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Sample records for add parcel select

  1. 77 FR 28409 - Product Change-Parcel Select & Parcel Return Service Negotiated Service Agreement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-14

    ... From the Federal Register Online via the Government Publishing Office POSTAL SERVICE Product Change--Parcel Select & Parcel Return Service Negotiated Service Agreement AGENCY: Postal Service\\TM... Postal Regulatory Commission a Request of the United States Postal Service to Add Parcel Select &...

  2. 77 FR 37078 - Product Change-Parcel Select and Parcel Return Service Negotiated Service Agreement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-20

    ... From the Federal Register Online via the Government Publishing Office POSTAL SERVICE Product Change--Parcel Select and Parcel Return Service Negotiated Service Agreement AGENCY: Postal Service TM... Postal Regulatory Commission a Request of the United States Postal Service to Add Parcel Select &...

  3. 78 FR 63521 - Product Change-Parcel Select & Parcel Return Service Negotiated Service Agreement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-24

    ... From the Federal Register Online via the Government Publishing Office POSTAL SERVICE Product Change--Parcel Select & Parcel Return Service Negotiated Service Agreement AGENCY: Postal Service TM... Parcel Select & Parcel Return Service Contract 5 to Competitive Product List. Documents are available...

  4. 76 FR 16460 - Parcel Select Price and Classification Changes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-23

    ... Parcel Select Price and Classification Changes AGENCY: Postal Regulatory Commission. ACTION: Notice... changes affecting Parcel Select. The Postal Service seeks to implement new prices for Parcel Select for... implement new prices for Parcel Select for forwarding and return to sender. The fee would be the...

  5. 77 FR 42780 - Product Change-Parcel Select Negotiated Service Agreement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-20

    ... From the Federal Register Online via the Government Publishing Office POSTAL SERVICE Product Change--Parcel Select Negotiated Service Agreement AGENCY: Postal Service\\TM\\. ACTION: Notice. SUMMARY... Regulatory Commission a Request of the United States Postal Service to Add Parcel Select Contract 4...

  6. 77 FR 42780 - Product Change-Parcel Select Negotiated Service Agreement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-20

    ... From the Federal Register Online via the Government Publishing Office POSTAL SERVICE Product Change--Parcel Select Negotiated Service Agreement AGENCY: Postal Service TM . ACTION: Notice. SUMMARY... Regulatory Commission a Request of the United States Postal Service to Add Parcel Select Contract 5...

  7. 77 FR 42780 - Product Change-Parcel Select Negotiated Service Agreement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-20

    ... From the Federal Register Online via the Government Publishing Office POSTAL SERVICE Product Change--Parcel Select Negotiated Service Agreement AGENCY: Postal Service\\TM\\. ACTION: Notice. SUMMARY... Regulatory Commission a Request of the United States Postal Service to Add Parcel Select Contract 3...

  8. 77 FR 28410 - Product Change-Parcel Select Negotiated Service Agreement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-14

    ... From the Federal Register Online via the Government Publishing Office POSTAL SERVICE Product Change--Parcel Select Negotiated Service Agreement AGENCY: Postal Service\\TM\\. ACTION: Notice. SUMMARY... Commission a Request of the United States Postal Service to Add Parcel Select Contract 1 to...

  9. 76 FR 2930 - Product Change-Parcel Select Negotiated Service Agreement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-18

    ... From the Federal Register Online via the Government Publishing Office POSTAL SERVICE Product Change--Parcel Select Negotiated Service Agreement AGENCY: Postal Service TM . ACTION: Notice. SUMMARY... ] Commission a Request of the United States Postal Service to Add Parcel Select Contract 1 to...

  10. 78 FR 56248 - Product Change-Parcel Select Negotiated Service Agreement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-12

    ... From the Federal Register Online via the Government Publishing Office POSTAL SERVICE Product Change--Parcel Select Negotiated Service Agreement AGENCY: Postal Service TM . ACTION: Notice. SUMMARY... the Postal Regulatory Commission a Request of the United States Postal Service to Add Parcel...

  11. 77 FR 66193 - Product Change-Parcel Select Negotiated Service Agreement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-02

    ... From the Federal Register Online via the Government Publishing Office POSTAL SERVICE Product Change--Parcel Select Negotiated Service Agreement AGENCY: Postal Service TM . ACTION: Notice. SUMMARY... the Postal Regulatory Commission a Request of the United States Postal Service To Add Parcel...

  12. 76 FR 17784 - Forwarding and Return Service for Parcel Select Mailpieces

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-31

    ... 111 Forwarding and Return Service for Parcel Select Mailpieces AGENCY: Postal Service TM . ACTION... Parcel Select mailpieces and to eliminate the option to request discontinuance of forwarding. The Postal Service also implements a new price for Parcel Select forwards and returns; those pieces will now pay...

  13. Add/Compare/Select Circuit For Rapid Decoding

    NASA Technical Reports Server (NTRS)

    Budinger, James M.; Becker, Neal D.; Johnson, Peter N.

    1993-01-01

    Prototype decoding system operates at 200 Mb/s. ACS (add/compare/select) gate array is highly integrated emitter-coupled-logic circuit implementing arithmetic operations essential to Viterbi decoding of convolutionally encoded data signals. Principal advantage of circuit is speed. Operates as single unit performing eight additions and finds minimum of eight sums, or operates as two independent units, each performing four additions and finding minimum of four sums. Flexibility enables application to variety of different codes. Includes built-in self-testing circuitry, enabling unit to be tested at full speed with help of only simple test fixture.

  14. 76 FR 14284 - Domestic Shipping Services Product Launch of Parcel Select Regional Ground

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-16

    .... Enter a minimum of 200 pieces or 50 pounds of mail for each mailing. Use the Electronic Verification... (electronic option only), insurance, and Hold For Pickup service. Markings and Mail Preparation The basic...); Standard Mail prepared as Not Flat-Machinable pieces or as machinable or irregular parcels...

  15. Using tax parcels to select a location-based sample: an illustration that examines residents' awareness of sex offenders in neighborhoods.

    PubMed

    Craun, Sarah W; Freisthler, Bridget

    2008-08-01

    Social science research is increasingly considering place when examining social programs and policies with a spatial component. A specific research challenge involving spatial policies is how to select a sample of individuals based on their geographic locations. This article illustrates the use of geographic information systems, tax parcels, and mail surveys to target residents in varied geographic areas. A provided example demonstrates how researchers obtained a sample of respondents living within one tenth of a mile of multiple registered sex offenders. The challenges of using tax parcels to obtain addresses for apartments and mobile home parks are also explored.

  16. Using Tax Parcels to Select a Location-Based Sample: An Illustration that Examines Residents' Awareness of Sex Offenders in Neighborhoods

    ERIC Educational Resources Information Center

    Craun, Sarah W.; Freisthler, Bridget

    2008-01-01

    Social science research is increasingly considering place when examining social programs and policies with a spatial component. A specific research challenge involving spatial policies is how to select a sample of individuals based on their geographic locations. This article illustrates the use of geographic information systems, tax parcels, and…

  17. Space station systems technology study (add-on task). Volume 2: Trade study and technology selection

    NASA Technical Reports Server (NTRS)

    1985-01-01

    The current Space Station Systems Technology Study add on task was an outgrowth of the Advanced Platform Systems Technology Study (APSTS) that was completed in April 1983 and the subsequent Space Station System Technology Study completed in April 1984. The first APSTS proceeded from the identification of 106 technology topics to the selection of five for detailed trade studies. During the advanced platform study, the technical issues and options were evaluated through detailed trade processes, individual consideration was given to costs and benefits for the technologies identified for advancement, and advancement plans were developed. An approach similar to that was used in the subsequent study, with emphasis on system definition in four specific technology areas to facilitate a more in depth analysis of technology issues.

  18. Volumetric and Correlational Implications of Brain Parcellation Method Selection: A 3-Way Comparison in the Frontal Lobes

    PubMed Central

    Cox, Simon R.; McKenzie, Tahlia I.; Aribisala, Benjamin S.; Royle, Natalie A.; MacPherson, Sarah E.; MacLullich, Alasdair M.J.; Bastin, Mark E.; Wardlaw, Joanna M.; Deary, Ian J.; Ferguson, Karen J.

    2016-01-01

    Objective The aims of this study were to compare distinct brain frontal lobe parcellation methods across 90 brain magnetic resonance imaging scans and examine their associations with cognition in older age. Methods Three parcellation methods (Manual, FreeSurfer, and Stereology) were applied to T1-weighted magnetic resonance imaging of 90 older men, aged ∼73 years. A measure of general fluid intelligence (gf) associated with dorsolateral frontal regions was also derived from a contemporaneous psychological test battery. Results Despite highly discordant raw volumes for the same nominal regions, Manual and FreeSurfer (but not Stereology) left dorsolateral measures were significantly correlated with gf (r > 0.22), whereas orbital and inferior lateral volumes were not, consistent with the hypothesized frontal localization of gf. Conclusions Individual differences in specific frontal lobe brain volumes—variously measured—show consistent associations with cognitive ability in older age. Importantly, differences in parcellation protocol for some regions that may impact the outcome of brain-cognition analyses are discussed. PMID:26466114

  19. Cognitive Control and Attentional Selection in Adolescents with ADHD versus ADD

    ERIC Educational Resources Information Center

    Carr, Laurie; Henderson, John; Nigg, Joel T.

    2010-01-01

    An important research question is whether Attention Deficit Hyperactivity Disorder (ADHD) is related to early- or late-stage attentional control mechanisms and whether this differentiates a nonhyperactive subtype (ADD). This question was addressed in a sample of 145 ADD/ADHD and typically developing comparison adolescents (aged 13-17). Attentional…

  20. Sensitivity analysis of add-on price estimate for select silicon wafering technologies

    NASA Technical Reports Server (NTRS)

    Mokashi, A. R.

    1982-01-01

    The cost of producing wafers from silicon ingots is a major component of the add-on price of silicon sheet. Economic analyses of the add-on price estimates and their sensitivity internal-diameter (ID) sawing, multiblade slurry (MBS) sawing and fixed-abrasive slicing technique (FAST) are presented. Interim price estimation guidelines (IPEG) are used for estimating a process add-on price. Sensitivity analysis of price is performed with respect to cost parameters such as equipment, space, direct labor, materials (blade life) and utilities, and the production parameters such as slicing rate, slices per centimeter and process yield, using a computer program specifically developed to do sensitivity analysis with IPEG. The results aid in identifying the important cost parameters and assist in deciding the direction of technology development efforts.

  1. Not one extrastriate body area: Using anatomical landmarks, hMT+, and visual field maps to parcellate limb-selective activations in human lateral occipitotemporal cortex

    PubMed Central

    Weiner, Kevin S.; Grill-Spector, Kalanit

    2011-01-01

    The prevailing view of human lateral occipitotemporal cortex (LOTC) organization suggests a single area selective for images of the human body (extrastriate body area, EBA) that highly overlaps with the human motion-selective complex (hMT+). Using functional magnetic resonance imaging with higher resolution (1.5mm voxels) than past studies (3–4mm voxels), we examined the fine-scale spatial organization of these activations relative to each other, as well as to visual field maps in LOTC. Rather than one contiguous EBA highly overlapping hMT+, results indicate three limb-selective activations organized in a crescent surrounding hMT+: (1) an activation posterior to hMT+ on the lateral occipital sulcus/middle occipital gyrus (LOS/MOG) overlapping the lower vertical meridian shared between visual field maps LO-2 and TO-1, (2) an activation anterior to hMT+ on the middle temporal gyrus (MTG) consistently overlapping the lower vertical meridian of TO-2 and extending outside presently defined visual field maps, and (3) an activation inferior to hMT+ on the inferotemporal gyrus (ITG) overlapping the parafoveal representation of the TO cluster. This crescent organization of limb-selective activations surrounding hMT+ is reproducible over a span of three years and is consistent across different image types used for localization. Further, these regions exhibit differential position properties: preference for contralateral image presentation decreases and preference for foveal presentation increases from the limb-selective LOS to the MTG. Finally, the relationship between limb-selective activations and visual field maps extends to the dorsal stream where a posterior IPS activation overlaps V7. Overall, our measurements demonstrate a series of LOTC limb-selective activations that 1) have separate anatomical and functional boundaries, 2) overlap distinct visual field maps, and 3) illustrate differential position properties. These findings indicate that category selectivity

  2. Gyral parcellation of cortical surfaces via coupled flow field tracking

    NASA Astrophysics Data System (ADS)

    Li, Gang; Guo, Lei; Li, Kaiming; Nie, Jingxin; Liu, Tianming

    2010-03-01

    This paper presents a novel method for parcellation of the cortical surface of human brain into gyral based regions via coupled flow field tracking. The proposed method consists of two major steps. First, the cortical surface is automatically parcellated into sulcal based regions using several procedures: estimating principal curvatures and principal directions; applying the hidden Markov random field and the Expectation-Maximization (HMRF-EM) framework for sulcal region segmentation based on the maximum principal curvature; diffusing the maximum principal direction field in order to propagate reliable and informative principal directions at gyral crests and sulcal bottoms to other flat cortical regions with noisy principal directions by minimization of an energy function; tracking the flow field towards sulcal bottoms to parcellate the cortical surfaces into sulcal basins. The sulcal parcellation provides a very good initialization for the following steps of gyral parcellation on cortical surfaces. Second, based on the sulcal parcellation results, the cortical surface is further parcellated into gyral based regions using the following procedures: extracting gyral crest segments; dilating gyral crest segments; inverting the principal direction flow field and tracking the flow field towards gyral crests in order to partition the cortical surface into a collection of gyral patches; merging gyral patches to obtain gyral parcellation of the cortical surface. The proposed algorithm pipeline is applied to nine randomly selected cortical surfaces of normal brains and promising results are obtained. The accuracy of the semi-automatic gyral parcellation is comparable to that labeled manually by experts.

  3. Kinetics of Reactive Modules Adds Discriminative Dimensions for Selective Cell Imaging.

    PubMed

    Quérard, Jérôme; Le Saux, Thomas; Gautier, Arnaud; Alcor, Damien; Croquette, Vincent; Lemarchand, Annie; Gosse, Charlie; Jullien, Ludovic

    2016-05-18

    Living cells are chemical mixtures of exceptional interest and significance, whose investigation requires the development of powerful analytical tools fulfilling the demanding constraints resulting from their singular features. In particular, multiplexed observation of a large number of molecular targets with high spatiotemporal resolution appears highly desirable. One attractive road to address this analytical challenge relies on engaging the targets in reactions and exploiting the rich kinetic signature of the resulting reactive module, which originates from its topology and its rate constants. This review explores the various facets of this promising strategy. We first emphasize the singularity of the content of a living cell as a chemical mixture and suggest that its multiplexed observation is significant and timely. Then, we show that exploiting the kinetics of analytical processes is relevant to selectively detect a given analyte: upon perturbing the system, the kinetic window associated to response read-out has to be matched with that of the targeted reactive module. Eventually, we introduce the state-of-the-art of cell imaging exploiting protocols based on reaction kinetics and draw some promising perspectives. PMID:26833808

  4. Kinetics of Reactive Modules Adds Discriminative Dimensions for Selective Cell Imaging.

    PubMed

    Quérard, Jérôme; Le Saux, Thomas; Gautier, Arnaud; Alcor, Damien; Croquette, Vincent; Lemarchand, Annie; Gosse, Charlie; Jullien, Ludovic

    2016-05-18

    Living cells are chemical mixtures of exceptional interest and significance, whose investigation requires the development of powerful analytical tools fulfilling the demanding constraints resulting from their singular features. In particular, multiplexed observation of a large number of molecular targets with high spatiotemporal resolution appears highly desirable. One attractive road to address this analytical challenge relies on engaging the targets in reactions and exploiting the rich kinetic signature of the resulting reactive module, which originates from its topology and its rate constants. This review explores the various facets of this promising strategy. We first emphasize the singularity of the content of a living cell as a chemical mixture and suggest that its multiplexed observation is significant and timely. Then, we show that exploiting the kinetics of analytical processes is relevant to selectively detect a given analyte: upon perturbing the system, the kinetic window associated to response read-out has to be matched with that of the targeted reactive module. Eventually, we introduce the state-of-the-art of cell imaging exploiting protocols based on reaction kinetics and draw some promising perspectives.

  5. Unsupervised fetal cortical surface parcellation

    NASA Astrophysics Data System (ADS)

    Dahdouh, Sonia; Limperopoulos, Catherine

    2016-03-01

    At the core of many neuro-imaging studies, atlas-based brain parcellations are used for example to study normal brain evolution across the lifespan. These atlases rely on the assumption that the same anatomical features are present on all subjects to be studied and that these features are stable enough to allow meaningful comparisons between different brain surfaces and structures These methods, however, often fail when applied to fetal MRI data, due to the lack of consistent anatomical features present across gestation. This paper presents a novel surface-based fetal cortical parcellation framework which attempts to circumvent the lack of consistent anatomical features by proposing a brain parcellation scheme that is based solely on learned geometrical features. A mesh signature incorporating both extrinsic and intrinsic geometrical features is proposed and used in a clustering scheme to define a parcellation of the fetal brain. This parcellation is then learned using a Random Forest (RF) based learning approach and then further refined in an alpha-expansion graph-cut scheme. Based on the votes obtained by the RF inference procedure, a probability map is computed and used as a data term in the graph-cut procedure. The smoothness term is defined by learning a transition matrix based on the dihedral angles of the faces. Qualitative and quantitative results on a cohort of both healthy and high-risk fetuses are presented. Both visual and quantitative assessments show good results demonstrating a reliable method for fetal brain data and the possibility of obtaining a parcellation of the fetal cortical surfaces using only geometrical features.

  6. Parcellating connectivity in spatial maps.

    PubMed

    Baldassano, Christopher; Beck, Diane M; Fei-Fei, Li

    2015-01-01

    A common goal in biological sciences is to model a complex web of connections using a small number of interacting units. We present a general approach for dividing up elements in a spatial map based on their connectivity properties, allowing for the discovery of local regions underlying large-scale connectivity matrices. Our method is specifically designed to respect spatial layout and identify locally-connected clusters, corresponding to plausible coherent units such as strings of adjacent DNA base pairs, subregions of the brain, animal communities, or geographic ecosystems. Instead of using approximate greedy clustering, our nonparametric Bayesian model infers a precise parcellation using collapsed Gibbs sampling. We utilize an infinite clustering prior that intrinsically incorporates spatial constraints, allowing the model to search directly in the space of spatially-coherent parcellations. After showing results on synthetic datasets, we apply our method to both functional and structural connectivity data from the human brain. We find that our parcellation is substantially more effective than previous approaches at summarizing the brain's connectivity structure using a small number of clusters, produces better generalization to individual subject data, and reveals functional parcels related to known retinotopic maps in visual cortex. Additionally, we demonstrate the generality of our method by applying the same model to human migration data within the United States. This analysis reveals that migration behavior is generally influenced by state borders, but also identifies regional communities which cut across state lines. Our parcellation approach has a wide range of potential applications in understanding the spatial structure of complex biological networks.

  7. Earthquake Hazard Class Mapping by Parcel in Las Vegas Valley

    NASA Astrophysics Data System (ADS)

    Pancha, A.; Pullammanappallil, S.; Louie, J. N.; Hellmer, W. K.

    2011-12-01

    Clark County, Nevada completed the very first effort in the United States to map earthquake hazard class systematically through an entire urban area. The map is used in development and disaster response planning, in addition to its direct use for building code implementation and enforcement. The County contracted with the Nevada System of Higher Education to classify about 500 square miles including urban Las Vegas Valley, and exurban areas considered for future development. The Parcel Map includes over 10,000 surface-wave array measurements accomplished over three years using Optim's SeisOpt° ReMi measurement and processing techniques adapted for large scale data. These array measurements classify individual parcels on the NEHRP hazard scale. Parallel "blind" tests were conducted at 93 randomly selected sites. The rms difference between the Vs30 values yielded by the blind data and analyses and the Parcel Map analyses is 4.92%. Only six of the blind-test sites showed a difference with a magnitude greater than 10%. We describe a "C+" Class for sites with Class B average velocities but soft surface soil. The measured Parcel Map shows a clearly definable C+ to C boundary on the west side of the Valley. The C to D boundary is much more complex. Using the parcel map in computing shaking in the Valley for scenario earthquakes is crucial for obtaining realistic predictions of ground motions.

  8. 76 FR 11297 - New Regional Ground Service for Parcels

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-01

    ...: The Commission is noticing a recently-filed Postal Service notice of rate and classification changes affecting Parcel Select. The changes involve a new offering identified as Regional Ground service. This notice informs the public of the filing, addresses preliminary procedural matters, and invites...

  9. Hydraulic Hybrid and Conventional Parcel Delivery Vehicles' Measured Laboratory Fuel Economy on Targeted Drive Cycles

    SciTech Connect

    Lammert, M. P.; Burton, J.; Sindler, P.; Duran, A.

    2014-10-01

    This research project compares laboratory-measured fuel economy of a medium-duty diesel powered hydraulic hybrid vehicle drivetrain to both a conventional diesel drivetrain and a conventional gasoline drivetrain in a typical commercial parcel delivery application. Vehicles in this study included a model year 2012 Freightliner P100H hybrid compared to a 2012 conventional gasoline P100 and a 2012 conventional diesel parcel delivery van of similar specifications. Drive cycle analysis of 484 days of hybrid parcel delivery van commercial operation from multiple vehicles was used to select three standard laboratory drive cycles as well as to create a custom representative cycle. These four cycles encompass and bracket the range of real world in-use data observed in Baltimore United Parcel Service operations. The NY Composite cycle, the City Suburban Heavy Vehicle Cycle cycle, and the California Air Resources Board Heavy Heavy-Duty Diesel Truck (HHDDT) cycle as well as a custom Baltimore parcel delivery cycle were tested at the National Renewable Energy Laboratory's Renewable Fuels and Lubricants Laboratory. Fuel consumption was measured and analyzed for all three vehicles. Vehicle laboratory results are compared on the basis of fuel economy. The hydraulic hybrid parcel delivery van demonstrated 19%-52% better fuel economy than the conventional diesel parcel delivery van and 30%-56% better fuel economy than the conventional gasoline parcel delivery van on cycles other than the highway-oriented HHDDT cycle.

  10. MarsAtlas: A cortical parcellation atlas for functional mapping.

    PubMed

    Auzias, Guillaume; Coulon, Olivier; Brovelli, Andrea

    2016-04-01

    An open question in neuroimaging is how to develop anatomical brain atlases for the analysis of functional data. Here, we present a cortical parcellation model based on macroanatomical information and test its validity on visuomotor-related cortical functional networks. The parcellation model is based on a recently developed cortical parameterization method (Auzias et al., [2013]: IEEE Trans Med Imaging 32:873-887), called HIP-HOP. This method exploits a set of primary and secondary sulci to create an orthogonal coordinate system on the cortical surface. A natural parcellation scheme arises from the axes of the HIP-HOP model running along the fundus of selected sulci. The resulting parcellation scheme, called MarsAtlas, complies with dorsoventral/rostrocaudal direction fields and allows inter-subject matching. To test it for functional mapping, we analyzed a MEG dataset collected from human participants performing an arbitrary visuomotor mapping task. Single-trial high-gamma activity, HGA (60-120 Hz), was estimated using spectral analysis and beamforming techniques at cortical areas arising from a Talairach atlas (i.e., Brodmann areas) and MarsAtlas. Using both atlases, we confirmed that visuomotor associations involve an increase in HGA over the sensorimotor and fronto-parietal network, in addition to medial prefrontal areas. However, MarsAtlas provided: (1) crucial functional information along both the dorsolateral and rostrocaudal direction; (2) an increase in statistical significance. To conclude, our results suggest that the MarsAtlas is a valid anatomical atlas for functional mapping, and represents a potential anatomical framework for integration of functional data arising from multiple techniques such as MEG, intracranial EEG and fMRI. PMID:26813563

  11. Model-Based Analysis of Electric Drive Options for Medium-Duty Parcel Delivery Vehicles: Preprint

    SciTech Connect

    Barnitt, R. A.; Brooker, A. D.; Ramroth, L.

    2010-12-01

    Medium-duty vehicles are used in a broad array of fleet applications, including parcel delivery. These vehicles are excellent candidates for electric drive applications due to their transient-intensive duty cycles, operation in densely populated areas, and relatively high fuel consumption and emissions. The National Renewable Energy Laboratory (NREL) conducted a robust assessment of parcel delivery routes and completed a model-based techno-economic analysis of hybrid electric vehicle (HEV) and plug-in hybrid electric vehicle configurations. First, NREL characterized parcel delivery vehicle usage patterns, most notably daily distance driven and drive cycle intensity. Second, drive-cycle analysis results framed the selection of drive cycles used to test a parcel delivery HEV on a chassis dynamometer. Next, measured fuel consumption results were used to validate simulated fuel consumption values derived from a dynamic model of the parcel delivery vehicle. Finally, NREL swept a matrix of 120 component size, usage, and cost combinations to assess impacts on fuel consumption and vehicle cost. The results illustrated the dependency of component sizing on drive-cycle intensity and daily distance driven and may allow parcel delivery fleets to match the most appropriate electric drive vehicle to their fleet usage profile.

  12. Optimal combination of multiple cortical surface parcellations

    NASA Astrophysics Data System (ADS)

    Hu, Xintao; Guo, Lei; Li, Gang; Li, Kaiming; Liu, Tianming

    2010-03-01

    A variety of methodologies have been developed for the parcellation of human cortical surface into sulcal or gyral regions due to its importance in structural and functional mapping of the human brain. However, characterizing the performance of surface parcellation methods and the estimation of ground truth of segmentation are still open problems. In this paper, we present an algorithm for simultaneous truth and performance estimation of various approaches for human cortical surface parcellation. The probabilistic true segmentation is estimated as a weighted combination of the segmentations resulted from multiple methods. Afterward, an Expectation-Maximization (EM) algorithm is used to optimize the weighting depending on the estimated performance level of each method. Furthermore, a spatial homogeneity constraint modeled by the Hidden Markov Random Field (HMRF) theory is incorporated to refine the estimated true segmentation into a spatially homogenous decision. The proposed method has been evaluated using both synthetic and real data. The experimental results demonstrate the validity of the method proposed in this paper. Also, it has been used to generate reference sulci regions to perform a comparison study of three methods for cortical surface parcellation.

  13. Mathematical Model of Evolution of Brain Parcellation.

    PubMed

    Ferrante, Daniel D; Wei, Yi; Koulakov, Alexei A

    2016-01-01

    We study the distribution of brain and cortical area sizes [parcellation units (PUs)] obtained for three species: mouse, macaque, and human. We find that the distribution of PU sizes is close to lognormal. We propose the mathematical model of evolution of brain parcellation based on iterative fragmentation and specialization. In this model, each existing PU has a probability to be split that depends on PU size only. This model suggests that the same evolutionary process may have led to brain parcellation in these three species. Within our model, region-to-region (macro) connectivity is given by the outer product form. We show that most experimental data on non-zero macaque cortex macroscopic-level connections can be explained by the outer product power-law form suggested by our model (62% for area V1). We propose a multiplicative Hebbian learning rule for the macroconnectome that could yield the correct scaling of connection strengths between areas. We thus propose an evolutionary model that may have contributed to both brain parcellation and mesoscopic level connectivity in mammals. PMID:27378859

  14. Mathematical Model of Evolution of Brain Parcellation

    PubMed Central

    Ferrante, Daniel D.; Wei, Yi; Koulakov, Alexei A.

    2016-01-01

    We study the distribution of brain and cortical area sizes [parcellation units (PUs)] obtained for three species: mouse, macaque, and human. We find that the distribution of PU sizes is close to lognormal. We propose the mathematical model of evolution of brain parcellation based on iterative fragmentation and specialization. In this model, each existing PU has a probability to be split that depends on PU size only. This model suggests that the same evolutionary process may have led to brain parcellation in these three species. Within our model, region-to-region (macro) connectivity is given by the outer product form. We show that most experimental data on non-zero macaque cortex macroscopic-level connections can be explained by the outer product power-law form suggested by our model (62% for area V1). We propose a multiplicative Hebbian learning rule for the macroconnectome that could yield the correct scaling of connection strengths between areas. We thus propose an evolutionary model that may have contributed to both brain parcellation and mesoscopic level connectivity in mammals. PMID:27378859

  15. Cirrus Parcel Model Comparison Project. Phase 1

    NASA Technical Reports Server (NTRS)

    Lin, Ruei-Fong; Starr, David O'C.; DeMott, Paul J.; Cotton, Richard; Jensen, Eric; Sassen, Kenneth

    2000-01-01

    The Cirrus Parcel Model Comparison (CPMC) is a project of the GEWEX Cloud System Study Working Group on Cirrus Cloud Systems (GCSS WG2). The primary goal of this project is to identify cirrus model sensitivities to the state of our knowledge of nucleation and microphysics. Furthermore, the common ground of the findings may provide guidelines for models with simpler cirrus microphysics modules. We focus on the nucleation regimes of the warm (parcel starting at -40 C and 340 hPa) and cold (-60 C and 170 hPa) cases studied in the GCSS WG2 Idealized Cirrus Model Comparison Project. Nucleation and ice crystal growth were forced through an externally imposed rate of lift and consequent adiabatic cooling. The background haze particles are assumed to be lognormally-distributed H2SO4 particles. Only the homogeneous nucleation mode is allowed to form ice crystals in the HN-ONLY runs; all nucleation modes are switched on in the ALL-MODE runs. Participants were asked to run the HN-lambda-fixed runs by setting lambda = 2 (lambda is further discussed in section 2) or tailoring the nucleation rate calculation in agreement with lambda = 2 (exp 1). The depth of parcel lift (800 m) was set to assure that parcels underwent complete transition through the nucleation regime to a stage of approximate equilibrium between ice mass growth and vapor supplied by the specified updrafts.

  16. 7 CFR 318.13-15 - Parcel post inspection.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 5 2014-01-01 2014-01-01 false Parcel post inspection. 318.13-15 Section 318.13-15... From Hawaii and the Territories § 318.13-15 Parcel post inspection. Inspectors are authorized to inspect, with the cooperation of the U.S. Postal Service, parcel post packages placed in the mails...

  17. Project Overview: United Parcel Service's Second-Generation Hybrid-Electric Delivery Vans (Fact Sheet)

    SciTech Connect

    Not Available

    2011-11-01

    This fact sheet describes UPS second generation hybrid-electric delivery vehicles as compared to conventional delivery vehicles. Medium-duty commercial vehicles such as moving trucks, beverage-delivery trucks, and package-delivery vans consume almost 2,000 gal of fuel per year on average. United Parcel Service (UPS) operates hybrid-electric package-delivery vans to reduce the fuel use and emissions of its fleet. In 2008, the National Renewable Energy Laboratory's (NREL's) Fleet Test and Evaluation Team evaluated the first generation of UPS' hybrid delivery vans. These hybrid vans demonstrated 29%-37% higher fuel economy than comparable conventional diesel vans, which contributed to UPS' decision to add second-generation hybrid vans to its fleet. The Fleet Test and Evaluation Team is now evaluating the 18-month, in-service performance of 11 second-generation hybrid vans and 11 comparable conventional diesel vans operated by UPS in Minneapolis, Minnesota. The evaluation also includes testing fuel economy and emissions at NREL's Renewable Fuels and Lubricants (ReFUEL) Laboratory and comparing diesel particulate filter (DPF) regeneration. In addition, a followup evaluation of UPS' first-generation hybrid vans will show how those vehicles performed over three years of operation. One goal of this project is to provide a consistent comparison of fuel economy and operating costs between the second-generation hybrid vans and comparable conventional vans. Additional goals include quantifying the effects of hybridization on DPF regeneration and helping UPS select delivery routes for its hybrid vans that maximize the benefits of hybrid technology. This document introduces the UPS second-generation hybrid evaluation project. Final results will be available in mid-2012.

  18. Air parcel random walk and droplet spectra broadening in clouds.

    PubMed

    Turitsyn, K S

    2003-06-01

    We study the effect of turbulent flow on the droplet growth in a cloud during the condensation phase. Using the air parcel model, we describe analytically how the size distribution of droplets evolves at the different stages of parcel movement. We show that turbulent random walk superimposed on an accelerated ascent of the parcel makes the relative width of droplet distribution to grow initially as t(1/2) and then decay as t(-3/2).

  19. Shape-based multifeature brain parcellation

    NASA Astrophysics Data System (ADS)

    Nadeem, Saad; Kaufman, Arie

    2016-03-01

    We present a novel approach to parcellate - delineate the anatomical feature (folds, gyri, sulci) boundaries - the brain cortex. Our approach is based on extracting the 3D brain cortical surface mesh from magnetic resonance (MR) images, computing the shape measures (area, mean curvature, geodesic, and travel depths) for this mesh, and delineating the anatomical feature boundaries using these measures. We use angle-area preserving mapping of the cortical surface mesh to a simpler topology (disk or rectangle) to aid in the visualization and delineation of these boundaries. Contrary to commonly used generic 2D brain image atlas-based approaches, we use 3D surface mesh data extracted from a given brain MR imaging data and its specific shape measures for the parcellation. Our method does not require any non-linear registration of a given brain dataset to a generic atlas and hence, does away with the structure similarity assumption critical to the atlas-based approaches. We evaluate our approach using Mindboggle manually labeled brain datasets and achieve the following accuracies: 72.4% for gyri, 78.5% for major sulci, and 98.4% for folds. These results warrant further investigation of this approach as an alternative or as an initialization to the atlas-based approaches.

  20. Automatic parcellation of longitudinal cortical surfaces

    NASA Astrophysics Data System (ADS)

    Alassaf, Manal H.; Hahn, James K.

    2015-03-01

    We present a novel automatic method to parcellate the cortical surfaces of the neonatal brain longitudinal atlas at different stages of development. A labeled brain atlas of newborn at 41 weeks gestational age (GA) is used to propagate labels of anatomical regions of interest to an unlabeled spatio-temporal atlas, which provides a dynamic model of brain development at each week between 28-44 GA weeks. First, labels from the cortical volume of the labeled newborn brain are propagated to an age-matched cortical surface from the spatio-temporal atlas. Then, labels are propagated across the cortical surfaces of each week of the spatio-temporal atlas by registering successive cortical surfaces using a novel approach and an energy optimization function. This procedure incorporates local and global, spatial and temporal information when assigning the labels to each surface. The result is a complete parcellation of 17 neonatal brain surfaces of the spatio-temporal atlas with similar points per labels distributions across weeks.

  1. Manual MRI parcellation of the frontal lobe.

    PubMed

    Ranta, Marin E; Crocetti, Deana; Clauss, Jacqueline A; Kraut, Michael A; Mostofsky, Stewart H; Kaufmann, Walter E

    2009-05-15

    The ability to examine associations between neuropsychiatric conditions and functionally relevant frontal lobe sub-regions is a fundamental goal in neuropsychiatry, but methods for identifying frontal sub-regions in MR (magnetic resonance) images are not well established. Prior published techniques have principally defined gyral regions that do not necessarily correspond to known functional divisions. We present a method in which sulcal-gyral landmarks are used to manually delimit functionally relevant regions within the frontal lobe: primary motor cortex, anterior cingulate, deep white matter, premotor cortex regions (supplementary motor complex (SMC), frontal eye field and lateral premotor cortex) and prefrontal cortex (PFC) regions (medial PFC, dorsolateral PFC (DLPFC), inferior PFC, lateral orbitofrontal cortex (OFC) and medial OFC). Feasibility was tested by applying the protocol to brain MR data from 15 boys with attention-deficit/hyperactivity disorder (ADHD) and 15 typically developing controls, 8-12 years old. Intra- and inter-rater intraclass correlation coefficients were calculated using parcellation volumes from a subset of that group. Inter-rater results for the 22 hemisphere specific sub-regions ranged from 0.724 to 0.997, with all but seven values above 0.9. Boys with ADHD showed significantly smaller left hemisphere SMC and DLPFC volumes after normalization for total cerebral volume. These findings support the method as a reliable and valid technique for parcellating the frontal lobe into functionally relevant sub-regions.

  2. Manual MRI parcellation of the frontal lobe

    PubMed Central

    Richardson, Marin E.; Crocetti, Deana; Clauss, Jacqueline A.; Kraut, Michael A.; Mostofsky, Stewart H.; Kaufmann, Walter E.

    2009-01-01

    The ability to examine associations between neuropsychiatric conditions and functionally relevant frontal lobe sub-regions is a fundamental goal in neuropsychiatry, but methods for identifying frontal sub-regions in MR (magnetic resonance) images are not well established. Prior published techniques have principally defined gyral regions that do not necessarily correspond to known functional divisions. We present a method in which sulcal-gyral landmarks are used to manually delimit functionally relevant regions within the frontal lobe: primary motor cortex, anterior cingulate, deep white matter, premotor cortex regions (supplementary motor complex (SMC), frontal eye field and lateral premotor cortex) and prefrontal cortex (PFC) regions (medial PFC, dorsolateral PFC (DLPFC), inferior PFC, lateral orbitofrontal cortex (OFC) and medial OFC). Feasibility was tested by applying the protocol to brain MR data from 15 boys with ADHD and 15 typically developing controls, 8–12 years old. Intra- and inter-rater intraclass correlation coefficients were calculated using parcellation volumes from a subset of that group. Inter-rater results for the 22 hemisphere specific sub-regions ranged from 0.724 to 0.997, with all but six values above 0.9. Boys with ADHD showed significantly smaller left hemisphere SMC and DLPFC volumes after normalization for total cerebral volume. These findings support the method as a reliable and valid technique for parcellating the frontal lobe into functionally relevant subregions. PMID:19324532

  3. 75 FR 52378 - Transfer of Commercial Standard Mail Parcels to Competitive Product List

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-25

    ... Commission to transfer commercial Standard Mail Parcels from the Mail Classification Schedule's Market... to transfer commercial Standard Mail Parcels from the Mail Classification Schedule's Market Dominant... Commercial Standard Mail Parcels to Competitive Product List AGENCY: Postal Service. TM ACTION:...

  4. 7 CFR 1955.140 - Sale in parcels.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 14 2011-01-01 2011-01-01 false Sale in parcels. 1955.140 Section 1955.140...) PROGRAM REGULATIONS (CONTINUED) PROPERTY MANAGEMENT Disposal of Inventory Property General § 1955.140 Sale... Programs property, may be offered for sale as a whole or subdivided into parcels as determined by the...

  5. 19. John and James Dobson Carpet Mills, West parcel, topographical ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    19. John and James Dobson Carpet Mills, West parcel, topographical plan, 1986. Barton and Martin, Engineers. 'Topographical Plan for Dobson Mills.' Prepared for Rouse Urban Housing, Inc., Philadelphia, Pennsylvania, 1986. - John & James Dobson Carpet Mill (West Parcel), 4041-4055 Ridge Avenue, Philadelphia, Philadelphia County, PA

  6. 12. John and James Dobson Carpet Mill, West Parcel, site ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. John and James Dobson Carpet Mill, West Parcel, site plan-upper right, and surrounding environs, 1884. Hopkins, Griffith Morgan. City Atlas of Philadelphia by Wards, 7 vols., Philadelphia, Pennsylvania: G. M. Hopkins and Co., 1884, Plate 9. - John & James Dobson Carpet Mill (West Parcel), 4041-4055 Ridge Avenue, Philadelphia, Philadelphia County, PA

  7. 48 CFR 242.1404-1 - Parcel post eligible shipments.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Parcel post eligible shipments. 242.1404-1 Section 242.1404-1 Federal Acquisition Regulations System DEFENSE ACQUISITION... Traffic and Transportation Management 242.1404-1 Parcel post eligible shipments. (b)(1) See DoD...

  8. 48 CFR 242.1404-1 - Parcel post eligible shipments.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Parcel post eligible shipments. 242.1404-1 Section 242.1404-1 Federal Acquisition Regulations System DEFENSE ACQUISITION... Traffic and Transportation Management 242.1404-1 Parcel post eligible shipments. (b)(1) See DoD...

  9. Parcellating Cortical Functional Networks in Individuals

    PubMed Central

    Wang, Danhong; Buckner, Randy L.; Fox, Michael D.; Holt, Daphne J.; Holmes, Avram J.; Stoecklein, Sophia; Langs, Georg; Pan, Ruiqi; Qian, Tianyi; Li, Kuncheng; Baker, Justin T.; Stufflebeam, Steven M.; Wang, Kai; Wang, Xiaomin; Hong, Bo; Liu, Hesheng

    2015-01-01

    The capacity to identify the unique functional architecture of an individual’s brain is a critical step towards personalized medicine and understanding the neural basis of variations in human cognition and behavior. Here, we developed a novel cortical parcellation approach to accurately map functional organization at the individual level using resting-state fMRI. A population-based functional atlas and a map of inter-individual variability were employed to guide the iterative search for functional networks in individual subjects. Functional networks mapped by this approach were highly reproducible within subjects and effectively captured the variability across subjects, including individual differences in brain lateralization. The algorithm performed well across different subject populations and data types including task fMRI data. The approach was then validated by invasive cortical stimulation mapping in surgical patients, suggesting great potential for use in clinical applications. PMID:26551545

  10. Automated MRI parcellation of the frontal lobe

    PubMed Central

    Ranta, Marin E.; Chen, Min; Crocetti, Deana; Prince, Jerry L.; Subramaniam, Krish; Fischl, Bruce; Kaufmann, Walter E.; Mostofsky, Stewart H.

    2014-01-01

    Examination of associations between specific disorders and physical properties of functionally relevant frontal lobe sub-regions is a fundamental goal in neuropsychiatry. Here we present and evaluate automated methods of frontal lobe parcellation with the programs FreeSurfer(FS) and TOADS-CRUISE(T-C), based on the manual method described in Ranta et al. (2009) in which sulcal-gyral landmarks were used to manually delimit functionally relevant regions within the frontal lobe: i.e., primary motor cortex, anterior cingulate, deep white matter, premotor cortex regions (supplementary motor complex, frontal eye field and lateral premotor cortex) and prefrontal cortex (PFC) regions (medial PFC, dorsolateral PFC, inferior PFC, lateral orbitofrontal cortex (OFC) and medial OFC). Dice's coefficient, a measure of overlap, and percent volume difference were used to measure the reliability between manual and automated delineations for each frontal lobe region. For FS, mean Dice's coefficient for all regions was 0.75 and percent volume difference was 21.2%. For T-C the mean Dice's coefficient was 0.77 and the mean percent volume difference for all regions was 20.2%. These results, along with a high degree of agreement between the two automated methods (mean Dice's coefficient = 0.81, percent volume difference = 12.4%) and a proof-of-principle group difference analysis that highlights the consistency and sensitivity of the automated methods, indicate that the automated methods are valid techniques for parcellation of the frontal lobe into functionally relevant sub-regions. Thus, the methodology has the potential to increase efficiency, statistical power and reproducibility for population analyses of neuropsychiatric disorders with hypothesized frontal lobe contributions. PMID:23897577

  11. A simple parcel method for prediction of cumulus onset and area-averaged cloud amount over heterogeneous land surfaces

    NASA Technical Reports Server (NTRS)

    Wetzel, Peter J.

    1990-01-01

    A set of PBL data selected from the Wangara experiment is used to examine the relationship between cumulus amount and the calculated relative humidity of rising parcels. The Wilde et al. (1985) method is compared to two explicit parcel methods. It is shown that predictions using parcel methods, in which surface air is lifted to its equilibrium level while being diluted by a defined amount of mixed layer air, are superior for cloud amount, especially during periods of rapid cloud onset when the mean boundary layer top is swiftly rising through a near-neutral layer. Pending independent verification, it appears that an rms error in instantaneous cloud amount of + or - 10 percent may be achievable.

  12. Variability in Parameter Estimates and Model Fit across Repeated Allocations of Items to Parcels

    ERIC Educational Resources Information Center

    Sterba, Sonya K.; MacCallum, Robert C.

    2010-01-01

    Different random or purposive allocations of items to parcels within a single sample are thought not to alter structural parameter estimates as long as items are unidimensional and congeneric. If, additionally, numbers of items per parcel and parcels per factor are held fixed across allocations, different allocations of items to parcels within a…

  13. Hydraulic Hybrid Parcel Delivery Truck Deployment, Testing & Demonstration

    SciTech Connect

    Gallo, Jean-Baptiste

    2014-03-07

    Although hydraulic hybrid systems have shown promise over the last few years, commercial deployment of these systems has primarily been limited to Class 8 refuse trucks. In 2005, the Hybrid Truck Users Forum initiated the Parcel Delivery Working Group including the largest parcel delivery fleets in North America. The goal of the working group was to evaluate and accelerate commercialization of hydraulic hybrid technology for parcel delivery vehicles. FedEx Ground, Purolator and United Parcel Service (UPS) took delivery of the world’s first commercially available hydraulic hybrid parcel delivery trucks in early 2012. The vehicle chassis includes a Parker Hannifin hydraulic hybrid drive system, integrated and assembled by Freightliner Custom Chassis Corp., with a body installed by Morgan Olson. With funding from the U.S. Department of Energy, CALSTART and its project partners assessed the performance, reliability, maintainability and fleet acceptance of three pre-production Class 6 hydraulic hybrid parcel delivery vehicles using information and data from in-use data collection and on-road testing. This document reports on the deployment of these vehicles operated by FedEx Ground, Purolator and UPS. The results presented provide a comprehensive overview of the performance of commercial hydraulic hybrid vehicles in parcel delivery applications. This project also informs fleets and manufacturers on the overall performance of hydraulic hybrid vehicles, provides insights on how the technology can be both improved and more effectively used. The key findings and recommendations of this project fall into four major categories: -Performance, -Fleet deployment, -Maintenance, -Business case. Hydraulic hybrid technology is relatively new to the market, as commercial vehicles have been introduced only in the past few years in refuse and parcel delivery applications. Successful demonstration could pave the way for additional purchases of hydraulic hybrid vehicles throughout the

  14. A GIS-based shape index for land parcels

    NASA Astrophysics Data System (ADS)

    Demetriou, Demetris; Stillwell, John; See, Linda

    2013-08-01

    Shape analysis is of interest in many fields of spatial science and planning including land management in rural areas. In particular, evaluating the shape of existing land parcels is critical when implementing rural development schemes such as land consolidation. However, existing land parcel shape indices have major deficiencies: completely different shapes of parcels may have the same index value or similar parcel shapes may have different index scores. Thus, there is a clear requirement for a more accurate and reliable measurement method. This paper therefore presents a new parcel shape index (PSI) which integrates a geographical information system (GIS) with a multi-attribute decision-making (MADM) method. It involves the amalgamated outcome of six geometric measures represented by value functions involving a mathematical representation of judgements by experts that compare each geometric measure with that of an optimum parcel shape defined for land consolidation projects. The optimum shape has a PSI value of 1 while the worst shape has a value close to 0. The shape measures used in the model include length of sides, acute angles, reflex angles, boundary points, compactness and regularity. The paper uses data for two case study areas in Cyprus to demonstrate the superiority of the new PSI over three existing shape indices employed in other studies. The methodology utilized here can be implemented in other disciplines dealing with the assessment of objects that can be compared to an optimum.

  15. Impact of the resolution of brain parcels on connectome-wide association studies in fMRI.

    PubMed

    Bellec, Pierre; Benhajali, Yassine; Carbonell, Felix; Dansereau, Christian; Albouy, Geneviève; Pelland, Maxime; Craddock, Cameron; Collignon, Oliver; Doyon, Julien; Stip, Emmanuel; Orban, Pierre

    2015-12-01

    A recent trend in functional magnetic resonance imaging is to test for association of clinical disorders with every possible connection between selected brain parcels. We investigated the impact of the resolution of functional brain parcels, ranging from large-scale networks to local regions, on a mass univariate general linear model (GLM) of connectomes. For each resolution taken independently, the Benjamini-Hochberg procedure controlled the false-discovery rate (FDR) at nominal level on realistic simulations. However, the FDR for tests pooled across all resolutions could be inflated compared to the FDR within resolution. This inflation was severe in the presence of no or weak effects, but became negligible for strong effects. We thus developed an omnibus test to establish the overall presence of true discoveries across all resolutions. Although not a guarantee to control the FDR across resolutions, the omnibus test may be used for descriptive analysis of the impact of resolution on a GLM analysis, in complement to a primary analysis at a predefined single resolution. On three real datasets with significant omnibus test (schizophrenia, congenital blindness, motor practice), markedly higher rate of discovery were obtained at low resolutions, below 50, in line with simulations showing increase in sensitivity at such resolutions. This increase in discovery rate came at the cost of a lower ability to localize effects, as low resolution parcels merged many different brain regions together. However, with 30 or more parcels, the statistical effect maps were biologically plausible and very consistent across resolutions. These results show that resolution is a key parameter for GLM-connectome analysis with FDR control, and that a functional brain parcellation with 30 to 50 parcels may lead to an accurate summary of full connectome effects with good sensitivity in many situations.

  16. GCSS Cirrus Parcel Model Comparison Project

    NASA Technical Reports Server (NTRS)

    Lin, Ruei-Fong; Starr, David OC.; DeMott, Paul J.; Cotton, Richard; Jensen, Eric; Sassen, Kenneth; Einaudi, Franco (Technical Monitor)

    2000-01-01

    The Cirrus Parcel Model Comparison Project, a project of GCSS Working Group on Cirrus Cloud Systems (WG2), involves the systematic comparison of current models of ice crystal nucleation and growth for specified, typical, cirrus cloud environments. The goal of this project is to document and understand the factors resulting in significant inter-model differences. The intent is to foment research leading to model improvement and validation. In Phase 1 of the project reported here, simulated cirrus cloud microphysical properties are compared for situations of "warm" (-40 C) and "cold" (-60 C) cirrus subject to updrafts of 4, 20 and 100 cm/s, respectively. Five models participated. These models employ explicit microphysical schemes wherein the size distribution of each class of particles (aerosols and ice crystals) is resolved into bins. Simulations are made including both homogeneous and heterogeneous ice nucleation mechanisms. A single initial aerosol population of sulfuric acid particles is prescribed for all simulations. To isolate the treatment of the homogeneous freezing (of haze drops) nucleation process, the heterogeneous nucleation mechanism is disabled for a second parallel set of simulations. Qualitative agreement is found for the homogeneous-nucleation-only simulations, e.g., the number density of nucleated ice crystals increases with the strength of the prescribed updraft. However, non-negligible quantitative differences are found. Detailed analysis reveals that the homogeneous nucleation formulation, aerosol size, ice crystal growth rate (particularly the deposition coefficient), and water vapor uptake rate are critical components that lead to differences in predicted microphysics. Systematic bias exists between results based on a modified classical theory approach and models using an effective freezing temperature approach to the treatment of nucleation. Each approach is constrained by critical freezing data from laboratory studies, but each includes

  17. Semi-automatic parcellation of the corpus striatum

    NASA Astrophysics Data System (ADS)

    Al-Hakim, Ramsey; Nain, Delphine; Levitt, James; Shenton, Martha; Tannenbaum, Allen

    2007-03-01

    The striatum is the input component of the basal ganglia from the cerebral cortex. It includes the caudate, putamen, and nucleus accumbens. Thus, the striatum is an important component in limbic frontal-subcortical circuitry and is believed to be relevant both for reward-guided behaviors and for the expression of psychosis. The dorsal striatum is composed of the caudate and putamen, both of which are further subdivided into pre- and post-commissural components. The ventral striatum (VS) is primarily composed of the nucleus accumbens. The striatum can be functionally divided into three broad regions: 1) a limbic; 2) a cognitive and 3) a sensor-motor region. The approximate corresponding anatomic subregions for these 3 functional regions are: 1) the VS; 2) the pre/post-commissural caudate and the pre-commissural putamen and 3) the post-commissural putamen. We believe assessing these subregions, separately, in disorders with limbic and cognitive impairment such as schizophrenia may yield more informative group differences in comparison with normal controls than prior parcellation strategies of the striatum such as assessing the caudate and putamen. The manual parcellation of the striatum into these subregions is currently defined using certain landmark points and geometric rules. Since identification of these areas is important to clinical research, a reliable and fast parcellation technique is required. Currently, only full manual parcellation using editing software is available; however, this technique is extremely time intensive. Previous work has shown successful application of heuristic rules into a semi-automatic platform1. We present here a semi-automatic algorithm which implements the rules currently used for manual parcellation of the striatum, but requires minimal user input and significantly reduces the time required for parcellation.

  18. United Parcel Service Evaluates Hybrid Electric Delivery Vans (Fact Sheet)

    SciTech Connect

    Not Available

    2010-02-01

    This fact sheet describes how the National Renewable Energy Laboratory's Fleet Test and Evaluation team evaluated the 12-month, in-service performance of six Class 4 hybrid electric delivery vans - fueled by regular diesel - and six comparable conventional diesel vans operated by the United Parcel Service.

  19. View of structures at rear of parcel with 12' scale ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of structures at rear of parcel with 12' scale (in tenths). From right: edge of Round House, Pencil house, Shell House, edge of School House. Heart Shrine made from mortared car headlights at frame left. Camera facing east. - Grandma Prisbrey's Bottle Village, 4595 Cochran Street, Simi Valley, Ventura County, CA

  20. 7 CFR 318.13-15 - Parcel post inspection.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 5 2011-01-01 2011-01-01 false Parcel post inspection. 318.13-15 Section 318.13-15 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE STATE OF HAWAII AND TERRITORIES QUARANTINE NOTICES Regulated...

  1. 7 CFR 318.13-15 - Parcel post inspection.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Parcel post inspection. 318.13-15 Section 318.13-15 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE STATE OF HAWAII AND TERRITORIES QUARANTINE NOTICES Regulated...

  2. Center of parcel with picture tube wall along walkway. Leaning ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Center of parcel with picture tube wall along walkway. Leaning Tower of Bottle Village at frame right; oblique view of Rumpus Room, remnants of Little Hut destroyed by Northridge earthquake at frame left. Camera facing northeast. - Grandma Prisbrey's Bottle Village, 4595 Cochran Street, Simi Valley, Ventura County, CA

  3. 7 CFR 318.13-15 - Parcel post inspection.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 5 2012-01-01 2012-01-01 false Parcel post inspection. 318.13-15 Section 318.13-15 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION... subpart, to examine any such products that are found for insect infestation, and to notify the...

  4. A multi-modal parcellation of human cerebral cortex.

    PubMed

    Glasser, Matthew F; Coalson, Timothy S; Robinson, Emma C; Hacker, Carl D; Harwell, John; Yacoub, Essa; Ugurbil, Kamil; Andersson, Jesper; Beckmann, Christian F; Jenkinson, Mark; Smith, Stephen M; Van Essen, David C

    2016-08-11

    Understanding the amazingly complex human cerebral cortex requires a map (or parcellation) of its major subdivisions, known as cortical areas. Making an accurate areal map has been a century-old objective in neuroscience. Using multi-modal magnetic resonance images from the Human Connectome Project (HCP) and an objective semi-automated neuroanatomical approach, we delineated 180 areas per hemisphere bounded by sharp changes in cortical architecture, function, connectivity, and/or topography in a precisely aligned group average of 210 healthy young adults. We characterized 97 new areas and 83 areas previously reported using post-mortem microscopy or other specialized study-specific approaches. To enable automated delineation and identification of these areas in new HCP subjects and in future studies, we trained a machine-learning classifier to recognize the multi-modal 'fingerprint' of each cortical area. This classifier detected the presence of 96.6% of the cortical areas in new subjects, replicated the group parcellation, and could correctly locate areas in individuals with atypical parcellations. The freely available parcellation and classifier will enable substantially improved neuroanatomical precision for studies of the structural and functional organization of human cerebral cortex and its variation across individuals and in development, aging, and disease. PMID:27437579

  5. Use of Item Parceling in Structural Equation Modeling with Missing Data

    ERIC Educational Resources Information Center

    Orcan, Fatih

    2013-01-01

    Parceling is referred to as a procedure for computing sums or average scores across multiple items. Parcels instead of individual items are then used as indicators of latent factors in the structural equation modeling analysis (Bandalos 2002, 2008; Little et al., 2002; Yang, Nay, & Hoyle, 2010). Item parceling may be applied to alleviate some…

  6. 15 CFR 740.12 - Gift parcels and humanitarian donations (GFT).

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...—(i) Item limitations—(A) Prohibited items. (1) For Cuba no items listed on the Commerce Control List... in gift parcels. (iii) Frequency. (A) Except for gift parcels of food to Cuba, not more than one gift... frequency limit on gift parcels of food to Cuba. (C) Parties seeking authorization to exceed the...

  7. Reading Disabled and ADD Children: Similarities and Differences.

    ERIC Educational Resources Information Center

    Dykman, Roscoe A.; And Others

    This paper covers selected findings from three studies that compared different diagnostic groups: boys with attention deficit disorder (ADD) with or without hyperactivity (HY) but normal reading ability; boys with reading disability (RD) but not HY; and boys with both RD and HY. Studies examined an adapted task to assess frontal and temporal lobe…

  8. Functional connectivity based parcellation of the human medial temporal lobe.

    PubMed

    Wang, Shao-Fang; Ritchey, Maureen; Libby, Laura A; Ranganath, Charan

    2016-10-01

    Regional differences in large-scale connectivity have been proposed to underlie functional specialization along the anterior-posterior axis of the medial temporal lobe (MTL), including the hippocampus (HC) and the parahippocampal gyrus (PHG). However, it is unknown whether functional connectivity (FC) can be used reliably to parcellate the human MTL. The current study aimed to differentiate subregions of the HC and the PHG based on patterns of whole-brain intrinsic FC. FC maps were calculated for each slice along the longitudinal axis of the PHG and the HC. A hierarchical clustering algorithm was then applied to these data in order to group slices according to the similarity of their connectivity patterns. Surprisingly, three discrete clusters were identified in the PHG. Two clusters corresponded to the parahippocampal cortex (PHC) and the perirhinal cortex (PRC), and these regions showed preferential connectivity with previously described posterior-medial and anterior-temporal networks, respectively. The third cluster corresponded to an anterior PRC region previously described as area 36d, and this region exhibited preferential connectivity with auditory cortical areas and with a network involved in visceral processing. The three PHG clusters showed different profiles of activation during a memory-encoding task, demonstrating that the FC-based parcellation identified functionally dissociable sub-regions of the PHG. In the hippocampus, no sub-regions were identified via the parcellation procedure. These results indicate that connectivity-based methods can be used to parcellate functional regions within the MTL, and they suggest that studies of memory and high-level cognition need to differentiate between PHC, posterior PRC, and anterior PRC.

  9. The Brain Atlas Concordance Problem: Quantitative Comparison of Anatomical Parcellations

    PubMed Central

    Bohland, Jason W.; Bokil, Hemant; Allen, Cara B.; Mitra, Partha P.

    2009-01-01

    Many neuroscientific reports reference discrete macro-anatomical regions of the brain which were delineated according to a brain atlas or parcellation protocol. Currently, however, no widely accepted standards exist for partitioning the cortex and subcortical structures, or for assigning labels to the resulting regions, and many procedures are being actively used. Previous attempts to reconcile neuroanatomical nomenclatures have been largely qualitative, focusing on the development of thesauri or simple semantic mappings between terms. Here we take a fundamentally different approach, discounting the names of regions and instead comparing their definitions as spatial entities in an effort to provide more precise quantitative mappings between anatomical entities as defined by different atlases. We develop an analytical framework for studying this brain atlas concordance problem, and apply these methods in a comparison of eight diverse labeling methods used by the neuroimaging community. These analyses result in conditional probabilities that enable mapping between regions across atlases, which also form the input to graph-based methods for extracting higher-order relationships between sets of regions and to procedures for assessing the global similarity between different parcellations of the same brain. At a global scale, the overall results demonstrate a considerable lack of concordance between available parcellation schemes, falling within chance levels for some atlas pairs. At a finer level, this study reveals spatial relationships between sets of defined regions that are not obviously apparent; these are of high potential interest to researchers faced with the challenge of comparing results that were based on these different anatomical models, particularly when coordinate-based data are not available. The complexity of the spatial overlap patterns revealed points to problems for attempts to reconcile anatomical parcellations and nomenclatures using strictly

  10. Air parcel trajectory dispersion near the tropical tropopause

    NASA Astrophysics Data System (ADS)

    Bergman, John W.; Jensen, Eric J.; Pfister, Leonhard; Bui, Thaopaul V.

    2016-04-01

    Dispersion of backward air parcel trajectories that are initially tightly grouped near the tropical tropopause is examined using three ensemble approaches: "RANWIND," in which different ensemble members use identical resolved wind fluctuations but different realizations of stochastic, multifractal simulations of unresolved winds; "PERTLOC," in which members use identical resolved wind fields but initial locations are perturbed 2° in latitude and longitude; and a multimodel ensemble ("MULTIMODEL") that uses identical initial conditions but different resolved wind fields and/or trajectory formulations. Comparisons among the approaches distinguish, to some degree, physical dispersion from that due to data uncertainty and the impacts of unresolved wind fluctuations from those of resolved variability. Dispersion rates are robust properties of trajectories near the tropical tropopause. Horizontal dispersion rates are typically ~3°/d, which is large enough to spread parcels throughout the tropics within typical tropical tropopause layer transport times (30-60 days) and underscores the importance of averaging large collections of trajectories to obtain reliable parcel source and pathway distributions. Vertical dispersion rates away from convection are ~2-3 hPa/d. Dispersion is primarily carried out by the resolved flow, and the RANWIND approach provides a plausible representation of actual trajectory dispersion rates, while PERTLOC provides a reasonable and inexpensive alternative to RANWIND. In contrast, dispersion from the MULTIMODEL calculations is important because it reflects systematic differences in resolved wind fields from different reanalysis data sets.

  11. Evolution of chemically processed air parcels in the lower stratosphere

    NASA Technical Reports Server (NTRS)

    Stolarski, Richard S.; Douglass, Anne R.; Schoeberl, Mark R.

    1994-01-01

    Aircraft, ground-based, and satellite measurements indicate large concentrations of ClO in the lower stratosphere in and near the polar vortex. The amount of local ozone depletion caused by these large ClO concentrations will depend on the relative rates of ozone loss and ClO recovery. ClO recovery occurs when NO(x), from HNO3 photolysis, reacts with ClO to form ClONO2. We show that air parcels with large amounts of ClO will experience a subsequent ozone depletion that depends on the solar zenith angle. When the solar zenith angle is large in the middle of winter, the recovery of the ClO concentration in the parcel is slow relative to ozone depletion. In the spring, when the solar zenith angle is smaller, the ClO recovery is much faster. After ClO recovery, the chlorine chemistry has not returned to normal. The ClO has been converted to ClONO2. ClO production from further encounters with PSCs will be limited by the heterogeneous reaction of ClONO2 with water. Large ozone depletions, of the type seen in the Antarctic, occur only if there is significant irreversible denitrification in the air parcel.

  12. Expert System For Flexible Palletizing Of Mixed Size And Weight Parcels

    NASA Astrophysics Data System (ADS)

    Mazouz, A. Kader; Shell, Richard L.; Hall, E. L.

    1988-02-01

    Stacking boxes of mixed size and weight is a tedious task requiring intelligence. It requires the ability to recognize that boxes are available to be stacked, the recognition of different box types, the selection of a grasping point for picking up the box and most importantly, a determination of where to stack the box on a partially loaded pallet. The purpose of this paper is to describe an expert system for determining how to stack a set of mixed size and weight boxes and provide control information to a robot to perform actual palletizing. A prototype system has been developed using an expert programming language and an industrial robot work cell. The system has been tested with actual food parcels weighing up to 50 pounds and performs very well. The formation of flat regions is one of the many rules implemented in the expert system. The system also works at speeds comparable to human speeds. The study demonstrates, in large measure, the feasibility of the use of expert system AI techniques and industrial robots for palletizing mixed size weight parcels in a general workhousing application.

  13. Evaluating the Characteristics of Social Vulnerability to Wildfire: Demographics, Perceptions, and Parcel Characteristics.

    PubMed

    Paveglio, Travis B; Prato, Tony; Edgeley, Catrin; Nalle, Darek

    2016-09-01

    A large body of research focuses on identifying patterns of human populations most at risk from hazards and the factors that help explain performance of mitigations that can help reduce that risk. One common concept in such studies is social vulnerability-human populations' potential exposure to, sensitivity from and ability to reduce negative impacts from a hazard. While there is growing interest in social vulnerability for wildfire, few studies have critically evaluated the characteristics that scholars often indicate influence social vulnerability to that hazard. This research utilizes surveys, wildfire simulations, and GIS data to test the relationships between select demographic, perceptual and parcel characteristics of property owners against empirically simulated metrics for wildfire exposure or wildfire-related damages and their performance of mitigation actions. Our results from Flathead County, MT, USA, suggest that parcel characteristics such as property value, building value, and the year structures were built explaining a significant amount of the variance in elements of social vulnerability. Demographic characteristics commonly used in social vulnerability analysis did not have significant relationships with measures of wildfire exposure or vulnerability. Part-time or full-time residency, age, perceived property risk, and year of development were among the few significant determinants of residents' performance of fuel reduction mitigations, although the significance of these factors varied across the levels of fuel reduction performed by homeowners. We use these and other results to argue for a renewed focus on the finer-scale characteristics that expose some populations to wildfire risk more than others.

  14. Evaluating the Characteristics of Social Vulnerability to Wildfire: Demographics, Perceptions, and Parcel Characteristics

    NASA Astrophysics Data System (ADS)

    Paveglio, Travis B.; Prato, Tony; Edgeley, Catrin; Nalle, Darek

    2016-09-01

    A large body of research focuses on identifying patterns of human populations most at risk from hazards and the factors that help explain performance of mitigations that can help reduce that risk. One common concept in such studies is social vulnerability—human populations' potential exposure to, sensitivity from and ability to reduce negative impacts from a hazard. While there is growing interest in social vulnerability for wildfire, few studies have critically evaluated the characteristics that scholars often indicate influence social vulnerability to that hazard. This research utilizes surveys, wildfire simulations, and GIS data to test the relationships between select demographic, perceptual and parcel characteristics of property owners against empirically simulated metrics for wildfire exposure or wildfire-related damages and their performance of mitigation actions. Our results from Flathead County, MT, USA, suggest that parcel characteristics such as property value, building value, and the year structures were built explaining a significant amount of the variance in elements of social vulnerability. Demographic characteristics commonly used in social vulnerability analysis did not have significant relationships with measures of wildfire exposure or vulnerability. Part-time or full-time residency, age, perceived property risk, and year of development were among the few significant determinants of residents' performance of fuel reduction mitigations, although the significance of these factors varied across the levels of fuel reduction performed by homeowners. We use these and other results to argue for a renewed focus on the finer-scale characteristics that expose some populations to wildfire risk more than others.

  15. Evaluating the Characteristics of Social Vulnerability to Wildfire: Demographics, Perceptions, and Parcel Characteristics.

    PubMed

    Paveglio, Travis B; Prato, Tony; Edgeley, Catrin; Nalle, Darek

    2016-09-01

    A large body of research focuses on identifying patterns of human populations most at risk from hazards and the factors that help explain performance of mitigations that can help reduce that risk. One common concept in such studies is social vulnerability-human populations' potential exposure to, sensitivity from and ability to reduce negative impacts from a hazard. While there is growing interest in social vulnerability for wildfire, few studies have critically evaluated the characteristics that scholars often indicate influence social vulnerability to that hazard. This research utilizes surveys, wildfire simulations, and GIS data to test the relationships between select demographic, perceptual and parcel characteristics of property owners against empirically simulated metrics for wildfire exposure or wildfire-related damages and their performance of mitigation actions. Our results from Flathead County, MT, USA, suggest that parcel characteristics such as property value, building value, and the year structures were built explaining a significant amount of the variance in elements of social vulnerability. Demographic characteristics commonly used in social vulnerability analysis did not have significant relationships with measures of wildfire exposure or vulnerability. Part-time or full-time residency, age, perceived property risk, and year of development were among the few significant determinants of residents' performance of fuel reduction mitigations, although the significance of these factors varied across the levels of fuel reduction performed by homeowners. We use these and other results to argue for a renewed focus on the finer-scale characteristics that expose some populations to wildfire risk more than others. PMID:27272166

  16. Intrinsic functional connectivity pattern-based brain parcellation using normalized cut

    NASA Astrophysics Data System (ADS)

    Cheng, Hewei; Song, Dandan; Wu, Hong; Fan, Yong

    2012-02-01

    In imaging data based brain network analysis, a necessary precursor for constructing meaningful brain networks is to identify functionally homogeneous regions of interest (ROIs) for defining network nodes. For parcellating the brain based on resting state fMRI data, normalized cut is one widely used clustering algorithm which groups voxels according to the similarity of functional signals. Due to low signal to noise ratio (SNR) of resting state fMRI signals, spatial constraint is often applied to functional similarity measures to generate smooth parcellation. However, improper spatial constraint might alter the intrinsic functional connectivity pattern, thus yielding biased parcellation results. To achieve reliable and least biased parcellation of the brain, we propose an optimization method for the spatial constraint to functional similarity measures in normalized cut based brain parcellation. Particularly, we first identify the space of all possible spatial constraints that are able to generate smooth parcellation, then find the spatial constraint that leads to the brain parcellation least biased from the intrinsic function pattern based parcellation, measured by the minimal Ncut value calculated based on the functional similarity measure of original functional signals. The proposed method has been applied to the parcellation of medial superior frontal cortex for 20 subjects based on their resting state fMRI data. The experiment results indicate that our method can generate meaningful parcellation results, consistent with existing functional anatomy knowledge.

  17. ADDE: Application Development for the Distributed Enterprise.

    ERIC Educational Resources Information Center

    Franckson, Marcel; Hall, John; Helmerich, Alfred; Canadas, Rafael; Dehn, Martin

    1998-01-01

    Describes the Application Development for the Distributed Enterprise (ADDE) project, a methodological set that supports the design of distributed business processes and information and communication technologies. Discusses principles behind ADDE, guidance on definition and planning of application development, guidance on distributed application…

  18. Inviting Calm Within: ADD, Neurology, and Mindfulness

    ERIC Educational Resources Information Center

    Riner, Phillip S.; Tanase, Madalina

    2014-01-01

    The fourth edition of the "Diagnostic and Statistical Manual of Mental Disorders" ("DSM IV") describes ADD as behaviorally observed impairments in attention, impulsivity, and hyperactivity. Officially known as AD/HD, we use ADD here because we are dealing primarily with attention, organizational, and impulsivity issues. A more…

  19. ADD Teacher Inservice Project. Final Grant Report.

    ERIC Educational Resources Information Center

    Edwards, Mark C.; Schulz, Eldon G.

    The report describes activities and achievements of the Attention Deficit Disorder (ADD) Teacher Inservice Project. The inservice program was developed using a formal process to identify the critical issues related to ADD awareness, assessment, and intervention. Program content was designed to address critical issues identified in the research…

  20. Approaching Expert Results Using a Hierarchical Cerebellum Parcellation Protocol for Multiple Inexpert Human Raters

    PubMed Central

    Bogovic, John A.; Jedynak, Bruno; Rigg, Rachel; Du, Annie; Landman, Bennett A.; Prince, Jerry L.; Ying, Sarah H.

    2012-01-01

    Volumetric measurements obtained from image parcellation have been instrumental in uncovering structure-function relationships. However, anatomical study of the cerebellum is a challenging task. Because of its complex structure, expert human raters have been necessary for reliable and accurate segmentation and parcellation. Such delineations are time-consuming and prohibitively expensive for large studies. Therefore, we present a three-part cerebellar parcellation system that utilizes multiple inexpert human raters that can efficiently and expediently produce results nearly on par with those of experts. This system includes a hierarchical delineation protocol, a rapid verification and evaluation process, and statistical fusion of the inexpert rater parcellations. The quality of the raters’ and fused parcellations was established by examining their Dice similarity coefficient, region of interest (ROI) volumes, and the intraclass correlation coefficient of region volume. The intra-rater ICC was found to be 0.93 at the finest level of parcellation. PMID:22975160

  1. Co-activation based parcellation of the human frontal pole.

    PubMed

    Ray, K L; Zald, D H; Bludau, S; Riedel, M C; Bzdok, D; Yanes, J; Falcone, K E; Amunts, K; Fox, P T; Eickhoff, S B; Laird, A R

    2015-12-01

    Historically, the human frontal pole (FP) has been considered as a single architectonic area. Brodmann's area 10 is located in the frontal lobe with known contributions in the execution of various higher order cognitive processes. However, recent cytoarchitectural studies of the FP in humans have shown that this portion of cortex contains two distinct cytoarchitectonic regions. Since architectonic differences are accompanied by differential connectivity and functions, the frontal pole qualifies as a candidate region for exploratory parcellation into functionally discrete sub-regions. We investigated whether this functional heterogeneity is reflected in distinct segregations within cytoarchitectonically defined FP-areas using meta-analytic co-activation based parcellation (CBP). The CBP method examined the co-activation patterns of all voxels within the FP as reported in functional neuroimaging studies archived in the BrainMap database. Voxels within the FP were subsequently clustered into sub-regions based on the similarity of their respective meta-analytically derived co-activation maps. Performing this CBP analysis on the FP via k-means clustering produced a distinct 3-cluster parcellation for each hemisphere corresponding to previously identified cytoarchitectural differences. Post-hoc functional characterization of clusters via BrainMap metadata revealed that lateral regions of the FP mapped to memory and emotion domains, while the dorso- and ventromedial clusters were associated broadly with emotion and social cognition processes. Furthermore, the dorsomedial regions contain an emphasis on theory of mind and affective related paradigms whereas ventromedial regions couple with reward tasks. Results from this study support previous segregations of the FP and provide meta-analytic contributions to the ongoing discussion of elucidating functional architecture within human FP. PMID:26254112

  2. Subject-specific functional parcellation via Prior Based Eigenanatomy

    PubMed Central

    Dhillon, Paramveer S.; Wolk, David A.; Das, Sandhitsu R.; Ungar, Lyle H.; Gee, James C.; Avants, Brian B.

    2015-01-01

    We present a new framework for prior-constrained sparse decomposition of matrices derived from the neuroimaging data and apply this method to functional network analysis of a clinically relevant population. Matrix decomposition methods are powerful dimensionality reduction tools that have found widespread use in neuroimaging. However, the unconstrained nature of these totally data-driven techniques makes it difficult to interpret the results in a domain where network-specific hypotheses may exist. We propose a novel approach, Prior Based Eigenanatomy (p-Eigen), which seeks to identify a data-driven matrix decomposition but at the same time constrains the individual components by spatial anatomical priors (probabilistic ROIs). We formulate our novel solution in terms of prior-constrained ℓ1 penalized (sparse) principal component analysis. p-Eigen starts with a common functional parcellation for all the subjects and refines it with subject-specific information. This enables modeling of the inter-subject variability in the functional parcel boundaries and allows us to construct subject specific networks with reduced sensitivity to ROI placement. We show that while still maintaining correspondence across subjects, p-Eigen extracts biologically-relevant and patient-specific functional parcels that facilitate hypothesis-driven network analysis. We construct Default Mode Network (DMN) connectivity graphs using p-Eigen refined ROIs and use them in a classification paradigm. Our results show that the functional connectivity graphs derived from p-Eigen significantly aid classification of Mild Cognitive Impairment (MCI) as well as the prediction of scores in a Delayed Recall memory task when compared to graph metrics derived from 1) standard registration-based seed ROI definitions, 2) totally data driven ROIs 3) a model based on standard demographics plus hippocampal volume as covariates and 4) Ward Clustering based data driven ROIs. In summary, p-Eigen incarnates a new

  3. Using natural beta emission for detecting concealed tobacco in parcels

    NASA Astrophysics Data System (ADS)

    Myers, Jeremy; Hussein, Esam M. A.

    2007-10-01

    It is suspected that postal systems are used for the illegal shipment of tobacco products to circumvent taxation and excise payments. This paper demonstrates that beta-particle emission from the potassium-40 contained in tobacco can be used to passively detect its presence in paperboard postal parcels. The same concept can be utilized for the detection of marijuana, whose leaves are also rich in 40K. The combination of high beta activity and a low weight is a good indicator of the presence of these two contraband materials.

  4. Oblique along path toward structures at rear of parcel. Original ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Oblique along path toward structures at rear of parcel. Original skinny mosaic path along edge of structures was altered (delineation can be seen in concrete) path was widened with a newer mosaic to make access to the site safer. Structures (from right) edge of Round House (with "Spring Garden"), Pencil house, Shell House, School House, wood lattice is attached to chain-link fence along north (rear) property line. These structures were all damaged by the 1994 Northridge earthquake. Camera facing northeast. - Grandma Prisbrey's Bottle Village, 4595 Cochran Street, Simi Valley, Ventura County, CA

  5. Cerebellar Functional Parcellation Using Sparse Dictionary Learning Clustering.

    PubMed

    Wang, Changqing; Kipping, Judy; Bao, Chenglong; Ji, Hui; Qiu, Anqi

    2016-01-01

    The human cerebellum has recently been discovered to contribute to cognition and emotion beyond the planning and execution of movement, suggesting its functional heterogeneity. We aimed to identify the functional parcellation of the cerebellum using information from resting-state functional magnetic resonance imaging (rs-fMRI). For this, we introduced a new data-driven decomposition-based functional parcellation algorithm, called Sparse Dictionary Learning Clustering (SDLC). SDLC integrates dictionary learning, sparse representation of rs-fMRI, and k-means clustering into one optimization problem. The dictionary is comprised of an over-complete set of time course signals, with which a sparse representation of rs-fMRI signals can be constructed. Cerebellar functional regions were then identified using k-means clustering based on the sparse representation of rs-fMRI signals. We solved SDLC using a multi-block hybrid proximal alternating method that guarantees strong convergence. We evaluated the reliability of SDLC and benchmarked its classification accuracy against other clustering techniques using simulated data. We then demonstrated that SDLC can identify biologically reasonable functional regions of the cerebellum as estimated by their cerebello-cortical functional connectivity. We further provided new insights into the cerebello-cortical functional organization in children.

  6. Cerebellar Functional Parcellation Using Sparse Dictionary Learning Clustering

    PubMed Central

    Wang, Changqing; Kipping, Judy; Bao, Chenglong; Ji, Hui; Qiu, Anqi

    2016-01-01

    The human cerebellum has recently been discovered to contribute to cognition and emotion beyond the planning and execution of movement, suggesting its functional heterogeneity. We aimed to identify the functional parcellation of the cerebellum using information from resting-state functional magnetic resonance imaging (rs-fMRI). For this, we introduced a new data-driven decomposition-based functional parcellation algorithm, called Sparse Dictionary Learning Clustering (SDLC). SDLC integrates dictionary learning, sparse representation of rs-fMRI, and k-means clustering into one optimization problem. The dictionary is comprised of an over-complete set of time course signals, with which a sparse representation of rs-fMRI signals can be constructed. Cerebellar functional regions were then identified using k-means clustering based on the sparse representation of rs-fMRI signals. We solved SDLC using a multi-block hybrid proximal alternating method that guarantees strong convergence. We evaluated the reliability of SDLC and benchmarked its classification accuracy against other clustering techniques using simulated data. We then demonstrated that SDLC can identify biologically reasonable functional regions of the cerebellum as estimated by their cerebello-cortical functional connectivity. We further provided new insights into the cerebello-cortical functional organization in children. PMID:27199650

  7. Measuring Narcissism within Add Health: The Development and Validation of a New Scale

    ERIC Educational Resources Information Center

    Davis, Mark S.; Brunell, Amy B.

    2012-01-01

    This study reports the development of a measure of narcissism within the National Longitudinal Study of Adolescent Health (Add Health) data set. In Study 1, items were selected from Wave III to form the Add Health Narcissism Scale (AHNS). These were factor analyzed, yielding a single factor comprised of five subscales. We correlated the AHNS and…

  8. 39 CFR 320.7 - Suspension for advertisements accompanying parcels or periodicals.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Suspension for advertisements accompanying parcels... advertisements accompanying parcels or periodicals. (a) The operation of 39 U.S.C. 601(a) (1) through (6) and § 310.2(b) (1) through (6) of this chapter is suspended on all post routes for advertisements...

  9. 77 FR 43561 - Proposed Eligibility Criteria for Bound Printed Matter Parcels

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-25

    ... 111 Proposed Eligibility Criteria for Bound Printed Matter Parcels AGENCY: Postal Service TM . ACTION... criterion for eligibility of Bound Printed Matter (BPM) parcels by adding a physical density threshold for... matter, weighing no more than 15 pounds and requiring postage payment by permit imprint. BPM is...

  10. Semi-supervised clustering for parcellating brain regions based on resting state fMRI data

    NASA Astrophysics Data System (ADS)

    Cheng, Hewei; Fan, Yong

    2014-03-01

    Many unsupervised clustering techniques have been adopted for parcellating brain regions of interest into functionally homogeneous subregions based on resting state fMRI data. However, the unsupervised clustering techniques are not able to take advantage of exiting knowledge of the functional neuroanatomy readily available from studies of cytoarchitectonic parcellation or meta-analysis of the literature. In this study, we propose a semi-supervised clustering method for parcellating amygdala into functionally homogeneous subregions based on resting state fMRI data. Particularly, the semi-supervised clustering is implemented under the framework of graph partitioning, and adopts prior information and spatial consistent constraints to obtain a spatially contiguous parcellation result. The graph partitioning problem is solved using an efficient algorithm similar to the well-known weighted kernel k-means algorithm. Our method has been validated for parcellating amygdala into 3 subregions based on resting state fMRI data of 28 subjects. The experiment results have demonstrated that the proposed method is more robust than unsupervised clustering and able to parcellate amygdala into centromedial, laterobasal, and superficial parts with improved functionally homogeneity compared with the cytoarchitectonic parcellation result. The validity of the parcellation results is also supported by distinctive functional and structural connectivity patterns of the subregions and high consistency between coactivation patterns derived from a meta-analysis and functional connectivity patterns of corresponding subregions.

  11. Robust brain parcellation using sparse representation on resting-state fMRI.

    PubMed

    Zhang, Yu; Caspers, Svenja; Fan, Lingzhong; Fan, Yong; Song, Ming; Liu, Cirong; Mo, Yin; Roski, Christian; Eickhoff, Simon; Amunts, Katrin; Jiang, Tianzi

    2015-11-01

    Resting-state fMRI (rs-fMRI) has been widely used to segregate the brain into individual modules based on the presence of distinct connectivity patterns. Many parcellation methods have been proposed for brain parcellation using rs-fMRI, but their results have been somewhat inconsistent, potentially due to various types of noise. In this study, we provide a robust parcellation method for rs-fMRI-based brain parcellation, which constructs a sparse similarity graph based on the sparse representation coefficients of each seed voxel and then uses spectral clustering to identify distinct modules. Both the local time-varying BOLD signals and whole-brain connectivity patterns may be used as features and yield similar parcellation results. The robustness of our method was tested on both simulated and real rs-fMRI datasets. In particular, on simulated rs-fMRI data, sparse representation achieved good performance across different noise levels, including high accuracy of parcellation and high robustness to noise. On real rs-fMRI data, stable parcellation of the medial frontal cortex (MFC) and parietal operculum (OP) were achieved on three different datasets, with high reproducibility within each dataset and high consistency across these results. Besides, the parcellation of MFC was little influenced by the degrees of spatial smoothing. Furthermore, the consistent parcellation of OP was also well corresponding to cytoarchitectonic subdivisions and known somatotopic organizations. Our results demonstrate a new promising approach to robust brain parcellation using resting-state fMRI by sparse representation.

  12. SMI-32 parcellates the visual cortical areas of the marmoset.

    PubMed

    Baldauf, Zsolt B

    The distribution pattern of SMI-32-immunoreactivity (SMI-32-ir) of neuronal elements was examined in the visual cortical areas of marmoset monkey. Layer IV of the primary visual cortex (V1) and layers III and V of the extrastriate areas showed the most abundant SMI-32-ir. The different areal and laminar distribution of SMI-32-ir allowed the distinction between various extrastriate areas and determined their exact anatomical boundaries in the New World monkey, Callithrix penicillata. It is shown here that the parcellating nature of SMI-32 described earlier in the visual cortical areas of other mammals - including Old World monkeys - is also present in the marmoset. Furthermore, a comparison became possible between the chemoanatomical organization of New World and Old World primates' visual cortical areas.

  13. Nonreciprocal photonic crystal add-drop filter

    NASA Astrophysics Data System (ADS)

    Tao, Keyu; Xiao, Jun-Jun; Yin, Xiaobo

    2014-11-01

    We present a versatile add-drop integrated photonic filter (ADF) consisting of nonreciprocal waveguides in which the propagation of light is restricted in one predetermined direction. With the bus and add/drop waveguides symmetrically coupled through a cavity, the four-port device allows each individual port to add and/or drop a signal of the same frequency. The scheme is general and we demonstrate the nonreciprocal ADF with magneto-optical photonic crystals. The filter is immune to waveguide defects, allowing straightforward implementation of multi-channel ADFs by cascading the four-port designs. The results should find applications in wavelength-division multiplexing and related integrated photonic techniques.

  14. Nonreciprocal photonic crystal add-drop filter

    SciTech Connect

    Tao, Keyu; Xiao, Jun-Jun; Yin, Xiaobo

    2014-11-24

    We present a versatile add-drop integrated photonic filter (ADF) consisting of nonreciprocal waveguides in which the propagation of light is restricted in one predetermined direction. With the bus and add/drop waveguides symmetrically coupled through a cavity, the four-port device allows each individual port to add and/or drop a signal of the same frequency. The scheme is general and we demonstrate the nonreciprocal ADF with magneto-optical photonic crystals. The filter is immune to waveguide defects, allowing straightforward implementation of multi-channel ADFs by cascading the four-port designs. The results should find applications in wavelength-division multiplexing and related integrated photonic techniques.

  15. Shift-and-add for astronomical imaging

    NASA Technical Reports Server (NTRS)

    Ribak, Erez; Hege, E. Keith; Strobel, Nicolas V.; Christou, Julian C.

    1989-01-01

    Diffraction-limited astronomical images have been obtained utilizing a variant of the shift-and-add method. It is shown that the matched filter approach for extending the weighted shift-and-add method reduces specklegrams from extended objects and from an object dominated by photon noise. The method is aberration-insensitive and yields very high dynamic range results. The iterative method for arriving at the matched filter does not automatically converge in the case of photon-noisy specklegrams for objects with more than one maximum.

  16. Randomized Controlled Trials of Add-On Antidepressants in Schizophrenia

    PubMed Central

    Joffe, Grigori; Stenberg, Jan-Henry

    2015-01-01

    Background: Despite adequate treatment with antipsychotics, a substantial number of patients with schizophrenia demonstrate only suboptimal clinical outcome. To overcome this challenge, various psychopharmacological combination strategies have been used, including antidepressants added to antipsychotics. Methods: To analyze the efficacy of add-on antidepressants for the treatment of negative, positive, cognitive, depressive, and antipsychotic-induced extrapyramidal symptoms in schizophrenia, published randomized controlled trials assessing the efficacy of adjunctive antidepressants in schizophrenia were reviewed using the following parameters: baseline clinical characteristics and number of patients, their on-going antipsychotic treatment, dosage of the add-on antidepressants, duration of the trial, efficacy measures, and outcomes. Results: There were 36 randomized controlled trials reported in 41 journal publications (n=1582). The antidepressants used were the selective serotonin reuptake inhibitors, duloxetine, imipramine, mianserin, mirtazapine, nefazodone, reboxetin, trazodone, and bupropion. Mirtazapine and mianserin showed somewhat consistent efficacy for negative symptoms and both seemed to enhance neurocognition. Trazodone and nefazodone appeared to improve the antipsychotics-induced extrapyramidal symptoms. Imipramine and duloxetine tended to improve depressive symptoms. No clear evidence supporting selective serotonin reuptake inhibitors’ efficacy on any clinical domain of schizophrenia was found. Add-on antidepressants did not worsen psychosis. Conclusions: Despite a substantial number of randomized controlled trials, the overall efficacy of add-on antidepressants in schizophrenia remains uncertain mainly due to methodological issues. Some differences in efficacy on several schizophrenia domains seem, however, to exist and to vary by the antidepressant subgroups—plausibly due to differences in the mechanisms of action. Antidepressants may not worsen

  17. 76 FR 49508 - ``Add Us In'' Initiative

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-10

    ... Federal Register on August 4, 2011 at 76 FR 150. Specifically, we are correcting the Funding Opportunity... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF LABOR Office of Disability Employment Program ``Add Us In'' Initiative AGENCY: Office of Disability...

  18. The Cirrus Parcel Model Comparison Project. Phase 1

    NASA Technical Reports Server (NTRS)

    Lin, Ruei-Fong; Starr, D.; DeMott, P.; Cotten, R.; Jensen, E.; Sassen, K.

    2000-01-01

    The cirrus Parcel Model Comparison Project involves the systematic comparison of current models of ice crystal nucleation and growth for specified, typical, cirrus cloud environments. In Phase 1 of the project reported here, simulated cirrus cloud microphysical properties are compared for situations of "warm" (-40 C) and "cold" (-60 C) cirrus subject to updrafts of 4, 20 and 100 centimeters per second, respectively. Five models are participating in the project. These models employ explicit microphysical schemes wherein the size distribution of each class of particles (aerosols and ice crystals) is resolved into bins. Simulations are made including both homogeneous and heterogeneous ice nucleation mechanisms. A single initial aerosol population of sulfuric acid particles is prescribed for all simulations. To isolate the treatment of the homogeneous freezing (of haze drops) nucleation process, the heterogeneous nucleation mechanism is disabled for a second parallel set of simulations. Qualitative agreement is found amongst the models for the homogeneous-nucleation-only simulations, e.g., the number density of nucleated ice crystals increases with the strength of the prescribed updraft. However, non-negligible quantitative differences are found. Systematic bias exists between results of a model based on a modified classical theory approach and models using an effective freezing temperature approach to the treatment of nucleation. Each approach is constrained by critical freezing data from laboratory studies. This information is necessary, but not sufficient, to construct consistent formulae for the two approaches. Large haze particles may deviate considerably from equilibrium size in moderate to strong updrafts (20-100 centimeters per second) at -60 C when the commonly invoked equilibrium assumption is lifted. The resulting difference in particle-size-dependent solution concentration of haze particles may significantly affect the ice nucleation rate during the initial

  19. Why item parcels are (almost) never appropriate: two wrongs do not make a right--camouflaging misspecification with item parcels in CFA models.

    PubMed

    Marsh, Herbert W; Lüdtke, Oliver; Nagengast, Benjamin; Morin, Alexandre J S; Von Davier, Matthias

    2013-09-01

    The present investigation has a dual focus: to evaluate problematic practice in the use of item parcels and to suggest exploratory structural equation models (ESEMs) as a viable alternative to the traditional independent clusters confirmatory factor analysis (ICM-CFA) model (with no cross-loadings, subsidiary factors, or correlated uniquenesses). Typically, it is ill-advised to (a) use item parcels when ICM-CFA models do not fit the data, and (b) retain ICM-CFA models when items cross-load on multiple factors. However, the combined use of (a) and (b) is widespread and often provides such misleadingly good fit indexes that applied researchers might believe that misspecification problems are resolved--that 2 wrongs really do make a right. Taking a pragmatist perspective, in 4 studies we demonstrate with responses to the Rosenberg Self-Esteem Inventory (Rosenberg, 1965), Big Five personality factors, and simulated data that even small cross-loadings seriously distort relations among ICM-CFA constructs or even decisions on the number of factors; although obvious in item-level analyses, this is camouflaged by the use of parcels. ESEMs provide a viable alternative to ICM-CFAs and a test for the appropriateness of parcels. The use of parcels with an ICM-CFA model is most justifiable when the fit of both ICM-CFA and ESEM models is acceptable and equally good, and when substantively important interpretations are similar. However, if the ESEM model fits the data better than the ICM-CFA model, then the use of parcels with an ICM-CFA model typically is ill-advised--particularly in studies that are also interested in scale development, latent means, and measurement invariance.

  20. 76 FR 23749 - Intelligent Mail Package Barcode (IMpb) Implementation for Commercial Parcels

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-28

    ... 111 Intelligent Mail Package Barcode (IMpb) Implementation for Commercial Parcels AGENCY: Postal... currently enhancing its operational capability to allow for the scanning of Intelligent Mail package barcodes (IMpb) and other extra services barcodes via automated processing equipment and Intelligent...

  1. 133. PARCEL HANDLING SPACE OF POST OFFICE BUILDING, LEVEL 72.5, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    133. PARCEL HANDLING SPACE OF POST OFFICE BUILDING, LEVEL 72.5, NORTH OF TRUCKING PASSAGE MAIL TRANSPORT AREA, VIEW TO NORTHWEST - Terminal Tower Building, Cleveland Union Terminal, 50 Public Square, Cleveland, Cuyahoga County, OH

  2. Connectivity-based parcellation of the human frontal polar cortex.

    PubMed

    Moayedi, Massieh; Salomons, Tim V; Dunlop, Katharine A M; Downar, Jonathan; Davis, Karen D

    2015-09-01

    The frontal pole corresponds to Brodmann area (BA) 10, the largest single architectonic area in the human frontal lobe. Generally, BA10 is thought to contain two or three subregions that subserve broad functions such as multitasking, social cognition, attention, and episodic memory. However, there is a substantial debate about the functional and structural heterogeneity of this large frontal region. Previous connectivity-based parcellation studies have identified two or three subregions in the human frontal pole. Here, we used diffusion tensor imaging to assess structural connectivity of BA10 in 35 healthy subjects and delineated subregions based on this connectivity. This allowed us to determine the correspondence of structurally based subregions with the scheme previously defined functionally. Three subregions could be defined in each subject. However, these three subregions were not spatially consistent between subjects. Therefore, we accepted a solution with two subregions that encompassed the lateral and medial frontal pole. We then examined resting-state functional connectivity of the two subregions and found significant differences between their connectivities. The medial cluster was connected to nodes of the default-mode network, which is implicated in internally focused, self-related thought, and social cognition. The lateral cluster was connected to nodes of the executive control network, associated with directed attention and working memory. These findings support the concept that there are two major anatomical subregions of the frontal pole related to differences in functional connectivity.

  3. Intracellular parcel service: current issues in intracellular membrane trafficking.

    PubMed

    Herrmann, Johannes M; Spang, Anne

    2015-01-01

    Eukaryotic cells contain a multitude of membrane structures that are connected through a highly dynamic and complex exchange of their constituents. The vibrant instability of these structures challenges the classical view of defined, static compartments that are connected by different types of vesicles. Despite this astonishing complexity, proteins and lipids are accurately transported into the different intracellular membrane systems. Over the past few decades many factors have been identified that either mediate or regulate intracellular membrane trafficking. Like in a modern parcel sorting system of a logistics center, the cargo typically passes through several sequential sorting stations until it finally reaches the location that is specified by its individual address label. While each membrane system employs specific sets of factors, the transport processes typically operate on common principles. With the advent of genome- and proteome-wide screens, the availability of mutant collections, exciting new developments in microscope technology and sophisticated methods to study their dynamics, the future promises a broad and comprehensive picture of the processes by which eukaryotic cells sort their proteins.

  4. Tractography-based Parcellation of the Human Middle Temporal Gyrus

    PubMed Central

    Xu, Jinping; Wang, Jiaojian; Fan, Lingzhong; Li, Hai; Zhang, Wen; Hu, Qingmao; Jiang, Tianzi

    2015-01-01

    The middle temporal gyrus (MTG) participates in a variety of functions, suggesting the existence of distinct functional subregions. In order to further delineate the functions of this brain area, we parcellated the MTG based on its distinct anatomical connectivity profiles and identified four distinct subregions, including the anterior (aMTG), middle (mMTG), posterior (pMTG), and sulcus (sMTG). Both the anatomical connectivity patterns and the resting-state functional connectivity patterns revealed distinct connectivity profiles for each subregion. The aMTG was primarily involved in the default mode network, sound recognition, and semantic retrieval. The mMTG was predominantly involved in the semantic memory and semantic control networks. The pMTG seems to be a part of the traditional sensory language area. The sMTG appears to be associated with decoding gaze direction and intelligible speech. Interestingly, the functional connectivity with Brodmann’s Area (BA) 40, BA 44, and BA 45 gradually increased from the anterior to the posterior MTG, a finding which indicated functional topographical organization as well as implying that language processing is functionally segregated in the MTG. These proposed subdivisions of the MTG and its functions contribute to understanding the complex functions of the MTG at the subregional level. PMID:26689815

  5. Calculation of Per Parcel Probability for Dud Bombs in Germany

    NASA Astrophysics Data System (ADS)

    Tavakkoli Sabour, S. M.; Agarius, J.; Sadidi, J.

    2014-10-01

    Unexploded aerial Bombs, also known as duds or unfused bombs, of the bombardments in the past wars remain explosive for decades after the war under the earth's surface threatening the civil activities especially if dredging works are involved. Interpretation of the aerial photos taken shortly after bombardments has been proven to be useful for finding the duds. Unfortunately, the reliability of this method is limited by some factors. The chance of finding a dud on an aerial photo depends strongly on the photography system, the size of the bomb and the landcover. On the other hand, exploded bombs are considerably better detectable on aerial photos and confidently represent the extent and density of a bombardment. Considering an empirical quota of unfused bombs, the expected number of duds can be calculated by the number of exploded bombs. This can help to have a better calculation of cost-risk ratio and to classify the areas for clearance. This article is about a method for calculation of a per parcel probability of dud bombs according to the distribution and density of exploded bombs. No similar work has been reported in this field by other authors.

  6. Improving reliability of subject-level resting-state fMRI parcellation with shrinkage estimators.

    PubMed

    Mejia, Amanda F; Nebel, Mary Beth; Shou, Haochang; Crainiceanu, Ciprian M; Pekar, James J; Mostofsky, Stewart; Caffo, Brian; Lindquist, Martin A

    2015-05-15

    A recent interest in resting state functional magnetic resonance imaging (rsfMRI) lies in subdividing the human brain into anatomically and functionally distinct regions of interest. For example, brain parcellation is often a necessary step for defining the network nodes used in connectivity studies. While inference has traditionally been performed on group-level data, there is a growing interest in parcellating single subject data. However, this is difficult due to the inherent low signal-to-noise ratio of rsfMRI data, combined with typically short scan lengths. A large number of brain parcellation approaches employ clustering, which begins with a measure of similarity or distance between voxels. The goal of this work is to improve the reproducibility of single-subject parcellation using shrinkage-based estimators of such measures, allowing the noisy subject-specific estimator to "borrow strength" in a principled manner from a larger population of subjects. We present several empirical Bayes shrinkage estimators and outline methods for shrinkage when multiple scans are not available for each subject. We perform shrinkage on raw inter-voxel correlation estimates and use both raw and shrinkage estimates to produce parcellations by performing clustering on the voxels. While we employ a standard spectral clustering approach, our proposed method is agnostic to the choice of clustering method and can be used as a pre-processing step for any clustering algorithm. Using two datasets - a simulated dataset where the true parcellation is known and is subject-specific and a test-retest dataset consisting of two 7-minute resting-state fMRI scans from 20 subjects - we show that parcellations produced from shrinkage correlation estimates have higher reliability and validity than those produced from raw correlation estimates. Application to test-retest data shows that using shrinkage estimators increases the reproducibility of subject-specific parcellations of the motor cortex by

  7. Improving Reliability of Subject-Level Resting-State fMRI Parcellation with Shrinkage Estimators

    PubMed Central

    Mejia, Amanda F.; Nebel, Mary Beth; Shou, Haochang; Crainiceanu, Ciprian M.; Pekar, James J.; Mostofsky, Stewart; Caffo, Brian; Lindquist, Martin A.

    2015-01-01

    A recent interest in resting state functional magnetic resonance imaging (rsfMRI) lies in subdividing the human brain into anatomically and functionally distinct regions of interest. For example, brain parcellation is often a necessary step for defining the network nodes used in connectivity studies. While inference has traditionally been performed on group-level data, there is a growing interest in parcellating single subject data. However, this is difficult due to the inherent low signal-to-noise ratio of rsfMRI data, combined with typically short scan lengths. A large number of brain parcellation approaches employ clustering, which begins with a measure of similarity or distance between voxels. The goal of this work is to improve the reproducibility of single-subject parcellation using shrinkage-based estimators of such measures, allowing the noisy subject-specific estimator to “borrow strength” in a principled manner from a larger population of subjects. We present several empirical Bayes shrinkage estimators and outline methods for shrinkage when multiple scans are not available for each subject. We perform shrinkage on raw inter-voxel correlation estimates and use both raw and shrinkage estimates to produce parcellations by performing clustering on the voxels. While we employ a standard spectral clustering approach, our proposed method is agnostic to the choice of clustering method and can be used as a pre-processing step for any clustering algorithm. Using two datasets – a simulated dataset where the true parcellation is known and is subject-specific and a test-retest dataset consisting of two 7-minute resting-state fMRI scans from 20 subjects – we show that parcellations produced from shrinkage correlation estimates have higher reliability and validity than those produced from raw correlation estimates. Application to test-retest data shows that using shrinkage estimators increases the reproducibility of subject-specific parcellations of the motor

  8. Improving reliability of subject-level resting-state fMRI parcellation with shrinkage estimators.

    PubMed

    Mejia, Amanda F; Nebel, Mary Beth; Shou, Haochang; Crainiceanu, Ciprian M; Pekar, James J; Mostofsky, Stewart; Caffo, Brian; Lindquist, Martin A

    2015-05-15

    A recent interest in resting state functional magnetic resonance imaging (rsfMRI) lies in subdividing the human brain into anatomically and functionally distinct regions of interest. For example, brain parcellation is often a necessary step for defining the network nodes used in connectivity studies. While inference has traditionally been performed on group-level data, there is a growing interest in parcellating single subject data. However, this is difficult due to the inherent low signal-to-noise ratio of rsfMRI data, combined with typically short scan lengths. A large number of brain parcellation approaches employ clustering, which begins with a measure of similarity or distance between voxels. The goal of this work is to improve the reproducibility of single-subject parcellation using shrinkage-based estimators of such measures, allowing the noisy subject-specific estimator to "borrow strength" in a principled manner from a larger population of subjects. We present several empirical Bayes shrinkage estimators and outline methods for shrinkage when multiple scans are not available for each subject. We perform shrinkage on raw inter-voxel correlation estimates and use both raw and shrinkage estimates to produce parcellations by performing clustering on the voxels. While we employ a standard spectral clustering approach, our proposed method is agnostic to the choice of clustering method and can be used as a pre-processing step for any clustering algorithm. Using two datasets - a simulated dataset where the true parcellation is known and is subject-specific and a test-retest dataset consisting of two 7-minute resting-state fMRI scans from 20 subjects - we show that parcellations produced from shrinkage correlation estimates have higher reliability and validity than those produced from raw correlation estimates. Application to test-retest data shows that using shrinkage estimators increases the reproducibility of subject-specific parcellations of the motor cortex by

  9. Accounting for Parcel-Allocation Variability in Practice: Combining Sources of Uncertainty and Choosing the Number of Allocations.

    PubMed

    Sterba, Sonya K; Rights, Jason D

    2016-01-01

    Item parceling remains widely used under conditions that can lead to parcel-allocation variability in results. Hence, researchers may be interested in quantifying and accounting for parcel-allocation variability within sample. To do so in practice, three key issues need to be addressed. First, how can we combine sources of uncertainty arising from sampling variability and parcel-allocation variability when drawing inferences about parameters in structural equation models? Second, on what basis can we choose the number of repeated item-to-parcel allocations within sample? Third, how can we diagnose and report proportions of total variability per estimate arising due to parcel-allocation variability versus sampling variability? This article addresses these three methodological issues. Developments are illustrated using simulated and empirical examples, and software for implementing them is provided.

  10. Hydrologic evaluation and water-supply considerations for five Paiute Indian land parcels, Millard, Sevier, and Iron counties, southwestern Utah

    USGS Publications Warehouse

    Price, Don; Stephens, D.W.; Conroy, L.S.

    1989-01-01

    The hydrologic resources in and adjacent to five parcels of land held in trust for the Paiute Indian Tribe of Utah were evaluated. The land, located in southwestern Utah, is generally arid and has had only limited use for grazing. The parcels are located near the towns of Cove Fort, Joseph, Koosharem, and Kanarraville. On the basis of available geohydrologic and hydrologic data, water of suitable quality is locally available in the areas of all parcels for domestic, stock, recreation, and limited irrigation use. Developing this water for use on the parcels would potentially involve obtaining water rights, drilling wells, and constructing diversion structures. Surface water apparently is the most favorable source of supply available for the Joseph parcel, and groundwater apparently is the most favorable source of supply available for the other parcels. (USGS)

  11. Census parcels cropping system classification from multitemporal remote imagery: a proposed universal methodology.

    PubMed

    García-Torres, Luis; Caballero-Novella, Juan J; Gómez-Candón, David; Peña, José Manuel

    2015-01-01

    A procedure named CROPCLASS was developed to semi-automate census parcel crop assessment in any agricultural area using multitemporal remote images. For each area, CROPCLASS consists of a) a definition of census parcels through vector files in all of the images; b) the extraction of spectral bands (SB) and key vegetation index (VI) average values for each parcel and image; c) the conformation of a matrix data (MD) of the extracted information; d) the classification of MD decision trees (DT) and Structured Query Language (SQL) crop predictive model definition also based on preliminary land-use ground-truth work in a reduced number of parcels; and e) the implementation of predictive models to classify unidentified parcels land uses. The software named CROPCLASS-2.0 was developed to semi-automatically perform the described procedure in an economically feasible manner. The CROPCLASS methodology was validated using seven GeoEye-1 satellite images that were taken over the LaVentilla area (Southern Spain) from April to October 2010 at 3- to 4-week intervals. The studied region was visited every 3 weeks, identifying 12 crops and others land uses in 311 parcels. The DT training models for each cropping system were assessed at a 95% to 100% overall accuracy (OA) for each crop within its corresponding cropping systems. The DT training models that were used to directly identify the individual crops were assessed with 80.7% OA, with a user accuracy of approximately 80% or higher for most crops. Generally, the DT model accuracy was similar using the seven images that were taken at approximately one-month intervals or a set of three images that were taken during early spring, summer and autumn, or set of two images that were taken at about 2 to 3 months interval. The classification of the unidentified parcels for the individual crops was achieved with an OA of 79.5%. PMID:25689830

  12. Census Parcels Cropping System Classification from Multitemporal Remote Imagery: A Proposed Universal Methodology

    PubMed Central

    García-Torres, Luis; Caballero-Novella, Juan J.; Gómez-Candón, David; Peña, José Manuel

    2015-01-01

    A procedure named CROPCLASS was developed to semi-automate census parcel crop assessment in any agricultural area using multitemporal remote images. For each area, CROPCLASS consists of a) a definition of census parcels through vector files in all of the images; b) the extraction of spectral bands (SB) and key vegetation index (VI) average values for each parcel and image; c) the conformation of a matrix data (MD) of the extracted information; d) the classification of MD decision trees (DT) and Structured Query Language (SQL) crop predictive model definition also based on preliminary land-use ground-truth work in a reduced number of parcels; and e) the implementation of predictive models to classify unidentified parcels land uses. The software named CROPCLASS-2.0 was developed to semi-automatically perform the described procedure in an economically feasible manner. The CROPCLASS methodology was validated using seven GeoEye-1 satellite images that were taken over the LaVentilla area (Southern Spain) from April to October 2010 at 3- to 4-week intervals. The studied region was visited every 3 weeks, identifying 12 crops and others land uses in 311 parcels. The DT training models for each cropping system were assessed at a 95% to 100% overall accuracy (OA) for each crop within its corresponding cropping systems. The DT training models that were used to directly identify the individual crops were assessed with 80.7% OA, with a user accuracy of approximately 80% or higher for most crops. Generally, the DT model accuracy was similar using the seven images that were taken at approximately one-month intervals or a set of three images that were taken during early spring, summer and autumn, or set of two images that were taken at about 2 to 3 months interval. The classification of the unidentified parcels for the individual crops was achieved with an OA of 79.5%. PMID:25689830

  13. User's manual for Axisymmetric Diffuser Duct (ADD) code. Volume 1: General ADD code description

    NASA Technical Reports Server (NTRS)

    Anderson, O. L.; Hankins, G. B., Jr.; Edwards, D. E.

    1982-01-01

    This User's Manual contains a complete description of the computer codes known as the AXISYMMETRIC DIFFUSER DUCT code or ADD code. It includes a list of references which describe the formulation of the ADD code and comparisons of calculation with experimental flows. The input/output and general use of the code is described in the first volume. The second volume contains a detailed description of the code including the global structure of the code, list of FORTRAN variables, and descriptions of the subroutines. The third volume contains a detailed description of the CODUCT code which generates coordinate systems for arbitrary axisymmetric ducts.

  14. Independents add gas reserves, forego romance

    SciTech Connect

    Gill, D.

    1981-08-01

    Incentive pricing for low-permeability reservoirs and tax advantages for drilling them are 2 big reasons why more independents may start making a special effort to add gas reserves to their inventories. If so, it will be a change from past practices, which saw independents build up big gas positions by circumstance rather than by intention. There are always major refiners ready and willing to buy whole crude oil reservoirs from small producers, but purchasers willing to take gas fields in a single investment are few and far between. Lower-than-normal return on equity during the first 20 years, plus the heavy front-end cost of a frac necessary to produce the tight gas might dissuade independents from drilling tight gas sands, but those liabilities are offset by the higher price tight gas gets and the peculiar tax advantages of exploring for it that make a nice fit with the small operator's way of doing business.

  15. Using Joint Interviews to Add Analytic Value.

    PubMed

    Polak, Louisa; Green, Judith

    2016-10-01

    Joint interviewing has been frequently used in health research, and is the subject of a growing methodological literature. We review this literature, and build on it by drawing on a case study of how people make decisions about taking statins. This highlights two ways in which a dyadic approach to joint interviewing can add analytic value compared with individual interviewing. First, the analysis of interaction within joint interviews can help to explicate tacit knowledge and to illuminate the range of often hard-to-access resources that are drawn upon in making decisions. Second, joint interviews mitigate some of the weaknesses of interviewing as a method for studying practices; we offer a cautious defense of the often-tacit assumption that the "naturalness" of joint interviews strengthens their credibility as the basis for analytic inferences. We suggest that joint interviews are a particularly appropriate method for studying complex shared practices such as making health decisions. PMID:25850721

  16. Identifying functional subdivisions in the human brain using meta-analytic activation modeling-based parcellation.

    PubMed

    Yang, Yong; Fan, Lingzhong; Chu, Congying; Zhuo, Junjie; Wang, Jiaojian; Fox, Peter T; Eickhoff, Simon B; Jiang, Tianzi

    2016-01-01

    Parcellation of the human brain into fine-grained units by grouping voxels into distinct clusters has been an effective approach for delineating specific brain regions and their subregions. Published neuroimaging studies employing coordinate-based meta-analyses have shown that the activation foci and their corresponding behavioral categories may contain useful information about the anatomical-functional organization of brain regions. Inspired by these developments, we proposed a new parcellation scheme called meta-analytic activation modeling-based parcellation (MAMP) that uses meta-analytically obtained information. The raw meta data, including the experiments and the reported activation coordinates related to a brain region of interest, were acquired from the Brainmap database. Using this data, we first obtained the "modeled activation" pattern by modeling the voxel-wise activation probability given spatial uncertainty for each experiment that featured at least one focus within the region of interest. Then, we processed these "modeled activation" patterns across the experiments with a K-means clustering algorithm to group the voxels into different subregions. In order to verify the reliability of the method, we employed our method to parcellate the amygdala and the left Brodmann area 44 (BA44). The parcellation results were quite consistent with previous cytoarchitectonic and in vivo neuroimaging findings. Therefore, the MAMP proposed in the current study could be a useful complement to other methods for uncovering the functional organization of the human brain.

  17. Novel fiber bottle microresonator add-drop filters

    NASA Astrophysics Data System (ADS)

    Senthil Murugan, Ganapathy; Wilkinson, James S.; Zervas, Michalis N.

    2010-02-01

    Novel bottle microresonators fabricated from standard telecommunications optical fiber were recently shown to support helical whispering gallery modes (WGMs) extending along the bottle length between the bottle necks. Intensity maxima were observed around the turning points on both sides close to the bottle necks where the WGMs are effectively reflected. Selective excitation on one side of the bottle microresonator leads to strong power localization at a symmetrically located turning point for the WGMs and can potentially be exploited to form effective add-drop filters. Channel dropping characteristics have been studied experimentally for the first time in this novel type of microresonator. A tapered optical fiber (drawn down to 2-3 microns in diameter with effective index of approximately 1.2) was placed on one side of the bottle to excite the bottle WGMs. A similar tapered fiber placed symmetrically on the other side of the bottle acted as a probe to extract the excited modes. We have successfully extracted power from all the resonance wavelengths using the probe placed at appropriate positions along the bottle, leading to the potential to construct efficient all fiber add-drop filters.

  18. Parcel: Project for the Automatic Restructuring and Concurrent Evaluation of Lisp

    SciTech Connect

    Harrison, W.L. III; Padua, D.A.

    1987-01-01

    Parcel (Project for the Automatic Restructuring and Concurrent Evaluation of Lisp) is an investigation of the problem of compiling Lisp for evaluation on a shared memory multiprocessor. In this paper, we present an overview of the process of compilation in Parcel. This process consists, broadly, of an interprocedural analysis, followed by the function-level restructuring of the lambda expressions composing a program. We discuss both of the phases, and illustrate the steps of restructuring with a few examples. A novel representation for s-expressions is employed in Parcel, to facilitate the parallel creation and access of lists; we review this representation, and discuss its implications for the compilation process. 14 refs., 8 figs.

  19. Parcellation of Infant Surface Atlas Using Developmental Trajectories of Multidimensional Cortical Attributes

    PubMed Central

    Li, Gang; Wang, Li; Gilmore, John H.; Lin, Weili; Shen, Dinggang

    2016-01-01

    Cortical surface atlases, equipped with anatomically and functionally defined parcellations, are of fundamental importance in neuroimaging studies. Typically, parcellations of surface atlases are derived based on the sulcal-gyral landmarks, which are extremely variable across individuals and poorly matched with microstructural and functional boundaries. Cortical developmental trajectories in infants reflect underlying changes of microstructures, which essentially determines the molecular organization and functional principles of the cortex, thus allowing better definition of developmentally, microstructurally, and functionally distinct regions, compared to conventional sulcal-gyral landmarks. Accordingly, a parcellation of infant cortical surface atlas was proposed, based on the developmental trajectories of cortical thickness in infants, revealing regional patterning of cortical growth. However, cortical anatomy is jointly characterized by biologically-distinct, multidimensional cortical attributes, i.e., cortical thickness, surface area, and local gyrification, each with its distinct genetic underpinning, cellular mechanism, and developmental trajectories. To date, the parcellations based on the development of surface area and local gyrification is still missing. To bridge this critical gap, for the first time, we parcellate an infant cortical surface atlas into distinct regions based solely on developmental trajectories of surface area and local gyrification, respectively. For each cortical attribute, we first nonlinearly fuse the subject-specific similarity matrices of vertices' developmental trajectories of all subjects into a single matrix, which helps better capture common and complementary information of the population than the conventional method of simple averaging of all subjects' matrices. Then, we perform spectral clustering based on this fused matrix. We have applied our method to parcellate an infant surface atlas using the developmental trajectories

  20. [Winter wheat area estimation with MODIS-NDVI time series based on parcel].

    PubMed

    Li, Le; Zhang, Jin-shui; Zhu, Wen-quan; Hu, Tan-gao; Hou, Dong

    2011-05-01

    Several attributes of MODIS (moderate resolution imaging spectrometer) data, especially the short temporal intervals and the global coverage, provide an extremely efficient way to map cropland and monitor its seasonal change. However, the reliability of their measurement results is challenged because of the limited spatial resolution. The parcel data has clear geo-location and obvious boundary information of cropland. Also, the spectral differences and the complexity of mixed pixels are weak in parcels. All of these make that area estimation based on parcels presents more advantage than on pixels. In the present study, winter wheat area estimation based on MODIS-NDVI time series has been performed with the support of cultivated land parcel in Tongzhou, Beijing. In order to extract the regional winter wheat acreage, multiple regression methods were used to simulate the stable regression relationship between MODIS-NDVI time series data and TM samples in parcels. Through this way, the consistency of the extraction results from MODIS and TM can stably reach up to 96% when the amount of samples accounts for 15% of the whole area. The results shows that the use of parcel data can effectively improve the error in recognition results in MODIS-NDVI based multi-series data caused by the low spatial resolution. Therefore, with combination of moderate and low resolution data, the winter wheat area estimation became available in large-scale region which lacks completed medium resolution images or has images covered with clouds. Meanwhile, it carried out the preliminary experiments for other crop area estimation.

  1. Parcellation of the human orbitofrontal cortex based on gray matter volume covariance.

    PubMed

    Liu, Huaigui; Qin, Wen; Qi, Haotian; Jiang, Tianzi; Yu, Chunshui

    2015-02-01

    The human orbitofrontal cortex (OFC) is an enigmatic brain region that cannot be parcellated reliably using diffusional and functional magnetic resonance imaging (fMRI) because there is signal dropout that results from an inherent defect in imaging techniques. We hypothesise that the OFC can be reliably parcellated into subregions based on gray matter volume (GMV) covariance patterns that are derived from artefact-free structural images. A total of 321 healthy young subjects were examined by high-resolution structural MRI. The OFC was parcellated into subregions-based GMV covariance patterns; and then sex and laterality differences in GMV covariance pattern of each OFC subregion were compared. The human OFC was parcellated into the anterior (OFCa), medial (OFCm), posterior (OFCp), intermediate (OFCi), and lateral (OFCl) subregions. This parcellation scheme was validated by the same analyses of the left OFC and the bilateral OFCs in male and female subjects. Both visual observation and quantitative comparisons indicated a unique GMV covariance pattern for each OFC subregion. These OFC subregions mainly covaried with the prefrontal and temporal cortices, cingulate cortex and amygdala. In addition, GMV correlations of most OFC subregions were similar across sex and laterality except for significant laterality difference in the OFCl. The right OFCl had stronger GMV correlation with the right inferior frontal cortex. Using high-resolution structural images, we established a reliable parcellation scheme for the human OFC, which may provide an in vivo guide for subregion-level studies of this region and improve our understanding of the human OFC at subregional levels.

  2. A role for α-adducin (ADD-1) in nematode and human memory

    PubMed Central

    Vukojevic, Vanja; Gschwind, Leo; Vogler, Christian; Demougin, Philippe; de Quervain, Dominique J-F; Papassotiropoulos, Andreas; Stetak, Attila

    2012-01-01

    Identifying molecular mechanisms that underlie learning and memory is one of the major challenges in neuroscience. Taken the advantages of the nematode Caenorhabditis elegans, we investigated α-adducin (add-1) in aversive olfactory associative learning and memory. Loss of add-1 function selectively impaired short- and long-term memory without causing acquisition, sensory, or motor deficits. We showed that α-adducin is required for consolidation of synaptic plasticity, for sustained synaptic increase of AMPA-type glutamate receptor (GLR-1) content and altered GLR-1 turnover dynamics. ADD-1, in a splice-form- and tissue-specific manner, controlled the storage of memories presumably through actin-capping activity. In support of the C. elegans results, genetic variability of the human ADD1 gene was significantly associated with episodic memory performance in healthy young subjects. Finally, human ADD1 expression in nematodes restored loss of C. elegans add-1 gene function. Taken together, our findings support a role for α-adducin in memory from nematodes to humans. Studying the molecular and genetic underpinnings of memory across distinct species may be helpful in the development of novel strategies to treat memory-related diseases. PMID:22307086

  3. Proposed sale of Parcel A2 of the Oak Ridge Reservation to the City of Oak Ridge, Tennessee

    SciTech Connect

    Not Available

    1992-09-01

    Parcel A encompasses two tracts of land owned by the US Department of Energy (DOE) on the Oak Ridge Reservation (ORR). The disposal of land was recommended by a General Services Administration 1981 land utilization survey. On June 21, 1988, 21.3 ha (52.7 acres) of land, Parcel A1, were transferred to the City of Oak Ridge. Parcel Al has since been transferred to the private sector for residential development. The City of Oak Ridge has requested acquisition of Parcel A2 for residential and industrial development. The purpose of the proposed action is to transfer Parcel A2 to the City of Oak Ridge for residential and industrial development. The need for the proposed action is for DOE to respond to the General Services Administration directive to dispose of Parcel A2 and to respond to the request by the City of Oak Ridge for its acquisition and development. The proposed sale of Parcel A2 would have no environmental impacts; however, the subsequent development by the City would affect the existing environment. It is the potential effects of the City's development of Parcel A2 that are addressed by this environmental assessment (EA). Areas of concern include land use, air quality, hydrology and water quality, wetlands and floodplains, ecological resources, and socioeconomic resources.

  4. Proposed sale of Parcel A2 of the Oak Ridge Reservation to the City of Oak Ridge, Tennessee. Environmental asssessment

    SciTech Connect

    Not Available

    1992-09-01

    Parcel A encompasses two tracts of land owned by the US Department of Energy (DOE) on the Oak Ridge Reservation (ORR). The disposal of land was recommended by a General Services Administration 1981 land utilization survey. On June 21, 1988, 21.3 ha (52.7 acres) of land, Parcel A1, were transferred to the City of Oak Ridge. Parcel Al has since been transferred to the private sector for residential development. The City of Oak Ridge has requested acquisition of Parcel A2 for residential and industrial development. The purpose of the proposed action is to transfer Parcel A2 to the City of Oak Ridge for residential and industrial development. The need for the proposed action is for DOE to respond to the General Services Administration directive to dispose of Parcel A2 and to respond to the request by the City of Oak Ridge for its acquisition and development. The proposed sale of Parcel A2 would have no environmental impacts; however, the subsequent development by the City would affect the existing environment. It is the potential effects of the City`s development of Parcel A2 that are addressed by this environmental assessment (EA). Areas of concern include land use, air quality, hydrology and water quality, wetlands and floodplains, ecological resources, and socioeconomic resources.

  5. GraSP: Geodesic Graph-based Segmentation With Shape Priors for the Functional Parcellation of the Cortex

    PubMed Central

    Honnorat, N.; Eavani, H.; Satterthwaite, T. D.; Gur, R. E.; Gur, R. C.; Davatzikos, C.

    2014-01-01

    Resting-state functional MRI is a powerful technique for mapping the functional organization of the human brain. However, for many types of connectivity analysis, high-resolution voxelwise analyses are computationally infeasible and dimensionality reduction is typically used to limit the number of network nodes. Most commonly, network nodes are defined using standard anatomic atlases that do not align well with functional neuroanatomy or regions of interest covering a small portion of the cortex. Data-driven parcellation methods seek to overcome such limitations, but existing approaches are highly dependent on initialization procedures and produce spatially fragmented parcels or overly isotropic parcels that are unlikely to be biologically grounded. In this paper, we propose a novel graph-based parcellation method that relies on a discrete Markov Random Field framework. The spatial connectedness of the parcels is explicitly enforced by shape priors. The shape of the parcels is adapted to underlying data through the use of functional geodesic distances. Our method is initialization-free and rapidly segments the cortex in a single optimization. The performance of the method was assessed using a large developmental cohort of more than 850 subjects. Compared to two prevalent parcellation methods, our approach provides superior reproducibility for a similar data fit. Furthermore, compared to other methods, it avoids incoherent parcels. Finally, the method’s utility is demonstrated through its ability to detect strong brain developmental effects that are only weakly observed using other methods. PMID:25462796

  6. 25 CFR 166.303 - Can more than one parcel of Indian land be combined into one permit?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Can more than one parcel of Indian land be combined into one permit? 166.303 Section 166.303 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER GRAZING PERMITS Land and Operations Management § 166.303 Can more than one parcel of...

  7. GraSP: geodesic Graph-based Segmentation with Shape Priors for the functional parcellation of the cortex.

    PubMed

    Honnorat, N; Eavani, H; Satterthwaite, T D; Gur, R E; Gur, R C; Davatzikos, C

    2015-02-01

    Resting-state functional MRI is a powerful technique for mapping the functional organization of the human brain. However, for many types of connectivity analysis, high-resolution voxelwise analyses are computationally infeasible and dimensionality reduction is typically used to limit the number of network nodes. Most commonly, network nodes are defined using standard anatomic atlases that do not align well with functional neuroanatomy or regions of interest covering a small portion of the cortex. Data-driven parcellation methods seek to overcome such limitations, but existing approaches are highly dependent on initialization procedures and produce spatially fragmented parcels or overly isotropic parcels that are unlikely to be biologically grounded. In this paper, we propose a novel graph-based parcellation method that relies on a discrete Markov Random Field framework. The spatial connectedness of the parcels is explicitly enforced by shape priors. The shape of the parcels is adapted to underlying data through the use of functional geodesic distances. Our method is initialization-free and rapidly segments the cortex in a single optimization. The performance of the method was assessed using a large developmental cohort of more than 850 subjects. Compared to two prevalent parcellation methods, our approach provides superior reproducibility for a similar data fit. Furthermore, compared to other methods, it avoids incoherent parcels. Finally, the method's utility is demonstrated through its ability to detect strong brain developmental effects that are only weakly observed using other methods.

  8. 9 CFR 325.2 - Parcel post and ferries deemed carriers.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Parcel post and ferries deemed carriers. 325.2 Section 325.2 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF... to transportation by ferry of any products loaded on a truck or other vehicle, or otherwise moved...

  9. 76 FR 13000 - Transfer of Commercial First-Class Mail Parcels to Competitive Product List

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-09

    ... From the Federal Register Online via the Government Publishing Office POSTAL SERVICE Transfer of Commercial First-Class Mail Parcels to Competitive Product List AGENCY: Postal Service.\\TM\\ ACTION: Notice. SUMMARY: The Postal Service hereby provides notice that it has filed a request with the Postal...

  10. Archaeological Survey of 56 Preselected Parcels on the AridLands Ecology Reserve

    SciTech Connect

    J. J. Sharpe.

    1999-04-22

    An archaeological survey of 56 preselected parcels on the Fitzner-Eberhardt Arid Lands Ecology (ALE) Reserve was undertaken in support of compensatory mitigation for the construction of the Environmental Restoration Disposal Facility (ERDF) cells 3 and 4 on the Hanford Site. This report presents the findings of the archaeological survey.

  11. 76 FR 77856 - International Mail Price Change for Inbound Air Parcel Post

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-14

    ... service bonus eligibility and submission of annual inflation information from the Consumer Price Index for... may qualify for percentage ``bonuses'' to their base rate based upon their provision of certain value... International Bureau publishes an annual notice establishing the postal administration's parcel rates for...

  12. Patients' preferences for treatment outcomes of add-on antiepileptic drugs: a conjoint analysis.

    PubMed

    Manjunath, Ranjani; Yang, Jui-Chen; Ettinger, Alan B

    2012-08-01

    To understand the relative importance of the outcomes of add-on antiepileptic drugs (AEDs) and the willingness of patients with epilepsy to accept therapeutic trade-offs between seizure control and tolerability, we administered a Web-enabled, choice-format conjoint survey to patients with a self-reported physician diagnosis of epilepsy and symptoms of partial seizures. Patients answered nine choice questions to evaluate treatment outcomes of two different hypothetical add-on AEDs. Patients were first asked to choose the better of the two medicines and then asked a follow-up question about whether or not they would add the selected AED to their current treatment regimen. Our study demonstrated that patients with epilepsy consider seizure reduction to be the top priority when ranking it against the reduction or elimination of side effects. This study aids in better understanding of patients' AED treatment preferences and may aid in management of epilepsy.

  13. Discovering Focus: Helping Students with ADD (Attention Deficit Disorder)

    ERIC Educational Resources Information Center

    Valkenburg, Jim

    2012-01-01

    Attention Deficit Disorder (ADD) is a neurological disorder which effects learning and that has a confusing set of diagnostic symptoms and an even more confusing set of remedies ranging from medication to meditation to nothing at all. Current neurological research suggests, however, that there are strategies that the individual with ADD can use to…

  14. Social Capital: Does It Add to the Health Inequalities Debate?

    ERIC Educational Resources Information Center

    Chappell, Neena L.; Funk, Laura M.

    2010-01-01

    This paper empirically examines the relationship between advantage, social capital and health status to assess (a) whether social capital adds explanatory power to what we already know about the relationship between advantage and health and (b) whether social capital adds anything beyond its component parts, namely social participation and trust.…

  15. Real-Time Access to Meteosat Data Using the ADDE Server Technology

    NASA Astrophysics Data System (ADS)

    Koenig, M.; Gaertner, V. K.

    2006-05-01

    The McIDAS ADDE technology is used by EUMETSAT to provide access to real-time Meteosat-8 image data to globally foster training activities within and outside classroom courses. (McIDAS - Man computer Interactive Data Access System, ADDE - Abstract Data Distribution Environment). The advanced imaging capabilities of Meteosat-8 - a satellite of the Meteosat Second Generation series - provides full disk Earth coverage in 11 spectral channels every 15 minutes. A further 12th channel covers the land surfaces in a 1 km spatial resolution in a solar wavelength. Real-time operational services use the EUMETCast dissemination mechanism for timely access to the image data. EUMETCast covers the geographic area of Europe, Africa, South America and parts of North America and Asia. Details of the EUMETCast system are given in a separate presentation by Gaertner and Koenig in this conference. In addition to EUMETCast, however, for training purposes, access is also made available in near real-time on the basis of the ADDE technology. This is an internet based data access, i.e. it is globally available. ADDE offers the possibility to retrieve only the area of interest, e.g. a special geographic area and only selected channels. This implies that the actual data transfer is small so that the internet is used very efficiently. ADDE was developed as part of the McIDAS software, and is now also freely available in the OpenADDE package (http://www.ssec.wisc.edu/mcidas/software/openadde). Other than McIDAS itself, there is a variety of application packages that are ADDE enabled, as e.g. McIDAS-Lite, the Unidata Integrated Data Viewer, Hydra, IDL, or Matlab. These tools also offer further analysis concepts. Examples will be shown during the presentation. The user community of the ADDE access also needs to be licensed according to the EUMETSAT data policy. After the successful commissioning of Meteosat-9, the data of this satellite will of course be incorporated into the ADDE data provision.

  16. 40 CFR 63.9323 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... the add-on control device simultaneously, using either Method 25 or 25A of appendix A to 40 CFR part... both the inlet and outlet measurements. (1) Use Method 25 of appendix A to 40 CFR part 60 if the add-on.... (1) Use Method 1 or 1A of appendix A to 40 CFR part 60, as appropriate, to select sampling sites...

  17. Predictive Capabilities of a Relaxation Model for Parcel-Based Granular Flow Simulations

    NASA Astrophysics Data System (ADS)

    Radl, Stefan; Sundaresan, Sankaran

    2011-11-01

    Parcel-based methods have a great potential to reduce the computational cost of particle simulations for dense flows. Here we investigate a relaxation model, similar to that of Bhatnagar-Gross-Krook (BGK), when applied to such a parcel-based simulation method. Specifically, we have chosen the simulation methodology initially proposed by Patankar and Joseph, and combined it with the relaxation model published by O'Rourke and Snider. We show that a relaxation model is key to correctly predicting macroscopic flow features, e.g., the scattering pattern of a granular jet impinging on a flat surface, studied experimentally by Cheng et al.. Simple shear flow simulations reveal that calculation of the locally-averaged velocity is a critical ingredient to correctly predict streaming and collisional stresses. SR acknowledges the support of the Austrian Science Foundation through the Erwin-Schroedinger fellowship J-3072.

  18. Multi-Contrast Multi-Atlas Parcellation of Diffusion Tensor Imaging of the Human Brain

    PubMed Central

    Tang, Xiaoying; Yoshida, Shoko; Hsu, John; Huisman, Thierry A. G. M.; Faria, Andreia V.; Oishi, Kenichi; Kutten, Kwame; Poretti, Andrea; Li, Yue; Miller, Michael I.; Mori, Susumu

    2014-01-01

    In this paper, we propose a novel method for parcellating the human brain into 193 anatomical structures based on diffusion tensor images (DTIs). This was accomplished in the setting of multi-contrast diffeomorphic likelihood fusion using multiple DTI atlases. DTI images are modeled as high dimensional fields, with each voxel exhibiting a vector valued feature comprising of mean diffusivity (MD), fractional anisotropy (FA), and fiber angle. For each structure, the probability distribution of each element in the feature vector is modeled as a mixture of Gaussians, the parameters of which are estimated from the labeled atlases. The structure-specific feature vector is then used to parcellate the test image. For each atlas, a likelihood is iteratively computed based on the structure-specific vector feature. The likelihoods from multiple atlases are then fused. The updating and fusing of the likelihoods is achieved based on the expectation-maximization (EM) algorithm for maximum a posteriori (MAP) estimation problems. We first demonstrate the performance of the algorithm by examining the parcellation accuracy of 18 structures from 25 subjects with a varying degree of structural abnormality. Dice values ranging 0.8–0.9 were obtained. In addition, strong correlation was found between the volume size of the automated and the manual parcellation. Then, we present scan-rescan reproducibility based on another dataset of 16 DTI images – an average of 3.73%, 1.91%, and 1.79% for volume, mean FA, and mean MD respectively. Finally, the range of anatomical variability in the normal population was quantified for each structure. PMID:24809486

  19. Using geometrical, textural, and contextual information of land parcels for classification of detailed urban land use

    USGS Publications Warehouse

    Wu, S.-S.; Qiu, X.; Usery, E.L.; Wang, L.

    2009-01-01

    Detailed urban land use data are important to government officials, researchers, and businesspeople for a variety of purposes. This article presents an approach to classifying detailed urban land use based on geometrical, textural, and contextual information of land parcels. An area of 6 by 14 km in Austin, Texas, with land parcel boundaries delineated by the Travis Central Appraisal District of Travis County, Texas, is tested for the approach. We derive fifty parcel attributes from relevant geographic information system (GIS) and remote sensing data and use them to discriminate among nine urban land uses: single family, multifamily, commercial, office, industrial, civic, open space, transportation, and undeveloped. Half of the 33,025 parcels in the study area are used as training data for land use classification and the other half are used as testing data for accuracy assessment. The best result with a decision tree classification algorithm has an overall accuracy of 96 percent and a kappa coefficient of 0.78, and two naive, baseline models based on the majority rule and the spatial autocorrelation rule have overall accuracy of 89 percent and 79 percent, respectively. The algorithm is relatively good at classifying single-family, multifamily, commercial, open space, and undeveloped land uses and relatively poor at classifying office, industrial, civic, and transportation land uses. The most important attributes for land use classification are the geometrical attributes, particularly those related to building areas. Next are the contextual attributes, particularly those relevant to the spatial relationship between buildings, then the textural attributes, particularly the semivariance texture statistic from 0.61-m resolution images.

  20. Interim Project Results: United Parcel Service's Second-Generation Hybrid-Electric Delivery Vans (Fact Sheet)

    SciTech Connect

    Not Available

    2012-01-01

    This fact sheet describes the performance evaluation of United Parcel Service's second-generation hybrid-electric delivery vans. The Fleet Test and Evaluation Team at the National Renewable Energy Laboratory (NREL) is evaluating the 18-month, in-service performance of 11 of these vans along with 11 comparable conventional diesel vans operating in Minneapolis, Minnesota. As a complement to the field study, the team recently completed fuel economy and emissions testing at NREL's Renewable Fuels and Lubricants (ReFUEL) laboratory.

  1. Computational neuroanatomy using brain deformations: From brain parcellation to multivariate pattern analysis and machine learning.

    PubMed

    Davatzikos, Christos

    2016-10-01

    The past 20 years have seen a mushrooming growth of the field of computational neuroanatomy. Much of this work has been enabled by the development and refinement of powerful, high-dimensional image warping methods, which have enabled detailed brain parcellation, voxel-based morphometric analyses, and multivariate pattern analyses using machine learning approaches. The evolution of these 3 types of analyses over the years has overcome many challenges. We present the evolution of our work in these 3 directions, which largely follows the evolution of this field. We discuss the progression from single-atlas, single-registration brain parcellation work to current ensemble-based parcellation; from relatively basic mass-univariate t-tests to optimized regional pattern analyses combining deformations and residuals; and from basic application of support vector machines to generative-discriminative formulations of multivariate pattern analyses, and to methods dealing with heterogeneity of neuroanatomical patterns. We conclude with discussion of some of the future directions and challenges. PMID:27514582

  2. Computational neuroanatomy using brain deformations: From brain parcellation to multivariate pattern analysis and machine learning.

    PubMed

    Davatzikos, Christos

    2016-10-01

    The past 20 years have seen a mushrooming growth of the field of computational neuroanatomy. Much of this work has been enabled by the development and refinement of powerful, high-dimensional image warping methods, which have enabled detailed brain parcellation, voxel-based morphometric analyses, and multivariate pattern analyses using machine learning approaches. The evolution of these 3 types of analyses over the years has overcome many challenges. We present the evolution of our work in these 3 directions, which largely follows the evolution of this field. We discuss the progression from single-atlas, single-registration brain parcellation work to current ensemble-based parcellation; from relatively basic mass-univariate t-tests to optimized regional pattern analyses combining deformations and residuals; and from basic application of support vector machines to generative-discriminative formulations of multivariate pattern analyses, and to methods dealing with heterogeneity of neuroanatomical patterns. We conclude with discussion of some of the future directions and challenges.

  3. Parcellation in Left Lateral Parietal Cortex Is Similar in Adults and Children

    PubMed Central

    Nelson, Steven M.; Cohen, Alexander L.; Power, Jonathan D.; Coalson, Rebecca S.; Miezin, Francis M.; Vogel, Alecia C.; Dubis, Joseph W.; Church, Jessica A.; Petersen, Steven E.; Schlaggar, Bradley L.

    2012-01-01

    A key question in developmental neuroscience involves understanding how and when the cerebral cortex is partitioned into distinct functional areas. The present study used functional connectivity MRI mapping and graph theory to identify putative cortical areas and generate a parcellation scheme of left lateral parietal cortex (LLPC) in 7 to 10-year-old children and adults. Results indicated that a majority of putative LLPC areas could be matched across groups (mean distance between matched areas across age: 3.15 mm). Furthermore, the boundaries of children's putative LLPC areas respected the boundaries generated from the adults' parcellation scheme for a majority of children's areas (13/15). Consistent with prior research, matched LLPC areas showed age-related differences in functional connectivity strength with other brain regions. These results suggest that LLPC cortical parcellation and functional connectivity mature along different developmental trajectories, with adult-like boundaries between LLPC areas established in school-age children prior to adult-like functional connectivity. PMID:21810781

  4. Top 5 Ways to Help Students with ADD/ADHD

    ERIC Educational Resources Information Center

    Johnson, Kathy

    2011-01-01

    This article suggests five ways to help students with ADD/ADHD. These are: (1) Integrate the primitive reflexes; (2) Diet; (3) Visual attention; (4) Help for auditory attention; and (5) Cognitive training.

  5. TDRS-K to Add to Vital Space Network

    NASA Video Gallery

    NASA officials discuss the launch of the TDRS-K spacecraft to add to the space network that enables communications between the International Space Station and Earth-orbiting satellites and ground c...

  6. Drell-Yan, , production in SM & ADD model to NLOPS accuracy at the LHC

    NASA Astrophysics Data System (ADS)

    Frederix, R.; Mandal, M. K.; Mathews, P.; Ravindran, V.; Seth, S.

    2014-02-01

    In this paper, we present the next-to-leading order QCD corrections for di-lepton, di-electroweak boson (, ) production in both the SM and the ADD model, matched to the HERWIG parton shower using the aMC@NLO framework. A selection of results at the 8 TeV LHC, which exhibit deviations from the SM as a result of the large extra-dimension scenario, are presented.

  7. Green infrastructure retrofits on residential parcels: Ecohydrologic modeling for stormwater design

    NASA Astrophysics Data System (ADS)

    Miles, B.; Band, L. E.

    2014-12-01

    To meet water quality goals stormwater utilities and not-for-profit watershed organizations in the U.S. are working with citizens to design and implement green infrastructure on residential land. Green infrastructure, as an alternative and complement to traditional (grey) stormwater infrastructure, has the potential to contribute to multiple ecosystem benefits including stormwater volume reduction, carbon sequestration, urban heat island mitigation, and to provide amenities to residents. However, in small (1-10-km2) medium-density urban watersheds with heterogeneous land cover it is unclear whether stormwater retrofits on residential parcels significantly contributes to reduce stormwater volume at the watershed scale. In this paper, we seek to improve understanding of how small-scale redistribution of water at the parcel scale as part of green infrastructure implementation affects urban water budgets and stormwater volume across spatial scales. As study sites we use two medium-density headwater watersheds in Baltimore, MD and Durham, NC. We develop ecohydrology modeling experiments to evaluate the effectiveness of redirecting residential rooftop runoff to un-altered pervious surfaces and to engineered rain gardens to reduce stormwater runoff. As baselines for these experiments, we performed field surveys of residential rooftop hydrologic connectivity to adjacent impervious surfaces, and found low rates of connectivity. Through simulations of pervasive adoption of downspout disconnection to un-altered pervious areas or to rain garden stormwater control measures (SCM) in these catchments, we find that most parcel-scale changes in stormwater fate are attenuated at larger spatial scales and that neither SCM alone is likely to provide significant changes in streamflow at the watershed scale.

  8. Method for combining information from white matter fiber tracking and gray matter parcellation.

    PubMed

    Park, Hae-Jeong; Kubicki, Marek; Westin, Carl-Fredrik; Talos, Ion-Florin; Brun, Anders; Peiper, Steve; Kikinis, Ron; Jolesz, Ference A; McCarley, Robert W; Shenton, Martha E

    2004-09-01

    We introduce a method for combining fiber tracking from diffusion-tensor (DT) imaging with cortical gray matter parcellation from structural high-spatial-resolution 3D spoiled gradient-recalled acquisition in the steady state images. We applied this method to a tumor case to determine the impact of the tumor on white matter architecture. We conclude that this new method for combining structural and DT imaging data is useful for understanding cortical connectivity and the localization of fiber tracts and their relationship with cortical anatomy and brain abnormalities.

  9. In situ observations of dehydrated air parcels advected horizontally in the Tropical Tropopause Layer of the western Pacific

    NASA Astrophysics Data System (ADS)

    Hasebe, F.; Fujiwara, M.; Nishi, N.; Shiotani, M.; Vömel, H.; Oltmans, S.; Takashima, H.; Saraspriya, S.; Komala, N.; Inai, Y.

    2007-02-01

    Water vapor observations by chilled-mirror hygrometers were conducted at Bandung, Indonesia (6.90° S, 107.60° E) and Tarawa, Kiribati (1.35° N, 172.91° E) in December 2003 to examine the efficiency of dehydration during horizontal advection in the tropical tropopause layer (TTL). Trajectory analyses based on bundles of isentropic trajectories suggest that the modification of air parcels' identity due to irreversible mixing by the branching-out and merging-in of nearby trajectories is found to be an important factor, in addition to the routes air parcels follow, for interpreting the water vapor concentrations observed by chilled-mirror frostpoint hygrometers in the TTL. Clear correspondence between the observed water vapor concentration and the estimated temperature history of air parcels is found showing that drier air parcels were exposed to lower temperatures than were more humid ones during advection. Although the number of observations is quite limited, the water content in the observed air parcels on many occasions was more than that expected from the minimum saturation mixing ratio during horizontal advection prior to sonde observations.

  10. Bidirectional iterative parcellation of diffusion weighted imaging data: Separating cortical regions connected by the arcuate fasciculus and extreme capsule

    PubMed Central

    Patterson, Dianne K.; Van Petten, Cyma; Beeson, Pélagie M.; Rapcsak, Steven Z.; Plante, Elena

    2014-01-01

    This paper introduces a Bidirectional Iterative Parcellation (BIP) procedure designed to identify the location and size of connected cortical regions (parcellations) at both ends of a white matter tract in diffusion weighted images. The procedure applies the FSL option “probabilistic tracking with classification targets” in a bidirectional and iterative manner. To assess the utility of BIP, we applied the procedure to the problem of parcellating a limited set of well-established gray matter seed regions associated with the dorsal (arcuate fasciculus/superior longitudinal fasciculus) and ventral (extreme capsule fiber system) white matter tracts in the language networks of 97 participants. These left hemisphere seed regions and the two white matter tracts, along with their right hemisphere homologues, provided an excellent test case for BIP because the resulting parcellations overlap and their connectivity via the arcuate fasciculi and extreme capsule fiber systems are well studied. The procedure yielded both confirmatory and novel findings. Specifically, BIP confirmed that each tract connects within the seed regions in unique, but expected ways. Novel findings included increasingly left-lateralized parcellations associated with the arcuate fasciculus/superior longitudinal fasciculus as a function of age and education. These results demonstrate that BIP is an easily implemented technique that successfully confirmed cortical connectivity patterns predicted in the literature, and has the potential to provide new insights regarding the architecture of the brain. PMID:25173414

  11. Joint Spectral Decomposition for the Parcellation of the Human Cerebral Cortex Using Resting-State fMRI.

    PubMed

    Arslan, Salim; Parisot, Sarah; Rueckert, Daniel

    2015-01-01

    Identification of functional connections within the human brain has gained a lot of attention due to its potential to reveal neural mechanisms. In a whole-brain connectivity analysis, a critical stage is the computation of a set of network nodes that can effectively represent cortical regions. To address this problem, we present a robust cerebral cortex parcellation method based on spectral graph theory and resting-state fMRI correlations that generates reliable parcellations at the single-subject level and across multiple subjects. Our method models the cortical surface in each hemisphere as a mesh graph represented in the spectral domain with its eigenvectors. We connect cortices of different subjects with each other based on the similarity of their connectivity profiles and construct a multi-layer graph, which effectively captures the fundamental properties of the whole group as well as preserves individual subject characteristics. Spectral decomposition of this joint graph is used to cluster each cortical vertex into a subregion in order to obtain whole-brain parcellations. Using rs-fMRI data collected from 40 healthy subjects, we show that our proposed algorithm computes highly reproducible parcellations across different groups of subjects and at varying levels of detail with an average Dice score of 0.78, achieving up to 9% better reproducibility compared to existing approaches. We also report that our group-wise parcellations are functionally more consistent, thus, can be reliably used to represent the population in network analyses.

  12. Functional Connectivity-Based Parcellation of Amygdala Using Self-Organized Mapping: A Data Driven Approach

    PubMed Central

    Mishra, Arabinda; Rogers, Baxter P.; Chen, Li Min; Gore, John C.

    2013-01-01

    The overall goal of this work is to demonstrate how resting state functional magnetic resonance imaging (fMRI) signals may be used to objectively parcellate functionally heterogeneous subregions of the human amygdala into structures characterized by similar patterns of functional connectivity. We hypothesize that similarity of functional connectivity of subregions with other parts of the brain can be a potential basis to segment and cluster voxels using data driven approaches. In this work, self-organizing map (SOM) was implemented to cluster the connectivity maps associated with each voxel of the human amygdala, thereby defining distinct subregions. The functional separation was optimized by evaluating the overall differences in functional connectivity between the subregions at group level. Analysis of 25 resting state fMRI data sets suggests that SOM can successfully identify functionally independent nuclei based on differences in their inter subregional functional connectivity, evaluated statistically at various confidence levels. Although amygdala contains several nuclei whose distinct roles are implicated in various functions, our objective approach discerns at least two functionally distinct volumes comparable to previous parcellation results obtained using probabilistic tractography and cytoarchitectonic analysis. Association of these nuclei with various known functions and a quantitative evaluation of their differences in overall functional connectivity with lateral orbital frontal cortex and temporal pole confirms the functional diversity of amygdala. The data driven approach adopted here may be used as a powerful indicator of structure–function relationships in the amygdala and other functionally heterogeneous structures as well. PMID:23418140

  13. Bystanders, parcelling, and an absence of trust in the grooming interactions of wild male chimpanzees.

    PubMed

    Kaburu, Stefano S K; Newton-Fisher, Nicholas E

    2016-01-01

    The evolution of cooperation remains a central issue in socio-biology with the fundamental problem of how individuals minimize the risks of being short-changed ('cheated') should their behavioural investment in another not be returned. Economic decisions that individuals make during interactions may depend upon the presence of potential partners nearby, which offers co operators a temptation to defect from the current partner. The parcelling model posits that donors subdivide services into parcels to force cooperation, and that this is contingent on opportunities for defection; that is, the presence of bystanders. Here we test this model and the effect of bystander presence using grooming interactions of wild chimpanzees. We found that with more bystanders, initiators gave less grooming at the beginning of the bout and were more likely to abandon a grooming bout, while bouts were less likely to be reciprocated. We also found that the groomer's initial investment was not higher among frequent groomers or stronger reciprocators, suggesting that contrary to current assumptions, grooming decisions are not based on trust, or bonds, within dyads. Our work highlights the importance of considering immediate social context and the influence of bystanders for understanding the evolution of the behavioural strategies that produce cooperation. PMID:26856371

  14. Bystanders, parcelling, and an absence of trust in the grooming interactions of wild male chimpanzees

    PubMed Central

    Kaburu, Stefano S. K.; Newton-Fisher, Nicholas E.

    2016-01-01

    The evolution of cooperation remains a central issue in socio-biology with the fundamental problem of how individuals minimize the risks of being short-changed (‘cheated’) should their behavioural investment in another not be returned. Economic decisions that individuals make during interactions may depend upon the presence of potential partners nearby, which offers co operators a temptation to defect from the current partner. The parcelling model posits that donors subdivide services into parcels to force cooperation, and that this is contingent on opportunities for defection; that is, the presence of bystanders. Here we test this model and the effect of bystander presence using grooming interactions of wild chimpanzees. We found that with more bystanders, initiators gave less grooming at the beginning of the bout and were more likely to abandon a grooming bout, while bouts were less likely to be reciprocated. We also found that the groomer’s initial investment was not higher among frequent groomers or stronger reciprocators, suggesting that contrary to current assumptions, grooming decisions are not based on trust, or bonds, within dyads. Our work highlights the importance of considering immediate social context and the influence of bystanders for understanding the evolution of the behavioural strategies that produce cooperation. PMID:26856371

  15. Uncertainty and dispersion in air parcel trajectories near the tropical tropopause

    NASA Astrophysics Data System (ADS)

    Bergman, John; Jensen, Eric; Pfister, Leonhard; Bui, Thoapaul

    2016-04-01

    The Tropical Tropopause Layer (TTL) is important as the gateway to the stratosphere for chemical constituents produced at the Earth's surface. As such, understanding the processes that transport air through the upper tropical troposphere is important for a number of current scientific issues such as the impact of stratospheric water vapor on the global radiative budget and the depletion of ozone by both anthropogenically- and naturally-produced halocarbons. Compared to the lower troposphere, transport in the TTL is relatively unaffected by turbulent motion. Consequently, Lagrangian particle models are thought to provide reasonable estimates of parcel pathways through the TTL. However, there are complications that make trajectory analyses difficult to interpret; uncertainty in the wind data used to drive these calculations and trajectory dispersion being among the most important. These issues are examined using ensembles of backward air parcel trajectories that are initially tightly grouped near the tropical tropopause using three approaches: A Monte Carlo ensemble, in which different members use identical resolved wind fluctuations but different realizations of stochastic, multi-fractal simulations of unresolved winds, perturbed initial location ensembles, in which members use identical resolved wind fields but initial locations are displaced 2° in latitude and longitude, and a multi-model ensemble that uses identical initial conditions but different resolved wind fields and/or trajectory formulations. Comparisons among the approaches distinguish, to some degree, physical dispersion from that due to data uncertainty and the impact of unresolved wind fluctuations from that of resolved variability.

  16. Stealing time. Time management techniques add hours to each day.

    PubMed

    Davis, Nadinia

    2003-06-01

    Time not only flies when we're having fun, but also when we're filing paperwork, checking e-mail, and looking for our car keys. But you can add hours to your day by managing yourself rather than time. Here's how.

  17. Enhancing Teaching using MATLAB Add-Ins for Excel

    ERIC Educational Resources Information Center

    Hamilton, Paul V.

    2004-01-01

    In this paper I will illustrate how to extend the capabilities of Microsoft Excel spreadsheets with add-ins created by MATLAB. Excel provides a broad array of fundamental tools but often comes up short when more sophisticated scenarios are involved. To overcome this short-coming of Excel while retaining its ease of use, I will describe how…

  18. Mode-routed fiber-optic add-drop filter

    NASA Technical Reports Server (NTRS)

    Moslehi, Behzad (Inventor); Black, Richard James (Inventor); Shaw, Herbert John (Inventor)

    2000-01-01

    New elements mode-converting two-mode grating and mode-filtering two-mode coupler are disclosed and used as elements in a system for communications, add-drop filtering, and strain sensing. Methods of fabrication for these new two-mode gratings and mode-filtering two-mode couplers are also disclosed.

  19. Medicalised Pupils: The Case of ADD/ADHD

    ERIC Educational Resources Information Center

    Kristjansson, Kristjan

    2009-01-01

    Recent decades have seen an increasing number of life's problems conceptualised and interpreted through the prism of disease; among them are those affecting pupils at school. Witness the cases of hyperactivity and deficient attention, so often diagnosed as ADD/ADHD. Research indicates that there is at least some tendency towards overdiagnosis of…

  20. The Care Tradition: Beyond "Add Women and Stir."

    ERIC Educational Resources Information Center

    Noddings, Nel

    2001-01-01

    Examines problems of curricular inclusion, emphasizing ways of including the interests and contributions of women in social studies curricula. After describing the inadequacy of the "add women and stir" approach to inclusion, the paper discusses the tradition of care long identified with female life, then explores ways to preserve and extend this…

  1. New particle-dependent parameterizations of heterogeneous freezing processes: sensitivity studies of convective clouds with an air parcel model

    NASA Astrophysics Data System (ADS)

    Diehl, K.; Mitra, S. K.

    2015-11-01

    Based on the outcome of laboratory results, new particle-dependent parameterizations of heterogeneous freezing were derived and used to improve and extend a two-dimensional spectral microphysics scheme. They include (1) a particle-type-dependent parameterization of immersion freezing using the numbers of active sites per mass, (2) a particle-type and size-resolved parameterization of contact freezing, and (3) a particle-type-dependent description of deposition freezing. The modified microphysical scheme was embedded in an adiabatic air parcel model with entrainment. Sensitivity studies were performed to simulate convective situations and to investigate the impact of ice nuclei concentrations and types on ice formation. As a central diagnostic parameter, the ice water fraction (IWF) was selected, which is the relation of the ice water content to the total amount of water in the condensed form. The following parameters were varied: initial aerosol particle number size distributions, types of ice nucleating particles, final temperature, and the fractions of potential ice nucleating particles. Single and coupled freezing processes were investigated. The results show that immersion freezing seems to be the most efficient process. Contact freezing is constrained by the collision kernel between supercooled drops and potential ice nucleating particles. The importance of deposition freezing lies in secondary ice formation; i.e., small ice particles produced by deposition nucleation trigger the freezing of supercooled drops by collisions. Thus, a broader ice particle spectrum is generated than that by immersion and contact freezing. During coupled immersion-contact and contact-deposition freezing no competition was observed, and both processes contribute to cloud ice formation but do not impede each other. As already suggested in the literature, mineral dust particles seem to be the most important ice nucleating particles. Biological particles are probably not involved in

  2. 27 CFR 44.225 - Delivery of tobacco products, or cigarette papers or tubes for export other than by parcel post.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... products, or cigarette papers or tubes for export other than by parcel post. 44.225 Section 44.225 Alcohol... (CONTINUED) TOBACCO EXPORTATION OF TOBACCO PRODUCTS AND CIGARETTE PAPERS AND TUBES, WITHOUT PAYMENT OF TAX... tubes for export other than by parcel post. The claimant, upon release of the tobacco products,...

  3. 27 CFR 44.225 - Delivery of tobacco products, or cigarette papers or tubes for export other than by parcel post.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... products, or cigarette papers or tubes for export other than by parcel post. 44.225 Section 44.225 Alcohol... (CONTINUED) TOBACCO EXPORTATION OF TOBACCO PRODUCTS AND CIGARETTE PAPERS AND TUBES, WITHOUT PAYMENT OF TAX... tubes for export other than by parcel post. The claimant, upon release of the tobacco products,...

  4. Add Control: plant virtualization for control solutions in WWTP.

    PubMed

    Maiza, M; Bengoechea, A; Grau, P; De Keyser, W; Nopens, I; Brockmann, D; Steyer, J P; Claeys, F; Urchegui, G; Fernández, O; Ayesa, E

    2013-01-01

    This paper summarizes part of the research work carried out in the Add Control project, which proposes an extension of the wastewater treatment plant (WWTP) models and modelling architectures used in traditional WWTP simulation tools, addressing, in addition to the classical mass transformations (transport, physico-chemical phenomena, biological reactions), all the instrumentation, actuation and automation & control components (sensors, actuators, controllers), considering their real behaviour (signal delays, noise, failures and power consumption of actuators). Its ultimate objective is to allow a rapid transition from the simulation of the control strategy to its implementation at full-scale plants. Thus, this paper presents the application of the Add Control simulation platform for the design and implementation of new control strategies at the WWTP of Mekolalde. PMID:23863420

  5. Stereovision Imaging in Smart Mobile Phone Using Add on Prisms

    NASA Astrophysics Data System (ADS)

    Bar-Magen Numhauser, Jonathan; Zalevsky, Zeev

    2014-03-01

    In this work we present the use of a prism-based add on component installed on top of a smart phone to achieve stereovision capabilities using iPhone mobile operating system. Through these components and the combination of the appropriate application programming interface and mathematical algorithms the obtained results will permit the analysis of possible enhancements for new uses to such system, in a variety of areas including medicine and communications.

  6. Family nurse practitioners: "value add" in outpatient chronic disease management.

    PubMed

    Stephens, Lynn

    2012-12-01

    Nurse practitioners are capable leaders in primary care design as practices nationwide move to consider and adopt the patient-centered medical home. The chronic care model provides a structure to enhance the care of chronic illness. Nurse practitioners are instrumental in many areas of this model as both leaders and caregivers. Safety and quality are basic medical home goals; nurse practitioners enhance both. The addition of a nurse practitioner to a practice is an effective "value add" in every way.

  7. 77 FR 54607 - Proclaiming Certain Lands, Sugar Parcel Lands, as an Addition to the Bay Mills Indian Reservation...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-05

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE INTERIOR Bureau of Indian Affairs Proclaiming Certain Lands, Sugar Parcel Lands, as an Addition to the Bay Mills Indian Reservation for the Bay Mills Indian Community of Michigan AGENCY: Bureau of Indian...

  8. Three Approaches to Using Lengthy Ordinal Scales in Structural Equation Models: Parceling, Latent Scoring, and Shortening Scales

    ERIC Educational Resources Information Center

    Yang, Chongming; Nay, Sandra; Hoyle, Rick H.

    2010-01-01

    Lengthy scales or testlets pose certain challenges for structural equation modeling (SEM) if all the items are included as indicators of a latent construct. Three general approaches to modeling lengthy scales in SEM (parceling, latent scoring, and shortening) have been reviewed and evaluated. A hypothetical population model is simulated containing…

  9. Investigating Historic Parcel Changes to Understand Land Use Trends: A Methodology and Application for the San Pedro River Watershed

    EPA Science Inventory

    Long-term land use and land cover change, and the associated impacts, pose critical challenges to sustaining healthy communities and ecosystems. In this study, a methodology was developed to use parcel data to evaluate land use trends in southeast Arizona’s San Pedro River Water...

  10. A Monte Carlo Study Investigating the Impact of Item Parceling Strategies on Parameter Estimates and Their Standard Errors in CFA

    ERIC Educational Resources Information Center

    Alhija, Fadia Nasser-Abu; Wisenbaker, Joseph

    2006-01-01

    A simulation study was conducted to examine the effect of item parceling on confirmatory factor analysis parameter estimates and their standard errors at different levels of sample size, number of indicators per factor, size of factor structure/pattern coefficients, magnitude of interfactor correlations, and variations in item-level data…

  11. 27 CFR 44.226 - Delivery of tobacco products, and cigarette papers and tubes for export by parcel post.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2014-04-01 2014-04-01 false Delivery of tobacco products, and cigarette papers and tubes for export by parcel post. 44.226 Section 44.226 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY...

  12. 27 CFR 44.226 - Delivery of tobacco products, and cigarette papers and tubes for export by parcel post.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2013-04-01 2013-04-01 false Delivery of tobacco products, and cigarette papers and tubes for export by parcel post. 44.226 Section 44.226 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY...

  13. 27 CFR 44.226 - Delivery of tobacco products, and cigarette papers and tubes for export by parcel post.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2012-04-01 2011-04-01 true Delivery of tobacco products, and cigarette papers and tubes for export by parcel post. 44.226 Section 44.226 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY...

  14. Three Approaches to Using Lengthy Ordinal Scales in Structural Equation Models: Parceling, Latent Scoring, and Shortening Scales

    PubMed Central

    Yang, Chongming; Nay, Sandra; Hoyle, Rick H.

    2009-01-01

    Lengthy scales or testlets pose certain challenges for structural equation modeling (SEM) if all the items are included as indicators of a latent construct. Three general approaches (parceling, latent scoring, and shortening) to modeling lengthy scales in SEM were reviewed and evaluated. A hypothetical population model was simulated containing two exogenous constructs with 14 indicators each and an endogenous construct with four indicators. The simulation generated data sets with varying numbers of response options, two types of distributions, factor loadings ranging from low to high, and sample sizes ranging from small to moderate. The population model was varied to incorporate one of the following: (1) single parcels, (2) various parcels as indicators of two exogenous constructs, (3) latent scores as observed exogenous variables, and (4) four and six of individual items as indicators of two exogenous constructs. The dependent variables evaluated were biases in the covariance and partial covariance population parameters. Biases in these parameters were found to be minimal under the following conditions: (1) when parcels of indicators of five response options were used as indicators of two latent exogenous constructs; (2) when latent scores were used as observed variables at sample sizes above 100 and with indicators that were relatively less skewed in the case of dichotomous indicators; and (3) when four or six individual items with high or diverse factor loadings were used as indicators of two exogenous constructs. These findings provided guidelines for resolving the inconsistency of findings from applying various approaches to empirical data. PMID:20514149

  15. The Impact of the Parcel-Level Land Architecture on Land Surface Temperature in the Phoenix Metropolitan Area

    NASA Astrophysics Data System (ADS)

    LI, X.; Ouyang, Y.; Turner, B. L., II; Harlan, S.; Brazel, A.

    2014-12-01

    The relationship between land surface temperature (LST) and characteristics of the urban land system has received increasing attention in urban heat island research, especially for desert cities. The relationship between the land composition and LST has been widely studied. Such researches generally employ medium or coarser spatial resolution remotely sensed data and primarily focuses on the effects of one land cover type on the LST. In this study, we explore the effects of land system architecture - composition and configuration of different land-cover classes - on LST in the central Arizona-Phoenix metropolitan area at a fine-scale resolution, focused on the composition and configuration of single family residential parcels. A 1 m resolution land-cover map is used to calculate landscape metrics at the parcel level, and 6.8 m resolution data from the MODIS/ASTER are employed to retrieve LST. We introduce the socio-economic factors at neighborhood level as explanatory variables to help control for potential neighborhood effects. Multiple linear regression models examine the effects of landscape configuration on LST at the parcel scale, controlling for the effects of landscape composition and neighborhood characteristics. Results show that the configuration of parcels affects LST, revealing significant variable relationships between that architecture and LST at nighttime and daytime, and the role of the neighborhood effects on the outcomes.

  16. 27 CFR 44.226 - Delivery of tobacco products, and cigarette papers and tubes for export by parcel post.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... products, and cigarette papers and tubes for export by parcel post. 44.226 Section 44.226 Alcohol, Tobacco...) TOBACCO EXPORTATION OF TOBACCO PRODUCTS AND CIGARETTE PAPERS AND TUBES, WITHOUT PAYMENT OF TAX, OR WITH DRAWBACK OF TAX Drawback of Tax § 44.226 Delivery of tobacco products, and cigarette papers and tubes...

  17. 27 CFR 44.226 - Delivery of tobacco products, and cigarette papers and tubes for export by parcel post.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... products, and cigarette papers and tubes for export by parcel post. 44.226 Section 44.226 Alcohol, Tobacco...) TOBACCO EXPORTATION OF TOBACCO PRODUCTS AND CIGARETTE PAPERS AND TUBES, WITHOUT PAYMENT OF TAX, OR WITH DRAWBACK OF TAX Drawback of Tax § 44.226 Delivery of tobacco products, and cigarette papers and tubes...

  18. 78 FR 56242 - Notice of Realty Action: Competitive Sale of 28 Parcels of Public Land in Clark County, NV

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-12

    ... Bureau of Land Management [LLNVS00560 L58530000 EU0000 241A; N-78190 et al.; 13-08807; MO 4500053642; TAS: 14X5232] Notice of Realty Action: Competitive Sale of 28 Parcels of Public Land in Clark County, NV AGENCY: Bureau of Land Management, Interior. ACTION: Notice of Realty Action. SUMMARY: The Bureau of...

  19. 43 CFR 2568.80 - Does the parcel have to be surveyed before I can receive title to it?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... I can receive title to it? 2568.80 Section 2568.80 Public Lands: Interior Regulations Relating to... § 2568.80 Does the parcel have to be surveyed before I can receive title to it? Yes. The land in your application must be surveyed before BLM can convey it to you. BLM will survey your allotment at no charge...

  20. 43 CFR 2568.80 - Does the parcel have to be surveyed before I can receive title to it?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... I can receive title to it? 2568.80 Section 2568.80 Public Lands: Interior Regulations Relating to... § 2568.80 Does the parcel have to be surveyed before I can receive title to it? Yes. The land in your application must be surveyed before BLM can convey it to you. BLM will survey your allotment at no charge...

  1. Add-on unidirectional elastic metamaterial plate cloak

    PubMed Central

    Lee, Min Kyung; Kim, Yoon Young

    2016-01-01

    Metamaterial cloaks control the propagation of waves to make an object invisible or insensible. To manipulate elastic waves in space, a metamaterial cloak is typically embedded in a base system that includes or surrounds a target object. The embedding is undesirable because it structurally weakens or permanently alters the base system. In this study, we propose a new add-on metamaterial elastic cloak that can be placed over and mechanically coupled with a base structure without embedding. We designed an add-on type annular metamaterial plate cloak through conformal mapping, fabricated it and performed cloaking experiments in a thin-plate with a hole. Experiments were performed in a thin plate by using the lowest symmetric Lamb wave centered at 100 kHz. As a means to check the cloaking performance of the add-on elastic plate cloak, possibly as a temporary stress reliever or a so-called “stress bandage”, the degree of stress concentration mitigation and the recovery from the perturbed wave field due to a hole were investigated. PMID:26860896

  2. Add-on unidirectional elastic metamaterial plate cloak.

    PubMed

    Lee, Min Kyung; Kim, Yoon Young

    2016-01-01

    Metamaterial cloaks control the propagation of waves to make an object invisible or insensible. To manipulate elastic waves in space, a metamaterial cloak is typically embedded in a base system that includes or surrounds a target object. The embedding is undesirable because it structurally weakens or permanently alters the base system. In this study, we propose a new add-on metamaterial elastic cloak that can be placed over and mechanically coupled with a base structure without embedding. We designed an add-on type annular metamaterial plate cloak through conformal mapping, fabricated it and performed cloaking experiments in a thin-plate with a hole. Experiments were performed in a thin plate by using the lowest symmetric Lamb wave centered at 100 kHz. As a means to check the cloaking performance of the add-on elastic plate cloak, possibly as a temporary stress reliever or a so-called "stress bandage", the degree of stress concentration mitigation and the recovery from the perturbed wave field due to a hole were investigated. PMID:26860896

  3. Optical add/drop filter for wavelength division multiplexed systems

    DOEpatents

    Deri, Robert J.; Strand, Oliver T.; Garrett, Henry E.

    2002-01-01

    An optical add/drop filter for wavelength division multiplexed systems and construction methods are disclosed. The add/drop filter includes a first ferrule having a first pre-formed opening for receiving a first optical fiber; an interference filter oriented to pass a first set of wavelengths along the first optical fiber and reflect a second set of wavelengths; and, a second ferrule having a second pre-formed opening for receiving the second optical fiber, and the reflected second set of wavelengths. A method for constructing the optical add/drop filter consists of the steps of forming a first set of openings in a first ferrule; inserting a first set of optical fibers into the first set of openings; forming a first set of guide pin openings in the first ferrule; dividing the first ferrule into a first ferrule portion and a second ferrule portion; forming an interference filter on the first ferrule portion; inserting guide pins through the first set of guide pin openings in the first ferrule portion and second ferrule portion to passively align the first set of optical fibers; removing material such that light reflected from the interference filter from the first set of optical fibers is accessible; forming a second set of openings in a second ferrule; inserting a second set of optical fibers into the second set of openings; and positioning the second ferrule with respect to the first ferrule such that the second set of optical fibers receive the light reflected from the interference filter.

  4. Add-on unidirectional elastic metamaterial plate cloak

    NASA Astrophysics Data System (ADS)

    Lee, Min Kyung; Kim, Yoon Young

    2016-02-01

    Metamaterial cloaks control the propagation of waves to make an object invisible or insensible. To manipulate elastic waves in space, a metamaterial cloak is typically embedded in a base system that includes or surrounds a target object. The embedding is undesirable because it structurally weakens or permanently alters the base system. In this study, we propose a new add-on metamaterial elastic cloak that can be placed over and mechanically coupled with a base structure without embedding. We designed an add-on type annular metamaterial plate cloak through conformal mapping, fabricated it and performed cloaking experiments in a thin-plate with a hole. Experiments were performed in a thin plate by using the lowest symmetric Lamb wave centered at 100 kHz. As a means to check the cloaking performance of the add-on elastic plate cloak, possibly as a temporary stress reliever or a so-called “stress bandage”, the degree of stress concentration mitigation and the recovery from the perturbed wave field due to a hole were investigated.

  5. Thalamus parcellation using multi-modal feature classification and thalamic nuclei priors

    NASA Astrophysics Data System (ADS)

    Glaister, Jeffrey; Carass, Aaron; Stough, Joshua V.; Calabresi, Peter A.; Prince, Jerry L.

    2016-03-01

    Segmentation of the thalamus and thalamic nuclei is useful to quantify volumetric changes from neurodegenerative diseases. Most thalamus segmentation algorithms only use T1-weighted magnetic resonance images and current thalamic parcellation methods require manual interaction. Smaller nuclei, such as the lateral and medial geniculates, are challenging to locate due to their small size. We propose an automated segmentation algorithm using a set of features derived from diffusion tensor image (DTI) and thalamic nuclei location priors. After extracting features, a hierarchical random forest classifier is trained to locate the thalamus. A second random forest classifies thalamus voxels as belonging to one of six thalamic nuclei classes. The proposed algorithm was tested using a leave-one-out cross validation scheme and compared with state-of-the-art algorithms. The proposed algorithm has a higher Dice score compared to other methods for the whole thalamus and several nuclei.

  6. Regional structural differences across functionally parcellated Brodmann areas of human primary somatosensory cortex.

    PubMed

    Sánchez-Panchuelo, Rosa-María; Besle, Julien; Mougin, Olivier; Gowland, Penny; Bowtell, Richard; Schluppeck, Denis; Francis, Susan

    2014-06-01

    Ultra-high-field (UHF) MRI is ideally suited for structural and functional imaging of the brain. High-resolution structural MRI can be used to map the anatomical boundaries between functional domains of the brain by identifying changes related to the pattern of myelination within cortical gray matter, opening up the possibility to study the relationship between functional domains and underlying structure in vivo. In a recent study, we demonstrated the correspondence between functional (based on retinotopic mapping) and structural (based on changes in T2(⁎)-weighted images linked to myelination) parcellations of the primary visual cortex (V1) in vivo at 7T (Sanchez-Panchuelo et al., 2012b). Here, we take advantage of the improved BOLD CNR and high spatial resolution achievable at 7T to study regional structural variations across the functionally defined areas within the primary somatosensory cortex (S1) in individual subjects. Using a traveling wave fMRI paradigm to map the internal somatotopic representation of the index, middle, and ring fingers in S1, we were able to identify multiple map reversals at the tip and base, corresponding to the boundaries between Brodmann areas 3a, 3b, 1 and 2. Based on high resolution structural MRI data acquired in the same subjects, we inspected these functionally-parcellated Brodmann areas for differences in cortical thickness and MR contrast measures (magnetization transfer ratio (MTR) and signal intensity in phase sensitive inversion recovery (PSIR) images) that are sensitive to myelination. Consistent area-related differences in cortical thickness and MTR/PSIR measurements were found across subjects. However these measures did not have sufficient sensitivity to allow definition of areal boundaries.

  7. 40 CFR 75.34 - Units with add-on emission controls.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Units with add-on emission controls... add-on emission controls. (a) The owner or operator of an affected unit equipped with add-on SO2 and... which the add-on emission controls are documented to be operating properly, as described in the...

  8. Image restoration by the shift-and-add algorithm.

    PubMed

    Bagnuolo, W G

    1985-05-01

    A new method for image restoration based on the shift-and-add (SAA) algorithm is presented, the main advantages of which appear to be speed and simplicity. The SAA pattern produced by an object is given by the object correlated by a nonlinear replica of itself whose intensity distribution is strongly weighted toward the brighter pixels. A method of successive substitutions analogous to Fienup's algorithm can then be used to decorrelate the SAA pattern and recover the object. The method is applied to the case of the extended chromosphere of Betelgeuse. PMID:19724393

  9. Using Patient Lists to Add Value to Integrated Data Repositories

    PubMed Central

    Wade, Ted D.; Zelarney, Pearlanne T.; Hum, Richard C.; McGee, Sylvia; Batson, Deborah H.

    2014-01-01

    Patient lists are project-specific sets of patients that can be queried in integrated data repositories (IDR’s). By allowing a set of patients to be an addition to the qualifying conditions of a query, returned results will refer to, and only to, that set of patients. We report a variety of use cases for such lists, including: restricting retrospective chart review to a defined set of patients; following a set of patients for practice management purposes; distributing “honest-brokered” (deidentified) data; adding phenotypes to biosamples; and enhancing the content of study or registry data. Among the capabilities needed to implement patient lists in an IDR are: capture of patient identifiers from a query and feedback of these into the IDR; the existence of a permanent internal identifier in the IDR that is mappable to external identifiers; the ability to add queryable attributes to the IDR; the ability to merge data from multiple queries; and suitable control over user access and de-identification of results. We implemented patient lists in a custom IDR of our own design. We reviewed capabilities of other published IDRs for focusing on sets of patients. The widely used i2b2 IDR platform has various ways to address patient sets, and it could be modified to add the low-overhead version of patient lists that we describe. PMID:24534444

  10. Connectivity-based whole brain dual parcellation by group ICA reveals tract structures and decreased connectivity in schizophrenia.

    PubMed

    Wu, Lei; Calhoun, Vince D; Jung, Rex E; Caprihan, Arvind

    2015-11-01

    Mapping brain connectivity based on neuroimaging data is a promising new tool for understanding brain structure and function. In this methods paper, we demonstrate that group independent component analysis (GICA) can be used to perform a dual parcellation of the brain based on its connectivity matrix (cmICA). This dual parcellation consists of a set of spatially independent source maps, and a corresponding set of paired dual maps that define the connectivity of each source map to the brain. These dual maps are called the connectivity profiles of the source maps. Traditional analysis of connectivity matrices has been used previously for brain parcellation, but the present method provides additional information on the connectivity of these segmented regions. In this paper, the whole brain structural connectivity matrices were calculated on a 5 mm(3) voxel scale from diffusion imaging data based on the probabilistic tractography method. The effect of the choice of the number of components (30 and 100) and their stability were examined. This method generated a set of spatially independent components that are consistent with the canonical brain tracts provided by previous anatomic descriptions, with the high order model yielding finer segmentations. The corpus-callosum example shows how this method leads to a robust parcellation of a brain structure based on its connectivity properties. We applied cmICA to study structural connectivity differences between a group of schizophrenia subjects and healthy controls. The connectivity profiles at both model orders showed similar regions with reduced connectivity in schizophrenia patients. These regions included forceps major, right inferior fronto-occipital fasciculus, uncinate fasciculus, thalamic radiation, and corticospinal tract. This paper provides a novel unsupervised data-driven framework that summarizes the information in a large global connectivity matrix and tests for brain connectivity differences. It has the

  11. Localization and quantification of intramuscular damage using statistical parametric mapping and skeletal muscle parcellation

    PubMed Central

    Fouré, Alexandre; Le Troter, Arnaud; Guye, Maxime; Mattei, Jean-Pierre; Bendahan, David; Gondin, Julien

    2015-01-01

    In the present study, we proposed an original and robust methodology which combines the spatial normalization of skeletal muscle images, the statistical parametric mapping (SPM) analysis and the use of a specific parcellation in order to accurately localize and quantify the extent of skeletal muscle damage within the four heads of the quadriceps femoris. T2 maps of thigh muscles were characterized before, two (D2) and four (D4) days after 40 maximal isometric electrically-evoked contractions in 25 healthy young males. On the basis of SPM analysis of coregistrated T2 maps, the alterations were similarly detected at D2 and D4 in the superficial and distal regions of the vastus medialis (VM) whereas the proportion of altered muscle was higher in deep muscle regions of the vastus lateralis at D4 (deep: 35 ± 25%, superficial: 23 ± 15%) as compared to D2 (deep: 18 ± 13%, superficial: 17 ± 13%). The present methodology used for the first time on skeletal muscle would be of utmost interest to detect subtle intramuscular alterations not only for the diagnosis of muscular diseases but also for assessing the efficacy of potential therapeutic interventions and clinical treatment strategies. PMID:26689827

  12. A comparison of working postures of parcel sorters using three different working methods.

    PubMed

    Derksen, J C; Van Riel, M P; Van Wingerden, J P; Snijders, C J

    1994-02-01

    The postures of the trunk of eight parcel sorters were measured continuously under three different working conditions, during whole shifts. The working methods used were two different sorting tables and a hydraulic lifting platform on which the carts were to be placed. The question posed by the PTT-Post occupational health service was whether the latter method proved to be the better one with respect to the load on the musculoskeletal system. This study will help them to make a well-considered decision on which working method to choose for the new distribution centre in Rotterdam. The method used for measuring the working postures and movements of the trunk is the Portable Posture Registration Set (PPRS). This method was developed at the department of Biomedical Physics and Technology of the Erasmus University Rotterdam. While using the lifting platform, the subjects stood 8-11% more erect compared to the work at the sorting tables, thereby reducing the load on the lumbar spine. For this reason the lifting platform is preferred, although sagittal flexion of the back was somewhat more. It is stressed that the way in which sorters use the lifting platform is very important. PMID:8119262

  13. Data model for the collaboration between land administration systems and agricultural land parcel identification systems.

    PubMed

    Inan, Halil Ibrahim; Sagris, Valentina; Devos, Wim; Milenov, Pavel; van Oosterom, Peter; Zevenbergen, Jaap

    2010-12-01

    The Common Agricultural Policy (CAP) of the European Union (EU) has dramatically changed after 1992, and from then on the CAP focused on the management of direct income subsidies instead of production-based subsidies. For this focus, Member States (MS) are expected to establish Integrated Administration and Control System (IACS), including a Land Parcel Identification System (LPIS) as the spatial part of IACS. Different MS have chosen different solutions for their LPIS. Currently, some MS based their IACS/LPIS on data from their Land Administration Systems (LAS), and many others use purpose built special systems for their IACS/LPIS. The issue with these different IACS/LPIS is that they do not have standardized structures; rather, each represents a unique design in each MS, both in the case of LAS based or special systems. In this study, we aim at designing a core data model for those IACS/LPIS based on LAS. For this purpose, we make use of the ongoing standardization initiatives for LAS (Land Administration Domain Model: LADM) and IACS/LPIS (LPIS Core Model: LCM). The data model we propose in this study implies the collaboration between LADM and LCM and includes some extensions. Some basic issues with the collaboration model are discussed within this study: registration of farmers, land use rights and farming limitations, geometry/topology, temporal data management etc. For further explanation of the model structure, sample instance level diagrams illustrating some typical situations are also included.

  14. 40 CFR 63.3966 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... simultaneously, using either Method 25 or 25A of appendix A to 40 CFR part 60. (1) Use Method 25 if the add-on... 1A of appendix A to 40 CFR part 60, as appropriate, to select sampling sites and velocity traverse points. (2) Use Method 2, 2A, 2C, 2D, 2F, or 2G of appendix A to 40 CFR part 60, as appropriate,...

  15. 40 CFR 63.3966 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... simultaneously, using either Method 25 or 25A of appendix A to 40 CFR part 60. (1) Use Method 25 if the add-on... 1A of appendix A to 40 CFR part 60, as appropriate, to select sampling sites and velocity traverse points. (2) Use Method 2, 2A, 2C, 2D, 2F, or 2G of appendix A to 40 CFR part 60, as appropriate,...

  16. Add-on laser reading device for a camera phone

    NASA Astrophysics Data System (ADS)

    Mäkinen, Jukka-Tapani; Niemelä, Karri; Vasama, Hannu; Mattila, Rauno; Aikio, Mika; Aikio, Sanna; Aikio, Janne

    2005-09-01

    A novel add-on device to a mobile camera phone has been developed. The prototype system contains both laser and LED illumination as well as imaging optics. Main idea behind the device is to have a small printable diffractive ROM (Read Only Memory) element, which can be read by illuminating it with a laser-beam and recording the resulting datamatrix pattern with a camera phone. The element contains information in the same manner as a traditional bar-code, but due to the 2D-pattern and diffractive nature of the tag, a much larger amount of information can be packed on a smaller area. Optical and mechanical designs of the prototype device have been made in such a way that the system can be used in three different modes: as a laser reader, as a telescope and as a microscope.

  17. A subsurface add-on for standard atomic force microscopes.

    PubMed

    Verbiest, G J; van der Zalm, D J; Oosterkamp, T H; Rost, M J

    2015-03-01

    The application of ultrasound in an Atomic Force Microscope (AFM) gives access to subsurface information. However, no commercially AFM exists that is equipped with this technique. The main problems are the electronic crosstalk in the AFM setup and the insufficiently strong excitation of the cantilever at ultrasonic (MHz) frequencies. In this paper, we describe the development of an add-on that provides a solution to these problems by using a special piezo element with a lowest resonance frequency of 2.5 MHz and by separating the electronic connection for this high frequency piezo element from all other connections. In this sense, we support researches with the possibility to perform subsurface measurements with their existing AFMs and hopefully pave also the way for the development of a commercial AFM that is capable of imaging subsurface features with nanometer resolution.

  18. A subsurface add-on for standard atomic force microscopes

    SciTech Connect

    Verbiest, G. J.; Zalm, D. J. van der; Oosterkamp, T. H.; Rost, M. J.

    2015-03-15

    The application of ultrasound in an Atomic Force Microscope (AFM) gives access to subsurface information. However, no commercially AFM exists that is equipped with this technique. The main problems are the electronic crosstalk in the AFM setup and the insufficiently strong excitation of the cantilever at ultrasonic (MHz) frequencies. In this paper, we describe the development of an add-on that provides a solution to these problems by using a special piezo element with a lowest resonance frequency of 2.5 MHz and by separating the electronic connection for this high frequency piezo element from all other connections. In this sense, we support researches with the possibility to perform subsurface measurements with their existing AFMs and hopefully pave also the way for the development of a commercial AFM that is capable of imaging subsurface features with nanometer resolution.

  19. How do I add my name to a mailing list?

    Atmospheric Science Data Center

    2015-10-28

    ... List Registration" - Select the project name - Enter email address - Enter the code that is in the image - Select "Subscribe"   ** You should receive an email to confirm your decision to subscribe. ** General ...

  20. Design and simulation of microring resonators for time-domain optical add-drop multiplexing

    NASA Astrophysics Data System (ADS)

    Hong, Jianxun; Li, Chengjun; Zhou, Jianxin; Chen, Shuiping; Zhou, Limin; Chen, Wei

    2008-11-01

    A time-domain optical add-drop multiplexing (OADM) technology using microring resonators is reported. Design and simulation are presented. The microring resonator is predicted to be fabricated by using Pockler electro-optic materials. The microring resonators possess a multistage-cascaded structure to satisfy the requirement to generate switching windows. Cascaded coupled microring resonator can expand the single resonant point into a box-like resonant region and reduce the wings of resonant curve. While multistage resonators are used and a certain shift of the resonant region is arranged between the stages, the total resonant region can be expanded further. We achieve the shift of the resonant region between the two stages by selecting different ring radii. The resulted microring resonators possess a box-like characteristic with shape wings. The OADM includes two microring resonators (MMRs) driven by sine wave voltages, one is used to accomplish the add function the other is used to accomplish the drop function. The only operation differences between the two MMRs are the bias voltage and the phase of the driving signal. The OADM only requires electrical control signal and simple structure instead of high-quality optical control pulse and interferometer structure. FDTD simulation results show that the resonators can stratify the requirements to generate complementary switching windows for OADM operation.

  1. 24 CFR 983.206 - HAP contract amendments (to add or substitute contract units).

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 4 2011-04-01 2011-04-01 false HAP contract amendments (to add or... Contract § 983.206 HAP contract amendments (to add or substitute contract units). (a) Amendment to... substitute unit and must determine the reasonable rent for such unit. (b) Amendment to add contract units....

  2. 24 CFR 983.206 - HAP contract amendments (to add or substitute contract units).

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false HAP contract amendments (to add or... Contract § 983.206 HAP contract amendments (to add or substitute contract units). (a) Amendment to... substitute unit and must determine the reasonable rent for such unit. (b) Amendment to add contract units....

  3. 12 CFR 502.60 - When will OTS adjust, add, waive, or eliminate a fee?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false When will OTS adjust, add, waive, or eliminate... TREASURY ASSESSMENTS AND FEES Fees § 502.60 When will OTS adjust, add, waive, or eliminate a fee? Under unusual circumstances, the Director may deem it necessary or appropriate to adjust, add, waive,...

  4. 12 CFR 502.60 - When will OTS adjust, add, waive, or eliminate a fee?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 5 2011-01-01 2011-01-01 false When will OTS adjust, add, waive, or eliminate... TREASURY ASSESSMENTS AND FEES Fees § 502.60 When will OTS adjust, add, waive, or eliminate a fee? Under unusual circumstances, the Director may deem it necessary or appropriate to adjust, add, waive,...

  5. The Source for ADD/ADHD: Attention Deficit Disorder and Attention Deficit/Hyperactivity Disorder.

    ERIC Educational Resources Information Center

    Richard, Gail J.; Russell, Joy L.

    This book is intended for professionals who are responsible for designing and implementing educational programs for children with attention deficit disorders and attention deficit/hyperactivity disorder (ADD/ADHD). Chapters address: (1) myths and realities about ADD/ADHD; (2) definitions, disorders associated with ADD/ADHD, and federal educational…

  6. Marriage and Health in the Transition to Adulthood: Evidence for African Americans in Add Health.

    PubMed

    Harris, Kathleen Mullan; Lee, Hedwig; Deleone, Felicia Yang

    2010-08-01

    This paper examines the relationship between early marriage (before age 26), cohabitation, and health for African Americans and whites during the transition to adulthood using the National Longitudinal Study of Adolescent Health (Add Health). We examine three categories of health outcomes relevant to young adulthood: physical health, mental health, and health risk behaviors. Lagged dependent variable models are used to examine the health effects of early marriage and cohabitation accounting for potential health selection into unions. Our results indicate that early marriage by young adults does not have protective effects for African Americans, and finds more negative effects for African American men than women. There are mixed results for whites with some protective effects of marriage for binge drinking. Early marriage for both African Americans and whites is associated with increased Body Mass Index (BMI). Cohabitation is uniformly associated with negative health outcomes for all race and sex groups.

  7. Effect of “add-on” interventions on exercise training in individuals with COPD: a systematic review

    PubMed Central

    Camillo, Carlos A.; van Remoortel, Hans; Burtin, Chris; Janssens, Wim

    2016-01-01

    The aim of this review was to identify the effectiveness of therapies added on to conventional exercise training to maximise exercise capacity in patients with chronic obstructive pulmonary disease (COPD). Electronic databases were searched, identifying trials comparing exercise training with exercise training plus “add-on” therapy. Outcomes included peak oxygen uptake (V′O2peak), work rate and incremental/endurance cycle and field walking tests. Individual trial effects on exercise capacity were extracted and collated into eight subgroups and pooled for meta-analysis. Sensitivity analyses were conducted to explore the stability of effect estimates across studies employing patient-centred designs and those deemed to be of “high” quality (PEDro score >5 out of 10). 74 studies (2506 subjects) met review inclusion criteria. Interventions spanned a broad scope of clinical practice and were most commonly evaluated via the 6-min walking distance and V′O2peak. Meta-analysis revealed few clinically relevant and statistically significant benefits of “add-on” therapies on exercise performance compared with exercise training. Benefits favouring “add-on” therapies were observed across six different interventions (additional exercise training, noninvasive ventilation, bronchodilator therapy, growth hormone, vitamin D and nutritional supplementation). The sensitivity analyses included considerably fewer studies, but revealed minimal differences to the primary analysis. The lack of systematic benefits of “add-on” interventions is a probable reflection of methodological limitations, such as “one size fits all” eligibility criteria, that are inherent in many of the included studies of “add-on” therapies. Future clarification regarding the exact value of such therapies may only arise from adequately powered, multicentre clinical trials of tailored interventions for carefully selected COPD patient subgroups defined according to distinct clinical

  8. Cirrus Parcel Model Comparison Project. Phase 1; The Critical Components to Simulate Cirrus Initiation Explicitly

    NASA Technical Reports Server (NTRS)

    Lin, Ruei-Fong; Starr, David OC; DeMott, Paul J.; Cotton, Richard; Sassen, Kenneth; Jensen, Eric; Einaudi, Franco (Technical Monitor)

    2001-01-01

    The Cirrus Parcel Model Comparison Project, a project of the GCSS (GEWEX Cloud System Studies) Working Group on Cirrus Cloud Systems, involves the systematic comparison of current models of ice crystal nucleation and growth for specified, typical, cirrus cloud environments. In Phase I of the project reported here, simulated cirrus cloud microphysical properties are compared for situations of "warm" (40 C) and "cold" (-60 C) cirrus, both subject to updrafts of 4, 20 and 100 centimeters per second. Five models participated. The various models employ explicit microphysical schemes wherein the size distribution of each class of particles (aerosols and ice crystals) is resolved into bins or treated separately. Simulations are made including both the homogeneous and heterogeneous ice nucleation mechanisms. A single initial aerosol population of sulfuric acid particles is prescribed for all simulations. To isolate the treatment of the homogeneous freezing (of haze droplets) nucleation process, the heterogeneous nucleation mechanism is disabled for a second parallel set of simulations. Qualitative agreement is found for the homogeneous-nucleation- only simulations, e.g., the number density of nucleated ice crystals increases with the strength of the prescribed updraft. However, significant quantitative differences are found. Detailed analysis reveals that the homogeneous nucleation rate, haze particle solution concentration, and water vapor uptake rate by ice crystal growth (particularly as controlled by the deposition coefficient) are critical components that lead to differences in predicted microphysics. Systematic bias exists between results based on a modified classical theory approach and models using an effective freezing temperature approach to the treatment of nucleation. Each approach is constrained by critical freezing data from laboratory studies, but each includes assumptions that can only be justified by further laboratory research. Consequently, it is not yet

  9. Catchment-scale hydrologic implications of parcel-level stormwater management (Ohio USA)

    NASA Astrophysics Data System (ADS)

    Shuster, William; Rhea, Lee

    2013-04-01

    SummaryThe effectiveness of stormwater management strategies is a key issue affecting decision making on urban water resources management, and so proper monitoring and analysis of pilot studies must be addressed before drawing conclusions. We performed a pilot study in the suburban Shepherd Creek watershed located in Cincinnati, Ohio to evaluate the practicality of voluntary incentives for stormwater quantity reduction on privately owned suburban properties. Stream discharge and precipitation were monitored 3 years before and after implementation of the stormwater management treatments. To implement stormwater control measures, we elicited the participation of citizen landowners with two successive reverse-auctions. Auctions were held in spring 2007, and 2008, resulting in the installation of 85 rain gardens and 174 rain barrels. We demonstrated an analytic process of increasing model flexibility to determine hydrologic effectiveness of stormwater management at the sub-catchment level. A significant albeit small proportion of total variance was explained by both the effects of study period (˜69%) and treatment-vs.-control (˜7%). Precipitation-discharge relationships were synthesized in estimated unit hydrographs, which were decomposed and components tested for influence of treatments. Analysis of unit hydrograph parameters showed a weakened correlation between precipitation and discharge, and support the output from the initial model that parcel-level green infrastructure added detention capacity to treatment basins. We conclude that retrofit management of stormwater runoff quantity with green infrastructure in a small suburban catchment can be successfully initiated with novel economic incentive programs, and that these measures can impart a small, but statistically significant decrease in otherwise uncontrolled runoff volume. Given consistent monitoring data and analysis, water resource managers can use our approach as a way to estimate actual effectiveness of

  10. Deducing logical relationships between spatially registered cortical parcellations under conditions of uncertainty.

    PubMed

    Bezgin, Gleb; Wanke, Egon; Krumnack, Antje; Kötter, Rolf

    2008-10-01

    We propose a new technique, called Spatial Objective Relational Transformation (SORT), as an automated approach for derivation of logical relationships between cortical areas in different brain maps registered in the same Euclidean space. Recently, there have been large amounts of voxel-based three-dimensional structural and functional imaging data that provide us with coordinate-based information about the location of differently defined areas in the brain, whereas coordinate-independent, parcellation-based mapping is still commonly used in the majority of animal tracing and mapping studies. Because of the impact of voxel-based imaging methods and the need to attribute their features to coordinate-independent brain entities, this mapping becomes increasingly important. Our motivation here is not to make vague statements where more precise spatial statements would be better, but to find criteria for the identity (or other logical relationships) between areas that were delineated by different methods, in different individuals, or mapped to three-dimensional space using different deformation algorithms. The relevance of this problem becomes immediately obvious as one superimposes and compares different datasets in multimodal databases (e.g. CARET, http://brainmap.wustl.edu/caret), where voxel-based data are registered to surface nodes exploited by the procedure presented here. We describe the SORT algorithm and its implementation in the Java 2 programming language (http://java.sun.com/, which we make available for download. We give an example of practical use of our approach, and validate the SORT approach against a database of the coordinate-independent statements and inferences that have been deduced using alternative techniques.

  11. Does aquaculture add resilience to the global food system?

    PubMed

    Troell, Max; Naylor, Rosamond L; Metian, Marc; Beveridge, Malcolm; Tyedmers, Peter H; Folke, Carl; Arrow, Kenneth J; Barrett, Scott; Crépin, Anne-Sophie; Ehrlich, Paul R; Gren, Asa; Kautsky, Nils; Levin, Simon A; Nyborg, Karine; Österblom, Henrik; Polasky, Stephen; Scheffer, Marten; Walker, Brian H; Xepapadeas, Tasos; de Zeeuw, Aart

    2014-09-16

    Aquaculture is the fastest growing food sector and continues to expand alongside terrestrial crop and livestock production. Using portfolio theory as a conceptual framework, we explore how current interconnections between the aquaculture, crop, livestock, and fisheries sectors act as an impediment to, or an opportunity for, enhanced resilience in the global food system given increased resource scarcity and climate change. Aquaculture can potentially enhance resilience through improved resource use efficiencies and increased diversification of farmed species, locales of production, and feeding strategies. However, aquaculture's reliance on terrestrial crops and wild fish for feeds, its dependence on freshwater and land for culture sites, and its broad array of environmental impacts diminishes its ability to add resilience. Feeds for livestock and farmed fish that are fed rely largely on the same crops, although the fraction destined for aquaculture is presently small (∼4%). As demand for high-value fed aquaculture products grows, competition for these crops will also rise, as will the demand for wild fish as feed inputs. Many of these crops and forage fish are also consumed directly by humans and provide essential nutrition for low-income households. Their rising use in aquafeeds has the potential to increase price levels and volatility, worsening food insecurity among the most vulnerable populations. Although the diversification of global food production systems that includes aquaculture offers promise for enhanced resilience, such promise will not be realized if government policies fail to provide adequate incentives for resource efficiency, equity, and environmental protection. PMID:25136111

  12. Does aquaculture add resilience to the global food system?

    PubMed Central

    Troell, Max; Naylor, Rosamond L.; Metian, Marc; Beveridge, Malcolm; Tyedmers, Peter H.; Folke, Carl; Arrow, Kenneth J.; Barrett, Scott; Crépin, Anne-Sophie; Ehrlich, Paul R.; Gren, Åsa; Kautsky, Nils; Levin, Simon A.; Nyborg, Karine; Österblom, Henrik; Polasky, Stephen; Scheffer, Marten; Walker, Brian H.; Xepapadeas, Tasos; de Zeeuw, Aart

    2014-01-01

    Aquaculture is the fastest growing food sector and continues to expand alongside terrestrial crop and livestock production. Using portfolio theory as a conceptual framework, we explore how current interconnections between the aquaculture, crop, livestock, and fisheries sectors act as an impediment to, or an opportunity for, enhanced resilience in the global food system given increased resource scarcity and climate change. Aquaculture can potentially enhance resilience through improved resource use efficiencies and increased diversification of farmed species, locales of production, and feeding strategies. However, aquaculture’s reliance on terrestrial crops and wild fish for feeds, its dependence on freshwater and land for culture sites, and its broad array of environmental impacts diminishes its ability to add resilience. Feeds for livestock and farmed fish that are fed rely largely on the same crops, although the fraction destined for aquaculture is presently small (∼4%). As demand for high-value fed aquaculture products grows, competition for these crops will also rise, as will the demand for wild fish as feed inputs. Many of these crops and forage fish are also consumed directly by humans and provide essential nutrition for low-income households. Their rising use in aquafeeds has the potential to increase price levels and volatility, worsening food insecurity among the most vulnerable populations. Although the diversification of global food production systems that includes aquaculture offers promise for enhanced resilience, such promise will not be realized if government policies fail to provide adequate incentives for resource efficiency, equity, and environmental protection. PMID:25136111

  13. The IRBIT domain adds new functions to the AHCY family.

    PubMed

    Devogelaere, Benoit; Sammels, Eva; De Smedt, Humbert

    2008-07-01

    During the past few years, the IRBIT domain has emerged as an important add-on of S-adenosyl-L-homocystein hydrolase (AHCY), thereby creating the new family of AHCY-like proteins. In this review, we discuss the currently available data on this new family of proteins. We describe the IRBIT domain as a unique part of these proteins and give an overview of its regulation via (de)phosphorylation and proteolysis. The second part of this review is focused on the potential functions of the AHCY-like proteins. We propose that the IRBIT domain serves as an anchor for targeting AHCY-like proteins towards cytoplasmic targets. This leads to regulation of (i) intracellular Ca2+ via the inositol 1,4,5-trisphosphate receptor (IP3R), (ii) intracellular pH via the Na+/HCO3 - cotransporters (NBCs); whereas inactivation of the IRBIT domain induces (iii) nuclear translocation and regulation of AHCY activity. Dysfunction of AHCY-like proteins will disturb these three important functions, with various biological implications. PMID:18536033

  14. The IRBIT domain adds new functions to the AHCY family.

    PubMed

    Devogelaere, Benoit; Sammels, Eva; De Smedt, Humbert

    2008-07-01

    During the past few years, the IRBIT domain has emerged as an important add-on of S-adenosyl-L-homocystein hydrolase (AHCY), thereby creating the new family of AHCY-like proteins. In this review, we discuss the currently available data on this new family of proteins. We describe the IRBIT domain as a unique part of these proteins and give an overview of its regulation via (de)phosphorylation and proteolysis. The second part of this review is focused on the potential functions of the AHCY-like proteins. We propose that the IRBIT domain serves as an anchor for targeting AHCY-like proteins towards cytoplasmic targets. This leads to regulation of (i) intracellular Ca2+ via the inositol 1,4,5-trisphosphate receptor (IP3R), (ii) intracellular pH via the Na+/HCO3 - cotransporters (NBCs); whereas inactivation of the IRBIT domain induces (iii) nuclear translocation and regulation of AHCY activity. Dysfunction of AHCY-like proteins will disturb these three important functions, with various biological implications.

  15. Does aquaculture add resilience to the global food system?

    PubMed

    Troell, Max; Naylor, Rosamond L; Metian, Marc; Beveridge, Malcolm; Tyedmers, Peter H; Folke, Carl; Arrow, Kenneth J; Barrett, Scott; Crépin, Anne-Sophie; Ehrlich, Paul R; Gren, Asa; Kautsky, Nils; Levin, Simon A; Nyborg, Karine; Österblom, Henrik; Polasky, Stephen; Scheffer, Marten; Walker, Brian H; Xepapadeas, Tasos; de Zeeuw, Aart

    2014-09-16

    Aquaculture is the fastest growing food sector and continues to expand alongside terrestrial crop and livestock production. Using portfolio theory as a conceptual framework, we explore how current interconnections between the aquaculture, crop, livestock, and fisheries sectors act as an impediment to, or an opportunity for, enhanced resilience in the global food system given increased resource scarcity and climate change. Aquaculture can potentially enhance resilience through improved resource use efficiencies and increased diversification of farmed species, locales of production, and feeding strategies. However, aquaculture's reliance on terrestrial crops and wild fish for feeds, its dependence on freshwater and land for culture sites, and its broad array of environmental impacts diminishes its ability to add resilience. Feeds for livestock and farmed fish that are fed rely largely on the same crops, although the fraction destined for aquaculture is presently small (∼4%). As demand for high-value fed aquaculture products grows, competition for these crops will also rise, as will the demand for wild fish as feed inputs. Many of these crops and forage fish are also consumed directly by humans and provide essential nutrition for low-income households. Their rising use in aquafeeds has the potential to increase price levels and volatility, worsening food insecurity among the most vulnerable populations. Although the diversification of global food production systems that includes aquaculture offers promise for enhanced resilience, such promise will not be realized if government policies fail to provide adequate incentives for resource efficiency, equity, and environmental protection.

  16. Phase I Archaeological Survey of Parcel ED-3 and Historic Assessement of the Happy Valley Worker Camp Roane County, Tennessee

    SciTech Connect

    New South Associates

    2009-08-17

    Parcel ED-3 was the location of a portion of 'Happy Valley', a temporary worker housing area occupied from 1943 to 1947 during the construction of the K-25 Oak Ridge Gaseous Diffusion Plant. The project was carried out under subcontract for the Department of Energy. The survey report will be used in the preparation of an Environmental Assessment under the National Environmental Policy Act (NEPA). New South Associates conducted a Phase I Archaeological Survey of Parcel ED-3 at the US Department of Energy's Oak Ridge Reservation in Roane County, Tennessee. The survey was conducted in two parts. The first survey was carried out in 2008 and covered an area measuring approximately 110 acres. The second survey took place in 2009 and focused on 72 acres west of the first survey area. The objective of the surveys was to identify any archaeological remains associated with Happy Valley and any additional sites on the property and to assess these sites for National Register eligibility. New South Associates also conducted a historic assessment to gather information on Happy Valley. This historic assessment was used in conjunction with the archaeological survey to evaluate the significance of the Happy Valley site. Archaeological remains of Happy Valley were located throughout the parcel, but no additional sites were located. The official state site number for Happy Valley is 40RE577. During the two surveys a total of 13 artifact concentrations, 14 isolated finds, and 75 structural features were located. Due to the Happy Valley's stron gassociation with the Manhattan Project, the site is recommended eligible for the National Register of Historic Places under Criterion A.

  17. Embedding objects during 3D printing to add new functionalities.

    PubMed

    Yuen, Po Ki

    2016-07-01

    A novel method for integrating and embedding objects to add new functionalities during 3D printing based on fused deposition modeling (FDM) (also known as fused filament fabrication or molten polymer deposition) is presented. Unlike typical 3D printing, FDM-based 3D printing could allow objects to be integrated and embedded during 3D printing and the FDM-based 3D printed devices do not typically require any post-processing and finishing. Thus, various fluidic devices with integrated glass cover slips or polystyrene films with and without an embedded porous membrane, and optical devices with embedded Corning(®) Fibrance™ Light-Diffusing Fiber were 3D printed to demonstrate the versatility of the FDM-based 3D printing and embedding method. Fluid perfusion flow experiments with a blue colored food dye solution were used to visually confirm fluid flow and/or fluid perfusion through the embedded porous membrane in the 3D printed fluidic devices. Similar to typical 3D printed devices, FDM-based 3D printed devices are translucent at best unless post-polishing is performed and optical transparency is highly desirable in any fluidic devices; integrated glass cover slips or polystyrene films would provide a perfect optical transparent window for observation and visualization. In addition, they also provide a compatible flat smooth surface for biological or biomolecular applications. The 3D printed fluidic devices with an embedded porous membrane are applicable to biological or chemical applications such as continuous perfusion cell culture or biocatalytic synthesis but without the need for any post-device assembly and finishing. The 3D printed devices with embedded Corning(®) Fibrance™ Light-Diffusing Fiber would have applications in display, illumination, or optical applications. Furthermore, the FDM-based 3D printing and embedding method could also be utilized to print casting molds with an integrated glass bottom for polydimethylsiloxane (PDMS) device replication

  18. Embedding objects during 3D printing to add new functionalities.

    PubMed

    Yuen, Po Ki

    2016-07-01

    A novel method for integrating and embedding objects to add new functionalities during 3D printing based on fused deposition modeling (FDM) (also known as fused filament fabrication or molten polymer deposition) is presented. Unlike typical 3D printing, FDM-based 3D printing could allow objects to be integrated and embedded during 3D printing and the FDM-based 3D printed devices do not typically require any post-processing and finishing. Thus, various fluidic devices with integrated glass cover slips or polystyrene films with and without an embedded porous membrane, and optical devices with embedded Corning(®) Fibrance™ Light-Diffusing Fiber were 3D printed to demonstrate the versatility of the FDM-based 3D printing and embedding method. Fluid perfusion flow experiments with a blue colored food dye solution were used to visually confirm fluid flow and/or fluid perfusion through the embedded porous membrane in the 3D printed fluidic devices. Similar to typical 3D printed devices, FDM-based 3D printed devices are translucent at best unless post-polishing is performed and optical transparency is highly desirable in any fluidic devices; integrated glass cover slips or polystyrene films would provide a perfect optical transparent window for observation and visualization. In addition, they also provide a compatible flat smooth surface for biological or biomolecular applications. The 3D printed fluidic devices with an embedded porous membrane are applicable to biological or chemical applications such as continuous perfusion cell culture or biocatalytic synthesis but without the need for any post-device assembly and finishing. The 3D printed devices with embedded Corning(®) Fibrance™ Light-Diffusing Fiber would have applications in display, illumination, or optical applications. Furthermore, the FDM-based 3D printing and embedding method could also be utilized to print casting molds with an integrated glass bottom for polydimethylsiloxane (PDMS) device replication

  19. 78 FR 55124 - Domestic Mail Contract

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-09

    ... noticing a recent Postal Service filing seeking to add Parcel Select Contract 7 to the competitive product... administrative steps. DATES: Comments are due: September 10, 2013. ADDRESSES: Submit comments electronically via... Select Contract 7 to the competitive product list.\\1\\ The Postal Service asserts that Parcel...

  20. Acoustic add-drop filters based on phononic crystal ring resonators

    NASA Astrophysics Data System (ADS)

    Rostami-Dogolsara, Babak; Moravvej-Farshi, Mohammad Kazem; Nazari, Fakhroddin

    2016-01-01

    We report the design procedure for an acoustic add-drop filter (ADF) composed of two line-defect waveguides coupled through a ring resonator cavity (RRC) all based on a phononic crystal (PnC) platform. Using finite difference time domain and plane wave expansion methods, we study the propagation of acoustic waves through the PnC based ADF structures. Numerical results show that the quality factor for the ADF with a quasisquare ring resonator with a frequency band of 95 Hz centered about 75.21 kHz is Q ˜ 800. We show that the addition of an appropriate scatterer at each RRC corner can reduce the scattering loss, enhancing the quality factor and the transmission efficiency. Moreover, it is also shown that by increasing the coupling gaps between the RRC and waveguides the quality factor can be increased by ˜25 times, at the expense of a significant reduction in the transmission efficiency this is attributed to the enhanced selectivity in expense of weakened coupling. Finally, by varying the effective path length of the acoustic wave in the RRC, via selectively varying the inclusions physical and geometrical properties, we show how one can ultra-fine and fine-tune the resonant frequency of the ADF.

  1. Framland parcels extraction from high-resolution remote sensing images based on the two-stage image classification

    NASA Astrophysics Data System (ADS)

    Liu, Guoying; Song, Xu; Lv, Jing

    2015-12-01

    It is difficult and boring for people to artificially extract farmland parcels from high resolution remote sensing images. Therefore, automatic methods are in the urgent need to release image interpreters from such a work as well as achieve accurate results. In the past years, although many researchers have made attempts to solve this problem by using different techniques and also produced some good results, they still cannot meet the demand of practical applications. In this paper, a farmland extraction method is proposed based on a new technique of two-stage image classification. The first stage aims at producing a map of farmland area by using the supervised iterative conditional mode (ICM), where a novel mixture posterior is proposed based on the tree-structured interpretation of certain complex landscapes, e.g., farmland and building area, and the Markov random field model (MRF) is also used to make use of spatial information between neighboring pixels. The second stage extracts the farmland parcels by using the Meanshift algorithm (MS) based on the hybrid of the original image and the texture image produced by the local binary pattern (LBP) method. We applied our method to a piece of aerial image in the urban area of Taizhou, China. The results show that the proposed method has an ability to produce more accurate results than the MS method.

  2. Decoding the Role of the Insula in Human Cognition: Functional Parcellation and Large-Scale Reverse Inference

    PubMed Central

    Yarkoni, Tal; Khaw, Mel Win; Sanfey, Alan G.

    2013-01-01

    Recent work has indicated that the insula may be involved in goal-directed cognition, switching between networks, and the conscious awareness of affect and somatosensation. However, these findings have been limited by the insula’s remarkably high base rate of activation and considerable functional heterogeneity. The present study used a relatively unbiased data-driven approach combining resting-state connectivity-based parcellation of the insula with large-scale meta-analysis to understand how the insula is anatomically organized based on functional connectivity patterns as well as the consistency and specificity of the associated cognitive functions. Our findings support a tripartite subdivision of the insula and reveal that the patterns of functional connectivity in the resting-state analysis appear to be relatively conserved across tasks in the meta-analytic coactivation analysis. The function of the networks was meta-analytically “decoded” using the Neurosynth framework and revealed that while the dorsoanterior insula is more consistently involved in human cognition than ventroanterior and posterior networks, each parcellated network is specifically associated with a distinct function. Collectively, this work suggests that the insula is instrumental in integrating disparate functional systems involved in processing affect, sensory-motor processing, and general cognition and is well suited to provide an interface between feelings, cognition, and action. PMID:22437053

  3. Small-molecule inhibitors of bacterial AddAB and RecBCD helicase-nuclease DNA repair enzymes.

    PubMed

    Amundsen, Susan K; Spicer, Timothy; Karabulut, Ahmet C; Londoño, Luz Marina; Eberhart, Christina; Fernandez Vega, Virneliz; Bannister, Thomas D; Hodder, Peter; Smith, Gerald R

    2012-05-18

    The AddAB and RecBCD helicase-nucleases are related enzymes prevalent among bacteria but not eukaryotes and are instrumental in the repair of DNA double-strand breaks and in genetic recombination. Although these enzymes have been extensively studied both genetically and biochemically, inhibitors specific for this class of enzymes have not been reported. We developed a high-throughput screen based on the ability of phage T4 gene 2 mutants to grow in Escherichia coli only if the host RecBCD enzyme, or a related helicase-nuclease, is inhibited or genetically inactivated. We optimized this screen for use in 1536-well plates and screened 326,100 small molecules in the NIH molecular libraries sample collection for inhibitors of the Helicobacter pylori AddAB enzyme expressed in an E. coli recBCD deletion strain. Secondary screening used assays with cells expressing AddAB or RecBCD and a viability assay that measured the effect of compounds on cell growth without phage infection. From this screening campaign, 12 compounds exhibiting efficacy and selectivity were tested for inhibition of purified AddAB and RecBCD helicase and nuclease activities and in cell-based assays for recombination; seven were active in the 0.1-50 μM range in one or another assay. Compounds structurally related to two of these were similarly tested, and three were active in the 0.1-50 μM range. These compounds should be useful in further enzymatic, genetic, and physiological studies of these enzymes, both purified and in cells. They may also lead to useful antibacterial agents, since this class of enzymes is needed for successful bacterial infection of mammals.

  4. A human brain atlas derived via n-cut parcellation of resting-state and task-based fMRI data.

    PubMed

    James, George Andrew; Hazaroglu, Onder; Bush, Keith A

    2016-02-01

    The growth of functional MRI has led to development of human brain atlases derived by parcellating resting-state connectivity patterns into functionally independent regions of interest (ROIs). All functional atlases to date have been derived from resting-state fMRI data. But given that functional connectivity between regions varies with task, we hypothesized that an atlas incorporating both resting-state and task-based fMRI data would produce an atlas with finer characterization of task-relevant regions than an atlas derived from resting-state alone. To test this hypothesis, we derived parcellation atlases from twenty-nine healthy adult participants enrolled in the Cognitive Connectome project, an initiative to improve functional MRI's translation into clinical decision-making by mapping normative variance in brain-behavior relationships. Participants underwent resting-state and task-based fMRI spanning nine cognitive domains: motor, visuospatial, attention, language, memory, affective processing, decision-making, working memory, and executive function. Spatially constrained n-cut parcellation derived brain atlases using (1) all participants' functional data (Task) or (2) a single resting-state scan (Rest). An atlas was also derived from random parcellation for comparison purposes (Random). Two methods were compared: (1) a parcellation applied to the group's mean edge weights (mean), and (2) a two-stage approach with parcellation of individual edge weights followed by parcellation of mean binarized edges (two-stage). The resulting Task and Rest atlases had significantly greater similarity with each other (mean Jaccard indices JI=0.72-0.85) than with the Random atlases (JI=0.59-0.63; all p<0.001 after Bonferroni correction). Task and Rest atlas similarity was greatest for the two-stage method (JI=0.85), which has been shown as more robust than the mean method; these atlases also better reproduced voxelwise seed maps of the left dorsolateral prefrontal cortex during

  5. Add-ons in IVF programme – Hype or Hope?

    PubMed Central

    Datta, AK; Campbell, S; Deval, B; Nargund, G

    2015-01-01

    A series of new technologies and adjuvant therapies have been advocated in order to improve the success of IVF treatment. Dehydro-epiandrostenedione, growth hormones, Coenzyme Q 10, calcium ionosphores, immune therapy, heparin, low-dose aspirin, and vasodilators are among commonly prescribed pharmacological adjuvants. New technologies that are proposed to improve IVF outcomes include advanced sperm selection procedures, time- lapse embryo monitoring, preimplantation genetic screening, assisted hatching endometrial injury or embryo-glue. This review looked into current evidence to justify the use of these co-interventions and whether some of them can still be offered while awaiting more robust evidence to con rm or refute their role. PMID:27729969

  6. 7 CFR 360.500 - Petitions to add a taxon to the noxious weed list.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 5 2014-01-01 2014-01-01 false Petitions to add a taxon to the noxious weed list. 360... PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE NOXIOUS WEED REGULATIONS § 360.500 Petitions to add a taxon to the noxious weed list. A person may petition the Administrator to have a...

  7. 7 CFR 360.500 - Petitions to add a taxon to the noxious weed list.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 5 2011-01-01 2011-01-01 false Petitions to add a taxon to the noxious weed list. 360... PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE NOXIOUS WEED REGULATIONS § 360.500 Petitions to add a taxon to the noxious weed list. A person may petition the Administrator to have a...

  8. 7 CFR 360.500 - Petitions to add a taxon to the noxious weed list.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 5 2012-01-01 2012-01-01 false Petitions to add a taxon to the noxious weed list. 360... PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE NOXIOUS WEED REGULATIONS § 360.500 Petitions to add a taxon to the noxious weed list. A person may petition the Administrator to have a...

  9. 7 CFR 360.500 - Petitions to add a taxon to the noxious weed list.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 5 2013-01-01 2013-01-01 false Petitions to add a taxon to the noxious weed list. 360... PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE NOXIOUS WEED REGULATIONS § 360.500 Petitions to add a taxon to the noxious weed list. A person may petition the Administrator to have a...

  10. 75 FR 73075 - Notice of Motion To Add Exhibit to Petition for Declaratory Order and Complaint

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-29

    ... Energy Regulatory Commission Notice of Motion To Add Exhibit to Petition for Declaratory Order and... of Pella, Iowa (Complainant) filed a motion to add a document as Exhibit P-28 to its July 2, 2010... wishing to become a party must file a notice of intervention or motion to intervene, as appropriate....

  11. Prevalence of Aggression and Defiance in Children with ADD/ADHD Tendencies

    ERIC Educational Resources Information Center

    Hill, Janella

    2011-01-01

    Attention Deficit Disorder (ADD) and Attention Deficit Hyperactivity Disorder (ADHD) appear to have become more prevalent in the past few years. Many children who display ADD/ADHD tendencies also display behaviors which cause problems in a classroom setting. Considering the fact that these behaviors could be displayed by the student population as…

  12. Radio Telescopes Will Add to Cassini-Huygens Discoveries

    NASA Astrophysics Data System (ADS)

    2004-12-01

    When the European Space Agency's Huygens spacecraft makes its plunge into the atmosphere of Saturn's moon Titan on January 14, radio telescopes of the National Science Foundation's National Radio Astronomy Observatory (NRAO) will help international teams of scientists extract the maximum possible amount of irreplaceable information from an experiment unique in human history. Huygens is the 700-pound probe that has accompanied the larger Cassini spacecraft on a mission to thoroughly explore Saturn, its rings and its numerous moons. The Green Bank Telescope The Robert C. Byrd Green Bank Telescope CREDIT: NRAO/AUI/NSF (Click on image for GBT gallery) The Robert C. Byrd Green Bank Telescope (GBT) in West Virginia and eight of the ten telescopes of the continent-wide Very Long Baseline Array (VLBA), located at Pie Town and Los Alamos, NM, Fort Davis, TX, North Liberty, IA, Kitt Peak, AZ, Brewster, WA, Owens Valley, CA, and Mauna Kea, HI, will directly receive the faint signal from Huygens during its descent. Along with other radio telescopes in Australia, Japan, and China, the NRAO facilities will add significantly to the information about Titan and its atmosphere that will be gained from the Huygens mission. A European-led team will use the radio telescopes to make extremely precise measurements of the probe's position during its descent, while a U.S.-led team will concentrate on gathering measurements of the probe's descent speed and the direction of its motion. The radio-telescope measurements will provide data vital to gaining a full understanding of the winds that Huygens encounters in Titan's atmosphere. Currently, scientists know little about Titan's winds. Data from the Voyager I spacecraft's 1980 flyby indicated that east-west winds may reach 225 mph or more. North-south winds and possible vertical winds, while probably much weaker, may still be significant. There are competing theoretical models of Titan's winds, and the overall picture is best summarized as

  13. What Do Molecular Tests Add to Prognostic Stratification in MF: Is It Time to Add These to Our Clinical Practice?

    PubMed

    Guglielmelli, Paola; Rotunno, Giada; Pacilli, Annalisa; Vannucchi, Alessandro Maria

    2015-12-01

    The molecular landscape of patients with myelofibrosis (MF) includes "phenotypic driver" and "subclonal" mutations. The three driver (JAK2, MPL and CALR)-mutated genes currently represent major diagnostic criteria, unlike subclonal mutations that are not specific for the disease and occur in other myeloid neoplasms. Recent data indicate that selected mutations deserve prognostic significance allowing to identify categories of patients with different survival and risk of leukemia. This review focuses on current knowledge regarding genotype-prognostic correlates in MF, however, with the understanding that this is a rapid moving field and no definite recommendations for the clinicians can be done yet.

  14. A PC add-on card for Mössbauer data acquisition system

    NASA Astrophysics Data System (ADS)

    Chittaranjan, C. M.; Jayapandian, J.; Gopinathan, K. P.

    1993-02-01

    A user friendly Mössbauer data acquisition add-on card for IBM compatible PC has been designed and fabricated. It is a firmware which acquires data and shares the CPU of the host PC to transfer the data into the PC memory. The card generates the wave form for the drive unit, generates dwell time marker pulses and counts the energy selected single channel analyzer (SCA) pulses. The significant feature of the system is that the counting of the SCA pulses is done with two counters, resulting in zero dead time. Two temporary dual port RAMs (DP RAM) on board enable real time data acquisition. The software which controls the hardware is menu driven and user friendly and works under DOS environment. An on line display of the spectrum is provided with a cursor which enables the inspection of counts in any channel during the acquisition. The current version of the spectrometer has a capacity of 2048 channels and this can be extended easily up to 8192 channels.

  15. Characterization of the temporo-parietal junction by combining data-driven parcellation, complementary connectivity analyses, and functional decoding

    PubMed Central

    Bzdok, Danilo; Langner, Robert; Schilbach, Leonhard; Jakobs, Oliver; Roski, Christian; Caspers, Svenja; Laird, Angela R.; Fox, Peter T.; Zilles, Karl; Eickhoff, Simon B.

    2016-01-01

    The right temporo-parietal junction (RTPJ) is consistently implicated in two cognitive domains, attention and social cognitions. We conducted multi-modal connectivity-based parcellation to investigate potentially separate functional modules within RTPJ implementing this cognitive dualism. Both task-constrained meta-analytic coactivation mapping and task-free resting-state connectivity analysis independently identified two distinct clusters within RTPJ, subsequently characterized by network mapping and functional forward/reverse inference. Coactivation mapping and resting-state correlations revealed that the anterior cluster increased neural activity concomitantly with a midcingulate–motor–insular network, functionally associated with attention, and decreased neural activity concomitantly with a parietal network, functionally associated with social cognition and memory retrieval. The posterior cluster showed the exact opposite association pattern. Our data thus suggest that RTPJ links two antagonistic brain networks processing external versus internal information. PMID:23689016

  16. Familiarity adds to attractiveness in matters of siskin mate choice.

    PubMed

    Senar, J C; Mateos-Gonzalez, F; Uribe, F; Arroyo, L

    2013-12-22

    There is currently considerable controversy in evolutionary ecology revolving around whether social familiarity brings attraction when a female chooses a mate. The topic of familiarity is significant because by avoiding or preferring familiar individuals as mates, the potential for local adaptation may be reduced or favoured. The topic becomes even more interesting if we simultaneously analyse preferences for familiarity and sexual ornaments, because when familiarity influences female mating preferences, this could very significantly affect the strength of sexual selection on male ornamentation. Here, we have used mate-choice experiments in siskins Carduelis spinus to analyse how familiarity and patterns of ornamentation (i.e. the size of wing patches) interact to influence mating success. Our results show that females clearly prefer familiar individuals when choosing between familiar and unfamiliar males with similar-sized wing patches. Furthermore, when females were given the choice between a highly ornamented unfamiliar male and a less ornamented familiar male, half of the females still preferred the socially familiar birds as mates. Our finding suggests that male familiarity may be as important as sexual ornaments in affecting female behaviour in mate choice. Given that the potential for local adaptation may be favoured by preferring familiar individuals as mates, social familiarity as a mate-choice criterion may become a potential area of fruitful research on sympatric speciation processes.

  17. Familiarity adds to attractiveness in matters of siskin mate choice

    PubMed Central

    Senar, J. C.; Mateos-Gonzalez, F.; Uribe, F.; Arroyo, L.

    2013-01-01

    There is currently considerable controversy in evolutionary ecology revolving around whether social familiarity brings attraction when a female chooses a mate. The topic of familiarity is significant because by avoiding or preferring familiar individuals as mates, the potential for local adaptation may be reduced or favoured. The topic becomes even more interesting if we simultaneously analyse preferences for familiarity and sexual ornaments, because when familiarity influences female mating preferences, this could very significantly affect the strength of sexual selection on male ornamentation. Here, we have used mate-choice experiments in siskins Carduelis spinus to analyse how familiarity and patterns of ornamentation (i.e. the size of wing patches) interact to influence mating success. Our results show that females clearly prefer familiar individuals when choosing between familiar and unfamiliar males with similar-sized wing patches. Furthermore, when females were given the choice between a highly ornamented unfamiliar male and a less ornamented familiar male, half of the females still preferred the socially familiar birds as mates. Our finding suggests that male familiarity may be as important as sexual ornaments in affecting female behaviour in mate choice. Given that the potential for local adaptation may be favoured by preferring familiar individuals as mates, social familiarity as a mate-choice criterion may become a potential area of fruitful research on sympatric speciation processes. PMID:24174112

  18. Familiarity adds to attractiveness in matters of siskin mate choice.

    PubMed

    Senar, J C; Mateos-Gonzalez, F; Uribe, F; Arroyo, L

    2013-12-22

    There is currently considerable controversy in evolutionary ecology revolving around whether social familiarity brings attraction when a female chooses a mate. The topic of familiarity is significant because by avoiding or preferring familiar individuals as mates, the potential for local adaptation may be reduced or favoured. The topic becomes even more interesting if we simultaneously analyse preferences for familiarity and sexual ornaments, because when familiarity influences female mating preferences, this could very significantly affect the strength of sexual selection on male ornamentation. Here, we have used mate-choice experiments in siskins Carduelis spinus to analyse how familiarity and patterns of ornamentation (i.e. the size of wing patches) interact to influence mating success. Our results show that females clearly prefer familiar individuals when choosing between familiar and unfamiliar males with similar-sized wing patches. Furthermore, when females were given the choice between a highly ornamented unfamiliar male and a less ornamented familiar male, half of the females still preferred the socially familiar birds as mates. Our finding suggests that male familiarity may be as important as sexual ornaments in affecting female behaviour in mate choice. Given that the potential for local adaptation may be favoured by preferring familiar individuals as mates, social familiarity as a mate-choice criterion may become a potential area of fruitful research on sympatric speciation processes. PMID:24174112

  19. Health information: what can mobile phone assessments add?

    PubMed

    Stomberg, Margareta Warrén; Platon, Birgitta; Widén, Annette; Wallner, Ingegerd; Karlsson, Ove

    2012-01-01

    In healthcare, pain assessment is a key factor in effectively treating postoperative pain and reducing the risk of developing chronic pain. The overall aim of this study was to investigate whether a mobile phone support system can be used as a basis to continuously document patients' health information in real time and provide conditions for optimal, individual pain management after cholecystectomy and hysterectomy procedures.In this pilot study, two randomly selected groups of patients provided information about their pain for one week postoperatively. One group responded via cell phones, and the other, a control group, responded using paper-based questionnaires.The mobile phone system was found to provide a fast and safe basis for reporting pain postoperatively in real time. The results indicate that on days 3 and 4 the mobile phone group reported significantly higher levels of pain than the control group, and the cholecystectomy patients reported significantly more pain at movement on days 3 and 4 than the hysterectomy patients.The mobile phone approach is an adaptation to modern technology and the mobility of individuals. This technology is user friendly and requires minimal support. However, as the sample size was small (n = 37), further studies are needed before additional conclusions can be drawn.

  20. Health information: what can mobile phone assessments add?

    PubMed

    Stomberg, Margareta Warrén; Platon, Birgitta; Widén, Annette; Wallner, Ingegerd; Karlsson, Ove

    2012-01-01

    In healthcare, pain assessment is a key factor in effectively treating postoperative pain and reducing the risk of developing chronic pain. The overall aim of this study was to investigate whether a mobile phone support system can be used as a basis to continuously document patients' health information in real time and provide conditions for optimal, individual pain management after cholecystectomy and hysterectomy procedures.In this pilot study, two randomly selected groups of patients provided information about their pain for one week postoperatively. One group responded via cell phones, and the other, a control group, responded using paper-based questionnaires.The mobile phone system was found to provide a fast and safe basis for reporting pain postoperatively in real time. The results indicate that on days 3 and 4 the mobile phone group reported significantly higher levels of pain than the control group, and the cholecystectomy patients reported significantly more pain at movement on days 3 and 4 than the hysterectomy patients.The mobile phone approach is an adaptation to modern technology and the mobility of individuals. This technology is user friendly and requires minimal support. However, as the sample size was small (n = 37), further studies are needed before additional conclusions can be drawn. PMID:23209453

  1. Environmental Baseline Survey Report for the Title Transfer of Land Parcel ED-4 at the East Tennessee Technology Park, Oak Ridge, Tennessee

    SciTech Connect

    SAIC

    2008-05-01

    This environmental baseline survey (EBS) report documents the baseline environmental conditions of a land parcel referred to as 'ED-4' (ED-4) at the U. S. Department of Energy's (DOE's) East Tennessee Technology Park (ETTP). DOE is proposing to transfer the title of this land to the Heritage Center, LLC. Parcel ED-4 is a land parcel that consists of two noncontiguous areas comprising a total of approximately 18 acres located east of the ETTP. The western tract of ED-4 encompasses approximately 8.5 acres in the northeastern quadrant of the intersection of Boulevard Road and Highway 58. The eastern tract encompasses an area of approximately 9.5 acres in the northwestern quadrant of the intersection of Blair Road and Highway 58 (the Oak Ridge Turnpike). Aerial photographs and site maps from throughout the history of the ETTP, going back to its initial development in the 1940s as the Oak Ridge Gaseous Diffusion Plant (ORGDP), indicate that this area has been undeveloped woodland with the exception of three support facilities for workers constructing the ORGDP since federal acquisition in 1943. These three support facilities, which were located in the western tract of ED-4, included a recreation hall, the Town Hall Camp Operations Building, and the Property Warehouse. A railroad spur also formerly occupied a portion of Parcel ED-4. These former facilities only occupied approximately 5 percent of the total area of Parcel ED-4. This report provides supporting information for the transfer of this government-owned property at ETTP to a non-federal entity. This EBS is based upon the requirements of Sect. 120(h) of the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA). In order to support a Clean Parcel Determination (CPD) in accordance with CERCLA Sect. 120(h)(4)(d), groundwater and sediment samples were collected within, and adjacent to, the Parcel ED-4 study area. The potential for DOE to make a CPD for ED-4 is further supported by a No

  2. Using the PhenX Toolkit to Add Standard Measures to a Study.

    PubMed

    Hendershot, Tabitha; Pan, Huaqin; Haines, Jonathan; Harlan, William R; Marazita, Mary L; McCarty, Catherine A; Ramos, Erin M; Hamilton, Carol M

    2015-07-01

    The PhenX (consensus measures for Phenotypes and eXposures) Toolkit (https://www.phenxtoolkit.org/) offers high-quality, well-established measures of phenotypes and exposures for use by the scientific community. The goal is to promote the use of standard measures, enhance data interoperability, and help investigators identify opportunities for collaborative and translational research. The Toolkit contains 395 measures drawn from 22 research domains (fields of research), along with additional collections of measures for Substance Abuse and Addiction (SAA) research, Mental Health Research (MHR), and Tobacco Regulatory Research (TRR). Additional measures for TRR that are expected to be released in 2015 include Obesity, Eating Disorders, and Sickle Cell Disease. Measures are selected by working groups of domain experts using a consensus process that includes input from the scientific community. The Toolkit provides a description of each PhenX measure, the rationale for including it in the Toolkit, protocol(s) for collecting the measure, and supporting documentation. Users can browse measures in the Toolkit or can search the Toolkit using the Smart Query Tool or a full text search. PhenX Toolkit users select measures of interest to add to their Toolkit. Registered Toolkit users can save their Toolkit and return to it later to revise or complete. They then have options to download a customized Data Collection Worksheet that specifies the data to be collected, and a Data Dictionary that describes each variable included in the Data Collection Worksheet. The Toolkit also has a Register Your Study feature that facilitates cross-study collaboration by allowing users to find other investigators using the same PhenX measures.

  3. 77 FR 59610 - Flonicamid; Applications To Add New Food Uses on Previously Registered Pesticide Products

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-28

    ... applications to add new food uses on previously registered pesticide products containing the insecticide, flonicamide, pursuant to the provisions of section 3(c) of the Federal Insecticide, Fungicide, and Rodenticide... registered pesticide products containing the insecticide, flonicamid,...

  4. Mothers whose children have ADD/ADHD discuss their children's medication use: an investigation of blogs.

    PubMed

    Clarke, Juanne N; Lang, Laura

    2012-01-01

    This article presents the results of a frame and discourse analysis of Internet blog sites where parents (usually mothers) discuss their concerns about medication use by their children with attention deficit disorder or attention deficit hyperactivity disorder (ADD/ADHD). This is a particularly important topic in an era characterized by powerful circulating discourses around the contentious medicalization of, and prevalent pharmaceutical treatments for, ADD/ADHD, as well as the mother blame associated with having a child diagnosed with ADD/ADHD. The findings document that the mothers see ADD/ADHD as legitimate medical diagnoses and view themselves as caretakers of children with brain and neuro-chemical anomalies affecting the behavior of their children. They favor pharmaceutical use and describe themselves as experts in the difficult and complex issues related to pharmaceuticalized parenting. At the same time their adoption of medicalization is contingent as they express specific critiques of some doctors, some types of doctors, and critically evaluate science.

  5. 42 CFR 82.16 - How will NIOSH add to monitoring data to remedy limitations of individual monitoring and missed...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false How will NIOSH add to monitoring data to remedy... PROGRAM ACT OF 2000 Dose Reconstruction Process § 82.16 How will NIOSH add to monitoring data to remedy... to add this to the total dose estimate. For monitoring periods where external dosimetry data...

  6. A novel optical path routing network that combines coarse granularity optical multicast with fine granularity add/drop and block

    NASA Astrophysics Data System (ADS)

    Soares, Mauro M.; Mori, Yojiro; Hasegawa, Hiroshi; Sato, Ken-ichi

    2015-01-01

    We propose a novel optical path routing mechanism that combines coarse-granularity optical multicast with fine-granularity add/drop and block. We implement the proposal in an optical cross-connect node with broadcast-and-select functionality that offers high cost-effectiveness since no addition equipment from conventional ROADMs is needed. The proposed method, called branching, enhances the routing capabilities over the original grouped routing networks by enabling wavelength paths to be established through different GRE pipes. We also present a novel path/GRE routing and wavelength/GRE index assignment algorithm that supports the new routing function. Numerical experiments using real network topologies verify the improved routing performance and the superior efficiency of the proposed control algorithm over original GRE-based networks.

  7. Mitigation Action Plan: Lease of Parcel ED-1 of the Oak Ridge Reservation by the East Tennessee Economic Council

    SciTech Connect

    1996-04-01

    In April 1996, the U.S. Department of Energy (DOE) completed an environmental assessment (EA) (DOE/EA-1113) for the proposed lease of 957-16 acres (Parcel ED-1) of the Oak Ridge (Tennessee) Reservation (ORR) by the East Tennessee Economic Council (ETEC) for industrial development. DOE plans to issue a Finding of No Significant Impact (FONSI) for the proposed action, conditional upon the implementation of mitigation and monitoring to protect environmental resources. According to DOE`s National Environmental Policy Act (NEPA) regulations (10 CFR 1021.322), a FONSI shall include {open_quotes}any commitments to mitigations that are essential to render the impacts of the proposed action not significant, beyond those mitigations that are integral elements of the proposed action, and a reference to the Mitigation Action Plan prepared under 10 CTR 1021.331{close_quotes}. Terms of the lease offer DOE the option of terminating the lease with ETEC should the lessee and/or sublessees fail to implement the mitigation defined in the FONSI.

  8. Parcellation of the Healthy Neonatal Brain into 107 Regions Using Atlas Propagation through Intermediate Time Points in Childhood

    PubMed Central

    Blesa, Manuel; Serag, Ahmed; Wilkinson, Alastair G.; Anblagan, Devasuda; Telford, Emma J.; Pataky, Rozalia; Sparrow, Sarah A.; Macnaught, Gillian; Semple, Scott I.; Bastin, Mark E.; Boardman, James P.

    2016-01-01

    Neuroimage analysis pipelines rely on parcellated atlases generated from healthy individuals to provide anatomic context to structural and diffusion MRI data. Atlases constructed using adult data introduce bias into studies of early brain development. We aimed to create a neonatal brain atlas of healthy subjects that can be applied to multi-modal MRI data. Structural and diffusion 3T MRI scans were acquired soon after birth from 33 typically developing neonates born at term (mean postmenstrual age at birth 39+5 weeks, range 37+2–41+6). An adult brain atlas (SRI24/TZO) was propagated to the neonatal data using temporal registration via childhood templates with dense temporal samples (NIH Pediatric Database), with the final atlas (Edinburgh Neonatal Atlas, ENA33) constructed using the Symmetric Group Normalization (SyGN) method. After this step, the computed final transformations were applied to T2-weighted data, and fractional anisotropy, mean diffusivity, and tissue segmentations to provide a multi-modal atlas with 107 anatomical regions; a symmetric version was also created to facilitate studies of laterality. Volumes of each region of interest were measured to provide reference data from normal subjects. Because this atlas is generated from step-wise propagation of adult labels through intermediate time points in childhood, it may serve as a useful starting point for modeling brain growth during development. PMID:27242423

  9. Integrated Testing, Simulation and Analysis of Electric Drive Options for Medium-Duty Parcel Delivery Vehicles: Preprint

    SciTech Connect

    Ramroth, L. A.; Gonder, J.; Brooker, A.

    2012-09-01

    The National Renewable Energy Laboratory verified diesel-conventional and diesel-hybrid parcel delivery vehicle models to evaluate petroleum reduction and cost implications of plug-in hybrid gasoline and diesel variants. These variants are run on a field-data-derived design matrix to analyze the effects of drive cycle, distance, battery replacements, battery capacity, and motor power on fuel consumption and lifetime cost. Two cost scenarios using fuel prices corresponding to forecasted highs for 2011 and 2030 and battery costs per kilowatt-hour representing current and long-term targets compare plug-in hybrid lifetime costs with diesel conventional lifetime costs. Under a future cost scenario of $100/kWh battery energy and $5/gal fuel, plug-in hybrids are cost effective. Assuming a current cost of $700/kWh and $3/gal fuel, they rarely recoup the additional motor and battery cost. The results highlight the importance of understanding the application's drive cycle, daily driving distance, and kinetic intensity. For instances in the current-cost scenario where the additional plug-in hybrid cost is regained in fuel savings, the combination of kinetic intensity and daily distance travelled does not coincide with the usage patterns observed in the field data. If the usage patterns were adjusted, the hybrids could become cost effective.

  10. Assessing the Battery Cost at Which Plug-In Hybrid Medium-Duty Parcel Delivery Vehicles Become Cost-Effective

    SciTech Connect

    Ramroth, L. A.; Gonder, J. D.; Brooker, A. D.

    2013-04-01

    The National Renewable Energy Laboratory (NREL) validated diesel-conventional and diesel-hybrid medium-duty parcel delivery vehicle models to evaluate petroleum reductions and cost implications of hybrid and plug-in hybrid diesel variants. The hybrid and plug-in hybrid variants are run on a field data-derived design matrix to analyze the effect of drive cycle, distance, engine downsizing, battery replacements, and battery energy on fuel consumption and lifetime cost. For an array of diesel fuel costs, the battery cost per kilowatt-hour at which the hybridized configuration becomes cost-effective is calculated. This builds on a previous analysis that found the fuel savings from medium duty plug-in hybrids more than offset the vehicles' incremental price under future battery and fuel cost projections, but that they seldom did so under present day cost assumptions in the absence of purchase incentives. The results also highlight the importance of understanding the application's drive cycle specific daily distance and kinetic intensity.

  11. NeuroVault.org: A repository for sharing unthresholded statistical maps, parcellations, and atlases of the human brain.

    PubMed

    Gorgolewski, Krzysztof J; Varoquaux, Gael; Rivera, Gabriel; Schwartz, Yannick; Sochat, Vanessa V; Ghosh, Satrajit S; Maumet, Camille; Nichols, Thomas E; Poline, Jean-Baptiste; Yarkoni, Tal; Margulies, Daniel S; Poldrack, Russell A

    2016-01-01

    NeuroVault.org is dedicated to storing outputs of analyses in the form of statistical maps, parcellations and atlases, a unique strategy that contrasts with most neuroimaging repositories that store raw acquisition data or stereotaxic coordinates. Such maps are indispensable for performing meta-analyses, validating novel methodology, and deciding on precise outlines for regions of interest (ROIs). NeuroVault is open to maps derived from both healthy and clinical populations, as well as from various imaging modalities (sMRI, fMRI, EEG, MEG, PET, etc.). The repository uses modern web technologies such as interactive web-based visualization, cognitive decoding, and comparison with other maps to provide researchers with efficient, intuitive tools to improve the understanding of their results. Each dataset and map is assigned a permanent Universal Resource Locator (URL), and all of the data is accessible through a REST Application Programming Interface (API). Additionally, the repository supports the NIDM-Results standard and has the ability to parse outputs from popular FSL and SPM software packages to automatically extract relevant metadata. This ease of use, modern web-integration, and pioneering functionality holds promise to improve the workflow for making inferences about and sharing whole-brain statistical maps.

  12. NeuroVault.org: A repository for sharing unthresholded statistical maps, parcellations, and atlases of the human brain.

    PubMed

    Gorgolewski, Krzysztof J; Varoquaux, Gael; Rivera, Gabriel; Schwartz, Yannick; Sochat, Vanessa V; Ghosh, Satrajit S; Maumet, Camille; Nichols, Thomas E; Poline, Jean-Baptiste; Yarkoni, Tal; Margulies, Daniel S; Poldrack, Russell A

    2016-01-01

    NeuroVault.org is dedicated to storing outputs of analyses in the form of statistical maps, parcellations and atlases, a unique strategy that contrasts with most neuroimaging repositories that store raw acquisition data or stereotaxic coordinates. Such maps are indispensable for performing meta-analyses, validating novel methodology, and deciding on precise outlines for regions of interest (ROIs). NeuroVault is open to maps derived from both healthy and clinical populations, as well as from various imaging modalities (sMRI, fMRI, EEG, MEG, PET, etc.). The repository uses modern web technologies such as interactive web-based visualization, cognitive decoding, and comparison with other maps to provide researchers with efficient, intuitive tools to improve the understanding of their results. Each dataset and map is assigned a permanent Universal Resource Locator (URL), and all of the data is accessible through a REST Application Programming Interface (API). Additionally, the repository supports the NIDM-Results standard and has the ability to parse outputs from popular FSL and SPM software packages to automatically extract relevant metadata. This ease of use, modern web-integration, and pioneering functionality holds promise to improve the workflow for making inferences about and sharing whole-brain statistical maps. PMID:25869863

  13. Parcellation of the Healthy Neonatal Brain into 107 Regions Using Atlas Propagation through Intermediate Time Points in Childhood.

    PubMed

    Blesa, Manuel; Serag, Ahmed; Wilkinson, Alastair G; Anblagan, Devasuda; Telford, Emma J; Pataky, Rozalia; Sparrow, Sarah A; Macnaught, Gillian; Semple, Scott I; Bastin, Mark E; Boardman, James P

    2016-01-01

    Neuroimage analysis pipelines rely on parcellated atlases generated from healthy individuals to provide anatomic context to structural and diffusion MRI data. Atlases constructed using adult data introduce bias into studies of early brain development. We aimed to create a neonatal brain atlas of healthy subjects that can be applied to multi-modal MRI data. Structural and diffusion 3T MRI scans were acquired soon after birth from 33 typically developing neonates born at term (mean postmenstrual age at birth 39(+5) weeks, range 37(+2)-41(+6)). An adult brain atlas (SRI24/TZO) was propagated to the neonatal data using temporal registration via childhood templates with dense temporal samples (NIH Pediatric Database), with the final atlas (Edinburgh Neonatal Atlas, ENA33) constructed using the Symmetric Group Normalization (SyGN) method. After this step, the computed final transformations were applied to T2-weighted data, and fractional anisotropy, mean diffusivity, and tissue segmentations to provide a multi-modal atlas with 107 anatomical regions; a symmetric version was also created to facilitate studies of laterality. Volumes of each region of interest were measured to provide reference data from normal subjects. Because this atlas is generated from step-wise propagation of adult labels through intermediate time points in childhood, it may serve as a useful starting point for modeling brain growth during development.

  14. Four-channel optical add-drop multiplexer based on dual racetrack micro-ring resonators

    NASA Astrophysics Data System (ADS)

    Wu, Danning; Wu, Yuanda; Wang, Yue; An, Junming; Hu, Xiongwei

    2015-11-01

    In this paper we report on a four-channel optical add-drop multiplexer based on dual racetrack micro-ring resonators in submicron SOI rib waveguides. The free spectral range (FSR) is about 18.6 nm. The device can add/drop four optical channels in half C-band. When the device acts as an optical drop multiplexer, the channel spacing is about 1.5 nm, maximum extinction ratio is 23.75 dB, the minimum insertion loss 9.94 dB and the maximum adjacent channels crosstalk is -12.12 dB. When the device acts as an optical add multiplexer, the maximum extinction ratio is 28.72 dB and the minimum insertion loss 7.35 dB. The fabricated device has effectively and perfectly realized the signals upload and download.

  15. Photothermally tunable silicon-microring-based optical add-drop filter through integrated light absorber.

    PubMed

    Chen, Xi; Shi, Yuechun; Lou, Fei; Chen, Yiting; Yan, Min; Wosinski, Lech; Qiu, Min

    2014-10-20

    An optically pumped thermo-optic (TO) silicon ring add-drop filter with fast thermal response is experimentally demonstrated. We propose that metal-insulator-metal (MIM) light absorber can be integrated into silicon TO devices, acting as a localized heat source which can be activated remotely by a pump beam. The MIM absorber design introduces less thermal capacity to the device, compared to conventional electrically-driven approaches. Experimentally, the absorber-integrated add-drop filter shows an optical response time of 13.7 μs following the 10%-90% rule (equivalent to a exponential time constant of 5 μs) and a wavelength shift over pump power of 60 pm/mW. The photothermally tunable add-drop filter may provide new perspectives for all-optical routing and switching in integrated Si photonic circuits. PMID:25401557

  16. Multichannel optical add-drop processes in symmetrical waveguide-resonator systems.

    PubMed

    Jiang, Wei; Chen, Ray T

    2003-11-21

    Multichannel optical add-drop processes are studied in a class of symmetric waveguide-resonator systems. With insight gained from group theory, we analyze these systems and show that they can add or drop multiple wavelengths simultaneously, with 100% efficiency. A new mechanism is presented to reduce the remnant light at the dropped wavelengths in the pass-through port. High-order Butterworth filters can also be achieved in these systems. Built upon conventional or photonic-crystal based structures, these systems can be used in optical communication applications.

  17. Parcellating the neuroanatomical basis of impaired decision-making in traumatic brain injury.

    PubMed

    Newcombe, Virginia F J; Outtrim, Joanne G; Chatfield, Doris A; Manktelow, Anne; Hutchinson, Peter J; Coles, Jonathan P; Williams, Guy B; Sahakian, Barbara J; Menon, David K

    2011-03-01

    dissociate the location and extent of damage with performance on the various task components using diffusion tensor imaging allows important insights into the neuroanatomical basis of impulsivity following traumatic brain injury. The ability to detect such damage in vivo may have important implications for patient management, patient selection for trials, and to help understand complex neurocognitive pathways.

  18. Parcellating the neuroanatomical basis of impaired decision-making in traumatic brain injury

    PubMed Central

    Outtrim, Joanne G.; Chatfield, Doris A.; Manktelow, Anne; Hutchinson, Peter J.; Coles, Jonathan P.; Williams, Guy B.; Sahakian, Barbara J.; Menon, David K.

    2011-01-01

    dissociate the location and extent of damage with performance on the various task components using diffusion tensor imaging allows important insights into the neuroanatomical basis of impulsivity following traumatic brain injury. The ability to detect such damage in vivo may have important implications for patient management, patient selection for trials, and to help understand complex neurocognitive pathways. PMID:21310727

  19. Psychometric Properties and Norms of the German ABC-Community and PAS-ADD Checklist

    ERIC Educational Resources Information Center

    Zeilinger, Elisabeth L.; Weber, Germain; Haveman, Meindert J.

    2011-01-01

    Aim: The aim of the present study was to standardize and generate psychometric evidence of the German language versions of two well-established English language mental health instruments: the "Aberrant Behavior Checklist-Community" (ABC-C) and the "Psychiatric Assessment Schedule for Adults with Developmental Disabilities" (PAS-ADD) Checklist. New…

  20. 47 CFR 73.9006 - Add-in covered demodulator products.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Section 73.9006 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES RADIO BROADCAST SERVICES Digital Broadcast Television Redistribution Control § 73.9006 Add-in covered...) Using a robust method; or (2) Protected by an authorized digital output protection technology...

  1. Break out of the box: how to add value to the security function.

    PubMed

    Jones, Russell F

    2007-01-01

    Opportunities to create programs that enhance the value of the security function are present now and will be in the future, according to the author, who illustrates a number of ways the resourceful security practitioner can add to his department's reputation and his organization's bottom line.

  2. Project DyAdd: Visual Attention in Adult Dyslexia and ADHD

    ERIC Educational Resources Information Center

    Laasonen, Marja; Salomaa, Jonna; Cousineau, Denis; Leppamaki, Sami; Tani, Pekka; Hokkanen, Laura; Dye, Matthew

    2012-01-01

    In this study of the project DyAdd, three aspects of visual attention were investigated in adults (18-55 years) with dyslexia (n = 35) or attention deficit/hyperactivity disorder (ADHD, n = 22), and in healthy controls (n = 35). Temporal characteristics of visual attention were assessed with Attentional Blink (AB), capacity of visual attention…

  3. How to Add Philosophy Dimensions in Your Basic International Business Course

    ERIC Educational Resources Information Center

    Thanopoulos, John

    2010-01-01

    This article aims to assist professors in introducing concepts of self, philosophy, religions, the universe, existential dilemmas, etc., in their basic international business classes. Using active learning and five-member student teams, a student organized and administered conference adds a very useful dimension of knowledge sacrificing only one…

  4. 40 CFR 75.34 - Units with add-on emission controls.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... assurance/quality control program for the unit, required by section 1 in appendix B of this part. To provide... parametric data to verify the proper operation of the SO2 or NOX add-on emission controls during each hour, as described in paragraph (d) of this section. For any missing data hour(s) in which such...

  5. TEST DESIGN FOR ENVIRONMENTAL TECHNOLOGY VERIFICATION (ETV) OF ADD-ON NOX CONTROL UTILIZING OZONE INJECTION

    EPA Science Inventory

    The paper discusses the test design for environmental technology verification (ETV) of add-0n nitrogen oxides (NOx) control utilizing ozone injection. (NOTE: ETV is an EPA-established program to enhance domestic and international market acceptance of new or improved commercially...

  6. Strategies for Successfully Teaching Students with ADD or ADHD in Instrumental Lessons

    ERIC Educational Resources Information Center

    Melago, Kathleen A.

    2014-01-01

    Teachers can easily encounter students with Attention Deficit Disorder (ADD) or Attention Deficit Hyperactivity Disorder (ADHD) in the instrumental lesson setting. Applicable to instrumental lesson settings in the public or private schools, private studios, or college studios, this article focuses on specific strategies ranging from the…

  7. Neural Biomarkers for Dyslexia, ADHD, and ADD in the Auditory Cortex of Children.

    PubMed

    Serrallach, Bettina; Groß, Christine; Bernhofs, Valdis; Engelmann, Dorte; Benner, Jan; Gündert, Nadine; Blatow, Maria; Wengenroth, Martina; Seitz, Angelika; Brunner, Monika; Seither, Stefan; Parncutt, Richard; Schneider, Peter; Seither-Preisler, Annemarie

    2016-01-01

    Dyslexia, attention deficit hyperactivity disorder (ADHD), and attention deficit disorder (ADD) show distinct clinical profiles that may include auditory and language-related impairments. Currently, an objective brain-based diagnosis of these developmental disorders is still unavailable. We investigated the neuro-auditory systems of dyslexic, ADHD, ADD, and age-matched control children (N = 147) using neuroimaging, magnetencephalography and psychoacoustics. All disorder subgroups exhibited an oversized left planum temporale and an abnormal interhemispheric asynchrony (10-40 ms) of the primary auditory evoked P1-response. Considering right auditory cortex morphology, bilateral P1 source waveform shapes, and auditory performance, the three disorder subgroups could be reliably differentiated with outstanding accuracies of 89-98%. We therefore for the first time provide differential biomarkers for a brain-based diagnosis of dyslexia, ADHD, and ADD. The method allowed not only allowed for clear discrimination between two subtypes of attentional disorders (ADHD and ADD), a topic controversially discussed for decades in the scientific community, but also revealed the potential for objectively identifying comorbid cases. Noteworthy, in children playing a musical instrument, after three and a half years of training the observed interhemispheric asynchronies were reduced by about 2/3, thus suggesting a strong beneficial influence of music experience on brain development. These findings might have far-reaching implications for both research and practice and enable a profound understanding of the brain-related etiology, diagnosis, and musically based therapy of common auditory-related developmental disorders and learning disabilities. PMID:27471442

  8. Neural Biomarkers for Dyslexia, ADHD, and ADD in the Auditory Cortex of Children

    PubMed Central

    Serrallach, Bettina; Groß, Christine; Bernhofs, Valdis; Engelmann, Dorte; Benner, Jan; Gündert, Nadine; Blatow, Maria; Wengenroth, Martina; Seitz, Angelika; Brunner, Monika; Seither, Stefan; Parncutt, Richard; Schneider, Peter; Seither-Preisler, Annemarie

    2016-01-01

    Dyslexia, attention deficit hyperactivity disorder (ADHD), and attention deficit disorder (ADD) show distinct clinical profiles that may include auditory and language-related impairments. Currently, an objective brain-based diagnosis of these developmental disorders is still unavailable. We investigated the neuro-auditory systems of dyslexic, ADHD, ADD, and age-matched control children (N = 147) using neuroimaging, magnetencephalography and psychoacoustics. All disorder subgroups exhibited an oversized left planum temporale and an abnormal interhemispheric asynchrony (10–40 ms) of the primary auditory evoked P1-response. Considering right auditory cortex morphology, bilateral P1 source waveform shapes, and auditory performance, the three disorder subgroups could be reliably differentiated with outstanding accuracies of 89–98%. We therefore for the first time provide differential biomarkers for a brain-based diagnosis of dyslexia, ADHD, and ADD. The method allowed not only allowed for clear discrimination between two subtypes of attentional disorders (ADHD and ADD), a topic controversially discussed for decades in the scientific community, but also revealed the potential for objectively identifying comorbid cases. Noteworthy, in children playing a musical instrument, after three and a half years of training the observed interhemispheric asynchronies were reduced by about 2/3, thus suggesting a strong beneficial influence of music experience on brain development. These findings might have far-reaching implications for both research and practice and enable a profound understanding of the brain-related etiology, diagnosis, and musically based therapy of common auditory-related developmental disorders and learning disabilities. PMID:27471442

  9. Family Numeracy Adds on: The Follow-Up Study of the Basic Skills Agency's Pilot Programme

    ERIC Educational Resources Information Center

    Brooks, Greg; Hutchison, Dougal

    2002-01-01

    In 1998 the authors published research with NFER (National Foundation for Educational Research) "Family Numeracy Adds Up" showing how parents and children had gained from fourteen pilot family numeracy programmes. It showed strong evidence of the double benefits of work with families. Children have an early boost in their learning and parents, who…

  10. 40 CFR 75.34 - Units with add-on emission controls.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 17 2012-07-01 2012-07-01 false Units with add-on emission controls. 75.34 Section 75.34 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTINUOUS EMISSION MONITORING Missing Data Substitution Procedures § 75.34 Units...

  11. 40 CFR 75.34 - Units with add-on emission controls.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 17 2013-07-01 2013-07-01 false Units with add-on emission controls. 75.34 Section 75.34 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTINUOUS EMISSION MONITORING Missing Data Substitution Procedures § 75.34 Units...

  12. Civic Engagement and Global Citizenship in a University Context: Core Business or Desirable Add-On?

    ERIC Educational Resources Information Center

    Munck, Ronaldo

    2010-01-01

    Can civic engagement become a "core business" of the contemporary university, or is it an attractive "add-on" that is not affordable in the current economic climate? Contemporary universities often play an important role in local community development and, as such, have the opportunity to develop civic engagement strategies to sit alongside…

  13. Project DyAdd: Implicit Learning in Adult Dyslexia and ADHD

    ERIC Educational Resources Information Center

    Laasonen, Marja; Väre, Jenni; Oksanen-Hennah, Henna; Leppämäki, Sami; Tani, Pekka; Harno, Hanna; Hokkanen, Laura; Pothos, Emmanuel; Cleeremans, Axel

    2014-01-01

    In this study of the project DyAdd, implicit learning was investigated through two paradigms in adults (18-55 years) with dyslexia (n?=?36) or with attention deficit/hyperactivity disorder (ADHD, n?=?22) and in controls (n?=?35). In the serial reaction time (SRT) task, there were no group differences in learning. However, those with ADHD exhibited…

  14. Add+VantageMR® Assessments: A Case Study of Teacher and Student Gains

    ERIC Educational Resources Information Center

    Briand, Cathy

    2013-01-01

    This case study analyzes the effect of the Add+VantageMRRTM (AVMR) program on a teacher's pedagogy and on her students' progress in mathematics. AVMR, a professional development program in early mathematics, trains teachers to assess their students' progress and apply those insights to their teaching pedagogy. The AVMR assessment uses a…

  15. ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome

    SciTech Connect

    Iwase, Shigeki; Xiang, Bin; Ghosh, Sharmistha; Ren, Ting; Lewis, Peter W.; Cochrane, Jesse C.; Allis, C. David; Picketts, David J.; Patel, Dinshaw J.; Li, Haitao; Shi, Yang

    2011-07-19

    ATR-X (alpha-thalassemia/mental retardation, X-linked) syndrome is a human congenital disorder that causes severe intellectual disabilities. Mutations in the ATRX gene, which encodes an ATP-dependent chromatin-remodeler, are responsible for the syndrome. Approximately 50% of the missense mutations in affected persons are clustered in a cysteine-rich domain termed ADD (ATRX-DNMT3-DNMT3L, ADD{sub ATRX}), whose function has remained elusive. Here we identify ADD{sub ATRX} as a previously unknown histone H3-binding module, whose binding is promoted by lysine 9 trimethylation (H3K9me3) but inhibited by lysine 4 trimethylation (H3K4me3). The cocrystal structure of ADD{sub ATRX} bound to H3{sub 1-15}K9me3 peptide reveals an atypical composite H3K9me3-binding pocket, which is distinct from the conventional trimethyllysine-binding aromatic cage. Notably, H3K9me3-pocket mutants and ATR-X syndrome mutants are defective in both H3K9me3 binding and localization at pericentromeric heterochromatin; thus, we have discovered a unique histone-recognition mechanism underlying the ATR-X etiology.

  16. 24 CFR 990.190 - Other formula expenses (add-ons).

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 4 2012-04-01 2012-04-01 false Other formula expenses (add-ons). 990.190 Section 990.190 Housing and Urban Development REGULATIONS RELATING TO HOUSING AND URBAN DEVELOPMENT (CONTINUED) OFFICE OF ASSISTANT SECRETARY FOR PUBLIC AND INDIAN HOUSING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT THE PUBLIC...

  17. In Building a Script for an Emotion, Do Preschoolers Add Its Cause before Its Behavior Consequence?

    ERIC Educational Resources Information Center

    Widen, Sherri C.; Russell, James A.

    2011-01-01

    An emotion concept is a script in which an emotion event is an ordered sequence of subevents from situational cause through bodily changes to behavioral consequence. As children build a script for each emotion, in what order do they add each subevent? Preschoolers (N = 108, three to five years), were asked to name the protagonist's emotion in…

  18. Associations between Dopamine and Serotonin Genes and Job Satisfaction: Preliminary Evidence from the Add Health Study

    ERIC Educational Resources Information Center

    Song, Zhaoli; Li, Wendong; Arvey, Richard D.

    2011-01-01

    Previous behavioral genetic studies have found that job satisfaction is partially heritable. We went a step further to examine particular genetic markers that may be associated with job satisfaction. Using an oversample from the National Adolescent Longitudinal Study (Add Health Study), we found 2 genetic markers, dopamine receptor gene DRD4 VNTR…

  19. ATRX ADD Domain Links an Atypical Histone Methylation Recognition Mechanism to Human Mental-Retardation Syndrome

    SciTech Connect

    S Iwase; B Xiang; S Ghosh; T Ren; P Lewis; J Cochrane; C Allis; D Picketts; D Patel; et al.

    2011-12-31

    ATR-X (alpha-thalassemia/mental retardation, X-linked) syndrome is a human congenital disorder that causes severe intellectual disabilities. Mutations in the ATRX gene, which encodes an ATP-dependent chromatin-remodeler, are responsible for the syndrome. Approximately 50% of the missense mutations in affected persons are clustered in a cysteine-rich domain termed ADD (ATRX-DNMT3-DNMT3L, ADD{sub ATRX}), whose function has remained elusive. Here we identify ADD{sub ATRX} as a previously unknown histone H3-binding module, whose binding is promoted by lysine 9 trimethylation (H3K9me3) but inhibited by lysine 4 trimethylation (H3K4me3). The cocrystal structure of ADD{sub ATRX} bound to H3{sub 1-15}K9me3 peptide reveals an atypical composite H3K9me3-binding pocket, which is distinct from the conventional trimethyllysine-binding aromatic cage. Notably, H3K9me3-pocket mutants and ATR-X syndrome mutants are defective in both H3K9me3 binding and localization at pericentromeric heterochromatin; thus, we have discovered a unique histone-recognition mechanism underlying the ATR-X etiology.

  20. 24 CFR 983.206 - HAP contract amendments (to add or substitute contract units).

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... new PBV request for proposals is not required. The anniversary and expiration dates of the HAP contract for the additional units must be the same as the anniversary and expiration dates of the HAP... execution date of the HAP contract to add additional PBV contract units in the same building. An...

  1. 24 CFR 983.206 - HAP contract amendments (to add or substitute contract units).

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... new PBV request for proposals is not required. The anniversary and expiration dates of the HAP contract for the additional units must be the same as the anniversary and expiration dates of the HAP... execution date of the HAP contract to add additional PBV contract units in the same building. An...

  2. The Use of Compensated Aerological No-Lift Balloons to Determine Relatively Long-Term Dry-Air Parcel Trajectories.

    NASA Astrophysics Data System (ADS)

    Terliuc, Benjamin; Asculai, Ephraim; Doron, Eli

    1983-10-01

    A method to compensate the loss of buoyancy due to gas leakage from aerological no-lift balloons is presented. The method is implemented by means of a double vessel device that supplies a constant liquid outflow at constant temperature. It is shown that the average buoyancy loss rate dependence on temperature is almost perfectly matched by the outflow rate dependence on temperature when soya-bean oil is used. The device is simple, inexpensive and can be easily manufactured using standard laboratory equipment.A simple and safe method to carry no-lift systems to prefixed levels is also presented. It is based on a single 30 g pilot balloon provided with a gas leakage nozzle, inflated with H2 to a calibrated initial free-lift. The balloon is totally emptied at the required level, and remains suspended from the no-lift system.The whole system can be easily prepared under field conditions to be used in long travel-time studies of dry-air parcel trajectories in the atmosphere.An example of the use of the improved method over complex terrain is presented. A no-lift system provided with a 1680 MHz radiosonde transmitter, was tracked by two RD-65 radio-theodolites, to investigate the effects of the topographic structure of the Lake Kinneret (Sea of Galilee) area on the Mediterranean sea breeze summer regime. The system was tracked for at least one hour, following a trajectory with severe vertical variations. This increases our confidence in the ability to track much longer trajectories, if required.

  3. Formation of ozone and growth of aerosols in young smoke plumes from biomass burning: 1. Lagrangian parcel studies

    NASA Astrophysics Data System (ADS)

    Alvarado, Matthew James; Prinn, Ronald G.

    2009-05-01

    We have developed a new model of the gas- and aerosol-phase chemistry of biomass burning smoke plumes called Aerosol Simulation Program (ASP). Here we use ASP combined with a Lagrangian parcel model to simulate the chemistry in smoke plumes from three fires: the Otavi savannah fire in Namibia, an Alaska boreal forest fire, and the Timbavati savannah fire. Our model explained the observations of ozone in the Otavi and Alaska plumes fairly well, but our initial model simulation of the Timbavati plume underestimated the concentrations of ozone, OH, and secondary aerosol matter. The Timbavati simulation agrees with observations if we increase OH to equal its observed levels. Heterogeneous reactions of NO2 and SO2 could explain the needed higher concentrations of OH and the rapid formation of ozone, nitrate, and sulfate in the smoke plume if the uptake coefficients on smoke aerosols are large (O(10-3) and O(10-4), respectively). Uncharacterized organic species in the smoke plume were likely responsible for the rapid formation of aerosol organic carbon. The changes in the aerosol size distribution were dominated by plume dilution and condensational growth. The single scattering albedo of the modeled smoke increases from 0.866 to 0.902 over 1 h of aging. The change in aerosol scattering with relative humidity for the modeled fresh smoke matches observations up to 66% RH, but the model greatly overestimates the humidification factor at 80% RH (2.88 versus an observed value of 1.70-1.79). For the aged smoke, the modeled humidification factor is 1.22, slightly below the observed value of 1.40.

  4. Connectivity-Based Parcellation of the Thalamus Explains Specific Cognitive and Behavioural Symptoms in Patients with Bilateral Thalamic Infarct

    PubMed Central

    Serra, Laura; Cercignani, Mara; Carlesimo, Giovanni A.; Fadda, Lucia; Tini, Nadia; Giulietti, Giovanni; Caltagirone, Carlo; Bozzali, Marco

    2013-01-01

    A novel approach based on diffusion tractography was used here to characterise the cortico-thalamic connectivity in two patients, both presenting with an isolated bilateral infarct in the thalamus, but exhibiting partially different cognitive and behavioural profiles. Both patients (G.P. and R.F.) had a pervasive deficit in episodic memory, but only one of them (R.F.) suffered also from a dysexecutive syndrome. Both patients had an MRI scan at 3T, including a T1-weighted volume. Their lesions were manually segmented. T1-volumes were normalised to standard space, and the same transformations were applied to the lesion masks. Nineteen healthy controls underwent a diffusion-tensor imaging (DTI) scan. Their DTI data were normalised to standard space and averaged. An atlas of Brodmann areas was used to parcellate the prefrontal cortex. Probabilistic tractography was used to assess the probability of connection between each voxel of the thalamus and a set of prefrontal areas. The resulting map of corticothalamic connections was superimposed onto the patients’ lesion masks, to assess whether the location of the thalamic lesions in R.F. (but not in G. P.) implied connections with prefrontal areas involved in dysexecutive syndromes. In G.P., the lesion fell within areas of the thalamus poorly connected with prefrontal areas, showing only a modest probability of connection with the anterior cingulate cortex (ACC). Conversely, R.F.’s lesion fell within thalamic areas extensively connected with the ACC bilaterally, with the right dorsolateral prefrontal cortex, and with the left supplementary motor area. Despite a similar, bilateral involvement of the thalamus, the use of connectivity-based segmentation clarified that R.F.’s lesions only were located within nuclei highly connected with the prefrontal cortical areas, thus explaining the patient’s frontal syndrome. This study confirms that DTI tractography is a useful tool to examine in vivo the effect of focal lesions

  5. Study protocol for the randomised controlled trial: Antiglucocorticoid augmentation of anti-Depressants in Depression (The ADD Study)

    PubMed Central

    2013-01-01

    Background Some patients with depression do not respond to first and second line conventional antidepressants and are therefore characterised as suffering from treatment refractory depression (TRD). On-going psychosocial stress and dysfunction of the hypothalamic-pituitary-adrenal axis are both associated with an attenuated clinical response to antidepressants. Preclinical data shows that co-administration of corticosteroids leads to a reduction in the ability of selective serotonin reuptake inhibitors to increase forebrain 5-hydroxytryptamine, while co-administration of antiglucocorticoids has the opposite effect. A Cochrane review suggests that antiglucocorticoid augmentation of antidepressants may be effective in treating TRD and includes a pilot study of the cortisol synthesis inhibitor, metyrapone. The Antiglucocorticoid augmentation of anti-Depressants in Depression (The ADD Study) is a multicentre randomised placebo controlled trial of metyrapone augmentation of serotonergic antidepressants in a large population of patients with TRD in the UK National Health Service. Methods/design Patients with moderate to severe treatment refractory Major Depression aged 18 to 65 will be randomised to metyrapone 500 mg twice daily or placebo for three weeks, in addition to on-going conventional serotonergic antidepressants. The primary outcome will be improvement in Montgomery-Åsberg Depression Rating Scale score five weeks after randomisation (i.e. two weeks after trial medication discontinuation). Secondary outcomes will include the degree of persistence of treatment effect for up to 6 months, improvements in quality of life and also safety and tolerability of metyrapone. The ADD Study will also include a range of sub-studies investigating the potential mechanism of action of metyrapone. Discussion Strengths of the ADD study include broad inclusion criteria meaning that the sample will be representative of patients with TRD treated within the UK National Health

  6. Proposed helmet PET geometries with add-on detectors for high sensitivity brain imaging

    NASA Astrophysics Data System (ADS)

    Tashima, Hideaki; Yamaya, Taiga

    2016-10-01

    For dedicated brain PET, we can significantly improve sensitivity for the cerebrum region by arranging detectors in a compact hemisphere. The geometrical sensitivity for the top region of the hemisphere is increased compared with conventional cylindrical PET consisting of the same number of detectors. However, the geometrical sensitivity at the center region of the hemisphere is still low because the bottom edge of the field-of-view is open, the same as for the cylindrical PET. In this paper, we proposed a helmet PET with add-on detectors for high sensitivity brain PET imaging for both center and top regions. The key point is the add-on detectors covering some portion of the spherical surface in addition to the hemisphere. As the location of the add-on detectors, we proposed three choices: a chin detector, ear detectors, and a neck detector. For example, the geometrical sensitivity for the region-of-interest at the center was increased by 200% by adding the chin detector which increased the size by 12% of the size of the hemisphere detector. The other add-on detectors gave almost the same increased sensitivity effect as the chin detector did. Compared with standard whole-body-cylindrical PET, the proposed geometries can achieve 2.6 times higher sensitivity for brain region even with less than 1/4 detectors. In addition, we conducted imaging simulations for geometries with a diameter of 250 mm and with high resolution depth-of-interaction detectors. The simulation results showed that the proposed geometries increased image quality, and all of the add-on detectors were equivalently effective. In conclusion, the proposed geometries have high potential for widespread applications in high-sensitivity, high-resolution, and low-cost brain PET imaging.

  7. ENVIRONMENTAL BASELINE SURVEY REPORT FOR WEST BLACK OAK RIDGE, EAST BLACK OAK RIDGE, MCKINNEY RIDGE, WEST PINE RIDGE, AND PARCEL 21D IN THE VICINITY OF THE EAST TENNESSEE TECHNOLOGY PARK, OAK RIDGE, TENNESSEE

    SciTech Connect

    David A. King

    2012-11-29

    This environmental baseline survey (EBS) report documents the baseline environmental conditions of five land parcels located near the U.S. Department of Energy’s (DOE’s) East Tennessee Technology Park (ETTP), including West Black Oak Ridge, East Black Oak Ridge, McKinney Ridge, West Pine Ridge, and Parcel 21d. The goal is to obtain all media no-further-investigation (NFI) determinations for the subject parcels considering existing soils. To augment the existing soils-only NFI determinations, samples of groundwater, surface water, soil, and sediment were collected to support all media NFI decisions. The only updates presented here are those that were made after the original issuance of the NFI documents. In the subject parcel where the soils NFI determination was not completed for approval (Parcel 21d), the full process has been performed to address the soils as well. Preparation of this report included the detailed search of federal government records, title documents, aerial photos that may reflect prior uses, and visual inspections of the property and adjacent properties. Interviews with current employees involved in, or familiar with, operations on the real property were also conducted to identify any areas on the property where hazardous substances and petroleum products, or their derivatives, and acutely hazardous wastes may have been released or disposed. In addition, a search was made of reasonably obtainable federal, state, and local government records of each adjacent facility where there has been a release of any hazardous substance or any petroleum product or their derivatives, including aviation fuel and motor oil, and which is likely to cause or contribute to a release of any hazardous substance or any petroleum product or its derivatives, including aviation fuel or motor oil, on the real property. A radiological survey and soil/sediment sampling was conducted to assess baseline conditions of Parcel 21d that were not addressed by the soils-only NFI

  8. Analysis of reconfigurable multi-channel wavelength add drop multiplexer for intelligent optical networks

    NASA Astrophysics Data System (ADS)

    Ponmalar, S.; Sundaravadivelu, S.

    2011-07-01

    This paper presents design of an electro-optically tunable polymer multi-channel wavelength add drop multiplexer (WADM). The proposed WADM with trapezoidal waveguide geometry and poled electro-optical polymer material in the waveguide cores enables the wavelength tuning speed of WADM as 7.5 ps at the resonance wavelength of 1550 nm and coupling length of 1.5 mm. The device can be electro-optically tuned to add/drop multiple channels. Transmission spectra of the device with varying device parameters are simulated. The proposed WADM with high speed, small size and varying tuning capability makes this device, an important element in faster provisioning and routing of light paths in intelligent optical network.

  9. Processing Speed Weakness in Children and Adolescents with Non-Hyperactive but Inattentive ADHD (ADD)

    PubMed Central

    Goth-Owens, Timothy L.; Martinez-Torteya, Cecilia; Martel, Michelle M.; Nigg, Joel T.

    2010-01-01

    DSM-IV-TR defines ADHD-Predominantly Inattentive as allowing up to five symptoms of hyperactivity/impulsivity, while theories of the inattentive type usually assume a group that is hypoactive and characterized by processing speed and cognitive interference deficits. In a community-recruited sample of 572 children and adolescents, a pure inattentive subtype of ADHD (ADD) was defined as those who met DSM-IV-TR criteria for ADHD-PI but had two or fewer hyperactive/impulsive symptoms. Processing and output speeds of those with ADD were compared to those identified with DSM-IV-TR ADHD combined type and non-ADHD controls. These results were then contrasted with those found when DSM-IV-TR defined ADHD-PI was compared with ADHD-C and controls. Processing and output speed were assessed with the Trailmaking A and B and the Stroop Naming Tests. Cognitive interference control was assessed with the interference score from the Stroop Task. Slower cognitive interference speed was found in the ADD vs. ADHD-C and controls comparisons, but not the ADHD-PI versus ADHD-C and controls comparisons. On output speed measures, ADD exhibited the slowest performance, significantly different from controls and the effect size for the set-shifting speed contrast (Trailmaking B) contrast was double that of the ADHD-PI vs. control comparison. ADHD-Inattentive type as defined by the DSM-IV-TR is a heterogeneous condition with a meaningful proportion of those affected exhibiting virtually no hyperactive/impulsive symptoms. This subgroup may represent a distinct inattentive condition characterized by poor cognitive interference control and slow processing or output speed. PMID:20560083

  10. Add on testosterone therapy in negative symptoms of schizophrenia with gonadal trauma: Hitting the bull's eye.

    PubMed

    Jha, Shailesh; Garg, Amit

    2016-06-30

    The coincidence or causal incidence of hormonal dysregulation leading to psychotic manifestation had been a point of debate. The interplay of these hormones in pathogenesis of psychotic symptom domains is still inconclusive along with some symptom domains which worsen with antipsychotics. Early detection and treatment with liaison approach is of great help to such patients. We report a case of schizophrenia with primary hypogonadism that responded dramatically to add on testosterone supplement. PMID:27138816

  11. Improving stable isotope-based reconstructions of Sierra Nevada paleotopography using insights from regional air parcel trajectories

    NASA Astrophysics Data System (ADS)

    Lechler, A.; Galewsky, J.

    2012-12-01

    The geodynamic evolution of the Sierra Nevada Mountains of the western US remains subject to debate due to the lack of consensus on the Cenozoic paleoelevation history of the range. The majority of recent studies attempting to quantify the surface uplift history of the Sierra Nevada rely on stable isotope paleoaltimetry methods that often implicitly assume that atmospheric flow interactions with topography can be simply modeled as a Rayleigh distillation process in which air mass trajectories ascend and rainout heavy isotopologues of water (18O and D) across topographic barriers relatively unimpeded. Accordingly, stable isotope paleoaltimetry studies commonly target leeward side paleo-meteoric water proxies to constrain paleotopography of the windward barrier. We present a modern (1979 - 2010) air parcel trajectory analysis using the Hybrid Single Particle Lagrangian Integrated Trajectory (HYSPLIT) model that shows that the fundamental assumptions of stable isotope paleoaltimetry are often violated in the Sierra Nevada region. Trajectory analysis indicates that westerly air masses are frequently orographically blocked by and redirected around the higher elevations (> 2.5 km) of the Sierra Nevada. As a result, trajectories reaching the Sierran lee commonly travel around, rather than over, the highest range elevations. These blocking and redirection effects are particularly pronounced for leeward sites that are distal (> 150 km) from the Sierran crest but are also evident in trajectory patterns for both windward and proximal leeward locations in the northern Sierra Nevada. In addition, trajectory patterns indicate that much of the Sierran lee receives a non-negligible proportion of annual precipitation from summer storm systems sourced in the subtropical Pacific Ocean and Gulf of California that have little to no interaction with Sierran topography. This trajectory analysis highlights the complexity of orographic precipitation patterns and processes in the Sierra

  12. Parceling the Power.

    ERIC Educational Resources Information Center

    Hiatt, Blanchard; Gwynne, Peter

    1984-01-01

    To make computing power broadly available and truly friendly, both soft and hard meshing and synchronization problems will have to be solved. Possible solutions and research related to these problems are discussed. Topics considered include compilers, parallelism, networks, distributed sensors, dataflow, CEDAR system (using dataflow principles),…

  13. Relationship between apparent soil electrical conductivity (ECa) and soil attributes at an experimental parcel under pasture in a region of Galicia, Spain.

    NASA Astrophysics Data System (ADS)

    Marinho, Mara de A.; Dafonte, Jorge D.; Armesto, Montserrat V.; Paz-González, Antonio; Raposo, Juan R.

    2013-04-01

    Spatial characterization of the variability of soil properties is a central point in site-specific agricultural management and precision agriculture. Geospatial measures of geophysical attributes are useful not only to rapidly characterize the spatial variability of soil properties but also for soil sampling optimization. This work reports partial results obtained at an experimental parcel under pasture located at Castro de Ribeira do Lea (Lugo/ Galicia/ Spain). An ECa automated survey was conducted in September 2011 employing an EM-38 DD (Geonics Ltd.) installed in a nonmetallic car, according to parallel lines spaced 10m one from each other and oriented at the east-west direction. The ECa values were recorded every second with a field computer and the locations were geo-referenced using a GPS. The entire survey was carried out in 1hour and 45 minutes and corrections due to differences in temperature were made. A total of 9.581 ECa registers were retained, configuring a sampling intensity of approximately 1 register per 1.5 m2. Employing the software ESAP 2.35 and the computational tool ESAP-RSSD, eighty positions were selected at the field to extract disturbed and undisturbed soil samples at two depths: 0.0-0.2m, 0.2-0.4m. Ten physical attributes (clay, silt, total sand, coarse sand and fine sand contents, soil bulk density, particle density, total porosity, soil water content, percentage of gravels) and 17 chemical attributes (soil organic matter-SOM, pH, P, K, Ca, Mg, Al, H+Al, Sum of bases-S, Cation exchange capacity-CEC, Base saturation-V%, Cd, Cr, Cu, Fe, Mn, Ni, Pb and Zn) were determined. The relationship between the geophysical variables and the soil attributes was performed using statistical and spatial analysis. There were significant correlations (p<0.01) between the geophysical variables and the textural attributes clay, silt, total sand and coarse sand contents. The biggest correlation (0.5623) was between ECa-V (vertical component) and clay content

  14. THERIAK_D: An add-on to implement equilibrium computations in geodynamic models

    NASA Astrophysics Data System (ADS)

    Duesterhoeft, Erik; Capitani, Christian

    2013-11-01

    This study presents the theory, applicability, and merits of the new THERIAK_D add-on for the open source Theriak/Domino software package. The add-on works as an interface between Theriak and user-generated scripts, providing the opportunity to process phase equilibrium computation parameters in a programming environment (e.g., C or MATLAB®). THERIAK_D supports a wide range of features such as calculating the solid rock density or testing the stability of mineral phases along any pressure-temperature (P-T) path and P-T grid. To demonstrate applicability, an example is given in which the solid rock density of a 2-D-temperature-pressure field is calculated, portraying a simplified subduction zone. Consequently, the add-on effectively combines thermodynamics and geodynamic modeling. The carefully documented examples could be easily adapted for a broad range of applications. THERIAK_D is free, and the program, user manual, and source codes may be downloaded from http://www.min.uni-kiel.de/˜ed/theriakd/.

  15. radEq Add-On Module for CFD Solver Loci-CHEM

    NASA Technical Reports Server (NTRS)

    McCloud, Peter

    2013-01-01

    Loci-CHEM to be applied to flow velocities where surface radiation due to heating from compression and friction becomes significant. The module adds a radiation equilibrium boundary condition to the computational fluid dynamics (CFD) code to produce accurate results. The module expanded the upper limit for accurate CFD solutions of Loci-CHEM from Mach 4 to Mach 10 based on Space Shuttle Orbiter Re-Entry trajectories. Loci-CHEM already has a very promising architecture and performance, but absence of radiation equilibrium boundary condition limited the application of Loci-CHEM to below Mach 4. The immediate advantage of the add-on module is that it allows Loci-CHEM to work with supersonic flows up to Mach 10. This transformed Loci-CHEM from a rocket engine- heritage CFD code with general subsonic and low-supersonic applications, to an aeroheating code with hypersonic applications. The follow-on advantage of the module is that it is a building block for additional add-on modules that will solve for the heating generated at Mach numbers higher than 10.

  16. The dubious assessment of gay, lesbian, and bisexual adolescents of add health.

    PubMed

    Savin-Williams, Ritch C; Joyner, Kara

    2014-04-01

    In this essay, we argue that researchers who base their investigations of nonheterosexuality derived from reports of romantic attractions of adolescent participants from Wave 1 of Add Health must account for their disappearance in future waves of data collection. The high prevalence of Wave 1 youth with either both-sex or same-sex romantic attractions was initially striking and unexpected. Subsequent data from Add Health indicated that this prevalence sharply declined over time such that over 70 % of these Wave 1 adolescents identified as exclusively heterosexual as Wave 4 young adults. Three explanations are proposed to account for the high prevalence rate and the temporal inconsistency: (1) gay adolescents going into the closet during their young adult years; (2) confusion regarding the use and meaning of romantic attraction as a proxy for sexual orientation; and (3) the existence of mischievous adolescents who played a "jokester" role by reporting same-sex attraction when none was present. Relying on Add Health data, we dismissed the first explanation as highly unlikely and found support for the other two. Importantly, these "dubious" gay, lesbian, and bisexual adolescents may have led researchers to erroneously conclude from the data that sexual-minority youth are more problematic than heterosexual youth in terms of physical, mental, and social health.

  17. 76 FR 37114 - Determination Concerning a Petition To Add a Class of Employees to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-24

    ... HUMAN SERVICES Determination Concerning a Petition To Add a Class of Employees to the Special Exposure... Human Services (HHS). ACTION: Notice. SUMMARY: HHS gives notice of a determination concerning a petition to add a class of employees from the Dow Chemical Company in Madison, Illinois, to the...

  18. The MMPI-168(L) and ADD in Assessing Psychopathology in Individuals with Mental Retardation: Between and within Instrument Associations.

    ERIC Educational Resources Information Center

    McDaniel, William F.; Passmore, Corie E.; Sewell, Hollie M.

    2003-01-01

    A study involving 58 adults with mental retardation and mental disorders found few correlations between the Minnesota Multiphasic Personality Inventory (MMPI) and the Assessment of Dual Diagnosis (ADD). The major exception was the Mania scale of the MMPI, which correlated moderately well with the ADD Schizophrenia and Dementia scales. (Contains…

  19. 31 CFR 5.5 - How will Treasury entities add interest, penalty charges, and administrative costs to a Treasury...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... administrative costs on Treasury debts in accordance with the provisions of 31 U.S.C. 3717 and 31 CFR 901.9, on... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false How will Treasury entities add... Debts § 5.5 How will Treasury entities add interest, penalty charges, and administrative costs to...

  20. 43 CFR 3283.4 - When may the unit operator add lands to or remove lands from a unit agreement?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false When may the unit operator add lands to or remove lands from a unit agreement? 3283.4 Section 3283.4 Public Lands: Interior Regulations Relating to... add lands to or remove lands from a unit agreement? (a) The unit operator may request BLM to...

  1. 78 FR 98 - Determination Concerning a Petition To Add a Class of Employees to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-02

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF HEALTH AND HUMAN SERVICES Determination Concerning a Petition To Add a Class of Employees to the Special Exposure... notice of a determination concerning a petition to add a class of employees from the United...

  2. 40 CFR Table 1 to Subpart Jjjj of... - Operating Limits if Using Add-On Control Devices and Capture System

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 12 2011-07-01 2009-07-01 true Operating Limits if Using Add-On Control Devices and Capture System 1 Table 1 to Subpart JJJJ of Part 63 Protection of Environment... Limits if Using Add-On Control Devices and Capture System If you are required to comply with...

  3. 40 CFR Table 1 to Subpart Ssss of... - Operating Limits if Using Add-on Control Devices and Capture System

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Operating Limits if Using Add-on Control Devices and Capture System 1 Table 1 to Subpart SSSS of Part 63 Protection of Environment... Using Add-on Control Devices and Capture System If you are required to comply with operating limits...

  4. 36 CFR 1011.5 - What interest, penalty charges and administrative costs will the Presidio Trust add to a debt?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 3 2011-07-01 2011-07-01 false What interest, penalty charges and administrative costs will the Presidio Trust add to a debt? 1011.5 Section 1011.5 Parks... § 1011.5 What interest, penalty charges and administrative costs will the Presidio Trust add to a...

  5. 31 CFR 5.5 - How will Treasury entities add interest, penalty charges, and administrative costs to a Treasury...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... administrative costs on Treasury debts in accordance with the provisions of 31 U.S.C. 3717 and 31 CFR 901.9, on... 31 Money and Finance: Treasury 1 2011-07-01 2011-07-01 false How will Treasury entities add... Debts § 5.5 How will Treasury entities add interest, penalty charges, and administrative costs to...

  6. 77 FR 76490 - Determination Concerning a Petition to Add a Class of Employees to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-28

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Determination Concerning a Petition to Add a Class of Employees to the Special Exposure... notice of a determination concerning a petition to add a class of employees from the Weldon Spring...

  7. 40 CFR Table 2 to Subpart Oooo of... - Operating Limits if Using Add-On Control Devices and Capture System

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 12 2011-07-01 2009-07-01 true Operating Limits if Using Add-On Control Devices and Capture System 2 Table 2 to Subpart OOOO of Part 63 Protection of Environment... OOOO of Part 63—Operating Limits if Using Add-On Control Devices and Capture System If you are...

  8. 78 FR 18351 - Determination Concerning a Petition To Add a Class of Employees to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-26

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Determination Concerning a Petition To Add a Class of Employees to the Special Exposure... notice of a determination concerning a petition to add a class of employees from the Hanford site...

  9. 40 CFR Table 1 to Subpart Ssss of... - Operating Limits if Using Add-on Control Devices and Capture System

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 12 2011-07-01 2009-07-01 true Operating Limits if Using Add-on Control Devices and Capture System 1 Table 1 to Subpart SSSS of Part 63 Protection of Environment... Using Add-on Control Devices and Capture System If you are required to comply with operating limits...

  10. 77 FR 58383 - Determination Concerning a Petition To Add a Class of Employees to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-20

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF HEALTH AND HUMAN SERVICES Determination Concerning a Petition To Add a Class of Employees to the Special Exposure... notice of a determination concerning a petition to add a class of employees from Titanium...

  11. 76 FR 65763 - Self-Regulatory Organizations; ICE Clear Credit LLC; Order Approving Proposed Rule Change To Add...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-24

    ...-65259 (September 2, 2011), 76 FR 55984 (September 9, 2011). In its filing with the Commission, ICC... COMMISSION Self-Regulatory Organizations; ICE Clear Credit LLC; Order Approving Proposed Rule Change To Add.... Description This rule change will amend Chapter 26 of ICC's rules to add Sections 26D and 26E to provide...

  12. 15 CFR 19.5 - How will Commerce entities add interest, penalty charges, and administrative costs to a Commerce...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... administrative costs on Commerce debts in accordance with the provisions of 31 U.S.C. 3717 and 31 CFR 901.9... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false How will Commerce entities add... Debts § 19.5 How will Commerce entities add interest, penalty charges, and administrative costs to...

  13. 77 FR 76490 - Determination Concerning a Petition to Add a Class of Employees to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-28

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Determination Concerning a Petition to Add a Class of Employees to the Special Exposure... notice of a determination concerning a petition to add a class of employees from the Mound Plant...

  14. 76 FR 70148 - Determination Concerning a Petition To Add a Class of Employees to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-10

    ... HUMAN SERVICES Determination Concerning a Petition To Add a Class of Employees to the Special Exposure... Human Services (HHS). ACTION: Notice. SUMMARY: HHS gives notice of a determination concerning a petition to add a class of employees from the Norton Co. (or a subsequent owner), Worcester, Massachusetts,...

  15. 78 FR 64502 - Determination Concerning a Petition To Add a Class of Employees to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-29

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF HEALTH AND HUMAN SERVICES Determination Concerning a Petition To Add a Class of Employees to the Special Exposure... notice of a determination concerning a petition to add a class of employees from the Pantex Plant...

  16. 76 FR 70147 - Determination Concerning a Petition To Add a Class of Employees to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-10

    ... HUMAN SERVICES Determination Concerning a Petition To Add a Class of Employees to the Special Exposure... Human Services (HHS). ACTION: Notice. SUMMARY: HHS gives notice of a determination concerning a petition to add a class of employees from the Piqua Organic Moderated Reactor, Piqua, Ohio, to the...

  17. 78 FR 64501 - Determination Concerning a Petition to Add a Class of Employees to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-29

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Determination Concerning a Petition to Add a Class of Employees to the Special Exposure... notice of a determination concerning a petition to add a class of employees from Baker Brothers,...

  18. 78 FR 36550 - Determination Concerning a Petition To Add a Class of Employees to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-18

    ... notice of a determination concerning a petition to add a class of employees from the Brookhaven National Laboratory in Upton, New York, to the Special Exposure Cohort (SEC) under the Energy Employees Occupational... HUMAN SERVICES Determination Concerning a Petition To Add a Class of Employees to the Special...

  19. Environmental Baseline Survey Report for the Title Transfer of Parcel ED-9 at the East Tennessee Technology Park, Oak Ridge, Tennessee

    SciTech Connect

    SAIC

    2010-05-01

    This environmental baseline survey (EBS) report documents the baseline environmental conditions of the U. S. Department of Energy's (DOE's) Parcel ED-9 at the East Tennessee Technology Park (ETTP). Parcel ED-9 consists of about 13 acres that DOE proposes to transfer to Heritage Center, LLC (hereafter referred to as 'Heritage Center'), a subsidiary of the Community Reuse Organization of East Tennessee (CROET). The 13 acres include two tracts of land, referred to as ED-9A (7.06 acres) and ED-9B (5.02 acres), and a third tract consisting of about 900 linear feet of paved road and adjacent right-of-way, referred to as ED-9C (0.98 acres). Transfer of the title to ED-9 will be by deed under a Covenant Deferral Request (CDR) pursuant to Section 120(h)(3)(C) of the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA). This report provides a summary of information to support the transfer of this government-owned property at ETTP to a non-federal entity.

  20. Genotype variant associated with add-on memantine in bipolar II disorder.

    PubMed

    Lee, Sheng-Yu; Chen, Shiou-Lan; Chang, Yun-Hsuan; Chen, Shih-Heng; Chu, Chun-Hsieh; Huang, San-Yuan; Tzeng, Nian-Sheng; Wang, Chen-Lin; Wang, Liang-Jen; Lee, I Hui; Yeh, Tzung Lieh; Yang, Yen Kuang; Hong, Jau-Shyong; Lu, Ru-Band

    2014-02-01

    Memantine is a non-competitive N-methyl-d-asparate (NMDA) receptor antagonist with a mood-stabilizing effect. We investigated whether using valproic acid (VPA) plus add-on memantine to treat bipolar II disorder (BP-II) is more effective than using VPA alone (VPA + Pbo). We also evaluated, in BP-II patients, the association between the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism with treatment response to VPA + add-on memantine and to VPA + Pbo. In this randomized, double-blind, controlled 12 wk study, BP-II patients undergoing regular VPA treatments were randomly assigned to a group: VPA + Memantine (5 mg/day) (n = 115) or VPA + Pbo (n = 117). The Hamilton Depression Rating Scale (HDRS) and Young Mania Rating Scale (YMRS) were used to evaluate clinical response during week 0, 1, 2, 4, 8 and 12. The genotypes of the BDNF Val66Met polymorphisms were determined using polymerase chain reactions plus restriction fragment length polymorphism analysis. To adjust within-subject dependence over repeated assessments, multiple linear regression with generalized estimating equation methods was used to analyze the effects of the BDNF Val66Met polymorphism on the clinical performance of memantine. Both groups showed significantly decreased YMRS and HDRS scores after 12 wk of treatment; the differences between groups were non-significant. When stratified by the BDNF Val66Met genotypes, significantly greater decreases in HDRS scores were found in the VPA + memantine group in patients with the Val Met genotype (p = 0.004). We conclude that the BDNF Val66Met polymorphism influenced responses to add-on memantine by decreasing depressive symptoms in patients with BP-II.

  1. What’s next after metformin? focus on sulphonylurea: add-on or combination therapy

    PubMed Central

    Lim, Phei C.; Chong, Chee P.

    2015-01-01

    Introduction: The pathophysiology of type 2 diabetes (T2DM) mainly focused on insulin resistance and insulin deficiency over the past decades. Currently, the pathophysiologies expanded to ominous octet and guidelines were updated with newer generation of antidiabetic drug classes. However, many patients had yet to achieve their target glycaemic control. Although all the guidelines suggested metformin as first line, there was no definite consensus on the second line drug agents as variety of drug classes were recommended. Objectives: The aim of this review was to evaluate the drug class after metformin especially sulphonylurea and issues around add-on or fixed dose combination therapy. Methods: Extensive literature search for English language articles, clinical practice guidelines and references was performed using electronic databases. Results: Adding sulphonylurea to metformin targeted both insulin resistance and insulin deficiency. Sulphonylurea was efficacious and cheaper than thiazolidinedione, dipeptidyl peptidase-4 inhibitor, glucagon-like peptide 1 analogue and insulin. The main side effect of sulphonylurea was hypoglycaemia but there was no effect on the body weight when combining with metformin. Fixed dose sulphonylurea/metformin was more efficacious at lower dose and reported to have fewer side effects with better adherence. Furthermore, fixed dose combination was cheaper than add-on therapy. In conclusion, sulphonylurea was feasible as the second line agent after metformin as the combination targeted on two pathways, efficacious, cost-effective and had long safety history. Fixed dose combination tablet could improve patient’s adherence and offered an inexpensive and more efficacious option regardless of original or generic product as compared to add-on therapy. PMID:26445623

  2. Reconfigurable optical add-drop multiplexer based on thermally tunable micro-ring resonators

    NASA Astrophysics Data System (ADS)

    Wu, Danning; Wu, Yuanda; Wang, Yue; An, Junming; Hu, Xiongwei

    2016-05-01

    We report on an eight-channel reconfigurable optical add-drop multiplexer (ROADM) based on micro-ring resonators (MRRs). The effective footprint of the device is about 1000×760 μm2. The free spectral range (FSR) is about 18 nm. The adjacent channel crosstalk ranges from -19.02 dB to -8.29 dB. With the help of the multi-wire structure heaters, compact footprint and high tuning efficiency are achieved simultaneously. Therefore, the minimum average tuning efficiency is 2.723 mW/nm.

  3. Remote PCF-based sensors multiplexing by using optical add-drop multiplexers

    NASA Astrophysics Data System (ADS)

    Bravo, Mikel; Candiani, Alessandro; Cucinotta, Annamaria; Selleri, Stefano; Lopez-Amo, Manuel; Kobelke, Jens; Schuster, Kay

    2014-04-01

    A 100 km remote PCF micro-displacement sensor multiplexing system based on optical add-drop multiplexers (OADMs) has been experimentally demonstrated. The PCF sensors are placed in an OADM bus structure which is illuminated by a home-made tunable fiber optic ring laser. Four micro-displacement photonic crystal fiber (PCF) sensors based on a suspended core fiber inserted into a Sagnac loop filter are multiplexed. Furthermore, being the first proposal to solve this issue in PCF sensor multiplexing structures, these sensors can be referenced with an extra wavelength.

  4. Sensitivity analysis of the add-on price estimate for the silicon web growth process

    NASA Technical Reports Server (NTRS)

    Mokashi, A. R.

    1981-01-01

    The web growth process, a silicon-sheet technology option, developed for the flat plate solar array (FSA) project, was examined. Base case data for the technical and cost parameters for the technical and commercial readiness phase of the FSA project are projected. The process add on price, using the base case data for cost parameters such as equipment, space, direct labor, materials and utilities, and the production parameters such as growth rate and run length, using a computer program developed specifically to do the sensitivity analysis with improved price estimation are analyzed. Silicon price, sheet thickness and cell efficiency are also discussed.

  5. Frequency-Domain Chromatic Dispersion Equalization Using Overlap-Add Methods in Coherent Optical System

    NASA Astrophysics Data System (ADS)

    Xu, T.; Jacobsen, G.; Popov, S.; Forzati, M.; Mårtensson, J.; Mussolin, M.; Li, J.; Wang, K.; Zhang, Y.; Friberg, A. T.

    2011-06-01

    The frequency domain equalizers (FDEs) employing two types of overlap-add zero-padding (OLA-ZP) methods are applied to compensate the chromatic dispersion in a 112-Gbit/s non-return-to-zero polarization division multiplexed quadrature phase shift keying (NRZ-PDM-QPSK) coherent optical transmission system. Simulation results demonstrate that the OLA-ZP methods can achieve the same acceptable performance as the overlapsave method. The required minimum overlap (or zero-padding) in the FDE is derived, and the optimum fast Fourier transform length to minimize the computational complexity is also analyzed.

  6. Can metabolomics in addition to genomics add to prognostic and predictive information in breast cancer?

    PubMed

    Howell, Anthony

    2010-11-16

    Genomic data from breast cancers provide additional prognostic and predictive information that is beginning to be used for patient management. The question arises whether additional information derived from other 'omic' approaches such as metabolomics can provide additional information. In an article published this month in BMC Cancer, Borgan et al. add metabolomic information to genomic measures in breast tumours and demonstrate, for the first time, that it may be possible to further define subgroups of patients which could be of value clinically. See research article: http://www.biomedcentral.com/1471-2407/10/628.

  7. Add-drop filters based on asymmetric high-order microring resonators

    NASA Astrophysics Data System (ADS)

    Zhang, Dong; Huang, Yongqing; Ren, Xiaomin; Duan, Xiaofeng; Shen, Bing; Wang, Qi; Zhang, Xia; Cai, Shiwei

    2012-11-01

    Add/drop filters are key components of Wavelength Division Multiplexing (WDM) communication systems. Free spectral range(FSR) is a key parameter for Add/drop filters, the FSR should operate within the entire C-band (1530-1562nm).And flat-top drop-port response with a sharp rolloff is also import, Flatness of the passband, sharp roll-off from passband to stop band are necessary to minimize the pulse broadening and the packing efficiency of wavelength channels. In this paper, we proposed an asymmetric approach to design high-order microring filters, The aim is to achieve large extension ratios and adequate suppression of the spurious interstitial mode, meanwhile, flat-top and steep-side response in filter could be obtained by this approach. Our simulation results showed an extended FSR of 40nm, reducing the interstitial peak suppression from 5dB to 35dB and a boxlike filter response with sharpe factor(SF) of 0.68. And a quality-factor of 2961 and a 3-dB bandwidth of 0.52nm is achieved.

  8. Full-optical tunable add/drop filter based on nonlinear photonic crystal ring resonators

    NASA Astrophysics Data System (ADS)

    Mansouri-Birjandi, Mohammad Ali; Tavousi, Alireza; Ghadrdan, Majid

    2016-09-01

    Here, we propose a full-optical tunable Add/Drop filter based on single (SR) and double-vertically (DR) aligned Kerr-like nonlinear photonic crystal ring resonators (PCRRs). Silicon (Si) nano-crystal is used as the nonlinear material inside and outside of PCRRs. The minimum optical power required to turn-on/turn-off the SR and DR filters are 2000 mW/μm2, and 150 mW/μm2, respectively. We believe since the DR filter has a higher Q-factor rather than SR and also since the optical power reads more nonlinear rods with a longer time to pass the structure, thus the optical power required is much lower (10 folds). In addition, the minimum power required to 1 nm redshift the center operating wavelength of SR filter is 125 mW/μm2 (i.e. ΔnNL = 0.005) and for DR is as low as 8 mW/μm2. Performance of the Add/Drop filter structure is simulated by means of finite difference time domain (FDTD) method, in which the simulations showed an ultra-compact size structure with promising ultrafast tune-ability speeds.

  9. Gantry and isocenter displacements of a linear accelerator caused by an add-on micromultileaf collimator

    SciTech Connect

    Riis, Hans L.; Zimmermann, Sune J.; Hjelm-Hansen, Mogens

    2013-03-15

    Purpose: The delivery of high quality stereotactic radiosurgery (SRS) and stereotactic radiotherapy (SRT) treatments to the patient requires knowledge of the position of the isocenter to submillimeter accuracy. To meet the requirements the deviation between the radiation and mechanical isocenters must be less than 1 mm. The use of add-on micromultileaf collimators ({mu}MLCs) in SRS and SRT is an additional challenge to the anticipated high-level geometric and dosimetric accuracy of the treatment. The aim of this work was to quantify the gantry excursions during rotation with and without an add-on {mu}MLC attached to the gantry head. In addition, the shift in the position of the isocenter and its correlation to the kV beam center of the cone-beam CT system was included in the study. Methods: The quantification of the gantry rotational performance was done using a pointer supported by an in-house made rigid holder attached to the gantry head of the accelerator. The pointer positions were measured using a digital theodolite. To quantify the effect of an {mu}MLC of 50 kg, the measurements were repeated with the {mu}MLC attached to the gantry head. The displacement of the isocenter due to an add-on {mu}MLC of 50 kg was also investigated. In case of the pointer measurement the {mu}MLC was simulated by weights attached to the gantry head. A method of least squares was applied to determine the position and displacement of the mechanical isocenter. Additionally, the displacement of the radiation isocenter was measured using a ball-bearing phantom and the electronic portal image device system. These measurements were based on 8 MV photon beams irradiated onto the ball from the four cardinal angles and two opposed collimator angles. The measurements and analysis of the data were carried out automatically using software delivered by the manufacturer. Results: The displacement of the mechanical isocenter caused by a 50 kg heavy {mu}MLC was found to be (-0.01 {+-} 0.05, -0

  10. 76 FR 37115 - Determination Concerning a Petition To Add a Class of Employees to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-24

    ... to add a class of employees from the Wah Chang facility in Albany, Oregon, to the Special Exposure... Atomic Weapons Employees who worked in any building at the Wah Chang facility in Albany, Oregon, for...

  11. [Should we add antiplatelet therapy to oral anticoagulation in patients with atrial fibrillation and vascular disease? Review of available evidence].

    PubMed

    Andreu, José Manuel; Roldán, Vanessa; García-Navarro, Miguel; Ruipérez, Juan Antonio; Valdés, Mariano; Marín, Francisco

    2012-01-01

    Current recommendation is to add antiplatelet drug to oral anticoagulation in patients with atrial fibrillation (AF) and vascular disease. However, it is debatable to join both antithrombotic drugs in stable vascular disease.

  12. 76 FR 37114 - Determination Concerning a Petition To Add a Class of Employees to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-24

    ... to add a class of employees from the Linde Ceramics Plant in Tonawanda, New York, to the Special... Department of Energy employees and Atomic Weapons Employees who worked at the Linde Ceramics Plant...

  13. 76 FR 37115 - Determination Concerning a Petition To Add a Class of Employees to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-24

    ... to add a class of employees from the Chapman Valve Manufacturing Company (i.e., Building 23 and Dean... Commission work at the Chapman Valve Manufacturing Company (i.e., Building 23 and Dean Street facility)...

  14. 77 FR 32642 - Determination Concerning a Petition To Add a Class of Employees to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-01

    ... notice of a determination concerning a petition to add a class of employees from Hangar 481 at Kirtland... authorized under EEOICPA: All employees who worked at Hangar 481, Kirtland Air Force Base, from March 1,...

  15. 78 FR 18351 - Determination Concerning a Petition To Add a Class of Employees to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-26

    ... notice of a determination concerning a petition to add a class of employees from General Steel Industries... Steel Industries site, located at 1417 State Street, Granite City, Illinois, from January 1,...

  16. 78 FR 38265 - Wireline Competition Bureau Adds Two New Discussion Topics to Connect America Cost Model Virtual...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-26

    ... Model Virtual Workshop AGENCY: Federal Communications Commission. ACTION: Proposed rule. SUMMARY: In this document, the Wireline Competition Bureau adds two new virtual workshop discussion topics.../ecfs2/ . Follow the instructions for submitting comments. Virtual Workshop: In addition to the...

  17. 78 FR 23192 - Wireline Competition Bureau Adds New Discussion Topic to Connect America Cost Model Virtual Workshop

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-18

    ... Virtual Workshop AGENCY: Federal Communications Commission. ACTION: Proposed rule. SUMMARY: In this document, the Wireline Competition Bureau adds a new virtual workshop discussion topic, entitled... for submitting comments. Virtual Workshop: In addition to the usual methods for filing...

  18. Covenant Deferral Request for the Proposed Transfer of Land Parcel ED-8 at the East Tennessee Technology Park, Oak Ridge, Tennessee - Final - May 2009

    SciTech Connect

    SAIC

    2009-05-01

    The United States Department of Energy (DOE) is proposing to transfer a land parcel (hereinafter referred to as 'the Property') designated as Land Parcel ED-8 at the East Tennessee Technology Park (ETTP) in Oak Ridge, Tennessee, by deed, and is submitting this Covenant Deferral Request (CDR) pursuant to Section 120(h)(3)(C) of the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA), as amended, and applicable U. S. Environmental Protection Agency (EPA) guidance. The Oak Ridge Reservation (ORR), which includes ETTP, was placed on the National Priorities List (NPL) in November 1989. Environmental investigation and cleanup activities are continuing at ETTP in accordance with CERCLA, the National Contingency Plan (NCP), and the Federal Facility Agreement (FFA). The FFA was entered into by the DOE-Oak Ridge Office (ORO), EPA Region 4, and the Tennessee Department of Environment and Conservation (TDEC) in 1991. The FFA establishes the schedule and milestones for environmental remediation of the ORR. The proposed property transfer is a key component of the Oak Ridge Performance Management Plan (ORPMP) for accelerated cleanup of the ORR. DOE, using its authority under Section 161(g) of the Atomic Energy Act of 1954 (AEA), proposes to transfer the Property to Heritage Center, LLC, a subsidiary of the Community Reuse Organization of East Tennessee (CROET), hereafter referred to as 'Heritage Center.' CROET is a 501(c)(3) not-for-profit corporation established to foster the diversification of the regional economy by re-utilizing DOE property for private-sector investment and job creation. The Property is located in the southern portion of ETTP and consists of approximately 84 acres proposed as the potential site for new facilities to be used for office space, industrial activities, or other commercial uses. The parcel contains both grassy fields located outside the ETTP 'main plant' area and infrastructure located inside the 'main plant' area. No

  19. Environmental baseline survey report for West Black Oak Ridge, East Black Oak Ridge, McKinney Ridge, West Pine Ridge and parcel 21D in the vicinity of the East Technology Park, Oak Ridge, Tennessee

    SciTech Connect

    King, David A.

    2012-11-29

    This environmental baseline survey (EBS) report documents the baseline environmental conditions of five land parcels located near the U.S. Department of Energy?s (DOE?s) East Tennessee Technology Park (ETTP), including West Black Oak Ridge, East Black Oak Ridge, McKinney Ridge, West Pine Ridge, and Parcel 21d. Preparation of this report included the detailed search of federal government records, title documents, aerial photos that may reflect prior uses, and visual inspections of the property and adjacent properties. Interviews with current employees involved in, or familiar with, operations on the real property were also conducted to identify any areas on the property where hazardous substances and petroleum products, or their derivatives, and acutely hazardous wastes may have been released or disposed. In addition, a search was made of reasonably obtainable federal, state, and local government records of each adjacent facility where there has been a release of any hazardous substance or any petroleum product or their derivatives, including aviation fuel and motor oil, and which is likely to cause or contribute to a release of any hazardous substance or any petroleum product or its derivatives, including aviation fuel or motor oil, on the real property. A radiological survey and soil/sediment sampling was conducted to assess baseline conditions of Parcel 21d that were not addressed by the soils-only no-further-investigation (NFI) reports. Groundwater sampling was also conducted to support a Parcel 21d decision. Based on available data West Black Oak Ridge, East Black Oak Ridge, McKinney Ridge, and West Pine Ridge are not impacted by site operations and are not subject to actions per the Federal Facility Agreement (FFA). This determination is supported by visual inspections, records searches and interviews, groundwater conceptual modeling, approved NFI reports, analytical data, and risk analysis results. Parcel 21d data, however, demonstrate impacts from site

  20. Hippocampal Volume Is Reduced in Schizophrenia and Schizoaffective Disorder But Not in Psychotic Bipolar I Disorder Demonstrated by Both Manual Tracing and Automated Parcellation (FreeSurfer)

    PubMed Central

    Arnold, Sara J. M.; Ivleva, Elena I.; Gopal, Tejas A.; Reddy, Anil P.; Jeon-Slaughter, Haekyung; Sacco, Carolyn B.; Francis, Alan N.; Tandon, Neeraj; Bidesi, Anup S.; Witte, Bradley; Poudyal, Gaurav; Pearlson, Godfrey D.; Sweeney, John A.; Clementz, Brett A.; Keshavan, Matcheri S.; Tamminga, Carol A.

    2015-01-01

    This study examined hippocampal volume as a putative biomarker for psychotic illness in the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) psychosis sample, contrasting manual tracing and semiautomated (FreeSurfer) region-of-interest outcomes. The study sample (n = 596) included probands with schizophrenia (SZ, n = 71), schizoaffective disorder (SAD, n = 70), and psychotic bipolar I disorder (BDP, n = 86); their first-degree relatives (SZ-Rel, n = 74; SAD-Rel, n = 62; BDP-Rel, n = 88); and healthy controls (HC, n = 145). Hippocampal volumes were derived from 3Tesla T1-weighted MPRAGE images using manual tracing/3DSlicer3.6.3 and semiautomated parcellation/FreeSurfer5.1,64bit. Volumetric outcomes from both methodologies were contrasted in HC and probands and relatives across the 3 diagnoses, using mixed-effect regression models (SAS9.3 Proc MIXED); Pearson correlations between manual tracing and FreeSurfer outcomes were computed. SZ (P = .0007–.02) and SAD (P = .003–.14) had lower hippocampal volumes compared with HC, whereas BDP showed normal volumes bilaterally (P = .18–.55). All relative groups had hippocampal volumes not different from controls (P = .12–.97) and higher than those observed in probands (P = .003–.09), except for FreeSurfer measures in bipolar probands vs relatives (P = .64–.99). Outcomes from manual tracing and FreeSurfer showed direct, moderate to strong, correlations (r = .51–.73, P < .05). These findings from a large psychosis sample support decreased hippocampal volume as a putative biomarker for schizophrenia and schizoaffective disorder, but not for psychotic bipolar I disorder, and may reflect a cumulative effect of divergent primary disease processes and/or lifetime medication use. Manual tracing and semiautomated parcellation regional volumetric approaches may provide useful outcomes for defining measurable biomarkers underlying severe mental illness. PMID:24557771

  1. Synchronous Changes of Cortical Thickness and Corresponding White Matter Microstructure During Brain Development Accessed by Diffusion MRI Tractography from Parcellated Cortex

    PubMed Central

    Jeon, Tina; Mishra, Virendra; Ouyang, Minhui; Chen, Min; Huang, Hao

    2015-01-01

    Cortical thickness (CT) changes during normal brain development is associated with complicated cellular and molecular processes including synaptic pruning and apoptosis. In parallel, the microstructural enhancement of developmental white matter (WM) axons with their neuronal bodies in the cerebral cortex has been widely reported with measurements of metrics derived from diffusion tensor imaging (DTI), especially fractional anisotropy (FA). We hypothesized that the changes of CT and microstructural enhancement of corresponding axons are highly interacted during development. DTI and T1-weighted images of 50 healthy children and adolescents between the ages of 7 and 25 years were acquired. With the parcellated cortical gyri transformed from T1-weighted images to DTI space as the tractography seeds, probabilistic tracking was performed to delineate the WM fibers traced from specific parcellated cortical regions. CT was measured at certain cortical regions and FA was measured from the WM fibers traced from same cortical regions. The CT of all frontal cortical gyri, including Brodmann areas 4, 6, 8, 9, 10, 11, 44, 45, 46, and 47, decreased significantly and heterogeneously; concurrently, significant, and heterogeneous increases of FA of WM traced from corresponding regions were found. We further revealed significant correlation between the slopes of the CT decrease and the slopes of corresponding WM FA increase in all frontal cortical gyri, suggesting coherent cortical pruning and corresponding WM microstructural enhancement. Such correlation was not found in cortical regions other than frontal cortex. The molecular and cellular mechanisms of these synchronous changes may be associated with overlapping signaling pathways of axonal guidance, synaptic pruning, neuronal apoptosis, and more prevalent interstitial neurons in the prefrontal cortex. Revealing the coherence of cortical and WM structural changes during development may open a new window for understanding the

  2. SAPling: a Scan-Add-Print barcoding database system to label and track asexual organisms

    PubMed Central

    Thomas, Michael A.; Schötz, Eva-Maria

    2011-01-01

    SUMMARY We have developed a ‘Scan-Add-Print’ database system, SAPling, to track and monitor asexually reproducing organisms. Using barcodes to uniquely identify each animal, we can record information on the life of the individual in a computerized database containing its entire family tree. SAPling has enabled us to carry out large-scale population dynamics experiments with thousands of planarians and keep track of each individual. The database stores information such as family connections, birth date, division date and generation. We show that SAPling can be easily adapted to other asexually reproducing organisms and has a strong potential for use in large-scale and/or long-term population and senescence studies as well as studies of clonal diversity. The software is platform-independent, designed for reliability and ease of use, and provided open source from our webpage to allow project-specific customization. PMID:21993779

  3. Add-on simple adaptive control improves performance of classical control design

    NASA Astrophysics Data System (ADS)

    Weiss, Haim; Rusnak, Ilan

    2014-12-01

    The Simple Adaptive Control (SAC) controls an augmented plant that comprises the true plant with parallel feed-forward. The Almost Strictly Positive Real (ASPR) property of the augmented plant leads to asymptotic following. Prior publications have shown that, based only on the prior knowledge on stabilizability properties of systems (usually available), the parallel feed-forward configuration (PFC) allows adaptive control of realistic systems, even if they are both unstable and non-minimum phase. However, it was commonly thought that the PFC addition requires a price when compared with good linear time invariant (LTI) designs that do not use any addition to the plant. The paper shows that the use of SAC with PFC as Add-On to LTI system design improves the performance. Although SAC directly controls the augmented error, it always gives improved performance, i.e., smaller tracking error and reduced sensitivity to plant disturbance, with respect to the best LTI controller.

  4. Celecoxib Adjunctive Treatment to Antipsychotics in Schizophrenia: A Review of Randomized Clinical Add-On Trials.

    PubMed

    Marini, Stefano; De Berardis, Domenico; Vellante, Federica; Santacroce, Rita; Orsolini, Laura; Valchera, Alessandro; Girinelli, Gabriella; Carano, Alessandro; Fornaro, Michele; Gambi, Francesco; Martinotti, Giovanni; Di Giannantonio, Massimo

    2016-01-01

    Schizophrenia is a severe, chronic and debilitating mental disorder. Past literature has reported various hypotheses about the psychopathology of schizophrenia. Recently, a growing literature has been trying to explain the role of inflammation in the etiopathogenesis of schizophrenia. In the past, numerous immune modulation and anti-inflammatory treatment options have been proposed for schizophrenia, but sometimes the results were inconsistent. Electronic search was carried out in November 2015. PubMed and Scopus databases have been used to find studies to introduce in this review. Only randomized-placebo-controlled add-on trials were taken into account. In this way, six articles were obtained for the discussion. Celecoxib showed beneficial effects mostly in early stages of schizophrenia. In chronic schizophrenia, the data are controversial, possibly in part for methodological reasons. PMID:27524864

  5. Passive neutron assay of heterogeneous waste drums using the segmented Add-a-Source method

    SciTech Connect

    Menlove, H.O.

    1995-07-01

    We have developed passive neutron detectors that include the Add-a-Source (AS) technique to improve the accuracy of the nondestructive assay of plutonium in large waste containers. We have improved the AS by incorporating multiple positions for the {sup 252}Cf source on the exterior of a 200-L drum. The multiple positions give a better coverage of the drum and have the effect of segmenting the matrix as a function of fill height. We have applied the multiposition AS to the assay of drums with heterogeneous matrix combinations of concrete, polyethylene, wood, paper, and metal. The measurement errors caused by the matrix significantly reduced by the AS technique and anomalous shielding material in the drum can be flagged for more detailed investigation.

  6. Design of a reconfigurable optical add/drop multiplexer based on tunable Fabry-Perot array

    NASA Astrophysics Data System (ADS)

    Ye, Jiansen; Wang, Xin; Li, Zhuo; Yang, Yang; Xu, Rui; Shi, Rui

    2015-08-01

    With the development of optical fiber communication, dense wavelength division multiplexing (DWDM) system is important for the rapid management of multi-wavelength in the core node of the optical transmission network. In this paper, a reconfigurable optical add-drop multiplexer (ROADM) based on the tunable Fabry-Perot (F-P) array is proposed. An optical switch with high isolation and low crosstalk is designed by using the characteristics of filtering and tuning for the F-P array. The principle, structure, and function of the tunable F-P array are introduced. The characteristics of filtering and tuning for the F-P filter are also calculated, and the factor for the isolation, crosstalk, response time and insertion loss are analyzed. A single physical channel ROADM with 16 signal channels, which operates in C-band, is designed and optimized by simulation.

  7. Nanophotonic graphene-based racetrack-resonator add/drop filter

    NASA Astrophysics Data System (ADS)

    Wirth L., A.; da Silva, M. G.; Neves, D. M. C.; Sombra, A. S. B.

    2016-05-01

    We are presenting and analyzing a graphene-based nanophotonic device to operate as a resonator-add/drop filter, whose control is obtained by varying the graphene chemical potential. That device consists of graphene-based waveguides, two directional couplers and a racetrack resonator with 90° bends. Since the graphene chemical potential provides the achievement of the necessary parameters, the resonance and filtering of the signals are obtained by applying the correct value of the graphene chemical potential in the graphene nanoribbons. The results of this study should help in the development of new graphene-based nanophotonic devices operating in the terahertz and infrared range (including in the C-band of the International Telecommunication Union - ITU), for use in future communications networks.

  8. Sliding tethered ligands add topological interactions to the toolbox of ligand-receptor design

    NASA Astrophysics Data System (ADS)

    Bauer, Martin; Kékicheff, Patrick; Iss, Jean; Fajolles, Christophe; Charitat, Thierry; Daillant, Jean; Marques, Carlos M.

    2015-09-01

    Adhesion in the biological realm is mediated by specific lock-and-key interactions between ligand-receptor pairs. These complementary moieties are ubiquitously anchored to substrates by tethers that control the interaction range and the mobility of the ligands and receptors, thus tuning the kinetics and strength of the binding events. Here we add sliding anchoring to the toolbox of ligand-receptor design by developing a family of tethered ligands for which the spacer can slide at the anchoring point. Our results show that this additional sliding degree of freedom changes the nature of the adhesive contact by extending the spatial range over which binding may sustain a significant force. By introducing sliding tethered ligands with self-regulating length, this work paves the way for the development of versatile and reusable bio-adhesive substrates with potential applications for drug delivery and tissue engineering.

  9. Benefits and risks of add-on therapies for Alzheimer's disease.

    PubMed

    Magierski, Radoslaw; Sobow, Tomasz

    2015-10-01

    Despite three decades of intensive research, the efforts of scientific society and industry and the expenditures, numerous attempts to develop effective treatments for Alzheimer's disease have failed. Currently, approved and widely used medications to treat cognitive deficits in Alzheimer's disease are symptomatic only and show at best modest efficacy. In this context, the need to develop a successful, disease-modifying treatment is loudly expressed. One way to achieve this goal is the use of add-on therapies or various combinations of existing 'conventional' drugs. Results of several clinical studies and post hoc analyses of combination therapy with all cholinesterase inhibitors and memantine are published. Moreover, there is a need for studies on long-term efficacy of combination therapy in Alzheimer's.

  10. Celecoxib Adjunctive Treatment to Antipsychotics in Schizophrenia: A Review of Randomized Clinical Add-On Trials

    PubMed Central

    De Berardis, Domenico; Vellante, Federica; Santacroce, Rita; Orsolini, Laura; Valchera, Alessandro; Girinelli, Gabriella; Carano, Alessandro; Fornaro, Michele; Gambi, Francesco; Martinotti, Giovanni; Di Giannantonio, Massimo

    2016-01-01

    Schizophrenia is a severe, chronic and debilitating mental disorder. Past literature has reported various hypotheses about the psychopathology of schizophrenia. Recently, a growing literature has been trying to explain the role of inflammation in the etiopathogenesis of schizophrenia. In the past, numerous immune modulation and anti-inflammatory treatment options have been proposed for schizophrenia, but sometimes the results were inconsistent. Electronic search was carried out in November 2015. PubMed and Scopus databases have been used to find studies to introduce in this review. Only randomized-placebo-controlled add-on trials were taken into account. In this way, six articles were obtained for the discussion. Celecoxib showed beneficial effects mostly in early stages of schizophrenia. In chronic schizophrenia, the data are controversial, possibly in part for methodological reasons. PMID:27524864

  11. Wavelength tunable integrated add-drop filter with 10.6 nm bandwidth adjustability.

    PubMed

    Boroojerdi, M T; Ménard, M; Kirk, A G

    2016-09-19

    We present the design and characterization of a silicon-on-insulator based bandwidth and wavelength-tunable add-drop filter. The tunability of the device is achieved by independently controlling the central wavelength of two cascaded contra-directional grating assisted couplers. The device was fabricated using e-beam lithography and the tuning is demonstrated using the thermo-optic effect, which was obtained with metal heaters fabricated by a lift-off process. It is experimentally demonstrated that within the wavelength range of 1555 nm to 1573 nm the transmission bandwidth of the device can be tuned from 1.1 nm to 11.7 nm. Moreover, more than 4 nm of central wavelength tuning is demonstrated. The tunability of the central wavelength is limited by the breakdown current of the metal heaters. PMID:27661939

  12. Addiction surplus: the add-on margin that makes addictive consumptions difficult to contain.

    PubMed

    Adams, Peter J; Livingstone, Charles

    2015-01-01

    Addictive consumptions generate financial surpluses over-and-above non-addictive consumptions because of the excessive consumption of addicted consumers. This add-on margin or 'addiction surplus' provides a powerful incentive for beneficiaries to protect their income by ensuring addicted consumers keep consuming. Not only that, addiction surplus provides the financial base that enables producers to sponsor activities which aim to prevent public health initiatives from reducing consumption. This paper examines the potency of addiction surplus to engage industry, governments and communities in an on-going reliance on addiction surplus. It then explores how neo-liberal constructions of a rational consumer disguise the ethical and exploitative dynamics of addiction surplus by examining ways in which addictive consumptions fail to conform to notions of autonomy and rationality. Four measures are identified to contain the distorting effects of addiction surplus.

  13. SCEW: a Microsoft Excel add-in for easy creation of survival curves.

    PubMed

    Khan, Haseeb Ahmad

    2006-07-01

    Survival curves are frequently used for reporting survival or mortality outcomes of experimental pharmacological/toxicological studies and of clinical trials. Microsoft Excel is a simple and widely used tool for creation of numerous types of graphic presentations however it is difficult to create step-wise survival curves in Excel. Considering the familiarity of clinicians and biomedical scientists with Excel, an algorithm survival curves in Excel worksheet (SCEW) has been developed for easy creation of survival curves directly in Excel worksheets. The algorithm has been integrated in the form of Excel add-in for easy installation and usage. The program is based on modification of frequency data for binary break-up using the spreadsheet formula functions whereas a macro subroutine automates the creation of survival curves. The advantages of this program are simple data input, minimal procedural steps and the creation of survival curves in the familiar confines of Excel.

  14. Sliding tethered ligands add topological interactions to the toolbox of ligand–receptor design

    PubMed Central

    Bauer, Martin; Kékicheff, Patrick; Iss, Jean; Fajolles, Christophe; Charitat, Thierry; Daillant, Jean; Marques, Carlos M.

    2015-01-01

    Adhesion in the biological realm is mediated by specific lock-and-key interactions between ligand–receptor pairs. These complementary moieties are ubiquitously anchored to substrates by tethers that control the interaction range and the mobility of the ligands and receptors, thus tuning the kinetics and strength of the binding events. Here we add sliding anchoring to the toolbox of ligand–receptor design by developing a family of tethered ligands for which the spacer can slide at the anchoring point. Our results show that this additional sliding degree of freedom changes the nature of the adhesive contact by extending the spatial range over which binding may sustain a significant force. By introducing sliding tethered ligands with self-regulating length, this work paves the way for the development of versatile and reusable bio-adhesive substrates with potential applications for drug delivery and tissue engineering. PMID:26350224

  15. The CONVEX Liner Add-On to the DIAMOND-FORTUNE event

    SciTech Connect

    Heuze, F.E.; Swift, R.P.; Hill, L.R.; Barrett, W.H.

    1993-11-15

    This report describes the execution of the CONVEX Liner Add-On to the DIAMOND FORTUNE low-yield cavity test of the Defense Nuclear Agency. CONVEX stands for COntained Nuclear Vessel EXperiment. It concerns the design of underground chambers where repeated low-yield nuclear explosions could be conducted. The approach proposed by the first author in the early 1980`s was to engineer a steel-lined rock cavern where the steel liner would be prestressed against the rock by tendons and/or bolts. These would daylight in tunnels surrounding the main cavity. From there, they could be initially tensioned and retensioned, if needed, after each test. The CONVEX Liner Add-On to DIAMOND FORTUNE consisted of anchoring a 1.4-m square, 2.5-cm thick steel plate to the wall of the cavity, using a 5-cm diameter center bolt, and four 2.5-cm diameter comer bolts. The bolts daylighted in a drift surrounding the gallery, and separated from it by a 9-m thick rock pillar. The liner plate, the bolts, and the rock pillar were equipped with 23 gages to describe the thermal and mechanical response of the system during pretensioning, during the dynamic loading phase, and post-test. Particular emphasis was given to obtaining the response both upon loading and during the rebound of the system, in order to determine whether the plate ever separated from the rock. So, the main operational objectives of this project were to acquire response data of the system under nuclear loading and to ascertain the status of contact between the steel plate and the rock, as shown by toadstool data and bolt tension data. The instrumentation and data acquisition system performed extremely well. Data were recorded during the dynamic phase; plate temperature was monitored for several hours after the test; and the remaining tension was obtained for several bolts more than three months after the test, upon re-entry in the runaround drift.

  16. Add Java extensions to your wiki: Java applets can bring dynamic functionality to your wiki pages

    SciTech Connect

    Scarberry, Randall E.

    2008-08-12

    Virtually everyone familiar with today’s world wide web has encountered the free online encyclopedia Wikipedia many times. What you may not know is that Wikipedia is driven by an excellent open-source product called MediaWiki which is available to anyone for free. This has led to a proliferation of wiki sites devoted to just about any topic one can imagine. Users of a wiki can add content -- all that is required of them is that they type in their additions into their web browsers using the simple markup language called wikitext. Even better, the developers of wikitext made it extensible. With a little server-side development of your own, you can add your own custom syntax. Users aware of your extensions can then utilize them on their wiki pages with a few simple keystrokes. These extensions can be custom decorations, formatting, web applications, and even instances of the venerable old Java applet. One example of a Java applet extension is the Jmol extension (REF), used to embed a 3-D molecular viewer. This article will walk you through the deployment of a fairly elaborate applet via a MediaWiki extension. By no means exhaustive -- an entire book would be required for that -- it will demonstrate how to give the applet resize handles using using a little Javascript and CSS coding and some popular Javascript libraries. It even describes how a user may customize the extension somewhat using a wiki template. Finally, it explains a rudimentary persistence mechanism which allows applets to save data directly to the wiki pages on which they reside.

  17. Caloric beverages consumed freely at meal-time add calories to an ad libitum meal.

    PubMed

    Panahi, Shirin; El Khoury, Dalia; Luhovyy, Bohdan L; Goff, H Douglas; Anderson, G Harvey

    2013-06-01

    The objective was to compare the effects of ad libitum consumption of commonly consumed meal-time beverages on energy and fluid intakes and post-meal average subjective appetite and blood glucose in healthy adults. In a randomized controlled design, 29 males and females consumed to satiation an ad libitum pizza meal with one of five beverages in unlimited amount including water (0 kcal), 1% milk (44 kcal/100 ml), regular cola (44 kcal/100 ml), orange juice (44 kcal/100 ml) and diet cola (0 kcal). Food and fluid intakes were measured at the meal. Average subjective appetite and blood glucose were measured before and for 2h after the meal. Although energy intake from pizza was similar among all beverage treatments, the amount of fluid consumed (g) varied among the beverages with intake of orange juice higher than regular and diet cola, but not different from water or milk. Meal-time ingestion of caloric beverages, milk, orange juice and regular cola, led to higher total meal-time energy intakes compared to either water or diet cola. Post-meal blood glucose area under the curve (AUC) was lower after milk than after meals with water, orange juice and regular cola and post-meal average subjective appetite AUC was lower after milk than after meals with water. Meal intakes of nutrients including protein, calcium, phosphorus, zinc, vitamins B12, A and D were higher at the meal with milk compared to the other beverages. Thus, caloric beverages consumed ad libitum during a meal add to total meal-time energy intake, but 1% milk favors a lower post-meal blood glucose and average subjective appetite score and adds to nutrient intake.

  18. A study of high repetition rate pulse generation and all-optical add/drop multiplexing

    NASA Astrophysics Data System (ADS)

    Chen, Hongmin

    Ultra high-speed optical time-division-multiplexed (OTDM) transmission technologies are essential for the construction of ultra high-speed all-optical networks needed in the information era. In this Ph. D thesis dissertation, essential mechanisms associated with ultra high speed OTDM transmission systems, such as, high speed ultra short pulse generation, all optical demultiplexing and all optical add/drop multiplexing, have been studied. Both experimental demonstrations and numerical simulations have been performed. In order to realize high-speed optical TDM systems, high repetition rate, ultra short pulses are needed. A rational harmonic mode-locked ring fiber laser has been used to produce ultrashort pulses, the pulse jitter will be eliminated using a Phase-Locked-Loop (PLL), and the self-pulsation has been suppressed using a semiconductor optical amplifier (SOA). Sub pico-second pulses are very important for all optical sampling in the ultrahigh-speed OTDM transmission system. In this thesis, a two stage compression scheme utilizing the nonlinearity and dispersion of the optical fibers has been constructed and used to compress the gain switched DFB laser pulses. Also a nonlinear optical loop mirror has been constructed to suppress the wings associated with nonlinear compression. Pedestal free, transform-limited pulses with pulse widths in range of 0.2 to 0.4 ps have been generated. LiNbO3 modulators play a very important role in fiber optical communication systems. In this thesis, LiNbO3 modulators have been used to perform high repetition rate pulse generation, all optical demultiplexing and all optical add/drop for the TDM transmission system.

  19. 40 CFR 63.3174 - What are the requirements for a capture system or add-on control device which is not taken into...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... system or add-on control device which is not taken into account when demonstrating compliance with the... Electrodeposition Primer Emission Limitations § 63.3174 What are the requirements for a capture system or add-on... limitations? You may have capture systems or add-on control devices which you choose not to take into...

  20. 40 CFR 63.4363 - How do I establish the add-on control device operating limits during the performance test?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 12 2011-07-01 2009-07-01 true How do I establish the add-on control... § 63.4363 How do I establish the add-on control device operating limits during the performance test... specified in § 63.4292. (a) Thermal oxidizers. If your add-on control device is a thermal...

  1. 40 CFR 63.3174 - What are the requirements for a capture system or add-on control device which is not taken into...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... system or add-on control device which is not taken into account when demonstrating compliance with the... Electrodeposition Primer Emission Limitations § 63.3174 What are the requirements for a capture system or add-on... limitations? You may have capture systems or add-on control devices which you choose not to take into...

  2. 40 CFR 63.4767 - How do I establish the emission capture system and add-on control device operating limits during...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 12 2011-07-01 2009-07-01 true How do I establish the emission capture... Rate with Add-on Controls Option § 63.4767 How do I establish the emission capture system and add-on...) Carbon adsorbers. If your add-on control device is a carbon adsorber, establish the operating...

  3. 40 CFR 63.4966 - How do I establish the emission capture system and add-on control device operating limits during...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 12 2011-07-01 2009-07-01 true How do I establish the emission capture... with Add-on Controls Option § 63.4966 How do I establish the emission capture system and add-on control... to § 63.4965. (c) Carbon adsorbers. If your add-on control device is a carbon adsorber, establish...

  4. 40 CFR 63.3546 - How do I establish the emission capture system and add-on control device operating limits during...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 13 2013-07-01 2012-07-01 true How do I establish the emission capture... Emission Rate with Add-on Controls Option § 63.3546 How do I establish the emission capture system and add... the emission stream for leakage. (d) Carbon adsorbers. If your add-on control device is a...

  5. 40 CFR 63.4966 - How do I establish the emission capture system and add-on control device operating limits during...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 13 2013-07-01 2012-07-01 true How do I establish the emission capture... Emission Rate with Add-on Controls Option § 63.4966 How do I establish the emission capture system and add... to § 63.4965. (c) Carbon adsorbers. If your add-on control device is a carbon adsorber, establish...

  6. Field site selection

    NASA Technical Reports Server (NTRS)

    Schwarz, D. E.; Ellefsen, R. E.

    1981-01-01

    Several general guidelines should be kept in mind when considering the selection of field sites for teaching remote sensing fundamentals. Proximity and vantage point are two very practical considerations. Only through viewing a broad enough area to place the site in context can one make efficient use of a site. The effects of inclement weather when selecting sites should be considered. If field work is to be an effective tool to illustrate remote sensing principles, the following criteria are critical: (1) the site must represent the range of class interest; (2) the site must have a theme or add something no other site offers; (3) there should be intrasite variation within the theme; (4) ground resolution and spectral signature distinction should be illustrated; and (5) the sites should not be ordered sequentially.

  7. Chi hotspots trigger a conformational change in the helicase-like domain of AddAB to activate homologous recombination

    PubMed Central

    Gilhooly, Neville S.; Carrasco, Carolina; Gollnick, Benjamin; Wilkinson, Martin; Wigley, Dale B.; Moreno-Herrero, Fernando; Dillingham, Mark S.

    2016-01-01

    In bacteria, the repair of double-stranded DNA breaks is modulated by Chi sequences. These are recognised by helicase-nuclease complexes that process DNA ends for homologous recombination. Chi activates recombination by changing the biochemical properties of the helicase-nuclease, transforming it from a destructive exonuclease into a recombination-promoting repair enzyme. This transition is thought to be controlled by the Chi-dependent opening of a molecular latch, which enables part of the DNA substrate to evade degradation beyond Chi. Here, we show that disruption of the latch improves Chi recognition efficiency and stabilizes the interaction of AddAB with Chi, even in mutants that are impaired for Chi binding. Chi recognition elicits a structural change in AddAB that maps to a region of AddB which resembles a helicase domain, and which harbours both the Chi recognition locus and the latch. Mutation of the latch potentiates the change and moderately reduces the duration of a translocation pause at Chi. However, this mutant displays properties of Chi-modified AddAB even in the complete absence of bona fide hotspot sequences. The results are used to develop a model for AddAB regulation in which allosteric communication between Chi binding and latch opening ensures quality control during recombination hotspot recognition. PMID:26762979

  8. Add-on conservation benefits of marine territorial user rights fishery policies in central Chile.

    PubMed

    Gelcich, Stefan; Godoy, Natalio; Prado, Luis; Castilla, Juan Carlos

    2008-01-01

    To combine the rational use of marine benthic resources and economic development of small-scale fishers, Chile passed legislation in 1991 establishing a comanagement policy that grants exclusive territorial user rights for fisheries (TURFs) to artisanal fisher organizations in well-defined inshore coastal areas, known as Management and Exploitation Areas for Benthic Resources (MEABRs). In general the policy has been proclaimed a management and economic success because benthic resource abundances have increased inside MEABRs in comparison with open-access areas. However, there is a lack of studies assessing the impact of this management policy on nontargeted subtidal species and community assemblages and the policy's implications for biodiversity and conservation. This study starts to fill this gap and links the allocation of TURFs for benthic resources with add-on conservation benefits for species that are not directly linked with the fishery policy. Comparative subtidal surveys inside vs. outside MEABRs were used to assess the effects of three MEABRs on managed targeted benthic species, biodiversity (species richness), and community assemblages in central Chile. Surveys focused exclusively on subtidal kelp forest habitats dominated by Lessonia trabeculata, spanning 4-12 m in depth and with similar levels of habitat complexity. The study comprised: (1) quantification of kelp forest complexity, (2) understory survey of sessile species, (3) quantification of conspicuous benthic macroinvertebrates, including those under management, and (4) quantification of reef-fish species inside the kelp habitat. Results showed population enhancement of target-managed invertebrates inside MEABRs. Moreover, reef-fish species were significantly more diverse and abundant inside MEABRs, and community assemblages of nontarget benthic invertebrates and reef fish were significantly different inside vs. outside MEABRs. The comanagement of inshore benthic resources in Chile, through MEABRs

  9. Next-Generation AUC Adds a Spectral Dimension: Development of Multiwavelength Detectors for the Analytical Ultracentrifuge.

    PubMed

    Pearson, Joseph Z; Krause, Frank; Haffke, Dirk; Demeler, Borries; Schilling, Kristian; Cölfen, Helmut

    2015-01-01

    We describe important advances in analytical ultracentrifugation (AUC) hardware, which add new information to the hydrodynamic information observed in traditional AUC instruments. In contrast to the Beckman-Coulter XLA UV/visible detector, multiwavelength (MWL) detection is able to collect sedimentation data not just for one wavelength, but for a large wavelength range in a single experiment. The additional dimension increases the data density by orders of magnitude, significantly improving the statistics of the measurement and adding important information to the experiment since an additional dimension of spectral characterization is now available to complement the hydrodynamic information. The new detector avoids tedious repeats of experiments at different wavelengths and opens up new avenues for the solution-based investigation of complex mixtures. In this chapter, we describe the capabilities, characteristics, and applications of the new detector design with biopolymers as the focus of study. We show data from two different MWL detectors and discuss strengths and weaknesses of differences in the hardware and different data acquisition modes. Also, difficulties with fiber optic applications in the UV are discussed. Data quality is compared across platforms. PMID:26412645

  10. The decision to add a second hospital-based EMS helicopter.

    PubMed

    Friedman, R; Leicht, M J; Brotman, S

    1989-11-01

    An analysis of the first seven years of performance of our hospital-based emergency medical services (EMS) helicopter was conducted to evaluate the possible need for a second aircraft. A survey of seven hospitals currently operating two or more helicopters resulted in a consensus that one helicopter can effectively perform only 70 to 90 flights per month. The number of requests for our helicopter service has increased 148% from 610 to 1,512 in seven years while the number of completed missions has increased only 92% from 486 (40.5/month) to 935 (78/month). Requests denied due to inclement weather (265 in 1988) cannot be captured with a second visual-flight-rated (VFR) EMS helicopter; however, those missed due to maintenance requirements of the helicopter and overlapping requests (232 in 1988) can be captured. The need for a second aircraft exists when the number of requests for the service grows while the number of captured flights plateaus. Our data and industry survey suggests this will occur at 75 captured flights per month. Affordability and continued overall growth of trauma and other critical care referrals to the base hospital(s) is mandatory. This study provides a model for hospital-based EMS helicopter operators to apply to the decision whether to add a second aircraft. PMID:10296622

  11. Predictors of life satisfaction among Asian American adolescents- analysis of add health data.

    PubMed

    Huang, Jui-Yen; Wang, Kuan-Yuan; Ringel-Kulka, Tamar

    2015-01-01

    Life satisfaction correlates with adolescent risk taking behavior and their outcomes in adulthood. Despite the fast rise in numbers of Asian adolescents in the U.S., the predictors of their life satisfaction are not well understood. This study examined the relationship between several demographic and contextual factors and global life satisfaction among this population. Data were derived from the National Longitudinal Study of Adolescent Health (Add Health), a nationally representative probability sample of US adolescents. Bivariate and multivariable logistic regression was conducted to evaluate hypothesized predictors of global life satisfaction of Asian American adolescents. All analyses were conducted using STATA version 11. After exclusion of cases with missing values, 1021 Asian American adolescents were studied. Self- rated health, self-esteem, perceived neighborhood quality, parental support and peer support were significantly and positively related to better global life satisfaction. However, after controlling for other factors, only self-esteem (adjusted odds ratio [aOR]: 4.76; 95% confidence interval [CI]: 2.86-8.33) and perceived peer support (aOR: 2.76; 95% CI: 1.33-5.76) significantly predicted higher life satisfaction. Peer support and adolescents' self-concept are strongly correlated with Asian American adolescents' subjective well-being. To promote the wellness of this population, culturally sensitive strategies in developing peer relationship and healthy self-concept may be effective. More studies are needed for subgroup comparison of various ethnicities among Asian American adolescents. PMID:25992312

  12. PKSolver: An add-in program for pharmacokinetic and pharmacodynamic data analysis in Microsoft Excel.

    PubMed

    Zhang, Yong; Huo, Meirong; Zhou, Jianping; Xie, Shaofei

    2010-09-01

    This study presents PKSolver, a freely available menu-driven add-in program for Microsoft Excel written in Visual Basic for Applications (VBA), for solving basic problems in pharmacokinetic (PK) and pharmacodynamic (PD) data analysis. The program provides a range of modules for PK and PD analysis including noncompartmental analysis (NCA), compartmental analysis (CA), and pharmacodynamic modeling. Two special built-in modules, multiple absorption sites (MAS) and enterohepatic circulation (EHC), were developed for fitting the double-peak concentration-time profile based on the classical one-compartment model. In addition, twenty frequently used pharmacokinetic functions were encoded as a macro and can be directly accessed in an Excel spreadsheet. To evaluate the program, a detailed comparison of modeling PK data using PKSolver and professional PK/PD software package WinNonlin and Scientist was performed. The results showed that the parameters estimated with PKSolver were satisfactory. In conclusion, the PKSolver simplified the PK and PD data analysis process and its output could be generated in Microsoft Word in the form of an integrated report. The program provides pharmacokinetic researchers with a fast and easy-to-use tool for routine and basic PK and PD data analysis with a more user-friendly interface.

  13. CosmoCalc: An Excel add-in for cosmogenic nuclide calculations

    NASA Astrophysics Data System (ADS)

    Vermeesch, Pieter

    2007-08-01

    As dating methods using Terrestrial Cosmogenic Nuclides (TCN) become more popular, the need arises for a general-purpose and easy-to-use data reduction software. The CosmoCalc Excel add-in calculates TCN production rate scaling factors (using Lal, Stone, Dunai, and Desilets methods); topographic, snow, and self-shielding factors; and exposure ages, erosion rates, and burial ages and visualizes the results on banana-style plots. It uses an internally consistent TCN production equation that is based on the quadruple exponential approach of Granger and Smith (2000). CosmoCalc was designed to be as user-friendly as possible. Although the user interface is extremely simple, the program is also very flexible, and nearly all default parameter values can be changed. To facilitate the comparison of different scaling factors, a set of converter tools is provided, allowing the user to easily convert cut-off rigidities to magnetic inclinations, elevations to atmospheric depths, and so forth. Because it is important to use a consistent set of scaling factors for the sample measurements and the production rate calibration sites, CosmoCalc defines the production rates implicitly, as a function of the original TCN concentrations of the calibration site. The program is best suited for 10Be, 26Al, 3He, and 21Ne calculations, although basic functionality for 36Cl and 14C is also provided. CosmoCalc can be downloaded along with a set of test data from http://cosmocalc.googlepages.com.

  14. Predictors of life satisfaction among Asian American adolescents- analysis of add health data.

    PubMed

    Huang, Jui-Yen; Wang, Kuan-Yuan; Ringel-Kulka, Tamar

    2015-01-01

    Life satisfaction correlates with adolescent risk taking behavior and their outcomes in adulthood. Despite the fast rise in numbers of Asian adolescents in the U.S., the predictors of their life satisfaction are not well understood. This study examined the relationship between several demographic and contextual factors and global life satisfaction among this population. Data were derived from the National Longitudinal Study of Adolescent Health (Add Health), a nationally representative probability sample of US adolescents. Bivariate and multivariable logistic regression was conducted to evaluate hypothesized predictors of global life satisfaction of Asian American adolescents. All analyses were conducted using STATA version 11. After exclusion of cases with missing values, 1021 Asian American adolescents were studied. Self- rated health, self-esteem, perceived neighborhood quality, parental support and peer support were significantly and positively related to better global life satisfaction. However, after controlling for other factors, only self-esteem (adjusted odds ratio [aOR]: 4.76; 95% confidence interval [CI]: 2.86-8.33) and perceived peer support (aOR: 2.76; 95% CI: 1.33-5.76) significantly predicted higher life satisfaction. Peer support and adolescents' self-concept are strongly correlated with Asian American adolescents' subjective well-being. To promote the wellness of this population, culturally sensitive strategies in developing peer relationship and healthy self-concept may be effective. More studies are needed for subgroup comparison of various ethnicities among Asian American adolescents.

  15. Assessing psychological flexibility: what does it add above and beyond existing constructs?

    PubMed

    Gloster, Andrew T; Klotsche, Jens; Chaker, Samia; Hummel, Katrin V; Hoyer, Jürgen

    2011-12-01

    The construct of psychological flexibility (PF) is a central concept in acceptance and commitment therapy. It is defined as the process of contacting the present moment fully as a conscious human being and persisting in or changing behavior in the service of chosen values. PF is hypothesized to be an important aspect of healthy psychological functioning. Despite its potential importance, the distinctness of PF from other constructs has not been adequately demonstrated, and psychometric evaluations of measures designed to assess it are limited. This study aimed at extending current knowledge about PF by examining the construct in 2 help-seeking samples, including panic disorder with agoraphobia (n = 368), clinically relevant social phobia (n = 209), and 2 nonclinical samples including students (n = 495) and individuals visiting an employment office (n = 95). Results across all samples indicate that PF, as measured by the Acceptance and Action Questionnaire (2nd version; AAQ-II), is a unitary construct with a 1 factor model. PF correlated with other variables largely consistent with predictions, differentiated patients from healthy controls, and showed preliminary indications of treatment sensitivity. Incremental validity was partially demonstrated, especially for indices of functioning. Surprisingly, PF also explained unique variance above more established measures for some indices of symptomatology. Results suggest that PF adds some incremental clinical validity, yet further and more stringent tests are required to fully elucidate its strengths and limitations.

  16. Aerodynamic drag reduction tests on a full-scale tractor-trailer combination with several add-on devices

    NASA Technical Reports Server (NTRS)

    Montoya, L. C.; Steers, L. L.

    1974-01-01

    Aerodynamic drag tests were performed on a conventional cab-over-engine tractor with a 45-foot trailer and five commercially available or potentially available add-on devices using the coast-down method. The tests ranged in velocity from approximately 30 miles per hour to 65 miles per hour and included some flow visualization. A smooth, level runway at Edwards Air Force Base was used for the tests, and deceleration measurements were taken with both accelerometers and stopwatches. An evaluation of the drag reduction results obtained with each of the five add-on devices is presented.

  17. Liquid-crystal-on-silicon-based optical add/drop multiplexer for orbital-angular-momentum-multiplexed optical links.

    PubMed

    Huang, Hao; Yue, Yang; Yan, Yan; Ahmed, Nisar; Ren, Yongxiong; Tur, Moshe; Willner, Alan E

    2013-12-01

    We designed an optical add/drop multiplexer for orbital-angular-momentum (OAM)-multiplexed data links by taking advantage of the ring-shaped intensity profile of OAM beams. We demonstrated adding/dropping a single OAM beam from three multiplexed OAM beams using liquid-crystal-on-silicon-based diffraction optical elements. For multiplexed OAM beams carrying 100 Gbit/s quadrature phase-shift-keying data, a power penalty of <2 dB is observed to achieve a bit-error rate of 2.0×10(-3) for each channel of the add/drop multiplexer.

  18. Add-on prednisolone in the management of cervical lymph node tuberculosis.

    PubMed

    Bunkar, Moti Lal; Agnihotri, Shashi Prakash; Gupta, Prahlad Ral; Arya, Savita

    2016-04-01

    Studies defining role of systemic steroids in routine management of cervical lymph node tuberculosis (CLNTB) are too few and inconclusive. The present study was carried out to define the role of add-on prednisolone in the management of CLNTB. Patients of CLNTB were randomized into two groups. Group I patients received DOTS Category I treatment along with prednisolone 1mg/kg for first 4 weeks and then tapered down. Group II patients received DOTS Category I treatment along with placebo. Patients were kept under close follow up for 6 months. Response to therapy and adverse drug reactions, if any, were recorded. A total of 120 patients completed the study protocol. The two groups were similar with respect to age, sex, smoking, alcoholism, and clinical profile (p>0.5). At 2 months, 54 out of 60 patients in Group I showed symptom relief when compared with 44 out of 60 patients in Group II (p<0.001). Abscess, sinus, and/or appearance of new lymph node/s were noted in 3 and 13 patients in Group I and Group II, respectively (p<0.001). Complete resolution was seen in 57 patients in Group I when compared with only 40 patients of Group II and sequel in form of residual LN was noted in three patients of Group I when compared with 20 in Group II (p<0.001). Gastrointestinal side effects were reported by higher number of patients in Group I but skin rashes and joint pain were fewer when compared with Group II (p>0.05). All the adverse reactions were transient and amenable to symptomatic treatment. PMID:27451818

  19. What can neuromorphic event-driven precise timing add to spike-based pattern recognition?

    PubMed

    Akolkar, Himanshu; Meyer, Cedric; Clady, Zavier; Marre, Olivier; Bartolozzi, Chiara; Panzeri, Stefano; Benosman, Ryad

    2015-03-01

    This letter introduces a study to precisely measure what an increase in spike timing precision can add to spike-driven pattern recognition algorithms. The concept of generating spikes from images by converting gray levels into spike timings is currently at the basis of almost every spike-based modeling of biological visual systems. The use of images naturally leads to generating incorrect artificial and redundant spike timings and, more important, also contradicts biological findings indicating that visual processing is massively parallel, asynchronous with high temporal resolution. A new concept for acquiring visual information through pixel-individual asynchronous level-crossing sampling has been proposed in a recent generation of asynchronous neuromorphic visual sensors. Unlike conventional cameras, these sensors acquire data not at fixed points in time for the entire array but at fixed amplitude changes of their input, resulting optimally sparse in space and time-pixel individually and precisely timed only if new, (previously unknown) information is available (event based). This letter uses the high temporal resolution spiking output of neuromorphic event-based visual sensors to show that lowering time precision degrades performance on several recognition tasks specifically when reaching the conventional range of machine vision acquisition frequencies (30-60 Hz). The use of information theory to characterize separability between classes for each temporal resolution shows that high temporal acquisition provides up to 70% more information that conventional spikes generated from frame-based acquisition as used in standard artificial vision, thus drastically increasing the separability between classes of objects. Experiments on real data show that the amount of information loss is correlated with temporal precision. Our information-theoretic study highlights the potentials of neuromorphic asynchronous visual sensors for both practical applications and theoretical

  20. Establishing a Near Term Lunar Farside Gravity Model via Inexpensive Add-on Navigation Payload

    NASA Technical Reports Server (NTRS)

    Folta, David; Mesarch, Michael; Miller, Ronald; Bell, David; Jedrey, Tom; Butman, Stanley; Asmar, Sami

    2007-01-01

    The Space Communications and Navigation, Constellation Integration Project (SCIP) is tasked with defining, developing, deploying and operating an evolving multi-decade communications and navigation (C/N) infrastructure including services and subsystems that will support both robotic and human exploration activities at the Moon. This paper discusses an early far side gravitational mapping service and related telecom subsystem that uses an existing spacecraft (WIND) and the Lunar Reconnaissance Orbiter (LRO) to collect data that would address several needs of the SCIP. An important aspect of such an endeavor is to vastly improve the current lunar gravity model while demonstrating the navigation and stationkeeping of a relay spacecraft. We describe a gravity data acquisition activity and the trajectory design of the relay orbit in an Earth-Moon L2 co-linear libration orbit. Several phases of the transfer from an Earth-Sun to the Earth-Moon region are discussed along with transfers within the Earth-Moon system. We describe a proposed, but not integrated, add-on to LRO scheduled to be launched in October of 2008. LRO provided a real host spacecraft against which we designed the science payload and mission activities. From a strategic standpoint, LRO was a very exciting first flight opportunity for gravity science data collection. Gravity Science data collection requires the use of one or more low altitude lunar polar orbiters. Variations in the lunar gravity field will cause measurable variations in the orbit of a low altitude lunar orbiter. The primary means to capture these induced motions is to monitor the Doppler shift of a radio signal to or from the low altitude spacecraft, given that the signal is referenced to a stable frequency reference. For the lunar far side, a secondary orbiting radio signal platform is required. We provide an in-depth look at link margins, trajectory design, and hardware implications. Our approach posed minimum risk to a host mission while

  1. Mozart K.448 acts as a potential add-on therapy in children with refractory epilepsy.

    PubMed

    Lin, Lung-Chang; Lee, Wei-Te; Wang, Chien-Hua; Chen, Hsiu-Lin; Wu, Hui-Chuan; Tsai, Chin-Lin; Wei, Ruey-Chang; Mok, Hin-Kiu; Weng, Chia-Fen; Lee, Mei-Wen; Yang, Rei-Cheng

    2011-03-01

    Mozart's Sonata for two pianos in D major, K.448 (Mozart K.448), has been shown to improve mental function, leading to what is known as the Mozart effect. Our previous work revealed that epileptiform discharges in children with epilepsy decreased during and immediately after listening to Mozart K.448. In this study, we evaluated the long-term effects of Mozart K.448 on children with refractory epilepsy. Eleven children with refractory epilepsy were enrolled. All of the patients were diagnosed as having had refractory epilepsy for more than 1 year (range =1 year to 6 years 4 months, mean =3 years 11 months) and had been receiving at least two antiepileptic drugs (AED). During the study period, they listened to Mozart K.448 once a day before bedtime for 6 months. Seizure frequencies were recorded 6 months before they started listening to this music and monthly during the study period. All of the patients remained on the same AEDs during the 6-month study period. Frequencies of seizures were compared before and after listening to Mozart K.448. Eight of eleven patients were seizure free (N=2) or had very good responses (N=6) after 6 months of listening to Mozart K.448. The remaining three (27.3%) showed minimal or no effect (effectiveness <50%; unmodified or worsened seizure frequency). The average seizure reduction was 53.6 ± 62.0%. There were no significant differences in seizure reduction with IQ, etiology, or gender. We conclude that Mozart K.448 should be further studied as a potential add-on therapy in the treatment of children with refractory epilepsy.

  2. Project DyAdd: classical eyeblink conditioning in adults with dyslexia and ADHD.

    PubMed

    Laasonen, Marja; Kauppinen, Jenni; Leppämäki, Sami; Tani, Pekka; Harno, Hanna; Hokkanen, Laura; Wikgren, Jan

    2012-11-01

    In this study of the project DyAdd (Adult Dyslexia and Attention Deficit Disorder in Finland), classical eyeblink conditioning (EBC) was investigated in both delay and trace paradigms in adults (18-55 years) with dyslexia (n = 37), attention deficit-hyperactivity disorder (ADHD; n = 21), their comorbid combination (n = 8), and healthy controls (n = 35). In addition, the profiles of three participants with a rare autosomal dominant cerebellar disease were assessed (episodic ataxia type 2, EA-2). We found that participants with dyslexia were overall slower learners than controls in eyeblink conditioning. Further, they were the only group that had a reduced number of CRs in mediotemporal-dependent trace paradigm compared to the more cerebellum-dependent delay paradigm. Second, ADHD was found to be related to larger CR amplitude. Third, those with a comorbid condition learned faster and manifested CRs that were not well timed. Fourth, the cerebellar patients showed nearly no conditioning at all. Correlations between EBC and various neuropsychological domains (phonological processing, reading, spelling, arithmetic, executive functions, attention, and fine motor control) over all participants resulted in significant relations only for the delay paradigm: Increased amount of reading errors related with later peak latency and increased amount of self-corrections in fine motor control related with larger response magnitude. Within those who conditioned, relations emerged only for the trace paradigm: better spelling was related to larger response magnitude. These results do not lend support to the cerebellar hypothesis of dyslexia. On the contrary, dyslexia in its pure form seems to be related to a relative dysfunction of a larger hippocampal-cerebellar network. Further, larger responses in the ADHD group are suggested to result from their lowered responding threshold.

  3. What can neuromorphic event-driven precise timing add to spike-based pattern recognition?

    PubMed

    Akolkar, Himanshu; Meyer, Cedric; Clady, Zavier; Marre, Olivier; Bartolozzi, Chiara; Panzeri, Stefano; Benosman, Ryad

    2015-03-01

    This letter introduces a study to precisely measure what an increase in spike timing precision can add to spike-driven pattern recognition algorithms. The concept of generating spikes from images by converting gray levels into spike timings is currently at the basis of almost every spike-based modeling of biological visual systems. The use of images naturally leads to generating incorrect artificial and redundant spike timings and, more important, also contradicts biological findings indicating that visual processing is massively parallel, asynchronous with high temporal resolution. A new concept for acquiring visual information through pixel-individual asynchronous level-crossing sampling has been proposed in a recent generation of asynchronous neuromorphic visual sensors. Unlike conventional cameras, these sensors acquire data not at fixed points in time for the entire array but at fixed amplitude changes of their input, resulting optimally sparse in space and time-pixel individually and precisely timed only if new, (previously unknown) information is available (event based). This letter uses the high temporal resolution spiking output of neuromorphic event-based visual sensors to show that lowering time precision degrades performance on several recognition tasks specifically when reaching the conventional range of machine vision acquisition frequencies (30-60 Hz). The use of information theory to characterize separability between classes for each temporal resolution shows that high temporal acquisition provides up to 70% more information that conventional spikes generated from frame-based acquisition as used in standard artificial vision, thus drastically increasing the separability between classes of objects. Experiments on real data show that the amount of information loss is correlated with temporal precision. Our information-theoretic study highlights the potentials of neuromorphic asynchronous visual sensors for both practical applications and theoretical

  4. The Psychiatric Assessment Schedule for Adult with Developmental Disability (PAS-ADD) Checklist: Reliability and Validity of French Version

    ERIC Educational Resources Information Center

    Gerber, F.; Carminati, G. Galli

    2013-01-01

    Background: The lack of psychometric measures of psychopathology especially in intellectual disabilities (ID) population was addressed by creation of the Psychiatric Assessment Schedule for Adult with Developmental Disability (PAS-ADD-10) in Moss et?al. This schedule is a structured interview designed for professionals in psychopathology. The…

  5. Marriage and Health in the Transition to Adulthood: Evidence for African Americans in the Add Health Study

    ERIC Educational Resources Information Center

    Harris, Kathleen Mullan; Lee, Hedwig; DeLeone, Felicia Yang

    2010-01-01

    This article explores the relationships among early marriage (before age 26 years), cohabitation, and health for African Americans and Whites during the transition to adulthood using the National Longitudinal Study of Adolescent Health (Add Health). The study examines three categories of health outcomes relevant to young adulthood: physical…

  6. Meeting the food, energy, and water demands of nine billion people: Will climate change add a new dimension?

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Climate change will add a new stress to our ability to produce food and supply water and energy for the expanding population. There is an emerging gap between the current production trends in food commodities around the world and the projected needs to meet the demands for the world population. This...

  7. 40 CFR 63.4362 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... organic compounds as carbon in the vent gas, as determined by Method 25 or Method 25A, ppmv, dry basis... gaseous organic emissions mass flow rate at the outlet(s) of the add-on control device, using Equation 1... paragraphs (a)(1) through (5) of this section. (1) Use Method 1 or 1A of appendix A to 40 CFR part 60,...

  8. 40 CFR 63.3545 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... appendix A to 40 CFR part 60 to subtract methane emissions from measured total gaseous organic mass... = Concentration of organic compounds as carbon in the vent gas, as determined by Method 25 or Method 25A, ppmvd... gaseous organic emissions mass flow rate at the inlet(s) to the add-on control device, using Equation 1...

  9. The Ethics of Researching Those Who Are Close to You: The Case of the Abandoned ADD Project

    ERIC Educational Resources Information Center

    Puchner, Laurel D.; Smith, Louis M.

    2008-01-01

    This paper explores the ethical issues involved when researchers attempt to study participants who are personally close to them. It describes a case in which two researchers decided to study the experiences respectively of their son and grandson, both with ADD. They had barely initiated the study when ethical concerns led them to abandon the…

  10. General Classroom Structural Interventions for Teaching Students with Attention Deficit Disorder-Hyperactivity Disorder (ADD-HD).

    ERIC Educational Resources Information Center

    Harrell, Chris

    This paper examines structural antecedent classroom interventions to assist general classroom teachers in educating children with Attention Deficit Disorder-Hyperactivity Disorder (ADD-HD). The effectiveness of early classroom intervention models is explored. Modifications to physical classroom arrangements are evaluated, including open…

  11. How to Combine Objectives and Methods of Evaluation in Iterative ILE Design: Lessons Learned from Designing Ambre-Add

    ERIC Educational Resources Information Center

    Nogry, S.; Jean-Daubias, S.; Guin, N.

    2012-01-01

    This article deals with evaluating an interactive learning environment (ILE) during the iterative-design process. Various aspects of the system must be assessed and a number of evaluation methods are available. In designing the ILE Ambre-add, several techniques were combined to test and refine the system. In particular, we point out the merits of…

  12. Helping Students with Disabilities Transition to College: 21 Tips for Students with LD and/or ADD/ADHD

    ERIC Educational Resources Information Center

    Connor, David J.

    2012-01-01

    Making the transition from high school to college poses challenges for most students. Moving from a secure, regulated world of secondary education into an unfamiliar environment requiring greater independence can be a destabilizing experience. For students with learning disabilities (LD) and/or Attention Deficit Disorder (ADD), managing this…

  13. Multi-mode fiber coarse WDM grating router using broadband add/drop filters for wavelength re-use

    SciTech Connect

    Patel, R R; Bond, S W; Larson, M C; Pocha, M D; Lowry, M E; Deri, R J

    1999-06-01

    We demonstrate a grating-router with 37nm channel spacing and 6nm FWHM in the 800-900nm range for WDM over multimode fiber. Broadband thin-film add/drop filters provide wavelength re-use enabling NxN fully non-blocking interconnection with N wavelengths.

  14. 76 FR 4399 - Joint Industry Plan; Order Approving Amendment To Add the BATS Y-Exchange, Inc. as Participant to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-25

    ... Regulation NMS). See Securities Exchange Act Release No. 44177 (April 12, 2001), 66 FR 19814 (April 17, 2001). \\4\\ See Securities Exchange Act Release No. 62896 (September 13, 2010), 75 FR 57088. II. Discussion... COMMISSION Joint Industry Plan; Order Approving Amendment To Add the BATS Y- Exchange, Inc. as Participant...

  15. Auditory Discrimination in Depth (ADD)[R]/Lindamood Phonemic Sequencing (LiPS)[R]. What Works Clearinghouse Intervention Report

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2007

    2007-01-01

    The "Auditory Discrimination in Depth (ADD) Program[R]" (currently called the "Lindamood Phonemic Sequencing (LiPS) Program[R]") is designed to teach students skills to successfully decode words and to identify individual sounds and blends in words. Initial activities engage students in discovering the lip, tongue, and mouth actions needed to…

  16. 40 CFR 63.9323 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... device emission destruction or removal efficiency? 63.9323 Section 63.9323 Protection of Environment... Pollutants for Engine Test Cells/Stands Testing and Initial Compliance Requirements § 63.9323 How do I determine the add-on control device emission destruction or removal efficiency? You must use the...

  17. EEG Power Spectra of Children with Dyslexia, Slow Learners, and Normally Reading Children with ADD during Verbal Processing.

    ERIC Educational Resources Information Center

    Ackerman, Peggy T.; And Others

    1994-01-01

    Electroencephalographic (EEG) power spectra were studied in two poor reader groups (dyslexia and slow learning) and a normal reading group with attention deficit disorder (ADD). In correlational analyses, the combination of greater low beta and less theta power significantly predicted better reading and spelling. Results suggest adequate readers…

  18. Insights into Chi recognition from the structure of an AddAB-type helicase–nuclease complex

    PubMed Central

    Saikrishnan, Kayarat; Yeeles, Joseph T; Gilhooly, Neville S; Krajewski, Wojciech W; Dillingham, Mark S; Wigley, Dale B

    2012-01-01

    In bacterial cells, processing of double-stranded DNA breaks for repair by homologous recombination is dependent upon the recombination hotspot sequence Chi and is catalysed by either an AddAB- or RecBCD-type helicase–nuclease. Here, we report the crystal structure of AddAB bound to DNA. The structure allows identification of a putative Chi-recognition site in an inactivated helicase domain of the AddB subunit. By generating mutant protein complexes that do not respond to Chi, we show that residues responsible for Chi recognition are located in positions equivalent to the signature motifs of a conventional helicase. Comparison with the related RecBCD complex, which recognizes a different Chi sequence, provides further insight into the structural basis for sequence-specific ssDNA recognition. The structure suggests a simple mechanism for DNA break processing, explains how AddAB and RecBCD can accomplish the same overall reaction with different sets of functional modules and reveals details of the role of an Fe–S cluster in protein stability and DNA binding. PMID:22307084

  19. 40 CFR Table 1 to Subpart IIIi of... - Operating Limits for Capture Systems and Add-On Control Devices

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 12 2011-07-01 2009-07-01 true Operating Limits for Capture Systems... 63—Operating Limits for Capture Systems and Add-On Control Devices If you are required to comply with... consistent with the manufacturer's recommendations. 3. Regenerative carbon adsorber a. The total...

  20. 40 CFR Table 1 to Subpart IIIi of... - Operating Limits for Capture Systems and Add-On Control Devices

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 13 2013-07-01 2012-07-01 true Operating Limits for Capture Systems... Subpart IIII of Part 63—Operating Limits for Capture Systems and Add-On Control Devices If you are... consistent with the manufacturer's recommendations. 3. Regenerative carbon adsorber a. The total...

  1. triADD: The Risk for Alcohol Abuse, Depression, and Diabetes Multimorbidity in the American Indian and Alaska Native Population

    ERIC Educational Resources Information Center

    Tann, Sheila S.; Yabiku, Scott T.; Okamoto, Scott K.; Yanow, Jessica

    2007-01-01

    This study examined the risk for alcoholism, diabetes, and depression (triADD) in American Indian/Alaska Native (AI/AN) populations in the U.S. Using the Behavioral Risk Factor Surveillance System, a series of descriptive statistics and regression models were used to examine the interrelationships among these disorders in AI/AN populations.…

  2. 42 CFR 82.16 - How will NIOSH add to monitoring data to remedy limitations of individual monitoring and missed...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES... PROGRAM ACT OF 2000 Dose Reconstruction Process § 82.16 How will NIOSH add to monitoring data to remedy... those described in the NIOSH Research Issues Workshop, 2 to estimate the missing component of dose...

  3. 40 CFR 63.4965 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... dioxide, and carbon monoxide content of exhaust gas in ANSI/ASME PTC 19.10-1981, “Flue and Exhaust Gas... device emission destruction or removal efficiency? 63.4965 Section 63.4965 Protection of Environment... Controls Option § 63.4965 How do I determine the add-on control device emission destruction or...

  4. 40 CFR 63.3545 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... also use as an alternative to Method 3B the manual method for measuring the oxygen, carbon dioxide, and... device emission destruction or removal efficiency? 63.3545 Section 63.3545 Protection of Environment... Option § 63.3545 How do I determine the add-on control device emission destruction or removal...

  5. 40 CFR 63.4766 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... also use as an alternative to Method 3B, the manual method for measuring the oxygen, carbon dioxide... device emission destruction or removal efficiency? 63.4766 Section 63.4766 Protection of Environment... Option § 63.4766 How do I determine the add-on control device emission destruction or removal...

  6. 40 CFR 63.4166 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., carbon dioxide, and carbon monoxide content of exhaust gas in ANSI/ASME, PTC 19.10-1981, “Flue and... device emission destruction or removal efficiency? 63.4166 Section 63.4166 Protection of Environment... Controls Option § 63.4166 How do I determine the add-on control device emission destruction or...

  7. 40 CFR 63.3545 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... also use as an alternative to Method 3B the manual method for measuring the oxygen, carbon dioxide, and... device emission destruction or removal efficiency? 63.3545 Section 63.3545 Protection of Environment... Option § 63.3545 How do I determine the add-on control device emission destruction or removal...

  8. 40 CFR 63.4166 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., carbon dioxide, and carbon monoxide content of exhaust gas in ANSI/ASME, PTC 19.10-1981, “Flue and... device emission destruction or removal efficiency? 63.4166 Section 63.4166 Protection of Environment... Controls Option § 63.4166 How do I determine the add-on control device emission destruction or...

  9. 40 CFR 63.4362 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., carbon dioxide, and carbon monoxide content of exhaust gas in ANSI/ASME, PTC 19.10-1981, “Flue and... device emission destruction or removal efficiency? 63.4362 Section 63.4362 Protection of Environment... § 63.4362 How do I determine the add-on control device emission destruction or removal efficiency?...

  10. 40 CFR 63.4965 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... an alternative to Method 3B, the manual method for measuring the oxygen, carbon dioxide, and carbon... device emission destruction or removal efficiency? 63.4965 Section 63.4965 Protection of Environment....4965 How do I determine the add-on control device emission destruction or removal efficiency? You...

  11. 40 CFR 63.4766 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... also use as an alternative to Method 3B, the manual method for measuring the oxygen, carbon dioxide... device emission destruction or removal efficiency? 63.4766 Section 63.4766 Protection of Environment... Option § 63.4766 How do I determine the add-on control device emission destruction or removal...

  12. 40 CFR 63.4166 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... also use as an alternative to Method 3B, the manual method for measuring the oxygen, carbon dioxide... device emission destruction or removal efficiency? 63.4166 Section 63.4166 Protection of Environment....4166 How do I determine the add-on control device emission destruction or removal efficiency? (a)...

  13. 40 CFR 63.4166 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... also use as an alternative to Method 3B, the manual method for measuring the oxygen, carbon dioxide... device emission destruction or removal efficiency? 63.4166 Section 63.4166 Protection of Environment....4166 How do I determine the add-on control device emission destruction or removal efficiency? (a)...

  14. 40 CFR 63.4166 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., carbon dioxide, and carbon monoxide content of exhaust gas in ANSI/ASME, PTC 19.10-1981, “Flue and... device emission destruction or removal efficiency? 63.4166 Section 63.4166 Protection of Environment... Controls Option § 63.4166 How do I determine the add-on control device emission destruction or...

  15. 40 CFR 63.4965 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... dioxide, and carbon monoxide content of exhaust gas in ANSI/ASME PTC 19.10-1981, “Flue and Exhaust Gas... device emission destruction or removal efficiency? 63.4965 Section 63.4965 Protection of Environment... Controls Option § 63.4965 How do I determine the add-on control device emission destruction or...

  16. 40 CFR 63.4362 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., carbon dioxide, and carbon monoxide content of exhaust gas in ANSI/ASME, PTC 19.10-1981, “Flue and... device emission destruction or removal efficiency? 63.4362 Section 63.4362 Protection of Environment... Requirements § 63.4362 How do I determine the add-on control device emission destruction or removal...

  17. 40 CFR 63.4965 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... dioxide, and carbon monoxide content of exhaust gas in ANSI/ASME PTC 19.10-1981, “Flue and Exhaust Gas... device emission destruction or removal efficiency? 63.4965 Section 63.4965 Protection of Environment... Controls Option § 63.4965 How do I determine the add-on control device emission destruction or...

  18. 40 CFR 63.4362 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., carbon dioxide, and carbon monoxide content of exhaust gas in ANSI/ASME, PTC 19.10-1981, “Flue and... device emission destruction or removal efficiency? 63.4362 Section 63.4362 Protection of Environment... Requirements § 63.4362 How do I determine the add-on control device emission destruction or removal...

  19. 40 CFR 63.3545 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... an alternative to Method 3B the manual method for measuring the oxygen, carbon dioxide, and carbon... device emission destruction or removal efficiency? 63.3545 Section 63.3545 Protection of Environment... How do I determine the add-on control device emission destruction or removal efficiency? You must...

  20. 40 CFR 63.4362 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., carbon dioxide, and carbon monoxide content of exhaust gas in ANSI/ASME, PTC 19.10-1981, “Flue and... device emission destruction or removal efficiency? 63.4362 Section 63.4362 Protection of Environment... Requirements § 63.4362 How do I determine the add-on control device emission destruction or removal...

  1. 40 CFR 63.4965 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... an alternative to Method 3B, the manual method for measuring the oxygen, carbon dioxide, and carbon... device emission destruction or removal efficiency? 63.4965 Section 63.4965 Protection of Environment....4965 How do I determine the add-on control device emission destruction or removal efficiency? You...

  2. 40 CFR 63.3545 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... also use as an alternative to Method 3B the manual method for measuring the oxygen, carbon dioxide, and... device emission destruction or removal efficiency? 63.3545 Section 63.3545 Protection of Environment... Option § 63.3545 How do I determine the add-on control device emission destruction or removal...

  3. 76 FR 37115 - Determination Concerning a Petition To Add a Class of Employees to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-24

    ... to add a class of employees from the Bliss & Laughlin Steel Company located at 110 Hopkins Street... located at 110 Hopkins Street, Buffalo, New York, for the period from January 1, 1951, through December 31..., Telephone 1-877-222-7570. Information requests can also be submitted by e-mail to DCAS@CDC.GOV . John...

  4. The harmonised data model for assessing Land Parcel Identification Systems compliance with requirements of direct aid and agri-environmental schemes of the CAP.

    PubMed

    Sagris, Valentina; Wojda, Piotr; Milenov, Pavel; Devos, Wim

    2013-03-30

    The EU Common Agricultural Policy (CAP) subsidies to farmers are administered through dedicated information systems, a part of which is the GIS-based Land Parcel Identification System (LPIS). The requirement to map and record land eligible for payments has led to a situation where the agricultural administrations have acquired a large amount of geographic data. As the geospatial community of data producers, custodians and users has grown during the last decades, so has the need to assess the quality and consistency of the LPIS towards the EU regulations on the CAP as well as for cross compliance with environmental legislation. In view of this, a LPIS Conceptual Model (LCM) is presented in this paper in order to address harmonisation and data quality needs. The ISO 19100 series standards on geoinformatics were used for LCM development, including an UML modelling approach and the handling of the quality of geographical information. This paper describes the core elements of the LCM and their integration with data supporting management of agri-environment schemes. Later, the paper shows how the LCM is used for conformity and quality checks of the member states' LPIS system; an Abstract Test Suite (ATS) for mapping the LCM model against existing system implementations was developed and tested in collaboration with several member states. PMID:23391811

  5. The harmonised data model for assessing Land Parcel Identification Systems compliance with requirements of direct aid and agri-environmental schemes of the CAP.

    PubMed

    Sagris, Valentina; Wojda, Piotr; Milenov, Pavel; Devos, Wim

    2013-03-30

    The EU Common Agricultural Policy (CAP) subsidies to farmers are administered through dedicated information systems, a part of which is the GIS-based Land Parcel Identification System (LPIS). The requirement to map and record land eligible for payments has led to a situation where the agricultural administrations have acquired a large amount of geographic data. As the geospatial community of data producers, custodians and users has grown during the last decades, so has the need to assess the quality and consistency of the LPIS towards the EU regulations on the CAP as well as for cross compliance with environmental legislation. In view of this, a LPIS Conceptual Model (LCM) is presented in this paper in order to address harmonisation and data quality needs. The ISO 19100 series standards on geoinformatics were used for LCM development, including an UML modelling approach and the handling of the quality of geographical information. This paper describes the core elements of the LCM and their integration with data supporting management of agri-environment schemes. Later, the paper shows how the LCM is used for conformity and quality checks of the member states' LPIS system; an Abstract Test Suite (ATS) for mapping the LCM model against existing system implementations was developed and tested in collaboration with several member states.

  6. Metabolic and other effects of pioglitazone as an add-on therapy to metformin in the treatment of polycystic ovary syndrome (PCOS).

    PubMed

    Valsamakis, Georgios; Lois, Kostas; Kumar, Sudhesh; Mastorakos, George

    2013-01-01

    Insulin resistance is a key pathogenic defect of the clustered metabolic disturbances seen in polycystic ovary syndrome (PCOS). Metformin is an insulin sensitizer acting in the liver and the peripheral tissues that ameliorates the metabolic and reproductive defects in PCOS. In addition, pioglitazone is an insulin sensitizer used in diabetes mellitus type 2 (T2DM), improving insulin resistance (IR) in adipose tissue and muscles. In T2DM, these drugs are also used as a combined treatment due to their "add-on effect" on insulin resistance. Although the beneficial role of troglitazone (a member of the thiazolidinediones (TZDs) family) in PCOS has been shown in the past, currently only pioglitazone is available in the market. A few small randomized controlled trials have directly compared the effectiveness of pioglitazone in women with PCOS, while there are a limited number of small studies that support the beneficial metabolic add-on effect of pioglitazone on metformin-treated PCOS women as compared to metformin or pioglitazone monotherapy. These findings suggest a potentially promising role for combined pioglitazone/metformin treatment in the management of PCOS in metformin-resistant patients. In view of recent concerns regarding pioglitazone usage and its associated health risk, we aim to compare the pros and cons of each drug regarding their metabolic and other hormonal effects in women with PCOS and to explore the possible beneficial effect of combined therapy in certain cases, taking into consideration the teratogenic effect of pioglitazone. Finally, we discuss the need for a randomized controlled trial that will evaluate the metabolic and other hormonal effects of combined metformin/pioglitazone treatment in PCOS with selective treatment targets.

  7. Loxapine Add-on for Adolescents and Adults with Autism Spectrum Disorders and Irritability

    PubMed Central

    Reed, Gregory; Cain, Sharon E.; Zhou, Xinghua; Barth, Francis X.; Aman, Michael G.; Palaguachi, Gladys I.; Mikhnev, Dmytro; Teng, Rujia; Andridge, Rebecca; Logan, Marilyn; Butler, Merlin G.; Han, Joan C.

    2015-01-01

    Abstract Objectives: Our clinical experience with low dose loxapine (5–15 mg/day) suggests promising efficacy and safety for irritability in autism spectrum disorders (ASD). We studied low dose loxapine prospectively in adolescents and adults with ASD and irritability. Additionally, we measured loxapine and metabolite concentrations, and brain-derived neurotrophic factor (BDNF) as a biomarker of neuromodulation. Methods: We performed a 12 week open trial of add-on loxapine in subjects, ages 13–65 years, diagnosed with ASD, and Aberrant Behavior Checklist-Irritability (ABC-I) subscale scores >14. Loxapine was dosed flexibly up to 15 mg daily, starting with 5 mg on alternate days. From weeks 1 to 6, other psychoactive medications were tapered if possible; from weeks 6 to 12, all medication doses were held stable. The primary outcome was the Clinical Global Impressions-Improvement subscale (CGI-I), ratings of Much Improved or Very Much Improved. Secondary outcomes were the ABC-I, Repetitive Behavior Scale-Revised, and Schalock Quality of Life scale. Serum BDNF and loxapine and metabolite concentrations were assayed. BDNF rs6265 was genotyped. Results: Sixteen subjects were enrolled; 12 completed all visits. Median age was 18 years (range 13–39). Median final loxapine dose was 7.5 mg/day (2.5–15). All 14 subjects (100%) with data at week 12 were rated as Much Improved on CGI-I at 12 weeks. Mean change on ABC-I at 12 weeks was −31%, p=0.01. Mean body mass index (BMI)-Z decreased between weeks 6 and 12, p=0.03. Side effects were minimal, and prolactin elevation occurred in only one subject. BDNF concentrations measured in 11 subjects increased significantly (p=0.04). Subjects with AG genotype for BDNF rs6265 required a lower dose of loxapine at study end, but had similar behavioral and BDNF concentration changes as the GG genotype. Conclusions: Low dose loxapine shows promise as a repurposed drug for irritability in ASD. Loxapine effects on BDNF warrant

  8. Insights from a national survey into why substance abuse treatment units add prevention and outreach services

    PubMed Central

    Wells, Rebecca; Lemak, Christy Harris; D'Aunno, Thomas A

    2006-01-01

    Background Previous studies have found that even limited prevention-related interventions can affect health behaviors such as substance use and risky sex. Substance abuse treatment providers are ideal candidates to provide these services, but typically have little or no financial incentive to do so. The purpose of this study was therefore to explore why some substance abuse treatment units have added new prevention and outreach services. Based on an ecological framework of organizational strategy, three categories of predictors were tested: (1) environmental, (2) unit-level, and (3) unit leadership. Results A lagged cross-sectional logistic model of 450 outpatient substance abuse treatment units revealed that local per capita income, mental health center affiliation, and clinical supervisors' graduate degrees were positively associated with likelihood of adding prevention-related education and outreach services. Managed care contracts and methadone treatment were negatively associated with addition of these services. No hospital-affiliated agencies added prevention and outreach services during the study period. Conclusion Findings supported the study's ecological perspective on organizational strategy, with factors at environmental, unit, and unit leadership levels associated with additions of prevention and outreach services. Among the significant predictors, ties to managed care payers and unit leadership graduate education emerge as potential leverage points for public policy. In the current sample, units with managed care contracts were less likely to add prevention and outreach services. This is not surprising, given managed care's emphasis on cost control. However, the association with this payment source suggests that public managed care programs might affects prevention and outreach differently through revised incentives. Specifically, government payers could explicitly compensate substance abuse treatment units in managed care contracts for prevention and

  9. DO QUASAR BROAD-LINE VELOCITY WIDTHS ADD ANY INFORMATION TO VIRIAL BLACK HOLE MASS ESTIMATES?

    SciTech Connect

    Croom, Scott M.

    2011-08-01

    We examine how much information measured broad-line widths add to virial black hole (BH) mass estimates for flux-limited samples of quasars. We do this by comparing the BH mass estimates to those derived by randomly reassigning the quasar broad-line widths to different objects and re-calculating the BH mass. For 9000 BH masses derived from the H{beta} line we find that the distributions of original and randomized BH masses in the M{sub BH}-redshift plane and the M{sub BH}-luminosity plane are formally identical. A two-dimensional Kolmogorov-Smirnov test does not find a difference at >90% confidence. For the Mg II line (32,000 quasars) we do find very significant differences between the randomized and original BH masses, but the amplitude of the difference is still small. The difference for the C IV line (14,000 quasars) is 2{sigma}-3{sigma} and again the amplitude of the difference is small. Subdividing the data into redshift and luminosity bins we find that the median absolute difference in BH mass between the original and randomized data is 0.025, 0.01, and 0.04 dex for H{beta}, Mg II, and C IV, respectively. The maximum absolute difference is always {<=}0.1 dex. We investigate whether our results are sensitive to corrections to Mg II virial masses, such as those suggested by Onken and Kollmeier. These corrections do not influence our results, other than to reduce the significance of the difference between original and randomized BH masses to only 1{sigma}-2{sigma} for Mg II. Moreover, we demonstrate that the correlation between mass residuals and Eddington ratio discussed by Onken and Kollmeier is more directly attributable to the slope of the relation between H{beta} and Mg II line width. The implication is that the measured quasar broad-line velocity widths provide little extra information, after allowing for the mean velocity width. In this case virial estimates are equivalent to M{sub BH}{proportional_to}L{sup {alpha}}, with L/L{sub Edd

  10. How acidic is the lidocaine we are injecting, and how much bicarbonate should we add?

    PubMed Central

    Frank, Simon G; Lalonde, Donald H

    2012-01-01

    BACKGROUND: The infiltration of local anesthetics can be painful, which is likely due, in part, to their acidity. In spite of a Cochrane study that recommended neutralizing lidocaine with bicarbonate to decrease the pain of injection, not many surgeons have adopted the practice, and there are many ‘recipes’ for how much bicarbonate one should add. OBJECTIVE: To determine the acidity of lidocaine and the correct ratio of bicarbonate that should be added to neutralize lidocaine to achieve body pH. METHODS: Fifty samples each of commonly used anesthetics (lidocaine 1% and 2%, with and without epinephrine 1:100,000) were obtained and tested for pH. Data were also analyzed according to whether the vials had been previously opened. Ten additional samples of lidocaine 1% with 1:100,000 epinephrine were titrated against sodium bicarbonate 8.4% and tested for pH and the presence of precipitate. RESULTS: A solution of 1% lidocaine with 1:100,000 epinephrine had a mean (± SD) pH of 4.24±0.42, and 2% lidocaine with 1:100,000 epinephrine had a mean pH of 3.93±0.43. Plain 1% lidocaine had a pH of 6.09±0.16, and plain 2% lidocaine had a pH of 6.00±0.27. Epinephrine-containing solutions were more acidic when they had been previously opened. One per cent lidocaine with epinephrine required 8.4% sodium bicarbonate at a ratio of 1.1 mL:10 mL to 1.8 mL:10 mL to achieve the target tissue pH of 7.38 to 7.62. CONCLUSION: Lidocaine with epinephrine was approximately 1000 times more acidic than subcutaneous tissue. The addition of bicarbonate to the local anesthetic solution is simple to perform and is inexpensive. The proper volume ratio of 8.4% sodium bicarbonate to 1% lidocaine with 1:100,000 epinephrine is approximately 1 mL:10 mL. Surgeons should be more aware of the simplicity and value of buffering with bicarbonate to decrease the pain of injection. PMID:23730153

  11. Grain mantles: The impact on grain evolution and selective extinction

    NASA Technical Reports Server (NTRS)

    Joseph, Charles L.

    1989-01-01

    Depletion studies are used to infer the presence of mantles and to constrain grain evolutionary models in the diffuse interstellar medium. The presence of these mantles appears to be important in the evolution of the grains inside diffuse as well as dense clouds. In dense clouds where the element-to-element abundances sometimes differ from those found in diffuse clouds, empirical relationships are starting to emerge between gas abundances and various types of peculiar selective extinction. These peculiar extinction curves may be the results of nonvolatile mantle formation on grain cores or may reflect chemical differences due to variations in the intrinsic metalicity from one cloud to another. A simple model of the time evolution of a parcel of gas and dust as observed by the depletion of two elements is presented. Different studies of grain evolution and selective extinction are discussed and compared.

  12. Parcellation of parietal cortex: convergence between lesion-symptom mapping and mapping of the intact functioning brain.

    PubMed

    Vandenberghe, Rik; Gillebert, Céline R

    2009-05-16

    Spatial-attentional deficits are highly prevalent following stroke. They can be clinically detected by means of conventional bedside tests such as target cancellation, line bisection and the visual extinction test. Until recently, lesion mapping studies and functional imaging of the intact brain did not agree very well on exactly which parietal areas play a key role in selective attention: the inferior parietal lobule or the intraparietal sulcus. Recently, the use of a contrastive approach in patients akin to that commonly used in functional imaging studies in healthy volunteers together with voxel-based lesion-symptom mapping have allowed to bring the patient lesion mapping much closer to the functional imaging results obtained in healthy controls. In this review we focus on converging evidence obtained from patient lesion studies and from fMRI studies in the intact brain in humans. This has yielded novel insights into the functional segregation between the middle third of the intraparietal sulcus, the superior parietal lobule and the temporoparietal junction in the intact brain and also enhanced our understanding of the pathogenetic mechanisms underlying deficits arising in patients. PMID:19118580

  13. Add-Ons: The Ultimate Guide to Peripherals for the Blind Computer User.

    ERIC Educational Resources Information Center

    Croft, Diane L., Ed.

    Detailed product information on peripherals for the blind computer user is provided and applications, availability, reliability, price, and selection considerations are described. Chapters address the following topics and product categories: (1) scanners (optical character readers, Kurzweil Reading Machine); (2) a buyer's guide to modems; (3)…

  14. Selection of independent components based on cortical mapping of electromagnetic activity

    NASA Astrophysics Data System (ADS)

    Chan, Hui-Ling; Chen, Yong-Sheng; Chen, Li-Fen

    2012-10-01

    Independent component analysis (ICA) has been widely used to attenuate interference caused by noise components from the electromagnetic recordings of brain activity. However, the scalp topographies and associated temporal waveforms provided by ICA may be insufficient to distinguish functional components from artifactual ones. In this work, we proposed two component selection methods, both of which first estimate the cortical distribution of the brain activity for each component, and then determine the functional components based on the parcellation of brain activity mapped onto the cortical surface. Among all independent components, the first method can identify the dominant components, which have strong activity in the selected dominant brain regions, whereas the second method can identify those inter-regional associating components, which have similar component spectra between a pair of regions. For a targeted region, its component spectrum enumerates the amplitudes of its parceled brain activity across all components. The selected functional components can be remixed to reconstruct the focused electromagnetic signals for further analysis, such as source estimation. Moreover, the inter-regional associating components can be used to estimate the functional brain network. The accuracy of the cortical activation estimation was evaluated on the data from simulation studies, whereas the usefulness and feasibility of the component selection methods were demonstrated on the magnetoencephalography data recorded from a gender discrimination study.

  15. A method to add richness to the National Landslide Database of Great Britain

    NASA Astrophysics Data System (ADS)

    Taylor, Faith; Freeborough, Katy; Malamud, Bruce; Demeritt, David

    2014-05-01

    2012, 72 of these resulted in additions to the BGS NLD and 4 in amendments to previously collected information. This raises the total number of landslides reported in 2012 from 186 to 258. Using the increased presence of landslides in the news and social media, 2012 had already resulted in the largest number of landslides for a given year being recorded by BGS in the NLD. With the additions from this current study to the NLD, we estimate that the annual total number of landslides was around six times higher in 2012 than the average annual total between 2006 and 2011. Years prior to 2012 plan to be revisited using this method, and more broadly, this method of searching newspaper archives could be applied to many other natural hazards to add richness to databases of historical events and improve our understanding of hazard occurrence and impact.

  16. Mineralogical and chemical characteristics of the bentonite in the A2 test parcel of the LOT field experiments at Äspö HRL, Sweden

    NASA Astrophysics Data System (ADS)

    Olsson, Siv; Karnland, Ola

    The Long Term Test of Buffer Material (LOT) project at the Äspö Hard Rock Laboratory, Sweden, is a series of medium-scale field experiments focused on validating models and hypotheses concerning long term processes in the bentonite buffer of a repository for high-level radioactive waste. The test parcels emplaced in crystalline bedrock consist of blocks of compacted MX80 bentonite embedding a Cu-tube equipped with a heater to simulate the heat generation from radionuclide decay. The A2 test parcel had been subjected to elevated temperature (up to 130 °C) and hydration by a Na-Ca-Cl type groundwater for almost 6 years when it was retrieved to be analysed. The analyses included determinations of chemical composition, cation exchange capacity (CEC), exchangeable cations and mineralogy. Both the bulk bentonite and dialysed, homo-ionic Na-clay (<2 μm and <0.2 μm fractions) were analysed when relevant. Sulphate was redistributed in the heated part of the buffer under the thermal and hydration gradients that prevailed during the test period. Anhydrite accumulated in the warmer parts, whereas gypsum was dissolved in the peripheral parts of the buffer where water was supplied. Carbonate dissolution increased with temperature in the warmest parts, whereas chloride behaved conservatively in all blocks. Cu was incorporated in the bentonite matrix at the surface of the Cu-tube indicating some corrosion, which may be explained by reactions in an early stage of the test when trapped oxygen existed in the system. Along with the dissolution/precipitation reactions the porewater composition changed, which resulted in replacement of exchangeable sodium by calcium and magnesium in the warmest zone. Also Mg in the clay (<2 μm and <0.2 μm fractions) displays a clear gradient with peak values at the heater. Because several of the alternative sinks for Mg were eliminated in the sample preparation prior to the chemical analysis (purified clay fractions, removal of carbonates, Na

  17. Webb report adds support for choosing LPG as a motor fuel

    SciTech Connect

    Not Available

    1990-01-01

    This article discusses a study on choosing propane and butane as an alternate transportation fuel (ATF). According to this article, the results of the study indicate that propane and butane have met two of the challenges facing selection of an ATF: there is a ready supply of the product and conversion equipment is easily available. Primary goals identified by the study are presented and discussed.

  18. An Improved Equation for TBS and ADD: Establishing a Reliable Postmortem Interval Framework for Casework and Experimental Studies.

    PubMed

    Moffatt, Colin; Simmons, Tal; Lynch-Aird, Jeanne

    2016-01-01

    Megyesi et al.'s (J Forensic Sci, 2005, 50, 618) paper was important to forensic anthropology as it introduced a quantitative framework for estimating time since death in human cadavers, based upon physical appearance by way of scoring on a novel scale. However, errors concerning rounding, temperature scale, and incorrect use of a statistical regression model render their predictive formula unusable. Based upon only their more reliable data, a more appropriate regression model to predict accumulated degree days (ADD) from total body score (TBS) is presented. The new model is also a superior fit (r(2)  = 0.91) and produces markedly narrower confidence intervals than the original, which also allowed impossible, negative ADD values. Explanations of the shortcomings in the original analysis and calculations are presented, which it is hoped will help forensic scientists avoid making similar mistakes.

  19. Connectivity-based parcellation increases network detection sensitivity in resting state fMRI: An investigation into the cingulate cortex in autism.

    PubMed

    Balsters, Joshua H; Mantini, Dante; Apps, Matthew A J; Eickhoff, Simon B; Wenderoth, Nicole

    2016-01-01

    Although resting state fMRI (RS-fMRI) is increasingly used to generate biomarkers of psychiatric illnesses, analytical choices such as seed size and placement can lead to variable findings. Seed placement especially impacts on RS-fMRI studies of Autism Spectrum Disorder (ASD), because individuals with ASD are known to possess more variable network topographies. Here, we present a novel pipeline for analysing RS-fMRI in ASD using the cingulate cortex as an exemplar anatomical region of interest. Rather than using seeds based on previous literature, or gross morphology, we used a combination of structural information, task-independent (RS-fMRI) and task-dependent functional connectivity (Meta-Analytic Connectivity Modeling) to partition the cingulate cortex into six subregions with unique connectivity fingerprints and diverse behavioural profiles. This parcellation was consistent between groups and highly replicable across individuals (up to 93% detection) suggesting that the organisation of cortico-cingulo connections is highly similar between groups. However, our results showed an age-related increase in connectivity between the anterior middle cingulate cortex and right lateral prefrontal cortex in ASD, whilst this connectivity decreased in controls. There was also a Group × Grey Matter (GM) interaction, showing increased connectivity between the anterior cingulate cortex and the rectal gyrus in concert with increasing rectal gyrus GM in controls. By comparing our approach to previously established methods we revealed that our approach improves network detection in both groups, and that the ability to detect group differences using 4 mm radius spheres varies greatly with seed placement. Using our multi-modal approach we find disrupted cortico-cingulo circuits that, based on task-dependent information, may contribute to ASD deficits in attention and social interaction. Moreover, we highlight how more sensitive approaches to RS-fMRI are crucial for establishing

  20. Connectivity-based parcellation increases network detection sensitivity in resting state fMRI: An investigation into the cingulate cortex in autism

    PubMed Central

    Balsters, Joshua H.; Mantini, Dante; Apps, Matthew A.J.; Eickhoff, Simon B.; Wenderoth, Nicole

    2016-01-01

    Although resting state fMRI (RS-fMRI) is increasingly used to generate biomarkers of psychiatric illnesses, analytical choices such as seed size and placement can lead to variable findings. Seed placement especially impacts on RS-fMRI studies of Autism Spectrum Disorder (ASD), because individuals with ASD are known to possess more variable network topographies. Here, we present a novel pipeline for analysing RS-fMRI in ASD using the cingulate cortex as an exemplar anatomical region of interest. Rather than using seeds based on previous literature, or gross morphology, we used a combination of structural information, task-independent (RS-fMRI) and task-dependent functional connectivity (Meta-Analytic Connectivity Modeling) to partition the cingulate cortex into six subregions with unique connectivity fingerprints and diverse behavioural profiles. This parcellation was consistent between groups and highly replicable across individuals (up to 93% detection) suggesting that the organisation of cortico-cingulo connections is highly similar between groups. However, our results showed an age-related increase in connectivity between the anterior middle cingulate cortex and right lateral prefrontal cortex in ASD, whilst this connectivity decreased in controls. There was also a Group × Grey Matter (GM) interaction, showing increased connectivity between the anterior cingulate cortex and the rectal gyrus in concert with increasing rectal gyrus GM in controls. By comparing our approach to previously established methods we revealed that our approach improves network detection in both groups, and that the ability to detect group differences using 4 mm radius spheres varies greatly with seed placement. Using our multi-modal approach we find disrupted cortico-cingulo circuits that, based on task-dependent information, may contribute to ASD deficits in attention and social interaction. Moreover, we highlight how more sensitive approaches to RS-fMRI are crucial for establishing

  1. Green-roof as a solution to solve stormwater management issues? Assessment on a long time period at the parcel scale

    NASA Astrophysics Data System (ADS)

    Versini, P.-A.; Petrucci, G.; de Gouvello, B.

    2014-09-01

    Experimental green-roof rainfall-runoff observations have shown a positive impact on stormwater management at the building scale; with a decrease in the peak discharge and a decrease in runoff volume. This efficiency of green-roofs varies from one rainfall event to another depending on precipitation characteristics and substrate antecedent conditions. Due to this variability, currently, green-roofs are rarely officially used as a regulation tool to manage stormwater. Indeed, regulation rules governing the connection to the stormwater network are usually based on absolute threshold values that always have to be respected: maximum areal flow-rate or minimum retention volume for example. In this context, the aim of this study is to illustrate how a green-roof could represent an alternative to solve stormwater management issues, if the regulation rules were further based on statistics. For this purpose, a modelling scheme has been established at the parcel scale to simulate the hydrological response of several roof configurations: impervious, strictly regulated (in terms of areal flow-rate or retention volume), and covered by different types of green-roof matter. Simulations were carried out on a long precipitation time period (23 years) that included a large and heterogeneous set of hydrometeorological conditions. Results obtained for the different roof configurations were compared. Based on the return period of the rainfall event, the probability to respect some regulation rules (defined from real situations) was assessed. They illustrate that green-roofs reduce stormwater runoff compared to an impervious roof surface and can guarantee the respect of the regulation rules in most of the cases. Moreover, their implementation can appear more realistic than that of other infrastructures strictly complying with regulations and demanding significant storage capacity.

  2. Changing spatial patterns of evapotranspiration and deep drainage in response to the interactions among impervious surface arrangement, soil characteristics, and weather on a residential parcel.

    NASA Astrophysics Data System (ADS)

    Voter, C. B.; Steven, L. I.

    2015-12-01

    The introduction impervious surfaces in urban areas is a key driver of hydrologic change. It is now well understood that the amount of "effective" impervious area directly connected to the storm sewer network is a better indicator of hydrologic behavior than the total amount of impervious area. Most studies in urban hydrology have focused on the relationship between impervious connectivity and stormwater runoff or other surface water flows, with the result that the effect on subsurface flow is not as well understood. In the field, we observe differences in soil moisture availability that are dependent on proximity to impervious features and significant from a root water uptake perspective, which indicates that parcel-scale subsurface and plant water fluxes may also be sensitive to fine-scaled heterogeneity in impervious surface arrangement and connectivity. We use ParFlow with CLM, a watershed model with fully integrated variably-saturated subsurface flow, overland flow, and land-surface processes, to explore the extent to which soil moisture, evapotranspiration, and deep drainage vary under various impervious surface arrangement and soil condition scenarios, as well as under a range of precipitation regimes. We investigate the effect of several impervious surface and soil characteristics, including general lot layout, downspout disconnect, and direction of driveway/sidewalk slope, and soil compaction. We show that that some impervious connectivity schemes transfer more water from impervious areas to pervious ones and promote localized recharge by developing well-defined, fast-moving wetting fronts that are able to penetrate the root zone. Enhanced infiltration is translated more directly to recharge in normal to wet years but partitioned more often to transpiration in dry years, leading to a nonlinear relationship among precipitation, runoff and recharge.

  3. Nucleus of the solitary tract in the C57BL/6J mouse: Subnuclear parcellation, chorda tympani nerve projections, and brainstem connections

    PubMed Central

    Ganchrow, Donald; Ganchrow, Judith R; Cicchini, Vanessa; Bartel, Dianna L; Kaufman, Daniel; Girard, David; Whitehead, Mark C

    2013-01-01

    The nucleus of the solitary tract (NST) processes gustatory and related somatosensory information rostrally and general viscerosensory information caudally. To compare its connections with those of other rodents, this study in the C57BL/6J mouse provides a subnuclear cytoarchitectonic parcellation (Nissl stain) of the NST into rostral, intermediate, and caudal divisions. Subnuclei are further characterized by NADPH staining and P2X2 immunoreactivity (IR). Cholera toxin subunit B (CTb) labeling revealed those NST subnuclei receiving chorda tympani nerve (CT) afferents, those connecting with the parabrachial nucleus (PBN) and reticular formation (RF), and those interconnecting NST subnuclei. CT terminals are densest in the rostral central (RC) and medial (M) subnuclei; less dense in the rostral lateral (RL) subnucleus; and sparse in the ventral (V), ventral lateral (VL), and central lateral (CL) subnuclei. CTb injection into the PBN retrogradely labels cells in the aforementioned subnuclei; RC and M providing the largest source of PBN projection neurons. Pontine efferent axons terminate mainly in V and rostral medial (RM) subnuclei. CTb injection into the medullary RF labels cells and axonal endings predominantly in V at rostral and intermediate NST levels. Small CTb injections within the NST label extensive projections from the rostral division to caudal subnuclei. Projections from the caudal division primarily interconnect subnuclei confined to the caudal division of the NST; they also connect with the area postrema. P2X2-IR identifies probable vagal nerve terminals in the central (Ce) subnucleus in the intermediate/caudal NST. Ce also shows intense NADPH staining and does not project to the PBN. J. Comp. Neurol. 522:1565–1596, 2014. PMID:24151133

  4. 40 CFR 63.4566 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... outlet of the add-on control device simultaneously, using either Method 25 or 25A of appendix A to 40 CFR...) through (5) of this section. (1) Use Method 1 or 1A of appendix A to 40 CFR part 60, as appropriate, to... to 40 CFR part 60, as appropriate, to measure gas volumetric flow rate. (3) Use Method 3, 3A, or...

  5. 40 CFR 63.4566 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... outlet of the add-on control device simultaneously, using either Method 25 or 25A of appendix A to 40 CFR...) through (5) of this section. (1) Use Method 1 or 1A of appendix A to 40 CFR part 60, as appropriate, to... to 40 CFR part 60, as appropriate, to measure gas volumetric flow rate. (3) Use Method 3, 3A, or...

  6. The reliability of in-home measures of height and weight in large cohort studies: Evidence from Add Health

    PubMed Central

    Hussey, Jon M.; Nguyen, Quynh C.; Whitsel, Eric A.; Richardson, Liana J.; Halpern, Carolyn Tucker; Gordon-Larsen, Penny; Tabor, Joyce W.; Entzel, Pamela P.; Harris, Kathleen Mullan

    2015-01-01

    Background With the emergence of obesity as a global health issue an increasing number of major demographic surveys are collecting measured anthropometric data. Yet little is known about the characteristics and reliability of these data. Objectives We evaluate the accuracy and reliability of anthropometric data collected in the home during Wave IV of the National Longitudinal Study of Adolescent to Adult Health (Add Health), compare our estimates to national standard, clinic-based estimates from the National Health and Nutrition Examination Survey (NHANES) and, using both sources, provide a detailed anthropometric description of young adults in the United States. Methods The reliability of Add Health in-home anthropometric measures was estimated from repeat examinations of a random subsample of study participants. A digit preference analysis evaluated the quality of anthropometric data recorded by field interviewers. The adjusted odds of obesity and central obesity in Add Health vs. NHANES were estimated with logistic regression. Results Short-term reliabilities of in-home measures of height, weight, waist and arm circumference—as well as derived body mass index (BMI, kg/m2)—were excellent. Prevalence of obesity (37% vs. 29%) and central obesity (47% vs. 38%) was higher in Add Health than in NHANES while socio-demographic patterns of obesity and central obesity were comparable in the two studies. Conclusions Properly trained non-medical field interviewers can collect reliable anthropometric data in a nationwide, home visit study. This national cohort of young adults in the United States faces a high risk of early-onset chronic disease and premature mortality. PMID:26146486

  7. Efficacy and safety of muscarinic antagonists as add-on therapy for male lower urinary tract symptoms

    PubMed Central

    Li, Jinhong; Shi, Qingquan; Bai, Yunjin; Pu, Chunxiao; Tang, Yin; Yuan, Haichao; Wu, Yunjian; Wei, Qiang; Han, Ping

    2014-01-01

    Alpha-adrenoceptor antagonists (alpha-blockers) are widely prescribed to treat lower urinary tract symptoms (LUTS) in men but fail to ameliorate LUTS sufficiently, especially the storage symptoms related to frequency, urgency and nocturia. We performed a meta-analysis of randomised controlled trials (RCTs) comparing an alpha-blocker plus muscarinic antagonist with an alpha-blocker alone in male LUTS patients who were treated with alpha-blocker prior to randomisation. The review contained six randomised controlled trials (RCTs) that included a total of 2,208 male patients who were randomised to receive alpha-blocker plus muscarinic antagonist or alpha-blocker alone. The add-on group experienced significantly greater improvement in both total IPSS (International Prostate Symptom Score) and storage IPSS. Adverse events (AEs) were commonly experienced by both groups (41.6 vs. 33.3%) though they were not severe. Our meta-analysis indicated that muscarinic antagonists as add-on therapy alleviate LUTS, especially storage symptoms. The add-on therapy demonstrated safety and tolerability comparable with alpha-blocker monotherapy in male with LUTS. PMID:24492830

  8. The National Longitudinal Study of Adolescent to Adult Health (Add Health) Sibling Pairs Genome-Wide Data

    PubMed Central

    McQueen, Matthew B.; Boardman, Jason D.; Domingue, Benjamin W.; Smolen, Andrew; Tabor, Joyce; Killeya-Jones, Ley; Halpern, Carolyn T.; Whitsel, Eric A.; MullanHarris, Kathleen

    2014-01-01

    Here we provide a detailed description of the genome-wide information available on the National Longitudinal Study of Adolescent to Adult Health (Add Health) sibling pair subsample (Harris et al., 2012). A total of 2020 samples were genotyped (including duplicates) arising from 1946 Add Health individuals from the sibling pairs subsample. After various steps for quality control (QC) and quality assurance (QA), we have high quality genome-wide data available on 1,888 individuals. In this report, we first highlight theQC and QA steps that were taken to prune the data of poorly performing samples and genetic markers. We further estimate the pairwise biological relationships using genome-wide data and compare those estimates to the assumed relationships in Add Health. Additionally, using genome-wide data from knownregional reference populations from Europe, West Africa, North and South America, Japan and China, weestimate the relative genetic ancestry of the respondents. Finally, rather than conducting a traditional cross-sectional genome-wide association study (GWAS) of body mass index (BMI), we opted to utilize the extensivepublicly available genome-wide information to conduct a weighted genome-wide association study (GWAS) of longitudinal BMI while accounting for both family and ethnic variation. PMID:25378290

  9. The National Longitudinal Study of Adolescent to Adult Health (Add Health) sibling pairs genome-wide data.

    PubMed

    McQueen, Matthew B; Boardman, Jason D; Domingue, Benjamin W; Smolen, Andrew; Tabor, Joyce; Killeya-Jones, Ley; Halpern, Carolyn T; Whitsel, Eric A; Harris, Kathleen Mullan

    2015-01-01

    Here we provide a detailed description of the genome-wide information available on the National Longitudinal Study of Adolescent to Adult Health (Add Health) sibling pair subsample (Harris et al. in Twin Res Hum Genet 16:391-398, 2013). A total of 2,020 samples were genotyped (including duplicates) arising from 1946 Add Health individuals from the sibling pairs subsample. After various steps for quality control (QC) and quality assurance (QA), we have high quality genome-wide data available on 1,888 individuals. In this report, we first highlight the QC and QA steps that were taken to prune the data of poorly performing samples and genetic markers. We further estimate the pairwise biological relationships using genome-wide data and compare those estimates to the assumed relationships in Add Health. Additionally, using genome-wide data from known regional reference populations from Europe, West Africa, North and South America, Japan and China, we estimate the relative genetic ancestry of the respondents. Finally, rather than conducting a traditional cross-sectional genome-wide association study (GWAS) of body mass index (BMI), we opted to utilize the extensive publicly available genome-wide information to conduct a weighted GWAS of longitudinal BMI while accounting for both family and ethnic variation.

  10. 42 CFR 83.19 - How can the Secretary cancel or modify a final decision to add a class of employees to the Cohort?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... of 42 CFR part 82. (b) Before canceling a final decision to add a class or modifying a final decision... conducting dose reconstructions under 42 CFR part 82; the analysis will be performed consistently with the... decision to add a class of employees to the Cohort? 83.19 Section 83.19 Public Health PUBLIC HEALTH...

  11. 42 CFR 83.17 - How will the Secretary report a final decision to add a class of employees to the Cohort and any...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... add a class of employees to the Cohort and any action of Congress concerning the effect of the final... COMPENSATION PROGRAM ACT OF 2000 Procedures for Adding Classes of Employees to the Cohort § 83.17 How will the Secretary report a final decision to add a class of employees to the Cohort and any action of...

  12. 42 CFR 83.19 - How can the Secretary cancel or modify a final decision to add a class of employees to the Cohort?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... of 42 CFR part 82. (b) Before canceling a final decision to add a class or modifying a final decision... conducting dose reconstructions under 42 CFR part 82; the analysis will be performed consistently with the... decision to add a class of employees to the Cohort? 83.19 Section 83.19 Public Health PUBLIC HEALTH...

  13. 29 CFR 4903.6 - How will PBGC add interest, penalty charges, and administrative costs to a debt owed to PBGC?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... administrative costs on PBGC debts in accordance with the provisions of 31 U.S.C. 3717, 31 CFR 901.9 and other... 29 Labor 9 2011-07-01 2011-07-01 false How will PBGC add interest, penalty charges, and... Procedures To Collect Debts Owed to PBGC § 4903.6 How will PBGC add interest, penalty charges,...

  14. 42 CFR 83.17 - How will the Secretary report a final decision to add a class of employees to the Cohort and any...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... add a class of employees to the Cohort and any action of Congress concerning the effect of the final... COMPENSATION PROGRAM ACT OF 2000 Procedures for Adding Classes of Employees to the Cohort § 83.17 How will the Secretary report a final decision to add a class of employees to the Cohort and any action of...

  15. 40 CFR 63.4167 - How do I establish the emission capture system and add-on control device operating limits during...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 12 2011-07-01 2009-07-01 true How do I establish the emission capture... with Add-on Controls Option § 63.4167 How do I establish the emission capture system and add-on control... test to determine destruction efficiency according to § 63.4166. (c) Carbon adsorbers. If your...

  16. 40 CFR 63.3556 - How do I establish the emission capture system and add-on control device operating limits during...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 12 2011-07-01 2009-07-01 true How do I establish the emission capture.../outlet Concentration Option § 63.3556 How do I establish the emission capture system and add-on control... the emission stream for leakage. (d) Carbon adsorbers. If your add-on control device is a...

  17. 40 CFR 63.3546 - How do I establish the emission capture system and add-on control device operating limits during...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 12 2011-07-01 2009-07-01 true How do I establish the emission capture... Add-on Controls Option § 63.3546 How do I establish the emission capture system and add-on control... valves during internal inspections; and/or actual testing of the emission stream for leakage. (d)...

  18. 40 CFR 63.4167 - How do I establish the emission capture system and add-on control device operating limits during...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 13 2013-07-01 2012-07-01 true How do I establish the emission capture... Emission Rate with Add-on Controls Option § 63.4167 How do I establish the emission capture system and add... test to determine destruction efficiency according to § 63.4166. (c) Carbon adsorbers. If your...

  19. 40 CFR 63.4767 - How do I establish the emission capture system and add-on control device operating limits during...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 13 2013-07-01 2012-07-01 true How do I establish the emission capture... for the Emission Rate with Add-on Controls Option § 63.4767 How do I establish the emission capture...) Carbon adsorbers. If your add-on control device is a carbon adsorber, establish the operating...

  20. 40 CFR 63.3555 - How do I determine the outlet THC emissions and add-on control device emission destruction or...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... an alternative to Method 3B, the manual method for measuring the oxygen, carbon dioxide, and carbon... emissions and add-on control device emission destruction or removal efficiency? 63.3555 Section 63.3555... add-on control device emission destruction or removal efficiency? You must use the procedures and...

  1. 40 CFR 63.3555 - How do I determine the outlet THC emissions and add-on control device emission destruction or...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... an alternative to Method 3B, the manual method for measuring the oxygen, carbon dioxide, and carbon... emissions and add-on control device emission destruction or removal efficiency? 63.3555 Section 63.3555... add-on control device emission destruction or removal efficiency? You must use the procedures and...

  2. 40 CFR 63.3555 - How do I determine the outlet THC emissions and add-on control device emission destruction or...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... an alternative to Method 3B, the manual method for measuring the oxygen, carbon dioxide, and carbon... emissions and add-on control device emission destruction or removal efficiency? 63.3555 Section 63.3555... add-on control device emission destruction or removal efficiency? You must use the procedures and...

  3. Using the PhenX Toolkit to Add Standard Measures to a Study.

    PubMed

    Hendershot, Tabitha; Pan, Huaqin; Haines, Jonathan; Harlan, William R; Junkins, Heather A; Ramos, Erin M; Hamilton, Carol M

    2011-10-01

    The PhenX (consensus measures for Phenotypes and eXposures) Toolkit (https://www.phenxtoolkit.org/) offers high-quality, well-established measures of phenotypes and exposures for use by the scientific community. The Toolkit contains 295 measures drawn from 21 research domains (fields of research). The measures were selected by Working Groups of domain experts using a consensus process that included input from the scientific community. The Toolkit provides a description of each PhenX measure, the rationale for including it in the Toolkit, protocol(s) for collecting the measure, and supporting documentation. Users can browse by measures, domains, or collections, or can search the Toolkit using the Smart Query Tool. Once users have selected some measures, they can download a customized Data Collection Worksheet that specifies what information needs to be collected, and a Data Dictionary that describes each variable included in their Data Collection Worksheet. To help researchers find studies with comparable data, PhenX measures and variables are being mapped to studies in the database of Genotypes and Phenotypes (dbGaP).

  4. Natural selection and glucocorticoid physiology.

    PubMed

    Patterson, S H; Hahn, T P; Cornelius, J M; Breuner, C W

    2014-02-01

    Glucocorticoid hormones are considered potent modulators of trade-offs between reproduction and survival. As such, selection should affect glucocorticoid physiology, although relatively little is known about how selection may act on glucocorticoid profiles. In general, the evolution of physiology is less studied and less well understood than morphological or life history traits. Here, we used a long-term data set from a population of mountain white-crowned sparrows to estimate natural selection on glucocorticoid profiles. Our study suggests that survival selection favours higher hormone concentrations for multiple components of glucocorticoid physiology (both baseline and stress-induced glucocorticoid levels). Fecundity selection varies depending on the component of hypothalamic-pituitary-adrenal physiology; greater reproductive output was associated with higher baseline glucocorticoid levels, but lower stress-induced glucocorticoid levels. Additionally, the selection gradient was greater for glucocorticoids than for a morphological trait (wing length). These results support the hypothesis that stress-induced glucocorticoids increase survival over reproduction within a wild population (the CORT-trade-off hypothesis). Taken together, these results add to our knowledge of how selection operates on physiological traits and also provide an evolutionary and ecological perspective on several key open issues in the field of glucocorticoid physiology.

  5. Footprint Reduction Process: Using Remote Sensing and GIS Technologies to Identify Non-Contaminated Land Parcels on the Oak Ridge Reservation National Priorities List Site

    SciTech Connect

    Halsey, P.A.; Kendall, D.T.; King, A.L.; Storms, R.A.

    1998-12-09

    In 1989, the Agency for Toxic Substances and Disease Registry evaluated the entire 35,000-acre U. S: Department of Energy (DOE) Oak Ridge Reservation (ORR, located in Oak Ridge, TN) and placed it on the National Priorities List (NPL), making the ORR subject to Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) regulations. Although much of the ORR has not been impacted by previous federal activities, without investigation it is difficult to discern which parcels of land are free of surface contamination. In 1996, the DOE Oak Ridge Environmental Management Program (EM) funded the Footprint Reduction Project to: 1) develop a process to study the large areas of the ORR that are believed to be free of surface contamination and 2) initiate the delisting of the "clean" areas from the NPL. Although this project's goals do not include the transfer of federal property to non-federal entities, the process development team aimed to provide a final product with multiple uses. Therefore, the process was developed to meet the requirements of NPL delisting and the transfer of non- contaminated federal lands to future land users. Section 120 (h) of the CERCLA law identifies the requirements for the transfer of federal property that is currently part of an NPL site. Reviews of historical information (including aerial photography), field inspections, and the recorded chain of title documents for the property are required for the delisting of property prior to transfer from the federal government. Despite the widespread availability of remote sensing and other digital geographic data and geographic information systems (GIS) for the analysis of such data, historical aerial photography is the only geographic data source required for review under the CERCLA 120 (h) process. However, since the ORR Environmental Management Program had an established Remote Sensing Program, the Footprint Reduction Project included the development and application of a methodology

  6. High ice water content at low radar reflectivity near deep convection - Part 2: Evaluation of microphysical pathways in updraft parcel simulations

    NASA Astrophysics Data System (ADS)

    Ackerman, A. S.; Fridlind, A. M.; Grandin, A.; Dezitter, F.; Weber, M.; Strapp, J. W.; Korolev, A. V.

    2015-10-01

    The aeronautics industry has established that a threat to aircraft is posed by atmospheric conditions of substantial ice water content (IWC) where equivalent radar reflectivity (Ze) does not exceed 20-30 dBZ and supercooled water is not present; these conditions are encountered almost exclusively in the vicinity of deep convection. Part 1 (Fridlind et al., 2015) of this two-part study presents in situ measurements of such conditions sampled by Airbus in three tropical regions, commonly near 11 km and -43 °C, and concludes that the measured ice particle size distributions are broadly consistent with past literature with profiling radar measurements of Ze and mean Doppler velocity obtained within monsoonal deep convection in one of the regions sampled. In all three regions, the Airbus measurements generally indicate variable IWC that often exceeds 2 g m-3 with relatively uniform mass median area-equivalent diameter (MMDeq) of 200-300 μm. Here we use a parcel model with size-resolved microphysics to investigate microphysical pathways that could lead to such conditions. Our simulations indicate that homogeneous freezing of water drops produces a much smaller ice MMDeq than observed, and occurs only in the absence of hydrometeor gravitational collection for the conditions considered. Development of a mass mode of ice aloft that overlaps with the measurements requires a substantial source of small ice particles at temperatures of about -10 °C or warmer, which subsequently grow from water vapor. One conceivable source in our simulation framework is Hallett-Mossop ice production; another is abundant concentrations of heterogeneous ice freezing nuclei acting together with copious shattering of water drops upon freezing. Regardless of the production mechanism, the dominant mass modal diameter of vapor-grown ice is reduced as the ice-multiplication source strength increases and as competition for water vapor increases. Both mass and modal diameter are reduced by

  7. High ice water content at low radar reflectivity near deep convection - Part 2: Evaluation of microphysical pathways in updraft parcel simulations

    NASA Astrophysics Data System (ADS)

    Ackerman, A. S.; Fridlind, A. M.; Grandin, A.; Dezitter, F.; Weber, M.; Strapp, J. W.; Korolev, A. V.

    2015-06-01

    The aeronautics industry has established that a threat to aircraft is posed by atmospheric conditions of substantial ice water content (IWC) where equivalent radar reflectivity (Ze) does not exceed 20-30 dBZ and supercooled water is not present, encountered almost exclusively in the vicinity of deep convection. Part 1 of this two-part study presents in situ measurements of such conditions sampled by Airbus in three tropical regions, commonly near 11 km and -43 °C, and concludes that the measured ice particle size distributions are broadly consistent with past literature and with profiling radar measurements of Ze and mean Doppler velocity obtained within monsoonal deep convection in one of the regions sampled. In all three regions the Airbus measurements generally indicate variable IWC that often exceeds 2 g m-3 with relatively uniform mass median area-equivalent diameter (MMDeq) of 200-300 μm. Here we use a parcel model with size-resolved microphysics to investigate microphysical pathways that could lead to such conditions. Our simulations indicate that homogeneous freezing of water drops produces a much smaller ice MMDeq than observed, and occurs only in the absence of hydrometeor gravitational collection for the conditions considered. Development of a mass mode of ice aloft that overlaps with the measurements requires a substantial source of small ice particles at temperatures of about -10 °C or warmer, which subsequently grow from water vapor. One conceivable source in our simulation framework is Hallett-Mossop ice production; another is abundant concentrations of heterogeneous ice freezing nuclei acting together with copious shattering of water drops upon freezing. Regardless of production mechanism, the dominant mass modal diameter of vapor-grown ice is reduced as the ice multiplication source strength increases and as competition for water vapor increases. Both mass and modal diameter are reduced by entrainment and by increasing aerosol concentrations

  8. High Ice Water Content at Low Radar Reflectivity near Deep Convection: Part II. Evaluation of Microphysical Pathways in Updraft Parcel Simulations

    NASA Technical Reports Server (NTRS)

    Ackerman, A. S.; Fridlind, A. M.; Grandin, A.; Dezitter, F.; Weber, M.; Strapp, J. W.; Korolev, A. V.

    2015-01-01

    The aeronautics industry has established that a threat to aircraft is posed by atmospheric conditions of substantial ice water content (IWC) where equivalent radar reflectivity (Ze) does not exceed 20-30 dBZ and supercooled water is not present; these conditions are encountered almost exclusively in the vicinity of deep convection. Part 1 (Fridlind et al., 2015) of this two-part study presents in situ measurements of such conditions sampled by Airbus in three tropical regions, commonly near 11 km and -43 C, and concludes that the measured ice particle size distributions are broadly consistent with past literature with profiling radar measurements of Z(sub e) and mean Doppler velocity obtained within monsoonal deep convection in one of the regions sampled. In all three regions, the Airbus measurements generally indicate variable IWC that often exceeds 2 gm (exp -3) with relatively uniform mass median area-equivalent diameter (MMD(sub eq) of 200-300 micrometers. Here we use a parcel model with size-resolved microphysics to investigate microphysical pathways that could lead to such conditions. Our simulations indicate that homogeneous freezing of water drops produces a much smaller ice MMD(sub eq) than observed, and occurs only in the absence of hydrometeor gravitational collection for the conditions considered. Development of a mass mode of ice aloft that overlaps with the measurements requires a substantial source of small ice particles at temperatures of about -10 C or warmer, which subsequently grow from water vapor. One conceivable source in our simulation framework is Hallett-Mossop ice production; another is abundant concentrations of heterogeneous ice freezing nuclei acting together with copious shattering of water drops upon freezing. Regardless of the production mechanism, the dominant mass modal diameter of vapor-grown ice is reduced as the ice-multiplication source strength increases and as competition for water vapor increases. Both mass and modal

  9. Assessing land-use history for reporting on cropland dynamics - A case study using the Land-Parcel Identification System in Ireland

    NASA Astrophysics Data System (ADS)

    Zimmermann, Jesko; González, Ainhoa; Jones, Michael; O'Brien, Phillip; Stout, Jane C.; Green, Stuart

    2016-04-01

    In developed countries, cropland and grassland conversions and management can be a major factor in Land Use and Land Use Change (LULUC) related Greenhouse Gas (GHG) dynamics. Depending on land use, management and factors such as soil properties land can either act as source or sink for GHGs. Currently many countries depend on national statistics combined with socio-economic modelling to assess current land use as well as inter-annual changes. This potentially introduces a bias as it neither provides information on direct land- use change trajectories nor spatially explicit information to assess the environmental context. In order to improve reporting countries are shifting towards high resolution spatial datasets. In this case study, we used the Land Parcel Identification System (LPIS), a pan-European geographical database developed to assist farmers and authorities with agricultural subsidies, to analyse cropland dynamics in Ireland. The database offer high spatial resolution and is updated annually. Generally Ireland is considered grassland dominated with 90 % of its agricultural area under permanent grassland, and only a small area dedicated to cropland. However an in-depth analysis of the LPIS for the years 2000 to 2012 showed strong underlying dynamics. While the annual area reported as cropland remained relatively constant at 3752.3 ± 542.3 km2, the area of permanent cropland was only 1251.9 km2. Reversely, the area that was reported as cropland for at least one year during the timeframe was 7373.4 km2, revealing a significantly higher area with cropland history than annual statistics would suggest. Furthermore, the analysis showed that one quarter of the land converting from or to cropland will return to the previous land use within a year. To demonstrate potential policy impact, we assessed cropland/grassland dynamics from the 2008 to 2012 commitment period using (a) annual statistics, and (b) data including land use history derived from LPIS. Under

  10. A review of modafinil and armodafinil as add-on therapy in antipsychotic-treated patients with schizophrenia

    PubMed Central

    Arends, Johannes; Timmerman, Leo; Lancel, Marike

    2012-01-01

    Schizophrenia is characterized by reality distortion, psychomotor poverty and cognitive disturbances. These characteristics contribute to a lesser social functioning and lower quality of life in patients with schizophrenia. It has been suggested that modafinil and its isomer armodafinil as an add-on strategy to antipsychotic treatment in patients with schizophrenia may improve cognitive functioning, attenuate fatigue, inactiveness and other negative functions as well as weight gain. In this paper we review the literature relevant to the question of whether modafinil and armodafinil are beneficial as add-on therapy in antipsychotic-treated patients with schizophrenia. A total of 15 articles were included in this review; of the 15 articles, 10 were randomized controlled trials (RCTs). Evidence for the use of modafinil or armodafinil as add-on therapy to antipsychotic drugs to alleviate fatigue, sleepiness and inactivity is inconclusive. One cohort study and one out of two single-dose crossover RCTs in which modafinil addition was studied could demonstrate a positive effect. All five RCTs of modafinil (three RCTs) and armodafinil (two RCTs) addition with a longer study duration could not demonstrate a positive effect. With respect to cognitive disturbances, animal models of cognitive deficits show clear improvements with modafinil. In RCTs with a treatment duration of 4 weeks or more, however, no positive effect could be demonstrated on cognitive functioning with modafinil and armodafinil addition. Yet, four single-dose crossover RCTs of modafinil addition show significant positive effects on executive functioning, verbal memory span, visual memory, working memory, spatial planning, slowing in latency, impulse control and recognition of faces expressing sadness and sadness misattribution in the context of disgust recognition. The addition of modafinil or armodafinil to an antipsychotic regime, despite theoretical and preclinical considerations, has not been proved to

  11. A review of modafinil and armodafinil as add-on therapy in antipsychotic-treated patients with schizophrenia.

    PubMed

    Wittkampf, Laura Christina; Arends, Johannes; Timmerman, Leo; Lancel, Marike

    2012-06-01

    Schizophrenia is characterized by reality distortion, psychomotor poverty and cognitive disturbances. These characteristics contribute to a lesser social functioning and lower quality of life in patients with schizophrenia. It has been suggested that modafinil and its isomer armodafinil as an add-on strategy to antipsychotic treatment in patients with schizophrenia may improve cognitive functioning, attenuate fatigue, inactiveness and other negative functions as well as weight gain. In this paper we review the literature relevant to the question of whether modafinil and armodafinil are beneficial as add-on therapy in antipsychotic-treated patients with schizophrenia. A total of 15 articles were included in this review; of the 15 articles, 10 were randomized controlled trials (RCTs). Evidence for the use of modafinil or armodafinil as add-on therapy to antipsychotic drugs to alleviate fatigue, sleepiness and inactivity is inconclusive. One cohort study and one out of two single-dose crossover RCTs in which modafinil addition was studied could demonstrate a positive effect. All five RCTs of modafinil (three RCTs) and armodafinil (two RCTs) addition with a longer study duration could not demonstrate a positive effect. With respect to cognitive disturbances, animal models of cognitive deficits show clear improvements with modafinil. In RCTs with a treatment duration of 4 weeks or more, however, no positive effect could be demonstrated on cognitive functioning with modafinil and armodafinil addition. Yet, four single-dose crossover RCTs of modafinil addition show significant positive effects on executive functioning, verbal memory span, visual memory, working memory, spatial planning, slowing in latency, impulse control and recognition of faces expressing sadness and sadness misattribution in the context of disgust recognition. The addition of modafinil or armodafinil to an antipsychotic regime, despite theoretical and preclinical considerations, has not been proved to

  12. Alirocumab as Add-On to Atorvastatin Versus Other Lipid Treatment Strategies: ODYSSEY OPTIONS I Randomized Trial

    PubMed Central

    Gaudet, Daniel; Weiss, Robert; Ruiz, Juan Lima; Watts, Gerald F.; Gouni-Berthold, Ioanna; Robinson, Jennifer; Zhao, Jian; Hanotin, Corinne; Donahue, Stephen

    2015-01-01

    Context: Despite current standard of care, many patients at high risk of cardiovascular disease (CVD) still have elevated low-density lipoprotein cholesterol (LDL-C) levels. Alirocumab is a fully human monoclonal antibody inhibitor of proprotein convertase subtilisin/kexin type 9. Objective: The objective of the study was to compare the LDL-C-lowering efficacy of adding alirocumab vs other common lipid-lowering strategies. Design, Patients, and Interventions: Patients (n = 355) with very high CVD risk and LDL-C levels of 70 mg/dL or greater or high CVD risk and LDL-C of 100 mg/dL or greater on baseline atorvastatin 20 or 40 mg were randomized to one of the following: 1) add-on alirocumab 75 mg every 2 weeks (Q2W) sc; 2) add-on ezetimibe 10 mg/d; 3) double atorvastatin dose; or 4) for atorvastatin 40 mg regimen only, switch to rosuvastatin 40 mg. For patients not achieving protocol-defined LDL-C goals, the alirocumab dose was increased (blinded) at week 12 to 150 mg Q2W. Main Outcome Measure: The primary end point was percentage change in calculated LDL-C from baseline to 24 weeks (intent to treat). Results: Among atorvastatin 20 and 40 mg regimens, respectively, add-on alirocumab reduced LDL-C levels by 44.1% and 54.0% (P < .001 vs all comparators); add-on ezetimibe, 20.5% and 22.6%; doubling of atorvastatin dose, 5.0% and 4.8%; and switching atorvastatin 40 mg to rosuvastatin 40 mg, 21.4%. Most alirocumab-treated patients (87.2% and 84.6%) achieved their LDL-C goals. Most alirocumab-treated patients (86%) maintained their 75-mg Q2W regimen. Treatment-emergent adverse events occurred in 65.4% of alirocumab patients vs 64.4% ezetimibe and 63.8% double atorvastatin/switch to rosuvastatin (data were pooled). Conclusions: Adding alirocumab to atorvastatin provided significantly greater LDL-C reductions vs adding ezetimibe, doubling atorvastatin dose, or switching to rosuvastatin and enabled greater LDL-C goal achievement. PMID:26030325

  13. Monolithically integrated 20-channel optical add/drop multiplexer subsystem with hybrid-integrated 40-channel photodetector array

    NASA Astrophysics Data System (ADS)

    Schumacher, Andreas B.; Krabe, Detlef; Dieckroeger, Jens; Spott, Thorsten; Kraeker, Tobias; Martins, Evely; Zavrsnik, Miha; Schneider, Hartmut W.; Baumann, Ingo

    2003-03-01

    We built a 20 channel, 200 GHz, fully reconfigurable optical add-/drop multiplexer with integrated variable optical attenuators and power monitor diodes. A single planar lightwave circuit chip contains demultiplexer, switch array, attenuators and multiplexers. It also serves as an "optical motherboard" for a hybrid, flip-chip assembly containing four 10-channel photo detector arrays. A thermal management concept which considers both microscopic and macroscopic aspects of the device was developed. The final device exhibits an insertion loss of 9 dB from "in"- to "through"-port, a 1 dB bandwidth of >50 GHz and switch extinction ratios in excess of 40 dB.

  14. ADD66, a Gene Involved in the Endoplasmic Reticulum-associated Degradation of α-1-Antitrypsin-Z in Yeast, Facilitates Proteasome Activity and Assembly

    PubMed Central

    Scott, Craig M.; Kruse, Kristina B.; Schmidt, Béla Z.; Perlmutter, David H.; McCracken, Ardythe A.

    2007-01-01

    Antitrypsin deficiency is a primary cause of juvenile liver disease, and it arises from expression of the “Z” variant of the α-1 protease inhibitor (A1Pi). Whereas A1Pi is secreted from the liver, A1PiZ is retrotranslocated from the endoplasmic reticulum (ER) and degraded by the proteasome, an event that may offset liver damage. To better define the mechanism of A1PiZ degradation, a yeast expression system was developed previously, and a gene, ADD66, was identified that facilitates A1PiZ turnover. We report here that ADD66 encodes an ∼30-kDa soluble, cytosolic protein and that the chymotrypsin-like activity of the proteasome is reduced in add66Δ mutants. This reduction in activity may arise from the accumulation of 20S proteasome assembly intermediates or from qualitative differences in assembled proteasomes. Add66p also seems to be a proteasome substrate. Consistent with its role in ER-associated degradation (ERAD), synthetic interactions are observed between the genes encoding Add66p and Ire1p, a transducer of the unfolded protein response, and yeast deleted for both ADD66 and/or IRE1 accumulate polyubiquitinated proteins. These data identify Add66p as a proteasome assembly chaperone (PAC), and they provide the first link between PAC activity and ERAD. PMID:17634286

  15. [Natural selection].

    PubMed

    Mayr, E

    1985-05-01

    Much of the resistance against Darwin's theory of natural selection has been due to misunderstandings. It is shown that natural selection is not a tautology and that it is a two-step process. The first step, the production of variation, is under the control of chance; the second step, selection proper, is an anti-chance process, but subject to many constraints. The target of selection is the individual as a whole, and many neutral mutations can be retained as hitchhikers of successful genotypes. Sexual selection results from selection for pure reproductive success.

  16. Values clarification in a decision aid about fertility preservation: does it add to information provision?

    PubMed Central

    2014-01-01

    Background We aimed to evaluate the effect of a decision aid (DA) with information only compared to a DA with values clarification exercise (VCE), and to study the role of personality and information seeking style in DA-use, decisional conflict (DC) and knowledge. Methods Two scenario-based experiments were conducted with two different groups of healthy female participants. Dependent measures were: DC, knowledge, and DA-use (time spent, pages viewed, VCE used). Respondents were randomized between a DA with information only (VCE-) and a DA with information plus a VCE(VCE+) (experiment 1), or between information only (VCE-), information plus VCE without referral to VCE(VCE+), and information plus a VCE with specific referral to the VCE, requesting participants to use the VCE(VCE++) (experiment 2). In experiment 2 we additionally measured personality (neuroticism/conscientiousness) and information seeking style (monitoring/blunting). Results Experiment 1. There were no differences in DC, knowledge or DA-use between VCE- (n=70) and VCE+ (n=70). Both DAs lead to a mean gain in knowledge from 39% at baseline to 73% after viewing the DA. Within VCE+, VCE-users (n=32, 46%) reported less DC compared to non-users. Since there was no difference in DC between VCE- and VCE+, this is likely an effect of VCE-use in a self-selected group, and not of the VCE per se. Experiment 2. There were no differences in DC or knowledge between VCE- (n=65), VCE+ (n=66), VCE++ (n=66). In all groups, knowledge increased on average from 42% at baseline to 72% after viewing the DA. Blunters viewed fewer DA-pages (R=0.38, p<.001). More neurotic women were less certain (R=0.18, p<.01) and felt less supported in decision making (R=0.15, p<.05); conscientious women felt more certain (R=-0.15, p<.05) and had more knowledge after viewing the DA (R=0.15, p<.05). Conclusions Both DAs lead to increased knowledge in healthy populations making hypothetical decisions, and use of the VCE did not improve

  17. Antidiabetic Effects of Add-On Gynostemma pentaphyllum Extract Therapy with Sulfonylureas in Type 2 Diabetic Patients

    PubMed Central

    Huyen, V. T. T.; Phan, D. V.; Thang, P.; Ky, P. T.; Hoa, N. K.; Ostenson, C. G.

    2012-01-01

    Aims. To investigate the antidiabetic effect of the traditional Vietnamese herb Gynostemma pentaphyllum (GP) together with sulfonylurea (SU) in 25 drug-naïve type 2 diabetic patients. Methods. After 4-week treatment with gliclazide (SU), 30 mg daily, all patients were randomly assigned into 2 groups to add on GP extract or placebo extract, 6 g daily, during eight weeks. Results. After 4-week SU treatment, fasting plasma glucose (FPG) and HbA1C decreased significantly (P < 0.001). FPG was further reduced after add-on therapy with 2.9 ± 1.7 and 0.9 ± 0.6 mmol/L in the GP and placebo groups, respectively (P < 0.001). Therapy with GP extract also reduced 30- and 120-minute oral glucose tolerance test postload values. HbA1C levels decreased approximately 2% units in the GP group compared to 0.7% unit in the placebo group (P < 0.001). Conclusion. GP extract in addition to SU offers an alternative to addition of other oral medication to treat type 2 diabetic patients. PMID:23125867

  18. A delay-and-Boolean-ADD imaging algorithm for damage detection with a small number of piezoceramic transducers

    NASA Astrophysics Data System (ADS)

    Lu, Guangtao; Li, Yourong; Song, Gangbing

    2016-09-01

    The delay-and-sum (DAS) imaging algorithm usually sends an excitation signal at each piezoceramic transducer and obtains a defect image by using transmitter-sensor pair signals to draw ellipses or hyperbolas. A delay-and-Boolean-ADD (DABA) imaging algorithm is developed for defect detection of plate-like structures with a small number of piezoceramic transducers. This new method requires sending only one excitation signal for each detection, and obtains a better defect image by employing Boolean ADD operation instead of addition or multiplication operation in the DAS algorithm. A reflection coefficient is introduced in the new algorithm to attenuate the signals reflected from the boundary. The widely used envelop-detection method based on Hilbert-transformation is replaced by a new envelop-detection technique based on a local maximum value to increase the accuracy of locating. An additional time shift due to the excitation signal itself is also considered to decrease the location error. The results of the experiments conducted on an aluminum plate indicate that the proposed DABA imaging algorithm combining with the new techniques can detect a bonded mass defect accurately and efficiently.

  19. Impact of maternal and paternal preconception health on birth outcomes using prospective couples’ data in Add Health

    PubMed Central

    Moss, Jennifer L.; Harris, Kathleen Mullan

    2014-01-01

    Purpose Retrospective studies of preconception health have demonstrated that parents’ health conditions and behaviors can impact a newborn’s birth outcomes and, subsequently, future health status. This study sought to examine the impact of preconception health, measured prospectively, among both mothers and fathers, on two important birth outcomes: birthweight and gestational age. Methods Data came from Add Health (the National Longitudinal Study of Adolescent Health), which included interviews with original participants and a subsample of their partners in 2001–02. In 2008, the original respondents again completed an interview for Add Health. For 372 eligible infants born to these couples, birth outcomes (measured in 2008) were regressed on preconception health conditions and behaviors among non-pregnant heterosexual partners (measured in 2001–02). Results Mean birthweight was 3399 grams, and mean gestational age was 39 weeks. Birthweight was higher for infants born to mothers with diabetes or high blood pressure, and for mothers who drank alcohol at least once per month, and lower for infants born to fathers with diabetes (p < .05). Infant gestational age was marginally lower for infants born to mothers with higher levels of depression (p < .10), and lower for infants born to fathers with diabetes and with higher levels of fast food consumption (p < .05). Conclusions Both maternal and paternal preconception health conditions and behaviors influenced infant birth outcomes. Interventions to promote preconception health should focus on prevention of diabetes and high blood pressure, as well as minimizing consumption of alcohol and fast food. PMID:25367598

  20. Analysis of the add-on effect of α-glucosidase inhibitor, acarbose in insulin therapy: A pilot study

    PubMed Central

    Li, Feng-Fei; Fu, Li-Yuan; Xu, Xiao-Hua; Su, Xiao-Fei; Wu, Jin-Dan; Ye, Lei; Ma, Jian-Hua

    2016-01-01

    The aim of the present study was to evaluate the add-on effect of acarbose therapy in oxidative stress, and the lipid and inflammatory profiles of patients with type 2 diabetes mellitus (T2DM) treated with insulin. This was an open and unblended study. Patients (n=134) with T2DM (haemoglobin A1c range, 9.0–12.0%) were recruited. After continuous subcutaneous insulin infusion for 7 days for initial rapid correction of hyperglycaemia, a premixed insulin titration period (duration, 4–6 days) subsequently followed. Patients were then randomized (1:1) into two groups as follows: An acarbose plus pre-mixed 30/70 insulin group or a pre-mixed 30/70 insulin only group; each group received treatment for 2 weeks. Plasma high-sensitivity C-reactive protein (Hs-CRP), 8-iso-prostaglandin F2α (8-iso PGF2α), tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6 levels were measured before and after therapy. Patients that received acarbose plus insulin demonstrated greater reduction in 8-iso PGF2α, Hs-CRP, TNF-α, IL-1β and IL-6 levels when compared with the insulin only patients. Thus, acarbose add-on insulin therapy was identified to be associated with greater improvements in oxidative stress and inflammation in patients with T2DM when compared with those that received insulin only therapy.

  1. A delay-and-Boolean-ADD imaging algorithm for damage detection with a small number of piezoceramic transducers

    NASA Astrophysics Data System (ADS)

    Lu, Guangtao; Li, Yourong; Song, Gangbing

    2016-09-01

    The delay-and-sum (DAS) imaging algorithm usually sends an excitation signal at each piezoceramic transducer and obtains a defect image by using transmitter–sensor pair signals to draw ellipses or hyperbolas. A delay-and-Boolean-ADD (DABA) imaging algorithm is developed for defect detection of plate-like structures with a small number of piezoceramic transducers. This new method requires sending only one excitation signal for each detection, and obtains a better defect image by employing Boolean ADD operation instead of addition or multiplication operation in the DAS algorithm. A reflection coefficient is introduced in the new algorithm to attenuate the signals reflected from the boundary. The widely used envelop-detection method based on Hilbert-transformation is replaced by a new envelop-detection technique based on a local maximum value to increase the accuracy of locating. An additional time shift due to the excitation signal itself is also considered to decrease the location error. The results of the experiments conducted on an aluminum plate indicate that the proposed DABA imaging algorithm combining with the new techniques can detect a bonded mass defect accurately and efficiently.

  2. Treatment of Endometriosis with the GnRHa Deslorelin and Add-Back Estradiol and Supplementary Testosterone

    PubMed Central

    Agarwal, Sanjay K.; Daniels, AnnaMarie; Drosman, Steven R.; Udoff, Laurence; Foster, Warren G.; Pike, Malcolm C.; Spicer, Darcy V.; Daniels, John R.

    2015-01-01

    Background. This randomized, multicenter, open-label clinical trial was intended to generate pilot data on the efficacy and safety of the gonadotropin-releasing hormone agonist (GnRHa) deslorelin (D) with low-dose estradiol ± testosterone (E2  ± T) add-back for endometriosis-related pelvic pain. Methods. Women with pelvic pain and laparoscopically confirmed endometriosis were treated with a six-month course of daily intranasal D with concurrent administration of either transdermal E2, intranasal E2, or intranasal E2  + T. Efficacy data included evaluation of dyspareunia, dysmenorrhea, pelvic pain, tenderness, and induration. Cognition and quality of life were also assessed. Safety parameters included assessment of endometrial hyperplasia, bone mineral density (BMD), and hot flashes. Results. Endometriosis symptoms and signs scores decreased in all treatment arms from a baseline average of 7.4 to 2.5 after 3 months of treatment and 3.4 after 6 months. BMD changes and incidence of hot flashes were minimal, and no endometrial hyperplasia was observed. Patient-reported outcomes showed significant improvement across multiple domains. Conclusions. Daily intranasal D with low dose E2  ± T add-back resulted in significant reduction in severity of endometriosis symptoms and signs with few safety signals and minimal hypoestrogenic symptoms that would be expected with the use of a GnRHa alone. PMID:26881208

  3. Feasibility study of veterinary antibiotic consumption in Germany - comparison of ADDs and UDDs by animal production type, antimicrobial class and indication

    PubMed Central

    2014-01-01

    Background Within a feasibility study the use of antibiotics in pigs and cattle was determined in 24 veterinary practices in Lower Saxony and on 66 farms in North Rhine-Westphalia in Germany. Focus was laid on the comparison of the Used Daily Doses (UDD) (dose per animal and day prescribed by the veterinarians) with the Defined Animal Daily Doses (ADD) (dose per animal and day calculated by means of recommended dosages and estimated live weights). Results For piglets and calves most of the UDD (50% and 46% of nUDD, respectively) were above the ADD (i.e. UDD/ADD-ratio above 1.25). Regarding sows, fattening pigs, dairy and beef cattle, most of the UDDs (49% to 65% of nUDD) were lower than the respective ADD (i.e. UDD/ADD-ratio below 0.8). In pigs, the UDDs of beta-lactams, fluoroquinolones and cephalosporins, and in cattle, those of macrolides and beta-lactams were often below the ADDs. Tetracyclines were frequently used above the recommended dose. Enteric diseases were more often treated below the recommended dose than respiratory diseases, possibly due to overestimation of the live weight (diarrhea in young animals, respiratory diseases in elder animals) and consequently overestimation of the recommended dose. Conclusion Comparisons between UDD and ADD can be used to observe differences between antimicrobials and trends in the usage of antibiotics. But individual treatment comparisons of UDD and ADD must be interpreted carefully, because they may be due to lower live weights than estimated. Correlating such data with data on the occurrence of resistant bacteria in future may help to improve resistance prevention and control. PMID:24401194

  4. Globes from global data: Charting international research networks with the GRASS GIS r.out.polycones add-on module.

    NASA Astrophysics Data System (ADS)

    Löwe, Peter

    2015-04-01

    Many Free and Open Source Software (FOSS) tools have been created for the various application fields within geoscience. While FOSS allows re-implementation of functionalities in new environments by access to the original codebase, the easiest approach to build new software solutions for new problems is the combination or merging of existing software tools. Such mash-ups are implemented by embedding and encapsulating FOSS tools within each another, effectively focusing the use of the embedded software to the specific role it needs to perform in the given scenario, while ignoring all its other capabilities. GRASS GIS is a powerful and established FOSS GIS for raster, vector and volume data processing while the Generic Mapping Tools (GMT) are a suite of powerful Open Source mapping tools, which exceed the mapping capabilities of GRASS GIS. This poster reports on the new GRASS GIS add-on module r.out.polycones. It enables users to utilize non-continuous projections for map production within the GRASS production environment. This is implemented on the software level by encapsulating a subset of GMT mapping capabilities into a GRASS GIS (Version 6.x) add-on module. The module was developed at the German National Library of Science and Technology (TIB) to provide custom global maps of scientific collaboration networks, such as the DataCite consortium, the registration agency for Digital Object Identifiers (DOI) for research data. The GRASS GIS add-on module can be used for global mapping of raster data into a variety of non continuous sinosoidal projections, allowing the creation of printable biangles (gores) to be used for globe making. Due to the well structured modular nature of GRASS modules, technical follow-up work will focus on API-level Python-based integration in GRASS 7 [1]. Based on this, GMT based mapping capabilities in GRASS will be extended beyond non-continuous sinosoidal maps and advanced from raster-layers to content GRASS display monitors. References

  5. Laboratory tests on an aircraft fuselage to determine the insertion loss of various acoustic add-on treatments

    NASA Technical Reports Server (NTRS)

    Heitman, K. E.; Mixson, J. S.

    1984-01-01

    This paper describes a laboratory study of add-on acoustic treatments for a propeller-driven light aircraft fuselage. The treatments included: no treatment (i.e., baseline fuselage); a production-type double-wall interior; and various amounts of high density fiberglass added to the baseline fuselage. The sound source was a pneumatic-driver with attached exponential horn, supplied with a broadband signal. Data were acquired at the approximate head positions of the six passenger seats. The results were analyzed on space-averaged narrowband, one-third octave band and overall insertion loss basis. In addition, insertion loss results for the different configurations at specific frequencies representing propeller tone spectra are presented. The propeller tone data includes not only the space-averaged insertion loss, but also the variation of insertion loss at these particular frequencies across the six microphone positions.

  6. Performance Optimization of 45-Channel Superdense Wavelength-Division-Multiplexed (SDWDM) Optical Add-Drop Multiplexer (OADM) Ring Network

    NASA Astrophysics Data System (ADS)

    Sharma, Vikrant; Sharma, Anurag; Kaur, Dalvir

    2015-06-01

    In this paper, performance analysis of high-speed superdense wavelength-division-multiplexing (SDWDM) optical add-drop multiplexer (OADM) optical ring network for 6 nodes, 45 wavelengths having channel spacing of 0.2 nm on 300 km unidirectional nonlinear single-mode fiber ring of 10 Gbit/s has been reported. The performance optimization of the system by comparing different modulation formats has been reported on the basis of eye diagram and bit error rate (BER). It has been reported that CSRZ modulation format can achieve BER as better as e-24, which gives best performance. This paper also presents a study of performance degradation caused by the crosstalk and the effect of channel spacing on SWDM system.

  7. Modifications made to ModelMuse to add support for the Saturated-Unsaturated Transport model (SUTRA)

    USGS Publications Warehouse

    Winston, Richard B.

    2014-01-01

    This report (1) describes modifications to ModelMuse,as described in U.S. Geological Survey (USGS) Techniques and Methods (TM) 6–A29 (Winston, 2009), to add support for the Saturated-Unsaturated Transport model (SUTRA) (Voss and Provost, 2002; version of September 22, 2010) and (2) supplements USGS TM 6–A29. Modifications include changes to the main ModelMuse window where the model is designed, addition of methods for generating a finite-element mesh suitable for SUTRA, defining how some functions shouldapply when using a finite-element mesh rather than a finite-difference grid (as originally programmed in ModelMuse), and applying spatial interpolation to angles. In addition, the report describes ways of handling objects on the front view of the model and displaying data. A tabulation contains a summary of the new or modified dialog boxes.

  8. Parametric study of dielectric loaded surface plasmon polariton add-drop filters for hybrid silicon/plasmonic optical circuitry

    NASA Astrophysics Data System (ADS)

    Dereux, A.; Hassan, K.; Weeber, J.-C.; Djellali, N.; Bozhevolnyi, S. I.; Tsilipakos, O.; Pitilakis, A.; Kriezis, E.; Papaioannou, S.; Vyrsokinos, K.; Pleros, N.; Tekin, T.; Baus, M.; Kalavrouziotis, D.; Giannoulis, G.; Avramopoulos, H.

    2011-01-01

    Surface plasmons polaritons are electromagnetic waves propagating along the surface of a conductor. Surface plasmons photonics is a promising candidate to satisfy the constraints of miniaturization of optical interconnects. This contribution reviews an experimental parametric study of dielectric loaded surface plasmon waveguides ring resonators and add-drop filters within the perspective of the recently suggested hybrid technology merging plasmonic and silicon photonics on a single board (European FP7 project PLATON "Merging Plasmonic and Silicon Photonics Technology towards Tb/s routing in optical interconnects"). Conclusions relevant for dielectric loaded surface plasmon switches to be integrated in silicon photonic circuitry will be drawn. They rely on the opportunity offered by plasmonic circuitry to carry optical signals and electric currents through the same thin metal circuitry. The heating of the dielectric loading by the electric current enables to design low foot-print thermo-optical switches driving the optical signal flow.

  9. The Effects of Pycnogenol® as Add-on Drug to Metformin Therapy in Diabetic Rats.

    PubMed

    Jankyova, Stanislava; Rubintova, Dominika; Janosikova, Lenka; Panek, Peter; Foltanova, Tatiana; Kralova, Eva

    2016-08-01

    The progression of diabetes mellitus leads in time to the development of serious cardiovascular complications. Pycnogenol® (PYC) belongs to strong antioxidants that may interfere with different pathways playing an important role in diseases associated with oxidative stress. Metformin (MET), commonly used antidiabetic drug, has cardio-protective effects via activation of AMP kinase (AMPK). In our study, we examined the effects of PYC as add-on drug to metformin therapy in streptozotocin (STZ)-induced diabetic rats. Our results revealed that both used agents, PYC and MET, showed improvement of blood glucose levels, vascular reactivity, left ventricular hypertrophy, expression of AMPK, glucose transporter 4 (GLUT4) and calcium/calmodulin-dependent protein kinase II (CaMKII) in left ventricle of the hearts. However, the combination of these interventions has failed to possess higher efficacy. Copyright © 2016 John Wiley & Sons, Ltd. PMID:27170051

  10. Flexible Filter Bank Based on an Improved Weighted Overlap-Add Algorithm for Processing Wide Bandwidth Radio Astronomy Signals

    NASA Astrophysics Data System (ADS)

    Wang, Xianhai; Meng, Qiao; Han, J. L.; Liu, Wei; Zhang, Jianwei

    2015-12-01

    Wideband signals from a radio telescope have to be channelized for spectral observations or for dedispersion for pulsar observations. A polyphase filter bank is designed based on the improved weighted overlap-add (IWOLA) algorithm to achieve channelization. The IWOLA algorithm involves applying an equivalent Hilbert transform to the normal WOLA filter bank by shifting the center frequency of every sub-band by a half of the frequency bin, so that the IWOLA filter bank provides K independently output complex subbands instead of the usual K + 1 sub-bands, reducing the subsequent processing units by one set. Performance of the proposed IWOLA filter bank is analyzed by means of MATLAB simulations. We show how the IWOLA filter bank can be used for a two-stage, high-resolution spectrometer, with a much reduced consumption of FPGA on-chip block RAM.

  11. Sexual selection.

    PubMed

    Hosken, David J; House, Clarissa M

    2011-01-25

    Sexual selection is a concept that has probably been misunderstood and misrepresented more than any other idea in evolutionary biology, confusion that continues to the present day. We are not entirely sure why this is, but sexual politics seems to have played its role, as does a failure to understand what sexual selection is and why it was initially invoked. While in some ways less intuitive than natural selection, sexual selection is conceptually identical to it, and evolution via either mechanism will occur given sufficient genetic variation. Recent claims that sexual selection theory is fundamentally flawed are simply wrong and ignore an enormous body of evidence that provides a bedrock of support for this major mechanism of organic evolution. In fact it is partly due to this solid foundation that current research has largely shifted from documenting whether or not sexual selection occurs, to addressing more complex evolutionary questions. PMID:21256434

  12. Treatment of infectious waste: development and testing of an add-on set for used gravity displacement autoclaves.

    PubMed

    Stolze, René; Kühling, Jan-Gerd

    2009-06-01

    The safe management of potentially infectious healthcare waste is gaining increasing worldwide importance. In developing countries, simple incinerators are used for the treatment of this type of waste stream. However, as these incinerators produce high emissions and represent the main generators of dioxin and furans in these countries, alternative and cost-effective solutions are needed. As steam treatment systems do not produce persistent organic pollutants, the use of existing (older) medical autoclaves could represent a solution for the treatment of infectious waste. ETLog Health EnviroTech & Logistics, the German-based consulting and engineering company carried out the first research into whether gravity air displacement autoclaves can be used for the safe decontamination of infectious waste. The research showed that it is not possible to decontaminate waste using this type of autoclave. A subsequent research and development phase might, however, make it possible to develop a new process cycle. Tests carried out on the basis of international standards and norms showed that by applying this process cycle and using an add-on set, it is possible to treat healthcare waste using the existing stock of older medical autoclaves. The process cycle and the add-on set developed were tested under existing conditions in Hanoi, Vietnam using the treatment cycle developed for a 13-year-old autoclave. All the parameters for infectious waste decontamination were reached. As modified autoclaves prevent the emission of toxic substances, this approach presents an interim solution, which avoids the impacts on human health and the environment caused by the incineration of healthcare waste.

  13. Effects of minocycline add-on treatment on brain morphometry and cerebral perfusion in recent-onset schizophrenia.

    PubMed

    Chaves, Cristiano; Marque, Cristiane R; Maia-de-Oliveira, João P; Wichert-Ana, Lauro; Ferrari, Thiago B; Santos, Antonio C; Araújo, David; Machado-de-Sousa, João P; Bressan, Rodrigo A; Elkis, Helio; Crippa, José A; Guimarães, Francisco S; Zuardi, Antônio W; Baker, Glen B; Dursun, Serdar M; Hallak, Jaime E C

    2015-02-01

    Increasing evidence suggests that the tetracycline antibiotic minocycline has neuroprotective effects and is a potential treatment for schizophrenia. However, the mechanisms of action of minocycline in the CNS remain elusive. The aim of this study was to investigate the effects of minocycline on brain morphology and cerebral perfusion in patients with recent-onset schizophrenia after 12months of a randomized double-blind, placebo-controlled clinical trial of minocycline add-on treatment. This study included 24 outpatients with recent-onset schizophrenia randomized for 12months of adjuvant treatment with minocycline (200mg/d) or placebo. MRI (1.5T) and [(99m)Tc]-ECD SPECT brain scans were performed at the end of the 12-month of trial. Between-condition comparisons of SPECT and MRI brain images were performed using statistical parametric mapping and analyzed by voxel-based morphometry (VBM). Minocycline adjuvant treatment significantly reduced positive and negative symptoms when compared with placebo. The VBM analysis of MRI scans showed that the patients in the placebo group had significant lower gray matter volumes in the midposterior cingulate cortex and in the precentral gyrus in comparison with the patients in the minocycline group. In addition, a decreased ECD uptake in the minocycline condition was observed in fronto-temporal areas. These results suggest that minocycline may protect against gray matter loss and modulate fronto-temporal areas involved in the pathophysiology of schizophrenia. Furthermore, minocycline add-on treatment may be a potential treatment in the early stages of schizophrenia and may ameliorate clinical deterioration and brain alterations observed in this period.

  14. Run-time Ink Stability in Pneumatic Aerosol Jet Printing Using a Split Stream Solvent Add Back System

    NASA Astrophysics Data System (ADS)

    Wadhwa, Arjun

    Aerosol Jet printing is a non-contact process capable of printing nano-ink patterns on conformal and flexible surfaces. Aqueous or solvent nano-inks are pneumatically atomized by the flow of nitrogen gas. The flow of atomizing gas into and out of the cup leads to evaporation and removal of volatile solvent(s). As the solid loading fraction of the ink increases, the rheological changes eventually lead to instabilities in print output. A potential solution to this problem is to moisten the atomizing ink by running it through a bubbler. In this study, neat co-solvent solutions of ethanol and ethylene glycol at 85: 15 and 30:70 mixing ratios were atomized using nitrogen flow rates ranging from 600 to 1000 ccm. It was observed that ethanol, being the more volatile solvent, was depleted from the neat solution. When using a bubbler solvent add-back system, an excessive amount of ethanol was returned to the neat solution. The rate of solvent loss from an ethanol rich neat solution (80%) was higher compared to an ethylene glycol rich neat solution. A mixture of dry and wet (ethanol moistened) nitrogen gas was used to equalize the rate of ethanol evaporation. Ethanol equilibrium in neat solutions with higher ethylene glycol loading (70%) was achieved with a 40-60% wet nitrogen component while neat solutions with higher ethanol loading (85%) were stable with 85 -90% wet nitrogen gas. The results were validated with copper nano ink with similar co-solvent ratios. The solid content of the ink remained constant over four hours of printing when the optimal dry: wet nitrogen gas ratios were used. Copper ink with 85% ethanol being atomized at 1000 ccm exhibited increase in copper loading (3%) despite the dry: wet solvent add back system.

  15. Selecting Software.

    ERIC Educational Resources Information Center

    Pereus, Steven C.

    2002-01-01

    Describes a comprehensive computer software selection and evaluation process, including documenting district needs, evaluating software packages, weighing the alternatives, and making the purchase. (PKP)

  16. Lithium as add-on to quetiapine XR in adult patients with acute mania: a 6-week, multicenter, double-blind, randomized, placebo-controlled study.

    PubMed

    Bourin, Michel S; Severus, Emanuel; Schronen, Juan P; Gass, Peter; Szamosi, Johan; Eriksson, Hans; Chandrashekar, Hongally

    2014-01-01

    Quetiapine extended release (XR) and lithium are treatments with proven efficacy in acute mania. This randomized study evaluated the efficacy and safety of lithium or placebo as add-on to quetiapine XR in adult patients with manic or mixed symptoms of bipolar I disorder. In this 6-week, double-blind study (Trial D144AC00003), adult patients with DSM-IV-TR-diagnosed bipolar I disorder (current episode manic or mixed), a Young Mania Rating Scale (YMRS) total score ≥20, and score ≥4 on two of four core YMRS items were administered quetiapine XR (400 to 800 mg/day) and randomly assigned to receive add-on lithium (600 to 1,800 mg/day) or placebo. The primary efficacy end point was change in the YMRS total score from baseline to day 43, analyzed using a mixed-model for repeated measures (MMRM) approach. Secondary efficacy and safety end points were also measured. Rating scales were administered by trained staff. Three hundred fifty-six patients treated with quetiapine XR were randomized to add-on lithium (n = 173) or placebo (n = 183). Two hundred ninety-one patients (81.7%) completed the study. At day 43, least squares mean change in YMRS total score was -22.8 for add-on lithium and -20.1 for add-on placebo, a statistically significant treatment group difference of -2.69 (p < 0.001). On secondary measures, add-on lithium was associated with significant improvements in response, remission, illness severity, and overall illness versus add-on placebo (p < 0.05). The number needed to treat was 9.1 for response and 7.9 for remission for add-on lithium compared with add-on placebo. Lithium in combination with quetiapine XR was generally well tolerated, with a similar profile to quetiapine XR in combination with placebo. The addition of lithium to quetiapine XR therapy was associated with significantly greater efficacy than placebo as add-on and was generally well tolerated in patients with acute bipolar I mania. This study was registered under Clinicaltrials

  17. The effect of add-on memantine on global function and quality of life in schizophrenia: A randomized, double-blind, controlled, clinical trial

    PubMed Central

    Omranifard, Victoria; Rajabi, Fatemeh; Mohammadian-Sichani, Maryam; Maracy, Mohammad

    2015-01-01

    Background: Schizophrenia severely influences function and quality of life. The benefit of newer antipsychotics in improving the quality of life in schizophrenia still remains controversial. The aim of the present study is to evaluate the effect of memantine on global function and quality of life in patients with schizophrenia. Materials and Methods: This was a randomized controlled trial on inpatient cases of schizophrenia in Noor University Hospital, Isfahan, Iran. A number of 64 patients were selected through sequential sampling; patients were randomly allocated in intervention and placebo groups. The intervention group was treated with memantine plus previously administered, stabled-dose, atypical antipsychotic, while the control group received placebo plus previously administered, stabled-dose, atypical antipsychotic. Memantine administration was initiated at 5 mg daily; the dosage was increased at weekly intervals by 5 mg and finally up-titrated to 20 mg daily within 4 weeks. All patients were assessed by means of Global Assessment of Functioning (GAF) and quality of life scale (QLS) initially and every four weeks to the end of the 12th week. Results: Analysis of baseline GAF and QLS scores showed no significant differences between the two groups (P = 0.081 and P = 0.225, respectively). GAF and QLS scores increased in both groups; but it was higher in the intervention group. The difference between the two groups was statistically significant. (P < 0.001 and P < 0.001, respectively) memantine was well tolerated, with no significant side effects. Conclusion: Add-on memantine was significantly effective in improving the global function of patients as well as their quality of life. PMID:26605240

  18. Concept for On-Board Safe Landing Target Selection and Landing for the Mars 2020 Mission

    NASA Astrophysics Data System (ADS)

    Brugarolas, P.; Chen, A.; Johnson, A.; Casoliva, J.; Singh, G.; Stehura, A.; Way, D.; Dutta, S.

    2014-06-01

    We present a concept for a potential enhancement to Mars 2020 to enable landing on hazardous landing sites. It adds to MSL-EDL the capability to select and divert to a safe site through on-board terrain relative localization and target selection.

  19. Characterization of Disopyramide derivative ADD424042 as a non-cardiotoxic neuronal sodium channel blocker with broad-spectrum anticonvulsant activity in rodent seizure models.

    PubMed

    Król, Marek; Ufnal, Marcin; Szulczyk, Bartłomiej; Podsadni, Piotr; Drapała, Adrian; Turło, Jadwiga; Dawidowski, Maciej

    2016-01-01

    It was reported that antiarrhythmic drugs (AADs) can be useful in controlling refractory seizures in humans or in enhancing the action of antiepileptic drugs (AEDs) in animal models. Disopyramide phosphate (DISO) is an AAD that blocks sodium channels in cardiac myocytes. We evaluated a DISO derivative, 2-(2-chlorophenyl)-2-(pyridin-2-yl)acetamide (ADD424042) for its anticonvulsant activity in a battery of rodent models of epileptic seizures. The compound displayed a broad spectrum of activity in the 'classical' models as well as in the models of pharmacoresistant seizures. Furthermore, ADD424042 showed good therapeutic indices between the anticonvulsant activity and the motor impairment. On the contrary, no anticonvulsant effects but severe lethality were observed in the primary anticonvulsant testing of the parent DISO. By performing the whole-cell voltage-clamp experiments in dispersed cortical neurons we demonstrated that ADD424042 decreased the maximal amplitude of voltage-gated sodium channels with an IC50 value in nM range. Moreover, the compound enhanced use-dependent block and decreased excitability in pyramidal neurons in the current-clamp experiments in cortical slices. Importantly, we found that ADD424042 possessed either no, or very small cardiotoxic effect. In contrast to DISO, ADD424042 did not produce any apparent changes in electrocardiogram (ECG) and arterial blood pressure recordings. ADD424042 had no effect on QT and corrected QT intervals, at a dose which was 15 times higher than ED50 for the anticonvulsant effect in the MES model. Taken together, these data suggest that ADD424042 has the potential to become a lead structure for novel broadly acting AEDs with wide margin of cardiac safety.

  20. Add neurons, subtract anxiety

    PubMed Central

    Kheirbek, Mazen A.; Hen, René

    2014-01-01

    IN BRIEF To keep memories from becoming jumbled, the brain must encode the distinct features of events and situations in a way that allows them to be distinguished from one another—a process called pattern separation. Pattern separation enables us to distinguish dangerous situations from similar ones that pose no risk. People with defects in this ability may be prone to anxiety disorders. The process occurs in one of the two regions of the brain that generate neurons throughout life. These fledgling cells seem to be critical to pattern separation. Interventions that specifically boost the ranks of rookie neurons could provide new ways to regulate mood and possibly treat conditions such as post-traumatic stress disorder. PMID:24974712