Science.gov

Sample records for add-on control devices

  1. 40 CFR 63.9323 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 14 2010-07-01 2010-07-01 false How do I determine the add-on control... the add-on control device simultaneously, using either Method 25 or 25A of appendix A to 40 CFR part... than 50 parts per million at the control device outlet. (2) Use Method 25A of appendix A to 40 CFR...

  2. 40 CFR 63.3174 - What are the requirements for a capture system or add-on control device which is not taken into...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... system or add-on control device which is not taken into account when demonstrating compliance with the... system or add-on control device which is not taken into account when demonstrating compliance with the applicable emission limitations? You may have capture systems or add-on control devices which you choose...

  3. 40 CFR 63.3174 - What are the requirements for a capture system or add-on control device which is not taken into...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... capture system or add-on control device which is not taken into account when demonstrating compliance with... capture system or add-on control device which is not taken into account when demonstrating compliance with the applicable emission limitations? You may have capture systems or add-on control devices which...

  4. 40 CFR 63.3174 - What are the requirements for a capture system or add-on control device which is not taken into...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... capture system or add-on control device which is not taken into account when demonstrating compliance with... capture system or add-on control device which is not taken into account when demonstrating compliance with the applicable emission limitations? You may have capture systems or add-on control devices which...

  5. 40 CFR 63.4767 - How do I establish the emission capture system and add-on control device operating limits during...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... capture system and add-on control device operating limits during the performance test? 63.4767 Section 63... capture system and add-on control device operating limits during the performance test? During the... efficiency according to § 63.4766. (c) Carbon adsorbers. If your add-on control device is a carbon...

  6. 40 CFR 63.3967 - How do I establish the emission capture system and add-on control device operating limits during...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... capture system and add-on control device operating limits during the performance test? 63.3967 Section 63... establish the emission capture system and add-on control device operating limits during the performance test... catalytic oxidizer. (c) Regenerative carbon adsorbers. If your add-on control device is a...

  7. 40 CFR 63.9323 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... the add-on control device simultaneously, using either Method 25 or 25A of appendix A to 40 CFR part... both the inlet and outlet measurements. (1) Use Method 25 of appendix A to 40 CFR part 60 if the add-on.... (1) Use Method 1 or 1A of appendix A to 40 CFR part 60, as appropriate, to select sampling sites...

  8. 40 CFR 63.9323 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... the add-on control device simultaneously, using either Method 25 or 25A of appendix A to 40 CFR part... both the inlet and outlet measurements. (1) Use Method 25 of appendix A to 40 CFR part 60 if the add-on.... (1) Use Method 1 or 1A of appendix A to 40 CFR part 60, as appropriate, to select sampling sites...

  9. 40 CFR 63.9323 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... the add-on control device simultaneously, using either Method 25 or 25A of appendix A to 40 CFR part... both the inlet and outlet measurements. (1) Use Method 25 of appendix A to 40 CFR part 60 if the add-on.... (1) Use Method 1 or 1A of appendix A to 40 CFR part 60, as appropriate, to select sampling sites...

  10. 40 CFR 63.3546 - How do I establish the emission capture system and add-on control device operating limits during...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... capture system and add-on control device operating limits during the performance test? 63.3546 Section 63... the Emission Rate with Add-on Controls Option § 63.3546 How do I establish the emission capture system... the emission stream for leakage. (d) Carbon adsorbers. If your add-on control device is a...

  11. 40 CFR 63.4567 - How do I establish the emission capture system and add-on control device operating limits during...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... capture system and add-on control device operating limits during the performance test? 63.4567 Section 63... emission capture system and add-on control device operating limits during the performance test? During the... operating limits for that catalytic oxidizer. (c) Regenerative carbon adsorbers. If your add-on...

  12. 40 CFR Table 1 to Subpart IIIi of... - Operating Limits for Capture Systems and Add-On Control Devices

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... of appendix M to 40 CFR part 51 i. Collecting the direction of air flow, and either the facial... 40 Protection of Environment 13 2013-07-01 2012-07-01 true Operating Limits for Capture Systems... Subpart IIII of Part 63—Operating Limits for Capture Systems and Add-On Control Devices If you...

  13. 40 CFR 63.4767 - How do I establish the emission capture system and add-on control device operating limits during...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 12 2011-07-01 2009-07-01 true How do I establish the emission capture... Rate with Add-on Controls Option § 63.4767 How do I establish the emission capture system and add-on...) Carbon adsorbers. If your add-on control device is a carbon adsorber, establish the operating...

  14. 40 CFR 63.4566 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... appendix A to 40 CFR part 60. (1) Use Method 25 if the add-on control device is an oxidizer and you expect... paragraphs (a)(1) through (5) of this section. (1) Use Method 1 or 1A of appendix A to 40 CFR part 60, as... appendix A to 40 CFR part 60, as appropriate, to measure gas volumetric flow rate. (3) Use Method 3, 3A,...

  15. 40 CFR 63.4566 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... appendix A to 40 CFR part 60. (1) Use Method 25 if the add-on control device is an oxidizer and you expect... paragraphs (a)(1) through (5) of this section. (1) Use Method 1 or 1A of appendix A to 40 CFR part 60, as... appendix A to 40 CFR part 60, as appropriate, to measure gas volumetric flow rate. (3) Use Method 3, 3A,...

  16. 40 CFR 63.4566 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... outlet of the add-on control device simultaneously, using either Method 25 or 25A of appendix A to 40 CFR...) through (5) of this section. (1) Use Method 1 or 1A of appendix A to 40 CFR part 60, as appropriate, to... to 40 CFR part 60, as appropriate, to measure gas volumetric flow rate. (3) Use Method 3, 3A, or...

  17. 40 CFR 63.4566 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... appendix A to 40 CFR part 60. (1) Use Method 25 if the add-on control device is an oxidizer and you expect... paragraphs (a)(1) through (5) of this section. (1) Use Method 1 or 1A of appendix A to 40 CFR part 60, as... appendix A to 40 CFR part 60, as appropriate, to measure gas volumetric flow rate. (3) Use Method 3, 3A,...

  18. 40 CFR 63.3556 - How do I establish the emission capture system and add-on control device operating limits during...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... capture system and add-on control device operating limits during the performance test? 63.3556 Section 63... the Control Efficiency/outlet Concentration Option § 63.3556 How do I establish the emission capture... the emission stream for leakage. (d) Carbon adsorbers. If your add-on control device is a...

  19. 40 CFR 63.3967 - How do I establish the emission capture system and add-on control device operating limits during...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 13 2013-07-01 2012-07-01 true How do I establish the emission capture... emission capture system and add-on control device operating limits during the performance test? During the... catalytic oxidizer. (c) Regenerative carbon adsorbers. If your add-on control device is a...

  20. 40 CFR 63.4167 - How do I establish the emission capture system and add-on control device operating limits during...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... capture system and add-on control device operating limits during the performance test? 63.4167 Section 63... capture system and add-on control device operating limits during the performance test? During the... conduct a new performance test to determine destruction efficiency according to § 63.4166. (c)...

  1. 40 CFR 63.3967 - How do I establish the emission capture system and add-on control device operating limits during...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 12 2011-07-01 2009-07-01 true How do I establish the emission capture... capture system and add-on control device operating limits during the performance test? During the... catalytic oxidizer. (c) Regenerative carbon adsorbers. If your add-on control device is a...

  2. 40 CFR 63.3546 - How do I establish the emission capture system and add-on control device operating limits during...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 13 2013-07-01 2012-07-01 true How do I establish the emission capture... Emission Rate with Add-on Controls Option § 63.3546 How do I establish the emission capture system and add... the emission stream for leakage. (d) Carbon adsorbers. If your add-on control device is a...

  3. 40 CFR 63.4767 - How do I establish the emission capture system and add-on control device operating limits during...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 13 2013-07-01 2012-07-01 true How do I establish the emission capture... for the Emission Rate with Add-on Controls Option § 63.4767 How do I establish the emission capture...) Carbon adsorbers. If your add-on control device is a carbon adsorber, establish the operating...

  4. 40 CFR 63.4966 - How do I establish the emission capture system and add-on control device operating limits during...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... provisions for the use of an alternative monitoring method as set forth in 40 CFR 63.8(f). ... capture system and add-on control device operating limits during the performance test? 63.4966 Section 63... for the Emission Rate with Add-on Controls Option § 63.4966 How do I establish the emission...

  5. 40 CFR 63.4567 - How do I establish the emission capture system and add-on control device operating limits during...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 13 2013-07-01 2012-07-01 true How do I establish the emission capture... capture system and add-on control device operating limits during the performance test? During the... operating limits for that catalytic oxidizer. (c) Regenerative carbon adsorbers. If your add-on...

  6. 40 CFR 63.3556 - How do I establish the emission capture system and add-on control device operating limits during...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 13 2013-07-01 2012-07-01 true How do I establish the emission capture... Control Efficiency/outlet Concentration Option § 63.3556 How do I establish the emission capture system... the emission stream for leakage. (d) Carbon adsorbers. If your add-on control device is a...

  7. 40 CFR Table 4 to Subpart Vvvv of... - Operating Limits if Using an Add-on Control Device for Open Molding Operations

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Operating Limits if Using an Add-on Control Device for Open Molding Operations 4 Table 4 to Subpart VVVV of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE...

  8. 40 CFR Table 4 to Subpart Vvvv of... - Operating Limits if Using an Add-on Control Device for Open Molding Operations

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... be at least 0.007 inch H2O, as established in Method 204 of appendix M to 40 CFR part 51 i... Control Device for Open Molding Operations 4 Table 4 to Subpart VVVV of Part 63 Protection of Environment... Limits if Using an Add-on Control Device for Open Molding Operations As specified in §§ 63.5715(a) and...

  9. 40 CFR Table 4 to Subpart Vvvv of... - Operating Limits if Using an Add-on Control Device for Open Molding Operations

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... be at least 0.007 inch H2O, as established in Method 204 of appendix M to 40 CFR part 51 i... Control Device for Open Molding Operations 4 Table 4 to Subpart VVVV of Part 63 Protection of Environment... Limits if Using an Add-on Control Device for Open Molding Operations As specified in §§ 63.5715(a) and...

  10. 40 CFR Table 4 to Subpart Vvvv of... - Operating Limits if Using an Add-on Control Device for Open Molding Operations

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... be at least 0.007 inch H2O, as established in Method 204 of appendix M to 40 CFR part 51 i... Control Device for Open Molding Operations 4 Table 4 to Subpart VVVV of Part 63 Protection of Environment... Limits if Using an Add-on Control Device for Open Molding Operations As specified in §§ 63.5715(a) and...

  11. 40 CFR 63.4167 - How do I establish the emission capture system and add-on control device operating limits during...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 12 2011-07-01 2009-07-01 true How do I establish the emission capture... with Add-on Controls Option § 63.4167 How do I establish the emission capture system and add-on control... test to determine destruction efficiency according to § 63.4166. (c) Carbon adsorbers. If your...

  12. 40 CFR 63.4567 - How do I establish the emission capture system and add-on control device operating limits during...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 12 2011-07-01 2009-07-01 true How do I establish the emission capture... Emission Rate with Add-on Controls Option § 63.4567 How do I establish the emission capture system and add... operating limits for that catalytic oxidizer. (c) Regenerative carbon adsorbers. If your add-on...

  13. 40 CFR 63.4966 - How do I establish the emission capture system and add-on control device operating limits during...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... provisions for the use of an alternative monitoring method as set forth in 40 CFR 63.8(f). ... 40 Protection of Environment 12 2011-07-01 2009-07-01 true How do I establish the emission capture... with Add-on Controls Option § 63.4966 How do I establish the emission capture system and add-on...

  14. ERDA's portfolio: solar add-on device construction manuals

    SciTech Connect

    Barron, J.J.; Cole, W.J.

    1981-01-01

    The New York State Energy Research and Development Authority (ERDA) has developed a portfolio of eight (8) instructional manuals for the construction of the following solar add-on devices: thermosiphoning hot water system; standard domestic hot water system; bread box type hot water system; add-on greenhouse space heating system (with mass); add-on sunspace space heating system (without mass); thermosiphoning air panel space heating system; fan assisted air panel space heating system; Trombe wall space heating system. In addition to step-by-step instructions and illustrations of device construction, each manual contains a list of materials and specifications (including estimated costs in 1980 dollars and sources of supply), guidelines for appropriate siting and installation, and energy performance estimates under optimal and non-optimal conditions. This portfolio of solar add-on devices is directed toward the do-it-yourself homeowner, builders and home improvement contractors, and weatherization organizations. Each instruction manual is a complete, self-contained module suitable for distribution separately or as part of the portfolio. Each manual also has an educational module associated with it including color slides, which is designed for use by community colleges, industrial high schools and adult educational programs. An outline is presented of the content of the design packages,as well as a description of ERDA's plans for distribution of the designs and educating the public on their use, and information on how to obtain individual construction manuals or the entire portfolio.

  15. 40 CFR 63.4966 - How do I establish the emission capture system and add-on control device operating limits during...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... provisions for the use of an alternative monitoring method as set forth in 40 CFR 63.8(f). ... 40 Protection of Environment 13 2013-07-01 2012-07-01 true How do I establish the emission capture... Emission Rate with Add-on Controls Option § 63.4966 How do I establish the emission capture system and...

  16. 40 CFR 63.4167 - How do I establish the emission capture system and add-on control device operating limits during...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 13 2013-07-01 2012-07-01 true How do I establish the emission capture... Emission Rate with Add-on Controls Option § 63.4167 How do I establish the emission capture system and add... test to determine destruction efficiency according to § 63.4166. (c) Carbon adsorbers. If your...

  17. 40 CFR Table 4 to Subpart Vvvv of... - Operating Limits if Using an Add-on Control Device for Open Molding Operations

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ....007 inch H2O, as established in Method 204 of appendix M to 40 CFR part 51 i. Collecting the direction... Control Device for Open Molding Operations 4 Table 4 to Subpart VVVV of Part 63 Protection of Environment...-on Control Device for Open Molding Operations As specified in §§ 63.5715(a) and 63.5725(f)(5),...

  18. ENVIRONMENTAL TECHNOLOGY VERIFICATION: ADD-ON NOX CONTROLS

    EPA Science Inventory

    The paper discusses the environmental technology verification (ETV) of add-on nitrogen oxide (NOx) controls. Research Triangle Institute (RTI) is EPA's cooperating partner for the Air Pollution Control Technology (APCT) Program, one of a dozen ETV pilot programs. Verification of ...

  19. Randomized Controlled Trials of Add-On Antidepressants in Schizophrenia

    PubMed Central

    Joffe, Grigori; Stenberg, Jan-Henry

    2015-01-01

    Background: Despite adequate treatment with antipsychotics, a substantial number of patients with schizophrenia demonstrate only suboptimal clinical outcome. To overcome this challenge, various psychopharmacological combination strategies have been used, including antidepressants added to antipsychotics. Methods: To analyze the efficacy of add-on antidepressants for the treatment of negative, positive, cognitive, depressive, and antipsychotic-induced extrapyramidal symptoms in schizophrenia, published randomized controlled trials assessing the efficacy of adjunctive antidepressants in schizophrenia were reviewed using the following parameters: baseline clinical characteristics and number of patients, their on-going antipsychotic treatment, dosage of the add-on antidepressants, duration of the trial, efficacy measures, and outcomes. Results: There were 36 randomized controlled trials reported in 41 journal publications (n=1582). The antidepressants used were the selective serotonin reuptake inhibitors, duloxetine, imipramine, mianserin, mirtazapine, nefazodone, reboxetin, trazodone, and bupropion. Mirtazapine and mianserin showed somewhat consistent efficacy for negative symptoms and both seemed to enhance neurocognition. Trazodone and nefazodone appeared to improve the antipsychotics-induced extrapyramidal symptoms. Imipramine and duloxetine tended to improve depressive symptoms. No clear evidence supporting selective serotonin reuptake inhibitors’ efficacy on any clinical domain of schizophrenia was found. Add-on antidepressants did not worsen psychosis. Conclusions: Despite a substantial number of randomized controlled trials, the overall efficacy of add-on antidepressants in schizophrenia remains uncertain mainly due to methodological issues. Some differences in efficacy on several schizophrenia domains seem, however, to exist and to vary by the antidepressant subgroups—plausibly due to differences in the mechanisms of action. Antidepressants may not worsen

  20. 40 CFR Table 1b to Subpart Dddd of... - Add-on Control Systems Compliance Options

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 13 2013-07-01 2012-07-01 true Add-on Control Systems Compliance Options 1B Table 1B to Subpart DDDD of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Products Pt. 63, Subpt. DDDD, Table 1B Table 1B to Subpart DDDD of Part 63—Add-on Control...

  1. 40 CFR Table 1b to Subpart Dddd of... - Add-on Control Systems Compliance Options

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 13 2014-07-01 2014-07-01 false Add-on Control Systems Compliance Options 1B Table 1B to Subpart DDDD of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Products Pt. 63, Subpt. DDDD, Table 1B Table 1B to Subpart DDDD of Part 63—Add-on Control...

  2. 40 CFR Table 1b to Subpart Dddd of... - Add-on Control Systems Compliance Options

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 13 2012-07-01 2012-07-01 false Add-on Control Systems Compliance Options 1B Table 1B to Subpart DDDD of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Products Pt. 63, Subpt. DDDD, Table 1B Table 1B to Subpart DDDD of Part 63—Add-on Control...

  3. 40 CFR 75.34 - Units with add-on emission controls.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... assurance/quality control program for the unit, required by section 1 in appendix B of this part. To provide... parametric data to verify the proper operation of the SO2 or NOX add-on emission controls during each hour, as described in paragraph (d) of this section. For any missing data hour(s) in which such...

  4. 40 CFR 75.34 - Units with add-on emission controls.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... assurance/quality control program for the unit, required by section 1 in appendix B of this part. To provide... parametric data to verify the proper operation of the SO2 or NOX add-on emission controls during each hour, as described in paragraph (d) of this section. For any missing data hour(s) in which such...

  5. 40 CFR 75.34 - Units with add-on emission controls.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... assurance/quality control program for the unit, required by section 1 in appendix B of this part. To provide... parametric data to verify the proper operation of the SO2 or NOX add-on emission controls during each hour, as described in paragraph (d) of this section. For any missing data hour(s) in which such...

  6. 40 CFR 75.34 - Units with add-on emission controls.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... assurance/quality control program for the unit, required by section 1 in appendix B of this part. To provide... parametric data to verify the proper operation of the SO2 or NOX add-on emission controls during each hour, as described in paragraph (d) of this section. For any missing data hour(s) in which such...

  7. Aerodynamic drag reduction tests on a full-scale tractor-trailer combination with several add-on devices

    NASA Technical Reports Server (NTRS)

    Montoya, L. C.; Steers, L. L.

    1974-01-01

    Aerodynamic drag tests were performed on a conventional cab-over-engine tractor with a 45-foot trailer and five commercially available or potentially available add-on devices using the coast-down method. The tests ranged in velocity from approximately 30 miles per hour to 65 miles per hour and included some flow visualization. A smooth, level runway at Edwards Air Force Base was used for the tests, and deceleration measurements were taken with both accelerometers and stopwatches. An evaluation of the drag reduction results obtained with each of the five add-on devices is presented.

  8. Add-on fluvoxamine treatment for schizophrenia: an updated meta-analysis of randomized controlled trials.

    PubMed

    Kishi, Taro; Hirota, Tomoya; Iwata, Nakao

    2013-12-01

    We performed an updated meta-analysis of fluvoxamine add-on therapy in patients with schizophrenia treated with antipsychotics based on two previous meta-analyses (Sepehry et al., in J Clin Psychiatry 68:604-610, 2007 and Singh et al., in Br J Psychiatry J Mental Sci 197:174-179, 2010). We searched PubMed, the Cochrane Library database, and PsycINFO up to January 2013. We conducted a systematic review and meta-analysis of individual patient data from randomized controlled trials comparing fluvoxamine add-on therapy with placebo. The risk ratio (RR), 95 % confidence intervals (CI), and standardized mean difference (SMD) were calculated. Seven studies (total n = 272) were identified. These included two clozapine studies, one olanzapine study, one second-generation antipsychotic (SGA) monotherapy study, and three first-generation antipsychotics (FGAs) monotherapy studies. There were significant effect of fluvoxamine add-on therapy on overall (SMD = -0.46, CI = -0.75 to -0.16, p = 0.003, I (2) = 0 %, 5 studies, n = 180) and negative symptoms (SMD = -0.44, CI = -0.74 to -0.14, p = 0.004, I (2) = 0 %, 5 studies, n = 180). However, fluvoxamine add-on therapy showed no significant effects on positive symptoms, depressive symptoms, and discontinuations from any cause or adverse events. Fluvoxamine add-on therapy in patients primarily treated with SGAs improved overall (p = 0.02) but not negative symptoms (p = 0.31). On the other hand, fluvoxamine add-on therapy in patients primarily treated with FGAs improved both overall (p = 0.04) and negative symptoms (p = 0.004) compared with control groups. Our results suggest that fluvoxamine add-on therapy is more beneficial on the psychopathology (especially negative symptoms) than controls in patients with schizophrenia who are primarily treated with FGAs. Given that a small number of studies were included in this meta-analysis, the results should be treated with caution. PMID:23605347

  9. The importance of postprandial glycemic control: optimizing add-on therapy to basal insulin.

    PubMed

    Shaefer, Charles F; Anderson, John

    2016-01-01

    Diabetes, mainly type 2 diabetes mellitus (T2DM), is associated with a growing clinical and economic burden in the United States, which is expected to increase in association with an aging population. Sufficient glycemic control in patients with T2DM, in order to reduce the risk of micro- and macrovascular complications associated with diabetes, is mediated by lifestyle modifications and a regimen of increasingly intensive antidiabetes drugs. Several treatments and strategies are available for primary care physicians to select from when choosing the most appropriate therapy for their individual patients with T2DM, but, ultimately, due to the progressive nature of the disease, most of these patients will require insulin therapy to maintain glycemic control. Regimens containing basal and postprandial insulins are widely used, but there is still widespread reluctance to initiate insulin treatment due to fear of weight gain and hypoglycemia. Furthermore, as patients approach recommended glycated hemoglobin targets, postprandial hyperglycemia becomes the main contributor to hyperglycemic exposure, necessitating the timely initiation of prandial treatment. Finally, insulin treatment can be limited by factors like the number of injections, mealtime restrictions, complex titration algorithms and patient adherence. Recent developments in antidiabetes drug research have brought more convenient basal and postprandial regimens closer. Clinical evaluation of the efficacy and safety of basal insulins plus add-on glucagon-like peptide-1 receptor agonists (GLP-1 RAs) has yielded promising results. Primary care physicians are continually challenged to optimize insulin treatment strategies to maximize patient outcomes. Emerging strategies such as long-acting basal insulin analogs and short-acting GLP-1 RAs are particularly appealing to address this challenge. PMID:26548422

  10. 40 CFR 75.34 - Units with add-on emission controls.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... the necessary documentation, the owner or operator shall, for each missing data period, record... ozone season, the procedures of § 75.33 may be applied unconditionally, i.e., documentation of the operational status of the emission controls is not required in order to apply the standard missing...

  11. TEST DESIGN FOR ENVIRONMENTAL TECHNOLOGY VERIFICATION (ETV) OF ADD-ON NOX CONTROL UTILIZING OZONE INJECTION

    EPA Science Inventory

    The paper discusses the test design for environmental technology verification (ETV) of add-0n nitrogen oxides (NOx) control utilizing ozone injection. (NOTE: ETV is an EPA-established program to enhance domestic and international market acceptance of new or improved commercially...

  12. Effects of add-on montelukast on airway hyperresponsiveness in patients with well-controlled asthma – a pilot study

    PubMed Central

    Kononowa, Nina; Michel, Sandra; Miedinger, David; Pichler, Christiane E.; Chhajed, Prashant N.; Helbling, Arthur; Leuppi, Jörg D.

    2013-01-01

    Objective Control of airway inflammation is the cornerstone of asthma management. The aim of the present pilot study was to assess the effects of a leukotriene receptor antagonist (LTRA) added to a basic treatment of inhaled corticosteroids (ICS) and long-acting beta-agonist (LABA) on airway hyperresponsiveness, inflammation, and quality of life in well-controlled patients with asthma. Research design and methods Seventeen patients (age 18–65, 11 women) with well-controlled asthma presenting airway hyperresponsiveness to mannitol and methacholine challenge were given add-on montelukast on a stable ICS + LABA for 4 weeks. Quality of life and selected parameters of airway inflammation were measured at baseline and at study end. (ClinicalTrials.gov (NCT01725360)). Results Adding montelukast to ICS + LABA resulted in an increase in mean FEV1 (+4.5%, p = 0.057), cumulated higher dose of mannitol (+32.5%, p = 0.023) and methacholine (+17.2%, 0.237) in the provocation test, lower airway reactivity with mannitol and methacholine (response dose ratio (RDR) –50.0%, p = 0.024 and –44.3%, p = 0.006, respectively), and improved airway sensitivity to mannitol and methacholine (+12.1%, p = 0.590 and +48.0%, p = 0.129 for PD15 and PD20 FEV1, respectively). Changes in inflammation parameters (blood eosinophil count, serum eosinophil cationic protein, and exhaled nitric oxide) were consistent with these findings. Asthma-related quality of life improved significantly in all domains and overall (from 5.3 at baseline to 6.1 at the final visit, p < 0.001). The main limitation was the absence of a control group. Conclusion The consistency of the changes in airway hyperresponsiveness and inflammation as well as in quality of life observed with an add-on therapy with montelukast in well-controlled asthma patients during 4 weeks suggests that residual inflammation may represent an area for further improvement of asthma control to be explored in

  13. Metered dose inhaler add-on devices: is the inhaled mass of drug dependent on the size of the infant?

    PubMed

    Turpeinen, M; Nikander, K; Malmberg, L P; Pelkonen, A

    1999-01-01

    Limited cooperation and low tidal volumes in infants make aerosol therapy difficult. We measured the amount of drug delivered from two baby spacer devices especially developed for use in infants. Designed as a randomized crossover study, aerolized budesonide from a pressurized metered dose inhaler (pMDI) was collected in the inspiratory filter interposed between the face mask and the spacer in 13 infants aged from 2 to 19 months old. The study was performed in connection with pulmonary function testing with a plethysmograph, and the children were sedated with cloral hydrate. Two small-volume baby spacer devices were used: a Babyhaler spacer (GlaxoWellcome, Hertfordshire, UK) made of polycarbonate with a volume of 350 mL and a built-in dead space of 40 mL and a NebuChamber spacer (AstraZeneca, Lund, Sweden) made of stainless steel with a volume of 250 mL and no dead space. Budesonide delivery from the NebuChamber was significantly higher than from the Babyhaler: 38.2% (range, 28.3%-47.5%) of the nominal dose versus 12% (range, 3.3%-21.25%) of the nominal dose of 400 micrograms of budesonide (P = 0.002). The inhaled mass of budesonide from the Babyhaler correlated significantly with skin surface area (r = 0.68, P = 0.018), weight (r = 0.66, P = 0.019), height (r = 0.69; P = 0.017), tidal volume (r = 0.82; P = 0.004), and minute volume (r = 0.67; P = 0.019). No correlations were found between these variables and the inhaled mass of budesonide from the NebuChamber. The results indicate that the design of the NebuChamber spacer affords stable drug delivery in infants and that a large variability in the inhaled mass of drug may be found when infants are inhaling from different baby spacers. PMID:10623333

  14. N-Acetylcysteine in the Treatment of Pediatric Trichotillomania: A Randomized, Double-Blind, Placebo-Controlled Add-On Trial

    ERIC Educational Resources Information Center

    Bloch, Michael H.; Panza, Kaitlyn E.; Grant, Jon E.; Pittenger, Christopher; Leckman, James F.

    2013-01-01

    Objective: To examine the efficacy of N-acetylcysteine (NAC) for the treatment of pediatric trichotillomania (TTM) in a double-blind, placebo-controlled, add-on study. Method: A total of 39 children and adolescents aged 8 to 17 years with pediatric trichotillomania were randomly assigned to receive NAC or matching placebo for 12 weeks. Our primary…

  15. Add-on mirtazapine improves depressive symptoms in schizophrenia: a double-blind randomized placebo-controlled study with an open-label extension phase.

    PubMed

    Terevnikov, Viacheslav; Stenberg, Jan-Henry; Tiihonen, Jari; Joffe, Marina; Burkin, Mark; Tchoukhine, Evgueni; Joffe, Grigori

    2011-04-01

    Depression is common in schizophrenia and worsens its course. The role of antidepressants for schizophrenic depression remains unclear. In this study, the efficacy of add-on mirtazapine on depression in schizophrenia was explored in a subsidiary arm of a recent randomized controlled trial. Patients (n = 41) with chronic but stable schizophrenia and inadequate response to stable doses of different first-generation antipsychotics were treated with add-on mirtazapine 30 mg or placebo during a 6-week double-blind phase and with open-label add-on mirtazapine during a 6-week extension phase. Efficacy measures were the Calgary Depression Scale for Schizophrenia (CDSS) and the Positive and Negative Syndrome Scale depression item. During the double-blind phase, both measures' scores decreased significantly in the mirtazapine group but not in the placebo group (for the CDSS, 52.0% vs 19.6%, respectively). During the open‐label phase, both groups demonstrated significant improvements. In between‐group comparison, a trend favoring mirtazapine did not reach statistical significance. The changes in the CDSS correlated positively with those in the Positive and Negative Syndrome Scale negative, positive and total (sub)scales for mirtazapine‐treated patients during the double‐blind phase. Depressed patients with schizophrenia may benefit from mirtazapine–first‐generation antipsychotics combination, with no increased risk for psychosis. However, more studies are needed. PMID:21469215

  16. Exhaled Nitric Oxide Fraction as an Add-On to ACQ-7 for Not Well Controlled Asthma Detection

    PubMed Central

    Plaza, Vicente; Ramos-Barbón, David; Muñoz, Ana María; Fortuna, Ana María; Crespo, Astrid; Murio, Cristina; Palomino, Rosa

    2013-01-01

    Background The measurement of fractional nitric oxide concentration in exhaled breath (FeNO), a noninvasive indicator of airway inflammation, remains controversial as a tool to assess asthma control. Guidelines currently limit asthma control assessment to symptom and spirometry based appraisals such as the Asthma Control Questionnaire-7 (ACQ-7). We aimed at determining whether adding FeNO to ACQ-7 improves current asthma clinical control assessment, through enhanced detection of not well controlled asthma. Methods Asthmatic subjects, classified as not well controlled as per ACQ-7 on regular clinical practice, were included in a prospective, multicenter fashion, and had their maintenance treatment adjusted on visit 1. On follow-up (visit 2) four weeks later, the subjects were reevaluated as controlled or not well controlled using ACQ-7 versus a combination of FeNO and ACQ-7. Results Out of 381 subjects enrolled, 225 (59.1%) had not well controlled asthma on visit 2 as determined by ACQ-7, and 264 (69.3%) as per combined FeNO and ACQ-7. The combination of FeNO to ACQ-7 increased by 14.8% the detection of not well controlled asthma following maintenance therapy adjustment. Conclusions The addition of FeNO to ACQ-7 increased the detectability of not well controlled asthma upon adjustment of maintenance therapy. Adding a measure of airway inflammation to usual symptom and spirometry based scores increases the efficacy of current asthma clinical control assessment. PMID:24204742

  17. DEVICE CONTROLLER, CAMERA CONTROL

    1998-07-20

    This is a C++ application that is the server for the cameral control system. Devserv drives serial devices, such as cameras and videoswitchers used in a videoconference, upon request from a client such as the camxfgbfbx ccint program. cc Deverv listens on UPD ports for clients to make network contractions. After a client connects and sends a request to control a device (such as to pan,tilt, or zooma camera or do picture-in-picture with a videoswitcher),more » devserv formats the request into an RS232 message appropriate for the device and sends this message over the serial port to which the device is connected. Devserv then reads the reply from the device from the serial port to which the device is connected. Devserv then reads the reply from the device from the serial port and then formats and sends via multicast a status message. In addition, devserv periodically multicasts status or description messages so that all clients connected to the multicast channel know what devices are supported and their ranges of motion and the current position. The software design employs a class hierarchy such that an abstract base class for devices can be subclassed into classes for various device categories(e.g. sonyevid30, cononvco4, panasonicwjmx50, etc.). which are further subclassed into classes for various device categories. The devices currently supported are the Sony evi-D30, Canon, VCC1, Canon VCC3, and Canon VCC4 cameras and the Panasonic WJ-MX50 videoswitcher. However, developers can extend the class hierarchy to support other devices.« less

  18. DEVICE CONTROLLER, CAMERA CONTROL

    SciTech Connect

    Perry, Marcia

    1998-07-20

    This is a C++ application that is the server for the cameral control system. Devserv drives serial devices, such as cameras and videoswitchers used in a videoconference, upon request from a client such as the camxfgbfbx ccint program. cc Deverv listens on UPD ports for clients to make network contractions. After a client connects and sends a request to control a device (such as to pan,tilt, or zooma camera or do picture-in-picture with a videoswitcher), devserv formats the request into an RS232 message appropriate for the device and sends this message over the serial port to which the device is connected. Devserv then reads the reply from the device from the serial port to which the device is connected. Devserv then reads the reply from the device from the serial port and then formats and sends via multicast a status message. In addition, devserv periodically multicasts status or description messages so that all clients connected to the multicast channel know what devices are supported and their ranges of motion and the current position. The software design employs a class hierarchy such that an abstract base class for devices can be subclassed into classes for various device categories(e.g. sonyevid30, cononvco4, panasonicwjmx50, etc.). which are further subclassed into classes for various device categories. The devices currently supported are the Sony evi-D30, Canon, VCC1, Canon VCC3, and Canon VCC4 cameras and the Panasonic WJ-MX50 videoswitcher. However, developers can extend the class hierarchy to support other devices.

  19. CONTROL LIMITER DEVICE

    DOEpatents

    DeShong, J.A.

    1960-03-01

    A control-limiting device for monltoring a control system is described. The system comprises a conditionsensing device, a condition-varying device exerting a control over the condition, and a control means to actuate the condition-varying device. A control-limiting device integrates the total movement or other change of the condition-varying device over any interval of time during a continuum of overlapping periods of time, and if the tothl movement or change of the condition-varying device exceeds a preset value, the control- limiting device will switch the control of the operated apparatus from automatic to manual control.

  20. Add-on montelukast in inadequately controlled asthma patients in a 6-month open-label study: the MONtelukast In Chronic Asthma (MONICA) study.

    PubMed

    Virchow, J Christian; Mehta, Anish; Ljungblad, Li; Mitfessel, Harald

    2010-05-01

    Bronchial asthma often remains uncontrolled despite treatment with inhaled corticosteroids (ICS), long-acting beta(2)-agonists (LABA) or both, necessitating additional treatment. Patients >or=18 years (n=1681) with mild-to-moderate asthma received oral montelukast 10mg added to ICS or ICS+LABAs, and were followed for 6 months in a prospective, open-label observational study. The primary endpoint was change in Asthma Control Test (ACT) score. Secondary endpoints included mini-Asthma Quality-of-Life Questionnaire (mini-AQLQ) and FEV(1)/PEF. Mean ACT scores improved from 14.6+/-4.6 (baseline) to 19.4+/-4.4 (month 6; p<0.0001). Using ACT score categories, the percentage of patients with uncontrolled (57.5%) or poorly controlled (25.0%) asthma at baseline decreased at month 6 (17.6 and 21.7%, respectively); the percentage of patients with well controlled (13.9%) or completely controlled (1.2%) asthma at baseline increased at month 6 (47.5 and 11.4%, respectively). The mini-AQLQ score (mean+/-SD) improved from 4.0+/-1.1 to 5.3+/-1.1 (p<0.0001); FEV(1) increased from 2.46+/-0.89 to 2.60+/-0.92L (p<0.0001). Treatment with montelukast was generally well tolerated. In patients insufficiently controlled with ICS or ICS+LABAs, daily add-on montelukast improved both asthma control and asthma-related quality of life. Clinicaltrials.gov registry number NCT00802789. PMID:20031382

  1. Lithium as add-on to quetiapine XR in adult patients with acute mania: a 6-week, multicenter, double-blind, randomized, placebo-controlled study.

    PubMed

    Bourin, Michel S; Severus, Emanuel; Schronen, Juan P; Gass, Peter; Szamosi, Johan; Eriksson, Hans; Chandrashekar, Hongally

    2014-01-01

    Quetiapine extended release (XR) and lithium are treatments with proven efficacy in acute mania. This randomized study evaluated the efficacy and safety of lithium or placebo as add-on to quetiapine XR in adult patients with manic or mixed symptoms of bipolar I disorder. In this 6-week, double-blind study (Trial D144AC00003), adult patients with DSM-IV-TR-diagnosed bipolar I disorder (current episode manic or mixed), a Young Mania Rating Scale (YMRS) total score ≥20, and score ≥4 on two of four core YMRS items were administered quetiapine XR (400 to 800 mg/day) and randomly assigned to receive add-on lithium (600 to 1,800 mg/day) or placebo. The primary efficacy end point was change in the YMRS total score from baseline to day 43, analyzed using a mixed-model for repeated measures (MMRM) approach. Secondary efficacy and safety end points were also measured. Rating scales were administered by trained staff. Three hundred fifty-six patients treated with quetiapine XR were randomized to add-on lithium (n = 173) or placebo (n = 183). Two hundred ninety-one patients (81.7%) completed the study. At day 43, least squares mean change in YMRS total score was -22.8 for add-on lithium and -20.1 for add-on placebo, a statistically significant treatment group difference of -2.69 (p < 0.001). On secondary measures, add-on lithium was associated with significant improvements in response, remission, illness severity, and overall illness versus add-on placebo (p < 0.05). The number needed to treat was 9.1 for response and 7.9 for remission for add-on lithium compared with add-on placebo. Lithium in combination with quetiapine XR was generally well tolerated, with a similar profile to quetiapine XR in combination with placebo. The addition of lithium to quetiapine XR therapy was associated with significantly greater efficacy than placebo as add-on and was generally well tolerated in patients with acute bipolar I mania. This study was registered under Clinicaltrials

  2. Comparative effects of telmisartan and valsartan as add-on agents for hypertensive patients with morning blood pressure insufficiently controlled by amlodipine monotherapy.

    PubMed

    Yoshida, Hideaki; Akasaka, Hiroshi; Saitoh, Shigeyuki; Shimamoto, Kazuaki; Miura, Tetsuji

    2014-03-01

    The aim of this study was to determine the efficacies of valsartan and telmisartan as add-on agents for the control of morning blood pressure (BP) in patients already on amlodipine monotherapy. A total of 414 hypertensive patients were prospectively enrolled in a 4-week run-in period when they were treated with amlodipine (5 mg/day), and home BP was measured in the morning and evening. Patients with home systolic BP (SBP) being 135-159 mm Hg in the morning at the end of the run-in period were randomized to additional treatment with valsartan (80 mg/day) or with telmisartan (40 mg/day) for 8 weeks. The primary endpoint was the change in morning home BP, and secondary endpoints included variability of morning home BP. Of the 282 patients randomized, 262 patients (n=131, in each treatment) completed the protocols. Demographic parameters and baseline morning SBP/diastolic BP (DBP) (146.3±7.1/84.8±9.3 vs. 146.0±7.1/84.2±9.1 mm Hg) were comparable in the valsartan group and telmisartan group, and changes in SBP/DBP after 8-week treatment were not significantly different between the two groups (-7.4±10.6/-3.9±6.1 vs. -8.3±9.9/-5.0±5.9 mm Hg). Valsartan significantly increased individual standard deviation and variation coefficient of morning SBP, but telmisartan did not change either of these indices of SBP variation. In subgroups with baseline SBP being above the median (145.2 mm Hg), change in DBP was significantly larger by telmisartan than by valsartan (-6.3±5.6 vs. -3.9±6.7 mm Hg, P<0.05). These results suggest that telmisartan is more useful than valsartan as an add-on agent for reducing the level and variability of morning BP in patients on amlodipine monotherapy. PMID:24108237

  3. Efficacy of Zinc Sulfate as an Add-on Therapy to Risperidone Versus Risperidone Alone in Patients With Schizophrenia: A Double-Blind Randomized Placebo-Controlled Trial

    PubMed Central

    Mortazavi, Mehran; Farzin, Davood; Zarhghami, Mehran; Hosseini, Seyed Hamzeh; Mansoori, Parisa; Nateghi, Gholamreza

    2015-01-01

    Background: Zinc can modulate fast-excitatory transmission, facilitate the release of amino butyric acid and potentiate nicotinic acetylcholine receptors. There are also emerging evidences discussing the implication of these neurotransmitters in pathophysiology of schizophrenia. Objectives: The purpose of this study was to evaluate the efficacy of Zn sulfate as an add-on therapy in the treatment of schizophrenia in a 6-week, double-blind and placebo-controlled trial. Patients and Methods: Eligible participants were 30 inpatients with schizophrenia according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision criteria. Patients were randomly allocated into two equal groups; one group of patients received risperidone 6 mg/day plus capsules of Zn sulfate (each containing 50 mg elemental Zn) three times a day and another group received risperidone 6 mg/day plus placebo. The Positive and Negative Syndrome Scale (PANSS) was applied to assess the psychotic symptoms and aggression risk at baseline, week 2, 4, and 6 of the study. Results: The results of this study showed that both protocols significantly decreased the scores on all subscales of the PANSS and supplemental aggression risk subscale as well as PANSS total score over the study. However, this improvement was significantly higher in Zn sulfate receiving group compared to the placebo group. No major clinical side-effects were detected. Conclusions: It may be concluded that Zn is an effective adjuvant agent in the management of patients with schizophrenia. PMID:26576178

  4. Semi-individualised Chinese medicine treatment as an adjuvant management for diabetic nephropathy: a pilot add-on, randomised, controlled, multicentre, open-label pragmatic clinical trial

    PubMed Central

    Chan, Kam Wa; Ip, Tai Pang; Kwong, Alfred Siu Kei; Lui, Sing Leung; Chan, Gary Chi Wang; Cowling, Benjamin John; Yiu, Wai Han; Wong, Dickson Wai Leong; Liu, Yang; Feng, Yibin; Tan, Kathryn Choon Beng; Chan, Loretta Yuk Yee; Leung, Joseph Chi Kam; Lai, Kar Neng; Tang, Sydney Chi Wai

    2016-01-01

    Introduction Diabetes mellitus and diabetic nephropathy (DN) are prevalent and costly to manage. DN is the leading cause of end-stage kidney disease. Conventional therapy blocking the renin–angiotensin system has only achieved limited effect in preserving renal function. Recent observational data show that the use of Chinese medicine (CM), a major form of traditional medicine used extensively in Asia, could reduce the risk of end-stage kidney disease. However, existing clinical practice guidelines are weakly evidence-based and the effect of CM remains unclear. This trial explores the effect of an existing integrative Chinese–Western medicine protocol for the management of DN. Objective To optimise parameters and assess the feasibility for a subsequent phase III randomised controlled trial through preliminary evaluation on the effect of an adjuvant semi-individualised CM treatment protocol on patients with type 2 diabetes with stages 2–3 chronic kidney disease and macroalbuminuria. Methods and analysis This is an assessor-blind, add-on, randomised, controlled, parallel, multicentre, open-label pilot pragmatic clinical trial. 148 patients diagnosed with DN will be recruited and randomised 1:1 to a 48-week additional semi-individualised CM treatment programme or standard medical care. Primary end points are the changes in estimated glomerular filtration rate and spot urine albumin-to-creatinine ratio between baseline and treatment end point. Secondary end points include fasting blood glucose, glycated haemoglobin, brain natriuretic peptide, fasting insulin, C peptide, fibroblast growth factor 23, urinary monocyte chemotactic protein-1, cystatin C, nephrin, transforming growth factor-β1 and vascular endothelial growth factor. Adverse events are monitored through self-completed questionnaire and clinical visits. Outcomes will be analysed by regression models. Enrolment started in July 2015. Ethics and registration This protocol is approved by the Institutional

  5. The effect of add-on memantine on global function and quality of life in schizophrenia: A randomized, double-blind, controlled, clinical trial

    PubMed Central

    Omranifard, Victoria; Rajabi, Fatemeh; Mohammadian-Sichani, Maryam; Maracy, Mohammad

    2015-01-01

    Background: Schizophrenia severely influences function and quality of life. The benefit of newer antipsychotics in improving the quality of life in schizophrenia still remains controversial. The aim of the present study is to evaluate the effect of memantine on global function and quality of life in patients with schizophrenia. Materials and Methods: This was a randomized controlled trial on inpatient cases of schizophrenia in Noor University Hospital, Isfahan, Iran. A number of 64 patients were selected through sequential sampling; patients were randomly allocated in intervention and placebo groups. The intervention group was treated with memantine plus previously administered, stabled-dose, atypical antipsychotic, while the control group received placebo plus previously administered, stabled-dose, atypical antipsychotic. Memantine administration was initiated at 5 mg daily; the dosage was increased at weekly intervals by 5 mg and finally up-titrated to 20 mg daily within 4 weeks. All patients were assessed by means of Global Assessment of Functioning (GAF) and quality of life scale (QLS) initially and every four weeks to the end of the 12th week. Results: Analysis of baseline GAF and QLS scores showed no significant differences between the two groups (P = 0.081 and P = 0.225, respectively). GAF and QLS scores increased in both groups; but it was higher in the intervention group. The difference between the two groups was statistically significant. (P < 0.001 and P < 0.001, respectively) memantine was well tolerated, with no significant side effects. Conclusion: Add-on memantine was significantly effective in improving the global function of patients as well as their quality of life. PMID:26605240

  6. N-Acetylcysteine in the Treatment of Pediatric Trichotillomania: A Randomized, Double-Blind, Placebo-Controlled Add-On Trial

    PubMed Central

    Bloch, Michael H.; Panza, Kaitlyn E.; Grant, Jon E.; Pittenger, Christopher; Leckman, James F.

    2013-01-01

    Objective To examine the efficacy of N-acetylcysteine (NAC) for the treatment of pediatric trichotillomania (TTM) in a double-blind, placebo-controlled, add-on study. Method A total of 39 children and adolescents aged 8 to 17 years with pediatric trichotillomania were randomly assigned to receive NAC or matching placebo for 12 weeks. Our primary outcome was change in severity of hairpulling as measured by the Massachusetts General Hospital–Hairpulling Scale (MGH-HPS). Secondary measures assessed hairpulling severity, automatic versus focused pulling, clinician-rated improvement, and comorbid anxiety and depression. Outcomes were examined using linear mixed models to test the treatment × time interaction in an intention-to-treat population. Results No significant difference between N-acetylcysteine and placebo was found on any of the primary or secondary outcome measures. On several measures of hairpulling, subjects significantly improved with time regardless of treatment assignment. In the NAC group, 25% of subjects were judged as treatment responders, compared to 21% in the placebo group. Conclusions We observed no benefit of NAC for the treatment of children with trichotillomania. Our findings stand in contrast to a previous, similarly designed trial in adults with TTM, which demonstrated a very large, statistically significant benefit of NAC. Based on the differing results of NAC in pediatric and adult TTM populations, the assumption that pharmacological interventions demonstrated to be effective in adults with TTM will be as effective in children, may be inaccurate. This trial highlights the importance of referring children with TTM to appropriate behavioral therapy before initiating pharmacological interventions, as behavioral therapy has demonstrated efficacy in both children and adults with trichotillomania. PMID:23452680

  7. Comparison of vildagliptin as an add-on therapy and sulfonylurea dose-increasing therapy in patients with inadequately controlled type 2 diabetes using metformin and sulfonylurea (VISUAL study): A randomized trial.

    PubMed

    Hong, A Ram; Lee, Jeun; Ku, Eu Jeong; Hwangbo, Yul; Kim, Kyoung Min; Moon, Jae Hoon; Choi, Sung Hee; Jang, Hak Chul; Lim, Soo

    2015-07-01

    The aim of present study is to compare the efficacy and safety of adding vildagliptin with sulfonylurea dose-increasing as an active comparator in patients who had inadequately controlled type 2 diabetes mellitus (T2DM) using metformin plus sulfonylurea in real clinical practice. Patients using metformin plus sulfonylurea were assigned to either vildagliptin add-on (50 mg twice a day, n=172) or sulfonylurea dose-increasing by 50% (n=172) treatment groups. The primary endpoint was a change in HbA(1c) after 24 weeks. The secondary endpoints were patients achieving HbA(1c)≤7.0% (53 mmol/mol) and changes in the fasting plasma glucose (FPG), 2-h postprandial glucose (2pp), lipid profiles, and urine albumin-to-creatinine ratio. Body weight and hypoglycemia were also investigated. The mean HbA(1c) at baseline was 8.6% (70 mmol/mol) in both groups. At week 24, the adjusted mean HbA(1c) levels decreased by -1.19% (-13.09 mmol/mol) with vildagliptin add-on and -0.46% (-5.06 mmol/mol) with sulfonylurea (P<0.001). Significantly more vildagliptin add-on patients achieved HbA(1c)≤7.0% (53 mmol/mol) than did sulfonylurea patients (40.1% vs. 7.9%; P<0.001). Greater reductions in FPG and 2pp were observed with vildagliptin add-on than with sulfonylurea (P<0.001). The vildagliptin add-on group exhibited no clinically relevant weight gain and had a lower incidence of hypoglycemia compared with the sulfonylurea group. Vildagliptin add-on therapy might be a suitable option for patients with T2DM that is controlled inadequately by metformin and sulfonylurea, based on its greater glucose control and better safety profile (ClinicalTrial.gov: NCT01099137). PMID:26003889

  8. Ephedrine as add-on therapy for patients with myasthenia gravis: protocol for a series of randomised, placebo-controlled n-of-1 trials

    PubMed Central

    Vrinten, Charlotte; Lipka, Alexander F; van Zwet, Erik W; Schimmel, Kirsten J M; Cornel, Martina C; Kuijpers, Marja R; Hekster, Yechiel A; Weinreich, Stephanie S; Verschuuren, Jan J G M

    2015-01-01

    Introduction Myasthenia gravis (MG), a rare neuromuscular disease, is often initially treated using acetylcholinesterase inhibitors. Patients who do not respond adequately depend on the use of corticosteroids or other immunosuppressive medication, but these may have serious side effects. Clinical observations suggest that ephedrine can diminish, postpone or even prevent the need for immunosuppressive therapy when added to acetylcholinesterase inhibitors or low-dose prednisone. In the Netherlands, ephedrine is not licensed for MG nor is reimbursement guaranteed. MG is a rare condition, and ephedrine might be indicated only in a subset of patients. Thus, randomised controlled trials comparing large groups are difficult to conduct. We, therefore, aim to aggregate data from a small series of n-of-1 trials (also known as single patient trials) to assess the effect of ephedrine as add-on treatment for MG. Methods and analysis Single-centre, placebo-controlled, double-blind, randomised, multiple crossover n-of-1 studies in 4 adult patients with generalised MG who show inadequate improvement on pyridostigmine and/or immunosuppressive drugs. Each n-of-1 trial has 3 cycles of two 5-day intervention periods. Treatment: 25 mg ephedrine or placebo, twice daily. Main outcome measure: Quantitative Myasthenia Gravis (QMG) test. Statistical analysis: fixed effects linear model for QMG for all patients combined. Secondary outcome measures: Clinical: effects on MG-Composite and MG-Activities of Daily Living (MG-ADL) scales; QMG at individual level; adverse events. Acceptability of trial design: number of patients eligible and enrolled; number of treatment cycles completed; patients’ and caregivers’ experiences. Ethics and dissemination This study was approved by the Medical Ethics Committee of Leiden University Medical Center, No. P14.108. Results of the trial will be reported in a peer-reviewed publication. Regulatory stakeholders will comment on the suitability of the trial

  9. Acarbose improves glycemic control as add-on or monotherapy in Indian type-2 diabetes: Findings from the GlucoVIP multinational observational study

    PubMed Central

    Philip, Elizabeth; Sundaram, Meenakshi L.; Das, Rupam; Chauhan, Sushil Kumar; Deshpande, Sandeep; Ambhore, Sanjay; Rathod, Rahul; Manjrekar, Pravin

    2013-01-01

    Objective: To investigate the efficacy and tolerability of the anti-diabetic agent acarbose (Glucobay®) as add-on or monotherapy in a range of patients with type-2 diabetes mellitus (T2DM), including those with cardiovascular morbidities in India. Materials and Methods: This was a part of a prospective, non-interventional, non-controlled, multicentre, multinational, observational study. The study included patients of either gender if they were aged at least 18 years and had untreated or pre-treated type-2 diabetes mellitus (T2DM) or impaired glucose tolerance and no acarbose treatment within the 3 months before study inclusion. Results: In total, 1996 Indian patients were included in the effectiveness and 2010 in the safety analysis. Patients received acarbose (25-150 mg/day). The mean age of the patients was 50.1 years and the mean BMI was 27.2 kg/m2. Mean 2-h post-prandial plasma glucose (PPG) value and fasting blood glucose (FBG) decreased from 243.9 to 169.5 mg/dl and 158.3 to 120.4 mg/dl, respectively after the last follow-up of 12.4 weeks. The mean HbA1c value at initial visit was 8.4% and was 7.4% at the last follow-up visit. FBG, PPG and HbA1c deceased in 90.6%, 94.4% and 52.4% patients respectively, by the last follow-up visit. The mean decrease in weight and waist circumference was 1.4 kg and 1.6 cm, respectively by the last follow-up visit. Physicians assessed the efficacy of drug as positive response in “very good to good” in 91.08%, “sufficient” in 7.92% and “insufficient” in 0.90% of patients. Also, continuation of Acarbose was reported in 97.09% of patients. Adverse events were reported in 2.74% and drug-related adverse events were reported in 2.19% of patients. Majority of them were gastrointestinal adverse events but were not serious. Conclusion: Acarbose is effective and safe in Indian patients with T2DM. Further, it helps in weight reduction and has very good compliance in patients with T2DM. PMID:24910836

  10. 40 CFR 63.3966 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 1A of appendix A to 40 CFR part 60, as appropriate, to select sampling sites and velocity traverse points. (2) Use Method 2, 2A, 2C, 2D, 2F, or 2G of appendix A to 40 CFR part 60, as appropriate, to measure gas volumetric flow rate. (3) Use Method 3, 3A, or 3B of appendix A to 40 CFR part 60,...

  11. 40 CFR 63.3966 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 1A of appendix A to 40 CFR part 60, as appropriate, to select sampling sites and velocity traverse points. (2) Use Method 2, 2A, 2C, 2D, 2F, or 2G of appendix A to 40 CFR part 60, as appropriate, to measure gas volumetric flow rate. (3) Use Method 3, 3A, or 3B of appendix A to 40 CFR part 60,...

  12. 40 CFR 63.3966 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 1A of appendix A to 40 CFR part 60, as appropriate, to select sampling sites and velocity traverse points. (2) Use Method 2, 2A, 2C, 2D, 2F, or 2G of appendix A to 40 CFR part 60, as appropriate, to measure gas volumetric flow rate. (3) Use Method 3, 3A, or 3B of appendix A to 40 CFR part 60,...

  13. 40 CFR 63.3966 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 1A of appendix A to 40 CFR part 60, as appropriate, to select sampling sites and velocity traverse points. (2) Use Method 2, 2A, 2C, 2D, 2F, or 2G of appendix A to 40 CFR part 60, as appropriate, to measure gas volumetric flow rate. (3) Use Method 3, 3A, or 3B of appendix A to 40 CFR part 60,...

  14. 40 CFR 63.3966 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 1A of appendix A to 40 CFR part 60, as appropriate, to select sampling sites and velocity traverse points. (2) Use Method 2, 2A, 2C, 2D, 2F, or 2G of appendix A to 40 CFR part 60, as appropriate, to measure gas volumetric flow rate. (3) Use Method 3, 3A, or 3B of appendix A to 40 CFR part 60,...

  15. 40 CFR 63.3166 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) through (5) of this section. (1) Use Method 1 or 1A of appendix A to 40 CFR part 60, as appropriate, to... to 40 CFR part 60, as appropriate, to measure gas volumetric flow rate. (3) Use Method 3, 3A, or 3B of appendix A to 40 CFR part 60, as appropriate, for gas analysis to determine dry molecular...

  16. 40 CFR 63.3166 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) through (5) of this section. (1) Use Method 1 or 1A of appendix A to 40 CFR part 60, as appropriate, to... to 40 CFR part 60, as appropriate, to measure gas volumetric flow rate. (3) Use Method 3, 3A, or 3B of appendix A to 40 CFR part 60, as appropriate, for gas analysis to determine dry molecular...

  17. 40 CFR 63.3166 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) through (5) of this section. (1) Use Method 1 or 1A of appendix A to 40 CFR part 60, as appropriate, to... to 40 CFR part 60, as appropriate, to measure gas volumetric flow rate. (3) Use Method 3, 3A, or 3B of appendix A to 40 CFR part 60, as appropriate, for gas analysis to determine dry molecular...

  18. 40 CFR Table 1 to Subpart IIIi of... - Operating Limits for Capture Systems and Add-On Control Devices

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... of appendix M to 40 CFR part 51 i. Collecting the direction of air flow, and either the facial... Pollutants: Surface Coating of Automobiles and Light-Duty Trucks Pt. 63, Subpt. IIII, Table 1 Table 1...

  19. 40 CFR Table 1 to Subpart IIIi of... - Operating Limits for Capture Systems and Add-On Control Devices

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... of appendix M to 40 CFR part 51 i. Collecting the direction of air flow, and either the facial... Pollutants: Surface Coating of Automobiles and Light-Duty Trucks Pt. 63, Subpt. IIII, Table 1 Table 1...

  20. 40 CFR 63.4766 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... (a)(1) through (5) of this section. (1) Use Method 1 or 1A of appendix A to 40 CFR part 60, as... appendix A to 40 CFR part 60, as appropriate, to measure gas volumetric flow rate. (3) Use Method 3, 3A, or 3B of appendix A to 40 CFR part 60, as appropriate, for gas analysis to determine dry...

  1. 40 CFR 63.4965 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) through (5) of this section. (1) Use Method 1 or 1A of appendix A to 40 CFR part 60, as appropriate, to... to 40 CFR part 60, as appropriate, to measure gas volumetric flow rate. (3) Use Method 3, 3A, or 3B of appendix A to 40 CFR part 60, as appropriate, for gas analysis to determine dry molecular...

  2. 40 CFR 63.4965 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) through (5) of this section. (1) Use Method 1 or 1A of appendix A to 40 CFR part 60, as appropriate, to... to 40 CFR part 60, as appropriate, to measure gas volumetric flow rate. (3) Use Method 3, 3A, or 3B of appendix A to 40 CFR part 60, as appropriate, for gas analysis to determine dry molecular...

  3. 40 CFR 63.4766 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) of this section. (1) Use Method 1 or 1A of appendix A to 40 CFR part 60, as appropriate, to select... CFR part 60, as appropriate, to measure gas volumetric flow rate. (3) Use Method 3, 3A, or 3B of appendix A to 40 CFR part 60, as appropriate, for gas analysis to determine dry molecular weight. You...

  4. 40 CFR 63.3545 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) of this section. (1) Use Method 1 or 1A of appendix A to 40 CFR part 60, as appropriate, to select... CFR part 60, as appropriate, to measure gas volumetric flow rate. (3) Use Method 3, 3A, or 3B of appendix A to 40 CFR part 60, as appropriate, for gas analysis to determine dry molecular weight. You...

  5. 40 CFR 63.4766 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... (a)(1) through (5) of this section. (1) Use Method 1 or 1A of appendix A to 40 CFR part 60, as... appendix A to 40 CFR part 60, as appropriate, to measure gas volumetric flow rate. (3) Use Method 3, 3A, or 3B of appendix A to 40 CFR part 60, as appropriate, for gas analysis to determine dry...

  6. 40 CFR 63.4166 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...)(1) through (5) of this section. (1) Use Method 1 or 1A of appendix A to 40 CFR part 60, as... appendix A to 40 CFR part 60, as appropriate, to measure gas volumetric flow rate. (3) Use Method 3, 3A, or 3B of appendix A to 40 CFR part 60, as appropriate, for gas analysis to determine dry...

  7. 40 CFR 63.4166 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) of this section. (1) Use Method 1 or 1A of appendix A to 40 CFR part 60, as appropriate, to select... CFR part 60, as appropriate, to measure gas volumetric flow rate. (3) Use Method 3, 3A, or 3B of appendix A to 40 CFR part 60, as appropriate, for gas analysis to determine dry molecular weight. You...

  8. 40 CFR 63.4965 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... section. (1) Use Method 1 or 1A of appendix A to 40 CFR part 60, as appropriate, to select sampling sites and velocity traverse points. (2) Use Method 2, 2A, 2C, 2D, 2F, or 2G of appendix A to 40 CFR part 60... CFR part 60, as appropriate, for gas analysis to determine dry molecular weight. You may also use...

  9. 40 CFR 63.4166 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...)(1) through (5) of this section. (1) Use Method 1 or 1A of appendix A to 40 CFR part 60, as... appendix A to 40 CFR part 60, as appropriate, to measure gas volumetric flow rate. (3) Use Method 3, 3A, or 3B of appendix A to 40 CFR part 60, as appropriate, for gas analysis to determine dry...

  10. 40 CFR 63.3545 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) of this section. (1) Use Method 1 or 1A of appendix A to 40 CFR part 60, as appropriate, to select... CFR part 60, as appropriate, to measure gas volumetric flow rate. (3) Use Method 3, 3A, or 3B of appendix A to 40 CFR part 60, as appropriate, for gas analysis to determine dry molecular weight. You...

  11. 40 CFR 63.4362 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... appendix A to 40 CFR part 60, as appropriate, to measure gas volumetric flow rate. (3) Use Method 3, 3A, or....4350. You must conduct three test runs as specified in § 63.7(e)(3) and each test run must last at... paragraphs (a)(1) through (5) of this section. (1) Use Method 1 or 1A of appendix A to 40 CFR part 60,...

  12. 40 CFR 63.4362 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... appendix A to 40 CFR part 60, as appropriate, to measure gas volumetric flow rate. (3) Use Method 3, 3A, or....4350. You must conduct three test runs as specified in § 63.7(e)(3) and each test run must last at... paragraphs (a)(1) through (5) of this section. (1) Use Method 1 or 1A of appendix A to 40 CFR part 60,...

  13. 40 CFR 63.4362 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... appendix A to 40 CFR part 60, as appropriate, to measure gas volumetric flow rate. (3) Use Method 3, 3A, or....4350. You must conduct three test runs as specified in § 63.7(e)(3) and each test run must last at... paragraphs (a)(1) through (5) of this section. (1) Use Method 1 or 1A of appendix A to 40 CFR part 60,...

  14. 40 CFR 63.4362 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... appendix A to 40 CFR part 60, as appropriate, to measure gas volumetric flow rate. (3) Use Method 3, 3A, or....4350. You must conduct three test runs as specified in § 63.7(e)(3) and each test run must last at... paragraphs (a)(1) through (5) of this section. (1) Use Method 1 or 1A of appendix A to 40 CFR part 60,...

  15. 40 CFR Table 1 to Subpart IIIi of... - Operating Limits for Capture Systems and Add-On Control Devices

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... desorbing gas (e.g., steam or nitrogen) mass flow for each carbon bed regeneration cycle must not fall below... of appendix M to 40 CFR part 51 i. Collecting the direction of air flow, and either the facial.... Measuring the total regeneration desorbing gas (e.g., steam or nitrogen) mass flow for each...

  16. 40 CFR 63.9323 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    .... (1) Use Method 1 or 1A of appendix A to 40 CFR part 60, as appropriate, to select sampling sites and velocity traverse points. (2) Use Method 2, 2A, 2C, 2D, 2F, or 2G of appendix A to 40 CFR part 60, as appropriate, to measure gas volumetric flow rate. (3) Use Method 3, 3A, or 3B of appendix A to 40 CFR part...

  17. 40 CFR 63.4766 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., carbon dioxide, and carbon monoxide content of exhaust gas in ANSI/ASME PTC 19.10-1981, “Flue and Exhaust... (a)(1) through (5) of this section. (1) Use Method 1 or 1A of appendix A to 40 CFR part 60, as... appendix A to 40 CFR part 60, as appropriate, to measure gas volumetric flow rate. (3) Use Method 3, 3A,...

  18. 40 CFR 63.4965 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... dioxide, and carbon monoxide content of exhaust gas in ANSI/ASME PTC 19.10-1981, “Flue and Exhaust Gas...) through (5) of this section. (1) Use Method 1 or 1A of appendix A to 40 CFR part 60, as appropriate, to... to 40 CFR part 60, as appropriate, to measure gas volumetric flow rate. (3) Use Method 3, 3A, or...

  19. 40 CFR 63.4766 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... also use as an alternative to Method 3B, the manual method for measuring the oxygen, carbon dioxide...) of this section. (1) Use Method 1 or 1A of appendix A to 40 CFR part 60, as appropriate, to select... CFR part 60, as appropriate, to measure gas volumetric flow rate. (3) Use Method 3, 3A, or 3B...

  20. 40 CFR 63.3545 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... an alternative to Method 3B the manual method for measuring the oxygen, carbon dioxide, and carbon... section. (1) Use Method 1 or 1A of appendix A to 40 CFR part 60, as appropriate, to select sampling sites and velocity traverse points. (2) Use Method 2, 2A, 2C, 2D, 2F, or 2G of appendix A to 40 CFR part...

  1. 40 CFR 63.3545 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... also use as an alternative to Method 3B the manual method for measuring the oxygen, carbon dioxide, and...) of this section. (1) Use Method 1 or 1A of appendix A to 40 CFR part 60, as appropriate, to select... CFR part 60, as appropriate, to measure gas volumetric flow rate. (3) Use Method 3, 3A, or 3B...

  2. 40 CFR 63.4166 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., carbon dioxide, and carbon monoxide content of exhaust gas in ANSI/ASME, PTC 19.10-1981, “Flue and...)(1) through (5) of this section. (1) Use Method 1 or 1A of appendix A to 40 CFR part 60, as... appendix A to 40 CFR part 60, as appropriate, to measure gas volumetric flow rate. (3) Use Method 3, 3A,...

  3. 40 CFR 63.3545 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... an alternative to Method 3B the manual method for measuring the oxygen, carbon dioxide, and carbon... section. (1) Use Method 1 or 1A of appendix A to 40 CFR part 60, as appropriate, to select sampling sites and velocity traverse points. (2) Use Method 2, 2A, 2C, 2D, 2F, or 2G of appendix A to 40 CFR part...

  4. 40 CFR 63.4166 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... also use as an alternative to Method 3B, the manual method for measuring the oxygen, carbon dioxide...) of this section. (1) Use Method 1 or 1A of appendix A to 40 CFR part 60, as appropriate, to select... CFR part 60, as appropriate, to measure gas volumetric flow rate. (3) Use Method 3, 3A, or 3B...

  5. 40 CFR 63.4965 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... an alternative to Method 3B, the manual method for measuring the oxygen, carbon dioxide, and carbon... section. (1) Use Method 1 or 1A of appendix A to 40 CFR part 60, as appropriate, to select sampling sites and velocity traverse points. (2) Use Method 2, 2A, 2C, 2D, 2F, or 2G of appendix A to 40 CFR part...

  6. 40 CFR Table 1 to Subpart Ssss of... - Operating Limits if Using Add-on Control Devices and Capture System

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... the catalyst bed in any 3-hour period must not fall below the limit established according to § 63.5160... catalyst bed at or above the temperature limit. b. ensure that the average temperature difference across the catalyst bed in any 3-hour period does not fall below the temperature difference limit...

  7. 40 CFR Table 2 to Subpart Oooo of... - Operating Limits if Using Add-On Control Devices and Capture System

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... the catalyst bed in any 3-hour block period must not fall below the limit established according to... data to 3-hour block averages; and iii. maintaining the 3-hour block average catalyst bed inlet... catalyst bed in any 3-hour block period does not fall below the temperature difference limit...

  8. 40 CFR Table 2 to Subpart Oooo of... - Operating Limits if Using Add-On Control Devices and Capture System

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... the catalyst bed in any 3-hour block period must not fall below the limit established according to... data to 3-hour block averages; and iii. maintaining the 3-hour block average catalyst bed inlet... catalyst bed in any 3-hour block period does not fall below the temperature difference limit...

  9. 40 CFR Table 1 to Subpart Jjjj of... - Operating Limits if Using Add-On Control Devices and Capture System

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... catalyst bed in any 3-hour period must not fall below the combustion temperature limit established according to § 63.3360(e)(3)(ii) i. Collecting the catalyst bed inlet temperature data according to § 63... catalyst bed inlet temperature at or above the temperature limit. b. The temperature rise across...

  10. 40 CFR Table 1 to Subpart Jjjj of... - Operating Limits if Using Add-On Control Devices and Capture System

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    .... Catalytic oxidizer a. The average temperature at the inlet to the catalyst bed in any 3-hour period must not... the catalyst bed inlet temperature data according to § 63.3350(e)(9);ii. Reducing the data to 3-hour block averages; and iii. Maintain the 3-hour average catalyst bed inlet temperature at or above...

  11. 40 CFR Table 1 to Subpart Ssss of... - Operating Limits if Using Add-on Control Devices and Capture System

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... before the catalyst bed in any 3-hour period must not fall below the limit established according to § 63... catalyst bed at or above the temperature limit. b. ensure that the average temperature difference across the catalyst bed in any 3-hour period does not fall below the temperature difference limit...

  12. 40 CFR Table 1 to Subpart Jjjj of... - Operating Limits if Using Add-On Control Devices and Capture System

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... catalyst bed in any 3-hour period must not fall below the combustion temperature limit established according to § 63.3360(e)(3)(ii) i. Collecting the catalyst bed inlet temperature data according to § 63... catalyst bed inlet temperature at or above the temperature limit. b. The temperature rise across...

  13. 40 CFR Table 2 to Subpart Oooo of... - Operating Limits if Using Add-On Control Devices and Capture System

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... the catalyst bed in any 3-hour block period must not fall below the limit established according to... data to 3-hour block averages; and iii. maintaining the 3-hour block average catalyst bed inlet... catalyst bed in any 3-hour block period does not fall below the temperature difference limit...

  14. 40 CFR Table 2 to Subpart Oooo of... - Operating Limits if Using Add-On Control Devices and Capture System

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... the catalyst bed in any 3-hour block period must not fall below the limit established according to... data to 3-hour block averages; and iii. maintaining the 3-hour block average catalyst bed inlet... catalyst bed in any 3-hour block period does not fall below the temperature difference limit...

  15. 40 CFR Table 1 to Subpart Jjjj of... - Operating Limits if Using Add-On Control Devices and Capture System

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    .... Catalytic oxidizer a. The average temperature at the inlet to the catalyst bed in any 3-hour period must not... the catalyst bed inlet temperature data according to § 63.3350(e)(9);ii. Reducing the data to 3-hour block averages; and iii. Maintain the 3-hour average catalyst bed inlet temperature at or above...

  16. 40 CFR Table 1 to Subpart Jjjj of... - Operating Limits if Using Add-On Control Devices and Capture System

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... catalyst bed in any 3-hour period must not fall below the combustion temperature limit established according to § 63.3360(e)(3)(ii) i. Collecting the catalyst bed inlet temperature data according to § 63... catalyst bed inlet temperature at or above the temperature limit. b. The temperature rise across...

  17. 40 CFR Table 1 to Subpart Ssss of... - Operating Limits if Using Add-on Control Devices and Capture System

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... before the catalyst bed in any 3-hour period must not fall below the limit established according to § 63... catalyst bed at or above the temperature limit. b. ensure that the average temperature difference across the catalyst bed in any 3-hour period does not fall below the temperature difference limit...

  18. 40 CFR Table 2 to Subpart Oooo of... - Operating Limits if Using Add-On Control Devices and Capture System

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... the catalyst bed in any 3-hour block period must not fall below the limit established according to... data to 3-hour block averages; and iii. maintaining the 3-hour block average catalyst bed inlet... catalyst bed in any 3-hour block period does not fall below the temperature difference limit...

  19. 40 CFR Table 1 to Subpart Ssss of... - Operating Limits if Using Add-on Control Devices and Capture System

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... the catalyst bed in any 3-hour period must not fall below the limit established according to § 63.5160... catalyst bed at or above the temperature limit. b. ensure that the average temperature difference across the catalyst bed in any 3-hour period does not fall below the temperature difference limit...

  20. 40 CFR Table 1 to Subpart Ssss of... - Operating Limits if Using Add-on Control Devices and Capture System

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... before the catalyst bed in any 3-hour period must not fall below the limit established according to § 63... catalyst bed at or above the temperature limit. b. ensure that the average temperature difference across the catalyst bed in any 3-hour period does not fall below the temperature difference limit...

  1. 40 CFR 63.4362 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... paragraphs (a)(1) through (5) of this section. (1) Use Method 1 or 1A of appendix A to 40 CFR part 60, as... appendix A to 40 CFR part 60, as appropriate, to measure gas volumetric flow rate. (3) Use Method 3, 3A, or 3B of appendix A to 40 CFR part 60, as appropriate, for gas analysis to determine dry...

  2. 40 CFR Table 1 to Subpart IIIi of... - Operating Limits for Capture Systems and Add-On Control Devices

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... of appendix M to 40 CFR part 51 i. Collecting the direction of air flow, and either the facial... annual catalyst activity checks, records of monthly inspections of the oxidizer system, and records of... average temperature at or above the temperature limit. 6. Emission capture system that is a PTE a....

  3. 40 CFR 63.4566 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... to 40 CFR part 60, as appropriate, to measure gas volumetric flow rate. (3) Use Method 3, 3A, or 3B of appendix A to 40 CFR part 60, as appropriate, for gas analysis to determine dry molecular weight...) through (5) of this section. (1) Use Method 1 or 1A of appendix A to 40 CFR part 60, as appropriate,...

  4. 40 CFR 63.3166 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) of this section. (1) Use Method 1 or 1A of appendix A to 40 CFR part 60, as appropriate, to select... CFR part 60, as appropriate, to measure gas volumetric flow rate. (3) Use Method 3, 3A, or 3B of appendix A to 40 CFR part 60, as appropriate, for gas analysis to determine dry molecular weight. The...

  5. 40 CFR 63.3166 - How do I determine the add-on control device emission destruction or removal efficiency?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) of this section. (1) Use Method 1 or 1A of appendix A to 40 CFR part 60, as appropriate, to select... CFR part 60, as appropriate, to measure gas volumetric flow rate. (3) Use Method 3, 3A, or 3B of appendix A to 40 CFR part 60, as appropriate, for gas analysis to determine dry molecular weight. The...

  6. REACTOR CONTROL DEVICE

    DOEpatents

    Kaufman, H.B.; Weiss, A.A.

    1959-08-18

    A shadow control device for controlling a nuclear reactor is described. The device comprises a series of hollow neutron-absorbing elements arranged in groups, each element having a cavity for substantially housing an adjoining element and a longitudinal member for commonly supporting the groups of elements. Longitudinal actuation of the longitudinal member distributes the elements along its entire length in which position maximum worth is achieved.

  7. Device control at CEBAF

    SciTech Connect

    Schaffner, S.; Barker, D.; Bookwalter, V.

    1996-08-01

    CEBAF has undergone a major conversion of its accelerator control system from TACL to EPICS, affecting device control for the RF system, magnets, the machine protection system, the vacuum and valves, and the diagnostic systems including beam position monitors, harps, and the camera and solenoid devices (beam viewers, faraday cups, optical transition radiation viewers, synchrotron radiation monitor, etc.). Altogether these devices require approximately 125,000 EPICS database records. The majority of these devices are controlled through CAMAC; some use embedded microprocessors (RF and magnets), and newer interfaces are in VME. The standard EPICS toolkit was extended to include a driver for CAMAC which supports dual processors on one serial highway, custom database records for magnets and BPMs, and custom data acquisition tasks for the BPMs. 2 refs., 1 tab.

  8. Device Oriented Project Controller

    SciTech Connect

    Dalesio, Leo; Kraimer, Martin

    2013-11-20

    This proposal is directed at the issue of developing control systems for very large HEP projects. A de-facto standard in accelerator control is the Experimental Physics and Industrial Control System (EPICS), which has been applied successfully to many physics projects. EPICS is a channel based system that requires that each channel of each device be configured and controlled. In Phase I, the feasibility of a device oriented extension to the distributed channel database was demonstrated by prototyping a device aware version of an EPICS I/O controller that functions with the current version of the channel access communication protocol. Extensions have been made to the grammar to define the database. Only a multi-stage position controller with limit switches was developed in the demonstration, but the grammar should support a full range of functional record types. In phase II, a full set of record types will be developed to support all existing record types, a set of process control functions for closed loop control, and support for experimental beam line control. A tool to configure these records will be developed. A communication protocol will be developed or extensions will be made to Channel Access to support introspection of components of a device. Performance bench marks will be made on both communication protocol and the database. After these records and performance tests are under way, a second of the grammar will be undertaken.

  9. Contamination control device

    DOEpatents

    Clark, Robert M.; Cronin, John C.

    1977-01-01

    A contamination control device for use in a gas-insulated transmission bus consisting of a cylindrical center conductor coaxially mounted within a grounded cylindrical enclosure. The contamination control device is electrically connected to the interior surface of the grounded outer shell and positioned along an axial line at the lowest vertical position thereon. The contamination control device comprises an elongated metallic member having a generally curved cross-section in a first plane perpendicular to the axis of the bus and having an arcuate cross-section in a second plane lying along the axis of the bus. Each opposed end of the metallic member and its opposing sides are tapered to form a pair of generally converging and downward sloping surfaces to trap randomly moving conductive particles in the relatively field-free region between the metallic member and the interior surface of the grounded outer shell. The device may have projecting legs to enable the device to be spot welded to the interior of the grounded housing. The control device provides a high capture probability and prevents subsequent release of the charged particles after the capture thereof.

  10. REACTOR CONTROL DEVICE

    DOEpatents

    Graham, R.H.

    1962-09-01

    A wholly mechanical compact control device is designed for automatically rendering the core of a fission reactor subcritical in response to core temperatures in excess of the design operating temperature limit. The control device comprises an expansible bellows interposed between the base of a channel in a reactor core and the inner end of a fuel cylinder therein which is normally resiliently urged inwardly. The bellows contains a working fluid which undergoes a liquid to vapor phase change at a temperature substantially equal to the design temperature limit. Hence, the bellows abruptiy expands at this limiting temperature to force the fuel cylinder outward and render the core subcritical. The control device is particularly applicable to aircraft propulsion reactor service. (AEC)

  11. Rapid response to methylphenidate as an add-on therapy to mirtazapine in the treatment of major depressive disorder in terminally ill cancer patients: a four-week, randomized, double-blinded, placebo-controlled study.

    PubMed

    Ng, Chong Guan; Boks, Marco P M; Roes, Kit C B; Zainal, Nor Zuraida; Sulaiman, Ahmad Hatim; Tan, Seng Beng; de Wit, Niek J

    2014-04-01

    This is a 4 week, randomized, double-blind, placebo-controlled study to examine the effects of methylphenidate as add-on therapy to mirtazapine compared to placebo for treatment of depression in terminally ill cancer patients. It involved 88 terminally ill cancer patients from University of Malaya Medical Centre, Kuala Lumpur, Malaysia. They were randomized and treated with either methylphenidate or placebo as add on to mirtazapine. The change in Montgomery-Åsberg Depression Rating Scale (MADRS) score from baseline to day 3 was analyzed by linear regression. Changes of MADRS and Clinical Global Impression-Severity Scale (CGI-S) over 28 days were analyzed using mixed model repeated measures (MMRM). Secondary analysis of MADRS response rates, defined as 50% or more reduction from baseline score. A significantly larger reduction of Montgomery-Åsberg Depression Rating Scale (MADRS) score in the methylphenidate group was observed from day 3 (B=4.14; 95% CI=1.83-6.45). Response rate (defined as 50% or more reduction from baseline MADRS score) in the methylphenidate treated group was superior from day 14. Improvement in Clinical Global Impression-Severity Scale (CGI-S) was greater in the methylphenidate treated group from day 3 until day 28. The drop-out rates were 52.3% in the methylphenidate group and 59.1% in the placebo group (relative risk=0.86, 95%CI=0.54-1.37) due to cancer progression. Nervous system adverse events were more common in methylphenidate treated subjects (20.5% vs 9.1%, p=0.13). In conclusions, methylphenidate as add on therapy to mirtazapine demonstrated an earlier antidepressant response in terminally ill cancer patients, although at an increased risk of the nervous system side effects. PMID:24503279

  12. Radiographic quality control devices.

    PubMed

    2000-04-01

    In this study, we evaluate eight radiographic quality control (QC) devices, which noninvasively measure the output from a variety of diagnostic x-ray production systems. When used as part of a quality assurance (QA) program, radiographic QC devices help ensure that x-ray equipment is working within acceptable limits. This in turn helps ensure that high-quality images are achieved with appropriate radiation doses and that resources are used efficiently (for example, by minimizing the number of repeat exposures required). Our testing focused on the physical performance, ease of use, and service and maintenance characteristics that affect the use of these devices for periodic, routine measurements of x-ray system parameters. We found that all the evaluated models satisfactorily measure all the parameters normally needed for a QA program. However, we did identify a number of differences among the models--particularly in the range of exposure levels that can be effectively measured and the ease of use. Three models perform well for a variety of applications and are very easy to use; we rate them Preferred. Three additional models have minor limitations but otherwise perform well; we rate them Acceptable. We recommend against purchasing two models because, although each performs acceptably for most applications, neither model can measure low levels of radiation. This Evaluation covers devices designed to measure the output of x-ray tubes noninvasively. These devices, called radiographic quality control (QC) devices, or QC meters, are typically used by medical physicists, x-ray engineers, biomedical engineers, and suitably trained radiographic technologists to make QC measurements. We focus on the use of these devices as part of an overall quality assurance (QA) program. We have not evaluated their use for other applications, such as acceptance testing. To be included in this study, a device must be able to measure the exposure- and kVp-related characteristics of most x

  13. Contaminate Control Device

    NASA Technical Reports Server (NTRS)

    Howe, Robert H. (Inventor); Flynn, Kenneth P. (Inventor); Stapleton, Thomas J. (Inventor)

    2014-01-01

    A contaminate control device for filtering contaminates from a gas such as air is provided. The device includes a housing having a first inlet and a first outlet. An axial flow filter is fluidly coupled between the first inlet and the first outlet, the axial flow filter has a second inlet and a second outlet. A second filter disposed about the axial flow filter and is fluidly coupled between the first inlet and the first outlet, the second filter having a third inlet on an inner diameter and a third outlet disposed on an outer diameter. A flow restrictor is fluidly coupled between the second inlet and the first inlet.

  14. REMOTE CONTROLLED SWITCHING DEVICE

    DOEpatents

    Hobbs, J.C.

    1959-02-01

    An electrical switching device which can be remotely controlled and in which one or more switches may be accurately operated at predetermined times or with predetermined intervening time intervals is described. The switching device consists essentially of a deck, a post projecting from the deck at right angles thereto, cam means mounted for rotation around said posts and a switch connected to said deck and actuated by said cam means. Means is provided for rotating the cam means at a constant speed and the switching apparatus is enclosed in a sealed container with external adjusting means and electrical connection elements.

  15. Firefox add-ons for medical reference.

    PubMed

    Hoy, Matthew B

    2010-07-01

    Firefox is a Web browser created by the Mozilla project, an open-source software group. Features of the browser include automated updates, advanced security and standards compliance, and the ability to add functionality through add-ons and extensions. First introduced in 2004, Firefox now accounts for roughly 30% of the browser market. This article will focus primarily on add-ons and extensions available for the browser that are useful to medical researchers. PMID:20677067

  16. 12-Week, Placebo-Controlled Trial of Add-on Riluzole in the Treatment of Childhood-Onset Obsessive–Compulsive Disorder

    PubMed Central

    Grant, Paul J; Joseph, Lisa A; Farmer, Cristan A; Luckenbaugh, David A; Lougee, Lorraine C; Zarate, Carlos A; Swedo, Susan E

    2014-01-01

    Many children with childhood-onset obsessive–compulsive disorder (OCD) fail to respond adequately to standard therapies. Evidence from preclinical and clinical studies suggests that the glutamatergic neurotransmitter system might be an alternative treatment target. This study examined the efficacy of riluzole, a glutamatergic modulator, as an adjunctive therapy for children with treatment-resistant OCD. In a 12-week, double-blind, placebo-controlled study, 60 treatment-resistant children and adolescents (mean age=14.5±2.4 years), with moderate to severe OCD (mean Children's Yale-Brown Obsessive–Compulsive Scale (CY-BOCS)=28.2±3.7), 17 of whom also had concomitant autism spectrum disorder, were randomized to receive riluzole (final dose of 100 mg/day) or placebo in addition to the existing treatment regimen. Fifty-nine subjects completed the randomized trial. Primary outcome measures were changes on the CY-BOCS, the Clinical Global Impressions Scale, and the Children's Global Assessment Scale. Riluzole was fairly well tolerated, although it was associated with one case of pancreatitis and five instances of slight increases in transaminases. All subjects showed significant reductions in CY-BOCS scores during treatment; however, there was no significant difference between placebo and riluzole on any of the primary or secondary outcome measures. The study failed to demonstrate superiority of riluzole over placebo as an adjunctive treatment for children with childhood-onset OCD. However, future studies may show benefits for less treatment-refractory children with fewer concomitant medications. PMID:24356715

  17. Controllable Mirror Devices

    NASA Technical Reports Server (NTRS)

    1992-01-01

    A deformable Mirror Device (DMD) is a type of spatial light modulator in which mirrors fabricated monolithically on a silicon chip are deformed, or tilted, under electronic control to change the direction of light that falls upon the mirror. NASA and Texas Instruments (TI) have worked to develop this technology, which has subsequently been commercialized by TI. Initial application is the DMD 2000 Travel Information Printer for high speed, high volume printing of airline tickets and boarding passes. Other possible applications range from real-time object tracking to advanced industrial machine vision systems.

  18. A Single-blind, Placebo-controlled, Dose-ranging Trial of Oral Hepatic-directed Vesicle Insulin Add-on to Oral Antidiabetic Treatment in Patients With Type 2 Diabetes Mellitus

    PubMed Central

    Rosenberg, Len N.; Schwartz, Sherwyn L.; Lau, John R.; Gana, Theophilus J.

    2014-01-01

    The dose response of postprandial plasma glucose (PPG) to add-on, premeal oral hepatic-directed vesicle-insulin (HDV-I), an investigational lipid bio-nanoparticle hepatocyte-targeted insulin delivery system, was evaluated in a 3-test-meal/day model in type 2 diabetes patients. The single-blind, placebo-controlled, dose-escalating trial enrolled 6 patients with HbA1c 8.6 ± 2.0% (70.0 ± 21.9 mmol/mol) and on stable metformin therapy. Patients received oral HDV-I capsules daily 30 minutes before breakfast, lunch, and dinner as follows: placebo capsules, 0.05, 0.1, 0.2, and 0.4 U/kg on days 1, 2, 3, 4, and 5, respectively. Outcome measures were PPG and incremental PPG area under the concentration-time curve (AUC). All 4 doses of oral HDV-I statistically significantly lowered mean PPG (P ≤ .0110 each) and incremental PPG (P ≤ .0352 each) AUC compared to placebo. A linear dose response was not observed. The 0.05 U/kg dose was the minimum effective dose in the dosage range studied. Three adverse events unrelated to treatment were observed. Add-on oral HDV-I 0.05-0.4 U/kg significantly lowered PPG excursions and the dose response curve was flat. These results are consistent with the lack of a linear dose response between portal and systemic plasma insulin concentrations in previous animal and human studies. Oral HDV-I was safe and well tolerated. PMID:24876619

  19. Add-on unidirectional elastic metamaterial plate cloak

    PubMed Central

    Lee, Min Kyung; Kim, Yoon Young

    2016-01-01

    Metamaterial cloaks control the propagation of waves to make an object invisible or insensible. To manipulate elastic waves in space, a metamaterial cloak is typically embedded in a base system that includes or surrounds a target object. The embedding is undesirable because it structurally weakens or permanently alters the base system. In this study, we propose a new add-on metamaterial elastic cloak that can be placed over and mechanically coupled with a base structure without embedding. We designed an add-on type annular metamaterial plate cloak through conformal mapping, fabricated it and performed cloaking experiments in a thin-plate with a hole. Experiments were performed in a thin plate by using the lowest symmetric Lamb wave centered at 100 kHz. As a means to check the cloaking performance of the add-on elastic plate cloak, possibly as a temporary stress reliever or a so-called “stress bandage”, the degree of stress concentration mitigation and the recovery from the perturbed wave field due to a hole were investigated. PMID:26860896

  20. Add-on unidirectional elastic metamaterial plate cloak

    NASA Astrophysics Data System (ADS)

    Lee, Min Kyung; Kim, Yoon Young

    2016-02-01

    Metamaterial cloaks control the propagation of waves to make an object invisible or insensible. To manipulate elastic waves in space, a metamaterial cloak is typically embedded in a base system that includes or surrounds a target object. The embedding is undesirable because it structurally weakens or permanently alters the base system. In this study, we propose a new add-on metamaterial elastic cloak that can be placed over and mechanically coupled with a base structure without embedding. We designed an add-on type annular metamaterial plate cloak through conformal mapping, fabricated it and performed cloaking experiments in a thin-plate with a hole. Experiments were performed in a thin plate by using the lowest symmetric Lamb wave centered at 100 kHz. As a means to check the cloaking performance of the add-on elastic plate cloak, possibly as a temporary stress reliever or a so-called “stress bandage”, the degree of stress concentration mitigation and the recovery from the perturbed wave field due to a hole were investigated.

  1. Add-on unidirectional elastic metamaterial plate cloak.

    PubMed

    Lee, Min Kyung; Kim, Yoon Young

    2016-01-01

    Metamaterial cloaks control the propagation of waves to make an object invisible or insensible. To manipulate elastic waves in space, a metamaterial cloak is typically embedded in a base system that includes or surrounds a target object. The embedding is undesirable because it structurally weakens or permanently alters the base system. In this study, we propose a new add-on metamaterial elastic cloak that can be placed over and mechanically coupled with a base structure without embedding. We designed an add-on type annular metamaterial plate cloak through conformal mapping, fabricated it and performed cloaking experiments in a thin-plate with a hole. Experiments were performed in a thin plate by using the lowest symmetric Lamb wave centered at 100 kHz. As a means to check the cloaking performance of the add-on elastic plate cloak, possibly as a temporary stress reliever or a so-called "stress bandage", the degree of stress concentration mitigation and the recovery from the perturbed wave field due to a hole were investigated. PMID:26860896

  2. The Efficacy and Safety of Chinese Herbal Medicine Jinlida as Add-On Medication in Type 2 Diabetes Patients Ineffectively Managed by Metformin Monotherapy: A Double-Blind, Randomized, Placebo-Controlled, Multicenter Trial

    PubMed Central

    Lian, Fengmei; Tian, Jiaxing; Chen, Xinyan; Li, Zhibin; Piao, Chunli; Guo, Junjie; Ma, Licheng; Zhao, Lijuan; Xia, Chengdong; Wang, Chong-Zhi; Yuan, Chun-Su; Tong, Xiaolin

    2015-01-01

    Background Metformin plays an important role in diabetes treatment. Studies have shown that the combined use of oral hypoglycemic medications is more effective than metformin monotherapy. In this double-blind, randomized, placebo-controlled, multicenter trial, we evaluated whether Jinlida, a Chinese herbal medicine, enhances the glycemic control of metformin in type 2 diabetes patients whose HbA1c was ineffectively controlled with metformin alone. Methods A total of 186 diabetes patients were enrolled in this double-Blind, randomized, placebo-controlled, multicenter trial. Subjects were randomly allocated to receive either Jinlida (9 g) or the placebo TID for 12 consecutive weeks. All subjects in both groups also continuously received their metformin without any dose change. During this 12-week period, the HbA1c, FPG, 2h PG, body weight, BMI were assessed. HOMA insulin resistance (HOMA-IR) and β-cell function (HOMA- β) were also evaluated. Results At week 12, compared to the HbA1c level from week 0, the level of the Jinlida group was reduced by 0.92 ± 1.09% and that of the placebo group was reduced by 0.53 ± 0.94%. The 95% CI was 0.69 - 1.14 for the Jinlida group vs. 0.34 - 0.72 for the placebo group. There was a very significant HbA1c reduction between the two groups after 12 weeks (p < 0.01). Both FG and 2h PG levels of the Jinlida group and placebo group were reduced from week 0. There were a very significant FG and 2h PG level reductions between the two groups after 12 weeks (both p < 0.01). The Jinlida group also showed improved β-cell function with a HOMA-β increase (p < 0.05). No statistical significance was observed in the body weight and BMI changes. No serious adverse events were reported. Conclusion Jinlida significantly enhanced the hypoglycemic action of metformin when the drug was used alone. This Chinese herbal medicine may have a clinical value as an add-on medication to metformin monotherapy. Trial Registration Chinese Clinical Trial Register

  3. Fuel-air control device

    SciTech Connect

    Norman, J.

    1981-12-15

    The invention concerns a device for controlling the vehicles fuel-air mixture by regulating the air in the ventilation passage leading to the engine air intake from the crankcase. In a vehicle provided with a PCV valve, the device is located in the ventilation passage leading from the crankcase to the engine air intake and the device is downstream of the PCV valve. The device admits outside air to the ventilation passage to lean the gas mixture when the engine creates a vacuum less than 8 psi in the ventilation passage.

  4. Vehicle speed control device

    SciTech Connect

    Thornton-Trump, W.E.

    1987-03-10

    An apparatus is described for automatically limiting the speed of a vehicle powered by an internal combustion engine having a spark ignition system with an ignition coil, comprising: sensor means for generating a speed signal directly representative of the speed of the vehicle comprising a series of speed signal pulses having a pulse repetition frequency proportional to the speed of the vehicle; control means for converting speed signal pulses into a DC voltage proportional to the vehicle speed; means for comparing the DC voltage to a predetermined DC voltage having substantially zero AC components representative of a predetermined maximum speed and for generating a difference signal in response thereto; and means for generating a pulse-width modulated control signal responsive to the difference signal; power means responsive to the control signal for intermittently interrupting the ignition system.

  5. Dual control active superconductive devices

    DOEpatents

    Martens, Jon S.; Beyer, James B.; Nordman, James E.; Hohenwarter, Gert K. G.

    1993-07-20

    A superconducting active device has dual control inputs and is constructed such that the output of the device is effectively a linear mix of the two input signals. The device is formed of a film of superconducting material on a substrate and has two main conduction channels, each of which includes a weak link region. A first control line extends adjacent to the weak link region in the first channel and a second control line extends adjacent to the weak link region in the second channel. The current flowing from the first channel flows through an internal control line which is also adjacent to the weak link region of the second channel. The weak link regions comprise small links of superconductor, separated by voids, through which the current flows in each channel. Current passed through the control lines causes magnetic flux vortices which propagate across the weak link regions and control the resistance of these regions. The output of the device taken across the input to the main channels and the output of the second main channel and the internal control line will constitute essentially a linear mix of the two input signals imposed on the two control lines. The device is especially suited to microwave applications since it has very low input capacitance, and is well suited to being formed of high temperature superconducting materials since all of the structures may be formed coplanar with one another on a substrate.

  6. Control method for prosthetic devices

    NASA Technical Reports Server (NTRS)

    Bozeman, Richard J., Jr. (Inventor)

    1995-01-01

    A control system and method for prosthetic devices is provided. The control system comprises a transducer for receiving movement from a body part for generating a sensing signal associated with that movement. The sensing signal is processed by a linearizer for linearizing the sensing signal to be a linear function of the magnitude of the distance moved by the body part. The linearized sensing signal is normalized to be a function of the entire range of body part movement from the no-shrug position of the moveable body part. The normalized signal is divided into a plurality of discrete command signals. The discrete command signals are used by typical converter devices which are in operational association with the prosthetic device. The converter device uses the discrete command signals for driving the moveable portions of the prosthetic device and its sub-prosthesis. The method for controlling a prosthetic device associated with the present invention comprises the steps of receiving the movement from the body part, generating a sensing signal in association with the movement of the body part, linearizing the sensing signal to be a linear function of the magnitude of the distance moved by the body part, normalizing the linear signal to be a function of the entire range of the body part movement, dividing the normalized signal into a plurality of discrete command signals, and implementing the plurality of discrete command signals for driving the respective moveable prosthesis device and its sub-prosthesis.

  7. CALUTRON CONTROL DEVICE

    DOEpatents

    Baldwin, L.W.

    1959-08-25

    Several interlock and control circuits for a calutron are described. In one of the arrangements, the ton source cooling water flow is interlocked with the current supply to the heaters assoctated with the charge chamber, arc chamber, and electrode structure. When the ion source coolant flow rate exceeds a predetermined level, the heater associated with the charge chamber is energized. After the charge chamber has reached a predetermined temperature, the arc chamber heater is energized. Thereafter, the electrode structure heater is energized and the ion source is ready to have the operating voltages applied.

  8. Pollution Control Device

    NASA Technical Reports Server (NTRS)

    1989-01-01

    BHA Group Inc.'s PrecipTech Power Guard SQ-200 automatic voltage controller, combined with a remote computer, is an automatic management system for smoke-cleaning precipitators. It is the second generation of the SQ 100 developed at Langley Research Center, and was commercialized by two NASA employees. An electrostatic precipitator cleans the smoke by removing particulate matter from smokestack gases before gases are expelled into the atmosphere. Smokestack gas is passed through a precipitator chamber and exposed to an electrostatic field; dust particles in the gas become electrically charged, migrate to collection surfaces and are "captured." Developed under a NASA program seeking a way to dispose refuse, the system monitors sparking, automatically adjusts to changes in operating conditions and does not require a skilled operator.

  9. Control System for Prosthetic Devices

    NASA Technical Reports Server (NTRS)

    Bozeman, Richard J. (Inventor)

    1996-01-01

    A control system and method for prosthetic devices is provided. The control system comprises a transducer for receiving movement from a body part for generating a sensing signal associated with that of movement. The sensing signal is processed by a linearizer for linearizing the sensing signal to be a linear function of the magnitude of the distance moved by the body part. The linearized sensing signal is normalized to be a function of the entire range of body part movement from the no-shrug position of the moveable body part through the full-shrg position of the moveable body part. The normalized signal is divided into a plurality of discrete command signals. The discrete command signals are used by typical converter devices which are in operational association with the prosthetic device. The converter device uses the discrete command signals for driving the moveable portions of the prosthetic device and its sub-prosthesis. The method for controlling a prosthetic device associated with the present invention comprises the steps of receiving the movement from the body part, generating a sensing signal in association with the movement of the body part, linearizing the sensing signal to be a linear function of the magnitude of the distance moved by the body part, normalizing the linear signal to be a function of the entire range of the body part movement, dividing the normalized signal into a plurality of discrete command signals, and implementing the plurality of discrete command signals for driving the respective moveable prosthesis device and its sub-prosthesis.

  10. 40 CFR 63.3555 - How do I determine the outlet THC emissions and add-on control device emission destruction or...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... section. (1) Use Method 1 or 1A of appendix A to 40 CFR part 60, as appropriate, to select sampling sites and velocity traverse points. (2) Use Method 2, 2A, 2C, 2D, 2F, or 2G of appendix A to 40 CFR part 60... CFR part 60, as appropriate, for gas analysis to determine dry molecular weight. You may also use...

  11. 40 CFR 63.3555 - How do I determine the outlet THC emissions and add-on control device emission destruction or...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... section. (1) Use Method 1 or 1A of appendix A to 40 CFR part 60, as appropriate, to select sampling sites and velocity traverse points. (2) Use Method 2, 2A, 2C, 2D, 2F, or 2G of appendix A to 40 CFR part 60... CFR part 60, as appropriate, for gas analysis to determine dry molecular weight. You may also use...

  12. 40 CFR 63.3174 - What are the requirements for a capture system or add-on control device which is not taken into...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Automobiles and Light-Duty Trucks Compliance Requirements for the Combined Primer-Surfacer, Topcoat, Final Repair, Glass Bonding Primer, and Glass Bonding Adhesive Emission Limitations and the Separate Electrodeposition Primer Emission Limitations § 63.3174 What are the requirements for a capture system or...

  13. 40 CFR 63.3174 - What are the requirements for a capture system or add-on control device which is not taken into...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Automobiles and Light-Duty Trucks Compliance Requirements for the Combined Primer-Surfacer, Topcoat, Final Repair, Glass Bonding Primer, and Glass Bonding Adhesive Emission Limitations and the Separate Electrodeposition Primer Emission Limitations § 63.3174 What are the requirements for a capture system or...

  14. 40 CFR 63.4966 - How do I establish the emission capture system and add-on control device operating limits during...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... total regeneration desorbing gas (e.g., steam or nitrogen) mass flow for each regeneration cycle, and the carbon bed temperature after each carbon bed regeneration and cooling cycle, for the regeneration... provisions for the use of an alternative monitoring method as set forth in 40 CFR 63.8(f)....

  15. 40 CFR 63.4767 - How do I establish the emission capture system and add-on control device operating limits during...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... regeneration desorbing gas (e.g., steam or nitrogen) mass flow for each regeneration cycle, and the carbon bed temperature after each carbon bed regeneration and cooling cycle for the regeneration cycle either immediately... are the minimum total desorbing gas mass flow recorded during the regeneration cycle, and the...

  16. 40 CFR 63.3967 - How do I establish the emission capture system and add-on control device operating limits during...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    .... (1) You must monitor and record the total regeneration desorbing gas (e.g., steam or nitrogen) mass flow for each regeneration cycle, and the carbon bed temperature after each carbon bed regeneration and cooling cycle for the regeneration cycle either immediately preceding or immediately following...

  17. 40 CFR 63.3967 - How do I establish the emission capture system and add-on control device operating limits during...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    .... (1) You must monitor and record the total regeneration desorbing gas (e.g., steam or nitrogen) mass flow for each regeneration cycle, and the carbon bed temperature after each carbon bed regeneration and cooling cycle for the regeneration cycle either immediately preceding or immediately following...

  18. 40 CFR 63.3556 - How do I establish the emission capture system and add-on control device operating limits during...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... must monitor and record the total regeneration desorbing gas (e.g., steam or nitrogen) mass flow for each regeneration cycle, and the carbon bed temperature after each carbon bed regeneration and cooling cycle for the regeneration cycle either immediately preceding or immediately following the...

  19. 40 CFR 63.4567 - How do I establish the emission capture system and add-on control device operating limits during...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...., steam or nitrogen) mass flow for each regeneration cycle, and the carbon bed temperature after each carbon bed regeneration and cooling cycle for the regeneration cycle either immediately preceding or... the minimum total desorbing gas mass flow recorded during the regeneration cycle and the...

  20. 40 CFR 63.4167 - How do I establish the emission capture system and add-on control device operating limits during...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... gas (e.g., steam or nitrogen) mass flow for each regeneration cycle and the carbon bed temperature after each carbon bed regeneration and cooling cycle for the regeneration cycle either immediately... are the minimum total desorbing gas mass flow recorded during the regeneration cycle and the...

  1. 40 CFR 63.4567 - How do I establish the emission capture system and add-on control device operating limits during...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...., steam or nitrogen) mass flow for each regeneration cycle, and the carbon bed temperature after each carbon bed regeneration and cooling cycle for the regeneration cycle either immediately preceding or... the minimum total desorbing gas mass flow recorded during the regeneration cycle and the...

  2. 40 CFR 63.3556 - How do I establish the emission capture system and add-on control device operating limits during...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... must monitor and record the total regeneration desorbing gas (e.g., steam or nitrogen) mass flow for each regeneration cycle, and the carbon bed temperature after each carbon bed regeneration and cooling cycle for the regeneration cycle either immediately preceding or immediately following the...

  3. 40 CFR 63.4167 - How do I establish the emission capture system and add-on control device operating limits during...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... nitrogen) mass flow for each regeneration cycle and the carbon bed temperature after each carbon bed regeneration and cooling cycle for the regeneration cycle either immediately preceding or immediately following... desorbing gas mass flow recorded during the regeneration cycle and the maximum carbon bed...

  4. 40 CFR 63.4767 - How do I establish the emission capture system and add-on control device operating limits during...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... and record the total regeneration desorbing gas (e.g., steam or nitrogen) mass flow for each regeneration cycle, and the carbon bed temperature after each carbon bed regeneration and cooling cycle for the regeneration cycle either immediately preceding or immediately following the performance test. (2)...

  5. 40 CFR 63.3546 - How do I establish the emission capture system and add-on control device operating limits during...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... must monitor and record the total regeneration desorbing gas (e.g., steam or nitrogen) mass flow for each regeneration cycle, and the carbon bed temperature after each carbon bed regeneration and cooling cycle for the regeneration cycle either immediately preceding or immediately following the...

  6. 40 CFR 63.3546 - How do I establish the emission capture system and add-on control device operating limits during...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... gas (e.g., steam or nitrogen) mass flow for each regeneration cycle, and the carbon bed temperature after each carbon bed regeneration and cooling cycle for the regeneration cycle either immediately... are the minimum total desorbing gas mass flow recorded during the regeneration cycle, and the...

  7. 40 CFR 63.4966 - How do I establish the emission capture system and add-on control device operating limits during...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... total regeneration desorbing gas (e.g., steam or nitrogen) mass flow for each regeneration cycle, and the carbon bed temperature after each carbon bed regeneration and cooling cycle, for the regeneration... provisions for the use of an alternative monitoring method as set forth in 40 CFR 63.8(f)....

  8. 40 CFR 63.3555 - How do I determine the outlet THC emissions and add-on control device emission destruction or...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... alternative to Method 3B, the manual method for measuring the oxygen, carbon dioxide, and carbon monoxide.... (1) Use Method 1 or 1A of appendix A to 40 CFR part 60, as appropriate, to select sampling sites and velocity traverse points. (2) Use Method 2, 2A, 2C, 2D, 2F, or 2G of appendix A to 40 CFR part 60,...

  9. 40 CFR 63.3555 - How do I determine the outlet THC emissions and add-on control device emission destruction or...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... alternative to Method 3B, the manual method for measuring the oxygen, carbon dioxide, and carbon monoxide.... (1) Use Method 1 or 1A of appendix A to 40 CFR part 60, as appropriate, to select sampling sites and velocity traverse points. (2) Use Method 2, 2A, 2C, 2D, 2F, or 2G of appendix A to 40 CFR part 60,...

  10. 40 CFR 63.3555 - How do I determine the outlet THC emissions and add-on control device emission destruction or...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... an alternative to Method 3B, the manual method for measuring the oxygen, carbon dioxide, and carbon... section. (1) Use Method 1 or 1A of appendix A to 40 CFR part 60, as appropriate, to select sampling sites and velocity traverse points. (2) Use Method 2, 2A, 2C, 2D, 2F, or 2G of appendix A to 40 CFR part...

  11. 40 CFR 63.3169 - What are the requirements for a capture system or add-on control device which is not taken into...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Primer, Primer-Surfacer, Topcoat, Final Repair, Glass Bonding Primer, and Glass Bonding Adhesive Emission... Primer, and Glass Bonding Adhesive Emission Limitations and the Separate Electrodeposition...

  12. 40 CFR 63.3169 - What are the requirements for a capture system or add-on control device which is not taken into...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Electrodeposition Primer, Primer-Surfacer, Topcoat, Final Repair, Glass Bonding Primer, and Glass Bonding Adhesive... Primer, and Glass Bonding Adhesive Emission Limitations and the Separate Electrodeposition...

  13. 40 CFR 63.3169 - What are the requirements for a capture system or add-on control device which is not taken into...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Electrodeposition Primer, Primer-Surfacer, Topcoat, Final Repair, Glass Bonding Primer, and Glass Bonding Adhesive... Primer, and Glass Bonding Adhesive Emission Limitations and the Separate Electrodeposition...

  14. 40 CFR 63.4363 - How do I establish the add-on control device operating limits during the performance test?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... performance test, you must monitor and record the temperature at the inlet to the catalyst bed and the temperature difference across the catalyst bed at least once every 15 minutes during each of the three test... temperature at the inlet to the catalyst bed and the average temperature difference across the catalyst...

  15. 40 CFR 63.9324 - How do I establish the emission capture system and add-on control device operating limits during...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... performance test, you must monitor and record the temperature just before the catalyst bed and the temperature difference across the catalyst bed at least once every 15 minutes during each of the three test runs. (2) Use... before the catalyst bed and the average temperature difference across the catalyst bed maintained...

  16. 40 CFR 63.4363 - How do I establish the add-on control device operating limits during the performance test?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... performance test, you must monitor and record the temperature at the inlet to the catalyst bed and the temperature difference across the catalyst bed at least once every 15 minutes during each of the three test... temperature at the inlet to the catalyst bed and the average temperature difference across the catalyst...

  17. 40 CFR 63.4363 - How do I establish the add-on control device operating limits during the performance test?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... performance test, you must monitor and record the temperature at the inlet to the catalyst bed and the temperature difference across the catalyst bed at least once every 15 minutes during each of the three test... temperature at the inlet to the catalyst bed and the average temperature difference across the catalyst...

  18. 40 CFR 63.4363 - How do I establish the add-on control device operating limits during the performance test?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... performance test, you must monitor and record the temperature at the inlet to the catalyst bed and the temperature difference across the catalyst bed at least once every 15 minutes during each of the three test... temperature at the inlet to the catalyst bed and the average temperature difference across the catalyst...

  19. 40 CFR 63.4363 - How do I establish the add-on control device operating limits during the performance test?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... performance test, you must monitor and record the temperature at the inlet to the catalyst bed and the temperature difference across the catalyst bed at least once every 15 minutes during each of the three test... temperature at the inlet to the catalyst bed and the average temperature difference across the catalyst...

  20. 40 CFR 63.9324 - How do I establish the emission capture system and add-on control device operating limits during...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... performance test, you must monitor and record the temperature just before the catalyst bed and the temperature difference across the catalyst bed at least once every 15 minutes during each of the three test runs. (2) Use... before the catalyst bed and the average temperature difference across the catalyst bed maintained...

  1. 40 CFR 63.9324 - How do I establish the emission capture system and add-on control device operating limits during...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... performance test, you must monitor and record the temperature just before the catalyst bed and the temperature difference across the catalyst bed at least once every 15 minutes during each of the three test runs. (2) Use... before the catalyst bed and the average temperature difference across the catalyst bed maintained...

  2. 40 CFR 63.9324 - How do I establish the emission capture system and add-on control device operating limits during...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... performance test, you must monitor and record the temperature just before the catalyst bed and the temperature difference across the catalyst bed at least once every 15 minutes during each of the three test runs. (2) Use... before the catalyst bed and the average temperature difference across the catalyst bed maintained...

  3. 40 CFR 63.3546 - How do I establish the emission capture system and add-on control device operating limits during...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... the performance test, you must monitor and record the combustion temperature at least once every 15 minutes during each of the three test runs. You must monitor the temperature in the firebox of the thermal...) and (4) of this section. (1) During the performance test, you must monitor and record the...

  4. 40 CFR 63.3556 - How do I establish the emission capture system and add-on control device operating limits during...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... this section. (1) During the performance test, you must monitor and record the combustion temperature at least once every 15 minutes during each of the three test runs. You must monitor the temperature...)(1) and (2) or paragraphs (b)(3) and (4) of this section. (1) During the performance test, you...

  5. 40 CFR 63.9324 - How do I establish the emission capture system and add-on control device operating limits during...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... and record the combustion temperature at least once every 15 minutes during each of the three test... performance test to calculate and record the average combustion temperature maintained during the performance test. This average combustion temperature is the minimum operating limit for your thermal oxidizer....

  6. 40 CFR 63.3169 - What are the requirements for a capture system or add-on control device which is not taken into...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...-Surfacer, Topcoat, Final Repair, Glass Bonding Primer, and Glass Bonding Adhesive Emission Limitations § 63... Primer, and Glass Bonding Adhesive Emission Limitations and the Separate Electrodeposition...

  7. 40 CFR 63.3169 - What are the requirements for a capture system or add-on control device which is not taken into...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...-Surfacer, Topcoat, Final Repair, Glass Bonding Primer, and Glass Bonding Adhesive Emission Limitations § 63... Primer, and Glass Bonding Adhesive Emission Limitations and the Separate Electrodeposition...

  8. 40 CFR 63.3167 - How do I establish the add-on control device operating limits during the performance test?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 CFR 60.395(c), then you may set the minimum operating limit for the combustion temperature for... oxidizers in 40 CFR 60.395(c), then you may set the minimum operating limit for the combustion temperature... catalytic oxidizers in 40 CFR 60.395(c), then you may set the minimum operating limits for each...

  9. 40 CFR 63.3167 - How do I establish the add-on control device operating limits during the performance test?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 CFR 60.395(c), then you may set the minimum operating limit for the combustion temperature for... oxidizers in 40 CFR 60.395(c), then you may set the minimum operating limit for the combustion temperature... catalytic oxidizers in 40 CFR 60.395(c), then you may set the minimum operating limits for each...

  10. 40 CFR 63.3167 - How do I establish the add-on control device operating limits during the performance test?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 CFR 60.395(c), then you may set the minimum operating limit for the combustion temperature for... oxidizers in 40 CFR 60.395(c), then you may set the minimum operating limit for the combustion temperature... catalytic oxidizers in 40 CFR 60.395(c), then you may set the minimum operating limits for each...

  11. 40 CFR 63.3167 - How do I establish the add-on control device operating limits during the performance test?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 CFR 60.395(c), then you may set the minimum operating limit for the combustion temperature for... oxidizers in 40 CFR 60.395(c), then you may set the minimum operating limit for the combustion temperature... catalytic oxidizers in 40 CFR 60.395(c), then you may set the minimum operating limits for each...

  12. 40 CFR 63.3167 - How do I establish the add-on control device operating limits during the performance test?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 CFR 60.395(c), then you may set the minimum operating limit for the combustion temperature for... oxidizers in 40 CFR 60.395(c), then you may set the minimum operating limit for the combustion temperature... catalytic oxidizers in 40 CFR 60.395(c), then you may set the minimum operating limits for each...

  13. Compact, Controlled Resistance Exercise Device

    NASA Technical Reports Server (NTRS)

    Paulus, David C.; DeWitt, John K.; Reich, Alton J.; Shaw, James E.; Deaconu, Stelu S.

    2011-01-01

    Spaceflight leads to muscle and bone atrophy. Isoinertial (free-weight) exercises provide a sufficient stimulus to elicit increases in both muscle strength and bone mineral density in Earth-based studies. While exercise equipment is in use on the International Space Station for crewmember health maintenance, current devices are too large to place in a transport vehicle or small spacecraft. Therefore, a portable computer controlled resistance exercise device is being developed that is able to simulate the inertial loading experienced when lifting a mass on Earth. This portable device weighs less than 50 lb and can simulate the resistance of lifting and lowering up to 600 lb of free-weights. The objective is to allow crewmembers to perform resistance exercise with loads capable of maintaining muscle and bone health. The device is reconfigurable and allows for the performance of typical Earth-based free-weight exercises. Forces exerted, volume of work, range of motion, time-under-tension, and speed/ acceleration of movement are recorded and can be remotely monitored to track progress and modify individual protocols based on exercise session data. A performance evaluation will be completed and data will be presented that include ground-reaction force comparisons between the device and free-weight dead-lifts over a spectrum of resistance levels. Movement biomechanics will also be presented.

  14. Add-on prolonged-release melatonin for cognitive function and sleep in mild to moderate Alzheimer’s disease: a 6-month, randomized, placebo-controlled, multicenter trial

    PubMed Central

    Wade, Alan G; Farmer, Mildred; Harari, Gil; Fund, Naama; Laudon, Moshe; Nir, Tali; Frydman-Marom, Anat; Zisapel, Nava

    2014-01-01

    Purpose A link between poor sleep quality and Alzheimer’s disease (AD) has recently been suggested. Since endogenous melatonin levels are already reduced at preclinical AD stages, it is important to ask whether replenishing the missing hormone would be beneficial in AD and whether any such effects would be related to the presence of sleep disorder in patients. Patients and methods The effects of add-on prolonged-release melatonin (PRM) (2 mg) to standard therapy on cognitive functioning and sleep were investigated in 80 patients (men [50.7%], women [49.3%], average age 75.3 years [range, 52–85 years]) diagnosed with mild to moderate AD, with and without insomnia comorbidity, and receiving standard therapy (acetylcholinesterase inhibitors with or without memantine). In this randomized, double-blind, parallel-group study, patients were treated for 2 weeks with placebo and then randomized (1:1) to receive 2 mg of PRM or placebo nightly for 24 weeks, followed by 2 weeks placebo. The AD Assessment Scale–Cognition (ADAS-Cog), Instrumental Activities of Daily Living (IADL), Mini–Mental State Examination (MMSE), sleep, as assessed by the Pittsburgh Sleep Quality Index (PSQI) and a daily sleep diary, and safety parameters were measured. Results Patients treated with PRM (24 weeks) had significantly better cognitive performance than those treated with placebo, as measured by the IADL (P=0.004) and MMSE (P=0.044). Mean ADAS-Cog did not differ between the groups. Sleep efficiency, as measured by the PSQI, component 4, was also better with PRM (P=0.017). In the comorbid insomnia (PSQI ≥6) subgroup, PRM treatment resulted in significant and clinically meaningful effects versus the placebo, in mean IADL (P=0.032), MMSE score (+1.5 versus −3 points) (P=0.0177), and sleep efficiency (P=0.04). Median ADAS-Cog values (−3.5 versus +3 points) (P=0.045) were significantly better with PRM. Differences were more significant at longer treatment duration. PRM was well

  15. Portable control device for networked mobile robots

    DOEpatents

    Feddema, John T.; Byrne, Raymond H.; Bryan, Jon R.; Harrington, John J.; Gladwell, T. Scott

    2002-01-01

    A handheld control device provides a way for controlling one or multiple mobile robotic vehicles by incorporating a handheld computer with a radio board. The device and software use a personal data organizer as the handheld computer with an additional microprocessor and communication device on a radio board for use in controlling one robot or multiple networked robots.

  16. Efficacy and Safety of Alirocumab as Add-on Therapy in High–Cardiovascular-Risk Patients With Hypercholesterolemia Not Adequately Controlled With Atorvastatin (20 or 40 mg) or Rosuvastatin (10 or 20 mg): Design and Rationale of the ODYSSEY OPTIONS Studies

    PubMed Central

    Robinson, Jennifer G; Colhoun, Helen M; Bays, Harold E; Jones, Peter H; Du, Yunling; Hanotin, Corinne; Donahue, Stephen

    2014-01-01

    The phase 3 ODYSSEY OPTIONS studies (OPTIONS I, NCT01730040; OPTIONS II, NCT01730053) are multicenter, multinational, randomized, double-blind, active-comparator, 24-week studies evaluating the efficacy and safety of alirocumab, a fully human monoclonal antibody targeting proprotein convertase subtilisin/kexin type 9, as add-on therapy in ∼ 650 high-cardiovascular (CV)-risk patients whose low-density lipoprotein cholesterol (LDL-C) levels are ≥100 mg/dL or ≥70 mg/dL according to the CV-risk category, high and very high CV risk, respectively, with atorvastatin (20–40 mg/d) or rosuvastatin (10–20 mg/d). Patients are randomized to receive alirocumab 75 mg via a single, subcutaneous, 1-mL injection by prefilled pen every 2 weeks (Q2W) as add-on therapy to atorvastatin (20–40 mg) or rosuvastatin (10–20 mg); or to receive ezetimibe 10 mg/d as add-on therapy to statin; or to receive statin up-titration; or to switch from atorvastatin to rosuvastatin (OPTIONS I only). At week 12, based on week 8 LDL-C levels, the alirocumab dose may be increased from 75 mg to 150 mg Q2W if LDL-C levels remain ≥100 mg/dL or ≥70 mg/dL in patients with high or very high CV risk, respectively. The primary efficacy endpoint in both studies is difference in percent change in calculated LDL-C from baseline to week 24 in the alirocumab vs control arms. The studies may provide guidance to inform clinical decision-making when patients with CV risk require additional lipid-lowering therapy to further reduce LDL-C levels. The flexibility of the alirocumab dosing regimen allows for individualized therapy based on the degree of LDL-C reduction required to achieve the desired LDL-C level. PMID:25269777

  17. 25 CFR 226.36 - Control devices.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true Control devices. 226.36 Section 226.36 Indians BUREAU OF... AND GAS MINING Requirements of Lessees § 226.36 Control devices. In drilling operations in fields... operations to maintain proper control of subsurface strata....

  18. 25 CFR 226.36 - Control devices.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false Control devices. 226.36 Section 226.36 Indians BUREAU OF... AND GAS MINING Requirements of Lessees § 226.36 Control devices. In drilling operations in fields... operations to maintain proper control of subsurface strata....

  19. 25 CFR 226.36 - Control devices.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false Control devices. 226.36 Section 226.36 Indians BUREAU OF... AND GAS MINING Requirements of Lessees § 226.36 Control devices. In drilling operations in fields... operations to maintain proper control of subsurface strata....

  20. 25 CFR 226.36 - Control devices.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Control devices. 226.36 Section 226.36 Indians BUREAU OF... AND GAS MINING Requirements of Lessees § 226.36 Control devices. In drilling operations in fields... operations to maintain proper control of subsurface strata....

  1. Magnetic field control. [electromechanical torquing device

    NASA Technical Reports Server (NTRS)

    Haeussermann, W. (Inventor)

    1982-01-01

    A torque control for an electromechanical torquing device of a type where a variable clearance occurs between a rotor and field is described. A Hall effect device senses the field present, which would vary as a function of spacing between field and rotor. The output of the Hall effect device controls the power applied to the field so as to provide a well defined field and thus a controlled torque to the rotor which is well defined.

  2. Cursor Control Device Test Battery

    NASA Technical Reports Server (NTRS)

    Holden, Kritina; Sandor, Aniko; Pace, John; Thompson, Shelby

    2013-01-01

    The test battery was developed to provide a standard procedure for cursor control device evaluation. The software was built in Visual Basic and consists of nine tasks and a main menu that integrates the set-up of the tasks. The tasks can be used individually, or in a series defined in the main menu. Task 1, the Unidirectional Pointing Task, tests the speed and accuracy of clicking on targets. Two rectangles with an adjustable width and adjustable center- to-center distance are presented. The task is to click back and forth between the two rectangles. Clicks outside of the rectangles are recorded as errors. Task 2, Multidirectional Pointing Task, measures speed and accuracy of clicking on targets approached from different angles. Twenty-five numbered squares of adjustable width are arranged around an adjustable diameter circle. The task is to point and click on the numbered squares (placed on opposite sides of the circle) in consecutive order. Clicks outside of the squares are recorded as errors. Task 3, Unidirectional (horizontal) Dragging Task, is similar to dragging a file into a folder on a computer desktop. Task 3 requires dragging a square of adjustable width from one rectangle and dropping it into another. The width of each rectangle is adjustable, as well as the distance between the two rectangles. Dropping the square outside of the rectangles is recorded as an error. Task 4, Unidirectional Path Following, is similar to Task 3. The task is to drag a square through a tunnel consisting of two lines. The size of the square and the width of the tunnel are adjustable. If the square touches any of the lines, it is counted as an error and the task is restarted. Task 5, Text Selection, involves clicking on a Start button, and then moving directly to the underlined portion of the displayed text and highlighting it. The pointing distance to the text is adjustable, as well as the to-be-selected font size and the underlined character length. If the selection does not

  3. Daylight control system device and method

    DOEpatents

    Paton, John Douglas

    2009-12-01

    A system and device for and a method of programming and controlling light fixtures is disclosed. A system in accordance with the present invention includes a stationary controller unit that is electrically coupled to the light fixtures. The stationary controller unit is configured to be remotely programmed with a portable commissioning device to automatically control the lights fixtures. The stationary controller unit and the portable commissioning device include light sensors, micro-computers and transceivers for measuring light levels, running programs, storing data and transmitting data between the stationary controller unit and the portable commissioning device. In operation, target light levels selected with the portable commissioning device and the controller unit is remotely programmed to automatically maintain the target level.

  4. Daylight control system, device and method

    DOEpatents

    Paton, John Douglas

    2012-08-28

    A system and device for and a method of programming and controlling light fixtures is disclosed. A system in accordance with the present invention includes a stationary controller unit that is electrically coupled to the light fixtures. The stationary controller unit is configured to be remotely programmed with a portable commissioning device to automatically control the lights fixtures. The stationary controller unit and the portable commissioning device include light sensors, micro-computers and transceivers for measuring light levels, running programs, storing data and transmitting data between the stationary controller unit and the portable commissioning device. In operation, target light levels selected with the portable commissioning device and the controller unit is remotely programmed to automatically maintain the target level.

  5. Daylight control system device and method

    DOEpatents

    Paton, John Douglas

    2007-03-13

    A system and device for and a method of programming and controlling light fixtures is disclosed. A system in accordance with the present invention includes a stationary controller unit that is electrically coupled to the light fixtures. The stationary controller unit is configured to be remotely programmed with a portable commissioning device to automatically control the lights fixtures. The stationary controller unit and the portable commissioning device include light sensors, micro-computers and transceivers for measuring light levels, running programs, storing data and transmitting data between the stationary controller unit and the portable commissioning device. In operation, target light levels selected with the portable commissioning device and the controller unit is remotely programmed to automatically maintain the target level.

  6. DEVICE FOR CONTROL OF OXYGEN PARTIAL PRESSURE

    DOEpatents

    Bradner, H.; Gordon, H.S.

    1957-12-24

    A device is described that can sense changes in oxygen partial pressure and cause a corresponding mechanical displacement sufficient to actuate meters, valves and similar devices. A piston and cylinder arrangement contains a charge of crystalline metal chelate pellets which have the peculiar property of responding to variations in the oxygen content of the ambient atmosphere by undergoing a change in dimension. A lever system amplifies the relative displacement of the piston in the cylinder, and actuates the controlled valving device. This partial pressure oxygen sensing device is useful in controlled chemical reactions or in respiratory devices such as the oxygen demand meters for high altitude aircraft.

  7. System for remote control of underground device

    DOEpatents

    Brumleve, T.D.; Hicks, M.G.; Jones, M.O.

    1975-10-21

    A system is described for remote control of an underground device, particularly a nuclear explosive. The system includes means at the surface of the ground for transmitting a seismic signal sequence through the earth having controlled and predetermined signal characteristics for initiating a selected action in the device. Additional apparatus, located with or adjacent to the underground device, produces electrical signals in response to the seismic signals received and compares these electrical signals with the predetermined signal characteristics.

  8. Linagliptin as add-on therapy to insulin for patients with type 2 diabetes

    PubMed Central

    von Websky, Karoline; Reichetzeder, Christoph; Hocher, Berthold

    2013-01-01

    Type 2 diabetes mellitus (T2DM) is a highly prevalent, progressive disease that often is poorly controlled. The combination of an incretin-based therapy and insulin is a promising approach to optimize the management of glycemic control without hypoglycemia and weight gain. Linagliptin, a recently approved oral dipeptidyl peptidase-4 inhibitor, has a unique pharmacological profile. The convenient, once-daily dosing does not need adjustment in patients with hepatic and/or renal impairment. In clinical studies linagliptin shows an important reduction of blood glucose with an overall safety profile similar to that of placebo. So far, the combination of linagliptin and insulin has been tested in three major clinical studies in different populations. It has been shown that linagliptin is an effective and safe add-on therapy to insulin in patients with T2DM. The efficacy and safety of this combination was also shown in vulnerable, elderly T2DM patients and in patients with T2DM and renal impairment. Favorable effects regarding the counteraction of hypoglycemia make linagliptin especially interesting as an add-on therapy to insulin. This review aims to present the existing clinical studies on the efficacy and safety of linagliptin as add-on therapy to insulin in patients with T2DM in the context of current literature. Additionally, the possible advantages of linagliptin as an add-on therapy to insulin in relation to cardiovascular safety, patient-centered therapy and the prevention of hypoglycemia, are discussed. PMID:24204157

  9. Control method for physical systems and devices

    DOEpatents

    Guckenheimer, John

    1997-01-01

    A control method for stabilizing systems or devices that are outside the control domain of a linear controller is provided. When applied to nonlinear systems, the effectiveness of this method depends upon the size of the domain of stability that is produced for the stabilized equilibrium. If this domain is small compared to the accuracy of measurements or the size of disturbances within the system, then the linear controller is likely to fail within a short period. Failure of the system or device can be catastrophic: the system or device can wander far from the desired equilibrium. The method of the invention presents a general procedure to recapture the stability of a linear controller, when the trajectory of a system or device leaves its region of stability. By using a hybrid strategy based upon discrete switching events within the state space of the system or device, the system or device will return from a much larger domain to the region of stability utilized by the linear controller. The control procedure is robust and remains effective under large classes of perturbations of a given underlying system or device.

  10. Fast-acting nuclear reactor control device

    DOEpatents

    Kotlyar, Oleg M.; West, Phillip B.

    1993-01-01

    A fast-acting nuclear reactor control device for moving and positioning a fety control rod to desired positions within the core of the reactor between a run position in which the safety control rod is outside the reactor core, and a shutdown position in which the rod is fully inserted in the reactor core. The device employs a hydraulic pump/motor, an electric gear motor, and solenoid valve to drive the safety control rod into the reactor core through the entire stroke of the safety control rod. An overrunning clutch allows the safety control rod to freely travel toward a safe position in the event of a partial drive system failure.

  11. Stereovision Imaging in Smart Mobile Phone Using Add on Prisms

    NASA Astrophysics Data System (ADS)

    Bar-Magen Numhauser, Jonathan; Zalevsky, Zeev

    2014-03-01

    In this work we present the use of a prism-based add on component installed on top of a smart phone to achieve stereovision capabilities using iPhone mobile operating system. Through these components and the combination of the appropriate application programming interface and mathematical algorithms the obtained results will permit the analysis of possible enhancements for new uses to such system, in a variety of areas including medicine and communications.

  12. Temperature-controlled fluidic device A concept

    NASA Technical Reports Server (NTRS)

    Rehsteiner, F. H.

    1970-01-01

    Symmetrical fluidic device directly converts electrical signals to mechanical signals in the form of a fluid-flow parameter. This device eliminates or reduces effects of all undesirable parameters on the departure angle, leaving it a function of the controlled wall and jet temperatures.

  13. Electromechanical control of flat optical devices

    NASA Astrophysics Data System (ADS)

    Roy, Tapashree; Zhang, Shuyan; Jung, Il Woong; Capasso, Federico; Lopez, Daniel

    In the recent times flat optical elements, like lenses and beam deflectors, have come to the forefront of scientific research. These devices, also referred to as ``metasurfaces'', use metal or dielectric resonators, arbitrarily spaced with subwavelength resolution on a two dimensional plane, to mimic the phase profile of any conventional bulk optical device and beyond. Such metasurface-based planar devices are compact and lightweight compared to their conventional bulky counterparts. However, most of these nanostructured devices have so far been passive. In this work we introduce an important concept of actively controlling these flat optical devices. A prototype: an electromechanically controlled plasmonic flat lens focusing mid infrared signal in reflection will be presented. The lens is fabricated on a 2.8 micron thin membrane following photolithography processes and integrated with a micro electromechanical system (MEMS) device. When electrostatically actuated, the MEMS platform controls the mechanical tilt angle of the lens along two orthogonal axes by about 16 degrees that in turn controls the scanning of the focal spot. Such actively controlled miniaturized optical devices promise to provide faster, more efficient and often enhanced functionalities.

  14. Robotics and teleoperator-controlled devices.

    PubMed

    Meieran, H B

    1988-08-01

    This paper presents a rationale for and a summary of tasks and missions to which mobile and stationary robots and other teleoperator-controlled devices could be assigned in response to the accidental release of radioactive and other hazardous/toxic materials to the environment. Many of these vehicles and devices currently support operation and maintenance of nuclear power plants and other nuclear industry facilities. This paper also discusses specific missions for these devices at the Three Mile Island and Chernobyl nuclear power plant sites at the time of the accidents. Also discussed is the status of devices under development for future applications, as well as research on robotics. PMID:3410688

  15. Patient's breath controls comfort devices

    NASA Technical Reports Server (NTRS)

    Schrader, M.; Carpenter, B.; Nichols, C. D.

    1972-01-01

    Patient assist system for totally disabled persons was developed which permits a person, so paralyzed as to be unable to move, to activate by breathing, a call system to summon assistance, turn the page of a book, ajust his bed, or do any one of a number of other things. System consists of patient assist control and breath actuated switch.

  16. Vortex control for rotor blade devices

    NASA Technical Reports Server (NTRS)

    Greenblatt, David (Inventor)

    2008-01-01

    To control vortices originating at the tips of a rotor's blades rotating through the air at a revolution frequency f, separation control device(s) are actuated to periodically introduce perturbations into the airflow moving over the blades. The periodic introduction of perturbations is controlled in accordance with a periodic modulating frequency of introduction f.sub.0 while the frequency of the perturbations so-introduced is designated as f.sub.e. Vortex control is achieved when the periodic modulating frequency of introduction f.sub.0 satisfies the relationship nf.ltoreq.f.sub.0.ltoreq.f.sub.e where n is the number of blades.

  17. Handbook on Numerically Controlled Operational Devices.

    ERIC Educational Resources Information Center

    Campbell, Clifton P.

    This handbook presents an organized set of descriptive information on numerically controlled operational devices. The information is intended for those involved in industry and technical education and to contribute to the knowledge of numerical control technology. It is also intended for supervisors, manufacturers, machine operators, and others…

  18. 40 CFR 63.995 - Other control devices.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 10 2011-07-01 2011-07-01 false Other control devices. 63.995 Section... Emission Standards for Closed Vent Systems, Control Devices, Recovery Devices and Routing to a Fuel Gas System or a Process § 63.995 Other control devices. (a) Other control device equipment and...

  19. 40 CFR 63.995 - Other control devices.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 10 2010-07-01 2010-07-01 false Other control devices. 63.995 Section... Emission Standards for Closed Vent Systems, Control Devices, Recovery Devices and Routing to a Fuel Gas System or a Process § 63.995 Other control devices. (a) Other control device equipment and...

  20. Rituximab add-on therapy for breakthrough relapsing multiple sclerosis

    PubMed Central

    Naismith, R.T.; Piccio, L.; Lyons, J.A.; Lauber, J.; Tutlam, N.T.; Parks, B.J.; Trinkaus, K.; Song, S.K.; Cross, A.H.

    2010-01-01

    Objective: B cells and the humoral immune system have been implicated in the pathogenesis of multiple sclerosis (MS). This study sought to evaluate the efficacy, safety, and tolerability of add-on therapy with rituximab, a monoclonal antibody that depletes circulating B cells, in subjects with relapsing MS with breakthrough disease defined by clinical and MRI activity (Class III evidence). Methods: Thirty subjects with a relapse within the past 18 months despite use of an injectable disease-modifying agent, and with at least 1 gadolinium-enhancing (GdE) lesion on any of 3 pretreatment MRIs, received rituximab administered at 375 mg/m2 weekly × 4 doses. Three monthly posttreatment brain MRI scans were obtained beginning 12 weeks after the first infusion. Multiple Sclerosis Functional Composite (MSFC) and Expanded Disability Status Scale (EDSS) were obtained at baseline and throughout the posttreatment follow-up. Results: GdE lesions were reduced after treatment with rituximab, with 74% of posttreatment MRI scans being free of GdE activity compared with 26% free of GdE activity at baseline (p < 0.0001). Median GdE lesions were reduced from 1.0 to 0, and mean number was reduced from 2.81 per month to 0.33 after treatment (88% reduction). MSFC improved as well (p = 0.02). EDSS remained stable. Conclusion: Rituximab add-on therapy was effective based upon blinded radiologic endpoints in this phase II study. In combination with standard injectable therapies, rituximab was well-tolerated with no serious adverse events. B-cell–modulating therapy remains a potential option for treatment of patients with relapsing MS with an inadequate response to standard injectable therapies. Classification of evidence: This study provides Class III evidence that add-on rituximab reduces gadolinium-enhancing brain lesions in multiple sclerosis. GLOSSARY DMT = disease-modifying therapy; EDSS = Expanded Disability Status Scale; FOV = field of view; GdE = gadolinium-enhancing; HACA = human

  1. Piezo Voltage Controlled Planar Hall Effect Devices

    NASA Astrophysics Data System (ADS)

    Zhang, Bao; Meng, Kang-Kang; Yang, Mei-Yin; Edmonds, K. W.; Zhang, Hao; Cai, Kai-Ming; Sheng, Yu; Zhang, Nan; Ji, Yang; Zhao, Jian-Hua; Zheng, Hou-Zhi; Wang, Kai-You

    2016-06-01

    The electrical control of the magnetization switching in ferromagnets is highly desired for future spintronic applications. Here we report on hybrid piezoelectric (PZT)/ferromagnetic (Co2FeAl) devices in which the planar Hall voltage in the ferromagnetic layer is tuned solely by piezo voltages. The change of planar Hall voltage is associated with magnetization switching through 90° in the plane under piezo voltages. Room temperature magnetic NOT and NOR gates are demonstrated based on the piezo voltage controlled Co2FeAl planar Hall effect devices without the external magnetic field. Our demonstration may lead to the realization of both information storage and processing using ferromagnetic materials.

  2. Contactless heat flux control with photonic devices

    SciTech Connect

    Ben-Abdallah, Philippe; Biehs, Svend-Age

    2015-05-15

    The ability to control electric currents in solids using diodes and transistors is undoubtedly at the origin of the main developments in modern electronics which have revolutionized the daily life in the second half of 20th century. Surprisingly, until the year 2000 no thermal counterpart for such a control had been proposed. Since then, based on pioneering works on the control of phononic heat currents new devices were proposed which allow for the control of heat fluxes carried by photons rather than phonons or electrons. The goal of the present paper is to summarize the main advances achieved recently in the field of thermal energy control with photons.

  3. A subsurface add-on for standard atomic force microscopes

    SciTech Connect

    Verbiest, G. J.; Zalm, D. J. van der; Oosterkamp, T. H.; Rost, M. J.

    2015-03-15

    The application of ultrasound in an Atomic Force Microscope (AFM) gives access to subsurface information. However, no commercially AFM exists that is equipped with this technique. The main problems are the electronic crosstalk in the AFM setup and the insufficiently strong excitation of the cantilever at ultrasonic (MHz) frequencies. In this paper, we describe the development of an add-on that provides a solution to these problems by using a special piezo element with a lowest resonance frequency of 2.5 MHz and by separating the electronic connection for this high frequency piezo element from all other connections. In this sense, we support researches with the possibility to perform subsurface measurements with their existing AFMs and hopefully pave also the way for the development of a commercial AFM that is capable of imaging subsurface features with nanometer resolution.

  4. System and method for controlling remote devices

    DOEpatents

    Carrender, Curtis Lee; Gilbert, Ronald W.; Scott, Jeff W.; Clark, David A.

    2006-02-07

    A system and method for controlling remote devices utilizing a radio frequency identification (RFID) tag device having a control circuit adapted to render the tag device, and associated objects, permanently inoperable in response to radio-frequency control signals. The control circuit is configured to receive the control signals that can include an enable signal, and in response thereto enable an associated object, such as a weapon; and in response to a disable signal, to disable the tag itself, or, if desired, to disable the associated weapon or both the device and the weapon. Permanent disabling of the tag can be accomplished by several methods, including, but not limited to, fusing a fusable link, breaking an electrically conductive path, permanently altering the modulation or backscattering characteristics of the antenna circuit, and permanently erasing an associated memory. In this manner, tags in the possession of unauthorized employees can be remotely disabled, and weapons lost on a battlefield can be easily tracked and enabled or disabled automatically or at will.

  5. Evaluation of Motor Control Using Haptic Device

    NASA Astrophysics Data System (ADS)

    Nuruki, Atsuo; Kawabata, Takuro; Shimozono, Tomoyuki; Yamada, Masafumi; Yunokuchi, Kazutomo

    When the kinesthesia and the touch act at the same time, such perception is called haptic perception. This sense has the key role in motor information on the force and position control. The haptic perception is important in the field where the evaluation of the motor control is needed. The purpose of this paper is to evaluate the motor control, perception of heaviness and distance in normal and fatigue conditions using psychophysical experiment. We used a haptic device in order to generate precise force and distance, but the precedent of the evaluation system with the haptic device has been few. Therefore, it is another purpose to examine whether the haptic device is useful as evaluation system for the motor control. The psychophysical quantity of force and distance was measured by two kinds of experiments. Eight healthy subjects participated in this study. The stimulation was presented by haptic device [PHANTOM Omni: SensAble Company]. The subjects compared between standard and test stimulation, and answered it had felt which stimulation was strong. In the result of the psychophysical quantity of force, just noticeable difference (JND) had a significant difference, and point of subjective equality (PSE) was not different between normal and muscle fatigue. On the other hand, in the result of the psychophysical quantity of distance, JND and PSE were not difference between normal and muscle fatigue. These results show that control of force was influenced, but control of distance was not influenced in muscle fatigue. Moreover, these results suggested that the haptic device is useful as the evaluation system for the motor control.

  6. Study protocol of Prednisone in episodic Cluster Headache (PredCH): a randomized, double-blind, placebo-controlled parallel group trial to evaluate the efficacy and safety of oral prednisone as an add-on therapy in the prophylactic treatment of episodic cluster headache with verapamil

    PubMed Central

    2013-01-01

    Background Episodic cluster headache (ECH) is a primary headache disorder that severely impairs patient’s quality of life. First-line therapy in the initiation of a prophylactic treatment is verapamil. Due to its delayed onset of efficacy and the necessary slow titration of dosage for tolerability reasons prednisone is frequently added by clinicians to the initial prophylactic treatment of a cluster episode. This treatment strategy is thought to effectively reduce the number and intensity of cluster attacks in the beginning of a cluster episode (before verapamil is effective). This study will assess the efficacy and safety of oral prednisone as an add-on therapy to verapamil and compare it to a monotherapy with verapamil in the initial prophylactic treatment of a cluster episode. Methods and design PredCH is a prospective, randomized, double-blind, placebo-controlled trial with parallel study arms. Eligible patients with episodic cluster headache will be randomized to a treatment intervention with prednisone or a placebo arm. The multi-center trial will be conducted in eight German headache clinics that specialize in the treatment of ECH. Discussion PredCH is designed to assess whether oral prednisone added to first-line agent verapamil helps reduce the number and intensity of cluster attacks in the beginning of a cluster episode as compared to monotherapy with verapamil. Trial registration German Clinical Trials Register DRKS00004716 PMID:23889923

  7. Control system and method for prosthetic devices

    NASA Technical Reports Server (NTRS)

    Bozeman, Richard J., Jr. (Inventor)

    1992-01-01

    A control system and method for prosthetic devices is provided. The control system comprises a transducer for receiving movement from a body part for generating a sensing signal associated with that movement. The sensing signal is processed by a linearizer for linearizing the sensing signal to be a linear function of the magnitude of the distance moved by the body part. The linearized sensing signal is normalized to be a function of the entire range of body part movement from the no-shrug position of the movable body part through the full-shrug position of the movable body part. The normalized signal is divided into a plurality of discrete command signals. The discrete command signals are used by typical converter devices which are in operational association with the prosthetic device. The converter device uses the discrete command signals for driving the movable portions of the prosthetic device and its sub-prosthesis. The method for controlling a prosthetic device associated with the present invention comprises the steps of receiving the movement from the body part, generating a sensing signal in association with the movement of the body part, linearizing the sensing signal to be a linear function of the magnitude of the distance moved by the body part, normalizing the linear signal to be a function of the entire range of the body part movement, dividing the normalized signal into a plurality of discrete command signals, and implementing the plurality of discrete command signals for driving the respective movable prosthesis device and its sub-prosthesis.

  8. 14 CFR 23.373 - Speed control devices.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Speed control devices. 23.373 Section 23....373 Speed control devices. If speed control devices (such as spoilers and drag flaps) are incorporated....441 and 23.443, with the device extended at speeds up to the placard device extended speed; and (b)...

  9. 14 CFR 23.373 - Speed control devices.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Speed control devices. 23.373 Section 23....373 Speed control devices. If speed control devices (such as spoilers and drag flaps) are incorporated....441 and 23.443, with the device extended at speeds up to the placard device extended speed; and (b)...

  10. 14 CFR 23.373 - Speed control devices.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Speed control devices. 23.373 Section 23....373 Speed control devices. If speed control devices (such as spoilers and drag flaps) are incorporated....441 and 23.443, with the device extended at speeds up to the placard device extended speed; and (b)...

  11. 14 CFR 23.373 - Speed control devices.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Speed control devices. 23.373 Section 23....373 Speed control devices. If speed control devices (such as spoilers and drag flaps) are incorporated....441 and 23.443, with the device extended at speeds up to the placard device extended speed; and (b)...

  12. 14 CFR 23.373 - Speed control devices.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Speed control devices. 23.373 Section 23....373 Speed control devices. If speed control devices (such as spoilers and drag flaps) are incorporated....441 and 23.443, with the device extended at speeds up to the placard device extended speed; and (b)...

  13. EVALUATIONS OF NOVEL PARTICULATE CONTROL DEVICES

    EPA Science Inventory

    The report gives results of fractional and overall mass efficiency tests of four novel particulate control devices. Three were wet scrubbers: an Aronetics (Chemico) Two-Phase Jet Scrubber, an Entoleter Centrifield Scrubber, and a CEA Variable-Throat Venturi Scrubber. The fourth w...

  14. Boundary layer control device for duct silencers

    NASA Technical Reports Server (NTRS)

    Schmitz, Fredric H. (Inventor); Soderman, Paul T. (Inventor)

    1993-01-01

    A boundary layer control device includes a porous cover plate, an acoustic absorber disposed under the porous cover plate, and a porous flow resistive membrane interposed between the porous cover plate and the acoustic absorber. The porous flow resistive membrane has a flow resistance low enough to permit sound to enter the acoustic absorber and high enough to damp unsteady flow oscillations.

  15. Fluid control structures in microfluidic devices

    NASA Technical Reports Server (NTRS)

    Mathies, Richard A. (Inventor); Grover, William H. (Inventor); Skelley, Alison (Inventor); Lagally, Eric (Inventor); Liu, Chung N. (Inventor)

    2008-01-01

    Methods and apparatus for implementing microfluidic analysis devices are provided. A monolithic elastomer membrane associated with an integrated pneumatic manifold allows the placement and actuation of a variety of fluid control structures, such as structures for pumping, isolating, mixing, routing, merging, splitting, preparing, and storing volumes of fluid. The fluid control structures can be used to implement a variety of sample introduction, preparation, processing, and storage techniques.

  16. Fluid control structures in microfluidic devices

    DOEpatents

    Mathies, Richard A.; Grover, William H.; Skelley, Alison; Lagally, Eric; Liu, Chung N.

    2008-11-04

    Methods and apparatus for implementing microfluidic analysis devices are provided. A monolithic elastomer membrane associated with an integrated pneumatic manifold allows the placement and actuation of a variety of fluid control structures, such as structures for pumping, isolating, mixing, routing, merging, splitting, preparing, and storing volumes of fluid. The fluid control structures can be used to implement a variety of sample introduction, preparation, processing, and storage techniques.

  17. 30 CFR 75.330 - Face ventilation control devices.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Face ventilation control devices. 75.330... control devices. (a) Brattice cloth, ventilation tubing and other face ventilation control devices shall be made of flame-resistant material approved by MSHA. (b)(1) Ventilation control devices shall...

  18. Hydraulic control device for automatic transmissions

    SciTech Connect

    Sakaguchi, Y.; Taga, Y.; Kashihara, Y.

    1989-06-20

    This patent describes a hydraulic control device for an automatic transmission including a control unit, a shift gear mechanism, clutches and brakes for controlling the shift gear mechanism, hydraulic servos for actuating the clutches and brakes to control the shift gear mechanism and having hydraulic servo for a forward clutch, and an electronically operated regulating value for regulating pressure according to signals from the control unit. The control device consists of: a selecting value switched by signals indicating stopping and running condition of a vehicle, the selecting valve being connected to the hydraulic servo for the forward clutch for engaging and transmitting torque during the forward running conditon, the selecting valve selectively receiving a line pressure and a control pressure from the regulating valve so that hydraulic pressure just below engaging pressure regulated by the regulating valve is applied to the hydraulic servo for the forward clutch during stopping, and a line pressure is applied to the hydraulic servo for the forward clutch during running.

  19. Piezo Voltage Controlled Planar Hall Effect Devices.

    PubMed

    Zhang, Bao; Meng, Kang-Kang; Yang, Mei-Yin; Edmonds, K W; Zhang, Hao; Cai, Kai-Ming; Sheng, Yu; Zhang, Nan; Ji, Yang; Zhao, Jian-Hua; Zheng, Hou-Zhi; Wang, Kai-You

    2016-01-01

    The electrical control of the magnetization switching in ferromagnets is highly desired for future spintronic applications. Here we report on hybrid piezoelectric (PZT)/ferromagnetic (Co2FeAl) devices in which the planar Hall voltage in the ferromagnetic layer is tuned solely by piezo voltages. The change of planar Hall voltage is associated with magnetization switching through 90° in the plane under piezo voltages. Room temperature magnetic NOT and NOR gates are demonstrated based on the piezo voltage controlled Co2FeAl planar Hall effect devices without the external magnetic field. Our demonstration may lead to the realization of both information storage and processing using ferromagnetic materials. PMID:27329068

  20. Piezo Voltage Controlled Planar Hall Effect Devices

    PubMed Central

    Zhang, Bao; Meng, Kang-Kang; Yang, Mei-Yin; Edmonds, K. W.; Zhang, Hao; Cai, Kai-Ming; Sheng, Yu; Zhang, Nan; Ji, Yang; Zhao, Jian-Hua; Zheng, Hou-Zhi; Wang, Kai-You

    2016-01-01

    The electrical control of the magnetization switching in ferromagnets is highly desired for future spintronic applications. Here we report on hybrid piezoelectric (PZT)/ferromagnetic (Co2FeAl) devices in which the planar Hall voltage in the ferromagnetic layer is tuned solely by piezo voltages. The change of planar Hall voltage is associated with magnetization switching through 90° in the plane under piezo voltages. Room temperature magnetic NOT and NOR gates are demonstrated based on the piezo voltage controlled Co2FeAl planar Hall effect devices without the external magnetic field. Our demonstration may lead to the realization of both information storage and processing using ferromagnetic materials. PMID:27329068

  1. Distributed control using linear momentum exchange devices

    NASA Technical Reports Server (NTRS)

    Sharkey, J. P.; Waites, Henry; Doane, G. B., III

    1987-01-01

    MSFC has successfully employed the use of the Vibrational Control of Space Structures (VCOSS) Linear Momentum Exchange Devices (LMEDs), which was an outgrowth of the Air Force Wright Aeronautical Laboratory (AFWAL) program, in a distributed control experiment. The control experiment was conducted in MSFC's Ground Facility for Large Space Structures Control Verification (GF/LSSCV). The GF/LSSCV's test article was well suited for this experiment in that the LMED could be judiciously placed on the ASTROMAST. The LMED placements were such that vibrational mode information could be extracted from the accelerometers on the LMED. The LMED accelerometer information was processed by the control algorithms so that the LMED masses could be accelerated to produce forces which would dampen the vibrational modes of interest. Experimental results are presented showing the LMED's capabilities.

  2. Bidirectional telemetry controller for neuroprosthetic devices.

    PubMed

    Sharma, Vishnu; McCreery, Douglas B; Han, Martin; Pikov, Victor

    2010-02-01

    We present versatile multifunctional programmable controller with bidirectional data telemetry, implemented using existing commercial microchips and standard Bluetooth protocol, which adds convenience, reliability, and ease-of-use to neuroprosthetic devices. Controller, weighing 190 g, is placed on animal's back and provides bidirectional sustained telemetry rate of 500 kb/s , allowing real-time control of stimulation parameters and viewing of acquired data. In continuously-active state, controller consumes approximately 420 mW and operates without recharge for 8 h . It features independent 16-channel current-controlled stimulation, allowing current steering; customizable stimulus current waveforms; recording of stimulus voltage waveforms and evoked neuronal responses with stimulus artifact blanking circuitry. Flexibility, scalability, cost-efficiency, and a user-friendly computer interface of this device allow use in animal testing for variety of neuroprosthetic applications. Initial testing of the controller has been done in a feline model of brainstem auditory prosthesis. In this model, the electrical stimulation is applied to the array of microelectrodes implanted in the ventral cochlear nucleus, while the evoked neuronal activity was recorded with the electrode implanted in the contralateral inferior colliculus. Stimulus voltage waveforms to monitor the access impedance of the electrodes were acquired at the rate of 312 kilosamples/s. Evoked neuronal activity in the inferior colliculus was recorded after the blanking (transient silencing) of the recording amplifier during the stimulus pulse, allowing the detection of neuronal responses within 100 mus after the end of the stimulus pulse applied in the cochlear nucleus. PMID:19933010

  3. 14 CFR 25.697 - Lift and drag devices, controls.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Lift and drag devices, controls. 25.697....697 Lift and drag devices, controls. (a) Each lift device control must be designed so that the pilots....101(d). Lift and drag devices must maintain the selected positions, except for movement produced by...

  4. 14 CFR 25.697 - Lift and drag devices, controls.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Lift and drag devices, controls. 25.697....697 Lift and drag devices, controls. (a) Each lift device control must be designed so that the pilots....101(d). Lift and drag devices must maintain the selected positions, except for movement produced by...

  5. 14 CFR 25.697 - Lift and drag devices, controls.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Lift and drag devices, controls. 25.697....697 Lift and drag devices, controls. (a) Each lift device control must be designed so that the pilots....101(d). Lift and drag devices must maintain the selected positions, except for movement produced by...

  6. 14 CFR 25.697 - Lift and drag devices, controls.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Lift and drag devices, controls. 25.697....697 Lift and drag devices, controls. (a) Each lift device control must be designed so that the pilots....101(d). Lift and drag devices must maintain the selected positions, except for movement produced by...

  7. 14 CFR 25.697 - Lift and drag devices, controls.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Lift and drag devices, controls. 25.697....697 Lift and drag devices, controls. (a) Each lift device control must be designed so that the pilots....101(d). Lift and drag devices must maintain the selected positions, except for movement produced by...

  8. MEMS device for spacecraft thermal control applications

    NASA Technical Reports Server (NTRS)

    Swanson, Theordore D. (Inventor)

    2003-01-01

    A micro-electromechanical device that comprises miniaturized mechanical louvers, referred to as Micro Electro-Mechanical Systems (MEMS) louvers are employed to achieve a thermal control function for spacecraft and instruments. The MEMS louvers are another form of a variable emittance control coating and employ micro-electromechanical technology. In a function similar to traditional, macroscopic thermal louvers, the MEMS louvers of the present invention change the emissivity of a surface. With the MEMS louvers, as with the traditional macroscopic louvers, a mechanical vane or window is opened and closed to allow an alterable radiative view to space.

  9. Modelling and Control of an Annular Momentum Control Device

    NASA Technical Reports Server (NTRS)

    Downer, James R.; Johnson, Bruce G.

    1988-01-01

    The results of a modelling and control study for an advanced momentum storage device supported on magnetic bearings are documented. The control challenge posed by this device lies in its dynamics being such a strong function of flywheel rotational speed. At high rotational speed, this can lead to open loop instabilities, resulting in requirements for minimum and maximum control bandwidths and gains for the stabilizing controllers. Using recently developed analysis tools for systems described by complex coefficient differential equations, the closed properties of the controllers were analyzed and stability properties established. Various feedback controllers are investigated and discussed. Both translational and angular dynamics compensators are developed, and measures of system stability and robustness to plant and operational speed variations are presented.

  10. Control device for prosthetic urinary sphincter cuff

    NASA Technical Reports Server (NTRS)

    Reinicke, Robert H. (Inventor)

    1983-01-01

    A device for controlling flow of fluid to and from a resilient inflatable cuff implanted about the urethra to control flow of urine therethrough. The device comprises a flexible bulb reservoir and a control unit that includes a manually operated valve that opens automatically when the bulb is squeezed to force fluid into the cuff for closing the urethra. The control unit also includes a movable valve seat member having a relatively large area exposed to pressure of fluid in a chamber that is connected to the cuff and which moves to a position in which the valve member is unseated by an abutment when fluid pressure in the chamber exceeds a predetermined value to thereby relieve excess fluid pressure in the cuff. The arrangement is such that the valve element is held closed against the seat member by the full differential in fluid pressures acting on both sides of the valve element until the seat member is moved away from the valve element to thus insure positive closing of the valve element until the seat member is moved out of engagement with the valve element by excess pressure differential.

  11. Ferrofluid Microwave Devices With Magnetically Controlled Impedances

    NASA Astrophysics Data System (ADS)

    Fannin, P. C.; Stefu, N.; Marin, C. N.; Malaescu, I.; Totoreanu, R.

    2010-08-01

    Ferrofluid filled transmission lines are microwave electronic devices. The complex dielectric permittivity and the complex magnetic permeability of a kerosene based ferrofluid with magnetite nanoparticles, in the frequency range (0.5-6) GHz were measured, for several values of polarising field, H. Afterwards, the input impedance of a short-circuited transmission line filled with this ferrofluid was computed using the equation Z = Zc tanh(γl). Here Zc and l are the characteristic impedance and the length of the coaxial line and γ is the propagation constant, depending on the dielectric and magnetic parameters of the material within the line. It is demonstrated how the impedance displays a frequency and polarizing field dependence, which has application in the design of magnetically controlled microwave devices.

  12. What’s next after metformin? focus on sulphonylurea: add-on or combination therapy

    PubMed Central

    Lim, Phei C.; Chong, Chee P.

    2015-01-01

    Introduction: The pathophysiology of type 2 diabetes (T2DM) mainly focused on insulin resistance and insulin deficiency over the past decades. Currently, the pathophysiologies expanded to ominous octet and guidelines were updated with newer generation of antidiabetic drug classes. However, many patients had yet to achieve their target glycaemic control. Although all the guidelines suggested metformin as first line, there was no definite consensus on the second line drug agents as variety of drug classes were recommended. Objectives: The aim of this review was to evaluate the drug class after metformin especially sulphonylurea and issues around add-on or fixed dose combination therapy. Methods: Extensive literature search for English language articles, clinical practice guidelines and references was performed using electronic databases. Results: Adding sulphonylurea to metformin targeted both insulin resistance and insulin deficiency. Sulphonylurea was efficacious and cheaper than thiazolidinedione, dipeptidyl peptidase-4 inhibitor, glucagon-like peptide 1 analogue and insulin. The main side effect of sulphonylurea was hypoglycaemia but there was no effect on the body weight when combining with metformin. Fixed dose sulphonylurea/metformin was more efficacious at lower dose and reported to have fewer side effects with better adherence. Furthermore, fixed dose combination was cheaper than add-on therapy. In conclusion, sulphonylurea was feasible as the second line agent after metformin as the combination targeted on two pathways, efficacious, cost-effective and had long safety history. Fixed dose combination tablet could improve patient’s adherence and offered an inexpensive and more efficacious option regardless of original or generic product as compared to add-on therapy. PMID:26445623

  13. Bidirectional Telemetry Controller for Neuroprosthetic Devices

    PubMed Central

    Sharma, Vishnu; McCreery, Douglas B.; Han, Martin; Pikov, Victor

    2010-01-01

    We present versatile multifunctional programmable controller with bidirectional data telemetry, implemented using existing commercial microchips and standard Bluetooth protocol, which adds convenience, reliability, and ease-of-use to neuroprosthetic devices. Controller, weighing 190 g, is placed on animal's back and provides bidirectional sustained telemetry rate of 500 kb/s, allowing real-time control of stimulation parameters and viewing of acquired data. In continuously-active state, controller consumes ∼420 mW and operates without recharge for 8 h. It features independent 16-channel current-controlled stimulation, allowing current steering; customizable stimulus current waveforms; recording of stimulus voltage waveforms and evoked neuronal responses with stimulus artifact blanking circuitry. Flexibility, scalability, cost-efficiency, and a user-friendly computer interface of this device allow use in animal testing for variety of neuroprosthetic applications. Initial testing of the controller has been done in a feline model of brainstem auditory prosthesis. In this model, the electrical stimulation is applied to the array of microelectrodes implanted in the ventral cochlear nucleus, while the evoked neuronal activity was recorded with the electrode implanted in the contralateral inferior colliculus. Stimulus voltage waveforms to monitor the access impedance of the electrodes were acquired at the rate of 312 kilosamples/s. Evoked neuronal activity in the inferior colliculus was recorded after the blanking (transient silencing) of the recording amplifier during the stimulus pulse, allowing the detection of neuronal responses within 100 μs after the end of the stimulus pulse applied in the cochlear nucleus. PMID:19933010

  14. Device Control Using Gestures Sensed from EMG

    NASA Technical Reports Server (NTRS)

    Wheeler, Kevin R.

    2003-01-01

    In this paper we present neuro-electric interfaces for virtual device control. The examples presented rely upon sampling Electromyogram data from a participants forearm. This data is then fed into pattern recognition software that has been trained to distinguish gestures from a given gesture set. The pattern recognition software consists of hidden Markov models which are used to recognize the gestures as they are being performed in real-time. Two experiments were conducted to examine the feasibility of this interface technology. The first replicated a virtual joystick interface, and the second replicated a keyboard.

  15. Electronic 4-wheel drive control device

    NASA Technical Reports Server (NTRS)

    Hayato, S.; Takanori, S.; Shigeru, H.; Tatsunori, S.

    1984-01-01

    The internal rotation torque generated during operation of a 4-wheel drive vehicle is reduced using a control device whose clutch is attached to one part of the rear-wheel drive shaft. One torque sensor senses the drive torque associated with the rear wheel drive shaft. A second sensor senses the drive torque associated with the front wheel drive shaft. Revolution count sensors sense the revolutions of each drive shaft. By means of a microcomputer, the engagement of the clutch is changed to insure that the ratio of the torque sensors remains constant.

  16. Gantry and isocenter displacements of a linear accelerator caused by an add-on micromultileaf collimator

    SciTech Connect

    Riis, Hans L.; Zimmermann, Sune J.; Hjelm-Hansen, Mogens

    2013-03-15

    Purpose: The delivery of high quality stereotactic radiosurgery (SRS) and stereotactic radiotherapy (SRT) treatments to the patient requires knowledge of the position of the isocenter to submillimeter accuracy. To meet the requirements the deviation between the radiation and mechanical isocenters must be less than 1 mm. The use of add-on micromultileaf collimators ({mu}MLCs) in SRS and SRT is an additional challenge to the anticipated high-level geometric and dosimetric accuracy of the treatment. The aim of this work was to quantify the gantry excursions during rotation with and without an add-on {mu}MLC attached to the gantry head. In addition, the shift in the position of the isocenter and its correlation to the kV beam center of the cone-beam CT system was included in the study. Methods: The quantification of the gantry rotational performance was done using a pointer supported by an in-house made rigid holder attached to the gantry head of the accelerator. The pointer positions were measured using a digital theodolite. To quantify the effect of an {mu}MLC of 50 kg, the measurements were repeated with the {mu}MLC attached to the gantry head. The displacement of the isocenter due to an add-on {mu}MLC of 50 kg was also investigated. In case of the pointer measurement the {mu}MLC was simulated by weights attached to the gantry head. A method of least squares was applied to determine the position and displacement of the mechanical isocenter. Additionally, the displacement of the radiation isocenter was measured using a ball-bearing phantom and the electronic portal image device system. These measurements were based on 8 MV photon beams irradiated onto the ball from the four cardinal angles and two opposed collimator angles. The measurements and analysis of the data were carried out automatically using software delivered by the manufacturer. Results: The displacement of the mechanical isocenter caused by a 50 kg heavy {mu}MLC was found to be (-0.01 {+-} 0.05, -0

  17. DSP control of superconducting quantum interference devices

    SciTech Connect

    Bracht, R.R.; Kung, Pang-Jen; Lewis, P.S.; Flynn, E.R.

    1994-08-01

    Superconducting quantum interference devices (SQUIDS) are used to defect very law level magnetic fields. Los Alamos National Laboratory is involved in developing digital signal processing (DSP) based instrumentation for these devices in conjunction with detecting magnetic flux from the human brain. This field of application is known as magnetoencephalography (MEG). The magnetic signals generated by the brain are on the order of a billion times smaller than the earth`s magnetic field, yet they can readily be detected with these highly ,sensitive magnetic detectors. Los Alamos National Laboratory has developed and implemented DSP control of the SQUID system. This has been accomplished by using an AT&T DSP32C DSP in conjunction with dual 18 bit a-to-d and d-to-a converters. The DSP performs the signal demodulation by synchronously sampling the recovered signal and applying the appropriate full wave rectification. The signal is then integrated and filtered and applied to the output. Also, the modulation signal is generated with the DSP system. All of the flux lock loop electronics are replaced except for the low noise analog preamplifier at the front of the recovery components. The system has been tested with both an electronic SQUID simulator and a low temperature thin film SQUID from Conductus. A number of experiments have been performed to allow evaluation of the system improvement made possible by use of DSP control.

  18. 40 CFR 65.155 - Other control devices.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 16 2014-07-01 2014-07-01 false Other control devices. 65.155 Section 65.155 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONSOLIDATED FEDERAL AIR RULE Closed Vent Systems, Control Devices, and Routing to a Fuel Gas System or a Process § 65.155 Other control devices....

  19. 14 CFR 25.373 - Speed control devices.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Speed control devices. 25.373 Section 25... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Structure Supplementary Conditions § 25.373 Speed control devices. If speed control devices (such as spoilers and drag flaps) are installed for use in en...

  20. 14 CFR 25.373 - Speed control devices.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Speed control devices. 25.373 Section 25... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Structure Supplementary Conditions § 25.373 Speed control devices. If speed control devices (such as spoilers and drag flaps) are installed for use in en...

  1. 14 CFR 25.373 - Speed control devices.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Speed control devices. 25.373 Section 25... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Structure Supplementary Conditions § 25.373 Speed control devices. If speed control devices (such as spoilers and drag flaps) are installed for use in en...

  2. 36 CFR 4.12 - Traffic control devices.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Traffic control devices. 4.12... VEHICLES AND TRAFFIC SAFETY § 4.12 Traffic control devices. Failure to comply with the directions of a traffic control device is prohibited unless otherwise directed by the superintendent....

  3. 36 CFR 1004.12 - Traffic control devices.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 3 2013-07-01 2012-07-01 true Traffic control devices. 1004.12 Section 1004.12 Parks, Forests, and Public Property PRESIDIO TRUST VEHICLES AND TRAFFIC SAFETY § 1004.12 Traffic control devices. Failure to comply with the directions of a traffic control device...

  4. 36 CFR 4.12 - Traffic control devices.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Traffic control devices. 4.12... VEHICLES AND TRAFFIC SAFETY § 4.12 Traffic control devices. Failure to comply with the directions of a traffic control device is prohibited unless otherwise directed by the superintendent....

  5. 36 CFR 1004.12 - Traffic control devices.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 3 2012-07-01 2012-07-01 false Traffic control devices. 1004.12 Section 1004.12 Parks, Forests, and Public Property PRESIDIO TRUST VEHICLES AND TRAFFIC SAFETY § 1004.12 Traffic control devices. Failure to comply with the directions of a traffic control device...

  6. 36 CFR 4.12 - Traffic control devices.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Traffic control devices. 4.12... VEHICLES AND TRAFFIC SAFETY § 4.12 Traffic control devices. Failure to comply with the directions of a traffic control device is prohibited unless otherwise directed by the superintendent....

  7. 36 CFR 1004.12 - Traffic control devices.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 3 2014-07-01 2014-07-01 false Traffic control devices. 1004.12 Section 1004.12 Parks, Forests, and Public Property PRESIDIO TRUST VEHICLES AND TRAFFIC SAFETY § 1004.12 Traffic control devices. Failure to comply with the directions of a traffic control device...

  8. 36 CFR 1004.12 - Traffic control devices.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 3 2011-07-01 2011-07-01 false Traffic control devices. 1004.12 Section 1004.12 Parks, Forests, and Public Property PRESIDIO TRUST VEHICLES AND TRAFFIC SAFETY § 1004.12 Traffic control devices. Failure to comply with the directions of a traffic control device...

  9. 36 CFR 4.12 - Traffic control devices.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Traffic control devices. 4.12... VEHICLES AND TRAFFIC SAFETY § 4.12 Traffic control devices. Failure to comply with the directions of a traffic control device is prohibited unless otherwise directed by the superintendent....

  10. 36 CFR 1004.12 - Traffic control devices.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Traffic control devices. 1004.12 Section 1004.12 Parks, Forests, and Public Property PRESIDIO TRUST VEHICLES AND TRAFFIC SAFETY § 1004.12 Traffic control devices. Failure to comply with the directions of a traffic control device...

  11. 36 CFR 4.12 - Traffic control devices.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Traffic control devices. 4.12... VEHICLES AND TRAFFIC SAFETY § 4.12 Traffic control devices. Failure to comply with the directions of a traffic control device is prohibited unless otherwise directed by the superintendent....

  12. 14 CFR 25.373 - Speed control devices.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Speed control devices. 25.373 Section 25... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Structure Supplementary Conditions § 25.373 Speed control devices. If speed control devices (such as spoilers and drag flaps) are installed for use in en...

  13. 14 CFR 25.373 - Speed control devices.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Speed control devices. 25.373 Section 25... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Structure Supplementary Conditions § 25.373 Speed control devices. If speed control devices (such as spoilers and drag flaps) are installed for use in en...

  14. 78 FR 36132 - National Standards for Traffic Control Devices; Manual on Uniform Traffic Control Devices for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-17

    ... January 11, 2013, the FHWA published a Request for Comments at 78 FR 2347 (Docket ID: FHWA-2012-0118...; Manual on Uniform Traffic Control Devices for Streets and Highways AGENCY: Federal Highway Administration (FHWA), DOT. ACTION: Notification; response to comments. SUMMARY: The Manual on Uniform Traffic...

  15. Device Configuration Handler for Accelerator Control Applications at Jefferson Lab

    SciTech Connect

    Matt Bickley; P. Chevtsov; T. Larrieu

    2003-10-01

    The accelerator control system at Jefferson Lab uses hundreds of physical devices with such popular instrument bus interfaces as Industry Pack (IPAC), GPIB, RS-232, etc. To properly handle all these components, control computers (IOCs) must be provided with the correct information about the unique memory addresses of the used interface cards, interrupt numbers (if any), data communication channels and protocols. In these conditions, the registration of a new control device in the control system is not an easy task for software developers. Because the device configuration is distributed, it requires the detailed knowledge about not only the new device but also the configuration of all other devices on the existing system. A configuration handler implemented at Jefferson Lab centralizes the information about all control devices making their registration user-friendly and very easy to use. It consists of a device driver framework and the device registration software developed on the basis of ORACLE database and freely available scripting tools (perl, php).

  16. Experimental re-evaluation of flunarizine as add-on antiepileptic therapy

    PubMed Central

    Thakur, Anamika; Sahai, A. K.; Thakur, J. S.

    2011-01-01

    Background: Experimental studies have found several calcium channel blockers with anticonvulsant property. Flunarizine is one of the most potent calcium channel blockers, which has shown anticonvulsant effect against pentylenetetrazole (PTZ) and maximal electroshock (MES)-induced seizures. However, further experimental and clinical trials have shown varied results. We conducted a PTZ model experimental study to re-evaluate the potential of flunarizine for add-on therapy in the management of refractory epilepsy. Materials and Methods: Experiments were conducted in PTZ model involving Swiss strain mice. Doses producing seizures in 50% and 99% mice, i.e. CD50 and CD99 values of PTZ were obtained from the dose-response study. Animals received graded, single dose of sodium valproate (100–300 mg/kg), lamotrigine (3–12 mg/kg) and flunarizine (5–20 mg/kg), and then each group of mice was injected with CD99 dose of PTZ (65mg/kg i.p.). Another group of mice received single ED50 dose (dose producing seizure protection in 50% mice) of sodium valproate and flunarizine separately in left and right side of abdomen. Results were analysed by Kruskal–Wallis ANOVA on Ranks test. Results: As compared to control, sodium valproate at 250 mg/kg and 300 mg/kg produced statistical significant seizure protection. At none of the pre-treatment dose levels of lamotrigine, the seizure score with PTZ differed significantly from that observed in the vehicle-treated group. Pre-treatment with flunarizine demonstrated dose-dependent decrease in the seizure score to PTZ administration. As compared to control group, flunarizine at 20 mg/kg produced statistical significant seizure protection. Conclusion: As combined use of sodium valproate and flunarizine has shown significant seizure protection in PTZ model, flunarizine has a potential for add-on therapy in refractory cases of partial seizures. It is therefore, we conclude that further experimental studies and multicenter clinical trials

  17. Celecoxib Adjunctive Treatment to Antipsychotics in Schizophrenia: A Review of Randomized Clinical Add-On Trials.

    PubMed

    Marini, Stefano; De Berardis, Domenico; Vellante, Federica; Santacroce, Rita; Orsolini, Laura; Valchera, Alessandro; Girinelli, Gabriella; Carano, Alessandro; Fornaro, Michele; Gambi, Francesco; Martinotti, Giovanni; Di Giannantonio, Massimo

    2016-01-01

    Schizophrenia is a severe, chronic and debilitating mental disorder. Past literature has reported various hypotheses about the psychopathology of schizophrenia. Recently, a growing literature has been trying to explain the role of inflammation in the etiopathogenesis of schizophrenia. In the past, numerous immune modulation and anti-inflammatory treatment options have been proposed for schizophrenia, but sometimes the results were inconsistent. Electronic search was carried out in November 2015. PubMed and Scopus databases have been used to find studies to introduce in this review. Only randomized-placebo-controlled add-on trials were taken into account. In this way, six articles were obtained for the discussion. Celecoxib showed beneficial effects mostly in early stages of schizophrenia. In chronic schizophrenia, the data are controversial, possibly in part for methodological reasons. PMID:27524864

  18. Celecoxib Adjunctive Treatment to Antipsychotics in Schizophrenia: A Review of Randomized Clinical Add-On Trials

    PubMed Central

    De Berardis, Domenico; Vellante, Federica; Santacroce, Rita; Orsolini, Laura; Valchera, Alessandro; Girinelli, Gabriella; Carano, Alessandro; Fornaro, Michele; Gambi, Francesco; Martinotti, Giovanni; Di Giannantonio, Massimo

    2016-01-01

    Schizophrenia is a severe, chronic and debilitating mental disorder. Past literature has reported various hypotheses about the psychopathology of schizophrenia. Recently, a growing literature has been trying to explain the role of inflammation in the etiopathogenesis of schizophrenia. In the past, numerous immune modulation and anti-inflammatory treatment options have been proposed for schizophrenia, but sometimes the results were inconsistent. Electronic search was carried out in November 2015. PubMed and Scopus databases have been used to find studies to introduce in this review. Only randomized-placebo-controlled add-on trials were taken into account. In this way, six articles were obtained for the discussion. Celecoxib showed beneficial effects mostly in early stages of schizophrenia. In chronic schizophrenia, the data are controversial, possibly in part for methodological reasons. PMID:27524864

  19. Adaptive control system for large annular momentum control device

    NASA Technical Reports Server (NTRS)

    Montgomery, R. C.; Johnson, C. R., Jr.

    1981-01-01

    A dual momentum vector control concept, consisting of two counterrotating rings (each designated as an annular momentum control device), was studied for pointing and slewing control of large spacecraft. In a disturbance free space environment, the concept provides for three axis pointing and slewing capabilities while requiring no expendables. The approach utilizes two large diameter counterrotating rings or wheels suspended magnetically in many race supports distributed around the antenna structure. When the magnets are energized, attracting the two wheels, the resulting gyroscopic torque produces a rate along the appropriate axis. Roll control is provided by alternating the radiative rotational velocity of the two wheels. Wheels with diameters of 500 to 800 m and with sufficient momentum storage capability require rims only a few centimeters thick. The wheels are extremely flexible; therefore, it is necessary to account for the distributed nature of the rings in the design of the bearing controllers. Also, ring behavior is unpredictably sensitive to ring temperature, spin rate, manufacturing imperfections, and other variables. An adaptive control system designed to handle these problems is described.

  20. 49 CFR 178.338-11 - Discharge control devices.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Specifications for Containers for Motor Vehicle Transportation § 178.338-11 Discharge control devices. (a) Excess... control system. (ii) On a cargo tank motor vehicle of 3,500 gallons water capacity or less, at least one... 49 Transportation 3 2011-10-01 2011-10-01 false Discharge control devices. 178.338-11 Section...

  1. Efficacy and safety of muscarinic antagonists as add-on therapy for male lower urinary tract symptoms

    PubMed Central

    Li, Jinhong; Shi, Qingquan; Bai, Yunjin; Pu, Chunxiao; Tang, Yin; Yuan, Haichao; Wu, Yunjian; Wei, Qiang; Han, Ping

    2014-01-01

    Alpha-adrenoceptor antagonists (alpha-blockers) are widely prescribed to treat lower urinary tract symptoms (LUTS) in men but fail to ameliorate LUTS sufficiently, especially the storage symptoms related to frequency, urgency and nocturia. We performed a meta-analysis of randomised controlled trials (RCTs) comparing an alpha-blocker plus muscarinic antagonist with an alpha-blocker alone in male LUTS patients who were treated with alpha-blocker prior to randomisation. The review contained six randomised controlled trials (RCTs) that included a total of 2,208 male patients who were randomised to receive alpha-blocker plus muscarinic antagonist or alpha-blocker alone. The add-on group experienced significantly greater improvement in both total IPSS (International Prostate Symptom Score) and storage IPSS. Adverse events (AEs) were commonly experienced by both groups (41.6 vs. 33.3%) though they were not severe. Our meta-analysis indicated that muscarinic antagonists as add-on therapy alleviate LUTS, especially storage symptoms. The add-on therapy demonstrated safety and tolerability comparable with alpha-blocker monotherapy in male with LUTS. PMID:24492830

  2. Quality Control On Strained Semiconductor Devices

    SciTech Connect

    Dommann, Alex; Neels, Antonia

    2010-11-24

    New semiconductor devices are based very often on strained silicon which promises to squeeze more device performance out of current devices. With strained silicon it is possible to get the same device performance using less power. The technique is using strain as a 'design element' for silicon to improve the device performance and has become a hot topic in semiconductor research in the past years. However in the same time topics like 'System in Package'(SiP) on thin wafers are getting more and more important. The chips of thin wafers in advanced packaging are extremely sensitive to induced stresses due to packaging issues. If we are using now strain as a design element for improving device performance we increase the sensitivity again and therefore also the risk of aging of such SiP's. High Resolution X-ray diffraction (HRXRD) techniques such as Rocking Curves (RC's) and Reciprocal Space Mapping (RSM) are therefore very powerful tools to study the stresses in packaged devices.

  3. 40 CFR 65.155 - Other control devices.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... requirements specified in § 65.63(a)(2), or 40 CFR 60.562-1(a)(1)(i)(A) for process vents, or § 65.83(a)(1) for... a control device to replace an existing recovery device that is used on a Group 2A process vent, the... 40 Protection of Environment 16 2012-07-01 2012-07-01 false Other control devices. 65.155...

  4. 40 CFR 65.155 - Other control devices.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... requirements specified in § 65.63(a)(2), or 40 CFR 60.562-1(a)(1)(i)(A) for process vents, or § 65.83(a)(1) for... a control device to replace an existing recovery device that is used on a Group 2A process vent, the... 40 Protection of Environment 15 2010-07-01 2010-07-01 false Other control devices. 65.155...

  5. 40 CFR 65.155 - Other control devices.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... requirements specified in § 65.63(a)(2), or 40 CFR 60.562-1(a)(1)(i)(A) for process vents, or § 65.83(a)(1) for... a control device to replace an existing recovery device that is used on a Group 2A process vent, the... 40 Protection of Environment 15 2011-07-01 2011-07-01 false Other control devices. 65.155...

  6. 40 CFR 65.155 - Other control devices.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... requirements specified in § 65.63(a)(2), or 40 CFR 60.562-1(a)(1)(i)(A) for process vents, or § 65.83(a)(1) for... a control device to replace an existing recovery device that is used on a Group 2A process vent, the... 40 Protection of Environment 16 2013-07-01 2013-07-01 false Other control devices. 65.155...

  7. FINE PARTICLE CONTROL TECHNOLOGY: CONVENTIONAL AND NOVEL DEVICES

    EPA Science Inventory

    This paper reviews the development of technology in fine particle control. Electrostatic precipitators (ESPs), scrubbers, fabric filters, and novel devices were assessed to determine their efficiency. ESPs were found to be excellent in controlling fine particles: with an efficien...

  8. 30 CFR 75.330 - Face ventilation control devices.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Face ventilation control devices. 75.330 Section 75.330 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL MINE SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Ventilation § 75.330 Face ventilation control devices. (a) Brattice cloth,...

  9. 40 CFR 65.151 - Condensers used as control devices.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... parts per million by volume outlet concentration requirements as specified in § 65.63(a)(2), or 40 CFR... control device on a Group 1 process vent or a high-throughput transfer rack with a condenser used as a... 40 Protection of Environment 15 2011-07-01 2011-07-01 false Condensers used as control devices....

  10. 40 CFR 65.150 - Absorbers used as control devices.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 16 2014-07-01 2014-07-01 false Absorbers used as control devices. 65.150 Section 65.150 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONSOLIDATED FEDERAL AIR RULE Closed Vent Systems, Control Devices, and Routing to a Fuel Gas System or a Process § 65.150...

  11. 40 CFR 65.150 - Absorbers used as control devices.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... parts per million by volume outlet concentration requirements as specified in § 65.63(a)(2), or 40 CFR... control device on a Group 1 process vent or a high-throughput transfer rack with an absorber used as a... 40 Protection of Environment 15 2011-07-01 2011-07-01 false Absorbers used as control devices....

  12. 40 CFR 65.151 - Condensers used as control devices.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... parts per million by volume outlet concentration requirements as specified in § 65.63(a)(2), or 40 CFR... control device on a Group 1 process vent or a high-throughput transfer rack with a condenser used as a... 40 Protection of Environment 15 2010-07-01 2010-07-01 false Condensers used as control devices....

  13. 40 CFR 65.151 - Condensers used as control devices.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 16 2014-07-01 2014-07-01 false Condensers used as control devices. 65.151 Section 65.151 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONSOLIDATED FEDERAL AIR RULE Closed Vent Systems, Control Devices, and Routing to a Fuel Gas System or a Process § 65.151...

  14. 40 CFR 65.150 - Absorbers used as control devices.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... parts per million by volume outlet concentration requirements as specified in § 65.63(a)(2), or 40 CFR... control device on a Group 1 process vent or a high-throughput transfer rack with an absorber used as a... 40 Protection of Environment 15 2010-07-01 2010-07-01 false Absorbers used as control devices....

  15. 49 CFR 236.501 - Forestalling device and speed control.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Forestalling device and speed control. 236.501... Train Stop, Train Control and Cab Signal Systems Standards § 236.501 Forestalling device and speed... the following features: (1) Low-speed restriction, requiring the train to proceed under slow...

  16. 49 CFR 236.501 - Forestalling device and speed control.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Forestalling device and speed control. 236.501... Train Stop, Train Control and Cab Signal Systems Standards § 236.501 Forestalling device and speed... the following features: (1) Low-speed restriction, requiring the train to proceed under slow...

  17. 49 CFR 236.501 - Forestalling device and speed control.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Forestalling device and speed control. 236.501... Train Stop, Train Control and Cab Signal Systems Standards § 236.501 Forestalling device and speed... the following features: (1) Low-speed restriction, requiring the train to proceed under slow...

  18. Variable control of neutron albedo in toroidal fusion devices

    DOEpatents

    Jassby, D.L.; Micklich, B.J.

    1983-06-01

    This invention pertains to methods of controlling in the steady state, neutron albedo in toroidal fusion devices, and in particular, to methods of controlling the flux and energy distribution of collided neutrons which are incident on an outboard wall of a toroidal fusion device.

  19. 40 CFR 65.150 - Absorbers used as control devices.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... parts per million by volume outlet concentration requirements as specified in § 65.63(a)(2), or 40 CFR... 40 Protection of Environment 16 2013-07-01 2013-07-01 false Absorbers used as control devices. 65... System or a Process § 65.150 Absorbers used as control devices. (a) Absorber equipment and...

  20. 40 CFR 65.151 - Condensers used as control devices.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... parts per million by volume outlet concentration requirements as specified in § 65.63(a)(2), or 40 CFR... 40 Protection of Environment 16 2013-07-01 2013-07-01 false Condensers used as control devices. 65... System or a Process § 65.151 Condensers used as control devices. (a) Condenser equipment and...

  1. 49 CFR 236.501 - Forestalling device and speed control.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Forestalling device and speed control. 236.501... Train Stop, Train Control and Cab Signal Systems Standards § 236.501 Forestalling device and speed... the following features: (1) Low-speed restriction, requiring the train to proceed under slow...

  2. 49 CFR 236.501 - Forestalling device and speed control.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Forestalling device and speed control. 236.501... Train Stop, Train Control and Cab Signal Systems Standards § 236.501 Forestalling device and speed... the following features: (1) Low-speed restriction, requiring the train to proceed under slow...

  3. Effect and Potential Mechanism of Electroacupuncture Add-On Treatment in Patients with Parkinson's Disease.

    PubMed

    Wang, Fang; Sun, Li; Zhang, Xiao-Zhe; Jia, Jun; Liu, Zhuo; Huang, Xi-Yan; Yu, Shu-Yang; Zuo, Li-Jun; Cao, Chen-Jie; Wang, Xiao-Min; Zhang, Wei

    2015-01-01

    Objectives. To explore effectiveness and mechanisms of electroacupuncture (EA) add-on treatment in Parkinson's disease (PD) patients. Methods. Fifty PD patients were randomly assigned to drug plus EA (D + EA) group and drug alone (D) group. Subjects in D + EA group received stimulation in points of bilateral fengfu, fengchi, hegu, and central dazhui. Participants were evaluated by scales for motor and nonmotor symptoms. Levels of neuroinflammatory factors and neurotransmitters in serum were detected. Results. EA add-on treatment remarkably reduced scores of Unified Parkinson's Disease Rating Scale (UPDRS) III and its subitems of tremor, rigidity, and bradykinesia and conspicuously decreased UPDRS III scores in patients with bradykinesia-rigidity and mixed types and mild severity. Depression and sleep disturbances were eased, which were reflected by decreased scores of Hamilton Depression Rating Scale, Pittsburgh Sleep Quality Index, and elevated noradrenaline level. Effects of EA add-on treatment on motor symptoms and sleep disturbances were superior to drug alone treatment, markedly improving life quality of PD patients. EA add-on treatment decreased nitric oxide level in serum. Conclusions. EA add-on treatment is effective on most motor symptoms and some nonmotor symptoms and is particularly efficacious in PD patients at early stage. Antineuroinflammation may be a mechanism of EA add-on treatment. PMID:26351515

  4. Determining Desirable Cursor Control Device Characteristics for NASA Exploration Missions

    NASA Technical Reports Server (NTRS)

    Sandor, Aniko; Holden, Kritina L.

    2007-01-01

    A test battery was developed for cursor control device evaluation: four tasks were taken from ISO 9241-9, and three from previous studies conducted at NASA. The tasks focused on basic movements such as pointing, clicking, and dragging. Four cursor control devices were evaluated with and without Extravehicular Activity (EVA) gloves to identify desirable cursor control device characteristics for NASA missions: 1) the Kensington Expert Mouse, 2) the Hulapoint mouse, 3) the Logitech Marble Mouse, and 4) the Honeywell trackball. Results showed that: 1) the test battery is an efficient tool for differentiating among input devices, 2) gloved operations were about 1 second slower and had at least 15% more errors; 3) devices used with gloves have to be larger, and should allow good hand positioning to counteract the lack of tactile feedback, 4) none of the devices, as designed, were ideal for operation with EVA gloves.

  5. Development of an autonomous 32-bit intelligent device controller

    NASA Astrophysics Data System (ADS)

    Bishop, D.; Waters, G.; Dale, D.; Ewert, T.; Harrison, D.; Lam, J.; Keitel, R.

    1994-12-01

    This paper describes the development and present status of an intelligent device controller for embedded systems. The controller is a low-cost single-board module in Euro-card format based on a Motorola MC68332 microcontroller. An onboard Ethernet interface allows software downloading and remote device control. Also included are 12 ADC channels, 4 DAC channels, 56 bits of digital I/O and 3 serial ports. Custom modules may be added using a backplane bus. The controller is designed to function as a VME slave device. A multitasking environment is provided by the VxWorks kernel.

  6. 78 FR 2347 - National Standards for Traffic Control Devices; the Manual on Uniform Traffic Control Devices for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-11

    ...The Manual on Uniform Traffic Control Devices (MUTCD) is incorporated in our regulations, approved by the Federal Highway Administration, and recognized as the national standard for traffic control devices used on all streets, highways, bikeways, and private roads open to public travel. Consistent with Executive Order 13563, and in particular its emphasis on burden-reduction and on......

  7. Linear optimal control of tokamak fusion devices

    SciTech Connect

    Kessel, C.E.; Firestone, M.A.; Conn, R.W.

    1989-05-01

    The control of plasma position, shape and current in a tokamak fusion reactor is examined using linear optimal control. These advanced tokamaks are characterized by non up-down symmetric coils and structure, thick structure surrounding the plasma, eddy currents, shaped plasmas, superconducting coils, vertically unstable plasmas, and hybrid function coils providing ohmic heating, vertical field, radial field, and shaping field. Models of the electromagnetic environment in a tokamak are derived and used to construct control gains that are tested in nonlinear simulations with initial perturbations. The issues of applying linear optimal control to advanced tokamaks are addressed, including complex equilibrium control, choice of cost functional weights, the coil voltage limit, discrete control, and order reduction. Results indicate that the linear optimal control is a feasible technique for controlling advanced tokamaks where the more common classical control will be severely strained or will not work. 28 refs., 13 figs.

  8. Gravity controlled anti-reverse rotation device

    DOEpatents

    Dickinson, Robert J.; Wetherill, Todd M.

    1983-01-01

    A gravity assisted anti-reverse rotation device for preventing reverse rotation of pumps and the like. A horizontally mounted pawl is disposed to mesh with a fixed ratchet preventing reverse rotation when the pawl is advanced into intercourse with the ratchet by a vertically mounted lever having a lumped mass. Gravitation action on the lumped mass urges the pawl into mesh with the ratchet, while centrifugal force on the lumped mass during forward, allowed rotation retracts the pawl away from the ratchet.

  9. A Mechanical Decision-Making Device for Structural Control

    NASA Astrophysics Data System (ADS)

    Hsu, Deh-Shiu; Hou, Chien-Yuan; Yeh, Ming-Chang; Yeh, Chiu-Shang

    2002-11-01

    In the present study a new. mechanical. decision-making device is proposed for structural control. When a structure is excited by external loadings or around accelerations, the structural sides-way can be detected by the device, and control forces are provided or released if pre-defined conditions are fulfilled. Mathematical results show that structures mounted with the device exhibit less dynamic response when the structures are Subjected to earthquake excitations. Preliminary model test results showed that tile device is useful. Howe it has a much less efficiency than predicted by the mathematical model. This device is more reliable and is cost saving because the device is a machine without complex and expensive electronic facilities.

  10. Long-acting muscarinic antagonists: a potential add-on therapy in the treatment of asthma?

    PubMed

    Busse, William W; Dahl, Ronald; Jenkins, Christine; Cruz, Alvaro A

    2016-03-01

    Asthma is a chronic inflammatory disorder of the airways that is a major global burden on both individuals and healthcare systems. Despite guideline-directed treatment, a significant proportion of patients with asthma do not achieve control. This review focuses on the potential use of long-acting anticholinergics as bronchodilators in the treatment of asthma, with results published from clinical trials of glycopyrrolate, umeclidinium and tiotropium. The tiotropium clinical trial programme is the most advanced, with data available from a number of phase II and III studies of tiotropium as an add-on to inhaled corticosteroid maintenance therapy, with or without a long-acting β2-agonist, in patients across asthma severities. Recent studies using the Respimat Soft Mist inhaler have identified 5 µg once daily as the preferred dosing regimen, which has shown promising results in adults, adolescents and children with asthma. Tiotropium Respimat has recently been incorporated into the Global Initiative for Asthma 2015 treatment strategy as a recommended alternative therapy at steps 4 and 5 in adult patients with a history of exacerbations. The increasing availability of evidence from ongoing and future clinical trials will be beneficial in determining where long-acting anticholinergic agents fit in future treatment guidelines across a variety of patient populations and disease severities. PMID:26929422

  11. An Optically Controllable Transformation-dc Illusion Device.

    PubMed

    Jiang, Wei Xiang; Luo, Chen Yang; Ge, Shuo; Qiu, Cheng-Wei; Cui, Tie Jun

    2015-08-19

    The concept of multifunctional transformation-dc devices is proposed and verified experimentally. The functions of dc metamaterials can be remotely altered by illuminating with visible light. If the light-induced dc illusion effect is activated, the electrostatic behavior of the original object is perceived as multiple equivalent objects with different pre-designed geometries. The experimental verification of the functional device makes it possible to control sophisticated transformation-dc devices with external light illumination. PMID:26177597

  12. Smart Rehabilitation Devices: Part I – Force Tracking Control

    PubMed Central

    Dong, Shufang; Lu, Ke-Qian; Sun, J. Q.; Rudolph, Katherine

    2008-01-01

    Resistance exercise has been widely reported to have positive rehabilitation effects for patients with neuromuscular and orthopaedic conditions. This article presents prototypes of smart variable resistance exercise devices using magneto-rheological fluid dampers. An intelligent supervisory control for regulating the resistive force or torque of the device is developed, and is validated both numerically and experimentally. The device provides both isometric and isokinetic strength training for the human joints including knee, elbow, hip, and ankle. PMID:18504509

  13. Migrated Essure permanent birth control device: sonographic findings.

    PubMed

    Khati, Nadia Juliet; Gorodenker, Joseph; Brindle, Kathleen Ann

    2014-05-01

    We report a case of a migrated Essure permanent birth control device. The correct diagnosis was made on conventional two-dimensional and three-dimensional pelvic sonography 7 years after placement of the device when the patient presented with persistent right-sided pain. The 3-month post placement hysterosalpingogram had shown an appropriately occluded right fallopian tube but had overlooked the abnormal position of the right Essure device, which was too proximal and extending slightly in the uterine cavity. PMID:24122949

  14. Controllable optical transparency using an acoustic standing-wave device

    NASA Astrophysics Data System (ADS)

    Moradi, Kamran; El-Zahab, Bilal

    2015-09-01

    In this paper, a suspended-particle device with controllable light transmittance was developed based on acoustic stimuli. Using a glass compartment and carbon particle suspension in an organic solvent, the device responded to acoustic stimulation by alignment of particles. The alignment of light-absorbing carbon particles afforded an increase in light transmittance as high as 84.5% and was controllable based on the control of the frequency and amplitude of the acoustic waves. The device also demonstrated alignment memory rendering it energy-efficient.

  15. Smart Rehabilitation Devices: Part II – Adaptive Motion Control

    PubMed Central

    Dong, Shufang; Lu, Ke-Qian; Sun, J. Q.; Rudolph, Katherine

    2008-01-01

    This article presents a study of adaptive motion control of smart versatile rehabilitation devices using MR fluids. The device provides both isometric and isokinetic strength training and is reconfigurable for several human joints. Adaptive controls are developed to regulate resistance force based on the prescription of the therapist. Special consideration has been given to the human–machine interaction in the adaptive control that can modify the behavior of the device to account for strength gains or muscle fatigue of the human subject. PMID:18548131

  16. Self-regulating flow control device

    DOEpatents

    Humphreys, Duane A.

    1984-01-01

    A variable, self-regulating valve having a hydraulic loss coefficient proportional to a positive exponential power of the flow rate. The device includes two objects in a flow channel and structure which assures that the distance between the two objects is an increasing function of the flow rate. The range of spacing between the objects is such that the hydraulic resistance of the valve is an increasing function of the distance between the two objects so that the desired hydraulic loss coefficient as a function of flow rate is obtained without variation in the flow area.

  17. LAM actuated propellant flow control device

    NASA Astrophysics Data System (ADS)

    Reinicke, Robert H.; Cust, Kevin M.

    1992-02-01

    An advanced design LAM (limited angle motor) positions an integral flow control element for bi-level flow control of storable propellants. The LAM incorporates permanent magnet latching to maintain the flow control element in either the low or high flow position without continuous electrical energization. The LAM stator and rotor are fully sheathed within stainless steel. This construction method permits the LAM to control storable propellants without using dynamic seals to isolate the LAM from the propellants. All welded construction prevents external leakage. The design concept selection rationale and the computer FEA (finite element analysis) methods employed to optimize design characteristics are presented. Correlations of analyses to test results are described.

  18. Inverted Control Rod Lock-In Device

    DOEpatents

    Brussalis, W. G.; Bost, G. E.

    1962-12-01

    A mechanism which prevents control rods from dropping out of the reactor core in the event the vessel in which the reactor is mounted should capsize is described. The mechanism includes a pivoted toothed armature which engages the threaded control rod lead screw and prevents removal of the rod whenever the armature is not attracted by the provided electromagnetic means. (AEC)

  19. Control of impurities in toroidal plasma devices

    DOEpatents

    Ohkawa, Tihiro

    1980-01-01

    A method and apparatus for plasma impurity control in closed flux plasma systems such as Tokamak reactors is disclosed. Local axisymmetrical injection of hydrogen gas is employed to reverse the normally inward flow of impurities into the plasma.

  20. DESIGN MANUAL: SWIRL AND HELICAL BEND POLLUTION CONTROL DEVICES

    EPA Science Inventory

    This design manual contains descriptions of design procedures and operating experience to date, including results obtained, for secondary flow pollution control devices. Two types of combined sewer overflow regulators are described: the swirl and the helical bend regulator/separa...

  1. Sensitivity analysis of add-on price estimate for select silicon wafering technologies

    NASA Technical Reports Server (NTRS)

    Mokashi, A. R.

    1982-01-01

    The cost of producing wafers from silicon ingots is a major component of the add-on price of silicon sheet. Economic analyses of the add-on price estimates and their sensitivity internal-diameter (ID) sawing, multiblade slurry (MBS) sawing and fixed-abrasive slicing technique (FAST) are presented. Interim price estimation guidelines (IPEG) are used for estimating a process add-on price. Sensitivity analysis of price is performed with respect to cost parameters such as equipment, space, direct labor, materials (blade life) and utilities, and the production parameters such as slicing rate, slices per centimeter and process yield, using a computer program specifically developed to do sensitivity analysis with IPEG. The results aid in identifying the important cost parameters and assist in deciding the direction of technology development efforts.

  2. Improving the Laboratory Add-On Process and Increasing Housestaff Satisfaction with an EMR Intervention

    PubMed Central

    Shahnazarian, Vahe; Mehta, Parag

    2016-01-01

    At a community hospital in Brooklyn, New York, the process for ordering add-on testing to drawn blood tubes involved filling out a paper sheet, then faxing and bulleting that sheet to the lab. It was a very inefficient, cumbersome, and unsatisfactory way of completing the process. In light of this, an EMR intervention was implemented in which the add-on order was placed as an EMR order. The study spanned over almost five years, over a year of which was post-intervention. There was a statistically significant increase in the number of add-on orders being placed as a result of the intervention. This has greatly improved housestaff satisfaction with the overall process. In conclusion, the project was a great success and met its goals of simplifying a difficult and cumbersome process while increasing user satisfaction. PMID:27239309

  3. Molecular gels-based controlled release devices for pheromones

    Technology Transfer Automated Retrieval System (TEKTRAN)

    2-Heptanone is a volatile solvent that is effective in controlling parasitic mites (Varroa) in honeybee. Controlled-release of 2-heptanone is needed to avoid overdosing, minimize chemical usage, and provide a sustained release over a several week period. Control-release devices comprised of a reserv...

  4. The dynamics and control of a haptic interface device

    SciTech Connect

    Kazerooni, H. . Mechanical Engineering Dept.); Her, M.G. . Dept. of Mechanical Engineering)

    1994-08-01

    Haptic Interface Devices are machines that are controlled by the human arm contact forces. These devices are necessary elements of virtual reality machines. These devices may be programmed to give the human arm the sensation of forces associated with various arbitrary maneuvers. As examples, these devices can give the human the sensation that he/she is maneuvering a mass, or pushing onto a spring or a damper. In general, these devices may be programmed for any trajectory-dependant force. To illustrate and verify the analysis of these machines, a two-degree-of-freedom electrically-powered haptic interface device was designed and built at the Human Engineering Laboratory (HEL) of the University of California-Berkeley.

  5. Optically controlled multiple switching operations of DNA biopolymer devices

    NASA Astrophysics Data System (ADS)

    Hung, Chao-You; Tu, Waan-Ting; Lin, Yi-Tzu; Fruk, Ljiljana; Hung, Yu-Chueh

    2015-12-01

    We present optically tunable operations of deoxyribonucleic acid (DNA) biopolymer devices, where a single high-resistance state, write-once read-many-times memory state, write-read-erase memory state, and single low-resistance state can be achieved by controlling UV irradiation time. The device is a simple sandwich structure with a spin-coated DNA biopolymer layer sandwiched by two electrodes. Upon irradiation, the electrical properties of the device are adjusted owing to a phototriggered synthesis of silver nanoparticles in DNA biopolymer, giving rise to multiple switching scenarios. This technique, distinct from the strategy of doping of pre-formed nanoparticles, enables a post-film fabrication process for achieving optically controlled memory device operations, which provides a more versatile platform to fabricate organic memory and optoelectronic devices.

  6. Optically controlled multiple switching operations of DNA biopolymer devices

    SciTech Connect

    Hung, Chao-You; Tu, Waan-Ting; Lin, Yi-Tzu; Fruk, Ljiljana; Hung, Yu-Chueh

    2015-12-21

    We present optically tunable operations of deoxyribonucleic acid (DNA) biopolymer devices, where a single high-resistance state, write-once read-many-times memory state, write-read-erase memory state, and single low-resistance state can be achieved by controlling UV irradiation time. The device is a simple sandwich structure with a spin-coated DNA biopolymer layer sandwiched by two electrodes. Upon irradiation, the electrical properties of the device are adjusted owing to a phototriggered synthesis of silver nanoparticles in DNA biopolymer, giving rise to multiple switching scenarios. This technique, distinct from the strategy of doping of pre-formed nanoparticles, enables a post-film fabrication process for achieving optically controlled memory device operations, which provides a more versatile platform to fabricate organic memory and optoelectronic devices.

  7. Optimization of a fluidic temperature control device

    NASA Technical Reports Server (NTRS)

    Zabsky, J. M.; Rask, D. R.; Starr, J. B.

    1970-01-01

    Refinements are described to an existing fluidic temperature control system developed under a prior study which modulated temperature at the inlet to the liquid-cooled garment by using existing liquid supply and return lines to transmit signals to a fluidic controller located in the spacecraft. This earlier system produced a limited range of garment inlet temperatures, requiring some bypassing of flow around the suit to make the astronaut comfortable at rest conditions. Refinements were based on a flow visualization study of the key element in the fluidic controller: the fluidic mixing valve. The valve's mixing-ratio range was achieved by making five key changes: (1) geometrical changes to the valve; (2) attenuation of noise generated in proportional amplifier cascades; (3) elimination of vortices at the exit of the fluidic mixing valve; (4) reduction of internal heat transfer; and (5) flow balancing through venting. As a result, the refined system is capable of modulating garment inlet temperature from 45 F to 70 F with a single manual control valve in series with the garment. This control valve signals without changing or bypassing flow through the garment.

  8. 76 FR 46213 - National Standards for Traffic Control Devices; the Manual on Uniform Traffic Control Devices for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-02

    ... compromised based on engineering judgment or engineering study.'' \\1\\ 74 FR 66732, December 16, 2009. This... numbered accordingly. \\2\\ 75 FR 20935, April 22, 2010. This Federal Register notice can be viewed at the... Devices; the Manual on Uniform Traffic Control Devices for Streets and Highways; Revision AGENCY:...

  9. 75 FR 20935 - National Standards for Traffic Control Devices; the Manual on Uniform Traffic Control Devices for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-22

    ... Printing Office's Web page at: http://www.access.gpo.gov/nara . Background On December 21, 2007, at 72 FR... retroreflectivity final rule was published in the Federal Register at 72 FR 72574 on December 21, 2007, and can be... Devices; the Manual on Uniform Traffic Control Devices for Streets and Highways; Maintaining...

  10. DEVICE FOR CONTROLLING INSERTION OF ROD

    DOEpatents

    Beaty, B.J.

    1958-10-14

    A device for rapidly inserting a safety rod into a nuclear reactor upon a given signal or in the event of a power failure in order to prevent the possibility of extensive damage caused by a power excursion is described. A piston is slidably mounted within a vertical cylinder with provision for an electromagnetic latch at the top of the cylinder. This assembly, with a safety rod attached to the piston, is mounted over an access port to the core region of the reactor. The piston is normally latched at the top of the cylinder with the safety rod clear of the core area, however, when the latch is released, the piston and rod drop by their own weight to insert the rod. Vents along the side of the cylinder permit the escape of the air entrapped under the piston over the greater part of the distance, however, at the end of the fall the entrapped air is compressed thereby bringing the safety rod gently to rest, thus providing for a rapid automatic insertion of the rod with a minimum of structural shock.

  11. Implementation of Adaptive Digital Controllers on Programmable Logic Devices

    NASA Technical Reports Server (NTRS)

    Gwaltney, David A.; King, Kenneth D.; Smith, Keary J.; Montenegro, Justino (Technical Monitor)

    2002-01-01

    Much has been made of the capabilities of Field Programmable Gate Arrays (FPGA's) in the hardware implementation of fast digital signal processing functions. Such capability also makes an FPGA a suitable platform for the digital implementation of closed loop controllers. Other researchers have implemented a variety of closed-loop digital controllers on FPGA's. Some of these controllers include the widely used Proportional-Integral-Derivative (PID) controller, state space controllers, neural network and fuzzy logic based controllers. There are myriad advantages to utilizing an FPGA for discrete-time control functions which include the capability for reconfiguration when SRAM- based FPGA's are employed, fast parallel implementation of multiple control loops and implementations that can meet space level radiation tolerance requirements in a compact form-factor. Generally, a software implementation on a Digital Signal Processor (DSP) device or microcontroller is used to implement digital controllers. At Marshall Space Flight Center, the Control Electronics Group has been studying adaptive discrete-time control of motor driven actuator systems using DSP devices. While small form factor, commercial DSP devices are now available with event capture, data conversion, Pulse Width Modulated (PWM) outputs and communication peripherals, these devices are not currently available in designs and packages which meet space level radiation requirements. In general, very few DSP devices are produced that are designed to meet any level of radiation tolerance or hardness. An alternative is required for compact implementation of such functionality to withstand the harsh environment encountered on spacemap. The goal of this effort is to create a fully digital, flight ready controller design that utilizes an FPGA for implementation of signal conditioning for control feedback signals, generation of commands to the controlled system, and hardware insertion of adaptive-control algorithm

  12. Xiaoqinglong Granules as Add-On Therapy for Asthma: Latent Class Analysis of Symptom Predictors of Response

    PubMed Central

    Zha, Qinglin; Lin, Seqi; Zhang, Chi; Chang, Christopher; Xue, Hanrong; Lu, Cheng; Jiang, Miao; Liu, Yan; Xiao, Zuke; Liu, Weiyou; Shang, Yunfei; Chen, Jianjian; Wen, Minyong; Lu, Aiping

    2013-01-01

    Xiaoqinglong granules (XQLG) has been shown to be an effective therapy in asthma animal models. We reviewed the literature and conducted this study to assess the impact of XQLG as an add-on therapy to treatment with fluticasone/salmeterol (seretide) in adult patients with mild-to-moderate, persistent asthma. A total of 178 patients were randomly assigned to receive XQLG and seretide or seretide plus placebo for 90 days. Asthma control was assessed by asthma control test (ACT), symptoms scores, FEV1, and PEF. Baseline patient-reported Chinese medicine (CM)-specific symptoms were analyzed to determine whether the symptoms may be possible indicators of treatment response by conducting latent class analysis (LCA). There was no statistically significant difference in ACT score between two groups. In the subset of 70 patients with symptoms defined by CM criteria, XQLG add-on therapy was found to significantly increase the levels of asthma control according to global initiative for asthma (GINA) guidelines (P = 0.0329). There was no significant difference in another subset of 100 patients with relatively low levels of the above-mentioned symptoms (P = 0.1291). Results of LCA suggest that patients with the six typical symptoms defined in CM may benefit from XQLG. PMID:23431348

  13. Control of Combustion-Instabilities Through Various Passive Devices

    NASA Technical Reports Server (NTRS)

    Frendi, Abdelkader; Nesman, Tom; Canabal, Francisco

    2005-01-01

    Results of a computational study on the effectiveness of various passive devices for the control of combustion instabilities are presented. An axi-symmetric combustion chamber is considered. The passive control devices investigated are, baffles, Helmholtz resonators and quarter-waves. The results show that a Helmholtz resonator with a smooth orifice achieves the best control results, while a baffle is the least effective for the frequency tested. At high sound pressure levels, the Helmholtz resonator is less effective. It is also found that for a quarter wave, the smoothness of the orifice has the opposite effect than the Helmholtz resonator, i.e. results in less control.

  14. DEVICE CONTROL TOOL FOR CEBAF BEAM DIAGNOSTICS SOFTWARE

    SciTech Connect

    Pavel Chevtsov

    2008-02-11

    Continuously monitoring the beam quality in the CEBAF accelerator, a variety of beam diagnostics software created at Jefferson Lab makes a significant contribution to very high availability of the machine for nuclear physics experiments. The interface between this software and beam instrumentation hardware components is provided by a device control tool, which is optimized for beam diagnostics tasks. As a part of the device/driver development framework at Jefferson Lab, this tool is very easy to support and extend to integrate new beam instrumentation components. All device control functions are based on the configuration (ASCII text) files that completely define the used hardware interface standards (CAMAC, VME, RS-232, GPIB, etc.) and communication protocols. The paper presents the main elements of the device control tool for beam diagnostics software at Jefferson Lab.

  15. Flow control concepts for thread-based microfluidic devices

    PubMed Central

    Ballerini, David R.; Li, Xu; Shen, Wei

    2011-01-01

    The emerging concept of thread-based microfluidics has shown great promise for application to inexpensive disease detection and environmental monitoring. To allow the creation of more sophisticated and functional thread-based sensor designs, the ability to better control and understand the flow of fluids in the devices is required. To meet this end, various mechanisms for controlling the flow of reagents and samples in thread-based microfluidic devices are investigated in this study. A study of fluid penetration in single threads and in twined threads provides greater practical understanding of fluid velocity and ultimate penetration for the design of devices. “Switches” which control when or where flow can occur, or allow the mixing of multiple fluids, have been successfully prototyped from multifilament threads, plastic films, and household adhesive. This advancement allows the fabrication of more functional sensory devices which can incorporate more complex detection chemistries, while maintaining low production cost and simplicity of construction. PMID:21483659

  16. Virtual Machine Language Controls Remote Devices

    NASA Technical Reports Server (NTRS)

    2014-01-01

    Kennedy Space Center worked with Blue Sun Enterprises, based in Boulder, Colorado, to enhance the company's virtual machine language (VML) to control the instruments on the Regolith and Environment Science and Oxygen and Lunar Volatiles Extraction mission. Now the NASA-improved VML is available for crewed and uncrewed spacecraft, and has potential applications on remote systems such as weather balloons, unmanned aerial vehicles, and submarines.

  17. Increased inspiratory esophagogastric junction pressure in systemic sclerosis: An add-on to antireflux barrier

    PubMed Central

    Nobre e Souza, Miguel Ângelo; Bezerra, Patrícia Carvalho; Nobre, Rivianny Arrais; Holanda, Esther Studart da Fonseca; dos Santos, Armênio Aguiar

    2015-01-01

    AIM: To investigate crural diaphragm (CD) function in systemic sclerosis (SSc) using high-resolution manometry and standardized inspiratory maneuvers. METHODS: Eight SSc volunteers (average age, 40.1 years; one male) and 13 controls (average age, 32.2 years; six males) participated in the study. A high-resolution manometry/impedance system measured the esophagus and esophagogastric junction (EGJ) pressure profile during swallows and two respiratory maneuvers: sinus arrhythmia maneuver (SAM; the average of six EGJ peak pressures during 5-s deep inhalations) and threshold maneuver (TM; the EGJ peak pressures during forced inhalation under 12 and 24 cmH2O loads). Inspiratory diaphragm lowering (IDL) was taken as the displacement of the EGJ high-pressure zone during the SAM. RESULTS: SSc patients had lower mean lower esophageal sphincter pressure than controls during normal breathing (19.7 ± 2.8 mmHg vs 32.2 ± 2.7 mmHg, P = 0.007). Sinus arrhythmia maneuver pressure was higher in SSc patients than in controls (142.6 ± 9.4 mmHg vs 104.6 ± 13.8 mmHg, P = 0.019). Sinus arrhythmia maneuver pressure normalized to IDL was also higher in SSc patients than in controls (83.8 ± 13.4 mmHg vs 37.5 ± 6.9 mmHg, P = 0.005). Threshold maneuver pressures normalized to IDL were also greater in SSc patients than in controls (TM 12 cmH2O: 85.1 ± 16.4 mmHg vs 43.9 ± 6.3 mmHg, P = 0.039; TM 24 cmH2O: 85.2 ± 16.4 mmHg vs 46.2 ± 6.6 mmHg, P = 0.065). Inspiratory diaphragm lowering in SSc patients was less than in controls (2.1 ± 0.3 cm vs 3 ± 0.2 cm, P = 0.011). CONCLUSION: SSc patients had increased inspiratory EGJ pressure. This is an add-on to EGJ pressure and indicates that the antireflux barrier can be trained. PMID:25717239

  18. Specification of supervisory control systems for ventricular assist devices.

    PubMed

    Cavalheiro, André C M; Santos Fo, Diolino J; Andrade, Aron; Cardoso, José Roberto; Horikawa, Osvaldo; Bock, Eduardo; Fonseca, Jeison

    2011-05-01

    One of the most important recent improvements in cardiology is the use of ventricular assist devices (VADs) to help patients with severe heart diseases, especially when they are indicated to heart transplantation. The Institute Dante Pazzanese of Cardiology has been developing an implantable centrifugal blood pump that will be able to help a sick human heart to keep blood flow and pressure at physiological levels. This device will be used as a totally or partially implantable VAD. Therefore, an improvement on device performance is important for the betterment of the level of interaction with patient's behavior or conditions. But some failures may occur if the device's pumping control does not follow the changes in patient's behavior or conditions. The VAD control system must consider tolerance to faults and have a dynamic adaptation according to patient's cardiovascular system changes, and also must attend to changes in patient conditions, behavior, or comportments. This work proposes an application of the mechatronic approach to this class of devices based on advanced techniques for control, instrumentation, and automation to define a method for developing a hierarchical supervisory control system that is able to perform VAD control dynamically, automatically, and securely. For this methodology, we used concepts based on Bayesian network for patients' diagnoses, Petri nets to generate a VAD control algorithm, and Safety Instrumented Systems to ensure VAD system security. Applying these concepts, a VAD control system is being built for method effectiveness confirmation. PMID:21595713

  19. Remote controlled ISI devices for RPV bottom head

    SciTech Connect

    Shiga, S.; Mori, H.; Kobayashi, K. Sasaki, T.

    1995-08-01

    The bottom head of a reactor pressure vessel (RPV) of the boiling water reactor (BWR) is one of the areas on which it is very difficult to perform an inservice inspection (ISI). Welds in a bottom head central disk and a drain nozzle are required to be inspected, but its accessibility is restricted by a RPV skirt, a thermal insulation, control rod drive housings and incore monitor housings. Therefore, the remote mechanized scanners are necessary to access and examine the welds. Two kinds of new device were developed to accomplish this inspection. The bottom head central disk weld inspection device has a parallel link mechanism scanning arm with a combined-transducer module to get as much as wide scanning area between control rod drive housings. The device is driven along the weld by moving on the separable track which is set temporally on the bottom head insulation. The drain nozzle weld inspection device has a horseshoe shaped gear mechanism to drive a combined-transducer module. The device is set up on to the drain nozzle using an insertion handle. Both devices have an emergency retrieval mechanism to withdraw the devices in case of power loss accident. Those devices were demonstrated by a mock-up test to be applicable to the inspection of the RPV bottom head.

  20. The Physiologic Effects of Multiple Simultaneous Electronic Control Device Discharges

    PubMed Central

    Dawes, Donald M.; Ho, Jeffrey D.; Reardon, Robert F.; Sweeney, James D.; Miner, James R.

    2010-01-01

    Objectives: Law enforcement and military personnel use electronic control devices to control non-compliant and actively resistive subjects. The TASER® Shockwave is a new electronic control device designed specifically as an area denial device capable of delivering multiple simultaneous discharges. This is the first study to examine the effects of multiple simultaneous device discharges in humans. Methods: Volunteers were exposed to multiple (two to three), simultaneous 5-second discharges from the Shockwave device to the chest, back, chest to abdomen, or thighs. Blood was analyzed before and after discharge for pH, lactate, potassium, creatine kinase (CK), and troponin. Continuous spirometry was performed before, during, and after the discharge. In addition, electrocardiograms (ECGs) before and after discharge were recorded, and echocardiography was used to determine the rhythm during discharge. Results: Small elevations of lactate occurred. Moderate increases in CK at 24 hours occurred and appeared to be related to the number of simultaneous discharges. There was a trend to a decrease in minute ventilation in the volunteers exposed to two simultaneous discharges, but it did not reach statistical significance. ECG changes only reflected an increase in vagal tone, and there was no evidence of capture by echocardiography. Five-second, simultaneous, multiple exposures to the TASER Shockwave device were reasonably tolerated by our human volunteers. Conclusion: Our study suggests that this device may have a reasonable risk/benefit ratio when used to protect an area from a threat. PMID:20411076

  1. A proposed protocol for remote control of automated assessment devices

    SciTech Connect

    Kissock, P.S.

    1996-09-01

    Systems and devices that are controlled remotely are becoming more common in security systems in the US Air Force and other government agencies to provide protection of valuable assets. These systems reduce the number of needed personnel while still providing a high level of protection. However, each remotely controlled device usually has its own communication protocol. This limits the ability to change devices without changing the system that provides the communications control to the device. Sandia is pursuing a standard protocol that can be used to communicate with the different devices currently in use, or may be used in the future, in the US Air Force and other government agencies throughout the security community. Devices to be controlled include intelligent pan/tilt mounts, day/night video cameras., thermal imaging cameras, and remote data processors. Important features of this protocol include the ability to send messages of varying length, identify the sender, and more importantly, control remote data processors. As camera and digital signal processor (DSP) use expands, the DSP will begin to reside in the camera itself. The DSP can be used to provide auto-focus, frame-to- frame image registration, video motion detection (VMD), target detection, tracking, image compression, and many other functions. With the serial data control link, the actual DSP software can be updated or changed as required. Coaxial video cables may become obsolete once a compression algorithm is established in the DSP. This paper describes the proposed public domain protocol, features, and examples of use. The authors hope to elicit comments from security technology developers regarding format and use of remotely controlled automated assessment devices. 2 figs., 1 tab.

  2. 24 CFR 990.190 - Other formula expenses (add-ons).

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 4 2012-04-01 2012-04-01 false Other formula expenses (add-ons). 990.190 Section 990.190 Housing and Urban Development REGULATIONS RELATING TO HOUSING AND URBAN DEVELOPMENT (CONTINUED) OFFICE OF ASSISTANT SECRETARY FOR PUBLIC AND INDIAN HOUSING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT THE PUBLIC...

  3. Civic Engagement and Global Citizenship in a University Context: Core Business or Desirable Add-On?

    ERIC Educational Resources Information Center

    Munck, Ronaldo

    2010-01-01

    Can civic engagement become a "core business" of the contemporary university, or is it an attractive "add-on" that is not affordable in the current economic climate? Contemporary universities often play an important role in local community development and, as such, have the opportunity to develop civic engagement strategies to sit alongside…

  4. Voltage controlled spintronic devices for logic applications

    DOEpatents

    You, Chun-Yeol; Bader, Samuel D.

    2001-01-01

    A reprogrammable logic gate comprising first and second voltage-controlled rotation transistors. Each transistor comprises three ferromagnetic layers with a spacer and insulating layer between the first and second ferromagnetic layers and an additional insulating layer between the second and third ferromagnetic layers. The third ferromagnetic layer of each transistor is connected to each other, and a constant external voltage source is applied to the second ferromagnetic layer of the first transistor. As input voltages are applied to the first ferromagnetic layer of each transistor, the relative directions of magnetization of the ferromagnetic layers and the magnitude of the external voltage determines the output voltage of the gate. By altering these parameters, the logic gate is capable of behaving as AND, OR, NAND, or NOR gates.

  5. Implementation of Adaptive Digital Controllers on Programmable Logic Devices

    NASA Technical Reports Server (NTRS)

    Gwaltney, David A.; King, Kenneth D.; Smith, Keary J.; Monenegro, Justino (Technical Monitor)

    2002-01-01

    Much has been made of the capabilities of FPGA's (Field Programmable Gate Arrays) in the hardware implementation of fast digital signal processing. Such capability also makes an FPGA a suitable platform for the digital implementation of closed loop controllers. Other researchers have implemented a variety of closed-loop digital controllers on FPGA's. Some of these controllers include the widely used proportional-integral-derivative (PID) controller, state space controllers, neural network and fuzzy logic based controllers. There are myriad advantages to utilizing an FPGA for discrete-time control functions which include the capability for reconfiguration when SRAM-based FPGA's are employed, fast parallel implementation of multiple control loops and implementations that can meet space level radiation tolerance requirements in a compact form-factor. Generally, a software implementation on a DSP (Digital Signal Processor) or microcontroller is used to implement digital controllers. At Marshall Space Flight Center, the Control Electronics Group has been studying adaptive discrete-time control of motor driven actuator systems using digital signal processor (DSP) devices. While small form factor, commercial DSP devices are now available with event capture, data conversion, pulse width modulated (PWM) outputs and communication peripherals, these devices are not currently available in designs and packages which meet space level radiation requirements. In general, very few DSP devices are produced that are designed to meet any level of radiation tolerance or hardness. The goal of this effort is to create a fully digital, flight ready controller design that utilizes an FPGA for implementation of signal conditioning for control feedback signals, generation of commands to the controlled system, and hardware insertion of adaptive control algorithm approaches. An alternative is required for compact implementation of such functionality to withstand the harsh environment

  6. 3D hybrid wound devices for spatiotemporally controlled release kinetics.

    PubMed

    Ozbolat, Ibrahim T; Koc, Bahattin

    2012-12-01

    This paper presents localized and temporal control of release kinetics over 3-dimensional (3D) hybrid wound devices to improve wound-healing process. Imaging study is performed to extract wound bed geometry in 3D. Non-Uniform Rational B-Splines (NURBS) based surface lofting is applied to generate functionally graded regions. Diffusion-based release kinetics model is developed to predict time-based release of loaded modifiers for functionally graded regions. Multi-chamber single nozzle solid freeform dispensing system is used to fabricate wound devices with controlled dispensing concentration. Spatiotemporal control of biological modifiers thus enables a way to achieve target delivery to improve wound healing. PMID:22672934

  7. Experimental and simulated control of lift using trailing edge devices

    NASA Astrophysics Data System (ADS)

    Cooperman, A.; Blaylock, M.; van Dam, C. P.

    2014-12-01

    Two active aerodynamic load control (AALC) devices coupled with a control algorithm are shown to decrease the change in lift force experienced by an airfoil during a change in freestream velocity. Microtabs are small (1% chord) surfaces deployed perpendicular to an airfoil, while microjets are pneumatic jets with flow perpendicular to the surface of the airfoil near the trailing edge. Both devices are capable of producing a rapid change in an airfoil's lift coefficient. A control algorithm for microtabs has been tested in a wind tunnel using a modified S819 airfoil, and a microjet control algorithm has been simulated for a NACA 0012 airfoil using OVERFLOW. In both cases, the AALC devices have shown the ability to mitigate the changes in lift during a gust.

  8. Microgravity cursor control device evaluation for Space Station Freedom workstations

    NASA Technical Reports Server (NTRS)

    Adam, Susan; Holden, Kritina L.; Gillan, Douglas; Rudisill, Marianne

    1991-01-01

    This research addressed direct manipulation interface (curser-controlled device) usability in microgravity. The data discussed are from KC-135 flights. This included pointing and dragging movements over a variety of angles and distances. Detailed error and completion time data provided researchers with information regarding cursor control shape, selection button arrangement, sensitivity, selection modes, and considerations for future research.

  9. Rehabilitation device with variable resistance and intelligent control.

    PubMed

    Dong, Shufang; Lu, Ke-Qian; Sun, J Q; Rudolph, Katherine

    2005-04-01

    Resistance exercise has been widely reported to have positive rehabilitation effects for patients with neuromuscular and orthopaedic conditions. This paper presents an optimal design of magneto-rheological fluid dampers for variable resistance exercise device in the form of a knee brace. An intelligent supervisory control for regulating the resistive force or torque of the knee brace has also been studied. The device provides both isometric and isokinetic strength training for the knee. PMID:15694609

  10. Rehabilitation device with variable resistance and intelligent control

    PubMed Central

    Dong, Shufang; Lu, Ke-Qian; Sun, J.Q.; Rudolph, Katherine

    2008-01-01

    Resistance exercise has been widely reported to have positive rehabilitation effects for patients with neuromuscular and orthopaedic conditions. This paper presents an optimal design of magneto-rheological fluid dampers for variable resistance exercise device in the form of a knee brace. An intelligent supervisory control for regulating the resistive force or torque of the knee brace has also been studied. The device provides both isometric and isokinetic strength training for the knee. PMID:15694609

  11. Implementation of Adaptive Digital Controllers on Programmable Logic Devices

    NASA Technical Reports Server (NTRS)

    Gwaltney, David A.; King, Kenneth D.; Smith, Keary J.; Ormsby, John (Technical Monitor)

    2002-01-01

    Much has been made of the capabilities of FPGA's (Field Programmable Gate Arrays) in the hardware implementation of fast digital signal processing (DSP) functions. Such capability also makes and FPGA a suitable platform for the digital implementation of closed loop controllers. There are myriad advantages to utilizing an FPGA for discrete-time control functions which include the capability for reconfiguration when SRAM- based FPGA's are employed, fast parallel implementation of multiple control loops and implementations that can meet space level radiation tolerance in a compact form-factor. Other researchers have presented the notion that a second order digital filter with proportional-integral-derivative (PID) control functionality can be implemented in an FPGA. At Marshall Space Flight Center, the Control Electronics Group has been studying adaptive discrete-time control of motor driven actuator systems using digital signal processor (DSF) devices. Our goal is to create a fully digital, flight ready controller design that utilizes an FPGA for implementation of signal conditioning for control feedback signals, generation of commands to the controlled system, and hardware insertion of adaptive control algorithm approaches. While small form factor, commercial DSP devices are now available with event capture, data conversion, pulse width modulated outputs and communication peripherals, these devices are not currently available in designs and packages which meet space level radiation requirements. Meeting our goals requires alternative compact implementation of such functionality to withstand the harsh environment encountered on spacecraft. Radiation tolerant FPGA's are a feasible option for reaching these goals.

  12. 10 CFR 31.5 - Certain detecting, measuring, gauging, or controlling devices and certain devices for producing...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... devices and certain devices for producing light or an ionized atmosphere. 2 31.5 Section 31.5 Energy..., measuring, gauging, or controlling devices and certain devices for producing light or an ionized atmosphere... composition, or for producing light or an ionized atmosphere. (b)(1) The general license in paragraph (a)...

  13. 10 CFR 31.5 - Certain detecting, measuring, gauging, or controlling devices and certain devices for producing...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... devices and certain devices for producing light or an ionized atmosphere. 2 31.5 Section 31.5 Energy..., measuring, gauging, or controlling devices and certain devices for producing light or an ionized atmosphere... composition, or for producing light or an ionized atmosphere. (b)(1) The general license in paragraph (a)...

  14. 10 CFR 31.5 - Certain detecting, measuring, gauging, or controlling devices and certain devices for producing...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... devices and certain devices for producing light or an ionized atmosphere. 2 31.5 Section 31.5 Energy..., measuring, gauging, or controlling devices and certain devices for producing light or an ionized atmosphere... composition, or for producing light or an ionized atmosphere. (b)(1) The general license in paragraph (a)...

  15. 10 CFR 31.5 - Certain detecting, measuring, gauging, or controlling devices and certain devices for producing...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... devices and certain devices for producing light or an ionized atmosphere. 2 31.5 Section 31.5 Energy..., measuring, gauging, or controlling devices and certain devices for producing light or an ionized atmosphere... composition, or for producing light or an ionized atmosphere. (b)(1) The general license in paragraph (a)...

  16. 10 CFR 31.5 - Certain detecting, measuring, gauging, or controlling devices and certain devices for producing...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... devices and certain devices for producing light or an ionized atmosphere. 2 31.5 Section 31.5 Energy..., measuring, gauging, or controlling devices and certain devices for producing light or an ionized atmosphere... composition, or for producing light or an ionized atmosphere. (b)(1) The general license in paragraph (a)...

  17. EXOS research on master controllers for robotic devices

    NASA Technical Reports Server (NTRS)

    Marcus, Beth A.; An, Ben; Eberman, Brian

    1992-01-01

    Two projects are currently being conducted by EXOS under the Small Business Innovation Research (SBIR) program with NASA. One project will develop a force feedback device for controlling robot hands, the other will develop an elbow and shoulder exoskeleton which can be integrated with other EXOS devices to provide whole robot arm and hand control. Aspects covered are the project objectives, important research issues which have arisen during the developments, and interim results of the projects. The Phase 1 projects currently underway will result in hardware prototypes and identification of research issues required for complete system development and/or integration.

  18. A controlled biochemical release device with embedded nanofluidic channels

    NASA Astrophysics Data System (ADS)

    Yang, Haifeng; Hong, Wei; Dong, Liang

    2012-04-01

    A controlled release device is developed by embedding nanofluidic biomolecule reservoirs into a polymer network of a stimuli-responsive hydrogel. The reservoirs are made of liquid core-polymer shell nanofibers using co-electrospinning. The mechanism of controlled release is based on buckling instability of the polymer shell under combined axial and radial compression, caused by volume changes of hydrogel responding to a specific stimulus. The device decouples releasable biomolecules from a hydrogel polymer matrix, avoiding chemical interactions between biomolecules and hydrogel polymer chains, and thus, alleviating nontrivial chemical and biological engineering design of hydrogel formulations. Temperature-sensitive hydrogel is used as a model hydrogel.

  19. Medical devices; gastroenterology-urology devices; classification of the vibrator for climax control of premature ejaculation. Final order.

    PubMed

    2015-05-28

    The Food and Drug Administration (FDA) is classifying the vibrator for climax control of premature ejaculation into class II (special controls). The special controls that will apply to the device are identified in this order and will be part of the codified language for the classification of the vibrator for climax control of premature ejaculation. The Agency is classifying the device into class II (special controls) in order to provide a reasonable assurance of safety and effectiveness of the device. PMID:26030939

  20. Medical devices; immunology and microbiology devices; classification of quality control material for cystic fibrosis nucleic acid assays. Final rule.

    PubMed

    2007-01-10

    The Food and Drug Administration (FDA) is classifying quality control material for cystic fibrosis nucleic acid assays into class II (special controls). The special control that will apply to the device is the guidance document entitled "Class II Special Controls Guidance Document: Quality Control Material for Cystic Fibrosis Nucleic Acid Assays." The agency is classifying the device into class II (special controls) in order to provide a reasonable assurance of safety and effectiveness of the device. Elsewhere in this issue of the Federal Register, FDA is announcing the availability of the guidance document that will serve as the special control for this device. PMID:17294552

  1. Add on testosterone therapy in negative symptoms of schizophrenia with gonadal trauma: Hitting the bull's eye.

    PubMed

    Jha, Shailesh; Garg, Amit

    2016-06-30

    The coincidence or causal incidence of hormonal dysregulation leading to psychotic manifestation had been a point of debate. The interplay of these hormones in pathogenesis of psychotic symptom domains is still inconclusive along with some symptom domains which worsen with antipsychotics. Early detection and treatment with liaison approach is of great help to such patients. We report a case of schizophrenia with primary hypogonadism that responded dramatically to add on testosterone supplement. PMID:27138816

  2. Methods of Measurement for Semiconductor Materials, Process Control, and Devices

    NASA Technical Reports Server (NTRS)

    Bullis, W. M. (Editor)

    1973-01-01

    The development of methods of measurement for semiconductor materials, process control, and devices is reported. Significant accomplishments include: (1) Completion of an initial identification of the more important problems in process control for integrated circuit fabrication and assembly; (2) preparations for making silicon bulk resistivity wafer standards available to the industry; and (3) establishment of the relationship between carrier mobility and impurity density in silicon. Work is continuing on measurement of resistivity of semiconductor crystals; characterization of generation-recombination-trapping centers, including gold, in silicon; evaluation of wire bonds and die attachment; study of scanning electron microscopy for wafer inspection and test; measurement of thermal properties of semiconductor devices; determination of S-parameters and delay time in junction devices; and characterization of noise and conversion loss of microwave detector diodes.

  3. Control system devices : architectures and supply channels overview.

    SciTech Connect

    Trent, Jason; Atkins, William Dee; Schwartz, Moses Daniel; Mulder, John C.

    2010-08-01

    This report describes a research project to examine the hardware used in automated control systems like those that control the electric grid. This report provides an overview of the vendors, architectures, and supply channels for a number of control system devices. The research itself represents an attempt to probe more deeply into the area of programmable logic controllers (PLCs) - the specialized digital computers that control individual processes within supervisory control and data acquisition (SCADA) systems. The report (1) provides an overview of control system networks and PLC architecture, (2) furnishes profiles for the top eight vendors in the PLC industry, (3) discusses the communications protocols used in different industries, and (4) analyzes the hardware used in several PLC devices. As part of the project, several PLCs were disassembled to identify constituent components. That information will direct the next step of the research, which will greatly increase our understanding of PLC security in both the hardware and software areas. Such an understanding is vital for discerning the potential national security impact of security flaws in these devices, as well as for developing proactive countermeasures.

  4. 49 CFR 236.601 - Signals controlled by devices; location.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Signals controlled by devices; location. 236.601 Section 236.601 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RULES, STANDARDS, AND INSTRUCTIONS GOVERNING THE INSTALLATION, INSPECTION, MAINTENANCE, AND REPAIR...

  5. 49 CFR 178.338-11 - Discharge control devices.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... vehicle over 3,500 gallons water capacity, remote means of automatic closure must be installed at the ends... thermal device must be installed so that heat from a fire in the loading/unloading connection area will activate the emergency control system. (ii) On a cargo tank motor vehicle of 3,500 gallons water...

  6. 49 CFR 178.338-11 - Discharge control devices.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Discharge control devices. 178.338-11 Section 178.338-11 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR PACKAGINGS Specifications for Containers for...

  7. Biopolymers in controlled release devices for agricultural applications.

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The use of biopolymers such as starch for agricultural applications including controlled release devices is growing due the environmental benefits. Recently, concerns have grown about the worldwide spread of parasitic mites (Varroa destructor) that infect colonies of honey bees (Apis mellifera L.). ...

  8. Automatic coolant flow control device for a nuclear reactor assembly

    DOEpatents

    Hutter, E.

    1984-01-27

    A device which controls coolant flow through a nuclear reactor assembly comprises a baffle means at the exit end of said assembly having a plurality of orifices, and a bimetallic member in operative relation to the baffle means such that at increased temperatures said bimetallic member deforms to unblock some of said orifices and allow increased coolant flow therethrough.

  9. Active control of excessive sound emission on a mobile device.

    PubMed

    Jeon, Se-Woon; Youn, Dae Hee; Park, Young-cheol; Lee, Gun-Woo

    2015-04-01

    During a phone conversation, loud vocal emission from the far-end to the near-end space can disturb nearby people. In this paper, the possibility of actively controlling such unwanted sound emission using a control source placed on the mobile device is investigated. Two different approaches are tested: Global control, minimizing the potential energy measured along a volumetric space surface, and local control, minimizing the squared sound pressure at a discrete point on the phone. From the test results, both approaches can reduce the unwanted sound emission by more than 6 dB in the frequency range up to 2 kHz. PMID:25920885

  10. Determining Desirable Cursor Control Device Characteristics for NASA Exploration Missions

    NASA Technical Reports Server (NTRS)

    Sandor, Aniko; Holden, Kritina

    2007-01-01

    The Crew Exploration Vehicle (CEV) that will travel to the moon and Mars, and all future Exploration vehicles and habitats will be highly computerized, necessitating an accurate method of interaction with the computers. The design of a cursor control device will have to take into consideration g-forces, vibration, gloved operations, and the specific types of tasks to be performed. The study described here is being undertaken to begin identifying characteristics of cursor control devices that will work well for the unique Exploration mission environments. The objective of the study is not to identify a particular device, but to begin identifying design characteristics that are usable and desirable for space missions. Most cursor control devices have strengths and weaknesses; they are more appropriate for some tasks and less suitable for others. The purpose of this study is to collect some initial usability data on a large number of commercially available and proprietary cursor control devices. A software test battery was developed for this purpose. Once data has been collected using these low-level, basic point/click/drag tasks, higher fidelity, scenario-driven evaluations will be conducted with a reduced set of devices. The standard tasks used for testing cursor control devices are based on a model of human movement known as Fitts law. Fitts law predicts that the time to acquire a target is logarithmically related to the distance over the target size. To gather data for analysis with this law, fundamental, low-level tasks are used such as dragging or pointing at various targets of different sizes from various distances. The first four core tasks for the study were based on the ISO 9241-9:(2000) document from the International Organization for Standardization that contains the requirements for non-keyboard input devices. These include two pointing tasks, one dragging and one tracking task. The fifth task from ISO 9241-9, the circular tracking task was not used

  11. Micropatterned photoalignment for wavefront controlled switchable optical devices

    NASA Astrophysics Data System (ADS)

    Glazar, Nikolaus

    Photoalignment is a well-established technique for surface alignment of the liquid crystal director. Previously, chrome masks were necessary for patterned photoalignment but were difficult to use, costly, and inflexible. To extend the capabilities of photoalignment we built an automated maskless multi-domain photoalignment device based on a DMD (digital multimirror device) projection system. The device is capable of creating arbitrary photoalignment patterns with micron-sized features. Pancharatnam-Berry phase (PB-phase) is a geometric phase that arises from cyclic change of polarization state. By varying the azimuthal anchoring angle in a hybrid-aligned liquid crystal cell we can control the spatial variation of the PB-phase shift. Using our automated photoalignment device to align the liquid crystal arbitrary wave front manipulations are possible. The PB-phase shift effect is maximized when the cell is tuned to have a half-wave retardation and disappears at full-wave retardation, so the cell can be switched on and off by applying a voltage. Two wavefront controlled devices developed using this technique will be discussed: A switchable liquid crystal phase shift mask for creating sub-diffraction sized photolithographic features, and a transparent diffractive display that utilizes a switchable liquid crystal diffraction grating.

  12. Device Cleaning and Infection Control in Aerosol Therapy.

    PubMed

    O'Malley, Catherine A

    2015-06-01

    Aerosol delivery equipment used to administer inhaled medications includes the nebulizer, positive expiratory pressure devices added to the nebulizer, and valved holding chambers (spacers). These devices are semi-critical medical devices, and as such, infection prevention and control (IPC) guidelines recommend that they be cleaned, disinfected, rinsed with sterile water, and air-dried. There is confusion surrounding the care of aerosol devices because of inconsistencies in the various published IPC guidelines, lack of a standard of practice among institutions and respiratory therapists (RTs), and manufacturer's instructions for use of these devices are not always compatible with guidelines or practice. Challenges lie in awareness of IPC guidelines and establishing a standard for the care of aerosol delivery devices among all stakeholders/manufacturers, governments, vendors, and users. The latest IPC guideline from the Cystic Fibrosis Foundation, reviewed and endorsed by the Society for Healthcare Epidemiology of America and the Association for Professionals in Infection Control, has a recommendation for disposable nebulizers and a recommendation for reusable nebulizers. Reusable nebulizers should be cleaned, disinfected, rinsed with sterile water (if using a cold disinfectant), and air-dried between uses. The mouthpiece/mask of disposable nebulizers should be wiped with an alcohol pad, the residual volume should be rinsed out with sterile water after use, and the nebulizer should be replaced every 24 h. The RT plays a significant and responsible role in providing and teaching aerosol therapy to patients. The RT and all stakeholders need to work together to provide a standard of care for the safe use of aerosol delivery devices. PMID:26070583

  13. Solid state carbon nanotube device for controllable trion electroluminescence emission

    NASA Astrophysics Data System (ADS)

    Liang, Shuang; Ma, Ze; Wei, Nan; Liu, Huaping; Wang, Sheng; Peng, Lian-Mao

    2016-03-01

    Semiconducting carbon nanotubes (CNTs) have a direct chirality-dependent bandgap and reduced dimensionality-related quantum confinement effects, which are closely related to the performance of optoelectronic devices. Here, taking advantage of the large energy separations between neutral singlet excitons and charged excitons, i.e. trions in CNTs, we have achieved for the first time all trion electroluminescence (EL) emission from chirality-sorted (8,3) and (8,4) CNT-based solid state devices. We showed that strong trion emission can be obtained as a result of localized impact excitation and electrically injected holes, with an estimated efficiency of ~5 × 10-4 photons per injected hole. The importance of contact-controlled carrier injection (including symmetric and asymmetric contact configurations) and EL spectral stability for gradually increasing bias were also investigated. The realization of electrically induced pure trion emission opens up a new opportunity for CNT film-based optoelectronic devices, providing a new degree of freedom in controlling the devices to extend potential applications in spin or magnetic optoelectronics fields.Semiconducting carbon nanotubes (CNTs) have a direct chirality-dependent bandgap and reduced dimensionality-related quantum confinement effects, which are closely related to the performance of optoelectronic devices. Here, taking advantage of the large energy separations between neutral singlet excitons and charged excitons, i.e. trions in CNTs, we have achieved for the first time all trion electroluminescence (EL) emission from chirality-sorted (8,3) and (8,4) CNT-based solid state devices. We showed that strong trion emission can be obtained as a result of localized impact excitation and electrically injected holes, with an estimated efficiency of ~5 × 10-4 photons per injected hole. The importance of contact-controlled carrier injection (including symmetric and asymmetric contact configurations) and EL spectral stability for

  14. Growth control of sessile microbubbles in PDMS devices.

    PubMed

    Volk, Andreas; Rossi, Massimiliano; Kähler, Christian J; Hilgenfeldt, Sascha; Marin, Alvaro

    2015-12-21

    In a microfluidic environment, the presence of bubbles is often detrimental to the functionality of the device, leading to clogging or cavitation, but microbubbles can also be an indispensable asset in other applications such as microstreaming. In either case, it is crucial to understand and control the growth or shrinkage of these bodies of air, in particular in common soft-lithography devices based on polydimethylsiloxane (PDMS), which is highly permeable to gases. In this work, we study the gas transport into and out of a bubble positioned in a microfluidic device, taking into account the direct gas exchange through PDMS as well as the transport of gas through the liquid in the device. Hydrostatic pressure regulation allows for the quantitative control of growth, shrinkage, or the attainment of a stable equilibrium bubble size. We find that the vapor pressure of the liquid plays an important role for the balance of gas transport, accounting for variability in experimental conditions and suggesting additional means of bubble size control in applications. PMID:26517506

  15. Computer controlled fluorometer device and method of operating same

    DOEpatents

    Kolber, Z.; Falkowski, P.

    1990-07-17

    A computer controlled fluorometer device and method of operating same, said device being made to include a pump flash source and a probe flash source and one or more sample chambers in combination with a light condenser lens system and associated filters and reflectors and collimators, as well as signal conditioning and monitoring means and a programmable computer means and a software programmable source of background irradiance that is operable according to the method of the invention to rapidly, efficiently and accurately measure photosynthetic activity by precisely monitoring and recording changes in fluorescence yield produced by a controlled series of predetermined cycles of probe and pump flashes from the respective probe and pump sources that are controlled by the computer means. 13 figs.

  16. Computer controlled fluorometer device and method of operating same

    DOEpatents

    Kolber, Zbigniew; Falkowski, Paul

    1990-01-01

    A computer controlled fluorometer device and method of operating same, said device being made to include a pump flash source and a probe flash source and one or more sample chambers in combination with a light condenser lens system and associated filters and reflectors and collimators, as well as signal conditioning and monitoring means and a programmable computer means and a software programmable source of background irradiance that is operable according to the method of the invention to rapidly, efficiently and accurately measure photosynthetic activity by precisely monitoring and recording changes in fluorescence yield produced by a controlled series of predetermined cycles of probe and pump flashes from the respective probe and pump sources that are controlled by the computer means.

  17. Mobile monolithic polymer elements for flow control in microfluidic devices

    DOEpatents

    Hasselbrink, Jr., Ernest F.; Rehm, Jason E.; Shepodd, Timothy J.

    2004-08-31

    A cast-in-place and lithographically shaped mobile, monolithic polymer element for fluid flow control in microfluidic devices and method of manufacture. Microfluid flow control devices, or microvalves that provide for control of fluid or ionic current flow can be made incorporating a cast-in-place, mobile monolithic polymer element, disposed within a microchannel, and driven by either fluid or gas pressure against a retaining or sealing surface. The polymer elements are made by the application of lithographic methods to monomer mixtures formulated in such a way that the polymer will not bond to microchannel walls. The polymer elements can seal against pressures greater than 5000 psi, and have a response time on the order of milliseconds. By the use of energetic radiation it is possible to depolymerize selected regions of the polymer element to form shapes that cannot be produced by conventional lithographic patterning and would be impossible to machine.

  18. Mobile monolithic polymer elements for flow control in microfluidic devices

    DOEpatents

    Hasselbrink, Jr., Ernest F.; Rehm, Jason E.; Shepodd, Timothy J.; Kirby, Brian J.

    2005-11-11

    A cast-in-place and lithographically shaped mobile, monolithic polymer element for fluid flow control in microfluidic devices and method of manufacture. Microfluid flow control devices, or microvalves that provide for control of fluid or ionic current flow can be made incorporating a cast-in-place, mobile monolithic polymer element, disposed within a microchannel, and driven by fluid pressure (either liquid or gas) against a retaining or sealing surface. The polymer elements are made by the application of lithographic methods to monomer mixtures formulated in such a way that the polymer will not bond to microchannel walls. The polymer elements can seal against pressures greater than 5000 psi, and have a response time on the order of milliseconds. By the use of energetic radiation it is possible to depolymerize selected regions of the polymer element to form shapes that cannot be produced by conventional lithographic patterning and would be impossible to machine.

  19. Efficacy of Add-on Montelukast in Nonasthmatic Eosinophilic Bronchitis: The Additive Effect on Airway Inflammation, Cough and Life Quality

    PubMed Central

    Bao, Wuping; Liu, Ping; Qiu, Zhongmin; Yu, Li; Hang, Jingqing; Gao, Xiaohua; Zhou, Xin

    2015-01-01

    Background: The efficacy of montelukast (MONT), a cysteinyl leukotriene receptor antagonist, in nonasthmatic eosinophilic bronchitis (NAEB), especially its influence on cough associated life quality is still indefinite. We evaluated the efficacy of MONT combined with budesonide (BUD) as compared to BUD monotherapy in improving life quality, suppressing airway eosinophilia and cough remission in NAEB. Methods: A prospective, open-labeled, multicenter, randomized controlled trial was conducted. Patients with NAEB (aged 18-75 years) were randomized to inhaled BUD (200 μg, bid) or BUD plus oral MONT (10 μg, qn) for 4 weeks. Leicester cough questionnaire (LCQ) life quality scores, cough visual analog scale (CVAS) scores, eosinophil differential ratio (Eos), and eosinophil cationic protein (ECP) in induced sputum were monitored and compared. Results: The control and MONT groups contained 33 and 32 patients, respectively, with similar baseline characteristics. Significant with-in group improvement in CVAS, LCQ scores, Eos, and ECP was observed in both groups during treatment. After 2-week treatment, add-on treatment of MONT was significantly more effective than BUD monotherapy for CVAS decrease and LCQ scores improvement (both P < 0.05). Similar results were seen at 4-week assessment (both P < 0.05). 4-week add-on therapy of MONT also resulted in a higher percentage of patients with normal sputum Eos (<2.5%) and greater decrease of ECP (both P < 0.05). Conclusions: MONT combined with BUD was demonstrated cooperative effects in improvement of life quality, suppression of eosinophilic inflammation, and cough remission in patients with NAEB. PMID:25563311

  20. Control system for insertion devices at the advanced photon source

    SciTech Connect

    Makarov, Oleg A.; Den Hartog, Patric; Moog, Elizabeth R.; Smith, Martin L.

    1997-07-01

    Eighteen insertion devices (IDs) are installed at the Advanced Photon Source (APS), and three more are scheduled for installation by the end of this year. A distributed control system for insertion devices at the APS storage ring was created with the Experimental Physics and Industrial Control System (EPICS). The basic components of this system are operator interfaces (OPIs), input output controllers (IOCs), and a local area network that allows the OPI and IOC to communicate. The IOC operates under the VxWorks OS with an EPICS database and a sequencer. The sequencer runs an ID control program written in State Notation Language. The OPI is built with the EPICS tool MEDM and provides display screens with input and output fields and buttons for gap control of the IDs. Global commands like 'open all IDs' are C-shell scripts invoked from the display menu. The algorithms for control and protection of the ID and ID vacuum chamber and the accuracy of gap control are discussed.

  1. Control system for insertion devices at the Advanced Photon Source

    SciTech Connect

    Makarov, O.A.; Den Hartog, P.; Moog, E.R.; Smith, M.L.

    1997-09-01

    Eighteen insertion devices (IDs) are installed at the Advanced Photon Source (APS), and three more are scheduled for installation by the end of this year. A distributed control system for insertion devices at the APS storage ring was created with the Experimental Physics and Industrial Control System (EPICS). The basic components of this system are operator interfaces (OPIs), input output controllers (IOCs), and a local area network that allows the OPI and IOC to communicate. The IOC operates under the VxWorks OS with an EPICS database and a sequencer. The sequencer runs an ID control program written in State Notation Language. The OPI is built with the EPICS tool MEDM and provides display screens with input and output fields and buttons for gap control of the IDs. Global commands like ``open all IDs`` are C-shell scripts invoked from the display menu. The algorithms for control and protection of the ID and ID vacuum chamber and the accuracy of gap control are discussed.

  2. Control system for insertion devices at the advanced photon source

    SciTech Connect

    Makarov, O.A.; Den Hartog, P.; Moog, E.R.; Smith, M.L.

    1997-07-01

    Eighteen insertion devices (IDs) are installed at the Advanced Photon Source (APS), and three more are scheduled for installation by the end of this year. A distributed control system for insertion devices at the APS storage ring was created with the Experimental Physics and Industrial Control System (EPICS). The basic components of this system are operator interfaces (OPIs), input output controllers (IOCs), and a local area network that allows the OPI and IOC to communicate. The IOC operates under the VxWorks OS with an EPICS database and a sequencer. The sequencer runs an ID control program written in State Notation Language. The OPI is built with the EPICS tool MEDM and provides display screens with input and output fields and buttons for gap control of the IDs. Global commands like {open_quotes}open all IDs{close_quotes} are C-shell scripts invoked from the display menu. The algorithms for control and protection of the ID and ID vacuum chamber and the accuracy of gap control are discussed. {copyright} {ital 1997 American Institute of Physics.}

  3. Solid state carbon nanotube device for controllable trion electroluminescence emission.

    PubMed

    Liang, Shuang; Ma, Ze; Wei, Nan; Liu, Huaping; Wang, Sheng; Peng, Lian-Mao

    2016-03-28

    Semiconducting carbon nanotubes (CNTs) have a direct chirality-dependent bandgap and reduced dimensionality-related quantum confinement effects, which are closely related to the performance of optoelectronic devices. Here, taking advantage of the large energy separations between neutral singlet excitons and charged excitons, i.e. trions in CNTs, we have achieved for the first time all trion electroluminescence (EL) emission from chirality-sorted (8,3) and (8,4) CNT-based solid state devices. We showed that strong trion emission can be obtained as a result of localized impact excitation and electrically injected holes, with an estimated efficiency of ∼5 × 10(-4) photons per injected hole. The importance of contact-controlled carrier injection (including symmetric and asymmetric contact configurations) and EL spectral stability for gradually increasing bias were also investigated. The realization of electrically induced pure trion emission opens up a new opportunity for CNT film-based optoelectronic devices, providing a new degree of freedom in controlling the devices to extend potential applications in spin or magnetic optoelectronics fields. PMID:26953676

  4. Characterization of an add-on multileaf collimator for electron beam therapy

    NASA Astrophysics Data System (ADS)

    Gauer, T.; Sokoll, J.; Cremers, F.; Harmansa, R.; Luzzara, M.; Schmidt, R.

    2008-02-01

    An add-on multileaf collimator for electrons (eMLC) has been developed that provides computer-controlled beam collimation and isocentric dose delivery. The design parameters result from the design study by Gauer et al (2006 Phys. Med. Biol. 51 5987-6003) and were configured such that a compact and light-weight eMLC with motorized leaves can be industrially manufactured and stably mounted on a conventional linear accelerator. In the present study, the efficiency of an initial computer-controlled prototype was examined according to the design goals and the performance of energy- and intensity-modulated treatment techniques. This study concentrates on the attachment and gantry stability as well as the dosimetric characteristics of central-axis and off-axis dose, field size dependence, collimator scatter, field abutment, radiation leakage and the setting of the accelerator jaws. To provide isocentric irradiation, the eMLC can be placed either 16 or 28 cm above the isocentre through interchangeable holders. The mechanical implementation of this feature results in a maximum field displacement of less than 0.6 mm at 90° and 270° gantry angles. Compared to a 10 × 10 cm applicator at 6-14 MeV, the beam penumbra of the eMLC at a 16 cm collimator-to-isocentre distance is 0.8-0.4 cm greater and the depth-dose curves show a larger build-up effect. Due to the loss in energy dependence of the therapeutic range and the much lower dose output at small beam sizes, a minimum beam size of 3 × 3 cm is necessary to avoid suboptimal dose delivery. Dose output and beam symmetry are not affected by collimator scatter when the central axis is blocked. As a consequence of the broader beam penumbra, uniform dose distributions were measured in the junction region of adjacent beams at perpendicular and oblique beam incidence. However, adjacent beams with a high difference in a beam energy of 6 to 14 MeV generate cold and hot spots of approximately 15% in the abutting region. In order to

  5. Sensitivity analysis of the add-on price estimate for the silicon web growth process

    NASA Technical Reports Server (NTRS)

    Mokashi, A. R.

    1981-01-01

    The web growth process, a silicon-sheet technology option, developed for the flat plate solar array (FSA) project, was examined. Base case data for the technical and cost parameters for the technical and commercial readiness phase of the FSA project are projected. The process add on price, using the base case data for cost parameters such as equipment, space, direct labor, materials and utilities, and the production parameters such as growth rate and run length, using a computer program developed specifically to do the sensitivity analysis with improved price estimation are analyzed. Silicon price, sheet thickness and cell efficiency are also discussed.

  6. Method and device for controlling plume during laser welding

    SciTech Connect

    Fuerschbach, P.W.; Jellison, J.L.; Keicher, D.M.; Oberkampf, W.L.

    1989-08-25

    A method and apparatus for enhancing the weldment of a laser welding system is provided. The laser weld plume control device is provided as a cylindrical body defining an upside-down cone cavity, the upper surface of the body circumscribing the base of the cone cavity, the vertex of the cavity forming an orifice which converts the flow of gas, directed through inlets in the upper surface of the body through channels in the wall of the body, from radial flow to an axisymmetric gas jet perpendicular to the surface of the weldment in a direction opposite to the direction of the laser beam. The orifice of the control device is concentrically located with respect to the laser beam and the plume which forms as a result of the welding operation. 6 figs.

  7. Fluoropolymer surface coatings to control droplets in microfluidic devices.

    PubMed

    Riche, Carson T; Zhang, Chuchu; Gupta, Malancha; Malmstadt, Noah

    2014-06-01

    We have demonstrated the application of low surface energy fluoropolymer coatings onto poly(dimethylsiloxane) (PDMS) microfluidic devices for droplet formation and extraction-induced merger of droplets. Initiated chemical vapor deposition (iCVD) was used to pattern fluoropolymer coatings within microchannels based on geometrical constraints. In a two-phase flow system, the range of accessible flow rates for droplet formation was greatly enhanced in the coated devices. The ability to controllably apply the coating only at the inlet facilitated a method for merging droplets. An organic spacer droplet was extracted from between a pair of aqueous droplets. The size of the organic droplet and the flow rate controlled the time to merge the aqueous droplets; the process of merging was independent of the droplet sizes. Extraction-induced droplet merging is a robust method for manipulating droplets that could be applied in translating multi-step reactions to microfluidic platforms. PMID:24722827

  8. Measuring devices for precision manufacturing and quality control

    NASA Astrophysics Data System (ADS)

    Wilhelm, J.; Jacoby, H. D.; Preuss, H. J.

    1980-12-01

    Various miniaturized and low cost transducers were developed for different applications in metrology, precision manufacturing and fabrication control. They comprise: (1) photoelectric linear transducer with micron step pression; (2) incremental and coded transducers; (3) concave mirror x-y transducer; (4) correlation systems for linear and speed measurements; (5) high resolution angle transducers; and (6) correlation optical sensor for distance measurement. Operation principles are explained and several applications are illustrated. Some of the devices are already available.

  9. Emission control devices, fuel additive, and fuel composition changes.

    PubMed Central

    Piver, W T

    1977-01-01

    Emission control devices are installed to meet the exhaust standards of the Clean Air Act for carbon monoxide and hydrocarbons, and it is necessary to know, from a public health point of view, how exhaust emissions may be affected by changes in fuel additives and fuel composition. Since these topics are concerned with developing technologies, the available literature on exhaust emission characteristics and the limited information on health effects, is reviewed. PMID:71235

  10. Emission control devices, fuel additive, and fuel composition changes.

    PubMed

    Piver, W T

    1977-08-01

    Emission control devices are installed to meet the exhaust standards of the Clean Air Act for carbon monoxide and hydrocarbons, and it is necessary to know, from a public health point of view, how exhaust emissions may be affected by changes in fuel additives and fuel composition. Since these topics are concerned with developing technologies, the available literature on exhaust emission characteristics and the limited information on health effects, is reviewed. PMID:71235

  11. Annular Momentum Control Device (AMCD). Volume 1: Laboratory model development

    NASA Technical Reports Server (NTRS)

    1975-01-01

    The annular momentum control device (AMCD) a thin hoop-like wheel with neither shaft nor spokes is described. The wheel floats in a magnetic field and can be rotated by a segmented motor. Potential advantages of such a wheel are low weight, configuration flexibility, a wheel that stiffens with increased speed, vibration isolation, and increased reliability. The analysis, design, fabrication, and testing is described of the laboratory model of the AMCD.

  12. 40 CFR 63.2268 - Initial compliance demonstration for a wet control device.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... control device is contained or destroyed to minimize re-release to the atmosphere such that the desired... wet control device. 63.2268 Section 63.2268 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... device. If you use a wet control device as the sole means of reducing HAP emissions, you must develop...

  13. 40 CFR 63.2268 - Initial compliance demonstration for a wet control device.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... control device is contained or destroyed to minimize re-release to the atmosphere such that the desired... wet control device. 63.2268 Section 63.2268 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... device. If you use a wet control device as the sole means of reducing HAP emissions, you must develop...

  14. 40 CFR 63.2268 - Initial compliance demonstration for a wet control device.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... control device is contained or destroyed to minimize re-release to the atmosphere such that the desired... wet control device. 63.2268 Section 63.2268 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... device. If you use a wet control device as the sole means of reducing HAP emissions, you must develop...

  15. Parametric analysis of a passive cyclic control device for helicopters

    NASA Technical Reports Server (NTRS)

    Kumagai, H.

    1984-01-01

    A parametric study of a passive device which provides a cyclic longitudinal control moment for a helicopter rotor was performed. It utilizes a rotor blade tip which is structurally decoupled from the blade inboard section. This rotor configuration is generally called the Free-Tip Rotor. A two dimensional numerical model was used to review the Constant Lift Tip Rotor, a predecessor of the current configuration, and then the same model was applied to the Passive Cyclic Control Device. The Constant Lift Tip was proven to have the ability to suppress the vibratory lift loading on the tip around the azimuth and to eliminate a significant negative lift peak on the advancing tip. The Passive Cyclic Control Device showed a once-per-revolution lift oscillation with a large amplitude, while minimizing the higher harmonic terms of the lift oscillation. This once-per-revolution oscillation results in the cyclic moment to trim the rotor longitudinally. A rotor performance analysis was performed by a three dimensional numerical model. It indicated that the vortices shed from the junction between the tip and the inboard section has a strong influence on the tip, and it may severely limit the tip performance. It was also shown that the Free-Tip allows the inboard section to have a larger twist, which results in a better performance.

  16. Laboratory study of efficient add-on treatments for interior noise control in light aircraft

    NASA Technical Reports Server (NTRS)

    Mixson, J. S.; Roussos, L. A.; Barton, C. K.; Vaicaitist, R.; Slazak, M.

    1981-01-01

    Experimental and theoretical studies of the transmission loss (TL) of 1.15 x 1.46 m flat stiffened-skin aluminum panels are described. Panel configurations included panels with no treatment and eight combinations of treatments consisting of a fiberglass-septum layer, a foam-foil damping material, and a plywood double wall trim panel. Measured TL of the untreated panel and the panel with a damping layer showed characteristics of the double mass law: at low frequencies the TL followed a mass law trend associated with the average mass of both skin and stiffness, while at higher frequencies the TL followed a mass law trend associated with skin mass only. A comparison of TL for panels treated with a damping layer, a fiberglass layer, or a trim panel showed that the effects of damping are frequency dependent with some performing better below 500 Hz and others performing better above 500 Hz. Treatment combinations showed that two treatments with the same mass could have TL values different by about 10 dB, while other combinations having weights different by a factor of two could have TL values within a few dB over most of the frequency range. The highest TL values (50 dB at 1000 Hz) were obtained with a treatment consisting of a fiberglass layer, a trim panel, and damping layers on both the stiffened panel and the trim panel.

  17. 40 CFR Table 1b to Subpart Dddd of... - Add-on Control Systems Compliance Options

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... dryer zones one and two (at new affected sources) (1) Reduce emissions of total HAP, measured as THC (as carbon) a, by 90 percent; or(2) Limit emissions of total HAP, measured as THC (as carbon) a, to 20 ppmvd... are greater than or equal to 10 ppmvd. a You may choose to subtract methane from THC as...

  18. 40 CFR Table 1b to Subpart Dddd of... - Add-on Control Systems Compliance Options

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... dryer zones one and two (at new affected sources) (1) Reduce emissions of total HAP, measured as THC (as carbon) a, by 90 percent; or(2) Limit emissions of total HAP, measured as THC (as carbon) a, to 20 ppmvd... are greater than or equal to 10 ppmvd. a You may choose to subtract methane from THC as...

  19. A device for automatic photoelectric control of the analytical gap for emission spectrographs

    USGS Publications Warehouse

    Dietrich, John A.; Cooley, Elmo F.; Curry, Kenneth J.

    1977-01-01

    A photoelectric device has been built that automatically controls the analytical gap between electrodes during excitation period. The control device allows for precise control of the analytical gap during the arcing process of samples, resulting in better precision of analysis.

  20. Respiratory protective device design using control system techniques

    NASA Technical Reports Server (NTRS)

    Burgess, W. A.; Yankovich, D.

    1972-01-01

    The feasibility of a control system analysis approach to provide a design base for respiratory protective devices is considered. A system design approach requires that all functions and components of the system be mathematically identified in a model of the RPD. The mathematical notations describe the operation of the components as closely as possible. The individual component mathematical descriptions are then combined to describe the complete RPD. Finally, analysis of the mathematical notation by control system theory is used to derive compensating component values that force the system to operate in a stable and predictable manner.

  1. Adding power to PowerPoint. Add-ons and plug-ins.

    PubMed

    Giannavola, S

    2001-01-01

    Microsoft's PowerPoint (PPT) has been around for about ten years. It works on both the Macintosh and Windows platforms. Many users have a Macintosh at home and a Windows PC in the office and files can be easily transferred. Presentations magazine estimated that 85 percent of all presentations given in the U.S. last year used PPT. These presentations can be done as 35 mm slides, black and white or color overhead transparencies, electronic lectures or the software can be used to produce pages for Web sites. PPT has become the "Swiss Army Knife" for presenters and can be found everywhere. Since PPT has such a large share of the marketplace, a secondary market has developed to cater to PPT users who need something that didn't come in the box. These products are referred to as add-ons or plug-ins. They are available as commercial products, shareware or even directly from Microsoft. This article will look at several of these add-ons and discuss their possible use in a health care media production environment. PMID:11447780

  2. radEq Add-On Module for CFD Solver Loci-CHEM

    NASA Technical Reports Server (NTRS)

    McCloud, Peter

    2013-01-01

    Loci-CHEM to be applied to flow velocities where surface radiation due to heating from compression and friction becomes significant. The module adds a radiation equilibrium boundary condition to the computational fluid dynamics (CFD) code to produce accurate results. The module expanded the upper limit for accurate CFD solutions of Loci-CHEM from Mach 4 to Mach 10 based on Space Shuttle Orbiter Re-Entry trajectories. Loci-CHEM already has a very promising architecture and performance, but absence of radiation equilibrium boundary condition limited the application of Loci-CHEM to below Mach 4. The immediate advantage of the add-on module is that it allows Loci-CHEM to work with supersonic flows up to Mach 10. This transformed Loci-CHEM from a rocket engine- heritage CFD code with general subsonic and low-supersonic applications, to an aeroheating code with hypersonic applications. The follow-on advantage of the module is that it is a building block for additional add-on modules that will solve for the heating generated at Mach numbers higher than 10.

  3. Local gate control in carbon nanotube quantum devices

    NASA Astrophysics Data System (ADS)

    Biercuk, Michael Jordan

    This thesis presents transport measurements of carbon nanotube electronic devices operated in the quantum regime. Nanotubes are contacted by source and drain electrodes, and multiple lithographically-patterned electrostatic gates are aligned to each device. Transport measurements of device conductance or current as a function of local gate voltages reveal that local gates couple primarily to the proximal section of the nanotube, hence providing spatially localized control over carrier density along the nanotube length. Further, using several different techniques we are able to produce local depletion regions along the length of a tube. This phenomenon is explored in detail for different contact metals to the nanotube. We utilize local gating techniques to study multiple quantum dots in carbon nanotubes produced both by naturally occurring defects, and by the controlled application of voltages to depletion gates. We study double quantum dots in detail, where transport measurements reveal honeycomb charge stability diagrams. We extract values of energy-level spacings, capacitances, and interaction energies for this system, and demonstrate independent control over all relevant tunneling rates. We report rf-reflectometry measurements of gate-defined carbon nanotube quantum dots with integrated charge sensors. Aluminum rf-SETs are electrostatically coupled to carbon nanotube devices and detect single electron charging phenomena in the Coulomb blockade regime. Simultaneous correlated measurements of single electron charging are made using reflected rf power from the nanotube itself and from the rf-SET on microsecond time scales. We map charge stability diagrams for the nanotube quantum dot via charge sensing, observing Coulomb charging diamonds beyond the first order. Conductance measurements of carbon nanotubes containing gated local depletion regions exhibit plateaus as a function of gate voltage, spaced by approximately 1e2/h, the quantum of conductance for a single

  4. Failure Analysis and Quality Control of Microwave Devices

    NASA Astrophysics Data System (ADS)

    Ming, Zhimao; Zong, Bo; Bai, Xiaoshu

    2016-02-01

    Microwave devices have been widely used in the communication and navigation and navigation fields. The reliability level of microwave devices is an important factor to affect the reliability of electronic equipment. The statistical analysis for the failure of sixty microwave devices was presented and the main causes of failure were given. The failure is mainly analyzed from three aspects below, the surface failure mechanism, the interior failure mechanism and the failure mechanism of electrode system and encapsulation. The surface failure mechanism is analyzed from four aspects, ionic contamination on the surface, silicon dioxide layer defect, the influence of interface states between silicon and silicon dioxide, radiation ionization trap. The interior failure mechanism is analyzed from two aspects, failure caused by thermal breakdown and failure due to latch-up effect of integrated circuit. The failure mechanism of electrode system and encapsulation is analyzed from two aspects, failure mechanism of metallization system and failure mechanism of metallization system of bonding. Meanwhile, the results showed that operation, process, adjustment, components and using problems were the main causes of failure. The valuable statistical data and analysis results were provided for the quality control of microwave devices.

  5. Control device for clutch and transmission in vehicles

    SciTech Connect

    Miyazawa, T.; Sueshige, H.; Niikawa, Y.; Shimokawa, M.

    1986-09-09

    A control device is described for a clutch and a transmission in a vehicle, comprising: (a) a clutch including a release lever and a clutch spring, and disconnectable by the release lever; (b) a transmission including a plurality of gears for changing the speed of the vehicle and a shifter for selecting one of the gears at a time for operation; (c) a substantially single control lever angularly moveable about at least one shaft for actuating the clutch and the transmission; (d) a first link mechanism for transmitting angular movement of the control lever to the release lever of the clutch; (e) a second link mechanism for transmitting angular movement of the control lever to the shifter of the transmission; (f) a damper for imposing a dampening force during engagement of the clutch, the damper is a hydraulic damper connected to the second link mechanism.

  6. Control devices and steering strategies in pathway surgery.

    PubMed

    Fan, Chunman; Jelínek, Filip; Dodou, Dimitra; Breedveld, Paul

    2015-02-01

    For pathway surgery, that is, minimally invasive procedures carried out transluminally or through instrument-created pathways, handheld maneuverable instruments are being developed. As the accompanying control interfaces of such instruments have not been optimized for intuitive manipulation, we investigated the effect of control mode (1DoF or 2DoF), and control device (joystick or handgrip) on human performance in a navigation task. The experiments were conducted using the Endo-PaC (Endoscopic-Path Controller), a simulator that emulates the shaft and handle of a maneuverable instrument, combined with custom-developed software animating pathway surgical scenarios. Participants were asked to guide a virtual instrument without collisions toward a target located at the end of a virtual curved tunnel. The performance was assessed in terms of task completion time, path length traveled by the virtual instrument, motion smoothness, collision metrics, subjective workload, and personal preference. The results indicate that 2DoF control leads to faster task completion and fewer collisions with the tunnel wall combined with a strong subjective preference compared with 1DoF control. Handgrip control appeared to be more intuitive to master than joystick control. However, the participants experienced greater physical demand and had longer path lengths with handgrip than joystick control. PMID:25438958

  7. Variable Emittance Electrochromic Devices for Satellite Thermal Control

    NASA Astrophysics Data System (ADS)

    Demiryont, Hulya; Shannon, Kenneth C.

    2007-01-01

    An all-solid-state electrochromic device (ECD) was designed for electronic variable emissivity (VE) control. In this paper, a low weight (5g/m2) electrochromic thermal control device, the EclipseVEECD™, is detailed as a viable thermal control system for spacecraft outer surface temperatures. Discussion includes the technology's performance, satellite applications, and preparations for space based testing. This EclipseVEECD™ system comprises substrate/mirror electrode/active element/IR transparent electrode layers. This system tunes and modulates reflection/emittance from 5 μm to 15 μm region. Average reflectance/emittance modulation of the system from the 400 K to 250 K region is about 75%, while at room temperature (9.5 micron) reflectance/emittance is around 90%. Activation voltage of the EclipseVEECD™ is around ±1 Volt. The EclipseVEECD™ can be used as a smart thermal modulator for the thermal control of satellites and spacecraft by monitoring and adjusting the amount of energy emitted from the outer surfaces. The functionality of the EclipseVEECD™ was successfully demonstrated in vacuum using a multi-purpose heat dissipation/absorption test module, the EclipseHEAT™. The EclipseHEAT™ has been successfully flight checked and integrated onto the United States Naval Alchemy MidSTAR satellite, scheduled to launch December 2006.

  8. Magnetic Control of Locked Modes in Present Devices and ITER

    NASA Astrophysics Data System (ADS)

    Volpe, F. A.; Sabbagh, S.; Sweeney, R.; Hender, T.; Kirk, A.; La Haye, R. J.; Strait, E. J.; Ding, Y. H.; Rao, B.; Fietz, S.; Maraschek, M.; Frassinetti, L.; in, Y.; Jeon, Y.; Sakakihara, S.

    2014-10-01

    The toroidal phase of non-rotating (``locked'') neoclassical tearing modes was controlled in several devices by means of applied magnetic perturbations. Evidence is presented from various tokamaks (ASDEX Upgrade, DIII-D, JET, J-TEXT, KSTAR), spherical tori (MAST, NSTX) and a reversed field pinch (EXTRAP-T2R). Furthermore, the phase of interchange modes was controlled in the LHD helical device. These results share a common interpretation in terms of torques acting on the mode. Based on this interpretation, it is predicted that control-coil currents will be sufficient to control the phase of locking in ITER. This will be possible both with the internal coils and with the external error-field-correction coils, and might have promising consequences for disruption avoidance (by aiding the electron cyclotron current drive stabilization of locked modes), as well as for spatially distributing heat loads during disruptions. This work was supported in part by the US Department of Energy under DE-SC0008520, DE-FC-02-04ER54698 and DE-AC02-09CH11466.

  9. Method and device for controlling plume during laser welding

    DOEpatents

    Fuerschbach, Phillip W.; Jellison, James L.; Keicher, David M.; Oberkampf, William L.

    1991-01-01

    A method and apparatus for enhancing the weldment of a laser welding system is provided. The laser weld plume control device includes a cylindrical body defining an upside-down cone cavity; the upper surface of the body circumscribes the base of the cone cavity, and the vertex of the cone cavity forms an orifice concentrically located with respect to the laser beam and the plume which forms as a result of the welding operation. According to the method of the invention, gas is directed radially inward through inlets in the upper surface of the body into and through channels in the wall of the body and finally through the orifice of the body, and downward onto the surface of the weldment. The gas flow is then converted by the orifice of the device from radial flow to an axisymmetric gas jet flowing away from the weldment surface in a direction perpendicular to the surface and opposite to that of the laser.

  10. Microfluidic devices for the controlled manipulation of small volumes

    DOEpatents

    Ramsey, J Michael [Knoxville, TN; Jacobson, Stephen C [Knoxville, TN

    2007-07-03

    A method for conducting a broad range of biochemical analyses or manipulations on a series of nano- to subnanoliter reaction volumes and an apparatus for carrying out the same are disclosed. The invention is implemented on a fluidic microchip to provide high serial throughput. In particular, the disclosed device is a microfabricated channel device that can manipulate nanoliter or subnanoliter reaction volumes in a controlled manner to produce results at rates of 1 to 10 Hz per channel. The reaction volumes are manipulated in serial fashion analogous to a digital shift register. The invention has application to such problems as screening molecular or cellular targets using single beads from split-synthesis combinatorial libraries, screening single cells for RNA or protein expression, genetic diagnostic screening at the single cell level, or performing single cell signal transduction studies.

  11. Active terahertz device based on optically controlled organometal halide perovskite

    NASA Astrophysics Data System (ADS)

    Zhang, Bo; Lv, Longfeng; He, Ting; Chen, Tianji; Zang, Mengdi; Zhong, Liang; Wang, Xinke; Shen, Jingling; Hou, Yanbing

    2015-08-01

    An active all-optical high-efficiency broadband terahertz device based on an organometal halide perovskite (CH3NH3PbI3, MAPbI3)/inorganic (Si) structure is investigated. Spectrally broadband modulation of the THz transmission is obtained in the frequency range from 0.2 to 2.6 THz, and a modulation depth of nearly 100% can be achieved with a low-level photoexcitation power (˜0.4 W/cm2). Both THz transmission and reflection were suppressed in the MAPbI3/Si structure by an external continuous-wave (CW) laser. Enhancement of the charge carrier density at the MAPbI3/Si interface is crucial for photo-induced absorption. The results show that the proposed high-efficiency broadband optically controlled terahertz device based on the MAPbI3/Si structure has been realized.

  12. Microfluidic devices for the controlled manipulation of small volumes

    DOEpatents

    Ramsey, Michael J; Jacobson, Stephen C

    2012-09-18

    A method for conducting a broad range of biochemical analyses or manipulations on a series of nano- to subnanoliter reaction volumes and an apparatus for carrying out the same are disclosed. The invention is implemented on a fluidic microchip to provide high serial throughput. In particular, the disclosed device is a microfabricated channel device that can manipulate nanoliter or subnanoliter reaction volumes in a controlled manner to produce results at rates of 1 to 10 Hz per channel. The reaction volumes are manipulated in serial fashion analogous to a digital shift register. The invention has application to such problems as screening molecular or cellular targets using single beads from split-synthesis combinatorial libraries, screening single cells for RNA or protein expression, genetic diagnostic screening at the single cell level, or performing single cell signal transduction studies.

  13. Evaluation of four cursor control devices during a target acquisition task for laparoscopic tool control.

    PubMed

    Herring, S R; Trejo, A E; Hallbeck, M S

    2010-01-01

    Current laparoscopic surgery instruments create awkward postures which produce fatigue and pressure points in surgeons. In order to alleviate some of this discomfort a new laparoscopic tool had been developed with the inclusion of an articulating end-effector manipulated by a trackball. The current study was developed to access the performance of four input devices which could replace the manual trackball in a powered laparoscopic tool. A simple Fitts' law task was conducted and the devices' performance was evaluated with both subjective and objective measures. This article makes three main contributions to the scientific community. First, it provides a comparison of four control devices (TouchPad, Mouse Button Module, MiniJoystick Module and MicroJoystick) for use in a powered laparoscopic tool. Second, it provides an understanding of how the non-traditional measure of target re-entry can be utilized to compare control devices and how this relates to the more traditional measures of throughput and error rate. Finally, it contributes to the understanding of how a user's familiarity with a control device could affect the subjective and objective performance of the device. The main results indicate that the TouchPad and MicroJoystick are the best candidate-devices for use in a powered laparoscopic tool. The article also provides support for utilizing the new measure target re-entry when comparing control performance. Although studied in the application of laparoscopic surgery, the results can be generalized for the design of any hand-held device in which the speed and accuracy of the control device is critical. PMID:19426963

  14. Controlled growth of Si nanowire arrays for device integration.

    PubMed

    Hochbaum, Allon I; Fan, Rong; He, Rongrui; Yang, Peidong

    2005-03-01

    Silicon nanowires were synthesized, in a controlled manner, for their practical integration into devices. Gold colloids were used for nanowire synthesis by the vapor-liquid-solid growth mechanism. Using SiCl4 as the precursor gas in a chemical vapor deposition system, nanowire arrays were grown vertically aligned with respect to the substrate. By manipulating the colloid deposition on the substrate, highly controlled growth of aligned silicon nanowires was achieved. Nanowire arrays were synthesized with narrow size distributions dictated by the seeding colloids and with average diameters down to 39 nm. The density of wire growth was successfully varied from approximately 0.1-1.8 wires/microm2. Patterned deposition of the colloids led to confinement of the vertical nanowire growth to selected regions. In addition, Si nanowires were grown directly into microchannels to demonstrate the flexibility of the deposition technique. By controlling various aspects of nanowire growth, these methods will enable their efficient and economical incorporation into devices. PMID:15755094

  15. How add-on solutions can extend the life of static OADMs and protect carrier investment

    NASA Astrophysics Data System (ADS)

    Queller, Abe; Kronenthal, Guy

    2004-10-01

    While most OADM systems deployed today are static, carriers offering new wavelength services, are looking for ways to migrate towards reconfigurable OADM and dynamically reconfigurable OADM. ROADMs allow carriers to automate service provisioning, wavelength management and failsafe mechanisms, thereby eliminating slow, costly and error-prone manual network configuration. And although next-generation systems offer this flexibility as an integral part of their architecture, carriers must protect their existing investment, extending the life of their existing networks. This article examines the use of add-on optical switching systems, as a cost- and time-effective means for upgrading legacy networks. Two examples are given. In the first, a static OADM is upgraded into a reconfigurable system. The second example shows how existing OADM systems can be upgraded to support dynamic reconfigurability. The article examines also particular advantages of Planar Lightwave Circuits (PLC) for these applications.

  16. Space station systems technology study (add-on task). Volume 2: Trade study and technology selection

    NASA Technical Reports Server (NTRS)

    1985-01-01

    The current Space Station Systems Technology Study add on task was an outgrowth of the Advanced Platform Systems Technology Study (APSTS) that was completed in April 1983 and the subsequent Space Station System Technology Study completed in April 1984. The first APSTS proceeded from the identification of 106 technology topics to the selection of five for detailed trade studies. During the advanced platform study, the technical issues and options were evaluated through detailed trade processes, individual consideration was given to costs and benefits for the technologies identified for advancement, and advancement plans were developed. An approach similar to that was used in the subsequent study, with emphasis on system definition in four specific technology areas to facilitate a more in depth analysis of technology issues.

  17. Flunarizine as add-on therapy in epilepsy. Crossover study vs placebo.

    PubMed

    Moglia, A; Bergamasco, B; Di Perri, R; Mancia, D

    1986-01-01

    The anticonvulsive effect of flunarizine was studied in a multicenter trial, by means of a randomized, double-blind, single crossover design. The subjects who entered the study were 51 males and 39 females, aged 15 to 73 years. They were epileptic patients who suffered from at least two generalized seizures per month or more than 4 partial seizures per month. The patients were already being treated with major antiepileptic drugs. Flunarizine was administered in a single evening dose of 10 mg/die in patients who weighed less than 70 kg and of 15 mg/die in patients who weighed more 70 kg. Our results show that flunarizine, given as add-on therapy, produced a slight but significant decrease in the number of monthly seizures at the end of a 3-month period, while placebo did not significantly change the seizures frequency. PMID:3301560

  18. Addiction surplus: the add-on margin that makes addictive consumptions difficult to contain.

    PubMed

    Adams, Peter J; Livingstone, Charles

    2015-01-01

    Addictive consumptions generate financial surpluses over-and-above non-addictive consumptions because of the excessive consumption of addicted consumers. This add-on margin or 'addiction surplus' provides a powerful incentive for beneficiaries to protect their income by ensuring addicted consumers keep consuming. Not only that, addiction surplus provides the financial base that enables producers to sponsor activities which aim to prevent public health initiatives from reducing consumption. This paper examines the potency of addiction surplus to engage industry, governments and communities in an on-going reliance on addiction surplus. It then explores how neo-liberal constructions of a rational consumer disguise the ethical and exploitative dynamics of addiction surplus by examining ways in which addictive consumptions fail to conform to notions of autonomy and rationality. Four measures are identified to contain the distorting effects of addiction surplus. PMID:25175598

  19. A voice-controlled network for universal control of devices in the OR.

    PubMed

    Roe, D B; Wang, Y

    2000-01-01

    To achieve the benefits of an Intelligent Operating Room (OR), we envision an OR control center--a voice-controlled network of medical devices. This central controller allows doctors and nurses to control many smart devices in a minimally-invasive OR, in the same way the operating system of a personal computer allows users to control computer peripherals, such as a printer or modem. Surgeons in the OR may use voice commands to control surgical devices when their hands are busy. In addition, the OR staff may use a touch-sensitive display panel to control any device in the OR from a single, convenient location. As an example, this paper describes a new 'operating system for the OR', called HERMES. Because of the unique demands of the Intelligent OR, the design of such a voice-control network involves several challenges: safety, reliability and ease of use. This paper discusses the design strategies for the HERMES control network and presents findings from the use of commercial HERMES in operating rooms. PMID:20156013

  20. Methods of measurement for semiconductor materials, process control, and devices

    NASA Technical Reports Server (NTRS)

    Bullis, W. M. (Editor)

    1972-01-01

    Activities directed toward the development of methods of measurement for semiconductor materials, process control, and devices are described. Topics investigated include: measurements of transistor delay time; application of the infrared response technique to the study of radiation-damaged, lithium-drifted silicon detectors; and identification of a condition that minimizes wire flexure and reduces the failure rate of wire bonds in transistors and integrated circuits under slow thermal cycling conditions. Supplementary data concerning staff, standards committee activities, technical services, and publications are included as appendixes.

  1. Variable control of neutron albedo in toroidal fusion devices

    DOEpatents

    Jassby, Daniel L.; Micklich, Bradley J.

    1986-01-01

    An arrangement is provided for controlling neutron albedo in toroidal fusion devices having inboard and outboard vacuum vessel walls for containment of the neutrons of a fusion plasma. Neutron albedo material is disposed immediately adjacent the inboard wall, and is movable, preferably in vertical directions, so as to be brought into and out of neutron modifying communication with the fusion neutrons. Neutron albedo material preferably comprises a liquid form, but may also take pebble, stringer and curtain-like forms. A neutron flux valve, rotatable about a vertical axis is also disclosed.

  2. Modeling and Control of the Automated Radiator Inspection Device

    NASA Technical Reports Server (NTRS)

    Dawson, Darren

    1991-01-01

    Many of the operations performed at the Kennedy Space Center (KSC) are dangerous and repetitive tasks which make them ideal candidates for robotic applications. For one specific application, KSC is currently in the process of designing and constructing a robot called the Automated Radiator Inspection Device (ARID), to inspect the radiator panels on the orbiter. The following aspects of the ARID project are discussed: modeling of the ARID; design of control algorithms; and nonlinear based simulation of the ARID. Recommendations to assist KSC personnel in the successful completion of the ARID project are given.

  3. Methods of measurement for semiconductor materials, process control, and devices

    NASA Technical Reports Server (NTRS)

    Bullis, W. M. (Editor)

    1971-01-01

    The development of methods of measurement for semiconductor materials, process control, and devices is discussed. The following subjects are also presented: (1) demonstration of the high sensitivity of the infrared response technique by the identification of gold in a germanium diode, (2) verification that transient thermal response is significantly more sensitive to the presence of voids in die attachment than steady-state thermal resistance, and (3) development of equipment for determining susceptibility of transistors to hot spot formation by the current-gain technique.

  4. The CONVEX Liner Add-On to the DIAMOND-FORTUNE event

    SciTech Connect

    Heuze, F.E.; Swift, R.P.; Hill, L.R.; Barrett, W.H.

    1993-11-15

    This report describes the execution of the CONVEX Liner Add-On to the DIAMOND FORTUNE low-yield cavity test of the Defense Nuclear Agency. CONVEX stands for COntained Nuclear Vessel EXperiment. It concerns the design of underground chambers where repeated low-yield nuclear explosions could be conducted. The approach proposed by the first author in the early 1980`s was to engineer a steel-lined rock cavern where the steel liner would be prestressed against the rock by tendons and/or bolts. These would daylight in tunnels surrounding the main cavity. From there, they could be initially tensioned and retensioned, if needed, after each test. The CONVEX Liner Add-On to DIAMOND FORTUNE consisted of anchoring a 1.4-m square, 2.5-cm thick steel plate to the wall of the cavity, using a 5-cm diameter center bolt, and four 2.5-cm diameter comer bolts. The bolts daylighted in a drift surrounding the gallery, and separated from it by a 9-m thick rock pillar. The liner plate, the bolts, and the rock pillar were equipped with 23 gages to describe the thermal and mechanical response of the system during pretensioning, during the dynamic loading phase, and post-test. Particular emphasis was given to obtaining the response both upon loading and during the rebound of the system, in order to determine whether the plate ever separated from the rock. So, the main operational objectives of this project were to acquire response data of the system under nuclear loading and to ascertain the status of contact between the steel plate and the rock, as shown by toadstool data and bolt tension data. The instrumentation and data acquisition system performed extremely well. Data were recorded during the dynamic phase; plate temperature was monitored for several hours after the test; and the remaining tension was obtained for several bolts more than three months after the test, upon re-entry in the runaround drift.

  5. Polymeric barrier membranes for device packaging, diffusive control and biocompatibility

    NASA Astrophysics Data System (ADS)

    Wasikiewicz, J. M.; Roohpour, N.; Paul, D.; Grahn, M.; Ateh, D.; Rehman, I.; Vadgama, P.

    2008-11-01

    Current state-of-the-art implantable micron feature electronic devices are capable of monitoring and stimulating functions in vivo. Within an EU Framework VI project a further step was taken in developing key microsystem technologies and communication methods that could bring intelligence directly to the human interface, in the form of reactive medical implants and ambulatory measurement systems. Information from these devices is planned to be transmitted out into the wider environment for remote processing. However, the packaging of such state-of-the-art devices to enhance tissue biocompatibility, and to protect conducting elements from in vivo corrosion during extended use, along with protecting the body from toxins leaching from implant components, remains a concern. Candidate polymeric barriers as hydration resistant and solute impermeable interfaces to mitigate such major problems of chronic implantation were investigated. Materials studied included silicone rubber, PVC, polyurethane, and diamond-like carbon (DLC). Polymer permeability to water solutes was marginally improved through incorporation of lipid into these structures. Surface biocompatibility was assessed on the basis of protein film deposition in vitro and by cell viability studies in tissue culture. Short-term toxicity was not observed for any of the tested materials, though there were substantial differences in hydration. Additionally, polypyrrole over active electrodes shows feasibility for controlled tissue interfacing whilst retaining electrical conductivity.

  6. Device for controlling the pouring of molten materials

    DOEpatents

    Moore, Alan F.; Duncan, Alfred L.

    1994-01-01

    A device for controlling the pouring of a molten material from a crucible or other container. The device (10) includes an annular retainer ring (12) for mounting in the drain opening in the bottom of a conventional crucible (16), the retainer ring defining a opening (14) therethrough. The device (10) also includes a plug member (22) having an annular forward end portion (24) for force-fit reception in the opening (14) of the retainer ring (12) to selectively seal the opening (14) and for being selectively forced through the opening (14). The plug member (22) has a rear end portion (26) for being positioned within the crucible (16), the rear end portion (26) including stop means for prohibiting the rear end portion from passing through the opening (14) in the retainer ring (12) when the forward end portion (24) is selectively forced through the opening. The plug member (22) defines at least one, and preferably a plurality of flutes (32), each extending from a point rearward the annular forward end portion (24) of the plug member (22), and forward the stop means, to a point rearward of the stop means. The flutes (32) permit fluid communication between the interior and exterior of the crucible (16) when the forward end portion (24) of the plug member (22) is forced through the opening (14) in the retaining ring (12) such that the molten material is allowed to flow from the crucible (16).

  7. Device for controlling the pouring of molten materials

    DOEpatents

    Moore, A.F.; Duncan, A.L.

    1994-02-15

    A device is described for controlling the pouring of a molten material from a crucible or other container. The device includes an annular retainer ring for mounting in the drain opening in the bottom of a conventional crucible, the retainer ring defining a opening there through. The device also includes a plug member having an annular forward end portion for force-fit reception in the opening of the retainer ring to selectively seal the opening and for being selectively forced through the opening. The plug member has a rear end portion for being positioned within the crucible, the rear end portion including stop means for prohibiting the rear end portion from passing through the opening in the retainer ring when the forward end portion is selectively forced through the opening. The plug member defines at least one, and preferably a plurality of flutes, each extending from a point rearward the annular forward end portion of the plug member, and forward the stop means, to a point rearward of the stop means. The flutes permit fluid communication between the interior and exterior of the crucible when the forward end portion of the plug member is forced through the opening in the retaining ring such that the molten material is allowed to flow from the crucible. 5 figures.

  8. Microfluidic devices for the controlled manipulation of small volumes

    DOEpatents

    Ramsey, J Michael [Knoxville, TN; Jacobson, Stephen C [Knoxville, TN

    2003-02-25

    A method for conducting a broad range of biochemical analyses or manipulations on a series of nano- to subnanoliter reaction volumes and an apparatus for carrying out the same are disclosed. The method and apparatus are implemented on a fluidic microchip to provide high serial throughput. The method and device of the invention also lend themselves to multiple parallel analyses and manipulation to provide greater throughput for the generation of biochemical information. In particular, the disclosed device is a microfabricated channel device that can manipulate nanoliter or subnanoliter biochemical reaction volumes in a controlled manner to produce results at rates of 1 to 10 Hz per channel. The individual reaction volumes are manipulated in serial fashion analogous to a digital shift register. The method and apparatus according to this invention have application to such problems as screening molecular or cellular targets using single beads from split-synthesis combinatorial libraries, screening single cells for RNA or protein expression, genetic diagnostic screening at the single cell level, or performing single cell signal transduction studies.

  9. Manual shift control lever device and self-contained electronic control for transmissions

    SciTech Connect

    Parker, F.F.

    1986-09-09

    A unitized shift control lever device is described for the remote activation of an electrically controlled transmission comprising: a housing; a manually operable range selector lever pivotally supported in the housing for selective movements to predetermined operating positions respectively indicative of a required operating condition of an associated electrically controlled transmission; means in the housing providing a source of radiations; radiation controlled switching means for generating discrete control signals in response to the presence and non-presence of the radiations; means interposed in the radiation path between the source and the switching means operable in response to the movement of the range selector lever for selectively determining the presence or non-presence of the radiations with respect to the switching means at each range selector position of the lever; and electronic circuit control means having input connections for receiving the generated signals and output connections adapted for connection with electrically activated condition controlling devices on the transmission.

  10. Conjugated polymer based active electric-controlled terahertz device

    NASA Astrophysics Data System (ADS)

    Zhong, Liang; Zhang, Bo; He, Ting; Lv, Longfeng; Hou, Yanbing; Shen, Jingling

    2016-03-01

    A modulation of terahertz response in a highly efficient, electric-controlled conjugated polymer-silicon hybrid device with low photo-excitation was investigated. The polymer-silicon forms a hybrid structure, where the active depletion region modifies the semiconductor conductivity in real time by applying an external bias voltage. The THz transmission was efficiently modulated by effective controlling. In a THz-TDS system, the modulation depth reached nearly 100% when the applied voltage was 3.8 V at an external laser intensity of 0.3 W/cm2. The saturation voltage decreased with increasing photo-excited intensity. In a THz-CW system, a significant decline in THz transmission was also observed with increasing applied bias voltage. This reduction in THz transmission is induced by the enhancement of carrier density.

  11. Use of piezoelectric devices to control snowboard vibrations

    NASA Astrophysics Data System (ADS)

    Bianchini, Emanuele; Spangler, Ronald L., Jr.; Andrus, Cameron

    1998-07-01

    This paper explains how piezoelectric devices can be used to control vibrations in a snowboard. Furthermore the details of the approach, testing, design and analysis of a piezoelectric damper applied to a production snowboard are described here. The approach consisted of determining the principal modes of vibration of a snowboard during its operation (on-slope). This information was used to develop a finite element model of the structure. The finite element model was used to find the areas of higher strain energy where a piezoelectric device could be applied and be effective in reducing undesired vibrations. Several prototype piezoelectric dampers were built, applied to snowboards and tested on snow. The proper amount of damping was selected by the test riders, so that a configuration could be selected for production of the 1998 K2 Electra snowboard. The piezoelectric damper selected reduced the snowboard vibration by 75% at the mode to which it was tuned, allowing for a smoother ride and a more precise control of the snowboard in any kind of snow condition.

  12. Equilibria near asteroids for solar sails with reflection control devices

    NASA Astrophysics Data System (ADS)

    Gong, Shengping; Li, Junfeng

    2015-02-01

    Solar sails are well-suited for long-term, multiple-asteroid missions. The dynamics of solar sails near an asteroid have not yet been studied in detail. In this paper, out-of-plane artificial equilibria in a Sun-asteroid rotating frame and hovering points in a body-fixed rotating frame are studied (using a solar sail equipped with reflection control devices). First, the dynamics and the stability of out-of-plane artificial equilibria are studied as an elliptical restricted three body problem. Next, the body-fixed hovering problem is discussed as a two-body problem. Hovering flight is only possible for certain values of the latitude of the asteroid's orbit. In addition, the feasible range of latitudes is determined for each landmark on the asteroid's surface. The influence of the sail lightness number on the feasible range is also illustrated. Several special families of hovering points are discussed. These points include points above the equator and poles and points with an altitude equal to the radius of the synchronous orbit. In both of these types of problems, the solar sail (equipped with reflection control devices) can equilibrate over a large range of locations.

  13. Patient Machine Interface for the Control of Mechanical Ventilation Devices

    PubMed Central

    Grave de Peralta, Rolando; Gonzalez Andino, Sara; Perrig, Stephen

    2013-01-01

    The potential of Brain Computer Interfaces (BCIs) to translate brain activity into commands to control external devices during mechanical ventilation (MV) remains largely unexplored. This is surprising since the amount of patients that might benefit from such assistance is considerably larger than the number of patients requiring BCI for motor control. Given the transient nature of MV (i.e., used mainly over night or during acute clinical conditions), precluding the use of invasive methods, and inspired by current research on BCIs, we argue that scalp recorded EEG (electroencephalography) signals can provide a non-invasive direct communication pathway between the brain and the ventilator. In this paper we propose a Patient Ventilator Interface (PVI) to control a ventilator during variable conscious states (i.e., wake, sleep, etc.). After a brief introduction on the neural control of breathing and the clinical conditions requiring the use of MV we discuss the conventional techniques used during MV. The schema of the PVI is presented followed by a description of the neural signals that can be used for the on-line control. To illustrate the full approach, we present data from a healthy subject, where the inspiration and expiration periods during voluntary breathing were discriminated with a 92% accuracy (10-fold cross-validation) from the scalp EEG data. The paper ends with a discussion on the advantages and obstacles that can be forecasted in this novel application of the concept of BCI. PMID:24961620

  14. Stable and Intuitive Control of an Intelligent Assist Device.

    PubMed

    Duchaine, V; Mayer St-Onge, Boris; Dalong Gao; Gosselin, C

    2012-01-01

    Safety and dependability are of the utmost importance for physical human-robot interaction due to the potential risks that a relatively powerful robot poses to human beings. From the control standpoint, it is possible to improve safety by guaranteeing that the robot will never exhibit any unstable behavior. However, stability is not the only concern in the design of a controller for such a robot. During human-robot interaction, the resulting cooperative motion should be truly intuitive and should not restrict in any way the human performance. For this purpose, we have designed a new variable admittance control law that guarantees the stability of the robot during constrained motion and also provides a very intuitive human interaction. The former characteristic is provided by the design of a stability observer while the latter is based on a variable admittance control scheme that uses the time derivative of the contact force to assess human intentions. The stability observer is based on a previously published stability investigation of cooperative motion which implies the knowledge of the interaction stiffness. A method to accurately estimate this stiffness online using the data coming from the encoder and from a multiaxis force sensor at the end effector is also provided. The stability and intuitivity of the control law are verified in a user study involving a cooperative drawing task with a 3 degree-of-freedom (dof) parallel robot as well as in experiments performed with a prototype of an industrial Intelligent Assist Device. PMID:26964071

  15. 23 CFR 630.1110 - Maintenance of temporary traffic control devices.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 23 Highways 1 2013-04-01 2013-04-01 false Maintenance of temporary traffic control devices. 630... AND TRAFFIC OPERATIONS PRECONSTRUCTION PROCEDURES Temporary Traffic Control Devices § 630.1110 Maintenance of temporary traffic control devices. To provide for the continued effectiveness of...

  16. 23 CFR 630.1110 - Maintenance of temporary traffic control devices.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 23 Highways 1 2011-04-01 2011-04-01 false Maintenance of temporary traffic control devices. 630... AND TRAFFIC OPERATIONS PRECONSTRUCTION PROCEDURES Temporary Traffic Control Devices § 630.1110 Maintenance of temporary traffic control devices. To provide for the continued effectiveness of...

  17. 23 CFR 630.1110 - Maintenance of temporary traffic control devices.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Maintenance of temporary traffic control devices. 630... AND TRAFFIC OPERATIONS PRECONSTRUCTION PROCEDURES Temporary Traffic Control Devices § 630.1110 Maintenance of temporary traffic control devices. To provide for the continued effectiveness of...

  18. 23 CFR 630.1110 - Maintenance of temporary traffic control devices.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 23 Highways 1 2012-04-01 2012-04-01 false Maintenance of temporary traffic control devices. 630... AND TRAFFIC OPERATIONS PRECONSTRUCTION PROCEDURES Temporary Traffic Control Devices § 630.1110 Maintenance of temporary traffic control devices. To provide for the continued effectiveness of...

  19. 40 CFR 1700.14 - Marine Pollution Control Device (MPCD) Performance Standards. [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 34 2012-07-01 2012-07-01 false Marine Pollution Control Device (MPCD... DISCHARGE STANDARDS FOR VESSELS OF THE ARMED FORCES Marine Pollution Control Device (MPCD) Performance Standards § 1700.14 Marine Pollution Control Device (MPCD) Performance Standards....

  20. 40 CFR 1700.14 - Marine Pollution Control Device (MPCD) Performance Standards. [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 34 2013-07-01 2013-07-01 false Marine Pollution Control Device (MPCD... DISCHARGE STANDARDS FOR VESSELS OF THE ARMED FORCES Marine Pollution Control Device (MPCD) Performance Standards § 1700.14 Marine Pollution Control Device (MPCD) Performance Standards....

  1. 40 CFR 1700.14 - Marine Pollution Control Device (MPCD) Performance Standards. [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 33 2014-07-01 2014-07-01 false Marine Pollution Control Device (MPCD... DISCHARGE STANDARDS FOR VESSELS OF THE ARMED FORCES Marine Pollution Control Device (MPCD) Performance Standards § 1700.14 Marine Pollution Control Device (MPCD) Performance Standards....

  2. 40 CFR 1700.14 - Marine Pollution Control Device (MPCD) Performance Standards. [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 33 2011-07-01 2011-07-01 false Marine Pollution Control Device (MPCD... DISCHARGE STANDARDS FOR VESSELS OF THE ARMED FORCES Marine Pollution Control Device (MPCD) Performance Standards § 1700.14 Marine Pollution Control Device (MPCD) Performance Standards....

  3. 40 CFR 63.2268 - Initial compliance demonstration for a wet control device.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... control device is contained or destroyed to minimize re-release to the atmosphere such that the desired... wet control device. 63.2268 Section 63.2268 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Initial Compliance Requirements § 63.2268 Initial compliance demonstration for a wet control device....

  4. 40 CFR 63.2268 - Initial compliance demonstration for a wet control device.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... control device is contained or destroyed to minimize re-release to the atmosphere such that the desired... wet control device. 63.2268 Section 63.2268 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Initial Compliance Requirements § 63.2268 Initial compliance demonstration for a wet control device....

  5. 40 CFR 65.156 - General monitoring requirements for control and recovery devices.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... control and recovery devices. 65.156 Section 65.156 Protection of Environment ENVIRONMENTAL PROTECTION... control and recovery devices. (a) General monitoring requirement applicability. (1) This section applies... parameters is outside the permitted range. (ii) When the period of control or recovery device operation is...

  6. 40 CFR 65.156 - General monitoring requirements for control and recovery devices.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... control and recovery devices. 65.156 Section 65.156 Protection of Environment ENVIRONMENTAL PROTECTION... control and recovery devices. (a) General monitoring requirement applicability. (1) This section applies... parameters is outside the permitted range. (ii) When the period of control or recovery device operation is...

  7. 40 CFR 65.156 - General monitoring requirements for control and recovery devices.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... control and recovery devices. 65.156 Section 65.156 Protection of Environment ENVIRONMENTAL PROTECTION... control and recovery devices. (a) General monitoring requirement applicability. (1) This section applies... parameters is outside the permitted range. (ii) When the period of control or recovery device operation is...

  8. 40 CFR 1700.14 - Marine Pollution Control Device (MPCD) Performance Standards. [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Marine Pollution Control Device (MPCD... DISCHARGE STANDARDS FOR VESSELS OF THE ARMED FORCES Marine Pollution Control Device (MPCD) Performance Standards § 1700.14 Marine Pollution Control Device (MPCD) Performance Standards....

  9. Method and apparatus for actively controlling a micro-scale flexural plate wave device

    DOEpatents

    Dohner, Jeffrey L.

    2001-01-01

    An actively controlled flexural plate wave device provides a micro-scale pump. A method of actively controlling a flexural plate wave device produces traveling waves in the device by coordinating the interaction of a magnetic field with actively controlled currents. An actively-controlled flexural plate wave device can be placed in a fluid channel and adapted for use as a micro-scale fluid pump to cool or drive micro-scale systems, for example, micro-chips, micro-electrical-mechanical devices, micro-fluid circuits, or micro-scale chemical analysis devices.

  10. Control device for controlling the operation of a supercharger in an internal combustion engine

    SciTech Connect

    Horii, K.

    1987-04-28

    An internal combustion engine is described having a crankshaft and a supercharger mechanically driven by and connected to the crankshaft via an electromagentic clutch, a control device for controlling the operation of the supercharger in response to engine operating conditions, comprising, a first sensor means for detecting a temperature of the engine, a second sensor means for detecting racing of the engine, and a control means responsive to outputs from the first and second sensors for causing the electromagnetic clutch to be disengaged.

  11. Using ERF Devices to Control Deployments of Space Structures

    NASA Technical Reports Server (NTRS)

    Bar-Cohen, Yoseph; Chang, Zensheu; Salama, Moktar; Bao, Xiaoqi; Sherrit, Steward; Jenkins, Christopher; Vinogradov, Aleksandra

    2003-01-01

    A report proposes devices containing electrorheological fluids (ERFs) damper for controlling deployments of lightweight, flexible structures in outer space. The structures would include spring members that could be wound or compressed for compact stowage during transport. The ERF based damper would keep the structures compacted and/or regulate the speeds with which the structures would spring out for deployment. After deployment, ERF based dampening mechanism could be used to rigidize the structures or damp their vibrations. An experimental ERF deployment controlled structure described in the report comprised two metal carpenter s measuring tapes sandwiched together, held slightly apart by rubber-band spacers, and placed in a bag filled with an ERF. The viscosity of the ERF varied with the voltage applied to the tapes, such that it was possible to hold the tapes in the wound condition or slow the speed with which they sprung from the wound to the straight condition. The report describes several potential variations on the basic concept of an ERF-controlled structural member, including compartmentalization of the interior volume to prevent total loss of the ERF in case of a leak and the use of multiple, individually addressable electrode pairs to enable more localized control.

  12. Prospective open-label study of add-on and monotherapy topiramate in civilians with chronic nonhallucinatory posttraumatic stress disorder

    PubMed Central

    Berlant, Jeffrey L

    2004-01-01

    Background In order to confirm therapeutic effects of topiramate on posttraumatic stress disorder (PTSD) observed in a prior study, a new prospective, open-label study was conducted to examine acute responses in chronic, nonhallucinatory PTSD. Methods Thirty-three consecutive newly recruited civilian adult outpatients (mean age 46 years, 85% female) with DSM-IV-diagnosed chronic PTSD, excluding those with concurrent auditory or visual hallucinations, received topiramate either as monotherapy (n = 5) or augmentation (n = 28). The primary measure was a change in the PTSD Checklist-Civilian Version (PCL-C) score from baseline to 4 weeks, with response defined as a ≥ 30% reduction of PTSD symptoms. Results For those taking the PCL-C at both baseline and week 4 (n = 30), total symptoms declined by 49% at week 4 (paired t-test, P < 0.001) with similar subscale reductions for reexperiencing, avoidance/numbing, and hyperarousal symptoms. The response rate at week 4 was 77%. Age, sex, bipolar comorbidity, age at onset of PTSD, duration of symptoms, severity of baseline PCL-C score, and monotherapy versus add-on medication administration did not predict reduction in PTSD symptoms. Median time to full response was 9 days and median dosage was 50 mg/day. Conclusions Promising open-label findings in a new sample converge with findings of a previous study. The use of topiramate for treatment of chronic PTSD, at least in civilians, warrants controlled clinical trials. PMID:15315714

  13. Virtual collaborative environments: programming and controlling robotic devices remotely

    NASA Astrophysics Data System (ADS)

    Davies, Brady R.; McDonald, Michael J., Jr.; Harrigan, Raymond W.

    1995-12-01

    This paper describes a technology for remote sharing of intelligent electro-mechanical devices. An architecture and actual system have been developed and tested, based on the proposed National Information Infrastructure (NII) or Information Highway, to facilitate programming and control of intelligent programmable machines (like robots, machine tools, etc.). Using appropriate geometric models, integrated sensors, video systems, and computing hardware; computer controlled resources owned and operated by different (in a geographic sense as well as legal sense) entities can be individually or simultaneously programmed and controlled from one or more remote locations. Remote programming and control of intelligent machines will create significant opportunities for sharing of expensive capital equipment. Using the technology described in this paper, university researchers, manufacturing entities, automation consultants, design entities, and others can directly access robotic and machining facilities located across the country. Disparate electro-mechanical resources will be shared in a manner similar to the way supercomputers are accessed by multiple users. Using this technology, it will be possible for researchers developing new robot control algorithms to validate models and algorithms right from their university labs without ever owning a robot. Manufacturers will be able to model, simulate, and measure the performance of prospective robots before selecting robot hardware optimally suited for their intended application. Designers will be able to access CNC machining centers across the country to fabricate prototypic parts during product design validation. An existing prototype architecture and system has been developed and proven. Programming and control of a large gantry robot located at Sandia National Laboratories in Albuquerque, New Mexico, was demonstrated from such remote locations as Washington D.C., Washington State, and Southern California.

  14. Controllable spin-charge transport in strained graphene nanoribbon devices

    SciTech Connect

    Diniz, Ginetom S. Guassi, Marcos R.; Qu, Fanyao

    2014-09-21

    We theoretically investigate the spin-charge transport in two-terminal device of graphene nanoribbons in the presence of a uniform uniaxial strain, spin-orbit coupling, exchange field, and smooth staggered potential. We show that the direction of applied strain can efficiently tune strain-strength induced oscillation of band-gap of armchair graphene nanoribbon (AGNR). It is also found that electronic conductance in both AGNR and zigzag graphene nanoribbon (ZGNR) oscillates with Rashba spin-orbit coupling akin to the Datta-Das field effect transistor. Two distinct strain response regimes of electronic conductance as function of spin-orbit couplings magnitude are found. In the regime of small strain, conductance of ZGNR presents stronger strain dependence along the longitudinal direction of strain. Whereas for high values of strain shows larger effect for the transversal direction. Furthermore, the local density of states shows that depending on the smoothness of the staggered potential, the edge states of AGNR can either emerge or be suppressed. These emerging states can be determined experimentally by either spatially scanning tunneling microscope or by scanning tunneling spectroscopy. Our findings open up new paradigms of manipulation and control of strained graphene based nanostructure for application on novel topological quantum devices.

  15. Physical processes in grid control gas discharge device Tacitron

    NASA Astrophysics Data System (ADS)

    Arefiev, Alexander; Vereschagin, Nicolay; Kruglov, Sergey

    2003-10-01

    Physical processes in grid control gas discharge device Tacitron Arefjev A.S., Vereschagin N.M., Kruglov S. A. Radioengineering Academy, Ryazan, Russia Nowdays pulsed power units is getting widely used for cleaning biogas and water. Their parameters and dimension defines by the current commutator, which is used as a switch for interrupting the current in the circuit. Experimental investigations have been carried out to find out the propeties of the one type of the current commutator - the so-called tacitron. It has specific construction of the control grid ,which enables to control the moment of the discharge plasma distinguish and consequently a tacitron has ability to distinguish the discharge, e.i. to interrupt the current, flowing through the device. The grid of a tacitron is constructed of small-mesh metal. The dimension of the small-mesh cell must be compare with Debay radius at the proper discharge conditions. It is stipulated by the fact that if the dimensions of the grid cell are compare with Debay radius then ionic sheaths on the negative electrode as if 'overlap' each other. Then if to supply the controlling impulse to the grid of the tacitron one can ensure interrupting the current through the tacitron. Thus a tacitron is full controlling discharge current commutator. There has been performed experimental investigation of the process of the current interruption.(distinguishing of the gas discharge), taking place in the discharge space between the anode and the cathode of the tacitron. The outcomes of experiments show that the process of the distinguishing may be divided on 4 stages, which differ one from another by elementary processes, going on there : - delay of the distinguishing of the discharge; - so-called 'slow ' stage; - decay of plasma inside the anode - grid gap; - decay of plasma inside the cathode - grid gap. The whole duration of the process of the discharge distinguishing equals mostly the second and the third stages together. The duration

  16. Method and device for controlling plume during laser welding

    SciTech Connect

    Fuerschbach, P.W.; Jellison, J.L.; Keicher, D.M.; Oberkampf, W.L.

    1991-02-12

    This patent describes a method and apparatus for enhancing the weldment of a laser welding system. The laser weld plume control device includes a cylindrical body defining an upside-down cone cavity; the upper surface of the body circumscribes the base of the cone cavity, and the vertex of the cone cavity forms an orifice concentrically located with respect to the laser beam and the plume which forms as a result of the welding operation. According to the method of the invention, gas is directed radially inward through inlets in the upper surface of the body into and through channels in the wall of the body and finally through the orifice of the body, and downward onto the surface of the weldment.

  17. Temperature-dependent liquid metal flowrate control device

    DOEpatents

    Carlson, Roger D.

    1978-01-01

    A temperature-dependent liquid metal flowrate control device includes a magnet and a ferromagnetic member defining therebetween a flow path for liquid metal, the ferromagnetic member being formed of a material having a curie temperature at which a change in the flow rate of the liquid metal is desired. According to the preferred embodiment the magnet is a cylindrical rod magnet axially disposed within a cylindrical member formed of a curie material and having iron pole pieces at the ends. A cylindrical iron shunt and a thin wall stainless steel barrier are disposed in the annulus between magnet and curie material. Below the curie temperature flow between steel barrier and curie material is impeded and above the curie temperature flow impedance is reduced.

  18. MEMS Device Being Developed for Active Cooling and Temperature Control

    NASA Technical Reports Server (NTRS)

    Moran, Matthew E.

    2001-01-01

    High-capacity cooling options remain limited for many small-scale applications such as microelectronic components, miniature sensors, and microsystems. A microelectromechanical system (MEMS) is currently under development at the NASA Glenn Research Center to meet this need. It uses a thermodynamic cycle to provide cooling or heating directly to a thermally loaded surface. The device can be used strictly in the cooling mode, or it can be switched between cooling and heating modes in milliseconds for precise temperature control. Fabrication and assembly are accomplished by wet etching and wafer bonding techniques routinely used in the semiconductor processing industry. Benefits of the MEMS cooler include scalability to fractions of a millimeter, modularity for increased capacity and staging to low temperatures, simple interfaces and limited failure modes, and minimal induced vibration.

  19. ATOM - an OMERO add-on for automated import of image data

    PubMed Central

    2011-01-01

    Background Modern microscope platforms are able to generate multiple gigabytes of image data in a single experimental session. In a routine research laboratory workflow, these data are initially stored on the local acquisition computer from which files need to be transferred to the experimenter's (remote) image repository (e.g., DVDs, portable hard discs or server-based storage) because of limited local data storage. Although manual solutions for this migration, such as OMERO - a client-server software for visualising and managing large amounts of image data - exist, this import process may be a time-consuming and tedious task. Findings We have developed ATOM, a Java-based and thus platform-independent add-on for OMERO enabling automated transfer of image data from a wide variety of acquisition software packages into OMERO. ATOM provides a graphical user interface and allows pre-organisation of experimental data for the transfer. Conclusions ATOM is a convenient extension of the OMERO software system. An automated interface to OMERO will be a useful tool for scientists working with file formats supported by the Bio-Formats file format library, a platform-independent library for reading the most common file formats of microscope images. PMID:21978452

  20. NIRS monitoring of muscle contraction to control a prosthetic device

    NASA Astrophysics Data System (ADS)

    Bianchi, Thomas; Zambarbieri, Daniela; Beltrami, Giorgio; Verni, Gennaro

    1999-01-01

    The fitting of upper-extremity amputees requires special efforts, and its significance has been increased by the development of the myoelectrically controlled prosthetic arm. This solution is not free of problems due to the nature of the amputation, to the electromagnetic noise affecting the myelectrical signal and to the perspiration due to the contact between socket and the residual limb. Starting from the fact that NIRS and electromyographic signals are similar during a muscle contraction, we have first studied the NIRS signal during forearm muscle contractions in normal and amputee subjects. Then a new system to interface the NIRS unit and the myoelectrical prosthetic hand has been developed. The NIRS unit has been used as optical sensor and all the operations (I/O and signal processing) are performed via software. This system has been tested on normal and amputee subjects performing hand grasping using a visual biofeedback control scheme. All the subjects have been able to perform these operations demonstrating the NIRS technique. This could represent an alternative solution for controlling a prosthetic device.

  1. Dipeptidyl peptidase-4 inhibitors or sodium glucose co-transporter-2 inhibitors as an add-on to insulin therapy: A comparative review

    PubMed Central

    Singh, Awadhesh Kumar; Singh, Ritu

    2016-01-01

    The gradual decline in β-cell function is inevitable in type 2 diabetes mellitus and therefore, substantial proportions of patients require insulin subsequently, in order to achieve optimal glucose control. While weight gain, hypoglycemia, and fluid retention especially during dose intensification is a known limitation to insulin therapy, these adverse effects also reduce patient satisfaction and treatment adherence. It is also possible that the benefits of intensive control achieved by insulin therapy, perhaps get nullified by the weight gain and hypoglycemia. In addition, improvement in plasma glucose or glycated hemoglobin (HbA1c) itself is associated with weight gain. Notably, studies have already suggested that reduction in body weight by ~3–5%, may allow a significantly better glycemic control. Thus, a class of drugs, which can reduce HbA1c effectively, yet are weight neutral or preferably reduce body weight, could be the most sought out strategy as an add-on therapy to insulin. While sulfonylureas (SUs) are associated with weight gain and hypoglycemia, pioglitazone increases body weight and fluid retention. Moreover, SUs are not recommended once premix or prandial insulin is commenced. The addition of newer agents, such as glucagon-like peptide-1 receptor agonist to insulin certainly appears to be an effective tool in reducing both HbA1c and body weight as is evident across the studies; however, this approach incurs an additional injection as well as cost. Dipeptidyl peptidase-4 inhibitors (DPP-4I) and sodium-glucose co-transporter-2 inhibitors (SGLT-2I) are other exciting options, as an add-on to insulin therapy primarily because these are oral drugs and do not possess any intrinsic potential of hypoglycemia. Furthermore, these are either weight neutral or induce significant weight loss. This review article aims to comparatively analyze the safety and efficacy of DPP-4I and SGLT-2I, as an add-on therapy to insulin. PMID:26904466

  2. Dipeptidyl peptidase-4 inhibitors or sodium glucose co-transporter-2 inhibitors as an add-on to insulin therapy: A comparative review.

    PubMed

    Singh, Awadhesh Kumar; Singh, Ritu

    2016-01-01

    The gradual decline in β-cell function is inevitable in type 2 diabetes mellitus and therefore, substantial proportions of patients require insulin subsequently, in order to achieve optimal glucose control. While weight gain, hypoglycemia, and fluid retention especially during dose intensification is a known limitation to insulin therapy, these adverse effects also reduce patient satisfaction and treatment adherence. It is also possible that the benefits of intensive control achieved by insulin therapy, perhaps get nullified by the weight gain and hypoglycemia. In addition, improvement in plasma glucose or glycated hemoglobin (HbA1c) itself is associated with weight gain. Notably, studies have already suggested that reduction in body weight by ~3-5%, may allow a significantly better glycemic control. Thus, a class of drugs, which can reduce HbA1c effectively, yet are weight neutral or preferably reduce body weight, could be the most sought out strategy as an add-on therapy to insulin. While sulfonylureas (SUs) are associated with weight gain and hypoglycemia, pioglitazone increases body weight and fluid retention. Moreover, SUs are not recommended once premix or prandial insulin is commenced. The addition of newer agents, such as glucagon-like peptide-1 receptor agonist to insulin certainly appears to be an effective tool in reducing both HbA1c and body weight as is evident across the studies; however, this approach incurs an additional injection as well as cost. Dipeptidyl peptidase-4 inhibitors (DPP-4I) and sodium-glucose co-transporter-2 inhibitors (SGLT-2I) are other exciting options, as an add-on to insulin therapy primarily because these are oral drugs and do not possess any intrinsic potential of hypoglycemia. Furthermore, these are either weight neutral or induce significant weight loss. This review article aims to comparatively analyze the safety and efficacy of DPP-4I and SGLT-2I, as an add-on therapy to insulin. PMID:26904466

  3. Vibration control for an overhung roller in textile machine considering the stiffness of control device stand

    NASA Astrophysics Data System (ADS)

    Mizutani, Kazuki; Kato, Kazumichi; Fujii, Takayoshi; Yili

    2004-01-01

    This paper treats a vibration control method that can be used in textile machinery to reduce the unbalanced vibration of an overhung roller-motor system. To control the vibration of the overhung roller, a drive motor with a hybrid type vibration control device consisted with rubber springs and electromagnets is used. When the vibration control system is set up in the textile machinery for industrial use, the stand supporting the control system to the base may be assumed not too rigid but elastic. For a certain value of the elastic stand stiffness, the vibration control performance of the overhung roller becomes very low. In order to prevent this deterioration, a stiffness control achieved by a positive feedback of the displacement signal of the rubber spring is proposed and the effectiveness of the stiffness control is confirmed by simulations and experiments.

  4. 40 CFR 65.162 - Nonflare control and recovery device monitoring records.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... control and halogen reduction device monitoring records. (1) Each owner or operator using a combustion control or halogen reduction device to comply with this subpart shall keep, as applicable, up-to-date and... process heater monitoring); § 65.154(c) (halogen reduction device monitoring); § 65.155(c) (other...

  5. 40 CFR 65.162 - Nonflare control and recovery device monitoring records.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... control and halogen reduction device monitoring records. (1) Each owner or operator using a combustion control or halogen reduction device to comply with this subpart shall keep, as applicable, up-to-date and... process heater monitoring); § 65.154(c) (halogen reduction device monitoring); § 65.155(c) (other...

  6. 40 CFR 65.162 - Nonflare control and recovery device monitoring records.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... control and halogen reduction device monitoring records. (1) Each owner or operator using a combustion control or halogen reduction device to comply with this subpart shall keep, as applicable, up-to-date and... process heater monitoring); § 65.154(c) (halogen reduction device monitoring); § 65.155(c) (other...

  7. 40 CFR 65.162 - Nonflare control and recovery device monitoring records.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... control and halogen reduction device monitoring records. (1) Each owner or operator using a combustion control or halogen reduction device to comply with this subpart shall keep, as applicable, up-to-date and... process heater monitoring); § 65.154(c) (halogen reduction device monitoring); § 65.155(c) (other...

  8. 40 CFR 65.162 - Nonflare control and recovery device monitoring records.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... control and halogen reduction device monitoring records. (1) Each owner or operator using a combustion control or halogen reduction device to comply with this subpart shall keep, as applicable, up-to-date and... process heater monitoring); § 65.154(c) (halogen reduction device monitoring); § 65.155(c) (other...

  9. 40 CFR 63.996 - General monitoring requirements for control and recovery devices.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... control and recovery devices. 63.996 Section 63.996 Protection of Environment ENVIRONMENTAL PROTECTION..., Recovery Devices and Routing to a Fuel Gas System or a Process § 63.996 General monitoring requirements for control and recovery devices. (a) General monitoring requirements applicability. (1) This section...

  10. 40 CFR 63.996 - General monitoring requirements for control and recovery devices.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... control and recovery devices. 63.996 Section 63.996 Protection of Environment ENVIRONMENTAL PROTECTION..., Recovery Devices and Routing to a Fuel Gas System or a Process § 63.996 General monitoring requirements for control and recovery devices. (a) General monitoring requirements applicability. (1) This section...

  11. 40 CFR 63.996 - General monitoring requirements for control and recovery devices.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... control and recovery devices. 63.996 Section 63.996 Protection of Environment ENVIRONMENTAL PROTECTION..., Recovery Devices and Routing to a Fuel Gas System or a Process § 63.996 General monitoring requirements for control and recovery devices. (a) General monitoring requirements applicability. (1) This section...

  12. Semi-active control of helicopter vibration using controllable stiffness and damping devices

    NASA Astrophysics Data System (ADS)

    Anusonti-Inthra, Phuriwat

    Semi-active concepts for helicopter vibration reduction are developed and evaluated in this dissertation. Semi-active devices, controllable stiffness devices or controllable orifice dampers, are introduced; (i) in the blade root region (rotor-based concept) and (ii) between the rotor and the fuselage as semi-active isolators (in the non-rotating frame). Corresponding semi-active controllers for helicopter vibration reduction are also developed. The effectiveness of the rotor-based semi-active vibration reduction concept (using stiffness and damping variation) is demonstrated for a 4-bladed hingeless rotor helicopter in moderate- to high-speed forward flight. A sensitivity study shows that the stiffness variation of root element can reduce hub vibrations when proper amplitude and phase are used. Furthermore, the optimal semi-active control scheme can determine the combination of stiffness variations that produce significant vibration reduction in all components of vibratory hub loads simultaneously. It is demonstrated that desired cyclic variations in properties of the blade root region can be practically achieved using discrete controllable stiffness devices and controllable dampers, especially in the flap and lag directions. These discrete controllable devices can produce 35--50% reduction in a composite vibration index representing all components of vibratory hub loads. No detrimental increases are observed in the lower harmonics of blade loads and blade response (which contribute to the dynamic stresses) and controllable device internal loads, when the optimal stiffness and damping variations are introduced. The effectiveness of optimal stiffness and damping variations in reducing hub vibration is retained over a range of cruise speeds and for variations in fundamental rotor properties. The effectiveness of the semi-active isolator is demonstrated for a simplified single degree of freedom system representing the semi-active isolation system. The rotor

  13. Failsafe device for air/fuel ratio feedback control system

    SciTech Connect

    Otsuka, K.; Hasegawa, S.; Narasaka, S.

    1983-11-15

    A fail safe device is disclosed, comprising means for detecting a failure in an air/fuel ratio feedback control system and generating a fault signal when such failure is detected, and means responsive to the fault signal to drive an actuator for driving an air/fuel ratio control valve and also responsive to a reference position signal supplied thereto during the above driving, which is generated when the actuator passes its reference position, to stop the actuator at the reference position. The actuator driving/stopping means may comprise means for repeatedly driving the actuator over a predetermined operating range inclusive of the reference position a plurality of times when it is not supplied with the reference position signal upon the actuator passing the reference position, and means for driving the actuator from its extreme operating position to a predetermined position and holding the same there when it is not supplied with the reference position signal even after a predetermined number of times of the above repeated driving of the actuator.

  14. Device for passive flow control around vertical axis marine turbine

    NASA Astrophysics Data System (ADS)

    Coşoiu, C. I.; Georgescu, A. M.; Degeratu, M.; Haşegan, L.; Hlevca, D.

    2012-11-01

    The power supplied by a turbine with the rotor placed in a free stream flow may be increased by augmenting the velocity in the rotor area. The energy of the free flow is dispersed and it may be concentrated by placing a profiled structure around the bare turbine in order to concentrate more energy in the rotor zone. At the Aerodynamic and Wind Engineering Laboratory (LAIV) of the Technical University of Civil Engineering of Bucharest (UTCB) it was developed a concentrating housing to be used for hydro or aeolian horizontal axis wind turbines, in order to increase the available energy in the active section of turbine rotor. The shape of the concentrating housing results by superposing several aero/hydro dynamic effects, the most important being the one generated by the passive flow control devices that were included in the housing structure. Those concentrating housings may be also adapted for hydro or aeolian turbines with vertical axis. The present paper details the numerical research effectuated at the LAIV to determine the performances of a vertical axis marine turbine equipped with such a concentrating device, in order to increase the energy quantity extracted from the main flow. The turbine is a Darrieus type one with three vertical straight blades, symmetric with respect to the axis of rotation, generated using a NACA4518 airfoil. The global performances of the turbine equipped with the concentrating housing were compared to the same characteristics of the bare turbine. In order to validate the numerical approach used in this paper, test cases from the literature resulting from experimental and numerical simulations for similar situations, were used.

  15. A cost-effective add-on-value card-assisted firewall over Taiwan's NHI VPN framework.

    PubMed

    Huang, Jyh-Win; Hou, Ting-Wei

    2007-06-01

    Besides the overall budget for building the infrastructure of a healthcare-service-based virtual private network (VPN) in Taiwan, two issues were considered critical for its acceptance by the country's 17,000 plus medical institutions. One was who was to pay for the network (ADSL or modem) connection fee; the other was who was to pay for the firewall/anti-virus software. This paper addresses the second issue by proposing an efficient freeware firewall, named card-assisted firewall (CAF), for NHI VPN edge-hosts, which is also an add-on-value application of the National Healthcare IC card that every insurant and medical professional has. The innovative concept is that any NHI VPN site (edge-host) can establish diversified secure-authenticated connections with other sites only by an authentication mechanism, which requires a NHI Java card state machine and the Access Control List of the host. It is different from two-factor authentication cards in four ways: (1) a PIN code is not a must; (2) it requires authentication with the remote IC card Data Centre; (3) the NHI cards are already available, no modification is needed, and there is no further cost for the deployment of the cards; (4) although the cards are in the reader, the communication cannot start unless the cards are in the corresponding states; i.e. the states allow communication. An implementation, on a Microsoft Windows XP platform, demonstrated the system's feasibility over an emulation of the NHI VPN framework. It maintained a high line speed, the driver took up 39 KB of disk space, installation was simple, not requiring any extra hardware or software, and the average packet processing time of the CAF driver measured was 0.3084 ms. The average overhead in comparing the Access Control List predefined routing in card, in an FTP testing experiment, was 5.7 micros (receiving) and 8 micros (sending). PMID:17541860

  16. Effects of gliclazide add on metformin on serum omentin-1 levels in patients with type 2 diabetes mellitus

    PubMed Central

    Al-Gareeb, Ali I.; Alrubai, Haidar F.; Suliaman, Sammar M.

    2016-01-01

    Background: Omentin is a newly identified adipokine that has beneficial influence against cardiovascular disorders. Hence, considering the impact of anti-diabetic drug on omentin levels may provide an adjuvant strategy to protect diabetic patients against valuable clinical hazards. Aim of the Study: To investigate the influence of metformin alone or in combination with gliclazide on the level of serum omentin among patients with type 2 diabetes mellitus (T2DM). Patients and Methods: A total of 70 newly diagnosed patients with T2DM were enrolled in this randomized, double-blind prospective study, and divided into two equal groups based on treatment regimen in which Group 1 treated with metformin (1000 mg) and Group 2 treated with metformin (1000 mg) plus gliclazide (80 mg). Blood glucose levels, HbA1C, insulin levels, and serum omentin-1 were measured at baseline and after 12 weeks of treatment. Result: Use of gliclazide as an add-on therapy to metformin in patients with T2DM result in better glycemic control evidenced by significant reductions in the levels of blood glucose levels and HbA1C and much more improvement in insulin sensitivity evidenced by significant decreased in insulin resistance index, whereas it has adverse impact on serum omentin-1 levels evidenced by significant decrement in omentin-1 level in comparison to their pretreatment levels among Group 2 patients. Conclusions: Adding of gliclazide to metformin in treatment of patients with T2DM might extend the therapeutic action of metformin in regarding much better controlling of glycemic indices, but, at the same time, it might attenuate the cardioprotective effects of metformin by its adverse influence on serum omentin-1 levels. PMID:27042415

  17. Mozart K.448 acts as a potential add-on therapy in children with refractory epilepsy.

    PubMed

    Lin, Lung-Chang; Lee, Wei-Te; Wang, Chien-Hua; Chen, Hsiu-Lin; Wu, Hui-Chuan; Tsai, Chin-Lin; Wei, Ruey-Chang; Mok, Hin-Kiu; Weng, Chia-Fen; Lee, Mei-Wen; Yang, Rei-Cheng

    2011-03-01

    Mozart's Sonata for two pianos in D major, K.448 (Mozart K.448), has been shown to improve mental function, leading to what is known as the Mozart effect. Our previous work revealed that epileptiform discharges in children with epilepsy decreased during and immediately after listening to Mozart K.448. In this study, we evaluated the long-term effects of Mozart K.448 on children with refractory epilepsy. Eleven children with refractory epilepsy were enrolled. All of the patients were diagnosed as having had refractory epilepsy for more than 1 year (range =1 year to 6 years 4 months, mean =3 years 11 months) and had been receiving at least two antiepileptic drugs (AED). During the study period, they listened to Mozart K.448 once a day before bedtime for 6 months. Seizure frequencies were recorded 6 months before they started listening to this music and monthly during the study period. All of the patients remained on the same AEDs during the 6-month study period. Frequencies of seizures were compared before and after listening to Mozart K.448. Eight of eleven patients were seizure free (N=2) or had very good responses (N=6) after 6 months of listening to Mozart K.448. The remaining three (27.3%) showed minimal or no effect (effectiveness <50%; unmodified or worsened seizure frequency). The average seizure reduction was 53.6 ± 62.0%. There were no significant differences in seizure reduction with IQ, etiology, or gender. We conclude that Mozart K.448 should be further studied as a potential add-on therapy in the treatment of children with refractory epilepsy. PMID:21292560

  18. Establishing a Near Term Lunar Farside Gravity Model via Inexpensive Add-on Navigation Payload

    NASA Technical Reports Server (NTRS)

    Folta, David; Mesarch, Michael; Miller, Ronald; Bell, David; Jedrey, Tom; Butman, Stanley; Asmar, Sami

    2007-01-01

    The Space Communications and Navigation, Constellation Integration Project (SCIP) is tasked with defining, developing, deploying and operating an evolving multi-decade communications and navigation (C/N) infrastructure including services and subsystems that will support both robotic and human exploration activities at the Moon. This paper discusses an early far side gravitational mapping service and related telecom subsystem that uses an existing spacecraft (WIND) and the Lunar Reconnaissance Orbiter (LRO) to collect data that would address several needs of the SCIP. An important aspect of such an endeavor is to vastly improve the current lunar gravity model while demonstrating the navigation and stationkeeping of a relay spacecraft. We describe a gravity data acquisition activity and the trajectory design of the relay orbit in an Earth-Moon L2 co-linear libration orbit. Several phases of the transfer from an Earth-Sun to the Earth-Moon region are discussed along with transfers within the Earth-Moon system. We describe a proposed, but not integrated, add-on to LRO scheduled to be launched in October of 2008. LRO provided a real host spacecraft against which we designed the science payload and mission activities. From a strategic standpoint, LRO was a very exciting first flight opportunity for gravity science data collection. Gravity Science data collection requires the use of one or more low altitude lunar polar orbiters. Variations in the lunar gravity field will cause measurable variations in the orbit of a low altitude lunar orbiter. The primary means to capture these induced motions is to monitor the Doppler shift of a radio signal to or from the low altitude spacecraft, given that the signal is referenced to a stable frequency reference. For the lunar far side, a secondary orbiting radio signal platform is required. We provide an in-depth look at link margins, trajectory design, and hardware implications. Our approach posed minimum risk to a host mission while

  19. Aromatase inhibitors as add-on treatment for men with epilepsy.

    PubMed

    Harden, Cynthia; MacLusky, Neil J

    2005-01-01

    Manipulation of neurosteroids to treat epilepsy has been an area of active research. The effect of testosterone on brain excitability and seizure threshold has been mixed; the estradiol metabolite of testosterone increases brain excitability, while the reduced metabolite of testosterone, 3alpha-androstanediol, decreases brain excitability, likely through an action at the gamma-amino butyric acid A receptor. Therefore, the metabolites of testosterone produce opposite effects on brain excitability in seizure models. Aromatase is the enzyme for the conversion of testosterone to 17beta-estradiol. Aromatase inhibitors could decrease brain excitability by decreasing local estradiol levels and therefore, could be beneficial for the treatment of epilepsy. Aromatase inhibitors are US Food and Drug Administration-approved and have a long history of safe use in menopausal women with breast cancer. This review presents the results of using anastrazole in an open-label, add-on manner in a small group of men with epilepsy in order to improve seizures. The results suggested some effect on reduction of seizures and no side effects. Testosterone levels did increase, but not to above the normal range. Letrozole used in a single case was also beneficial for seizures. It was concluded that aromatase inhibitors may be a useful adjunct to the treatment of epilepsy, but habituation to the treatment may be limiting. Many men with epilepsy have low testosterone, and aromatase inhibition may be helpful in restoring levels to normal. Modulation of reproductive hormones by aromatase inhibition as well as enhancement of the 3alpha-androstanediol pathway may be an avenue of epilepsy treatment that would not produce sedative side effects, which is often a limiting factor with standard antiseizure medications. A further interesting result is that elevated follicle stimulating hormone and luteal stimulating hormone levels were associated with seizure reduction, suggesting that they may be a

  20. A generic approach for examining the effectiveness of traffic control devices in school zones.

    PubMed

    Zhao, Xiaohua; Li, Jiahui; Ding, Han; Zhang, Guohui; Rong, Jian

    2015-09-01

    The effectiveness and performance of traffic control devices in school zones have been impacted significantly by many factors, such as driver behavioral attributes, roadway geometric features, environmental characteristics, weather and visibility conditions, region-wide traffic regulations and policies, control modes, etc. When deploying traffic control devices in school zones, efforts are needed to clarify: (1) whether traffic control device installation is warranted; and (2) whether other device effectively complements this traffic control device and strengthens its effectiveness. In this study, a generic approach is developed to examine and evaluate the effectiveness of various traffic control devices deployed in school zones through driving simulator-based experiments. A Traffic Control Device Selection Model (TCDSM) is developed and two representative school zones are selected as the testbed in Beijing for driving simulation implementation to enhance its applicability. Statistical analyses are conducted to extract the knowledge from test data recorded by a driving simulator. Multiple measures of effectiveness (MOEs) are developed and adopted including average speed, relative speed difference, and standard deviation of acceleration for traffic control device performance quantification. The experimental tests and analysis results reveal that the appropriateness of the installation of certain traffic control devices can be statistically verified by TCDSM. The proposed approach provides a generic framework to assess traffic control device performance in school zones including experiment design, statistical formulation, data analysis, simulation model implementation, data interpretation, and recommendation development. PMID:26072182

  1. A Wirelessly Powered and Controlled Device for Optical Neural Control of Freely-Behaving Animals

    PubMed Central

    Wentz, Christian T.; Bernstein, Jacob G.; Monahan, Patrick; Guerra, Alexander; Rodriguez, Alex; Boyden, Edward S.

    2011-01-01

    Optogenetics, the ability to use light to activate and silence specific neuron types within neural networks in vivo and in vitro, is revolutionizing neuroscientists’ capacity to understand how defined neural circuit elements contribute to normal and pathological brain functions. Typically awake behaving experiments are conducted by inserting an optical fiber into the brain, tethered to a remote laser, or by utilizing an implanted LED, tethered to a remote power source. A fully wireless system would enable chronic or longitudinal experiments where long duration tethering is impractical, and would also support high-throughput experimentation. However, the high power requirements of light sources (LEDs, lasers), especially in the context of the high-frequency pulse trains often desired in experiments, precludes battery-powered approaches from being widely applicable. We have developed a headborne device weighing 2 grams capable of wirelessly receiving power using a resonant RF power link and storing the energy in an adaptive supercapacitor circuit, which can algorithmically control one or more headborne LEDs via a microcontroller. The device can deliver approximately 2W of power to the LEDs in steady state, and 4.3W in bursts. We also present an optional radio transceiver module (1 gram) which, when added to the base headborne device, enables real-time updating of light delivery protocols; dozens of devices can be simultaneously controlled from one computer. We demonstrate use of the technology to wirelessly drive cortical control of movement in mice. These devices may serve as prototypes for clinical ultra-precise neural prosthetics that use light as the modality of biological control. PMID:21701058

  2. A wirelessly powered and controlled device for optical neural control of freely-behaving animals

    NASA Astrophysics Data System (ADS)

    Wentz, Christian T.; Bernstein, Jacob G.; Monahan, Patrick; Guerra, Alexander; Rodriguez, Alex; Boyden, Edward S.

    2011-08-01

    Optogenetics, the ability to use light to activate and silence specific neuron types within neural networks in vivo and in vitro, is revolutionizing neuroscientists' capacity to understand how defined neural circuit elements contribute to normal and pathological brain functions. Typically, awake behaving experiments are conducted by inserting an optical fiber into the brain, tethered to a remote laser, or by utilizing an implanted light-emitting diode (LED), tethered to a remote power source. A fully wireless system would enable chronic or longitudinal experiments where long duration tethering is impractical, and would also support high-throughput experimentation. However, the high power requirements of light sources (LEDs, lasers), especially in the context of the extended illumination periods often desired in experiments, precludes battery-powered approaches from being widely applicable. We have developed a headborne device weighing 2 g capable of wirelessly receiving power using a resonant RF power link and storing the energy in an adaptive supercapacitor circuit, which can algorithmically control one or more headborne LEDs via a microcontroller. The device can deliver approximately 2 W of power to the LEDs in steady state, and 4.3 W in bursts. We also present an optional radio transceiver module (1 g) which, when added to the base headborne device, enables real-time updating of light delivery protocols; dozens of devices can be controlled simultaneously from one computer. We demonstrate use of the technology to wirelessly drive cortical control of movement in mice. These devices may serve as prototypes for clinical ultra-precise neural prosthetics that use light as the modality of biological control.

  3. [About safety parameters for patient-controlled analgesia (PCA) devices].

    PubMed

    Sardin, B; Lecour, N; Terrier, G; Grouille, D

    2012-10-01

    During the course of preparation of an opioid prescription, the nurse in charge became aware that the patient-controlled analgesia (PCA) syringe driver did not permit programming for the delivery as required: a maximum bolus number (Bmax) was indicated but only a maximum cumulative dose (Dcmax) could be programmed. The prescription dose criteria were consistent with the guidelines of the French societies of palliative care, anesthesiology, and reanimation (Société française d'accompagnement et de soins palliatifs [Sfap] and Société française d'anesthésie réanimation [Sfar]). A Dcmax dose simulation was programmed and used in order to test this problem. This highlighted the following four defects: bolus delivery is not controlled, leading to potential overdose. When Dcmax is reached, the continuous flow stops, triggering an end dose failure and a new programming step is needed to restart infusion, increasing the risk of programming errors. Human intervention is required to stop the alarm, identify and solve the problem. Finally, Dcmax leads to random dose delivery in place of the predictability of dose delivery expected for opioid administration. On the other hand, Bmax is a limited dose, administered only as a bolus and regulated by the lockout interval. When the Bmax dose is reached, no alarm is triggered, the basal flow continues, but no additional doses can be delivered. Bmax and Dcmax systems are not interchangeable. No comparative study between Bmax and Dcmax could be found, and Sfap and Sfar guidelines are not precise and did not take into consideration the safety aspects of dose delivery however some facts tend to prefer that Bmax. Most of the syringe driver devices are configured for the Dcmax, but not all of them, and the physician is often forced to use the parameter of the available device restricting the choice between Bmax and Dcmax. This is not justified, whether by scientific evidence, industrial, manufacturing or commercial standards. It

  4. No effect of switching to high-dose rosuvastatin, add-on nicotinic acid, or add-on fenofibrate on serum vitamin D levels in patients with mixed dyslipidemia

    PubMed Central

    Makariou, E S; Elisaf, M; Kei, A; Challa, A; DiNicolantonio, J J; Liberopoulos, E

    2015-01-01

    Background Low 25-hydroxy-vitamin D [25(OH)VitD] levels may represent a novel cardiovascular disease risk factor. Several statins may increase 25(OH)VitD concentration. The effect of other lipid-lowering drugs is unknown. Aim To investigate whether switching to high-dose rosuvastatin, add-on-statin nicotinic acid or add-on-statin fenofibrate would alter 25(OH)VitD levels in patients with mixed dyslipidemia who are already on a conventional statin dose. Methods This is a prespecified analysis of a previously published study. Forty-four patients with mixed dyslipidemia not at treatment goal despite treatment with simvastatin 10-40 mg or atorvastatin 10-20 mg or rosuvastatin 5-10 mg were randomly allocated to switch to rosuvastatin 40 mg (n=17), add-on-statin extended release nicotinic acid (ER-NA)/laropiprant (LRPT) (1000/20 mg first four weeks and 2000/40 mg thereafter) (n=14), or add-on-statin micronized fenofibrate (200 mg) for three months. The endpoint for this analysis was between-group difference in changes in 25(OH)VitD levels. Results Serum 25(OH)VitD levels did not significantly change in any group. In the switch to the highest dose of rosuvastatin group and the add-on-statin ER-NA/LRPT group there was an insignificant decrease in 25(OH)VitD levels {-4.7% [from 16.8 (3.2-37) to 16.0 (7.9-51.6)] and -14.8% [from 12.8 (2.0-54.8) to 10.9 (2.4-34)], respectively]}, while in the add-on-statin fenofibrate group there was an insignificant increase [+13% (from 14.5 (1.0-42) to 16.4 (4.4-30.4) ng/mL)]. No significant difference between groups was found. Conclusion In patients already on a conventional statin dose, neither switching to high-dose rosuvastatin (40 mg) nor add-on-statin ER-NA/LRPT or fenofibrate were associated with significant changes in 25(OH)VitD serum levels. Hippokratia 2015; 19 (2):136-140. PMID:27418762

  5. Cooling device featuring thermoelectric and diamond materials for temperature control of heat-dissipating devices

    NASA Technical Reports Server (NTRS)

    Vandersande, Ian W. (Inventor); Ewell, Richard (Inventor); Fleurial, Jean-Pierre (Inventor); Lyon, Hylan B. (Inventor)

    1998-01-01

    A cooling device for lowering the temperature of a heat-dissipating device. The cooling device includes a heat-conducting substrate (composed, e.g., of diamond or another high thermal conductivity material) disposed in thermal contact with the heat-dissipating device. During operation, heat flows from the heat-dissipating device into the heat-conducting substrate, where it is spread out over a relatively large area. A thermoelectric cooling material (e.g., a Bi.sub.2 Te.sub.3 -based film or other thermoelectric material) is placed in thermal contact with the heat-conducting substrate. Application of electrical power to the thermoelectric material drives the thermoelectric material to pump heat into a second heat-conducting substrate which, in turn, is attached to a heat sink.

  6. Clinical Characteristics and Metabolic Predictors of Rapid Responders to Dipeptidyl Peptidase-4 Inhibitor as an Add-on Therapy to Sulfonylurea and Metformin

    PubMed Central

    Kim, Ye An; Yoo, Won Sang; Hong, Eun Shil; Ku, Eu Jeong; Park, Kyeong Seon; Lim, Soo; Cho, Young Min; Park, Kyong Soo; Jang, Hak Chul

    2015-01-01

    Background Dipeptidyl peptidase-4 (DPP-4) inhibitor add-on therapy is a new option for patients with inadequately controlled type 2 diabetes who are taking combined metformin and sulfonylurea (SU). We evaluated the efficacy and safety of this triple therapy and the characteristics of rapid responders and hypoglycemia-prone patients. Methods We included 807 patients with type 2 diabetes who were prescribed a newly added DPP-4 inhibitor to ongoing metformin and SU in 2009 to 2011. Glycemia and other metabolic parameters at baseline, 12, 24, and 52 weeks, as well as episodes of hypoglycemia were analyzed. Rapid responders were defined as patients with ≥25% reduction in glycosylated hemoglobin (HbA1c) within 12 weeks. Results At baseline, while on the submaximal metformin and SU combination, the mean HbA1c level was 8.4%. Twelve weeks after initiation of DPP-4 inhibitor add-on, 269 patients (34.4%) achieved an HbA1c level ≤7%. Sixty-six patients (8.2%, 47 men) were rapid responders. The duration of diabetes was shorter in rapid responders, and their baseline fasting plasma glucose (FPG), HbA1c, C-peptide, and homeostasis model assessment of insulin resistance were significantly higher. Patients who experienced hypoglycemia after taking DPP-4 inhibitor add-on were more likely to be female, to have a lower body weight and lower triglyceride and FPG levels, and to have higher homeostasis model assessment of β-cells. Conclusion An oral hypoglycemic triple agent combination including a DPP-4 inhibitor was effective in patients with uncontrolled diabetes. Proactive dose reduction of SU should be considered when a DPP-4 inhibitor is added for rapid responders and hypoglycemia-prone patients. PMID:26616595

  7. Device for controlling ignition timing in internal combustion engine

    SciTech Connect

    Tanaka, A.

    1988-01-12

    A device for controlling ignition timing in an internal combustion engine is described comprising: a. combustion state detection means disposed in the vicinity of the combustion chamber of each cylinder of an internal combustion engine for detecting the state of combustion in the combustion chamber, b. crankshaft angle detection means disposed in the vicinity of the rotating member of the internal combustion engine for detecting the angular position of a crankshaft of the internal combustion engine, c. maximum cylinder pressure angle calculation means which receives the outputs of the combustion state detection means and the crankshaft angle detection means and calculates the maximum cylinder pressure angle, d. cylinder pressure calculation means which receives the output of the combustion state detection means and calculates the cylinder pressure, e. ignition timing calculation means which receives the outputs of the crankshaft angle detection means, the maximum cylinder pressure angle calculation means and the cylinder pressure calculation means and calculates the ignition timing such that the maximum cylinder pressure angle converges on a target angle, and f. ignition means which receives the output of the ignition timing calculation means and ignites a fuel and air mixture in the combustion chamber, whereby the ignition timing calculation means detecting transient conditions in the engine driving operation on the basis of the output of the cylinder pressure calculation means.

  8. Loxapine Add-on for Adolescents and Adults with Autism Spectrum Disorders and Irritability

    PubMed Central

    Reed, Gregory; Cain, Sharon E.; Zhou, Xinghua; Barth, Francis X.; Aman, Michael G.; Palaguachi, Gladys I.; Mikhnev, Dmytro; Teng, Rujia; Andridge, Rebecca; Logan, Marilyn; Butler, Merlin G.; Han, Joan C.

    2015-01-01

    Abstract Objectives: Our clinical experience with low dose loxapine (5–15 mg/day) suggests promising efficacy and safety for irritability in autism spectrum disorders (ASD). We studied low dose loxapine prospectively in adolescents and adults with ASD and irritability. Additionally, we measured loxapine and metabolite concentrations, and brain-derived neurotrophic factor (BDNF) as a biomarker of neuromodulation. Methods: We performed a 12 week open trial of add-on loxapine in subjects, ages 13–65 years, diagnosed with ASD, and Aberrant Behavior Checklist-Irritability (ABC-I) subscale scores >14. Loxapine was dosed flexibly up to 15 mg daily, starting with 5 mg on alternate days. From weeks 1 to 6, other psychoactive medications were tapered if possible; from weeks 6 to 12, all medication doses were held stable. The primary outcome was the Clinical Global Impressions-Improvement subscale (CGI-I), ratings of Much Improved or Very Much Improved. Secondary outcomes were the ABC-I, Repetitive Behavior Scale-Revised, and Schalock Quality of Life scale. Serum BDNF and loxapine and metabolite concentrations were assayed. BDNF rs6265 was genotyped. Results: Sixteen subjects were enrolled; 12 completed all visits. Median age was 18 years (range 13–39). Median final loxapine dose was 7.5 mg/day (2.5–15). All 14 subjects (100%) with data at week 12 were rated as Much Improved on CGI-I at 12 weeks. Mean change on ABC-I at 12 weeks was −31%, p=0.01. Mean body mass index (BMI)-Z decreased between weeks 6 and 12, p=0.03. Side effects were minimal, and prolactin elevation occurred in only one subject. BDNF concentrations measured in 11 subjects increased significantly (p=0.04). Subjects with AG genotype for BDNF rs6265 required a lower dose of loxapine at study end, but had similar behavioral and BDNF concentration changes as the GG genotype. Conclusions: Low dose loxapine shows promise as a repurposed drug for irritability in ASD. Loxapine effects on BDNF warrant

  9. Inventory Control. Easily Made Electronic Device for Conductivity Experiments.

    ERIC Educational Resources Information Center

    Gadek, Frank J.

    1987-01-01

    Describes how to construct an electronic device to be used in conductivity experiments using a 35 millimeter film canister, nine volt battery replacement snaps, a 200-300 ohm resistor, and a light-emitting diode. Provides a diagram and photographs of the device. (TW)

  10. 40 CFR 65.146 - Nonflare control devices used for equipment leaks only.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... equipment leaks only. 65.146 Section 65.146 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Routing to a Fuel Gas System or a Process § 65.146 Nonflare control devices used for equipment leaks only... nonflare control device used only to control emissions from equipment leaks. (c) Monitoring...

  11. Breath alcohol ignition interlock devices: controlling the recidivist.

    PubMed

    Raub, Richard A; Lucke, Roy E; Wark, Richard I

    2003-09-01

    This study compares the recidivism rates of two groups of Illinois drivers who had their driver's licenses revoked for alcohol-impaired driving and who received restricted driving permits. Drivers in both groups had more than two driving under the influence (DUI) actions against their record within 5 years or were classed as level III alcohol dependents. Drivers in one group were required to install breath alcohol ignition interlock devices in their vehicles and drivers in the other group were not. The research found that drivers with the interlock were one-fifth as likely to be arrested for DUI during the 1 year the device was installed as the comparison group, which did not have the device. However, once the ignition interlock was removed, drivers in this group rapidly returned to DUI arrest rates similar to those in the comparison group. These findings echo previous literature. Additionally, the study showed that this voluntary program in Illinois reached only 16% of the drivers who met the requirements for installing the interlock device. Finally, this study found that individuals who were removed from the interlock program and returned to revoked status continued to drive. Within 3 years, approximately 50% of this latter group were involved in a crash or were arrested for DUI or with an invalid driver's license. Conclusions drawn from the study suggest that the breath alcohol ignition interlock device is effective in preventing continued driving while impaired. However, the large-scale effectiveness of the device is limited since most of the drivers eligible for the device do not have it installed. To have a significant impact, the interlock device must represent a better alternative to drivers whose licenses were suspended or revoked because of alcohol arrests compared to remaining on revoked status without having the device installed. Finally the research suggests that, given the rapid return to predevice recidivism, the devices should remain installed until

  12. Breath alcohol ignition interlock devices: controlling the recidivist.

    PubMed

    Raub, Richard A; Lucke, Roy E; Wark, Richard I

    2003-01-01

    This study compares the recidivism rates of two groups of Illinois drivers who had their driver's licenses revoked for alcohol-impaired driving and who received restricted driving permits. Drivers in both groups had more than two driving under the influence (DUI) actions against their record within 5 years or were classed as level III alcohol dependents. Drivers in one group were required to install breath alcohol ignition interlock devices in their vehicles and drivers in the other group were not. The research found that drivers with the interlock were one-fifth as likely to be arrested for DUI during the 1 year the device was installed as the comparison group, which did not have the device. However, once the ignition interlock was removed, drivers in this group rapidly returned to DUI arrest rates similar to those in the comparison group. These findings echo previous literature. Additionally, the study showed that this voluntary program in Illinois reached only 16% of the drivers who met the requirements for installing the interlock device. Finally, this study found that individuals who were removed from the interlock program and returned to revoked status continued to drive. Within 3 years, approximately 50% of this latter group were involved in a crash or were arrested for DUI or with an invalid driver's license. Conclusions drawn from the study suggest that the breath alcohol ignition interlock device is effective in preventing continued driving while impaired. However, the large-scale effectiveness of the device is limited since most of the drivers eligible for the device do not have it installed. To have a significant impact, the interlock device must represent a better alternative to drivers whose licenses were suspended or revoked because of alcohol arrests compared to remaining on revoked status without having the device installed. Finally the research suggests that, given the rapid return to predevice recidivism, the devices should remain installed until

  13. Controlled release of sugar and toxicant from a novel device for controlling pest insects.

    PubMed

    Hu, X P; Shasha, B S; McGuire, M R; Prokopy, R J

    1998-01-01

    A novel biodegradable device, designed for long-lasting residual effectiveness of feeding stimulant (sugar) and insecticide (dimethoate) against apple maggot files and other insects, was formulated. The device is an 8-cm diameter fruit-mimicking sphere, consisting of 42-50% sugar entrapped in a mixture of gelatinized corn flour and wheat flour in the presence of glycerin, and coated with a layer of latex paint containing dimethoate and sugar. We found that the outer layer of paint prevents cracking of the sphere upon drying and creates a barrier to control the release of both sugar and dimethoate. Releases of each ingredient were screened first by chemical analysis and then by bioassays in the laboratory and in field cages against apple maggot flies. Chemical analysis demonstrated strong potential for controlled release of water-soluble feeding stimulant and water-insoluble insecticide measured as a function of the amount of rainfall and duration of exposure time. Field results showed greater than 70% insecticidal activity after 11 weeks of sphere exposure in an orchard. This device has the potential to be used for a variety of insect-control applications through manipulating its shape, color and texture into forms known to be attractive to target insects, and by employing various toxicants designed to be effective against such insects. PMID:9685892

  14. 78 FR 36702 - Cardiovascular Devices; Reclassification of Intra-Aortic Balloon and Control Systems (IABP) for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-19

    ... the 90-day period. Since these devices were classified in 1980, the 30-month period has expired (45 FR.... II. Regulatory History of the Device In the preamble to the proposed rule (44 FR 13369; March 9, 1979... and control system devices into class III after receiving no comments on the proposed rule (45 FR...

  15. 40 CFR 60.2141 - By what date must I conduct the initial air pollution control device inspection?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... air pollution control device inspection? 60.2141 Section 60.2141 Protection of Environment... initial air pollution control device inspection? (a) The initial air pollution control device inspection... startup. (b) Within 10 operating days following an air pollution control device inspection, all...

  16. 40 CFR 60.2141 - By what date must I conduct the initial air pollution control device inspection?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... air pollution control device inspection? 60.2141 Section 60.2141 Protection of Environment... initial air pollution control device inspection? (a) The initial air pollution control device inspection... startup. (b) Within 10 operating days following an air pollution control device inspection, all...

  17. The Add-On Impact of Mobile Applications in Learning Strategies: A Review Study

    ERIC Educational Resources Information Center

    Jeng, Yu-Lin; Wu, Ting-Ting; Huang, Yueh-Min; Tan, Qing; Yang, Stephen J. H.

    2010-01-01

    Mobile devices are more powerful and portable nowadays with plenty of useful tools for assisting people to handle daily life. With the advance of mobile technology, the issue of mobile learning has been widely investigated in e-learning research. Many researches consider it is important to integrate pedagogical and technical strengths of mobile…

  18. Novel Rigid External Distraction Device Improves Stability and Controls the Vector During Midfacial Advancement.

    PubMed

    Resnick, Cory M; Rottgers, Stephen Alex; Langenfeld, Christopher C; Mulliken, John B; Padwa, Bonnie L

    2016-06-01

    The major limitation of the rigid external devices currently used for midfacial distraction after subcranial Le Fort III osteotomies is the ductile wire that connects the midface to the device, which makes it difficult to control the vector and force during distraction. The authors describe a novel external appliance that addresses this and other problems of contemporary devices, and application of a custom cranial template that facilitates precise placement of the device to achieve the planned vector of distraction. PMID:27213737

  19. Space station systems technology study (add-on task). Volume 1: Executive summary

    NASA Technical Reports Server (NTRS)

    1985-01-01

    System concepts were characterized in order to define cost versus benefits for autonomous functional control and for controls and displays for OMV, OTV, and spacecraft servicing and operation. The attitude control topic focused on characterizing the Space Station attitude control problem through simulation of control system responses to structural disturbances. The first two topics, mentioned above, focused on specific technology items that require advancement in order to support an early 1990s initial launch of a Space Station, while the attitude control study was an exploration of the capability of conventional controller techniques.

  20. Space station systems technology study (add-on task). Volume 3: Technology advancement program plan

    NASA Technical Reports Server (NTRS)

    1985-01-01

    Program plans are given for an integrating controller for space station autonomy as well as for controls and displays. The technical approach, facility requirements and candidate facilities, development schedules, and resource requirements estimates are given.