the Democratic Republic of the Congo: a possibly adaptive strategy?

    PubMed

    Sakamaki, Tetsuya

    2010-01-01

    Four cases of coprophagy and two cases of fecal inspection were identified during the 1142 h of observing wild bonobos at Wamba in the Luo Scientific Reserve in the Democratic Republic of the Congo. At least 5 females in the study group practiced coprophagy and/or fecal inspection. According to our daily behavioral observations, boredom and stress, insufficient roughage, and the search for essential nutrients could not explain the coprophagy. Several episodes observed in this study indicated that bonobos might have sought and ingested certain valuable food items, such as hard Dialium seeds, in feces during relatively lean seasons. Although coprophagy occurred only rarely among wild bonobos, this practice appeared to represent a possibly adaptive feeding strategy during periods of food scarcity rather than a behavioral abnormality.

  20. Dimorphic tusks and adaptive strategies in a new species of walrus-like dolphin (Odobenocetopsidae) from the Pliocene of Peru

    NASA Astrophysics Data System (ADS)

    de Muizon, Christian; Domning, Daryl P.; Parrish, Mary

    1999-09-01

    Three new specimens of the walrus-like dolphin Odobenocetops from the Pliocene of Peru, shed new light on the anatomy and adaptive strategies of this unique Cetacean. Odobenocetops leptodon nov. sp. is represented by a skull, which bears a 1 35-cm-long needle-like right tusk and a small 25-cm-long left tusk the apex of which was erupted. The long tusk was probably held almost parallel to the axis of the body when swimming. In contrast to O. peruvianus, O. leptodon probably had a small melon and, therefore, echolocation ability, but had reduced (or no) binocular vision. A skull of O. peruvianus with two small tusks similar in size is referred to a female.

  1. Enhancing Artificial Bee Colony Algorithm with Self-Adaptive Searching Strategy and Artificial Immune Network Operators for Global Optimization

    PubMed Central

    Chen, Tinggui; Xiao, Renbin

    2014-01-01

    Artificial bee colony (ABC) algorithm, inspired by the intelligent foraging behavior of honey bees, was proposed by Karaboga. It has been shown to be superior to some conventional intelligent algorithms such as genetic algorithm (GA), artificial colony optimization (ACO), and particle swarm optimization (PSO). However, the ABC still has some limitations. For example, ABC can easily get trapped in the local optimum when handing in functions that have a narrow curving valley, a high eccentric ellipse, or complex multimodal functions. As a result, we proposed an enhanced ABC algorithm called EABC by introducing self-adaptive searching strategy and artificial immune network operators to improve the exploitation and exploration. The simulation results tested on a suite of unimodal or multimodal benchmark functions illustrate that the EABC algorithm outperforms ACO, PSO, and the basic ABC in most of the experiments. PMID:24772023

  2. GestAqua.AdaPT - Mediterranean river basin modeling and reservoir operation strategies for climate change adaptation

    NASA Astrophysics Data System (ADS)

    Alexandre Diogo, Paulo; Nunes, João Pedro; Marco, Machado; Aal, Carlo; Carmona Rodrigues, António; Beça, Pedro; Casanova Lino, Rafael; Rocha, João; Carvalho Santos, Cláudia

    2016-04-01

    Climate change (CC) scenarios for the Mediterranean region include an increase in the frequency and intensity of extreme weather events such as drought periods. higher average temperatures and evapotranspiration, combined with the decrease of annual precipitation may strongly affect the sustainability of water resources. In face of these risks, improving water management actions? by anticipating necessary operational measures is required to insure water quantity and quality according to the needs of the populations and irrigation in agriculture. This is clearly the case of the Alentejo region, southern Portugal, where present climatic conditions already pose significant challenges to water resources stakeholders, mainly from the agricultural and the urban supply sectors. With this in mind, the GestAqua.AdaPT project is underway during 2015 and 2016, aiming at analyzing CC impacts until 2100 and develop operational procedures to ensure water needs are adequately satisfied in the Monte Novo and Vigia reservoirs, which supply water for the city of Évora and nearby irrigation systems. Specific project objectives include: a) defining management and operational adaptation strategies aiming to ensure resource sustainability, both quantitatively and qualitatively; b) evaluate future potential costs and available alternatives to the regional water transfer infrastructure linked with the large Alqueva reservoir implemented in 2011; c) defining CC adaptation strategies to reduce irrigation water needs and d) identification of CC adaptation strategies which can be suitable also to other similar water supply systems. The methodology is centered on the implementation of a cascade of modeling tools, allowing the integrated simulation of the multiple variables under analysis. The project is based on CC scenarios resulting from the CORDEX project for 10 combinations of Global and regional climate models (GCMs and RCMs). The study follows by using two of these combinations

  3. More Water Resources but Less for Irrigation: Adaptation Strategy of the Yellow River in a Changing Environment

    NASA Astrophysics Data System (ADS)

    Tang, Q.; Yin, Y. Y.

    2015-12-01

    The Yellow River is the primary source of freshwater to the northern China. Increasing population and socio-economic development have put great pressure on water resources of the river basin. The anticipated climate and socio-economic changes may further increase water stress. Development of adaptation strategies would have significant implications for water and food security of this region. In this study, the outputs of multiple hydrological models forced with the bias-corrected climatic variables from multiple global climate models were used to assess the change in renewable water resources of the river basin in the 21st century. The outputs of multiple crop models were used to assess the change in agricultural water demand. The domestic and industrial water demands were estimated based on the future socio-economic conditions under the Shared Socio-economic Pathways (SSPs). Besides basic ecosystem needs for water which must be met, the water use in domestic and industrial sectors is considered to have a higher priority than the agricultural water use when water is insufficient. The results show that the renewable water resources of the basin would increase as global mean temperature increases while the water demand would grow much more rapidly, largely due to water demand increase in domestic and industrial sectors. In most of the sub-basins of the Yellow River basin, the available water resources can not sustain all the water use sectors starting from the next a few decades. As more water resources would be appropriated by domestic and industrial sectors, a part of irrigated area had to be converted to rainfed agriculture which led to a large reduction in food production. This study highlights the linked water and food security in a changing environment and suggests that the trade-off should be considered when developing regional adaptation strategies.

  4. Bromo volcano area as human-environment system: interaction of volcanic eruption, local knowledge, risk perception and adaptation strategy

    NASA Astrophysics Data System (ADS)

    Bachri, Syamsul; Stötter, Johann; Sartohadi, Junun

    2013-04-01

    People in the Bromo area (located within Tengger Caldera) have learn to live with the threat of volcanic hazard since this volcano is categorized as an active volcano in Indonesia. During 2010, the eruption intensity increased yielding heavy ash fall and glowing rock fragments. A significant risk is also presented by mass movement which reaches areas up to 25 km from the crater. As a result of the 2010 eruption, 12 houses were destroyed, 25 houses collapsed and there were severe also effects on agriculture and the livestock sector. This paper focuses on understanding the interaction of Bromo volcanic eruption processes and their social responses. The specific aims are to 1) identify the 2010 eruption of Bromo 2) examine the human-volcano relationship within Bromo area in general, and 3) investigate the local knowledge related to hazard, risk perception and their adaptation strategies in specific. In-depth interviews with 33 informants from four districts nearest to the crater included local people and authorities were carried out. The survey focused on farmers, key persons (dukun), students and teachers in order to understand how people respond to Bromo eruption. The results show that the eruption in 2010 was unusual as it took continued for nine months, the longest period in Bromo history. The type of eruption was phreatomagmatic producing material dominated by ash to fine sand. This kind of sediment typically belongs to Tengger mountain eruptions which had produced vast explosions in the past. Furthermore, two years after the eruption, the interviewed people explained that local knowledge and their experiences with volcanic activity do not influence their risk perception. Dealing with this eruption, people in the Bromo area applied 'lumbung desa' (traditional saving systems) and mutual aid activity for surviving the volcanic eruption. Keywords: Human-environment system, local knowledge, risk perception, adaptation strategies, Bromo Volcano Indonesia

  5. The FIGS (Focused Identification of Germplasm Strategy) Approach Identifies Traits Related to Drought Adaptation in Vicia faba Genetic Resources

    PubMed Central

    Khazaei, Hamid; Street, Kenneth; Bari, Abdallah; Mackay, Michael; Stoddard, Frederick L.

    2013-01-01

    Efficient methods to explore plant agro-biodiversity for climate change adaptive traits are urgently required. The focused identification of germplasm strategy (FIGS) is one such approach. FIGS works on the premise that germplasm is likely to reflect the selection pressures of the environment in which it developed. Environmental parameters describing plant germplasm collection sites are used as selection criteria to improve the probability of uncovering useful variation. This study was designed to test the effectiveness of FIGS to search a large faba bean (Vicia faba L.) collection for traits related to drought adaptation. Two sets of faba bean accessions were created, one from moisture-limited environments, and the other from wetter sites. The two sets were grown under well watered conditions and leaf morpho-physiological traits related to plant water use were measured. Machine-learning algorithms split the accessions into two groups based on the evaluation data and the groups created by this process were compared to the original climate-based FIGS sets. The sets defined by trait data were in almost perfect agreement to the FIGS sets, demonstrating that ecotypic differentiation driven by moisture availability has occurred within the faba bean genepool. Leaflet and canopy temperature as well as relative water content contributed more than other traits to the discrimination between sets, indicating that their utility as drought-tolerance selection criteria for faba bean germplasm. This study supports the assertion that FIGS could be an effective tool to enhance the discovery of new genes for abiotic stress adaptation. PMID:23667581

  6. Genomic Expression Analysis Reveals Strategies of Burkholderia cenocepacia to Adapt to Cystic Fibrosis Patients' Airways and Antimicrobial Therapy

    PubMed Central

    Mira, Nuno P.; Madeira, Andreia; Moreira, Ana Sílvia; Coutinho, Carla P.; Sá-Correia, Isabel

    2011-01-01

    Pulmonary colonization of cystic fibrosis (CF) patients with Burkholderia cenocepacia or other bacteria of the Burkholderia cepacia complex (Bcc) is associated with worse prognosis and increased risk of death. During colonization, the bacteria may evolve under the stressing selection pressures exerted in the CF lung, in particular, those resulting from challenges of the host immune defenses, antimicrobial therapy, nutrient availability and oxygen limitation. Understanding the adaptive mechanisms that promote successful colonization and long-term survival of B. cenocepacia in the CF lung is essential for an improved therapeutic outcome of chronic infections. To get mechanistic insights into these adaptive strategies a transcriptomic analysis, based on DNA microarrays, was explored in this study. The genomic expression levels in two clonal variants isolated during long-term colonization of a CF patient who died from the cepacia syndrome were compared. One of the isolates examined, IST439, is the first B. cenocepacia isolate retrieved from the patient and the other isolate, IST4113, was obtained three years later and is more resistant to different classes of antimicrobials. Approximately 1000 genes were found to be differently expressed in the two clonal variants reflecting a marked reprogramming of genomic expression. The up-regulated genes in IST4113 include those involved in translation, iron uptake (in particular, in ornibactin biosynthesis), efflux of drugs and in adhesion to epithelial lung tissue and to mucin. Alterations related with adaptation to the nutritional environment of the CF lung and to an oxygen-limited environment are also suggested to be a key feature of transcriptional reprogramming occurring during long-term colonization, antibiotic therapy and the progression of the disease. PMID:22216120

  7. Molecular diversity of vasotocin-dependent aquaporins closely associated with water adaptation strategy in anuran amphibians.

    PubMed

    Suzuki, M; Tanaka, S

    2010-05-01

    Anuran amphibians represent the first vertebrates that adapted to terrestrial environments, and are successfully distributed around the world, even to forests and arid deserts. Many adult anurans have specialised osmoregulatory organs, in addition to the kidney (i.e. the ventral pelvic skin to absorb water from the external environments and a urinary bladder that stores water and reabsorbs it in times of need). Aquaporin (AQP), a water channel protein, plays a fundamental role in these water absorption/reabsorption processes. The anuran AQP family consists of at least AQP0-AQP5, AQP7-AQP10 and two anuran-specific types, designated as AQPa1 and AQPa2. For the three osmoregulatory organs, AQP3 is constitutively located in the basolateral membrane of the tight-junctioned epithelial cells, allowing water transport between the cytoplasm of these cells and the neighbouring tissue fluid at all times. On the other hand, AQPs at the apical side of the tight epithelial cells are different among these organs, and are named kidney-type AQP2, ventral pelvic skin-type AQPa2 and urinary bladder-type AQPa2. All of them show translocation from the cytoplasmic pool to the apical plasma membrane in response to arginine vasotocin, thereby regulating water transport independently in each osmoregulatory organ. It was further revealed that, in terrestrial and arboreal anurans, the bladder-type AQPa2 is expressed in the pelvic skin, together with the pelvic skin-type AQPa2, potentially facilitating water absorption from the pelvic skin. By contrast, Xenopus has lost the ability to efficiently produce pelvic skin-type AQPa2 (AQP-x3) because Cys-273 of AQP-x3 and/or Cys-273-coding region of AQPx3 mRNA attenuate gene expression at a post-transcriptional step, presumably leading to the prevention of excessive water influx in this aquatic species. Collectively, the acquisition of two forms of AQPa2 and the diversified regulation of their gene expression appears to provide the necessary

  8. Performance adaptive training control strategy for recovering wrist movements in stroke patients: a preliminary, feasibility study

    PubMed Central

    2009-01-01

    Background In the last two decades robot training in neuromotor rehabilitation was mainly focused on shoulder-elbow movements. Few devices were designed and clinically tested for training coordinated movements of the wrist, which are crucial for achieving even the basic level of motor competence that is necessary for carrying out ADLs (activities of daily life). Moreover, most systems of robot therapy use point-to-point reaching movements which tend to emphasize the pathological tendency of stroke patients to break down goal-directed movements into a number of jerky sub-movements. For this reason we designed a wrist robot with a range of motion comparable to that of normal subjects and implemented a self-adapting training protocol for tracking smoothly moving targets in order to facilitate the emergence of smoothness in the motor control patterns and maximize the recovery of the normal RoM (range of motion) of the different DoFs (degrees of Freedom). Methods The IIT-wrist robot is a 3 DoFs light exoskeleton device, with direct-drive of each DoF and a human-like range of motion for Flexion/Extension (FE), Abduction/Adduction (AA) and Pronation/Supination (PS). Subjects were asked to track a variable-frequency oscillating target using only one wrist DoF at time, in such a way to carry out a progressive splinting therapy. The RoM of each DoF was angularly scanned in a staircase-like fashion, from the "easier" to the "more difficult" angular position. An Adaptive Controller evaluated online performance parameters and modulated both the assistance and the difficulty of the task in order to facilitate smoother and more precise motor command patterns. Results Three stroke subjects volunteered to participate in a preliminary test session aimed at verify the acceptability of the device and the feasibility of the designed protocol. All of them were able to perform the required task. The wrist active RoM of motion was evaluated for each patient at the beginning and at the end

  9. Interim decision-making strategies in adaptive designs for population selection using time-to-event endpoints.

    PubMed

    Uozumi, Ryuji; Hamada, Chikuma

    2017-01-01

    Adaptive designs in oncology clinical trials with interim analyses for population selection could be used in the development of targeted therapies if a predefined biomarker hypothesis exists. In this article, we consider an interim analysis using overall survival (OS), progression-free survival (PFS), and both OS and PFS, to determine whether the whole population or only the biomarker-positive population should continue into the subsequent stage of the trial, whereas the final decision is made based on OS data only. In order to increase the probability of selecting the most appropriate population at the interim analysis, we propose an interim decision-making strategy in adaptive designs with correlated endpoints considering the post-progression survival (PPS) magnitudes. In our approach, the interim decision is made on the basis of predictive power by incorporating information on OS as well as PFS to supplement the incomplete OS data. Simulation studies assuming a targeted therapy demonstrated that our interim decision-making procedure performs well in terms of selecting the proper population, especially under a scenario in which PPS affects the correlation between OS and PFS.

  10. Endopolyploidy as a potential alternative adaptive strategy for Arabidopsis leaf size variation in response to UV-B.

    PubMed

    Gegas, Vasilis C; Wargent, Jason J; Pesquet, Edouard; Granqvist, Emma; Paul, Nigel D; Doonan, John H

    2014-06-01

    The extent of endoreduplication in leaf growth is group- or even species-specific, and its adaptive role is still unclear. A survey of Arabidopsis accessions for variation at the level of endopolyploidy, cell number, and cell size in leaves revealed extensive genetic variation in endopolyploidy level. High endopolyploidy is associated with increased leaf size, both in natural and in genetically unstructured (mapping) populations. The underlying genes were identified as quantitative trait loci that control endopolyploidy in nature by modulating the progression of successive endocycles during organ development. This complex genetic architecture indicates an adaptive mechanism that allows differential organ growth over a broad geographic range and under stressful environmental conditions. UV-B radiation was identified as a significant positive climatic predictor for high endopolyploidy. Arabidopsis accessions carrying the increasing alleles for endopolyploidy also have enhanced tolerance to UV-B radiation. UV-absorbing secondary metabolites provide an additional protective strategy in accessions that display low endopolyploidy. Taken together, these results demonstrate that high constitutive endopolyploidy is a significant predictor for organ size in natural populations and is likely to contribute to sustaining plant growth under high incident UV radiation. Endopolyploidy may therefore form part of the range of UV-B tolerance mechanisms that exist in natural populations.

  11. A Bim-targeting strategy overcomes adaptive bortezomib resistance in myeloma through a novel link between autophagy and apoptosis.

    PubMed

    Chen, Shuang; Zhang, Yu; Zhou, Liang; Leng, Yun; Lin, Hui; Kmieciak, Maciej; Pei, Xin-Yan; Jones, Richard; Orlowski, Robert Z; Dai, Yun; Grant, Steven

    2014-10-23

    Bim contributes to resistance to various standard and novel agents. Here we demonstrate that Bim plays a functional role in bortezomib resistance in multiple myeloma (MM) cells and that targeting Bim by combining histone deacetylase inhibitors (HDACIs) with BH3 mimetics (eg, ABT-737) overcomes bortezomib resistance. BH3-only protein profiling revealed high Bim levels (Bim(hi)) in most MM cell lines and primary CD138(+) MM samples. Whereas short hairpin RNA Bim knockdown conferred bortezomib resistance in Bim(hi) cells, adaptive bortezomib-resistant cells displayed marked Bim downregulation. HDACI upregulated Bim and, when combined with ABT-737, which released Bim from Bcl-2/Bcl-xL, potently killed bortezomib-resistant cells. These events were correlated with Bim-associated autophagy attenuation, whereas Bim knockdown sharply increased autophagy in Bim(hi) cells. In Bim(low) cells, autophagy disruption by chloroquine (CQ) was required for HDACI/ABT-737 to induce Bim expression and lethality. CQ also further enhanced HDACI/ABT-737 lethality in bortezomib-resistant cells. Finally, HDACI failed to diminish autophagy or potentiate ABT-737-induced apoptosis in bim(-/-) mouse embryonic fibroblasts. Thus, Bim deficiency represents a novel mechanism of adaptive bortezomib resistance in MM cells, and Bim-targeting strategies combining HDACIs (which upregulate Bim) and BH3 mimetics (which unleash Bim from antiapoptotic proteins) overcomes such resistance, in part by disabling cytoprotective autophagy.

  12. Flood risk and adaptation strategies under climate change and urban expansion: A probabilistic analysis using global data.

    PubMed

    Muis, Sanne; Güneralp, Burak; Jongman, Brenden; Aerts, Jeroen C J H; Ward, Philip J

    2015-12-15

    An accurate understanding of flood risk and its drivers is crucial for effective risk management. Detailed risk projections, including uncertainties, are however rarely available, particularly in developing countries. This paper presents a method that integrates recent advances in global-scale modeling of flood hazard and land change, which enables the probabilistic analysis of future trends in national-scale flood risk. We demonstrate its application to Indonesia. We develop 1000 spatially-explicit projections of urban expansion from 2000 to 2030 that account for uncertainty associated with population and economic growth projections, as well as uncertainty in where urban land change may occur. The projections show that the urban extent increases by 215%-357% (5th and 95th percentiles). Urban expansion is particularly rapid on Java, which accounts for 79% of the national increase. From 2000 to 2030, increases in exposure will elevate flood risk by, on average, 76% and 120% for river and coastal floods. While sea level rise will further increase the exposure-induced trend by 19%-37%, the response of river floods to climate change is highly uncertain. However, as urban expansion is the main driver of future risk, the implementation of adaptation measures is increasingly urgent, regardless of the wide uncertainty in climate projections. Using probabilistic urban projections, we show that spatial planning can be a very effective adaptation strategy. Our study emphasizes that global data can be used successfully for probabilistic risk assessment in data-scarce countries.

  13. Reliable Adaptive Data Aggregation Route Strategy for a Trade-off between Energy and Lifetime in WSNs

    PubMed Central

    Guo, Wenzhong; Hong, Wei; Zhang, Bin; Chen, Yuzhong; Xiong, Naixue

    2014-01-01

    Mobile security is one of the most fundamental problems in Wireless Sensor Networks (WSNs). The data transmission path will be compromised for some disabled nodes. To construct a secure and reliable network, designing an adaptive route strategy which optimizes energy consumption and network lifetime of the aggregation cost is of great importance. In this paper, we address the reliable data aggregation route problem for WSNs. Firstly, to ensure nodes work properly, we propose a data aggregation route algorithm which improves the energy efficiency in the WSN. The construction process achieved through discrete particle swarm optimization (DPSO) saves node energy costs. Then, to balance the network load and establish a reliable network, an adaptive route algorithm with the minimal energy and the maximum lifetime is proposed. Since it is a non-linear constrained multi-objective optimization problem, in this paper we propose a DPSO with the multi-objective fitness function combined with the phenotype sharing function and penalty function to find available routes. Experimental results show that compared with other tree routing algorithms our algorithm can effectively reduce energy consumption and trade off energy consumption and network lifetime. PMID:25215944

  14. Employment Policy and Territories.

    ERIC Educational Resources Information Center

    Berthet, Thierry; Cuntigh, Philippe; Guitton, Christophe

    2002-01-01

    France's employment policy has historically been governed by a strategy of interventions aimed at specific categories of individuals, including victims of industrial restructuring, entry workers, the long-term unemployed, and the disabled. Since the 1980s, France has had the following main lines of employment policy: (1) assistance to victims of…

  15. Cerebellar and Prefrontal Cortex Contributions to Adaptation, Strategies, and Reinforcement Learning

    PubMed Central

    Taylor, Jordan A.; Ivry, Richard B.

    2014-01-01

    Traditionally, motor learning has been studied as an implicit learning process, one in which movement errors are used to improve performance in a continuous, gradual manner. The cerebellum figures prominently in this literature given well-established ideas about the role of this system in error-based learning and the production of automatized skills. Recent developments have brought into focus the relevance of multiple learning mechanisms for sensorimotor learning. These include processes involving repetition, reinforcement learning, and strategy utilization. We examine these developments, considering their implications for understanding cerebellar function and how this structure interacts with other neural systems to support motor learning. Converging lines of evidence from behavioral, computational, and neuropsychological studies suggest a fundamental distinction between processes that use error information to improve action execution or action selection. While the cerebellum is clearly linked to the former, its role in the latter remains an open question. PMID:24916295

  16. Cerebellar and prefrontal cortex contributions to adaptation, strategies, and reinforcement learning.

    PubMed

    Taylor, Jordan A; Ivry, Richard B

    2014-01-01

    Traditionally, motor learning has been studied as an implicit learning process, one in which movement errors are used to improve performance in a continuous, gradual manner. The cerebellum figures prominently in this literature given well-established ideas about the role of this system in error-based learning and the production of automatized skills. Recent developments have brought into focus the relevance of multiple learning mechanisms for sensorimotor learning. These include processes involving repetition, reinforcement learning, and strategy utilization. We examine these developments, considering their implications for understanding cerebellar function and how this structure interacts with other neural systems to support motor learning. Converging lines of evidence from behavioral, computational, and neuropsychological studies suggest a fundamental distinction between processes that use error information to improve action execution or action selection. While the cerebellum is clearly linked to the former, its role in the latter remains an open question.

  17. Adaptive Control for Buck Power Converter Using Fixed Point Inducting Control and Zero Average Dynamics Strategies

    NASA Astrophysics Data System (ADS)

    Hoyos Velasco, Fredy Edimer; García, Nicolás Toro; Garcés Gómez, Yeison Alberto

    In this paper, the output voltage of a buck power converter is controlled by means of a quasi-sliding scheme. The Fixed Point Inducting Control (FPIC) technique is used for the control design, based on the Zero Average Dynamics (ZAD) strategy, including load estimation by means of the Least Mean Squares (LMS) method. The control scheme is tested in a Rapid Control Prototyping (RCP) system based on Digital Signal Processing (DSP) for dSPACE platform. The closed loop system shows adequate performance. The experimental and simulation results match. The main contribution of this paper is to introduce the load estimator by means of LMS, to make ZAD and FPIC control feasible in load variation conditions. In addition, comparison results for controlled buck converter with SMC, PID and ZAD-FPIC control techniques are shown.

  18. Haiti and the Dominican Republic - same island - different climate adaptation strategies

    NASA Astrophysics Data System (ADS)

    Klose, C. D.; Webersik, C.

    2010-12-01

    The two Caribbean states, Haiti and the Dominican Republic, have experienced similar natural forces since the 18th century, such as for instance, hurricanes and earthquakes. Despite this fact, Haiti tends to be more vulnerable to natural forces than the Dominican Republic, while environmental management strategies have been very different in both countries throughout the 19th century. Research findings show that neither atmospheric nor seismic hazards, which directly hit the territory of Haiti, have significant impacts on long-term population densities and growth rates. Conversely, uncontrolled and unregulated urbanization in Haiti between 1850 and 2009 has systematically exposed more people to natural forces. Thus, Haiti is willing to take increasing human security risks, because, it finally matters where people settle. Population growth versus storm occurrence/frequency in different departments/provinces on Hispaniola island between 1850 and 2009.

  19. Imaging of non-Hodgkin lymphomas: diagnosis and response-adapted strategies.

    PubMed

    El-Galaly, Tarec Christoffer; Hutchings, Martin

    2015-01-01

    Optimal lymphoma management requires accurate pretreatment staging and reliable assessment of response, both during and after therapy. Positron emission tomography with computerized tomography (PET/CT) combines functional and anatomical imaging and provides the most sensitive and accurate methods for lymphoma imaging. New guidelines for lymphoma imaging and recently revised criteria for lymphoma staging and response assessment recommend PET/CT staging, treatment monitoring, and response evaluation in all FDG-avid lymphomas, while CT remains the method of choice for non-FDG-avid histologies. Since interim PET imaging has high prognostic value in lymphoma, a number of trials investigate PET-based, response-adapted therapy for non-Hodgkin lymphomas (NHL). PET response is the main determinant of response according to the new response criteria, but PET/CT has little or no role in routine surveillance imaging, the value which is itself questionable. This review presents from a clinical point of view the evidence for the use of imaging and primarily PET/CT in NHL before, during, and after therapy. The reader is given an overview of the current PET-based interventional NHL trials and an insight into possible future developments in the field, including new PET tracers.

  20. Climate change and waterborne diarrhoea in northern India: impacts and adaptation strategies.

    PubMed

    Moors, Eddy; Singh, Tanya; Siderius, Christian; Balakrishnan, Sneha; Mishra, Arabinda

    2013-12-01

    Although several studies show the vulnerability of human health to climate change, a clear comprehensive quantification of the increased health risks attributable to climate change is lacking. Even more complicated are assessments of adaptation measures for this sector. We discuss the impact of climate change on diarrhoea as a representative of a waterborne infectious disease affecting human health in the Ganges basin of northern India. A conceptual framework is presented for climate exposure response relationships based on studies from different countries, as empirical studies and appropriate epidemiological data sets for India are lacking. Four climate variables are included: temperature, increased/extreme precipitation, decreased precipitation/droughts and relative humidity. Applying the conceptual framework to the latest regional climate projections for northern India shows increases between present and future (2040s), varying spatially from no change to an increase of 21% in diarrhoea incidences, with 13.1% increase on average for the Ganges basin. We discuss three types of measures against diarrhoeal disease: reactive actions, preventive actions and national policy options. Preventive actions have the potential to counterbalance this expected increase. However, given the limited progress in reducing incidences over the past decade consorted actions and effective implementation and integration of existing policies are needed.